gene_id BaseMean BaseMean_control_T24_NC BaseMean_case_T24_circXRN2 FoldChange log2FoldChange p-value q-value Expression_T24_NC Expression_T24_circXRN2 gene_Dbxref description GO_id GO_term pathway pathway_description TF_family A4GALT 473.3732849 569.3902983 377.3562715 0.662737445 -0.59349066 0.152290059 1 7.955202736 5.499316193 53947 "alpha 1,4-galactosyltransferase (P blood group)" "GO:0001576,GO:0006688,GO:0007009,GO:0008378,GO:0015643,GO:0016020,GO:0016758,GO:0030173,GO:0050512" "globoside biosynthetic process|glycosphingolipid biosynthetic process|plasma membrane organization|galactosyltransferase activity|toxic substance binding|membrane|transferase activity, transferring hexosyl groups|integral component of Golgi membrane|lactosylceramide 4-alpha-galactosyltransferase activity" "hsa00601,hsa00603" Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series AAAS 1089.246931 1012.926056 1165.567805 1.150693871 0.202504072 0.560776472 1 28.20293093 33.85088079 8086 aladin WD repeat nucleoporin "GO:0000922,GO:0001578,GO:0003674,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005813,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006913,GO:0007612,GO:0009566,GO:0016020,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0046822,GO:0060964,GO:0072686,GO:0075733,GO:0090307,GO:1900034" spindle pole|microtubule bundle formation|molecular_function|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|centrosome|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nucleocytoplasmic transport|learning|fertilization|membrane|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|regulation of nucleocytoplasmic transport|regulation of gene silencing by miRNA|mitotic spindle|intracellular transport of virus|mitotic spindle assembly|regulation of cellular response to heat hsa03013 RNA transport AACS 1510.865626 1378.310205 1643.421047 1.19234483 0.253801528 0.443855238 1 20.85645339 25.93930059 65985 acetoacetyl-CoA synthetase "GO:0001889,GO:0005515,GO:0005524,GO:0005829,GO:0006631,GO:0007584,GO:0014074,GO:0030729,GO:0032024,GO:0034201,GO:0042493,GO:0042594,GO:0045471,GO:0046951,GO:0047760,GO:0050872,GO:0060612,GO:0071333,GO:0071394,GO:0071397" liver development|protein binding|ATP binding|cytosol|fatty acid metabolic process|response to nutrient|response to purine-containing compound|acetoacetate-CoA ligase activity|positive regulation of insulin secretion|response to oleic acid|response to drug|response to starvation|response to ethanol|ketone body biosynthetic process|butyrate-CoA ligase activity|white fat cell differentiation|adipose tissue development|cellular response to glucose stimulus|cellular response to testosterone stimulus|cellular response to cholesterol "hsa00280,hsa00650" "Valine, leucine and isoleucine degradation|Butanoate metabolism" AADAC 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.123049525 0 13 arylacetamide deacetylase "GO:0003824,GO:0004806,GO:0005515,GO:0005789,GO:0006805,GO:0010898,GO:0016021,GO:0016298,GO:0016787,GO:0017171,GO:0019213" catalytic activity|triglyceride lipase activity|protein binding|endoplasmic reticulum membrane|xenobiotic metabolic process|positive regulation of triglyceride catabolic process|integral component of membrane|lipase activity|hydrolase activity|serine hydrolase activity|deacetylase activity AADAT 128.298896 115.7049804 140.8928116 1.217690121 0.284147041 0.655548358 1 2.112490654 2.683165793 51166 aminoadipate aminotransferase "GO:0005759,GO:0006103,GO:0006536,GO:0006554,GO:0006569,GO:0008483,GO:0009058,GO:0016212,GO:0030170,GO:0033512,GO:0042803,GO:0047536,GO:0070189,GO:0097052,GO:1901605" mitochondrial matrix|2-oxoglutarate metabolic process|glutamate metabolic process|lysine catabolic process|tryptophan catabolic process|transaminase activity|biosynthetic process|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding|L-lysine catabolic process to acetyl-CoA via saccharopine|protein homodimerization activity|2-aminoadipate transaminase activity|kynurenine metabolic process|L-kynurenine metabolic process|alpha-amino acid metabolic process "hsa00310,hsa00380" Lysine degradation|Tryptophan metabolism AAGAB 857.4358878 893.1612522 821.7105234 0.920002431 -0.120290421 0.742082225 1 12.20600824 11.71328104 79719 alpha and gamma adaptin binding protein "GO:0005515,GO:0005737,GO:0005829,GO:0015031,GO:0016607" protein binding|cytoplasm|cytosol|protein transport|nuclear speck AAK1 736.5210317 844.4433657 628.5986978 0.744394146 -0.425861386 0.254523851 1 2.022131322 1.570103331 22848 AP2 associated kinase 1 "GO:0004674,GO:0005112,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005905,GO:0006468,GO:0006897,GO:0019897,GO:0030136,GO:0031252,GO:0032880,GO:0035612,GO:0043195,GO:0045747,GO:0046777,GO:0050821,GO:0061024,GO:0106310,GO:0106311,GO:2000369" protein serine/threonine kinase activity|Notch binding|protein binding|ATP binding|cytoplasm|cytosol|clathrin-coated pit|protein phosphorylation|endocytosis|extrinsic component of plasma membrane|clathrin-coated vesicle|cell leading edge|regulation of protein localization|AP-2 adaptor complex binding|terminal bouton|positive regulation of Notch signaling pathway|protein autophosphorylation|protein stabilization|membrane organization|protein serine kinase activity|protein threonine kinase activity|regulation of clathrin-dependent endocytosis AAMDC 224.9235945 187.7668541 262.0803348 1.395775287 0.481066694 0.354882021 1 5.357593668 7.800118618 28971 adipogenesis associated Mth938 domain containing "GO:0005515,GO:0005737,GO:0045600" protein binding|cytoplasm|positive regulation of fat cell differentiation AAMP 1845.374773 1783.277636 1907.47191 1.069643824 0.09713048 0.765673071 1 51.17094689 57.09243566 14 angio associated migratory cell protein "GO:0001525,GO:0005515,GO:0005829,GO:0005886,GO:0008201,GO:0009986,GO:0010595,GO:0014909,GO:0015630,GO:0030154,GO:0045171" angiogenesis|protein binding|cytosol|plasma membrane|heparin binding|cell surface|positive regulation of endothelial cell migration|smooth muscle cell migration|microtubule cytoskeleton|cell differentiation|intercellular bridge AAR2 1441.007608 1485.895538 1396.119678 0.939581312 -0.089910077 0.788819105 1 23.5541055 23.08431095 25980 AAR2 splicing factor "GO:0000244,GO:0005681,GO:0005682" spliceosomal tri-snRNP complex assembly|spliceosomal complex|U5 snRNP AARS1 3708.130975 3138.243854 4278.018097 1.363188552 0.446985125 0.160670885 1 46.24410246 65.75491412 16 alanyl-tRNA synthetase 1 "GO:0000049,GO:0002161,GO:0002196,GO:0004813,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006400,GO:0006418,GO:0006419,GO:0008033,GO:0008270,GO:0016020,GO:0016597,GO:0070062,GO:0106074" tRNA binding|aminoacyl-tRNA editing activity|Ser-tRNA(Ala) hydrolase activity|alanine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrion|cytosol|tRNA modification|tRNA aminoacylation for protein translation|alanyl-tRNA aminoacylation|tRNA processing|zinc ion binding|membrane|amino acid binding|extracellular exosome|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis AARS2 439.5679766 481.089129 398.0468243 0.827386861 -0.273366047 0.519229918 1 4.626940221 3.993175871 57505 "alanyl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0002161,GO:0004813,GO:0005515,GO:0005524,GO:0005739,GO:0006400,GO:0006419,GO:0008270,GO:0016597,GO:0070143,GO:0106074" tRNA binding|aminoacyl-tRNA editing activity|alanine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|tRNA modification|alanyl-tRNA aminoacylation|zinc ion binding|amino acid binding|mitochondrial alanyl-tRNA aminoacylation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis AASDH 355.6383926 333.9205136 377.3562715 1.130078136 0.176422527 0.698053159 1 3.573942522 4.212810904 132949 aminoadipate-semialdehyde dehydrogenase "GO:0005524,GO:0006631,GO:0016878,GO:0019482,GO:0043041" ATP binding|fatty acid metabolic process|acid-thiol ligase activity|beta-alanine metabolic process|amino acid activation for nonribosomal peptide biosynthetic process AASDHPPT 951.351728 1049.464471 853.2389847 0.813023221 -0.298631537 0.401239484 1 11.81410829 10.01889504 60496 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase "GO:0000287,GO:0005515,GO:0005829,GO:0008897,GO:0015939,GO:0019878,GO:0070062" magnesium ion binding|protein binding|cytosol|holo-[acyl-carrier-protein] synthase activity|pantothenate metabolic process|lysine biosynthetic process via aminoadipic acid|extracellular exosome hsa00770 Pantothenate and CoA biosynthesis AASS 989.3168212 1018.000836 960.6328061 0.943646382 -0.083681763 0.814913851 1 8.843593665 8.704703622 10157 aminoadipate-semialdehyde synthase "GO:0000122,GO:0003714,GO:0004753,GO:0004754,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006554,GO:0019878,GO:0031061,GO:0033512,GO:0042393,GO:0043231,GO:0047130,GO:0047131,GO:0055114" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|saccharopine dehydrogenase activity|saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|lysine catabolic process|lysine biosynthetic process via aminoadipic acid|negative regulation of histone methylation|L-lysine catabolic process to acetyl-CoA via saccharopine|histone binding|intracellular membrane-bounded organelle|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|oxidation-reduction process" hsa00310 Lysine degradation AATF 1576.002195 1688.886731 1463.117659 0.866320773 -0.207026784 0.530376584 1 41.48213138 37.4848451 26574 apoptosis antagonizing transcription factor "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0005794,GO:0006357,GO:0006974,GO:0007155,GO:0007346,GO:0019901,GO:0032929,GO:0040016,GO:0042254,GO:0042985,GO:0043066,GO:0043522,GO:0045944,GO:0048156,GO:2000378,GO:2001234" RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|Golgi apparatus|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|cell adhesion|regulation of mitotic cell cycle|protein kinase binding|negative regulation of superoxide anion generation|embryonic cleavage|ribosome biogenesis|negative regulation of amyloid precursor protein biosynthetic process|negative regulation of apoptotic process|leucine zipper domain binding|positive regulation of transcription by RNA polymerase II|tau protein binding|negative regulation of reactive oxygen species metabolic process|negative regulation of apoptotic signaling pathway AATK 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.027967323 0.056637284 9625 apoptosis associated tyrosine kinase "GO:0004672,GO:0004713,GO:0005515,GO:0005524,GO:0005575,GO:0006468,GO:0007420,GO:0008150,GO:0016021,GO:0038083,GO:0048471,GO:0106310,GO:0106311" protein kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|cellular_component|protein phosphorylation|brain development|biological_process|integral component of membrane|peptidyl-tyrosine autophosphorylation|perinuclear region of cytoplasm|protein serine kinase activity|protein threonine kinase activity ABCA1 568.999111 808.9199068 329.0783151 0.406811988 -1.297565903 0.001216392 0.103730371 3.069754202 1.3026066 19 ATP binding cassette subfamily A member 1 "GO:0005102,GO:0005319,GO:0005515,GO:0005524,GO:0005548,GO:0005768,GO:0005789,GO:0005886,GO:0005887,GO:0006869,GO:0007040,GO:0007186,GO:0007189,GO:0008203,GO:0008320,GO:0009306,GO:0010745,GO:0010875,GO:0010887,GO:0015485,GO:0016197,GO:0016887,GO:0019216,GO:0019905,GO:0023061,GO:0030139,GO:0031210,GO:0031267,GO:0032367,GO:0032489,GO:0033344,GO:0033700,GO:0034185,GO:0034186,GO:0034188,GO:0034380,GO:0034616,GO:0038027,GO:0042626,GO:0042632,GO:0043231,GO:0043691,GO:0045121,GO:0045332,GO:0045335,GO:0046623,GO:0048471,GO:0051117,GO:0055091,GO:0060155,GO:0071404,GO:0071806,GO:0090107,GO:0090108,GO:0090554,GO:0090556,GO:0097708,GO:0099039,GO:0120009,GO:0120020,GO:0140115,GO:0140328" signaling receptor binding|lipid transporter activity|protein binding|ATP binding|phospholipid transporter activity|endosome|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|lipid transport|lysosome organization|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|cholesterol metabolic process|protein transmembrane transporter activity|protein secretion|negative regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|cholesterol binding|endosomal transport|ATPase activity|regulation of lipid metabolic process|syntaxin binding|signal release|endocytic vesicle|phosphatidylcholine binding|small GTPase binding|intracellular cholesterol transport|regulation of Cdc42 protein signal transduction|cholesterol efflux|phospholipid efflux|apolipoprotein binding|apolipoprotein A-I binding|apolipoprotein A-I receptor activity|high-density lipoprotein particle assembly|response to laminar fluid shear stress|apolipoprotein A-I-mediated signaling pathway|ATPase-coupled transmembrane transporter activity|cholesterol homeostasis|intracellular membrane-bounded organelle|reverse cholesterol transport|membrane raft|phospholipid translocation|phagocytic vesicle|sphingolipid floppase activity|perinuclear region of cytoplasm|ATPase binding|phospholipid homeostasis|platelet dense granule organization|cellular response to low-density lipoprotein particle stimulus|protein transmembrane transport|regulation of high-density lipoprotein particle assembly|positive regulation of high-density lipoprotein particle assembly|phosphatidylcholine floppase activity|phosphatidylserine floppase activity|intracellular vesicle|sphingolipid translocation|intermembrane lipid transfer|cholesterol transfer activity|export across plasma membrane|floppase activity "hsa02010,hsa04975,hsa04979" ABC transporters|Fat digestion and absorption|Cholesterol metabolism ABCA10 18.5985361 25.37389921 11.823173 0.465958066 -1.10172797 0.340345687 1 0.203081302 0.098703534 10349 ATP binding cassette subfamily A member 10 "GO:0005319,GO:0005524,GO:0006869,GO:0016021,GO:0016887,GO:0042626,GO:0043231,GO:0055085" lipid transporter activity|ATP binding|lipid transport|integral component of membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport hsa02010 ABC transporters ABCA2 1899.515574 2015.702553 1783.328594 0.88471813 -0.176710207 0.585444568 1 12.43159076 11.47222252 20 ATP binding cassette subfamily A member 2 "GO:0000166,GO:0001573,GO:0005319,GO:0005524,GO:0005764,GO:0005765,GO:0005768,GO:0005815,GO:0005886,GO:0006357,GO:0006629,GO:0006684,GO:0006687,GO:0006869,GO:0007626,GO:0010008,GO:0010872,GO:0016020,GO:0016021,GO:0016887,GO:0031410,GO:0032289,GO:0032383,GO:0032384,GO:0032805,GO:0042493,GO:0042626,GO:0042632,GO:0042986,GO:0043190,GO:0043231,GO:0045540,GO:0046512,GO:0048545,GO:0052548,GO:0055085,GO:0060049,GO:0061135,GO:0070723,GO:0071072,GO:0090155,GO:0090156,GO:0090370,GO:0099038,GO:0099040,GO:0150104,GO:0150110,GO:1901873,GO:1902004,GO:1902993,GO:1904375,GO:1905598,GO:1905601,GO:2000008" nucleotide binding|ganglioside metabolic process|lipid transporter activity|ATP binding|lysosome|lysosomal membrane|endosome|microtubule organizing center|plasma membrane|regulation of transcription by RNA polymerase II|lipid metabolic process|sphingomyelin metabolic process|glycosphingolipid metabolic process|lipid transport|locomotory behavior|endosome membrane|regulation of cholesterol esterification|membrane|integral component of membrane|ATPase activity|cytoplasmic vesicle|central nervous system myelin formation|regulation of intracellular cholesterol transport|negative regulation of intracellular cholesterol transport|positive regulation of low-density lipoprotein particle receptor catabolic process|response to drug|ATPase-coupled transmembrane transporter activity|cholesterol homeostasis|positive regulation of amyloid precursor protein biosynthetic process|ATP-binding cassette (ABC) transporter complex|intracellular membrane-bounded organelle|regulation of cholesterol biosynthetic process|sphingosine biosynthetic process|response to steroid hormone|regulation of endopeptidase activity|transmembrane transport|regulation of protein glycosylation|endopeptidase regulator activity|response to cholesterol|negative regulation of phospholipid biosynthetic process|negative regulation of sphingolipid biosynthetic process|cellular sphingolipid homeostasis|negative regulation of cholesterol efflux|ceramide floppase activity|ceramide translocation|transport across blood-brain barrier|negative regulation of cholesterol esterification|regulation of post-translational protein modification|positive regulation of amyloid-beta formation|positive regulation of amyloid precursor protein catabolic process|regulation of protein localization to cell periphery|negative regulation of low-density lipoprotein receptor activity|negative regulation of receptor-mediated endocytosis involved in cholesterol transport|regulation of protein localization to cell surface "hsa02010,hsa04142" ABC transporters|Lysosome ABCA3 478.2941638 636.3773922 320.2109354 0.503177736 -0.990860006 0.01712198 0.570200991 4.881894867 2.562275175 21 ATP binding cassette subfamily A member 3 "GO:0005319,GO:0005524,GO:0005615,GO:0005886,GO:0006855,GO:0006869,GO:0008559,GO:0010875,GO:0015914,GO:0016021,GO:0016887,GO:0030324,GO:0030659,GO:0032464,GO:0042493,GO:0042626,GO:0042908,GO:0043129,GO:0043231,GO:0044267,GO:0046470,GO:0046471,GO:0046618,GO:0046890,GO:0051384,GO:0055085,GO:0055091,GO:0070925,GO:0097208,GO:0097232,GO:0097233,GO:0120009,GO:0120019,GO:0140345,GO:0150172,GO:1902995" lipid transporter activity|ATP binding|extracellular space|plasma membrane|drug transmembrane transport|lipid transport|ATPase-coupled xenobiotic transmembrane transporter activity|positive regulation of cholesterol efflux|phospholipid transport|integral component of membrane|ATPase activity|lung development|cytoplasmic vesicle membrane|positive regulation of protein homooligomerization|response to drug|ATPase-coupled transmembrane transporter activity|xenobiotic transport|surfactant homeostasis|intracellular membrane-bounded organelle|cellular protein metabolic process|phosphatidylcholine metabolic process|phosphatidylglycerol metabolic process|drug export|regulation of lipid biosynthetic process|response to glucocorticoid|transmembrane transport|phospholipid homeostasis|organelle assembly|alveolar lamellar body|lamellar body membrane|alveolar lamellar body membrane|intermembrane lipid transfer|phosphatidylcholine transfer activity|phosphatidylcholine flippase activity|regulation of phosphatidylcholine metabolic process|positive regulation of phospholipid efflux hsa02010 ABC transporters ABCA5 178.3340972 168.4826908 188.1855036 1.116942653 0.159555115 0.783214013 1 0.90249116 1.051452752 23461 ATP binding cassette subfamily A member 5 "GO:0000139,GO:0005319,GO:0005524,GO:0005764,GO:0005765,GO:0005770,GO:0005794,GO:0006869,GO:0010745,GO:0016021,GO:0016887,GO:0031902,GO:0033344,GO:0034375,GO:0042626,GO:0043231,GO:0043691,GO:0055085" Golgi membrane|lipid transporter activity|ATP binding|lysosome|lysosomal membrane|late endosome|Golgi apparatus|lipid transport|negative regulation of macrophage derived foam cell differentiation|integral component of membrane|ATPase activity|late endosome membrane|cholesterol efflux|high-density lipoprotein particle remodeling|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|reverse cholesterol transport|transmembrane transport hsa02010 ABC transporters ABCA6 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.02012421 0 23460 ATP binding cassette subfamily A member 6 "GO:0005319,GO:0005524,GO:0005654,GO:0005886,GO:0006869,GO:0016021,GO:0042626,GO:0043231,GO:0055085" lipid transporter activity|ATP binding|nucleoplasm|plasma membrane|lipid transport|integral component of membrane|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport hsa02010 ABC transporters ABCA7 566.6198275 511.5378081 621.7018468 1.215358546 0.28138199 0.478739107 1 3.766184821 4.774434918 10347 ATP binding cassette subfamily A member 7 "GO:0000139,GO:0001891,GO:0005319,GO:0005524,GO:0005548,GO:0005783,GO:0005794,GO:0005886,GO:0006869,GO:0006909,GO:0007613,GO:0008542,GO:0009986,GO:0010875,GO:0016021,GO:0016887,GO:0018149,GO:0019216,GO:0030054,GO:0031901,GO:0032587,GO:0033344,GO:0033700,GO:0034188,GO:0034205,GO:0034380,GO:0034504,GO:0038027,GO:0042626,GO:0042985,GO:0043231,GO:0043409,GO:0044857,GO:0045332,GO:0045806,GO:0050766,GO:0055085,GO:0070374,GO:0090554,GO:0090556,GO:0097386,GO:0140328,GO:0150094,GO:1900223,GO:1901076,GO:1902430,GO:1902991,GO:1902995,GO:1903898,GO:2000010" Golgi membrane|phagocytic cup|lipid transporter activity|ATP binding|phospholipid transporter activity|endoplasmic reticulum|Golgi apparatus|plasma membrane|lipid transport|phagocytosis|memory|visual learning|cell surface|positive regulation of cholesterol efflux|integral component of membrane|ATPase activity|peptide cross-linking|regulation of lipid metabolic process|cell junction|early endosome membrane|ruffle membrane|cholesterol efflux|phospholipid efflux|apolipoprotein A-I receptor activity|amyloid-beta formation|high-density lipoprotein particle assembly|protein localization to nucleus|apolipoprotein A-I-mediated signaling pathway|ATPase-coupled transmembrane transporter activity|negative regulation of amyloid precursor protein biosynthetic process|intracellular membrane-bounded organelle|negative regulation of MAPK cascade|plasma membrane raft organization|phospholipid translocation|negative regulation of endocytosis|positive regulation of phagocytosis|transmembrane transport|positive regulation of ERK1 and ERK2 cascade|phosphatidylcholine floppase activity|phosphatidylserine floppase activity|glial cell projection|floppase activity|amyloid-beta clearance by cellular catabolic process|positive regulation of amyloid-beta clearance|positive regulation of engulfment of apoptotic cell|negative regulation of amyloid-beta formation|regulation of amyloid precursor protein catabolic process|positive regulation of phospholipid efflux|negative regulation of PERK-mediated unfolded protein response|positive regulation of protein localization to cell surface hsa02010 ABC transporters ABCB1 18.4797699 17.25425146 19.70528833 1.142054083 0.191630972 0.914048054 1 0.154803714 0.184409792 5243 ATP binding cassette subfamily B member 1 "GO:0000086,GO:0005515,GO:0005524,GO:0005654,GO:0005886,GO:0008559,GO:0009986,GO:0015562,GO:0016020,GO:0016021,GO:0016324,GO:0016887,GO:0022857,GO:0031625,GO:0042493,GO:0042626,GO:0042910,GO:0042969,GO:0042971,GO:0045332,GO:0046865,GO:0046943,GO:0047484,GO:0055085,GO:0070062,GO:0070633,GO:0072089,GO:0090554,GO:0090555,GO:0098591,GO:0099038,GO:0099040,GO:0140115,GO:0140328,GO:0150104,GO:1901529,GO:1905039,GO:1990962,GO:2001225" G2/M transition of mitotic cell cycle|protein binding|ATP binding|nucleoplasm|plasma membrane|ATPase-coupled xenobiotic transmembrane transporter activity|cell surface|efflux transmembrane transporter activity|membrane|integral component of membrane|apical plasma membrane|ATPase activity|transmembrane transporter activity|ubiquitin protein ligase binding|response to drug|ATPase-coupled transmembrane transporter activity|xenobiotic transmembrane transporter activity|lactone transport|lactone transmembrane transporter activity|phospholipid translocation|terpenoid transport|carboxylic acid transmembrane transporter activity|regulation of response to osmotic stress|transmembrane transport|extracellular exosome|transepithelial transport|stem cell proliferation|phosphatidylcholine floppase activity|phosphatidylethanolamine flippase activity|external side of apical plasma membrane|ceramide floppase activity|ceramide translocation|export across plasma membrane|floppase activity|transport across blood-brain barrier|positive regulation of anion channel activity|carboxylic acid transmembrane transport|xenobiotic transport across blood-brain barrier|regulation of chloride transport "hsa02010,hsa04976,hsa05206,hsa05226" ABC transporters|Bile secretion|MicroRNAs in cancer|Gastric cancer ABCB10 576.5061225 648.5568638 504.4553813 0.777812108 -0.362506402 0.358751102 1 6.315538777 5.123904599 23456 ATP binding cassette subfamily B member 10 "GO:0005515,GO:0005524,GO:0005743,GO:0006839,GO:0016887,GO:0032592,GO:0042626,GO:0042802,GO:0055085" protein binding|ATP binding|mitochondrial inner membrane|mitochondrial transport|ATPase activity|integral component of mitochondrial membrane|ATPase-coupled transmembrane transporter activity|identical protein binding|transmembrane transport hsa02010 ABC transporters ABCB4 250.4459514 248.6642123 252.2276906 1.014330483 0.02052778 0.976177208 1 1.585343041 1.677330552 5244 ATP binding cassette subfamily B member 4 "GO:0005515,GO:0005524,GO:0005548,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005925,GO:0006629,GO:0015629,GO:0016020,GO:0016021,GO:0016324,GO:0016887,GO:0019216,GO:0030136,GO:0032376,GO:0032782,GO:0042626,GO:0045121,GO:0045332,GO:0046581,GO:0055085,GO:0055088,GO:0061092,GO:0070062,GO:0090554,GO:0099038,GO:0099040,GO:1901557,GO:1903413,GO:2001140" protein binding|ATP binding|phospholipid transporter activity|nucleoplasm|cytoplasm|cytosol|plasma membrane|integral component of plasma membrane|focal adhesion|lipid metabolic process|actin cytoskeleton|membrane|integral component of membrane|apical plasma membrane|ATPase activity|regulation of lipid metabolic process|clathrin-coated vesicle|positive regulation of cholesterol transport|bile acid secretion|ATPase-coupled transmembrane transporter activity|membrane raft|phospholipid translocation|intercellular canaliculus|transmembrane transport|lipid homeostasis|positive regulation of phospholipid translocation|extracellular exosome|phosphatidylcholine floppase activity|ceramide floppase activity|ceramide translocation|response to fenofibrate|cellular response to bile acid|positive regulation of phospholipid transport "hsa02010,hsa04976" ABC transporters|Bile secretion ABCB6 223.6899112 305.5017465 141.878076 0.464410032 -1.106528957 0.034390064 0.832362361 5.192142857 2.515151535 10058 ATP binding cassette subfamily B member 6 (Langereis blood group) "GO:0000139,GO:0005524,GO:0005654,GO:0005739,GO:0005740,GO:0005741,GO:0005768,GO:0005774,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006779,GO:0006879,GO:0007420,GO:0010008,GO:0015439,GO:0015562,GO:0015886,GO:0016021,GO:0016887,GO:0020037,GO:0031307,GO:0035351,GO:0042626,GO:0043190,GO:0043588,GO:0055085,GO:0070062" Golgi membrane|ATP binding|nucleoplasm|mitochondrion|mitochondrial envelope|mitochondrial outer membrane|endosome|vacuolar membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|porphyrin-containing compound biosynthetic process|cellular iron ion homeostasis|brain development|endosome membrane|ATPase-coupled heme transmembrane transporter activity|efflux transmembrane transporter activity|heme transport|integral component of membrane|ATPase activity|heme binding|integral component of mitochondrial outer membrane|heme transmembrane transport|ATPase-coupled transmembrane transporter activity|ATP-binding cassette (ABC) transporter complex|skin development|transmembrane transport|extracellular exosome hsa02010 ABC transporters ABCB7 911.2179138 764.2618442 1058.173983 1.38456995 0.469437942 0.190319337 1 8.423757618 12.16568854 22 ATP binding cassette subfamily B member 7 "GO:0005515,GO:0005524,GO:0005743,GO:0006879,GO:0015232,GO:0015886,GO:0016021,GO:0016887,GO:0042626,GO:0055085" protein binding|ATP binding|mitochondrial inner membrane|cellular iron ion homeostasis|heme transmembrane transporter activity|heme transport|integral component of membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|transmembrane transport hsa02010 ABC transporters ABCB8 617.8845064 682.0504107 553.7186021 0.8118441 -0.300725384 0.439429173 1 7.338739574 6.214555131 11194 ATP binding cassette subfamily B member 8 "GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005743,GO:0016021,GO:0016887,GO:0031966,GO:0042626,GO:0043190,GO:0055085,GO:0062157,GO:0071805" protein binding|ATP binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial inner membrane|integral component of membrane|ATPase activity|mitochondrial membrane|ATPase-coupled transmembrane transporter activity|ATP-binding cassette (ABC) transporter complex|transmembrane transport|mitochondrial ATP-gated potassium channel complex|potassium ion transmembrane transport hsa02010 ABC transporters ABCB9 326.8106247 350.1598091 303.4614403 0.866636982 -0.206500292 0.657344499 1 2.654049542 2.399176358 23457 ATP binding cassette subfamily B member 9 "GO:0002474,GO:0005515,GO:0005524,GO:0005764,GO:0005765,GO:0005769,GO:0005783,GO:0015031,GO:0015433,GO:0015440,GO:0015833,GO:0016021,GO:0016887,GO:0019885,GO:0022857,GO:0030176,GO:0042288,GO:0042626,GO:0042803,GO:0042824,GO:0043231,GO:0046978,GO:0055085" antigen processing and presentation of peptide antigen via MHC class I|protein binding|ATP binding|lysosome|lysosomal membrane|early endosome|endoplasmic reticulum|protein transport|ATPase-coupled peptide antigen transmembrane transporter activity|ATPase-coupled peptide transmembrane transporter activity|peptide transport|integral component of membrane|ATPase activity|antigen processing and presentation of endogenous peptide antigen via MHC class I|transmembrane transporter activity|integral component of endoplasmic reticulum membrane|MHC class I protein binding|ATPase-coupled transmembrane transporter activity|protein homodimerization activity|MHC class I peptide loading complex|intracellular membrane-bounded organelle|TAP1 binding|transmembrane transport "hsa02010,hsa04142" ABC transporters|Lysosome ABCC1 1816.614307 2073.555043 1559.673571 0.752173701 -0.41086223 0.205997446 1 14.48527557 11.36477485 4363 ATP binding cassette subfamily C member 1 "GO:0005524,GO:0005886,GO:0005887,GO:0006691,GO:0008559,GO:0009235,GO:0009925,GO:0015420,GO:0015431,GO:0015562,GO:0015889,GO:0016020,GO:0016323,GO:0016324,GO:0016328,GO:0016887,GO:0034040,GO:0034634,GO:0034775,GO:0042493,GO:0042626,GO:0042908,GO:0042910,GO:0042969,GO:0042971,GO:0045332,GO:0046943,GO:0050729,GO:0055085,GO:0060326,GO:0070062,GO:0070633,GO:0071716,GO:0099039,GO:0140115,GO:0140359,GO:0150104,GO:1904646,GO:1905039" ATP binding|plasma membrane|integral component of plasma membrane|leukotriene metabolic process|ATPase-coupled xenobiotic transmembrane transporter activity|cobalamin metabolic process|basal plasma membrane|ATPase-coupled vitamin B12 transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|efflux transmembrane transporter activity|cobalamin transport|membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|ATPase activity|ATPase-coupled lipid transmembrane transporter activity|glutathione transmembrane transporter activity|glutathione transmembrane transport|response to drug|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|lactone transport|lactone transmembrane transporter activity|phospholipid translocation|carboxylic acid transmembrane transporter activity|positive regulation of inflammatory response|transmembrane transport|cell chemotaxis|extracellular exosome|transepithelial transport|leukotriene transport|sphingolipid translocation|export across plasma membrane|ABC-type transporter activity|transport across blood-brain barrier|cellular response to amyloid-beta|carboxylic acid transmembrane transport "hsa01523,hsa02010,hsa04071,hsa04977,hsa05206" Antifolate resistance|ABC transporters|Sphingolipid signaling pathway|Vitamin digestion and absorption|MicroRNAs in cancer ABCC10 328.4248549 325.8008658 331.048844 1.016107932 0.023053654 0.967267821 1 2.564205827 2.717744678 89845 ATP binding cassette subfamily C member 10 "GO:0005524,GO:0005765,GO:0005886,GO:0006691,GO:0008559,GO:0015431,GO:0016020,GO:0016021,GO:0016323,GO:0016887,GO:0042626,GO:0042908,GO:0055085,GO:0071716,GO:0098656,GO:0140359" ATP binding|lysosomal membrane|plasma membrane|leukotriene metabolic process|ATPase-coupled xenobiotic transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|membrane|integral component of membrane|basolateral plasma membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|xenobiotic transport|transmembrane transport|leukotriene transport|anion transmembrane transport|ABC-type transporter activity hsa02010 ABC transporters ABCC11 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.016714916 0 85320 ATP binding cassette subfamily C member 11 "GO:0005524,GO:0005774,GO:0005886,GO:0005887,GO:0008514,GO:0008559,GO:0015216,GO:0015431,GO:0015432,GO:0015711,GO:0015721,GO:0015865,GO:0016020,GO:0016324,GO:0016887,GO:0030659,GO:0042626,GO:0042908,GO:0055085,GO:0070062,GO:0071716,GO:0098656" ATP binding|vacuolar membrane|plasma membrane|integral component of plasma membrane|organic anion transmembrane transporter activity|ATPase-coupled xenobiotic transmembrane transporter activity|purine nucleotide transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|ATPase-coupled bile acid transmembrane transporter activity|organic anion transport|bile acid and bile salt transport|purine nucleotide transport|membrane|apical plasma membrane|ATPase activity|cytoplasmic vesicle membrane|ATPase-coupled transmembrane transporter activity|xenobiotic transport|transmembrane transport|extracellular exosome|leukotriene transport|anion transmembrane transport hsa02010 ABC transporters ABCC2 38.67496883 50.74779842 26.60213925 0.524202824 -0.931802969 0.312368731 1 0.352419712 0.192697233 1244 ATP binding cassette subfamily C member 2 "GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0006855,GO:0006954,GO:0006979,GO:0007565,GO:0008514,GO:0008559,GO:0009408,GO:0009986,GO:0010629,GO:0015127,GO:0015694,GO:0015721,GO:0015722,GO:0015723,GO:0015732,GO:0016020,GO:0016324,GO:0016887,GO:0019904,GO:0030644,GO:0031427,GO:0031526,GO:0032355,GO:0033762,GO:0035690,GO:0038183,GO:0042178,GO:0042626,GO:0042910,GO:0043627,GO:0046581,GO:0046618,GO:0046685,GO:0046691,GO:0055085,GO:0070327,GO:0070633,GO:0071222,GO:0071347,GO:0071354,GO:0071356,GO:0071549,GO:0071716,GO:0097327,GO:0120188,GO:0150104,GO:1901086,GO:1904486,GO:1990961,GO:1990962" protein binding|ATP binding|plasma membrane|integral component of plasma membrane|drug transmembrane transport|inflammatory response|response to oxidative stress|female pregnancy|organic anion transmembrane transporter activity|ATPase-coupled xenobiotic transmembrane transporter activity|response to heat|cell surface|negative regulation of gene expression|bilirubin transmembrane transporter activity|mercury ion transport|bile acid and bile salt transport|canalicular bile acid transport|bilirubin transport|prostaglandin transport|membrane|apical plasma membrane|ATPase activity|protein domain specific binding|cellular chloride ion homeostasis|response to methotrexate|brush border membrane|response to estradiol|response to glucagon|cellular response to drug|bile acid signaling pathway|xenobiotic catabolic process|ATPase-coupled transmembrane transporter activity|xenobiotic transmembrane transporter activity|response to estrogen|intercellular canaliculus|drug export|response to arsenic-containing substance|intracellular canaliculus|transmembrane transport|thyroid hormone transport|transepithelial transport|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to dexamethasone stimulus|leukotriene transport|response to antineoplastic agent|regulation of bile acid secretion|transport across blood-brain barrier|benzylpenicillin metabolic process|response to 17alpha-ethynylestradiol|xenobiotic detoxification by transmembrane export across the plasma membrane|xenobiotic transport across blood-brain barrier "hsa01523,hsa01524,hsa02010,hsa04976" Antifolate resistance|Platinum drug resistance|ABC transporters|Bile secretion ABCC3 498.2572735 586.6445497 409.8699973 0.69866838 -0.517320246 0.206067758 1 5.124435475 3.734505019 8714 ATP binding cassette subfamily C member 3 "GO:0005524,GO:0005886,GO:0006855,GO:0008559,GO:0015164,GO:0015431,GO:0015432,GO:0015721,GO:0015722,GO:0015779,GO:0016020,GO:0016021,GO:0016887,GO:0042626,GO:0042908,GO:0042910,GO:0055085,GO:0071714,GO:0071716,GO:0098656,GO:0150104" ATP binding|plasma membrane|drug transmembrane transport|ATPase-coupled xenobiotic transmembrane transporter activity|glucuronoside transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|ATPase-coupled bile acid transmembrane transporter activity|bile acid and bile salt transport|canalicular bile acid transport|glucuronoside transport|membrane|integral component of membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|transmembrane transport|icosanoid transmembrane transporter activity|leukotriene transport|anion transmembrane transport|transport across blood-brain barrier "hsa01523,hsa02010,hsa04976" Antifolate resistance|ABC transporters|Bile secretion ABCC4 550.5411139 523.7172797 577.3649481 1.102436315 0.140695318 0.727358369 1 3.362630914 3.866772684 10257 ATP binding cassette subfamily C member 4 "GO:0002576,GO:0005515,GO:0005524,GO:0005886,GO:0010243,GO:0014070,GO:0015216,GO:0015431,GO:0015562,GO:0015662,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016404,GO:0016887,GO:0031088,GO:0032310,GO:0038183,GO:0042493,GO:0042626,GO:0042908,GO:0042910,GO:0048661,GO:0055085,GO:0055114,GO:0060271,GO:0070730,GO:0071716,GO:0098591,GO:0098656,GO:0140115,GO:0150104" "platelet degranulation|protein binding|ATP binding|plasma membrane|response to organonitrogen compound|response to organic cyclic compound|purine nucleotide transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|efflux transmembrane transporter activity|ion transmembrane transporter activity, phosphorylative mechanism|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATPase activity|platelet dense granule membrane|prostaglandin secretion|bile acid signaling pathway|response to drug|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|positive regulation of smooth muscle cell proliferation|transmembrane transport|oxidation-reduction process|cilium assembly|cAMP transport|leukotriene transport|external side of apical plasma membrane|anion transmembrane transport|export across plasma membrane|transport across blood-brain barrier" "hsa01523,hsa02010,hsa04024,hsa04976" Antifolate resistance|ABC transporters|cAMP signaling pathway|Bile secretion ABCC5 1056.193314 1043.374735 1069.011892 1.024571379 0.035020497 0.922830635 1 5.51772471 5.896824175 10057 ATP binding cassette subfamily C member 5 "GO:0005524,GO:0005796,GO:0005886,GO:0005887,GO:0008514,GO:0010008,GO:0015216,GO:0015562,GO:0015865,GO:0016020,GO:0016323,GO:0016324,GO:0016887,GO:0030213,GO:0034634,GO:0034775,GO:0042626,GO:0042908,GO:0042910,GO:0055085,GO:0140115,GO:0150104" ATP binding|Golgi lumen|plasma membrane|integral component of plasma membrane|organic anion transmembrane transporter activity|endosome membrane|purine nucleotide transmembrane transporter activity|efflux transmembrane transporter activity|purine nucleotide transport|membrane|basolateral plasma membrane|apical plasma membrane|ATPase activity|hyaluronan biosynthetic process|glutathione transmembrane transporter activity|glutathione transmembrane transport|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|transmembrane transport|export across plasma membrane|transport across blood-brain barrier "hsa01523,hsa02010" Antifolate resistance|ABC transporters ABCC6 47.49781125 47.70293051 47.29269199 0.99140014 -0.012460632 1 1 0.385263139 0.398402784 368 ATP binding cassette subfamily C member 6 "GO:0005215,GO:0005524,GO:0005654,GO:0005789,GO:0005886,GO:0006855,GO:0007601,GO:0008559,GO:0015431,GO:0015867,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0016887,GO:0030504,GO:0030505,GO:0042493,GO:0042626,GO:0042908,GO:0055085,GO:0071716,GO:0098656" transporter activity|ATP binding|nucleoplasm|endoplasmic reticulum membrane|plasma membrane|drug transmembrane transport|visual perception|ATPase-coupled xenobiotic transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|ATP transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|ATPase activity|inorganic diphosphate transmembrane transporter activity|inorganic diphosphate transport|response to drug|ATPase-coupled transmembrane transporter activity|xenobiotic transport|transmembrane transport|leukotriene transport|anion transmembrane transport hsa02010 ABC transporters ABCC9 55.6768421 68.00204988 43.35163433 0.637504816 -0.649491853 0.432811939 1 0.36650675 0.243714505 10060 ATP binding cassette subfamily C member 9 "GO:0005261,GO:0005267,GO:0005524,GO:0005886,GO:0008281,GO:0008282,GO:0015272,GO:0015459,GO:0016020,GO:0016887,GO:0019829,GO:0022857,GO:0030017,GO:0031004,GO:0033198,GO:0042626,GO:0044325,GO:0051607,GO:0055085,GO:0061337,GO:0071805,GO:0098655,GO:0098662,GO:0150104,GO:1903779,GO:1990573" cation channel activity|potassium channel activity|ATP binding|plasma membrane|sulfonylurea receptor activity|inward rectifying potassium channel|ATP-activated inward rectifier potassium channel activity|potassium channel regulator activity|membrane|ATPase activity|ATPase-coupled cation transmembrane transporter activity|transmembrane transporter activity|sarcomere|potassium ion-transporting ATPase complex|response to ATP|ATPase-coupled transmembrane transporter activity|ion channel binding|defense response to virus|transmembrane transport|cardiac conduction|potassium ion transmembrane transport|cation transmembrane transport|inorganic cation transmembrane transport|transport across blood-brain barrier|regulation of cardiac conduction|potassium ion import across plasma membrane hsa02010 ABC transporters ABCD1 409.0544713 483.1190409 334.9899016 0.693389979 -0.528261108 0.220457288 1 6.668922072 4.823353955 215 ATP binding cassette subfamily D member 1 "GO:0002082,GO:0005324,GO:0005515,GO:0005524,GO:0005737,GO:0005765,GO:0005777,GO:0005778,GO:0005779,GO:0005789,GO:0005829,GO:0006635,GO:0007031,GO:0015607,GO:0015910,GO:0015916,GO:0015919,GO:0016020,GO:0016887,GO:0019899,GO:0030497,GO:0031966,GO:0031998,GO:0032000,GO:0033540,GO:0036109,GO:0036113,GO:0042626,GO:0042758,GO:0042760,GO:0042802,GO:0042803,GO:0043217,GO:0043531,GO:0043651,GO:0048471,GO:0051900,GO:0055085,GO:0055089,GO:0055092,GO:1900016,GO:1900407,GO:1903427,GO:1990535,GO:2001280" regulation of oxidative phosphorylation|long-chain fatty acid transporter activity|protein binding|ATP binding|cytoplasm|lysosomal membrane|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum membrane|cytosol|fatty acid beta-oxidation|peroxisome organization|ABC-type fatty-acyl-CoA transporter|long-chain fatty acid import into peroxisome|fatty-acyl-CoA transport|peroxisomal membrane transport|membrane|ATPase activity|enzyme binding|fatty acid elongation|mitochondrial membrane|regulation of fatty acid beta-oxidation|positive regulation of fatty acid beta-oxidation|fatty acid beta-oxidation using acyl-CoA oxidase|alpha-linolenic acid metabolic process|very long-chain fatty-acyl-CoA catabolic process|ATPase-coupled transmembrane transporter activity|long-chain fatty acid catabolic process|very long-chain fatty acid catabolic process|identical protein binding|protein homodimerization activity|myelin maintenance|ADP binding|linoleic acid metabolic process|perinuclear region of cytoplasm|regulation of mitochondrial depolarization|transmembrane transport|fatty acid homeostasis|sterol homeostasis|negative regulation of cytokine production involved in inflammatory response|regulation of cellular response to oxidative stress|negative regulation of reactive oxygen species biosynthetic process|neuron projection maintenance|positive regulation of unsaturated fatty acid biosynthetic process "hsa02010,hsa04146" ABC transporters|Peroxisome ABCD2 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.013298479 0.010772425 225 ATP binding cassette subfamily D member 2 "GO:0000038,GO:0005324,GO:0005515,GO:0005524,GO:0005777,GO:0005778,GO:0005829,GO:0006635,GO:0007031,GO:0015910,GO:0016021,GO:0016887,GO:0032000,GO:0042626,GO:0042760,GO:0042803,GO:0043217,GO:0055085,GO:1900016,GO:1903427,GO:1990535,GO:2001280" very long-chain fatty acid metabolic process|long-chain fatty acid transporter activity|protein binding|ATP binding|peroxisome|peroxisomal membrane|cytosol|fatty acid beta-oxidation|peroxisome organization|long-chain fatty acid import into peroxisome|integral component of membrane|ATPase activity|positive regulation of fatty acid beta-oxidation|ATPase-coupled transmembrane transporter activity|very long-chain fatty acid catabolic process|protein homodimerization activity|myelin maintenance|transmembrane transport|negative regulation of cytokine production involved in inflammatory response|negative regulation of reactive oxygen species biosynthetic process|neuron projection maintenance|positive regulation of unsaturated fatty acid biosynthetic process "hsa02010,hsa04146" ABC transporters|Peroxisome ABCD3 1113.487108 1053.524295 1173.44992 1.113832804 0.155532688 0.654433459 1 12.33409361 14.32990048 5825 ATP binding cassette subfamily D member 3 "GO:0005324,GO:0005515,GO:0005524,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006633,GO:0006635,GO:0007031,GO:0014070,GO:0015910,GO:0016020,GO:0016021,GO:0016887,GO:0042493,GO:0042626,GO:0042760,GO:0042803,GO:0043231,GO:0043621,GO:0055085" long-chain fatty acid transporter activity|protein binding|ATP binding|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|fatty acid biosynthetic process|fatty acid beta-oxidation|peroxisome organization|response to organic cyclic compound|long-chain fatty acid import into peroxisome|membrane|integral component of membrane|ATPase activity|response to drug|ATPase-coupled transmembrane transporter activity|very long-chain fatty acid catabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|protein self-association|transmembrane transport "hsa02010,hsa04146" ABC transporters|Peroxisome ABCD4 921.9882744 860.6826612 983.2938877 1.142458112 0.19214127 0.592157459 1 13.57537854 16.17737913 5826 ATP binding cassette subfamily D member 4 "GO:0005324,GO:0005515,GO:0005524,GO:0005765,GO:0005777,GO:0005778,GO:0005789,GO:0006635,GO:0007031,GO:0009235,GO:0015910,GO:0016021,GO:0016887,GO:0042626,GO:0042760,GO:0043190,GO:0055085,GO:1990830" long-chain fatty acid transporter activity|protein binding|ATP binding|lysosomal membrane|peroxisome|peroxisomal membrane|endoplasmic reticulum membrane|fatty acid beta-oxidation|peroxisome organization|cobalamin metabolic process|long-chain fatty acid import into peroxisome|integral component of membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|very long-chain fatty acid catabolic process|ATP-binding cassette (ABC) transporter complex|transmembrane transport|cellular response to leukemia inhibitory factor "hsa02010,hsa04146" ABC transporters|Peroxisome ABCE1 1697.143697 1887.818101 1506.469293 0.79799494 -0.325548496 0.319430821 1 24.59771726 20.47438534 6059 ATP binding cassette subfamily E member 1 "GO:0000054,GO:0005506,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005852,GO:0006413,GO:0006415,GO:0016020,GO:0016032,GO:0016887,GO:0043024,GO:0051607,GO:0060338,GO:0060698,GO:0060702" ribosomal subunit export from nucleus|iron ion binding|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|translational termination|membrane|viral process|ATPase activity|ribosomal small subunit binding|defense response to virus|regulation of type I interferon-mediated signaling pathway|endoribonuclease inhibitor activity|negative regulation of endoribonuclease activity ABCF1 1769.080124 1922.326604 1615.833643 0.840561453 -0.250574797 0.441727683 1 28.59296944 25.06944155 23 ATP binding cassette subfamily F member 1 "GO:0003723,GO:0005515,GO:0005524,GO:0005635,GO:0005654,GO:0005829,GO:0006412,GO:0006954,GO:0008135,GO:0016020,GO:0016887,GO:0055085" "RNA binding|protein binding|ATP binding|nuclear envelope|nucleoplasm|cytosol|translation|inflammatory response|translation factor activity, RNA binding|membrane|ATPase activity|transmembrane transport" ABCF2 342.183422 390.7580478 293.6087961 0.751382595 -0.412380396 0.364467677 1 4.371662605 3.426286677 10061 ATP binding cassette subfamily F member 2 "GO:0005524,GO:0016020,GO:0016887" ATP binding|membrane|ATPase activity hsa05130 Pathogenic Escherichia coli infection ABCF3 1099.287127 1093.107578 1105.466675 1.011306387 0.016220145 0.96555315 1 22.08298467 23.29466401 55324 ATP binding cassette subfamily F member 3 "GO:0005515,GO:0005524,GO:0016020,GO:0016887,GO:0045296,GO:0051607" protein binding|ATP binding|membrane|ATPase activity|cadherin binding|defense response to virus ABCG1 8.552896852 12.17947162 4.926322083 0.404477488 -1.305868687 0.399342453 1 0.053793256 0.022695415 9619 ATP binding cassette subfamily G member 1 "GO:0000139,GO:0005515,GO:0005524,GO:0005543,GO:0005739,GO:0005768,GO:0005789,GO:0005794,GO:0005886,GO:0008203,GO:0009897,GO:0010033,GO:0010745,GO:0010872,GO:0010887,GO:0015485,GO:0016021,GO:0016887,GO:0019534,GO:0032367,GO:0033344,GO:0033700,GO:0033993,GO:0034041,GO:0034204,GO:0034374,GO:0034375,GO:0034436,GO:0042632,GO:0042803,GO:0042987,GO:0043531,GO:0043691,GO:0045542,GO:0046982,GO:0050714,GO:0055037,GO:0055085,GO:0055091,GO:0090554,GO:0120009,GO:0120020,GO:0140328,GO:1901998,GO:1902004" Golgi membrane|protein binding|ATP binding|phospholipid binding|mitochondrion|endosome|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|cholesterol metabolic process|external side of plasma membrane|response to organic substance|negative regulation of macrophage derived foam cell differentiation|regulation of cholesterol esterification|negative regulation of cholesterol storage|cholesterol binding|integral component of membrane|ATPase activity|toxin transmembrane transporter activity|intracellular cholesterol transport|cholesterol efflux|phospholipid efflux|response to lipid|ATPase-coupled sterol transmembrane transporter activity|lipid translocation|low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|glycoprotein transport|cholesterol homeostasis|protein homodimerization activity|amyloid precursor protein catabolic process|ADP binding|reverse cholesterol transport|positive regulation of cholesterol biosynthetic process|protein heterodimerization activity|positive regulation of protein secretion|recycling endosome|transmembrane transport|phospholipid homeostasis|phosphatidylcholine floppase activity|intermembrane lipid transfer|cholesterol transfer activity|floppase activity|toxin transport|positive regulation of amyloid-beta formation hsa02010 ABC transporters ABCG2 43.64582824 53.79266632 33.49899016 0.622742698 -0.683291895 0.445311558 1 0.513942422 0.333840514 9429 ATP binding cassette subfamily G member 2 (Junior blood group) "GO:0005515,GO:0005524,GO:0005654,GO:0005886,GO:0006879,GO:0008514,GO:0008559,GO:0015143,GO:0015225,GO:0015562,GO:0015711,GO:0015747,GO:0015878,GO:0016021,GO:0016324,GO:0031526,GO:0031966,GO:0032217,GO:0032218,GO:0042626,GO:0042802,GO:0042803,GO:0042910,GO:0045121,GO:0046415,GO:0055085,GO:0070633,GO:0097744,GO:0098591,GO:0140115,GO:0150104,GO:1990748,GO:1990962" protein binding|ATP binding|nucleoplasm|plasma membrane|cellular iron ion homeostasis|organic anion transmembrane transporter activity|ATPase-coupled xenobiotic transmembrane transporter activity|urate transmembrane transporter activity|biotin transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transport|urate transport|biotin transport|integral component of membrane|apical plasma membrane|brush border membrane|mitochondrial membrane|riboflavin transmembrane transporter activity|riboflavin transport|ATPase-coupled transmembrane transporter activity|identical protein binding|protein homodimerization activity|xenobiotic transmembrane transporter activity|membrane raft|urate metabolic process|transmembrane transport|transepithelial transport|urate salt excretion|external side of apical plasma membrane|export across plasma membrane|transport across blood-brain barrier|cellular detoxification|xenobiotic transport across blood-brain barrier "hsa01523,hsa02010,hsa04976" Antifolate resistance|ABC transporters|Bile secretion ABCG4 79.11262564 87.28621328 70.93903799 0.812717557 -0.299174035 0.693168416 1 0.995437689 0.843858542 64137 ATP binding cassette subfamily G member 4 "GO:0005515,GO:0005524,GO:0005886,GO:0016021,GO:0016887,GO:0033344,GO:0042626,GO:0042802,GO:0042803,GO:0046982,GO:0055085,GO:1990830" protein binding|ATP binding|plasma membrane|integral component of membrane|ATPase activity|cholesterol efflux|ATPase-coupled transmembrane transporter activity|identical protein binding|protein homodimerization activity|protein heterodimerization activity|transmembrane transport|cellular response to leukemia inhibitory factor hsa02010 ABC transporters ABHD1 8.00088154 8.119647747 7.882115332 0.970745971 -0.042834281 1 1 0.233521587 0.236455031 84696 abhydrolase domain containing 1 "GO:0003674,GO:0005515,GO:0008126,GO:0008150,GO:0016021,GO:0034338,GO:0044255,GO:0047372,GO:0051792,GO:0051793" molecular_function|protein binding|acetylesterase activity|biological_process|integral component of membrane|short-chain carboxylesterase activity|cellular lipid metabolic process|acylglycerol lipase activity|medium-chain fatty acid biosynthetic process|medium-chain fatty acid catabolic process ABHD10 641.6847534 625.2128765 658.1566303 1.052692059 0.074083471 0.850974444 1 11.82405772 12.9832619 55347 "abhydrolase domain containing 10, depalmitoylase" "GO:0002084,GO:0004553,GO:0005739,GO:0005759,GO:0005829,GO:0008474,GO:0018215,GO:0019391,GO:0052695,GO:0102390" "protein depalmitoylation|hydrolase activity, hydrolyzing O-glycosyl compounds|mitochondrion|mitochondrial matrix|cytosol|palmitoyl-(protein) hydrolase activity|protein phosphopantetheinylation|glucuronoside catabolic process|cellular glucuronidation|mycophenolic acid acyl-glucuronide esterase activity" ABHD11 319.044554 391.7730038 246.3161041 0.628721483 -0.669507034 0.149284138 1 12.63816596 8.288163011 83451 abhydrolase domain containing 11 "GO:0003674,GO:0005575,GO:0005739,GO:0008150,GO:0016787" molecular_function|cellular_component|mitochondrion|biological_process|hydrolase activity ABHD12 2273.606766 2331.353859 2215.859673 0.950460465 -0.073301477 0.819848274 1 38.19956275 37.87113998 26090 "abhydrolase domain containing 12, lysophospholipase" "GO:0002084,GO:0004620,GO:0004622,GO:0005789,GO:0005886,GO:0006660,GO:0007628,GO:0008474,GO:0009395,GO:0010996,GO:0016020,GO:0016021,GO:0018215,GO:0032281,GO:0032839,GO:0046464,GO:0046475,GO:0047372,GO:0050727,GO:0052651" protein depalmitoylation|phospholipase activity|lysophospholipase activity|endoplasmic reticulum membrane|plasma membrane|phosphatidylserine catabolic process|adult walking behavior|palmitoyl-(protein) hydrolase activity|phospholipid catabolic process|response to auditory stimulus|membrane|integral component of membrane|protein phosphopantetheinylation|AMPA glutamate receptor complex|dendrite cytoplasm|acylglycerol catabolic process|glycerophospholipid catabolic process|acylglycerol lipase activity|regulation of inflammatory response|monoacylglycerol catabolic process ABHD13 297.0475729 302.4568786 291.6382673 0.964230897 -0.052549436 0.918959866 1 2.282236874 2.295396373 84945 abhydrolase domain containing 13 "GO:0002084,GO:0008474,GO:0016020,GO:0016021,GO:0018215,GO:0032839" protein depalmitoylation|palmitoyl-(protein) hydrolase activity|membrane|integral component of membrane|protein phosphopantetheinylation|dendrite cytoplasm ABHD14A 101.7116025 116.7199364 86.70326866 0.742831699 -0.428892714 0.529342032 1 5.545453108 4.296782745 25864 abhydrolase domain containing 14A "GO:0005737,GO:0016021,GO:0016787" cytoplasm|integral component of membrane|hydrolase activity ABHD14B 862.8696879 894.1762081 831.5631676 0.929976843 -0.104733301 0.774640034 1 24.40025349 23.66913587 84836 abhydrolase domain containing 14B "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0016787,GO:0045944,GO:0050427,GO:0070062" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|hydrolase activity|positive regulation of transcription by RNA polymerase II|3'-phosphoadenosine 5'-phosphosulfate metabolic process|extracellular exosome ABHD15 453.3441111 513.56772 393.1205022 0.765469649 -0.38558292 0.358028159 1 7.448566226 5.947255389 116236 abhydrolase domain containing 15 "GO:0005515,GO:0005576,GO:0016020,GO:0034338,GO:0044255,GO:0047372" protein binding|extracellular region|membrane|short-chain carboxylesterase activity|cellular lipid metabolic process|acylglycerol lipase activity ABHD16A 447.4825051 449.625494 445.3395163 0.990467672 -0.013818207 0.979717103 1 9.798599435 10.12325645 7920 "abhydrolase domain containing 16A, phospholipase" "GO:0004620,GO:0004622,GO:0005515,GO:0006660,GO:0008474,GO:0016020,GO:0016021,GO:0018215,GO:0047372,GO:0052651,GO:0098734,GO:1905344" phospholipase activity|lysophospholipase activity|protein binding|phosphatidylserine catabolic process|palmitoyl-(protein) hydrolase activity|membrane|integral component of membrane|protein phosphopantetheinylation|acylglycerol lipase activity|monoacylglycerol catabolic process|macromolecule depalmitoylation|prostaglandin catabolic process ABHD16B 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.103428449 0.174546156 140701 abhydrolase domain containing 16B "GO:0004620,GO:0005654,GO:0006660,GO:0008474,GO:0016020,GO:0018215,GO:0047372,GO:0052651,GO:0098734" phospholipase activity|nucleoplasm|phosphatidylserine catabolic process|palmitoyl-(protein) hydrolase activity|membrane|protein phosphopantetheinylation|acylglycerol lipase activity|monoacylglycerol catabolic process|macromolecule depalmitoylation ABHD17A 766.4934082 704.3794421 828.6073743 1.176365074 0.234335856 0.528200691 1 6.633383012 8.139413756 81926 "abhydrolase domain containing 17A, depalmitoylase" "GO:0002084,GO:0005515,GO:0005886,GO:0008474,GO:0010008,GO:0016020,GO:0016607,GO:0018215,GO:0043197,GO:0043231,GO:0055038,GO:0072657,GO:0098978,GO:0099031,GO:0099033,GO:0099175,GO:1902817,GO:1905668" protein depalmitoylation|protein binding|plasma membrane|palmitoyl-(protein) hydrolase activity|endosome membrane|membrane|nuclear speck|protein phosphopantetheinylation|dendritic spine|intracellular membrane-bounded organelle|recycling endosome membrane|protein localization to membrane|glutamatergic synapse|anchored component of postsynaptic density membrane|anchored component of postsynaptic recycling endosome membrane|regulation of postsynapse organization|negative regulation of protein localization to microtubule|positive regulation of protein localization to endosome ABHD17B 353.8432914 379.5935322 328.0930507 0.864327295 -0.210350374 0.642966035 1 4.588322978 4.136643918 51104 "abhydrolase domain containing 17B, depalmitoylase" "GO:0002084,GO:0005886,GO:0008474,GO:0010008,GO:0016020,GO:0018215,GO:0043197,GO:0055038,GO:0098978,GO:0099031,GO:0099033,GO:0099175,GO:1902473,GO:1902817,GO:1902950,GO:1905668" protein depalmitoylation|plasma membrane|palmitoyl-(protein) hydrolase activity|endosome membrane|membrane|protein phosphopantetheinylation|dendritic spine|recycling endosome membrane|glutamatergic synapse|anchored component of postsynaptic density membrane|anchored component of postsynaptic recycling endosome membrane|regulation of postsynapse organization|regulation of protein localization to synapse|negative regulation of protein localization to microtubule|regulation of dendritic spine maintenance|positive regulation of protein localization to endosome ABHD17C 253.606864 296.3671428 210.8465851 0.711437115 -0.491191854 0.325612924 1 6.357454579 4.717758591 58489 "abhydrolase domain containing 17C, depalmitoylase" "GO:0002084,GO:0005515,GO:0005886,GO:0008474,GO:0010008,GO:0018215,GO:0043197,GO:0055038,GO:0098839,GO:0098978,GO:0099175,GO:1902817,GO:1905668" protein depalmitoylation|protein binding|plasma membrane|palmitoyl-(protein) hydrolase activity|endosome membrane|protein phosphopantetheinylation|dendritic spine|recycling endosome membrane|postsynaptic density membrane|glutamatergic synapse|regulation of postsynapse organization|negative regulation of protein localization to microtubule|positive regulation of protein localization to endosome ABHD18 158.0349778 127.884452 188.1855036 1.471527622 0.557314623 0.339794996 1 2.448732078 3.758595754 80167 abhydrolase domain containing 18 GO:0005576 extracellular region ABHD2 2485.727366 2452.13362 2519.321113 1.027399605 0.038997425 0.903923 1 27.41543427 29.37990951 11057 "abhydrolase domain containing 2, acylglycerol lipase" "GO:0001669,GO:0003707,GO:0007340,GO:0008126,GO:0009611,GO:0016021,GO:0030336,GO:0032570,GO:0033878,GO:0034338,GO:0036126,GO:0042562,GO:0043401,GO:0044255,GO:0046464,GO:0047372,GO:0048240,GO:0051792,GO:0051793,GO:0097524" acrosomal vesicle|steroid hormone receptor activity|acrosome reaction|acetylesterase activity|response to wounding|integral component of membrane|negative regulation of cell migration|response to progesterone|hormone-sensitive lipase activity|short-chain carboxylesterase activity|sperm flagellum|hormone binding|steroid hormone mediated signaling pathway|cellular lipid metabolic process|acylglycerol catabolic process|acylglycerol lipase activity|sperm capacitation|medium-chain fatty acid biosynthetic process|medium-chain fatty acid catabolic process|sperm plasma membrane ABHD3 344.3105734 300.4269666 388.1941801 1.292141596 0.369764173 0.41567907 1 5.104181824 6.879425529 171586 "abhydrolase domain containing 3, phospholipase" "GO:0004623,GO:0005575,GO:0005886,GO:0006656,GO:0008126,GO:0008970,GO:0016021,GO:0034338,GO:0044255,GO:0046470,GO:0047372,GO:0051792,GO:0051793,GO:0052739,GO:0052740,GO:0102567,GO:0102568" "phospholipase A2 activity|cellular_component|plasma membrane|phosphatidylcholine biosynthetic process|acetylesterase activity|phospholipase A1 activity|integral component of membrane|short-chain carboxylesterase activity|cellular lipid metabolic process|phosphatidylcholine metabolic process|acylglycerol lipase activity|medium-chain fatty acid biosynthetic process|medium-chain fatty acid catabolic process|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" ABHD4 820.6705808 1040.329868 601.0112941 0.577712236 -0.791577043 0.03088087 0.785916967 17.26943223 10.40652077 63874 "abhydrolase domain containing 4, N-acyl phospholipase B" "GO:0004622,GO:0005515,GO:0005739,GO:0005789,GO:0005811,GO:0006654,GO:0016042,GO:0016787,GO:0036152,GO:0042171,GO:0052689,GO:0055088,GO:0070292" lysophospholipase activity|protein binding|mitochondrion|endoplasmic reticulum membrane|lipid droplet|phosphatidic acid biosynthetic process|lipid catabolic process|hydrolase activity|phosphatidylethanolamine acyl-chain remodeling|lysophosphatidic acid acyltransferase activity|carboxylic ester hydrolase activity|lipid homeostasis|N-acylphosphatidylethanolamine metabolic process ABHD5 432.4538823 398.8776956 466.030069 1.168353293 0.22447659 0.599193255 1 3.311761988 4.03598212 51099 "abhydrolase domain containing 5, lysophosphatidic acid acyltransferase" "GO:0003841,GO:0004806,GO:0005515,GO:0005654,GO:0005739,GO:0005811,GO:0005829,GO:0006631,GO:0006654,GO:0010891,GO:0010898,GO:0030154,GO:0042171,GO:0043231,GO:0051006,GO:0052689,GO:0055088" 1-acylglycerol-3-phosphate O-acyltransferase activity|triglyceride lipase activity|protein binding|nucleoplasm|mitochondrion|lipid droplet|cytosol|fatty acid metabolic process|phosphatidic acid biosynthetic process|negative regulation of sequestering of triglyceride|positive regulation of triglyceride catabolic process|cell differentiation|lysophosphatidic acid acyltransferase activity|intracellular membrane-bounded organelle|positive regulation of lipoprotein lipase activity|carboxylic ester hydrolase activity|lipid homeostasis hsa04923 Regulation of lipolysis in adipocytes ABHD6 287.9844765 322.7559979 253.2129551 0.784533693 -0.350092687 0.466573802 1 6.636805798 5.431085494 57406 "abhydrolase domain containing 6, acylglycerol lipase" "GO:0004620,GO:0005515,GO:0005739,GO:0005765,GO:0005886,GO:0009395,GO:0016021,GO:0030336,GO:0031902,GO:0031966,GO:0032281,GO:0046464,GO:0046889,GO:0047372,GO:0052651,GO:0060292,GO:0098978,GO:0098982,GO:0099055,GO:0120163,GO:2000124,GO:2001311" phospholipase activity|protein binding|mitochondrion|lysosomal membrane|plasma membrane|phospholipid catabolic process|integral component of membrane|negative regulation of cell migration|late endosome membrane|mitochondrial membrane|AMPA glutamate receptor complex|acylglycerol catabolic process|positive regulation of lipid biosynthetic process|acylglycerol lipase activity|monoacylglycerol catabolic process|long-term synaptic depression|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic membrane|negative regulation of cold-induced thermogenesis|regulation of endocannabinoid signaling pathway|lysobisphosphatidic acid metabolic process hsa04723 Retrograde endocannabinoid signaling ABHD8 306.4197091 336.9653815 275.8740366 0.818701421 -0.288590696 0.541346284 1 8.357545461 7.137074357 79575 abhydrolase domain containing 8 "GO:0005515,GO:0005739,GO:0006654,GO:0042171,GO:0052689,GO:0055088,GO:0070062" protein binding|mitochondrion|phosphatidic acid biosynthetic process|lysophosphatidic acid acyltransferase activity|carboxylic ester hydrolase activity|lipid homeostasis|extracellular exosome ABI1 1379.906368 1484.880582 1274.932155 0.858609218 -0.219926433 0.512218309 1 15.31025308 13.7117803 10006 abl interactor 1 "GO:0005515,GO:0005622,GO:0005634,GO:0005783,GO:0005829,GO:0005856,GO:0007169,GO:0008092,GO:0008154,GO:0008285,GO:0014069,GO:0016032,GO:0017124,GO:0018108,GO:0030027,GO:0030296,GO:0030426,GO:0031209,GO:0032433,GO:0035591,GO:0038096,GO:0045296,GO:0048010,GO:0061098,GO:0070062" protein binding|intracellular anatomical structure|nucleus|endoplasmic reticulum|cytosol|cytoskeleton|transmembrane receptor protein tyrosine kinase signaling pathway|cytoskeletal protein binding|actin polymerization or depolymerization|negative regulation of cell population proliferation|postsynaptic density|viral process|SH3 domain binding|peptidyl-tyrosine phosphorylation|lamellipodium|protein tyrosine kinase activator activity|growth cone|SCAR complex|filopodium tip|signaling adaptor activity|Fc-gamma receptor signaling pathway involved in phagocytosis|cadherin binding|vascular endothelial growth factor receptor signaling pathway|positive regulation of protein tyrosine kinase activity|extracellular exosome "hsa05130,hsa05132" Pathogenic Escherichia coli infection|Salmonella infection ABI2 1718.891268 1555.9275 1881.855036 1.209474758 0.27438066 0.400870776 1 10.01553621 12.63534033 10152 abl interactor 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005912,GO:0007010,GO:0007399,GO:0008093,GO:0008154,GO:0010592,GO:0016032,GO:0016477,GO:0016601,GO:0017124,GO:0018108,GO:0019900,GO:0030027,GO:0031209,GO:0031267,GO:0031625,GO:0032433,GO:0035591,GO:0042802,GO:0043197,GO:0061001,GO:0070064,GO:0070309,GO:2000601" protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|adherens junction|cytoskeleton organization|nervous system development|cytoskeletal anchor activity|actin polymerization or depolymerization|positive regulation of lamellipodium assembly|viral process|cell migration|Rac protein signal transduction|SH3 domain binding|peptidyl-tyrosine phosphorylation|kinase binding|lamellipodium|SCAR complex|small GTPase binding|ubiquitin protein ligase binding|filopodium tip|signaling adaptor activity|identical protein binding|dendritic spine|regulation of dendritic spine morphogenesis|proline-rich region binding|lens fiber cell morphogenesis|positive regulation of Arp2/3 complex-mediated actin nucleation hsa04810 Regulation of actin cytoskeleton ABI3 3.552345889 7.104691779 0 0 #NAME? 0.089820349 1 0.204796571 0 51225 ABI family member 3 "GO:0005515,GO:0005622,GO:0005737,GO:0016020,GO:0017124,GO:0018108,GO:0030027,GO:0030334,GO:0042802" protein binding|intracellular anatomical structure|cytoplasm|membrane|SH3 domain binding|peptidyl-tyrosine phosphorylation|lamellipodium|regulation of cell migration|identical protein binding ABI3BP 12.01616809 13.19442759 10.83790858 0.821400437 -0.283842381 0.889026967 1 0.090133694 0.07722502 25890 ABI family member 3 binding protein "GO:0005201,GO:0005576,GO:0005615,GO:0062023" extracellular matrix structural constituent|extracellular region|extracellular space|collagen-containing extracellular matrix ABITRAM 441.1228238 452.6703619 429.5752856 0.948980366 -0.075549856 0.862814347 1 10.69816001 10.5896656 54942 actin binding transcription modulator "GO:0003785,GO:0005515,GO:0005634,GO:0016607,GO:0030027,GO:0030425,GO:0030426,GO:0030833,GO:0032433,GO:0048813,GO:0051015,GO:0051489" actin monomer binding|protein binding|nucleus|nuclear speck|lamellipodium|dendrite|growth cone|regulation of actin filament polymerization|filopodium tip|dendrite morphogenesis|actin filament binding|regulation of filopodium assembly ABL1 3023.525861 3451.865248 2595.186473 0.75182149 -0.411537942 0.19608642 1 25.00712307 19.61075872 25 "ABL proto-oncogene 1, non-receptor tyrosine kinase" "GO:0000278,GO:0000287,GO:0000400,GO:0000405,GO:0001784,GO:0001843,GO:0001922,GO:0001934,GO:0002322,GO:0002333,GO:0003677,GO:0003713,GO:0003785,GO:0004515,GO:0004672,GO:0004713,GO:0004715,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006298,GO:0006355,GO:0006464,GO:0006468,GO:0006897,GO:0006914,GO:0006974,GO:0006975,GO:0006979,GO:0007050,GO:0007173,GO:0007204,GO:0007229,GO:0008022,GO:0008630,GO:0009791,GO:0010506,GO:0010595,GO:0015629,GO:0016301,GO:0016604,GO:0017124,GO:0018108,GO:0019905,GO:0021587,GO:0022408,GO:0030035,GO:0030036,GO:0030100,GO:0030145,GO:0030155,GO:0030425,GO:0030514,GO:0030516,GO:0031113,GO:0031252,GO:0031965,GO:0032489,GO:0032729,GO:0032743,GO:0032956,GO:0032991,GO:0033690,GO:0034446,GO:0034599,GO:0035791,GO:0038083,GO:0038096,GO:0038189,GO:0038191,GO:0042169,GO:0042770,GO:0042981,GO:0043025,GO:0043065,GO:0043123,GO:0043124,GO:0043542,GO:0045184,GO:0045580,GO:0045930,GO:0045931,GO:0045944,GO:0046632,GO:0046777,GO:0046875,GO:0048471,GO:0048536,GO:0048538,GO:0048668,GO:0050731,GO:0050798,GO:0050852,GO:0050853,GO:0050885,GO:0051015,GO:0051019,GO:0051149,GO:0051281,GO:0051353,GO:0051444,GO:0051496,GO:0051882,GO:0051894,GO:0060020,GO:0060563,GO:0070064,GO:0070301,GO:0070373,GO:0070374,GO:0071103,GO:0071222,GO:0071901,GO:0072359,GO:0090050,GO:0090135,GO:0097100,GO:0098794,GO:1900026,GO:1900272,GO:1900275,GO:1901216,GO:1902036,GO:1903053,GO:1903351,GO:1904528,GO:1904531,GO:1905244,GO:1905555,GO:1990051,GO:1990837,GO:2000096,GO:2000145,GO:2000249,GO:2000251,GO:2000352,GO:2000773,GO:2001020" "mitotic cell cycle|magnesium ion binding|four-way junction DNA binding|bubble DNA binding|phosphotyrosine residue binding|neural tube closure|B-1 B cell homeostasis|positive regulation of protein phosphorylation|B cell proliferation involved in immune response|transitional one stage B cell differentiation|DNA binding|transcription coactivator activity|actin monomer binding|nicotinate-nucleotide adenylyltransferase activity|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein kinase C binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|cytosol|mismatch repair|regulation of transcription, DNA-templated|cellular protein modification process|protein phosphorylation|endocytosis|autophagy|cellular response to DNA damage stimulus|DNA damage induced protein phosphorylation|response to oxidative stress|cell cycle arrest|epidermal growth factor receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|integrin-mediated signaling pathway|protein C-terminus binding|intrinsic apoptotic signaling pathway in response to DNA damage|post-embryonic development|regulation of autophagy|positive regulation of endothelial cell migration|actin cytoskeleton|kinase activity|nuclear body|SH3 domain binding|peptidyl-tyrosine phosphorylation|syntaxin binding|cerebellum morphogenesis|negative regulation of cell-cell adhesion|microspike assembly|actin cytoskeleton organization|regulation of endocytosis|manganese ion binding|regulation of cell adhesion|dendrite|negative regulation of BMP signaling pathway|regulation of axon extension|regulation of microtubule polymerization|cell leading edge|nuclear membrane|regulation of Cdc42 protein signal transduction|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|regulation of actin cytoskeleton organization|protein-containing complex|positive regulation of osteoblast proliferation|substrate adhesion-dependent cell spreading|cellular response to oxidative stress|platelet-derived growth factor receptor-beta signaling pathway|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|neuropilin signaling pathway|neuropilin binding|SH2 domain binding|signal transduction in response to DNA damage|regulation of apoptotic process|neuronal cell body|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|endothelial cell migration|establishment of protein localization|regulation of T cell differentiation|negative regulation of mitotic cell cycle|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|alpha-beta T cell differentiation|protein autophosphorylation|ephrin receptor binding|perinuclear region of cytoplasm|spleen development|thymus development|collateral sprouting|positive regulation of peptidyl-tyrosine phosphorylation|activated T cell proliferation|T cell receptor signaling pathway|B cell receptor signaling pathway|neuromuscular process controlling balance|actin filament binding|mitogen-activated protein kinase binding|positive regulation of muscle cell differentiation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of oxidoreductase activity|negative regulation of ubiquitin-protein transferase activity|positive regulation of stress fiber assembly|mitochondrial depolarization|positive regulation of focal adhesion assembly|Bergmann glial cell differentiation|neuroepithelial cell differentiation|proline-rich region binding|cellular response to hydrogen peroxide|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|DNA conformation change|cellular response to lipopolysaccharide|negative regulation of protein serine/threonine kinase activity|circulatory system development|positive regulation of cell migration involved in sprouting angiogenesis|actin filament branching|supercoiled DNA binding|postsynapse|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of long-term synaptic potentiation|negative regulation of phospholipase C activity|positive regulation of neuron death|regulation of hematopoietic stem cell differentiation|regulation of extracellular matrix organization|cellular response to dopamine|positive regulation of microtubule binding|positive regulation of actin filament binding|regulation of modification of synaptic structure|positive regulation of blood vessel branching|activation of protein kinase C activity|sequence-specific double-stranded DNA binding|positive regulation of Wnt signaling pathway, planar cell polarity pathway|regulation of cell motility|regulation of actin cytoskeleton reorganization|positive regulation of actin cytoskeleton reorganization|negative regulation of endothelial cell apoptotic process|negative regulation of cellular senescence|regulation of response to DNA damage stimulus" "hsa04012,hsa04014,hsa04110,hsa04360,hsa04722,hsa05130,hsa05200,hsa05206,hsa05220,hsa05416" ErbB signaling pathway|Ras signaling pathway|Cell cycle|Axon guidance|Neurotrophin signaling pathway|Pathogenic Escherichia coli infection|Pathways in cancer|MicroRNAs in cancer|Chronic myeloid leukemia|Viral myocarditis ABL2 2205.757379 1970.029535 2441.485224 1.239314021 0.309541788 0.334108633 1 6.46169588 8.353025495 27 "ABL proto-oncogene 2, non-receptor tyrosine kinase" "GO:0000287,GO:0001784,GO:0003785,GO:0004672,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005829,GO:0006464,GO:0007155,GO:0007165,GO:0007204,GO:0010506,GO:0010863,GO:0010976,GO:0015629,GO:0018108,GO:0030100,GO:0030145,GO:0030155,GO:0035024,GO:0035640,GO:0051015,GO:0051353,GO:0071300,GO:2000145,GO:2000249" magnesium ion binding|phosphotyrosine residue binding|actin monomer binding|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|cytosol|cellular protein modification process|cell adhesion|signal transduction|positive regulation of cytosolic calcium ion concentration|regulation of autophagy|positive regulation of phospholipase C activity|positive regulation of neuron projection development|actin cytoskeleton|peptidyl-tyrosine phosphorylation|regulation of endocytosis|manganese ion binding|regulation of cell adhesion|negative regulation of Rho protein signal transduction|exploration behavior|actin filament binding|positive regulation of oxidoreductase activity|cellular response to retinoic acid|regulation of cell motility|regulation of actin cytoskeleton reorganization "hsa04012,hsa04014,hsa05416" ErbB signaling pathway|Ras signaling pathway|Viral myocarditis ABLIM1 614.4294 580.5548139 648.3039861 1.116697288 0.159238156 0.684535038 1 2.524950902 2.941063007 3983 actin binding LIM protein 1 "GO:0001725,GO:0003779,GO:0005515,GO:0005737,GO:0007010,GO:0007601,GO:0009887,GO:0015629,GO:0030027,GO:0030032,GO:0046872,GO:0051015,GO:0060271" stress fiber|actin binding|protein binding|cytoplasm|cytoskeleton organization|visual perception|animal organ morphogenesis|actin cytoskeleton|lamellipodium|lamellipodium assembly|metal ion binding|actin filament binding|cilium assembly hsa04360 Axon guidance ABLIM3 1605.116238 1456.461815 1753.770661 1.20413089 0.267992223 0.415388432 1 11.8269445 14.85464188 22885 actin binding LIM protein family member 3 "GO:0001725,GO:0005515,GO:0005737,GO:0006351,GO:0015629,GO:0030027,GO:0030032,GO:0030036,GO:0045944,GO:0046872,GO:0051015,GO:0060271,GO:0098978,GO:1903955" "stress fiber|protein binding|cytoplasm|transcription, DNA-templated|actin cytoskeleton|lamellipodium|lamellipodium assembly|actin cytoskeleton organization|positive regulation of transcription by RNA polymerase II|metal ion binding|actin filament binding|cilium assembly|glutamatergic synapse|positive regulation of protein targeting to mitochondrion" hsa04360 Axon guidance ABR 4787.30901 4607.900096 4966.717924 1.07787014 0.108183376 0.736028824 1 18.83110499 21.17181915 29 ABR activator of RhoGEF and GTPase "GO:0005085,GO:0005096,GO:0005515,GO:0005829,GO:0007186,GO:0007264,GO:0016020,GO:0030424,GO:0043065,GO:0043197,GO:0050804,GO:0051056,GO:0090630,GO:0098685,GO:0098978" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|membrane|axon|positive regulation of apoptotic process|dendritic spine|modulation of chemical synaptic transmission|regulation of small GTPase mediated signal transduction|activation of GTPase activity|Schaffer collateral - CA1 synapse|glutamatergic synapse ABRACL 638.4266014 671.9008511 604.9523518 0.900359556 -0.151426843 0.696808921 1 35.41041393 33.25545631 58527 ABRA C-terminal like GO:0032970 regulation of actin filament-based process ABRAXAS1 346.1568928 359.2944128 333.0193728 0.926870446 -0.109560395 0.813881641 1 4.154564953 4.016617884 84142 "abraxas 1, BRCA1 A complex subunit" "GO:0005515,GO:0005634,GO:0005654,GO:0006302,GO:0006303,GO:0006325,GO:0008017,GO:0008608,GO:0010212,GO:0016579,GO:0016604,GO:0031593,GO:0045739,GO:0070531,GO:0070536,GO:0072425,GO:0090307" protein binding|nucleus|nucleoplasm|double-strand break repair|double-strand break repair via nonhomologous end joining|chromatin organization|microtubule binding|attachment of spindle microtubules to kinetochore|response to ionizing radiation|protein deubiquitination|nuclear body|polyubiquitin modification-dependent protein binding|positive regulation of DNA repair|BRCA1-A complex|protein K63-linked deubiquitination|signal transduction involved in G2 DNA damage checkpoint|mitotic spindle assembly hsa03440 Homologous recombination ABRAXAS2 399.3732955 393.8029157 404.9436752 1.02829019 0.04024746 0.932057733 1 6.713136462 7.200407871 23172 "abraxas 2, BRISC complex subunit" "GO:0000278,GO:0002931,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0007059,GO:0008017,GO:0008608,GO:0016579,GO:0030496,GO:0031593,GO:0031616,GO:0036449,GO:0051301,GO:0070536,GO:0070552,GO:0090307" mitotic cell cycle|response to ischemia|protein binding|nucleus|cytoplasm|centrosome|cytosol|chromosome segregation|microtubule binding|attachment of spindle microtubules to kinetochore|protein deubiquitination|midbody|polyubiquitin modification-dependent protein binding|spindle pole centrosome|microtubule minus-end|cell division|protein K63-linked deubiquitination|BRISC complex|mitotic spindle assembly ABT1 436.0628897 443.5357582 428.5900212 0.966303197 -0.04945216 0.9124232 1 7.632864917 7.69337537 29777 activator of basal transcription 1 "GO:0000447,GO:0000472,GO:0000480,GO:0003677,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005730,GO:0006366,GO:0034462,GO:0045893" "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA binding|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleolus|transcription by RNA polymerase II|small-subunit processome assembly|positive regulation of transcription, DNA-templated" ABTB1 583.4814078 418.161859 748.8009566 1.79069645 0.8405208 0.033337603 0.820898508 9.914992027 18.51954327 80325 ankyrin repeat and BTB domain containing 1 "GO:0000151,GO:0003746,GO:0005515,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006414" ubiquitin ligase complex|translation elongation factor activity|protein binding|nucleolus|cytoplasm|cytosol|plasma membrane|translational elongation ABTB2 718.4690677 890.1163843 546.8217512 0.614326127 -0.702923352 0.061781193 1 9.190877619 5.88941149 25841 ankyrin repeat and BTB domain containing 2 "GO:0003674,GO:0046982,GO:0097237" molecular_function|protein heterodimerization activity|cellular response to toxic substance ACAA1 955.1443279 1039.314912 870.9737442 0.838026795 -0.254931722 0.473585291 1 25.04169067 21.88958264 30 acetyl-CoA acyltransferase 1 "GO:0000038,GO:0003985,GO:0003988,GO:0005515,GO:0005576,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0008206,GO:0008775,GO:0010124,GO:0016020,GO:0016401,GO:0033540,GO:0035580,GO:0036109,GO:0043312,GO:0050633" very long-chain fatty acid metabolic process|acetyl-CoA C-acetyltransferase activity|acetyl-CoA C-acyltransferase activity|protein binding|extracellular region|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|bile acid metabolic process|acetate CoA-transferase activity|phenylacetate catabolic process|membrane|palmitoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA oxidase|specific granule lumen|alpha-linolenic acid metabolic process|neutrophil degranulation|acetyl-CoA C-myristoyltransferase activity "hsa00071,hsa00280,hsa00592,hsa01040,hsa03320,hsa04146" "Fatty acid degradation|Valine, leucine and isoleucine degradation|alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|Peroxisome" ACAA2 1125.527524 1135.735729 1115.31932 0.982023627 -0.026170359 0.942304465 1 19.658581 20.13678035 10449 acetyl-CoA acyltransferase 2 "GO:0003723,GO:0003985,GO:0003986,GO:0003988,GO:0005515,GO:0005739,GO:0005759,GO:0006635,GO:0006695,GO:0016290,GO:0047617,GO:0071456,GO:0102991,GO:1901029,GO:1902109" RNA binding|acetyl-CoA C-acetyltransferase activity|acetyl-CoA hydrolase activity|acetyl-CoA C-acyltransferase activity|protein binding|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|cholesterol biosynthetic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|cellular response to hypoxia|myristoyl-CoA hydrolase activity|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|negative regulation of mitochondrial membrane permeability involved in apoptotic process "hsa00062,hsa00071,hsa00280" "Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation" ACACA 1897.408711 2040.061496 1754.755926 0.860148544 -0.217342266 0.502071905 1 9.183354181 8.239307712 31 acetyl-CoA carboxylase alpha "GO:0001650,GO:0001894,GO:0003989,GO:0005515,GO:0005524,GO:0005829,GO:0006084,GO:0006633,GO:0006853,GO:0015629,GO:0019538,GO:0031325,GO:0042802,GO:0045540,GO:0046872,GO:0046949,GO:0051289,GO:0055088,GO:0071380,GO:2001295" fibrillar center|tissue homeostasis|acetyl-CoA carboxylase activity|protein binding|ATP binding|cytosol|acetyl-CoA metabolic process|fatty acid biosynthetic process|carnitine shuttle|actin cytoskeleton|protein metabolic process|positive regulation of cellular metabolic process|identical protein binding|regulation of cholesterol biosynthetic process|metal ion binding|fatty-acyl-CoA biosynthetic process|protein homotetramerization|lipid homeostasis|cellular response to prostaglandin E stimulus|malonyl-CoA biosynthetic process "hsa00061,hsa00620,hsa00640,hsa04152,hsa04910,hsa04922" Fatty acid biosynthesis|Pyruvate metabolism|Propanoate metabolism|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway ACACB 173.5765218 112.6601125 234.4929311 2.081419288 1.057567616 0.062413942 1 0.562872374 1.222040048 32 acetyl-CoA carboxylase beta "GO:0003989,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006084,GO:0006633,GO:0006853,GO:0009374,GO:0010629,GO:0010884,GO:0010906,GO:0014070,GO:0031325,GO:0031667,GO:0031999,GO:0042493,GO:0042802,GO:0043086,GO:0045540,GO:0046872,GO:0051289,GO:0060421,GO:0097009,GO:2001295" acetyl-CoA carboxylase activity|protein binding|ATP binding|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|acetyl-CoA metabolic process|fatty acid biosynthetic process|carnitine shuttle|biotin binding|negative regulation of gene expression|positive regulation of lipid storage|regulation of glucose metabolic process|response to organic cyclic compound|positive regulation of cellular metabolic process|response to nutrient levels|negative regulation of fatty acid beta-oxidation|response to drug|identical protein binding|negative regulation of catalytic activity|regulation of cholesterol biosynthetic process|metal ion binding|protein homotetramerization|positive regulation of heart growth|energy homeostasis|malonyl-CoA biosynthetic process "hsa00061,hsa00620,hsa00640,hsa04152,hsa04910,hsa04920,hsa04922,hsa04931" Fatty acid biosynthesis|Pyruvate metabolism|Propanoate metabolism|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance ACAD10 531.5038855 569.3902983 493.6174727 0.866922872 -0.206024449 0.610767145 1 7.035279316 6.361766655 80724 acyl-CoA dehydrogenase family member 10 "GO:0003995,GO:0005739,GO:0005759,GO:0006635,GO:0016787,GO:0050660" acyl-CoA dehydrogenase activity|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|hydrolase activity|flavin adenine dinucleotide binding ACAD11 306.5830126 348.1298972 265.0361281 0.761313895 -0.393436685 0.403285784 1 5.456995098 4.333444611 84129 acyl-CoA dehydrogenase family member 11 "GO:0003995,GO:0004466,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005777,GO:0006635,GO:0017099,GO:0031966,GO:0033539,GO:0050660,GO:0070991" acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|peroxisome|fatty acid beta-oxidation|very-long-chain-acyl-CoA dehydrogenase activity|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|flavin adenine dinucleotide binding|medium-chain-acyl-CoA dehydrogenase activity ACAD8 598.647602 613.0334049 584.261799 0.953066822 -0.069350726 0.863133787 1 7.870210217 7.823941845 27034 acyl-CoA dehydrogenase family member 8 "GO:0003995,GO:0005759,GO:0006574,GO:0006629,GO:0009083,GO:0050660,GO:0055114" acyl-CoA dehydrogenase activity|mitochondrial matrix|valine catabolic process|lipid metabolic process|branched-chain amino acid catabolic process|flavin adenine dinucleotide binding|oxidation-reduction process hsa00280 "Valine, leucine and isoleucine degradation" ACAD9 836.4456979 906.3556798 766.5357161 0.845733891 -0.241724301 0.507667014 1 16.75929819 14.78446089 28976 acyl-CoA dehydrogenase family member 9 "GO:0000062,GO:0001676,GO:0004466,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0017099,GO:0030425,GO:0031966,GO:0032981,GO:0050660,GO:0051791,GO:0055114,GO:0070991" fatty-acyl-CoA binding|long-chain fatty acid metabolic process|long-chain-acyl-CoA dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|very-long-chain-acyl-CoA dehydrogenase activity|dendrite|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|flavin adenine dinucleotide binding|medium-chain fatty acid metabolic process|oxidation-reduction process|medium-chain-acyl-CoA dehydrogenase activity ACADL 21.49494625 21.31407534 21.67581716 1.016971969 0.024279915 1 1 0.332353055 0.352553141 33 acyl-CoA dehydrogenase long chain "GO:0000062,GO:0001659,GO:0003995,GO:0004466,GO:0005515,GO:0005739,GO:0005759,GO:0006635,GO:0016401,GO:0019254,GO:0031966,GO:0033539,GO:0042413,GO:0042758,GO:0042802,GO:0044242,GO:0045717,GO:0046322,GO:0050660,GO:0055114,GO:0090181,GO:0120162" "fatty-acyl-CoA binding|temperature homeostasis|acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|protein binding|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|palmitoyl-CoA oxidase activity|carnitine metabolic process, CoA-linked|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|carnitine catabolic process|long-chain fatty acid catabolic process|identical protein binding|cellular lipid catabolic process|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|flavin adenine dinucleotide binding|oxidation-reduction process|regulation of cholesterol metabolic process|positive regulation of cold-induced thermogenesis" "hsa00071,hsa03320" Fatty acid degradation|PPAR signaling pathway ACADM 584.3882379 648.5568638 520.2196119 0.802118736 -0.318112283 0.4193966 1 13.84785716 11.58609715 34 acyl-CoA dehydrogenase medium chain "GO:0003995,GO:0005634,GO:0005739,GO:0005759,GO:0006635,GO:0019216,GO:0019254,GO:0030424,GO:0031966,GO:0033539,GO:0042802,GO:0045329,GO:0050660,GO:0051791,GO:0051793,GO:0055114,GO:0070991" "acyl-CoA dehydrogenase activity|nucleus|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|regulation of lipid metabolic process|carnitine metabolic process, CoA-linked|axon|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|identical protein binding|carnitine biosynthetic process|flavin adenine dinucleotide binding|medium-chain fatty acid metabolic process|medium-chain fatty acid catabolic process|oxidation-reduction process|medium-chain-acyl-CoA dehydrogenase activity" "hsa00071,hsa00280,hsa03320" "Fatty acid degradation|Valine, leucine and isoleucine degradation|PPAR signaling pathway" ACADS 271.8072857 260.8436839 282.7708875 1.084062621 0.116448096 0.817628809 1 6.608710549 7.472863174 35 acyl-CoA dehydrogenase short chain "GO:0003995,GO:0004085,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005813,GO:0006635,GO:0033539,GO:0046359,GO:0050660" acyl-CoA dehydrogenase activity|butyryl-CoA dehydrogenase activity|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|centrosome|fatty acid beta-oxidation|fatty acid beta-oxidation using acyl-CoA dehydrogenase|butyrate catabolic process|flavin adenine dinucleotide binding "hsa00071,hsa00280,hsa00410,hsa00640,hsa00650" "Fatty acid degradation|Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism" ACADSB 278.2951359 333.9205136 222.6697581 0.666834618 -0.584599093 0.227693971 1 2.891911083 2.011495212 36 acyl-CoA dehydrogenase short/branched chain "GO:0003853,GO:0005739,GO:0005759,GO:0006550,GO:0006631,GO:0009083,GO:0016937,GO:0042802,GO:0050660,GO:0055114,GO:0102035" 2-methylacyl-CoA dehydrogenase activity|mitochondrion|mitochondrial matrix|isoleucine catabolic process|fatty acid metabolic process|branched-chain amino acid catabolic process|short-branched-chain-acyl-CoA dehydrogenase activity|identical protein binding|flavin adenine dinucleotide binding|oxidation-reduction process|isobutyryl-CoA:FAD oxidoreductase activity "hsa00071,hsa00280" "Fatty acid degradation|Valine, leucine and isoleucine degradation" ACADVL 5715.939036 5484.822053 5947.056018 1.084275107 0.11673085 0.718390328 1 113.7538443 128.6534685 37 acyl-CoA dehydrogenase very long chain "GO:0000062,GO:0001659,GO:0003995,GO:0004466,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005759,GO:0006635,GO:0009409,GO:0015980,GO:0017099,GO:0030855,GO:0031314,GO:0031966,GO:0033539,GO:0036498,GO:0042645,GO:0042802,GO:0045717,GO:0046322,GO:0050660,GO:0090181" fatty-acyl-CoA binding|temperature homeostasis|acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|protein binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|response to cold|energy derivation by oxidation of organic compounds|very-long-chain-acyl-CoA dehydrogenase activity|epithelial cell differentiation|extrinsic component of mitochondrial inner membrane|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|IRE1-mediated unfolded protein response|mitochondrial nucleoid|identical protein binding|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|flavin adenine dinucleotide binding|regulation of cholesterol metabolic process hsa00071 Fatty acid degradation ACAP1 16.68739037 29.43372308 3.941057666 0.133895996 -2.900815276 0.023993684 0.684653464 0.588517267 0.082194495 9744 "ArfGAP with coiled-coil, ankyrin repeat and PH domains 1" "GO:0005096,GO:0005515,GO:0015031,GO:0016020,GO:0043547,GO:0046872,GO:0055038" GTPase activator activity|protein binding|protein transport|membrane|positive regulation of GTPase activity|metal ion binding|recycling endosome membrane hsa04144 Endocytosis ACAP2 1289.268969 1215.91725 1362.620688 1.120652485 0.164338967 0.628207114 1 7.838839005 9.163019973 23527 "ArfGAP with coiled-coil, ankyrin repeat and PH domains 2" "GO:0001726,GO:0005096,GO:0010008,GO:0016020,GO:0030029,GO:0032456,GO:0043547,GO:0046872,GO:1990090" ruffle|GTPase activator activity|endosome membrane|membrane|actin filament-based process|endocytic recycling|positive regulation of GTPase activity|metal ion binding|cellular response to nerve growth factor stimulus hsa04144 Endocytosis ACAP3 828.6190063 775.4263598 881.8116528 1.137195869 0.185480763 0.612592502 1 6.14210347 7.285650456 116983 "ArfGAP with coiled-coil, ankyrin repeat and PH domains 3" "GO:0001764,GO:0005096,GO:0010975,GO:0030426,GO:0043547,GO:0046872" neuron migration|GTPase activator activity|regulation of neuron projection development|growth cone|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis ACAT1 1751.17538 1809.666492 1692.684268 0.935357026 -0.096410948 0.768525975 1 40.48287265 39.49705046 38 acetyl-CoA acetyltransferase 1 "GO:0003985,GO:0005739,GO:0005759,GO:0006085,GO:0006550,GO:0006635,GO:0009083,GO:0015936,GO:0015937,GO:0016453,GO:0030955,GO:0034435,GO:0046356,GO:0046951,GO:0046952,GO:0070062,GO:1902224,GO:1902860" acetyl-CoA C-acetyltransferase activity|mitochondrion|mitochondrial matrix|acetyl-CoA biosynthetic process|isoleucine catabolic process|fatty acid beta-oxidation|branched-chain amino acid catabolic process|coenzyme A metabolic process|coenzyme A biosynthetic process|C-acetyltransferase activity|potassium ion binding|cholesterol esterification|acetyl-CoA catabolic process|ketone body biosynthetic process|ketone body catabolic process|extracellular exosome|ketone body metabolic process|propionyl-CoA biosynthetic process "hsa00071,hsa00072,hsa00280,hsa00310,hsa00380,hsa00620,hsa00630,hsa00640,hsa00650,hsa00900,hsa04975" "Fatty acid degradation|Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism|Butanoate metabolism|Terpenoid backbone biosynthesis|Fat digestion and absorption" ACAT2 807.4061298 773.3964479 841.4158117 1.087948896 0.121610791 0.742417518 1 21.51005036 24.40989171 39 acetyl-CoA acetyltransferase 2 "GO:0003985,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006629,GO:0006635,GO:0006695,GO:0070062" acetyl-CoA C-acetyltransferase activity|protein binding|cytoplasm|mitochondrion|cytosol|lipid metabolic process|fatty acid beta-oxidation|cholesterol biosynthetic process|extracellular exosome "hsa00071,hsa00072,hsa00280,hsa00310,hsa00380,hsa00620,hsa00630,hsa00640,hsa00650,hsa00900,hsa04975" "Fatty acid degradation|Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism|Butanoate metabolism|Terpenoid backbone biosynthesis|Fat digestion and absorption" ACBD3 1334.369683 1369.175601 1299.563765 0.949157847 -0.075280065 0.824887545 1 19.3481903 19.15555425 64746 acyl-CoA binding domain containing 3 "GO:0000062,GO:0000139,GO:0005515,GO:0005739,GO:0005794,GO:0006694,GO:0016020,GO:0016032,GO:0034237" fatty-acyl-CoA binding|Golgi membrane|protein binding|mitochondrion|Golgi apparatus|steroid biosynthetic process|membrane|viral process|protein kinase A regulatory subunit binding hsa05132 Salmonella infection ACBD4 325.3354497 316.6662621 334.0046372 1.054752833 0.076904963 0.873735837 1 4.228322975 4.65194727 79777 acyl-CoA binding domain containing 4 "GO:0000062,GO:0008289" fatty-acyl-CoA binding|lipid binding ACBD5 702.1825133 888.0864723 516.2785543 0.581338158 -0.782550486 0.038709832 0.901500108 7.558132556 4.583099274 91452 acyl-CoA binding domain containing 5 "GO:0000062,GO:0003674,GO:0005654,GO:0005777,GO:0005778,GO:0008289,GO:0009062,GO:0016020,GO:0016021,GO:0016236,GO:0030242,GO:0035973" fatty-acyl-CoA binding|molecular_function|nucleoplasm|peroxisome|peroxisomal membrane|lipid binding|fatty acid catabolic process|membrane|integral component of membrane|macroautophagy|autophagy of peroxisome|aggrephagy ACBD6 926.8349244 922.5949753 931.0748736 1.009191355 0.013199754 0.973856439 1 36.13780416 38.04093751 84320 acyl-CoA binding domain containing 6 "GO:0000062,GO:0005515,GO:0005829,GO:0006637,GO:0008289" fatty-acyl-CoA binding|protein binding|cytosol|acyl-CoA metabolic process|lipid binding ACBD7 260.776382 247.6492563 273.9035078 1.106013852 0.145369454 0.77459728 1 3.721828242 4.293711131 414149 acyl-CoA binding domain containing 7 "GO:0000062,GO:0005515,GO:0008289" fatty-acyl-CoA binding|protein binding|lipid binding ACCS 131.9551623 129.914364 133.9959607 1.031417594 0.04462856 0.955636832 1 1.958828289 2.107399305 84680 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) "GO:0005515,GO:0016847,GO:0030170,GO:0042218,GO:0042802" protein binding|1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|1-aminocyclopropane-1-carboxylate biosynthetic process|identical protein binding ACD 467.9234013 398.8776956 536.969107 1.346199883 0.428892636 0.302452241 1 9.797162039 13.75706436 65057 ACD shelterin complex subunit and telomerase recruitment factor "GO:0000723,GO:0000781,GO:0000783,GO:0005515,GO:0005654,GO:0005697,GO:0006886,GO:0007004,GO:0016233,GO:0016604,GO:0031848,GO:0032202,GO:0032211,GO:0032212,GO:0042162,GO:0044877,GO:0051973,GO:0060381,GO:0070182,GO:0070187,GO:0070198,GO:0070200" "telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|protein binding|nucleoplasm|telomerase holoenzyme complex|intracellular protein transport|telomere maintenance via telomerase|telomere capping|nuclear body|protection from non-homologous end joining at telomere|telomere assembly|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|telomeric DNA binding|protein-containing complex binding|positive regulation of telomerase activity|positive regulation of single-stranded telomeric DNA binding|DNA polymerase binding|shelterin complex|protein localization to chromosome, telomeric region|establishment of protein localization to telomere" ACE 11.95678498 9.134603715 14.77896625 1.617909951 0.694131313 0.630281003 1 0.085609817 0.14447538 1636 angiotensin I converting enzyme "GO:0001822,GO:0001974,GO:0002003,GO:0002019,GO:0002446,GO:0002474,GO:0003081,GO:0003084,GO:0004175,GO:0004180,GO:0005576,GO:0005615,GO:0005764,GO:0005768,GO:0005886,GO:0006508,GO:0007283,GO:0008217,GO:0008237,GO:0008238,GO:0008240,GO:0008241,GO:0008270,GO:0009897,GO:0010608,GO:0010629,GO:0014910,GO:0016021,GO:0019229,GO:0031404,GO:0031434,GO:0031711,GO:0032091,GO:0032092,GO:0032943,GO:0042447,GO:0043171,GO:0050435,GO:0050482,GO:0051019,GO:0060047,GO:0060177,GO:0060218,GO:0061098,GO:0070062,GO:0070573,GO:0071838,GO:0097746,GO:1900086,GO:1902033,GO:1903597,GO:2000170" kidney development|blood vessel remodeling|angiotensin maturation|regulation of renal output by angiotensin|neutrophil mediated immunity|antigen processing and presentation of peptide antigen via MHC class I|regulation of systemic arterial blood pressure by renin-angiotensin|positive regulation of systemic arterial blood pressure|endopeptidase activity|carboxypeptidase activity|extracellular region|extracellular space|lysosome|endosome|plasma membrane|proteolysis|spermatogenesis|regulation of blood pressure|metallopeptidase activity|exopeptidase activity|tripeptidyl-peptidase activity|peptidyl-dipeptidase activity|zinc ion binding|external side of plasma membrane|posttranscriptional regulation of gene expression|negative regulation of gene expression|regulation of smooth muscle cell migration|integral component of membrane|regulation of vasoconstriction|chloride ion binding|mitogen-activated protein kinase kinase binding|bradykinin receptor binding|negative regulation of protein binding|positive regulation of protein binding|mononuclear cell proliferation|hormone catabolic process|peptide catabolic process|amyloid-beta metabolic process|arachidonic acid secretion|mitogen-activated protein kinase binding|heart contraction|regulation of angiotensin metabolic process|hematopoietic stem cell differentiation|positive regulation of protein tyrosine kinase activity|extracellular exosome|metallodipeptidase activity|cell proliferation in bone marrow|blood vessel diameter maintenance|positive regulation of peptidyl-tyrosine autophosphorylation|regulation of hematopoietic stem cell proliferation|negative regulation of gap junction assembly|positive regulation of peptidyl-cysteine S-nitrosylation "hsa04614,hsa04924,hsa05142,hsa05171,hsa05410" Renin-angiotensin system|Renin secretion|Chagas disease|Coronavirus disease - COVID-19|Hypertrophic cardiomyopathy ACER2 31.76599374 16.23929549 47.29269199 2.912237912 1.542128219 0.117283574 1 0.138113019 0.419543889 340485 alkaline ceramidase 2 "GO:0000139,GO:0001953,GO:0005794,GO:0006919,GO:0006974,GO:0008284,GO:0010506,GO:0010942,GO:0017040,GO:0030148,GO:0030173,GO:0030330,GO:0032526,GO:0033629,GO:0035690,GO:0042981,GO:0046512,GO:0046514,GO:0046872,GO:0071633,GO:0090285,GO:0102121" "Golgi membrane|negative regulation of cell-matrix adhesion|Golgi apparatus|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|positive regulation of cell population proliferation|regulation of autophagy|positive regulation of cell death|N-acylsphingosine amidohydrolase activity|sphingolipid biosynthetic process|integral component of Golgi membrane|DNA damage response, signal transduction by p53 class mediator|response to retinoic acid|negative regulation of cell adhesion mediated by integrin|cellular response to drug|regulation of apoptotic process|sphingosine biosynthetic process|ceramide catabolic process|metal ion binding|dihydroceramidase activity|negative regulation of protein glycosylation in Golgi|ceramidase activity" "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway ACER3 1054.992044 1129.645993 980.3380945 0.867827709 -0.204519443 0.55895815 1 6.495525021 5.879815553 55331 alkaline ceramidase 3 "GO:0005509,GO:0005789,GO:0008270,GO:0008284,GO:0016021,GO:0017040,GO:0030148,GO:0030173,GO:0030176,GO:0042552,GO:0043067,GO:0046512,GO:0046514,GO:0070774,GO:0071602,GO:0071633,GO:0102121" calcium ion binding|endoplasmic reticulum membrane|zinc ion binding|positive regulation of cell population proliferation|integral component of membrane|N-acylsphingosine amidohydrolase activity|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|myelination|regulation of programmed cell death|sphingosine biosynthetic process|ceramide catabolic process|phytoceramidase activity|phytosphingosine biosynthetic process|dihydroceramidase activity|ceramidase activity hsa00600 Sphingolipid metabolism ACHE 11.52353588 13.19442759 9.852644165 0.74672767 -0.421345905 0.803618457 1 0.24220776 0.188654091 43 acetylcholinesterase (Cartwright blood group) "GO:0001507,GO:0001540,GO:0001919,GO:0002076,GO:0003990,GO:0004104,GO:0005515,GO:0005518,GO:0005576,GO:0005604,GO:0005615,GO:0005634,GO:0005794,GO:0005886,GO:0006581,GO:0006656,GO:0007155,GO:0007399,GO:0007416,GO:0009986,GO:0016020,GO:0016787,GO:0017171,GO:0031225,GO:0031594,GO:0031623,GO:0032223,GO:0042136,GO:0042166,GO:0042803,GO:0042982,GO:0043083,GO:0043236,GO:0043621,GO:0045202,GO:0048471,GO:0050714,GO:0052689,GO:0060041,GO:0095500,GO:0120162" "acetylcholine catabolic process in synaptic cleft|amyloid-beta binding|regulation of receptor recycling|osteoblast development|acetylcholinesterase activity|cholinesterase activity|protein binding|collagen binding|extracellular region|basement membrane|extracellular space|nucleus|Golgi apparatus|plasma membrane|acetylcholine catabolic process|phosphatidylcholine biosynthetic process|cell adhesion|nervous system development|synapse assembly|cell surface|membrane|hydrolase activity|serine hydrolase activity|anchored component of membrane|neuromuscular junction|receptor internalization|negative regulation of synaptic transmission, cholinergic|neurotransmitter biosynthetic process|acetylcholine binding|protein homodimerization activity|amyloid precursor protein metabolic process|synaptic cleft|laminin binding|protein self-association|synapse|perinuclear region of cytoplasm|positive regulation of protein secretion|carboxylic ester hydrolase activity|retina development in camera-type eye|acetylcholine receptor signaling pathway|positive regulation of cold-induced thermogenesis" "hsa00564,hsa04725" Glycerophospholipid metabolism|Cholinergic synapse ACIN1 4385.997353 4553.092474 4218.902232 0.926601481 -0.109979106 0.731025292 1 35.34611764 34.16257817 22985 apoptotic chromatin condensation inducer 1 "GO:0003676,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006397,GO:0008380,GO:0016607,GO:0016887,GO:0019899,GO:0030218,GO:0030263,GO:0045657,GO:0061574" nucleic acid binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|mRNA processing|RNA splicing|nuclear speck|ATPase activity|enzyme binding|erythrocyte differentiation|apoptotic chromosome condensation|positive regulation of monocyte differentiation|ASAP complex "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome ACKR2 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.017191953 0.052223743 1238 atypical chemokine receptor 2 "GO:0004950,GO:0005044,GO:0005515,GO:0005654,GO:0005769,GO:0005829,GO:0005884,GO:0005886,GO:0005887,GO:0006897,GO:0006935,GO:0006954,GO:0006955,GO:0007186,GO:0007204,GO:0007275,GO:0009897,GO:0016493,GO:0019722,GO:0019957,GO:0031965,GO:0043231,GO:0055037,GO:0060326,GO:0070098" chemokine receptor activity|scavenger receptor activity|protein binding|nucleoplasm|early endosome|cytosol|actin filament|plasma membrane|integral component of plasma membrane|endocytosis|chemotaxis|inflammatory response|immune response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|multicellular organism development|external side of plasma membrane|C-C chemokine receptor activity|calcium-mediated signaling|C-C chemokine binding|nuclear membrane|intracellular membrane-bounded organelle|recycling endosome|cell chemotaxis|chemokine-mediated signaling pathway ACLY 7266.084348 6820.504107 7711.664588 1.130659034 0.177163931 0.589591502 1 77.10590887 90.93587452 47 ATP citrate lyase "GO:0003878,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0006085,GO:0006101,GO:0006107,GO:0006633,GO:0006695,GO:0008610,GO:0015936,GO:0016020,GO:0031325,GO:0035578,GO:0043312,GO:0046872,GO:0046949,GO:0070062,GO:1904813" ATP citrate synthase activity|protein binding|ATP binding|extracellular region|nucleoplasm|cytosol|plasma membrane|acetyl-CoA biosynthetic process|citrate metabolic process|oxaloacetate metabolic process|fatty acid biosynthetic process|cholesterol biosynthetic process|lipid biosynthetic process|coenzyme A metabolic process|membrane|positive regulation of cellular metabolic process|azurophil granule lumen|neutrophil degranulation|metal ion binding|fatty-acyl-CoA biosynthetic process|extracellular exosome|ficolin-1-rich granule lumen hsa00020 Citrate cycle (TCA cycle) ACO1 6798.358401 7849.669459 5747.047342 0.73213877 -0.449810972 0.16935784 1 109.5805033 83.6840376 48 aconitase 1 "GO:0003723,GO:0003994,GO:0005515,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0005829,GO:0006099,GO:0006101,GO:0006417,GO:0006879,GO:0009791,GO:0010040,GO:0030350,GO:0046872,GO:0047780,GO:0050892,GO:0051538,GO:0051539,GO:0070062" "RNA binding|aconitate hydratase activity|protein binding|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|tricarboxylic acid cycle|citrate metabolic process|regulation of translation|cellular iron ion homeostasis|post-embryonic development|response to iron(II) ion|iron-responsive element binding|metal ion binding|citrate dehydratase activity|intestinal absorption|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|extracellular exosome" "hsa00020,hsa00630" Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism ACO2 2531.51247 2450.103708 2612.921233 1.06645332 0.092820818 0.77185903 1 37.41004201 41.6146241 50 aconitase 2 "GO:0003994,GO:0005506,GO:0005739,GO:0005759,GO:0005829,GO:0006091,GO:0006099,GO:0006101,GO:0047780,GO:0051539" "aconitate hydratase activity|iron ion binding|mitochondrion|mitochondrial matrix|cytosol|generation of precursor metabolites and energy|tricarboxylic acid cycle|citrate metabolic process|citrate dehydratase activity|4 iron, 4 sulfur cluster binding" "hsa00020,hsa00630" Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism ACOT1 166.1815955 179.6472064 152.7159846 0.850088279 -0.234315426 0.688640592 1 3.479348852 3.085161711 641371 acyl-CoA thioesterase 1 "GO:0000038,GO:0001676,GO:0005829,GO:0006631,GO:0006637,GO:0016290,GO:0047617,GO:0052689,GO:0102991" very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|cytosol|fatty acid metabolic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|myristoyl-CoA hydrolase activity "hsa00062,hsa01040,hsa04913" Fatty acid elongation|Biosynthesis of unsaturated fatty acids|Ovarian steroidogenesis ACOT11 21.91334958 16.23929549 27.58740366 1.698805448 0.764520641 0.493262248 1 0.106233922 0.188244715 26027 acyl-CoA thioesterase 11 "GO:0005759,GO:0005829,GO:0006631,GO:0006637,GO:0008289,GO:0009266,GO:0009409,GO:0016290,GO:0035556,GO:0036042,GO:0047617,GO:0052689,GO:0070062,GO:0102991,GO:0120163" mitochondrial matrix|cytosol|fatty acid metabolic process|acyl-CoA metabolic process|lipid binding|response to temperature stimulus|response to cold|palmitoyl-CoA hydrolase activity|intracellular signal transduction|long-chain fatty acyl-CoA binding|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|extracellular exosome|myristoyl-CoA hydrolase activity|negative regulation of cold-induced thermogenesis ACOT13 120.307417 175.5873825 65.02745149 0.370342393 -1.43306839 0.026434618 0.720384826 2.053783254 0.793366699 55856 acyl-CoA thioesterase 13 "GO:0005515,GO:0005634,GO:0005739,GO:0005819,GO:0005829,GO:0006637,GO:0016290,GO:0046872,GO:0047617,GO:0051289,GO:0102991,GO:0120163" protein binding|nucleus|mitochondrion|spindle|cytosol|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|metal ion binding|acyl-CoA hydrolase activity|protein homotetramerization|myristoyl-CoA hydrolase activity|negative regulation of cold-induced thermogenesis ACOT2 325.6944699 307.5316584 343.8572814 1.118119946 0.161074961 0.731207622 1 8.206213695 9.570775887 10965 acyl-CoA thioesterase 2 "GO:0000038,GO:0001676,GO:0005515,GO:0005739,GO:0005759,GO:0005782,GO:0005829,GO:0006625,GO:0006631,GO:0006637,GO:0016290,GO:0047617,GO:0052689,GO:0102991" very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|protein binding|mitochondrion|mitochondrial matrix|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid metabolic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|myristoyl-CoA hydrolase activity "hsa00062,hsa01040,hsa04913" Fatty acid elongation|Biosynthesis of unsaturated fatty acids|Ovarian steroidogenesis ACOT4 110.3387282 133.9741878 86.70326866 0.64716398 -0.627796782 0.340099977 1 4.631617734 3.1265327 122970 acyl-CoA thioesterase 4 "GO:0000038,GO:0001676,GO:0004778,GO:0005777,GO:0005782,GO:0005829,GO:0006104,GO:0006625,GO:0006631,GO:0006633,GO:0006637,GO:0016290,GO:0019605,GO:0032788,GO:0032789,GO:0043648,GO:0043649,GO:0044466,GO:0046459,GO:0047617,GO:0052689,GO:0102991" very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|succinyl-CoA hydrolase activity|peroxisome|peroxisomal matrix|cytosol|succinyl-CoA metabolic process|protein targeting to peroxisome|fatty acid metabolic process|fatty acid biosynthetic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|butyrate metabolic process|saturated monocarboxylic acid metabolic process|unsaturated monocarboxylic acid metabolic process|dicarboxylic acid metabolic process|dicarboxylic acid catabolic process|glutaryl-CoA hydrolase activity|short-chain fatty acid metabolic process|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|myristoyl-CoA hydrolase activity "hsa00062,hsa01040,hsa04913" Fatty acid elongation|Biosynthesis of unsaturated fatty acids|Ovarian steroidogenesis ACOT7 2648.11364 2675.423933 2620.803348 0.979584325 -0.029758406 0.926774657 1 58.15484286 59.42150449 11332 acyl-CoA thioesterase 7 "GO:0000062,GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0006631,GO:0006637,GO:0015937,GO:0016290,GO:0036042,GO:0036114,GO:0036116,GO:0042803,GO:0047617,GO:0051792,GO:0052689,GO:0070062,GO:0102991,GO:1900535" fatty-acyl-CoA binding|protein binding|nucleoplasm|mitochondrion|cytosol|fatty acid metabolic process|acyl-CoA metabolic process|coenzyme A biosynthetic process|palmitoyl-CoA hydrolase activity|long-chain fatty acyl-CoA binding|medium-chain fatty-acyl-CoA catabolic process|long-chain fatty-acyl-CoA catabolic process|protein homodimerization activity|acyl-CoA hydrolase activity|medium-chain fatty acid biosynthetic process|carboxylic ester hydrolase activity|extracellular exosome|myristoyl-CoA hydrolase activity|palmitic acid biosynthetic process "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ACOT8 653.5673095 629.2727004 677.8619186 1.077214883 0.107306068 0.782579447 1 26.66982622 29.96666831 10005 acyl-CoA thioesterase 8 "GO:0003986,GO:0004778,GO:0005515,GO:0005782,GO:0005829,GO:0006625,GO:0006637,GO:0006699,GO:0009062,GO:0016032,GO:0016289,GO:0016290,GO:0016559,GO:0033540,GO:0033882,GO:0036109,GO:0043649,GO:0044466,GO:0045225,GO:0047603,GO:0047617,GO:0047994,GO:0052689,GO:0052815,GO:0052816,GO:0102991" acetyl-CoA hydrolase activity|succinyl-CoA hydrolase activity|protein binding|peroxisomal matrix|cytosol|protein targeting to peroxisome|acyl-CoA metabolic process|bile acid biosynthetic process|fatty acid catabolic process|viral process|CoA hydrolase activity|palmitoyl-CoA hydrolase activity|peroxisome fission|fatty acid beta-oxidation using acyl-CoA oxidase|choloyl-CoA hydrolase activity|alpha-linolenic acid metabolic process|dicarboxylic acid catabolic process|glutaryl-CoA hydrolase activity|negative regulation of CD4 production|acetoacetyl-CoA hydrolase activity|acyl-CoA hydrolase activity|hydroxymethylglutaryl-CoA hydrolase activity|carboxylic ester hydrolase activity|medium-chain acyl-CoA hydrolase activity|long-chain acyl-CoA hydrolase activity|myristoyl-CoA hydrolase activity "hsa00120,hsa04146" Primary bile acid biosynthesis|Peroxisome ACOT9 2270.143741 1959.879975 2580.407507 1.316615068 0.396833614 0.215129504 1 22.98772735 31.56972424 23597 acyl-CoA thioesterase 9 "GO:0003986,GO:0005739,GO:0005759,GO:0006637,GO:0047617,GO:0052689" acetyl-CoA hydrolase activity|mitochondrion|mitochondrial matrix|acyl-CoA metabolic process|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity ACOX1 576.6154862 588.6744617 564.5565107 0.959030071 -0.060352043 0.882578484 1 3.896273492 3.897602889 51 acyl-CoA oxidase 1 "GO:0000038,GO:0003997,GO:0005504,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006091,GO:0006625,GO:0006629,GO:0006693,GO:0007283,GO:0009062,GO:0016020,GO:0016401,GO:0019216,GO:0019395,GO:0030165,GO:0033540,GO:0036109,GO:0042803,GO:0047485,GO:0050660,GO:0050665,GO:0055088,GO:0071949" very long-chain fatty acid metabolic process|acyl-CoA oxidase activity|fatty acid binding|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|generation of precursor metabolites and energy|protein targeting to peroxisome|lipid metabolic process|prostaglandin metabolic process|spermatogenesis|fatty acid catabolic process|membrane|palmitoyl-CoA oxidase activity|regulation of lipid metabolic process|fatty acid oxidation|PDZ domain binding|fatty acid beta-oxidation using acyl-CoA oxidase|alpha-linolenic acid metabolic process|protein homodimerization activity|protein N-terminus binding|flavin adenine dinucleotide binding|hydrogen peroxide biosynthetic process|lipid homeostasis|FAD binding "hsa00071,hsa00410,hsa00592,hsa00640,hsa01040,hsa03320,hsa04024,hsa04146" Fatty acid degradation|beta-Alanine metabolism|alpha-Linolenic acid metabolism|Propanoate metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|cAMP signaling pathway|Peroxisome ACOX2 12.52364607 14.20938356 10.83790858 0.762728977 -0.390757585 0.812815113 1 0.307282301 0.244468958 8309 acyl-CoA oxidase 2 "GO:0000038,GO:0003997,GO:0005504,GO:0005515,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006699,GO:0010942,GO:0016401,GO:0033540,GO:0033791,GO:0042803,GO:0043231,GO:0050660,GO:0055088,GO:0071949,GO:1902884" "very long-chain fatty acid metabolic process|acyl-CoA oxidase activity|fatty acid binding|protein binding|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|bile acid biosynthetic process|positive regulation of cell death|palmitoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA oxidase|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|protein homodimerization activity|intracellular membrane-bounded organelle|flavin adenine dinucleotide binding|lipid homeostasis|FAD binding|positive regulation of response to oxidative stress" "hsa00120,hsa03320,hsa04146" Primary bile acid biosynthesis|PPAR signaling pathway|Peroxisome ACOX3 310.3513642 268.9633316 351.7393967 1.307759666 0.387097433 0.409237794 1 2.719513656 3.709668585 8310 "acyl-CoA oxidase 3, pristanoyl" "GO:0003997,GO:0005504,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0016020,GO:0016402,GO:0033540,GO:0050660,GO:0055088,GO:0071949" acyl-CoA oxidase activity|fatty acid binding|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|membrane|pristanoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA oxidase|flavin adenine dinucleotide binding|lipid homeostasis|FAD binding "hsa00071,hsa00410,hsa00592,hsa00640,hsa01040,hsa03320,hsa04024,hsa04146" Fatty acid degradation|beta-Alanine metabolism|alpha-Linolenic acid metabolism|Propanoate metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|cAMP signaling pathway|Peroxisome ACP1 1248.422312 1252.455665 1244.388958 0.993559287 -0.009322037 0.980753485 1 35.14263769 36.42034641 52 acid phosphatase 1 "GO:0003993,GO:0004725,GO:0004726,GO:0005515,GO:0005737,GO:0009898,GO:0035335,GO:0070062" acid phosphatase activity|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|cytoplasm|cytoplasmic side of plasma membrane|peptidyl-tyrosine dephosphorylation|extracellular exosome "hsa00730,hsa00740,hsa04520" Thiamine metabolism|Riboflavin metabolism|Adherens junction ACP2 832.686995 683.0653667 982.3086233 1.438088756 0.524152719 0.150670664 1 15.34139739 23.01264511 53 "acid phosphatase 2, lysosomal" "GO:0003993,GO:0005515,GO:0005764,GO:0005765,GO:0007040,GO:0016020,GO:0016021,GO:0016311,GO:0016791,GO:0043202,GO:0070062" acid phosphatase activity|protein binding|lysosome|lysosomal membrane|lysosome organization|membrane|integral component of membrane|dephosphorylation|phosphatase activity|lysosomal lumen|extracellular exosome "hsa00740,hsa04142" Riboflavin metabolism|Lysosome ACP5 14.55355801 18.26920743 10.83790858 0.593233649 -0.753327664 0.562628766 1 0.460792284 0.28513262 54 "acid phosphatase 5, tartrate resistant" "GO:0001503,GO:0003993,GO:0005764,GO:0005829,GO:0006771,GO:0008198,GO:0008199,GO:0016021,GO:0016311,GO:0045453" ossification|acid phosphatase activity|lysosome|cytosol|riboflavin metabolic process|ferrous iron binding|ferric iron binding|integral component of membrane|dephosphorylation|bone resorption "hsa00740,hsa04142,hsa04380,hsa05323" Riboflavin metabolism|Lysosome|Osteoclast differentiation|Rheumatoid arthritis ACP6 426.3911164 422.2216828 430.56055 1.019749974 0.02821547 0.95308903 1 1.669975691 1.776314177 51205 "acid phosphatase 6, lysophosphatidic" "GO:0002244,GO:0003993,GO:0005737,GO:0005739,GO:0005759,GO:0006644,GO:0006654,GO:0016311,GO:0016791,GO:0052642,GO:2001311" hematopoietic progenitor cell differentiation|acid phosphatase activity|cytoplasm|mitochondrion|mitochondrial matrix|phospholipid metabolic process|phosphatidic acid biosynthetic process|dephosphorylation|phosphatase activity|lysophosphatidic acid phosphatase activity|lysobisphosphatidic acid metabolic process ACP7 72.78535741 58.86744617 86.70326866 1.472855955 0.558616342 0.462441397 1 0.740727572 1.137980225 390928 "acid phosphatase 7, tartrate resistant (putative)" "GO:0003993,GO:0005576,GO:0016311,GO:0046872" acid phosphatase activity|extracellular region|dephosphorylation|metal ion binding ACRBP 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.080951085 0 84519 acrosin binding protein "GO:0001669,GO:0001675,GO:0002080,GO:0003674,GO:0005576,GO:0005634,GO:0007286,GO:0008150,GO:0009566" acrosomal vesicle|acrosome assembly|acrosomal membrane|molecular_function|extracellular region|nucleus|spermatid development|biological_process|fertilization ACSF2 506.4147776 504.4331163 508.3964389 1.007856983 0.011290933 0.983330469 1 10.84370026 11.39967168 80221 acyl-CoA synthetase family member 2 "GO:0005515,GO:0005524,GO:0005759,GO:0006631,GO:0006637,GO:0031956,GO:0047760" protein binding|ATP binding|mitochondrial matrix|fatty acid metabolic process|acyl-CoA metabolic process|medium-chain fatty acid-CoA ligase activity|butyrate-CoA ligase activity ACSF3 446.1557879 426.2815067 466.030069 1.093244867 0.128616574 0.763744215 1 1.338976339 1.526884826 197322 acyl-CoA synthetase family member 3 "GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006631,GO:0006633,GO:0016405,GO:0016878,GO:0031957,GO:0035338,GO:0090409,GO:0090410" protein binding|ATP binding|mitochondrion|mitochondrial matrix|fatty acid metabolic process|fatty acid biosynthetic process|CoA-ligase activity|acid-thiol ligase activity|very long-chain fatty acid-CoA ligase activity|long-chain fatty-acyl-CoA biosynthetic process|malonyl-CoA synthetase activity|malonate catabolic process "hsa00061,hsa00280" "Fatty acid biosynthesis|Valine, leucine and isoleucine degradation" ACSL1 1008.788536 1136.750685 880.8263884 0.774863301 -0.367986277 0.295763878 1 12.30968825 9.949198066 2180 acyl-CoA synthetase long chain family member 1 "GO:0000038,GO:0001676,GO:0004467,GO:0005524,GO:0005739,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005886,GO:0007584,GO:0008610,GO:0010747,GO:0014070,GO:0015908,GO:0016020,GO:0016021,GO:0019216,GO:0019432,GO:0033211,GO:0034201,GO:0035338,GO:0036109,GO:0042178,GO:0042493,GO:0043651,GO:0044539,GO:0047676,GO:0050197,GO:0071902,GO:0090434,GO:0120162" very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|mitochondrion|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|response to nutrient|lipid biosynthetic process|positive regulation of long-chain fatty acid import across plasma membrane|response to organic cyclic compound|fatty acid transport|membrane|integral component of membrane|regulation of lipid metabolic process|triglyceride biosynthetic process|adiponectin-activated signaling pathway|response to oleic acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|xenobiotic catabolic process|response to drug|linoleic acid metabolic process|long-chain fatty acid import into cell|arachidonate-CoA ligase activity|phytanate-CoA ligase activity|positive regulation of protein serine/threonine kinase activity|oleoyl-CoA ligase activity|positive regulation of cold-induced thermogenesis "hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920" Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL3 1129.251338 1053.524295 1204.978381 1.143759462 0.193783679 0.575597662 1 9.567381915 11.41415433 2181 acyl-CoA synthetase long chain family member 3 "GO:0001676,GO:0004467,GO:0005515,GO:0005524,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0005886,GO:0006633,GO:0007420,GO:0007584,GO:0014070,GO:0016020,GO:0016021,GO:0019901,GO:0019904,GO:0030182,GO:0034379,GO:0035336,GO:0035338,GO:0042998,GO:0044539,GO:0047676,GO:0048471,GO:0051047,GO:2001247" long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|protein binding|ATP binding|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|plasma membrane|fatty acid biosynthetic process|brain development|response to nutrient|response to organic cyclic compound|membrane|integral component of membrane|protein kinase binding|protein domain specific binding|neuron differentiation|very-low-density lipoprotein particle assembly|long-chain fatty-acyl-CoA metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of Golgi to plasma membrane protein transport|long-chain fatty acid import into cell|arachidonate-CoA ligase activity|perinuclear region of cytoplasm|positive regulation of secretion|positive regulation of phosphatidylcholine biosynthetic process "hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920" Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL4 2761.675632 2457.208399 3066.142864 1.247815556 0.3194047 0.315999644 1 24.79556424 32.27307301 2182 acyl-CoA synthetase long chain family member 4 "GO:0001676,GO:0004467,GO:0005524,GO:0005737,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005811,GO:0005886,GO:0006629,GO:0007584,GO:0015908,GO:0016020,GO:0016021,GO:0019432,GO:0030182,GO:0031957,GO:0032024,GO:0035336,GO:0035338,GO:0043025,GO:0044233,GO:0047676,GO:0060136,GO:0060996,GO:0070062,GO:0070672" long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|cytoplasm|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|plasma membrane|lipid metabolic process|response to nutrient|fatty acid transport|membrane|integral component of membrane|triglyceride biosynthetic process|neuron differentiation|very long-chain fatty acid-CoA ligase activity|positive regulation of insulin secretion|long-chain fatty-acyl-CoA metabolic process|long-chain fatty-acyl-CoA biosynthetic process|neuronal cell body|mitochondria-associated endoplasmic reticulum membrane|arachidonate-CoA ligase activity|embryonic process involved in female pregnancy|dendritic spine development|extracellular exosome|response to interleukin-15 "hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920" Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL5 13.52375626 15.22433953 11.823173 0.776596776 -0.364762376 0.820851526 1 0.204416513 0.165587477 51703 acyl-CoA synthetase long chain family member 5 "GO:0001676,GO:0004467,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0005886,GO:0008610,GO:0010747,GO:0016020,GO:0016021,GO:0035338,GO:0047676" long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|protein binding|ATP binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|lipid biosynthetic process|positive regulation of long-chain fatty acid import across plasma membrane|membrane|integral component of membrane|long-chain fatty-acyl-CoA biosynthetic process|arachidonate-CoA ligase activity "hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920" Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL6 19.00209366 19.2841634 18.72002391 0.970745971 -0.042834281 1 1 0.143291497 0.145091492 23305 acyl-CoA synthetase long chain family member 6 "GO:0000038,GO:0001676,GO:0004467,GO:0005524,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005886,GO:0006637,GO:0008610,GO:0016020,GO:0016021,GO:0035338,GO:0042803,GO:0047676" very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|acyl-CoA metabolic process|lipid biosynthetic process|membrane|integral component of membrane|long-chain fatty-acyl-CoA biosynthetic process|protein homodimerization activity|arachidonate-CoA ligase activity "hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920" Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSM3 6.522984915 8.119647747 4.926322083 0.606716232 -0.720906186 0.726457076 1 0.124089171 0.078529969 6296 acyl-CoA synthetase medium chain family member 3 "GO:0001676,GO:0004321,GO:0004467,GO:0005524,GO:0005739,GO:0005759,GO:0006633,GO:0006637,GO:0008217,GO:0015645,GO:0031956,GO:0042632,GO:0046872,GO:0047760,GO:0050218" long-chain fatty acid metabolic process|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|fatty acid biosynthetic process|acyl-CoA metabolic process|regulation of blood pressure|fatty acid ligase activity|medium-chain fatty acid-CoA ligase activity|cholesterol homeostasis|metal ion binding|butyrate-CoA ligase activity|propionate-CoA ligase activity hsa00650 Butanoate metabolism ACSS1 460.0264402 397.8627396 522.1901408 1.312488174 0.392304424 0.347871607 1 5.069268977 6.939955161 84532 acyl-CoA synthetase short chain family member 1 "GO:0003987,GO:0005515,GO:0005524,GO:0005759,GO:0006069,GO:0006085,GO:0016208,GO:0019413,GO:0019427,GO:0019542,GO:0050218" acetate-CoA ligase activity|protein binding|ATP binding|mitochondrial matrix|ethanol oxidation|acetyl-CoA biosynthetic process|AMP binding|acetate biosynthetic process|acetyl-CoA biosynthetic process from acetate|propionate biosynthetic process|propionate-CoA ligase activity "hsa00010,hsa00620,hsa00630,hsa00640" Glycolysis / Gluconeogenesis|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism ACSS2 1054.168845 972.3278177 1136.009872 1.168340401 0.224460671 0.521150658 1 15.25084354 18.58571144 55902 acyl-CoA synthetase short chain family member 2 "GO:0003987,GO:0005524,GO:0005654,GO:0005737,GO:0005759,GO:0005829,GO:0006069,GO:0008610,GO:0016208,GO:0019413,GO:0019427,GO:0019542,GO:0043231,GO:0050218" acetate-CoA ligase activity|ATP binding|nucleoplasm|cytoplasm|mitochondrial matrix|cytosol|ethanol oxidation|lipid biosynthetic process|AMP binding|acetate biosynthetic process|acetyl-CoA biosynthetic process from acetate|propionate biosynthetic process|intracellular membrane-bounded organelle|propionate-CoA ligase activity "hsa00010,hsa00620,hsa00630,hsa00640" Glycolysis / Gluconeogenesis|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism ACTA2 123.6303953 65.97213794 181.2886526 2.747957824 1.458359862 0.022857574 0.661990495 1.848039851 5.297089669 59 "actin alpha 2, smooth muscle" "GO:0005524,GO:0005615,GO:0005737,GO:0005829,GO:0005869,GO:0006936,GO:0008217,GO:0009615,GO:0010628,GO:0014829,GO:0019901,GO:0030027,GO:0030175,GO:0030485,GO:0032991,GO:0044297,GO:0045893,GO:0070062,GO:0072144,GO:0090131" "ATP binding|extracellular space|cytoplasm|cytosol|dynactin complex|muscle contraction|regulation of blood pressure|response to virus|positive regulation of gene expression|vascular associated smooth muscle contraction|protein kinase binding|lamellipodium|filopodium|smooth muscle contractile fiber|protein-containing complex|cell body|positive regulation of transcription, DNA-templated|extracellular exosome|glomerular mesangial cell development|mesenchyme migration" "hsa04270,hsa04371,hsa04926" Vascular smooth muscle contraction|Apelin signaling pathway|Relaxin signaling pathway ACTB 119255.3311 135385.9916 103124.6707 0.761708575 -0.392688958 0.438146667 1 3784.118576 3006.557479 60 actin beta "GO:0000079,GO:0000785,GO:0001738,GO:0001895,GO:0005200,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005911,GO:0005912,GO:0005925,GO:0007163,GO:0007409,GO:0015629,GO:0016020,GO:0016579,GO:0019894,GO:0019901,GO:0021762,GO:0022898,GO:0030027,GO:0030424,GO:0030957,GO:0031492,GO:0031982,GO:0032091,GO:0032991,GO:0034329,GO:0034333,GO:0035267,GO:0035633,GO:0036464,GO:0038096,GO:0042802,GO:0043044,GO:0043296,GO:0045176,GO:0045202,GO:0045815,GO:0048013,GO:0048156,GO:0048870,GO:0050998,GO:0051621,GO:0051623,GO:0061024,GO:0070062,GO:0070160,GO:0070527,GO:0071896,GO:0072562,GO:0072749,GO:0097433,GO:0098793,GO:0098871,GO:0098973,GO:0098974,GO:0098978,GO:0150111,GO:1903076,GO:1990904" "regulation of cyclin-dependent protein serine/threonine kinase activity|chromatin|morphogenesis of a polarized epithelium|retina homeostasis|structural constituent of cytoskeleton|protein binding|ATP binding|extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|actin filament|plasma membrane|cell-cell junction|adherens junction|focal adhesion|establishment or maintenance of cell polarity|axonogenesis|actin cytoskeleton|membrane|protein deubiquitination|kinesin binding|protein kinase binding|substantia nigra development|regulation of transmembrane transporter activity|lamellipodium|axon|Tat protein binding|nucleosomal DNA binding|vesicle|negative regulation of protein binding|protein-containing complex|cell junction assembly|adherens junction assembly|NuA4 histone acetyltransferase complex|maintenance of blood-brain barrier|cytoplasmic ribonucleoprotein granule|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|ATP-dependent chromatin remodeling|apical junction complex|apical protein localization|synapse|positive regulation of gene expression, epigenetic|ephrin receptor signaling pathway|tau protein binding|cell motility|nitric-oxide synthase binding|regulation of norepinephrine uptake|positive regulation of norepinephrine uptake|membrane organization|extracellular exosome|tight junction|platelet aggregation|protein localization to adherens junction|blood microparticle|cellular response to cytochalasin B|dense body|presynapse|postsynaptic actin cytoskeleton|structural constituent of postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|glutamatergic synapse|regulation of transepithelial transport|regulation of protein localization to plasma membrane|ribonucleoprotein complex" "hsa04015,hsa04145,hsa04210,hsa04390,hsa04510,hsa04520,hsa04530,hsa04611,hsa04670,hsa04714,hsa04810,hsa04919,hsa04921,hsa04971,hsa05014,hsa05100,hsa05110,hsa05130,hsa05131,hsa05132,hsa05135,hsa05164,hsa05205,hsa05225,hsa05410,hsa05412,hsa05414,hsa05416,hsa05418" Rap1 signaling pathway|Phagosome|Apoptosis|Hippo signaling pathway|Focal adhesion|Adherens junction|Tight junction|Platelet activation|Leukocyte transendothelial migration|Thermogenesis|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Gastric acid secretion|Amyotrophic lateral sclerosis|Bacterial invasion of epithelial cells|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Influenza A|Proteoglycans in cancer|Hepatocellular carcinoma|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis|Fluid shear stress and atherosclerosis ACTBL2 14.61294111 22.3290313 6.896850916 0.308873718 -1.694910978 0.176417358 1 0.404755427 0.130403596 345651 actin beta like 2 "GO:0003674,GO:0005515,GO:0005524,GO:0005615,GO:0005737,GO:0005884,GO:0007409,GO:0008150,GO:0016020,GO:0019901,GO:0030424,GO:0035267,GO:0045202,GO:0048870,GO:0070062,GO:0098973,GO:0098974,GO:0098978" molecular_function|protein binding|ATP binding|extracellular space|cytoplasm|actin filament|axonogenesis|biological_process|membrane|protein kinase binding|axon|NuA4 histone acetyltransferase complex|synapse|cell motility|extracellular exosome|structural constituent of postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|glutamatergic synapse ACTG1 50376.78558 54845.17566 45908.39549 0.837054398 -0.256606712 0.548694768 1 1362.961072 1190.016722 71 actin gamma 1 "GO:0001525,GO:0001738,GO:0001895,GO:0005200,GO:0005515,GO:0005522,GO:0005524,GO:0005615,GO:0005634,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005911,GO:0005925,GO:0010628,GO:0016020,GO:0030335,GO:0031625,GO:0034329,GO:0035633,GO:0038096,GO:0042802,GO:0043296,GO:0048013,GO:0051492,GO:0051893,GO:0061024,GO:0070062,GO:0070527,GO:0072562,GO:0090303,GO:0097433,GO:0098973,GO:0098974,GO:0120192,GO:0150111,GO:1902396" angiogenesis|morphogenesis of a polarized epithelium|retina homeostasis|structural constituent of cytoskeleton|protein binding|profilin binding|ATP binding|extracellular space|nucleus|cytosol|cytoskeleton|actin filament|plasma membrane|cell-cell junction|focal adhesion|positive regulation of gene expression|membrane|positive regulation of cell migration|ubiquitin protein ligase binding|cell junction assembly|maintenance of blood-brain barrier|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|apical junction complex|ephrin receptor signaling pathway|regulation of stress fiber assembly|regulation of focal adhesion assembly|membrane organization|extracellular exosome|platelet aggregation|blood microparticle|positive regulation of wound healing|dense body|structural constituent of postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|tight junction assembly|regulation of transepithelial transport|protein localization to bicellular tight junction "hsa04015,hsa04145,hsa04210,hsa04390,hsa04510,hsa04520,hsa04530,hsa04611,hsa04670,hsa04714,hsa04810,hsa04919,hsa04921,hsa04971,hsa05014,hsa05100,hsa05110,hsa05130,hsa05131,hsa05132,hsa05135,hsa05164,hsa05205,hsa05225,hsa05410,hsa05412,hsa05414,hsa05416,hsa05418" Rap1 signaling pathway|Phagosome|Apoptosis|Hippo signaling pathway|Focal adhesion|Adherens junction|Tight junction|Platelet activation|Leukocyte transendothelial migration|Thermogenesis|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Gastric acid secretion|Amyotrophic lateral sclerosis|Bacterial invasion of epithelial cells|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Influenza A|Proteoglycans in cancer|Hepatocellular carcinoma|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis|Fluid shear stress and atherosclerosis ACTG2 5.941278051 2.029911937 9.852644165 4.853729853 2.279093814 0.221443742 1 0.068492924 0.34676658 72 "actin gamma 2, smooth muscle" "GO:0005524,GO:0005615,GO:0005737,GO:0005829,GO:0005869,GO:0006936,GO:0010628,GO:0030027,GO:0030175,GO:0032982,GO:0044297,GO:0070062,GO:0071944,GO:0072562,GO:0090131" ATP binding|extracellular space|cytoplasm|cytosol|dynactin complex|muscle contraction|positive regulation of gene expression|lamellipodium|filopodium|myosin filament|cell body|extracellular exosome|cell periphery|blood microparticle|mesenchyme migration hsa04270 Vascular smooth muscle contraction ACTL10 29.614594 37.55337083 21.67581716 0.577200307 -0.792856028 0.430918033 1 1.20148184 0.723368668 170487 actin like 10 GO:0005869 dynactin complex ACTL6A 1619.04083 1499.089965 1738.991695 1.160031576 0.214164076 0.514959315 1 44.39977677 53.7237757 86 actin like 6A "GO:0000785,GO:0001825,GO:0003407,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006281,GO:0006310,GO:0006338,GO:0006357,GO:0007165,GO:0007399,GO:0016514,GO:0016579,GO:0021510,GO:0031011,GO:0031492,GO:0032991,GO:0035267,GO:0040008,GO:0043044,GO:0043967,GO:0043968,GO:0045893,GO:0071564" "chromatin|blastocyst formation|neural retina development|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|plasma membrane|DNA repair|DNA recombination|chromatin remodeling|regulation of transcription by RNA polymerase II|signal transduction|nervous system development|SWI/SNF complex|protein deubiquitination|spinal cord development|Ino80 complex|nucleosomal DNA binding|protein-containing complex|NuA4 histone acetyltransferase complex|regulation of growth|ATP-dependent chromatin remodeling|histone H4 acetylation|histone H2A acetylation|positive regulation of transcription, DNA-templated|npBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma ACTN1 11490.54683 11511.63059 11469.46307 0.996336964 -0.005294347 0.987884678 1 118.6212572 123.2777488 87 actinin alpha 1 "GO:0001725,GO:0001726,GO:0002576,GO:0003725,GO:0005178,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005903,GO:0005911,GO:0005916,GO:0005925,GO:0007015,GO:0017166,GO:0030018,GO:0030168,GO:0030220,GO:0030374,GO:0031093,GO:0031143,GO:0036344,GO:0042803,GO:0042981,GO:0042995,GO:0044325,GO:0045893,GO:0048041,GO:0051015,GO:0051017,GO:0051271,GO:0051639,GO:0070062,GO:0070527,GO:0098978,GO:0099173,GO:0099186" "stress fiber|ruffle|platelet degranulation|double-stranded RNA binding|integrin binding|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|cytosol|actin filament|plasma membrane|brush border|cell-cell junction|fascia adherens|focal adhesion|actin filament organization|vinculin binding|Z disc|platelet activation|platelet formation|nuclear receptor coactivator activity|platelet alpha granule lumen|pseudopodium|platelet morphogenesis|protein homodimerization activity|regulation of apoptotic process|cell projection|ion channel binding|positive regulation of transcription, DNA-templated|focal adhesion assembly|actin filament binding|actin filament bundle assembly|negative regulation of cellular component movement|actin filament network formation|extracellular exosome|platelet aggregation|glutamatergic synapse|postsynapse organization|structural constituent of postsynapse" "hsa04510,hsa04520,hsa04530,hsa04670,hsa04810,hsa05131,hsa05146,hsa05203,hsa05322" Focal adhesion|Adherens junction|Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Amoebiasis|Viral carcinogenesis|Systemic lupus erythematosus ACTN2 8.567742628 13.19442759 3.941057666 0.298691068 -1.743273999 0.256867275 1 0.131830975 0.041072925 88 actinin alpha 2 "GO:0000165,GO:0002576,GO:0005178,GO:0005509,GO:0005515,GO:0005546,GO:0005576,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005925,GO:0007155,GO:0008092,GO:0008307,GO:0019904,GO:0030018,GO:0030035,GO:0030049,GO:0030175,GO:0030274,GO:0030374,GO:0030864,GO:0031093,GO:0031143,GO:0031432,GO:0042391,GO:0042802,GO:0042981,GO:0043197,GO:0043267,GO:0043268,GO:0044325,GO:0045214,GO:0045893,GO:0048041,GO:0051015,GO:0051373,GO:0051695,GO:0055013,GO:0070062,GO:0070080,GO:0072659,GO:0086097,GO:0098839,GO:0098978,GO:0099092,GO:1901017,GO:1901018,GO:2000009,GO:2000310,GO:2001137,GO:2001259" "MAPK cascade|platelet degranulation|integrin binding|calcium ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|cytosol|cytoskeleton|actin filament|plasma membrane|focal adhesion|cell adhesion|cytoskeletal protein binding|structural constituent of muscle|protein domain specific binding|Z disc|microspike assembly|muscle filament sliding|filopodium|LIM domain binding|nuclear receptor coactivator activity|cortical actin cytoskeleton|platelet alpha granule lumen|pseudopodium|titin binding|regulation of membrane potential|identical protein binding|regulation of apoptotic process|dendritic spine|negative regulation of potassium ion transport|positive regulation of potassium ion transport|ion channel binding|sarcomere organization|positive regulation of transcription, DNA-templated|focal adhesion assembly|actin filament binding|FATZ binding|actin filament uncapping|cardiac muscle cell development|extracellular exosome|titin Z domain binding|protein localization to plasma membrane|phospholipase C-activating angiotensin-activated signaling pathway|postsynaptic density membrane|glutamatergic synapse|postsynaptic density, intracellular component|negative regulation of potassium ion transmembrane transporter activity|positive regulation of potassium ion transmembrane transporter activity|negative regulation of protein localization to cell surface|regulation of NMDA receptor activity|positive regulation of endocytic recycling|positive regulation of cation channel activity" hsa05412 Arrhythmogenic right ventricular cardiomyopathy ACTN3 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.015700653 0.047693644 89 actinin alpha 3 "GO:0003779,GO:0005178,GO:0005509,GO:0005515,GO:0005829,GO:0005884,GO:0005925,GO:0008307,GO:0014728,GO:0014732,GO:0014883,GO:0014894,GO:0030049,GO:0031143,GO:0042802,GO:0042981,GO:0044325,GO:0045820,GO:0048041,GO:0048633,GO:0070062,GO:0070885,GO:0090324,GO:0120163,GO:1903715,GO:1904025" actin binding|integrin binding|calcium ion binding|protein binding|cytosol|actin filament|focal adhesion|structural constituent of muscle|regulation of the force of skeletal muscle contraction|skeletal muscle atrophy|transition between fast and slow fiber|response to denervation involved in regulation of muscle adaptation|muscle filament sliding|pseudopodium|identical protein binding|regulation of apoptotic process|ion channel binding|negative regulation of glycolytic process|focal adhesion assembly|positive regulation of skeletal muscle tissue growth|extracellular exosome|negative regulation of calcineurin-NFAT signaling cascade|negative regulation of oxidative phosphorylation|negative regulation of cold-induced thermogenesis|regulation of aerobic respiration|positive regulation of glucose catabolic process to lactate via pyruvate hsa05412 Arrhythmogenic right ventricular cardiomyopathy ACTN4 10308.04396 10488.55498 10127.53294 0.96557943 -0.050533152 0.881141356 1 144.5464784 145.5832635 81 actinin alpha 4 "GO:0000977,GO:0001666,GO:0001725,GO:0001882,GO:0002576,GO:0003713,GO:0003723,GO:0003779,GO:0005178,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0015031,GO:0015629,GO:0016604,GO:0030050,GO:0030335,GO:0030374,GO:0031093,GO:0031143,GO:0031490,GO:0032417,GO:0032991,GO:0033209,GO:0035257,GO:0035357,GO:0042803,GO:0042974,GO:0042981,GO:0043005,GO:0044325,GO:0045893,GO:0047485,GO:0048384,GO:0048471,GO:0051015,GO:0051272,GO:0070062,GO:1900025,GO:1901224,GO:1903506,GO:1990904" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|response to hypoxia|stress fiber|nucleoside binding|platelet degranulation|transcription coactivator activity|RNA binding|actin binding|integrin binding|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|cytosol|focal adhesion|protein transport|actin cytoskeleton|nuclear body|vesicle transport along actin filament|positive regulation of cell migration|nuclear receptor coactivator activity|platelet alpha granule lumen|pseudopodium|chromatin DNA binding|positive regulation of sodium:proton antiporter activity|protein-containing complex|tumor necrosis factor-mediated signaling pathway|nuclear hormone receptor binding|peroxisome proliferator activated receptor signaling pathway|protein homodimerization activity|retinoic acid receptor binding|regulation of apoptotic process|neuron projection|ion channel binding|positive regulation of transcription, DNA-templated|protein N-terminus binding|retinoic acid receptor signaling pathway|perinuclear region of cytoplasm|actin filament binding|positive regulation of cellular component movement|extracellular exosome|negative regulation of substrate adhesion-dependent cell spreading|positive regulation of NIK/NF-kappaB signaling|regulation of nucleic acid-templated transcription|ribonucleoprotein complex" "hsa04510,hsa04520,hsa04530,hsa04670,hsa04810,hsa05131,hsa05146,hsa05203,hsa05322" Focal adhesion|Adherens junction|Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Amoebiasis|Viral carcinogenesis|Systemic lupus erythematosus ACTR10 1195.323437 1057.584119 1333.062756 1.260479173 0.33397228 0.329348069 1 33.60282603 44.18017252 55860 actin related protein 10 "GO:0005515,GO:0005576,GO:0005829,GO:0005869,GO:0006888,GO:0007018,GO:0019886,GO:0035578,GO:0043312,GO:0098958,GO:1904115,GO:1904813" protein binding|extracellular region|cytosol|dynactin complex|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|antigen processing and presentation of exogenous peptide antigen via MHC class II|azurophil granule lumen|neutrophil degranulation|retrograde axonal transport of mitochondrion|axon cytoplasm|ficolin-1-rich granule lumen "hsa05014,hsa05016,hsa05022,hsa05132" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection ACTR1A 9813.208386 9495.92804 10130.48873 1.066824505 0.093322869 0.781300297 1 169.9417864 189.1076474 10121 actin related protein 1A "GO:0000086,GO:0002177,GO:0005515,GO:0005524,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005869,GO:0005875,GO:0006888,GO:0007283,GO:0010389,GO:0015630,GO:0016192,GO:0019886,GO:0030137,GO:0070062,GO:0097711,GO:0099738" G2/M transition of mitotic cell cycle|manchette|protein binding|ATP binding|cytoplasm|centrosome|centriole|cytosol|dynactin complex|microtubule associated complex|endoplasmic reticulum to Golgi vesicle-mediated transport|spermatogenesis|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPI-coated vesicle|extracellular exosome|ciliary basal body-plasma membrane docking|cell cortex region "hsa05014,hsa05016,hsa05022,hsa05132" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection ACTR1B 877.6244058 825.1592023 930.0896092 1.127163833 0.172697226 0.633667729 1 17.21936655 20.24511023 10120 actin related protein 1B "GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005813,GO:0005829,GO:0005869,GO:0015630,GO:0016020,GO:0019886,GO:0034774,GO:0043312,GO:0070062,GO:1904813" protein binding|ATP binding|extracellular region|cytoplasm|centrosome|cytosol|dynactin complex|microtubule cytoskeleton|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|secretory granule lumen|neutrophil degranulation|extracellular exosome|ficolin-1-rich granule lumen "hsa05014,hsa05016,hsa05022,hsa05132" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection ACTR2 6912.853447 6987.971842 6837.735051 0.978500659 -0.031355273 0.924081988 1 93.18486617 95.10918013 10097 actin related protein 2 "GO:0005200,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005885,GO:0005925,GO:0007163,GO:0008306,GO:0008356,GO:0010592,GO:0014069,GO:0015629,GO:0016020,GO:0016344,GO:0016482,GO:0030027,GO:0030478,GO:0033206,GO:0034314,GO:0035578,GO:0035861,GO:0035902,GO:0035984,GO:0038096,GO:0043312,GO:0045471,GO:0045944,GO:0048013,GO:0051015,GO:0051653,GO:0060271,GO:0061003,GO:0061024,GO:0061825,GO:0070062,GO:0071346,GO:0071437,GO:1904813,GO:1905168,GO:2001032" structural constituent of cytoskeleton|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|cytosol|Arp2/3 protein complex|focal adhesion|establishment or maintenance of cell polarity|associative learning|asymmetric cell division|positive regulation of lamellipodium assembly|postsynaptic density|actin cytoskeleton|membrane|meiotic chromosome movement towards spindle pole|cytosolic transport|lamellipodium|actin cap|meiotic cytokinesis|Arp2/3 complex-mediated actin nucleation|azurophil granule lumen|site of double-strand break|response to immobilization stress|cellular response to trichostatin A|Fc-gamma receptor signaling pathway involved in phagocytosis|neutrophil degranulation|response to ethanol|positive regulation of transcription by RNA polymerase II|ephrin receptor signaling pathway|actin filament binding|spindle localization|cilium assembly|positive regulation of dendritic spine morphogenesis|membrane organization|podosome core|extracellular exosome|cellular response to interferon-gamma|invadopodium|ficolin-1-rich granule lumen|positive regulation of double-strand break repair via homologous recombination|regulation of double-strand break repair via nonhomologous end joining "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ACTR3 4747.192271 5031.136735 4463.247807 0.887125125 -0.17279049 0.589823331 1 44.48486852 41.16357832 10096 actin related protein 3 "GO:0005200,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005885,GO:0005903,GO:0005911,GO:0005925,GO:0007163,GO:0008356,GO:0010592,GO:0015629,GO:0016020,GO:0016344,GO:0030027,GO:0033206,GO:0034314,GO:0035861,GO:0038096,GO:0045944,GO:0048013,GO:0051015,GO:0051653,GO:0060271,GO:0061024,GO:0070062,GO:0070358,GO:0071346" structural constituent of cytoskeleton|protein binding|ATP binding|nucleus|cytoplasm|cytosol|Arp2/3 protein complex|brush border|cell-cell junction|focal adhesion|establishment or maintenance of cell polarity|asymmetric cell division|positive regulation of lamellipodium assembly|actin cytoskeleton|membrane|meiotic chromosome movement towards spindle pole|lamellipodium|meiotic cytokinesis|Arp2/3 complex-mediated actin nucleation|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of transcription by RNA polymerase II|ephrin receptor signaling pathway|actin filament binding|spindle localization|cilium assembly|membrane organization|extracellular exosome|actin polymerization-dependent cell motility|cellular response to interferon-gamma "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ACTR3B 121.5950402 128.899408 114.2906723 0.886665611 -0.173537973 0.794823904 1 0.99003644 0.915644675 57180 actin related protein 3B "GO:0003674,GO:0005524,GO:0005737,GO:0005856,GO:0008150,GO:0042995,GO:0051015,GO:0070062" molecular_function|ATP binding|cytoplasm|cytoskeleton|biological_process|cell projection|actin filament binding|extracellular exosome "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ACTR3C 31.97383461 30.44867905 33.49899016 1.100178767 0.137737964 0.919573719 1 0.073715018 0.084593144 653857 actin related protein 3C "GO:0003674,GO:0005524,GO:0008150,GO:0051015,GO:0070062" molecular_function|ATP binding|biological_process|actin filament binding|extracellular exosome "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ACTR5 304.6421753 350.1598091 259.1245416 0.740017943 -0.434367844 0.356771793 1 6.962842183 5.374582472 79913 actin related protein 5 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006302,GO:0006310,GO:0006355,GO:0016579,GO:0031011,GO:0043044,GO:0070914" "protein binding|nucleus|nucleoplasm|cytoplasm|double-strand break repair|DNA recombination|regulation of transcription, DNA-templated|protein deubiquitination|Ino80 complex|ATP-dependent chromatin remodeling|UV-damage excision repair" ACTR6 400.0967791 308.5466144 491.6469439 1.593428419 0.672134211 0.121597426 1 8.996429206 14.95266678 64431 actin related protein 6 "GO:0000812,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0031491,GO:0043486" Swr1 complex|protein binding|nucleus|cytoplasm|cytoskeleton|nucleosome binding|histone exchange ACTR8 1176.387408 1143.855376 1208.919439 1.056881372 0.079813452 0.818034323 1 4.890860239 5.391721179 93973 actin related protein 8 "GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0006302,GO:0006310,GO:0006355,GO:0007049,GO:0016579,GO:0031011,GO:0043044,GO:0051301" "protein binding|ATP binding|nucleus|nucleoplasm|centrosome|double-strand break repair|DNA recombination|regulation of transcription, DNA-templated|cell cycle|protein deubiquitination|Ino80 complex|ATP-dependent chromatin remodeling|cell division" ACTRT3 98.69642616 112.6601125 84.73273982 0.752109491 -0.410985393 0.551410255 1 3.414624331 2.678797773 84517 actin related protein T3 "GO:0005634,GO:0005737,GO:0005856" nucleus|cytoplasm|cytoskeleton ACVR1 605.8710599 635.3624362 576.3796837 0.907166762 -0.140560314 0.72128187 1 8.223579343 7.781511185 90 activin A receptor type 1 "GO:0000082,GO:0001525,GO:0001569,GO:0001701,GO:0001702,GO:0001707,GO:0001755,GO:0002526,GO:0003143,GO:0003148,GO:0003181,GO:0003183,GO:0003203,GO:0003274,GO:0003289,GO:0004672,GO:0004674,GO:0004675,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0006468,GO:0007179,GO:0007281,GO:0007368,GO:0007507,GO:0009953,GO:0009968,GO:0010862,GO:0016361,GO:0017046,GO:0018107,GO:0030278,GO:0030335,GO:0030501,GO:0030509,GO:0032924,GO:0032926,GO:0042803,GO:0043235,GO:0045177,GO:0045296,GO:0045669,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0048179,GO:0048185,GO:0050431,GO:0050731,GO:0051145,GO:0060037,GO:0060389,GO:0060412,GO:0060923,GO:0061312,GO:0061445,GO:0070724,GO:0071363,GO:0071773,GO:1905007,GO:1990782,GO:2000017,GO:2001237" "G1/S transition of mitotic cell cycle|angiogenesis|branching involved in blood vessel morphogenesis|in utero embryonic development|gastrulation with mouth forming second|mesoderm formation|neural crest cell migration|acute inflammatory response|embryonic heart tube morphogenesis|outflow tract septum morphogenesis|atrioventricular valve morphogenesis|mitral valve morphogenesis|endocardial cushion morphogenesis|endocardial cushion fusion|atrial septum primum morphogenesis|protein kinase activity|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta receptor activity, type I|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|protein phosphorylation|transforming growth factor beta receptor signaling pathway|germ cell development|determination of left/right symmetry|heart development|dorsal/ventral pattern formation|negative regulation of signal transduction|positive regulation of pathway-restricted SMAD protein phosphorylation|activin receptor activity, type I|peptide hormone binding|peptidyl-threonine phosphorylation|regulation of ossification|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|activin receptor signaling pathway|negative regulation of activin receptor signaling pathway|protein homodimerization activity|receptor complex|apical part of cell|cadherin binding|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|activin receptor complex|activin binding|transforming growth factor beta binding|positive regulation of peptidyl-tyrosine phosphorylation|smooth muscle cell differentiation|pharyngeal system development|pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|cardiac muscle cell fate commitment|BMP signaling pathway involved in heart development|endocardial cushion cell fate commitment|BMP receptor complex|cellular response to growth factor stimulus|cellular response to BMP stimulus|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|protein tyrosine kinase binding|positive regulation of determination of dorsal identity|negative regulation of extrinsic apoptotic signaling pathway" "hsa04060,hsa04350,hsa04550,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis ACVR1B 612.192885 730.7682972 493.6174727 0.675477404 -0.566020584 0.146039775 1 6.821016635 4.805912554 91 activin A receptor type 1B "GO:0000082,GO:0001701,GO:0001942,GO:0004674,GO:0004675,GO:0005515,GO:0005524,GO:0005829,GO:0005886,GO:0005887,GO:0006355,GO:0006468,GO:0007165,GO:0007178,GO:0007399,GO:0007417,GO:0009986,GO:0010629,GO:0010862,GO:0016361,GO:0017002,GO:0018107,GO:0019838,GO:0030308,GO:0031625,GO:0032924,GO:0032927,GO:0034711,GO:0038092,GO:0043235,GO:0045648,GO:0045944,GO:0046332,GO:0046545,GO:0046777,GO:0046872,GO:0048179,GO:0048185,GO:0071363,GO:0097191,GO:1901165" "G1/S transition of mitotic cell cycle|in utero embryonic development|hair follicle development|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|protein phosphorylation|signal transduction|transmembrane receptor protein serine/threonine kinase signaling pathway|nervous system development|central nervous system development|cell surface|negative regulation of gene expression|positive regulation of pathway-restricted SMAD protein phosphorylation|activin receptor activity, type I|activin-activated receptor activity|peptidyl-threonine phosphorylation|growth factor binding|negative regulation of cell growth|ubiquitin protein ligase binding|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|inhibin binding|nodal signaling pathway|receptor complex|positive regulation of erythrocyte differentiation|positive regulation of transcription by RNA polymerase II|SMAD binding|development of primary female sexual characteristics|protein autophosphorylation|metal ion binding|activin receptor complex|activin binding|cellular response to growth factor stimulus|extrinsic apoptotic signaling pathway|positive regulation of trophoblast cell migration" "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells ACVR1C 16.94249017 13.19442759 20.69055275 1.568128106 0.649043423 0.603233323 1 0.073807291 0.120724866 130399 activin A receptor type 1C "GO:0001834,GO:0002021,GO:0004674,GO:0005524,GO:0005886,GO:0006468,GO:0007399,GO:0009749,GO:0016361,GO:0019838,GO:0019915,GO:0030154,GO:0030262,GO:0032868,GO:0032924,GO:0038092,GO:0038100,GO:0043065,GO:0043235,GO:0043280,GO:0046676,GO:0046872,GO:0048179,GO:0071363,GO:1901164,GO:1901383" "trophectodermal cell proliferation|response to dietary excess|protein serine/threonine kinase activity|ATP binding|plasma membrane|protein phosphorylation|nervous system development|response to glucose|activin receptor activity, type I|growth factor binding|lipid storage|cell differentiation|apoptotic nuclear changes|response to insulin|activin receptor signaling pathway|nodal signaling pathway|nodal binding|positive regulation of apoptotic process|receptor complex|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of insulin secretion|metal ion binding|activin receptor complex|cellular response to growth factor stimulus|negative regulation of trophoblast cell migration|negative regulation of chorionic trophoblast cell proliferation" "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells ACVR2A 94.48814452 94.39090506 94.58538399 1.002060357 0.002969408 1 1 0.88463478 0.924642434 92 activin A receptor type 2A "GO:0001702,GO:0001934,GO:0004674,GO:0004675,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0005887,GO:0006468,GO:0007178,GO:0007283,GO:0007368,GO:0007498,GO:0009952,GO:0009986,GO:0010862,GO:0015026,GO:0017002,GO:0019838,GO:0030165,GO:0030501,GO:0030509,GO:0032924,GO:0032927,GO:0034673,GO:0034711,GO:0042713,GO:0043084,GO:0043235,GO:0043621,GO:0045648,GO:0045669,GO:0045944,GO:0046872,GO:0048179,GO:0048185,GO:0048706,GO:0050999,GO:0060011,GO:0071363,GO:0071773,GO:0098821" gastrulation with mouth forming second|positive regulation of protein phosphorylation|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|spermatogenesis|determination of left/right symmetry|mesoderm development|anterior/posterior pattern specification|cell surface|positive regulation of pathway-restricted SMAD protein phosphorylation|coreceptor activity|activin-activated receptor activity|growth factor binding|PDZ domain binding|positive regulation of bone mineralization|BMP signaling pathway|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|inhibin-betaglycan-ActRII complex|inhibin binding|sperm ejaculation|penile erection|receptor complex|protein self-association|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|activin receptor complex|activin binding|embryonic skeletal system development|regulation of nitric-oxide synthase activity|Sertoli cell proliferation|cellular response to growth factor stimulus|cellular response to BMP stimulus|BMP receptor activity "hsa04060,hsa04350,hsa04550,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis ACVR2B 761.3768126 657.6914675 865.0621577 1.315300867 0.395392845 0.286850214 1 1.842353575 2.527633005 93 activin A receptor type 2B "GO:0000122,GO:0001946,GO:0001974,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0005887,GO:0006355,GO:0006468,GO:0007165,GO:0007178,GO:0009952,GO:0016362,GO:0017002,GO:0019838,GO:0030501,GO:0030509,GO:0032924,GO:0032927,GO:0032991,GO:0043235,GO:0045669,GO:0046872,GO:0048179,GO:0048185,GO:0060836,GO:0060840,GO:0060841,GO:0061298,GO:0071363,GO:0120163" "negative regulation of transcription by RNA polymerase II|lymphangiogenesis|blood vessel remodeling|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|protein phosphorylation|signal transduction|transmembrane receptor protein serine/threonine kinase signaling pathway|anterior/posterior pattern specification|activin receptor activity, type II|activin-activated receptor activity|growth factor binding|positive regulation of bone mineralization|BMP signaling pathway|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|protein-containing complex|receptor complex|positive regulation of osteoblast differentiation|metal ion binding|activin receptor complex|activin binding|lymphatic endothelial cell differentiation|artery development|venous blood vessel development|retina vasculature development in camera-type eye|cellular response to growth factor stimulus|negative regulation of cold-induced thermogenesis" "hsa04060,hsa04350,hsa04550,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis ACY3 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.036822306 0.111854578 91703 aminoacylase 3 "GO:0003674,GO:0004046,GO:0005515,GO:0005829,GO:0006805,GO:0008150,GO:0016032,GO:0016324,GO:0016788,GO:0016811,GO:0042802,GO:0046872,GO:0070062" "molecular_function|aminoacylase activity|protein binding|cytosol|xenobiotic metabolic process|biological_process|viral process|apical plasma membrane|hydrolase activity, acting on ester bonds|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|identical protein binding|metal ion binding|extracellular exosome" ACYP1 157.8122911 112.6601125 202.9644698 1.801564594 0.84925038 0.145804476 1 6.626988684 12.45322964 97 acylphosphatase 1 "GO:0003998,GO:0006796" acylphosphatase activity|phosphate-containing compound metabolic process hsa00620 Pyruvate metabolism ACYP2 47.4087366 41.6131947 53.20427849 1.278543473 0.354501216 0.695763232 1 0.330131815 0.440269712 98 acylphosphatase 2 "GO:0003998,GO:0005515,GO:0006796,GO:0042802" acylphosphatase activity|protein binding|phosphate-containing compound metabolic process|identical protein binding hsa00620 Pyruvate metabolism ADA 112.9058097 141.0788796 84.73273982 0.600605421 -0.735510599 0.259482646 1 4.776168152 2.992159812 100 adenosine deaminase "GO:0001666,GO:0001821,GO:0001829,GO:0001883,GO:0001889,GO:0001890,GO:0002314,GO:0002636,GO:0002686,GO:0002906,GO:0004000,GO:0005515,GO:0005615,GO:0005764,GO:0005829,GO:0005886,GO:0006154,GO:0006157,GO:0007155,GO:0007568,GO:0008270,GO:0009168,GO:0009897,GO:0009986,GO:0010460,GO:0016020,GO:0030054,GO:0030890,GO:0032261,GO:0032839,GO:0033089,GO:0033197,GO:0033632,GO:0042110,GO:0042323,GO:0042493,GO:0042542,GO:0043025,GO:0043101,GO:0043103,GO:0043278,GO:0045987,GO:0046059,GO:0046061,GO:0046103,GO:0046111,GO:0046638,GO:0048286,GO:0048541,GO:0048566,GO:0050728,GO:0050850,GO:0050862,GO:0060169,GO:0060205,GO:0060407,GO:0070244,GO:0070256" "response to hypoxia|histamine secretion|trophectodermal cell differentiation|purine nucleoside binding|liver development|placenta development|germinal center B cell differentiation|positive regulation of germinal center formation|negative regulation of leukocyte migration|negative regulation of mature B cell apoptotic process|adenosine deaminase activity|protein binding|extracellular space|lysosome|cytosol|plasma membrane|adenosine catabolic process|deoxyadenosine catabolic process|cell adhesion|aging|zinc ion binding|purine ribonucleoside monophosphate biosynthetic process|external side of plasma membrane|cell surface|positive regulation of heart rate|membrane|cell junction|positive regulation of B cell proliferation|purine nucleotide salvage|dendrite cytoplasm|positive regulation of T cell differentiation in thymus|response to vitamin E|regulation of cell-cell adhesion mediated by integrin|T cell activation|negative regulation of circadian sleep/wake cycle, non-REM sleep|response to drug|response to hydrogen peroxide|neuronal cell body|purine-containing compound salvage|hypoxanthine salvage|response to morphine|positive regulation of smooth muscle contraction|dAMP catabolic process|dATP catabolic process|inosine biosynthetic process|xanthine biosynthetic process|positive regulation of alpha-beta T cell differentiation|lung alveolus development|Peyer's patch development|embryonic digestive tract development|negative regulation of inflammatory response|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|negative regulation of adenosine receptor signaling pathway|cytoplasmic vesicle lumen|negative regulation of penile erection|negative regulation of thymocyte apoptotic process|negative regulation of mucus secretion" "hsa00230,hsa05340" Purine metabolism|Primary immunodeficiency ADAL 146.0282123 182.6920743 109.3643502 0.598626682 -0.740271511 0.216138358 1 2.355577664 1.470853531 161823 adenosine deaminase like "GO:0004000,GO:0005829,GO:0006154,GO:0009117,GO:0017144,GO:0043101,GO:0046103,GO:0046872" adenosine deaminase activity|cytosol|adenosine catabolic process|nucleotide metabolic process|drug metabolic process|purine-containing compound salvage|inosine biosynthetic process|metal ion binding ADAM10 2588.324026 3067.196936 2109.451116 0.687745573 -0.540053146 0.090760833 1 13.71074178 9.835686672 102 ADAM metallopeptidase domain 10 "GO:0000139,GO:0001701,GO:0004175,GO:0004222,GO:0005102,GO:0005178,GO:0005515,GO:0005634,GO:0005737,GO:0005788,GO:0005794,GO:0005798,GO:0005802,GO:0005886,GO:0005912,GO:0005925,GO:0006468,GO:0006509,GO:0007162,GO:0007219,GO:0007229,GO:0007267,GO:0007283,GO:0008021,GO:0008237,GO:0008284,GO:0008593,GO:0009986,GO:0010629,GO:0010820,GO:0014069,GO:0016020,GO:0016021,GO:0016485,GO:0017124,GO:0019901,GO:0022617,GO:0030136,GO:0030307,GO:0030335,GO:0030424,GO:0034205,GO:0034332,GO:0034612,GO:0035333,GO:0035579,GO:0042117,GO:0042803,GO:0042987,GO:0043025,GO:0043065,GO:0043066,GO:0043197,GO:0043231,GO:0043312,GO:0043687,GO:0044267,GO:0045211,GO:0046872,GO:0046930,GO:0046931,GO:0051089,GO:0061001,GO:0070062,GO:0070821,GO:0071157,GO:0090102,GO:0097038,GO:0097060,GO:0097197,GO:0097327,GO:0098696,GO:0098978,GO:0099173,GO:1901342,GO:1901998,GO:1902945" "Golgi membrane|in utero embryonic development|endopeptidase activity|metalloendopeptidase activity|signaling receptor binding|integrin binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum lumen|Golgi apparatus|Golgi-associated vesicle|trans-Golgi network|plasma membrane|adherens junction|focal adhesion|protein phosphorylation|membrane protein ectodomain proteolysis|negative regulation of cell adhesion|Notch signaling pathway|integrin-mediated signaling pathway|cell-cell signaling|spermatogenesis|synaptic vesicle|metallopeptidase activity|positive regulation of cell population proliferation|regulation of Notch signaling pathway|cell surface|negative regulation of gene expression|positive regulation of T cell chemotaxis|postsynaptic density|membrane|integral component of membrane|protein processing|SH3 domain binding|protein kinase binding|extracellular matrix disassembly|clathrin-coated vesicle|positive regulation of cell growth|positive regulation of cell migration|axon|amyloid-beta formation|adherens junction organization|response to tumor necrosis factor|Notch receptor processing, ligand-dependent|specific granule membrane|monocyte activation|protein homodimerization activity|amyloid precursor protein catabolic process|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|dendritic spine|intracellular membrane-bounded organelle|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|postsynaptic membrane|metal ion binding|pore complex|pore complex assembly|constitutive protein ectodomain proteolysis|regulation of dendritic spine morphogenesis|extracellular exosome|tertiary granule membrane|negative regulation of cell cycle arrest|cochlea development|perinuclear endoplasmic reticulum|synaptic membrane|tetraspanin-enriched microdomain|response to antineoplastic agent|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|glutamatergic synapse|postsynapse organization|regulation of vasculature development|toxin transport|metalloendopeptidase activity involved in amyloid precursor protein catabolic process" "hsa05010,hsa05120" Alzheimer disease|Epithelial cell signaling in Helicobacter pylori infection ADAM11 65.58886937 72.06187375 59.11586499 0.820348707 -0.285690805 0.726397113 1 0.714362828 0.611270273 4185 ADAM metallopeptidase domain 11 "GO:0004222,GO:0005178,GO:0005886,GO:0006508,GO:0007229,GO:0008237,GO:0016021,GO:0062023" metalloendopeptidase activity|integrin binding|plasma membrane|proteolysis|integrin-mediated signaling pathway|metallopeptidase activity|integral component of membrane|collagen-containing extracellular matrix ADAM12 492.7574094 480.074173 505.4406457 1.052838653 0.074284361 0.86073618 1 2.217829359 2.435599515 8038 ADAM metallopeptidase domain 12 "GO:0004222,GO:0005515,GO:0005576,GO:0005654,GO:0005886,GO:0006508,GO:0007155,GO:0007520,GO:0008237,GO:0016021,GO:0017124,GO:0030198,GO:0045766,GO:0046872" metalloendopeptidase activity|protein binding|extracellular region|nucleoplasm|plasma membrane|proteolysis|cell adhesion|myoblast fusion|metallopeptidase activity|integral component of membrane|SH3 domain binding|extracellular matrix organization|positive regulation of angiogenesis|metal ion binding ADAM15 3273.889911 3055.017465 3492.762357 1.143287198 0.193187859 0.5437967 1 47.79915265 57.00218037 8751 ADAM metallopeptidase domain 15 "GO:0001525,GO:0001669,GO:0001953,GO:0002418,GO:0004222,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005912,GO:0006508,GO:0006915,GO:0007160,GO:0007229,GO:0008237,GO:0008584,GO:0009986,GO:0016021,GO:0017124,GO:0022617,GO:0030198,GO:0030308,GO:0030336,GO:0030574,GO:0031514,GO:0042246,GO:0045087,GO:0046872,GO:0060317,GO:0070062,GO:1900121,GO:1904628,GO:1990910" angiogenesis|acrosomal vesicle|negative regulation of cell-matrix adhesion|immune response to tumor cell|metalloendopeptidase activity|integrin binding|protein binding|extracellular space|plasma membrane|adherens junction|proteolysis|apoptotic process|cell-matrix adhesion|integrin-mediated signaling pathway|metallopeptidase activity|male gonad development|cell surface|integral component of membrane|SH3 domain binding|extracellular matrix disassembly|extracellular matrix organization|negative regulation of cell growth|negative regulation of cell migration|collagen catabolic process|motile cilium|tissue regeneration|innate immune response|metal ion binding|cardiac epithelial to mesenchymal transition|extracellular exosome|negative regulation of receptor binding|cellular response to phorbol 13-acetate 12-myristate|response to hypobaric hypoxia ADAM17 913.3960374 1148.930156 677.8619186 0.589994017 -0.761227769 0.034071046 0.828970386 8.722719117 5.368036071 6868 ADAM metallopeptidase domain 17 "GO:0001666,GO:0001934,GO:0002446,GO:0002467,GO:0002690,GO:0004175,GO:0004222,GO:0005112,GO:0005138,GO:0005178,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0006508,GO:0006509,GO:0007155,GO:0007173,GO:0007219,GO:0007220,GO:0008233,GO:0008237,GO:0008284,GO:0009986,GO:0010820,GO:0015629,GO:0016020,GO:0016324,GO:0016485,GO:0017124,GO:0030165,GO:0030183,GO:0030307,GO:0030335,GO:0030511,GO:0030512,GO:0031293,GO:0032496,GO:0032587,GO:0032722,GO:0033025,GO:0033077,GO:0033209,GO:0033627,GO:0035313,GO:0035624,GO:0042493,GO:0042987,GO:0043536,GO:0045121,GO:0045737,GO:0045741,GO:0046872,GO:0048536,GO:0048870,GO:0050830,GO:0051272,GO:0071403,GO:0120163,GO:1900087,GO:1902945,GO:1903265,GO:1905564" "response to hypoxia|positive regulation of protein phosphorylation|neutrophil mediated immunity|germinal center formation|positive regulation of leukocyte chemotaxis|endopeptidase activity|metalloendopeptidase activity|Notch binding|interleukin-6 receptor binding|integrin binding|protein binding|cytoplasm|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|proteolysis|membrane protein ectodomain proteolysis|cell adhesion|epidermal growth factor receptor signaling pathway|Notch signaling pathway|Notch receptor processing|peptidase activity|metallopeptidase activity|positive regulation of cell population proliferation|cell surface|positive regulation of T cell chemotaxis|actin cytoskeleton|membrane|apical plasma membrane|protein processing|SH3 domain binding|PDZ domain binding|B cell differentiation|positive regulation of cell growth|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|membrane protein intracellular domain proteolysis|response to lipopolysaccharide|ruffle membrane|positive regulation of chemokine production|regulation of mast cell apoptotic process|T cell differentiation in thymus|tumor necrosis factor-mediated signaling pathway|cell adhesion mediated by integrin|wound healing, spreading of epidermal cells|receptor transactivation|response to drug|amyloid precursor protein catabolic process|positive regulation of blood vessel endothelial cell migration|membrane raft|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of epidermal growth factor-activated receptor activity|metal ion binding|spleen development|cell motility|defense response to Gram-positive bacterium|positive regulation of cellular component movement|cellular response to high density lipoprotein particle stimulus|negative regulation of cold-induced thermogenesis|positive regulation of G1/S transition of mitotic cell cycle|metalloendopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of vascular endothelial cell proliferation" "hsa04330,hsa05010,hsa05120,hsa05171" Notch signaling pathway|Alzheimer disease|Epithelial cell signaling in Helicobacter pylori infection|Coronavirus disease - COVID-19 ADAM19 891.3423949 1022.06066 760.6241296 0.744206444 -0.426225212 0.236239324 1 7.974698324 6.19046994 8728 ADAM metallopeptidase domain 19 "GO:0001890,GO:0004222,GO:0005515,GO:0005634,GO:0005794,GO:0005886,GO:0006509,GO:0010628,GO:0016021,GO:0016485,GO:0017124,GO:0030198,GO:0042987,GO:0046872,GO:0062023,GO:1902945,GO:2000049" placenta development|metalloendopeptidase activity|protein binding|nucleus|Golgi apparatus|plasma membrane|membrane protein ectodomain proteolysis|positive regulation of gene expression|integral component of membrane|protein processing|SH3 domain binding|extracellular matrix organization|amyloid precursor protein catabolic process|metal ion binding|collagen-containing extracellular matrix|metalloendopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of cell-cell adhesion mediated by cadherin ADAM20 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.007649396 0.015490971 8748 ADAM metallopeptidase domain 20 "GO:0004222,GO:0005886,GO:0006508,GO:0007338,GO:0007339,GO:0008237,GO:0008584,GO:0009897,GO:0016021,GO:0046872,GO:1990913" metalloendopeptidase activity|plasma membrane|proteolysis|single fertilization|binding of sperm to zona pellucida|metallopeptidase activity|male gonad development|external side of plasma membrane|integral component of membrane|metal ion binding|sperm head plasma membrane ADAM22 159.4332023 189.7967661 129.0696386 0.680041295 -0.55630574 0.339095009 1 1.274027388 0.903711855 53616 ADAM metallopeptidase domain 22 "GO:0004222,GO:0005178,GO:0005515,GO:0005886,GO:0006508,GO:0007155,GO:0007162,GO:0007417,GO:0008344,GO:0016021,GO:0022011,GO:0030424,GO:0098978,GO:0099061,GO:0099645" metalloendopeptidase activity|integrin binding|protein binding|plasma membrane|proteolysis|cell adhesion|negative regulation of cell adhesion|central nervous system development|adult locomotory behavior|integral component of membrane|myelination in peripheral nervous system|axon|glutamatergic synapse|integral component of postsynaptic density membrane|neurotransmitter receptor localization to postsynaptic specialization membrane ADAM23 505.4619263 472.9694813 537.9543714 1.137397639 0.185736715 0.651053283 1 3.72828571 4.423208776 8745 ADAM metallopeptidase domain 23 "GO:0004222,GO:0005178,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006508,GO:0007155,GO:0007417,GO:0008237,GO:0098978,GO:0099056,GO:1990830" metalloendopeptidase activity|integrin binding|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|proteolysis|cell adhesion|central nervous system development|metallopeptidase activity|glutamatergic synapse|integral component of presynaptic membrane|cellular response to leukemia inhibitory factor ADAM28 11.09028677 17.25425146 4.926322083 0.285513521 -1.808369028 0.192461091 1 0.119658629 0.03563581 10863 ADAM metallopeptidase domain 28 "GO:0004175,GO:0004222,GO:0005515,GO:0005576,GO:0005739,GO:0005886,GO:0006508,GO:0007283,GO:0008237,GO:0016021,GO:0046872" endopeptidase activity|metalloendopeptidase activity|protein binding|extracellular region|mitochondrion|plasma membrane|proteolysis|spermatogenesis|metallopeptidase activity|integral component of membrane|metal ion binding ADAM32 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.052542357 0.070936509 203102 ADAM metallopeptidase domain 32 "GO:0004222,GO:0005515,GO:0006508,GO:0007155,GO:0007339,GO:0016021" metalloendopeptidase activity|protein binding|proteolysis|cell adhesion|binding of sperm to zona pellucida|integral component of membrane ADAM33 42.75236009 26.38885518 59.11586499 2.240183009 1.163616596 0.193686333 1 0.321583836 0.751438841 80332 ADAM metallopeptidase domain 33 "GO:0004222,GO:0006508,GO:0008270,GO:0016021" metalloendopeptidase activity|proteolysis|zinc ion binding|integral component of membrane ADAM8 556.2770266 848.5031896 264.0508636 0.311196077 -1.684104223 3.67E-05 0.007112457 11.33571438 3.679585828 101 ADAM metallopeptidase domain 8 "GO:0000902,GO:0001525,GO:0002102,GO:0002523,GO:0002675,GO:0002693,GO:0004222,GO:0004252,GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006508,GO:0006954,GO:0008237,GO:0008270,GO:0009986,GO:0010954,GO:0022407,GO:0022617,GO:0032010,GO:0032127,GO:0033089,GO:0035579,GO:0042581,GO:0043312,GO:0043406,GO:0043524,GO:0043621,GO:0045089,GO:0045780,GO:0045785,GO:0048247,GO:0050714,GO:0050839,GO:0051044,GO:0051092,GO:0051897,GO:0070245,GO:0070820,GO:0070821,GO:0071065,GO:0071133,GO:0071456,GO:0098609,GO:0101003,GO:2000309,GO:2000391,GO:2000415,GO:2000418" cell morphogenesis|angiogenesis|podosome|leukocyte migration involved in inflammatory response|positive regulation of acute inflammatory response|positive regulation of cellular extravasation|metalloendopeptidase activity|serine-type endopeptidase activity|calcium ion binding|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|proteolysis|inflammatory response|metallopeptidase activity|zinc ion binding|cell surface|positive regulation of protein processing|regulation of cell-cell adhesion|extracellular matrix disassembly|phagolysosome|dense core granule membrane|positive regulation of T cell differentiation in thymus|specific granule membrane|specific granule|neutrophil degranulation|positive regulation of MAP kinase activity|negative regulation of neuron apoptotic process|protein self-association|positive regulation of innate immune response|positive regulation of bone resorption|positive regulation of cell adhesion|lymphocyte chemotaxis|positive regulation of protein secretion|cell adhesion molecule binding|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling|positive regulation of thymocyte apoptotic process|tertiary granule|tertiary granule membrane|alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|alpha9-beta1 integrin-ADAM8 complex|cellular response to hypoxia|cell-cell adhesion|ficolin-1-rich granule membrane|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of neutrophil extravasation|positive regulation of fibronectin-dependent thymocyte migration|positive regulation of eosinophil migration ADAM9 3155.908583 4015.165811 2296.651355 0.57199415 -0.805927703 0.011696615 0.471833094 46.26939333 27.60586259 8754 ADAM metallopeptidase domain 9 "GO:0000186,GO:0004222,GO:0005080,GO:0005178,GO:0005515,GO:0005518,GO:0005615,GO:0005925,GO:0006509,GO:0007155,GO:0007160,GO:0007179,GO:0007229,GO:0008237,GO:0009986,GO:0010042,GO:0016021,GO:0016477,GO:0017124,GO:0030216,GO:0030335,GO:0031233,GO:0031293,GO:0033627,GO:0033630,GO:0033631,GO:0034241,GO:0034612,GO:0042117,GO:0042542,GO:0043236,GO:0046872,GO:0050714,GO:0051044,GO:0051384,GO:0051549,GO:0051592,GO:0070062,GO:0071222" activation of MAPKK activity|metalloendopeptidase activity|protein kinase C binding|integrin binding|protein binding|collagen binding|extracellular space|focal adhesion|membrane protein ectodomain proteolysis|cell adhesion|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|metallopeptidase activity|cell surface|response to manganese ion|integral component of membrane|cell migration|SH3 domain binding|keratinocyte differentiation|positive regulation of cell migration|intrinsic component of external side of plasma membrane|membrane protein intracellular domain proteolysis|cell adhesion mediated by integrin|positive regulation of cell adhesion mediated by integrin|cell-cell adhesion mediated by integrin|positive regulation of macrophage fusion|response to tumor necrosis factor|monocyte activation|response to hydrogen peroxide|laminin binding|metal ion binding|positive regulation of protein secretion|positive regulation of membrane protein ectodomain proteolysis|response to glucocorticoid|positive regulation of keratinocyte migration|response to calcium ion|extracellular exosome|cellular response to lipopolysaccharide ADAMTS1 11.5086901 12.17947162 10.83790858 0.889850473 -0.168365163 0.971008791 1 0.119013558 0.110466197 9510 ADAM metallopeptidase with thrombospondin type 1 motif 1 "GO:0001542,GO:0001822,GO:0004222,GO:0005515,GO:0005604,GO:0006508,GO:0007229,GO:0008201,GO:0008237,GO:0008270,GO:0008285,GO:0016525,GO:0030198,GO:0031012,GO:0031410,GO:0060347,GO:0062023,GO:1900087,GO:1904707,GO:1904754" ovulation from ovarian follicle|kidney development|metalloendopeptidase activity|protein binding|basement membrane|proteolysis|integrin-mediated signaling pathway|heparin binding|metallopeptidase activity|zinc ion binding|negative regulation of cell population proliferation|negative regulation of angiogenesis|extracellular matrix organization|extracellular matrix|cytoplasmic vesicle|heart trabecula formation|collagen-containing extracellular matrix|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration ADAMTS12 4787.388682 4545.987782 5028.789582 1.106203937 0.145617382 0.649794211 1 25.02317616 28.87310983 81792 ADAM metallopeptidase with thrombospondin type 1 motif 12 "GO:0004222,GO:0005515,GO:0007160,GO:0016477,GO:0030167,GO:0030198,GO:0031012,GO:0032331,GO:0046872,GO:0050727,GO:0051603,GO:0071347,GO:0071356,GO:0071773,GO:1901509,GO:1902203,GO:1902548,GO:2001113" metalloendopeptidase activity|protein binding|cell-matrix adhesion|cell migration|proteoglycan catabolic process|extracellular matrix organization|extracellular matrix|negative regulation of chondrocyte differentiation|metal ion binding|regulation of inflammatory response|proteolysis involved in cellular protein catabolic process|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to BMP stimulus|regulation of endothelial tube morphogenesis|negative regulation of hepatocyte growth factor receptor signaling pathway|negative regulation of cellular response to vascular endothelial growth factor stimulus|negative regulation of cellular response to hepatocyte growth factor stimulus ADAMTS13 163.1043144 205.0211056 121.1875232 0.591097794 -0.758531259 0.188625959 1 1.738422188 1.071841392 11093 ADAM metallopeptidase with thrombospondin type 1 motif 13 "GO:0004222,GO:0005178,GO:0005509,GO:0005515,GO:0005615,GO:0005788,GO:0006508,GO:0007160,GO:0007229,GO:0008237,GO:0008270,GO:0009100,GO:0009636,GO:0009986,GO:0014075,GO:0016485,GO:0030168,GO:0030198,GO:0031012,GO:0035864,GO:0043171,GO:0071222,GO:0071346,GO:0071353,GO:0071356" metalloendopeptidase activity|integrin binding|calcium ion binding|protein binding|extracellular space|endoplasmic reticulum lumen|proteolysis|cell-matrix adhesion|integrin-mediated signaling pathway|metallopeptidase activity|zinc ion binding|glycoprotein metabolic process|response to toxic substance|cell surface|response to amine|protein processing|platelet activation|extracellular matrix organization|extracellular matrix|response to potassium ion|peptide catabolic process|cellular response to lipopolysaccharide|cellular response to interferon-gamma|cellular response to interleukin-4|cellular response to tumor necrosis factor ADAMTS16 60.79615927 81.19647747 40.39584108 0.49750731 -1.007210372 0.208148526 1 0.825931942 0.428607393 170690 ADAM metallopeptidase with thrombospondin type 1 motif 16 "GO:0001658,GO:0003073,GO:0004222,GO:0006508,GO:0030198,GO:0031012,GO:0046872,GO:0048232,GO:1902017" branching involved in ureteric bud morphogenesis|regulation of systemic arterial blood pressure|metalloendopeptidase activity|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding|male gamete generation|regulation of cilium assembly ADAMTS18 14.1203089 22.3290313 5.911586499 0.264748901 -1.917303399 0.133452681 1 0.200582948 0.055391625 170692 ADAM metallopeptidase with thrombospondin type 1 motif 18 "GO:0001654,GO:0004222,GO:0006508,GO:0030198,GO:0031012,GO:0046872,GO:0090331" eye development|metalloendopeptidase activity|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding|negative regulation of platelet aggregation ADAMTS19 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.028602236 0.011584612 171019 ADAM metallopeptidase with thrombospondin type 1 motif 19 "GO:0004222,GO:0006508,GO:0030198,GO:0031012,GO:0046872" metalloendopeptidase activity|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding ADAMTS2 36.19968362 16.23929549 56.16007174 3.45828252 1.790055733 0.061060051 1 0.112527436 0.40591474 9509 ADAM metallopeptidase with thrombospondin type 1 motif 2 "GO:0004222,GO:0005576,GO:0007283,GO:0008237,GO:0008270,GO:0016485,GO:0030198,GO:0030199,GO:0030324,GO:0030574,GO:0031012,GO:0043588,GO:0062023" metalloendopeptidase activity|extracellular region|spermatogenesis|metallopeptidase activity|zinc ion binding|protein processing|extracellular matrix organization|collagen fibril organization|lung development|collagen catabolic process|extracellular matrix|skin development|collagen-containing extracellular matrix ADAMTS3 215.753856 234.4548287 197.0528833 0.840472702 -0.250727133 0.637946213 1 1.691497146 1.482896402 9508 ADAM metallopeptidase with thrombospondin type 1 motif 3 "GO:0001701,GO:0004175,GO:0004222,GO:0005515,GO:0005576,GO:0005615,GO:0008201,GO:0008270,GO:0010573,GO:0016485,GO:0030198,GO:0030199,GO:0030574,GO:0031012,GO:0032964,GO:0062023,GO:0070062,GO:0097435,GO:1900748" in utero embryonic development|endopeptidase activity|metalloendopeptidase activity|protein binding|extracellular region|extracellular space|heparin binding|zinc ion binding|vascular endothelial growth factor production|protein processing|extracellular matrix organization|collagen fibril organization|collagen catabolic process|extracellular matrix|collagen biosynthetic process|collagen-containing extracellular matrix|extracellular exosome|supramolecular fiber organization|positive regulation of vascular endothelial growth factor signaling pathway ADAMTS6 413.4126945 309.5615704 517.2638187 1.670956179 0.740673899 0.085326615 1 1.140813612 1.988363054 11174 ADAM metallopeptidase with thrombospondin type 1 motif 6 "GO:0001822,GO:0003279,GO:0004222,GO:0006508,GO:0008237,GO:0030198,GO:0031012,GO:0035904,GO:0046872,GO:0060976" kidney development|cardiac septum development|metalloendopeptidase activity|proteolysis|metallopeptidase activity|extracellular matrix organization|extracellular matrix|aorta development|metal ion binding|coronary vasculature development ADAMTS7 1168.252668 1497.060053 839.4452829 0.560729198 -0.8346239 0.015552331 0.551822764 13.31591331 7.788253157 11173 ADAM metallopeptidase with thrombospondin type 1 motif 7 "GO:0004222,GO:0005515,GO:0005788,GO:0008237,GO:0030198,GO:0031012,GO:0032331,GO:0046872,GO:0051603,GO:0071347,GO:0071356,GO:0071773" metalloendopeptidase activity|protein binding|endoplasmic reticulum lumen|metallopeptidase activity|extracellular matrix organization|extracellular matrix|negative regulation of chondrocyte differentiation|metal ion binding|proteolysis involved in cellular protein catabolic process|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to BMP stimulus ADAMTS9 509.9305049 778.4712277 241.3897821 0.310081829 -1.68927911 5.07E-05 0.009048336 5.171408893 1.672634786 56999 ADAM metallopeptidase with thrombospondin type 1 motif 9 "GO:0003179,GO:0003229,GO:0004222,GO:0005783,GO:0006508,GO:0006516,GO:0007275,GO:0008237,GO:0008270,GO:0010596,GO:0015031,GO:0016192,GO:0030198,GO:0031012,GO:0035909,GO:0043231,GO:0062023,GO:0090673,GO:1903671" heart valve morphogenesis|ventricular cardiac muscle tissue development|metalloendopeptidase activity|endoplasmic reticulum|proteolysis|glycoprotein catabolic process|multicellular organism development|metallopeptidase activity|zinc ion binding|negative regulation of endothelial cell migration|protein transport|vesicle-mediated transport|extracellular matrix organization|extracellular matrix|aorta morphogenesis|intracellular membrane-bounded organelle|collagen-containing extracellular matrix|endothelial cell-matrix adhesion|negative regulation of sprouting angiogenesis ADAMTSL4 102.1893889 115.7049804 88.67379749 0.766378398 -0.383871199 0.574154905 1 1.078007556 0.861749399 54507 ADAMTS like 4 "GO:0002020,GO:0002064,GO:0004222,GO:0005515,GO:0005614,GO:0005788,GO:0006508,GO:0006915,GO:0030198,GO:0031012,GO:0043065,GO:0062023" protease binding|epithelial cell development|metalloendopeptidase activity|protein binding|interstitial matrix|endoplasmic reticulum lumen|proteolysis|apoptotic process|extracellular matrix organization|extracellular matrix|positive regulation of apoptotic process|collagen-containing extracellular matrix ADAMTSL5 241.0468454 178.6322504 303.4614403 1.698805448 0.764520641 0.132431711 1 3.421744821 6.063273987 339366 ADAMTS like 5 "GO:0001527,GO:0004222,GO:0005515,GO:0005576,GO:0006508,GO:0008201,GO:0030198,GO:0031012,GO:0050436" microfibril|metalloendopeptidase activity|protein binding|extracellular region|proteolysis|heparin binding|extracellular matrix organization|extracellular matrix|microfibril binding ADAP1 97.35214151 121.7947162 72.90956682 0.598626682 -0.740271511 0.280195794 1 2.223674373 1.388491389 11033 ArfGAP with dual PH domains 1 "GO:0005096,GO:0005515,GO:0005547,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007166,GO:0043087,GO:0043231,GO:0043533,GO:0043547,GO:0046872,GO:1902936" "GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|cytoplasm|cytosol|plasma membrane|cell surface receptor signaling pathway|regulation of GTPase activity|intracellular membrane-bounded organelle|inositol 1,3,4,5 tetrakisphosphate binding|positive regulation of GTPase activity|metal ion binding|phosphatidylinositol bisphosphate binding" ADAP2 164.7833709 117.7348923 211.8318496 1.799227445 0.847377573 0.140977766 1 2.064701161 3.874888399 55803 ArfGAP with dual PH domains 2 "GO:0005096,GO:0005515,GO:0005546,GO:0005547,GO:0005737,GO:0005740,GO:0005886,GO:0007507,GO:0030674,GO:0043231,GO:0043325,GO:0043533,GO:0043547,GO:0046872,GO:0048017" "GTPase activator activity|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|mitochondrial envelope|plasma membrane|heart development|protein-macromolecule adaptor activity|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|inositol 1,3,4,5 tetrakisphosphate binding|positive regulation of GTPase activity|metal ion binding|inositol lipid-mediated signaling" ADAR 7565.753934 7740.054215 7391.453653 0.954961483 -0.066485549 0.840254112 1 56.03293892 55.81426203 103 adenosine deaminase RNA specific "GO:0001649,GO:0002244,GO:0002566,GO:0003677,GO:0003723,GO:0003725,GO:0003726,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006382,GO:0006396,GO:0006397,GO:0008251,GO:0009615,GO:0016020,GO:0016553,GO:0030218,GO:0031054,GO:0035280,GO:0035455,GO:0043066,GO:0044387,GO:0044530,GO:0045070,GO:0045087,GO:0046872,GO:0051607,GO:0060216,GO:0060337,GO:0060339,GO:0061484,GO:0098586,GO:1900369" osteoblast differentiation|hematopoietic progenitor cell differentiation|somatic diversification of immune receptors via somatic mutation|DNA binding|RNA binding|double-stranded RNA binding|double-stranded RNA adenosine deaminase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|adenosine to inosine editing|RNA processing|mRNA processing|tRNA-specific adenosine deaminase activity|response to virus|membrane|base conversion or substitution editing|erythrocyte differentiation|pre-miRNA processing|miRNA loading onto RISC involved in gene silencing by miRNA|response to interferon-alpha|negative regulation of apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|supraspliceosomal complex|positive regulation of viral genome replication|innate immune response|metal ion binding|defense response to virus|definitive hemopoiesis|type I interferon signaling pathway|negative regulation of type I interferon-mediated signaling pathway|hematopoietic stem cell homeostasis|cellular response to virus|negative regulation of RNA interference "hsa04623,hsa05162,hsa05164,hsa05171" Cytosolic DNA-sensing pathway|Measles|Influenza A|Coronavirus disease - COVID-19 ADARB1 1058.152956 1177.348923 938.956989 0.797518026 -0.326410967 0.349878188 1 4.715584779 3.922762318 104 adenosine deaminase RNA specific B1 "GO:0003723,GO:0003725,GO:0003726,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006382,GO:0006396,GO:0006397,GO:0007274,GO:0008251,GO:0008285,GO:0016553,GO:0021610,GO:0021618,GO:0021965,GO:0030336,GO:0035264,GO:0044387,GO:0045070,GO:0045087,GO:0045202,GO:0046872,GO:0050884,GO:0051607,GO:0051726,GO:0060384,GO:0060415,GO:0061744,GO:0097049" RNA binding|double-stranded RNA binding|double-stranded RNA adenosine deaminase activity|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|adenosine to inosine editing|RNA processing|mRNA processing|neuromuscular synaptic transmission|tRNA-specific adenosine deaminase activity|negative regulation of cell population proliferation|base conversion or substitution editing|facial nerve morphogenesis|hypoglossal nerve morphogenesis|spinal cord ventral commissure morphogenesis|negative regulation of cell migration|multicellular organism growth|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of viral genome replication|innate immune response|synapse|metal ion binding|neuromuscular process controlling posture|defense response to virus|regulation of cell cycle|innervation|muscle tissue morphogenesis|motor behavior|motor neuron apoptotic process ADAT1 1106.937153 1009.881189 1203.993117 1.192212639 0.253641573 0.464600078 1 8.629478581 10.73134622 23536 adenosine deaminase tRNA specific 1 "GO:0003723,GO:0008033,GO:0008251,GO:0046872" RNA binding|tRNA processing|tRNA-specific adenosine deaminase activity|metal ion binding ADAT2 181.3910892 209.0809295 153.701249 0.735128017 -0.44393259 0.426864128 1 1.05554341 0.809384723 134637 adenosine deaminase tRNA specific 2 "GO:0002100,GO:0005515,GO:0005654,GO:0006400,GO:0008270,GO:0052717" tRNA wobble adenosine to inosine editing|protein binding|nucleoplasm|tRNA modification|zinc ion binding|tRNA-specific adenosine-34 deaminase activity ADAT3 78.6348392 88.30116925 68.96850916 0.781059976 -0.35649476 0.635677371 1 2.79683722 2.27859691 113179 adenosine deaminase tRNA specific 3 "GO:0005515,GO:0005654,GO:0006400,GO:0046872,GO:0052717" protein binding|nucleoplasm|tRNA modification|metal ion binding|tRNA-specific adenosine-34 deaminase activity ADCK1 103.6524398 114.6900244 92.61485516 0.807523197 -0.308424392 0.652760864 1 1.685619598 1.419810908 57143 aarF domain containing kinase 1 "GO:0004674,GO:0005524,GO:0005576,GO:0005743,GO:0006468,GO:0007005,GO:0010637,GO:0032592,GO:0055088,GO:1903852" protein serine/threonine kinase activity|ATP binding|extracellular region|mitochondrial inner membrane|protein phosphorylation|mitochondrion organization|negative regulation of mitochondrial fusion|integral component of mitochondrial membrane|lipid homeostasis|positive regulation of cristae formation ADCK2 904.860954 733.8131651 1075.908743 1.466188935 0.552071023 0.124169377 1 14.16350918 21.66091188 90956 aarF domain containing kinase 2 "GO:0004674,GO:0005515,GO:0005524,GO:0006468,GO:0016021" protein serine/threonine kinase activity|protein binding|ATP binding|protein phosphorylation|integral component of membrane ADCK5 370.6103539 347.1149412 394.1057666 1.135375404 0.183169394 0.68302638 1 5.685687976 6.733462317 203054 aarF domain containing kinase 5 "GO:0004674,GO:0005515,GO:0006468,GO:0016021" protein serine/threonine kinase activity|protein binding|protein phosphorylation|integral component of membrane ADCY3 1608.142301 1326.547451 1889.737151 1.424553 0.510509298 0.120874822 1 13.50994341 20.07465413 109 adenylate cyclase 3 "GO:0003091,GO:0004016,GO:0005516,GO:0005524,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0005929,GO:0006171,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0007338,GO:0007340,GO:0007608,GO:0008355,GO:0016020,GO:0016021,GO:0030317,GO:0034199,GO:0046872,GO:0071377,GO:1904322" renal water homeostasis|adenylate cyclase activity|calmodulin binding|ATP binding|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|cilium|cAMP biosynthetic process|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|single fertilization|acrosome reaction|sensory perception of smell|olfactory learning|membrane|integral component of membrane|flagellated sperm motility|activation of protein kinase A activity|metal ion binding|cellular response to glucagon stimulus|cellular response to forskolin "hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04740,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05110,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Vibrio cholerae infection|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY4 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.041566528 0.042088677 196883 adenylate cyclase 4 "GO:0003091,GO:0004016,GO:0005080,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0005887,GO:0006171,GO:0007186,GO:0007188,GO:0007189,GO:0007190,GO:0007193,GO:0016020,GO:0030425,GO:0034199,GO:0046872,GO:0071377" renal water homeostasis|adenylate cyclase activity|protein kinase C binding|protein binding|ATP binding|cytoplasm|plasma membrane|integral component of plasma membrane|cAMP biosynthetic process|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|membrane|dendrite|activation of protein kinase A activity|metal ion binding|cellular response to glucagon stimulus "hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04742,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY5 38.15536668 15.22433953 61.08639383 4.012416678 2.004471434 0.034834417 0.836264269 0.089108874 0.37294339 111 adenylate cyclase 5 "GO:0001973,GO:0003091,GO:0004016,GO:0005524,GO:0005886,GO:0005887,GO:0005929,GO:0006171,GO:0007186,GO:0007189,GO:0007190,GO:0007191,GO:0007193,GO:0007195,GO:0007204,GO:0007626,GO:0008179,GO:0016021,GO:0034199,GO:0045111,GO:0046872,GO:0050885,GO:0061178,GO:0071377,GO:0097110,GO:1904322" G protein-coupled adenosine receptor signaling pathway|renal water homeostasis|adenylate cyclase activity|ATP binding|plasma membrane|integral component of plasma membrane|cilium|cAMP biosynthetic process|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-activating dopamine receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting dopamine receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|locomotory behavior|adenylate cyclase binding|integral component of membrane|activation of protein kinase A activity|intermediate filament cytoskeleton|metal ion binding|neuromuscular process controlling balance|regulation of insulin secretion involved in cellular response to glucose stimulus|cellular response to glucagon stimulus|scaffold protein binding|cellular response to forskolin "hsa00230,hsa01522,hsa04015,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa04976,hsa05012,hsa05030,hsa05031,hsa05032,hsa05034,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Parkinson disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY6 2062.351672 1663.512832 2461.190513 1.479513993 0.565123341 0.079361834 1 11.63688625 17.95857181 112 adenylate cyclase 6 "GO:0003091,GO:0004016,GO:0005080,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0005929,GO:0006171,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0007212,GO:0010977,GO:0016020,GO:0019901,GO:0031226,GO:0032420,GO:0034199,GO:0035811,GO:0046872,GO:0071377,GO:0071380,GO:0071870,GO:0097746,GO:1904117,GO:1904322" renal water homeostasis|adenylate cyclase activity|protein kinase C binding|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|cilium|cAMP biosynthetic process|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|negative regulation of neuron projection development|membrane|protein kinase binding|intrinsic component of plasma membrane|stereocilium|activation of protein kinase A activity|negative regulation of urine volume|metal ion binding|cellular response to glucagon stimulus|cellular response to prostaglandin E stimulus|cellular response to catecholamine stimulus|blood vessel diameter maintenance|cellular response to vasopressin|cellular response to forskolin "hsa00230,hsa01522,hsa04015,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04742,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04961,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY7 825.4350832 827.1891142 823.6810522 0.995759057 -0.006131398 0.990363879 1 6.154577712 6.392466411 113 adenylate cyclase 7 "GO:0002819,GO:0003091,GO:0004016,GO:0005524,GO:0005886,GO:0005887,GO:0006171,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0016021,GO:0034199,GO:0046872,GO:0060135,GO:0071285,GO:0071361,GO:0071377,GO:1900016" regulation of adaptive immune response|renal water homeostasis|adenylate cyclase activity|ATP binding|plasma membrane|integral component of plasma membrane|cAMP biosynthetic process|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|integral component of membrane|activation of protein kinase A activity|metal ion binding|maternal process involved in female pregnancy|cellular response to lithium ion|cellular response to ethanol|cellular response to glucagon stimulus|negative regulation of cytokine production involved in inflammatory response "hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY8 6.522984915 8.119647747 4.926322083 0.606716232 -0.720906186 0.726457076 1 0.07810665 0.04942988 114 adenylate cyclase 8 "GO:0003091,GO:0003779,GO:0004016,GO:0005516,GO:0005524,GO:0005886,GO:0005887,GO:0005901,GO:0005905,GO:0006171,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0007204,GO:0007611,GO:0007613,GO:0007616,GO:0007626,GO:0008294,GO:0010255,GO:0014069,GO:0015629,GO:0016020,GO:0016323,GO:0016324,GO:0030424,GO:0030425,GO:0030665,GO:0031915,GO:0032793,GO:0032809,GO:0034199,GO:0035774,GO:0038003,GO:0042593,GO:0042803,GO:0044853,GO:0045121,GO:0046872,GO:0046982,GO:0046983,GO:0048786,GO:0051259,GO:0051260,GO:0051480,GO:0051721,GO:0060076,GO:0071277,GO:0071315,GO:0071333,GO:0071377,GO:0080135,GO:0098685,GO:0098686,GO:0098978,GO:0099056,GO:0150076,GO:1900273,GO:1900454,GO:1904322" renal water homeostasis|actin binding|adenylate cyclase activity|calmodulin binding|ATP binding|plasma membrane|integral component of plasma membrane|caveola|clathrin-coated pit|cAMP biosynthetic process|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|learning or memory|memory|long-term memory|locomotory behavior|calcium- and calmodulin-responsive adenylate cyclase activity|glucose mediated signaling pathway|postsynaptic density|actin cytoskeleton|membrane|basolateral plasma membrane|apical plasma membrane|axon|dendrite|clathrin-coated vesicle membrane|positive regulation of synaptic plasticity|positive regulation of CREB transcription factor activity|neuronal cell body membrane|activation of protein kinase A activity|positive regulation of insulin secretion involved in cellular response to glucose stimulus|opioid receptor signaling pathway|glucose homeostasis|protein homodimerization activity|plasma membrane raft|membrane raft|metal ion binding|protein heterodimerization activity|protein dimerization activity|presynaptic active zone|protein complex oligomerization|protein homooligomerization|regulation of cytosolic calcium ion concentration|protein phosphatase 2A binding|excitatory synapse|cellular response to calcium ion|cellular response to morphine|cellular response to glucose stimulus|cellular response to glucagon stimulus|regulation of cellular response to stress|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|integral component of presynaptic membrane|neuroinflammatory response|positive regulation of long-term synaptic potentiation|positive regulation of long-term synaptic depression|cellular response to forskolin "hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04720,hsa04723,hsa04724,hsa04725,hsa04727,hsa04742,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY9 605.3272094 530.8219715 679.8324474 1.280716481 0.356951134 0.360722999 1 3.475663895 4.643085709 115 adenylate cyclase 9 "GO:0001701,GO:0003091,GO:0004016,GO:0005524,GO:0005886,GO:0005887,GO:0006171,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0016021,GO:0030424,GO:0030425,GO:0034199,GO:0046872,GO:0071377,GO:0071880" in utero embryonic development|renal water homeostasis|adenylate cyclase activity|ATP binding|plasma membrane|integral component of plasma membrane|cAMP biosynthetic process|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|integral component of membrane|axon|dendrite|activation of protein kinase A activity|metal ion binding|cellular response to glucagon stimulus|adenylate cyclase-activating adrenergic receptor signaling pathway "hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04961,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05110,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Vibrio cholerae infection|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADD1 3193.30211 2934.237705 3452.366516 1.176580381 0.234599885 0.46090383 1 38.7002053 47.49531813 118 adducin 1 "GO:0000902,GO:0001701,GO:0003723,GO:0003779,GO:0005200,GO:0005515,GO:0005516,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0006884,GO:0008134,GO:0008290,GO:0014069,GO:0016604,GO:0020027,GO:0030036,GO:0030218,GO:0030507,GO:0032092,GO:0035264,GO:0036498,GO:0042803,GO:0045296,GO:0046982,GO:0048873,GO:0051015,GO:0051016,GO:0051017,GO:0055085,GO:0071277,GO:1903142,GO:1903393" cell morphogenesis|in utero embryonic development|RNA binding|actin binding|structural constituent of cytoskeleton|protein binding|calmodulin binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|cell volume homeostasis|transcription factor binding|F-actin capping protein complex|postsynaptic density|nuclear body|hemoglobin metabolic process|actin cytoskeleton organization|erythrocyte differentiation|spectrin binding|positive regulation of protein binding|multicellular organism growth|IRE1-mediated unfolded protein response|protein homodimerization activity|cadherin binding|protein heterodimerization activity|homeostasis of number of cells within a tissue|actin filament binding|barbed-end actin filament capping|actin filament bundle assembly|transmembrane transport|cellular response to calcium ion|positive regulation of establishment of endothelial barrier|positive regulation of adherens junction organization ADD3 816.5988789 627.2427885 1005.954969 1.603772874 0.681469842 0.063043586 1 5.996155994 10.03071096 120 adducin 3 "GO:0000794,GO:0005200,GO:0005516,GO:0005829,GO:0005856,GO:0005886,GO:0005903,GO:0005911,GO:0005938,GO:0014069,GO:0016020,GO:0051015,GO:0051016,GO:0055085" condensed nuclear chromosome|structural constituent of cytoskeleton|calmodulin binding|cytosol|cytoskeleton|plasma membrane|brush border|cell-cell junction|cell cortex|postsynaptic density|membrane|actin filament binding|barbed-end actin filament capping|transmembrane transport ADGRA2 241.2074273 223.290313 259.1245416 1.160482683 0.214724995 0.676705937 1 1.855737879 2.246317945 25960 adhesion G protein-coupled receptor A2 "GO:0002040,GO:0004930,GO:0005515,GO:0005886,GO:0007166,GO:0007186,GO:0007417,GO:0009986,GO:0010595,GO:0016021,GO:0016055,GO:0030175,GO:0043542,GO:0045765,GO:0050920,GO:0090210,GO:0090263,GO:1900747,GO:1990909" sprouting angiogenesis|G protein-coupled receptor activity|protein binding|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|central nervous system development|cell surface|positive regulation of endothelial cell migration|integral component of membrane|Wnt signaling pathway|filopodium|endothelial cell migration|regulation of angiogenesis|regulation of chemotaxis|regulation of establishment of blood-brain barrier|positive regulation of canonical Wnt signaling pathway|negative regulation of vascular endothelial growth factor signaling pathway|Wnt signalosome ADGRA3 740.5066267 847.4882336 633.5250198 0.747532526 -0.419791741 0.260821795 1 7.574076102 5.905758561 166647 adhesion G protein-coupled receptor A3 "GO:0004930,GO:0005886,GO:0007166,GO:0007186,GO:0009897,GO:0016021" G protein-coupled receptor activity|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|external side of plasma membrane|integral component of membrane ADGRB1 25.04729214 28.41876711 21.67581716 0.762728977 -0.390757585 0.732998728 1 0.224017167 0.178224529 575 adhesion G protein-coupled receptor B1 "GO:0001530,GO:0001786,GO:0001891,GO:0004930,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0006910,GO:0007155,GO:0007165,GO:0007166,GO:0007186,GO:0007189,GO:0007409,GO:0007422,GO:0007517,GO:0008285,GO:0010596,GO:0014069,GO:0016021,GO:0016525,GO:0030165,GO:0030425,GO:0031397,GO:0042177,GO:0043197,GO:0043277,GO:0043652,GO:0045087,GO:0048167,GO:0048471,GO:0050829,GO:0051965,GO:1901741,GO:1903428" "lipopolysaccharide binding|phosphatidylserine binding|phagocytic cup|G protein-coupled receptor activity|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|phagocytosis, recognition|cell adhesion|signal transduction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|axonogenesis|peripheral nervous system development|muscle organ development|negative regulation of cell population proliferation|negative regulation of endothelial cell migration|postsynaptic density|integral component of membrane|negative regulation of angiogenesis|PDZ domain binding|dendrite|negative regulation of protein ubiquitination|negative regulation of protein catabolic process|dendritic spine|apoptotic cell clearance|engulfment of apoptotic cell|innate immune response|regulation of synaptic plasticity|perinuclear region of cytoplasm|defense response to Gram-negative bacterium|positive regulation of synapse assembly|positive regulation of myoblast fusion|positive regulation of reactive oxygen species biosynthetic process" hsa04115 p53 signaling pathway ADGRB2 315.5570344 321.741042 309.3730268 0.9615591 -0.056552562 0.910064988 1 2.736823773 2.744977226 576 adhesion G protein-coupled receptor B2 "GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0007422,GO:0016021,GO:0016525,GO:0033173" G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|peripheral nervous system development|integral component of membrane|negative regulation of angiogenesis|calcineurin-NFAT signaling cascade ADGRB3 67.36640312 58.86744617 75.86536007 1.288748961 0.365971264 0.645303507 1 0.489561326 0.658099196 577 adhesion G protein-coupled receptor B3 "GO:0004930,GO:0005096,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0007520,GO:0016021,GO:0016322,GO:0016525,GO:0043083,GO:0043547,GO:0048814,GO:0051965,GO:0061743,GO:0098794,GO:0099558" G protein-coupled receptor activity|GTPase activator activity|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|myoblast fusion|integral component of membrane|neuron remodeling|negative regulation of angiogenesis|synaptic cleft|positive regulation of GTPase activity|regulation of dendrite morphogenesis|positive regulation of synapse assembly|motor learning|postsynapse|maintenance of synapse structure ADGRE1 212.0678981 218.2155332 205.9202631 0.943655385 -0.083667999 0.88271784 1 3.233425084 3.182673995 2015 adhesion G protein-coupled receptor E1 "GO:0002250,GO:0004930,GO:0005509,GO:0005887,GO:0007155,GO:0007166,GO:0007186,GO:0007189" adaptive immune response|G protein-coupled receptor activity|calcium ion binding|integral component of plasma membrane|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway ADGRE2 7.597323987 14.20938356 0.985264417 0.069338998 -3.850189203 0.042413883 0.940614529 0.08918765 0.006450572 30817 adhesion G protein-coupled receptor E2 "GO:0004930,GO:0005509,GO:0005515,GO:0005886,GO:0005887,GO:0006954,GO:0007155,GO:0007166,GO:0007186,GO:0007189,GO:0016021,GO:0016477,GO:0031256,GO:0032587,GO:0035374,GO:0043304,GO:0071621" G protein-coupled receptor activity|calcium ion binding|protein binding|plasma membrane|integral component of plasma membrane|inflammatory response|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|integral component of membrane|cell migration|leading edge membrane|ruffle membrane|chondroitin sulfate binding|regulation of mast cell degranulation|granulocyte chemotaxis ADGRE5 2060.973491 1906.087309 2215.859673 1.162517406 0.217252317 0.499653995 1 27.66091631 33.54145951 976 adhesion G protein-coupled receptor E5 "GO:0004888,GO:0004930,GO:0005509,GO:0005515,GO:0005886,GO:0005887,GO:0005925,GO:0006954,GO:0006955,GO:0007155,GO:0007166,GO:0007186,GO:0007189,GO:0007267,GO:0016020,GO:0030667,GO:0043312,GO:0070062" transmembrane signaling receptor activity|G protein-coupled receptor activity|calcium ion binding|protein binding|plasma membrane|integral component of plasma membrane|focal adhesion|inflammatory response|immune response|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|cell-cell signaling|membrane|secretory granule membrane|neutrophil degranulation|extracellular exosome ADGRF1 235.0028846 337.9803375 132.0254318 0.390630511 -1.356123458 0.008841154 0.394187506 2.832149532 1.15397997 266977 adhesion G protein-coupled receptor F1 "GO:0004930,GO:0005576,GO:0005886,GO:0007166,GO:0007186,GO:0007189,GO:0007416,GO:0007613,GO:0016021,GO:0031175,GO:0032793" G protein-coupled receptor activity|extracellular region|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|synapse assembly|memory|integral component of membrane|neuron projection development|positive regulation of CREB transcription factor activity ADGRF3 6.015506931 7.104691779 4.926322083 0.693389979 -0.528261108 0.84291128 1 0.057388768 0.041506909 165082 adhesion G protein-coupled receptor F3 "GO:0004930,GO:0007166,GO:0007186,GO:0016021" G protein-coupled receptor activity|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|integral component of membrane ADGRF4 33.65957209 44.65806261 22.66108158 0.507435394 -0.978703944 0.308700089 1 0.744004384 0.393796798 221393 adhesion G protein-coupled receptor F4 "GO:0004930,GO:0005515,GO:0007166,GO:0007186,GO:0016021" G protein-coupled receptor activity|protein binding|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|integral component of membrane ADGRF5 1674.875287 2015.702553 1334.04802 0.661827817 -0.595472165 0.069367481 1 16.38392286 11.31042283 221395 adhesion G protein-coupled receptor F5 "GO:0003094,GO:0004930,GO:0005515,GO:0005886,GO:0006112,GO:0007166,GO:0007186,GO:0009986,GO:0016021,GO:0031410,GO:0042593,GO:0043031,GO:0043129,GO:0045177,GO:0045444,GO:0048821,GO:0061626,GO:0071073" glomerular filtration|G protein-coupled receptor activity|protein binding|plasma membrane|energy reserve metabolic process|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|cell surface|integral component of membrane|cytoplasmic vesicle|glucose homeostasis|negative regulation of macrophage activation|surfactant homeostasis|apical part of cell|fat cell differentiation|erythrocyte development|pharyngeal arch artery morphogenesis|positive regulation of phospholipid biosynthetic process ADGRG1 1213.508275 2132.42249 294.5940605 0.13814995 -2.855693054 8.05E-15 2.18E-11 18.91081708 2.725065566 9289 adhesion G protein-coupled receptor G1 "GO:0001525,GO:0004930,GO:0005515,GO:0005518,GO:0005887,GO:0007155,GO:0007166,GO:0007186,GO:0007189,GO:0007266,GO:0007267,GO:0007420,GO:0008201,GO:0008285,GO:0010573,GO:0016021,GO:0016477,GO:0021796,GO:0021801,GO:0021819,GO:0035025,GO:0045121,GO:0045785,GO:0050840,GO:0061484,GO:0070062,GO:0070528,GO:0072520,GO:0097451,GO:2000179,GO:2001223" angiogenesis|G protein-coupled receptor activity|protein binding|collagen binding|integral component of plasma membrane|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|Rho protein signal transduction|cell-cell signaling|brain development|heparin binding|negative regulation of cell population proliferation|vascular endothelial growth factor production|integral component of membrane|cell migration|cerebral cortex regionalization|cerebral cortex radial glia guided migration|layer formation in cerebral cortex|positive regulation of Rho protein signal transduction|membrane raft|positive regulation of cell adhesion|extracellular matrix binding|hematopoietic stem cell homeostasis|extracellular exosome|protein kinase C signaling|seminiferous tubule development|glial limiting end-foot|positive regulation of neural precursor cell proliferation|negative regulation of neuron migration ADGRG3 7.597323987 14.20938356 0.985264417 0.069338998 -3.850189203 0.042413883 0.940614529 0.101963042 0.007374563 222487 adhesion G protein-coupled receptor G3 "GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0016021,GO:0030183,GO:0030334,GO:0032792,GO:0035579,GO:0043312,GO:1901223" G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|integral component of membrane|B cell differentiation|regulation of cell migration|negative regulation of CREB transcription factor activity|specific granule membrane|neutrophil degranulation|negative regulation of NIK/NF-kappaB signaling ADGRG6 437.2817272 324.7859099 549.7775444 1.692738286 0.759358936 0.073313406 1 2.014112962 3.556227788 57211 adhesion G protein-coupled receptor G6 "GO:0004930,GO:0005518,GO:0005737,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0009986,GO:0014037,GO:0016021,GO:0019933,GO:0022011,GO:0042552,GO:0043236,GO:0050840,GO:0060347" G protein-coupled receptor activity|collagen binding|cytoplasm|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|cell surface|Schwann cell differentiation|integral component of membrane|cAMP-mediated signaling|myelination in peripheral nervous system|myelination|laminin binding|extracellular matrix binding|heart trabecula formation ADGRL1 858.8638039 957.1034782 760.6241296 0.794714623 -0.331491205 0.360494313 1 5.708185906 4.73178761 22859 adhesion G protein-coupled receptor L1 "GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007157,GO:0007166,GO:0007186,GO:0007189,GO:0014069,GO:0016021,GO:0016524,GO:0030246,GO:0030424,GO:0030426,GO:0035584,GO:0042734,GO:0043005,GO:0045202,GO:0050839,GO:0090129" G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|postsynaptic density|integral component of membrane|latrotoxin receptor activity|carbohydrate binding|axon|growth cone|calcium-mediated signaling using intracellular calcium source|presynaptic membrane|neuron projection|synapse|cell adhesion molecule binding|positive regulation of synapse maturation ADGRL2 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.019485951 0.009865365 23266 adhesion G protein-coupled receptor L2 "GO:0004930,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0007420,GO:0009617,GO:0016021,GO:0016524,GO:0030246,GO:0043005,GO:0050808,GO:0051965,GO:0098978,GO:0099055" G protein-coupled receptor activity|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|brain development|response to bacterium|integral component of membrane|latrotoxin receptor activity|carbohydrate binding|neuron projection|synapse organization|positive regulation of synapse assembly|glutamatergic synapse|integral component of postsynaptic membrane ADGRV1 361.7847899 383.653356 339.9162237 0.885998306 -0.174624154 0.699481363 1 1.001891773 0.925911827 84059 adhesion G protein-coupled receptor V1 "GO:0001917,GO:0001965,GO:0002141,GO:0002142,GO:0004930,GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0007166,GO:0007186,GO:0007194,GO:0007399,GO:0007601,GO:0007605,GO:0009986,GO:0010739,GO:0010855,GO:0016020,GO:0016021,GO:0016787,GO:0030501,GO:0031647,GO:0043235,GO:0045184,GO:0045202,GO:0045494,GO:0048496,GO:0048839,GO:0050877,GO:0050910,GO:0050953,GO:0060122,GO:0060171,GO:0070062,GO:0071277,GO:0090037,GO:0097264,GO:0098609,GO:1990075,GO:1990696" photoreceptor inner segment|G-protein alpha-subunit binding|stereocilia ankle link|stereocilia ankle link complex|G protein-coupled receptor activity|calcium ion binding|protein binding|cytoplasm|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|nervous system development|visual perception|sensory perception of sound|cell surface|positive regulation of protein kinase A signaling|adenylate cyclase inhibitor activity|membrane|integral component of membrane|hydrolase activity|positive regulation of bone mineralization|regulation of protein stability|receptor complex|establishment of protein localization|synapse|photoreceptor cell maintenance|maintenance of animal organ identity|inner ear development|nervous system process|detection of mechanical stimulus involved in sensory perception of sound|sensory perception of light stimulus|inner ear receptor cell stereocilium organization|stereocilium membrane|extracellular exosome|cellular response to calcium ion|positive regulation of protein kinase C signaling|self proteolysis|cell-cell adhesion|periciliary membrane compartment|USH2 complex ADH5 2566.547256 2656.139769 2476.954743 0.932539308 -0.100763556 0.752747822 1 50.7255313 49.34119704 128 "alcohol dehydrogenase 5 (class III), chi polypeptide" "GO:0001523,GO:0003016,GO:0004024,GO:0005504,GO:0005739,GO:0005829,GO:0006069,GO:0008270,GO:0009055,GO:0010430,GO:0018119,GO:0018467,GO:0022900,GO:0032496,GO:0042802,GO:0045777,GO:0046294,GO:0051409,GO:0051775,GO:0051903,GO:0070062,GO:0106321,GO:0106322" "retinoid metabolic process|respiratory system process|alcohol dehydrogenase activity, zinc-dependent|fatty acid binding|mitochondrion|cytosol|ethanol oxidation|zinc ion binding|electron transfer activity|fatty acid omega-oxidation|peptidyl-cysteine S-nitrosylation|formaldehyde dehydrogenase activity|electron transport chain|response to lipopolysaccharide|identical protein binding|positive regulation of blood pressure|formaldehyde catabolic process|response to nitrosative stress|response to redox state|S-(hydroxymethyl)glutathione dehydrogenase activity|extracellular exosome|S-(hydroxymethyl)glutathione dehydrogenase NADP activity|S-(hydroxymethyl)glutathione dehydrogenase NAD activity" "hsa00010,hsa00071,hsa00350,hsa00830,hsa00980,hsa00982,hsa05204" Glycolysis / Gluconeogenesis|Fatty acid degradation|Tyrosine metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ADHFE1 45.07918754 50.74779842 39.41057666 0.776596776 -0.364762376 0.691954011 1 1.303345316 1.055774112 137872 alcohol dehydrogenase iron containing 1 "GO:0004022,GO:0005739,GO:0005759,GO:0006103,GO:0006539,GO:0046872,GO:0047988,GO:0055114" alcohol dehydrogenase (NAD+) activity|mitochondrion|mitochondrial matrix|2-oxoglutarate metabolic process|glutamate catabolic process via 2-oxoglutarate|metal ion binding|hydroxyacid-oxoacid transhydrogenase activity|oxidation-reduction process ADI1 626.0041542 698.2897062 553.7186021 0.792964005 -0.334672716 0.387862033 1 6.906055498 5.712148214 55256 acireductone dioxygenase 1 "GO:0005506,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006555,GO:0010309,GO:0016491,GO:0019509,GO:0055114" iron ion binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|methionine metabolic process|acireductone dioxygenase [iron(II)-requiring] activity|oxidoreductase activity|L-methionine salvage from methylthioadenosine|oxidation-reduction process hsa00270 Cysteine and methionine metabolism ADIPOR1 2836.092787 2459.238311 3212.947262 1.306480648 0.385685755 0.225907739 1 53.24999778 72.56688899 51094 adiponectin receptor 1 "GO:0005515,GO:0005886,GO:0009755,GO:0010633,GO:0010719,GO:0010906,GO:0016020,GO:0016021,GO:0019216,GO:0019395,GO:0019901,GO:0030308,GO:0031226,GO:0033210,GO:0033211,GO:0038023,GO:0042304,GO:0042593,GO:0042802,GO:0046426,GO:0046427,GO:0046628,GO:0046872,GO:0055100,GO:0097003,GO:0120162,GO:1901223" protein binding|plasma membrane|hormone-mediated signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|regulation of glucose metabolic process|membrane|integral component of membrane|regulation of lipid metabolic process|fatty acid oxidation|protein kinase binding|negative regulation of cell growth|intrinsic component of plasma membrane|leptin-mediated signaling pathway|adiponectin-activated signaling pathway|signaling receptor activity|regulation of fatty acid biosynthetic process|glucose homeostasis|identical protein binding|negative regulation of receptor signaling pathway via JAK-STAT|positive regulation of receptor signaling pathway via JAK-STAT|positive regulation of insulin receptor signaling pathway|metal ion binding|adiponectin binding|adipokinetic hormone receptor activity|positive regulation of cold-induced thermogenesis|negative regulation of NIK/NF-kappaB signaling "hsa04152,hsa04211,hsa04920,hsa04932" AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease ADIPOR2 2489.358147 2228.843307 2749.872987 1.233766851 0.303069789 0.342342304 1 26.00991949 33.47249111 79602 adiponectin receptor 2 "GO:0001934,GO:0005515,GO:0005886,GO:0007507,GO:0007565,GO:0007584,GO:0009750,GO:0009755,GO:0010629,GO:0014075,GO:0016021,GO:0019395,GO:0030308,GO:0031226,GO:0032496,GO:0033211,GO:0038023,GO:0042304,GO:0042493,GO:0042593,GO:0045471,GO:0046326,GO:0046872,GO:0055100,GO:0061042,GO:0061871,GO:0071398,GO:0097003,GO:0120162" positive regulation of protein phosphorylation|protein binding|plasma membrane|heart development|female pregnancy|response to nutrient|response to fructose|hormone-mediated signaling pathway|negative regulation of gene expression|response to amine|integral component of membrane|fatty acid oxidation|negative regulation of cell growth|intrinsic component of plasma membrane|response to lipopolysaccharide|adiponectin-activated signaling pathway|signaling receptor activity|regulation of fatty acid biosynthetic process|response to drug|glucose homeostasis|response to ethanol|positive regulation of glucose import|metal ion binding|adiponectin binding|vascular wound healing|negative regulation of hepatic stellate cell migration|cellular response to fatty acid|adipokinetic hormone receptor activity|positive regulation of cold-induced thermogenesis "hsa04152,hsa04211,hsa04920,hsa04932" AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease ADIRF 663.4051079 628.2577444 698.5524713 1.111888357 0.153011937 0.691155996 1 50.74806762 58.85679676 10974 adipogenesis regulatory factor "GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0030154,GO:0045600,GO:0045944,GO:0070062,GO:0071478,GO:0072719,GO:2001023" molecular_function|protein binding|nucleus|nucleoplasm|cytosol|cell differentiation|positive regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|extracellular exosome|cellular response to radiation|cellular response to cisplatin|regulation of response to drug ADK 1518.859826 1284.934256 1752.785397 1.36410512 0.447954825 0.176209025 1 14.93971237 21.25719737 132 adenosine kinase "GO:0003723,GO:0004001,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006166,GO:0006175,GO:0009156,GO:0016310,GO:0043101,GO:0044209,GO:0046872" RNA binding|adenosine kinase activity|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|purine ribonucleoside salvage|dATP biosynthetic process|ribonucleoside monophosphate biosynthetic process|phosphorylation|purine-containing compound salvage|AMP salvage|metal ion binding hsa00230 Purine metabolism ADM 471.1340483 753.0973285 189.170768 0.251190332 -1.993147157 3.60E-06 0.001108266 25.56415745 6.698080048 133 adrenomedullin "GO:0001570,GO:0001666,GO:0001843,GO:0002026,GO:0002031,GO:0003073,GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0005737,GO:0006954,GO:0007165,GO:0007186,GO:0007189,GO:0007204,GO:0007507,GO:0007565,GO:0007568,GO:0008209,GO:0008284,GO:0008285,GO:0009409,GO:0009611,GO:0010460,GO:0031100,GO:0031102,GO:0031623,GO:0031700,GO:0032496,GO:0032868,GO:0035809,GO:0042475,GO:0042594,GO:0043065,GO:0043116,GO:0045766,GO:0045906,GO:0046879,GO:0048589,GO:0051384,GO:0060670,GO:0097084,GO:0097647,GO:1990410,GO:2000184,GO:2001214" vasculogenesis|response to hypoxia|neural tube closure|regulation of the force of heart contraction|G protein-coupled receptor internalization|regulation of systemic arterial blood pressure|signaling receptor binding|hormone activity|extracellular region|extracellular space|cytoplasm|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|heart development|female pregnancy|aging|androgen metabolic process|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to cold|response to wounding|positive regulation of heart rate|animal organ regeneration|neuron projection regeneration|receptor internalization|adrenomedullin receptor binding|response to lipopolysaccharide|response to insulin|regulation of urine volume|odontogenesis of dentin-containing tooth|response to starvation|positive regulation of apoptotic process|negative regulation of vascular permeability|positive regulation of angiogenesis|negative regulation of vasoconstriction|hormone secretion|developmental growth|response to glucocorticoid|branching involved in labyrinthine layer morphogenesis|vascular associated smooth muscle cell development|amylin receptor signaling pathway|adrenomedullin receptor signaling pathway|positive regulation of progesterone biosynthetic process|positive regulation of vasculogenesis "hsa04080,hsa04270" Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction ADM2 111.3294359 66.98709391 155.6717778 2.32390702 1.216552348 0.064921907 1 0.805283644 1.952016821 79924 adrenomedullin 2 "GO:0001525,GO:0005179,GO:0005576,GO:0006468,GO:0007186,GO:0007189,GO:0007586,GO:0007631,GO:0010628,GO:0044877,GO:0045766,GO:0045776" angiogenesis|hormone activity|extracellular region|protein phosphorylation|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|digestion|feeding behavior|positive regulation of gene expression|protein-containing complex binding|positive regulation of angiogenesis|negative regulation of blood pressure ADM5 13.95700537 11.16451565 16.74949508 1.500243773 0.585196941 0.672252101 1 0.71756768 1.122898836 199800 adrenomedullin 5 (putative) "GO:0003674,GO:0005575,GO:0005576,GO:0008150" molecular_function|cellular_component|extracellular region|biological_process ADNP 3938.782072 4121.736188 3755.827956 0.911224733 -0.134121189 0.674122017 1 24.15265501 22.95653339 23394 activity dependent neuroprotector homeobox "GO:0000785,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0010468,GO:0046872,GO:0090575" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of gene expression|metal ion binding|RNA polymerase II transcription regulator complex" ADNP2 1161.445138 1132.690861 1190.199415 1.050771624 0.071449146 0.837462744 1 10.49904762 11.5073195 22850 ADNP homeobox 2 "GO:0000785,GO:0000981,GO:0003674,GO:0003677,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0010468,GO:0030182,GO:0030307,GO:0034599,GO:0046872,GO:0060548,GO:0071300" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|DNA binding|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|regulation of gene expression|neuron differentiation|positive regulation of cell growth|cellular response to oxidative stress|metal ion binding|negative regulation of cell death|cellular response to retinoic acid" ADO 1150.631478 1201.707867 1099.555089 0.914993668 -0.128166335 0.711189154 1 16.18677236 15.44878316 84890 2-aminoethanethiol dioxygenase "GO:0000098,GO:0005515,GO:0005829,GO:0046872,GO:0047800,GO:0055114" sulfur amino acid catabolic process|protein binding|cytosol|metal ion binding|cysteamine dioxygenase activity|oxidation-reduction process hsa00430 Taurine and hypotaurine metabolism ADORA1 208.8866966 236.4847406 181.2886526 0.766597676 -0.38345847 0.472787065 1 3.740511507 2.990986297 134 adenosine A1 receptor "GO:0000186,GO:0001609,GO:0001659,GO:0001664,GO:0001666,GO:0001883,GO:0001973,GO:0002087,GO:0002674,GO:0002686,GO:0002793,GO:0003084,GO:0003085,GO:0003093,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0006612,GO:0006909,GO:0006954,GO:0007165,GO:0007186,GO:0007193,GO:0007267,GO:0007399,GO:0008285,GO:0014050,GO:0014069,GO:0016042,GO:0016323,GO:0030673,GO:0031072,GO:0031683,GO:0032229,GO:0032244,GO:0032795,GO:0032900,GO:0035307,GO:0035814,GO:0042323,GO:0043025,GO:0043066,GO:0043195,GO:0043197,GO:0043268,GO:0044305,GO:0045741,GO:0045822,GO:0046888,GO:0046982,GO:0048786,GO:0050890,GO:0050965,GO:0050995,GO:0050996,GO:0051930,GO:0051967,GO:0055089,GO:0060079,GO:0060087,GO:0070256,GO:0070328,GO:0086004,GO:0097190,GO:0099055,GO:0099056,GO:0099509,GO:0099582,GO:1900272,GO:1900453,GO:1901216" "activation of MAPKK activity|G protein-coupled adenosine receptor activity|temperature homeostasis|G protein-coupled receptor binding|response to hypoxia|purine nucleoside binding|G protein-coupled adenosine receptor signaling pathway|regulation of respiratory gaseous exchange by nervous system process|negative regulation of acute inflammatory response|negative regulation of leukocyte migration|positive regulation of peptide secretion|positive regulation of systemic arterial blood pressure|negative regulation of systemic arterial blood pressure|regulation of glomerular filtration|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|protein targeting to membrane|phagocytosis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|cell-cell signaling|nervous system development|negative regulation of cell population proliferation|negative regulation of glutamate secretion|postsynaptic density|lipid catabolic process|basolateral plasma membrane|axolemma|heat shock protein binding|G-protein beta/gamma-subunit complex binding|negative regulation of synaptic transmission, GABAergic|positive regulation of nucleoside transport|heterotrimeric G-protein binding|negative regulation of neurotrophin production|positive regulation of protein dephosphorylation|negative regulation of renal sodium excretion|negative regulation of circadian sleep/wake cycle, non-REM sleep|neuronal cell body|negative regulation of apoptotic process|terminal bouton|dendritic spine|positive regulation of potassium ion transport|calyx of Held|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of heart contraction|negative regulation of hormone secretion|protein heterodimerization activity|presynaptic active zone|cognition|detection of temperature stimulus involved in sensory perception of pain|negative regulation of lipid catabolic process|positive regulation of lipid catabolic process|regulation of sensory perception of pain|negative regulation of synaptic transmission, glutamatergic|fatty acid homeostasis|excitatory postsynaptic potential|relaxation of vascular associated smooth muscle|negative regulation of mucus secretion|triglyceride homeostasis|regulation of cardiac muscle cell contraction|apoptotic signaling pathway|integral component of postsynaptic membrane|integral component of presynaptic membrane|regulation of presynaptic cytosolic calcium ion concentration|neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration|negative regulation of long-term synaptic potentiation|negative regulation of long-term synaptic depression|positive regulation of neuron death" "hsa04022,hsa04024,hsa04071,hsa04080,hsa04923,hsa04924,hsa05032" cGMP-PKG signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction|Regulation of lipolysis in adipocytes|Renin secretion|Morphine addiction ADORA2A 38.31594861 59.88240213 16.74949508 0.279706466 -1.838014489 0.050581398 1 1.095676451 0.319669177 135 adenosine A2a receptor "GO:0000139,GO:0001609,GO:0001973,GO:0005515,GO:0005882,GO:0005886,GO:0005887,GO:0006355,GO:0006469,GO:0006909,GO:0006915,GO:0006954,GO:0006968,GO:0007186,GO:0007188,GO:0007189,GO:0007205,GO:0007267,GO:0007271,GO:0007417,GO:0007596,GO:0007600,GO:0007626,GO:0008015,GO:0008285,GO:0014049,GO:0014057,GO:0014061,GO:0014069,GO:0016020,GO:0019899,GO:0030425,GO:0030673,GO:0031000,GO:0031802,GO:0035249,GO:0035810,GO:0035815,GO:0040013,GO:0042311,GO:0042493,GO:0042755,GO:0042802,GO:0043025,GO:0043116,GO:0043154,GO:0043524,GO:0044267,GO:0044877,GO:0045938,GO:0048143,GO:0048786,GO:0048812,GO:0050714,GO:0051393,GO:0051881,GO:0051899,GO:0051924,GO:0051968,GO:0060079,GO:0060134,GO:0098978,GO:0099055,GO:0099056,GO:1900273,GO:2000300" "Golgi membrane|G protein-coupled adenosine receptor activity|G protein-coupled adenosine receptor signaling pathway|protein binding|intermediate filament|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|negative regulation of protein kinase activity|phagocytosis|apoptotic process|inflammatory response|cellular defense response|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|cell-cell signaling|synaptic transmission, cholinergic|central nervous system development|blood coagulation|sensory perception|locomotory behavior|blood circulation|negative regulation of cell population proliferation|positive regulation of glutamate secretion|positive regulation of acetylcholine secretion, neurotransmission|regulation of norepinephrine secretion|postsynaptic density|membrane|enzyme binding|dendrite|axolemma|response to caffeine|type 5 metabotropic glutamate receptor binding|synaptic transmission, glutamatergic|positive regulation of urine volume|positive regulation of renal sodium excretion|negative regulation of locomotion|vasodilation|response to drug|eating behavior|identical protein binding|neuronal cell body|negative regulation of vascular permeability|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of neuron apoptotic process|cellular protein metabolic process|protein-containing complex binding|positive regulation of circadian sleep/wake cycle, sleep|astrocyte activation|presynaptic active zone|neuron projection morphogenesis|positive regulation of protein secretion|alpha-actinin binding|regulation of mitochondrial membrane potential|membrane depolarization|regulation of calcium ion transport|positive regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|prepulse inhibition|glutamatergic synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|positive regulation of long-term synaptic potentiation|regulation of synaptic vesicle exocytosis" "hsa04015,hsa04020,hsa04024,hsa04080,hsa04270,hsa05012,hsa05034" Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Parkinson disease|Alcoholism ADORA2B 1096.425851 1032.21022 1160.641483 1.124423553 0.169185579 0.626998373 1 9.011861096 10.56964383 136 adenosine A2b receptor "GO:0000187,GO:0001609,GO:0001973,GO:0005515,GO:0005886,GO:0005887,GO:0006968,GO:0007186,GO:0007190,GO:0007254,GO:0007588,GO:0044267" activation of MAPK activity|G protein-coupled adenosine receptor activity|G protein-coupled adenosine receptor signaling pathway|protein binding|plasma membrane|integral component of plasma membrane|cellular defense response|G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|JNK cascade|excretion|cellular protein metabolic process "hsa04015,hsa04020,hsa04080,hsa04270,hsa05034" Rap1 signaling pathway|Calcium signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Alcoholism ADPGK 1812.595308 1563.032191 2062.158424 1.319332024 0.399807679 0.218561851 1 15.15353492 20.8537416 83440 ADP dependent glucokinase "GO:0005576,GO:0005783,GO:0005789,GO:0006006,GO:0016020,GO:0043843,GO:0046872,GO:0061621" extracellular region|endoplasmic reticulum|endoplasmic reticulum membrane|glucose metabolic process|membrane|ADP-specific glucokinase activity|metal ion binding|canonical glycolysis hsa00010 Glycolysis / Gluconeogenesis ADPRH 50.15396738 60.8973581 39.41057666 0.64716398 -0.627796782 0.464410726 1 0.836062986 0.564376945 141 ADP-ribosylarginine hydrolase "GO:0000287,GO:0003875,GO:0005096,GO:0005515,GO:0005615,GO:0005776,GO:0005829,GO:0006464,GO:0006886,GO:0030955,GO:0051725,GO:0055037,GO:0090630,GO:2000785" magnesium ion binding|ADP-ribosylarginine hydrolase activity|GTPase activator activity|protein binding|extracellular space|autophagosome|cytosol|cellular protein modification process|intracellular protein transport|potassium ion binding|protein de-ADP-ribosylation|recycling endosome|activation of GTPase activity|regulation of autophagosome assembly ADPRHL1 33.65957209 44.65806261 22.66108158 0.507435394 -0.978703944 0.308700089 1 1.05052175 0.556034494 113622 ADP-ribosylhydrolase like 1 "GO:0000287,GO:0003875,GO:0051725" magnesium ion binding|ADP-ribosylarginine hydrolase activity|protein de-ADP-ribosylation ADPRM 114.7306024 97.43577296 132.0254318 1.354999584 0.438292408 0.502550382 1 3.21693492 4.546711171 56985 "ADP-ribose/CDP-alcohol diphosphatase, manganese dependent" "GO:0005829,GO:0008663,GO:0030145,GO:0034656,GO:0047631,GO:0047734" "cytosol|2',3'-cyclic-nucleotide 2'-phosphodiesterase activity|manganese ion binding|nucleobase-containing small molecule catabolic process|ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity" "hsa00230,hsa00564" Purine metabolism|Glycerophospholipid metabolism ADPRS 655.5593651 731.7832532 579.3354769 0.791676325 -0.337017386 0.379543507 1 22.35358275 18.45910872 54936 ADP-ribosylserine hydrolase "GO:0000287,GO:0004553,GO:0004649,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0006281,GO:0016604,GO:0061463,GO:0071451,GO:0090734,GO:0140290,GO:0140292" "magnesium ion binding|hydrolase activity, hydrolyzing O-glycosyl compounds|poly(ADP-ribose) glycohydrolase activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|DNA repair|nuclear body|O-acetyl-ADP-ribose deacetylase activity|cellular response to superoxide|site of DNA damage|peptidyl-serine ADP-deribosylation|ADP-ribosylserine hydrolase activity" ADRA1D 4.044978098 7.104691779 0.985264417 0.138677996 -2.850189203 0.227217187 1 0.122307129 0.017691932 146 adrenoceptor alpha 1D "GO:0001996,GO:0004930,GO:0004937,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0007188,GO:0007200,GO:0007204,GO:0007267,GO:0008284,GO:0042802,GO:0043410,GO:0045907,GO:0071880,GO:0150099" positive regulation of heart rate by epinephrine-norepinephrine|G protein-coupled receptor activity|alpha1-adrenergic receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|positive regulation of cell population proliferation|identical protein binding|positive regulation of MAPK cascade|positive regulation of vasoconstriction|adenylate cyclase-activating adrenergic receptor signaling pathway|neuron-glial cell signaling "hsa04020,hsa04022,hsa04080,hsa04261,hsa04270,hsa04970" Calcium signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion ADRB1 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.050744264 0.034254468 153 adrenoceptor beta 1 "GO:0001996,GO:0001997,GO:0002024,GO:0002025,GO:0004930,GO:0004939,GO:0004940,GO:0005085,GO:0005515,GO:0005769,GO:0005886,GO:0005887,GO:0007186,GO:0007190,GO:0009409,GO:0030165,GO:0031649,GO:0031694,GO:0040015,GO:0042596,GO:0043547,GO:0045187,GO:0046982,GO:0050873,GO:0060078,GO:0071880,GO:0098685,GO:0099579,GO:0120162" "positive regulation of heart rate by epinephrine-norepinephrine|positive regulation of the force of heart contraction by epinephrine-norepinephrine|diet induced thermogenesis|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure|G protein-coupled receptor activity|beta-adrenergic receptor activity|beta1-adrenergic receptor activity|guanyl-nucleotide exchange factor activity|protein binding|early endosome|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|response to cold|PDZ domain binding|heat generation|alpha-2A adrenergic receptor binding|negative regulation of multicellular organism growth|fear response|positive regulation of GTPase activity|regulation of circadian sleep/wake cycle, sleep|protein heterodimerization activity|brown fat cell differentiation|regulation of postsynaptic membrane potential|adenylate cyclase-activating adrenergic receptor signaling pathway|Schaffer collateral - CA1 synapse|G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential|positive regulation of cold-induced thermogenesis" "hsa04020,hsa04022,hsa04024,hsa04080,hsa04261,hsa04540,hsa04923,hsa04924,hsa04970,hsa05414" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Gap junction|Regulation of lipolysis in adipocytes|Renin secretion|Salivary secretion|Dilated cardiomyopathy ADRB2 84.53157993 87.28621328 81.77694657 0.936882739 -0.094059605 0.912000963 1 2.196094772 2.14611132 154 adrenoceptor beta 2 "GO:0001540,GO:0002024,GO:0002025,GO:0002028,GO:0002032,GO:0004930,GO:0004941,GO:0005515,GO:0005634,GO:0005764,GO:0005768,GO:0005769,GO:0005794,GO:0005886,GO:0005887,GO:0006898,GO:0007166,GO:0007171,GO:0007186,GO:0007188,GO:0007190,GO:0008179,GO:0008333,GO:0009409,GO:0010008,GO:0010739,GO:0015459,GO:0016020,GO:0016324,GO:0016579,GO:0030501,GO:0030665,GO:0031649,GO:0040015,GO:0042802,GO:0042803,GO:0043235,GO:0043410,GO:0044877,GO:0045453,GO:0045944,GO:0045986,GO:0050873,GO:0051380,GO:0061024,GO:0061885,GO:0071875,GO:0071880,GO:0071902,GO:0120162,GO:1901098,GO:1904504,GO:1904646,GO:1990911,GO:2000481,GO:2000969" amyloid-beta binding|diet induced thermogenesis|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure|regulation of sodium ion transport|desensitization of G protein-coupled receptor signaling pathway by arrestin|G protein-coupled receptor activity|beta2-adrenergic receptor activity|protein binding|nucleus|lysosome|endosome|early endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|cell surface receptor signaling pathway|activation of transmembrane receptor protein tyrosine kinase activity|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase binding|endosome to lysosome transport|response to cold|endosome membrane|positive regulation of protein kinase A signaling|potassium channel regulator activity|membrane|apical plasma membrane|protein deubiquitination|positive regulation of bone mineralization|clathrin-coated vesicle membrane|heat generation|negative regulation of multicellular organism growth|identical protein binding|protein homodimerization activity|receptor complex|positive regulation of MAPK cascade|protein-containing complex binding|bone resorption|positive regulation of transcription by RNA polymerase II|negative regulation of smooth muscle contraction|brown fat cell differentiation|norepinephrine binding|membrane organization|positive regulation of mini excitatory postsynaptic potential|adrenergic receptor signaling pathway|adenylate cyclase-activating adrenergic receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of cold-induced thermogenesis|positive regulation of autophagosome maturation|positive regulation of lipophagy|cellular response to amyloid-beta|response to psychosocial stress|positive regulation of cAMP-dependent protein kinase activity|positive regulation of AMPA receptor activity "hsa04020,hsa04022,hsa04024,hsa04080,hsa04261,hsa04923,hsa04924,hsa04970" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Regulation of lipolysis in adipocytes|Renin secretion|Salivary secretion ADRM1 3683.328642 4136.960527 3229.696757 0.780693153 -0.357172478 0.262004476 1 89.69283235 73.03886885 11047 adhesion regulating molecule 1 "GO:0000502,GO:0002020,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006368,GO:0006511,GO:0008541,GO:0010950,GO:0016579,GO:0043130,GO:0043248,GO:0061133,GO:0070628" "proteasome complex|protease binding|protein binding|nucleoplasm|cytosol|plasma membrane|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|proteasome regulatory particle, lid subcomplex|positive regulation of endopeptidase activity|protein deubiquitination|ubiquitin binding|proteasome assembly|endopeptidase activator activity|proteasome binding" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection ADSL 2052.321871 2190.27498 1914.368761 0.874031242 -0.194243245 0.546359905 1 27.62881716 25.18866665 158 adenylosuccinate lyase "GO:0004018,GO:0005829,GO:0006164,GO:0006167,GO:0006189,GO:0009168,GO:0032991,GO:0042802,GO:0044208,GO:0070626" "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity|cytosol|purine nucleotide biosynthetic process|AMP biosynthetic process|'de novo' IMP biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|protein-containing complex|identical protein binding|'de novo' AMP biosynthetic process|(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity" "hsa00230,hsa00250" "Purine metabolism|Alanine, aspartate and glutamate metabolism" ADSS1 16.10568351 23.34398727 8.867379749 0.379857119 -1.396471236 0.247723797 1 0.523137435 0.207277422 122622 adenylosuccinate synthase 1 "GO:0000287,GO:0002376,GO:0003924,GO:0004019,GO:0005525,GO:0005737,GO:0005829,GO:0006167,GO:0006531,GO:0006541,GO:0009168,GO:0014850,GO:0035690,GO:0042301,GO:0042594,GO:0042802,GO:0044208,GO:0046040,GO:0051015,GO:0071257" magnesium ion binding|immune system process|GTPase activity|adenylosuccinate synthase activity|GTP binding|cytoplasm|cytosol|AMP biosynthetic process|aspartate metabolic process|glutamine metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to muscle activity|cellular response to drug|phosphate ion binding|response to starvation|identical protein binding|'de novo' AMP biosynthetic process|IMP metabolic process|actin filament binding|cellular response to electrical stimulus "hsa00230,hsa00250" "Purine metabolism|Alanine, aspartate and glutamate metabolism" ADSS2 1007.97474 1047.434559 968.5149215 0.92465435 -0.11301393 0.749979971 1 14.22984584 13.72446873 159 adenylosuccinate synthase 2 "GO:0000287,GO:0002376,GO:0004019,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005829,GO:0006167,GO:0006531,GO:0009168,GO:0014074,GO:0042301,GO:0044208,GO:0046040,GO:0060359,GO:0070062,GO:0071257" magnesium ion binding|immune system process|adenylosuccinate synthase activity|protein binding|GTP binding|cytoplasm|mitochondrion|cytosol|AMP biosynthetic process|aspartate metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to purine-containing compound|phosphate ion binding|'de novo' AMP biosynthetic process|IMP metabolic process|response to ammonium ion|extracellular exosome|cellular response to electrical stimulus "hsa00230,hsa00250" "Purine metabolism|Alanine, aspartate and glutamate metabolism" ADTRP 37.21191798 51.76275439 22.66108158 0.437787398 -1.191697667 0.201201265 1 0.36996908 0.168944717 84830 androgen dependent TFPI regulating protein "GO:0001934,GO:0002042,GO:0002686,GO:0003332,GO:0005515,GO:0005901,GO:0009986,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0030195,GO:0042758,GO:0043491,GO:0050709,GO:0071383,GO:0140052,GO:1903038,GO:2000402" positive regulation of protein phosphorylation|cell migration involved in sprouting angiogenesis|negative regulation of leukocyte migration|negative regulation of extracellular matrix constituent secretion|protein binding|caveola|cell surface|positive regulation of gene expression|membrane|integral component of membrane|hydrolase activity|negative regulation of blood coagulation|long-chain fatty acid catabolic process|protein kinase B signaling|negative regulation of protein secretion|cellular response to steroid hormone stimulus|cellular response to oxidised low-density lipoprotein particle stimulus|negative regulation of leukocyte cell-cell adhesion|negative regulation of lymphocyte migration AEBP2 785.5736901 863.7275291 707.4198511 0.819031265 -0.288009569 0.435306828 1 7.917602226 6.764101094 121536 AE binding protein 2 "GO:0000122,GO:0000785,GO:0000978,GO:0001227,GO:0005654,GO:0006325,GO:0006357,GO:0035098,GO:0045814,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|ESC/E(Z) complex|negative regulation of gene expression, epigenetic|metal ion binding" other AEN 1092.349698 1225.051854 959.6475417 0.783352589 -0.35226628 0.310436089 1 12.71404809 10.38860091 64782 apoptosis enhancing nuclease "GO:0003676,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0010212,GO:0031965,GO:0042771,GO:0090305" nucleic acid binding|exonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|response to ionizing radiation|nuclear membrane|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|nucleic acid phosphodiester bond hydrolysis AFAP1 2871.952009 2991.075239 2752.82878 0.920347554 -0.119749321 0.707296264 1 16.90330383 16.22704312 60312 actin filament associated protein 1 "GO:0003779,GO:0005829,GO:0005925,GO:0009966,GO:0015629,GO:0017124,GO:0042169,GO:0051493" actin binding|cytosol|focal adhesion|regulation of signal transduction|actin cytoskeleton|SH3 domain binding|SH2 domain binding|regulation of cytoskeleton organization AFAP1L1 770.3575154 732.7982092 807.9168216 1.102509274 0.140790791 0.705812677 1 5.915467666 6.802793153 134265 actin filament associated protein 1 like 1 "GO:0002102,GO:0005515,GO:0005829,GO:0017124,GO:0030054,GO:0071437" podosome|protein binding|cytosol|SH3 domain binding|cell junction|invadopodium AFAP1L2 46.37893485 38.5683268 54.18954291 1.405027063 0.490597919 0.582316193 1 0.372563359 0.546010205 84632 actin filament associated protein 1 like 2 "GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007346,GO:0017124,GO:0030296,GO:0032675,GO:0032757,GO:0035591,GO:0042169,GO:0045742,GO:0045893,GO:0061098" "cytoplasm|cytosol|plasma membrane|inflammatory response|regulation of mitotic cell cycle|SH3 domain binding|protein tyrosine kinase activator activity|regulation of interleukin-6 production|positive regulation of interleukin-8 production|signaling adaptor activity|SH2 domain binding|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of protein tyrosine kinase activity" AFDN 1926.775132 1824.890831 2028.659434 1.111660708 0.152716528 0.637177796 1 10.88625239 12.62311632 4301 "afadin, adherens junction formation factor" "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0007155,GO:0007165,GO:0007267,GO:0008022,GO:0010628,GO:0016607,GO:0022409,GO:0030054,GO:0030336,GO:0031267,GO:0032880,GO:0034332,GO:0043547,GO:0044291,GO:0044331,GO:0045296,GO:0046930,GO:0046931,GO:0050839,GO:0051015,GO:0061951,GO:0070160,GO:0070830,GO:0090557,GO:2000049" protein binding|nucleoplasm|cytosol|plasma membrane|cell-cell junction|adherens junction|cell adhesion|signal transduction|cell-cell signaling|protein C-terminus binding|positive regulation of gene expression|nuclear speck|positive regulation of cell-cell adhesion|cell junction|negative regulation of cell migration|small GTPase binding|regulation of protein localization|adherens junction organization|positive regulation of GTPase activity|cell-cell contact zone|cell-cell adhesion mediated by cadherin|cadherin binding|pore complex|pore complex assembly|cell adhesion molecule binding|actin filament binding|establishment of protein localization to plasma membrane|tight junction|bicellular tight junction assembly|establishment of endothelial intestinal barrier|positive regulation of cell-cell adhesion mediated by cadherin "hsa04014,hsa04015,hsa04024,hsa04520,hsa04530,hsa04670" Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Adherens junction|Tight junction|Leukocyte transendothelial migration AFF1 1491.238526 1518.374129 1464.102923 0.964257027 -0.052510341 0.876071191 1 7.008776259 7.049380265 4299 AF4/FMR2 family member 1 "GO:0005515,GO:0008023,GO:0010468,GO:0032783" protein binding|transcription elongation factor complex|regulation of gene expression|super elongation complex hsa05202 Transcriptional misregulation in cancer AFF4 4489.381331 4481.0306 4497.732062 1.003727147 0.005367141 0.987387852 1 23.63061139 24.74039096 27125 AF4/FMR2 family member 4 "GO:0001650,GO:0005515,GO:0005654,GO:0006366,GO:0006368,GO:0007286,GO:0008023,GO:0010468,GO:0032783,GO:0035327" fibrillar center|protein binding|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|spermatid development|transcription elongation factor complex|regulation of gene expression|super elongation complex|transcriptionally active chromatin AF_4 AFG1L 77.63472901 87.28621328 67.98324474 0.778854325 -0.360574579 0.633194317 1 0.514518014 0.417996601 246269 AFG1 like ATPase "GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0006123,GO:0007005,GO:0016887,GO:0031966,GO:0035694" "protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial electron transport, cytochrome c to oxygen|mitochondrion organization|ATPase activity|mitochondrial membrane|mitochondrial protein catabolic process" AFG3L2 1699.808018 1800.531888 1599.084148 0.888117649 -0.171177291 0.601119084 1 28.85778108 26.73310259 10939 AFG3 like matrix AAA peptidase subunit 2 "GO:0004176,GO:0004222,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005745,GO:0006508,GO:0006851,GO:0007409,GO:0007528,GO:0008053,GO:0008237,GO:0008270,GO:0016485,GO:0016540,GO:0021675,GO:0033619,GO:0034982,GO:0036444,GO:0040014,GO:0042407,GO:0042552,GO:0048747,GO:0051082,GO:0051560,GO:0060013,GO:0065003" ATP-dependent peptidase activity|metalloendopeptidase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|m-AAA complex|proteolysis|mitochondrial calcium ion transmembrane transport|axonogenesis|neuromuscular junction development|mitochondrial fusion|metallopeptidase activity|zinc ion binding|protein processing|protein autoprocessing|nerve development|membrane protein proteolysis|mitochondrial protein processing|calcium import into the mitochondrion|regulation of multicellular organism growth|cristae formation|myelination|muscle fiber development|unfolded protein binding|mitochondrial calcium ion homeostasis|righting reflex|protein-containing complex assembly hsa05017 Spinocerebellar ataxia AFMID 229.3991001 224.305269 234.4929311 1.045418737 0.064080923 0.909486206 1 4.95432646 5.402450921 125061 arylformamidase "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016787,GO:0019441,GO:0034354" protein binding|nucleus|cytoplasm|cytosol|hydrolase activity|tryptophan catabolic process to kynurenine|'de novo' NAD biosynthetic process from tryptophan "hsa00380,hsa00630" Tryptophan metabolism|Glyoxylate and dicarboxylate metabolism AFTPH 552.8382498 546.046311 559.6301886 1.024876787 0.035450476 0.933833276 1 6.598739994 7.054213549 54812 aftiphilin "GO:0005654,GO:0005794,GO:0005829,GO:0015031,GO:0030121,GO:0030276,GO:0032588,GO:0043231,GO:0046907" nucleoplasm|Golgi apparatus|cytosol|protein transport|AP-1 adaptor complex|clathrin binding|trans-Golgi network membrane|intracellular membrane-bounded organelle|intracellular transport AGA 256.2805875 277.0829794 235.4781956 0.849847205 -0.234724614 0.640889213 1 6.889187734 6.106956125 175 aspartylglucosaminidase "GO:0003948,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005764,GO:0005783,GO:0006508,GO:0006517,GO:0008233,GO:0035578,GO:0043312,GO:0043621" N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity|protein binding|extracellular region|extracellular space|cytoplasm|lysosome|endoplasmic reticulum|proteolysis|protein deglycosylation|peptidase activity|azurophil granule lumen|neutrophil degranulation|protein self-association "hsa00511,hsa04142" Other glycan degradation|Lysosome AGAP1 1294.902445 1331.622231 1258.18266 0.944849546 -0.081843476 0.810543937 1 3.689183759 3.635874435 116987 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 1" "GO:0003924,GO:0005096,GO:0005515,GO:0005525,GO:0005543,GO:0005634,GO:0005737,GO:0015031,GO:0043547,GO:0046872" GTPase activity|GTPase activator activity|protein binding|GTP binding|phospholipid binding|nucleus|cytoplasm|protein transport|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis AGAP2 131.5543264 102.5105528 160.5980999 1.566649438 0.64768239 0.296387735 1 0.76507484 1.25023507 116986 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 2" "GO:0003924,GO:0005096,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0015031,GO:0016020,GO:0016197,GO:0019901,GO:0030036,GO:0030295,GO:0032147,GO:0035014,GO:0042177,GO:0043524,GO:0043547,GO:0045860,GO:0046872,GO:0061903,GO:0070062,GO:0090543" GTPase activity|GTPase activator activity|protein binding|ATP binding|GTP binding|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|protein transport|membrane|endosomal transport|protein kinase binding|actin cytoskeleton organization|protein kinase activator activity|activation of protein kinase activity|phosphatidylinositol 3-kinase regulator activity|negative regulation of protein catabolic process|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|positive regulation of protein kinase activity|metal ion binding|positive regulation of 1-phosphatidylinositol-3-kinase activity|extracellular exosome|Flemming body "hsa04068,hsa04144" FoxO signaling pathway|Endocytosis AGAP3 1410.94096 1316.397891 1505.484028 1.143639046 0.193631783 0.562949949 1 10.88326954 12.98267812 116988 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 3" "GO:0003924,GO:0005096,GO:0005525,GO:0005634,GO:0005737,GO:0007165,GO:0016020,GO:0031593,GO:0034614,GO:0043161,GO:0043547,GO:0046872,GO:0071944" GTPase activity|GTPase activator activity|GTP binding|nucleus|cytoplasm|signal transduction|membrane|polyubiquitin modification-dependent protein binding|cellular response to reactive oxygen species|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of GTPase activity|metal ion binding|cell periphery hsa04144 Endocytosis AGAP4 223.8613796 216.1856213 231.5371379 1.071010813 0.098973045 0.85667525 1 2.862493872 3.197822476 119016 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 4" "GO:0005096,GO:0005634,GO:0043547,GO:0046872" GTPase activator activity|nucleus|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis AGAP5 127.1030691 134.9891438 119.2169944 0.883159868 -0.179253479 0.784167294 1 2.514425862 2.316296178 729092 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 5" "GO:0005096,GO:0005634,GO:0043547,GO:0046872" GTPase activator activity|nucleus|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis AGAP6 246.0122616 248.6642123 243.3603109 0.978670427 -0.031104989 0.959506942 1 4.692237376 4.789965326 414189 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 6" "GO:0005096,GO:0005634,GO:0043547,GO:0046872" GTPase activator activity|nucleus|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis AGAP9 262.7441893 281.1428032 244.3455753 0.869115526 -0.202380137 0.686137031 1 5.965182728 5.407757268 642517 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 9" "GO:0005096,GO:0005634,GO:0043547,GO:0046872" GTPase activator activity|nucleus|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis AGBL2 33.04817368 36.53841486 29.5579325 0.808954975 -0.305868687 0.773258009 1 0.362353987 0.305754829 79841 AGBL carboxypeptidase 2 "GO:0004181,GO:0005814,GO:0005829,GO:0006508,GO:0008270,GO:0035610,GO:0036064" metallocarboxypeptidase activity|centriole|cytosol|proteolysis|zinc ion binding|protein side chain deglutamylation|ciliary basal body AGBL3 37.3927889 30.44867905 44.33689874 1.456118956 0.542128219 0.569704215 1 0.189775803 0.288239585 340351 AGBL carboxypeptidase 3 "GO:0004181,GO:0005829,GO:0006508,GO:0008270,GO:0035610" metallocarboxypeptidase activity|cytosol|proteolysis|zinc ion binding|protein side chain deglutamylation AGBL5 846.2971043 737.872989 954.7212196 1.293882869 0.37170702 0.306499746 1 11.42833756 15.42389117 60509 AGBL carboxypeptidase 5 "GO:0004181,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008270,GO:0015630,GO:0015631,GO:0030496,GO:0035608,GO:0035611,GO:0045171,GO:0051607,GO:0072686" metallocarboxypeptidase activity|nucleus|cytoplasm|cytosol|proteolysis|zinc ion binding|microtubule cytoskeleton|tubulin binding|midbody|protein deglutamylation|protein branching point deglutamylation|intercellular bridge|defense response to virus|mitotic spindle AGER 31.5405855 34.50850292 28.57266808 0.82798921 -0.272316127 0.805571575 1 1.024463033 0.884783263 177 advanced glycosylation end-product specific receptor "GO:0001540,GO:0001650,GO:0001666,GO:0001774,GO:0001914,GO:0001934,GO:0004888,GO:0005044,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006897,GO:0006954,GO:0007166,GO:0007611,GO:0009611,GO:0009986,GO:0010255,GO:0016324,GO:0030054,GO:0031175,GO:0032693,GO:0032722,GO:0032731,GO:0032735,GO:0032755,GO:0032760,GO:0034116,GO:0038023,GO:0042104,GO:0042802,GO:0043507,GO:0044548,GO:0044877,GO:0045056,GO:0045087,GO:0046330,GO:0048143,GO:0048167,GO:0050727,GO:0050785,GO:0050930,GO:0051092,GO:0051101,GO:0070374,GO:0071639,GO:0072657,GO:0090647,GO:0098794,GO:0150003,GO:0150104,GO:1900271,GO:1900272,GO:1900453,GO:1900744,GO:1900745,GO:1901222,GO:1901224,GO:1902961,GO:1903523,GO:1904472,GO:1904597,GO:1904645,GO:1904646,GO:2000439,GO:2000514,GO:2001200" "amyloid-beta binding|fibrillar center|response to hypoxia|microglial cell activation|regulation of T cell mediated cytotoxicity|positive regulation of protein phosphorylation|transmembrane signaling receptor activity|scavenger receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|endocytosis|inflammatory response|cell surface receptor signaling pathway|learning or memory|response to wounding|cell surface|glucose mediated signaling pathway|apical plasma membrane|cell junction|neuron projection development|negative regulation of interleukin-10 production|positive regulation of chemokine production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of heterotypic cell-cell adhesion|signaling receptor activity|positive regulation of activated T cell proliferation|identical protein binding|positive regulation of JUN kinase activity|S100 protein binding|protein-containing complex binding|transcytosis|innate immune response|positive regulation of JNK cascade|astrocyte activation|regulation of synaptic plasticity|regulation of inflammatory response|advanced glycation end-product receptor activity|induction of positive chemotaxis|positive regulation of NF-kappaB transcription factor activity|regulation of DNA binding|positive regulation of ERK1 and ERK2 cascade|positive regulation of monocyte chemotactic protein-1 production|protein localization to membrane|modulation of age-related behavioral decline|postsynapse|regulation of spontaneous synaptic transmission|transport across blood-brain barrier|regulation of long-term synaptic potentiation|negative regulation of long-term synaptic potentiation|negative regulation of long-term synaptic depression|regulation of p38MAPK cascade|positive regulation of p38MAPK cascade|regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of blood circulation|positive regulation of endothelin production|negative regulation of connective tissue replacement involved in inflammatory response wound healing|response to amyloid-beta|cellular response to amyloid-beta|positive regulation of monocyte extravasation|regulation of CD4-positive, alpha-beta T cell activation|positive regulation of dendritic cell differentiation" "hsa04933,hsa05010,hsa05022" AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Pathways of neurodegeneration - multiple diseases AGFG1 1442.080709 1323.502583 1560.658836 1.179188357 0.237794185 0.475833585 1 7.661531236 9.423553242 3267 ArfGAP with FG repeats 1 "GO:0003677,GO:0003723,GO:0005096,GO:0005515,GO:0005643,GO:0005829,GO:0006406,GO:0007275,GO:0007283,GO:0030154,GO:0031410,GO:0043231,GO:0043547,GO:0046872,GO:0061024" DNA binding|RNA binding|GTPase activator activity|protein binding|nuclear pore|cytosol|mRNA export from nucleus|multicellular organism development|spermatogenesis|cell differentiation|cytoplasmic vesicle|intracellular membrane-bounded organelle|positive regulation of GTPase activity|metal ion binding|membrane organization AGFG2 158.9284459 155.2882632 162.5686287 1.046882909 0.06610009 0.920432461 1 1.527146156 1.667610585 3268 ArfGAP with FG repeats 2 "GO:0003674,GO:0005096,GO:0008150,GO:0016020,GO:0043547,GO:0046872" molecular_function|GTPase activator activity|biological_process|membrane|positive regulation of GTPase activity|metal ion binding AGGF1 1172.045514 1116.451565 1227.639463 1.099590436 0.136966263 0.691292506 1 12.59339269 14.44407149 55109 angiogenic factor with G-patch and FHA domains 1 "GO:0001525,GO:0001570,GO:0001938,GO:0003676,GO:0005515,GO:0005576,GO:0005737,GO:0007155,GO:0045766,GO:0048471" angiogenesis|vasculogenesis|positive regulation of endothelial cell proliferation|nucleic acid binding|protein binding|extracellular region|cytoplasm|cell adhesion|positive regulation of angiogenesis|perinuclear region of cytoplasm AGK 747.7976326 773.3964479 722.1988173 0.93380157 -0.098812081 0.793526872 1 3.415573919 3.326857647 55750 acylglycerol kinase "GO:0001727,GO:0001729,GO:0003951,GO:0004143,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005829,GO:0006665,GO:0016020,GO:0016310,GO:0017050,GO:0031305,GO:0031966,GO:0042721,GO:0043231,GO:0045039,GO:0046474,GO:0046512,GO:0046513,GO:0046834,GO:0047620,GO:0102773" lipid kinase activity|ceramide kinase activity|NAD+ kinase activity|diacylglycerol kinase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|sphingolipid metabolic process|membrane|phosphorylation|D-erythro-sphingosine kinase activity|integral component of mitochondrial inner membrane|mitochondrial membrane|TIM22 mitochondrial import inner membrane insertion complex|intracellular membrane-bounded organelle|protein insertion into mitochondrial inner membrane|glycerophospholipid biosynthetic process|sphingosine biosynthetic process|ceramide biosynthetic process|lipid phosphorylation|acylglycerol kinase activity|dihydroceramide kinase activity hsa00561 Glycerolipid metabolism AGL 739.9452088 775.4263598 704.4640578 0.908486085 -0.138463678 0.712898684 1 5.765209863 5.463228061 178 "amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase" "GO:0004133,GO:0004134,GO:0004135,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005978,GO:0005980,GO:0007584,GO:0016234,GO:0016529,GO:0030247,GO:0031593,GO:0034774,GO:0043033,GO:0043312,GO:0051384,GO:0102500,GO:1904813" "glycogen debranching enzyme activity|4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|protein binding|extracellular region|nucleus|cytoplasm|cytosol|glycogen biosynthetic process|glycogen catabolic process|response to nutrient|inclusion body|sarcoplasmic reticulum|polysaccharide binding|polyubiquitin modification-dependent protein binding|secretory granule lumen|isoamylase complex|neutrophil degranulation|response to glucocorticoid|beta-maltose 4-alpha-glucanotransferase activity|ficolin-1-rich granule lumen" hsa00500 Starch and sucrose metabolism AGMAT 23.53970396 26.38885518 20.69055275 0.784064053 -0.350956577 0.770075428 1 0.431826307 0.353164116 79814 agmatinase "GO:0005739,GO:0008295,GO:0008783,GO:0033389,GO:0046872,GO:0097055" "mitochondrion|spermidine biosynthetic process|agmatinase activity|putrescine biosynthetic process from arginine, using agmatinase|metal ion binding|agmatine biosynthetic process" hsa00330 Arginine and proline metabolism AGO1 892.4424661 895.1911641 889.6937681 0.99385897 -0.008886949 0.98378303 1 3.468350246 3.59553598 26523 argonaute RISC component 1 "GO:0000932,GO:0000956,GO:0000993,GO:0001046,GO:0003723,GO:0003725,GO:0003727,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0007223,GO:0010501,GO:0010628,GO:0010629,GO:0016442,GO:0016525,GO:0031054,GO:0035194,GO:0035196,GO:0035198,GO:0035278,GO:0035279,GO:0035280,GO:0036464,GO:0045652,GO:0045944,GO:0060964,GO:0070578,GO:0090502,GO:0090625,GO:1990904" "P-body|nuclear-transcribed mRNA catabolic process|RNA polymerase II complex binding|core promoter sequence-specific DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|endoribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|polysome|Wnt signaling pathway, calcium modulating pathway|RNA secondary structure unwinding|positive regulation of gene expression|negative regulation of gene expression|RISC complex|negative regulation of angiogenesis|pre-miRNA processing|post-transcriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|mRNA cleavage involved in gene silencing by miRNA|miRNA loading onto RISC involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|regulation of gene silencing by miRNA|RISC-loading complex|RNA phosphodiester bond hydrolysis, endonucleolytic|mRNA cleavage involved in gene silencing by siRNA|ribonucleoprotein complex" AGO2 3963.234541 3570.615097 4355.853986 1.21991698 0.28678297 0.368273688 1 9.651441441 12.28113162 27161 argonaute RISC catalytic component 2 "GO:0000340,GO:0000932,GO:0000993,GO:0001046,GO:0003723,GO:0003725,GO:0003727,GO:0003743,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0005845,GO:0006412,GO:0006413,GO:0007223,GO:0008022,GO:0009791,GO:0010501,GO:0010586,GO:0010628,GO:0010629,GO:0016020,GO:0016442,GO:0030422,GO:0030425,GO:0031047,GO:0031054,GO:0035087,GO:0035194,GO:0035196,GO:0035197,GO:0035198,GO:0035278,GO:0035279,GO:0035280,GO:0036464,GO:0042985,GO:0045766,GO:0045944,GO:0045947,GO:0045975,GO:0046872,GO:0060213,GO:0060964,GO:0070062,GO:0070551,GO:0070578,GO:0090502,GO:0090624,GO:0090625,GO:0098808,GO:1900153,GO:1901165,GO:1905618,GO:1990904" "RNA 7-methylguanosine cap binding|P-body|RNA polymerase II complex binding|core promoter sequence-specific DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|translation initiation factor activity|endoribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|polysome|mRNA cap binding complex|translation|translational initiation|Wnt signaling pathway, calcium modulating pathway|protein C-terminus binding|post-embryonic development|RNA secondary structure unwinding|miRNA metabolic process|positive regulation of gene expression|negative regulation of gene expression|membrane|RISC complex|production of siRNA involved in RNA interference|dendrite|gene silencing by RNA|pre-miRNA processing|siRNA loading onto RISC involved in RNA interference|post-transcriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|siRNA binding|miRNA binding|miRNA mediated inhibition of translation|mRNA cleavage involved in gene silencing by miRNA|miRNA loading onto RISC involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|negative regulation of amyloid precursor protein biosynthetic process|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|negative regulation of translational initiation|positive regulation of translation, ncRNA-mediated|metal ion binding|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of gene silencing by miRNA|extracellular exosome|endoribonuclease activity, cleaving siRNA-paired mRNA|RISC-loading complex|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity, cleaving miRNA-paired mRNA|mRNA cleavage involved in gene silencing by siRNA|mRNA cap binding|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of trophoblast cell migration|positive regulation of miRNA mediated inhibition of translation|ribonucleoprotein complex" AGO3 273.5969436 282.1577592 265.0361281 0.939318943 -0.090312991 0.859634326 1 1.196140881 1.171956101 192669 argonaute RISC catalytic component 3 "GO:0000794,GO:0000932,GO:0003723,GO:0003725,GO:0003727,GO:0004521,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006402,GO:0007223,GO:0010501,GO:0010628,GO:0010629,GO:0016020,GO:0016442,GO:0031054,GO:0035194,GO:0035196,GO:0035198,GO:0035278,GO:0035279,GO:0035280,GO:0036464,GO:0045652,GO:0046872,GO:0070578,GO:0072091,GO:0090502,GO:0090624,GO:0090625,GO:1901224" "condensed nuclear chromosome|P-body|RNA binding|double-stranded RNA binding|single-stranded RNA binding|endoribonuclease activity|protein binding|nucleoplasm|cytoplasm|cytosol|mRNA catabolic process|Wnt signaling pathway, calcium modulating pathway|RNA secondary structure unwinding|positive regulation of gene expression|negative regulation of gene expression|membrane|RISC complex|pre-miRNA processing|post-transcriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|mRNA cleavage involved in gene silencing by miRNA|miRNA loading onto RISC involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|regulation of megakaryocyte differentiation|metal ion binding|RISC-loading complex|regulation of stem cell proliferation|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity, cleaving miRNA-paired mRNA|mRNA cleavage involved in gene silencing by siRNA|positive regulation of NIK/NF-kappaB signaling" AGO4 693.2208618 578.524902 807.9168216 1.396511747 0.481827709 0.20321227 1 4.152529106 6.048855476 192670 argonaute RISC component 4 "GO:0000932,GO:0003725,GO:0003727,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006402,GO:0007130,GO:0007140,GO:0007223,GO:0008584,GO:0010501,GO:0010586,GO:0010628,GO:0010629,GO:0016020,GO:0016442,GO:0022604,GO:0031054,GO:0035194,GO:0035196,GO:0035198,GO:0035278,GO:0035279,GO:0035280,GO:0036464,GO:0043066,GO:0045652,GO:0070578,GO:0090625" "P-body|double-stranded RNA binding|single-stranded RNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA catabolic process|synaptonemal complex assembly|male meiotic nuclear division|Wnt signaling pathway, calcium modulating pathway|male gonad development|RNA secondary structure unwinding|miRNA metabolic process|positive regulation of gene expression|negative regulation of gene expression|membrane|RISC complex|regulation of cell morphogenesis|pre-miRNA processing|post-transcriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|mRNA cleavage involved in gene silencing by miRNA|miRNA loading onto RISC involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|negative regulation of apoptotic process|regulation of megakaryocyte differentiation|RISC-loading complex|mRNA cleavage involved in gene silencing by siRNA" AGPAT1 1378.764727 1204.752734 1552.77672 1.288875863 0.366113319 0.274874103 1 19.02602928 25.57850639 10554 1-acylglycerol-3-phosphate O-acyltransferase 1 "GO:0001819,GO:0001961,GO:0003841,GO:0005515,GO:0005783,GO:0005789,GO:0006644,GO:0006654,GO:0016020,GO:0016021,GO:0016024,GO:0031325" positive regulation of cytokine production|positive regulation of cytokine-mediated signaling pathway|1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|positive regulation of cellular metabolic process "hsa00561,hsa00564,hsa04072,hsa04975" Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway|Fat digestion and absorption AGPAT2 1190.085354 1036.270044 1343.900664 1.296863373 0.375026497 0.273660738 1 33.94787967 45.922213 10555 1-acylglycerol-3-phosphate O-acyltransferase 2 "GO:0001819,GO:0001961,GO:0003841,GO:0005783,GO:0005789,GO:0005886,GO:0006644,GO:0006654,GO:0008544,GO:0016021,GO:0016024,GO:0035579,GO:0042493,GO:0043312" positive regulation of cytokine production|positive regulation of cytokine-mediated signaling pathway|1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|epidermis development|integral component of membrane|CDP-diacylglycerol biosynthetic process|specific granule membrane|response to drug|neutrophil degranulation "hsa00561,hsa00564,hsa04072,hsa04975" Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway|Fat digestion and absorption AGPAT3 3499.824256 3480.284016 3519.364496 1.011229107 0.016109895 0.960566339 1 20.24395402 21.35309507 56894 1-acylglycerol-3-phosphate O-acyltransferase 3 "GO:0000139,GO:0003841,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005886,GO:0006654,GO:0008654,GO:0012505,GO:0016020,GO:0016021,GO:0016024,GO:0016746" "Golgi membrane|1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|endomembrane system|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|transferase activity, transferring acyl groups" "hsa00561,hsa00564,hsa04072" Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway AGPAT4 326.5258333 364.3691926 288.682474 0.792280137 -0.335917461 0.467329526 1 2.289579924 1.892127973 56895 1-acylglycerol-3-phosphate O-acyltransferase 4 "GO:0003841,GO:0005515,GO:0005741,GO:0005783,GO:0005789,GO:0006654,GO:0008654,GO:0012505,GO:0016021,GO:0016024,GO:0016746" "1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|endomembrane system|integral component of membrane|CDP-diacylglycerol biosynthetic process|transferase activity, transferring acyl groups" "hsa00561,hsa00564,hsa04072" Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway AGPAT5 868.9012783 1070.778547 667.02401 0.62293367 -0.682849541 0.05938649 1 10.24776189 6.658658792 55326 1-acylglycerol-3-phosphate O-acyltransferase 5 "GO:0002244,GO:0003841,GO:0005515,GO:0005635,GO:0005739,GO:0005741,GO:0005789,GO:0006639,GO:0006654,GO:0008654,GO:0012505,GO:0016021,GO:0016024,GO:0016746" "hematopoietic progenitor cell differentiation|1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|nuclear envelope|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum membrane|acylglycerol metabolic process|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|endomembrane system|integral component of membrane|CDP-diacylglycerol biosynthetic process|transferase activity, transferring acyl groups" "hsa00561,hsa00564,hsa04072" Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway AGPS 1305.544637 1351.92135 1259.167924 0.931391404 -0.102540527 0.762997334 1 7.472448661 7.259573308 8540 alkylglycerone phosphate synthase "GO:0005515,GO:0005730,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006625,GO:0008609,GO:0008610,GO:0008611,GO:0016020,GO:0016491,GO:0055114,GO:0071949" protein binding|nucleolus|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|protein targeting to peroxisome|alkylglycerone-phosphate synthase activity|lipid biosynthetic process|ether lipid biosynthetic process|membrane|oxidoreductase activity|oxidation-reduction process|FAD binding "hsa00565,hsa04146" Ether lipid metabolism|Peroxisome AGRN 19240.15899 23637.30955 14843.00844 0.627948304 -0.671282302 0.064535796 1 147.3048285 96.48433416 375790 agrin "GO:0001523,GO:0002162,GO:0005200,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0007010,GO:0007165,GO:0007213,GO:0007528,GO:0009887,GO:0009888,GO:0016021,GO:0030198,GO:0033691,GO:0035374,GO:0043113,GO:0043202,GO:0043236,GO:0043395,GO:0043547,GO:0045162,GO:0045202,GO:0045887,GO:0045944,GO:0050808,GO:0051491,GO:0062023,GO:0070062" retinoid metabolic process|dystroglycan binding|structural constituent of cytoskeleton|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|basement membrane|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cytoskeleton organization|signal transduction|G protein-coupled acetylcholine receptor signaling pathway|neuromuscular junction development|animal organ morphogenesis|tissue development|integral component of membrane|extracellular matrix organization|sialic acid binding|chondroitin sulfate binding|receptor clustering|lysosomal lumen|laminin binding|heparan sulfate proteoglycan binding|positive regulation of GTPase activity|clustering of voltage-gated sodium channels|synapse|positive regulation of synaptic growth at neuromuscular junction|positive regulation of transcription by RNA polymerase II|synapse organization|positive regulation of filopodium assembly|collagen-containing extracellular matrix|extracellular exosome hsa04512 ECM-receptor interaction AGTPBP1 672.0807303 783.5460076 560.615453 0.715485048 -0.483006476 0.20510589 1 3.270466549 2.44076633 23287 ATP/GTP binding carboxypeptidase 1 "GO:0001754,GO:0004181,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006508,GO:0007005,GO:0008270,GO:0015631,GO:0021702,GO:0021772,GO:0035608,GO:0035609,GO:0035610,GO:0043231,GO:0050905" eye photoreceptor cell differentiation|metallocarboxypeptidase activity|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|proteolysis|mitochondrion organization|zinc ion binding|tubulin binding|cerebellar Purkinje cell differentiation|olfactory bulb development|protein deglutamylation|C-terminal protein deglutamylation|protein side chain deglutamylation|intracellular membrane-bounded organelle|neuromuscular process AGTRAP 1165.202603 1187.498483 1142.906723 0.962448996 -0.055218006 0.874604306 1 47.8461487 48.03310255 57085 angiotensin II receptor associated protein "GO:0000139,GO:0001666,GO:0004945,GO:0005515,GO:0005789,GO:0005794,GO:0005886,GO:0005938,GO:0008217,GO:0016021,GO:0030659,GO:0038166,GO:0043231" Golgi membrane|response to hypoxia|angiotensin type II receptor activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|cell cortex|regulation of blood pressure|integral component of membrane|cytoplasmic vesicle membrane|angiotensin-activated signaling pathway|intracellular membrane-bounded organelle AGXT2 12.12008852 20.29911937 3.941057666 0.194149194 -2.364762376 0.086240025 1 0.462681721 0.093698765 64902 alanine--glyoxylate aminotransferase 2 "GO:0005739,GO:0005759,GO:0008453,GO:0009436,GO:0019265,GO:0019481,GO:0030170,GO:0045429,GO:0046487,GO:0047305" "mitochondrion|mitochondrial matrix|alanine-glyoxylate transaminase activity|glyoxylate catabolic process|glycine biosynthetic process, by transamination of glyoxylate|L-alanine catabolic process, by transamination|pyridoxal phosphate binding|positive regulation of nitric oxide biosynthetic process|glyoxylate metabolic process|(R)-3-amino-2-methylpropionate-pyruvate transaminase activity" "hsa00250,hsa00260,hsa00270,hsa00280" "Alanine, aspartate and glutamate metabolism|Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation" AHCTF1 2566.769943 2671.364109 2462.175777 0.921692318 -0.117642869 0.712820502 1 14.97621963 14.39806394 25909 AT-hook containing transcription factor 1 "GO:0000777,GO:0000785,GO:0003677,GO:0005634,GO:0005643,GO:0005654,GO:0005829,GO:0007049,GO:0015031,GO:0016363,GO:0031080,GO:0031965,GO:0032465,GO:0051028,GO:0051292,GO:0051301,GO:0070062" condensed chromosome kinetochore|chromatin|DNA binding|nucleus|nuclear pore|nucleoplasm|cytosol|cell cycle|protein transport|nuclear matrix|nuclear pore outer ring|nuclear membrane|regulation of cytokinesis|mRNA transport|nuclear pore complex assembly|cell division|extracellular exosome AHCY 8053.707993 7992.778251 8114.637735 1.015246198 0.021829625 0.947749713 1 91.66803025 97.07450867 191 adenosylhomocysteinase "GO:0000096,GO:0001666,GO:0002439,GO:0004013,GO:0005515,GO:0005634,GO:0005829,GO:0006730,GO:0007584,GO:0019510,GO:0030554,GO:0032259,GO:0033353,GO:0042470,GO:0042745,GO:0042802,GO:0043005,GO:0051287,GO:0070062" sulfur amino acid metabolic process|response to hypoxia|chronic inflammatory response to antigenic stimulus|adenosylhomocysteinase activity|protein binding|nucleus|cytosol|one-carbon metabolic process|response to nutrient|S-adenosylhomocysteine catabolic process|adenyl nucleotide binding|methylation|S-adenosylmethionine cycle|melanosome|circadian sleep/wake cycle|identical protein binding|neuron projection|NAD binding|extracellular exosome hsa00270 Cysteine and methionine metabolism AHCYL1 3544.163876 3446.790469 3641.537284 1.056500915 0.079294017 0.803802963 1 38.06536801 41.94844245 10768 adenosylhomocysteinase like 1 "GO:0003723,GO:0004013,GO:0005515,GO:0005737,GO:0005789,GO:0005829,GO:0006378,GO:0006611,GO:0006730,GO:0006915,GO:0010765,GO:0016324,GO:0031440,GO:0032412,GO:0033353,GO:0038166,GO:0042045,GO:0042802,GO:0044070,GO:0044233,GO:0051592,GO:0070062,GO:1903779,GO:1990456" RNA binding|adenosylhomocysteinase activity|protein binding|cytoplasm|endoplasmic reticulum membrane|cytosol|mRNA polyadenylation|protein export from nucleus|one-carbon metabolic process|apoptotic process|positive regulation of sodium ion transport|apical plasma membrane|regulation of mRNA 3'-end processing|regulation of ion transmembrane transporter activity|S-adenosylmethionine cycle|angiotensin-activated signaling pathway|epithelial fluid transport|identical protein binding|regulation of anion transport|mitochondria-associated endoplasmic reticulum membrane|response to calcium ion|extracellular exosome|regulation of cardiac conduction|mitochondrion-endoplasmic reticulum membrane tethering hsa00270 Cysteine and methionine metabolism AHCYL2 616.0436302 556.1958707 675.8913898 1.215203897 0.281198402 0.470241065 1 3.669318576 4.651044588 23382 adenosylhomocysteinase like 2 "GO:0004013,GO:0005515,GO:0005783,GO:0005829,GO:0006730,GO:0033353,GO:0043005" adenosylhomocysteinase activity|protein binding|endoplasmic reticulum|cytosol|one-carbon metabolic process|S-adenosylmethionine cycle|neuron projection hsa00270 Cysteine and methionine metabolism AHDC1 458.9169664 456.7301858 461.1037469 1.009575809 0.013749247 0.97956773 1 2.860011457 3.011775793 27245 AT-hook DNA binding motif containing 1 "GO:0003677,GO:0005515" DNA binding|protein binding AHI1 210.8451013 201.9762377 219.7139649 1.087820861 0.121440998 0.826271933 1 1.357402324 1.540216959 54806 Abelson helper integration site 1 "GO:0001738,GO:0001947,GO:0002092,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005911,GO:0005912,GO:0005929,GO:0007169,GO:0007417,GO:0010842,GO:0016192,GO:0030862,GO:0030902,GO:0034613,GO:0035844,GO:0035845,GO:0036038,GO:0036064,GO:0039008,GO:0039023,GO:0042802,GO:0043066,GO:0045944,GO:0050795,GO:0060271,GO:0065001,GO:0070121,GO:0070986,GO:0071599,GO:0097711,GO:0097730" morphogenesis of a polarized epithelium|heart looping|positive regulation of receptor internalization|protein binding|centrosome|centriole|cytosol|cell-cell junction|adherens junction|cilium|transmembrane receptor protein tyrosine kinase signaling pathway|central nervous system development|retina layer formation|vesicle-mediated transport|positive regulation of polarized epithelial cell differentiation|hindbrain development|cellular protein localization|cloaca development|photoreceptor cell outer segment organization|MKS complex|ciliary basal body|pronephric nephron tubule morphogenesis|pronephric duct morphogenesis|identical protein binding|negative regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|regulation of behavior|cilium assembly|specification of axis polarity|Kupffer's vesicle development|left/right axis specification|otic vesicle development|ciliary basal body-plasma membrane docking|non-motile cilium AHNAK 48101.05138 42870.72515 53331.3776 1.244004561 0.314991775 0.457957436 1 111.9952025 145.3239927 79026 AHNAK nucleoprotein "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0005925,GO:0015629,GO:0016020,GO:0030315,GO:0031982,GO:0042383,GO:0043034,GO:0043484,GO:0044291,GO:0044548,GO:0045121,GO:0045296,GO:0070062,GO:0097493,GO:1901385" RNA binding|protein binding|nucleus|cytoplasm|lysosomal membrane|cytosol|plasma membrane|focal adhesion|actin cytoskeleton|membrane|T-tubule|vesicle|sarcolemma|costamere|regulation of RNA splicing|cell-cell contact zone|S100 protein binding|membrane raft|cadherin binding|extracellular exosome|structural molecule activity conferring elasticity|regulation of voltage-gated calcium channel activity hsa05132 Salmonella infection AHNAK2 6975.505581 8846.35622 5104.654942 0.577034749 -0.793269894 0.015965579 0.5587138 24.1022505 14.50692924 113146 AHNAK nucleoprotein 2 "GO:0001778,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0030018,GO:0030315,GO:0030659,GO:0042383,GO:0043034,GO:0043484" plasma membrane repair|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|Z disc|T-tubule|cytoplasmic vesicle membrane|sarcolemma|costamere|regulation of RNA splicing hsa05132 Salmonella infection AHR 447.3731415 509.5078961 385.2383869 0.756098953 -0.403353038 0.337919437 1 4.133393801 3.259878025 196 aryl hydrocarbon receptor "GO:0000785,GO:0000976,GO:0000981,GO:0000987,GO:0001094,GO:0001223,GO:0001568,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006805,GO:0006915,GO:0007049,GO:0008134,GO:0009410,GO:0009636,GO:0010468,GO:0017025,GO:0019933,GO:0030522,GO:0030888,GO:0032922,GO:0032991,GO:0034751,GO:0034752,GO:0042803,GO:0045892,GO:0045893,GO:0046982,GO:0051879,GO:0070888,GO:0071320,GO:1904322,GO:1904613,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|TFIID-class transcription factor complex binding|transcription coactivator binding|blood vessel development|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|xenobiotic metabolic process|apoptotic process|cell cycle|transcription factor binding|response to xenobiotic stimulus|response to toxic substance|regulation of gene expression|TBP-class protein binding|cAMP-mediated signaling|intracellular receptor signaling pathway|regulation of B cell proliferation|circadian regulation of gene expression|protein-containing complex|aryl hydrocarbon receptor complex|cytosolic aryl hydrocarbon receptor complex|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein heterodimerization activity|Hsp90 protein binding|E-box binding|cellular response to cAMP|cellular response to forskolin|cellular response to 2,3,7,8-tetrachlorodibenzodioxine|sequence-specific double-stranded DNA binding" "hsa04659,hsa04934" Th17 cell differentiation|Cushing syndrome bHLH AHRR 160.6196266 102.5105528 218.7287005 2.133718866 1.093370102 0.060540646 1 0.908610057 2.022230547 57491 aryl-hydrocarbon receptor repressor "GO:0000785,GO:0000976,GO:0000981,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006805,GO:0030522,GO:0034751,GO:0046983" "chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|xenobiotic metabolic process|intracellular receptor signaling pathway|aryl hydrocarbon receptor complex|protein dimerization activity" bHLH AHSA1 2457.095315 2448.073796 2466.116835 1.0073703 0.010594103 0.974923721 1 85.33124671 89.66297884 10598 activator of HSP90 ATPase activity 1 "GO:0001671,GO:0005515,GO:0005783,GO:0005829,GO:0006457,GO:0016032,GO:0032781,GO:0045296,GO:0051087,GO:0051879,GO:0070062" ATPase activator activity|protein binding|endoplasmic reticulum|cytosol|protein folding|viral process|positive regulation of ATPase activity|cadherin binding|chaperone binding|Hsp90 protein binding|extracellular exosome AIDA 1262.965229 1034.240132 1491.690327 1.442305593 0.528376873 0.119881105 1 17.60692911 26.48846751 64853 "axin interactor, dorsalization associated" "GO:0005515,GO:0005575,GO:0005737,GO:0009953,GO:0016020,GO:0019904,GO:0031333,GO:0035091,GO:0043508,GO:0046329,GO:0048264" protein binding|cellular_component|cytoplasm|dorsal/ventral pattern formation|membrane|protein domain specific binding|negative regulation of protein-containing complex assembly|phosphatidylinositol binding|negative regulation of JUN kinase activity|negative regulation of JNK cascade|determination of ventral identity AIF1L 79.51890479 47.70293051 111.3348791 2.333921163 1.222755829 0.096768927 1 0.66501105 1.61894082 83543 allograft inflammatory factor 1 like "GO:0005509,GO:0005737,GO:0005884,GO:0005925,GO:0015629,GO:0032587,GO:0032991,GO:0051015,GO:0051017,GO:0070062,GO:0097178" calcium ion binding|cytoplasm|actin filament|focal adhesion|actin cytoskeleton|ruffle membrane|protein-containing complex|actin filament binding|actin filament bundle assembly|extracellular exosome|ruffle assembly AIFM1 1225.22802 1384.399941 1066.056099 0.770049223 -0.376977426 0.269000404 1 21.85628838 17.55540403 9131 apoptosis inducing factor mitochondria associated 1 "GO:0003677,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005758,GO:0005829,GO:0006915,GO:0006919,GO:0016174,GO:0016651,GO:0030261,GO:0033108,GO:0043065,GO:0045041,GO:0046983,GO:0048471,GO:0055114,GO:0070059,GO:0071949" "DNA binding|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|NAD(P)H oxidase H2O2-forming activity|oxidoreductase activity, acting on NAD(P)H|chromosome condensation|mitochondrial respiratory chain complex assembly|positive regulation of apoptotic process|protein import into mitochondrial intermembrane space|protein dimerization activity|perinuclear region of cytoplasm|oxidation-reduction process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|FAD binding" "hsa04210,hsa04217" Apoptosis|Necroptosis AIFM2 874.2541685 965.2231259 783.2852112 0.811506884 -0.301324762 0.404392168 1 15.58340651 13.19078184 84883 apoptosis inducing factor mitochondria associated 2 "GO:0003677,GO:0004174,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005811,GO:0005829,GO:0005886,GO:0006743,GO:0008637,GO:0016021,GO:0016655,GO:0022904,GO:0042981,GO:0043065,GO:0050660,GO:0110076,GO:1900407" "DNA binding|electron-transferring-flavoprotein dehydrogenase activity|protein binding|extracellular space|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|lipid droplet|cytosol|plasma membrane|ubiquinone metabolic process|apoptotic mitochondrial changes|integral component of membrane|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|respiratory electron transport chain|regulation of apoptotic process|positive regulation of apoptotic process|flavin adenine dinucleotide binding|negative regulation of ferroptosis|regulation of cellular response to oxidative stress" hsa04115 p53 signaling pathway AIFM3 15.91268842 10.14955968 21.67581716 2.135641135 1.094669242 0.370269595 1 0.215259377 0.479519515 150209 apoptosis inducing factor mitochondria associated 3 "GO:0005634,GO:0005739,GO:0005743,GO:0005783,GO:0005829,GO:0016491,GO:0046872,GO:0050660,GO:0051537,GO:0055114,GO:0097194" "nucleus|mitochondrion|mitochondrial inner membrane|endoplasmic reticulum|cytosol|oxidoreductase activity|metal ion binding|flavin adenine dinucleotide binding|2 iron, 2 sulfur cluster binding|oxidation-reduction process|execution phase of apoptosis" AIG1 690.6362129 603.8988012 777.3736247 1.287258102 0.364301351 0.336526274 1 3.038178589 4.079386576 51390 androgen induced 1 "GO:0005515,GO:0005886,GO:0016020,GO:0016021,GO:0016787,GO:0042758" protein binding|plasma membrane|membrane|integral component of membrane|hydrolase activity|long-chain fatty acid catabolic process AIMP1 693.3881247 724.6785614 662.0976879 0.913643266 -0.130297123 0.733129366 1 8.356651326 7.963882972 9255 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 "GO:0000049,GO:0001525,GO:0001937,GO:0005125,GO:0005515,GO:0005615,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0006418,GO:0006915,GO:0006954,GO:0007165,GO:0007267,GO:0009986,GO:0016020,GO:0017101,GO:0042803,GO:0050900,GO:0051020,GO:0051607,GO:0070094" tRNA binding|angiogenesis|negative regulation of endothelial cell proliferation|cytokine activity|protein binding|extracellular space|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|tRNA aminoacylation for protein translation|apoptotic process|inflammatory response|signal transduction|cell-cell signaling|cell surface|membrane|aminoacyl-tRNA synthetase multienzyme complex|protein homodimerization activity|leukocyte migration|GTPase binding|defense response to virus|positive regulation of glucagon secretion AIMP2 729.0249066 870.8322209 587.2175923 0.674317714 -0.568499598 0.129224165 1 20.8630936 14.6743612 7965 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 "GO:0005515,GO:0005634,GO:0005829,GO:0006418,GO:0006915,GO:0008285,GO:0016020,GO:0017101,GO:0031398,GO:0060090,GO:0060510,GO:0065003,GO:1901216,GO:1903632" protein binding|nucleus|cytosol|tRNA aminoacylation for protein translation|apoptotic process|negative regulation of cell population proliferation|membrane|aminoacyl-tRNA synthetase multienzyme complex|positive regulation of protein ubiquitination|molecular adaptor activity|type II pneumocyte differentiation|protein-containing complex assembly|positive regulation of neuron death|positive regulation of aminoacyl-tRNA ligase activity AIP 1442.053739 1287.979124 1596.128355 1.239250175 0.309467463 0.353182152 1 37.33920945 48.26585873 9049 aryl hydrocarbon receptor interacting protein "GO:0000413,GO:0003713,GO:0003755,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006626,GO:0006805,GO:0008134,GO:0010738,GO:0017162,GO:0022417,GO:0034751,GO:0035722,GO:0036004,GO:0045893,GO:0051082,GO:0051344" "protein peptidyl-prolyl isomerization|transcription coactivator activity|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein targeting to mitochondrion|xenobiotic metabolic process|transcription factor binding|regulation of protein kinase A signaling|aryl hydrocarbon receptor binding|protein maturation by protein folding|aryl hydrocarbon receptor complex|interleukin-12-mediated signaling pathway|GAF domain binding|positive regulation of transcription, DNA-templated|unfolded protein binding|negative regulation of cyclic-nucleotide phosphodiesterase activity" hsa04934 Cushing syndrome AJM1 166.8699444 159.348087 174.3918017 1.094407878 0.13015052 0.828882171 1 1.738564942 1.984659732 389813 apical junction component 1 homolog "GO:0005912,GO:0005929,GO:0016324,GO:0045216" adherens junction|cilium|apical plasma membrane|cell-cell junction organization AJUBA 1546.190647 1503.149789 1589.231504 1.057267556 0.080340517 0.809334067 1 16.10178385 17.75721395 84962 ajuba LIM protein "GO:0000086,GO:0000122,GO:0000932,GO:0001666,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0005925,GO:0006355,GO:0007010,GO:0016339,GO:0030027,GO:0030032,GO:0030334,GO:0031328,GO:0031334,GO:0033673,GO:0034613,GO:0035195,GO:0035313,GO:0035331,GO:0043087,GO:0043123,GO:0043406,GO:0045294,GO:0046474,GO:0046872,GO:0048041,GO:0051015,GO:1900037,GO:2000637" "G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|P-body|response to hypoxia|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|cell-cell junction|adherens junction|focal adhesion|regulation of transcription, DNA-templated|cytoskeleton organization|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|lamellipodium|lamellipodium assembly|regulation of cell migration|positive regulation of cellular biosynthetic process|positive regulation of protein-containing complex assembly|negative regulation of kinase activity|cellular protein localization|gene silencing by miRNA|wound healing, spreading of epidermal cells|negative regulation of hippo signaling|regulation of GTPase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|alpha-catenin binding|glycerophospholipid biosynthetic process|metal ion binding|focal adhesion assembly|actin filament binding|regulation of cellular response to hypoxia|positive regulation of gene silencing by miRNA" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species AK1 957.8328972 1021.045704 894.6200902 0.87618026 -0.190700384 0.592330735 1 16.98829267 15.52598379 203 adenylate kinase 1 "GO:0004017,GO:0004550,GO:0005524,GO:0005737,GO:0005829,GO:0006163,GO:0006165,GO:0006172,GO:0009142,GO:0015949,GO:0046033,GO:0046034,GO:0046940,GO:0070062" adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytoplasm|cytosol|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|ADP biosynthetic process|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|AMP metabolic process|ATP metabolic process|nucleoside monophosphate phosphorylation|extracellular exosome "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK2 2483.029148 2772.859706 2193.198591 0.790951878 -0.338338172 0.289154162 1 22.89461396 18.88858028 204 adenylate kinase 2 "GO:0004017,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005758,GO:0006163,GO:0006172,GO:0009132,GO:0015949,GO:0016310,GO:0046033,GO:0046034,GO:0046940,GO:0070062,GO:0097226" adenylate kinase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial intermembrane space|purine nucleotide metabolic process|ADP biosynthetic process|nucleoside diphosphate metabolic process|nucleobase-containing small molecule interconversion|phosphorylation|AMP metabolic process|ATP metabolic process|nucleoside monophosphate phosphorylation|extracellular exosome|sperm mitochondrial sheath "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK3 918.6289236 866.772397 970.4854503 1.11965431 0.163053373 0.650054166 1 9.722915641 11.35524225 50808 adenylate kinase 3 "GO:0004017,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005759,GO:0006163,GO:0006172,GO:0007596,GO:0009142,GO:0016310,GO:0046033,GO:0046039,GO:0046041,GO:0046051,GO:0046899,GO:0046940" adenylate kinase activity|protein binding|ATP binding|GTP binding|cytoplasm|mitochondrion|mitochondrial matrix|purine nucleotide metabolic process|ADP biosynthetic process|blood coagulation|nucleoside triphosphate biosynthetic process|phosphorylation|AMP metabolic process|GTP metabolic process|ITP metabolic process|UTP metabolic process|nucleoside triphosphate adenylate kinase activity|nucleoside monophosphate phosphorylation hsa00230 Purine metabolism AK4 1449.264581 2016.717509 881.8116528 0.437250953 -1.193466566 0.000397184 0.047223045 13.58059132 6.193916902 205 adenylate kinase 4 "GO:0001889,GO:0002082,GO:0004017,GO:0004550,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005759,GO:0006163,GO:0006165,GO:0006172,GO:0007420,GO:0009142,GO:0015949,GO:0042493,GO:0046033,GO:0046034,GO:0046039,GO:0046899,GO:0046940,GO:0050145,GO:0071456,GO:2001169" liver development|regulation of oxidative phosphorylation|adenylate kinase activity|nucleoside diphosphate kinase activity|protein binding|ATP binding|GTP binding|cytoplasm|mitochondrion|mitochondrial matrix|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|ADP biosynthetic process|brain development|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|response to drug|AMP metabolic process|ATP metabolic process|GTP metabolic process|nucleoside triphosphate adenylate kinase activity|nucleoside monophosphate phosphorylation|nucleoside monophosphate kinase activity|cellular response to hypoxia|regulation of ATP biosynthetic process "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK5 96.17660361 75.10674166 117.2464656 1.561064466 0.642530116 0.35143746 1 0.549377745 0.894556612 26289 adenylate kinase 5 "GO:0004017,GO:0004550,GO:0005524,GO:0005737,GO:0005829,GO:0006163,GO:0006165,GO:0006172,GO:0006173,GO:0009142,GO:0009220,GO:0015949,GO:0034451,GO:0046034,GO:0046940" adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytoplasm|cytosol|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|ADP biosynthetic process|dADP biosynthetic process|nucleoside triphosphate biosynthetic process|pyrimidine ribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|centriolar satellite|ATP metabolic process|nucleoside monophosphate phosphorylation "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK6 235.7560599 254.7539481 216.7581716 0.850853042 -0.233018122 0.652718344 1 7.191966974 6.382901904 102157402 adenylate kinase 6 "GO:0004017,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0015030,GO:0015949,GO:0016020,GO:0016310,GO:0016607,GO:0016887,GO:0046940,GO:0050145" adenylate kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|Cajal body|nucleobase-containing small molecule interconversion|membrane|phosphorylation|nuclear speck|ATPase activity|nucleoside monophosphate phosphorylation|nucleoside monophosphate kinase activity "hsa00230,hsa03008" Purine metabolism|Ribosome biogenesis in eukaryotes AK7 29.46613624 27.40381115 31.52846133 1.150513743 0.202278217 0.869978136 1 0.380561108 0.45670119 122481 adenylate kinase 7 "GO:0004017,GO:0004127,GO:0004550,GO:0005524,GO:0005737,GO:0005829,GO:0006163,GO:0006165,GO:0009142,GO:0015949,GO:0030030,GO:0031514,GO:0046940" adenylate kinase activity|cytidylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytoplasm|cytosol|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|cell projection organization|motile cilium|nucleoside monophosphate phosphorylation "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK8 9.04552906 12.17947162 5.911586499 0.485372985 -1.042834281 0.499104294 1 0.103186228 0.052241215 158067 adenylate kinase 8 "GO:0004017,GO:0004127,GO:0004550,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005930,GO:0006163,GO:0006165,GO:0009142,GO:0015949,GO:0021591,GO:0036126,GO:0046940" adenylate kinase activity|cytidylate kinase activity|nucleoside diphosphate kinase activity|protein binding|ATP binding|cytoplasm|cytosol|axoneme|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|ventricular system development|sperm flagellum|nucleoside monophosphate phosphorylation "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK9 38.15264507 48.71788648 27.58740366 0.566268483 -0.82044186 0.37698617 1 0.218895412 0.12929299 221264 adenylate kinase 9 "GO:0004017,GO:0004550,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006163,GO:0006174,GO:0006186,GO:0006756,GO:0006757,GO:0009132,GO:0015949,GO:0031965,GO:0050145,GO:0061508,GO:0061565,GO:0061566,GO:0061567,GO:0061568,GO:0061569,GO:0061570,GO:0061571" adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|purine nucleotide metabolic process|dADP phosphorylation|dGDP phosphorylation|AMP phosphorylation|ATP generation from ADP|nucleoside diphosphate metabolic process|nucleobase-containing small molecule interconversion|nuclear membrane|nucleoside monophosphate kinase activity|CDP phosphorylation|dAMP phosphorylation|CMP phosphorylation|dCMP phosphorylation|GDP phosphorylation|UDP phosphorylation|dCDP phosphorylation|TDP phosphorylation "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism AKAP1 1166.870773 1234.186458 1099.555089 0.890914887 -0.166640483 0.628711355 1 12.2973028 11.42778373 8165 A-kinase anchoring protein 1 "GO:0003723,GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0007596,GO:0016020,GO:0016021,GO:0034237,GO:0140374" RNA binding|protein binding|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|blood coagulation|membrane|integral component of membrane|protein kinase A regulatory subunit binding|antiviral innate immune response AKAP10 801.7820563 725.6935174 877.8705951 1.209698825 0.274647909 0.455172796 1 9.045979956 11.41428756 11216 A-kinase anchoring protein 10 "GO:0005515,GO:0005739,GO:0005829,GO:0005886,GO:0007165,GO:0007596,GO:0008104,GO:0032991,GO:0051018" protein binding|mitochondrion|cytosol|plasma membrane|signal transduction|blood coagulation|protein localization|protein-containing complex|protein kinase A binding AKAP11 1529.067285 1511.269437 1546.865134 1.023553508 0.033586524 0.921087635 1 7.344829243 7.841663182 11215 A-kinase anchoring protein 11 "GO:0003091,GO:0005515,GO:0005730,GO:0005737,GO:0005777,GO:0005815,GO:0005829,GO:0005886,GO:0008104,GO:0008157,GO:0019207,GO:0030866,GO:0034237,GO:0035556,GO:0036010,GO:0043549,GO:0051018" renal water homeostasis|protein binding|nucleolus|cytoplasm|peroxisome|microtubule organizing center|cytosol|plasma membrane|protein localization|protein phosphatase 1 binding|kinase regulator activity|cortical actin cytoskeleton organization|protein kinase A regulatory subunit binding|intracellular signal transduction|protein localization to endosome|regulation of kinase activity|protein kinase A binding AKAP12 14882.43045 15291.32662 14473.53428 0.946519203 -0.07929632 0.820900457 1 70.44953595 69.55422176 9590 A-kinase anchoring protein 12 "GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007186,GO:0007193,GO:0008179,GO:0010738,GO:0010739,GO:0032496,GO:0035733,GO:0043025,GO:0043116,GO:0050804,GO:0051018,GO:0051602,GO:0051770,GO:0061870,GO:0070374,GO:0071347,GO:0071356,GO:0090036,GO:0098685,GO:1900143" protein binding|calmodulin binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase binding|regulation of protein kinase A signaling|positive regulation of protein kinase A signaling|response to lipopolysaccharide|hepatic stellate cell activation|neuronal cell body|negative regulation of vascular permeability|modulation of chemical synaptic transmission|protein kinase A binding|response to electrical stimulus|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of hepatic stellate cell migration|positive regulation of ERK1 and ERK2 cascade|cellular response to interleukin-1|cellular response to tumor necrosis factor|regulation of protein kinase C signaling|Schaffer collateral - CA1 synapse|positive regulation of oligodendrocyte apoptotic process AKAP13 3047.040325 2870.295479 3223.785171 1.123154461 0.167556347 0.598711638 1 10.67408328 12.50506643 11214 A-kinase anchoring protein 13 "GO:0004691,GO:0005078,GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0005938,GO:0006468,GO:0007186,GO:0007507,GO:0015629,GO:0016020,GO:0030864,GO:0031267,GO:0035023,GO:0035025,GO:0043065,GO:0043123,GO:0043406,GO:0046872,GO:0048471,GO:0051018,GO:0051056,GO:0051168,GO:0055007,GO:0060090,GO:0060297,GO:0060348,GO:0061049,GO:0071875,GO:0086023" cAMP-dependent protein kinase activity|MAP-kinase scaffold activity|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|cell cortex|protein phosphorylation|G protein-coupled receptor signaling pathway|heart development|actin cytoskeleton|membrane|cortical actin cytoskeleton|small GTPase binding|regulation of Rho protein signal transduction|positive regulation of Rho protein signal transduction|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|metal ion binding|perinuclear region of cytoplasm|protein kinase A binding|regulation of small GTPase mediated signal transduction|nuclear export|cardiac muscle cell differentiation|molecular adaptor activity|regulation of sarcomere organization|bone development|cell growth involved in cardiac muscle cell development|adrenergic receptor signaling pathway|adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process "hsa04928,hsa05163" "Parathyroid hormone synthesis, secretion and action|Human cytomegalovirus infection" AKAP17A-2 29.39190736 22.3290313 36.45478341 1.632618223 0.707187466 0.486434112 1 0.353512555 0.602012365 8227 A-kinase anchoring protein 17A AKAP3 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.042494301 0.086056209 10566 A-kinase anchoring protein 3 "GO:0001669,GO:0001835,GO:0005515,GO:0005634,GO:0005737,GO:0007178,GO:0007338,GO:0007340,GO:0008104,GO:0035686,GO:0051018,GO:0097225,GO:0097228" acrosomal vesicle|blastocyst hatching|protein binding|nucleus|cytoplasm|transmembrane receptor protein serine/threonine kinase signaling pathway|single fertilization|acrosome reaction|protein localization|sperm fibrous sheath|protein kinase A binding|sperm midpiece|sperm principal piece AKAP5 43.03442983 45.67301858 40.39584108 0.88445744 -0.177135373 0.865646255 1 0.356586599 0.328971206 9495 A-kinase anchoring protein 5 "GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0007165,GO:0007193,GO:0007194,GO:0007268,GO:0008179,GO:0009898,GO:0010738,GO:0014069,GO:0017124,GO:0030346,GO:0031698,GO:0032590,GO:0034237,GO:0035254,GO:0043197,GO:0045121,GO:0045762,GO:0050811,GO:0051018,GO:0060076,GO:0060090,GO:0097110,GO:0098837,GO:1900273,GO:1903078,GO:1905751" protein binding|calmodulin binding|cytosol|plasma membrane|signal transduction|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|chemical synaptic transmission|adenylate cyclase binding|cytoplasmic side of plasma membrane|regulation of protein kinase A signaling|postsynaptic density|SH3 domain binding|protein phosphatase 2B binding|beta-2 adrenergic receptor binding|dendrite membrane|protein kinase A regulatory subunit binding|glutamate receptor binding|dendritic spine|membrane raft|positive regulation of adenylate cyclase activity|GABA receptor binding|protein kinase A binding|excitatory synapse|molecular adaptor activity|scaffold protein binding|postsynaptic recycling endosome|positive regulation of long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|positive regulation of endosome to plasma membrane protein transport AKAP6 54.84003545 78.15160956 31.52846133 0.403426897 -1.309620822 0.114618157 1 0.254589524 0.107132517 9472 A-kinase anchoring protein 6 "GO:0001508,GO:0005515,GO:0005635,GO:0005737,GO:0005901,GO:0006605,GO:0008179,GO:0010738,GO:0010880,GO:0014701,GO:0014704,GO:0016529,GO:0019933,GO:0030307,GO:0030315,GO:0031965,GO:0034237,GO:0034704,GO:0043495,GO:0044325,GO:0048471,GO:0051018,GO:0051281,GO:0060090,GO:0060306,GO:0060316,GO:0061051,GO:0070886,GO:0071320,GO:0071345,GO:1901381,GO:1902261" action potential|protein binding|nuclear envelope|cytoplasm|caveola|protein targeting|adenylate cyclase binding|regulation of protein kinase A signaling|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|junctional sarcoplasmic reticulum membrane|intercalated disc|sarcoplasmic reticulum|cAMP-mediated signaling|positive regulation of cell growth|T-tubule|nuclear membrane|protein kinase A regulatory subunit binding|calcium channel complex|protein-membrane adaptor activity|ion channel binding|perinuclear region of cytoplasm|protein kinase A binding|positive regulation of release of sequestered calcium ion into cytosol|molecular adaptor activity|regulation of membrane repolarization|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of cell growth involved in cardiac muscle cell development|positive regulation of calcineurin-NFAT signaling cascade|cellular response to cAMP|cellular response to cytokine stimulus|positive regulation of potassium ion transmembrane transport|positive regulation of delayed rectifier potassium channel activity AKAP7 80.17484053 58.86744617 101.4822349 1.723910948 0.785685251 0.282884216 1 0.540701574 0.97227337 9465 A-kinase anchoring protein 7 "GO:0000166,GO:0005515,GO:0005634,GO:0005829,GO:0008150,GO:0010738,GO:0032991,GO:0034237,GO:0051018" nucleotide binding|protein binding|nucleus|cytosol|biological_process|regulation of protein kinase A signaling|protein-containing complex|protein kinase A regulatory subunit binding|protein kinase A binding AKAP8 635.1832952 719.6037816 550.7628088 0.765369531 -0.385771626 0.317721303 1 9.944172695 7.938816374 10270 A-kinase anchoring protein 8 "GO:0000278,GO:0000793,GO:0001939,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0005794,GO:0007076,GO:0007165,GO:0008270,GO:0015031,GO:0016020,GO:0016363,GO:0031065,GO:0032720,GO:0033127,GO:0034237,GO:0042826,GO:0044839,GO:0045087,GO:0051059,GO:0071222,GO:0071380" mitotic cell cycle|condensed chromosome|female pronucleus|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|mitochondrion|Golgi apparatus|mitotic chromosome condensation|signal transduction|zinc ion binding|protein transport|membrane|nuclear matrix|positive regulation of histone deacetylation|negative regulation of tumor necrosis factor production|regulation of histone phosphorylation|protein kinase A regulatory subunit binding|histone deacetylase binding|cell cycle G2/M phase transition|innate immune response|NF-kappaB binding|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus AKAP8L 917.8393759 846.4732776 989.2054742 1.168619849 0.224805699 0.53072107 1 20.63083991 25.14815321 26993 A-kinase anchoring protein 8 like "GO:0000785,GO:0003677,GO:0003723,GO:0005515,GO:0005521,GO:0005634,GO:0005737,GO:0006397,GO:0007076,GO:0008380,GO:0010793,GO:0016032,GO:0016363,GO:0016605,GO:0016607,GO:0017151,GO:0031065,GO:0033127,GO:0034237,GO:0042826,GO:0044839,GO:0045944,GO:0046872,GO:0051081,GO:1990904" chromatin|DNA binding|RNA binding|protein binding|lamin binding|nucleus|cytoplasm|mRNA processing|mitotic chromosome condensation|RNA splicing|regulation of mRNA export from nucleus|viral process|nuclear matrix|PML body|nuclear speck|DEAD/H-box RNA helicase binding|positive regulation of histone deacetylation|regulation of histone phosphorylation|protein kinase A regulatory subunit binding|histone deacetylase binding|cell cycle G2/M phase transition|positive regulation of transcription by RNA polymerase II|metal ion binding|nuclear envelope disassembly|ribonucleoprotein complex AKAP9 1427.845594 1428.043048 1427.64814 0.999723462 -0.000399015 1 1 4.141159034 4.318348853 10142 A-kinase anchoring protein 9 "GO:0000086,GO:0003677,GO:0005102,GO:0005515,GO:0005794,GO:0005795,GO:0005801,GO:0005813,GO:0005829,GO:0005856,GO:0007020,GO:0007165,GO:0007268,GO:0008076,GO:0010389,GO:0015459,GO:0031116,GO:0033138,GO:0034237,GO:0043231,GO:0044325,GO:0051661,GO:0060090,GO:0060306,GO:0060307,GO:0061337,GO:0071320,GO:0086091,GO:0097060,GO:0097711,GO:0098909,GO:0098962,GO:0098978,GO:1901018,GO:1903358" G2/M transition of mitotic cell cycle|DNA binding|signaling receptor binding|protein binding|Golgi apparatus|Golgi stack|cis-Golgi network|centrosome|cytosol|cytoskeleton|microtubule nucleation|signal transduction|chemical synaptic transmission|voltage-gated potassium channel complex|regulation of G2/M transition of mitotic cell cycle|potassium channel regulator activity|positive regulation of microtubule polymerization|positive regulation of peptidyl-serine phosphorylation|protein kinase A regulatory subunit binding|intracellular membrane-bounded organelle|ion channel binding|maintenance of centrosome location|molecular adaptor activity|regulation of membrane repolarization|regulation of ventricular cardiac muscle cell membrane repolarization|cardiac conduction|cellular response to cAMP|regulation of heart rate by cardiac conduction|synaptic membrane|ciliary basal body-plasma membrane docking|regulation of cardiac muscle cell action potential involved in regulation of contraction|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse|positive regulation of potassium ion transmembrane transporter activity|regulation of Golgi organization AKIP1 430.1216116 441.5058462 418.737377 0.948429971 -0.076386841 0.8623119 1 16.62506585 16.44691976 56672 A-kinase interacting protein 1 "GO:0005515,GO:0005654,GO:0034446,GO:1901222" protein binding|nucleoplasm|substrate adhesion-dependent cell spreading|regulation of NIK/NF-kappaB signaling AKIRIN1 1688.342627 1622.914593 1753.770661 1.080630286 0.111873021 0.733426895 1 30.5784594 34.46741123 79647 akirin 1 "GO:0001228,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0010592,GO:0010759,GO:0014839,GO:0031965,GO:0045663,GO:0045944,GO:1902723,GO:1902725" "DNA-binding transcription activator activity, RNA polymerase II-specific|transcription coregulator activity|protein binding|nucleus|nucleoplasm|positive regulation of lamellipodium assembly|positive regulation of macrophage chemotaxis|myoblast migration involved in skeletal muscle regeneration|nuclear membrane|positive regulation of myoblast differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of skeletal muscle satellite cell proliferation|negative regulation of satellite cell differentiation" AKIRIN2 560.5449374 500.3732924 620.7165824 1.240507021 0.310929901 0.434692983 1 13.35202426 17.27675876 55122 akirin 2 "GO:0000122,GO:0001228,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0008284,GO:0009792,GO:0010950,GO:0017053,GO:0019899,GO:0032496,GO:0032755,GO:0042802,GO:0045087,GO:0045089,GO:0045944" "negative regulation of transcription by RNA polymerase II|DNA-binding transcription activator activity, RNA polymerase II-specific|transcription coregulator activity|protein binding|nucleus|nucleoplasm|positive regulation of cell population proliferation|embryo development ending in birth or egg hatching|positive regulation of endopeptidase activity|transcription repressor complex|enzyme binding|response to lipopolysaccharide|positive regulation of interleukin-6 production|identical protein binding|innate immune response|positive regulation of innate immune response|positive regulation of transcription by RNA polymerase II" AKNA 742.0857222 888.0864723 596.084972 0.6712015 -0.575182156 0.123404844 1 5.107124656 3.575570176 80709 AT-hook transcription factor "GO:0001650,GO:0001837,GO:0003677,GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0016020,GO:0021849,GO:0043231,GO:0045944,GO:0050727,GO:0060232,GO:0060234" fibrillar center|epithelial to mesenchymal transition|DNA binding|protein binding|nucleoplasm|centrosome|centriole|cytosol|microtubule|membrane|neuroblast division in subventricular zone|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|regulation of inflammatory response|delamination|neuroblast delamination AKNAD1 3.537500113 6.08973581 0.985264417 0.161790995 -2.627796782 0.2971307 1 0.101122503 0.017065464 254268 AKNA domain containing 1 AKR1A1 1286.694961 1477.77589 1095.614031 0.741393901 -0.431687849 0.202339611 1 47.30982019 36.58611001 10327 aldo-keto reductase family 1 member A1 "GO:0004032,GO:0004033,GO:0004745,GO:0005515,GO:0005615,GO:0005829,GO:0006006,GO:0006081,GO:0009055,GO:0016324,GO:0019640,GO:0019853,GO:0022900,GO:0042840,GO:0044597,GO:0044598,GO:0045202,GO:0046185,GO:0047655,GO:0047939,GO:0047941,GO:0070062,GO:0110095,GO:1901687" alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|retinol dehydrogenase activity|protein binding|extracellular space|cytosol|glucose metabolic process|cellular aldehyde metabolic process|electron transfer activity|apical plasma membrane|glucuronate catabolic process to xylulose 5-phosphate|L-ascorbic acid biosynthetic process|electron transport chain|D-glucuronate catabolic process|daunorubicin metabolic process|doxorubicin metabolic process|synapse|aldehyde catabolic process|allyl-alcohol dehydrogenase activity|L-glucuronate reductase activity|glucuronolactone reductase activity|extracellular exosome|cellular detoxification of aldehyde|glutathione derivative biosynthetic process "hsa00010,hsa00040,hsa00053,hsa00561" Glycolysis / Gluconeogenesis|Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Glycerolipid metabolism AKR1B1 19051.79139 25510.91827 12592.66451 0.493618629 -1.018531251 0.005227469 0.276769986 870.059268 447.9776107 231 aldo-keto reductase family 1 member B "GO:0001523,GO:0001758,GO:0001894,GO:0002070,GO:0003091,GO:0004032,GO:0005515,GO:0005615,GO:0005654,GO:0005829,GO:0005975,GO:0006061,GO:0006700,GO:0009055,GO:0009414,GO:0018931,GO:0022900,GO:0031098,GO:0032838,GO:0033010,GO:0035809,GO:0042415,GO:0042572,GO:0042629,GO:0043066,GO:0043220,GO:0043795,GO:0044597,GO:0044598,GO:0046370,GO:0046427,GO:0047655,GO:0048471,GO:0048661,GO:0052650,GO:0055114,GO:0060135,GO:0070062,GO:0071475,GO:0072061,GO:0072205,GO:0097066,GO:0097238,GO:0097454,GO:1901653" retinoid metabolic process|retinal dehydrogenase activity|tissue homeostasis|epithelial cell maturation|renal water homeostasis|alditol:NADP+ 1-oxidoreductase activity|protein binding|extracellular space|nucleoplasm|cytosol|carbohydrate metabolic process|sorbitol biosynthetic process|C21-steroid hormone biosynthetic process|electron transfer activity|response to water deprivation|naphthalene metabolic process|electron transport chain|stress-activated protein kinase signaling cascade|plasma membrane bounded cell projection cytoplasm|paranodal junction|regulation of urine volume|norepinephrine metabolic process|retinol metabolic process|mast cell granule|negative regulation of apoptotic process|Schmidt-Lanterman incisure|glyceraldehyde oxidoreductase activity|daunorubicin metabolic process|doxorubicin metabolic process|fructose biosynthetic process|positive regulation of receptor signaling pathway via JAK-STAT|allyl-alcohol dehydrogenase activity|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|NADP-retinol dehydrogenase activity|oxidation-reduction process|maternal process involved in female pregnancy|extracellular exosome|cellular hyperosmotic salinity response|inner medullary collecting duct development|metanephric collecting duct development|response to thyroid hormone|cellular response to methylglyoxal|Schwann cell microvillus|cellular response to peptide "hsa00040,hsa00051,hsa00052,hsa00561,hsa00790" Pentose and glucuronate interconversions|Fructose and mannose metabolism|Galactose metabolism|Glycerolipid metabolism|Folate biosynthesis AKR1C1 203.8618973 162.3929549 245.3308397 1.510723417 0.595239556 0.267151292 1 2.548692371 4.016227537 1645 aldo-keto reductase family 1 member C1 "GO:0001523,GO:0004032,GO:0004033,GO:0004303,GO:0005515,GO:0005829,GO:0006693,GO:0006805,GO:0007586,GO:0008202,GO:0008206,GO:0015721,GO:0016229,GO:0016655,GO:0018636,GO:0030283,GO:0030299,GO:0030855,GO:0031406,GO:0032052,GO:0035410,GO:0042448,GO:0042574,GO:0042632,GO:0044597,GO:0044598,GO:0046683,GO:0047006,GO:0047023,GO:0047024,GO:0047042,GO:0047044,GO:0047086,GO:0047115,GO:0047718,GO:0055114,GO:0070062,GO:0071395" "retinoid metabolic process|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|estradiol 17-beta-dehydrogenase activity|protein binding|cytosol|prostaglandin metabolic process|xenobiotic metabolic process|digestion|steroid metabolic process|bile acid metabolic process|bile acid and bile salt transport|steroid dehydrogenase activity|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|testosterone dehydrogenase [NAD(P)] activity|intestinal cholesterol absorption|epithelial cell differentiation|carboxylic acid binding|bile acid binding|dihydrotestosterone 17-beta-dehydrogenase activity|progesterone metabolic process|retinal metabolic process|cholesterol homeostasis|daunorubicin metabolic process|doxorubicin metabolic process|response to organophosphorus|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|androsterone dehydrogenase activity|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|androsterone dehydrogenase (B-specific) activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|ketosteroid monooxygenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|indanol dehydrogenase activity|oxidation-reduction process|extracellular exosome|cellular response to jasmonic acid stimulus" "hsa00140,hsa00980" Steroid hormone biosynthesis|Metabolism of xenobiotics by cytochrome P450 AKR1C2 9.463932389 7.104691779 11.823173 1.664135949 0.734773297 0.648013687 1 0.090728082 0.157487636 1646 aldo-keto reductase family 1 member C2 "GO:0004032,GO:0004303,GO:0005829,GO:0006693,GO:0007186,GO:0007586,GO:0008202,GO:0008284,GO:0016229,GO:0016655,GO:0018636,GO:0030855,GO:0031406,GO:0032052,GO:0042448,GO:0044597,GO:0044598,GO:0047023,GO:0047044,GO:0047086,GO:0047115,GO:0047718,GO:0051897,GO:0055114,GO:0071395,GO:0071799" "alditol:NADP+ 1-oxidoreductase activity|estradiol 17-beta-dehydrogenase activity|cytosol|prostaglandin metabolic process|G protein-coupled receptor signaling pathway|digestion|steroid metabolic process|positive regulation of cell population proliferation|steroid dehydrogenase activity|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|epithelial cell differentiation|carboxylic acid binding|bile acid binding|progesterone metabolic process|daunorubicin metabolic process|doxorubicin metabolic process|androsterone dehydrogenase activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|ketosteroid monooxygenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|indanol dehydrogenase activity|positive regulation of protein kinase B signaling|oxidation-reduction process|cellular response to jasmonic acid stimulus|cellular response to prostaglandin D stimulus" "hsa00140,hsa05204" Steroid hormone biosynthesis|Chemical carcinogenesis AKR1C3 794.3980163 658.7064235 930.0896092 1.411994139 0.4977341 0.176291663 1 17.31248395 25.49812275 8644 aldo-keto reductase family 1 member C3 "GO:0001523,GO:0001758,GO:0004032,GO:0004033,GO:0004303,GO:0004745,GO:0005634,GO:0005737,GO:0005829,GO:0006693,GO:0007186,GO:0007584,GO:0008202,GO:0008284,GO:0008584,GO:0009267,GO:0010942,GO:0016229,GO:0016488,GO:0016655,GO:0018636,GO:0019371,GO:0030216,GO:0032052,GO:0034614,GO:0035410,GO:0036130,GO:0036131,GO:0042448,GO:0042572,GO:0042574,GO:0043170,GO:0044597,GO:0044598,GO:0045550,GO:0045703,GO:0047017,GO:0047020,GO:0047023,GO:0047024,GO:0047035,GO:0047044,GO:0047045,GO:0047086,GO:0047787,GO:0048385,GO:0051897,GO:0052650,GO:0055114,GO:0061370,GO:0070062,GO:0070293,GO:0071276,GO:0071277,GO:0071379,GO:0071384,GO:0071395,GO:0071799,GO:1900053,GO:2000224,GO:2000353,GO:2000379" "retinoid metabolic process|retinal dehydrogenase activity|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|nucleus|cytoplasm|cytosol|prostaglandin metabolic process|G protein-coupled receptor signaling pathway|response to nutrient|steroid metabolic process|positive regulation of cell population proliferation|male gonad development|cellular response to starvation|positive regulation of cell death|steroid dehydrogenase activity|farnesol catabolic process|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|cyclooxygenase pathway|keratinocyte differentiation|bile acid binding|cellular response to reactive oxygen species|dihydrotestosterone 17-beta-dehydrogenase activity|prostaglandin H2 endoperoxidase reductase activity|prostaglandin D2 11-ketoreductase activity|progesterone metabolic process|retinol metabolic process|retinal metabolic process|macromolecule metabolic process|daunorubicin metabolic process|doxorubicin metabolic process|geranylgeranyl reductase activity|ketoreductase activity|prostaglandin-F synthase activity|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity|androsterone dehydrogenase activity|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NADP+) activity|ketosteroid monooxygenase activity|delta4-3-oxosteroid 5beta-reductase activity|regulation of retinoic acid receptor signaling pathway|positive regulation of protein kinase B signaling|NADP-retinol dehydrogenase activity|oxidation-reduction process|testosterone biosynthetic process|extracellular exosome|renal absorption|cellular response to cadmium ion|cellular response to calcium ion|cellular response to prostaglandin stimulus|cellular response to corticosteroid stimulus|cellular response to jasmonic acid stimulus|cellular response to prostaglandin D stimulus|negative regulation of retinoic acid biosynthetic process|regulation of testosterone biosynthetic process|positive regulation of endothelial cell apoptotic process|positive regulation of reactive oxygen species metabolic process" "hsa00140,hsa00590,hsa00790,hsa04913" Steroid hormone biosynthesis|Arachidonic acid metabolism|Folate biosynthesis|Ovarian steroidogenesis AKR7A2 760.8638914 723.6636055 798.0641774 1.10281099 0.14118555 0.705762439 1 14.00497084 16.11013665 8574 aldo-keto reductase family 7 member A2 "GO:0004032,GO:0005515,GO:0005794,GO:0005829,GO:0005975,GO:0006081,GO:0006805,GO:0009055,GO:0019119,GO:0022900,GO:0044597,GO:0044598,GO:0070062" "alditol:NADP+ 1-oxidoreductase activity|protein binding|Golgi apparatus|cytosol|carbohydrate metabolic process|cellular aldehyde metabolic process|xenobiotic metabolic process|electron transfer activity|phenanthrene-9,10-epoxide hydrolase activity|electron transport chain|daunorubicin metabolic process|doxorubicin metabolic process|extracellular exosome" hsa00980 Metabolism of xenobiotics by cytochrome P450 AKR7A3 7.523095107 9.134603715 5.911586499 0.64716398 -0.627796782 0.748279434 1 0.280725396 0.189501203 22977 aldo-keto reductase family 7 member A3 "GO:0004033,GO:0005515,GO:0005829,GO:0006081,GO:0006805,GO:0009055,GO:0022900,GO:0042802,GO:0046223,GO:0070062" aldo-keto reductase (NADP) activity|protein binding|cytosol|cellular aldehyde metabolic process|xenobiotic metabolic process|electron transfer activity|electron transport chain|identical protein binding|aflatoxin catabolic process|extracellular exosome hsa00980 Metabolism of xenobiotics by cytochrome P450 AKT1 4943.639691 4215.112137 5672.167246 1.345674104 0.428329059 0.18242902 1 62.84385037 88.21016013 207 AKT serine/threonine kinase 1 "GO:0001649,GO:0001893,GO:0001934,GO:0001938,GO:0002042,GO:0003376,GO:0004672,GO:0004674,GO:0004712,GO:0005080,GO:0005515,GO:0005516,GO:0005524,GO:0005547,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005819,GO:0005829,GO:0005886,GO:0005911,GO:0005978,GO:0005979,GO:0006006,GO:0006412,GO:0006417,GO:0006468,GO:0006469,GO:0006606,GO:0006809,GO:0006924,GO:0006954,GO:0006974,GO:0006979,GO:0007165,GO:0007173,GO:0007186,GO:0007249,GO:0007281,GO:0007568,GO:0008283,GO:0008284,GO:0008286,GO:0008637,GO:0008643,GO:0009408,GO:0010507,GO:0010595,GO:0010628,GO:0010629,GO:0010748,GO:0010761,GO:0010763,GO:0010765,GO:0010907,GO:0010918,GO:0010951,GO:0010975,GO:0014065,GO:0015630,GO:0016242,GO:0016301,GO:0016310,GO:0016567,GO:0018105,GO:0018107,GO:0019221,GO:0019899,GO:0021510,GO:0030027,GO:0030030,GO:0030154,GO:0030163,GO:0030212,GO:0030235,GO:0030307,GO:0030334,GO:0031018,GO:0031234,GO:0031295,GO:0031397,GO:0031641,GO:0031663,GO:0031929,GO:0031982,GO:0031999,GO:0032079,GO:0032091,GO:0032094,GO:0032148,GO:0032270,GO:0032287,GO:0032436,GO:0032794,GO:0032869,GO:0032991,GO:0033138,GO:0034405,GO:0034614,GO:0035556,GO:0035655,GO:0035924,GO:0036064,GO:0038061,GO:0042593,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043066,GO:0043154,GO:0043276,GO:0043325,GO:0043488,GO:0043491,GO:0043536,GO:0045429,GO:0045600,GO:0045725,GO:0045737,GO:0045742,GO:0045746,GO:0045792,GO:0045861,GO:0045893,GO:0045907,GO:0045944,GO:0046326,GO:0046329,GO:0046622,GO:0046777,GO:0046889,GO:0048009,GO:0048661,GO:0050999,GO:0051000,GO:0051091,GO:0051146,GO:0051721,GO:0051898,GO:0060079,GO:0060416,GO:0060644,GO:0060716,GO:0070141,GO:0071260,GO:0071276,GO:0071356,GO:0071364,GO:0071380,GO:0071407,GO:0071456,GO:0071889,GO:0071901,GO:0072655,GO:0072656,GO:0090201,GO:0097011,GO:0097194,GO:0098794,GO:0100002,GO:0106310,GO:0106311,GO:0140052,GO:1900087,GO:1900182,GO:1901215,GO:1901796,GO:1902176,GO:1903038,GO:1903078,GO:1903721,GO:1990090,GO:1990418,GO:2000010,GO:2000402,GO:2001240" "osteoblast differentiation|maternal placenta development|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|sphingosine-1-phosphate receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein kinase C binding|protein binding|calmodulin binding|ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|spindle|cytosol|plasma membrane|cell-cell junction|glycogen biosynthetic process|regulation of glycogen biosynthetic process|glucose metabolic process|translation|regulation of translation|protein phosphorylation|negative regulation of protein kinase activity|protein import into nucleus|nitric oxide biosynthetic process|activation-induced cell death of T cells|inflammatory response|cellular response to DNA damage stimulus|response to oxidative stress|signal transduction|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|germ cell development|aging|cell population proliferation|positive regulation of cell population proliferation|insulin receptor signaling pathway|apoptotic mitochondrial changes|carbohydrate transport|response to heat|negative regulation of autophagy|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|negative regulation of long-chain fatty acid import across plasma membrane|fibroblast migration|positive regulation of fibroblast migration|positive regulation of sodium ion transport|positive regulation of glucose metabolic process|positive regulation of mitochondrial membrane potential|negative regulation of endopeptidase activity|regulation of neuron projection development|phosphatidylinositol 3-kinase signaling|microtubule cytoskeleton|negative regulation of macroautophagy|kinase activity|phosphorylation|protein ubiquitination|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cytokine-mediated signaling pathway|enzyme binding|spinal cord development|lamellipodium|cell projection organization|cell differentiation|protein catabolic process|hyaluronan metabolic process|nitric-oxide synthase regulator activity|positive regulation of cell growth|regulation of cell migration|endocrine pancreas development|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|negative regulation of protein ubiquitination|regulation of myelination|lipopolysaccharide-mediated signaling pathway|TOR signaling|vesicle|negative regulation of fatty acid beta-oxidation|positive regulation of endodeoxyribonuclease activity|negative regulation of protein binding|response to food|activation of protein kinase B activity|positive regulation of cellular protein metabolic process|peripheral nervous system myelin maintenance|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|GTPase activating protein binding|cellular response to insulin stimulus|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|response to fluid shear stress|cellular response to reactive oxygen species|intracellular signal transduction|interleukin-18-mediated signaling pathway|cellular response to vascular endothelial growth factor stimulus|ciliary basal body|NIK/NF-kappaB signaling|glucose homeostasis|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|anoikis|phosphatidylinositol-3,4-bisphosphate binding|regulation of mRNA stability|protein kinase B signaling|positive regulation of blood vessel endothelial cell migration|positive regulation of nitric oxide biosynthetic process|positive regulation of fat cell differentiation|positive regulation of glycogen biosynthetic process|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of epidermal growth factor receptor signaling pathway|negative regulation of Notch signaling pathway|negative regulation of cell size|negative regulation of proteolysis|positive regulation of transcription, DNA-templated|positive regulation of vasoconstriction|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|negative regulation of JNK cascade|positive regulation of organ growth|protein autophosphorylation|positive regulation of lipid biosynthetic process|insulin-like growth factor receptor signaling pathway|positive regulation of smooth muscle cell proliferation|regulation of nitric-oxide synthase activity|positive regulation of nitric-oxide synthase activity|positive regulation of DNA-binding transcription factor activity|striated muscle cell differentiation|protein phosphatase 2A binding|negative regulation of protein kinase B signaling|excitatory postsynaptic potential|response to growth hormone|mammary gland epithelial cell differentiation|labyrinthine layer blood vessel development|response to UV-A|cellular response to mechanical stimulus|cellular response to cadmium ion|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to prostaglandin E stimulus|cellular response to organic cyclic compound|cellular response to hypoxia|14-3-3 protein binding|negative regulation of protein serine/threonine kinase activity|establishment of protein localization to mitochondrion|maintenance of protein location in mitochondrion|negative regulation of release of cytochrome c from mitochondria|cellular response to granulocyte macrophage colony-stimulating factor stimulus|execution phase of apoptosis|postsynapse|negative regulation of protein kinase activity by protein phosphorylation|protein serine kinase activity|protein threonine kinase activity|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of protein localization to nucleus|negative regulation of neuron death|regulation of signal transduction by p53 class mediator|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of leukocyte cell-cell adhesion|positive regulation of protein localization to plasma membrane|positive regulation of I-kappaB phosphorylation|cellular response to nerve growth factor stimulus|response to insulin-like growth factor stimulus|positive regulation of protein localization to cell surface|negative regulation of lymphocyte migration|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04261,hsa04370,hsa04371,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04722,hsa04725,hsa04728,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04920,hsa04922,hsa04923,hsa04926,hsa04929,hsa04931,hsa04932,hsa04933,hsa04935,hsa04973,hsa05010,hsa05017,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" AKT1S1 1044.282304 1205.76769 882.7969172 0.732145109 -0.44979848 0.198617013 1 20.28833217 15.49385338 84335 AKT1 substrate 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006469,GO:0031931,GO:0032007,GO:0042981,GO:0043523,GO:0045792,GO:0048011,GO:1900034" protein binding|nucleoplasm|cytoplasm|cytosol|negative regulation of protein kinase activity|TORC1 complex|negative regulation of TOR signaling|regulation of apoptotic process|regulation of neuron apoptotic process|negative regulation of cell size|neurotrophin TRK receptor signaling pathway|regulation of cellular response to heat "hsa04140,hsa04150,hsa04152,hsa04211,hsa04213,hsa04714,hsa05131" Autophagy - animal|mTOR signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Thermogenesis|Shigellosis AKT2 2032.414185 2109.078502 1955.749867 0.92730065 -0.108890928 0.736070316 1 12.56675127 12.15512735 208 AKT serine/threonine kinase 2 "GO:0001934,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005769,GO:0005829,GO:0005886,GO:0005938,GO:0005978,GO:0006006,GO:0006417,GO:0006464,GO:0007165,GO:0008284,GO:0008286,GO:0008643,GO:0010748,GO:0010907,GO:0010918,GO:0018105,GO:0030334,GO:0030335,GO:0031340,GO:0032000,GO:0032287,GO:0032587,GO:0032869,GO:0032991,GO:0035556,GO:0043066,GO:0043231,GO:0045444,GO:0045725,GO:0046326,GO:0046872,GO:0060644,GO:0065002,GO:0071156,GO:0071486,GO:0072659,GO:0090314,GO:0090630,GO:0097473,GO:0106310,GO:0106311,GO:2000147" positive regulation of protein phosphorylation|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|early endosome|cytosol|plasma membrane|cell cortex|glycogen biosynthetic process|glucose metabolic process|regulation of translation|cellular protein modification process|signal transduction|positive regulation of cell population proliferation|insulin receptor signaling pathway|carbohydrate transport|negative regulation of long-chain fatty acid import across plasma membrane|positive regulation of glucose metabolic process|positive regulation of mitochondrial membrane potential|peptidyl-serine phosphorylation|regulation of cell migration|positive regulation of cell migration|positive regulation of vesicle fusion|positive regulation of fatty acid beta-oxidation|peripheral nervous system myelin maintenance|ruffle membrane|cellular response to insulin stimulus|protein-containing complex|intracellular signal transduction|negative regulation of apoptotic process|intracellular membrane-bounded organelle|fat cell differentiation|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|metal ion binding|mammary gland epithelial cell differentiation|intracellular protein transmembrane transport|regulation of cell cycle arrest|cellular response to high light intensity|protein localization to plasma membrane|positive regulation of protein targeting to membrane|activation of GTPase activity|retinal rod cell apoptotic process|protein serine kinase activity|protein threonine kinase activity|positive regulation of cell motility "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04261,hsa04370,hsa04371,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04722,hsa04725,hsa04728,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04920,hsa04922,hsa04923,hsa04926,hsa04929,hsa04931,hsa04932,hsa04933,hsa04935,hsa04973,hsa05010,hsa05017,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" AKT3 2818.394646 2192.304892 3444.4844 1.57117033 0.651839591 0.041179164 0.932694318 17.19301777 28.17677676 10000 AKT serine/threonine kinase 3 "GO:0000002,GO:0001938,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007165,GO:0016020,GO:0018105,GO:0032008,GO:0035556,GO:0043536,GO:0045766,GO:0045793,GO:0048854,GO:0048873,GO:0090050,GO:0106310,GO:0106311,GO:1905564,GO:1905653,GO:2000773" mitochondrial genome maintenance|positive regulation of endothelial cell proliferation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|signal transduction|membrane|peptidyl-serine phosphorylation|positive regulation of TOR signaling|intracellular signal transduction|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of cell size|brain morphogenesis|homeostasis of number of cells within a tissue|positive regulation of cell migration involved in sprouting angiogenesis|protein serine kinase activity|protein threonine kinase activity|positive regulation of vascular endothelial cell proliferation|positive regulation of artery morphogenesis|negative regulation of cellular senescence "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04261,hsa04370,hsa04371,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04722,hsa04725,hsa04728,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04920,hsa04922,hsa04923,hsa04926,hsa04929,hsa04931,hsa04932,hsa04933,hsa04935,hsa04973,hsa05010,hsa05017,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" AKTIP 297.0502945 268.9633316 325.1372575 1.208853473 0.273639384 0.566789122 1 4.669881351 5.888374708 64400 AKT interacting protein "GO:0000209,GO:0001934,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006915,GO:0006974,GO:0007032,GO:0007040,GO:0008333,GO:0015031,GO:0018215,GO:0019787,GO:0030897,GO:0032092,GO:0045022,GO:0061631,GO:0070695" protein polyubiquitination|positive regulation of protein phosphorylation|protein binding|nucleus|cytosol|plasma membrane|apoptotic process|cellular response to DNA damage stimulus|endosome organization|lysosome organization|endosome to lysosome transport|protein transport|protein phosphopantetheinylation|ubiquitin-like protein transferase activity|HOPS complex|positive regulation of protein binding|early endosome to late endosome transport|ubiquitin conjugating enzyme activity|FHF complex ALAD 797.0823802 875.9070007 718.2577597 0.820016005 -0.286276026 0.436732103 1 11.95408234 10.22479247 210 aminolevulinate dehydratase "GO:0001666,GO:0003824,GO:0004655,GO:0005576,GO:0005634,GO:0005829,GO:0006782,GO:0006783,GO:0006979,GO:0008270,GO:0009635,GO:0010039,GO:0010043,GO:0010044,GO:0010212,GO:0010266,GO:0010269,GO:0014823,GO:0032025,GO:0032496,GO:0033197,GO:0034774,GO:0042493,GO:0042802,GO:0043200,GO:0043312,GO:0045471,GO:0046685,GO:0046686,GO:0046689,GO:0051260,GO:0051384,GO:0051597,GO:0070062,GO:0070541,GO:0070542,GO:0071284,GO:0071353,GO:1901799,GO:1904813,GO:1904854" response to hypoxia|catalytic activity|porphobilinogen synthase activity|extracellular region|nucleus|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|response to oxidative stress|zinc ion binding|response to herbicide|response to iron ion|response to zinc ion|response to aluminum ion|response to ionizing radiation|response to vitamin B1|response to selenium ion|response to activity|response to cobalt ion|response to lipopolysaccharide|response to vitamin E|secretory granule lumen|response to drug|identical protein binding|response to amino acid|neutrophil degranulation|response to ethanol|response to arsenic-containing substance|response to cadmium ion|response to mercury ion|protein homooligomerization|response to glucocorticoid|response to methylmercury|extracellular exosome|response to platinum ion|response to fatty acid|cellular response to lead ion|cellular response to interleukin-4|negative regulation of proteasomal protein catabolic process|ficolin-1-rich granule lumen|proteasome core complex binding hsa00860 Porphyrin and chlorophyll metabolism ALAS1 1292.273259 1353.951262 1230.595256 0.908891842 -0.137819471 0.684914945 1 27.84119162 26.39465285 211 5'-aminolevulinate synthase 1 "GO:0001666,GO:0003870,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006782,GO:0006783,GO:0007005,GO:0019216,GO:0030170,GO:0042541,GO:0042802,GO:0048821" response to hypoxia|5-aminolevulinate synthase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|mitochondrion organization|regulation of lipid metabolic process|pyridoxal phosphate binding|hemoglobin biosynthetic process|identical protein binding|erythrocyte development "hsa00260,hsa00860" "Glycine, serine and threonine metabolism|Porphyrin and chlorophyll metabolism" ALCAM 5467.965402 5674.618819 5261.311984 0.92716571 -0.109100884 0.735479913 1 46.61035101 45.07706847 214 activated leukocyte cell adhesion molecule "GO:0001772,GO:0002250,GO:0005102,GO:0005515,GO:0005887,GO:0005925,GO:0007155,GO:0007157,GO:0007165,GO:0008045,GO:0009897,GO:0030424,GO:0030425,GO:0031226,GO:0031290,GO:0042101,GO:0042802,GO:0043025,GO:0048846,GO:0070062,GO:1990138" immunological synapse|adaptive immune response|signaling receptor binding|protein binding|integral component of plasma membrane|focal adhesion|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|motor neuron axon guidance|external side of plasma membrane|axon|dendrite|intrinsic component of plasma membrane|retinal ganglion cell axon guidance|T cell receptor complex|identical protein binding|neuronal cell body|axon extension involved in axon guidance|extracellular exosome|neuron projection extension hsa04514 Cell adhesion molecules ALDH16A1 562.5478794 468.9096574 656.1861014 1.399387048 0.484795044 0.222196148 1 7.505884934 10.9560923 126133 aldehyde dehydrogenase 16 family member A1 "GO:0005515,GO:0016020,GO:0016620,GO:0055114" "protein binding|membrane|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|oxidation-reduction process" ALDH18A1 5868.972478 7089.467439 4648.477517 0.655687829 -0.608918978 0.060838318 1 98.02252679 67.04076259 5832 aldehyde dehydrogenase 18 family member A1 "GO:0003723,GO:0004349,GO:0004350,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0006536,GO:0006561,GO:0006592,GO:0008652,GO:0016310,GO:0019240,GO:0042802,GO:0055114,GO:0055129" RNA binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|glutamate metabolic process|proline biosynthetic process|ornithine biosynthetic process|cellular amino acid biosynthetic process|phosphorylation|citrulline biosynthetic process|identical protein binding|oxidation-reduction process|L-proline biosynthetic process hsa00330 Arginine and proline metabolism ALDH1A1 29.76305176 47.70293051 11.823173 0.247850035 -2.012460632 0.048393381 1 1.152664668 0.297994258 216 aldehyde dehydrogenase 1 family member A1 "GO:0001523,GO:0001758,GO:0004029,GO:0005096,GO:0005497,GO:0005515,GO:0005737,GO:0005829,GO:0006069,GO:0006081,GO:0018479,GO:0042572,GO:0043547,GO:0051287,GO:0055114,GO:0061624,GO:0070062,GO:0120163" retinoid metabolic process|retinal dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|GTPase activator activity|androgen binding|protein binding|cytoplasm|cytosol|ethanol oxidation|cellular aldehyde metabolic process|benzaldehyde dehydrogenase (NAD+) activity|retinol metabolic process|positive regulation of GTPase activity|NAD binding|oxidation-reduction process|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|extracellular exosome|negative regulation of cold-induced thermogenesis hsa00830 Retinol metabolism ALDH1A3 20903.63593 22078.33718 19728.93468 0.893587887 -0.162318465 0.657505103 1 322.337818 300.4446429 220 aldehyde dehydrogenase 1 family member A3 "GO:0001758,GO:0002072,GO:0002138,GO:0004029,GO:0004030,GO:0005737,GO:0005829,GO:0007626,GO:0021768,GO:0031076,GO:0042472,GO:0042572,GO:0042573,GO:0042574,GO:0042803,GO:0043065,GO:0048048,GO:0050885,GO:0051289,GO:0055114,GO:0060013,GO:0060166,GO:0060324,GO:0070062,GO:0070324,GO:0070384,GO:0070403" retinal dehydrogenase activity|optic cup morphogenesis involved in camera-type eye development|retinoic acid biosynthetic process|aldehyde dehydrogenase (NAD+) activity|aldehyde dehydrogenase [NAD(P)+] activity|cytoplasm|cytosol|locomotory behavior|nucleus accumbens development|embryonic camera-type eye development|inner ear morphogenesis|retinol metabolic process|retinoic acid metabolic process|retinal metabolic process|protein homodimerization activity|positive regulation of apoptotic process|embryonic eye morphogenesis|neuromuscular process controlling balance|protein homotetramerization|oxidation-reduction process|righting reflex|olfactory pit development|face development|extracellular exosome|thyroid hormone binding|Harderian gland development|NAD+ binding hsa00830 Retinol metabolism ALDH1B1 855.1251439 1038.299956 671.9503321 0.64716398 -0.627796782 0.083798017 1 16.876197 11.39212794 219 aldehyde dehydrogenase 1 family member B1 "GO:0004029,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0005975,GO:0006068,GO:0006069,GO:0043231,GO:0043878,GO:0051287" aldehyde dehydrogenase (NAD+) activity|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|carbohydrate metabolic process|ethanol catabolic process|ethanol oxidation|intracellular membrane-bounded organelle|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|NAD binding "hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620,hsa00770" "Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism|Pantothenate and CoA biosynthesis" ALDH1L1 10.04563925 13.19442759 6.896850916 0.522709369 -0.935919077 0.529573094 1 0.193192024 0.105333231 10840 aldehyde dehydrogenase 1 family member L1 "GO:0003824,GO:0004029,GO:0005829,GO:0006730,GO:0009058,GO:0009258,GO:0016155,GO:0016742,GO:0046655,GO:0055114,GO:0070062" "catalytic activity|aldehyde dehydrogenase (NAD+) activity|cytosol|one-carbon metabolic process|biosynthetic process|10-formyltetrahydrofolate catabolic process|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|folic acid metabolic process|oxidation-reduction process|extracellular exosome" hsa00670 One carbon pool by folate ALDH1L2 388.4841686 289.262451 487.7058862 1.686032475 0.753632325 0.085438249 1 1.818309878 3.197788697 160428 aldehyde dehydrogenase 1 family member L2 "GO:0004029,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0006730,GO:0009058,GO:0009258,GO:0016155,GO:0016742,GO:0046655,GO:0055114,GO:0070062" "aldehyde dehydrogenase (NAD+) activity|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|one-carbon metabolic process|biosynthetic process|10-formyltetrahydrofolate catabolic process|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|folic acid metabolic process|oxidation-reduction process|extracellular exosome" hsa00670 One carbon pool by folate ALDH2 648.7097731 701.3345741 596.084972 0.84992954 -0.234584849 0.542624934 1 3.715105326 3.293593405 217 aldehyde dehydrogenase 2 family member "GO:0004029,GO:0004030,GO:0005759,GO:0005975,GO:0006066,GO:0006068,GO:0006069,GO:0009055,GO:0022900,GO:0043878,GO:0051287,GO:0070062" aldehyde dehydrogenase (NAD+) activity|aldehyde dehydrogenase [NAD(P)+] activity|mitochondrial matrix|carbohydrate metabolic process|alcohol metabolic process|ethanol catabolic process|ethanol oxidation|electron transfer activity|electron transport chain|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|NAD binding|extracellular exosome "hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620,hsa00770" "Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism|Pantothenate and CoA biosynthesis" ALDH3A1 5.478337395 4.059823873 6.896850916 1.698805448 0.764520641 0.742562249 1 0.069161035 0.122552185 218 aldehyde dehydrogenase 3 family member A1 "GO:0001666,GO:0004028,GO:0004029,GO:0004030,GO:0005515,GO:0005615,GO:0005783,GO:0005829,GO:0005886,GO:0006081,GO:0006805,GO:0007568,GO:0007584,GO:0008106,GO:0008284,GO:0018479,GO:0042493,GO:0051384,GO:0051591,GO:0055114" response to hypoxia|3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|aldehyde dehydrogenase [NAD(P)+] activity|protein binding|extracellular space|endoplasmic reticulum|cytosol|plasma membrane|cellular aldehyde metabolic process|xenobiotic metabolic process|aging|response to nutrient|alcohol dehydrogenase (NADP+) activity|positive regulation of cell population proliferation|benzaldehyde dehydrogenase (NAD+) activity|response to drug|response to glucocorticoid|response to cAMP|oxidation-reduction process "hsa00010,hsa00340,hsa00350,hsa00360,hsa00410,hsa00980,hsa00982,hsa05204" Glycolysis / Gluconeogenesis|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ALDH3A2 533.6228721 579.5398579 487.7058862 0.841539852 -0.248896502 0.537378881 1 7.382205561 6.48002604 224 aldehyde dehydrogenase 3 family member A2 "GO:0001561,GO:0004028,GO:0004029,GO:0005515,GO:0005778,GO:0005789,GO:0006081,GO:0007417,GO:0007422,GO:0008544,GO:0016021,GO:0030148,GO:0033306,GO:0042803,GO:0043231,GO:0043878,GO:0046458,GO:0046577,GO:0050061,GO:0052814,GO:0055114" fatty acid alpha-oxidation|3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|protein binding|peroxisomal membrane|endoplasmic reticulum membrane|cellular aldehyde metabolic process|central nervous system development|peripheral nervous system development|epidermis development|integral component of membrane|sphingolipid biosynthetic process|phytol metabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|hexadecanal metabolic process|long-chain-alcohol oxidase activity|long-chain-aldehyde dehydrogenase activity|medium-chain-aldehyde dehydrogenase activity|oxidation-reduction process "hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620,hsa00770" "Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism|Pantothenate and CoA biosynthesis" ALDH3B1 273.6887399 254.7539481 292.6235317 1.148651607 0.199941286 0.685748414 1 4.36333742 5.227849212 221 aldehyde dehydrogenase 3 family member B1 "GO:0004028,GO:0004030,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006068,GO:0006629,GO:0018477,GO:0018479,GO:0030148,GO:0030667,GO:0031982,GO:0034599,GO:0035579,GO:0043312,GO:0046185,GO:0055114,GO:0070062" 3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase [NAD(P)+] activity|protein binding|cytoplasm|cytosol|plasma membrane|alcohol metabolic process|ethanol catabolic process|lipid metabolic process|benzaldehyde dehydrogenase (NADP+) activity|benzaldehyde dehydrogenase (NAD+) activity|sphingolipid biosynthetic process|secretory granule membrane|vesicle|cellular response to oxidative stress|specific granule membrane|neutrophil degranulation|aldehyde catabolic process|oxidation-reduction process|extracellular exosome "hsa00010,hsa00340,hsa00350,hsa00360,hsa00410,hsa00980,hsa00982,hsa05204" Glycolysis / Gluconeogenesis|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ALDH4A1 259.1769976 273.0231555 245.3308397 0.898571549 -0.154294712 0.761115308 1 4.143739784 3.883837657 8659 aldehyde dehydrogenase 4 family member A1 "GO:0003842,GO:0004029,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0006560,GO:0006562,GO:0009055,GO:0010133,GO:0019470,GO:0022900,GO:0042802,GO:0046487" 1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|proline metabolic process|proline catabolic process|electron transfer activity|proline catabolic process to glutamate|4-hydroxyproline catabolic process|electron transport chain|identical protein binding|glyoxylate metabolic process "hsa00250,hsa00330" "Alanine, aspartate and glutamate metabolism|Arginine and proline metabolism" ALDH5A1 128.2692044 113.6750685 142.8633404 1.256769337 0.329719887 0.602850513 1 1.113586305 1.459806816 7915 aldehyde dehydrogenase 5 family member A1 "GO:0004777,GO:0005739,GO:0005759,GO:0006105,GO:0006536,GO:0007417,GO:0009450,GO:0009791,GO:0042135,GO:0042802,GO:0055114" succinate-semialdehyde dehydrogenase (NAD+) activity|mitochondrion|mitochondrial matrix|succinate metabolic process|glutamate metabolic process|central nervous system development|gamma-aminobutyric acid catabolic process|post-embryonic development|neurotransmitter catabolic process|identical protein binding|oxidation-reduction process "hsa00250,hsa00650" "Alanine, aspartate and glutamate metabolism|Butanoate metabolism" ALDH6A1 525.458687 560.2556945 490.6616794 0.875781691 -0.191356806 0.637700953 1 5.13760175 4.693234207 4329 aldehyde dehydrogenase 6 family member A1 "GO:0000062,GO:0003723,GO:0004491,GO:0005654,GO:0005739,GO:0005759,GO:0006210,GO:0006573,GO:0006574,GO:0009083,GO:0018478,GO:0019859,GO:0050873,GO:0055114" fatty-acyl-CoA binding|RNA binding|methylmalonate-semialdehyde dehydrogenase (acylating) activity|nucleoplasm|mitochondrion|mitochondrial matrix|thymine catabolic process|valine metabolic process|valine catabolic process|branched-chain amino acid catabolic process|malonate-semialdehyde dehydrogenase (acetylating) activity|thymine metabolic process|brown fat cell differentiation|oxidation-reduction process "hsa00280,hsa00410,hsa00562,hsa00640" "Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Inositol phosphate metabolism|Propanoate metabolism" ALDH7A1 1125.804151 1222.006986 1029.601315 0.842549451 -0.247166731 0.474878573 1 12.98852946 11.41487903 501 aldehyde dehydrogenase 7 family member A1 "GO:0004029,GO:0004043,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0006081,GO:0006554,GO:0007605,GO:0008802,GO:0019285,GO:0042426,GO:0043878,GO:0055114,GO:0070062" aldehyde dehydrogenase (NAD+) activity|L-aminoadipate-semialdehyde dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial matrix|cytosol|cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound|betaine-aldehyde dehydrogenase activity|glycine betaine biosynthetic process from choline|choline catabolic process|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|oxidation-reduction process|extracellular exosome "hsa00010,hsa00053,hsa00071,hsa00260,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620" "Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Glycine, serine and threonine metabolism|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism" ALDH8A1 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.061621543 64577 aldehyde dehydrogenase 8 family member A1 "GO:0001758,GO:0005829,GO:0042573,GO:0042574,GO:0042904,GO:0047102,GO:0055114,GO:0070062,GO:0097053" retinal dehydrogenase activity|cytosol|retinoic acid metabolic process|retinal metabolic process|9-cis-retinoic acid biosynthetic process|aminomuconate-semialdehyde dehydrogenase activity|oxidation-reduction process|extracellular exosome|L-kynurenine catabolic process hsa00380 Tryptophan metabolism ALDH9A1 1518.059392 1398.609324 1637.50946 1.170812629 0.227510213 0.492346581 1 28.0755562 34.28717443 223 aldehyde dehydrogenase 9 family member A1 "GO:0004029,GO:0005737,GO:0005829,GO:0006081,GO:0019145,GO:0033737,GO:0042136,GO:0042445,GO:0043878,GO:0045329,GO:0047105,GO:0051289,GO:0055114,GO:0070062" aldehyde dehydrogenase (NAD+) activity|cytoplasm|cytosol|cellular aldehyde metabolic process|aminobutyraldehyde dehydrogenase activity|1-pyrroline dehydrogenase activity|neurotransmitter biosynthetic process|hormone metabolic process|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|carnitine biosynthetic process|4-trimethylammoniobutyraldehyde dehydrogenase activity|protein homotetramerization|oxidation-reduction process|extracellular exosome "hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620" "Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism" ALDOA 177.42034 207.0510175 147.7896625 0.713783802 -0.486440933 0.386935854 1 4.886488167 3.63814052 226 "aldolase, fructose-bisphosphate A" "GO:0002576,GO:0003723,GO:0003779,GO:0004332,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005829,GO:0006000,GO:0006094,GO:0006096,GO:0006754,GO:0006941,GO:0007015,GO:0007339,GO:0008092,GO:0008360,GO:0015629,GO:0015631,GO:0016020,GO:0030388,GO:0031093,GO:0031430,GO:0031674,GO:0034774,GO:0042802,GO:0043312,GO:0045296,GO:0046716,GO:0051289,GO:0061621,GO:0061827,GO:0070061,GO:0070062,GO:1904724,GO:1904813" "platelet degranulation|RNA binding|actin binding|fructose-bisphosphate aldolase activity|protein binding|extracellular region|extracellular space|nucleus|cytosol|fructose metabolic process|gluconeogenesis|glycolytic process|ATP biosynthetic process|striated muscle contraction|actin filament organization|binding of sperm to zona pellucida|cytoskeletal protein binding|regulation of cell shape|actin cytoskeleton|tubulin binding|membrane|fructose 1,6-bisphosphate metabolic process|platelet alpha granule lumen|M band|I band|secretory granule lumen|identical protein binding|neutrophil degranulation|cadherin binding|muscle cell cellular homeostasis|protein homotetramerization|canonical glycolysis|sperm head|fructose binding|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen" "hsa00010,hsa00030,hsa00051,hsa04066" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|HIF-1 signaling pathway ALDOC 836.4118009 1139.795552 533.0280494 0.467652333 -1.09649171 0.002841551 0.179136658 34.6498342 16.90208167 230 "aldolase, fructose-bisphosphate C" "GO:0004332,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0006000,GO:0006094,GO:0006096,GO:0008092,GO:0030388,GO:0030855,GO:0034774,GO:0043312,GO:0061621,GO:0070062,GO:1904724,GO:1904813" "fructose-bisphosphate aldolase activity|protein binding|extracellular region|cytosol|cytoskeleton|fructose metabolic process|gluconeogenesis|glycolytic process|cytoskeletal protein binding|fructose 1,6-bisphosphate metabolic process|epithelial cell differentiation|secretory granule lumen|neutrophil degranulation|canonical glycolysis|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen" "hsa00010,hsa00030,hsa00051,hsa04066" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|HIF-1 signaling pathway ALG1 534.5487534 575.4800341 493.6174727 0.857749085 -0.221372413 0.583590151 1 7.057150982 6.314014895 56052 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase "GO:0000030,GO:0004578,GO:0005783,GO:0005789,GO:0006486,GO:0006488,GO:0016020,GO:0016021,GO:0097502" mannosyltransferase activity|chitobiosyldiphosphodolichol beta-mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|integral component of membrane|mannosylation "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG10 337.5446128 343.0551173 332.0341084 0.967873941 -0.047108936 0.924326903 1 1.705057062 1.721367681 84920 "ALG10 alpha-1,2-glucosyltransferase" "GO:0005515,GO:0005783,GO:0005789,GO:0006487,GO:0006488,GO:0016021,GO:0106073" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity" hsa00510 N-Glycan biosynthesis ALG10B 530.7346267 483.1190409 578.3502125 1.197117405 0.259564649 0.520528586 1 2.412806931 3.012834296 144245 "ALG10 alpha-1,2-glucosyltransferase B" "GO:0005515,GO:0005783,GO:0005886,GO:0006486,GO:0006487,GO:0006488,GO:0016021,GO:0016740,GO:0060050,GO:0106073,GO:1901980" "protein binding|endoplasmic reticulum|plasma membrane|protein glycosylation|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|transferase activity|positive regulation of protein glycosylation|dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity|positive regulation of inward rectifier potassium channel activity" hsa00510 N-Glycan biosynthesis ALG11 110.6532111 121.7947162 99.51170607 0.817044525 -0.291513394 0.66401157 1 0.947538051 0.807529345 440138 "ALG11 alpha-1,2-mannosyltransferase" "GO:0004377,GO:0005789,GO:0006487,GO:0006490,GO:0016020,GO:0016021,GO:0097502" "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|oligosaccharide-lipid intermediate biosynthetic process|membrane|integral component of membrane|mannosylation" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG12 770.0551566 779.4861837 760.6241296 0.975801939 -0.035339745 0.927527443 1 7.201427461 7.329868731 79087 "ALG12 alpha-1,6-mannosyltransferase" "GO:0000009,GO:0000030,GO:0005783,GO:0005788,GO:0005789,GO:0006457,GO:0006487,GO:0006488,GO:0016020,GO:0016021,GO:0052824,GO:0052917,GO:0097502" "alpha-1,6-mannosyltransferase activity|mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein folding|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|integral component of membrane|dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity|dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity|mannosylation" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG13 737.4996152 742.9477688 732.0514615 0.985333683 -0.021315719 0.958402366 1 3.13485658 3.221936194 79868 ALG13 UDP-N-acetylglucosaminyltransferase subunit "GO:0003723,GO:0004577,GO:0004843,GO:0005789,GO:0006488,GO:0006508,GO:0008234,GO:0018215" RNA binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity|thiol-dependent ubiquitin-specific protease activity|endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|proteolysis|cysteine-type peptidase activity|protein phosphopantetheinylation "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG14 139.7630488 124.8395841 154.6865134 1.239082255 0.309271962 0.615639384 1 0.565838959 0.731322463 199857 ALG14 UDP-N-acetylglucosaminyltransferase subunit "GO:0005789,GO:0006488,GO:0016021,GO:0031965,GO:0043541" endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|nuclear membrane|UDP-N-acetylglucosamine transferase complex "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG2 866.1345208 948.9838304 783.2852112 0.825393633 -0.276845786 0.444603446 1 17.11634017 14.73628299 85365 "ALG2 alpha-1,3/1,6-mannosyltransferase" "GO:0000033,GO:0004378,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0006488,GO:0006490,GO:0015629,GO:0016020,GO:0016021,GO:0033577,GO:0046982,GO:0047485,GO:0048306,GO:0048471,GO:0051592,GO:0097502,GO:0102704" "alpha-1,3-mannosyltransferase activity|GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|actin cytoskeleton|membrane|integral component of membrane|protein glycosylation in endoplasmic reticulum|protein heterodimerization activity|protein N-terminus binding|calcium-dependent protein binding|perinuclear region of cytoplasm|response to calcium ion|mannosylation|GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG3 1116.518368 1227.081766 1005.954969 0.819794571 -0.28666566 0.407644184 1 27.78156574 23.756239 10195 "ALG3 alpha-1,3- mannosyltransferase" "GO:0000033,GO:0005515,GO:0005783,GO:0005789,GO:0006486,GO:0006488,GO:0016021,GO:0052925,GO:0097502" "alpha-1,3-mannosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity|mannosylation" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG5 328.9080845 257.798816 400.0173531 1.551664819 0.633816949 0.16821267 1 10.60649924 17.16666407 29880 ALG5 dolichyl-phosphate beta-glucosyltransferase "GO:0004576,GO:0004581,GO:0005789,GO:0006486,GO:0006487,GO:0007368,GO:0016020,GO:0016021,GO:0018279" oligosaccharyl transferase activity|dolichyl-phosphate beta-glucosyltransferase activity|endoplasmic reticulum membrane|protein glycosylation|protein N-linked glycosylation|determination of left/right symmetry|membrane|integral component of membrane|protein N-linked glycosylation via asparagine hsa00510 N-Glycan biosynthesis ALG6 376.5758803 418.161859 334.9899016 0.801101044 -0.319943872 0.469816225 1 6.369450517 5.322371627 29929 "ALG6 alpha-1,3-glucosyltransferase" "GO:0004583,GO:0005789,GO:0006487,GO:0006488,GO:0006490,GO:0016020,GO:0016021,GO:0042281,GO:0046527" "dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|membrane|integral component of membrane|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity|glucosyltransferase activity" hsa00510 N-Glycan biosynthesis ALG8 781.2439206 870.8322209 691.6556204 0.794246703 -0.332340898 0.36827821 1 17.55755568 14.54572608 79053 "ALG8 alpha-1,3-glucosyltransferase" "GO:0000033,GO:0004583,GO:0005515,GO:0005789,GO:0006487,GO:0006488,GO:0006490,GO:0016021,GO:0018279,GO:0042283,GO:0097502" "alpha-1,3-mannosyltransferase activity|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|protein binding|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|integral component of membrane|protein N-linked glycosylation via asparagine|dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity|mannosylation" hsa00510 N-Glycan biosynthesis ALG9 876.7606291 799.7853031 953.7359552 1.192489974 0.253977137 0.482299338 1 5.954182585 7.406155295 79796 "ALG9 alpha-1,2-mannosyltransferase" "GO:0000026,GO:0000030,GO:0005789,GO:0006487,GO:0006488,GO:0016020,GO:0016021,GO:0052918,GO:0052926,GO:0097502" "alpha-1,2-mannosyltransferase activity|mannosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|integral component of membrane|dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity|dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity|mannosylation" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALKAL1 8.015727316 9.134603715 6.896850916 0.755024644 -0.405404361 0.864587159 1 0.405820573 0.319603198 389658 ALK and LTK ligand 1 "GO:0005515,GO:0005576,GO:0010976,GO:0030298,GO:0030971,GO:0061098,GO:0070374,GO:0070378" protein binding|extracellular region|positive regulation of neuron projection development|receptor signaling protein tyrosine kinase activator activity|receptor tyrosine kinase binding|positive regulation of protein tyrosine kinase activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of ERK5 cascade ALKAL2 23.00253443 23.34398727 22.66108158 0.970745971 -0.042834281 1 1 0.790829835 0.800764057 285016 ALK and LTK ligand 2 "GO:0005515,GO:0005576,GO:0010976,GO:0030298,GO:0030971,GO:0061098,GO:0070374,GO:0070378" protein binding|extracellular region|positive regulation of neuron projection development|receptor signaling protein tyrosine kinase activator activity|receptor tyrosine kinase binding|positive regulation of protein tyrosine kinase activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of ERK5 cascade ALKBH1 325.2166835 308.5466144 341.8867525 1.108055433 0.148030058 0.752931757 1 6.017249723 6.954652794 8846 "alkB homolog 1, histone H2A dioxygenase" "GO:0000049,GO:0000791,GO:0001701,GO:0001764,GO:0001890,GO:0002101,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0006281,GO:0006307,GO:0006446,GO:0006448,GO:0008198,GO:0016706,GO:0031175,GO:0035511,GO:0035513,GO:0035515,GO:0035516,GO:0035552,GO:0042056,GO:0042245,GO:0043524,GO:0048589,GO:0050918,GO:0070129,GO:0070579,GO:0070989,GO:0080111,GO:0103053,GO:0140078,GO:1990983,GO:1990984" tRNA binding|euchromatin|in utero embryonic development|neuron migration|placenta development|tRNA wobble cytosine modification|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|DNA repair|DNA dealkylation involved in DNA repair|regulation of translational initiation|regulation of translational elongation|ferrous iron binding|2-oxoglutarate-dependent dioxygenase activity|neuron projection development|oxidative DNA demethylation|oxidative RNA demethylation|oxidative RNA demethylase activity|oxidative DNA demethylase activity|oxidative single-stranded DNA demethylation|chemoattractant activity|RNA repair|negative regulation of neuron apoptotic process|developmental growth|positive chemotaxis|regulation of mitochondrial translation|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|1-ethyladenine demethylase activity|class I DNA-(apurinic or apyrimidinic site) endonuclease activity|tRNA demethylation|tRNA demethylase activity ALKBH2 123.1026283 130.9293199 115.2759367 0.88044402 -0.183696817 0.781246263 1 5.619583189 5.160856486 121642 "alkB homolog 2, alpha-ketoglutarate dependent dioxygenase" "GO:0005515,GO:0005654,GO:0006307,GO:0008198,GO:0035511,GO:0043734,GO:0051747,GO:0070989,GO:0080111,GO:0103053" protein binding|nucleoplasm|DNA dealkylation involved in DNA repair|ferrous iron binding|oxidative DNA demethylation|DNA-N1-methyladenine dioxygenase activity|cytosine C-5 DNA demethylase activity|oxidative demethylation|DNA demethylation|1-ethyladenine demethylase activity ALKBH3 518.3297469 477.0293051 559.6301886 1.173156832 0.230395892 0.571219692 1 15.64757218 19.14780375 221120 "alkB homolog 3, alpha-ketoglutarate dependent dioxygenase" "GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006281,GO:0006307,GO:0008198,GO:0008283,GO:0031418,GO:0035552,GO:0035553,GO:0043734,GO:1990930" protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|DNA repair|DNA dealkylation involved in DNA repair|ferrous iron binding|cell population proliferation|L-ascorbic acid binding|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|DNA-N1-methyladenine dioxygenase activity|RNA N1-methyladenosine dioxygenase activity ALKBH4 294.2105459 310.5765263 277.8445655 0.894609032 -0.160670772 0.74047908 1 7.454789294 6.956400552 54784 "alkB homolog 4, lysine demethylase" "GO:0003779,GO:0005515,GO:0005730,GO:0005737,GO:0006325,GO:0006482,GO:0016491,GO:0016706,GO:0030496,GO:0031032,GO:0032451,GO:0035511,GO:0035516,GO:0036090,GO:0046872,GO:0070938,GO:0070989,GO:0080111,GO:1902275" actin binding|protein binding|nucleolus|cytoplasm|chromatin organization|protein demethylation|oxidoreductase activity|2-oxoglutarate-dependent dioxygenase activity|midbody|actomyosin structure organization|demethylase activity|oxidative DNA demethylation|oxidative DNA demethylase activity|cleavage furrow ingression|metal ion binding|contractile ring|oxidative demethylation|DNA demethylation|regulation of chromatin organization ALKBH5 2394.541665 2684.558536 2104.524794 0.783937011 -0.351190357 0.27167519 1 43.04001878 35.19407461 54890 "alkB homolog 5, RNA demethylase" "GO:0001666,GO:0003723,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006307,GO:0006397,GO:0006406,GO:0007283,GO:0016607,GO:0016706,GO:0030154,GO:0035515,GO:0035553,GO:0043488,GO:0046872,GO:1990931" response to hypoxia|RNA binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|DNA dealkylation involved in DNA repair|mRNA processing|mRNA export from nucleus|spermatogenesis|nuclear speck|2-oxoglutarate-dependent dioxygenase activity|cell differentiation|oxidative RNA demethylase activity|oxidative single-stranded RNA demethylation|regulation of mRNA stability|metal ion binding|RNA N6-methyladenosine dioxygenase activity ALKBH6 210.53334 180.6621624 240.4045176 1.330685488 0.412169625 0.438748272 1 5.718688241 7.937573715 84964 alkB homolog 6 "GO:0005515,GO:0005654,GO:0005737,GO:0005925,GO:0046872,GO:0051213,GO:0055114" protein binding|nucleoplasm|cytoplasm|focal adhesion|metal ion binding|dioxygenase activity|oxidation-reduction process ALKBH7 344.5156926 348.1298972 340.9014881 0.97923646 -0.03027082 0.95359644 1 19.18558342 19.59650016 84266 alkB homolog 7 "GO:0005515,GO:0005739,GO:0005759,GO:0006631,GO:0006974,GO:0010883,GO:0046872,GO:0051213,GO:0055114,GO:1902445" protein binding|mitochondrion|mitochondrial matrix|fatty acid metabolic process|cellular response to DNA damage stimulus|regulation of lipid storage|metal ion binding|dioxygenase activity|oxidation-reduction process|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death ALKBH8 346.5577287 386.698224 306.4172335 0.792393692 -0.335710699 0.459340916 1 4.151102343 3.430997332 91801 "alkB homolog 8, tRNA methyltransferase" "GO:0000049,GO:0002098,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006974,GO:0008270,GO:0016300,GO:0016604,GO:0016706,GO:0030488,GO:0055114,GO:0106335" tRNA binding|tRNA wobble uridine modification|iron ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cellular response to DNA damage stimulus|zinc ion binding|tRNA (uracil) methyltransferase activity|nuclear body|2-oxoglutarate-dependent dioxygenase activity|tRNA methylation|oxidation-reduction process|tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity ALMS1 1074.500378 981.4624214 1167.538334 1.18959046 0.250464983 0.472415354 1 3.846742706 4.773166034 7840 ALMS1 centrosome and basal body associated protein "GO:0000086,GO:0000922,GO:0003674,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0008017,GO:0010389,GO:0016197,GO:0046599,GO:0051492,GO:0097711,GO:0120162" G2/M transition of mitotic cell cycle|spindle pole|molecular_function|protein binding|centrosome|centriole|cytosol|cilium|microtubule binding|regulation of G2/M transition of mitotic cell cycle|endosomal transport|regulation of centriole replication|regulation of stress fiber assembly|ciliary basal body-plasma membrane docking|positive regulation of cold-induced thermogenesis ALOX5 4.956013635 2.029911937 7.882115332 3.882983882 1.957165719 0.335178207 1 0.040699873 0.164844541 240 arachidonate 5-lipoxygenase "GO:0001937,GO:0002232,GO:0002523,GO:0002540,GO:0004051,GO:0005506,GO:0005515,GO:0005576,GO:0005615,GO:0005635,GO:0005641,GO:0005654,GO:0005829,GO:0006691,GO:0006959,GO:0016363,GO:0016525,GO:0016702,GO:0016787,GO:0019221,GO:0019369,GO:0019370,GO:0019372,GO:0030501,GO:0031965,GO:0034440,GO:0034774,GO:0035655,GO:0036336,GO:0042593,GO:0042759,GO:0043312,GO:0043651,GO:0045598,GO:0048471,GO:0050727,GO:0050728,GO:0050796,GO:0051122,GO:0061044,GO:0061045,GO:0106014,GO:1900015,GO:1900407,GO:1901753,GO:1903426,GO:1903573,GO:1903671,GO:1904813,GO:1904999,GO:2001301" "negative regulation of endothelial cell proliferation|leukocyte chemotaxis involved in inflammatory response|leukocyte migration involved in inflammatory response|leukotriene production involved in inflammatory response|arachidonate 5-lipoxygenase activity|iron ion binding|protein binding|extracellular region|extracellular space|nuclear envelope|nuclear envelope lumen|nucleoplasm|cytosol|leukotriene metabolic process|humoral immune response|nuclear matrix|negative regulation of angiogenesis|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|hydrolase activity|cytokine-mediated signaling pathway|arachidonic acid metabolic process|leukotriene biosynthetic process|lipoxygenase pathway|positive regulation of bone mineralization|nuclear membrane|lipid oxidation|secretory granule lumen|interleukin-18-mediated signaling pathway|dendritic cell migration|glucose homeostasis|long-chain fatty acid biosynthetic process|neutrophil degranulation|linoleic acid metabolic process|regulation of fat cell differentiation|perinuclear region of cytoplasm|regulation of inflammatory response|negative regulation of inflammatory response|regulation of insulin secretion|hepoxilin biosynthetic process|negative regulation of vascular wound healing|negative regulation of wound healing|regulation of inflammatory response to wounding|regulation of cytokine production involved in inflammatory response|regulation of cellular response to oxidative stress|leukotriene A4 biosynthetic process|regulation of reactive oxygen species biosynthetic process|negative regulation of response to endoplasmic reticulum stress|negative regulation of sprouting angiogenesis|ficolin-1-rich granule lumen|positive regulation of leukocyte adhesion to arterial endothelial cell|lipoxin biosynthetic process" "hsa00590,hsa04664,hsa04726,hsa04913,hsa05145" Arachidonic acid metabolism|Fc epsilon RI signaling pathway|Serotonergic synapse|Ovarian steroidogenesis|Toxoplasmosis ALOX5AP 325.1503733 573.4501221 76.85062449 0.134014488 -2.89953912 6.46E-09 4.22E-06 21.62563341 3.022988659 241 arachidonate 5-lipoxygenase activating protein "GO:0004364,GO:0004464,GO:0004602,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0006691,GO:0008047,GO:0016020,GO:0016021,GO:0019370,GO:0019372,GO:0031965,GO:0047485,GO:0050544,GO:0050790,GO:0070207,GO:0071277,GO:0098869,GO:2001301" glutathione transferase activity|leukotriene-C4 synthase activity|glutathione peroxidase activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|leukotriene metabolic process|enzyme activator activity|membrane|integral component of membrane|leukotriene biosynthetic process|lipoxygenase pathway|nuclear membrane|protein N-terminus binding|arachidonic acid binding|regulation of catalytic activity|protein homotrimerization|cellular response to calcium ion|cellular oxidant detoxification|lipoxin biosynthetic process hsa04664 Fc epsilon RI signaling pathway ALOXE3 8.5232053 10.14955968 6.896850916 0.679522179 -0.557407454 0.765908482 1 0.143386162 0.101631143 59344 arachidonate lipoxygenase 3 "GO:0005506,GO:0005515,GO:0005829,GO:0006665,GO:0016702,GO:0019233,GO:0019369,GO:0019372,GO:0035357,GO:0043651,GO:0045444,GO:0046513,GO:0050486,GO:0051120,GO:0051122,GO:0055114,GO:0061436,GO:0106255,GO:0106256" "iron ion binding|protein binding|cytosol|sphingolipid metabolic process|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sensory perception of pain|arachidonic acid metabolic process|lipoxygenase pathway|peroxisome proliferator activated receptor signaling pathway|linoleic acid metabolic process|fat cell differentiation|ceramide biosynthetic process|intramolecular transferase activity, transferring hydroxy groups|hepoxilin A3 synthase activity|hepoxilin biosynthetic process|oxidation-reduction process|establishment of skin barrier|hydroperoxy icosatetraenoate isomerase activity|hydroperoxy icosatetraenoate dehydratase activity" ALPK1 290.1682894 269.9782876 310.3582912 1.149567597 0.201091302 0.678058302 1 2.532588968 3.036792752 80216 alpha kinase 1 "GO:0002753,GO:0004674,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0043123,GO:0045087,GO:0048029,GO:0106310,GO:0106311" cytoplasmic pattern recognition receptor signaling pathway|protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|monosaccharide binding|protein serine kinase activity|protein threonine kinase activity ALPK2 36.36298715 27.40381115 45.32216316 1.653863505 0.725840173 0.443675802 1 0.186621804 0.321942252 115701 alpha kinase 2 "GO:0003007,GO:0003308,GO:0005524,GO:0006468,GO:0010468,GO:0016323,GO:0030010,GO:0042981,GO:0055013,GO:0106310,GO:0106311,GO:1905223" heart morphogenesis|negative regulation of Wnt signaling pathway involved in heart development|ATP binding|protein phosphorylation|regulation of gene expression|basolateral plasma membrane|establishment of cell polarity|regulation of apoptotic process|cardiac muscle cell development|protein serine kinase activity|protein threonine kinase activity|epicardium morphogenesis ALPK3 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.020083586 0.005083968 57538 alpha kinase 3 "GO:0005524,GO:0005634,GO:0006468,GO:0007507,GO:0055013,GO:0106310,GO:0106311" ATP binding|nucleus|protein phosphorylation|heart development|cardiac muscle cell development|protein serine kinase activity|protein threonine kinase activity ALS2 788.7482106 743.9627248 833.5336964 1.120397123 0.164010184 0.657958987 1 3.431923442 4.010749203 57679 alsin Rho guanine nucleotide exchange factor ALS2 "GO:0001726,GO:0005085,GO:0005096,GO:0005515,GO:0005634,GO:0005769,GO:0005813,GO:0005829,GO:0007032,GO:0007041,GO:0030027,GO:0030425,GO:0030426,GO:0031267,GO:0031982,GO:0032991,GO:0035022,GO:0042802,GO:0042803,GO:0043539,GO:0043547,GO:0045860,GO:0048812,GO:0051036,GO:0051260,GO:0071902" ruffle|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleus|early endosome|centrosome|cytosol|endosome organization|lysosomal transport|lamellipodium|dendrite|growth cone|small GTPase binding|vesicle|protein-containing complex|positive regulation of Rac protein signal transduction|identical protein binding|protein homodimerization activity|protein serine/threonine kinase activator activity|positive regulation of GTPase activity|positive regulation of protein kinase activity|neuron projection morphogenesis|regulation of endosome size|protein homooligomerization|positive regulation of protein serine/threonine kinase activity "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases ALS2CL 277.3707384 136.0040998 418.737377 3.078858489 1.622395559 0.001061688 0.094053034 0.924953385 2.970472281 259173 ALS2 C-terminal like "GO:0005096,GO:0005515,GO:0005829,GO:0007032,GO:0042802,GO:0043547" GTPase activator activity|protein binding|cytosol|endosome organization|identical protein binding|positive regulation of GTPase activity ALYREF 1011.3044 1039.314912 983.2938877 0.946098124 -0.079938276 0.822477191 1 47.98325779 47.35238321 10189 Aly/REF export factor "GO:0000018,GO:0000346,GO:0000398,GO:0000781,GO:0001649,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0016020,GO:0016032,GO:0016607,GO:0031124,GO:0031297,GO:0032786,GO:0035145,GO:0046784,GO:0062153,GO:0070062,GO:0071013" "regulation of DNA recombination|transcription export complex|mRNA splicing, via spliceosome|chromosome, telomeric region|osteoblast differentiation|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|membrane|viral process|nuclear speck|mRNA 3'-end processing|replication fork processing|positive regulation of DNA-templated transcription, elongation|exon-exon junction complex|viral mRNA export from host cell nucleus|C5-methylcytidine-containing RNA binding|extracellular exosome|catalytic step 2 spliceosome" "hsa03013,hsa03015,hsa03040,hsa05014,hsa05168" RNA transport|mRNA surveillance pathway|Spliceosome|Amyotrophic lateral sclerosis|Herpes simplex virus 1 infection AMACR 239.3974804 267.9483757 210.8465851 0.786892567 -0.345761414 0.498738155 1 3.303466398 2.711447915 23600 alpha-methylacyl-CoA racemase "GO:0005737,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0005886,GO:0006625,GO:0006699,GO:0008111,GO:0008206,GO:0008410,GO:0033540,GO:0043231" cytoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|plasma membrane|protein targeting to peroxisome|bile acid biosynthetic process|alpha-methylacyl-CoA racemase activity|bile acid metabolic process|CoA-transferase activity|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular membrane-bounded organelle "hsa00120,hsa04146" Primary bile acid biosynthesis|Peroxisome AMBRA1 1179.411987 1215.91725 1142.906723 0.939954362 -0.089337384 0.796352207 1 9.751689504 9.560983357 55626 autophagy and beclin 1 regulator 1 "GO:0000045,GO:0000422,GO:0000423,GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0005776,GO:0005829,GO:0005930,GO:0006914,GO:0008285,GO:0009267,GO:0010508,GO:0010667,GO:0016236,GO:0021915,GO:0030154,GO:0031625,GO:0043231,GO:0043524,GO:0043552,GO:0045335,GO:0048471,GO:0051020,GO:0098780" autophagosome assembly|autophagy of mitochondrion|mitophagy|protein binding|cytoplasm|mitochondrion|mitochondrial outer membrane|autophagosome|cytosol|axoneme|autophagy|negative regulation of cell population proliferation|cellular response to starvation|positive regulation of autophagy|negative regulation of cardiac muscle cell apoptotic process|macroautophagy|neural tube development|cell differentiation|ubiquitin protein ligase binding|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|phagocytic vesicle|perinuclear region of cytoplasm|GTPase binding|response to mitochondrial depolarisation "hsa04137,hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Mitophagy - animal|Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases AMD1 1617.600544 1771.098165 1464.102923 0.826663904 -0.274627202 0.403483773 1 24.28258635 20.93822422 262 adenosylmethionine decarboxylase 1 "GO:0004014,GO:0005515,GO:0005829,GO:0006557,GO:0006595,GO:0006597,GO:0008295,GO:0019810,GO:0042802" adenosylmethionine decarboxylase activity|protein binding|cytosol|S-adenosylmethioninamine biosynthetic process|polyamine metabolic process|spermine biosynthetic process|spermidine biosynthetic process|putrescine binding|identical protein binding "hsa00270,hsa00330" Cysteine and methionine metabolism|Arginine and proline metabolism AMDHD1 46.63131304 55.82257826 37.44004783 0.670697216 -0.576266481 0.5136145 1 1.270088346 0.888538734 144193 amidohydrolase domain containing 1 "GO:0003674,GO:0005829,GO:0006548,GO:0016812,GO:0019556,GO:0019557,GO:0046872,GO:0050480" "molecular_function|cytosol|histidine catabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate|metal ion binding|imidazolonepropionase activity" hsa00340 Histidine metabolism AMDHD2 464.6989002 582.5847258 346.8130746 0.595300665 -0.748309589 0.072815303 1 9.006673116 5.592637859 51005 amidohydrolase domain containing 2 "GO:0005515,GO:0005634,GO:0005829,GO:0005975,GO:0006046,GO:0006048,GO:0008448,GO:0019262,GO:0046872,GO:0047419" protein binding|nucleus|cytosol|carbohydrate metabolic process|N-acetylglucosamine catabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylglucosamine-6-phosphate deacetylase activity|N-acetylneuraminate catabolic process|metal ion binding|N-acetylgalactosamine-6-phosphate deacetylase activity hsa00520 Amino sugar and nucleotide sugar metabolism AMER1 355.7720045 343.0551173 368.4888918 1.074139032 0.103180742 0.823387928 1 2.066674374 2.315519713 139285 APC membrane recruitment protein 1 "GO:0005515,GO:0005546,GO:0005829,GO:0005886,GO:0008013,GO:0016055,GO:0016604,GO:0031398,GO:0043231,GO:0060348,GO:0060612,GO:0060828,GO:0072161,GO:0090090,GO:0090263,GO:1903364,GO:1904713,GO:1904885,GO:1904886" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|beta-catenin binding|Wnt signaling pathway|nuclear body|positive regulation of protein ubiquitination|intracellular membrane-bounded organelle|bone development|adipose tissue development|regulation of canonical Wnt signaling pathway|mesenchymal cell differentiation involved in kidney development|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of cellular protein catabolic process|beta-catenin destruction complex binding|beta-catenin destruction complex assembly|beta-catenin destruction complex disassembly" AMFR 2054.446546 1762.978517 2345.914576 1.330654091 0.412135585 0.200340606 1 20.72624013 28.76746734 267 autocrine motility factor receptor "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006457,GO:0006511,GO:0007165,GO:0007568,GO:0007611,GO:0016020,GO:0016021,GO:0016055,GO:0016567,GO:0030176,GO:0030425,GO:0030426,GO:0030433,GO:0030674,GO:0030968,GO:0032092,GO:0032991,GO:0034450,GO:0036513,GO:0038023,GO:0042802,GO:0043025,GO:0043130,GO:0044322,GO:0046872,GO:0048471,GO:0051087,GO:0051865,GO:0061630,GO:0070936,GO:0090090,GO:1904288,GO:1904380,GO:1990381,GO:2000638" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein folding|ubiquitin-dependent protein catabolic process|signal transduction|aging|learning or memory|membrane|integral component of membrane|Wnt signaling pathway|protein ubiquitination|integral component of endoplasmic reticulum membrane|dendrite|growth cone|ubiquitin-dependent ERAD pathway|protein-macromolecule adaptor activity|endoplasmic reticulum unfolded protein response|positive regulation of protein binding|protein-containing complex|ubiquitin-ubiquitin ligase activity|Derlin-1 retrotranslocation complex|signaling receptor activity|identical protein binding|neuronal cell body|ubiquitin binding|endoplasmic reticulum quality control compartment|metal ion binding|perinuclear region of cytoplasm|chaperone binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of canonical Wnt signaling pathway|BAT3 complex binding|endoplasmic reticulum mannose trimming|ubiquitin-specific protease binding|regulation of SREBP signaling pathway hsa04141 Protein processing in endoplasmic reticulum AMH 151.1084353 125.8545401 176.3623306 1.40131878 0.486785186 0.412191467 1 3.523542547 5.150298399 268 anti-Mullerian hormone "GO:0001546,GO:0001655,GO:0001880,GO:0005102,GO:0005160,GO:0005179,GO:0005576,GO:0005615,GO:0007267,GO:0007506,GO:0007530,GO:0007548,GO:0007568,GO:0008083,GO:0010628,GO:0014070,GO:0030509,GO:0042493,GO:0051092,GO:2000355" preantral ovarian follicle growth|urogenital system development|Mullerian duct regression|signaling receptor binding|transforming growth factor beta receptor binding|hormone activity|extracellular region|extracellular space|cell-cell signaling|gonadal mesoderm development|sex determination|sex differentiation|aging|growth factor activity|positive regulation of gene expression|response to organic cyclic compound|BMP signaling pathway|response to drug|positive regulation of NF-kappaB transcription factor activity|negative regulation of ovarian follicle development "hsa04024,hsa04060,hsa04350,hsa04390" cAMP signaling pathway|Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway AMIGO1 260.1771078 274.0381115 246.3161041 0.898838862 -0.153865594 0.761470409 1 2.705470487 2.536533319 57463 adhesion molecule with Ig like domain 1 "GO:0005515,GO:0007156,GO:0007157,GO:0007409,GO:0007413,GO:0007420,GO:0008076,GO:0010976,GO:0015459,GO:0016021,GO:0030425,GO:0032809,GO:0042552,GO:0043204,GO:0050772,GO:0051965,GO:1901381,GO:1903818,GO:1905232,GO:1990030" protein binding|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axonogenesis|axonal fasciculation|brain development|voltage-gated potassium channel complex|positive regulation of neuron projection development|potassium channel regulator activity|integral component of membrane|dendrite|neuronal cell body membrane|myelination|perikaryon|positive regulation of axonogenesis|positive regulation of synapse assembly|positive regulation of potassium ion transmembrane transport|positive regulation of voltage-gated potassium channel activity|cellular response to L-glutamate|pericellular basket AMIGO2 2173.73208 2205.499319 2141.964842 0.971192701 -0.042170515 0.896698792 1 28.23578362 28.60363218 347902 adhesion molecule with Ig like domain 2 "GO:0005515,GO:0005634,GO:0005886,GO:0007156,GO:0007157,GO:0007420,GO:0016021,GO:0043066,GO:0043069,GO:0051965" protein binding|nucleus|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|brain development|integral component of membrane|negative regulation of apoptotic process|negative regulation of programmed cell death|positive regulation of synapse assembly AMIGO3 293.1307636 371.4738844 214.7876428 0.578203884 -0.790349795 0.097680782 1 6.58747961 3.972978532 386724 adhesion molecule with Ig like domain 3 "GO:0007157,GO:0007420,GO:0016021,GO:0051965" heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|brain development|integral component of membrane|positive regulation of synapse assembly AMMECR1 422.328571 447.5955821 397.0615599 0.887098925 -0.172833098 0.688984309 1 3.881701577 3.5917833 9949 AMMECR nuclear protein 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0008150" protein binding|nucleus|nucleoplasm|mitochondrion|biological_process AMMECR1L 906.5452076 949.9987864 863.0916289 0.908518665 -0.138411941 0.701325395 1 7.26579389 6.885458382 83607 AMMECR1 like GO:0005634 nucleus AMN1 86.44272566 83.22638941 89.65906191 1.07729126 0.107408354 0.895728137 1 0.688295725 0.773435565 196394 antagonist of mitotic exit network 1 homolog "GO:0019005,GO:0031146" SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process AMOT 409.9412585 409.0272553 410.8552617 1.004469156 0.006433264 0.99455409 1 2.610027405 2.734623884 154796 angiomotin "GO:0001525,GO:0001570,GO:0001701,GO:0001702,GO:0001726,GO:0003365,GO:0005515,GO:0005654,GO:0005829,GO:0005884,GO:0005886,GO:0005923,GO:0006935,GO:0008180,GO:0009897,GO:0016525,GO:0030027,GO:0030036,GO:0030054,GO:0030139,GO:0030334,GO:0031410,GO:0034260,GO:0034613,GO:0035329,GO:0038023,GO:0040019,GO:0042074,GO:0043532,GO:0043534,GO:0051056" angiogenesis|vasculogenesis|in utero embryonic development|gastrulation with mouth forming second|ruffle|establishment of cell polarity involved in ameboidal cell migration|protein binding|nucleoplasm|cytosol|actin filament|plasma membrane|bicellular tight junction|chemotaxis|COP9 signalosome|external side of plasma membrane|negative regulation of angiogenesis|lamellipodium|actin cytoskeleton organization|cell junction|endocytic vesicle|regulation of cell migration|cytoplasmic vesicle|negative regulation of GTPase activity|cellular protein localization|hippo signaling|signaling receptor activity|positive regulation of embryonic development|cell migration involved in gastrulation|angiostatin binding|blood vessel endothelial cell migration|regulation of small GTPase mediated signal transduction "hsa04390,hsa04530" Hippo signaling pathway|Tight junction AMOTL1 2139.604371 1859.399334 2419.809407 1.30139307 0.380056776 0.236449382 1 9.348954304 12.6907549 154810 angiomotin like 1 "GO:0001525,GO:0003365,GO:0005515,GO:0005829,GO:0005886,GO:0005923,GO:0008180,GO:0016055,GO:0030036,GO:0030334,GO:0031410,GO:0035329,GO:0042802" angiogenesis|establishment of cell polarity involved in ameboidal cell migration|protein binding|cytosol|plasma membrane|bicellular tight junction|COP9 signalosome|Wnt signaling pathway|actin cytoskeleton organization|regulation of cell migration|cytoplasmic vesicle|hippo signaling|identical protein binding hsa04530 Tight junction AMOTL2 1844.949689 1686.856819 2003.042559 1.187440769 0.247855552 0.444966263 1 15.32711644 18.98402697 51421 angiomotin like 2 "GO:0001525,GO:0003365,GO:0005515,GO:0005829,GO:0005886,GO:0005923,GO:0016055,GO:0030036,GO:0030334,GO:0031410,GO:0035329,GO:0055037" angiogenesis|establishment of cell polarity involved in ameboidal cell migration|protein binding|cytosol|plasma membrane|bicellular tight junction|Wnt signaling pathway|actin cytoskeleton organization|regulation of cell migration|cytoplasmic vesicle|hippo signaling|recycling endosome hsa04530 Tight junction AMPD2 1478.342252 1680.767084 1275.917419 0.759128039 -0.397584856 0.231415354 1 20.55164737 16.27337385 271 adenosine monophosphate deaminase 2 "GO:0003876,GO:0005515,GO:0005829,GO:0006188,GO:0032264,GO:0043101,GO:0046033,GO:0046872,GO:0052652,GO:0097009" AMP deaminase activity|protein binding|cytosol|IMP biosynthetic process|IMP salvage|purine-containing compound salvage|AMP metabolic process|metal ion binding|cyclic purine nucleotide metabolic process|energy homeostasis hsa00230 Purine metabolism AMPD3 1210.341174 1242.306105 1178.376242 0.948539363 -0.07622045 0.825394175 1 11.84681259 11.72121969 272 adenosine monophosphate deaminase 3 "GO:0003876,GO:0005515,GO:0005576,GO:0005829,GO:0006188,GO:0006196,GO:0032264,GO:0034774,GO:0043101,GO:0043312,GO:0046033,GO:0046872,GO:1904813" AMP deaminase activity|protein binding|extracellular region|cytosol|IMP biosynthetic process|AMP catabolic process|IMP salvage|secretory granule lumen|purine-containing compound salvage|neutrophil degranulation|AMP metabolic process|metal ion binding|ficolin-1-rich granule lumen hsa00230 Purine metabolism AMT 37.85572955 28.41876711 47.29269199 1.664135949 0.734773297 0.432013437 1 0.720736254 1.251068532 275 aminomethyltransferase "GO:0004047,GO:0005654,GO:0005739,GO:0005759,GO:0006546,GO:0008483,GO:0019464" aminomethyltransferase activity|nucleoplasm|mitochondrion|mitochondrial matrix|glycine catabolic process|transaminase activity|glycine decarboxylation via glycine cleavage system "hsa00260,hsa00630,hsa00670" "Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism|One carbon pool by folate" AMTN 5.582257826 11.16451565 0 0 #NAME? 0.027998048 0.739737908 0.560399734 0 401138 amelotin "GO:0003674,GO:0005515,GO:0005604,GO:0005788,GO:0005911,GO:0007155,GO:0031012,GO:0031214,GO:0042475,GO:0043687,GO:0044267,GO:0070169,GO:0070175" molecular_function|protein binding|basement membrane|endoplasmic reticulum lumen|cell-cell junction|cell adhesion|extracellular matrix|biomineral tissue development|odontogenesis of dentin-containing tooth|post-translational protein modification|cellular protein metabolic process|positive regulation of biomineral tissue development|positive regulation of enamel mineralization AMY2B 14.4941749 14.20938356 14.77896625 1.040084968 0.056701392 1 1 0.282328423 0.306294608 280 amylase alpha 2B "GO:0004556,GO:0005975,GO:0046872,GO:0070062,GO:0103025" alpha-amylase activity|carbohydrate metabolic process|metal ion binding|extracellular exosome|alpha-amylase activity (releasing maltohexaose) "hsa00500,hsa04970,hsa04972,hsa04973" Starch and sucrose metabolism|Salivary secretion|Pancreatic secretion|Carbohydrate digestion and absorption AMZ1 28.94381248 25.37389921 32.51372575 1.281384681 0.357703648 0.743959478 1 0.083393802 0.111462615 155185 archaelysin family metallopeptidase 1 "GO:0005575,GO:0006508,GO:0008237,GO:0046872" cellular_component|proteolysis|metallopeptidase activity|metal ion binding AMZ2 1270.261432 1263.620181 1276.902684 1.010511468 0.015085695 0.967048118 1 30.72390992 32.38423628 51321 archaelysin family metallopeptidase 2 "GO:0005575,GO:0006508,GO:0008237,GO:0046872" cellular_component|proteolysis|metallopeptidase activity|metal ion binding ANAPC1 1429.791874 1359.026042 1500.557706 1.104141981 0.1429257 0.669353823 1 7.368576668 8.48641878 64682 anaphase promoting complex subunit 1 "GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007091,GO:0031145,GO:0051301,GO:0060090,GO:0070979,GO:1901990" nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|metaphase/anaphase transition of mitotic cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|molecular adaptor activity|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC10 180.197984 194.8715459 165.524422 0.849402724 -0.235479359 0.678531717 1 2.382799695 2.111140392 10393 anaphase promoting complex subunit 10 "GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0031145,GO:0051301,GO:0070979,GO:1901990" nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC11 797.4522868 732.7982092 862.1063645 1.176458067 0.234449899 0.524618879 1 27.73814958 34.03845721 51529 anaphase promoting complex subunit 11 "GO:0000278,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005680,GO:0005730,GO:0005829,GO:0006511,GO:0008270,GO:0016567,GO:0031145,GO:0031461,GO:0034450,GO:0045842,GO:0051301,GO:0061630,GO:0070979,GO:0097602,GO:1901990" mitotic cell cycle|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|anaphase-promoting complex|nucleolus|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|cullin-RING ubiquitin ligase complex|ubiquitin-ubiquitin ligase activity|positive regulation of mitotic metaphase/anaphase transition|cell division|ubiquitin protein ligase activity|protein K11-linked ubiquitination|cullin family protein binding|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC13 635.8973763 566.3454304 705.4493222 1.245616693 0.316860184 0.412104303 1 15.57187736 20.23211684 25847 anaphase promoting complex subunit 13 "GO:0005515,GO:0005680,GO:0007049,GO:0051301,GO:0070979" protein binding|anaphase-promoting complex|cell cycle|cell division|protein K11-linked ubiquitination "hsa04110,hsa04114,hsa04120,hsa04914" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation ANAPC15 480.9045448 478.0442611 483.7648285 1.011966606 0.017161683 0.972393317 1 6.439163666 6.796910872 25906 anaphase promoting complex subunit 15 "GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0031145,GO:0051301,GO:0090266,GO:1901990" protein binding|nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|regulation of mitotic cell cycle spindle assembly checkpoint|regulation of mitotic cell cycle phase transition ANAPC16 1380.918603 1520.404041 1241.433165 0.816515302 -0.292448171 0.383059061 1 22.05760556 18.78618627 119504 anaphase promoting complex subunit 16 "GO:0000776,GO:0000777,GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0016567,GO:0031145,GO:0051301,GO:1901990" kinetochore|condensed chromosome kinetochore|protein binding|nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|cell division|regulation of mitotic cell cycle phase transition ANAPC2 870.7099875 857.6377933 883.7821816 1.030484184 0.043322362 0.907691234 1 16.36019912 17.58514062 29882 anaphase promoting complex subunit 2 "GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0010629,GO:0031145,GO:0031625,GO:0031915,GO:0045773,GO:0050775,GO:0051301,GO:0070979,GO:0090129,GO:1901990" protein binding|nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|negative regulation of gene expression|anaphase-promoting complex-dependent catabolic process|ubiquitin protein ligase binding|positive regulation of synaptic plasticity|positive regulation of axon extension|positive regulation of dendrite morphogenesis|cell division|protein K11-linked ubiquitination|positive regulation of synapse maturation|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC4 234.0406308 238.5146526 229.5666091 0.962484303 -0.055165083 0.922708083 1 4.624780139 4.643021303 29945 anaphase promoting complex subunit 4 "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0019903,GO:0031145,GO:0034399,GO:0045842,GO:0051301,GO:0070979,GO:1901990" ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|nuclear periphery|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC5 2350.042947 2471.417783 2228.66811 0.90177716 -0.149157124 0.641226759 1 48.51495817 45.63424004 51433 anaphase promoting complex subunit 5 "GO:0005634,GO:0005654,GO:0005680,GO:0005819,GO:0005829,GO:0006511,GO:0007049,GO:0019903,GO:0031145,GO:0045842,GO:0051301,GO:0070979,GO:1901990" nucleus|nucleoplasm|anaphase-promoting complex|spindle|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04657,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|IL-17 signaling pathway|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC7 1277.903294 1280.874432 1274.932155 0.995360765 -0.006708574 0.986804812 1 12.93296877 13.42748502 51434 anaphase promoting complex subunit 7 "GO:0005634,GO:0005654,GO:0005680,GO:0005737,GO:0005819,GO:0005829,GO:0006511,GO:0007091,GO:0015630,GO:0016567,GO:0019903,GO:0031145,GO:0045842,GO:0051301,GO:0070979,GO:1901990" nucleus|nucleoplasm|anaphase-promoting complex|cytoplasm|spindle|cytosol|ubiquitin-dependent protein catabolic process|metaphase/anaphase transition of mitotic cell cycle|microtubule cytoskeleton|protein ubiquitination|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANG 66.54444224 70.03196182 63.05692266 0.90040206 -0.151358738 0.862645102 1 2.471687671 2.32137873 283 angiogenin "GO:0001525,GO:0001541,GO:0001556,GO:0001666,GO:0001890,GO:0001938,GO:0003677,GO:0003779,GO:0004519,GO:0004540,GO:0005102,GO:0005507,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005634,GO:0005694,GO:0005730,GO:0006651,GO:0007154,GO:0007202,GO:0008201,GO:0009303,GO:0009725,GO:0015629,GO:0016477,GO:0017148,GO:0019731,GO:0019843,GO:0030041,GO:0030426,GO:0031410,GO:0032148,GO:0032311,GO:0032431,GO:0034332,GO:0042277,GO:0042327,GO:0042592,GO:0042803,GO:0043025,GO:0045087,GO:0048662,GO:0050714,GO:0050830,GO:0061844,GO:0090501" angiogenesis|ovarian follicle development|oocyte maturation|response to hypoxia|placenta development|positive regulation of endothelial cell proliferation|DNA binding|actin binding|endonuclease activity|ribonuclease activity|signaling receptor binding|copper ion binding|protein binding|extracellular region|basement membrane|extracellular space|nucleus|chromosome|nucleolus|diacylglycerol biosynthetic process|cell communication|activation of phospholipase C activity|heparin binding|rRNA transcription|response to hormone|actin cytoskeleton|cell migration|negative regulation of translation|antibacterial humoral response|rRNA binding|actin filament polymerization|growth cone|cytoplasmic vesicle|activation of protein kinase B activity|angiogenin-PRI complex|activation of phospholipase A2 activity|adherens junction organization|peptide binding|positive regulation of phosphorylation|homeostatic process|protein homodimerization activity|neuronal cell body|innate immune response|negative regulation of smooth muscle cell proliferation|positive regulation of protein secretion|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|RNA phosphodiester bond hydrolysis hsa05014 Amyotrophic lateral sclerosis ANGEL1 506.5362654 479.0592171 534.0133138 1.114712534 0.156671711 0.703443112 1 4.455133919 5.1801171 23357 angel homolog 1 "GO:0000175,GO:0005634,GO:0005783,GO:0005801,GO:0005829,GO:0008190,GO:0019904,GO:0048471,GO:0090503" "3'-5'-exoribonuclease activity|nucleus|endoplasmic reticulum|cis-Golgi network|cytosol|eukaryotic initiation factor 4E binding|protein domain specific binding|perinuclear region of cytoplasm|RNA phosphodiester bond hydrolysis, exonucleolytic" ANGEL2 779.9699055 750.0524606 809.8873504 1.079774273 0.110729748 0.766755193 1 7.143195018 8.045284612 90806 angel homolog 2 "GO:0000175,GO:0003730,GO:0005737,GO:0015030,GO:0045930,GO:0070935,GO:0090503" "3'-5'-exoribonuclease activity|mRNA 3'-UTR binding|cytoplasm|Cajal body|negative regulation of mitotic cell cycle|3'-UTR-mediated mRNA stabilization|RNA phosphodiester bond hydrolysis, exonucleolytic" ANGPTL2 86.0391681 89.31612522 82.76221099 0.926621154 -0.109948477 0.8930266 1 0.540383067 0.522299815 23452 angiopoietin like 2 "GO:0001525,GO:0005102,GO:0005515,GO:0005615,GO:0007275,GO:0062023,GO:0070062" angiogenesis|signaling receptor binding|protein binding|extracellular space|multicellular organism development|collagen-containing extracellular matrix|extracellular exosome ANGPTL4 1031.210356 1692.946555 369.4741562 0.218243249 -2.195991069 2.08E-09 1.56E-06 43.85768321 9.983950839 51129 angiopoietin like 4 "GO:0001525,GO:0001666,GO:0004857,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0006629,GO:0019216,GO:0042802,GO:0043066,GO:0043335,GO:0045766,GO:0051005,GO:0062023,GO:0070328,GO:0072562,GO:2000352" angiogenesis|response to hypoxia|enzyme inhibitor activity|signaling receptor binding|protein binding|extracellular region|extracellular space|lipid metabolic process|regulation of lipid metabolic process|identical protein binding|negative regulation of apoptotic process|protein unfolding|positive regulation of angiogenesis|negative regulation of lipoprotein lipase activity|collagen-containing extracellular matrix|triglyceride homeostasis|blood microparticle|negative regulation of endothelial cell apoptotic process "hsa03320,hsa04979" PPAR signaling pathway|Cholesterol metabolism ANGPTL6 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.106352978 0.03589632 83854 angiopoietin like 6 "GO:0001525,GO:0005102,GO:0005615,GO:0030141,GO:0030154,GO:0062023,GO:0070062" angiogenesis|signaling receptor binding|extracellular space|secretory granule|cell differentiation|collagen-containing extracellular matrix|extracellular exosome ANK1 39.21213837 53.79266632 24.63161041 0.457899043 -1.126898546 0.219401682 1 0.291349458 0.139155341 286 ankyrin 1 "GO:0005198,GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0005886,GO:0006887,GO:0006888,GO:0007010,GO:0007165,GO:0008093,GO:0009898,GO:0010638,GO:0014731,GO:0016323,GO:0016529,GO:0019899,GO:0019903,GO:0030018,GO:0030507,GO:0030673,GO:0031430,GO:0042383,GO:0043005,GO:0044325,GO:0045199,GO:0045211,GO:0051117,GO:0072659" structural molecule activity|structural constituent of cytoskeleton|protein binding|nucleus|cytosol|cytoskeleton|plasma membrane|exocytosis|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|signal transduction|cytoskeletal anchor activity|cytoplasmic side of plasma membrane|positive regulation of organelle organization|spectrin-associated cytoskeleton|basolateral plasma membrane|sarcoplasmic reticulum|enzyme binding|protein phosphatase binding|Z disc|spectrin binding|axolemma|M band|sarcolemma|neuron projection|ion channel binding|maintenance of epithelial cell apical/basal polarity|postsynaptic membrane|ATPase binding|protein localization to plasma membrane hsa05205 Proteoglycans in cancer ANK2 463.0740297 370.4589285 555.6891309 1.500001993 0.584964417 0.160700039 1 1.093828358 1.711421345 287 ankyrin 2 "GO:0002027,GO:0003283,GO:0005515,GO:0005739,GO:0005764,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0006874,GO:0006888,GO:0006897,GO:0008093,GO:0010628,GO:0010881,GO:0010882,GO:0014704,GO:0015031,GO:0016323,GO:0016324,GO:0019899,GO:0019901,GO:0030018,GO:0030315,GO:0030507,GO:0030674,GO:0031430,GO:0031647,GO:0031672,GO:0033292,GO:0033365,GO:0034394,GO:0034613,GO:0036309,GO:0036371,GO:0042383,GO:0043005,GO:0043034,GO:0043268,GO:0044325,GO:0045211,GO:0050821,GO:0051117,GO:0051279,GO:0051924,GO:0051928,GO:0055037,GO:0055117,GO:0060307,GO:0070296,GO:0070972,GO:0072659,GO:0086004,GO:0086005,GO:0086014,GO:0086015,GO:0086046,GO:0086066,GO:0086070,GO:0086091,GO:0098907,GO:0098910,GO:0140031,GO:1901018,GO:1901019,GO:1901021,GO:2001259" regulation of heart rate|atrial septum development|protein binding|mitochondrion|lysosome|early endosome|cytosol|cytoskeleton|plasma membrane|cellular calcium ion homeostasis|endoplasmic reticulum to Golgi vesicle-mediated transport|endocytosis|cytoskeletal anchor activity|positive regulation of gene expression|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by calcium ion signaling|intercalated disc|protein transport|basolateral plasma membrane|apical plasma membrane|enzyme binding|protein kinase binding|Z disc|T-tubule|spectrin binding|protein-macromolecule adaptor activity|M band|regulation of protein stability|A band|T-tubule organization|protein localization to organelle|protein localization to cell surface|cellular protein localization|protein localization to M-band|protein localization to T-tubule|sarcolemma|neuron projection|costamere|positive regulation of potassium ion transport|ion channel binding|postsynaptic membrane|protein stabilization|ATPase binding|regulation of release of sequestered calcium ion into cytosol|regulation of calcium ion transport|positive regulation of calcium ion transport|recycling endosome|regulation of cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|sarcoplasmic reticulum calcium ion transport|protein localization to endoplasmic reticulum|protein localization to plasma membrane|regulation of cardiac muscle cell contraction|ventricular cardiac muscle cell action potential|atrial cardiac muscle cell action potential|SA node cell action potential|membrane depolarization during SA node cell action potential|atrial cardiac muscle cell to AV node cell communication|SA node cell to atrial cardiac muscle cell communication|regulation of heart rate by cardiac conduction|regulation of SA node cell action potential|regulation of atrial cardiac muscle cell action potential|phosphorylation-dependent protein binding|positive regulation of potassium ion transmembrane transporter activity|regulation of calcium ion transmembrane transporter activity|positive regulation of calcium ion transmembrane transporter activity|positive regulation of cation channel activity hsa05205 Proteoglycans in cancer ANK3 43.19773336 56.83753423 29.5579325 0.520042484 -0.943298608 0.289985838 1 0.153526432 0.083279462 288 ankyrin 3 "GO:0000281,GO:0005200,GO:0005515,GO:0005764,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005923,GO:0006888,GO:0007009,GO:0007010,GO:0007165,GO:0007409,GO:0007528,GO:0008092,GO:0008093,GO:0009925,GO:0009986,GO:0010628,GO:0010650,GO:0010765,GO:0010960,GO:0014704,GO:0014731,GO:0016323,GO:0016328,GO:0016529,GO:0019228,GO:0030018,GO:0030315,GO:0030425,GO:0030507,GO:0030674,GO:0031594,GO:0033268,GO:0034112,GO:0042383,GO:0043001,GO:0043005,GO:0043034,GO:0043194,GO:0043266,GO:0044325,GO:0045184,GO:0045211,GO:0045296,GO:0045838,GO:0071286,GO:0071709,GO:0072659,GO:0072660,GO:0090314,GO:0099612,GO:1900827,GO:1902260,GO:2000651,GO:2001259" mitotic cytokinesis|structural constituent of cytoskeleton|protein binding|lysosome|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|bicellular tight junction|endoplasmic reticulum to Golgi vesicle-mediated transport|plasma membrane organization|cytoskeleton organization|signal transduction|axonogenesis|neuromuscular junction development|cytoskeletal protein binding|cytoskeletal anchor activity|basal plasma membrane|cell surface|positive regulation of gene expression|positive regulation of cell communication by electrical coupling|positive regulation of sodium ion transport|magnesium ion homeostasis|intercalated disc|spectrin-associated cytoskeleton|basolateral plasma membrane|lateral plasma membrane|sarcoplasmic reticulum|neuronal action potential|Z disc|T-tubule|dendrite|spectrin binding|protein-macromolecule adaptor activity|neuromuscular junction|node of Ranvier|positive regulation of homotypic cell-cell adhesion|sarcolemma|Golgi to plasma membrane protein transport|neuron projection|costamere|axon initial segment|regulation of potassium ion transport|ion channel binding|establishment of protein localization|postsynaptic membrane|cadherin binding|positive regulation of membrane potential|cellular response to magnesium ion|membrane assembly|protein localization to plasma membrane|maintenance of protein location in plasma membrane|positive regulation of protein targeting to membrane|protein localization to axon|positive regulation of membrane depolarization during cardiac muscle cell action potential|negative regulation of delayed rectifier potassium channel activity|positive regulation of sodium ion transmembrane transporter activity|positive regulation of cation channel activity hsa05205 Proteoglycans in cancer ANKAR 30.98857019 30.44867905 31.52846133 1.035462369 0.050275123 0.996837457 1 0.254727152 0.275122107 150709 ankyrin and armadillo repeat containing GO:0016021 integral component of membrane ANKDD1A 114.4012737 108.6002886 120.2022588 1.106831854 0.14643607 0.832806129 1 1.773692841 2.047745557 348094 ankyrin repeat and death domain containing 1A GO:0007165 signal transduction ANKDD1B 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.056302234 0.019003163 728780 ankyrin repeat and death domain containing 1B GO:0007165 signal transduction ANKEF1 219.499197 254.7539481 184.2444459 0.723225086 -0.467483375 0.372482175 1 3.278045923 2.472887986 63926 ankyrin repeat and EF-hand domain containing 1 "GO:0005509,GO:0005515" calcium ion binding|protein binding ANKFY1 2222.448237 2875.370258 1569.526216 0.545851864 -0.873418616 0.006701914 0.333962311 18.23076614 10.37995922 51479 ankyrin repeat and FYVE domain containing 1 "GO:0005515,GO:0005765,GO:0005768,GO:0005769,GO:0005829,GO:0006897,GO:0010008,GO:0016020,GO:0016197,GO:0030904,GO:0031267,GO:0034058,GO:0042147,GO:0043231,GO:0044354,GO:0046872,GO:0048549,GO:0070062,GO:0090160,GO:1901981" "protein binding|lysosomal membrane|endosome|early endosome|cytosol|endocytosis|endosome membrane|membrane|endosomal transport|retromer complex|small GTPase binding|endosomal vesicle fusion|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|macropinosome|metal ion binding|positive regulation of pinocytosis|extracellular exosome|Golgi to lysosome transport|phosphatidylinositol phosphate binding" ANKH 515.8435752 576.49499 455.1921604 0.789585631 -0.340832359 0.401219102 1 3.499632925 2.8822899 56172 ANKH inorganic pyrophosphate transport regulator "GO:0001501,GO:0005315,GO:0005886,GO:0005887,GO:0007626,GO:0015114,GO:0016021,GO:0019867,GO:0030500,GO:0030504,GO:0030505,GO:0035435,GO:0055085" skeletal system development|inorganic phosphate transmembrane transporter activity|plasma membrane|integral component of plasma membrane|locomotory behavior|phosphate ion transmembrane transporter activity|integral component of membrane|outer membrane|regulation of bone mineralization|inorganic diphosphate transmembrane transporter activity|inorganic diphosphate transport|phosphate ion transmembrane transport|transmembrane transport ANKHD1 50.00550962 50.74779842 49.26322083 0.970745971 -0.042834281 0.986283638 1 0.304742348 0.308570451 54882 ankyrin repeat and KH domain containing 1 "GO:0003723,GO:0005515,GO:0005737,GO:0045087" RNA binding|protein binding|cytoplasm|innate immune response ANKIB1 2748.591806 2539.419833 2957.763778 1.164739969 0.220007906 0.489878456 1 20.28590789 24.64559786 54467 ankyrin repeat and IBR domain containing 1 "GO:0000151,GO:0000209,GO:0005515,GO:0005737,GO:0006511,GO:0031624,GO:0032436,GO:0046872,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|protein binding|cytoplasm|ubiquitin-dependent protein catabolic process|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity ANKLE1 13.50891049 14.20938356 12.80843742 0.901406973 -0.149749485 0.969790133 1 0.25242201 0.237336243 126549 ankyrin repeat and LEM domain containing 1 "GO:0004519,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006611,GO:0090305,GO:2001022" endonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|protein export from nucleus|nucleic acid phosphodiester bond hydrolysis|positive regulation of response to DNA damage stimulus ANKLE2 3075.541486 2831.727152 3319.355819 1.172201855 0.229221025 0.471320451 1 28.13201069 34.39688447 23141 ankyrin repeat and LEM domain containing 2 "GO:0005515,GO:0005783,GO:0005789,GO:0007084,GO:0007417,GO:0016020,GO:0019888,GO:0030176,GO:0035307,GO:0042326,GO:0043066,GO:0043666,GO:0050790,GO:0051301,GO:0051721" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|mitotic nuclear envelope reassembly|central nervous system development|membrane|protein phosphatase regulator activity|integral component of endoplasmic reticulum membrane|positive regulation of protein dephosphorylation|negative regulation of phosphorylation|negative regulation of apoptotic process|regulation of phosphoprotein phosphatase activity|regulation of catalytic activity|cell division|protein phosphatase 2A binding ANKMY1 130.2694248 115.7049804 144.8338692 1.251751383 0.323948049 0.607454215 1 0.644740794 0.841819844 51281 ankyrin repeat and MYND domain containing 1 GO:0046872 metal ion binding ANKMY2 505.2959012 495.2985126 515.2932899 1.040369145 0.057095517 0.893255039 1 9.363614167 10.16124454 57037 ankyrin repeat and MYND domain containing 2 "GO:0005515,GO:0005929,GO:0019899,GO:0046872" protein binding|cilium|enzyme binding|metal ion binding ANKRA2 254.7190594 204.0061496 305.4319691 1.497170402 0.582238433 0.243092356 1 4.801204363 7.497860478 57763 ankyrin repeat family A member 2 "GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0010468,GO:0016020,GO:0019901,GO:0031625,GO:0032991,GO:0042826,GO:0043254,GO:0050750,GO:1990393" protein binding|nucleus|cytosol|cytoskeleton|regulation of gene expression|membrane|protein kinase binding|ubiquitin protein ligase binding|protein-containing complex|histone deacetylase binding|regulation of protein-containing complex assembly|low-density lipoprotein particle receptor binding|3M complex ANKRD1 133.7772334 119.7648043 147.7896625 1.233999115 0.30334136 0.628012963 1 3.388639571 4.361703663 27063 ankyrin repeat domain 1 "GO:0000122,GO:0001085,GO:0001650,GO:0002039,GO:0003677,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0010976,GO:0019216,GO:0031432,GO:0031674,GO:0035690,GO:0035914,GO:0035994,GO:0042826,GO:0043065,GO:0043517,GO:0045214,GO:0045893,GO:0050714,GO:0055008,GO:0061629,GO:0070412,GO:0070528,GO:0071222,GO:0071260,GO:0071347,GO:0071356,GO:0071407,GO:0071456,GO:0071560,GO:2000279" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|fibrillar center|p53 binding|DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|positive regulation of neuron projection development|regulation of lipid metabolic process|titin binding|I band|cellular response to drug|skeletal muscle cell differentiation|response to muscle stretch|histone deacetylase binding|positive regulation of apoptotic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|sarcomere organization|positive regulation of transcription, DNA-templated|positive regulation of protein secretion|cardiac muscle tissue morphogenesis|RNA polymerase II-specific DNA-binding transcription factor binding|R-SMAD binding|protein kinase C signaling|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to organic cyclic compound|cellular response to hypoxia|cellular response to transforming growth factor beta stimulus|negative regulation of DNA biosynthetic process" ANKRD10 2166.593738 2054.27088 2278.916595 1.10935545 0.149721695 0.641176057 1 7.896893589 9.137827109 55608 ankyrin repeat domain 10 GO:0005515 protein binding ANKRD11 3334.331009 3280.33769 3388.324329 1.032919367 0.046727637 0.884033759 1 13.41874902 14.45753925 29123 ankyrin repeat domain 11 "GO:0005634,GO:0005654,GO:0005829,GO:0009653,GO:0042475,GO:0048705,GO:0060325" nucleus|nucleoplasm|cytosol|anatomical structure morphogenesis|odontogenesis of dentin-containing tooth|skeletal system morphogenesis|face morphogenesis ANKRD12 839.8671534 870.8322209 808.902086 0.928883965 -0.106429707 0.772262459 1 4.610556123 4.467151777 23253 ankyrin repeat domain 12 "GO:0005654,GO:0005829" nucleoplasm|cytosol ANKRD13A 1182.524402 1125.586169 1239.462636 1.101170812 0.139038275 0.68640276 1 13.8905869 15.95479458 88455 ankyrin repeat domain 13A "GO:0002091,GO:0005737,GO:0005770,GO:0005886,GO:0048471,GO:0140036,GO:1905667" negative regulation of receptor internalization|cytoplasm|late endosome|plasma membrane|perinuclear region of cytoplasm|ubiquitin-dependent protein binding|negative regulation of protein localization to endosome ANKRD13B 156.5988969 164.4228669 148.7749269 0.904831121 -0.144279545 0.813825935 1 1.870493746 1.765386168 124930 ankyrin repeat domain 13B "GO:0002091,GO:0005737,GO:0005769,GO:0005770,GO:0005886,GO:0043231,GO:0048471,GO:0140036" negative regulation of receptor internalization|cytoplasm|early endosome|late endosome|plasma membrane|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|ubiquitin-dependent protein binding ANKRD13C 640.459235 642.467128 638.4513419 0.99374943 -0.009045968 0.985828827 1 6.449691485 6.685467212 81573 ankyrin repeat domain 13C "GO:0005102,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0006621,GO:0010469,GO:0048471,GO:2000209" signaling receptor binding|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|protein retention in ER lumen|regulation of signaling receptor activity|perinuclear region of cytoplasm|regulation of anoikis ANKRD13D 761.2229117 714.5290017 807.9168216 1.130698432 0.1772142 0.634648646 1 14.85565404 17.52082276 338692 ankyrin repeat domain 13D "GO:0002091,GO:0005737,GO:0005770,GO:0005886,GO:0048471,GO:0140036" negative regulation of receptor internalization|cytoplasm|late endosome|plasma membrane|perinuclear region of cytoplasm|ubiquitin-dependent protein binding ANKRD16 127.0558102 165.4378228 88.67379749 0.535994708 -0.899709339 0.151521307 1 3.0557411 1.70841347 54522 ankyrin repeat domain 16 "GO:0005634,GO:0005737,GO:0006400" nucleus|cytoplasm|tRNA modification ANKRD17 2889.149599 2988.030371 2790.268828 0.933815417 -0.098790687 0.756913749 1 10.78409443 10.50414363 26057 ankyrin repeat domain 17 "GO:0000785,GO:0001955,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006275,GO:0016020,GO:0016032,GO:0031965,GO:0042742,GO:0043123,GO:0045087,GO:0045787,GO:0051151,GO:1900087,GO:1900245,GO:1900246" chromatin|blood vessel maturation|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of DNA replication|membrane|viral process|nuclear membrane|defense response to bacterium|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of cell cycle|negative regulation of smooth muscle cell differentiation|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway ANKRD18A 282.5209849 319.71113 245.3308397 0.767351577 -0.382040368 0.429336212 1 1.935481815 1.5491712 253650 ankyrin repeat domain 18A ANKRD18B 229.2951796 217.2005772 241.3897821 1.11136805 0.152336671 0.773972784 1 2.381563758 2.760807016 441459 ankyrin repeat domain 18B ANKRD20A1 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.065987085 0.066816 84210 ankyrin repeat domain 20 family member A1 GO:0005886 plasma membrane ANKRD23 39.66023325 50.74779842 28.57266808 0.563032663 -0.828709476 0.366324973 1 0.994658267 0.584148703 200539 ankyrin repeat domain 23 "GO:0005515,GO:0005654,GO:0005829,GO:0009612,GO:0014704,GO:0015629,GO:0030016,GO:0031432" protein binding|nucleoplasm|cytosol|response to mechanical stimulus|intercalated disc|actin cytoskeleton|myofibril|titin binding ANKRD24 7.523095107 9.134603715 5.911586499 0.64716398 -0.627796782 0.748279434 1 0.083978118 0.056688688 170961 ankyrin repeat domain 24 ANKRD26 579.6185383 558.2257826 601.0112941 1.076645531 0.106543343 0.790280682 1 0.865757184 0.972265276 22852 ankyrin repeat domain 26 "GO:0005515,GO:0005813,GO:0045599" protein binding|centrosome|negative regulation of fat cell differentiation ANKRD27 1032.834481 995.671805 1069.997156 1.074648444 0.10386478 0.768892289 1 11.3268788 12.69675085 84079 ankyrin repeat domain 27 "GO:0000149,GO:0005085,GO:0005096,GO:0005515,GO:0005764,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0010976,GO:0015031,GO:0016020,GO:0030133,GO:0030659,GO:0031267,GO:0035544,GO:0035646,GO:0042470,GO:0043005,GO:0043547,GO:0045022,GO:0048812,GO:0050775,GO:0097422,GO:1990126" "SNARE binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|lysosome|early endosome|late endosome|cytosol|plasma membrane|positive regulation of neuron projection development|protein transport|membrane|transport vesicle|cytoplasmic vesicle membrane|small GTPase binding|negative regulation of SNARE complex assembly|endosome to melanosome transport|melanosome|neuron projection|positive regulation of GTPase activity|early endosome to late endosome transport|neuron projection morphogenesis|positive regulation of dendrite morphogenesis|tubular endosome|retrograde transport, endosome to plasma membrane" ANKRD28 3031.926833 2577.98816 3485.865506 1.352165057 0.43527127 0.171589567 1 13.62759688 19.22051041 23243 ankyrin repeat domain 28 "GO:0000139,GO:0005515,GO:0005654,GO:0005829,GO:0048208" Golgi membrane|protein binding|nucleoplasm|cytosol|COPII vesicle coating ANKRD29 146.0457797 150.2134833 141.878076 0.944509593 -0.082362645 0.901605608 1 1.256446409 1.237845016 147463 ankyrin repeat domain 29 GO:0005515 protein binding ANKRD30B 15.97207153 14.20938356 17.7347595 1.248101962 0.319735798 0.833790251 1 0.155735804 0.202747013 374860 ankyrin repeat domain 30B "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process ANKRD31 8.015727316 9.134603715 6.896850916 0.755024644 -0.405404361 0.864587159 1 0.071185637 0.056062109 256006 ankyrin repeat domain 31 "GO:0000785,GO:0005634,GO:0007129,GO:0010780,GO:1903343" chromatin|nucleus|homologous chromosome pairing at meiosis|meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|positive regulation of meiotic DNA double-strand break formation ANKRD33B 622.9093057 756.1421964 489.676415 0.647598319 -0.626828855 0.106190215 1 3.95946389 2.674595002 651746 ankyrin repeat domain 33B ANKRD34A 112.5049738 113.6750685 111.3348791 0.979413345 -0.030010241 0.978467999 1 1.596130079 1.630610479 284615 ankyrin repeat domain 34A ANKRD36 140.6443927 117.7348923 163.5538931 1.389170958 0.474224155 0.435785275 1 0.638421515 0.925079676 375248 ankyrin repeat domain 36 ANKRD36B 87.4725274 86.27125731 88.67379749 1.027848675 0.039627879 0.97324538 1 0.500668596 0.536778931 57730 ankyrin repeat domain 36B GO:0005515 protein binding ANKRD36C 147.7369603 97.43577296 198.0381477 2.032499376 1.023254909 0.087080849 1 0.602389913 1.277097462 400986 ankyrin repeat domain 36C GO:0008200 ion channel inhibitor activity ANKRD37 82.03600573 118.7498483 45.32216316 0.381660809 -1.389637045 0.057329497 1 7.671251138 3.05393435 353322 ankyrin repeat domain 37 "GO:0005515,GO:0005654,GO:0005739,GO:0005829" protein binding|nucleoplasm|mitochondrion|cytosol ANKRD39 120.4019349 114.6900244 126.1138453 1.099606055 0.136986756 0.841149447 1 6.511934008 7.469010039 51239 ankyrin repeat domain 39 "GO:0003674,GO:0004842,GO:0005575,GO:0008150,GO:0031436,GO:0070531,GO:0085020" molecular_function|ubiquitin-protein transferase activity|cellular_component|biological_process|BRCA1-BARD1 complex|BRCA1-A complex|protein K6-linked ubiquitination ANKRD40 2190.578815 2111.108414 2270.049216 1.075287844 0.104722907 0.744731307 1 24.83628191 27.85654476 91369 ankyrin repeat domain 40 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process ANKRD42 471.8293242 463.8348775 479.8237709 1.034471089 0.048893326 0.911235686 1 3.842892236 4.146603341 338699 ankyrin repeat domain 42 ANKRD44 138.7926301 125.8545401 151.7307201 1.205603867 0.269755949 0.663755535 1 0.598899602 0.753138045 91526 ankyrin repeat domain 44 GO:0005515 protein binding ANKRD46 112.0717247 117.7348923 106.408557 0.903797973 -0.145927774 0.834772358 1 1.381890371 1.302749404 157567 ankyrin repeat domain 46 GO:0016021 integral component of membrane ANKRD49 202.5918416 176.6023385 228.5813446 1.294327961 0.372203218 0.490609157 1 4.46767504 6.031729261 54851 ankyrin repeat domain 49 "GO:0005515,GO:0005634,GO:0007283,GO:0030154,GO:0045893" "protein binding|nucleus|spermatogenesis|cell differentiation|positive regulation of transcription, DNA-templated" ANKRD50 1012.440843 1015.970924 1008.910763 0.993050823 -0.01006054 0.980307111 1 5.247332571 5.435330985 57182 ankyrin repeat domain 50 "GO:0005515,GO:0005768,GO:0015031,GO:1990126" "protein binding|endosome|protein transport|retrograde transport, endosome to plasma membrane" ANKRD52 5019.82374 3967.46288 6072.184599 1.53049563 0.613998925 0.056577098 1 22.51658433 35.94599702 283373 ankyrin repeat domain 52 GO:0005515 protein binding ANKRD53 13.94215959 10.14955968 17.7347595 1.747342747 0.805162625 0.540804743 1 0.242471412 0.441931107 79998 ankyrin repeat domain 53 "GO:0000922,GO:0005515,GO:0005737,GO:0005819,GO:0007080,GO:0031116,GO:0051301,GO:0060236,GO:1902412" spindle pole|protein binding|cytoplasm|spindle|mitotic metaphase plate congression|positive regulation of microtubule polymerization|cell division|regulation of mitotic spindle organization|regulation of mitotic cytokinesis ANKRD54 571.0750441 614.0483609 528.1017273 0.860032794 -0.217536423 0.584071074 1 8.913552091 7.996165018 129138 ankyrin repeat domain 54 "GO:0005515,GO:0005634,GO:0005737,GO:0006913,GO:0019887,GO:0030496,GO:0044877,GO:0045648,GO:0045859,GO:1902531" protein binding|nucleus|cytoplasm|nucleocytoplasmic transport|protein kinase regulator activity|midbody|protein-containing complex binding|positive regulation of erythrocyte differentiation|regulation of protein kinase activity|regulation of intracellular signal transduction ANKRD6 446.188201 394.8178717 497.5585304 1.260222918 0.333678951 0.428810925 1 2.50483933 3.292631864 22881 ankyrin repeat domain 6 "GO:0005634,GO:0005737,GO:0043231,GO:0046330,GO:0090090,GO:2000096" "nucleus|cytoplasm|intracellular membrane-bounded organelle|positive regulation of JNK cascade|negative regulation of canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway" ANKRD61 7.015617123 8.119647747 5.911586499 0.728059478 -0.457871781 0.855058357 1 0.288989117 0.219464499 100310846 ankyrin repeat domain 61 GO:0005654 nucleoplasm ANKRD63 7.508249331 8.119647747 6.896850916 0.849402724 -0.235479359 0.974243744 1 0.087626574 0.077636404 100131244 ankyrin repeat domain 63 ANKRD9 931.2592117 854.5929254 1007.925498 1.179421767 0.238079725 0.505457375 1 5.859227947 7.208177335 122416 ankyrin repeat domain 9 "GO:0005829,GO:0043687" cytosol|post-translational protein modification ANKS1A 512.9971456 516.6125879 509.3817034 0.986003275 -0.020335657 0.965289406 1 2.205192168 2.267987875 23294 ankyrin repeat and sterile alpha motif domain containing 1A "GO:0005515,GO:0005654,GO:0005829,GO:0006929,GO:0016322,GO:0043005,GO:0046875,GO:0048013,GO:1901187" protein binding|nucleoplasm|cytosol|substrate-dependent cell migration|neuron remodeling|neuron projection|ephrin receptor binding|ephrin receptor signaling pathway|regulation of ephrin receptor signaling pathway ANKS3 194.6476215 206.0360616 183.2591815 0.889451973 -0.169011387 0.762795152 1 3.618238442 3.35687845 124401 ankyrin repeat and sterile alpha motif domain containing 3 "GO:0005515,GO:0005737,GO:0005929" protein binding|cytoplasm|cilium ANKS6 464.4965026 501.3882484 427.6047568 0.852841602 -0.22965028 0.583327471 1 5.053441988 4.495433642 203286 ankyrin repeat and sterile alpha motif domain containing 6 "GO:0001701,GO:0001822,GO:0005515,GO:0005737,GO:0007368,GO:0007507,GO:0097543" in utero embryonic development|kidney development|protein binding|cytoplasm|determination of left/right symmetry|heart development|ciliary inversin compartment ANKZF1 709.7528673 866.772397 552.7333377 0.63769144 -0.64906958 0.085199402 1 17.86689626 11.88435545 55139 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 "GO:0005515,GO:0005737,GO:0016020,GO:0030433,GO:0046872,GO:0070301" protein binding|cytoplasm|membrane|ubiquitin-dependent ERAD pathway|metal ion binding|cellular response to hydrogen peroxide ANLN 4521.27574 4202.932665 4839.618814 1.151486164 0.203497077 0.524696889 1 43.99828698 52.84579333 54443 anillin actin binding protein "GO:0000281,GO:0000915,GO:0000921,GO:0003779,GO:0005654,GO:0005826,GO:0007096,GO:0015629,GO:0030496,GO:0031106,GO:0032059,GO:0045296,GO:0090521,GO:0099738,GO:1904172" mitotic cytokinesis|actomyosin contractile ring assembly|septin ring assembly|actin binding|nucleoplasm|actomyosin contractile ring|regulation of exit from mitosis|actin cytoskeleton|midbody|septin ring organization|bleb|cadherin binding|glomerular visceral epithelial cell migration|cell cortex region|positive regulation of bleb assembly ANO10 746.7502635 802.830171 690.670356 0.860294469 -0.217097532 0.561330766 1 8.217565874 7.374053003 55129 anoctamin 10 "GO:0005227,GO:0005229,GO:0005886,GO:0006812,GO:0006821,GO:0016020,GO:0016021,GO:0034220,GO:0043231,GO:0055085,GO:0098655,GO:1902476" calcium activated cation channel activity|intracellular calcium activated chloride channel activity|plasma membrane|cation transport|chloride transport|membrane|integral component of membrane|ion transmembrane transport|intracellular membrane-bounded organelle|transmembrane transport|cation transmembrane transport|chloride transmembrane transport ANO6 3548.270959 3424.461437 3672.08048 1.072308901 0.100720564 0.752086527 1 24.04837646 26.89809992 196527 anoctamin 6 "GO:0002407,GO:0002543,GO:0005227,GO:0005229,GO:0005244,GO:0005247,GO:0005254,GO:0005515,GO:0005829,GO:0005886,GO:0006812,GO:0006821,GO:0007596,GO:0009986,GO:0016020,GO:0017121,GO:0017128,GO:0030501,GO:0032060,GO:0034220,GO:0034707,GO:0034767,GO:0035579,GO:0035590,GO:0035725,GO:0043065,GO:0043312,GO:0045794,GO:0046872,GO:0046931,GO:0046983,GO:0055085,GO:0060100,GO:0061589,GO:0061590,GO:0070062,GO:0070588,GO:0070821,GO:0090026,GO:0097045,GO:1902476,GO:1903766,GO:2000353" "dendritic cell chemotaxis|activation of blood coagulation via clotting cascade|calcium activated cation channel activity|intracellular calcium activated chloride channel activity|voltage-gated ion channel activity|voltage-gated chloride channel activity|chloride channel activity|protein binding|cytosol|plasma membrane|cation transport|chloride transport|blood coagulation|cell surface|membrane|plasma membrane phospholipid scrambling|phospholipid scramblase activity|positive regulation of bone mineralization|bleb assembly|ion transmembrane transport|chloride channel complex|positive regulation of ion transmembrane transport|specific granule membrane|purinergic nucleotide receptor signaling pathway|sodium ion transmembrane transport|positive regulation of apoptotic process|neutrophil degranulation|negative regulation of cell volume|metal ion binding|pore complex assembly|protein dimerization activity|transmembrane transport|positive regulation of phagocytosis, engulfment|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|extracellular exosome|calcium ion transmembrane transport|tertiary granule membrane|positive regulation of monocyte chemotaxis|phosphatidylserine exposure on blood platelet|chloride transmembrane transport|positive regulation of potassium ion export across plasma membrane|positive regulation of endothelial cell apoptotic process" ANO7 79.91701914 108.6002886 51.23374966 0.471764397 -1.08386155 0.139108325 1 1.057125024 0.520196524 50636 anoctamin 7 "GO:0005229,GO:0005254,GO:0005783,GO:0005829,GO:0005886,GO:0006821,GO:0016021,GO:0017128,GO:0030054,GO:0034220,GO:0046983,GO:0055085,GO:0061588,GO:0061589,GO:0061590,GO:0061591,GO:1902476" intracellular calcium activated chloride channel activity|chloride channel activity|endoplasmic reticulum|cytosol|plasma membrane|chloride transport|integral component of membrane|phospholipid scramblase activity|cell junction|ion transmembrane transport|protein dimerization activity|transmembrane transport|calcium activated phospholipid scrambling|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling|chloride transmembrane transport ANO8 408.4309487 440.4908903 376.3710071 0.854435393 -0.226956686 0.601038023 1 4.471699666 3.985362104 57719 anoctamin 8 "GO:0005229,GO:0005788,GO:0005886,GO:0006821,GO:0016021,GO:0034220,GO:0043687,GO:0044267,GO:0055085,GO:1902476" intracellular calcium activated chloride channel activity|endoplasmic reticulum lumen|plasma membrane|chloride transport|integral component of membrane|ion transmembrane transport|post-translational protein modification|cellular protein metabolic process|transmembrane transport|chloride transmembrane transport ANO9 112.7479494 62.92727004 162.5686287 2.583436857 1.369291623 0.037683606 0.880626892 0.652547959 1.758434585 338440 anoctamin 9 "GO:0005229,GO:0005254,GO:0005515,GO:0005886,GO:0006821,GO:0016021,GO:0017128,GO:0034220,GO:0055085,GO:0061589,GO:0061590,GO:0061591,GO:1902476,GO:1902939" intracellular calcium activated chloride channel activity|chloride channel activity|protein binding|plasma membrane|chloride transport|integral component of membrane|phospholipid scramblase activity|ion transmembrane transport|transmembrane transport|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling|chloride transmembrane transport|negative regulation of intracellular calcium activated chloride channel activity ANOS1 47.94590613 44.65806261 51.23374966 1.147245238 0.198173818 0.838526397 1 0.339249037 0.405967079 3730 anosmin 1 "GO:0004867,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0006935,GO:0007155,GO:0007411,GO:0008201,GO:0008543,GO:0009986,GO:0010951,GO:0030182,GO:0031012" serine-type endopeptidase inhibitor activity|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|plasma membrane|chemotaxis|cell adhesion|axon guidance|heparin binding|fibroblast growth factor receptor signaling pathway|cell surface|negative regulation of endopeptidase activity|neuron differentiation|extracellular matrix ANP32A 2253.731247 2589.152675 1918.309819 0.74090255 -0.432644296 0.176740546 1 53.74239714 41.53307182 8125 acidic nuclear phosphoprotein 32 family member A "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0006913,GO:0035556,GO:0042393,GO:0042981,GO:0043488,GO:0048471" RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|nucleocytoplasmic transport|intracellular signal transduction|histone binding|regulation of apoptotic process|regulation of mRNA stability|perinuclear region of cytoplasm ANP32B 3797.063586 3627.452631 3966.674541 1.093515187 0.128973257 0.685809989 1 123.8824537 141.3027283 10541 acidic nuclear phosphoprotein 32 family member B "GO:0001944,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006334,GO:0006919,GO:0021591,GO:0042393,GO:0042981,GO:0045596,GO:0046827,GO:0048839,GO:0060021,GO:0070062,GO:0070063" vasculature development|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|nucleosome assembly|activation of cysteine-type endopeptidase activity involved in apoptotic process|ventricular system development|histone binding|regulation of apoptotic process|negative regulation of cell differentiation|positive regulation of protein export from nucleus|inner ear development|roof of mouth development|extracellular exosome|RNA polymerase binding ANP32C 9.075220612 14.20938356 3.941057666 0.277355992 -1.850189203 0.218517863 1 0.732846384 0.212014923 23520 acidic nuclear phosphoprotein 32 family member C "GO:0005634,GO:0006913,GO:0042393,GO:0042981,GO:0048471" nucleus|nucleocytoplasmic transport|histone binding|regulation of apoptotic process|perinuclear region of cytoplasm ANP32E 1500.108381 1855.33951 1144.877252 0.617071563 -0.696490283 0.036158419 0.858303341 26.23294275 16.88489928 81611 acidic nuclear phosphoprotein 32 family member E "GO:0000812,GO:0005515,GO:0005634,GO:0019212,GO:0031410,GO:0042393,GO:0042981,GO:0043086,GO:0043486" Swr1 complex|protein binding|nucleus|phosphatase inhibitor activity|cytoplasmic vesicle|histone binding|regulation of apoptotic process|negative regulation of catalytic activity|histone exchange ANTKMT 146.3426952 170.5126027 122.1727877 0.716502978 -0.480955394 0.422799582 1 9.926277924 7.418572758 65990 adenine nucleotide translocase lysine methyltransferase "GO:0005515,GO:0005739,GO:0016021,GO:0016279,GO:0018023,GO:0031966,GO:1905273,GO:1905706" "protein binding|mitochondrion|integral component of membrane|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|mitochondrial membrane|positive regulation of proton-transporting ATP synthase activity, rotational mechanism|regulation of mitochondrial ATP synthesis coupled proton transport" ANTXR1 3953.192861 3692.409813 4213.97591 1.141253578 0.190619383 0.549871657 1 15.74800261 18.74664519 84168 ANTXR cell adhesion molecule 1 "GO:0001568,GO:0004888,GO:0005515,GO:0005518,GO:0005886,GO:0009897,GO:0009986,GO:0010008,GO:0016021,GO:0022414,GO:0031258,GO:0031527,GO:0031532,GO:0034446,GO:0046872,GO:0051015,GO:1901202,GO:1901998,GO:1905050" blood vessel development|transmembrane signaling receptor activity|protein binding|collagen binding|plasma membrane|external side of plasma membrane|cell surface|endosome membrane|integral component of membrane|reproductive process|lamellipodium membrane|filopodium membrane|actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading|metal ion binding|actin filament binding|negative regulation of extracellular matrix assembly|toxin transport|positive regulation of metallopeptidase activity hsa04621 NOD-like receptor signaling pathway ANTXR2 917.3724759 713.5140458 1121.230906 1.571420931 0.652069682 0.068918274 1 3.640270907 5.966809439 118429 ANTXR cell adhesion molecule 2 "GO:0004888,GO:0005515,GO:0005576,GO:0005789,GO:0005886,GO:0009986,GO:0010008,GO:0016021,GO:0046872,GO:1901998" transmembrane signaling receptor activity|protein binding|extracellular region|endoplasmic reticulum membrane|plasma membrane|cell surface|endosome membrane|integral component of membrane|metal ion binding|toxin transport hsa04621 NOD-like receptor signaling pathway ANXA1 3724.743399 4273.979583 3175.507215 0.742986052 -0.428592968 0.178551994 1 130.2418701 100.9362612 301 annexin A1 "GO:0001533,GO:0001780,GO:0001891,GO:0002250,GO:0002548,GO:0002685,GO:0003697,GO:0003727,GO:0005102,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0005884,GO:0005886,GO:0005912,GO:0005925,GO:0006909,GO:0006954,GO:0007165,GO:0007166,GO:0007186,GO:0007187,GO:0008360,GO:0009986,GO:0010165,GO:0014839,GO:0016323,GO:0016324,GO:0016328,GO:0018149,GO:0019221,GO:0019834,GO:0019898,GO:0030073,GO:0030216,GO:0030659,GO:0030850,GO:0031018,GO:0031232,GO:0031313,GO:0031340,GO:0031394,GO:0031514,GO:0031532,GO:0031901,GO:0031966,GO:0031982,GO:0032355,GO:0032508,GO:0032652,GO:0032717,GO:0032743,GO:0032991,GO:0033031,GO:0035924,GO:0036121,GO:0042063,GO:0042102,GO:0042383,GO:0042493,GO:0042629,GO:0042802,GO:0043066,GO:0043434,GO:0044849,GO:0045087,GO:0045627,GO:0045629,GO:0045920,GO:0046632,GO:0046883,GO:0048306,GO:0050482,GO:0050709,GO:0050727,GO:0062023,GO:0070062,GO:0070301,GO:0070365,GO:0070459,GO:0070555,GO:0071385,GO:0071621,GO:0090050,GO:0090303,GO:0097060,GO:0097350,GO:0098609,GO:0098641,GO:1900087,GO:1900138,GO:1990814" "cornified envelope|neutrophil homeostasis|phagocytic cup|adaptive immune response|monocyte chemotaxis|regulation of leukocyte migration|single-stranded DNA binding|single-stranded RNA binding|signaling receptor binding|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|extracellular region|extracellular space|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|actin filament|plasma membrane|adherens junction|focal adhesion|phagocytosis|inflammatory response|signal transduction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|regulation of cell shape|cell surface|response to X-ray|myoblast migration involved in skeletal muscle regeneration|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|peptide cross-linking|cytokine-mediated signaling pathway|phospholipase A2 inhibitor activity|extrinsic component of membrane|insulin secretion|keratinocyte differentiation|cytoplasmic vesicle membrane|prostate gland development|endocrine pancreas development|extrinsic component of external side of plasma membrane|extrinsic component of endosome membrane|positive regulation of vesicle fusion|positive regulation of prostaglandin biosynthetic process|motile cilium|actin cytoskeleton reorganization|early endosome membrane|mitochondrial membrane|vesicle|response to estradiol|DNA duplex unwinding|regulation of interleukin-1 production|negative regulation of interleukin-8 production|positive regulation of interleukin-2 production|protein-containing complex|positive regulation of neutrophil apoptotic process|cellular response to vascular endothelial growth factor stimulus|double-stranded DNA helicase activity|gliogenesis|positive regulation of T cell proliferation|sarcolemma|response to drug|mast cell granule|identical protein binding|negative regulation of apoptotic process|response to peptide hormone|estrous cycle|innate immune response|positive regulation of T-helper 1 cell differentiation|negative regulation of T-helper 2 cell differentiation|negative regulation of exocytosis|alpha-beta T cell differentiation|regulation of hormone secretion|calcium-dependent protein binding|arachidonic acid secretion|negative regulation of protein secretion|regulation of inflammatory response|collagen-containing extracellular matrix|extracellular exosome|cellular response to hydrogen peroxide|hepatocyte differentiation|prolactin secretion|response to interleukin-1|cellular response to glucocorticoid stimulus|granulocyte chemotaxis|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of wound healing|synaptic membrane|neutrophil clearance|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of G1/S transition of mitotic cell cycle|negative regulation of phospholipase A2 activity|DNA/DNA annealing activity" ANXA11 4013.4182 3633.542367 4393.294033 1.209093934 0.273926331 0.39024798 1 21.22316947 26.76616889 311 annexin A11 "GO:0003723,GO:0005509,GO:0005515,GO:0005544,GO:0005635,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0006909,GO:0016020,GO:0023026,GO:0030496,GO:0032506,GO:0042470,GO:0042581,GO:0042582,GO:0044548,GO:0045335,GO:0048306,GO:0051592,GO:0062023,GO:0070062" RNA binding|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nuclear envelope|nucleoplasm|cytoplasm|spindle|cytosol|phagocytosis|membrane|MHC class II protein complex binding|midbody|cytokinetic process|melanosome|specific granule|azurophil granule|S100 protein binding|phagocytic vesicle|calcium-dependent protein binding|response to calcium ion|collagen-containing extracellular matrix|extracellular exosome hsa05014 Amyotrophic lateral sclerosis ANXA2 22280.54048 21741.3718 22819.70915 1.049598405 0.069837432 0.850206718 1 210.6607581 230.633683 302 annexin A2 "GO:0001525,GO:0001765,GO:0001786,GO:0001921,GO:0002020,GO:0003723,GO:0004867,GO:0005262,GO:0005509,GO:0005515,GO:0005544,GO:0005546,GO:0005576,GO:0005604,GO:0005615,GO:0005634,GO:0005737,GO:0005765,GO:0005768,GO:0005811,GO:0005886,GO:0005912,GO:0006900,GO:0008092,GO:0009986,GO:0010951,GO:0016020,GO:0016032,GO:0016323,GO:0019834,GO:0030496,GO:0031340,GO:0031902,GO:0031982,GO:0032804,GO:0035578,GO:0035722,GO:0036035,GO:0042470,GO:0042802,GO:0043312,GO:0044090,GO:0044147,GO:0044548,GO:0045121,GO:0046790,GO:0048306,GO:0052362,GO:0052405,GO:0062023,GO:0070062,GO:0070588,GO:0098609,GO:0098641,GO:1905581,GO:1905597,GO:1905599,GO:1905602,GO:1990665,GO:1990667" "angiogenesis|membrane raft assembly|phosphatidylserine binding|positive regulation of receptor recycling|protease binding|RNA binding|serine-type endopeptidase inhibitor activity|calcium channel activity|calcium ion binding|protein binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|basement membrane|extracellular space|nucleus|cytoplasm|lysosomal membrane|endosome|lipid droplet|plasma membrane|adherens junction|vesicle budding from membrane|cytoskeletal protein binding|cell surface|negative regulation of endopeptidase activity|membrane|viral process|basolateral plasma membrane|phospholipase A2 inhibitor activity|midbody|positive regulation of vesicle fusion|late endosome membrane|vesicle|negative regulation of low-density lipoprotein particle receptor catabolic process|azurophil granule lumen|interleukin-12-mediated signaling pathway|osteoclast development|melanosome|identical protein binding|neutrophil degranulation|positive regulation of vacuole organization|negative regulation of development of symbiont involved in interaction with host|S100 protein binding|membrane raft|virion binding|calcium-dependent protein binding|catabolism by host of symbiont protein|negative regulation by host of symbiont molecular function|collagen-containing extracellular matrix|extracellular exosome|calcium ion transmembrane transport|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of low-density lipoprotein particle clearance|positive regulation of low-density lipoprotein particle receptor binding|positive regulation of low-density lipoprotein receptor activity|positive regulation of receptor-mediated endocytosis involved in cholesterol transport|AnxA2-p11 complex|PCSK9-AnxA2 complex" hsa05132 Salmonella infection ANXA2R 38.1377993 47.70293051 28.57266808 0.598970918 -0.739442138 0.427469243 1 2.117427822 1.322909945 389289 annexin A2 receptor "GO:0005515,GO:0038023" protein binding|signaling receptor activity ANXA3 1179.601022 1094.122534 1265.079511 1.156250303 0.209453743 0.542116053 1 38.69654086 46.67022919 306 annexin A3 "GO:0005509,GO:0005544,GO:0005737,GO:0005886,GO:0006909,GO:0010595,GO:0016020,GO:0019834,GO:0021766,GO:0030424,GO:0030425,GO:0030670,GO:0031100,GO:0042581,GO:0042742,GO:0043025,GO:0043086,GO:0043312,GO:0045766,GO:0048306,GO:0051054,GO:0051091,GO:0051384,GO:0070062,GO:0070848" calcium ion binding|calcium-dependent phospholipid binding|cytoplasm|plasma membrane|phagocytosis|positive regulation of endothelial cell migration|membrane|phospholipase A2 inhibitor activity|hippocampus development|axon|dendrite|phagocytic vesicle membrane|animal organ regeneration|specific granule|defense response to bacterium|neuronal cell body|negative regulation of catalytic activity|neutrophil degranulation|positive regulation of angiogenesis|calcium-dependent protein binding|positive regulation of DNA metabolic process|positive regulation of DNA-binding transcription factor activity|response to glucocorticoid|extracellular exosome|response to growth factor ANXA4 532.0316524 504.4331163 559.6301886 1.109423966 0.149810797 0.71257223 1 3.579621382 4.142386015 307 annexin A4 "GO:0004859,GO:0005509,GO:0005515,GO:0005544,GO:0005634,GO:0005737,GO:0005886,GO:0006357,GO:0007165,GO:0007219,GO:0009986,GO:0012506,GO:0030855,GO:0031965,GO:0032088,GO:0032717,GO:0042802,GO:0043066,GO:0043086,GO:0048306,GO:0048471,GO:0051059,GO:0062023,GO:0070062" phospholipase inhibitor activity|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|plasma membrane|regulation of transcription by RNA polymerase II|signal transduction|Notch signaling pathway|cell surface|vesicle membrane|epithelial cell differentiation|nuclear membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-8 production|identical protein binding|negative regulation of apoptotic process|negative regulation of catalytic activity|calcium-dependent protein binding|perinuclear region of cytoplasm|NF-kappaB binding|collagen-containing extracellular matrix|extracellular exosome ANXA5 6463.276449 6226.754866 6699.798033 1.075969454 0.105637121 0.746015769 1 120.6900755 135.4526266 308 annexin A5 "GO:0002576,GO:0004859,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005576,GO:0005737,GO:0005829,GO:0005925,GO:0007165,GO:0007596,GO:0016020,GO:0043066,GO:0043086,GO:0050819,GO:0062023,GO:0070062" platelet degranulation|phospholipase inhibitor activity|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|extracellular region|cytoplasm|cytosol|focal adhesion|signal transduction|blood coagulation|membrane|negative regulation of apoptotic process|negative regulation of catalytic activity|negative regulation of coagulation|collagen-containing extracellular matrix|extracellular exosome ANXA6 10137.03427 10753.45848 9520.610057 0.885353309 -0.175674802 0.602060354 1 179.0939613 165.3916147 309 annexin A6 "GO:0001755,GO:0001778,GO:0001786,GO:0003418,GO:0005262,GO:0005509,GO:0005515,GO:0005525,GO:0005544,GO:0005737,GO:0005739,GO:0005765,GO:0005925,GO:0006937,GO:0008289,GO:0015276,GO:0015485,GO:0016020,GO:0031902,GO:0034220,GO:0035374,GO:0042470,GO:0042802,GO:0048306,GO:0048471,GO:0051015,GO:0051283,GO:0051560,GO:0062023,GO:0070062,GO:0070588,GO:0097190" neural crest cell migration|plasma membrane repair|phosphatidylserine binding|growth plate cartilage chondrocyte differentiation|calcium channel activity|calcium ion binding|protein binding|GTP binding|calcium-dependent phospholipid binding|cytoplasm|mitochondrion|lysosomal membrane|focal adhesion|regulation of muscle contraction|lipid binding|ligand-gated ion channel activity|cholesterol binding|membrane|late endosome membrane|ion transmembrane transport|chondroitin sulfate binding|melanosome|identical protein binding|calcium-dependent protein binding|perinuclear region of cytoplasm|actin filament binding|negative regulation of sequestering of calcium ion|mitochondrial calcium ion homeostasis|collagen-containing extracellular matrix|extracellular exosome|calcium ion transmembrane transport|apoptotic signaling pathway ANXA7 3998.865634 4154.214779 3843.516489 0.925208901 -0.11214895 0.725329918 1 82.02585705 79.16013182 310 annexin A7 "GO:0003723,GO:0005178,GO:0005509,GO:0005515,GO:0005544,GO:0005634,GO:0005737,GO:0005789,GO:0006914,GO:0010629,GO:0014070,GO:0016020,GO:0030855,GO:0042584,GO:0048306,GO:0051592,GO:0061025,GO:0062023,GO:0070062" RNA binding|integrin binding|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|endoplasmic reticulum membrane|autophagy|negative regulation of gene expression|response to organic cyclic compound|membrane|epithelial cell differentiation|chromaffin granule membrane|calcium-dependent protein binding|response to calcium ion|membrane fusion|collagen-containing extracellular matrix|extracellular exosome hsa05014 Amyotrophic lateral sclerosis ANXA8 155.0616172 160.363043 149.7601913 0.933882199 -0.098687516 0.876520352 1 2.165241909 2.10918392 653145 annexin A8 "GO:0005509,GO:0005515,GO:0005544,GO:0005546,GO:0005547,GO:0005737,GO:0005829,GO:0005886,GO:0007032,GO:0007596,GO:0016197,GO:0031902,GO:0043325,GO:0051015,GO:0062023,GO:1900004,GO:1900138" "calcium ion binding|protein binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|plasma membrane|endosome organization|blood coagulation|endosomal transport|late endosome membrane|phosphatidylinositol-3,4-bisphosphate binding|actin filament binding|collagen-containing extracellular matrix|negative regulation of serine-type endopeptidase activity|negative regulation of phospholipase A2 activity" ANXA8L1 111.5521225 82.21143344 140.8928116 1.713786096 0.777187053 0.23551714 1 2.059208249 3.681059303 728113 annexin A8 like 1 "GO:0005509,GO:0005544,GO:0005737,GO:0007032,GO:0016197,GO:1900004,GO:1900138" calcium ion binding|calcium-dependent phospholipid binding|cytoplasm|endosome organization|endosomal transport|negative regulation of serine-type endopeptidase activity|negative regulation of phospholipase A2 activity AOC2 25.00275481 25.37389921 24.63161041 0.970745971 -0.042834281 1 1 0.495030232 0.501248687 314 amine oxidase copper containing 2 "GO:0005507,GO:0005515,GO:0005737,GO:0005886,GO:0006584,GO:0006805,GO:0007601,GO:0008131,GO:0009055,GO:0009308,GO:0022900,GO:0048038,GO:0052593,GO:0052594,GO:0052595,GO:0052596" copper ion binding|protein binding|cytoplasm|plasma membrane|catecholamine metabolic process|xenobiotic metabolic process|visual perception|primary amine oxidase activity|electron transfer activity|amine metabolic process|electron transport chain|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|aliphatic-amine oxidase activity|phenethylamine:oxygen oxidoreductase (deaminating) activity "hsa00260,hsa00350,hsa00360,hsa00410" "Glycine, serine and threonine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism" AOC3 6.971079795 5.074779842 8.867379749 1.747342747 0.805162625 0.671092798 1 0.050714226 0.092432315 8639 amine oxidase copper containing 3 "GO:0005507,GO:0005509,GO:0005515,GO:0005737,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005902,GO:0006805,GO:0006954,GO:0007155,GO:0008131,GO:0009308,GO:0009986,GO:0016021,GO:0042802,GO:0046677,GO:0046982,GO:0048038,GO:0052593,GO:0052594,GO:0052595,GO:0052596,GO:0055114,GO:1902283" copper ion binding|calcium ion binding|protein binding|cytoplasm|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|microvillus|xenobiotic metabolic process|inflammatory response|cell adhesion|primary amine oxidase activity|amine metabolic process|cell surface|integral component of membrane|identical protein binding|response to antibiotic|protein heterodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|aliphatic-amine oxidase activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|oxidation-reduction process|negative regulation of primary amine oxidase activity "hsa00260,hsa00350,hsa00360,hsa00410" "Glycine, serine and threonine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism" AOPEP 177.0937329 184.7219862 169.4654796 0.91740828 -0.124364167 0.833113345 1 0.562974903 0.538725608 84909 aminopeptidase O (putative) "GO:0002003,GO:0005730,GO:0005829,GO:0008270,GO:0070006" angiotensin maturation|nucleolus|cytosol|zinc ion binding|metalloaminopeptidase activity AOX1 240.4272821 270.9932436 209.8613207 0.774415325 -0.368820593 0.469511766 1 2.695375448 2.177254197 316 aldehyde oxidase 1 "GO:0004031,GO:0004854,GO:0005506,GO:0005829,GO:0009055,GO:0009115,GO:0017144,GO:0022900,GO:0042802,GO:0042803,GO:0042816,GO:0043546,GO:0050660,GO:0051287,GO:0051537,GO:0055114,GO:0070062,GO:0071949,GO:0102797,GO:0102798" "aldehyde oxidase activity|xanthine dehydrogenase activity|iron ion binding|cytosol|electron transfer activity|xanthine catabolic process|drug metabolic process|electron transport chain|identical protein binding|protein homodimerization activity|vitamin B6 metabolic process|molybdopterin cofactor binding|flavin adenine dinucleotide binding|NAD binding|2 iron, 2 sulfur cluster binding|oxidation-reduction process|extracellular exosome|FAD binding|geranial:oxygen oxidoreductase activity|heptaldehyde:oxygen oxidoreductase activity" "hsa00280,hsa00350,hsa00380,hsa00750,hsa00760,hsa00830,hsa00982,hsa04630" "Valine, leucine and isoleucine degradation|Tyrosine metabolism|Tryptophan metabolism|Vitamin B6 metabolism|Nicotinate and nicotinamide metabolism|Retinol metabolism|Drug metabolism - cytochrome P450|JAK-STAT signaling pathway" AP1AR 444.5739708 419.1768149 469.9711267 1.121176339 0.165013203 0.698476181 1 6.791371372 7.942319126 55435 adaptor related protein complex 1 associated regulatory protein "GO:0001920,GO:0005768,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0015031,GO:0019894,GO:0030133,GO:0034315,GO:0034613,GO:0035650,GO:0048203,GO:1900025,GO:2000146" "negative regulation of receptor recycling|endosome|early endosome|late endosome|Golgi apparatus|cytosol|protein transport|kinesin binding|transport vesicle|regulation of Arp2/3 complex-mediated actin nucleation|cellular protein localization|AP-1 adaptor complex binding|vesicle targeting, trans-Golgi to endosome|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of cell motility" AP1B1 3113.21882 3218.425376 3008.012264 0.934622342 -0.097544569 0.759710906 1 39.13610837 38.15309083 162 adaptor related protein complex 1 subunit beta 1 "GO:0000139,GO:0001822,GO:0005515,GO:0005765,GO:0005794,GO:0005829,GO:0006886,GO:0007368,GO:0007507,GO:0016192,GO:0019886,GO:0019901,GO:0030131,GO:0030276,GO:0030659,GO:0030665,GO:0032588,GO:0043231,GO:0050690" Golgi membrane|kidney development|protein binding|lysosomal membrane|Golgi apparatus|cytosol|intracellular protein transport|determination of left/right symmetry|heart development|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|clathrin adaptor complex|clathrin binding|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|regulation of defense response to virus by virus "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1G1 1702.731152 2202.454451 1203.007853 0.546212364 -0.872466124 0.007926344 0.364181927 16.8728707 9.613165843 164 adaptor related protein complex 1 subunit gamma 1 "GO:0000139,GO:0005515,GO:0005737,GO:0005765,GO:0005794,GO:0005829,GO:0006886,GO:0006896,GO:0006898,GO:0016020,GO:0019886,GO:0019894,GO:0030121,GO:0030136,GO:0030659,GO:0030665,GO:0030742,GO:0031267,GO:0032438,GO:0032588,GO:0035615,GO:0035646,GO:0043231,GO:0043323,GO:0045954,GO:0050690,GO:0055037,GO:0090160,GO:0140312" Golgi membrane|protein binding|cytoplasm|lysosomal membrane|Golgi apparatus|cytosol|intracellular protein transport|Golgi to vacuole transport|receptor-mediated endocytosis|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|kinesin binding|AP-1 adaptor complex|clathrin-coated vesicle|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|GTP-dependent protein binding|small GTPase binding|melanosome organization|trans-Golgi network membrane|clathrin adaptor activity|endosome to melanosome transport|intracellular membrane-bounded organelle|positive regulation of natural killer cell degranulation|positive regulation of natural killer cell mediated cytotoxicity|regulation of defense response to virus by virus|recycling endosome|Golgi to lysosome transport|cargo adaptor activity "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1G2 1468.973083 1242.306105 1695.640061 1.364913248 0.448809258 0.177183619 1 17.71351961 25.21888267 8906 adaptor related protein complex 1 subunit gamma 2 "GO:0000139,GO:0005515,GO:0005794,GO:0005798,GO:0006886,GO:0006896,GO:0006898,GO:0010008,GO:0016020,GO:0016032,GO:0016192,GO:0030121,GO:0030133,GO:0035615,GO:0140312" Golgi membrane|protein binding|Golgi apparatus|Golgi-associated vesicle|intracellular protein transport|Golgi to vacuole transport|receptor-mediated endocytosis|endosome membrane|membrane|viral process|vesicle-mediated transport|AP-1 adaptor complex|transport vesicle|clathrin adaptor activity|cargo adaptor activity "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1M1 2199.973962 2046.151232 2353.796691 1.150353236 0.202076934 0.528612727 1 8.036474721 9.643012532 8907 adaptor related protein complex 1 subunit mu 1 "GO:0000139,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0006886,GO:0016020,GO:0016192,GO:0019886,GO:0030131,GO:0030136,GO:0030659,GO:0030665,GO:0031410,GO:0032438,GO:0032588,GO:0035579,GO:0035615,GO:0035646,GO:0043231,GO:0043312,GO:0050690,GO:0070062" Golgi membrane|protein binding|lysosomal membrane|cytosol|plasma membrane|intracellular protein transport|membrane|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|clathrin adaptor complex|clathrin-coated vesicle|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|cytoplasmic vesicle|melanosome organization|trans-Golgi network membrane|specific granule membrane|clathrin adaptor activity|endosome to melanosome transport|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of defense response to virus by virus|extracellular exosome "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1M2 151.9600878 116.7199364 187.2002391 1.603841169 0.681531276 0.248755874 1 2.973567914 4.974565445 10053 adaptor related protein complex 1 subunit mu 2 "GO:0000139,GO:0005515,GO:0005765,GO:0005829,GO:0006605,GO:0006903,GO:0016192,GO:0019886,GO:0030131,GO:0030136,GO:0030659,GO:0030665,GO:0031410,GO:0032588,GO:0035615,GO:0043231,GO:0050690" Golgi membrane|protein binding|lysosomal membrane|cytosol|protein targeting|vesicle targeting|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|clathrin adaptor complex|clathrin-coated vesicle|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|cytoplasmic vesicle|trans-Golgi network membrane|clathrin adaptor activity|intracellular membrane-bounded organelle|regulation of defense response to virus by virus "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1S1 1383.348113 1383.384985 1383.311241 0.999946693 -7.69E-05 1 1 57.14809885 59.60662956 1174 adaptor related protein complex 1 subunit sigma 1 "GO:0000139,GO:0005765,GO:0005794,GO:0005829,GO:0005905,GO:0006886,GO:0006898,GO:0009615,GO:0016020,GO:0016192,GO:0019886,GO:0030121,GO:0030659,GO:0032588,GO:0043231,GO:0050690" Golgi membrane|lysosomal membrane|Golgi apparatus|cytosol|clathrin-coated pit|intracellular protein transport|receptor-mediated endocytosis|response to virus|membrane|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|AP-1 adaptor complex|cytoplasmic vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|regulation of defense response to virus by virus "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1S2 1218.409603 1154.004936 1282.81427 1.111619396 0.152662913 0.655781422 1 10.44802984 12.11452666 8905 adaptor related protein complex 1 subunit sigma 2 "GO:0000139,GO:0005515,GO:0005765,GO:0005794,GO:0005829,GO:0005905,GO:0006886,GO:0016192,GO:0019886,GO:0030119,GO:0030659,GO:0032588,GO:0043231,GO:0050690" Golgi membrane|protein binding|lysosomal membrane|Golgi apparatus|cytosol|clathrin-coated pit|intracellular protein transport|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|AP-type membrane coat adaptor complex|cytoplasmic vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|regulation of defense response to virus by virus "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1S3 55.28813033 75.10674166 35.469519 0.472254796 -1.082362645 0.189640116 1 0.954312971 0.470092296 130340 adaptor related protein complex 1 subunit sigma 3 "GO:0000139,GO:0005515,GO:0005765,GO:0005829,GO:0005905,GO:0006605,GO:0016192,GO:0019886,GO:0030117,GO:0030659,GO:0032588,GO:0043231,GO:0050690" Golgi membrane|protein binding|lysosomal membrane|cytosol|clathrin-coated pit|protein targeting|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|membrane coat|cytoplasmic vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|regulation of defense response to virus by virus "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP2A1 3000.229625 2633.810738 3366.648511 1.278242382 0.354161428 0.265817913 1 30.94252432 41.25578773 160 adaptor related protein complex 2 subunit alpha 1 "GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0006895,GO:0006897,GO:0006898,GO:0008022,GO:0010976,GO:0016020,GO:0016323,GO:0016324,GO:0019886,GO:0019901,GO:0030122,GO:0030130,GO:0030666,GO:0030669,GO:0032433,GO:0032802,GO:0034383,GO:0035615,GO:0036020,GO:0044877,GO:0045334,GO:0048013,GO:0048260,GO:0050690,GO:0050750,GO:0060071,GO:0061024,GO:0072583,GO:0140312,GO:1900126" "protein binding|cytosol|plasma membrane|intracellular protein transport|Golgi to endosome transport|endocytosis|receptor-mediated endocytosis|protein C-terminus binding|positive regulation of neuron projection development|membrane|basolateral plasma membrane|apical plasma membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|filopodium tip|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|clathrin adaptor activity|endolysosome membrane|protein-containing complex binding|clathrin-coated endocytic vesicle|ephrin receptor signaling pathway|positive regulation of receptor-mediated endocytosis|regulation of defense response to virus by virus|low-density lipoprotein particle receptor binding|Wnt signaling pathway, planar cell polarity pathway|membrane organization|clathrin-dependent endocytosis|cargo adaptor activity|negative regulation of hyaluronan biosynthetic process" "hsa04144,hsa04721,hsa04961,hsa05016" Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2A2 2478.285181 2549.569393 2407.00097 0.944081372 -0.083016882 0.795646803 1 27.16740909 26.75306721 161 adaptor related protein complex 2 subunit alpha 2 "GO:0003674,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0006898,GO:0008289,GO:0019886,GO:0019901,GO:0030122,GO:0030666,GO:0030667,GO:0030669,GO:0031410,GO:0032802,GO:0034383,GO:0035615,GO:0036020,GO:0043312,GO:0045334,GO:0048013,GO:0050690,GO:0060071,GO:0061024,GO:0072583,GO:0097718,GO:0101003,GO:0140312" "molecular_function|protein binding|cytosol|plasma membrane|intracellular protein transport|receptor-mediated endocytosis|lipid binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|AP-2 adaptor complex|endocytic vesicle membrane|secretory granule membrane|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|clathrin adaptor activity|endolysosome membrane|neutrophil degranulation|clathrin-coated endocytic vesicle|ephrin receptor signaling pathway|regulation of defense response to virus by virus|Wnt signaling pathway, planar cell polarity pathway|membrane organization|clathrin-dependent endocytosis|disordered domain specific binding|ficolin-1-rich granule membrane|cargo adaptor activity" "hsa04144,hsa04721,hsa04961,hsa05016" Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2B1 11858.62029 11112.7529 12604.48768 1.134236296 0.181721228 0.594943916 1 85.90075257 101.6287161 163 adaptor related protein complex 2 subunit beta 1 "GO:0001822,GO:0003281,GO:0005048,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0016020,GO:0016192,GO:0019886,GO:0030122,GO:0030131,GO:0030276,GO:0030666,GO:0030669,GO:0032802,GO:0034383,GO:0035615,GO:0035904,GO:0036020,GO:0044877,GO:0045334,GO:0045807,GO:0048013,GO:0048268,GO:0050690,GO:0060071,GO:0060976,GO:0061024,GO:0072583,GO:0098794,GO:0098884,GO:0098978,GO:1901215,GO:1905477" "kidney development|ventricular septum development|signal sequence binding|protein binding|cytosol|plasma membrane|intracellular protein transport|membrane|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|AP-2 adaptor complex|clathrin adaptor complex|clathrin binding|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|clathrin adaptor activity|aorta development|endolysosome membrane|protein-containing complex binding|clathrin-coated endocytic vesicle|positive regulation of endocytosis|ephrin receptor signaling pathway|clathrin coat assembly|regulation of defense response to virus by virus|Wnt signaling pathway, planar cell polarity pathway|coronary vasculature development|membrane organization|clathrin-dependent endocytosis|postsynapse|postsynaptic neurotransmitter receptor internalization|glutamatergic synapse|negative regulation of neuron death|positive regulation of protein localization to membrane" "hsa04144,hsa04721,hsa04961,hsa05016" Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2M1 10162.15851 10753.45848 9570.858542 0.890026084 -0.168080477 0.617929742 1 271.4978745 252.0490694 1173 adaptor related protein complex 2 subunit mu 1 "GO:0005048,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0005905,GO:0006886,GO:0006897,GO:0006900,GO:0008289,GO:0016192,GO:0019886,GO:0030122,GO:0030666,GO:0030669,GO:0031410,GO:0031623,GO:0032802,GO:0034383,GO:0034622,GO:0035615,GO:0036020,GO:0043231,GO:0044325,GO:0045334,GO:0048013,GO:0050690,GO:0050750,GO:0060071,GO:0061024,GO:0070062,GO:0072583,GO:0097494,GO:1903077" "signal sequence binding|protein binding|lysosomal membrane|cytosol|plasma membrane|clathrin-coated pit|intracellular protein transport|endocytosis|vesicle budding from membrane|lipid binding|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|AP-2 adaptor complex|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle|receptor internalization|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|cellular protein-containing complex assembly|clathrin adaptor activity|endolysosome membrane|intracellular membrane-bounded organelle|ion channel binding|clathrin-coated endocytic vesicle|ephrin receptor signaling pathway|regulation of defense response to virus by virus|low-density lipoprotein particle receptor binding|Wnt signaling pathway, planar cell polarity pathway|membrane organization|extracellular exosome|clathrin-dependent endocytosis|regulation of vesicle size|negative regulation of protein localization to plasma membrane" "hsa04144,hsa04721,hsa04961,hsa05016" Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2S1 2095.309041 2266.396677 1924.221406 0.849022338 -0.236125583 0.462595726 1 108.2877324 95.89905021 1175 adaptor related protein complex 2 subunit sigma 1 "GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0016192,GO:0019886,GO:0030100,GO:0030122,GO:0030666,GO:0030669,GO:0032802,GO:0034383,GO:0035615,GO:0036020,GO:0043231,GO:0045334,GO:0048013,GO:0048268,GO:0050690,GO:0060071,GO:0061024,GO:0072583" "protein binding|cytosol|plasma membrane|intracellular protein transport|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|regulation of endocytosis|AP-2 adaptor complex|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|clathrin adaptor activity|endolysosome membrane|intracellular membrane-bounded organelle|clathrin-coated endocytic vesicle|ephrin receptor signaling pathway|clathrin coat assembly|regulation of defense response to virus by virus|Wnt signaling pathway, planar cell polarity pathway|membrane organization|clathrin-dependent endocytosis" "hsa04144,hsa04721,hsa04961,hsa05016" Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP3B1 2355.717247 2084.719559 2626.714935 1.259984789 0.333406318 0.296926905 1 12.99171788 17.07449286 8546 adaptor related protein complex 3 subunit beta 1 "GO:0000902,GO:0002224,GO:0002244,GO:0003016,GO:0005515,GO:0005739,GO:0005765,GO:0005794,GO:0006464,GO:0006622,GO:0006882,GO:0006886,GO:0006954,GO:0007040,GO:0007283,GO:0007338,GO:0007596,GO:0008089,GO:0016020,GO:0016182,GO:0016192,GO:0019903,GO:0030123,GO:0030131,GO:0030665,GO:0030742,GO:0030851,GO:0032438,GO:0034394,GO:0042789,GO:0045202,GO:0045944,GO:0048007,GO:0048490,GO:0048872,GO:0050790,GO:0051138,GO:0060155,GO:0060425,GO:0090152,GO:0098773,GO:1904115" "cell morphogenesis|toll-like receptor signaling pathway|hematopoietic progenitor cell differentiation|respiratory system process|protein binding|mitochondrion|lysosomal membrane|Golgi apparatus|cellular protein modification process|protein targeting to lysosome|cellular zinc ion homeostasis|intracellular protein transport|inflammatory response|lysosome organization|spermatogenesis|single fertilization|blood coagulation|anterograde axonal transport|membrane|synaptic vesicle budding from endosome|vesicle-mediated transport|protein phosphatase binding|AP-3 adaptor complex|clathrin adaptor complex|clathrin-coated vesicle membrane|GTP-dependent protein binding|granulocyte differentiation|melanosome organization|protein localization to cell surface|mRNA transcription by RNA polymerase II|synapse|positive regulation of transcription by RNA polymerase II|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|anterograde synaptic vesicle transport|homeostasis of number of cells|regulation of catalytic activity|positive regulation of NK T cell differentiation|platelet dense granule organization|lung morphogenesis|establishment of protein localization to mitochondrial membrane involved in mitochondrial fission|skin epidermis development|axon cytoplasm" hsa04142 Lysosome AP3B2 12.44941719 9.134603715 15.76423066 1.725770614 0.787240717 0.570104177 1 0.064469823 0.116052762 8120 adaptor related protein complex 3 subunit beta 2 "GO:0005794,GO:0006886,GO:0008089,GO:0016192,GO:0030123,GO:0030665,GO:0048490,GO:0097708,GO:1904115" Golgi apparatus|intracellular protein transport|anterograde axonal transport|vesicle-mediated transport|AP-3 adaptor complex|clathrin-coated vesicle membrane|anterograde synaptic vesicle transport|intracellular vesicle|axon cytoplasm hsa04142 Lysosome AP3D1 3450.88888 3671.095738 3230.682022 0.880032081 -0.184371978 0.562403796 1 36.60721565 33.60323829 8943 adaptor related protein complex 3 subunit delta 1 "GO:0000139,GO:0005515,GO:0005765,GO:0005794,GO:0006623,GO:0006886,GO:0006896,GO:0008089,GO:0010008,GO:0016020,GO:0016182,GO:0030123,GO:0032438,GO:0035646,GO:0043195,GO:0045944,GO:0048007,GO:0048490,GO:0048499,GO:0051138,GO:0061088,GO:0072657,GO:0098794,GO:0098830,GO:0098943,GO:0098978,GO:1904115" "Golgi membrane|protein binding|lysosomal membrane|Golgi apparatus|protein targeting to vacuole|intracellular protein transport|Golgi to vacuole transport|anterograde axonal transport|endosome membrane|membrane|synaptic vesicle budding from endosome|AP-3 adaptor complex|melanosome organization|endosome to melanosome transport|terminal bouton|positive regulation of transcription by RNA polymerase II|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|anterograde synaptic vesicle transport|synaptic vesicle membrane organization|positive regulation of NK T cell differentiation|regulation of sequestering of zinc ion|protein localization to membrane|postsynapse|presynaptic endosome|neurotransmitter receptor transport, postsynaptic endosome to lysosome|glutamatergic synapse|axon cytoplasm" hsa04142 Lysosome AP3M1 2680.337378 2386.161482 2974.513274 1.246568305 0.317961937 0.318422327 1 22.23563223 28.9122235 26985 adaptor related protein complex 3 subunit mu 1 "GO:0005515,GO:0005764,GO:0005765,GO:0005794,GO:0006622,GO:0006897,GO:0008089,GO:0016032,GO:0016192,GO:0030131,GO:0030659,GO:0031267,GO:0031410,GO:0043231,GO:0048490,GO:1904115" protein binding|lysosome|lysosomal membrane|Golgi apparatus|protein targeting to lysosome|endocytosis|anterograde axonal transport|viral process|vesicle-mediated transport|clathrin adaptor complex|cytoplasmic vesicle membrane|small GTPase binding|cytoplasmic vesicle|intracellular membrane-bounded organelle|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP3M2 439.0186829 443.5357582 434.5016077 0.979631517 -0.029688905 0.949731511 1 4.961025056 5.069324579 10947 adaptor related protein complex 3 subunit mu 2 "GO:0005794,GO:0006886,GO:0006897,GO:0008089,GO:0016192,GO:0030119,GO:0030131,GO:0030659,GO:0031410,GO:0043231,GO:0048490,GO:1904115" Golgi apparatus|intracellular protein transport|endocytosis|anterograde axonal transport|vesicle-mediated transport|AP-type membrane coat adaptor complex|clathrin adaptor complex|cytoplasmic vesicle membrane|cytoplasmic vesicle|intracellular membrane-bounded organelle|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP3S1 1204.244757 1128.631037 1279.858477 1.133991921 0.181410361 0.596589612 1 6.992193327 8.270643811 1176 adaptor related protein complex 3 subunit sigma 1 "GO:0005515,GO:0005794,GO:0006886,GO:0008089,GO:0008286,GO:0016192,GO:0030119,GO:0030123,GO:0030133,GO:0030659,GO:0043231,GO:0048490,GO:1904115" protein binding|Golgi apparatus|intracellular protein transport|anterograde axonal transport|insulin receptor signaling pathway|vesicle-mediated transport|AP-type membrane coat adaptor complex|AP-3 adaptor complex|transport vesicle|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP3S2 9.956564597 7.104691779 12.80843742 1.802813945 0.850250515 0.576368418 1 0.064915673 0.122072096 10239 adaptor related protein complex 3 subunit sigma 2 "GO:0005794,GO:0006886,GO:0008089,GO:0016192,GO:0030123,GO:0030659,GO:0043231,GO:0048490,GO:1904115" Golgi apparatus|intracellular protein transport|anterograde axonal transport|vesicle-mediated transport|AP-3 adaptor complex|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP4B1 470.0693578 444.5507141 495.5880015 1.114806446 0.156793249 0.708828631 1 6.182022348 7.18862736 10717 adaptor related protein complex 4 subunit beta 1 "GO:0005515,GO:0005802,GO:0005829,GO:0006605,GO:0008104,GO:0016192,GO:0019898,GO:0030124,GO:0030131,GO:0030276,GO:0031904,GO:0032588" protein binding|trans-Golgi network|cytosol|protein targeting|protein localization|vesicle-mediated transport|extrinsic component of membrane|AP-4 adaptor complex|clathrin adaptor complex|clathrin binding|endosome lumen|trans-Golgi network membrane hsa04142 Lysosome AP4E1 346.2635348 332.9055576 359.621512 1.080250851 0.111366368 0.810753238 1 3.439512867 3.875586955 23431 adaptor related protein complex 4 subunit epsilon 1 "GO:0005515,GO:0006605,GO:0006898,GO:0008104,GO:0030124,GO:0031904,GO:0032588,GO:0140312" protein binding|protein targeting|receptor-mediated endocytosis|protein localization|AP-4 adaptor complex|endosome lumen|trans-Golgi network membrane|cargo adaptor activity hsa04142 Lysosome AP4M1 401.2102123 384.668312 417.7521126 1.086006046 0.119032135 0.787972348 1 9.339450132 10.57960566 9179 adaptor related protein complex 4 subunit mu 1 "GO:0005515,GO:0005769,GO:0005802,GO:0005829,GO:0006605,GO:0006622,GO:0006886,GO:0006895,GO:0008104,GO:0016192,GO:0019904,GO:0030124,GO:0030131,GO:0031410,GO:0031904,GO:0032588,GO:0043231,GO:0070062,GO:0090160,GO:1903361" protein binding|early endosome|trans-Golgi network|cytosol|protein targeting|protein targeting to lysosome|intracellular protein transport|Golgi to endosome transport|protein localization|vesicle-mediated transport|protein domain specific binding|AP-4 adaptor complex|clathrin adaptor complex|cytoplasmic vesicle|endosome lumen|trans-Golgi network membrane|intracellular membrane-bounded organelle|extracellular exosome|Golgi to lysosome transport|protein localization to basolateral plasma membrane hsa04142 Lysosome AP4S1 118.1317689 127.884452 108.3790858 0.847476641 -0.238754491 0.718158705 1 0.914557518 0.808452839 11154 adaptor related protein complex 4 subunit sigma 1 "GO:0006605,GO:0008104,GO:0016192,GO:0030124,GO:0031904,GO:0032588,GO:0043231" protein targeting|protein localization|vesicle-mediated transport|AP-4 adaptor complex|endosome lumen|trans-Golgi network membrane|intracellular membrane-bounded organelle hsa04142 Lysosome AP5B1 1308.280465 1303.203463 1313.357467 1.007791572 0.011197297 0.976051879 1 9.455968194 9.940143513 91056 adaptor related protein complex 5 subunit beta 1 "GO:0005515,GO:0005765,GO:0015031,GO:0016197,GO:0030119" protein binding|lysosomal membrane|protein transport|endosomal transport|AP-type membrane coat adaptor complex AP5M1 809.9907787 748.0225487 871.9590086 1.16568546 0.221178555 0.54724322 1 3.217931133 3.912677515 55745 adaptor related protein complex 5 subunit mu 1 "GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0015031,GO:0016020,GO:0016197,GO:0030119,GO:0031902" lysosome|lysosomal membrane|late endosome|cytosol|protein transport|membrane|endosomal transport|AP-type membrane coat adaptor complex|late endosome membrane AP5S1 805.7743322 830.2339821 781.3146823 0.941077695 -0.087614258 0.813947828 1 7.909785987 7.76436857 55317 adaptor related protein complex 5 subunit sigma 1 "GO:0000724,GO:0005515,GO:0005654,GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0015031,GO:0016197,GO:0030119,GO:0031902" double-strand break repair via homologous recombination|protein binding|nucleoplasm|lysosome|lysosomal membrane|late endosome|cytosol|protein transport|endosomal transport|AP-type membrane coat adaptor complex|late endosome membrane AP5Z1 1027.412805 1029.165352 1025.660258 0.996594236 -0.004921865 0.991957863 1 9.427309531 9.799909553 9907 adaptor related protein complex 5 subunit zeta 1 "GO:0000724,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0015031,GO:0016197,GO:0016607,GO:0030119,GO:0044599" double-strand break repair via homologous recombination|protein binding|nucleus|nucleoplasm|cytoplasm|protein transport|endosomal transport|nuclear speck|AP-type membrane coat adaptor complex|AP-5 adaptor complex APAF1 959.7858587 1053.524295 866.0474221 0.822047888 -0.282705654 0.426169504 1 7.103886159 6.091286699 317 apoptotic peptidase activating factor 1 "GO:0000166,GO:0001666,GO:0001822,GO:0001843,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005829,GO:0006915,GO:0006919,GO:0007399,GO:0007568,GO:0007584,GO:0008635,GO:0008656,GO:0010659,GO:0030154,GO:0030900,GO:0031072,GO:0032991,GO:0034774,GO:0042802,GO:0042981,GO:0043065,GO:0043293,GO:0043312,GO:0043531,GO:0051402,GO:0070059,GO:0070062,GO:0070317,GO:0071560,GO:0072432,GO:0097193,GO:1902510,GO:1904813,GO:2001235" nucleotide binding|response to hypoxia|kidney development|neural tube closure|protein binding|ATP binding|extracellular region|nucleus|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|nervous system development|aging|response to nutrient|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|cysteine-type endopeptidase activator activity involved in apoptotic process|cardiac muscle cell apoptotic process|cell differentiation|forebrain development|heat shock protein binding|protein-containing complex|secretory granule lumen|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|apoptosome|neutrophil degranulation|ADP binding|neuron apoptotic process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|extracellular exosome|negative regulation of G0 to G1 transition|cellular response to transforming growth factor beta stimulus|response to G1 DNA damage checkpoint signaling|intrinsic apoptotic signaling pathway|regulation of apoptotic DNA fragmentation|ficolin-1-rich granule lumen|positive regulation of apoptotic signaling pathway "hsa01524,hsa04115,hsa04210,hsa04215,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05134,hsa05152,hsa05160,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05200,hsa05222" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Legionellosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Small cell lung cancer APBA1 121.5235329 90.33108119 152.7159846 1.690625005 0.757556693 0.23407868 1 0.634528515 1.118959483 320 amyloid beta precursor protein binding family A member 1 "GO:0001540,GO:0001701,GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006886,GO:0007155,GO:0007268,GO:0007269,GO:0007399,GO:0007626,GO:0008021,GO:0008088,GO:0010468,GO:0014047,GO:0014051,GO:0035264,GO:0043197,GO:0048471,GO:0048787,GO:0065003,GO:0098685,GO:0098978,GO:2000300" amyloid-beta binding|in utero embryonic development|protein binding|nucleus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|intracellular protein transport|cell adhesion|chemical synaptic transmission|neurotransmitter secretion|nervous system development|locomotory behavior|synaptic vesicle|axo-dendritic transport|regulation of gene expression|glutamate secretion|gamma-aminobutyric acid secretion|multicellular organism growth|dendritic spine|perinuclear region of cytoplasm|presynaptic active zone membrane|protein-containing complex assembly|Schaffer collateral - CA1 synapse|glutamatergic synapse|regulation of synaptic vesicle exocytosis APBA2 290.4058218 286.2175831 294.5940605 1.029266118 0.041616041 0.938123851 1 2.266402575 2.433215986 321 amyloid beta precursor protein binding family A member 2 "GO:0001540,GO:0005515,GO:0005737,GO:0005886,GO:0007268,GO:0007399,GO:0008021,GO:0015031,GO:0042802,GO:0043197" amyloid-beta binding|protein binding|cytoplasm|plasma membrane|chemical synaptic transmission|nervous system development|synaptic vesicle|protein transport|identical protein binding|dendritic spine APBA3 252.9833414 253.7389921 252.2276906 0.994043874 -0.008618566 0.995278063 1 5.919384989 6.137592772 9546 amyloid beta precursor protein binding family A member 3 "GO:0001540,GO:0001701,GO:0004857,GO:0005515,GO:0005737,GO:0005886,GO:0007268,GO:0010468,GO:0015031,GO:0019899,GO:0043086,GO:0043197,GO:0048471" amyloid-beta binding|in utero embryonic development|enzyme inhibitor activity|protein binding|cytoplasm|plasma membrane|chemical synaptic transmission|regulation of gene expression|protein transport|enzyme binding|negative regulation of catalytic activity|dendritic spine|perinuclear region of cytoplasm APBB1 1501.650112 1253.470621 1749.829604 1.395987728 0.481286259 0.146819195 1 17.73292318 25.82128568 322 amyloid beta precursor protein binding family B member 1 "GO:0000122,GO:0001540,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005886,GO:0006355,GO:0006915,GO:0006974,GO:0007050,GO:0007165,GO:0007409,GO:0008134,GO:0016607,GO:0030027,GO:0030308,GO:0030426,GO:0031625,GO:0042393,GO:0043065,GO:0043967,GO:0045202,GO:0045893,GO:0045944,GO:0050714,GO:0050750,GO:0070064" "negative regulation of transcription by RNA polymerase II|amyloid-beta binding|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|plasma membrane|regulation of transcription, DNA-templated|apoptotic process|cellular response to DNA damage stimulus|cell cycle arrest|signal transduction|axonogenesis|transcription factor binding|nuclear speck|lamellipodium|negative regulation of cell growth|growth cone|ubiquitin protein ligase binding|histone binding|positive regulation of apoptotic process|histone H4 acetylation|synapse|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of protein secretion|low-density lipoprotein particle receptor binding|proline-rich region binding" hsa05010 Alzheimer disease APBB2 1435.421391 1339.741878 1531.100903 1.142832756 0.192614293 0.56411106 1 6.044828491 7.20580645 323 amyloid beta precursor protein binding family B member 2 "GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0007050,GO:0008134,GO:0016020,GO:0030027,GO:0030308,GO:0030426,GO:0035556,GO:0045202,GO:0050808" "amyloid-beta binding|protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|cell cycle arrest|transcription factor binding|membrane|lamellipodium|negative regulation of cell growth|growth cone|intracellular signal transduction|synapse|synapse organization" APBB3 306.7193462 323.7709539 289.6677385 0.8946687 -0.16057455 0.737097023 1 7.61982185 7.110874131 10307 amyloid beta precursor protein binding family B member 3 "GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0008134,GO:0015629,GO:0016020,GO:0050714,GO:0050750" "amyloid-beta binding|protein binding|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription factor binding|actin cytoskeleton|membrane|positive regulation of protein secretion|low-density lipoprotein particle receptor binding" APC 1193.749539 1320.457715 1067.041363 0.808084463 -0.307422 0.369376045 1 5.847383489 4.928721325 324 APC regulator of WNT signaling pathway "GO:0000281,GO:0000776,GO:0001708,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005874,GO:0005881,GO:0005886,GO:0005912,GO:0005923,GO:0006974,GO:0007026,GO:0007050,GO:0007094,GO:0007155,GO:0007389,GO:0007399,GO:0008013,GO:0008017,GO:0008285,GO:0008286,GO:0010942,GO:0016055,GO:0016328,GO:0016342,GO:0016477,GO:0016579,GO:0019887,GO:0019901,GO:0030027,GO:0030335,GO:0030877,GO:0031274,GO:0031625,GO:0032587,GO:0032886,GO:0043065,GO:0045295,GO:0045296,GO:0045595,GO:0045732,GO:0045736,GO:0048471,GO:0051010,GO:0051988,GO:0065003,GO:0070830,GO:0070840,GO:0090090,GO:0120162,GO:1904781,GO:1904885,GO:1904886,GO:1990909,GO:2000134" mitotic cytokinesis|kinetochore|cell fate specification|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cytosol|microtubule|cytoplasmic microtubule|plasma membrane|adherens junction|bicellular tight junction|cellular response to DNA damage stimulus|negative regulation of microtubule depolymerization|cell cycle arrest|mitotic spindle assembly checkpoint|cell adhesion|pattern specification process|nervous system development|beta-catenin binding|microtubule binding|negative regulation of cell population proliferation|insulin receptor signaling pathway|positive regulation of cell death|Wnt signaling pathway|lateral plasma membrane|catenin complex|cell migration|protein deubiquitination|protein kinase regulator activity|protein kinase binding|lamellipodium|positive regulation of cell migration|beta-catenin destruction complex|positive regulation of pseudopodium assembly|ubiquitin protein ligase binding|ruffle membrane|regulation of microtubule-based process|positive regulation of apoptotic process|gamma-catenin binding|cadherin binding|regulation of cell differentiation|positive regulation of protein catabolic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|perinuclear region of cytoplasm|microtubule plus-end binding|regulation of attachment of spindle microtubules to kinetochore|protein-containing complex assembly|bicellular tight junction assembly|dynein complex binding|negative regulation of canonical Wnt signaling pathway|positive regulation of cold-induced thermogenesis|positive regulation of protein localization to centrosome|beta-catenin destruction complex assembly|beta-catenin destruction complex disassembly|Wnt signalosome|negative regulation of G1/S transition of mitotic cell cycle "hsa04310,hsa04390,hsa04550,hsa04810,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05206,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer other APC2 30.98857019 30.44867905 31.52846133 1.035462369 0.050275123 0.996837457 1 0.146561317 0.158295879 10297 APC regulator of WNT signaling pathway 2 "GO:0000226,GO:0001708,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005881,GO:0005884,GO:0007026,GO:0007389,GO:0007399,GO:0008013,GO:0008017,GO:0015630,GO:0016055,GO:0016342,GO:0016477,GO:0030496,GO:0030877,GO:0031258,GO:0031941,GO:0045171,GO:0045295,GO:0045595,GO:0045732,GO:0048471,GO:0090090,GO:0090630,GO:0098794" microtubule cytoskeleton organization|cell fate specification|protein binding|cytoplasm|Golgi apparatus|cytosol|cytoplasmic microtubule|actin filament|negative regulation of microtubule depolymerization|pattern specification process|nervous system development|beta-catenin binding|microtubule binding|microtubule cytoskeleton|Wnt signaling pathway|catenin complex|cell migration|midbody|beta-catenin destruction complex|lamellipodium membrane|filamentous actin|intercellular bridge|gamma-catenin binding|regulation of cell differentiation|positive regulation of protein catabolic process|perinuclear region of cytoplasm|negative regulation of canonical Wnt signaling pathway|activation of GTPase activity|postsynapse "hsa04310,hsa04390,hsa04550,hsa04810,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05206,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer APCDD1 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.020773465 0.005258604 147495 APC down-regulated 1 "GO:0001942,GO:0005515,GO:0005886,GO:0005887,GO:0016055,GO:0017147,GO:0030178,GO:0042802" hair follicle development|protein binding|plasma membrane|integral component of plasma membrane|Wnt signaling pathway|Wnt-protein binding|negative regulation of Wnt signaling pathway|identical protein binding APCDD1L 36.24422095 19.2841634 53.20427849 2.758962232 1.464125707 0.121407464 1 0.240678868 0.692627363 164284 APC down-regulated 1 like "GO:0005515,GO:0005886,GO:0016021,GO:0017147,GO:0030178" protein binding|plasma membrane|integral component of membrane|Wnt-protein binding|negative regulation of Wnt signaling pathway APEH 2982.085864 2706.887568 3257.284161 1.2033319 0.267034618 0.401434104 1 36.64643303 45.99737723 327 acylaminoacyl-peptide hydrolase "GO:0003723,GO:0004252,GO:0005515,GO:0005576,GO:0005829,GO:0006415,GO:0006508,GO:0008242,GO:0031965,GO:0042802,GO:0043312,GO:0050435,GO:0070062,GO:1904813" RNA binding|serine-type endopeptidase activity|protein binding|extracellular region|cytosol|translational termination|proteolysis|omega peptidase activity|nuclear membrane|identical protein binding|neutrophil degranulation|amyloid-beta metabolic process|extracellular exosome|ficolin-1-rich granule lumen APEX1 4131.757564 4146.095131 4117.419997 0.993083821 -0.010012601 0.975786365 1 151.3951635 156.8244734 328 apurinic/apyrimidinic endodeoxyribonuclease 1 "GO:0000723,GO:0000781,GO:0003677,GO:0003684,GO:0003691,GO:0003713,GO:0003714,GO:0003723,GO:0003906,GO:0004519,GO:0004520,GO:0004523,GO:0004528,GO:0004844,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0005739,GO:0005783,GO:0005813,GO:0005840,GO:0006281,GO:0006284,GO:0006286,GO:0006310,GO:0007568,GO:0008081,GO:0008309,GO:0008311,GO:0008408,GO:0014912,GO:0016491,GO:0016607,GO:0016890,GO:0031490,GO:0042493,GO:0042981,GO:0043488,GO:0044877,GO:0045454,GO:0045892,GO:0045944,GO:0046872,GO:0048471,GO:0051059,GO:0055114,GO:0070301,GO:0071320,GO:0071375,GO:0080111,GO:0090502,GO:0097698,GO:1900087" "telomere maintenance|chromosome, telomeric region|DNA binding|damaged DNA binding|double-stranded telomeric DNA binding|transcription coactivator activity|transcription corepressor activity|RNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|endonuclease activity|endodeoxyribonuclease activity|RNA-DNA hybrid ribonuclease activity|phosphodiesterase I activity|uracil DNA N-glycosylase activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|mitochondrion|endoplasmic reticulum|centrosome|ribosome|DNA repair|base-excision repair|base-excision repair, base-free sugar-phosphate removal|DNA recombination|aging|phosphoric diester hydrolase activity|double-stranded DNA exodeoxyribonuclease activity|double-stranded DNA 3'-5' exodeoxyribonuclease activity|3'-5' exonuclease activity|negative regulation of smooth muscle cell migration|oxidoreductase activity|nuclear speck|site-specific endodeoxyribonuclease activity, specific for altered base|chromatin DNA binding|response to drug|regulation of apoptotic process|regulation of mRNA stability|protein-containing complex binding|cell redox homeostasis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|perinuclear region of cytoplasm|NF-kappaB binding|oxidation-reduction process|cellular response to hydrogen peroxide|cellular response to cAMP|cellular response to peptide hormone stimulus|DNA demethylation|RNA phosphodiester bond hydrolysis, endonucleolytic|telomere maintenance via base-excision repair|positive regulation of G1/S transition of mitotic cell cycle" hsa03410 Base excision repair APEX2 1004.92047 973.3427737 1036.498166 1.064885048 0.090697703 0.798882507 1 15.21962882 16.90529368 27301 apurinic/apyrimidinic endodeoxyribonuclease 2 "GO:0001650,GO:0003677,GO:0003906,GO:0004519,GO:0004528,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006284,GO:0006310,GO:0007049,GO:0008270,GO:0008311,GO:0043231,GO:0090305" fibrillar center|DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|endonuclease activity|phosphodiesterase I activity|protein binding|nucleus|nucleoplasm|mitochondrion|base-excision repair|DNA recombination|cell cycle|zinc ion binding|double-stranded DNA 3'-5' exodeoxyribonuclease activity|intracellular membrane-bounded organelle|nucleic acid phosphodiester bond hydrolysis hsa03410 Base excision repair APH1A 3873.077404 3637.602191 4108.552617 1.12946727 0.175642465 0.581555814 1 76.16028039 89.72596017 51107 "aph-1 homolog A, gamma-secretase subunit" "GO:0001656,GO:0004175,GO:0005515,GO:0005739,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0006509,GO:0007219,GO:0007220,GO:0008021,GO:0010008,GO:0010950,GO:0016020,GO:0016021,GO:0016485,GO:0019899,GO:0030674,GO:0031293,GO:0032580,GO:0034205,GO:0035333,GO:0042982,GO:0042987,GO:0043065,GO:0043085,GO:0044267,GO:0048013,GO:0061133,GO:0070765,GO:0099056" "metanephros development|endopeptidase activity|protein binding|mitochondrion|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|membrane protein ectodomain proteolysis|Notch signaling pathway|Notch receptor processing|synaptic vesicle|endosome membrane|positive regulation of endopeptidase activity|membrane|integral component of membrane|protein processing|enzyme binding|protein-macromolecule adaptor activity|membrane protein intracellular domain proteolysis|Golgi cisterna membrane|amyloid-beta formation|Notch receptor processing, ligand-dependent|amyloid precursor protein metabolic process|amyloid precursor protein catabolic process|positive regulation of apoptotic process|positive regulation of catalytic activity|cellular protein metabolic process|ephrin receptor signaling pathway|endopeptidase activator activity|gamma-secretase complex|integral component of presynaptic membrane" "hsa04330,hsa05010" Notch signaling pathway|Alzheimer disease APH1B 351.9051758 348.1298972 355.6804544 1.021688908 0.030955979 0.951931858 1 3.652693425 3.892672177 83464 "aph-1 homolog B, gamma-secretase subunit" "GO:0004175,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0007219,GO:0007220,GO:0007626,GO:0008233,GO:0010008,GO:0010950,GO:0016021,GO:0016485,GO:0030133,GO:0030674,GO:0031293,GO:0034205,GO:0035333,GO:0042987,GO:0043065,GO:0044267,GO:0048013,GO:0061133,GO:0070765" "endopeptidase activity|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|Notch signaling pathway|Notch receptor processing|locomotory behavior|peptidase activity|endosome membrane|positive regulation of endopeptidase activity|integral component of membrane|protein processing|transport vesicle|protein-macromolecule adaptor activity|membrane protein intracellular domain proteolysis|amyloid-beta formation|Notch receptor processing, ligand-dependent|amyloid precursor protein catabolic process|positive regulation of apoptotic process|cellular protein metabolic process|ephrin receptor signaling pathway|endopeptidase activator activity|gamma-secretase complex" "hsa04330,hsa05010" Notch signaling pathway|Alzheimer disease API5 3410.860224 3561.480493 3260.239954 0.915417047 -0.127498937 0.688958045 1 25.7607002 24.59759172 8539 apoptosis inhibitor 5 "GO:0003723,GO:0005515,GO:0005634,GO:0005681,GO:0005737,GO:0006915,GO:0016020,GO:0016607,GO:0017134,GO:0043066,GO:2000270" RNA binding|protein binding|nucleus|spliceosomal complex|cytoplasm|apoptotic process|membrane|nuclear speck|fibroblast growth factor binding|negative regulation of apoptotic process|negative regulation of fibroblast apoptotic process APIP 782.5706379 894.1762081 670.9650677 0.750372311 -0.414321502 0.261651832 1 31.21079978 24.42854651 51074 APAF1 interacting protein "GO:0005515,GO:0005737,GO:0005829,GO:0006915,GO:0008270,GO:0019284,GO:0019509,GO:0042802,GO:0043066,GO:0046570,GO:0051289,GO:0070269,GO:0070372" protein binding|cytoplasm|cytosol|apoptotic process|zinc ion binding|L-methionine salvage from S-adenosylmethionine|L-methionine salvage from methylthioadenosine|identical protein binding|negative regulation of apoptotic process|methylthioribulose 1-phosphate dehydratase activity|protein homotetramerization|pyroptosis|regulation of ERK1 and ERK2 cascade hsa00270 Cysteine and methionine metabolism APLF 72.44118296 69.01700585 75.86536007 1.099227055 0.136489418 0.873280719 1 0.914325888 1.048345306 200558 aprataxin and PNKP like factor "GO:0000012,GO:0000166,GO:0003906,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006302,GO:0006974,GO:0008408,GO:0035861,GO:0046872,GO:0051106,GO:0090305" single strand break repair|nucleotide binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|cytosol|double-strand break repair|cellular response to DNA damage stimulus|3'-5' exonuclease activity|site of double-strand break|metal ion binding|positive regulation of DNA ligation|nucleic acid phosphodiester bond hydrolysis APLN 206.0563506 346.0999852 66.01271591 0.190733079 -2.39037302 2.17E-05 0.004991669 5.436955113 1.081677254 8862 apelin "GO:0001525,GO:0002026,GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0006955,GO:0007165,GO:0007186,GO:0007369,GO:0007595,GO:0010629,GO:0016032,GO:0031652,GO:0031704,GO:0040037,GO:0042327,GO:0042756,GO:0042802,GO:0043576,GO:0045776,GO:0045823,GO:0045906,GO:0048471,GO:0051461,GO:0051466,GO:0060183,GO:0060976,GO:1902895,GO:1904022,GO:1904706,GO:1905564" angiogenesis|regulation of the force of heart contraction|signaling receptor binding|hormone activity|extracellular region|extracellular space|immune response|signal transduction|G protein-coupled receptor signaling pathway|gastrulation|lactation|negative regulation of gene expression|viral process|positive regulation of heat generation|apelin receptor binding|negative regulation of fibroblast growth factor receptor signaling pathway|positive regulation of phosphorylation|drinking behavior|identical protein binding|regulation of respiratory gaseous exchange|negative regulation of blood pressure|positive regulation of heart contraction|negative regulation of vasoconstriction|perinuclear region of cytoplasm|positive regulation of corticotropin secretion|positive regulation of corticotropin-releasing hormone secretion|apelin receptor signaling pathway|coronary vasculature development|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of G protein-coupled receptor internalization|negative regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular endothelial cell proliferation "hsa04080,hsa04371" Neuroactive ligand-receptor interaction|Apelin signaling pathway APLP1 3.463271234 1.014955968 5.911586499 5.824475823 2.542128219 0.321345721 1 0.021652881 0.131549276 333 amyloid beta precursor like protein 1 "GO:0005515,GO:0005604,GO:0005654,GO:0005794,GO:0005886,GO:0006897,GO:0006915,GO:0007155,GO:0007399,GO:0008201,GO:0009887,GO:0016021,GO:0030198,GO:0030900,GO:0031694,GO:0031695,GO:0031696,GO:0042802,GO:0046914,GO:0048471,GO:0071874,GO:0106072" protein binding|basement membrane|nucleoplasm|Golgi apparatus|plasma membrane|endocytosis|apoptotic process|cell adhesion|nervous system development|heparin binding|animal organ morphogenesis|integral component of membrane|extracellular matrix organization|forebrain development|alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|identical protein binding|transition metal ion binding|perinuclear region of cytoplasm|cellular response to norepinephrine stimulus|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway APLP2 16499.55816 17737.3705 15261.74581 0.860428879 -0.216872148 0.540702255 1 229.5771128 206.0437748 334 amyloid beta precursor like protein 2 "GO:0002576,GO:0003677,GO:0004867,GO:0005515,GO:0005634,GO:0005788,GO:0005886,GO:0007186,GO:0008201,GO:0010951,GO:0016020,GO:0016021,GO:0031092,GO:0042802,GO:0043687,GO:0044267,GO:0046914,GO:0070062" platelet degranulation|DNA binding|serine-type endopeptidase inhibitor activity|protein binding|nucleus|endoplasmic reticulum lumen|plasma membrane|G protein-coupled receptor signaling pathway|heparin binding|negative regulation of endopeptidase activity|membrane|integral component of membrane|platelet alpha granule membrane|identical protein binding|post-translational protein modification|cellular protein metabolic process|transition metal ion binding|extracellular exosome APMAP 5490.781868 5415.805047 5565.758689 1.027688154 0.039402553 0.903312966 1 124.5646775 133.527952 57136 adipocyte plasma membrane associated protein "GO:0004064,GO:0005515,GO:0008150,GO:0009058,GO:0009986,GO:0016020,GO:0016021,GO:0016844" arylesterase activity|protein binding|biological_process|biosynthetic process|cell surface|membrane|integral component of membrane|strictosidine synthase activity APOBEC3A 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.03785268 0.11498453 200315 apolipoprotein B mRNA editing enzyme catalytic subunit 3A "GO:0000932,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0009972,GO:0010529,GO:0016554,GO:0044355,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0071466,GO:0080111" P-body|RNA binding|cytidine deaminase activity|protein binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|cytidine deamination|negative regulation of transposition|cytidine to uridine editing|clearance of foreign intracellular DNA|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|cellular response to xenobiotic stimulus|DNA demethylation hsa05170 Human immunodeficiency virus 1 infection APOBEC3B 681.870032 644.4970399 719.2430241 1.115975683 0.158305591 0.679010845 1 20.52924618 23.89701541 9582 apolipoprotein B mRNA editing enzyme catalytic subunit 3B "GO:0000932,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0009972,GO:0010529,GO:0016554,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111" P-body|RNA binding|cytidine deaminase activity|protein binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|cytidine deamination|negative regulation of transposition|cytidine to uridine editing|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation hsa05170 Human immunodeficiency virus 1 infection APOBEC3C 1011.759176 1137.765641 885.7527105 0.778501898 -0.361227539 0.304487273 1 21.62244499 17.55821676 27350 apolipoprotein B mRNA editing enzyme catalytic subunit 3C "GO:0000932,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0010529,GO:0016032,GO:0016554,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111" P-body|RNA binding|cytidine deaminase activity|protein binding|nucleus|cytoplasm|zinc ion binding|cytidine deamination|negative regulation of transposition|viral process|cytidine to uridine editing|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation hsa05170 Human immunodeficiency virus 1 infection APOBEC3D 166.1788739 213.1407534 119.2169944 0.559334583 -0.838216562 0.144005894 1 4.023416788 2.347375814 140564 apolipoprotein B mRNA editing enzyme catalytic subunit 3D "GO:0000932,GO:0003723,GO:0004126,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0010529,GO:0016554,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111" P-body|RNA binding|cytidine deaminase activity|nucleus|cytoplasm|zinc ion binding|cytidine deamination|negative regulation of transposition|cytidine to uridine editing|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation hsa05170 Human immunodeficiency virus 1 infection APOBEC3F 278.0966976 387.7131799 168.4802152 0.434548589 -1.202410594 0.013899891 0.521881214 2.52167777 1.142993771 200316 apolipoprotein B mRNA editing enzyme catalytic subunit 3F "GO:0000932,GO:0002230,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0010529,GO:0016553,GO:0016554,GO:0030895,GO:0042802,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0048525,GO:0051607,GO:0070383,GO:0080111,GO:1990904" P-body|positive regulation of defense response to virus by host|RNA binding|cytidine deaminase activity|protein binding|nucleus|cytoplasm|zinc ion binding|cytidine deamination|negative regulation of transposition|base conversion or substitution editing|cytidine to uridine editing|apolipoprotein B mRNA editing enzyme complex|identical protein binding|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|negative regulation of viral process|defense response to virus|DNA cytosine deamination|DNA demethylation|ribonucleoprotein complex hsa05170 Human immunodeficiency virus 1 infection APOBEC3G 249.7791293 371.4738844 128.0843742 0.344800481 -1.536166307 0.002628978 0.168080959 5.494696777 1.976184662 60489 apolipoprotein B mRNA editing enzyme catalytic subunit 3G "GO:0000932,GO:0002230,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008270,GO:0009972,GO:0010529,GO:0016032,GO:0016553,GO:0016554,GO:0030895,GO:0042802,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0048525,GO:0051607,GO:0070383,GO:0080111,GO:1990904" P-body|positive regulation of defense response to virus by host|RNA binding|cytidine deaminase activity|protein binding|nucleus|cytoplasm|cytosol|zinc ion binding|cytidine deamination|negative regulation of transposition|viral process|base conversion or substitution editing|cytidine to uridine editing|apolipoprotein B mRNA editing enzyme complex|identical protein binding|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|negative regulation of viral process|defense response to virus|DNA cytosine deamination|DNA demethylation|ribonucleoprotein complex hsa05170 Human immunodeficiency virus 1 infection APOBEC3H 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.173369104 0 164668 apolipoprotein B mRNA editing enzyme catalytic subunit 3H "GO:0000932,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008270,GO:0009972,GO:0010529,GO:0016554,GO:0045087,GO:0045869,GO:0047844,GO:0048525,GO:0051607,GO:0070383,GO:0080111" P-body|RNA binding|cytidine deaminase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|zinc ion binding|cytidine deamination|negative regulation of transposition|cytidine to uridine editing|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|negative regulation of viral process|defense response to virus|DNA cytosine deamination|DNA demethylation hsa05170 Human immunodeficiency virus 1 infection APOBR 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.067779456 0.054904709 55911 apolipoprotein B receptor "GO:0005886,GO:0006641,GO:0006869,GO:0006897,GO:0008203,GO:0016020,GO:0030229,GO:0034361,GO:0034362,GO:0034447,GO:0042627" plasma membrane|triglyceride metabolic process|lipid transport|endocytosis|cholesterol metabolic process|membrane|very-low-density lipoprotein particle receptor activity|very-low-density lipoprotein particle|low-density lipoprotein particle|very-low-density lipoprotein particle clearance|chylomicron APOC1 26.43611411 22.3290313 30.54319691 1.367869322 0.45193041 0.680728314 1 1.372435271 1.958179096 341 apolipoprotein C1 "GO:0004859,GO:0005504,GO:0005515,GO:0005576,GO:0005783,GO:0006629,GO:0006641,GO:0010873,GO:0010900,GO:0010916,GO:0031210,GO:0032374,GO:0032375,GO:0033344,GO:0033700,GO:0034361,GO:0034364,GO:0034369,GO:0034375,GO:0034379,GO:0034382,GO:0034447,GO:0042157,GO:0042627,GO:0045717,GO:0045833,GO:0048261,GO:0050995,GO:0051005,GO:0055102,GO:0060228" phospholipase inhibitor activity|fatty acid binding|protein binding|extracellular region|endoplasmic reticulum|lipid metabolic process|triglyceride metabolic process|positive regulation of cholesterol esterification|negative regulation of phosphatidylcholine catabolic process|negative regulation of very-low-density lipoprotein particle clearance|phosphatidylcholine binding|regulation of cholesterol transport|negative regulation of cholesterol transport|cholesterol efflux|phospholipid efflux|very-low-density lipoprotein particle|high-density lipoprotein particle|plasma lipoprotein particle remodeling|high-density lipoprotein particle remodeling|very-low-density lipoprotein particle assembly|chylomicron remnant clearance|very-low-density lipoprotein particle clearance|lipoprotein metabolic process|chylomicron|negative regulation of fatty acid biosynthetic process|negative regulation of lipid metabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of lipid catabolic process|negative regulation of lipoprotein lipase activity|lipase inhibitor activity|phosphatidylcholine-sterol O-acyltransferase activator activity hsa04979 Cholesterol metabolism APOE 6.985925571 6.08973581 7.882115332 1.294327961 0.372203218 0.905012836 1 0.23207196 0.31331626 348 apolipoprotein E "GO:0000302,GO:0001523,GO:0001540,GO:0001937,GO:0002021,GO:0005102,GO:0005198,GO:0005319,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005788,GO:0005794,GO:0005886,GO:0006357,GO:0006641,GO:0006707,GO:0006874,GO:0006898,GO:0007010,GO:0007186,GO:0007263,GO:0007271,GO:0007616,GO:0008201,GO:0008203,GO:0008289,GO:0010467,GO:0010544,GO:0010596,GO:0010629,GO:0010873,GO:0010875,GO:0010877,GO:0010976,GO:0010977,GO:0015909,GO:0016020,GO:0016209,GO:0017038,GO:0019068,GO:0019934,GO:0030195,GO:0030425,GO:0030516,GO:0030669,GO:0031012,GO:0031175,GO:0032269,GO:0032489,GO:0032805,GO:0033344,GO:0033700,GO:0034361,GO:0034362,GO:0034363,GO:0034364,GO:0034365,GO:0034371,GO:0034372,GO:0034374,GO:0034375,GO:0034378,GO:0034380,GO:0034382,GO:0034384,GO:0034447,GO:0035641,GO:0042158,GO:0042159,GO:0042311,GO:0042627,GO:0042632,GO:0042802,GO:0042803,GO:0042982,GO:0043025,GO:0043083,GO:0043254,GO:0043395,GO:0043407,GO:0043524,GO:0043537,GO:0043687,GO:0043691,GO:0044267,GO:0044794,GO:0044877,GO:0045088,GO:0045541,GO:0045807,GO:0045893,GO:0046889,GO:0046907,GO:0046911,GO:0046983,GO:0048156,GO:0048168,GO:0048844,GO:0050709,GO:0050728,GO:0050750,GO:0051000,GO:0051044,GO:0051246,GO:0051651,GO:0055089,GO:0060228,GO:0060999,GO:0061136,GO:0061771,GO:0062023,GO:0070062,GO:0070326,GO:0070328,GO:0070374,GO:0071682,GO:0071813,GO:0071830,GO:0071831,GO:0072562,GO:0090090,GO:0090181,GO:0090209,GO:0097113,GO:0097114,GO:0098869,GO:0098978,GO:0120009,GO:0120020,GO:1900221,GO:1900223,GO:1900272,GO:1902430,GO:1902952,GO:1902991,GO:1902995,GO:1903002,GO:1903561,GO:1905855,GO:1905860,GO:1905890,GO:1905906,GO:1905907,GO:1905908,GO:1990777,GO:2000822" "response to reactive oxygen species|retinoid metabolic process|amyloid-beta binding|negative regulation of endothelial cell proliferation|response to dietary excess|signaling receptor binding|structural molecule activity|lipid transporter activity|protein binding|phospholipid binding|extracellular region|extracellular space|nucleus|cytoplasm|early endosome|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|plasma membrane|regulation of transcription by RNA polymerase II|triglyceride metabolic process|cholesterol catabolic process|cellular calcium ion homeostasis|receptor-mediated endocytosis|cytoskeleton organization|G protein-coupled receptor signaling pathway|nitric oxide mediated signal transduction|synaptic transmission, cholinergic|long-term memory|heparin binding|cholesterol metabolic process|lipid binding|gene expression|negative regulation of platelet activation|negative regulation of endothelial cell migration|negative regulation of gene expression|positive regulation of cholesterol esterification|positive regulation of cholesterol efflux|lipid transport involved in lipid storage|positive regulation of neuron projection development|negative regulation of neuron projection development|long-chain fatty acid transport|membrane|antioxidant activity|protein import|virion assembly|cGMP-mediated signaling|negative regulation of blood coagulation|dendrite|regulation of axon extension|clathrin-coated endocytic vesicle membrane|extracellular matrix|neuron projection development|negative regulation of cellular protein metabolic process|regulation of Cdc42 protein signal transduction|positive regulation of low-density lipoprotein particle receptor catabolic process|cholesterol efflux|phospholipid efflux|very-low-density lipoprotein particle|low-density lipoprotein particle|intermediate-density lipoprotein particle|high-density lipoprotein particle|discoidal high-density lipoprotein particle|chylomicron remodeling|very-low-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|chylomicron assembly|high-density lipoprotein particle assembly|chylomicron remnant clearance|high-density lipoprotein particle clearance|very-low-density lipoprotein particle clearance|locomotory exploration behavior|lipoprotein biosynthetic process|lipoprotein catabolic process|vasodilation|chylomicron|cholesterol homeostasis|identical protein binding|protein homodimerization activity|amyloid precursor protein metabolic process|neuronal cell body|synaptic cleft|regulation of protein-containing complex assembly|heparan sulfate proteoglycan binding|negative regulation of MAP kinase activity|negative regulation of neuron apoptotic process|negative regulation of blood vessel endothelial cell migration|post-translational protein modification|reverse cholesterol transport|cellular protein metabolic process|positive regulation by host of viral process|protein-containing complex binding|regulation of innate immune response|negative regulation of cholesterol biosynthetic process|positive regulation of endocytosis|positive regulation of transcription, DNA-templated|positive regulation of lipid biosynthetic process|intracellular transport|metal chelating activity|protein dimerization activity|tau protein binding|regulation of neuronal synaptic plasticity|artery morphogenesis|negative regulation of protein secretion|negative regulation of inflammatory response|low-density lipoprotein particle receptor binding|positive regulation of nitric-oxide synthase activity|positive regulation of membrane protein ectodomain proteolysis|regulation of protein metabolic process|maintenance of location in cell|fatty acid homeostasis|phosphatidylcholine-sterol O-acyltransferase activator activity|positive regulation of dendritic spine development|regulation of proteasomal protein catabolic process|response to caloric restriction|collagen-containing extracellular matrix|extracellular exosome|very-low-density lipoprotein particle receptor binding|triglyceride homeostasis|positive regulation of ERK1 and ERK2 cascade|endocytic vesicle lumen|lipoprotein particle binding|triglyceride-rich lipoprotein particle clearance|intermediate-density lipoprotein particle clearance|blood microparticle|negative regulation of canonical Wnt signaling pathway|regulation of cholesterol metabolic process|negative regulation of triglyceride metabolic process|AMPA glutamate receptor clustering|NMDA glutamate receptor clustering|cellular oxidant detoxification|glutamatergic synapse|intermembrane lipid transfer|cholesterol transfer activity|regulation of amyloid-beta clearance|positive regulation of amyloid-beta clearance|negative regulation of long-term synaptic potentiation|negative regulation of amyloid-beta formation|positive regulation of dendritic spine maintenance|regulation of amyloid precursor protein catabolic process|positive regulation of phospholipid efflux|positive regulation of lipid transport across blood-brain barrier|extracellular vesicle|positive regulation of heparan sulfate binding|positive regulation of heparan sulfate proteoglycan binding|regulation of cellular response to very-low-density lipoprotein particle stimulus|regulation of amyloid fibril formation|negative regulation of amyloid fibril formation|positive regulation of amyloid fibril formation|lipoprotein particle|regulation of behavioral fear response" "hsa04979,hsa05010" Cholesterol metabolism|Alzheimer disease APOL1 198.930132 229.3800489 168.4802152 0.734502482 -0.445160729 0.411260419 1 3.587798107 2.748762351 8542 apolipoprotein L1 "GO:0005254,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006869,GO:0006898,GO:0008203,GO:0008289,GO:0031224,GO:0034361,GO:0034364,GO:0042157,GO:0043687,GO:0044267,GO:0045087,GO:0051838,GO:0072562,GO:1902476" chloride channel activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|lipid transport|receptor-mediated endocytosis|cholesterol metabolic process|lipid binding|intrinsic component of membrane|very-low-density lipoprotein particle|high-density lipoprotein particle|lipoprotein metabolic process|post-translational protein modification|cellular protein metabolic process|innate immune response|cytolysis by host of symbiont cells|blood microparticle|chloride transmembrane transport hsa05143 African trypanosomiasis APOL2 240.5608941 280.1278473 200.993941 0.717507891 -0.478933396 0.346263731 1 3.898732408 2.917870678 23780 apolipoprotein L2 "GO:0005102,GO:0005515,GO:0005576,GO:0005789,GO:0006629,GO:0006869,GO:0006953,GO:0007275,GO:0008035,GO:0008203,GO:0008289,GO:0016020,GO:0042157,GO:0060135" signaling receptor binding|protein binding|extracellular region|endoplasmic reticulum membrane|lipid metabolic process|lipid transport|acute-phase response|multicellular organism development|high-density lipoprotein particle binding|cholesterol metabolic process|lipid binding|membrane|lipoprotein metabolic process|maternal process involved in female pregnancy APOL3 35.49648894 35.52345889 35.469519 0.99848157 -0.002192297 1 1 0.36419795 0.37930929 80833 apolipoprotein L3 "GO:0005319,GO:0005576,GO:0005737,GO:0006869,GO:0006954,GO:0008289,GO:0016020,GO:0042157,GO:0043123" lipid transporter activity|extracellular region|cytoplasm|lipid transport|inflammatory response|lipid binding|membrane|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB signaling APOL6 743.2709087 632.3175683 854.2242491 1.350941824 0.433965549 0.244743662 1 3.105571582 4.376169359 80830 apolipoprotein L6 "GO:0005515,GO:0005576,GO:0005737,GO:0006869,GO:0008289,GO:0042157" protein binding|extracellular region|cytoplasm|lipid transport|lipid binding|lipoprotein metabolic process APOLD1 54.64704036 64.95718198 44.33689874 0.682555761 -0.550981185 0.510869186 1 0.689118582 0.490623139 81575 apolipoprotein L domain containing 1 "GO:0001525,GO:0001666,GO:0005576,GO:0005886,GO:0006869,GO:0008289,GO:0016021,GO:0030154,GO:0042118,GO:0042157,GO:0045601" angiogenesis|response to hypoxia|extracellular region|plasma membrane|lipid transport|lipid binding|integral component of membrane|cell differentiation|endothelial cell activation|lipoprotein metabolic process|regulation of endothelial cell differentiation APOM 13.52375626 15.22433953 11.823173 0.776596776 -0.364762376 0.820851526 1 0.841767564 0.681873324 55937 apolipoprotein M "GO:0001523,GO:0005319,GO:0005543,GO:0005576,GO:0009749,GO:0016209,GO:0033344,GO:0034361,GO:0034362,GO:0034364,GO:0034365,GO:0034366,GO:0034375,GO:0034380,GO:0034384,GO:0034445,GO:0042157,GO:0042632,GO:0043691,GO:0098869" retinoid metabolic process|lipid transporter activity|phospholipid binding|extracellular region|response to glucose|antioxidant activity|cholesterol efflux|very-low-density lipoprotein particle|low-density lipoprotein particle|high-density lipoprotein particle|discoidal high-density lipoprotein particle|spherical high-density lipoprotein particle|high-density lipoprotein particle remodeling|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|negative regulation of plasma lipoprotein oxidation|lipoprotein metabolic process|cholesterol homeostasis|reverse cholesterol transport|cellular oxidant detoxification APOO 208.2604524 227.3501369 189.170768 0.832067975 -0.265226703 0.622362581 1 7.064099627 6.131003332 79135 apolipoprotein O "GO:0000139,GO:0001401,GO:0005515,GO:0005576,GO:0005615,GO:0005739,GO:0005789,GO:0005829,GO:0006869,GO:0007007,GO:0031305,GO:0034361,GO:0034362,GO:0034364,GO:0042407,GO:0061617,GO:0140275" Golgi membrane|SAM complex|protein binding|extracellular region|extracellular space|mitochondrion|endoplasmic reticulum membrane|cytosol|lipid transport|inner mitochondrial membrane organization|integral component of mitochondrial inner membrane|very-low-density lipoprotein particle|low-density lipoprotein particle|high-density lipoprotein particle|cristae formation|MICOS complex|MIB complex APOOL 203.5743844 210.0958855 197.0528833 0.937918812 -0.092465049 0.871488426 1 9.244670221 9.044250861 139322 apolipoprotein O like "GO:0001401,GO:0002576,GO:0005515,GO:0005576,GO:0005739,GO:0007007,GO:0031093,GO:0042407,GO:0061617,GO:0140275" SAM complex|platelet degranulation|protein binding|extracellular region|mitochondrion|inner mitochondrial membrane organization|platelet alpha granule lumen|cristae formation|MICOS complex|MIB complex APP 21109.24047 21922.03396 20296.44698 0.925846891 -0.111154463 0.761774757 1 278.9632371 269.402782 351 amyloid beta precursor protein "GO:0000978,GO:0001774,GO:0001934,GO:0001967,GO:0002265,GO:0002576,GO:0003677,GO:0004867,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005641,GO:0005737,GO:0005768,GO:0005769,GO:0005788,GO:0005790,GO:0005791,GO:0005794,GO:0005796,GO:0005798,GO:0005829,GO:0005886,GO:0005887,GO:0005905,GO:0005911,GO:0006378,GO:0006417,GO:0006468,GO:0006878,GO:0006897,GO:0006979,GO:0007155,GO:0007176,GO:0007186,GO:0007219,GO:0007409,GO:0007611,GO:0007612,GO:0007617,GO:0007626,GO:0008021,GO:0008088,GO:0008201,GO:0008203,GO:0008285,GO:0008344,GO:0008542,GO:0009986,GO:0009987,GO:0010288,GO:0010468,GO:0010628,GO:0010629,GO:0010800,GO:0010951,GO:0010952,GO:0010971,GO:0014005,GO:0016021,GO:0016199,GO:0016322,GO:0016358,GO:0016504,GO:0019899,GO:0030111,GO:0030134,GO:0030198,GO:0030424,GO:0030546,GO:0030900,GO:0031093,GO:0031175,GO:0031594,GO:0031904,GO:0032092,GO:0032588,GO:0032722,GO:0032731,GO:0032755,GO:0032760,GO:0033138,GO:0035235,GO:0035253,GO:0040014,GO:0042327,GO:0042802,GO:0043197,GO:0043198,GO:0043204,GO:0043235,GO:0043687,GO:0044267,GO:0044304,GO:0045087,GO:0045121,GO:0045177,GO:0045202,GO:0045665,GO:0045821,GO:0045931,GO:0045944,GO:0046330,GO:0046914,GO:0048143,GO:0048169,GO:0048471,GO:0048669,GO:0048786,GO:0050729,GO:0050730,GO:0050803,GO:0050808,GO:0050885,GO:0050890,GO:0051091,GO:0051092,GO:0051124,GO:0051233,GO:0051247,GO:0051402,GO:0051425,GO:0051563,GO:0055037,GO:0070062,GO:0070374,GO:0070555,GO:0070851,GO:0071280,GO:0071287,GO:0071320,GO:0071874,GO:0090647,GO:0097449,GO:0098815,GO:0150003,GO:1900272,GO:1900273,GO:1901224,GO:1904646,GO:1905598,GO:1905606,GO:1905908,GO:1990000,GO:1990090,GO:1990535,GO:1990761,GO:1990812,GO:2000310,GO:2000406" RNA polymerase II cis-regulatory region sequence-specific DNA binding|microglial cell activation|positive regulation of protein phosphorylation|suckling behavior|astrocyte activation involved in immune response|platelet degranulation|DNA binding|serine-type endopeptidase inhibitor activity|signaling receptor binding|protein binding|extracellular region|extracellular space|nuclear envelope lumen|cytoplasm|endosome|early endosome|endoplasmic reticulum lumen|smooth endoplasmic reticulum|rough endoplasmic reticulum|Golgi apparatus|Golgi lumen|Golgi-associated vesicle|cytosol|plasma membrane|integral component of plasma membrane|clathrin-coated pit|cell-cell junction|mRNA polyadenylation|regulation of translation|protein phosphorylation|cellular copper ion homeostasis|endocytosis|response to oxidative stress|cell adhesion|regulation of epidermal growth factor-activated receptor activity|G protein-coupled receptor signaling pathway|Notch signaling pathway|axonogenesis|learning or memory|learning|mating behavior|locomotory behavior|synaptic vesicle|axo-dendritic transport|heparin binding|cholesterol metabolic process|negative regulation of cell population proliferation|adult locomotory behavior|visual learning|cell surface|cellular process|response to lead ion|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|negative regulation of endopeptidase activity|positive regulation of peptidase activity|positive regulation of G2/M transition of mitotic cell cycle|microglia development|integral component of membrane|axon midline choice point recognition|neuron remodeling|dendrite development|peptidase activator activity|enzyme binding|regulation of Wnt signaling pathway|COPII-coated ER to Golgi transport vesicle|extracellular matrix organization|axon|signaling receptor activator activity|forebrain development|platelet alpha granule lumen|neuron projection development|neuromuscular junction|endosome lumen|positive regulation of protein binding|trans-Golgi network membrane|positive regulation of chemokine production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of peptidyl-serine phosphorylation|ionotropic glutamate receptor signaling pathway|ciliary rootlet|regulation of multicellular organism growth|positive regulation of phosphorylation|identical protein binding|dendritic spine|dendritic shaft|perikaryon|receptor complex|post-translational protein modification|cellular protein metabolic process|main axon|innate immune response|membrane raft|apical part of cell|synapse|negative regulation of neuron differentiation|positive regulation of glycolytic process|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|transition metal ion binding|astrocyte activation|regulation of long-term neuronal synaptic plasticity|perinuclear region of cytoplasm|collateral sprouting in absence of injury|presynaptic active zone|positive regulation of inflammatory response|regulation of peptidyl-tyrosine phosphorylation|regulation of synapse structure or activity|synapse organization|neuromuscular process controlling balance|cognition|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|synaptic growth at neuromuscular junction|spindle midzone|positive regulation of protein metabolic process|neuron apoptotic process|PTB domain binding|smooth endoplasmic reticulum calcium ion homeostasis|recycling endosome|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|growth factor receptor binding|cellular response to copper ion|cellular response to manganese ion|cellular response to cAMP|cellular response to norepinephrine stimulus|modulation of age-related behavioral decline|astrocyte projection|modulation of excitatory postsynaptic potential|regulation of spontaneous synaptic transmission|negative regulation of long-term synaptic potentiation|positive regulation of long-term synaptic potentiation|positive regulation of NIK/NF-kappaB signaling|cellular response to amyloid-beta|negative regulation of low-density lipoprotein receptor activity|regulation of presynapse assembly|positive regulation of amyloid fibril formation|amyloid fibril formation|cellular response to nerve growth factor stimulus|neuron projection maintenance|growth cone lamellipodium|growth cone filopodium|regulation of NMDA receptor activity|positive regulation of T cell migration "hsa04726,hsa05010,hsa05022" Serotonergic synapse|Alzheimer disease|Pathways of neurodegeneration - multiple diseases APPBP2 1367.057599 1246.365929 1487.749269 1.193669719 0.255403708 0.446982885 1 9.666774487 12.03598655 10513 amyloid beta precursor protein binding protein 2 "GO:0003777,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005874,GO:0005875,GO:0006886,GO:0030659,GO:0046907" microtubule motor activity|protein binding|nucleus|nucleoplasm|cytoplasm|microtubule|microtubule associated complex|intracellular protein transport|cytoplasmic vesicle membrane|intracellular transport APPL1 1557.283655 1486.910494 1627.656816 1.09465689 0.130478741 0.693629718 1 12.29899902 14.04312338 26060 "adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1" "GO:0001726,GO:0001786,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006606,GO:0007049,GO:0007165,GO:0007179,GO:0008286,GO:0010008,GO:0010762,GO:0012506,GO:0016020,GO:0023052,GO:0031410,GO:0031901,GO:0032009,GO:0033211,GO:0034143,GO:0035091,GO:0035729,GO:0042802,GO:0042803,GO:0043422,GO:0044354,GO:0044877,GO:0045088,GO:0046324,GO:0046326,GO:0048023,GO:0048487,GO:0070062,GO:0097192,GO:0097708,GO:1900017,GO:1903076,GO:1905303,GO:1905450,GO:2000045" ruffle|phosphatidylserine binding|protein binding|nucleus|cytoplasm|endosome|early endosome|cytosol|plasma membrane|protein import into nucleus|cell cycle|signal transduction|transforming growth factor beta receptor signaling pathway|insulin receptor signaling pathway|endosome membrane|regulation of fibroblast migration|vesicle membrane|membrane|signaling|cytoplasmic vesicle|early endosome membrane|early phagosome|adiponectin-activated signaling pathway|regulation of toll-like receptor 4 signaling pathway|phosphatidylinositol binding|cellular response to hepatocyte growth factor stimulus|identical protein binding|protein homodimerization activity|protein kinase B binding|macropinosome|protein-containing complex binding|regulation of innate immune response|regulation of glucose import|positive regulation of glucose import|positive regulation of melanin biosynthetic process|beta-tubulin binding|extracellular exosome|extrinsic apoptotic signaling pathway in absence of ligand|intracellular vesicle|positive regulation of cytokine production involved in inflammatory response|regulation of protein localization to plasma membrane|positive regulation of macropinocytosis|negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of G1/S transition of mitotic cell cycle "hsa04211,hsa05200,hsa05210" Longevity regulating pathway|Pathways in cancer|Colorectal cancer APPL2 889.2100463 808.9199068 969.5001859 1.198511964 0.26124431 0.46859957 1 5.278142177 6.598411374 55198 "adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2" "GO:0001726,GO:0001786,GO:0002024,GO:0005515,GO:0005634,GO:0005768,GO:0005886,GO:0006606,GO:0007049,GO:0007165,GO:0007179,GO:0009631,GO:0010008,GO:0010762,GO:0016020,GO:0023052,GO:0031410,GO:0031901,GO:0031982,GO:0032009,GO:0032587,GO:0033211,GO:0034143,GO:0035091,GO:0035729,GO:0036186,GO:0042593,GO:0042802,GO:0042803,GO:0044354,GO:0044877,GO:0045088,GO:0046322,GO:0046325,GO:0050768,GO:0051289,GO:0060100,GO:0070062,GO:0120162,GO:1900016,GO:1900077,GO:1905303,GO:1905451,GO:2000045,GO:2000178" "ruffle|phosphatidylserine binding|diet induced thermogenesis|protein binding|nucleus|endosome|plasma membrane|protein import into nucleus|cell cycle|signal transduction|transforming growth factor beta receptor signaling pathway|cold acclimation|endosome membrane|regulation of fibroblast migration|membrane|signaling|cytoplasmic vesicle|early endosome membrane|vesicle|early phagosome|ruffle membrane|adiponectin-activated signaling pathway|regulation of toll-like receptor 4 signaling pathway|phosphatidylinositol binding|cellular response to hepatocyte growth factor stimulus|early phagosome membrane|glucose homeostasis|identical protein binding|protein homodimerization activity|macropinosome|protein-containing complex binding|regulation of innate immune response|negative regulation of fatty acid oxidation|negative regulation of glucose import|negative regulation of neurogenesis|protein homotetramerization|positive regulation of phagocytosis, engulfment|extracellular exosome|positive regulation of cold-induced thermogenesis|negative regulation of cytokine production involved in inflammatory response|negative regulation of cellular response to insulin stimulus|positive regulation of macropinocytosis|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of G1/S transition of mitotic cell cycle|negative regulation of neural precursor cell proliferation" APRT 781.4572047 818.0545105 744.8598989 0.910525997 -0.135227886 0.716229591 1 44.50222882 42.26589233 353 adenine phosphoribosyltransferase "GO:0002055,GO:0003999,GO:0005515,GO:0005576,GO:0005654,GO:0005737,GO:0005829,GO:0006166,GO:0006168,GO:0007595,GO:0007625,GO:0016208,GO:0032869,GO:0034774,GO:0043101,GO:0043312,GO:0044209,GO:0070062" adenine binding|adenine phosphoribosyltransferase activity|protein binding|extracellular region|nucleoplasm|cytoplasm|cytosol|purine ribonucleoside salvage|adenine salvage|lactation|grooming behavior|AMP binding|cellular response to insulin stimulus|secretory granule lumen|purine-containing compound salvage|neutrophil degranulation|AMP salvage|extracellular exosome hsa00230 Purine metabolism APTX 858.2281571 879.9668246 836.4894896 0.950592075 -0.073101721 0.842870111 1 5.091068692 5.047996857 54840 aprataxin "GO:0000012,GO:0000785,GO:0003682,GO:0003684,GO:0003690,GO:0003697,GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006266,GO:0006302,GO:0006974,GO:0008967,GO:0016311,GO:0030983,GO:0031647,GO:0033699,GO:0042542,GO:0046872,GO:0047485,GO:0051219,GO:0090305,GO:1990165" single strand break repair|chromatin|chromatin binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|double-stranded RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA ligation|double-strand break repair|cellular response to DNA damage stimulus|phosphoglycolate phosphatase activity|dephosphorylation|mismatched DNA binding|regulation of protein stability|DNA 5'-adenosine monophosphate hydrolase activity|response to hydrogen peroxide|metal ion binding|protein N-terminus binding|phosphoprotein binding|nucleic acid phosphodiester bond hydrolysis|single-strand break-containing DNA binding AQP11 26.07709388 31.46363502 20.69055275 0.657602109 -0.604713169 0.571512629 1 0.868404423 0.595663726 282679 aquaporin 11 "GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0006612,GO:0006811,GO:0006833,GO:0008284,GO:0009986,GO:0009992,GO:0015250,GO:0015254,GO:0015267,GO:0015793,GO:0015840,GO:0016021,GO:0030104,GO:0030425,GO:0030659,GO:0032364,GO:0033577,GO:0042802,GO:0048388,GO:0048471,GO:0050680,GO:0051260,GO:0072014,GO:0080170,GO:1903573,GO:1904293" cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|protein targeting to membrane|ion transport|water transport|positive regulation of cell population proliferation|cell surface|cellular water homeostasis|water channel activity|glycerol channel activity|channel activity|glycerol transport|urea transport|integral component of membrane|water homeostasis|dendrite|cytoplasmic vesicle membrane|oxygen homeostasis|protein glycosylation in endoplasmic reticulum|identical protein binding|endosomal lumen acidification|perinuclear region of cytoplasm|negative regulation of epithelial cell proliferation|protein homooligomerization|proximal tubule development|hydrogen peroxide transmembrane transport|negative regulation of response to endoplasmic reticulum stress|negative regulation of ERAD pathway AQP3 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.084499626 0.114081455 360 aquaporin 3 (Gill blood group) "GO:0002684,GO:0003091,GO:0005515,GO:0005654,GO:0005737,GO:0005886,GO:0005911,GO:0006833,GO:0015204,GO:0015250,GO:0015254,GO:0015793,GO:0016021,GO:0016323,GO:0032526,GO:0033280,GO:0042476,GO:0042802,GO:0045616,GO:0051592,GO:0070295,GO:0071456,GO:0071918,GO:0090650" positive regulation of immune system process|renal water homeostasis|protein binding|nucleoplasm|cytoplasm|plasma membrane|cell-cell junction|water transport|urea transmembrane transporter activity|water channel activity|glycerol channel activity|glycerol transport|integral component of membrane|basolateral plasma membrane|response to retinoic acid|response to vitamin D|odontogenesis|identical protein binding|regulation of keratinocyte differentiation|response to calcium ion|renal water absorption|cellular response to hypoxia|urea transmembrane transport|cellular response to oxygen-glucose deprivation hsa04962 Vasopressin-regulated water reabsorption AQR 1316.246212 1376.280293 1256.212131 0.912758932 -0.131694213 0.697529155 1 7.26307613 6.915006901 9716 aquarius intron-binding spliceosomal factor "GO:0000398,GO:0003723,GO:0003727,GO:0003729,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006283,GO:0016020,GO:0034458,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|mRNA binding|protein binding|ATP binding|nucleus|nucleoplasm|transcription-coupled nucleotide-excision repair|membrane|3'-5' RNA helicase activity|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome AR 132.284491 118.7498483 145.8191336 1.227952168 0.296254365 0.637691287 1 0.480027208 0.614841586 367 androgen receptor "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001085,GO:0001091,GO:0001225,GO:0001228,GO:0001701,GO:0003073,GO:0003382,GO:0003682,GO:0003700,GO:0004879,GO:0005102,GO:0005496,GO:0005497,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006367,GO:0007165,GO:0007267,GO:0007283,GO:0007338,GO:0008013,GO:0008134,GO:0008270,GO:0008284,GO:0008285,GO:0008584,GO:0010628,GO:0016579,GO:0016607,GO:0019102,GO:0019899,GO:0030518,GO:0030520,GO:0030521,GO:0030522,GO:0032991,GO:0033148,GO:0033327,GO:0035264,GO:0042327,GO:0043410,GO:0043568,GO:0045597,GO:0045720,GO:0045726,GO:0045893,GO:0045944,GO:0045945,GO:0048638,GO:0048645,GO:0048808,GO:0050680,GO:0051092,GO:0051117,GO:0060520,GO:0060571,GO:0060599,GO:0060736,GO:0060740,GO:0060742,GO:0060748,GO:0060749,GO:0060769,GO:0070974,GO:0071383,GO:0071391,GO:0071394,GO:0072520,GO:1903076,GO:2001237" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II general transcription initiation factor binding|RNA polymerase II transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|regulation of systemic arterial blood pressure|epithelial cell morphogenesis|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|signaling receptor binding|steroid binding|androgen binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|cell-cell signaling|spermatogenesis|single fertilization|beta-catenin binding|transcription factor binding|zinc ion binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|male gonad development|positive regulation of gene expression|protein deubiquitination|nuclear speck|male somatic sex determination|enzyme binding|intracellular steroid hormone receptor signaling pathway|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|intracellular receptor signaling pathway|protein-containing complex|positive regulation of intracellular estrogen receptor signaling pathway|Leydig cell differentiation|multicellular organism growth|positive regulation of phosphorylation|positive regulation of MAPK cascade|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of cell differentiation|negative regulation of integrin biosynthetic process|positive regulation of integrin biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase III|regulation of developmental growth|animal organ formation|male genitalia morphogenesis|negative regulation of epithelial cell proliferation|positive regulation of NF-kappaB transcription factor activity|ATPase binding|activation of prostate induction by androgen receptor signaling pathway|morphogenesis of an epithelial fold|lateral sprouting involved in mammary gland duct morphogenesis|prostate gland growth|prostate gland epithelium morphogenesis|epithelial cell differentiation involved in prostate gland development|tertiary branching involved in mammary gland duct morphogenesis|mammary gland alveolus development|positive regulation of epithelial cell proliferation involved in prostate gland development|POU domain binding|cellular response to steroid hormone stimulus|cellular response to estrogen stimulus|cellular response to testosterone stimulus|seminiferous tubule development|regulation of protein localization to plasma membrane|negative regulation of extrinsic apoptotic signaling pathway" "hsa04114,hsa05200,hsa05215" Oocyte meiosis|Pathways in cancer|Prostate cancer Androgen_rcpt ARAF 1946.99062 1792.41224 2101.569 1.172480835 0.229564341 0.477390725 1 30.13922866 36.85987141 369 "A-Raf proto-oncogene, serine/threonine kinase" "GO:0000165,GO:0000186,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005575,GO:0005739,GO:0005829,GO:0006464,GO:0006468,GO:0032006,GO:0032434,GO:0033138,GO:0043066,GO:0046872,GO:0106310,GO:0106311" MAPK cascade|activation of MAPKK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cellular_component|mitochondrion|cytosol|cellular protein modification process|protein phosphorylation|regulation of TOR signaling|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of peptidyl-serine phosphorylation|negative regulation of apoptotic process|metal ion binding|protein serine kinase activity|protein threonine kinase activity "hsa01521,hsa01522,hsa04010,hsa04012,hsa04068,hsa04270,hsa04650,hsa04720,hsa04726,hsa04730,hsa04810,hsa04910,hsa04914,hsa04928,hsa05010,hsa05022,hsa05034,hsa05160,hsa05161,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|FoxO signaling pathway|Vascular smooth muscle contraction|Natural killer cell mediated cytotoxicity|Long-term potentiation|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Parathyroid hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Hepatitis C|Hepatitis B|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" ARAP1 1909.865055 1780.232769 2039.497342 1.14563521 0.196147739 0.544574026 1 15.96644403 19.0796536 116985 "ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1" "GO:0001921,GO:0005096,GO:0005515,GO:0005547,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0007165,GO:0008360,GO:0030037,GO:0031410,GO:0031702,GO:0032580,GO:0043231,GO:0043547,GO:0045742,GO:0046872,GO:0051056,GO:0051270,GO:0051491,GO:0051497" "positive regulation of receptor recycling|GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|signal transduction|regulation of cell shape|actin filament reorganization involved in cell cycle|cytoplasmic vesicle|type 1 angiotensin receptor binding|Golgi cisterna membrane|intracellular membrane-bounded organelle|positive regulation of GTPase activity|positive regulation of epidermal growth factor receptor signaling pathway|metal ion binding|regulation of small GTPase mediated signal transduction|regulation of cellular component movement|positive regulation of filopodium assembly|negative regulation of stress fiber assembly" hsa04144 Endocytosis ARAP2 131.7648888 83.22638941 180.3033882 2.166420885 1.115313552 0.072995064 1 0.556305004 1.257105511 116984 "ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2" "GO:0005096,GO:0005547,GO:0005829,GO:0007165,GO:0043547,GO:0046872,GO:0051056" "GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|signal transduction|positive regulation of GTPase activity|metal ion binding|regulation of small GTPase mediated signal transduction" hsa04144 Endocytosis ARAP3 1224.965001 1130.660949 1319.269054 1.166812257 0.222572447 0.5145247 1 10.22936555 12.44989277 64411 "ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3" "GO:0001726,GO:0005096,GO:0005515,GO:0005547,GO:0005829,GO:0005856,GO:0005886,GO:0007010,GO:0007165,GO:0016192,GO:0030027,GO:0043325,GO:0043547,GO:0046872,GO:0051056" "ruffle|GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|cytoskeleton|plasma membrane|cytoskeleton organization|signal transduction|vesicle-mediated transport|lamellipodium|phosphatidylinositol-3,4-bisphosphate binding|positive regulation of GTPase activity|metal ion binding|regulation of small GTPase mediated signal transduction" "hsa04015,hsa04024,hsa04144" Rap1 signaling pathway|cAMP signaling pathway|Endocytosis ARC 59.27644692 44.65806261 73.89483124 1.654680632 0.726552791 0.369401481 1 0.766702823 1.323296535 23237 activity regulated cytoskeleton associated protein "GO:0001669,GO:0003729,GO:0005515,GO:0005737,GO:0005886,GO:0005938,GO:0006897,GO:0007010,GO:0007492,GO:0007612,GO:0007616,GO:0009952,GO:0015629,GO:0016477,GO:0022604,GO:0031901,GO:0043025,GO:0043197,GO:0045121,GO:0048168,GO:0050804,GO:0051028,GO:0051260,GO:0060291,GO:0060997,GO:0061001,GO:0071598,GO:0098839,GO:0098845,GO:0098978,GO:0099149,GO:0110077,GO:1900271,GO:1900452,GO:1903561,GO:2000969" acrosomal vesicle|mRNA binding|protein binding|cytoplasm|plasma membrane|cell cortex|endocytosis|cytoskeleton organization|endoderm development|learning|long-term memory|anterior/posterior pattern specification|actin cytoskeleton|cell migration|regulation of cell morphogenesis|early endosome membrane|neuronal cell body|dendritic spine|membrane raft|regulation of neuronal synaptic plasticity|modulation of chemical synaptic transmission|mRNA transport|protein homooligomerization|long-term synaptic potentiation|dendritic spine morphogenesis|regulation of dendritic spine morphogenesis|neuronal ribonucleoprotein granule|postsynaptic density membrane|postsynaptic endosome|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|vesicle-mediated intercellular transport|regulation of long-term synaptic potentiation|regulation of long-term synaptic depression|extracellular vesicle|positive regulation of AMPA receptor activity hsa05031 Amphetamine addiction ARCN1 6592.839958 6395.237557 6790.442359 1.061796735 0.086507611 0.7911601 1 80.83259825 89.52490199 372 archain 1 "GO:0000139,GO:0003723,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0016020,GO:0030126,GO:0030133,GO:0051645" "Golgi membrane|RNA binding|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|membrane|COPI vesicle coat|transport vesicle|Golgi localization" AREG 131.750043 82.21143344 181.2886526 2.20515134 1.140877672 0.066808865 1 3.37416457 7.761051963 374 amphiregulin "GO:0000139,GO:0000165,GO:0005125,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005789,GO:0006888,GO:0007165,GO:0007173,GO:0007186,GO:0007267,GO:0008083,GO:0008284,GO:0009986,GO:0010838,GO:0012507,GO:0016021,GO:0030665,GO:0033116,GO:0042059,GO:0045741,GO:0048208,GO:0051897,GO:0061024" Golgi membrane|MAPK cascade|cytokine activity|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|signal transduction|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|cell surface|positive regulation of keratinocyte proliferation|ER to Golgi transport vesicle membrane|integral component of membrane|clathrin-coated vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of epidermal growth factor-activated receptor activity|COPII vesicle coating|positive regulation of protein kinase B signaling|membrane organization "hsa04010,hsa04012,hsa04151,hsa04390,hsa05210" MAPK signaling pathway|ErbB signaling pathway|PI3K-Akt signaling pathway|Hippo signaling pathway|Colorectal cancer AREL1 2440.517288 2358.757671 2522.276906 1.069324305 0.09669946 0.76278518 1 21.6653527 24.16524104 9870 apoptosis resistant E3 ubiquitin protein ligase 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006511,GO:0006915,GO:0016567,GO:0043066,GO:0043161,GO:0045732,GO:0050727,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|protein ubiquitination|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|regulation of inflammatory response|ubiquitin protein ligase activity ARF1 10078.92148 10350.52097 9807.322002 0.94751965 -0.077772232 0.817486001 1 251.906474 248.9679733 375 ADP ribosylation factor 1 "GO:0000139,GO:0000287,GO:0002090,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005770,GO:0005778,GO:0005802,GO:0005829,GO:0005886,GO:0005925,GO:0006661,GO:0006878,GO:0006886,GO:0007015,GO:0014069,GO:0016192,GO:0019003,GO:0019886,GO:0019904,GO:0030017,GO:0030137,GO:0031252,GO:0032991,GO:0034315,GO:0034379,GO:0035722,GO:0043005,GO:0045807,GO:0045956,GO:0048471,GO:0050690,GO:0050714,GO:0050790,GO:0055108,GO:0060292,GO:0060999,GO:0070062,GO:0070142,GO:0097061,GO:0097212,GO:0098586,GO:0098974,GO:0098978,GO:1902307,GO:1902824,GO:1902953,GO:1903725,GO:1990386,GO:1990583" Golgi membrane|magnesium ion binding|regulation of receptor internalization|RNA binding|GTPase activity|protein binding|GTP binding|cytoplasm|late endosome|peroxisomal membrane|trans-Golgi network|cytosol|plasma membrane|focal adhesion|phosphatidylinositol biosynthetic process|cellular copper ion homeostasis|intracellular protein transport|actin filament organization|postsynaptic density|vesicle-mediated transport|GDP binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein domain specific binding|sarcomere|COPI-coated vesicle|cell leading edge|protein-containing complex|regulation of Arp2/3 complex-mediated actin nucleation|very-low-density lipoprotein particle assembly|interleukin-12-mediated signaling pathway|neuron projection|positive regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|perinuclear region of cytoplasm|regulation of defense response to virus by virus|positive regulation of protein secretion|regulation of catalytic activity|Golgi to transport vesicle transport|long-term synaptic depression|positive regulation of dendritic spine development|extracellular exosome|synaptic vesicle budding|dendritic spine organization|lysosomal membrane organization|cellular response to virus|postsynaptic actin cytoskeleton organization|glutamatergic synapse|positive regulation of sodium ion transmembrane transport|positive regulation of late endosome to lysosome transport|positive regulation of ER to Golgi vesicle-mediated transport|regulation of phospholipid metabolic process|mitotic cleavage furrow ingression|phospholipase D activator activity "hsa04072,hsa04144,hsa05110,hsa05130,hsa05131,hsa05132,hsa05134" Phospholipase D signaling pathway|Endocytosis|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Legionellosis ARF3 7962.661839 7426.432821 8498.890857 1.144410925 0.194605176 0.556018661 1 66.19546348 79.01802167 377 ADP ribosylation factor 3 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005886,GO:0006661,GO:0006886,GO:0006890,GO:0016192,GO:0048471,GO:0070062" "Golgi membrane|GTPase activity|protein binding|GTP binding|cytoplasm|plasma membrane|phosphatidylinositol biosynthetic process|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|vesicle-mediated transport|perinuclear region of cytoplasm|extracellular exosome" hsa04144 Endocytosis ARF4 4369.279033 4353.146148 4385.411918 1.007412058 0.010653904 0.974174885 1 138.1400347 145.1585546 378 ADP ribosylation factor 4 "GO:0003924,GO:0005154,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006471,GO:0006886,GO:0006888,GO:0006890,GO:0007173,GO:0007420,GO:0007612,GO:0016020,GO:0016192,GO:0016477,GO:0031584,GO:0032587,GO:0043066,GO:0043197,GO:0045176,GO:0045197,GO:0045944,GO:0048678,GO:0060996,GO:0061512,GO:0070062,GO:0098978,GO:0099175,GO:2000377" "GTPase activity|epidermal growth factor receptor binding|protein binding|GTP binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|protein ADP-ribosylation|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|epidermal growth factor receptor signaling pathway|brain development|learning|membrane|vesicle-mediated transport|cell migration|activation of phospholipase D activity|ruffle membrane|negative regulation of apoptotic process|dendritic spine|apical protein localization|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of transcription by RNA polymerase II|response to axon injury|dendritic spine development|protein localization to cilium|extracellular exosome|glutamatergic synapse|regulation of postsynapse organization|regulation of reactive oxygen species metabolic process" hsa04144 Endocytosis ARF5 2351.692312 2382.101658 2321.282965 0.974468473 -0.037312584 0.908323068 1 116.9041138 118.8265578 381 ADP ribosylation factor 5 "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0005886,GO:0006886,GO:0006890,GO:0016192,GO:0048471,GO:0070062" "GTPase activity|protein binding|GTP binding|cytoplasm|Golgi apparatus|plasma membrane|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|vesicle-mediated transport|perinuclear region of cytoplasm|extracellular exosome" hsa04144 Endocytosis ARF6 2532.079331 2455.178487 2608.980175 1.062643791 0.087658072 0.784298294 1 32.08932362 35.56838955 382 ADP ribosylation factor 6 "GO:0001726,GO:0001889,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0005938,GO:0006886,GO:0007049,GO:0007155,GO:0007399,GO:0016020,GO:0016192,GO:0019003,GO:0030139,GO:0030154,GO:0030838,GO:0030866,GO:0031527,GO:0031901,GO:0031996,GO:0032154,GO:0032456,GO:0033028,GO:0034394,GO:0035020,GO:0036010,GO:0047485,GO:0048261,GO:0048488,GO:0050714,GO:0051301,GO:0051489,GO:0051549,GO:0055038,GO:0060998,GO:0070062,GO:0090162,GO:0090543,GO:0097178,GO:0097284,GO:0098793,GO:0098978,GO:0099562,GO:0120183,GO:1903078,GO:1905606,GO:1990090,GO:2000009,GO:2000171" ruffle|liver development|GTPase activity|protein binding|GTP binding|cytoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|focal adhesion|cell cortex|intracellular protein transport|cell cycle|cell adhesion|nervous system development|membrane|vesicle-mediated transport|GDP binding|endocytic vesicle|cell differentiation|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|filopodium membrane|early endosome membrane|thioesterase binding|cleavage furrow|endocytic recycling|myeloid cell apoptotic process|protein localization to cell surface|regulation of Rac protein signal transduction|protein localization to endosome|protein N-terminus binding|negative regulation of receptor-mediated endocytosis|synaptic vesicle endocytosis|positive regulation of protein secretion|cell division|regulation of filopodium assembly|positive regulation of keratinocyte migration|recycling endosome membrane|regulation of dendritic spine development|extracellular exosome|establishment of epithelial cell polarity|Flemming body|ruffle assembly|hepatocyte apoptotic process|presynapse|glutamatergic synapse|maintenance of postsynaptic density structure|positive regulation of focal adhesion disassembly|positive regulation of protein localization to plasma membrane|regulation of presynapse assembly|cellular response to nerve growth factor stimulus|negative regulation of protein localization to cell surface|negative regulation of dendrite development "hsa04014,hsa04072,hsa04144,hsa04666,hsa05130,hsa05131,hsa05132,hsa05135" Ras signaling pathway|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARFGAP1 2989.434523 3209.290772 2769.578275 0.862987642 -0.212588195 0.504206665 1 43.68160599 39.3205065 55738 ADP ribosylation factor GTPase activating protein 1 "GO:0000139,GO:0005096,GO:0005515,GO:0005829,GO:0006888,GO:0006890,GO:0015031,GO:0030100,GO:0032012,GO:0036498,GO:0043547,GO:0045202,GO:0046872" "Golgi membrane|GTPase activator activity|protein binding|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|regulation of endocytosis|regulation of ARF protein signal transduction|IRE1-mediated unfolded protein response|positive regulation of GTPase activity|synapse|metal ion binding" hsa04144 Endocytosis ARFGAP2 1248.843436 1213.887338 1283.799535 1.057593645 0.080785413 0.814036217 1 21.50371156 23.72182994 84364 ADP ribosylation factor GTPase activating protein 2 "GO:0000139,GO:0005096,GO:0005794,GO:0005829,GO:0005886,GO:0006888,GO:0006890,GO:0015031,GO:0043547,GO:0046872,GO:0048205" "Golgi membrane|GTPase activator activity|Golgi apparatus|cytosol|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|positive regulation of GTPase activity|metal ion binding|COPI coating of Golgi vesicle" hsa04144 Endocytosis ARFGAP3 1117.069145 1062.658899 1171.479391 1.102403972 0.140652992 0.685722082 1 19.57800087 22.51256826 26286 ADP ribosylation factor GTPase activating protein 3 "GO:0000139,GO:0005096,GO:0005515,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0009306,GO:0016020,GO:0016192,GO:0043547,GO:0046872,GO:0048205" "Golgi membrane|GTPase activator activity|protein binding|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein secretion|membrane|vesicle-mediated transport|positive regulation of GTPase activity|metal ion binding|COPI coating of Golgi vesicle" hsa04144 Endocytosis ARFGEF1 4062.056661 3422.431525 4701.681796 1.373784037 0.458155226 0.151179903 1 20.39944488 29.23161059 10565 ADP ribosylation factor guanine nucleotide exchange factor 1 "GO:0000139,GO:0005085,GO:0005096,GO:0005515,GO:0005654,GO:0005730,GO:0005794,GO:0005802,GO:0005829,GO:0006887,GO:0007030,GO:0010256,GO:0015031,GO:0016363,GO:0017022,GO:0030532,GO:0030837,GO:0031175,GO:0032012,GO:0034237,GO:0034260,GO:0043547,GO:0048471,GO:0051897,GO:0090284,GO:0090303,GO:2000114" Golgi membrane|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleoplasm|nucleolus|Golgi apparatus|trans-Golgi network|cytosol|exocytosis|Golgi organization|endomembrane system organization|protein transport|nuclear matrix|myosin binding|small nuclear ribonucleoprotein complex|negative regulation of actin filament polymerization|neuron projection development|regulation of ARF protein signal transduction|protein kinase A regulatory subunit binding|negative regulation of GTPase activity|positive regulation of GTPase activity|perinuclear region of cytoplasm|positive regulation of protein kinase B signaling|positive regulation of protein glycosylation in Golgi|positive regulation of wound healing|regulation of establishment of cell polarity hsa04144 Endocytosis ARFGEF2 4027.828497 3945.133849 4110.523146 1.041922354 0.059247769 0.853172626 1 23.9490725 26.02795121 10564 ADP ribosylation factor guanine nucleotide exchange factor 2 "GO:0000139,GO:0001881,GO:0005085,GO:0005515,GO:0005794,GO:0005802,GO:0005815,GO:0005829,GO:0005879,GO:0006887,GO:0006893,GO:0007032,GO:0010256,GO:0015031,GO:0016020,GO:0017022,GO:0031410,GO:0032012,GO:0032279,GO:0032280,GO:0032760,GO:0034237,GO:0035556,GO:0043197,GO:0043231,GO:0048471,GO:0050790,GO:0050811,GO:0055037" Golgi membrane|receptor recycling|guanyl-nucleotide exchange factor activity|protein binding|Golgi apparatus|trans-Golgi network|microtubule organizing center|cytosol|axonemal microtubule|exocytosis|Golgi to plasma membrane transport|endosome organization|endomembrane system organization|protein transport|membrane|myosin binding|cytoplasmic vesicle|regulation of ARF protein signal transduction|asymmetric synapse|symmetric synapse|positive regulation of tumor necrosis factor production|protein kinase A regulatory subunit binding|intracellular signal transduction|dendritic spine|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|regulation of catalytic activity|GABA receptor binding|recycling endosome hsa04144 Endocytosis ARFGEF3 588.7016777 842.4134538 334.9899016 0.397654976 -1.330410871 0.000836207 0.080956814 2.871341919 1.190987661 57221 ARFGEF family member 3 "GO:0005085,GO:0010923,GO:0016021,GO:0030036,GO:0030658,GO:0032012" guanyl-nucleotide exchange factor activity|negative regulation of phosphatase activity|integral component of membrane|actin cytoskeleton organization|transport vesicle membrane|regulation of ARF protein signal transduction ARFIP1 470.1705567 485.1489529 455.1921604 0.938252382 -0.091952048 0.828995336 1 3.754749841 3.674655353 27236 ADP ribosylation factor interacting protein 1 "GO:0000139,GO:0005515,GO:0005543,GO:0005829,GO:0006886,GO:0019904,GO:0032588,GO:0034315,GO:0050708,GO:0070273,GO:1905280" "Golgi membrane|protein binding|phospholipid binding|cytosol|intracellular protein transport|protein domain specific binding|trans-Golgi network membrane|regulation of Arp2/3 complex-mediated actin nucleation|regulation of protein secretion|phosphatidylinositol-4-phosphate binding|negative regulation of retrograde transport, endosome to Golgi" ARFIP2 1552.415232 1692.946555 1411.883909 0.833980201 -0.26191496 0.427845723 1 46.04821196 40.05755537 23647 ADP ribosylation factor interacting protein 2 "GO:0001726,GO:0005515,GO:0005525,GO:0005543,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0006886,GO:0006914,GO:0007264,GO:0019904,GO:0030032,GO:0030036,GO:0030742,GO:0031267,GO:0031529,GO:0032588,GO:0034315,GO:0042802,GO:0045296,GO:0070273,GO:0140090" ruffle|protein binding|GTP binding|phospholipid binding|cytoplasm|cytosol|plasma membrane|cell cortex|intracellular protein transport|autophagy|small GTPase mediated signal transduction|protein domain specific binding|lamellipodium assembly|actin cytoskeleton organization|GTP-dependent protein binding|small GTPase binding|ruffle organization|trans-Golgi network membrane|regulation of Arp2/3 complex-mediated actin nucleation|identical protein binding|cadherin binding|phosphatidylinositol-4-phosphate binding|membrane curvature sensor activity ARFRP1 1257.883522 1293.053904 1222.713141 0.945601059 -0.080696443 0.814023364 1 25.20732048 24.86283012 10139 ADP ribosylation factor related protein 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0005802,GO:0005829,GO:0006886,GO:0007165,GO:0007369,GO:0016020,GO:0032588,GO:0033365,GO:0034067,GO:0042147,GO:0043001" "GTPase activity|protein binding|GTP binding|Golgi apparatus|trans-Golgi network|cytosol|intracellular protein transport|signal transduction|gastrulation|membrane|trans-Golgi network membrane|protein localization to organelle|protein localization to Golgi apparatus|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport" ARG2 140.4877702 208.0659735 72.90956682 0.350415619 -1.512861015 0.013894702 0.521881214 5.514289663 2.015528579 384 arginase 2 "GO:0000050,GO:0001657,GO:0002250,GO:0002829,GO:0004053,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0006809,GO:0006941,GO:0019547,GO:0030145,GO:0032651,GO:0032696,GO:0032700,GO:0032720,GO:0045087,GO:0071641,GO:0071644,GO:0071650,GO:1900425,GO:1903426,GO:1905403,GO:2000562,GO:2000774" "urea cycle|ureteric bud development|adaptive immune response|negative regulation of type 2 immune response|arginase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|nitric oxide biosynthetic process|striated muscle contraction|arginine catabolic process to ornithine|manganese ion binding|regulation of interleukin-1 beta production|negative regulation of interleukin-13 production|negative regulation of interleukin-17 production|negative regulation of tumor necrosis factor production|innate immune response|negative regulation of macrophage inflammatory protein 1 alpha production|negative regulation of chemokine (C-C motif) ligand 4 production|negative regulation of chemokine (C-C motif) ligand 5 production|negative regulation of defense response to bacterium|regulation of reactive oxygen species biosynthetic process|negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process|negative regulation of CD4-positive, alpha-beta T cell proliferation|positive regulation of cellular senescence" "hsa00220,hsa00330,hsa05146" Arginine biosynthesis|Arginine and proline metabolism|Amoebiasis ARGLU1 1149.337174 1146.900244 1151.774103 1.004249593 0.006117876 0.988683056 1 17.27221271 18.09279122 55082 arginine and glutamate rich 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0045296" protein binding|nucleoplasm|mitochondrion|cytosol|cadherin binding ARHGAP1 1680.865307 1785.307548 1576.423066 0.88299804 -0.179517859 0.583882224 1 21.43150726 19.73914718 392 Rho GTPase activating protein 1 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007264,GO:0007266,GO:0010008,GO:0016197,GO:0017124,GO:0031267,GO:0033572,GO:0043547,GO:0045296,GO:0048471,GO:0051056,GO:0070062,GO:0097443,GO:2001136" GTPase activator activity|protein binding|cytoplasm|cytosol|small GTPase mediated signal transduction|Rho protein signal transduction|endosome membrane|endosomal transport|SH3 domain binding|small GTPase binding|transferrin transport|positive regulation of GTPase activity|cadherin binding|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|extracellular exosome|sorting endosome|negative regulation of endocytic recycling ARHGAP10 308.1702729 288.247495 328.0930507 1.138233832 0.186796966 0.694545086 1 4.214410724 5.003619519 79658 Rho GTPase activating protein 10 "GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0007010,GO:0007165,GO:0043066,GO:0043547,GO:0048471,GO:0051056" GTPase activator activity|protein binding|cytosol|plasma membrane|cytoskeleton organization|signal transduction|negative regulation of apoptotic process|positive regulation of GTPase activity|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction hsa05100 Bacterial invasion of epithelial cells ARHGAP11A 1161.646298 1045.404647 1277.887948 1.222385945 0.289699861 0.399717946 1 8.468659217 10.79789089 9824 Rho GTPase activating protein 11A "GO:0005096,GO:0005829,GO:0007165,GO:0043547,GO:0051056" GTPase activator activity|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP11B 119.0131129 120.7797602 117.2464656 0.970745971 -0.042834281 0.960846386 1 3.908670141 3.957769956 89839 Rho GTPase activating protein 11B "GO:0005096,GO:0005829,GO:0007165,GO:0021987,GO:0043547,GO:0051056" GTPase activator activity|cytosol|signal transduction|cerebral cortex development|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP12 1323.782915 1217.947162 1429.618668 1.173793669 0.231178832 0.493352852 1 12.10216345 14.81735571 94134 Rho GTPase activating protein 12 "GO:0001891,GO:0002011,GO:0005096,GO:0005737,GO:0005829,GO:0006911,GO:0007015,GO:0007165,GO:0043087,GO:0043547,GO:0051056,GO:0051058" "phagocytic cup|morphogenesis of an epithelial sheet|GTPase activator activity|cytoplasm|cytosol|phagocytosis, engulfment|actin filament organization|signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|negative regulation of small GTPase mediated signal transduction" ARHGAP17 772.4116756 805.8750389 738.9483124 0.916951483 -0.125082693 0.73760407 1 10.07025111 9.631692026 55114 Rho GTPase activating protein 17 "GO:0005096,GO:0005515,GO:0005622,GO:0005654,GO:0005829,GO:0005886,GO:0005923,GO:0007015,GO:0007165,GO:0017124,GO:0017156,GO:0032956,GO:0035020,GO:0043547,GO:0051056" GTPase activator activity|protein binding|intracellular anatomical structure|nucleoplasm|cytosol|plasma membrane|bicellular tight junction|actin filament organization|signal transduction|SH3 domain binding|calcium-ion regulated exocytosis|regulation of actin cytoskeleton organization|regulation of Rac protein signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction hsa04530 Tight junction ARHGAP18 1367.604171 1317.412847 1417.795495 1.076196804 0.105941927 0.753673536 1 14.07643737 15.80157512 93663 Rho GTPase activating protein 18 "GO:0001726,GO:0005096,GO:0005737,GO:0005829,GO:0005881,GO:0005886,GO:0007264,GO:0008360,GO:0016607,GO:0030833,GO:0032956,GO:0043547,GO:0045296,GO:0051056,GO:2000145" ruffle|GTPase activator activity|cytoplasm|cytosol|cytoplasmic microtubule|plasma membrane|small GTPase mediated signal transduction|regulation of cell shape|nuclear speck|regulation of actin filament polymerization|regulation of actin cytoskeleton organization|positive regulation of GTPase activity|cadherin binding|regulation of small GTPase mediated signal transduction|regulation of cell motility ARHGAP19 1420.496688 1296.098772 1544.894605 1.191957464 0.253332753 0.448314664 1 11.95679971 14.86591488 84986 Rho GTPase activating protein 19 "GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0043231,GO:0043547,GO:0051056" GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|signal transduction|intracellular membrane-bounded organelle|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP21 3298.636328 2928.147969 3669.124687 1.253053031 0.325447473 0.306351628 1 13.97873171 18.27061435 57584 Rho GTPase activating protein 21 "GO:0000139,GO:0005096,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0007030,GO:0007165,GO:0015629,GO:0030054,GO:0030659,GO:0043547,GO:0051056,GO:0051645,GO:0051683,GO:0051684,GO:0072384" Golgi membrane|GTPase activator activity|protein binding|Golgi apparatus|cytosol|plasma membrane|Golgi organization|signal transduction|actin cytoskeleton|cell junction|cytoplasmic vesicle membrane|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|Golgi localization|establishment of Golgi localization|maintenance of Golgi location|organelle transport along microtubule ARHGAP22 611.8784021 742.9477688 480.8090353 0.64716398 -0.627796782 0.107081847 1 4.49554164 3.034675733 58504 Rho GTPase activating protein 22 "GO:0001525,GO:0005096,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0007165,GO:0030154,GO:0051056,GO:0090630,GO:0098978,GO:0099175" angiogenesis|GTPase activator activity|protein binding|nucleus|cytosol|focal adhesion|signal transduction|cell differentiation|regulation of small GTPase mediated signal transduction|activation of GTPase activity|glutamatergic synapse|regulation of postsynapse organization ARHGAP23 1097.783744 855.6078813 1339.959607 1.566090771 0.647167834 0.062611275 1 6.62288259 10.81882052 57636 Rho GTPase activating protein 23 "GO:0005096,GO:0005829,GO:0007165,GO:0043547,GO:0051056,GO:0070062" GTPase activator activity|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|extracellular exosome ARHGAP24 126.9721787 92.36099312 161.5833643 1.749476255 0.806923083 0.198410729 1 0.290057572 0.529307673 83478 Rho GTPase activating protein 24 "GO:0001525,GO:0005096,GO:0005515,GO:0005829,GO:0005856,GO:0005912,GO:0005925,GO:0007165,GO:0030154,GO:0035021,GO:0035313,GO:0042995,GO:0051056,GO:0090630,GO:1900028" "angiogenesis|GTPase activator activity|protein binding|cytosol|cytoskeleton|adherens junction|focal adhesion|signal transduction|cell differentiation|negative regulation of Rac protein signal transduction|wound healing, spreading of epidermal cells|cell projection|regulation of small GTPase mediated signal transduction|activation of GTPase activity|negative regulation of ruffle assembly" ARHGAP26 221.5412331 293.3222749 149.7601913 0.510565355 -0.96983245 0.063872417 1 1.326050026 0.706199133 23092 Rho GTPase activating protein 26 "GO:0005096,GO:0005515,GO:0005543,GO:0005575,GO:0005829,GO:0005856,GO:0005925,GO:0007165,GO:0007399,GO:0030036,GO:0043547,GO:0051056" GTPase activator activity|protein binding|phospholipid binding|cellular_component|cytosol|cytoskeleton|focal adhesion|signal transduction|nervous system development|actin cytoskeleton organization|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP27 423.316557 414.1020351 432.5310789 1.04450363 0.062817506 0.888288052 1 3.514799265 3.829361885 201176 Rho GTPase activating protein 27 "GO:0005096,GO:0005737,GO:0006898,GO:0007165,GO:0016020,GO:0017124,GO:0043087,GO:0043547" GTPase activator activity|cytoplasm|receptor-mediated endocytosis|signal transduction|membrane|SH3 domain binding|regulation of GTPase activity|positive regulation of GTPase activity ARHGAP29 9083.426344 8573.333065 9593.519624 1.118995326 0.16220401 0.627083424 1 47.2428544 55.14172294 9411 Rho GTPase activating protein 29 "GO:0005096,GO:0005737,GO:0005829,GO:0007266,GO:0030165,GO:0032991,GO:0046872,GO:0051056,GO:0090630" GTPase activator activity|cytoplasm|cytosol|Rho protein signal transduction|PDZ domain binding|protein-containing complex|metal ion binding|regulation of small GTPase mediated signal transduction|activation of GTPase activity ARHGAP31 463.2764274 451.6554059 474.8974488 1.05145968 0.072393529 0.866805982 1 2.433225504 2.668645666 57514 Rho GTPase activating protein 31 "GO:0005096,GO:0005829,GO:0005925,GO:0007264,GO:0017124,GO:0030027,GO:0043547,GO:0051056" GTPase activator activity|cytosol|focal adhesion|small GTPase mediated signal transduction|SH3 domain binding|lamellipodium|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP32 555.5240975 561.2706505 549.7775444 0.979523059 -0.02984864 0.945007014 1 2.116475199 2.162438564 9743 Rho GTPase activating protein 32 "GO:0000139,GO:0001650,GO:0005096,GO:0005515,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0005938,GO:0007264,GO:0010008,GO:0014069,GO:0015629,GO:0043197,GO:0043547,GO:0051056,GO:1901981" Golgi membrane|fibrillar center|GTPase activator activity|protein binding|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|cell cortex|small GTPase mediated signal transduction|endosome membrane|postsynaptic density|actin cytoskeleton|dendritic spine|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|phosphatidylinositol phosphate binding ARHGAP33 112.8964071 73.07682972 152.7159846 2.089800353 1.063365123 0.104025401 1 0.530393182 1.15616192 115703 Rho GTPase activating protein 33 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007264,GO:0009636,GO:0015031,GO:0019901,GO:0032991,GO:0035091,GO:0043197,GO:0043547,GO:0051056,GO:0061001" GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|small GTPase mediated signal transduction|response to toxic substance|protein transport|protein kinase binding|protein-containing complex|phosphatidylinositol binding|dendritic spine|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|regulation of dendritic spine morphogenesis ARHGAP35 2871.324527 2813.457944 2929.19111 1.041135559 0.058157925 0.855923677 1 14.79203982 16.06391054 2909 Rho GTPase activating protein 35 "GO:0001843,GO:0003677,GO:0003924,GO:0005096,GO:0005525,GO:0005543,GO:0005634,GO:0005829,GO:0005886,GO:0007165,GO:0007411,GO:0007413,GO:0008064,GO:0008360,GO:0010976,GO:0015629,GO:0016477,GO:0021955,GO:0030879,GO:0030900,GO:0030950,GO:0031668,GO:0032956,GO:0035024,GO:0036064,GO:0043010,GO:0043116,GO:0043547,GO:0044319,GO:0045724,GO:0050770,GO:0051056,GO:0097485" "neural tube closure|DNA binding|GTPase activity|GTPase activator activity|GTP binding|phospholipid binding|nucleus|cytosol|plasma membrane|signal transduction|axon guidance|axonal fasciculation|regulation of actin polymerization or depolymerization|regulation of cell shape|positive regulation of neuron projection development|actin cytoskeleton|cell migration|central nervous system neuron axonogenesis|mammary gland development|forebrain development|establishment or maintenance of actin cytoskeleton polarity|cellular response to extracellular stimulus|regulation of actin cytoskeleton organization|negative regulation of Rho protein signal transduction|ciliary basal body|camera-type eye development|negative regulation of vascular permeability|positive regulation of GTPase activity|wound healing, spreading of cells|positive regulation of cilium assembly|regulation of axonogenesis|regulation of small GTPase mediated signal transduction|neuron projection guidance" "hsa04510,hsa04611,hsa04670,hsa04810" Focal adhesion|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton ARHGAP39 712.9437175 546.046311 879.841124 1.611293962 0.688219721 0.067880075 1 3.971753456 6.675333863 80728 Rho GTPase activating protein 39 "GO:0005096,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0007165,GO:0043547,GO:0051056,GO:0098978,GO:0099173" GTPase activator activity|nucleus|cytoplasm|cytosol|cytoskeleton|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|glutamatergic synapse|postsynapse organization ARHGAP4 28.10700582 35.52345889 20.69055275 0.582447582 -0.779799875 0.446543728 1 0.533235884 0.323960562 393 Rho GTPase activating protein 4 "GO:0005096,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005874,GO:0007010,GO:0007266,GO:0010764,GO:0030336,GO:0030426,GO:0030517,GO:0043547,GO:0051056" GTPase activator activity|protein binding|cytoplasm|Golgi apparatus|cytosol|microtubule|cytoskeleton organization|Rho protein signal transduction|negative regulation of fibroblast migration|negative regulation of cell migration|growth cone|negative regulation of axon extension|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP40 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.086713798 0.087803076 343578 Rho GTPase activating protein 40 "GO:0005096,GO:0005737,GO:0005829,GO:0007165,GO:0030833,GO:0043547,GO:0051056" GTPase activator activity|cytoplasm|cytosol|signal transduction|regulation of actin filament polymerization|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP42 117.2504249 134.9891438 99.51170607 0.73718303 -0.439905234 0.497562298 1 0.564179231 0.433818785 143872 Rho GTPase activating protein 42 "GO:0003085,GO:0005096,GO:0005575,GO:0007165,GO:0035024,GO:0090630,GO:1904694" negative regulation of systemic arterial blood pressure|GTPase activator activity|cellular_component|signal transduction|negative regulation of Rho protein signal transduction|activation of GTPase activity|negative regulation of vascular associated smooth muscle contraction ARHGAP44 24.55465993 28.41876711 20.69055275 0.728059478 -0.457871781 0.684608279 1 0.33294247 0.252843613 9912 Rho GTPase activating protein 44 "GO:0005096,GO:0005515,GO:0005543,GO:0005622,GO:0005829,GO:0006887,GO:0007165,GO:0014069,GO:0030425,GO:0031256,GO:0032956,GO:0035020,GO:0035021,GO:0043087,GO:0043197,GO:0043547,GO:0048786,GO:0051056,GO:0051490,GO:0055037,GO:0061001,GO:0098886,GO:0098887,GO:0098978,GO:0099152" "GTPase activator activity|protein binding|phospholipid binding|intracellular anatomical structure|cytosol|exocytosis|signal transduction|postsynaptic density|dendrite|leading edge membrane|regulation of actin cytoskeleton organization|regulation of Rac protein signal transduction|negative regulation of Rac protein signal transduction|regulation of GTPase activity|dendritic spine|positive regulation of GTPase activity|presynaptic active zone|regulation of small GTPase mediated signal transduction|negative regulation of filopodium assembly|recycling endosome|regulation of dendritic spine morphogenesis|modification of dendritic spine|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane" ARHGAP45 975.0750245 1021.045704 929.1043448 0.909953728 -0.13613491 0.702191987 1 9.385183826 8.90795515 23526 Rho GTPase activating protein 45 "GO:0005096,GO:0005515,GO:0005576,GO:0005829,GO:0016020,GO:0032587,GO:0034774,GO:0035556,GO:0035578,GO:0043312,GO:0046872,GO:0051056,GO:0090630" GTPase activator activity|protein binding|extracellular region|cytosol|membrane|ruffle membrane|secretory granule lumen|intracellular signal transduction|azurophil granule lumen|neutrophil degranulation|metal ion binding|regulation of small GTPase mediated signal transduction|activation of GTPase activity ARHGAP5 2488.521094 2609.451795 2367.590393 0.907313328 -0.140327243 0.660643757 1 9.594158099 9.079879629 394 Rho GTPase activating protein 5 "GO:0003924,GO:0005096,GO:0005515,GO:0005525,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0007155,GO:0007266,GO:0030879,GO:0042169,GO:0043547,GO:0051056" GTPase activity|GTPase activator activity|protein binding|GTP binding|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|cell adhesion|Rho protein signal transduction|mammary gland development|SH2 domain binding|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction "hsa04510,hsa04670" Focal adhesion|Leukocyte transendothelial migration ARHGAP6 219.8339689 176.6023385 263.0655992 1.489592955 0.574918155 0.272017116 1 1.376679303 2.139027276 395 Rho GTPase activating protein 6 "GO:0005096,GO:0005737,GO:0005829,GO:0005884,GO:0007202,GO:0007266,GO:0015629,GO:0016004,GO:0017124,GO:0030041,GO:0043274,GO:0043547,GO:0048041,GO:0051056,GO:0051497,GO:0051895" GTPase activator activity|cytoplasm|cytosol|actin filament|activation of phospholipase C activity|Rho protein signal transduction|actin cytoskeleton|phospholipase activator activity|SH3 domain binding|actin filament polymerization|phospholipase binding|positive regulation of GTPase activity|focal adhesion assembly|regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly ARHGDIA 5790.025624 5329.53379 6250.517459 1.172807548 0.229966294 0.477482501 1 122.6361131 150.0241102 396 Rho GDP dissociation inhibitor alpha "GO:0005094,GO:0005096,GO:0005515,GO:0005829,GO:0005856,GO:0007162,GO:0007266,GO:0016020,GO:0035023,GO:0043066,GO:0043547,GO:0050771,GO:0050772,GO:0051056,GO:0070062,GO:0071526,GO:2000249" Rho GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|cytosol|cytoskeleton|negative regulation of cell adhesion|Rho protein signal transduction|membrane|regulation of Rho protein signal transduction|negative regulation of apoptotic process|positive regulation of GTPase activity|negative regulation of axonogenesis|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|extracellular exosome|semaphorin-plexin signaling pathway|regulation of actin cytoskeleton reorganization "hsa04722,hsa04962" Neurotrophin signaling pathway|Vasopressin-regulated water reabsorption ARHGDIB 281.7638503 267.9483757 295.579325 1.103120421 0.14159029 0.774635426 1 7.936046761 9.131519949 397 Rho GDP dissociation inhibitor beta "GO:0003924,GO:0005094,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0007162,GO:0007266,GO:0007275,GO:0016020,GO:0031267,GO:0031410,GO:0035023,GO:0043547,GO:0051056,GO:0070062,GO:0071461,GO:1901164,GO:2000249" GTPase activity|Rho GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|cytoskeleton|negative regulation of cell adhesion|Rho protein signal transduction|multicellular organism development|membrane|small GTPase binding|cytoplasmic vesicle|regulation of Rho protein signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|extracellular exosome|cellular response to redox state|negative regulation of trophoblast cell migration|regulation of actin cytoskeleton reorganization "hsa04722,hsa04962" Neurotrophin signaling pathway|Vasopressin-regulated water reabsorption ARHGEF1 1327.803645 1156.034848 1499.572442 1.297168891 0.375366331 0.265432787 1 17.85033134 24.15231346 9138 Rho guanine nucleotide exchange factor 1 "GO:0001664,GO:0003723,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0007266,GO:0043065,GO:0043547,GO:0051056" G protein-coupled receptor binding|RNA binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|Rho protein signal transduction|positive regulation of apoptotic process|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction "hsa04270,hsa04611,hsa04810,hsa04928,hsa05130,hsa05135,hsa05163,hsa05200,hsa05205" "Vascular smooth muscle contraction|Platelet activation|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Pathogenic Escherichia coli infection|Yersinia infection|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer" ARHGEF10 1233.042833 1110.361829 1355.723837 1.220974822 0.288033451 0.398075941 1 9.440307124 12.0228869 9639 Rho guanine nucleotide exchange factor 10 "GO:0005085,GO:0005515,GO:0005813,GO:0005829,GO:0019894,GO:0022011,GO:0030036,GO:0035023,GO:0051298,GO:0051496,GO:0090307,GO:0090630" guanyl-nucleotide exchange factor activity|protein binding|centrosome|cytosol|kinesin binding|myelination in peripheral nervous system|actin cytoskeleton organization|regulation of Rho protein signal transduction|centrosome duplication|positive regulation of stress fiber assembly|mitotic spindle assembly|activation of GTPase activity ARHGEF10L 276.6027174 218.2155332 334.9899016 1.535133163 0.618363805 0.202957524 1 1.243597045 1.991322793 55160 Rho guanine nucleotide exchange factor 10 like "GO:0005096,GO:0005829,GO:0030036,GO:0032933,GO:0043547,GO:0051496" GTPase activator activity|cytosol|actin cytoskeleton organization|SREBP signaling pathway|positive regulation of GTPase activity|positive regulation of stress fiber assembly ARHGEF11 1603.840739 1537.658292 1670.023186 1.086082125 0.119133198 0.718303318 1 9.375989401 10.62174091 9826 Rho guanine nucleotide exchange factor 11 "GO:0001558,GO:0001664,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0006941,GO:0007186,GO:0007266,GO:0016020,GO:0030010,GO:0030036,GO:0043065,GO:0043547,GO:0045893,GO:0051056" "regulation of cell growth|G protein-coupled receptor binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|striated muscle contraction|G protein-coupled receptor signaling pathway|Rho protein signal transduction|membrane|establishment of cell polarity|actin cytoskeleton organization|positive regulation of apoptotic process|positive regulation of GTPase activity|positive regulation of transcription, DNA-templated|regulation of small GTPase mediated signal transduction" "hsa04270,hsa04928,hsa05130,hsa05163,hsa05200" "Vascular smooth muscle contraction|Parathyroid hormone synthesis, secretion and action|Pathogenic Escherichia coli infection|Human cytomegalovirus infection|Pathways in cancer" ARHGEF12 4369.279033 4353.146148 4385.411918 1.007412058 0.010653904 0.974174885 1 19.61490173 20.6114816 23365 Rho guanine nucleotide exchange factor 12 "GO:0001664,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007186,GO:0007266,GO:0016020,GO:0043065,GO:0043547,GO:0051056,GO:0070062" G protein-coupled receptor binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|G protein-coupled receptor signaling pathway|Rho protein signal transduction|membrane|positive regulation of apoptotic process|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|extracellular exosome "hsa04270,hsa04360,hsa04611,hsa04625,hsa04810,hsa05130,hsa05135,hsa05152,hsa05163,hsa05200,hsa05205" Vascular smooth muscle contraction|Axon guidance|Platelet activation|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Yersinia infection|Tuberculosis|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer ARHGEF16 30.10722621 37.55337083 22.66108158 0.603436684 -0.728725691 0.468564082 1 0.489057792 0.307827787 27237 Rho guanine nucleotide exchange factor 16 "GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0030165,GO:0030971,GO:0031267,GO:0043065,GO:0045296,GO:0051056,GO:0060326,GO:0090630,GO:1903078" guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|PDZ domain binding|receptor tyrosine kinase binding|small GTPase binding|positive regulation of apoptotic process|cadherin binding|regulation of small GTPase mediated signal transduction|cell chemotaxis|activation of GTPase activity|positive regulation of protein localization to plasma membrane ARHGEF17 1816.812992 1649.303449 1984.322535 1.203127621 0.266789684 0.411557761 1 7.998027698 10.03715269 9828 Rho guanine nucleotide exchange factor 17 "GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0030036,GO:0043065,GO:0050790,GO:0051056" guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|actin cytoskeleton organization|positive regulation of apoptotic process|regulation of catalytic activity|regulation of small GTPase mediated signal transduction ARHGEF18 1110.417991 978.4175535 1242.418429 1.269824345 0.344628943 0.319794047 1 5.895704632 7.808997732 23370 Rho/Rac guanine nucleotide exchange factor 18 "GO:0005085,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0007179,GO:0007186,GO:0007264,GO:0008360,GO:0016324,GO:0030036,GO:0030054,GO:0035023,GO:0043065,GO:0045177,GO:0046872,GO:0050790,GO:0051056,GO:0051497,GO:0070062,GO:0150105" guanyl-nucleotide exchange factor activity|protein binding|cytosol|cytoskeleton|plasma membrane|transforming growth factor beta receptor signaling pathway|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|regulation of cell shape|apical plasma membrane|actin cytoskeleton organization|cell junction|regulation of Rho protein signal transduction|positive regulation of apoptotic process|apical part of cell|metal ion binding|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|extracellular exosome|protein localization to cell-cell junction hsa04530 Tight junction ARHGEF19 460.6769327 476.0143492 445.3395163 0.935559016 -0.096099431 0.822175247 1 7.000129938 6.831140533 128272 Rho guanine nucleotide exchange factor 19 "GO:0005096,GO:0005515,GO:0005829,GO:0007186,GO:0032956,GO:0042060,GO:0043065,GO:0051056,GO:0060071,GO:0090630" "GTPase activator activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|regulation of actin cytoskeleton organization|wound healing|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction|Wnt signaling pathway, planar cell polarity pathway|activation of GTPase activity" ARHGEF2 1800.033805 1647.273537 1952.794074 1.185470433 0.245459681 0.450397279 1 11.74058449 14.51765177 9181 Rho/Rac guanine nucleotide exchange factor 2 "GO:0000902,GO:0005085,GO:0005515,GO:0005737,GO:0005794,GO:0005819,GO:0005829,GO:0005856,GO:0005874,GO:0005923,GO:0005925,GO:0006886,GO:0007015,GO:0007026,GO:0007049,GO:0007186,GO:0008017,GO:0008134,GO:0008270,GO:0031267,GO:0031410,GO:0031982,GO:0032587,GO:0032755,GO:0032760,GO:0032991,GO:0035023,GO:0035556,GO:0042127,GO:0043065,GO:0045087,GO:0045666,GO:0045944,GO:0050731,GO:0050790,GO:0051056,GO:0051092,GO:0055059,GO:0060546,GO:0071225,GO:0071356,GO:0071474,GO:1902042,GO:1902219,GO:2001224" cell morphogenesis|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|Golgi apparatus|spindle|cytosol|cytoskeleton|microtubule|bicellular tight junction|focal adhesion|intracellular protein transport|actin filament organization|negative regulation of microtubule depolymerization|cell cycle|G protein-coupled receptor signaling pathway|microtubule binding|transcription factor binding|zinc ion binding|small GTPase binding|cytoplasmic vesicle|vesicle|ruffle membrane|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|protein-containing complex|regulation of Rho protein signal transduction|intracellular signal transduction|regulation of cell population proliferation|positive regulation of apoptotic process|innate immune response|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of peptidyl-tyrosine phosphorylation|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|positive regulation of NF-kappaB transcription factor activity|asymmetric neuroblast division|negative regulation of necroptotic process|cellular response to muramyl dipeptide|cellular response to tumor necrosis factor|cellular hyperosmotic response|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|positive regulation of neuron migration "hsa04530,hsa05130,hsa05131,hsa05418" Tight junction|Pathogenic Escherichia coli infection|Shigellosis|Fluid shear stress and atherosclerosis ARHGEF25 799.9357368 666.8260712 933.0454025 1.399233537 0.484636774 0.18731229 1 11.77148417 17.1805617 115557 Rho guanine nucleotide exchange factor 25 "GO:0005085,GO:0005829,GO:0005886,GO:0007186,GO:0030016,GO:0030017,GO:0035023,GO:0050790" guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|myofibril|sarcomere|regulation of Rho protein signal transduction|regulation of catalytic activity ARHGEF26 94.4436072 91.34603715 97.54117724 1.067820568 0.094669242 0.906135967 1 1.238649139 1.37962964 26084 Rho guanine nucleotide exchange factor 26 "GO:0001726,GO:0001886,GO:0005829,GO:0007186,GO:0043065,GO:0051056,GO:0090630,GO:0097178" ruffle|endothelial cell morphogenesis|cytosol|G protein-coupled receptor signaling pathway|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction|activation of GTPase activity|ruffle assembly "hsa05100,hsa05132" Bacterial invasion of epithelial cells|Salmonella infection ARHGEF28 1925.999193 1637.123977 2214.874408 1.35290573 0.436061316 0.177473685 1 9.665954069 13.64043414 64283 Rho guanine nucleotide exchange factor 28 "GO:0000902,GO:0003723,GO:0005085,GO:0005829,GO:0005886,GO:0030154,GO:0035023,GO:0035556,GO:0046872,GO:0048013,GO:0050790" cell morphogenesis|RNA binding|guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|cell differentiation|regulation of Rho protein signal transduction|intracellular signal transduction|metal ion binding|ephrin receptor signaling pathway|regulation of catalytic activity hsa05135 Yersinia infection ARHGEF3 200.5146707 202.9911937 198.0381477 0.9755997 -0.03563878 0.957218243 1 1.689529638 1.719306887 50650 Rho guanine nucleotide exchange factor 3 "GO:0005515,GO:0005829,GO:0007186,GO:0007266,GO:0035025,GO:0043065,GO:0050790,GO:0051056" protein binding|cytosol|G protein-coupled receptor signaling pathway|Rho protein signal transduction|positive regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of catalytic activity|regulation of small GTPase mediated signal transduction ARHGEF35 99.96920352 64.95718198 134.9812251 2.078003093 1.055197802 0.121215472 1 1.239115673 2.685801856 445328 Rho guanine nucleotide exchange factor 35 ARHGEF37 164.6240268 241.5595205 87.68853307 0.363010048 -1.461918614 0.012148885 0.486935126 2.307892387 0.87387664 389337 Rho guanine nucleotide exchange factor 37 "GO:0005737,GO:0050790" cytoplasm|regulation of catalytic activity ARHGEF39 434.0829583 375.5337083 492.6322083 1.311818879 0.391568543 0.356289826 1 5.001172107 6.843237406 84904 Rho guanine nucleotide exchange factor 39 "GO:0005085,GO:0005515,GO:0005886,GO:0030335,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|plasma membrane|positive regulation of cell migration|regulation of catalytic activity ARHGEF4 208.4183128 305.5017465 111.3348791 0.364432873 -1.456274996 0.006999428 0.341973728 1.178414754 0.447952171 50649 Rho guanine nucleotide exchange factor 4 "GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0019904,GO:0030032,GO:0032587,GO:0035556,GO:0043065,GO:0046847,GO:0050790,GO:0051056" guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|protein domain specific binding|lamellipodium assembly|ruffle membrane|intracellular signal transduction|positive regulation of apoptotic process|filopodium assembly|regulation of catalytic activity|regulation of small GTPase mediated signal transduction hsa04810 Regulation of actin cytoskeleton ARHGEF40 1809.862201 1578.256531 2041.467871 1.293495595 0.371275141 0.253248584 1 11.33803199 15.29743308 55701 Rho guanine nucleotide exchange factor 40 "GO:0005085,GO:0005829,GO:0005886,GO:0050790" guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|regulation of catalytic activity ARHGEF5 356.1810053 269.9782876 442.383723 1.638590003 0.712454918 0.112764674 1 2.491517464 4.258436408 7984 Rho guanine nucleotide exchange factor 5 "GO:0002102,GO:0005085,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0008289,GO:0030054,GO:0032956,GO:0035556,GO:0042995,GO:0043065,GO:0043087,GO:0043507,GO:0051056,GO:0051091,GO:0051493,GO:0051496,GO:0070372,GO:0071944,GO:0090630,GO:1904591" podosome|guanyl-nucleotide exchange factor activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|lipid binding|cell junction|regulation of actin cytoskeleton organization|intracellular signal transduction|cell projection|positive regulation of apoptotic process|regulation of GTPase activity|positive regulation of JUN kinase activity|regulation of small GTPase mediated signal transduction|positive regulation of DNA-binding transcription factor activity|regulation of cytoskeleton organization|positive regulation of stress fiber assembly|regulation of ERK1 and ERK2 cascade|cell periphery|activation of GTPase activity|positive regulation of protein import ARHGEF6 41.48230432 40.59823873 42.36636991 1.043551918 0.061502379 0.975157921 1 0.344357322 0.374834289 9459 Rac/Cdc42 guanine nucleotide exchange factor 6 "GO:0005085,GO:0005096,GO:0005515,GO:0005829,GO:0006915,GO:0007186,GO:0007254,GO:0030027,GO:0030032,GO:0043065,GO:0043547,GO:0051056" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytosol|apoptotic process|G protein-coupled receptor signaling pathway|JNK cascade|lamellipodium|lamellipodium assembly|positive regulation of apoptotic process|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction "hsa04810,hsa05212" Regulation of actin cytoskeleton|Pancreatic cancer ARHGEF7 1077.549205 1122.541301 1032.557109 0.919838858 -0.12054695 0.730697838 1 5.498864185 5.27595005 8874 Rho guanine nucleotide exchange factor 7 "GO:0001726,GO:0005085,GO:0005515,GO:0005829,GO:0005925,GO:0005938,GO:0007030,GO:0007165,GO:0007186,GO:0007399,GO:0010763,GO:0019901,GO:0030027,GO:0030032,GO:0032991,GO:0035556,GO:0042059,GO:0043005,GO:0043025,GO:0043065,GO:0043547,GO:0048013,GO:0048041,GO:0051056,GO:1900026,GO:1904424,GO:2000394" ruffle|guanyl-nucleotide exchange factor activity|protein binding|cytosol|focal adhesion|cell cortex|Golgi organization|signal transduction|G protein-coupled receptor signaling pathway|nervous system development|positive regulation of fibroblast migration|protein kinase binding|lamellipodium|lamellipodium assembly|protein-containing complex|intracellular signal transduction|negative regulation of epidermal growth factor receptor signaling pathway|neuron projection|neuronal cell body|positive regulation of apoptotic process|positive regulation of GTPase activity|ephrin receptor signaling pathway|focal adhesion assembly|regulation of small GTPase mediated signal transduction|positive regulation of substrate adhesion-dependent cell spreading|regulation of GTP binding|positive regulation of lamellipodium morphogenesis "hsa04810,hsa05135" Regulation of actin cytoskeleton|Yersinia infection ARHGEF9 494.763073 415.1169911 574.4091548 1.383728364 0.468560759 0.253029154 1 1.535174235 2.215768816 23229 Cdc42 guanine nucleotide exchange factor 9 "GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0014069,GO:0043065,GO:0050790,GO:0051056" guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|postsynaptic density|positive regulation of apoptotic process|regulation of catalytic activity|regulation of small GTPase mediated signal transduction ARID1A 2512.873356 2556.674084 2469.072628 0.965736166 -0.050298989 0.875817041 1 15.06533135 15.17585308 8289 AT-rich interaction domain 1A "GO:0000785,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0016514,GO:0016922,GO:0030520,GO:0030521,GO:0031491,GO:0035060,GO:0042766,GO:0042921,GO:0043044,GO:0045893,GO:0048096,GO:0071564,GO:0071565" "chromatin|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|SWI/SNF complex|nuclear receptor binding|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|nucleosome binding|brahma complex|nucleosome mobilization|glucocorticoid receptor signaling pathway|ATP-dependent chromatin remodeling|positive regulation of transcription, DNA-templated|chromatin-mediated maintenance of transcription|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor ARID1B 1438.562014 1453.416947 1423.707082 0.979558609 -0.029796281 0.930885979 1 8.643781236 8.831818231 57492 AT-rich interaction domain 1B "GO:0002931,GO:0003677,GO:0003713,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0007399,GO:0016514,GO:0031491,GO:0035060,GO:0043044,GO:0045893,GO:0048096,GO:0071565,GO:1904385" "response to ischemia|DNA binding|transcription coactivator activity|protein binding|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|nervous system development|SWI/SNF complex|nucleosome binding|brahma complex|ATP-dependent chromatin remodeling|positive regulation of transcription, DNA-templated|chromatin-mediated maintenance of transcription|nBAF complex|cellular response to angiotensin" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma ARID ARID2 1421.272628 1483.865626 1358.67963 0.915635221 -0.127155136 0.704465153 1 8.600659096 8.214292315 196528 AT-rich interaction domain 2 "GO:0003007,GO:0003677,GO:0005515,GO:0005654,GO:0005886,GO:0006337,GO:0006355,GO:0008285,GO:0030336,GO:0042592,GO:0046872,GO:0048568,GO:0060038,GO:0060982,GO:1905168" "heart morphogenesis|DNA binding|protein binding|nucleoplasm|plasma membrane|nucleosome disassembly|regulation of transcription, DNA-templated|negative regulation of cell population proliferation|negative regulation of cell migration|homeostatic process|metal ion binding|embryonic organ development|cardiac muscle cell proliferation|coronary artery morphogenesis|positive regulation of double-strand break repair via homologous recombination" hsa05225 Hepatocellular carcinoma RFX ARID3A 512.9526083 513.56772 512.3374966 0.997604555 -0.003460043 0.998716957 1 3.543650308 3.687442115 1820 AT-rich interaction domain 3A "GO:0003677,GO:0003682,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006977,GO:0042802,GO:0045121,GO:0045944" "DNA binding|chromatin binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|identical protein binding|membrane raft|positive regulation of transcription by RNA polymerase II" ARID ARID3B 357.0150904 293.3222749 420.7079059 1.434285569 0.520332296 0.246091762 1 3.511164841 5.25294408 10620 AT-rich interaction domain 3B "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008150,GO:0045944" DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|biological_process|positive regulation of transcription by RNA polymerase II ARID3C 3.970749218 2.029911937 5.911586499 2.912237912 1.542128219 0.515744462 1 0.021716916 0.065969156 138715 AT-rich interaction domain 3C "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0045121,GO:0045944" DNA binding|chromatin binding|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|membrane raft|positive regulation of transcription by RNA polymerase II ARID4A 577.4401687 544.016399 610.8639383 1.122877802 0.167200934 0.674119641 1 3.610129905 4.228353184 5926 AT-rich interaction domain 4A "GO:0000976,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006349,GO:0006357,GO:0007283,GO:0017053,GO:0034773,GO:0036124,GO:0045892,GO:0045944,GO:0048821,GO:0080182,GO:0097368" "transcription regulatory region sequence-specific DNA binding|DNA binding|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of gene expression by genetic imprinting|regulation of transcription by RNA polymerase II|spermatogenesis|transcription repressor complex|histone H4-K20 trimethylation|histone H3-K9 trimethylation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|erythrocyte development|histone H3-K4 trimethylation|establishment of Sertoli cell barrier" ARID4B 908.6641942 960.1483461 857.1800424 0.892757922 -0.163659064 0.649492295 1 7.046533333 6.561832695 51742 AT-rich interaction domain 4B "GO:0000976,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006325,GO:0006357,GO:0008150" transcription regulatory region sequence-specific DNA binding|molecular_function|protein binding|cellular_component|nucleus|nucleoplasm|mitochondrion|cytosol|chromatin organization|regulation of transcription by RNA polymerase II|biological_process ARID5A 114.9357217 145.1387035 84.73273982 0.583805269 -0.776440863 0.231061678 1 1.542333888 0.939209207 10865 AT-rich interaction domain 5A "GO:0000122,GO:0000976,GO:0003677,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0008134,GO:0030331,GO:0042802,GO:0043565,GO:0045087,GO:0045892,GO:0046965,GO:0046966,GO:0050681,GO:0071391" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|DNA binding|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|transcription factor binding|estrogen receptor binding|identical protein binding|sequence-specific DNA binding|innate immune response|negative regulation of transcription, DNA-templated|retinoid X receptor binding|thyroid hormone receptor binding|androgen receptor binding|cellular response to estrogen stimulus" ARID5B 257.5870157 366.3991046 148.7749269 0.406046098 -1.300284569 0.009613292 0.413488604 1.840589374 0.77955755 84159 AT-rich interaction domain 5B "GO:0000122,GO:0000976,GO:0001822,GO:0001889,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006807,GO:0008584,GO:0008585,GO:0009791,GO:0010761,GO:0030325,GO:0035264,GO:0045444,GO:0045892,GO:0045893,GO:0048008,GO:0048468,GO:0048644,GO:0048705,GO:0051091,GO:0060021,GO:0060325,GO:0060612,GO:0060613,GO:1990830" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|kidney development|liver development|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nitrogen compound metabolic process|male gonad development|female gonad development|post-embryonic development|fibroblast migration|adrenal gland development|multicellular organism growth|fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|platelet-derived growth factor receptor signaling pathway|cell development|muscle organ morphogenesis|skeletal system morphogenesis|positive regulation of DNA-binding transcription factor activity|roof of mouth development|face morphogenesis|adipose tissue development|fat pad development|cellular response to leukemia inhibitory factor" ARIH1 2744.944942 2593.212499 2896.677385 1.117022761 0.159658583 0.616546058 1 6.058262133 7.058720942 25820 ariadne RBR E3 ubiquitin protein ligase 1 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006511,GO:0008270,GO:0015030,GO:0016567,GO:0016604,GO:0018215,GO:0019005,GO:0019787,GO:0031462,GO:0031463,GO:0031464,GO:0031624,GO:0031625,GO:0032436,GO:0061630,GO:0097413" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|Cajal body|protein ubiquitination|nuclear body|protein phosphopantetheinylation|SCF ubiquitin ligase complex|ubiquitin-like protein transferase activity|Cul2-RING ubiquitin ligase complex|Cul3-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity|Lewy body ARIH2 2441.089593 2296.845356 2585.333829 1.125602044 0.170696854 0.593271212 1 14.75483441 17.32348016 10425 ariadne RBR E3 ubiquitin protein ligase 2 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006511,GO:0007275,GO:0008270,GO:0016567,GO:0031466,GO:0031624,GO:0032436,GO:0048588,GO:0061630,GO:0070534,GO:0070936,GO:0071425,GO:1903955" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|ubiquitin-dependent protein catabolic process|multicellular organism development|zinc ion binding|protein ubiquitination|Cul5-RING ubiquitin ligase complex|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|developmental cell growth|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|hematopoietic stem cell proliferation|positive regulation of protein targeting to mitochondrion ARL1 1757.459594 1633.064153 1881.855036 1.152346056 0.204574031 0.530457005 1 25.48811656 30.63631978 400 ADP ribosylation factor like GTPase 1 "GO:0003924,GO:0005525,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0006886,GO:0007030,GO:0008047,GO:0009404,GO:0016192,GO:0019904,GO:0031584,GO:0032588,GO:0034067,GO:0042147,GO:0046872" "GTPase activity|GTP binding|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|intracellular protein transport|Golgi organization|enzyme activator activity|toxin metabolic process|vesicle-mediated transport|protein domain specific binding|activation of phospholipase D activity|trans-Golgi network membrane|protein localization to Golgi apparatus|retrograde transport, endosome to Golgi|metal ion binding" ARL10 350.3651744 377.5636202 323.1667286 0.855926555 -0.224441088 0.621543964 1 1.623420104 1.449383623 285598 ADP ribosylation factor like GTPase 10 GO:0005525 GTP binding ARL13B 606.2233992 524.7322356 687.7145627 1.310600943 0.390228475 0.317396856 1 6.226765837 8.512339566 200894 ADP ribosylation factor like GTPase 13B "GO:0005515,GO:0005525,GO:0005929,GO:0007224,GO:0021532,GO:0021830,GO:0021943,GO:0031514,GO:0060170,GO:0060271,GO:0097500,GO:0097730,GO:1905515" protein binding|GTP binding|cilium|smoothened signaling pathway|neural tube patterning|interneuron migration from the subpallium to the cortex|formation of radial glial scaffolds|motile cilium|ciliary membrane|cilium assembly|receptor localization to non-motile cilium|non-motile cilium|non-motile cilium assembly ARL14EP 380.2672814 367.4140606 393.1205022 1.069965863 0.097564768 0.829594002 1 6.13323204 6.845028286 120534 ADP ribosylation factor like GTPase 14 effector protein "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0005925,GO:0043231" protein binding|nucleoplasm|nucleolus|cytosol|plasma membrane|focal adhesion|intracellular membrane-bounded organelle ARL14EPL 6.941388244 3.044867905 10.83790858 3.559401892 1.831634837 0.281983226 1 0.092731099 0.344285208 644100 ADP ribosylation factor like GTPase 14 effector protein like ARL15 224.2028324 239.5296085 208.8760563 0.872026041 -0.197556876 0.709041955 1 3.376378977 3.071118482 54622 ADP ribosylation factor like GTPase 15 "GO:0003674,GO:0005515,GO:0005525,GO:0008150,GO:0070062" molecular_function|protein binding|GTP binding|biological_process|extracellular exosome ARL16 468.0839832 443.5357582 492.6322083 1.11069333 0.151460534 0.718797611 1 18.95655819 21.96188342 339231 ADP ribosylation factor like GTPase 16 "GO:0005515,GO:0005525" protein binding|GTP binding ARL17A 97.60724131 105.5554207 89.65906191 0.849402724 -0.235479359 0.740606093 1 0.569330105 0.504421661 51326 ADP ribosylation factor like GTPase 17A ARL17B 105.3112073 93.37594909 117.2464656 1.25563881 0.328421526 0.629106775 1 0.511703355 0.670191515 100506084 ADP ribosylation factor like GTPase 17B "GO:0005525,GO:0005737,GO:0005794,GO:0005886,GO:0006886,GO:0016192" GTP binding|cytoplasm|Golgi apparatus|plasma membrane|intracellular protein transport|vesicle-mediated transport ARL2 2016.296377 2051.226012 1981.366742 0.965942675 -0.049990521 0.878033484 1 111.4671258 112.3088774 402 ADP ribosylation factor like GTPase 2 "GO:0003924,GO:0005095,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005758,GO:0005759,GO:0005794,GO:0005813,GO:0005829,GO:0005925,GO:0005929,GO:0007021,GO:0007098,GO:0010811,GO:0015630,GO:0016328,GO:0019003,GO:0031113,GO:0031116,GO:0034260,GO:0050796,GO:0051457,GO:0070830" GTPase activity|GTPase inhibitor activity|protein binding|GTP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrial intermembrane space|mitochondrial matrix|Golgi apparatus|centrosome|cytosol|focal adhesion|cilium|tubulin complex assembly|centrosome cycle|positive regulation of cell-substrate adhesion|microtubule cytoskeleton|lateral plasma membrane|GDP binding|regulation of microtubule polymerization|positive regulation of microtubule polymerization|negative regulation of GTPase activity|regulation of insulin secretion|maintenance of protein location in nucleus|bicellular tight junction assembly ARL2BP 728.8982216 592.7342855 865.0621577 1.459443428 0.545418289 0.145524668 1 15.24626741 23.2095504 23568 ADP ribosylation factor like GTPase 2 binding protein "GO:0003713,GO:0005515,GO:0005634,GO:0005758,GO:0005759,GO:0005813,GO:0005819,GO:0005829,GO:0005929,GO:0007165,GO:0030496,GO:0030695,GO:0042531,GO:0045893,GO:0050790,GO:0050796,GO:0051457" "transcription coactivator activity|protein binding|nucleus|mitochondrial intermembrane space|mitochondrial matrix|centrosome|spindle|cytosol|cilium|signal transduction|midbody|GTPase regulator activity|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of transcription, DNA-templated|regulation of catalytic activity|regulation of insulin secretion|maintenance of protein location in nucleus" ARL3 1288.040729 1266.665049 1309.41641 1.033751118 0.047888889 0.889626683 1 15.34372547 16.54484646 403 ADP ribosylation factor like GTPase 3 "GO:0000139,GO:0000281,GO:0000287,GO:0001822,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005876,GO:0005881,GO:0005929,GO:0006892,GO:0006893,GO:0007224,GO:0007264,GO:0008017,GO:0015630,GO:0019003,GO:0030496,GO:0032391,GO:0032794,GO:0042073,GO:0042461,GO:0060271,GO:0061512,GO:0070062,GO:1903441" Golgi membrane|mitotic cytokinesis|magnesium ion binding|kidney development|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|spindle microtubule|cytoplasmic microtubule|cilium|post-Golgi vesicle-mediated transport|Golgi to plasma membrane transport|smoothened signaling pathway|small GTPase mediated signal transduction|microtubule binding|microtubule cytoskeleton|GDP binding|midbody|photoreceptor connecting cilium|GTPase activating protein binding|intraciliary transport|photoreceptor cell development|cilium assembly|protein localization to cilium|extracellular exosome|protein localization to ciliary membrane ARL4A 210.2782402 196.9014579 223.6550226 1.135872862 0.183801364 0.734979918 1 3.291209312 3.899430251 10124 ADP ribosylation factor like GTPase 4A "GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006886,GO:0016192,GO:0050873" protein binding|GTP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|intracellular protein transport|vesicle-mediated transport|brown fat cell differentiation ARL4C 3856.753739 4643.423555 3070.083922 0.661168185 -0.596910791 0.061529029 1 58.19673894 40.13530119 10123 ADP ribosylation factor like GTPase 4C "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006886,GO:0016192,GO:0030175,GO:0032456,GO:0043014" GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|plasma membrane|intracellular protein transport|vesicle-mediated transport|filopodium|endocytic recycling|alpha-tubulin binding ARL4D 159.869173 152.2433953 167.4949508 1.100178767 0.137737964 0.821313986 1 4.777317774 5.482306586 379 ADP ribosylation factor like GTPase 4D "GO:0003924,GO:0005515,GO:0005525,GO:0005730,GO:0005737,GO:0005886,GO:0006886,GO:0009306,GO:0016192" GTPase activity|protein binding|GTP binding|nucleolus|cytoplasm|plasma membrane|intracellular protein transport|protein secretion|vesicle-mediated transport ARL5A 578.2472838 531.8369274 624.6576401 1.174528522 0.232081747 0.557767058 1 5.116957478 6.268899466 26225 ADP ribosylation factor like GTPase 5A "GO:0005525,GO:0005737,GO:0005802,GO:0006886,GO:0016192,GO:1903292" GTP binding|cytoplasm|trans-Golgi network|intracellular protein transport|vesicle-mediated transport|protein localization to Golgi membrane ARL5B 848.4591444 953.0436543 743.8746345 0.780525248 -0.357482795 0.325129531 1 6.495532089 5.288318678 221079 ADP ribosylation factor like GTPase 5B "GO:0005515,GO:0005525,GO:0005737,GO:0005802,GO:0006886,GO:0016192,GO:1903292" protein binding|GTP binding|cytoplasm|trans-Golgi network|intracellular protein transport|vesicle-mediated transport|protein localization to Golgi membrane ARL6 202.1261793 212.1257974 192.1265612 0.905719925 -0.1428631 0.797532258 1 1.695616052 1.601907264 84100 ADP ribosylation factor like GTPase 6 "GO:0003924,GO:0005515,GO:0005525,GO:0005543,GO:0005737,GO:0005879,GO:0005886,GO:0005929,GO:0005930,GO:0006612,GO:0006886,GO:0007368,GO:0007601,GO:0016020,GO:0016055,GO:0016192,GO:0030117,GO:0032402,GO:0046872,GO:0051258,GO:0060271,GO:0061512,GO:0070062" GTPase activity|protein binding|GTP binding|phospholipid binding|cytoplasm|axonemal microtubule|plasma membrane|cilium|axoneme|protein targeting to membrane|intracellular protein transport|determination of left/right symmetry|visual perception|membrane|Wnt signaling pathway|vesicle-mediated transport|membrane coat|melanosome transport|metal ion binding|protein polymerization|cilium assembly|protein localization to cilium|extracellular exosome ARL6IP1 3437.860969 2881.459994 3994.261945 1.386193788 0.471128958 0.13903452 1 59.51704059 86.05601006 23204 ADP ribosylation factor like GTPase 6 interacting protein 1 "GO:0002038,GO:0005515,GO:0005784,GO:0005789,GO:0006613,GO:0006915,GO:0016020,GO:0016021,GO:0030176,GO:0042802,GO:0043066,GO:0043154,GO:0071787,GO:1903371,GO:1990809" positive regulation of L-glutamate import across plasma membrane|protein binding|Sec61 translocon complex|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|apoptotic process|membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|identical protein binding|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|endoplasmic reticulum tubular network formation|regulation of endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network membrane organization ARL6IP4 2501.320129 2541.449745 2461.190513 0.968419902 -0.046295367 0.885761165 1 107.8922581 108.9858005 51329 ADP ribosylation factor like GTPase 6 interacting protein 4 "GO:0003723,GO:0005515,GO:0005634,GO:0005730,GO:0006397,GO:0008380,GO:0016607" RNA binding|protein binding|nucleus|nucleolus|mRNA processing|RNA splicing|nuclear speck ARL6IP5 1764.716703 1792.41224 1737.021166 0.969096912 -0.04528715 0.89100894 1 42.53952986 43.00072967 10550 ADP ribosylation factor like GTPase 6 interacting protein 5 "GO:0002037,GO:0003674,GO:0005515,GO:0005789,GO:0005856,GO:0005886,GO:0006749,GO:0007611,GO:0008631,GO:0010917,GO:0015813,GO:0016020,GO:0016021,GO:0032874,GO:0036475,GO:0043065,GO:0043280,GO:0051051,GO:0072659,GO:0098712" negative regulation of L-glutamate import across plasma membrane|molecular_function|protein binding|endoplasmic reticulum membrane|cytoskeleton|plasma membrane|glutathione metabolic process|learning or memory|intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of mitochondrial membrane potential|L-glutamate transmembrane transport|membrane|integral component of membrane|positive regulation of stress-activated MAPK cascade|neuron death in response to oxidative stress|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transport|protein localization to plasma membrane|L-glutamate import across plasma membrane ARL6IP6 725.5158602 698.2897062 752.7420142 1.077979537 0.108329792 0.775270356 1 9.550610371 10.73884501 151188 ADP ribosylation factor like GTPase 6 interacting protein 6 "GO:0005515,GO:0005637,GO:0016021" protein binding|nuclear inner membrane|integral component of membrane ARL8A 852.1344619 732.7982092 971.4707147 1.325700176 0.406754528 0.262459281 1 20.74546905 28.68695831 127829 ADP ribosylation factor like GTPase 8A "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005765,GO:0005774,GO:0005886,GO:0007049,GO:0007059,GO:0008089,GO:0015031,GO:0016020,GO:0030496,GO:0031902,GO:0035577,GO:0043014,GO:0043312,GO:0045202,GO:0048487,GO:0051233,GO:0051301,GO:0070062,GO:0101003,GO:1904115" GTPase activity|protein binding|GTP binding|cytoplasm|lysosomal membrane|vacuolar membrane|plasma membrane|cell cycle|chromosome segregation|anterograde axonal transport|protein transport|membrane|midbody|late endosome membrane|azurophil granule membrane|alpha-tubulin binding|neutrophil degranulation|synapse|beta-tubulin binding|spindle midzone|cell division|extracellular exosome|ficolin-1-rich granule membrane|axon cytoplasm hsa05132 Salmonella infection ARL8B 2476.851822 2552.61426 2401.089383 0.940639336 -0.08828643 0.782906658 1 44.07804542 43.24753851 55207 ADP ribosylation factor like GTPase 8B "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005765,GO:0005774,GO:0007049,GO:0007059,GO:0008089,GO:0015031,GO:0016020,GO:0016197,GO:0019003,GO:0030496,GO:0031902,GO:0032418,GO:0043014,GO:0045202,GO:0048487,GO:0051233,GO:0051301,GO:0070062,GO:1904115" GTPase activity|protein binding|GTP binding|cytoplasm|lysosomal membrane|vacuolar membrane|cell cycle|chromosome segregation|anterograde axonal transport|protein transport|membrane|endosomal transport|GDP binding|midbody|late endosome membrane|lysosome localization|alpha-tubulin binding|synapse|beta-tubulin binding|spindle midzone|cell division|extracellular exosome|axon cytoplasm hsa05132 Salmonella infection ARMC1 1840.655054 1629.004329 2052.30578 1.25985287 0.333255261 0.304378567 1 26.613975 34.97401597 55156 armadillo repeat containing 1 "GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0030001,GO:0046872,GO:0048312" protein binding|mitochondrion|mitochondrial outer membrane|cytosol|metal ion transport|metal ion binding|intracellular distribution of mitochondria ARMC10 531.8750299 594.7641975 468.9858623 0.788524031 -0.342773372 0.394920863 1 6.877330685 5.656538796 83787 armadillo repeat containing 10 "GO:0005739,GO:0005783,GO:0005789,GO:0016021,GO:0040008,GO:1902254" mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|regulation of growth|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ARMC12 8.552896852 12.17947162 4.926322083 0.404477488 -1.305868687 0.399342453 1 0.20438942 0.086232047 221481 armadillo repeat containing 12 GO:0005634 nucleus ARMC2 44.21268933 58.86744617 29.5579325 0.502109985 -0.993924681 0.261274038 1 0.6331341 0.331596923 84071 armadillo repeat containing 2 "GO:0005515,GO:0007288,GO:0044782" protein binding|sperm axoneme assembly|cilium organization ARMC5 236.1150801 245.6193443 226.6108158 0.922609807 -0.116207468 0.82698518 1 2.855774403 2.74826048 79798 armadillo repeat containing 5 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005925" protein binding|nucleoplasm|cytoplasm|cytosol|focal adhesion hsa04934 Cushing syndrome ARMC6 550.3575214 578.524902 522.1901408 0.902623446 -0.147803841 0.71393444 1 11.09857779 10.4493643 93436 armadillo repeat containing 6 "GO:0002244,GO:0005829" hematopoietic progenitor cell differentiation|cytosol ARMC7 402.2818298 424.2515948 380.3120648 0.89643049 -0.157736376 0.71930328 1 7.66566058 7.167738206 79637 armadillo repeat containing 7 GO:0005515 protein binding ARMC8 435.1018736 512.552764 357.6509832 0.697783737 -0.519148121 0.220622626 1 4.780661017 3.479563154 25852 armadillo repeat containing 8 "GO:0000151,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0034657,GO:0035580,GO:0043161,GO:0043231,GO:0043312,GO:1904724" ubiquitin ligase complex|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|GID complex|specific granule lumen|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|neutrophil degranulation|tertiary granule lumen ARMC9 1330.496174 1272.754784 1388.237563 1.090734508 0.125299982 0.711224113 1 4.386264277 4.990335885 80210 armadillo repeat containing 9 "GO:0005737,GO:0005814,GO:0036064,GO:0045880,GO:0060271,GO:0070062,GO:0097542" cytoplasm|centriole|ciliary basal body|positive regulation of smoothened signaling pathway|cilium assembly|extracellular exosome|ciliary tip ARMCX1 3.463271234 1.014955968 5.911586499 5.824475823 2.542128219 0.321345721 1 0.024190089 0.146963756 51309 armadillo repeat containing X-linked 1 "GO:0005515,GO:0005739,GO:0005741,GO:0016021,GO:0061484" protein binding|mitochondrion|mitochondrial outer membrane|integral component of membrane|hematopoietic stem cell homeostasis ARMCX2 1354.884808 1323.502583 1386.267034 1.047422991 0.066844178 0.844169103 1 23.38009654 25.54373102 9823 armadillo repeat containing X-linked 2 "GO:0005739,GO:0005741,GO:0016021" mitochondrion|mitochondrial outer membrane|integral component of membrane ARMCX3 1389.784745 1351.92135 1427.64814 1.056014198 0.078629231 0.816033767 1 19.32544371 21.28703435 51566 armadillo repeat containing X-linked 3 "GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0007005,GO:0019896,GO:0031307,GO:0034613,GO:0045944,GO:1904115" protein binding|nucleus|mitochondrion|cytosol|mitochondrion organization|axonal transport of mitochondrion|integral component of mitochondrial outer membrane|cellular protein localization|positive regulation of transcription by RNA polymerase II|axon cytoplasm ARMCX4 139.5794562 179.6472064 99.51170607 0.553928492 -0.852228349 0.160888526 1 1.225551892 0.708110996 100131755 armadillo repeat containing X-linked 4 GO:0016021 integral component of membrane ARMCX5 241.3680092 267.9483757 214.7876428 0.801600839 -0.319044076 0.531885512 1 4.523546654 3.782275563 64860 armadillo repeat containing X-linked 5 GO:0005515 protein binding ARMCX5-GPRASP2 18.46492412 16.23929549 20.69055275 1.274104086 0.349483142 0.796886494 1 0.084746319 0.112626784 100528062 ARMCX5-GPRASP2 readthrough "GO:0001540,GO:0001664,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007611,GO:0042803,GO:0043524,GO:0050769,GO:0051965,GO:0061003,GO:0061484,GO:0070062" amyloid-beta binding|G protein-coupled receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|learning or memory|protein homodimerization activity|negative regulation of neuron apoptotic process|positive regulation of neurogenesis|positive regulation of synapse assembly|positive regulation of dendritic spine morphogenesis|hematopoietic stem cell homeostasis|extracellular exosome ARMCX6 507.7266491 526.7621476 488.6911506 0.9277264 -0.108228699 0.794077671 1 13.80167846 13.35573368 54470 armadillo repeat containing X-linked 6 "GO:0005739,GO:0005741,GO:0016021" mitochondrion|mitochondrial outer membrane|integral component of membrane ARMH1 5.059934066 9.134603715 0.985264417 0.107860663 -3.212759283 0.136251646 1 0.122845314 0.013820941 339541 armadillo like helical domain containing 1 ARMH3 2591.98326 2677.453845 2506.512676 0.936155326 -0.095180175 0.766053738 1 24.2149271 23.64541866 79591 armadillo like helical domain containing 3 "GO:0000139,GO:0005515,GO:0005829,GO:0016021,GO:1903358" Golgi membrane|protein binding|cytosol|integral component of membrane|regulation of Golgi organization ARMH4 74.24840826 57.8524902 90.64432632 1.566818058 0.647837661 0.389285688 1 0.20531319 0.335545446 145407 armadillo like helical domain containing 4 GO:0016021 integral component of membrane ARMT1 429.2132977 413.0870791 445.3395163 1.078076606 0.108459697 0.803052379 1 8.728161566 9.814955359 79624 acidic residue methyltransferase 1 "GO:0005515,GO:0006479,GO:0006974,GO:0008757,GO:0016311,GO:0016791,GO:0019899,GO:0032259,GO:0046872,GO:0051998,GO:2001020" protein binding|protein methylation|cellular response to DNA damage stimulus|S-adenosylmethionine-dependent methyltransferase activity|dephosphorylation|phosphatase activity|enzyme binding|methylation|metal ion binding|protein carboxyl O-methyltransferase activity|regulation of response to DNA damage stimulus ARNT 1426.607951 1410.788796 1442.427106 1.022425972 0.031996389 0.925721744 1 14.88882591 15.87845544 405 aryl hydrocarbon receptor nuclear translocator "GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001666,GO:0001892,GO:0001938,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006805,GO:0008134,GO:0010575,GO:0016604,GO:0017162,GO:0030154,GO:0030522,GO:0030949,GO:0033235,GO:0034751,GO:0042803,GO:0043565,GO:0043619,GO:0045648,GO:0045821,GO:0045944,GO:0046886,GO:0046982,GO:0061418,GO:0090575,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|response to hypoxia|embryonic placenta development|positive regulation of endothelial cell proliferation|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|xenobiotic metabolic process|transcription factor binding|positive regulation of vascular endothelial growth factor production|nuclear body|aryl hydrocarbon receptor binding|cell differentiation|intracellular receptor signaling pathway|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of protein sumoylation|aryl hydrocarbon receptor complex|protein homodimerization activity|sequence-specific DNA binding|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of erythrocyte differentiation|positive regulation of glycolytic process|positive regulation of transcription by RNA polymerase II|positive regulation of hormone biosynthetic process|protein heterodimerization activity|regulation of transcription from RNA polymerase II promoter in response to hypoxia|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa04066,hsa04934,hsa05200,hsa05204,hsa05211" HIF-1 signaling pathway|Cushing syndrome|Pathways in cancer|Chemical carcinogenesis|Renal cell carcinoma bHLH ARNT2 83.7447538 33.49354696 133.9959607 4.00065006 2.000234441 0.007124306 0.341973728 0.260053656 1.085199182 9915 aryl hydrocarbon receptor nuclear translocator 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0001701,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006355,GO:0006357,GO:0006805,GO:0007417,GO:0007420,GO:0008284,GO:0017162,GO:0032355,GO:0034751,GO:0043066,GO:0044877,GO:0045893,GO:0045944,GO:0046982,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|in utero embryonic development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|xenobiotic metabolic process|central nervous system development|brain development|positive regulation of cell population proliferation|aryl hydrocarbon receptor binding|response to estradiol|aryl hydrocarbon receptor complex|negative regulation of apoptotic process|protein-containing complex binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|sequence-specific double-stranded DNA binding" "hsa05200,hsa05202,hsa05211" Pathways in cancer|Transcriptional misregulation in cancer|Renal cell carcinoma ARNTL 243.0240552 280.1278473 205.9202631 0.735093869 -0.443999606 0.381263375 1 3.358780121 2.575373986 406 aryl hydrocarbon receptor nuclear translocator like "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006355,GO:0006357,GO:0007283,GO:0007623,GO:0016605,GO:0017162,GO:0032007,GO:0032922,GO:0033391,GO:0034751,GO:0042634,GO:0042753,GO:0043161,GO:0043231,GO:0043565,GO:0045599,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0050767,GO:0050796,GO:0051726,GO:0051775,GO:0051879,GO:0070888,GO:0090263,GO:0090403,GO:0120163,GO:0140297,GO:1901985,GO:1990837,GO:2000074,GO:2000323,GO:2000772,GO:2001016" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spermatogenesis|circadian rhythm|PML body|aryl hydrocarbon receptor binding|negative regulation of TOR signaling|circadian regulation of gene expression|chromatoid body|aryl hydrocarbon receptor complex|regulation of hair cycle|positive regulation of circadian rhythm|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|sequence-specific DNA binding|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of neurogenesis|regulation of insulin secretion|regulation of cell cycle|response to redox state|Hsp90 protein binding|E-box binding|positive regulation of canonical Wnt signaling pathway|oxidative stress-induced premature senescence|negative regulation of cold-induced thermogenesis|DNA-binding transcription factor binding|positive regulation of protein acetylation|sequence-specific double-stranded DNA binding|regulation of type B pancreatic cell development|negative regulation of glucocorticoid receptor signaling pathway|regulation of cellular senescence|positive regulation of skeletal muscle cell differentiation" "hsa04710,hsa04728" Circadian rhythm|Dopaminergic synapse bHLH ARNTL2 1241.331228 1070.778547 1411.883909 1.318558271 0.398961329 0.241183223 1 6.262258188 8.612836962 56938 aryl hydrocarbon receptor nuclear translocator like 2 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0006355,GO:0006357,GO:0007623,GO:0009649,GO:0034751,GO:0042753,GO:0045893,GO:0045944,GO:0046983,GO:0070888" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|circadian rhythm|entrainment of circadian clock|aryl hydrocarbon receptor complex|positive regulation of circadian rhythm|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|E-box binding" ARPC1A 3618.757697 3662.97609 3574.539303 0.975856576 -0.035258969 0.912597016 1 117.2672672 119.365474 10552 actin related protein 2/3 complex subunit 1A "GO:0003779,GO:0005634,GO:0005829,GO:0005885,GO:0015629,GO:0030036,GO:0034314,GO:0035861,GO:0038096,GO:0048013,GO:0051015,GO:0061024,GO:0070062" actin binding|nucleus|cytosol|Arp2/3 protein complex|actin cytoskeleton|actin cytoskeleton organization|Arp2/3 complex-mediated actin nucleation|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|ephrin receptor signaling pathway|actin filament binding|membrane organization|extracellular exosome "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC1B 4900.197006 5151.916495 4648.477517 0.902281223 -0.148350932 0.64397867 1 124.8451654 117.4977576 10095 actin related protein 2/3 complex subunit 1B "GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005885,GO:0005925,GO:0015629,GO:0032355,GO:0034314,GO:0036284,GO:0038096,GO:0043627,GO:0048013,GO:0051015,GO:0070062" structural constituent of cytoskeleton|protein binding|nucleus|cytosol|Arp2/3 protein complex|focal adhesion|actin cytoskeleton|response to estradiol|Arp2/3 complex-mediated actin nucleation|tubulobulbar complex|Fc-gamma receptor signaling pathway involved in phagocytosis|response to estrogen|ephrin receptor signaling pathway|actin filament binding|extracellular exosome "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC2 4864.492677 5102.183653 4626.8017 0.906827746 -0.141099562 0.660187321 1 169.225673 160.0689069 10109 actin related protein 2/3 complex subunit 2 "GO:0005200,GO:0005515,GO:0005634,GO:0005654,GO:0005768,GO:0005829,GO:0005885,GO:0005925,GO:0010592,GO:0015629,GO:0030027,GO:0030041,GO:0034314,GO:0035861,GO:0036195,GO:0038096,GO:0043005,GO:0048013,GO:0051015,GO:0061024,GO:0070062,GO:0070358,GO:0098978,GO:1900026" structural constituent of cytoskeleton|protein binding|nucleus|nucleoplasm|endosome|cytosol|Arp2/3 protein complex|focal adhesion|positive regulation of lamellipodium assembly|actin cytoskeleton|lamellipodium|actin filament polymerization|Arp2/3 complex-mediated actin nucleation|site of double-strand break|muscle cell projection membrane|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|ephrin receptor signaling pathway|actin filament binding|membrane organization|extracellular exosome|actin polymerization-dependent cell motility|glutamatergic synapse|positive regulation of substrate adhesion-dependent cell spreading "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC3 4863.360438 4890.057856 4836.663021 0.98908094 -0.015839508 0.961283689 1 261.801458 270.0970393 10094 actin related protein 2/3 complex subunit 3 "GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005885,GO:0005925,GO:0015629,GO:0016020,GO:0030027,GO:0031941,GO:0034314,GO:0035861,GO:0038096,GO:0048013,GO:0051015,GO:0061024,GO:0061850,GO:0070062,GO:0070358,GO:1990090" structural constituent of cytoskeleton|protein binding|nucleus|cytosol|Arp2/3 protein complex|focal adhesion|actin cytoskeleton|membrane|lamellipodium|filamentous actin|Arp2/3 complex-mediated actin nucleation|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|ephrin receptor signaling pathway|actin filament binding|membrane organization|growth cone leading edge|extracellular exosome|actin polymerization-dependent cell motility|cellular response to nerve growth factor stimulus "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC4 2479.400098 2423.714852 2535.085344 1.045950328 0.064814339 0.840070583 1 83.16572285 90.73427149 10093 actin related protein 2/3 complex subunit 4 "GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005885,GO:0019899,GO:0030041,GO:0030674,GO:0034314,GO:0035861,GO:0038096,GO:0042995,GO:0045010,GO:0048013,GO:0051015,GO:0061024,GO:0070062" structural constituent of cytoskeleton|protein binding|nucleus|cytosol|Arp2/3 protein complex|enzyme binding|actin filament polymerization|protein-macromolecule adaptor activity|Arp2/3 complex-mediated actin nucleation|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|cell projection|actin nucleation|ephrin receptor signaling pathway|actin filament binding|membrane organization|extracellular exosome "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC4-TTLL3 43.03442983 45.67301858 40.39584108 0.88445744 -0.177135373 0.865646255 1 0.580179901 0.535248611 100526693 ARPC4-TTLL3 readthrough ARPC5 3438.59361 3234.664671 3642.522548 1.126089693 0.171321743 0.590435552 1 22.5188116 26.45053013 10092 actin related protein 2/3 complex subunit 5 "GO:0005200,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0005885,GO:0005925,GO:0014909,GO:0015629,GO:0016477,GO:0021769,GO:0030011,GO:0030027,GO:0030036,GO:0030426,GO:0034314,GO:0034774,GO:0035861,GO:0038096,GO:0043312,GO:0048013,GO:0051015,GO:0051639,GO:0061024,GO:0061842,GO:0070062,GO:0097581,GO:1904813" structural constituent of cytoskeleton|protein binding|extracellular region|nucleus|cytoplasm|endosome|cytosol|Arp2/3 protein complex|focal adhesion|smooth muscle cell migration|actin cytoskeleton|cell migration|orbitofrontal cortex development|maintenance of cell polarity|lamellipodium|actin cytoskeleton organization|growth cone|Arp2/3 complex-mediated actin nucleation|secretory granule lumen|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|neutrophil degranulation|ephrin receptor signaling pathway|actin filament binding|actin filament network formation|membrane organization|microtubule organizing center localization|extracellular exosome|lamellipodium organization|ficolin-1-rich granule lumen "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC5L 1050.299295 1010.896145 1089.702445 1.077956871 0.108299457 0.758499934 1 16.76434954 18.84968175 81873 actin related protein 2/3 complex subunit 5 like "GO:0003674,GO:0005515,GO:0005737,GO:0005885,GO:0005925,GO:0008150,GO:0016477,GO:0034314,GO:0051015,GO:0070062,GO:0098978" molecular_function|protein binding|cytoplasm|Arp2/3 protein complex|focal adhesion|biological_process|cell migration|Arp2/3 complex-mediated actin nucleation|actin filament binding|extracellular exosome|glutamatergic synapse "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPIN 2815.909958 2089.794339 3542.025577 1.694915864 0.761213659 0.01727655 0.570800302 12.87130134 22.75550785 348110 actin related protein 2/3 complex inhibitor "GO:0005515,GO:0030027,GO:0030336,GO:0033058,GO:0051126,GO:2000393" protein binding|lamellipodium|negative regulation of cell migration|directional locomotion|negative regulation of actin nucleation|negative regulation of lamellipodium morphogenesis ARPP19 3249.368902 3163.617753 3335.12005 1.054210815 0.076163398 0.811438751 1 25.90140295 28.48175099 10776 cAMP regulated phosphoprotein 19 "GO:0000086,GO:0000278,GO:0004864,GO:0005102,GO:0005515,GO:0005654,GO:0005737,GO:0015459,GO:0019212,GO:0019888,GO:0032515,GO:0035308,GO:0045722,GO:0046326,GO:0051301,GO:0051721" G2/M transition of mitotic cell cycle|mitotic cell cycle|protein phosphatase inhibitor activity|signaling receptor binding|protein binding|nucleoplasm|cytoplasm|potassium channel regulator activity|phosphatase inhibitor activity|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|positive regulation of gluconeogenesis|positive regulation of glucose import|cell division|protein phosphatase 2A binding ARRB1 693.3826815 791.6656553 595.0997076 0.751705854 -0.411759856 0.276785781 1 5.207152287 4.082856738 408 arrestin beta 1 "GO:0000139,GO:0000187,GO:0000785,GO:0001664,GO:0001933,GO:0001934,GO:0002031,GO:0002092,GO:0003713,GO:0004402,GO:0004857,GO:0005096,GO:0005159,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005765,GO:0005768,GO:0005829,GO:0005886,GO:0005905,GO:0006357,GO:0006511,GO:0007186,GO:0008134,GO:0008284,GO:0014069,GO:0015031,GO:0016323,GO:0016567,GO:0016573,GO:0016604,GO:0030168,GO:0030331,GO:0030659,GO:0031143,GO:0031397,GO:0031398,GO:0031410,GO:0031625,GO:0031691,GO:0031692,GO:0031701,GO:0031762,GO:0031896,GO:0032088,GO:0032715,GO:0032717,GO:0034260,GO:0034393,GO:0035025,GO:0035066,GO:0035612,GO:0035615,GO:0042493,GO:0042699,GO:0043149,GO:0043161,GO:0043197,GO:0043280,GO:0043524,GO:0043547,GO:0044325,GO:0045211,GO:0045309,GO:0045746,GO:0045944,GO:0061024,GO:0070373,GO:0070374,GO:0090240,GO:1990763" Golgi membrane|activation of MAPK activity|chromatin|G protein-coupled receptor binding|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|G protein-coupled receptor internalization|positive regulation of receptor internalization|transcription coactivator activity|histone acetyltransferase activity|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|lysosomal membrane|endosome|cytosol|plasma membrane|clathrin-coated pit|regulation of transcription by RNA polymerase II|ubiquitin-dependent protein catabolic process|G protein-coupled receptor signaling pathway|transcription factor binding|positive regulation of cell population proliferation|postsynaptic density|protein transport|basolateral plasma membrane|protein ubiquitination|histone acetylation|nuclear body|platelet activation|estrogen receptor binding|cytoplasmic vesicle membrane|pseudopodium|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase binding|alpha-1A adrenergic receptor binding|alpha-1B adrenergic receptor binding|angiotensin receptor binding|follicle-stimulating hormone receptor binding|V2 vasopressin receptor binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of GTPase activity|positive regulation of smooth muscle cell apoptotic process|positive regulation of Rho protein signal transduction|positive regulation of histone acetylation|AP-2 adaptor complex binding|clathrin adaptor activity|response to drug|follicle-stimulating hormone signaling pathway|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|dendritic spine|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|ion channel binding|postsynaptic membrane|protein phosphorylated amino acid binding|negative regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|membrane organization|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone H4 acetylation|arrestin family protein binding "hsa04010,hsa04062,hsa04144,hsa04340,hsa04728,hsa04740,hsa04926,hsa04928,hsa04929,hsa05032" "MAPK signaling pathway|Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Dopaminergic synapse|Olfactory transduction|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Morphine addiction" other ARRB2 852.4138101 785.5759195 919.2517006 1.170162778 0.226709233 0.533049727 1 18.76728725 22.90676238 409 arrestin beta 2 "GO:0001664,GO:0001933,GO:0002031,GO:0002032,GO:0002092,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0005905,GO:0006366,GO:0007179,GO:0007186,GO:0007212,GO:0007420,GO:0007628,GO:0010628,GO:0014069,GO:0015031,GO:0016323,GO:0016567,GO:0016579,GO:0019899,GO:0019904,GO:0030139,GO:0030168,GO:0031397,GO:0031410,GO:0031623,GO:0031625,GO:0031691,GO:0031692,GO:0031701,GO:0031702,GO:0031748,GO:0031762,GO:0031826,GO:0031859,GO:0032088,GO:0032226,GO:0032691,GO:0032695,GO:0032715,GO:0032720,GO:0032967,GO:0033138,GO:0034122,GO:0034260,GO:0034392,GO:0042699,GO:0042802,GO:0043154,GO:0043161,GO:0043197,GO:0043422,GO:0043524,GO:0044877,GO:0045211,GO:0045953,GO:0050731,GO:0050965,GO:0051019,GO:0051897,GO:0051898,GO:0051928,GO:0060071,GO:0060079,GO:0060326,GO:0061024,GO:0070374,GO:0071889,GO:0090201,GO:1904037,GO:1990763,GO:2000573,GO:2000727" "G protein-coupled receptor binding|negative regulation of protein phosphorylation|G protein-coupled receptor internalization|desensitization of G protein-coupled receptor signaling pathway by arrestin|positive regulation of receptor internalization|signaling receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|plasma membrane|clathrin-coated pit|transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|brain development|adult walking behavior|positive regulation of gene expression|postsynaptic density|protein transport|basolateral plasma membrane|protein ubiquitination|protein deubiquitination|enzyme binding|protein domain specific binding|endocytic vesicle|platelet activation|negative regulation of protein ubiquitination|cytoplasmic vesicle|receptor internalization|ubiquitin protein ligase binding|alpha-1A adrenergic receptor binding|alpha-1B adrenergic receptor binding|angiotensin receptor binding|type 1 angiotensin receptor binding|D1 dopamine receptor binding|follicle-stimulating hormone receptor binding|type 2A serotonin receptor binding|platelet activating factor receptor binding|negative regulation of NF-kappaB transcription factor activity|positive regulation of synaptic transmission, dopaminergic|negative regulation of interleukin-1 beta production|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|negative regulation of toll-like receptor signaling pathway|negative regulation of GTPase activity|negative regulation of smooth muscle cell apoptotic process|follicle-stimulating hormone signaling pathway|identical protein binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|dendritic spine|protein kinase B binding|negative regulation of neuron apoptotic process|protein-containing complex binding|postsynaptic membrane|negative regulation of natural killer cell mediated cytotoxicity|positive regulation of peptidyl-tyrosine phosphorylation|detection of temperature stimulus involved in sensory perception of pain|mitogen-activated protein kinase binding|positive regulation of protein kinase B signaling|negative regulation of protein kinase B signaling|positive regulation of calcium ion transport|Wnt signaling pathway, planar cell polarity pathway|excitatory postsynaptic potential|cell chemotaxis|membrane organization|positive regulation of ERK1 and ERK2 cascade|14-3-3 protein binding|negative regulation of release of cytochrome c from mitochondria|positive regulation of epithelial cell apoptotic process|arrestin family protein binding|positive regulation of DNA biosynthetic process|positive regulation of cardiac muscle cell differentiation" "hsa04010,hsa04062,hsa04144,hsa04340,hsa04728,hsa04740,hsa04926,hsa04928,hsa04929,hsa05032" "MAPK signaling pathway|Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Dopaminergic synapse|Olfactory transduction|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Morphine addiction" ARRDC1 549.7933819 539.9565752 559.6301886 1.036435547 0.051630403 0.901530834 1 6.452783313 6.975981356 92714 arrestin domain containing 1 "GO:0005515,GO:0005737,GO:0005886,GO:0006511,GO:0006858,GO:0015031,GO:0016567,GO:0031410,GO:0031625,GO:0042802,GO:0045746,GO:0070062,GO:0140112,GO:1903561,GO:1990756,GO:1990763" protein binding|cytoplasm|plasma membrane|ubiquitin-dependent protein catabolic process|extracellular transport|protein transport|protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase binding|identical protein binding|negative regulation of Notch signaling pathway|extracellular exosome|extracellular vesicle biogenesis|extracellular vesicle|ubiquitin ligase-substrate adaptor activity|arrestin family protein binding ARRDC2 331.1525183 377.5636202 284.7414164 0.7541548 -0.40706741 0.375546494 1 6.479927279 5.097374724 27106 arrestin domain containing 2 "GO:0005515,GO:0005737,GO:0005886,GO:0015031,GO:0031410" protein binding|cytoplasm|plasma membrane|protein transport|cytoplasmic vesicle ARRDC3 1401.499546 1950.745371 852.2537203 0.436886194 -1.19467058 0.000415696 0.048560168 20.20829847 9.209032339 57561 arrestin domain containing 3 "GO:0001659,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005886,GO:0015031,GO:0031651,GO:0031699,GO:0043588,GO:0051443,GO:0060613,GO:0071878,GO:0090327,GO:0120163" temperature homeostasis|protein binding|cytoplasm|lysosome|endosome|early endosome|plasma membrane|protein transport|negative regulation of heat generation|beta-3 adrenergic receptor binding|skin development|positive regulation of ubiquitin-protein transferase activity|fat pad development|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway|negative regulation of locomotion involved in locomotory behavior|negative regulation of cold-induced thermogenesis ARRDC4 48.45338412 45.67301858 51.23374966 1.121750899 0.165752341 0.86864956 1 0.569467569 0.666317704 91947 arrestin domain containing 4 "GO:0005515,GO:0005737,GO:0005768,GO:0005769,GO:0005886,GO:0015031,GO:0016567,GO:0043231,GO:0051443,GO:0140112,GO:1903561,GO:1990756" protein binding|cytoplasm|endosome|early endosome|plasma membrane|protein transport|protein ubiquitination|intracellular membrane-bounded organelle|positive regulation of ubiquitin-protein transferase activity|extracellular vesicle biogenesis|extracellular vesicle|ubiquitin ligase-substrate adaptor activity ARSA 749.1485982 865.757441 632.5397554 0.730620062 -0.452806725 0.224046025 1 10.21135542 7.781994434 410 arylsulfatase A "GO:0004065,GO:0004098,GO:0005509,GO:0005515,GO:0005576,GO:0005764,GO:0005788,GO:0006687,GO:0008484,GO:0035578,GO:0043202,GO:0043312,GO:0070062" arylsulfatase activity|cerebroside-sulfatase activity|calcium ion binding|protein binding|extracellular region|lysosome|endoplasmic reticulum lumen|glycosphingolipid metabolic process|sulfuric ester hydrolase activity|azurophil granule lumen|lysosomal lumen|neutrophil degranulation|extracellular exosome "hsa00600,hsa04142" Sphingolipid metabolism|Lysosome ARSB 594.8307537 554.1659587 635.4955487 1.14676035 0.197563928 0.615984902 1 2.098590611 2.510246231 411 arylsulfatase B "GO:0003943,GO:0004065,GO:0005576,GO:0005739,GO:0005764,GO:0005788,GO:0005791,GO:0005794,GO:0006914,GO:0007040,GO:0007041,GO:0007417,GO:0007584,GO:0009268,GO:0009986,GO:0010632,GO:0010976,GO:0030207,GO:0035578,GO:0043202,GO:0043312,GO:0043627,GO:0046872,GO:0051597,GO:0061580,GO:0070062,GO:1904813" N-acetylgalactosamine-4-sulfatase activity|arylsulfatase activity|extracellular region|mitochondrion|lysosome|endoplasmic reticulum lumen|rough endoplasmic reticulum|Golgi apparatus|autophagy|lysosome organization|lysosomal transport|central nervous system development|response to nutrient|response to pH|cell surface|regulation of epithelial cell migration|positive regulation of neuron projection development|chondroitin sulfate catabolic process|azurophil granule lumen|lysosomal lumen|neutrophil degranulation|response to estrogen|metal ion binding|response to methylmercury|colon epithelial cell migration|extracellular exosome|ficolin-1-rich granule lumen "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome ARSD 147.0607356 152.2433953 141.878076 0.931916132 -0.10172797 0.875153328 1 1.231133784 1.196735043 414 arylsulfatase D "GO:0004065,GO:0005764,GO:0005788,GO:0046872" arylsulfatase activity|lysosome|endoplasmic reticulum lumen|metal ion binding ARSG 113.2769541 166.4527788 60.10112941 0.361070148 -1.469648948 0.025791769 0.714976983 1.266182943 0.47687436 22901 arylsulfatase G "GO:0004065,GO:0005615,GO:0005764,GO:0005783,GO:0005788,GO:0006790,GO:0046872" arylsulfatase activity|extracellular space|lysosome|endoplasmic reticulum|endoplasmic reticulum lumen|sulfur compound metabolic process|metal ion binding hsa04142 Lysosome ARSI 53.99110462 53.79266632 54.18954291 1.007377894 0.010604978 1 1 0.875171468 0.919605366 340075 arylsulfatase family member I "GO:0004065,GO:0005515,GO:0005576,GO:0005788,GO:0046872" arylsulfatase activity|protein binding|extracellular region|endoplasmic reticulum lumen|metal ion binding ARSJ 438.4990808 408.0122993 468.9858623 1.149440502 0.200931791 0.637283261 1 3.403225227 4.080309605 79642 arylsulfatase family member J "GO:0004065,GO:0005576,GO:0005788,GO:0015629,GO:0046872" arylsulfatase activity|extracellular region|endoplasmic reticulum lumen|actin cytoskeleton|metal ion binding ARSK 258.8031316 281.1428032 236.46346 0.841079541 -0.249685852 0.618120191 1 4.249146873 3.72781835 153642 arylsulfatase family member K "GO:0004065,GO:0005576,GO:0005788,GO:0046872" arylsulfatase activity|extracellular region|endoplasmic reticulum lumen|metal ion binding ARTN 44.55686378 48.71788648 40.39584108 0.82917885 -0.270244777 0.777459936 1 1.686527057 1.458671368 9048 artemin "GO:0000165,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007405,GO:0007411,GO:0007422,GO:0008083,GO:0030116,GO:0030971,GO:0050930,GO:0061146,GO:0097021" MAPK cascade|signaling receptor binding|protein binding|extracellular region|extracellular space|signal transduction|neuroblast proliferation|axon guidance|peripheral nervous system development|growth factor activity|glial cell-derived neurotrophic factor receptor binding|receptor tyrosine kinase binding|induction of positive chemotaxis|Peyer's patch morphogenesis|lymphocyte migration into lymphoid organs ARV1 226.2624359 245.6193443 206.9055275 0.842382867 -0.247452001 0.637000899 1 7.958895264 6.993236966 64801 "ARV1 homolog, fatty acid homeostasis modulator" "GO:0005515,GO:0005789,GO:0005794,GO:0006665,GO:0006695,GO:0015248,GO:0016021,GO:0016125,GO:0032366,GO:0032383,GO:0032541,GO:0090181,GO:0097036" protein binding|endoplasmic reticulum membrane|Golgi apparatus|sphingolipid metabolic process|cholesterol biosynthetic process|sterol transporter activity|integral component of membrane|sterol metabolic process|intracellular sterol transport|regulation of intracellular cholesterol transport|cortical endoplasmic reticulum|regulation of cholesterol metabolic process|regulation of plasma membrane sterol distribution ARVCF 259.2539481 244.6043884 273.9035078 1.119781659 0.163217455 0.747276119 1 1.377554694 1.609007729 421 ARVCF delta catenin family member "GO:0005515,GO:0005622,GO:0005634,GO:0005737,GO:0005886,GO:0005912,GO:0007043,GO:0007155,GO:0007275,GO:0016339,GO:0045296,GO:0098609" protein binding|intracellular anatomical structure|nucleus|cytoplasm|plasma membrane|adherens junction|cell-cell junction assembly|cell adhesion|multicellular organism development|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|cadherin binding|cell-cell adhesion ASAH1 1417.478544 1695.991423 1138.965666 0.67156334 -0.574404617 0.085840142 1 26.63441317 18.65718178 427 N-acylsphingosine amidohydrolase 1 "GO:0005576,GO:0005615,GO:0005634,GO:0005764,GO:0005769,GO:0005783,GO:0006631,GO:0006687,GO:0016810,GO:0016811,GO:0017040,GO:0017064,GO:0030216,GO:0043202,GO:0043312,GO:0046512,GO:0046513,GO:0046514,GO:0050810,GO:0062098,GO:0070062,GO:0071356,GO:0102121,GO:1904724,GO:1904813" "extracellular region|extracellular space|nucleus|lysosome|early endosome|endoplasmic reticulum|fatty acid metabolic process|glycosphingolipid metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|N-acylsphingosine amidohydrolase activity|fatty acid amide hydrolase activity|keratinocyte differentiation|lysosomal lumen|neutrophil degranulation|sphingosine biosynthetic process|ceramide biosynthetic process|ceramide catabolic process|regulation of steroid biosynthetic process|regulation of programmed necrotic cell death|extracellular exosome|cellular response to tumor necrosis factor|ceramidase activity|tertiary granule lumen|ficolin-1-rich granule lumen" "hsa00600,hsa04071,hsa04142" Sphingolipid metabolism|Sphingolipid signaling pathway|Lysosome ASAH2 52.06511311 56.83753423 47.29269199 0.832067975 -0.265226703 0.768212587 1 0.571268227 0.495809458 56624 N-acylsphingosine amidohydrolase 2 "GO:0000139,GO:0005509,GO:0005576,GO:0005739,GO:0005794,GO:0005886,GO:0005887,GO:0005901,GO:0006670,GO:0006672,GO:0006915,GO:0007346,GO:0008270,GO:0017040,GO:0042759,GO:0044241,GO:0045121,GO:0046512,GO:0046513,GO:0046514,GO:0070062,GO:0070774,GO:0071345,GO:0071633,GO:0102121,GO:2001234" Golgi membrane|calcium ion binding|extracellular region|mitochondrion|Golgi apparatus|plasma membrane|integral component of plasma membrane|caveola|sphingosine metabolic process|ceramide metabolic process|apoptotic process|regulation of mitotic cell cycle|zinc ion binding|N-acylsphingosine amidohydrolase activity|long-chain fatty acid biosynthetic process|lipid digestion|membrane raft|sphingosine biosynthetic process|ceramide biosynthetic process|ceramide catabolic process|extracellular exosome|phytoceramidase activity|cellular response to cytokine stimulus|dihydroceramidase activity|ceramidase activity|negative regulation of apoptotic signaling pathway "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway ASAH2B 109.1928819 89.31612522 129.0696386 1.445087752 0.531157102 0.422543132 1 0.867577034 1.307730331 653308 N-acylsphingosine amidohydrolase 2B "GO:0005576,GO:0017040,GO:0042759,GO:0046512,GO:0046514" extracellular region|N-acylsphingosine amidohydrolase activity|long-chain fatty acid biosynthetic process|sphingosine biosynthetic process|ceramide catabolic process ASAP1 6286.282431 6284.607356 6287.957506 1.000533072 0.000768856 0.998675802 1 46.60222428 48.63557156 50807 "ArfGAP with SH3 domain, ankyrin repeat and PH domain 1" "GO:0001786,GO:0002102,GO:0005096,GO:0005515,GO:0005546,GO:0005547,GO:0005829,GO:0031253,GO:0043197,GO:0043547,GO:0045296,GO:0046872,GO:0060271,GO:0061000,GO:0071803,GO:1903527" "phosphatidylserine binding|podosome|GTPase activator activity|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|cell projection membrane|dendritic spine|positive regulation of GTPase activity|cadherin binding|metal ion binding|cilium assembly|negative regulation of dendritic spine development|positive regulation of podosome assembly|positive regulation of membrane tubulation" "hsa04144,hsa04666" Endocytosis|Fc gamma R-mediated phagocytosis ASAP2 2170.398462 2078.629823 2262.1671 1.08829724 0.122072645 0.704188786 1 14.50472135 16.46542131 8853 "ArfGAP with SH3 domain, ankyrin repeat and PH domain 2" "GO:0005096,GO:0005515,GO:0005886,GO:0032580,GO:0043547,GO:0046872" GTPase activator activity|protein binding|plasma membrane|Golgi cisterna membrane|positive regulation of GTPase activity|metal ion binding "hsa04144,hsa04666" Endocytosis|Fc gamma R-mediated phagocytosis ASAP3 237.2097081 185.7369422 288.682474 1.554254477 0.636222735 0.212638587 1 2.197878711 3.563212959 55616 "ArfGAP with SH3 domain, ankyrin repeat and PH domain 3" "GO:0001726,GO:0005096,GO:0005515,GO:0005654,GO:0005829,GO:0005925,GO:0016477,GO:0043231,GO:0043547,GO:0046872,GO:0051492" ruffle|GTPase activator activity|protein binding|nucleoplasm|cytosol|focal adhesion|cell migration|intracellular membrane-bounded organelle|positive regulation of GTPase activity|metal ion binding|regulation of stress fiber assembly "hsa04144,hsa04666" Endocytosis|Fc gamma R-mediated phagocytosis ASB1 1838.962636 1513.299349 2164.625923 1.430401675 0.516420331 0.111799861 1 11.12222804 16.59455974 51665 ankyrin repeat and SOCS box containing 1 "GO:0000151,GO:0001818,GO:0005515,GO:0005829,GO:0016567,GO:0030539,GO:0035556,GO:0043687,GO:0061630" ubiquitin ligase complex|negative regulation of cytokine production|protein binding|cytosol|protein ubiquitination|male genitalia development|intracellular signal transduction|post-translational protein modification|ubiquitin protein ligase activity ASB12 4.493072978 4.059823873 4.926322083 1.213432463 0.279093814 1 1 0.162285522 0.205405145 142689 ankyrin repeat and SOCS box containing 12 "GO:0000151,GO:0005515,GO:0005829,GO:0016567,GO:0043687,GO:0061630" ubiquitin ligase complex|protein binding|cytosol|protein ubiquitination|post-translational protein modification|ubiquitin protein ligase activity ASB13 689.5955248 734.8281211 644.3629284 0.876889316 -0.189533343 0.618643352 1 13.6976268 12.5287008 79754 ankyrin repeat and SOCS box containing 13 "GO:0005515,GO:0005829,GO:0016567,GO:0035556,GO:0043687" protein binding|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB2 37.92723683 66.98709391 8.867379749 0.132374451 -2.917303399 0.003603932 0.216140264 1.104381507 0.152489249 51676 ankyrin repeat and SOCS box containing 2 "GO:0000151,GO:0005515,GO:0005829,GO:0006511,GO:0007165,GO:0016567,GO:0035556,GO:0035914,GO:0043687,GO:0061630" ubiquitin ligase complex|protein binding|cytosol|ubiquitin-dependent protein catabolic process|signal transduction|protein ubiquitination|intracellular signal transduction|skeletal muscle cell differentiation|post-translational protein modification|ubiquitin protein ligase activity ASB3 9.478778165 8.119647747 10.83790858 1.334775709 0.416597337 0.834100552 1 0.148889035 0.207294099 51130 ankyrin repeat and SOCS box containing 3 "GO:0005515,GO:0005829,GO:0016567,GO:0030315,GO:0035556,GO:0036371,GO:0043687,GO:0055117" protein binding|cytosol|protein ubiquitination|T-tubule|intracellular signal transduction|protein localization to T-tubule|post-translational protein modification|regulation of cardiac muscle contraction ASB6 912.8927649 912.4454156 913.3401141 1.00098055 0.001413942 1 1 10.03957015 10.48230247 140459 ankyrin repeat and SOCS box containing 6 "GO:0005515,GO:0005829,GO:0016567,GO:0035556,GO:0043687" protein binding|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB7 789.599863 734.8281211 844.371605 1.149073614 0.200471226 0.58761013 1 7.307373261 8.758406008 140460 ankyrin repeat and SOCS box containing 7 "GO:0005515,GO:0005829,GO:0016567,GO:0035556,GO:0043687" protein binding|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB8 395.5010235 465.8647895 325.1372575 0.69792194 -0.51886241 0.233237011 1 8.352002873 6.080137707 140461 ankyrin repeat and SOCS box containing 8 "GO:0005515,GO:0005829,GO:0016567,GO:0035556,GO:0043687" protein binding|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB9 35.49648894 35.52345889 35.469519 0.99848157 -0.002192297 1 1 0.887586519 0.924414353 140462 ankyrin repeat and SOCS box containing 9 "GO:0005515,GO:0005739,GO:0005829,GO:0016567,GO:0035556,GO:0043687,GO:0045732" protein binding|mitochondrion|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification|positive regulation of protein catabolic process ASCC1 1174.717754 1299.14364 1050.291868 0.808449379 -0.306770653 0.371594293 1 12.78108824 10.77796067 51008 activating signal cointegrator 1 complex subunit 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006307,GO:0006355,GO:0016607,GO:0031594" "RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|DNA dealkylation involved in DNA repair|regulation of transcription, DNA-templated|nuclear speck|neuromuscular junction" ASCC2 1069.248686 1127.616081 1010.881291 0.896476477 -0.157662367 0.65219261 1 17.64281017 16.49766913 84164 activating signal cointegrator 1 complex subunit 2 "GO:0005515,GO:0005634,GO:0005654,GO:0006307,GO:0006355,GO:0016607,GO:0043130,GO:0099053" "protein binding|nucleus|nucleoplasm|DNA dealkylation involved in DNA repair|regulation of transcription, DNA-templated|nuclear speck|ubiquitin binding|activating signal cointegrator 1 complex" ASCC3 1416.745904 1342.786746 1490.705062 1.110157712 0.150764645 0.652674717 1 5.704362659 6.605531051 10973 activating signal cointegrator 1 complex subunit 3 "GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006307,GO:0008283,GO:0016020,GO:0016607,GO:0032508,GO:0043138,GO:0099053" RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA dealkylation involved in DNA repair|cell population proliferation|membrane|nuclear speck|DNA duplex unwinding|3'-5' DNA helicase activity|activating signal cointegrator 1 complex ASCL5 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.025247514 0.102258671 647219 achaete-scute family bHLH transcription factor 5 "GO:0000785,GO:0000977,GO:0000981,GO:0003674,GO:0005575,GO:0006357,GO:0008150,GO:0045944,GO:0046983,GO:0090575" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|cellular_component|regulation of transcription by RNA polymerase II|biological_process|positive regulation of transcription by RNA polymerase II|protein dimerization activity|RNA polymerase II transcription regulator complex" ASF1A 264.5932303 306.5167024 222.6697581 0.726452283 -0.461060058 0.349702245 1 6.377974385 4.832877567 25842 anti-silencing function 1A histone chaperone "GO:0000785,GO:0001649,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006334,GO:0006335,GO:0006336,GO:0031936,GO:0032991,GO:0042393,GO:0042692" chromatin|osteoblast differentiation|chromatin binding|protein binding|nucleus|nucleoplasm|DNA repair|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|negative regulation of chromatin silencing|protein-containing complex|histone binding|muscle cell differentiation ASF1B 1331.982235 1172.274143 1491.690327 1.27247567 0.347638072 0.302153842 1 35.15189451 46.65671454 55723 anti-silencing function 1B histone chaperone "GO:0000785,GO:0001835,GO:0005515,GO:0005654,GO:0006335,GO:0006336,GO:0007283,GO:0030154,GO:0032991,GO:0042393" chromatin|blastocyst hatching|protein binding|nucleoplasm|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|spermatogenesis|cell differentiation|protein-containing complex|histone binding ASGR1 34.4073041 28.41876711 40.39584108 1.421449457 0.507362801 0.606814909 1 1.098710152 1.629035276 432 asialoglycoprotein receptor 1 "GO:0004873,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006898,GO:0016032,GO:0018279,GO:0030246,GO:0031668,GO:0046872" asialoglycoprotein receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|viral process|protein N-linked glycosylation via asparagine|carbohydrate binding|cellular response to extracellular stimulus|metal ion binding hsa04918 Thyroid hormone synthesis ASH1L 2008.594886 2400.370865 1616.818908 0.67357046 -0.570099226 0.077258735 1 10.02311125 7.042089055 55870 ASH1 like histone lysine methyltransferase "GO:0001501,GO:0002674,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005694,GO:0005794,GO:0005923,GO:0007338,GO:0009791,GO:0030317,GO:0042800,GO:0043124,GO:0043409,GO:0045944,GO:0046697,GO:0046872,GO:0046974,GO:0046975,GO:0051567,GO:0051568,GO:0061038,GO:0097676,GO:1903699,GO:1903709" skeletal system development|negative regulation of acute inflammatory response|DNA binding|chromatin binding|nucleus|nucleoplasm|chromosome|Golgi apparatus|bicellular tight junction|single fertilization|post-embryonic development|flagellated sperm motility|histone methyltransferase activity (H3-K4 specific)|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of MAPK cascade|positive regulation of transcription by RNA polymerase II|decidualization|metal ion binding|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K36 specific)|histone H3-K9 methylation|histone H3-K4 methylation|uterus morphogenesis|histone H3-K36 dimethylation|tarsal gland development|uterine gland development hsa00310 Lysine degradation ASH2L 869.4480965 771.366536 967.529657 1.254305978 0.326889325 0.366130243 1 11.25849966 14.72990483 9070 "ASH2 like, histone lysine methyltransferase complex subunit" "GO:0000976,GO:0005515,GO:0005634,GO:0005654,GO:0006974,GO:0008013,GO:0008284,GO:0030097,GO:0035097,GO:0042800,GO:0043627,GO:0044666,GO:0045652,GO:0046872,GO:0048188,GO:0051568,GO:1904837" transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|cellular response to DNA damage stimulus|beta-catenin binding|positive regulation of cell population proliferation|hemopoiesis|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|response to estrogen|MLL3/4 complex|regulation of megakaryocyte differentiation|metal ion binding|Set1C/COMPASS complex|histone H3-K4 methylation|beta-catenin-TCF complex assembly hsa04934 Cushing syndrome ASIC1 413.2627529 501.3882484 325.1372575 0.648474029 -0.624879299 0.146171447 1 5.457456692 3.691465511 41 acid sensing ion channel subunit 1 "GO:0001662,GO:0001975,GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0006814,GO:0007165,GO:0007613,GO:0008306,GO:0009268,GO:0009986,GO:0010447,GO:0015280,GO:0022839,GO:0034220,GO:0035725,GO:0042391,GO:0044736,GO:0045202,GO:0046929,GO:0050915,GO:0070207,GO:0070588,GO:0071467" behavioral fear response|response to amphetamine|protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|sodium ion transport|signal transduction|memory|associative learning|response to pH|cell surface|response to acidic pH|ligand-gated sodium channel activity|ion gated channel activity|ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|acid-sensing ion channel activity|synapse|negative regulation of neurotransmitter secretion|sensory perception of sour taste|protein homotrimerization|calcium ion transmembrane transport|cellular response to pH hsa04750 Inflammatory mediator regulation of TRP channels ASIC3 20.95777671 18.26920743 23.646346 1.294327961 0.372203218 0.766546876 1 0.399857782 0.539840937 9311 acid sensing ion channel subunit 3 "GO:0005261,GO:0005272,GO:0005886,GO:0005887,GO:0007165,GO:0007600,GO:0009408,GO:0010447,GO:0015280,GO:0034220,GO:0035725,GO:0042930,GO:0042931,GO:0044736,GO:0048471,GO:0050915,GO:0050965,GO:0050966,GO:0050968" cation channel activity|sodium channel activity|plasma membrane|integral component of plasma membrane|signal transduction|sensory perception|response to heat|response to acidic pH|ligand-gated sodium channel activity|ion transmembrane transport|sodium ion transmembrane transport|enterobactin transport|enterobactin transmembrane transporter activity|acid-sensing ion channel activity|perinuclear region of cytoplasm|sensory perception of sour taste|detection of temperature stimulus involved in sensory perception of pain|detection of mechanical stimulus involved in sensory perception of pain|detection of chemical stimulus involved in sensory perception of pain hsa04750 Inflammatory mediator regulation of TRP channels ASL 575.5087339 614.0483609 536.969107 0.874473643 -0.193513194 0.626073612 1 14.53242208 13.25563865 435 argininosuccinate lyase "GO:0000050,GO:0004056,GO:0005515,GO:0005829,GO:0042450,GO:0042802,GO:0070062" urea cycle|argininosuccinate lyase activity|protein binding|cytosol|arginine biosynthetic process via ornithine|identical protein binding|extracellular exosome "hsa00220,hsa00250" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism" ASMTL-2 19.56895474 24.35894324 14.77896625 0.606716232 -0.720906186 0.536243558 1 0.489173094 0.309573733 8623 acetylserotonin O-methyltransferase like ASNS 664.6590801 444.5507141 884.7674461 1.990250871 0.992950294 0.009814635 0.418113748 7.053548055 14.64304449 440 asparagine synthetase (glutamine-hydrolyzing) "GO:0001889,GO:0004066,GO:0005515,GO:0005524,GO:0005829,GO:0006529,GO:0006541,GO:0008652,GO:0009416,GO:0009612,GO:0009636,GO:0031427,GO:0032354,GO:0032870,GO:0036499,GO:0042149,GO:0042802,GO:0043066,GO:0043200,GO:0045931,GO:0070981" liver development|asparagine synthase (glutamine-hydrolyzing) activity|protein binding|ATP binding|cytosol|asparagine biosynthetic process|glutamine metabolic process|cellular amino acid biosynthetic process|response to light stimulus|response to mechanical stimulus|response to toxic substance|response to methotrexate|response to follicle-stimulating hormone|cellular response to hormone stimulus|PERK-mediated unfolded protein response|cellular response to glucose starvation|identical protein binding|negative regulation of apoptotic process|response to amino acid|positive regulation of mitotic cell cycle|L-asparagine biosynthetic process hsa00250 "Alanine, aspartate and glutamate metabolism" ASNSD1 449.3491135 442.5208022 456.1774249 1.030860973 0.043849777 0.922236053 1 9.295776654 9.995435212 54529 asparagine synthetase domain containing 1 "GO:0003674,GO:0004066,GO:0005575,GO:0006529,GO:0006541,GO:0008150" molecular_function|asparagine synthase (glutamine-hydrolyzing) activity|cellular_component|asparagine biosynthetic process|glutamine metabolic process|biological_process ASPA 3.47811701 2.029911937 4.926322083 2.426864926 1.279093814 0.644064692 1 0.017976548 0.045505913 443 aspartoacylase "GO:0004046,GO:0005515,GO:0005634,GO:0005829,GO:0006533,GO:0008652,GO:0016788,GO:0016811,GO:0019807,GO:0022010,GO:0042802,GO:0046872,GO:0048714" "aminoacylase activity|protein binding|nucleus|cytosol|aspartate catabolic process|cellular amino acid biosynthetic process|hydrolase activity, acting on ester bonds|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|aspartoacylase activity|central nervous system myelination|identical protein binding|metal ion binding|positive regulation of oligodendrocyte differentiation" "hsa00250,hsa00340" "Alanine, aspartate and glutamate metabolism|Histidine metabolism" ASPH 8384.04251 8516.495531 8251.589489 0.968894947 -0.045587845 0.890988511 1 22.00328798 22.2372052 444 aspartate beta-hydroxylase "GO:0004597,GO:0005198,GO:0005509,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006936,GO:0008307,GO:0009055,GO:0016021,GO:0018215,GO:0022900,GO:0032541,GO:0033017,GO:0034220,GO:0042264,GO:0045862,GO:0062101,GO:0097202,GO:1903779" peptide-aspartate beta-dioxygenase activity|structural molecule activity|calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|muscle contraction|structural constituent of muscle|electron transfer activity|integral component of membrane|protein phosphopantetheinylation|electron transport chain|cortical endoplasmic reticulum|sarcoplasmic reticulum membrane|ion transmembrane transport|peptidyl-aspartic acid hydroxylation|positive regulation of proteolysis|peptidyl-aspartic acid 3-dioxygenase activity|activation of cysteine-type endopeptidase activity|regulation of cardiac conduction "hsa04020,hsa04260" Calcium signaling pathway|Cardiac muscle contraction ASPHD1 300.1100082 276.0680234 324.151993 1.174174354 0.231646651 0.627632283 1 4.482805859 5.490330029 253982 aspartate beta-hydroxylase domain containing 1 "GO:0016021,GO:0018193,GO:0051213,GO:0055114" integral component of membrane|peptidyl-amino acid modification|dioxygenase activity|oxidation-reduction process ASPHD2 140.1341932 150.2134833 130.054903 0.86580046 -0.207893528 0.739552398 1 2.257502376 2.038740537 57168 aspartate beta-hydroxylase domain containing 2 "GO:0016020,GO:0016021,GO:0018193,GO:0046872,GO:0051213,GO:0055114" membrane|integral component of membrane|peptidyl-amino acid modification|metal ion binding|dioxygenase activity|oxidation-reduction process ASPM 4867.86489 4019.225635 5716.504145 1.42228993 0.508215584 0.113641397 1 18.73880138 27.80006893 259266 assembly factor for spindle microtubules "GO:0005516,GO:0005634,GO:0005737,GO:0007051,GO:0036449,GO:0051301,GO:0051653,GO:0097431" calmodulin binding|nucleus|cytoplasm|spindle organization|microtubule minus-end|cell division|spindle localization|mitotic spindle pole ASPSCR1 190.4865988 157.3181751 223.6550226 1.421673131 0.507589801 0.355216578 1 3.052724361 4.526924775 79058 "ASPSCR1 tether for SLC2A4, UBX domain containing" "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006886,GO:0009898,GO:0012505,GO:0012506,GO:0019898,GO:0031401,GO:0033116,GO:0042593,GO:0043231,GO:0046324,GO:0048471" protein binding|nucleoplasm|cytosol|plasma membrane|intracellular protein transport|cytoplasmic side of plasma membrane|endomembrane system|vesicle membrane|extrinsic component of membrane|positive regulation of protein modification process|endoplasmic reticulum-Golgi intermediate compartment membrane|glucose homeostasis|intracellular membrane-bounded organelle|regulation of glucose import|perinuclear region of cytoplasm hsa05202 Transcriptional misregulation in cancer ASRGL1 85.605919 93.37594909 77.83588891 0.833575344 -0.262615489 0.723502878 1 1.727232436 1.501798186 80150 asparaginase and isoaspartyl peptidase 1 "GO:0001917,GO:0003948,GO:0004067,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0006559,GO:0008798,GO:0033345" photoreceptor inner segment|N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity|asparaginase activity|nucleus|cytoplasm|cytosol|proteolysis|L-phenylalanine catabolic process|beta-aspartyl-peptidase activity|asparagine catabolic process via L-aspartate hsa00250 "Alanine, aspartate and glutamate metabolism" ASS1 562.8514759 590.7043736 534.9985782 0.905695983 -0.142901236 0.721670649 1 13.90199472 13.13334916 445 argininosuccinate synthase 1 "GO:0000050,GO:0000052,GO:0000053,GO:0001822,GO:0001889,GO:0003723,GO:0004055,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005741,GO:0005764,GO:0005783,GO:0005829,GO:0006526,GO:0006531,GO:0006953,GO:0007494,GO:0007568,GO:0007584,GO:0007623,GO:0010043,GO:0010046,GO:0015643,GO:0016597,GO:0032355,GO:0042493,GO:0042802,GO:0043204,GO:0045429,GO:0060416,GO:0060539,GO:0070062,GO:0070852,GO:0071222,GO:0071230,GO:0071242,GO:0071320,GO:0071346,GO:0071356,GO:0071377,GO:0071400,GO:0071418,GO:0071499,GO:0071549,GO:1903038" urea cycle|citrulline metabolic process|argininosuccinate metabolic process|kidney development|liver development|RNA binding|argininosuccinate synthase activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrial outer membrane|lysosome|endoplasmic reticulum|cytosol|arginine biosynthetic process|aspartate metabolic process|acute-phase response|midgut development|aging|response to nutrient|circadian rhythm|response to zinc ion|response to mycotoxin|toxic substance binding|amino acid binding|response to estradiol|response to drug|identical protein binding|perikaryon|positive regulation of nitric oxide biosynthetic process|response to growth hormone|diaphragm development|extracellular exosome|cell body fiber|cellular response to lipopolysaccharide|cellular response to amino acid stimulus|cellular response to ammonium ion|cellular response to cAMP|cellular response to interferon-gamma|cellular response to tumor necrosis factor|cellular response to glucagon stimulus|cellular response to oleic acid|cellular response to amine stimulus|cellular response to laminar fluid shear stress|cellular response to dexamethasone stimulus|negative regulation of leukocyte cell-cell adhesion "hsa00220,hsa00250,hsa05418" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Fluid shear stress and atherosclerosis" ASTE1 93.08447678 99.4656849 86.70326866 0.871690259 -0.198112507 0.787198484 1 1.251574173 1.137980225 28990 asteroid homolog 1 "GO:0004518,GO:0005515,GO:0090305" nuclease activity|protein binding|nucleic acid phosphodiester bond hydrolysis ASTN2 62.57369302 68.00204988 57.14533616 0.840347258 -0.250942477 0.765476187 1 0.337421762 0.2957657 23245 astrotactin 2 "GO:0001764,GO:0005509,GO:0005768,GO:0005769,GO:0005770,GO:0005938,GO:0007158,GO:0015031,GO:0016021,GO:0030136,GO:0043204,GO:0043533,GO:0048105,GO:0060187,GO:2000009" "neuron migration|calcium ion binding|endosome|early endosome|late endosome|cell cortex|neuron cell-cell adhesion|protein transport|integral component of membrane|clathrin-coated vesicle|perikaryon|inositol 1,3,4,5 tetrakisphosphate binding|establishment of body hair planar orientation|cell pole|negative regulation of protein localization to cell surface" ASXL1 6678.667326 6335.355155 7021.979497 1.108379771 0.148452286 0.649497796 1 31.53138648 36.45420138 171023 ASXL transcriptional regulator 1 "GO:0000902,GO:0003007,GO:0003677,GO:0003682,GO:0003713,GO:0005515,GO:0005654,GO:0006351,GO:0009887,GO:0010888,GO:0016579,GO:0030097,GO:0032526,GO:0035359,GO:0035517,GO:0035522,GO:0035564,GO:0042974,GO:0042975,GO:0045599,GO:0045944,GO:0046872,GO:0048386,GO:0048538,GO:0048539,GO:0048872,GO:0060430,GO:0072015" "cell morphogenesis|heart morphogenesis|DNA binding|chromatin binding|transcription coactivator activity|protein binding|nucleoplasm|transcription, DNA-templated|animal organ morphogenesis|negative regulation of lipid storage|protein deubiquitination|hemopoiesis|response to retinoic acid|negative regulation of peroxisome proliferator activated receptor signaling pathway|PR-DUB complex|monoubiquitinated histone H2A deubiquitination|regulation of kidney size|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|negative regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of retinoic acid receptor signaling pathway|thymus development|bone marrow development|homeostasis of number of cells|lung saccule development|glomerular visceral epithelial cell development" other ASXL2 1567.14298 1588.406091 1545.87987 0.97322711 -0.039151586 0.907369148 1 6.082501506 6.17465011 55252 ASXL transcriptional regulator 2 "GO:0003677,GO:0003682,GO:0005654,GO:0006351,GO:0009887,GO:0010884,GO:0016579,GO:0035360,GO:0035517,GO:0042975,GO:0045600,GO:0045944,GO:0046872" "DNA binding|chromatin binding|nucleoplasm|transcription, DNA-templated|animal organ morphogenesis|positive regulation of lipid storage|protein deubiquitination|positive regulation of peroxisome proliferator activated receptor signaling pathway|PR-DUB complex|peroxisome proliferator activated receptor binding|positive regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding" ATAD1 1985.484718 1864.474114 2106.495323 1.129806688 0.176075945 0.585506735 1 12.11716109 14.27976145 84896 ATPase family AAA domain containing 1 "GO:0002092,GO:0005524,GO:0005778,GO:0007612,GO:0007613,GO:0016020,GO:0016887,GO:0045211,GO:0051967,GO:0098978,GO:0099149" "positive regulation of receptor internalization|ATP binding|peroxisomal membrane|learning|memory|membrane|ATPase activity|postsynaptic membrane|negative regulation of synaptic transmission, glutamatergic|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization" ATAD2 6006.991883 4973.284245 7040.699521 1.415704226 0.501519883 0.122699559 1 45.40820305 67.05370414 29028 ATPase family AAA domain containing 2 "GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006325,GO:0006357,GO:0016887,GO:0031936,GO:0042393,GO:0045893,GO:0045944,GO:0070062" "chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|ATPase activity|negative regulation of chromatin silencing|histone binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|extracellular exosome" ATAD2B 206.9903967 241.5595205 172.4212729 0.713783802 -0.486440933 0.362540963 1 0.800244475 0.59580659 54454 ATPase family AAA domain containing 2B "GO:0003682,GO:0005524,GO:0005634,GO:0005654,GO:0016887,GO:0031936,GO:0042393,GO:0045944,GO:0070577" chromatin binding|ATP binding|nucleus|nucleoplasm|ATPase activity|negative regulation of chromatin silencing|histone binding|positive regulation of transcription by RNA polymerase II|lysine-acetylated histone binding ATAD3A 1396.415609 1502.134833 1290.696386 0.859241366 -0.218864645 0.513576018 1 26.38842528 23.65073169 55210 ATPase family AAA domain containing 3A "GO:0001558,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0007005,GO:0008270,GO:0016021,GO:0016887,GO:0042645,GO:0043066,GO:0140374" regulation of cell growth|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrion organization|zinc ion binding|integral component of membrane|ATPase activity|mitochondrial nucleoid|negative regulation of apoptotic process|antiviral innate immune response ATAD3B 708.7163846 762.2319322 655.200837 0.859581985 -0.218292848 0.563573032 1 7.25236866 6.502541117 83858 ATPase family AAA domain containing 3B "GO:0005524,GO:0005739,GO:0005743,GO:0005886,GO:0007005,GO:0008270,GO:0016887,GO:0030667,GO:0043312,GO:0101003" ATP binding|mitochondrion|mitochondrial inner membrane|plasma membrane|mitochondrion organization|zinc ion binding|ATPase activity|secretory granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane ATAD3C 6.522984915 8.119647747 4.926322083 0.606716232 -0.720906186 0.726457076 1 0.106426375 0.067352049 219293 ATPase family AAA domain containing 3C "GO:0005524,GO:0005739,GO:0007005,GO:0008270,GO:0016887" ATP binding|mitochondrion|mitochondrion organization|zinc ion binding|ATPase activity ATAD5 590.2270793 441.5058462 738.9483124 1.673699949 0.743040913 0.058914121 1 2.790902842 4.872347451 79915 ATPase family AAA domain containing 5 "GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0006974,GO:0031391,GO:0045740,GO:0061860,GO:0090618,GO:1902751" DNA binding|protein binding|ATP binding|nucleus|cellular response to DNA damage stimulus|Elg1 RFC-like complex|positive regulation of DNA replication|DNA clamp unloader activity|DNA clamp unloading|positive regulation of cell cycle G2/M phase transition ATAT1 89.16098649 66.98709391 111.3348791 1.662034768 0.732950562 0.299497188 1 1.32112928 2.290347352 79969 alpha tubulin acetyltransferase 1 "GO:0004468,GO:0005794,GO:0005829,GO:0005874,GO:0005905,GO:0005925,GO:0007283,GO:0018215,GO:0019799,GO:0021542,GO:0030424,GO:0045598,GO:0048666,GO:0060271,GO:0070507,GO:0071929,GO:0072686,GO:0097427,GO:1900227" "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|Golgi apparatus|cytosol|microtubule|clathrin-coated pit|focal adhesion|spermatogenesis|protein phosphopantetheinylation|tubulin N-acetyltransferase activity|dentate gyrus development|axon|regulation of fat cell differentiation|neuron development|cilium assembly|regulation of microtubule cytoskeleton organization|alpha-tubulin acetylation|mitotic spindle|microtubule bundle|positive regulation of NLRP3 inflammasome complex assembly" ATE1 654.765858 576.49499 733.0367259 1.271540497 0.34657741 0.366301407 1 4.688844948 6.218877437 11101 arginyltransferase 1 "GO:0004057,GO:0005515,GO:0005634,GO:0005737,GO:0010498,GO:0016598" arginyltransferase activity|protein binding|nucleus|cytoplasm|proteasomal protein catabolic process|protein arginylation ATF1 562.3467195 556.1958707 568.4975683 1.022117564 0.031561144 0.941331558 1 5.355391389 5.70963041 466 activating transcription factor 1 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0010976,GO:0014070,GO:0032025,GO:0034622,GO:0042802,GO:0044877,GO:0045740,GO:0045944,GO:0046982,GO:1990589,GO:1990590" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|positive regulation of neuron projection development|response to organic cyclic compound|response to cobalt ion|cellular protein-containing complex assembly|identical protein binding|protein-containing complex binding|positive regulation of DNA replication|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|ATF4-CREB1 transcription factor complex|ATF1-ATF4 transcription factor complex" "hsa04925,hsa05202" Aldosterone synthesis and secretion|Transcriptional misregulation in cancer TF_bZIP ATF2 1170.725478 1194.603175 1146.847781 0.960024052 -0.058857543 0.866117661 1 13.0224788 13.04042371 1386 activating transcription factor 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001102,GO:0001228,GO:0003151,GO:0003682,GO:0003700,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005741,GO:0006355,GO:0006357,GO:0006970,GO:0006974,GO:0008140,GO:0009414,GO:0010485,GO:0010628,GO:0016525,GO:0019901,GO:0031573,GO:0032915,GO:0035497,GO:0035861,GO:0043525,GO:0043967,GO:0043969,GO:0044013,GO:0044877,GO:0045444,GO:0045944,GO:0046872,GO:0050680,GO:0051090,GO:0051091,GO:0060612,GO:0097186,GO:0110024,GO:1902110,GO:1902562,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|outflow tract morphogenesis|chromatin binding|DNA-binding transcription factor activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial outer membrane|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|response to osmotic stress|cellular response to DNA damage stimulus|cAMP response element binding protein binding|response to water deprivation|H4 histone acetyltransferase activity|positive regulation of gene expression|negative regulation of angiogenesis|protein kinase binding|intra-S DNA damage checkpoint|positive regulation of transforming growth factor beta2 production|cAMP response element binding|site of double-strand break|positive regulation of neuron apoptotic process|histone H4 acetylation|histone H2B acetylation|H2B histone acetyltransferase activity|protein-containing complex binding|fat cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of epithelial cell proliferation|regulation of DNA-binding transcription factor activity|positive regulation of DNA-binding transcription factor activity|adipose tissue development|amelogenesis|positive regulation of cardiac muscle myoblast proliferation|positive regulation of mitochondrial membrane permeability involved in apoptotic process|H4 histone acetyltransferase complex|sequence-specific double-stranded DNA binding" "hsa04010,hsa04022,hsa04151,hsa04211,hsa04261,hsa04668,hsa04714,hsa04728,hsa04911,hsa04915,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05166,hsa05203" "MAPK signaling pathway|cGMP-PKG signaling pathway|PI3K-Akt signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis" TF_bZIP ATF3 67.72270174 83.22638941 52.21901408 0.627433371 -0.672465831 0.385615267 1 1.470733782 0.962537396 467 activating transcription factor 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006094,GO:0006357,GO:0008284,GO:0034198,GO:0035914,GO:0036499,GO:0042802,GO:0042803,GO:0045944,GO:0046982,GO:0061394,GO:0070373,GO:1903984,GO:1990440,GO:1990622,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|gluconeogenesis|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|cellular response to amino acid starvation|skeletal muscle cell differentiation|PERK-mediated unfolded protein response|identical protein binding|protein homodimerization activity|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|negative regulation of ERK1 and ERK2 cascade|positive regulation of TRAIL-activated apoptotic signaling pathway|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|CHOP-ATF3 complex|sequence-specific double-stranded DNA binding" TF_bZIP ATF4 7046.389926 5845.131422 8247.648431 1.411028741 0.496747374 0.130168968 1 38.38134139 56.49004731 468 activating transcription factor 4 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001085,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006094,GO:0006355,GO:0006357,GO:0006366,GO:0006874,GO:0007214,GO:0008022,GO:0008140,GO:0009636,GO:0010575,GO:0010628,GO:0016607,GO:0019901,GO:0030182,GO:0030282,GO:0030968,GO:0031667,GO:0032057,GO:0032590,GO:0032922,GO:0032991,GO:0034198,GO:0034399,GO:0034599,GO:0034644,GO:0034976,GO:0035162,GO:0036003,GO:0036091,GO:0036499,GO:0042149,GO:0042789,GO:0043005,GO:0043065,GO:0043267,GO:0043522,GO:0043525,GO:0043565,GO:0045667,GO:0045893,GO:0045943,GO:0045944,GO:0046982,GO:0048167,GO:0061395,GO:0070059,GO:0070169,GO:0070309,GO:0070982,GO:0090650,GO:0120163,GO:0140467,GO:0140468,GO:1903204,GO:1903351,GO:1905461,GO:1990037,GO:1990440,GO:1990589,GO:1990590,GO:1990617,GO:1990737,GO:1990837,GO:2000120" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|gluconeogenesis|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|cellular calcium ion homeostasis|gamma-aminobutyric acid signaling pathway|protein C-terminus binding|cAMP response element binding protein binding|response to toxic substance|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|nuclear speck|protein kinase binding|neuron differentiation|bone mineralization|endoplasmic reticulum unfolded protein response|response to nutrient levels|negative regulation of translational initiation in response to stress|dendrite membrane|circadian regulation of gene expression|protein-containing complex|cellular response to amino acid starvation|nuclear periphery|cellular response to oxidative stress|cellular response to UV|response to endoplasmic reticulum stress|embryonic hemopoiesis|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|PERK-mediated unfolded protein response|cellular response to glucose starvation|mRNA transcription by RNA polymerase II|neuron projection|positive regulation of apoptotic process|negative regulation of potassium ion transport|leucine zipper domain binding|positive regulation of neuron apoptotic process|sequence-specific DNA binding|regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase I|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|regulation of synaptic plasticity|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of biomineral tissue development|lens fiber cell morphogenesis|L-asparagine metabolic process|cellular response to oxygen-glucose deprivation|negative regulation of cold-induced thermogenesis|integrated stress response signaling|HRI-mediated signaling|negative regulation of oxidative stress-induced neuron death|cellular response to dopamine|positive regulation of vascular associated smooth muscle cell apoptotic process|Lewy body core|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|ATF4-CREB1 transcription factor complex|ATF1-ATF4 transcription factor complex|CHOP-ATF4 complex|response to manganese-induced endoplasmic reticulum stress|sequence-specific double-stranded DNA binding|positive regulation of sodium-dependent phosphate transport" "hsa04010,hsa04022,hsa04137,hsa04141,hsa04151,hsa04210,hsa04211,hsa04261,hsa04668,hsa04720,hsa04722,hsa04725,hsa04728,hsa04911,hsa04912,hsa04915,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04932,hsa04934,hsa04935,hsa05010,hsa05012,hsa05014,hsa05020,hsa05022,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05166,hsa05203,hsa05215" "MAPK signaling pathway|cGMP-PKG signaling pathway|Mitophagy - animal|Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Non-alcoholic fatty liver disease|Cushing syndrome|Growth hormone synthesis, secretion and action|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" ATF5 704.9670843 606.9436691 802.9904995 1.323006632 0.403820294 0.284494081 1 11.1214022 15.34749491 22809 activating transcription factor 5 "GO:0000785,GO:0000976,GO:0000977,GO:0000981,GO:0001228,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005813,GO:0005829,GO:0006355,GO:0006357,GO:0007623,GO:0008285,GO:0009791,GO:0015631,GO:0019900,GO:0021891,GO:0021930,GO:0035264,GO:0043066,GO:0043565,GO:0045444,GO:0045892,GO:0045893,GO:0045944,GO:0046605,GO:1902750" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|centrosome|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|circadian rhythm|negative regulation of cell population proliferation|post-embryonic development|tubulin binding|kinase binding|olfactory bulb interneuron development|cerebellar granule cell precursor proliferation|multicellular organism growth|negative regulation of apoptotic process|sequence-specific DNA binding|fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of centrosome cycle|negative regulation of cell cycle G2/M phase transition" TF_bZIP ATF6 1993.372277 1797.48702 2189.257534 1.217954572 0.284460323 0.377656278 1 11.53819726 14.65834636 22926 activating transcription factor 6 "GO:0000139,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0003700,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006357,GO:0006457,GO:0007165,GO:0007601,GO:0010508,GO:0016020,GO:0030176,GO:0030968,GO:0035497,GO:0036500,GO:0042802,GO:0043065,GO:0043565,GO:0045944,GO:0046982,GO:1903893,GO:1990440,GO:1990837" "Golgi membrane|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|DNA-binding transcription factor activity|protein binding|nucleus|nuclear envelope|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|protein folding|signal transduction|visual perception|positive regulation of autophagy|membrane|integral component of endoplasmic reticulum membrane|endoplasmic reticulum unfolded protein response|cAMP response element binding|ATF6-mediated unfolded protein response|identical protein binding|positive regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of ATF6-mediated unfolded protein response|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|sequence-specific double-stranded DNA binding" "hsa04141,hsa05010,hsa05012,hsa05014,hsa05022" Protein processing in endoplasmic reticulum|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases ATF6B 1599.315253 1565.062103 1633.568403 1.043772256 0.06180696 0.852615579 1 30.18464369 32.86303977 1388 activating transcription factor 6 beta "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005789,GO:0005794,GO:0006357,GO:0007165,GO:0030176,GO:0030968,GO:0032993,GO:0035497,GO:0036500,GO:0045944,GO:0090575,GO:1903892,GO:1990440,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|endoplasmic reticulum membrane|Golgi apparatus|regulation of transcription by RNA polymerase II|signal transduction|integral component of endoplasmic reticulum membrane|endoplasmic reticulum unfolded protein response|protein-DNA complex|cAMP response element binding|ATF6-mediated unfolded protein response|positive regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulator complex|negative regulation of ATF6-mediated unfolded protein response|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|sequence-specific double-stranded DNA binding" "hsa04022,hsa04141,hsa04151,hsa04211,hsa04261,hsa04668,hsa04728,hsa04911,hsa04915,hsa04918,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05166,hsa05203" "cGMP-PKG signaling pathway|Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Thyroid hormone synthesis|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis" ATF7 813.3946668 744.9776808 881.8116528 1.183675264 0.243273338 0.507335633 1 4.465146912 5.512952546 11016 activating transcription factor 7 "GO:0000781,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0008134,GO:0016032,GO:0019899,GO:0034399,GO:0035497,GO:0046872,GO:0051019,GO:1990837" "chromosome, telomeric region|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription factor binding|viral process|enzyme binding|nuclear periphery|cAMP response element binding|metal ion binding|mitogen-activated protein kinase binding|sequence-specific double-stranded DNA binding" ATF7IP 2325.407377 2336.428639 2314.386114 0.990565719 -0.013675401 0.967335886 1 11.0828761 11.45121851 55729 activating transcription factor 7 interacting protein "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006306,GO:0016032,GO:0016604,GO:0016887,GO:0031647,GO:0045892,GO:0045893,GO:0045898,GO:0050821,GO:0090309" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|DNA methylation|viral process|nuclear body|ATPase activity|regulation of protein stability|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of RNA polymerase II transcription preinitiation complex assembly|protein stabilization|positive regulation of DNA methylation-dependent heterochromatin assembly" other ATG10 301.0777053 308.5466144 293.6087961 0.951586511 -0.071593274 0.886215054 1 1.975325184 1.960662342 83734 autophagy related 10 "GO:0005515,GO:0005829,GO:0006497,GO:0006914,GO:0006983,GO:0015031,GO:0016236,GO:0018215,GO:0019777,GO:0031401,GO:0032446" protein binding|cytosol|protein lipidation|autophagy|ER overload response|protein transport|macroautophagy|protein phosphopantetheinylation|Atg12 transferase activity|positive regulation of protein modification process|protein modification by small protein conjugation "hsa04136,hsa04140" Autophagy - other|Autophagy - animal ATG101 874.9776522 879.9668246 869.9884798 0.988660544 -0.016452837 0.967105917 1 34.76381851 35.85011939 60673 autophagy related 101 "GO:0000045,GO:0000407,GO:0005515,GO:0005789,GO:0005829,GO:0016236,GO:0016241,GO:0042802,GO:0044877" autophagosome assembly|phagophore assembly site|protein binding|endoplasmic reticulum membrane|cytosol|macroautophagy|regulation of macroautophagy|identical protein binding|protein-containing complex binding "hsa04136,hsa04140,hsa04211,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - other|Autophagy - animal|Longevity regulating pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATG12 1014.627378 929.699667 1099.555089 1.182699239 0.242083242 0.491661683 1 11.65495256 14.37807542 9140 autophagy related 12 "GO:0000045,GO:0000422,GO:0005515,GO:0005776,GO:0005829,GO:0006501,GO:0016032,GO:0016236,GO:0030670,GO:0034045,GO:0034274,GO:0044804" autophagosome assembly|autophagy of mitochondrion|protein binding|autophagosome|cytosol|C-terminal protein lipidation|viral process|macroautophagy|phagocytic vesicle membrane|phagophore assembly site membrane|Atg12-Atg5-Atg16 complex|autophagy of nucleus "hsa04068,hsa04136,hsa04140,hsa04621,hsa04622,hsa05131" FoxO signaling pathway|Autophagy - other|Autophagy - animal|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Shigellosis ATG13 2552.320551 2289.740665 2814.900438 1.229353386 0.297899687 0.35036817 1 20.51429099 26.3056588 9776 autophagy related 13 "GO:0000045,GO:0000407,GO:0000423,GO:0005515,GO:0005739,GO:0005789,GO:0005829,GO:0016236,GO:0016241,GO:0019898,GO:0019901,GO:0034497,GO:0034727,GO:0098780,GO:1903955,GO:1990316" autophagosome assembly|phagophore assembly site|mitophagy|protein binding|mitochondrion|endoplasmic reticulum membrane|cytosol|macroautophagy|regulation of macroautophagy|extrinsic component of membrane|protein kinase binding|protein localization to phagophore assembly site|piecemeal microautophagy of the nucleus|response to mitochondrial depolarisation|positive regulation of protein targeting to mitochondrion|Atg1/ULK1 kinase complex "hsa04136,hsa04140,hsa04211,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - other|Autophagy - animal|Longevity regulating pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATG14 552.5913148 461.8049656 643.377664 1.393180481 0.478382165 0.230374262 1 4.891006348 7.107576412 22863 autophagy related 14 "GO:0000045,GO:0000421,GO:0000423,GO:0001932,GO:0001933,GO:0001934,GO:0005515,GO:0005776,GO:0005789,GO:0005829,GO:0005930,GO:0008333,GO:0009267,GO:0010608,GO:0016236,GO:0016240,GO:0034045,GO:0035032,GO:0042149,GO:0043552,GO:0044233,GO:0045335,GO:0051020,GO:0061635,GO:0090207,GO:0097629,GO:0097632,GO:0098780" "autophagosome assembly|autophagosome membrane|mitophagy|regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|protein binding|autophagosome|endoplasmic reticulum membrane|cytosol|axoneme|endosome to lysosome transport|cellular response to starvation|posttranscriptional regulation of gene expression|macroautophagy|autophagosome membrane docking|phagophore assembly site membrane|phosphatidylinositol 3-kinase complex, class III|cellular response to glucose starvation|positive regulation of phosphatidylinositol 3-kinase activity|mitochondria-associated endoplasmic reticulum membrane|phagocytic vesicle|GTPase binding|regulation of protein complex stability|regulation of triglyceride metabolic process|extrinsic component of omegasome membrane|extrinsic component of phagophore assembly site membrane|response to mitochondrial depolarisation" "hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131,hsa05167" Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection ATG16L1 553.9125889 552.1360468 555.6891309 1.006435161 0.00925423 0.986583926 1 8.285553467 8.698077135 55054 autophagy related 16 like 1 "GO:0000045,GO:0000421,GO:0005515,GO:0005776,GO:0005829,GO:0005930,GO:0015031,GO:0016236,GO:0018215,GO:0019787,GO:0034045,GO:0039689,GO:0042802,GO:0051020" autophagosome assembly|autophagosome membrane|protein binding|autophagosome|cytosol|axoneme|protein transport|macroautophagy|protein phosphopantetheinylation|ubiquitin-like protein transferase activity|phagophore assembly site membrane|negative stranded viral RNA replication|identical protein binding|GTPase binding "hsa04136,hsa04140,hsa04621,hsa05131" Autophagy - other|Autophagy - animal|NOD-like receptor signaling pathway|Shigellosis ATG16L2 361.8820293 289.262451 434.5016077 1.50210166 0.586982455 0.188930084 1 2.056446194 3.222052456 89849 autophagy related 16 like 2 "GO:0000045,GO:0000421,GO:0005654,GO:0005776,GO:0005829,GO:0006914,GO:0015031,GO:0039689" autophagosome assembly|autophagosome membrane|nucleoplasm|autophagosome|cytosol|autophagy|protein transport|negative stranded viral RNA replication hsa04140 Autophagy - animal ATG2A 1348.874745 1249.410797 1448.338692 1.159217365 0.213151112 0.526686985 1 9.898052435 11.9682474 23130 autophagy related 2A "GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005789,GO:0005811,GO:0019898,GO:0032266,GO:0034045,GO:0034727,GO:0044805,GO:0061709" autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|endoplasmic reticulum membrane|lipid droplet|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|piecemeal microautophagy of the nucleus|late nucleophagy|reticulophagy "hsa04136,hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - other|Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATG2B 1320.566579 1301.173551 1339.959607 1.029808518 0.042376108 0.902160391 1 5.006826479 5.37817525 55102 autophagy related 2B "GO:0000045,GO:0000407,GO:0000422,GO:0005654,GO:0005789,GO:0005811,GO:0019898,GO:0032266,GO:0034045,GO:0034727,GO:0044805,GO:0061709,GO:0120009,GO:0120013" autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|nucleoplasm|endoplasmic reticulum membrane|lipid droplet|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|piecemeal microautophagy of the nucleus|late nucleophagy|reticulophagy|intermembrane lipid transfer|lipid transfer activity "hsa04136,hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - other|Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATG3 1161.836571 1092.092622 1231.580521 1.127725337 0.173415736 0.61499025 1 18.09903097 21.28994752 64422 autophagy related 3 "GO:0000045,GO:0000153,GO:0000422,GO:0005515,GO:0005829,GO:0006464,GO:0006612,GO:0016236,GO:0016567,GO:0018215,GO:0019776,GO:0019777,GO:0019787,GO:0019899,GO:0043653,GO:0044804,GO:0050765,GO:1902017" autophagosome assembly|cytoplasmic ubiquitin ligase complex|autophagy of mitochondrion|protein binding|cytosol|cellular protein modification process|protein targeting to membrane|macroautophagy|protein ubiquitination|protein phosphopantetheinylation|Atg8 ligase activity|Atg12 transferase activity|ubiquitin-like protein transferase activity|enzyme binding|mitochondrial fragmentation involved in apoptotic process|autophagy of nucleus|negative regulation of phagocytosis|regulation of cilium assembly "hsa04136,hsa04140,hsa05167" Autophagy - other|Autophagy - animal|Kaposi sarcoma-associated herpesvirus infection ATG4A 184.8988978 213.1407534 156.6570422 0.734993378 -0.444196844 0.423618856 1 4.233265585 3.245449619 115201 autophagy related 4A cysteine peptidase "GO:0004197,GO:0005515,GO:0005737,GO:0006508,GO:0006914,GO:0008234,GO:0015031" cysteine-type endopeptidase activity|protein binding|cytoplasm|proteolysis|autophagy|cysteine-type peptidase activity|protein transport "hsa04136,hsa04140" Autophagy - other|Autophagy - animal ATG4B 811.0448288 820.0844224 802.0052351 0.97795448 -0.03216078 0.933515926 1 21.07274628 21.49590373 23192 autophagy related 4B cysteine peptidase "GO:0004175,GO:0004197,GO:0005515,GO:0005829,GO:0006508,GO:0006914,GO:0008234,GO:0015031,GO:0016236,GO:0045732,GO:0051697" endopeptidase activity|cysteine-type endopeptidase activity|protein binding|cytosol|proteolysis|autophagy|cysteine-type peptidase activity|protein transport|macroautophagy|positive regulation of protein catabolic process|protein delipidation "hsa04136,hsa04140" Autophagy - other|Autophagy - animal ATG4C 286.3014606 275.0530674 297.5498538 1.081790713 0.113421417 0.819226236 1 2.829095763 3.192322997 84938 autophagy related 4C cysteine peptidase "GO:0004197,GO:0005515,GO:0005575,GO:0005737,GO:0006508,GO:0006914,GO:0008234,GO:0015031" cysteine-type endopeptidase activity|protein binding|cellular_component|cytoplasm|proteolysis|autophagy|cysteine-type peptidase activity|protein transport "hsa04136,hsa04140" Autophagy - other|Autophagy - animal ATG4D 356.0743633 296.3671428 415.7815838 1.402927396 0.488440349 0.276678954 1 7.343419893 10.7460656 84971 autophagy related 4D cysteine peptidase "GO:0005654,GO:0005739,GO:0005759,GO:0006508,GO:0006914,GO:0006915,GO:0008234,GO:0015031" nucleoplasm|mitochondrion|mitochondrial matrix|proteolysis|autophagy|apoptotic process|cysteine-type peptidase activity|protein transport "hsa04136,hsa04140" Autophagy - other|Autophagy - animal ATG5 596.6743515 646.5269519 546.8217512 0.845783381 -0.241639882 0.538424751 1 9.818383599 8.661938038 9474 autophagy related 5 "GO:0000045,GO:0000422,GO:0001974,GO:0002718,GO:0005515,GO:0005737,GO:0005776,GO:0005829,GO:0005930,GO:0006501,GO:0006914,GO:0006915,GO:0006995,GO:0009620,GO:0016020,GO:0016236,GO:0019883,GO:0030670,GO:0031397,GO:0034045,GO:0034274,GO:0035973,GO:0039689,GO:0042311,GO:0042493,GO:0043066,GO:0043687,GO:0044233,GO:0044804,GO:0045060,GO:0048840,GO:0050765,GO:0051279,GO:0055015,GO:0060047,GO:0060548,GO:0061739,GO:0070257,GO:0071500,GO:0075044,GO:1902017,GO:2000378,GO:2000619" autophagosome assembly|autophagy of mitochondrion|blood vessel remodeling|regulation of cytokine production involved in immune response|protein binding|cytoplasm|autophagosome|cytosol|axoneme|C-terminal protein lipidation|autophagy|apoptotic process|cellular response to nitrogen starvation|response to fungus|membrane|macroautophagy|antigen processing and presentation of endogenous antigen|phagocytic vesicle membrane|negative regulation of protein ubiquitination|phagophore assembly site membrane|Atg12-Atg5-Atg16 complex|aggrephagy|negative stranded viral RNA replication|vasodilation|response to drug|negative regulation of apoptotic process|post-translational protein modification|mitochondria-associated endoplasmic reticulum membrane|autophagy of nucleus|negative thymic T cell selection|otolith development|negative regulation of phagocytosis|regulation of release of sequestered calcium ion into cytosol|ventricular cardiac muscle cell development|heart contraction|negative regulation of cell death|protein lipidation involved in autophagosome assembly|positive regulation of mucus secretion|cellular response to nitrosative stress|positive regulation by symbiont of host autophagy|regulation of cilium assembly|negative regulation of reactive oxygen species metabolic process|negative regulation of histone H4-K16 acetylation "hsa04136,hsa04137,hsa04140,hsa04211,hsa04213,hsa04216,hsa04621,hsa04622,hsa05131" Autophagy - other|Mitophagy - animal|Autophagy - animal|Longevity regulating pathway|Longevity regulating pathway - multiple species|Ferroptosis|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Shigellosis ATG7 1387.761514 1449.357123 1326.165905 0.915002855 -0.128151851 0.703182506 1 11.06661017 10.56216604 10533 autophagy related 7 "GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0005930,GO:0006497,GO:0006501,GO:0006914,GO:0006995,GO:0007568,GO:0008134,GO:0009267,GO:0009749,GO:0015031,GO:0016236,GO:0018215,GO:0019778,GO:0019779,GO:0030424,GO:0031401,GO:0032446,GO:0034727,GO:0034774,GO:0039521,GO:0042752,GO:0042803,GO:0043065,GO:0043312,GO:0044805,GO:0045732,GO:0048511,GO:0051607,GO:0061684,GO:0071315,GO:0071455,GO:0075044,GO:0090298,GO:1902617,GO:1903204,GO:1904813" autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|extracellular region|cytoplasm|cytosol|axoneme|protein lipidation|C-terminal protein lipidation|autophagy|cellular response to nitrogen starvation|aging|transcription factor binding|cellular response to starvation|response to glucose|protein transport|macroautophagy|protein phosphopantetheinylation|Atg12 activating enzyme activity|Atg8 activating enzyme activity|axon|positive regulation of protein modification process|protein modification by small protein conjugation|piecemeal microautophagy of the nucleus|secretory granule lumen|suppression by virus of host autophagy|regulation of circadian rhythm|protein homodimerization activity|positive regulation of apoptotic process|neutrophil degranulation|late nucleophagy|positive regulation of protein catabolic process|rhythmic process|defense response to virus|chaperone-mediated autophagy|cellular response to morphine|cellular response to hyperoxia|positive regulation by symbiont of host autophagy|negative regulation of mitochondrial DNA replication|response to fluoride|negative regulation of oxidative stress-induced neuron death|ficolin-1-rich granule lumen "hsa04136,hsa04140,hsa04216" Autophagy - other|Autophagy - animal|Ferroptosis ATG9A 1815.210886 1708.170895 1922.250877 1.125327028 0.17034432 0.600545358 1 22.9477002 26.93604613 79065 autophagy related 9A "GO:0000045,GO:0000407,GO:0000421,GO:0000422,GO:0005515,GO:0005768,GO:0005770,GO:0005776,GO:0005789,GO:0005802,GO:0015031,GO:0016020,GO:0016021,GO:0031902,GO:0034497,GO:0043231,GO:0044805,GO:0055037" autophagosome assembly|phagophore assembly site|autophagosome membrane|autophagy of mitochondrion|protein binding|endosome|late endosome|autophagosome|endoplasmic reticulum membrane|trans-Golgi network|protein transport|membrane|integral component of membrane|late endosome membrane|protein localization to phagophore assembly site|intracellular membrane-bounded organelle|late nucleophagy|recycling endosome "hsa04136,hsa04137,hsa04140" Autophagy - other|Mitophagy - animal|Autophagy - animal ATIC 1681.216163 1876.653586 1485.77874 0.791717103 -0.336943077 0.303256881 1 34.63771271 28.6045528 471 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase "GO:0003360,GO:0003937,GO:0004643,GO:0005829,GO:0005886,GO:0006139,GO:0006189,GO:0009116,GO:0009168,GO:0010035,GO:0016020,GO:0021549,GO:0021987,GO:0031100,GO:0042803,GO:0045296,GO:0046452,GO:0046654,GO:0070062,GO:0098761" brainstem development|IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|cytosol|plasma membrane|nucleobase-containing compound metabolic process|'de novo' IMP biosynthetic process|nucleoside metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to inorganic substance|membrane|cerebellum development|cerebral cortex development|animal organ regeneration|protein homodimerization activity|cadherin binding|dihydrofolate metabolic process|tetrahydrofolate biosynthetic process|extracellular exosome|cellular response to interleukin-7 "hsa00230,hsa00670,hsa01523" Purine metabolism|One carbon pool by folate|Antifolate resistance ATL1 317.4978717 319.71113 315.2846133 0.986154637 -0.020114205 0.972957138 1 5.766467544 5.931585608 51062 atlastin GTPase 1 "GO:0000137,GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005783,GO:0005789,GO:0005794,GO:0007029,GO:0007409,GO:0016021,GO:0030424,GO:0042802,GO:0051260,GO:0071782,GO:0098826,GO:1990809" Golgi cis cisterna|Golgi membrane|GTPase activity|protein binding|GTP binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|endoplasmic reticulum organization|axonogenesis|integral component of membrane|axon|identical protein binding|protein homooligomerization|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network membrane|endoplasmic reticulum tubular network membrane organization ATL2 707.9119911 740.9178569 674.9061253 0.910905465 -0.134626757 0.7232407 1 5.7106796 5.425965552 64225 atlastin GTPase 2 "GO:0003924,GO:0005515,GO:0005525,GO:0005783,GO:0005789,GO:0006888,GO:0007029,GO:0007030,GO:0016020,GO:0016021,GO:0042802,GO:0051260,GO:0098826,GO:1990809" GTPase activity|protein binding|GTP binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|Golgi organization|membrane|integral component of membrane|identical protein binding|protein homooligomerization|endoplasmic reticulum tubular network membrane|endoplasmic reticulum tubular network membrane organization ATL3 2251.921792 1892.892881 2610.950704 1.37934414 0.463982448 0.147531813 1 12.99029088 18.68991989 25923 atlastin GTPase 3 "GO:0003924,GO:0005515,GO:0005525,GO:0005783,GO:0005789,GO:0006888,GO:0007029,GO:0007030,GO:0016020,GO:0016021,GO:0042802,GO:0051260,GO:0071782,GO:0098826,GO:1903373" GTPase activity|protein binding|GTP binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|Golgi organization|membrane|integral component of membrane|identical protein binding|protein homooligomerization|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network membrane|positive regulation of endoplasmic reticulum tubular network organization ATM 2206.125802 2028.896981 2383.354624 1.174704604 0.232298016 0.468657407 1 8.836986116 10.82801312 472 ATM serine/threonine kinase "GO:0000077,GO:0000723,GO:0000724,GO:0000729,GO:0000781,GO:0001541,GO:0001666,GO:0001756,GO:0002331,GO:0003677,GO:0004674,GO:0004677,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005819,GO:0006260,GO:0006303,GO:0006468,GO:0006974,GO:0006975,GO:0006977,GO:0007050,GO:0007094,GO:0007131,GO:0007140,GO:0007143,GO:0007165,GO:0007420,GO:0007507,GO:0008340,GO:0008630,GO:0009791,GO:0010212,GO:0010506,GO:0010628,GO:0016303,GO:0016572,GO:0018105,GO:0030335,GO:0030889,GO:0031410,GO:0032210,GO:0032212,GO:0033129,GO:0033151,GO:0035264,GO:0036092,GO:0036289,GO:0042159,GO:0042802,GO:0042981,GO:0043065,GO:0043231,GO:0043517,GO:0043525,GO:0044877,GO:0045141,GO:0045785,GO:0045944,GO:0046777,GO:0047485,GO:0048538,GO:0048599,GO:0051402,GO:0051972,GO:0071044,GO:0071300,GO:0071480,GO:0071481,GO:0071500,GO:0072434,GO:0090399,GO:0097694,GO:0097695,GO:0106310,GO:0106311,GO:1900034,GO:1901796,GO:1903626,GO:1903978,GO:1904262,GO:1904354,GO:1904358,GO:1904884,GO:1905843,GO:1990391" "DNA damage checkpoint|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|chromosome, telomeric region|ovarian follicle development|response to hypoxia|somitogenesis|pre-B cell allelic exclusion|DNA binding|protein serine/threonine kinase activity|DNA-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|spindle|DNA replication|double-strand break repair via nonhomologous end joining|protein phosphorylation|cellular response to DNA damage stimulus|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell cycle arrest|mitotic spindle assembly checkpoint|reciprocal meiotic recombination|male meiotic nuclear division|female meiotic nuclear division|signal transduction|brain development|heart development|determination of adult lifespan|intrinsic apoptotic signaling pathway in response to DNA damage|post-embryonic development|response to ionizing radiation|regulation of autophagy|positive regulation of gene expression|1-phosphatidylinositol-3-kinase activity|histone phosphorylation|peptidyl-serine phosphorylation|positive regulation of cell migration|negative regulation of B cell proliferation|cytoplasmic vesicle|regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|positive regulation of histone phosphorylation|V(D)J recombination|multicellular organism growth|phosphatidylinositol-3-phosphate biosynthetic process|peptidyl-serine autophosphorylation|lipoprotein catabolic process|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of neuron apoptotic process|protein-containing complex binding|meiotic telomere clustering|positive regulation of cell adhesion|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|protein N-terminus binding|thymus development|oocyte development|neuron apoptotic process|regulation of telomerase activity|histone mRNA catabolic process|cellular response to retinoic acid|cellular response to gamma radiation|cellular response to X-ray|cellular response to nitrosative stress|signal transduction involved in mitotic G2 DNA damage checkpoint|replicative senescence|establishment of RNA localization to telomere|establishment of protein-containing complex localization to telomere|protein serine kinase activity|protein threonine kinase activity|regulation of cellular response to heat|regulation of signal transduction by p53 class mediator|positive regulation of DNA catabolic process|regulation of microglial cell activation|negative regulation of TORC1 signaling|negative regulation of telomere capping|positive regulation of telomere maintenance via telomere lengthening|positive regulation of telomerase catalytic core complex assembly|regulation of cellular response to gamma radiation|DNA repair complex" "hsa01524,hsa03440,hsa04064,hsa04068,hsa04110,hsa04115,hsa04210,hsa04218,hsa05131,hsa05165,hsa05166,hsa05170,hsa05202,hsa05206" Platinum drug resistance|Homologous recombination|NF-kappa B signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Apoptosis|Cellular senescence|Shigellosis|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Transcriptional misregulation in cancer|MicroRNAs in cancer ATMIN 928.8242584 1058.599075 799.0494418 0.754817816 -0.40579962 0.255834013 1 10.39238392 8.182259598 23300 ATM interactor "GO:0000976,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006974,GO:0016604,GO:0044458,GO:0045893,GO:0045944,GO:0046872,GO:0070840,GO:1902857" "transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|nuclear body|motile cilium assembly|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|dynein complex binding|positive regulation of non-motile cilium assembly" ATN1 4039.820909 3148.393414 4931.248405 1.566274527 0.647337101 0.042922462 0.945969192 33.35181333 54.48830095 1822 atrophin 1 "GO:0000122,GO:0001085,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007417,GO:0016363,GO:0019904,GO:0030054,GO:0048471,GO:0051402" negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|central nervous system development|nuclear matrix|protein domain specific binding|cell junction|perinuclear region of cytoplasm|neuron apoptotic process ATOH1 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.116193353 0.047061179 474 atonal bHLH transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001764,GO:0003700,GO:0005634,GO:0006357,GO:0006366,GO:0007219,GO:0007411,GO:0007417,GO:0021987,GO:0030182,GO:0031490,GO:0042472,GO:0042667,GO:0042668,GO:0043066,GO:0045609,GO:0045666,GO:0045944,GO:0046983,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|neuron migration|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|Notch signaling pathway|axon guidance|central nervous system development|cerebral cortex development|neuron differentiation|chromatin DNA binding|inner ear morphogenesis|auditory receptor cell fate specification|auditory receptor cell fate determination|negative regulation of apoptotic process|positive regulation of inner ear auditory receptor cell differentiation|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|protein dimerization activity|sequence-specific double-stranded DNA binding" bHLH ATOH8 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.007899791 0.039995131 84913 atonal bHLH transcription factor 8 "GO:0000785,GO:0000978,GO:0000981,GO:0001704,GO:0001937,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0010595,GO:0010629,GO:0016607,GO:0030182,GO:0033613,GO:0035148,GO:0045603,GO:0045892,GO:0045893,GO:0046983,GO:0051450,GO:0060395,GO:0070888,GO:1902895" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|formation of primary germ layer|negative regulation of endothelial cell proliferation|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|positive regulation of endothelial cell migration|negative regulation of gene expression|nuclear speck|neuron differentiation|activating transcription factor binding|tube formation|positive regulation of endothelial cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|myoblast proliferation|SMAD protein signal transduction|E-box binding|positive regulation of pri-miRNA transcription by RNA polymerase II" ATOX1 680.6660403 764.2618442 597.0702364 0.781237793 -0.356166352 0.348944961 1 82.18082007 66.96835713 475 antioxidant 1 copper chaperone "GO:0005507,GO:0005515,GO:0005829,GO:0006825,GO:0006878,GO:0006979,GO:0016530,GO:0016531,GO:0032767" copper ion binding|protein binding|cytosol|copper ion transport|cellular copper ion homeostasis|response to oxidative stress|metallochaperone activity|copper chaperone activity|copper-dependent protein binding hsa04978 Mineral absorption ATP10D 268.0889147 276.0680234 260.109806 0.942194618 -0.085903003 0.86785376 1 2.260609778 2.221683301 57205 ATPase phospholipid transporting 10D (putative) "GO:0000287,GO:0005515,GO:0005524,GO:0005654,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0006812,GO:0016021,GO:0034220,GO:0045332,GO:0140326,GO:0140351,GO:1990531" magnesium ion binding|protein binding|ATP binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cation transport|integral component of membrane|ion transmembrane transport|phospholipid translocation|ATPase-coupled intramembrane lipid transporter activity|glycosylceramide flippase activity|phospholipid-translocating ATPase complex ATP11A 1513.722696 1674.677348 1352.768044 0.807778314 -0.30796868 0.352532598 1 8.928052606 7.522546134 23250 ATPase phospholipid transporting 11A "GO:0000287,GO:0005515,GO:0005524,GO:0005765,GO:0005769,GO:0005783,GO:0005802,GO:0005886,GO:0005887,GO:0016020,GO:0035579,GO:0043231,GO:0043312,GO:0045332,GO:0055037,GO:0070821,GO:0090555,GO:0140326,GO:0140331,GO:0140346,GO:1990531" magnesium ion binding|protein binding|ATP binding|lysosomal membrane|early endosome|endoplasmic reticulum|trans-Golgi network|plasma membrane|integral component of plasma membrane|membrane|specific granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|phospholipid translocation|recycling endosome|tertiary granule membrane|phosphatidylethanolamine flippase activity|ATPase-coupled intramembrane lipid transporter activity|aminophospholipid translocation|phosphatidylserine flippase activity|phospholipid-translocating ATPase complex ATP11B 1939.294819 1704.111071 2174.478567 1.276019272 0.351650118 0.276407158 1 11.22768492 14.94388029 23200 ATPase phospholipid transporting 11B (putative) "GO:0000287,GO:0005515,GO:0005524,GO:0005637,GO:0005769,GO:0005783,GO:0005802,GO:0005886,GO:0006811,GO:0015075,GO:0015917,GO:0016020,GO:0016021,GO:0034220,GO:0035577,GO:0043312,GO:0045332,GO:0055037,GO:0055038,GO:0140326" magnesium ion binding|protein binding|ATP binding|nuclear inner membrane|early endosome|endoplasmic reticulum|trans-Golgi network|plasma membrane|ion transport|ion transmembrane transporter activity|aminophospholipid transport|membrane|integral component of membrane|ion transmembrane transport|azurophil granule membrane|neutrophil degranulation|phospholipid translocation|recycling endosome|recycling endosome membrane|ATPase-coupled intramembrane lipid transporter activity ATP11C 1306.31538 1236.216369 1376.41439 1.113408966 0.154983606 0.647379902 1 8.178967734 9.498808648 286410 ATPase phospholipid transporting 11C "GO:0000287,GO:0002329,GO:0005515,GO:0005524,GO:0005765,GO:0005783,GO:0005789,GO:0005802,GO:0005886,GO:0005887,GO:0034220,GO:0045332,GO:0045579,GO:0055037,GO:0090555,GO:0140326,GO:0140331,GO:0140346" magnesium ion binding|pre-B cell differentiation|protein binding|ATP binding|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|trans-Golgi network|plasma membrane|integral component of plasma membrane|ion transmembrane transport|phospholipid translocation|positive regulation of B cell differentiation|recycling endosome|phosphatidylethanolamine flippase activity|ATPase-coupled intramembrane lipid transporter activity|aminophospholipid translocation|phosphatidylserine flippase activity ATP13A1 1142.791178 1238.246281 1047.336075 0.845822104 -0.241573832 0.48391104 1 16.29327251 14.37484867 57130 ATPase 13A1 "GO:0003674,GO:0005524,GO:0005789,GO:0006874,GO:0008150,GO:0015410,GO:0016020,GO:0016021,GO:0016887,GO:0034220,GO:0046872,GO:0071421" "molecular_function|ATP binding|endoplasmic reticulum membrane|cellular calcium ion homeostasis|biological_process|manganese transmembrane transporter activity, phosphorylative mechanism|membrane|integral component of membrane|ATPase activity|ion transmembrane transport|metal ion binding|manganese ion transmembrane transport" ATP13A2 1879.7415 1943.640679 1815.84232 0.93424795 -0.098122602 0.762942218 1 24.63427019 24.00588844 23400 ATPase cation transporting 13A2 "GO:0000421,GO:0005515,GO:0005524,GO:0005764,GO:0005765,GO:0005770,GO:0005771,GO:0005776,GO:0006874,GO:0006879,GO:0006882,GO:0006914,GO:0007041,GO:0008270,GO:0010628,GO:0010821,GO:0012506,GO:0016021,GO:0016241,GO:0016243,GO:0016887,GO:0019829,GO:0030003,GO:0030133,GO:0030145,GO:0031982,GO:0032585,GO:0033157,GO:0034220,GO:0034599,GO:0043005,GO:0043025,GO:0043202,GO:0046777,GO:0050714,GO:0052548,GO:0055069,GO:0055088,GO:0061462,GO:0061909,GO:0070300,GO:0071287,GO:0071294,GO:0080025,GO:0097734,GO:1900180,GO:1901215,GO:1902047,GO:1903135,GO:1903146,GO:1903543,GO:1903710,GO:1904714,GO:1905037,GO:1905103,GO:1905123,GO:1905165,GO:1905166,GO:1990938,GO:2000152" "autophagosome membrane|protein binding|ATP binding|lysosome|lysosomal membrane|late endosome|multivesicular body|autophagosome|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular zinc ion homeostasis|autophagy|lysosomal transport|zinc ion binding|positive regulation of gene expression|regulation of mitochondrion organization|vesicle membrane|integral component of membrane|regulation of macroautophagy|regulation of autophagosome size|ATPase activity|ATPase-coupled cation transmembrane transporter activity|cellular cation homeostasis|transport vesicle|manganese ion binding|vesicle|multivesicular body membrane|regulation of intracellular protein transport|ion transmembrane transport|cellular response to oxidative stress|neuron projection|neuronal cell body|lysosomal lumen|protein autophosphorylation|positive regulation of protein secretion|regulation of endopeptidase activity|zinc ion homeostasis|lipid homeostasis|protein localization to lysosome|autophagosome-lysosome fusion|phosphatidic acid binding|cellular response to manganese ion|cellular response to zinc ion|phosphatidylinositol-3,5-bisphosphate binding|extracellular exosome biogenesis|regulation of protein localization to nucleus|negative regulation of neuron death|polyamine transmembrane transport|cupric ion binding|regulation of autophagy of mitochondrion|positive regulation of exosomal secretion|spermine transmembrane transport|regulation of chaperone-mediated autophagy|autophagosome organization|integral component of lysosomal membrane|regulation of glucosylceramidase activity|regulation of lysosomal protein catabolic process|negative regulation of lysosomal protein catabolic process|peptidyl-aspartic acid autophosphorylation|regulation of ubiquitin-specific protease activity" ATP13A3 5000.002906 5205.709162 4794.296651 0.920968979 -0.118775532 0.711731987 1 24.26159974 23.30667743 79572 ATPase 13A3 "GO:0005524,GO:0006812,GO:0006874,GO:0016020,GO:0016021,GO:0016887,GO:0046872" ATP binding|cation transport|cellular calcium ion homeostasis|membrane|integral component of membrane|ATPase activity|metal ion binding ATP13A4 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.015896487 0 84239 ATPase 13A4 "GO:0005524,GO:0005886,GO:0006812,GO:0006874,GO:0016021,GO:0016887,GO:0034220,GO:0046872" ATP binding|plasma membrane|cation transport|cellular calcium ion homeostasis|integral component of membrane|ATPase activity|ion transmembrane transport|metal ion binding ATP1A1 16031.15127 15756.17645 16306.12609 1.03490375 0.049496598 0.888673795 1 111.74832 120.6304347 476 ATPase Na+/K+ transporting subunit alpha 1 "GO:0002026,GO:0002028,GO:0005391,GO:0005515,GO:0005524,GO:0005768,GO:0005783,GO:0005794,GO:0005886,GO:0005890,GO:0005901,GO:0006883,GO:0008217,GO:0010248,GO:0014069,GO:0014704,GO:0016020,GO:0016021,GO:0016311,GO:0016323,GO:0016324,GO:0016328,GO:0016791,GO:0019901,GO:0019904,GO:0030007,GO:0030315,GO:0030506,GO:0030955,GO:0031090,GO:0031402,GO:0031947,GO:0032991,GO:0034220,GO:0036126,GO:0036376,GO:0042383,GO:0042470,GO:0042493,GO:0043531,GO:0043548,GO:0045121,GO:0045822,GO:0045823,GO:0045989,GO:0046982,GO:0051087,GO:0055119,GO:0060081,GO:0060342,GO:0070062,GO:0071260,GO:0071383,GO:0086002,GO:0086004,GO:0086009,GO:0086013,GO:0086064,GO:1902600,GO:1903416,GO:1903561,GO:1903779,GO:1990239,GO:1990573" regulation of the force of heart contraction|regulation of sodium ion transport|sodium:potassium-exchanging ATPase activity|protein binding|ATP binding|endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|cellular sodium ion homeostasis|regulation of blood pressure|establishment or maintenance of transmembrane electrochemical gradient|postsynaptic density|intercalated disc|membrane|integral component of membrane|dephosphorylation|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|phosphatase activity|protein kinase binding|protein domain specific binding|cellular potassium ion homeostasis|T-tubule|ankyrin binding|potassium ion binding|organelle membrane|sodium ion binding|negative regulation of glucocorticoid biosynthetic process|protein-containing complex|ion transmembrane transport|sperm flagellum|sodium ion export across plasma membrane|sarcolemma|melanosome|response to drug|ADP binding|phosphatidylinositol 3-kinase binding|membrane raft|negative regulation of heart contraction|positive regulation of heart contraction|positive regulation of striated muscle contraction|protein heterodimerization activity|chaperone binding|relaxation of cardiac muscle|membrane hyperpolarization|photoreceptor inner segment membrane|extracellular exosome|cellular response to mechanical stimulus|cellular response to steroid hormone stimulus|cardiac muscle cell action potential involved in contraction|regulation of cardiac muscle cell contraction|membrane repolarization|membrane repolarization during cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|proton transmembrane transport|response to glycoside|extracellular vesicle|regulation of cardiac conduction|steroid hormone binding|potassium ion import across plasma membrane "hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978" cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1A3 39.03671066 8.119647747 69.95377357 8.615370488 3.106912838 0.002096496 0.147232652 0.11341189 1.019174331 478 ATPase Na+/K+ transporting subunit alpha 3 "GO:0001540,GO:0001917,GO:0005391,GO:0005515,GO:0005524,GO:0005783,GO:0005794,GO:0005886,GO:0005890,GO:0006883,GO:0010248,GO:0016020,GO:0016021,GO:0030007,GO:0030424,GO:0031090,GO:0032809,GO:0034220,GO:0036376,GO:0043025,GO:0045202,GO:0046872,GO:0051087,GO:0060075,GO:0060342,GO:0071383,GO:0086064,GO:0098984,GO:0099520,GO:1902600,GO:1903416,GO:1903561,GO:1903779,GO:1904646,GO:1990239,GO:1990535,GO:1990573" amyloid-beta binding|photoreceptor inner segment|sodium:potassium-exchanging ATPase activity|protein binding|ATP binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|sodium:potassium-exchanging ATPase complex|cellular sodium ion homeostasis|establishment or maintenance of transmembrane electrochemical gradient|membrane|integral component of membrane|cellular potassium ion homeostasis|axon|organelle membrane|neuronal cell body membrane|ion transmembrane transport|sodium ion export across plasma membrane|neuronal cell body|synapse|metal ion binding|chaperone binding|regulation of resting membrane potential|photoreceptor inner segment membrane|cellular response to steroid hormone stimulus|cell communication by electrical coupling involved in cardiac conduction|neuron to neuron synapse|ion antiporter activity involved in regulation of presynaptic membrane potential|proton transmembrane transport|response to glycoside|extracellular vesicle|regulation of cardiac conduction|cellular response to amyloid-beta|steroid hormone binding|neuron projection maintenance|potassium ion import across plasma membrane "hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978" cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1B1 1415.02231 1427.028092 1403.016529 0.983173728 -0.024481729 0.943778375 1 32.61459322 33.44707632 481 ATPase Na+/K+ transporting subunit beta 1 "GO:0001666,GO:0001671,GO:0005515,GO:0005886,GO:0005890,GO:0005901,GO:0006874,GO:0006883,GO:0007155,GO:0008022,GO:0010248,GO:0010468,GO:0010882,GO:0014704,GO:0016020,GO:0016323,GO:0016324,GO:0016328,GO:0019901,GO:0023026,GO:0030007,GO:0030315,GO:0030674,GO:0031090,GO:0032781,GO:0034220,GO:0035725,GO:0036126,GO:0036376,GO:0042383,GO:0044861,GO:0046034,GO:0046982,GO:0050821,GO:0050900,GO:0051117,GO:0055119,GO:0060048,GO:0070062,GO:0072659,GO:0086009,GO:0086013,GO:0086064,GO:0098655,GO:1901018,GO:1903278,GO:1903281,GO:1903288,GO:1903408,GO:1903561,GO:1903779,GO:1990573" response to hypoxia|ATPase activator activity|protein binding|plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|cellular calcium ion homeostasis|cellular sodium ion homeostasis|cell adhesion|protein C-terminus binding|establishment or maintenance of transmembrane electrochemical gradient|regulation of gene expression|regulation of cardiac muscle contraction by calcium ion signaling|intercalated disc|membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|protein kinase binding|MHC class II protein complex binding|cellular potassium ion homeostasis|T-tubule|protein-macromolecule adaptor activity|organelle membrane|positive regulation of ATPase activity|ion transmembrane transport|sodium ion transmembrane transport|sperm flagellum|sodium ion export across plasma membrane|sarcolemma|protein transport into plasma membrane raft|ATP metabolic process|protein heterodimerization activity|protein stabilization|leukocyte migration|ATPase binding|relaxation of cardiac muscle|cardiac muscle contraction|extracellular exosome|protein localization to plasma membrane|membrane repolarization|membrane repolarization during cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|cation transmembrane transport|positive regulation of potassium ion transmembrane transporter activity|positive regulation of sodium ion export across plasma membrane|positive regulation of calcium:sodium antiporter activity|positive regulation of potassium ion import across plasma membrane|positive regulation of sodium:potassium-exchanging ATPase activity|extracellular vesicle|regulation of cardiac conduction|potassium ion import across plasma membrane "hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978" cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1B2 9.478778165 8.119647747 10.83790858 1.334775709 0.416597337 0.834100552 1 0.120383933 0.167607231 482 ATPase Na+/K+ transporting subunit beta 2 "GO:0001671,GO:0001895,GO:0001917,GO:0005515,GO:0005737,GO:0005886,GO:0005890,GO:0006883,GO:0009897,GO:0010248,GO:0010976,GO:0016020,GO:0016324,GO:0016328,GO:0021670,GO:0021678,GO:0021944,GO:0030007,GO:0030674,GO:0031253,GO:0031589,GO:0032781,GO:0034220,GO:0036376,GO:0044298,GO:0045494,GO:0046982,GO:0050821,GO:0050900,GO:0051117,GO:0061744,GO:0071944,GO:0086009,GO:0086064,GO:0097449,GO:0097450,GO:0098984,GO:0120036,GO:0150104,GO:1901018,GO:1903278,GO:1903288,GO:1903779,GO:1903976,GO:1990573" ATPase activator activity|retina homeostasis|photoreceptor inner segment|protein binding|cytoplasm|plasma membrane|sodium:potassium-exchanging ATPase complex|cellular sodium ion homeostasis|external side of plasma membrane|establishment or maintenance of transmembrane electrochemical gradient|positive regulation of neuron projection development|membrane|apical plasma membrane|lateral plasma membrane|lateral ventricle development|third ventricle development|neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration|cellular potassium ion homeostasis|protein-macromolecule adaptor activity|cell projection membrane|cell-substrate adhesion|positive regulation of ATPase activity|ion transmembrane transport|sodium ion export across plasma membrane|cell body membrane|photoreceptor cell maintenance|protein heterodimerization activity|protein stabilization|leukocyte migration|ATPase binding|motor behavior|cell periphery|membrane repolarization|cell communication by electrical coupling involved in cardiac conduction|astrocyte projection|astrocyte end-foot|neuron to neuron synapse|plasma membrane bounded cell projection organization|transport across blood-brain barrier|positive regulation of potassium ion transmembrane transporter activity|positive regulation of sodium ion export across plasma membrane|positive regulation of potassium ion import across plasma membrane|regulation of cardiac conduction|negative regulation of glial cell migration|potassium ion import across plasma membrane "hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978" cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1B3 2371.099447 2193.319848 2548.879046 1.162110054 0.216746701 0.497763383 1 60.14288723 72.90334597 483 ATPase Na+/K+ transporting subunit beta 3 "GO:0001671,GO:0005515,GO:0005886,GO:0005890,GO:0005901,GO:0006883,GO:0010248,GO:0030007,GO:0030674,GO:0032781,GO:0034220,GO:0035725,GO:0036126,GO:0036376,GO:0042470,GO:0050821,GO:0050900,GO:0051117,GO:0070062,GO:0071805,GO:0072659,GO:0086009,GO:1901018,GO:1903278,GO:1903288,GO:1903779,GO:1990573" ATPase activator activity|protein binding|plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|cellular sodium ion homeostasis|establishment or maintenance of transmembrane electrochemical gradient|cellular potassium ion homeostasis|protein-macromolecule adaptor activity|positive regulation of ATPase activity|ion transmembrane transport|sodium ion transmembrane transport|sperm flagellum|sodium ion export across plasma membrane|melanosome|protein stabilization|leukocyte migration|ATPase binding|extracellular exosome|potassium ion transmembrane transport|protein localization to plasma membrane|membrane repolarization|positive regulation of potassium ion transmembrane transporter activity|positive regulation of sodium ion export across plasma membrane|positive regulation of potassium ion import across plasma membrane|regulation of cardiac conduction|potassium ion import across plasma membrane "hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978" cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP23 119.2506453 137.0190557 101.4822349 0.740643222 -0.433149351 0.501842468 1 4.942686466 3.818458235 91419 ATP23 metallopeptidase and ATP synthase assembly factor homolog "GO:0004222,GO:0004677,GO:0005515,GO:0005829,GO:0005886,GO:0005958,GO:0006303,GO:0006468,GO:0030054,GO:0031314,GO:0033615,GO:0034982,GO:0043231,GO:0046872" metalloendopeptidase activity|DNA-dependent protein kinase activity|protein binding|cytosol|plasma membrane|DNA-dependent protein kinase-DNA ligase 4 complex|double-strand break repair via nonhomologous end joining|protein phosphorylation|cell junction|extrinsic component of mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial protein processing|intracellular membrane-bounded organelle|metal ion binding ATP2A1 26.07709388 31.46363502 20.69055275 0.657602109 -0.604713169 0.571512629 1 0.449512586 0.308333692 487 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 "GO:0005388,GO:0005509,GO:0005515,GO:0005524,GO:0005739,GO:0005789,GO:0006816,GO:0006874,GO:0008553,GO:0008637,GO:0016021,GO:0016529,GO:0016887,GO:0030899,GO:0031095,GO:0031448,GO:0032470,GO:0032471,GO:0033017,GO:0034220,GO:0034704,GO:0034976,GO:0042803,GO:0051561,GO:0051659,GO:0070059,GO:0070509,GO:0070588,GO:0090076,GO:0106134,GO:1901896,GO:1902082,GO:1902600,GO:1903779,GO:1990036" "calcium transmembrane transporter activity, phosphorylative mechanism|calcium ion binding|protein binding|ATP binding|mitochondrion|endoplasmic reticulum membrane|calcium ion transport|cellular calcium ion homeostasis|proton-exporting ATPase activity, phosphorylative mechanism|apoptotic mitochondrial changes|integral component of membrane|sarcoplasmic reticulum|ATPase activity|calcium-dependent ATPase activity|platelet dense tubular network membrane|positive regulation of fast-twitch skeletal muscle fiber contraction|positive regulation of endoplasmic reticulum calcium ion concentration|negative regulation of endoplasmic reticulum calcium ion concentration|sarcoplasmic reticulum membrane|ion transmembrane transport|calcium channel complex|response to endoplasmic reticulum stress|protein homodimerization activity|positive regulation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|calcium ion import|calcium ion transmembrane transport|relaxation of skeletal muscle|positive regulation of cardiac muscle cell contraction|positive regulation of ATPase-coupled calcium transmembrane transporter activity|positive regulation of calcium ion import into sarcoplasmic reticulum|proton transmembrane transport|regulation of cardiac conduction|calcium ion import into sarcoplasmic reticulum" "hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04919,hsa04972,hsa05010,hsa05017,hsa05022,hsa05410,hsa05412,hsa05414" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Thyroid hormone signaling pathway|Pancreatic secretion|Alzheimer disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ATP2A2 7628.94942 8423.119582 6834.779258 0.811430871 -0.301459904 0.360366617 1 66.87588836 56.60268336 488 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 "GO:0002026,GO:0003009,GO:0005388,GO:0005509,GO:0005515,GO:0005524,GO:0005783,GO:0005789,GO:0005887,GO:0006874,GO:0006984,GO:0006996,GO:0007155,GO:0008544,GO:0008553,GO:0010460,GO:0010882,GO:0012506,GO:0014883,GO:0014898,GO:0016020,GO:0016529,GO:0016887,GO:0019899,GO:0031095,GO:0031234,GO:0031775,GO:0032469,GO:0032470,GO:0032496,GO:0032991,GO:0033017,GO:0033292,GO:0034220,GO:0034599,GO:0034605,GO:0034976,GO:0044325,GO:0044548,GO:0045822,GO:0048471,GO:0055119,GO:0061831,GO:0070296,GO:0070588,GO:0086036,GO:0086039,GO:0097470,GO:0098909,GO:0120025,GO:1900121,GO:1902600,GO:1903233,GO:1903515,GO:1903779,GO:1990036" "regulation of the force of heart contraction|skeletal muscle contraction|calcium transmembrane transporter activity, phosphorylative mechanism|calcium ion binding|protein binding|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|cellular calcium ion homeostasis|ER-nucleus signaling pathway|organelle organization|cell adhesion|epidermis development|proton-exporting ATPase activity, phosphorylative mechanism|positive regulation of heart rate|regulation of cardiac muscle contraction by calcium ion signaling|vesicle membrane|transition between fast and slow fiber|cardiac muscle hypertrophy in response to stress|membrane|sarcoplasmic reticulum|ATPase activity|enzyme binding|platelet dense tubular network membrane|extrinsic component of cytoplasmic side of plasma membrane|lutropin-choriogonadotropic hormone receptor binding|endoplasmic reticulum calcium ion homeostasis|positive regulation of endoplasmic reticulum calcium ion concentration|response to lipopolysaccharide|protein-containing complex|sarcoplasmic reticulum membrane|T-tubule organization|ion transmembrane transport|cellular response to oxidative stress|cellular response to heat|response to endoplasmic reticulum stress|ion channel binding|S100 protein binding|negative regulation of heart contraction|perinuclear region of cytoplasm|relaxation of cardiac muscle|apical ectoplasmic specialization|sarcoplasmic reticulum calcium ion transport|calcium ion transmembrane transport|regulation of cardiac muscle cell membrane potential|calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential|ribbon synapse|regulation of cardiac muscle cell action potential involved in regulation of contraction|plasma membrane bounded cell projection|negative regulation of receptor binding|proton transmembrane transport|regulation of calcium ion-dependent exocytosis of neurotransmitter|calcium ion transport from cytosol to endoplasmic reticulum|regulation of cardiac conduction|calcium ion import into sarcoplasmic reticulum" "hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04919,hsa04972,hsa05010,hsa05017,hsa05022,hsa05410,hsa05412,hsa05414" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Thyroid hormone signaling pathway|Pancreatic secretion|Alzheimer disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ATP2A3 36.52629069 38.5683268 34.48425458 0.894108131 -0.161478778 0.890475228 1 0.30153592 0.281219239 489 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 "GO:0005388,GO:0005524,GO:0005783,GO:0005789,GO:0006816,GO:0006874,GO:0006919,GO:0008553,GO:0008656,GO:0015085,GO:0016021,GO:0016529,GO:0016887,GO:0030899,GO:0031090,GO:0031095,GO:0031965,GO:0033017,GO:0034220,GO:0044325,GO:0046872,GO:0070059,GO:0070588,GO:0150104,GO:1900121,GO:1902600,GO:1903515,GO:1903779" "calcium transmembrane transporter activity, phosphorylative mechanism|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|calcium ion transport|cellular calcium ion homeostasis|activation of cysteine-type endopeptidase activity involved in apoptotic process|proton-exporting ATPase activity, phosphorylative mechanism|cysteine-type endopeptidase activator activity involved in apoptotic process|calcium ion transmembrane transporter activity|integral component of membrane|sarcoplasmic reticulum|ATPase activity|calcium-dependent ATPase activity|organelle membrane|platelet dense tubular network membrane|nuclear membrane|sarcoplasmic reticulum membrane|ion transmembrane transport|ion channel binding|metal ion binding|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|calcium ion transmembrane transport|transport across blood-brain barrier|negative regulation of receptor binding|proton transmembrane transport|calcium ion transport from cytosol to endoplasmic reticulum|regulation of cardiac conduction" "hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04919,hsa04972,hsa05010,hsa05017,hsa05022,hsa05410,hsa05412,hsa05414" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Thyroid hormone signaling pathway|Pancreatic secretion|Alzheimer disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ATP2B1 6065.457017 7286.368897 4844.545136 0.664877829 -0.588838824 0.070350567 1 47.54914056 32.97618818 490 ATPase plasma membrane Ca2+ transporting 1 "GO:0001772,GO:0001818,GO:0003056,GO:0003407,GO:0005388,GO:0005515,GO:0005516,GO:0005524,GO:0005654,GO:0005886,GO:0005887,GO:0006874,GO:0007420,GO:0007568,GO:0008217,GO:0009409,GO:0009898,GO:0015085,GO:0016020,GO:0016323,GO:0016324,GO:0016887,GO:0019829,GO:0030165,GO:0030501,GO:0032591,GO:0032809,GO:0034220,GO:0043231,GO:0045121,GO:0046872,GO:0051480,GO:0051481,GO:0051928,GO:0070062,GO:0071305,GO:0071386,GO:0098978,GO:0098982,GO:0099059,GO:0099509,GO:1900076,GO:1903779,GO:1905056,GO:1990034" "immunological synapse|negative regulation of cytokine production|regulation of vascular associated smooth muscle contraction|neural retina development|calcium transmembrane transporter activity, phosphorylative mechanism|protein binding|calmodulin binding|ATP binding|nucleoplasm|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|brain development|aging|regulation of blood pressure|response to cold|cytoplasmic side of plasma membrane|calcium ion transmembrane transporter activity|membrane|basolateral plasma membrane|apical plasma membrane|ATPase activity|ATPase-coupled cation transmembrane transporter activity|PDZ domain binding|positive regulation of bone mineralization|dendritic spine membrane|neuronal cell body membrane|ion transmembrane transport|intracellular membrane-bounded organelle|membrane raft|metal ion binding|regulation of cytosolic calcium ion concentration|negative regulation of cytosolic calcium ion concentration|positive regulation of calcium ion transport|extracellular exosome|cellular response to vitamin D|cellular response to corticosterone stimulus|glutamatergic synapse|GABA-ergic synapse|integral component of presynaptic active zone membrane|regulation of presynaptic cytosolic calcium ion concentration|regulation of cellular response to insulin stimulus|regulation of cardiac conduction|calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|calcium ion export across plasma membrane" "hsa04020,hsa04022,hsa04024,hsa04261,hsa04925,hsa04961,hsa04970,hsa04972,hsa04978" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Adrenergic signaling in cardiomyocytes|Aldosterone synthesis and secretion|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Pancreatic secretion|Mineral absorption ATP2B4 3978.139201 3309.771413 4646.506988 1.403875497 0.489414996 0.125122239 1 18.12393187 26.53975717 493 ATPase plasma membrane Ca2+ transporting 4 "GO:0003407,GO:0005388,GO:0005515,GO:0005516,GO:0005524,GO:0005886,GO:0005887,GO:0005901,GO:0006357,GO:0006874,GO:0007283,GO:0010629,GO:0010751,GO:0014832,GO:0015085,GO:0016020,GO:0016323,GO:0016525,GO:0017080,GO:0019829,GO:0019901,GO:0021766,GO:0030018,GO:0030165,GO:0030315,GO:0030317,GO:0030346,GO:0032991,GO:0033138,GO:0034220,GO:0036126,GO:0036487,GO:0043005,GO:0043231,GO:0043537,GO:0045019,GO:0045121,GO:0046872,GO:0048306,GO:0050998,GO:0051001,GO:0051480,GO:0051599,GO:0070588,GO:0070885,GO:0071872,GO:0097110,GO:0097228,GO:0097553,GO:0098703,GO:0098736,GO:0098978,GO:0099059,GO:0140199,GO:0150104,GO:1900082,GO:1901660,GO:1902083,GO:1902305,GO:1902548,GO:1902806,GO:1903078,GO:1903243,GO:1903249,GO:1903779,GO:1905145,GO:2000481" "neural retina development|calcium transmembrane transporter activity, phosphorylative mechanism|protein binding|calmodulin binding|ATP binding|plasma membrane|integral component of plasma membrane|caveola|regulation of transcription by RNA polymerase II|cellular calcium ion homeostasis|spermatogenesis|negative regulation of gene expression|negative regulation of nitric oxide mediated signal transduction|urinary bladder smooth muscle contraction|calcium ion transmembrane transporter activity|membrane|basolateral plasma membrane|negative regulation of angiogenesis|sodium channel regulator activity|ATPase-coupled cation transmembrane transporter activity|protein kinase binding|hippocampus development|Z disc|PDZ domain binding|T-tubule|flagellated sperm motility|protein phosphatase 2B binding|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|ion transmembrane transport|sperm flagellum|nitric-oxide synthase inhibitor activity|neuron projection|intracellular membrane-bounded organelle|negative regulation of blood vessel endothelial cell migration|negative regulation of nitric oxide biosynthetic process|membrane raft|metal ion binding|calcium-dependent protein binding|nitric-oxide synthase binding|negative regulation of nitric-oxide synthase activity|regulation of cytosolic calcium ion concentration|response to hydrostatic pressure|calcium ion transmembrane transport|negative regulation of calcineurin-NFAT signaling cascade|cellular response to epinephrine stimulus|scaffold protein binding|sperm principal piece|calcium ion transmembrane import into cytosol|calcium ion import across plasma membrane|negative regulation of the force of heart contraction|glutamatergic synapse|integral component of presynaptic active zone membrane|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|transport across blood-brain barrier|negative regulation of arginine catabolic process|calcium ion export|negative regulation of peptidyl-cysteine S-nitrosylation|regulation of sodium ion transmembrane transport|negative regulation of cellular response to vascular endothelial growth factor stimulus|regulation of cell cycle G1/S phase transition|positive regulation of protein localization to plasma membrane|negative regulation of cardiac muscle hypertrophy in response to stress|negative regulation of citrulline biosynthetic process|regulation of cardiac conduction|cellular response to acetylcholine|positive regulation of cAMP-dependent protein kinase activity" "hsa04020,hsa04022,hsa04024,hsa04261,hsa04925,hsa04961,hsa04970,hsa04972,hsa04978" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Adrenergic signaling in cardiomyocytes|Aldosterone synthesis and secretion|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Pancreatic secretion|Mineral absorption ATP2C1 2000.58757 1920.296692 2080.878448 1.083623409 0.115863465 0.720071969 1 23.12871654 26.14242325 27032 ATPase secretory pathway Ca2+ transporting 1 "GO:0000139,GO:0005388,GO:0005524,GO:0005783,GO:0005794,GO:0005802,GO:0005886,GO:0006816,GO:0006828,GO:0006874,GO:0008544,GO:0008553,GO:0015410,GO:0016020,GO:0016021,GO:0016339,GO:0016887,GO:0031532,GO:0032468,GO:0032472,GO:0034220,GO:0043123,GO:0046872,GO:0070588,GO:0071421,GO:1902600" "Golgi membrane|calcium transmembrane transporter activity, phosphorylative mechanism|ATP binding|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|plasma membrane|calcium ion transport|manganese ion transport|cellular calcium ion homeostasis|epidermis development|proton-exporting ATPase activity, phosphorylative mechanism|manganese transmembrane transporter activity, phosphorylative mechanism|membrane|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|ATPase activity|actin cytoskeleton reorganization|Golgi calcium ion homeostasis|Golgi calcium ion transport|ion transmembrane transport|positive regulation of I-kappaB kinase/NF-kappaB signaling|metal ion binding|calcium ion transmembrane transport|manganese ion transmembrane transport|proton transmembrane transport" ATP4B 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.205615757 0.069399552 496 ATPase H+/K+ transporting subunit beta "GO:0001671,GO:0005515,GO:0005886,GO:0005890,GO:0006883,GO:0007155,GO:0008900,GO:0010243,GO:0010248,GO:0030007,GO:0032496,GO:0032781,GO:0034220,GO:0036376,GO:0045851,GO:1990573" ATPase activator activity|protein binding|plasma membrane|sodium:potassium-exchanging ATPase complex|cellular sodium ion homeostasis|cell adhesion|potassium:proton exchanging ATPase activity|response to organonitrogen compound|establishment or maintenance of transmembrane electrochemical gradient|cellular potassium ion homeostasis|response to lipopolysaccharide|positive regulation of ATPase activity|ion transmembrane transport|sodium ion export across plasma membrane|pH reduction|potassium ion import across plasma membrane "hsa00190,hsa04966,hsa04971" Oxidative phosphorylation|Collecting duct acid secretion|Gastric acid secretion ATP5F1A 9622.607725 10374.87991 8870.335542 0.854981997 -0.226034053 0.500392913 1 82.08890283 73.20779915 498 ATP synthase F1 subunit alpha "GO:0001937,GO:0003723,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0005886,GO:0006629,GO:0006754,GO:0008180,GO:0015986,GO:0016020,GO:0016887,GO:0042288,GO:0042407,GO:0042776,GO:0043531,GO:0043532,GO:0043536,GO:0045259,GO:0045261,GO:0046933,GO:0070062" "negative regulation of endothelial cell proliferation|RNA binding|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|plasma membrane|lipid metabolic process|ATP biosynthetic process|COP9 signalosome|ATP synthesis coupled proton transport|membrane|ATPase activity|MHC class I protein binding|cristae formation|mitochondrial ATP synthesis coupled proton transport|ADP binding|angiostatin binding|positive regulation of blood vessel endothelial cell migration|proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, catalytic core F(1)|proton-transporting ATP synthase activity, rotational mechanism|extracellular exosome" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5F1B 13279.57225 13787.16187 12771.98263 0.926367787 -0.110343008 0.749650114 1 396.9705007 383.5814614 506 ATP synthase F1 subunit beta "GO:0001525,GO:0001649,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005753,GO:0005754,GO:0005759,GO:0005886,GO:0006091,GO:0006629,GO:0006754,GO:0006933,GO:0007005,GO:0009986,GO:0016020,GO:0016887,GO:0031966,GO:0042288,GO:0042407,GO:0042645,GO:0042776,GO:0043532,GO:0043536,GO:0045259,GO:0045261,GO:0046933,GO:0046961,GO:0051453,GO:0070062,GO:0098761,GO:1902600" "angiogenesis|osteoblast differentiation|protein binding|ATP binding|nucleus|mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase, catalytic core|mitochondrial matrix|plasma membrane|generation of precursor metabolites and energy|lipid metabolic process|ATP biosynthetic process|negative regulation of cell adhesion involved in substrate-bound cell migration|mitochondrion organization|cell surface|membrane|ATPase activity|mitochondrial membrane|MHC class I protein binding|cristae formation|mitochondrial nucleoid|mitochondrial ATP synthesis coupled proton transport|angiostatin binding|positive regulation of blood vessel endothelial cell migration|proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, catalytic core F(1)|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|regulation of intracellular pH|extracellular exosome|cellular response to interleukin-7|proton transmembrane transport" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5F1C 3203.454145 3291.502205 3115.406085 0.946499771 -0.079325937 0.803732453 1 148.9749553 147.0786744 509 ATP synthase F1 subunit gamma "GO:0000275,GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0006119,GO:0006754,GO:0015986,GO:0016020,GO:0016887,GO:0042407,GO:0042776,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)|RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|oxidative phosphorylation|ATP biosynthetic process|ATP synthesis coupled proton transport|membrane|ATPase activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5F1D 922.5388059 1066.718723 778.3588891 0.729675848 -0.454672392 0.203549823 1 77.28975701 58.82580018 513 ATP synthase F1 subunit delta "GO:0000275,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0006119,GO:0006754,GO:0009060,GO:0015986,GO:0016887,GO:0033615,GO:0042407,GO:0042776,GO:0043531,GO:0046688,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|oxidative phosphorylation|ATP biosynthetic process|aerobic respiration|ATP synthesis coupled proton transport|ATPase activity|mitochondrial proton-transporting ATP synthase complex assembly|cristae formation|mitochondrial ATP synthesis coupled proton transport|ADP binding|response to copper ion|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5F1E 4406.187109 4653.573115 4158.801102 0.893679115 -0.162171186 0.611984225 1 65.28727464 60.85917743 514 ATP synthase F1 subunit epsilon "GO:0000275,GO:0005515,GO:0005743,GO:0005753,GO:0005759,GO:0006754,GO:0016887,GO:0042407,GO:0042776,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)|protein binding|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|ATP biosynthetic process|ATPase activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5IF1 964.2480023 887.0715164 1041.424488 1.17400285 0.231435911 0.514804417 1 77.59420191 95.0198524 93974 ATP synthase inhibitory factor subunit 1 "GO:0001525,GO:0001937,GO:0004857,GO:0005515,GO:0005516,GO:0005739,GO:0006091,GO:0006783,GO:0009986,GO:0019899,GO:0030218,GO:0032780,GO:0032991,GO:0042030,GO:0042802,GO:0042803,GO:0043532,GO:0051117,GO:0051346,GO:0051882,GO:0072593,GO:0140260,GO:1901030,GO:1903052,GO:1903214,GO:1903578,GO:1904925" angiogenesis|negative regulation of endothelial cell proliferation|enzyme inhibitor activity|protein binding|calmodulin binding|mitochondrion|generation of precursor metabolites and energy|heme biosynthetic process|cell surface|enzyme binding|erythrocyte differentiation|negative regulation of ATPase activity|protein-containing complex|ATPase inhibitor activity|identical protein binding|protein homodimerization activity|angiostatin binding|ATPase binding|negative regulation of hydrolase activity|mitochondrial depolarization|reactive oxygen species metabolic process|mitochondrial proton-transporting ATP synthase complex binding|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of proteolysis involved in cellular protein catabolic process|regulation of protein targeting to mitochondrion|regulation of ATP metabolic process|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization ATP5MC1 1138.164493 1225.051854 1051.277132 0.858149089 -0.220699781 0.522908633 1 107.7162408 96.41838746 516 ATP synthase membrane subunit c locus 1 "GO:0000276,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0008289,GO:0015986,GO:0016021,GO:0042407,GO:0042776,GO:0045263,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|lipid binding|ATP synthesis coupled proton transport|integral component of membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5MC2 3824.99368 3819.279309 3830.708052 1.002992382 0.004310648 0.99012701 1 75.03220457 78.49848429 517 ATP synthase membrane subunit c locus 2 "GO:0000276,GO:0005515,GO:0005741,GO:0006754,GO:0008289,GO:0015986,GO:0016021,GO:0042407,GO:0042776,GO:0045263,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|mitochondrial outer membrane|ATP biosynthetic process|lipid binding|ATP synthesis coupled proton transport|integral component of membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5MC3 2347.072308 2470.402827 2223.741788 0.900153515 -0.151757031 0.635417423 1 45.07103319 42.31847658 518 ATP synthase membrane subunit c locus 3 "GO:0000276,GO:0005741,GO:0006754,GO:0008289,GO:0015986,GO:0016021,GO:0042407,GO:0042776,GO:0045263,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|mitochondrial outer membrane|ATP biosynthetic process|lipid binding|ATP synthesis coupled proton transport|integral component of membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5ME 777.7509579 867.787353 687.7145627 0.792492032 -0.335531665 0.364123197 1 145.0507197 119.9031857 521 ATP synthase membrane subunit e "GO:0000276,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0042407,GO:0042776,GO:0044877,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|cristae formation|mitochondrial ATP synthesis coupled proton transport|protein-containing complex binding|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714" Oxidative phosphorylation|Thermogenesis ATP5MF 434.2663047 691.1850145 177.347595 0.256584838 -1.962492173 7.79E-06 0.002101887 79.02050255 21.14884756 9551 ATP synthase membrane subunit f "GO:0005634,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0016021,GO:0031965,GO:0042407,GO:0042776,GO:0045263,GO:0046933,GO:1902600" "nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|integral component of membrane|nuclear membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting ATP synthase activity, rotational mechanism|proton transmembrane transport" "hsa00190,hsa04714" Oxidative phosphorylation|Thermogenesis ATP5MG 4171.431159 4399.834123 3943.028195 0.896176557 -0.158145107 0.620332462 1 198.7832976 185.8186924 10632 ATP synthase membrane subunit g "GO:0000276,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0015986,GO:0042407,GO:0042776,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|ATP synthesis coupled proton transport|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714" Oxidative phosphorylation|Thermogenesis ATP5MGL 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.19300603 0.260574036 267020 ATP synthase membrane subunit g like "GO:0000276,GO:0005739,GO:0015078,GO:0015986" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|mitochondrion|proton transmembrane transporter activity|ATP synthesis coupled proton transport" ATP5MJ 1089.73412 1079.91315 1099.555089 1.018188443 0.026004595 0.943080461 1 61.87080471 65.70975644 9556 ATP synthase membrane subunit j "GO:0003674,GO:0005575,GO:0005753,GO:0008150,GO:0016021" molecular_function|cellular_component|mitochondrial proton-transporting ATP synthase complex|biological_process|integral component of membrane ATP5MK 2856.857322 2834.77202 2878.942625 1.015581714 0.022306323 0.945265251 1 167.7233672 177.6742025 84833 ATP synthase membrane subunit k "GO:0005739,GO:0005753,GO:0016021" mitochondrion|mitochondrial proton-transporting ATP synthase complex|integral component of membrane ATP5PB 3043.368967 3225.530067 2861.207866 0.88705044 -0.172911953 0.587048956 1 62.16199351 57.51606674 515 ATP synthase peripheral stalk-membrane subunit b "GO:0000276,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0006754,GO:0015986,GO:0016020,GO:0021762,GO:0042407,GO:0042776,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|ATP biosynthetic process|ATP synthesis coupled proton transport|membrane|substantia nigra development|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5PD 2204.715207 2302.935092 2106.495323 0.914700258 -0.128629037 0.688781614 1 191.5197671 182.7293613 10476 ATP synthase peripheral stalk subunit d "GO:0000274,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0015986,GO:0042407,GO:0042776,GO:0044877,GO:0046933,GO:1901653" "mitochondrial proton-transporting ATP synthase, stator stalk|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|ATP synthesis coupled proton transport|cristae formation|mitochondrial ATP synthesis coupled proton transport|protein-containing complex binding|proton-transporting ATP synthase activity, rotational mechanism|cellular response to peptide" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5PF 1001.573243 1013.941012 989.2054742 0.975604559 -0.035631595 0.922287101 1 34.2122154 34.81536466 522 ATP synthase peripheral stalk subunit F6 "GO:0000276,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0021762,GO:0042407,GO:0042776,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|substantia nigra development|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5PO 2344.410708 2524.195493 2164.625923 0.857550823 -0.221705919 0.488108752 1 169.1026414 151.2607291 539 ATP synthase peripheral stalk subunit OSCP "GO:0000274,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005753,GO:0005886,GO:0006754,GO:0015986,GO:0042407,GO:0042776,GO:0045261,GO:0046933,GO:1902600" "mitochondrial proton-transporting ATP synthase, stator stalk|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|plasma membrane|ATP biosynthetic process|ATP synthesis coupled proton transport|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, catalytic core F(1)|proton-transporting ATP synthase activity, rotational mechanism|proton transmembrane transport" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP6AP1 4892.792677 5150.901539 4634.683815 0.899781093 -0.152354043 0.635026913 1 118.5795417 111.2916446 537 ATPase H+ transporting accessory protein 1 "GO:0005515,GO:0005524,GO:0005789,GO:0006879,GO:0008286,GO:0010008,GO:0016021,GO:0016469,GO:0030641,GO:0031267,GO:0033116,GO:0033180,GO:0033181,GO:0033572,GO:0034220,GO:0036295,GO:0045669,GO:0045780,GO:0045851,GO:0045921,GO:0051656,GO:0070062,GO:0070374,GO:1902600,GO:2001206" "protein binding|ATP binding|endoplasmic reticulum membrane|cellular iron ion homeostasis|insulin receptor signaling pathway|endosome membrane|integral component of membrane|proton-transporting two-sector ATPase complex|regulation of cellular pH|small GTPase binding|endoplasmic reticulum-Golgi intermediate compartment membrane|proton-transporting V-type ATPase, V1 domain|plasma membrane proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|positive regulation of osteoblast differentiation|positive regulation of bone resorption|pH reduction|positive regulation of exocytosis|establishment of organelle localization|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|proton transmembrane transport|positive regulation of osteoclast development" "hsa00190,hsa04142,hsa04145,hsa05110,hsa05120,hsa05152,hsa05161,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Hepatitis B|Human papillomavirus infection|Rheumatoid arthritis ATP6AP1L 83.63539017 93.37594909 73.89483124 0.791368998 -0.337577547 0.647318834 1 0.704163551 0.581257412 92270 ATPase H+ transporting accessory protein 1 like "GO:0016021,GO:0030641,GO:0033180,GO:0033181,GO:1902600" "integral component of membrane|regulation of cellular pH|proton-transporting V-type ATPase, V1 domain|plasma membrane proton-transporting V-type ATPase complex|proton transmembrane transport" ATP6AP2 4382.357416 4337.921809 4426.793024 1.020487049 0.029257873 0.927726771 1 97.99305814 104.308269 10159 ATPase H+ transporting accessory protein 2 "GO:0000421,GO:0002003,GO:0005515,GO:0005764,GO:0005765,GO:0005789,GO:0005886,GO:0007042,GO:0009897,GO:0010008,GO:0016021,GO:0016324,GO:0016471,GO:0021626,GO:0021903,GO:0030177,GO:0030424,GO:0032591,GO:0032914,GO:0038023,GO:0043312,GO:0043408,GO:0044297,GO:0045211,GO:0048069,GO:0060323,GO:0070062,GO:0070821,GO:0090263,GO:0101003" autophagosome membrane|angiotensin maturation|protein binding|lysosome|lysosomal membrane|endoplasmic reticulum membrane|plasma membrane|lysosomal lumen acidification|external side of plasma membrane|endosome membrane|integral component of membrane|apical plasma membrane|vacuolar proton-transporting V-type ATPase complex|central nervous system maturation|rostrocaudal neural tube patterning|positive regulation of Wnt signaling pathway|axon|dendritic spine membrane|positive regulation of transforming growth factor beta1 production|signaling receptor activity|neutrophil degranulation|regulation of MAPK cascade|cell body|postsynaptic membrane|eye pigmentation|head morphogenesis|extracellular exosome|tertiary granule membrane|positive regulation of canonical Wnt signaling pathway|ficolin-1-rich granule membrane hsa04614 Renin-angiotensin system ATP6V0A1 1013.879646 945.9389625 1081.820329 1.143647077 0.193641913 0.582790646 1 10.52008594 12.54952366 535 ATPase H+ transporting V0 subunit a1 "GO:0000220,GO:0005515,GO:0005765,GO:0005794,GO:0005829,GO:0005886,GO:0007035,GO:0008286,GO:0010008,GO:0016021,GO:0016241,GO:0016471,GO:0016607,GO:0030667,GO:0030670,GO:0033572,GO:0034220,GO:0042470,GO:0043231,GO:0043312,GO:0046961,GO:0048471,GO:0051117,GO:0070062,GO:0090383,GO:0101003,GO:1901998,GO:1902600" "vacuolar proton-transporting V-type ATPase, V0 domain|protein binding|lysosomal membrane|Golgi apparatus|cytosol|plasma membrane|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|integral component of membrane|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|nuclear speck|secretory granule membrane|phagocytic vesicle membrane|transferrin transport|ion transmembrane transport|melanosome|intracellular membrane-bounded organelle|neutrophil degranulation|proton-transporting ATPase activity, rotational mechanism|perinuclear region of cytoplasm|ATPase binding|extracellular exosome|phagosome acidification|ficolin-1-rich granule membrane|toxin transport|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0A2 415.8110293 372.4888404 459.1332181 1.232609325 0.301715611 0.483289069 1 5.987066234 7.697601805 23545 ATPase H+ transporting V0 subunit a2 "GO:0000220,GO:0001669,GO:0005515,GO:0005765,GO:0005886,GO:0006879,GO:0006955,GO:0007035,GO:0008286,GO:0010008,GO:0016021,GO:0016241,GO:0016471,GO:0030670,GO:0033572,GO:0034220,GO:0036295,GO:0046961,GO:0048471,GO:0051117,GO:0090383,GO:1902600" "vacuolar proton-transporting V-type ATPase, V0 domain|acrosomal vesicle|protein binding|lysosomal membrane|plasma membrane|cellular iron ion homeostasis|immune response|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|integral component of membrane|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|proton-transporting ATPase activity, rotational mechanism|perinuclear region of cytoplasm|ATPase binding|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0A4 59.22918799 75.10674166 43.35163433 0.577200307 -0.792856028 0.326429244 1 1.086515711 0.654151729 50617 ATPase H+ transporting V0 subunit a4 "GO:0000220,GO:0001503,GO:0005515,GO:0005765,GO:0005768,GO:0005886,GO:0006885,GO:0007035,GO:0007588,GO:0007605,GO:0008286,GO:0010008,GO:0016021,GO:0016324,GO:0016471,GO:0030670,GO:0031526,GO:0033572,GO:0034220,GO:0045177,GO:0046961,GO:0051117,GO:0070062,GO:0090383,GO:1902600" "vacuolar proton-transporting V-type ATPase, V0 domain|ossification|protein binding|lysosomal membrane|endosome|plasma membrane|regulation of pH|vacuolar acidification|excretion|sensory perception of sound|insulin receptor signaling pathway|endosome membrane|integral component of membrane|apical plasma membrane|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|brush border membrane|transferrin transport|ion transmembrane transport|apical part of cell|proton-transporting ATPase activity, rotational mechanism|ATPase binding|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0B 2211.371804 2320.189344 2102.554265 0.906199432 -0.142099509 0.657971213 1 119.057148 112.5369629 533 ATPase H+ transporting V0 subunit b "GO:0005215,GO:0005515,GO:0005774,GO:0008286,GO:0010008,GO:0016021,GO:0016241,GO:0030670,GO:0033179,GO:0033572,GO:0034220,GO:0046961,GO:0090383,GO:1902600" "transporter activity|protein binding|vacuolar membrane|insulin receptor signaling pathway|endosome membrane|integral component of membrane|regulation of macroautophagy|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0C 2424.804276 2463.298135 2386.310417 0.968746082 -0.045809525 0.887090245 1 109.0536368 110.1960538 527 ATPase H+ transporting V0 subunit c "GO:0005515,GO:0005765,GO:0005886,GO:0005925,GO:0008286,GO:0010008,GO:0015986,GO:0016021,GO:0016032,GO:0016241,GO:0030177,GO:0030670,GO:0031625,GO:0033179,GO:0033572,GO:0034220,GO:0035577,GO:0043312,GO:0046933,GO:0046961,GO:0070062,GO:0070821,GO:0090383,GO:0101003,GO:1902600" "protein binding|lysosomal membrane|plasma membrane|focal adhesion|insulin receptor signaling pathway|endosome membrane|ATP synthesis coupled proton transport|integral component of membrane|viral process|regulation of macroautophagy|positive regulation of Wnt signaling pathway|phagocytic vesicle membrane|ubiquitin protein ligase binding|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|azurophil granule membrane|neutrophil degranulation|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|tertiary granule membrane|phagosome acidification|ficolin-1-rich granule membrane|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0D1 1582.275523 1646.258581 1518.292466 0.922268521 -0.116741239 0.724185616 1 41.98247203 40.38697471 9114 ATPase H+ transporting V0 subunit d1 "GO:0005515,GO:0005765,GO:0005769,GO:0005813,GO:0006879,GO:0007034,GO:0007035,GO:0008286,GO:0010008,GO:0016020,GO:0016241,GO:0016471,GO:0030670,GO:0033179,GO:0033181,GO:0033572,GO:0034220,GO:0036295,GO:0036498,GO:0046961,GO:0060271,GO:0070062,GO:0090383,GO:1902600" "protein binding|lysosomal membrane|early endosome|centrosome|cellular iron ion homeostasis|vacuolar transport|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|membrane|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|plasma membrane proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|IRE1-mediated unfolded protein response|proton-transporting ATPase activity, rotational mechanism|cilium assembly|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05203,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Viral carcinogenesis|Rheumatoid arthritis ATP6V0E1 2450.668086 2547.539481 2353.796691 0.923949053 -0.114114792 0.721427121 1 90.92592496 87.62977209 8992 ATPase H+ transporting V0 subunit e1 "GO:0005515,GO:0007035,GO:0008286,GO:0010008,GO:0016021,GO:0016241,GO:0016787,GO:0030670,GO:0033179,GO:0033572,GO:0034220,GO:0042625,GO:0046961,GO:0055085,GO:0090383,GO:1902600" "protein binding|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|integral component of membrane|regulation of macroautophagy|hydrolase activity|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|ATPase-coupled ion transmembrane transporter activity|proton-transporting ATPase activity, rotational mechanism|transmembrane transport|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V0E2 1208.578486 1256.515489 1160.641483 0.923698508 -0.114506057 0.739072325 1 20.84444048 20.08336189 155066 ATPase H+ transporting V0 subunit e2 "GO:0007035,GO:0008286,GO:0010008,GO:0016021,GO:0016241,GO:0016787,GO:0030670,GO:0033179,GO:0033572,GO:0034220,GO:0042625,GO:0046961,GO:0055085,GO:0090383,GO:1902600" "vacuolar acidification|insulin receptor signaling pathway|endosome membrane|integral component of membrane|regulation of macroautophagy|hydrolase activity|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|ATPase-coupled ion transmembrane transporter activity|proton-transporting ATPase activity, rotational mechanism|transmembrane transport|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1A 1928.80356 2030.926893 1826.680228 0.899431799 -0.152914205 0.636702511 1 22.48290326 21.0929129 523 ATPase H+ transporting V1 subunit A "GO:0005524,GO:0005654,GO:0005765,GO:0005774,GO:0005829,GO:0005886,GO:0005902,GO:0006879,GO:0008286,GO:0015986,GO:0016241,GO:0016324,GO:0016469,GO:0033180,GO:0033572,GO:0034220,GO:0036295,GO:0043231,GO:0046933,GO:0046961,GO:0070062,GO:0090383" "ATP binding|nucleoplasm|lysosomal membrane|vacuolar membrane|cytosol|plasma membrane|microvillus|cellular iron ion homeostasis|insulin receptor signaling pathway|ATP synthesis coupled proton transport|regulation of macroautophagy|apical plasma membrane|proton-transporting two-sector ATPase complex|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|intracellular membrane-bounded organelle|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1B1 15.4942851 15.22433953 15.76423066 1.035462369 0.050275123 1 1 0.323974407 0.349913706 525 ATPase H+ transporting V1 subunit B1 "GO:0001503,GO:0003091,GO:0003096,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005902,GO:0006693,GO:0006885,GO:0007588,GO:0007605,GO:0008286,GO:0010468,GO:0015078,GO:0016241,GO:0016323,GO:0016324,GO:0016328,GO:0016471,GO:0016787,GO:0030534,GO:0033180,GO:0033572,GO:0034220,GO:0035812,GO:0042048,GO:0042472,GO:0044877,GO:0045851,GO:0046034,GO:0055064,GO:0055074,GO:0055075,GO:0070062,GO:0090383,GO:0098850,GO:1902600" "ossification|renal water homeostasis|renal sodium ion transport|protein binding|ATP binding|cytoplasm|cytosol|microvillus|prostaglandin metabolic process|regulation of pH|excretion|sensory perception of sound|insulin receptor signaling pathway|regulation of gene expression|proton transmembrane transporter activity|regulation of macroautophagy|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|vacuolar proton-transporting V-type ATPase complex|hydrolase activity|adult behavior|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|renal sodium excretion|olfactory behavior|inner ear morphogenesis|protein-containing complex binding|pH reduction|ATP metabolic process|chloride ion homeostasis|calcium ion homeostasis|potassium ion homeostasis|extracellular exosome|phagosome acidification|extrinsic component of synaptic vesicle membrane|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1B2 1470.77066 1533.598468 1407.942851 0.918064852 -0.123332025 0.711745409 1 27.19585161 26.04305653 526 ATPase H+ transporting V1 subunit B2 "GO:0001726,GO:0005515,GO:0005524,GO:0005765,GO:0005829,GO:0005886,GO:0005902,GO:0008286,GO:0012505,GO:0015078,GO:0016021,GO:0016241,GO:0016324,GO:0016787,GO:0033180,GO:0033572,GO:0034220,GO:0042470,GO:0043231,GO:0046034,GO:0046961,GO:0070062,GO:0090383,GO:1902600" "ruffle|protein binding|ATP binding|lysosomal membrane|cytosol|plasma membrane|microvillus|insulin receptor signaling pathway|endomembrane system|proton transmembrane transporter activity|integral component of membrane|regulation of macroautophagy|apical plasma membrane|hydrolase activity|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|melanosome|intracellular membrane-bounded organelle|ATP metabolic process|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1C1 2704.15074 2902.77407 2505.527411 0.863149302 -0.212317966 0.505304398 1 26.08966571 23.48931585 528 ATPase H+ transporting V1 subunit C1 "GO:0000221,GO:0005215,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0008286,GO:0016241,GO:0016469,GO:0031410,GO:0033572,GO:0034220,GO:0045177,GO:0046961,GO:0070062,GO:0090383,GO:1902600" "vacuolar proton-transporting V-type ATPase, V1 domain|transporter activity|protein binding|lysosomal membrane|cytosol|plasma membrane|insulin receptor signaling pathway|regulation of macroautophagy|proton-transporting two-sector ATPase complex|cytoplasmic vesicle|transferrin transport|ion transmembrane transport|apical part of cell|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1D 1382.047128 1227.081766 1537.01249 1.252575446 0.324897503 0.3324207 1 38.86639309 50.78015971 51382 ATPase H+ transporting V1 subunit D "GO:0005515,GO:0005765,GO:0005813,GO:0005829,GO:0005886,GO:0005929,GO:0008286,GO:0016020,GO:0016241,GO:0033176,GO:0033572,GO:0034220,GO:0035579,GO:0043312,GO:0046961,GO:0060271,GO:0061512,GO:0070062,GO:0090383,GO:1902600" "protein binding|lysosomal membrane|centrosome|cytosol|plasma membrane|cilium|insulin receptor signaling pathway|membrane|regulation of macroautophagy|proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|specific granule membrane|neutrophil degranulation|proton-transporting ATPase activity, rotational mechanism|cilium assembly|protein localization to cilium|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1E1 2308.253086 2174.035684 2442.470489 1.123473044 0.16796551 0.599860945 1 82.60107867 96.79753663 529 ATPase H+ transporting V1 subunit E1 "GO:0005515,GO:0005765,GO:0005768,GO:0005829,GO:0005902,GO:0008286,GO:0008553,GO:0016241,GO:0016324,GO:0016469,GO:0016787,GO:0033178,GO:0033572,GO:0034220,GO:0046961,GO:0051117,GO:0070062,GO:0090383,GO:1902600" "protein binding|lysosomal membrane|endosome|cytosol|microvillus|insulin receptor signaling pathway|proton-exporting ATPase activity, phosphorylative mechanism|regulation of macroautophagy|apical plasma membrane|proton-transporting two-sector ATPase complex|hydrolase activity|proton-transporting two-sector ATPase complex, catalytic domain|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|ATPase binding|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1E2 32.43677526 28.41876711 36.45478341 1.282771461 0.359264162 0.731077512 1 0.45461475 0.608287289 90423 ATPase H+ transporting V1 subunit E2 "GO:0001669,GO:0005515,GO:0005829,GO:0008286,GO:0008553,GO:0016241,GO:0033178,GO:0033572,GO:0034220,GO:0046961,GO:0090383,GO:1902600" "acrosomal vesicle|protein binding|cytosol|insulin receptor signaling pathway|proton-exporting ATPase activity, phosphorylative mechanism|regulation of macroautophagy|proton-transporting two-sector ATPase complex, catalytic domain|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1F 2102.326142 2072.540087 2132.112197 1.028743526 0.040883352 0.900119041 1 137.7517637 147.8155804 9296 ATPase H+ transporting V1 subunit F "GO:0005515,GO:0005829,GO:0008286,GO:0015078,GO:0016020,GO:0016469,GO:0016471,GO:0016887,GO:0033180,GO:0033572,GO:0034220,GO:0042625,GO:0046961,GO:0070062,GO:0090383,GO:1902600" "protein binding|cytosol|insulin receptor signaling pathway|proton transmembrane transporter activity|membrane|proton-transporting two-sector ATPase complex|vacuolar proton-transporting V-type ATPase complex|ATPase activity|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|ATPase-coupled ion transmembrane transporter activity|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1FNB 12.44941719 9.134603715 15.76423066 1.725770614 0.787240717 0.570104177 1 0.11914382 0.21447196 100130705 ATP6V1F neighbor ATP6V1G1 1286.948823 1293.053904 1280.843742 0.990557113 -0.013687936 0.970256058 1 41.89930813 43.29146693 9550 ATPase H+ transporting V1 subunit G1 "GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0006879,GO:0008286,GO:0016241,GO:0016471,GO:0016887,GO:0033572,GO:0034220,GO:0036295,GO:0046961,GO:0051117,GO:0070062,GO:0090383,GO:1902600" "protein binding|lysosomal membrane|cytosol|plasma membrane|cellular iron ion homeostasis|insulin receptor signaling pathway|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|ATPase activity|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|proton-transporting ATPase activity, rotational mechanism|ATPase binding|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1G2 15.47943932 14.20938356 16.74949508 1.178762964 0.237273638 0.895884728 1 0.485925152 0.597464067 534 ATPase H+ transporting V1 subunit G2 "GO:0005515,GO:0005829,GO:0008286,GO:0016241,GO:0016471,GO:0033572,GO:0034220,GO:0042470,GO:0042626,GO:0090383,GO:1902600" protein binding|cytosol|insulin receptor signaling pathway|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|melanosome|ATPase-coupled transmembrane transporter activity|phagosome acidification|proton transmembrane transport "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1H 1969.838016 1704.111071 2235.564961 1.311865758 0.391620097 0.224963192 1 36.82048379 50.38425211 51606 ATPase H+ transporting V1 subunit H "GO:0000221,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0006897,GO:0007035,GO:0008286,GO:0016241,GO:0016887,GO:0030234,GO:0033572,GO:0034220,GO:0046961,GO:0050690,GO:0050790,GO:0070062,GO:0090383,GO:1902600" "vacuolar proton-transporting V-type ATPase, V1 domain|protein binding|lysosomal membrane|cytosol|plasma membrane|endocytosis|vacuolar acidification|insulin receptor signaling pathway|regulation of macroautophagy|ATPase activity|enzyme regulator activity|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|regulation of defense response to virus by virus|regulation of catalytic activity|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04150,hsa04721,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP7A 497.0169093 602.8838452 391.1499734 0.648798233 -0.624158205 0.127517349 1 3.595612331 2.433315649 538 ATPase copper transporting alpha "GO:0001568,GO:0001701,GO:0001889,GO:0001974,GO:0002082,GO:0005375,GO:0005507,GO:0005515,GO:0005524,GO:0005634,GO:0005770,GO:0005783,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005902,GO:0006568,GO:0006584,GO:0006825,GO:0006878,GO:0007005,GO:0007565,GO:0007595,GO:0007626,GO:0010041,GO:0010042,GO:0010043,GO:0010273,GO:0010468,GO:0010592,GO:0015677,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016532,GO:0018205,GO:0019430,GO:0019730,GO:0021702,GO:0021860,GO:0021954,GO:0030140,GO:0030141,GO:0030198,GO:0030199,GO:0030670,GO:0031069,GO:0031252,GO:0031526,GO:0032767,GO:0034220,GO:0034760,GO:0036120,GO:0042093,GO:0042414,GO:0042415,GO:0042417,GO:0042428,GO:0043005,GO:0043025,GO:0043085,GO:0043204,GO:0043473,GO:0043588,GO:0043682,GO:0045121,GO:0045793,GO:0048251,GO:0048286,GO:0048471,GO:0048812,GO:0050679,GO:0051087,GO:0051216,GO:0051353,GO:0051542,GO:0060003,GO:0071230,GO:0071236,GO:0071276,GO:0071279,GO:0071280,GO:0071281,GO:0071284,GO:0071456,GO:0072511,GO:1903036,GO:1903136,GO:1904754,GO:1904959" "blood vessel development|in utero embryonic development|liver development|blood vessel remodeling|regulation of oxidative phosphorylation|copper ion transmembrane transporter activity|copper ion binding|protein binding|ATP binding|nucleus|late endosome|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|microvillus|tryptophan metabolic process|catecholamine metabolic process|copper ion transport|cellular copper ion homeostasis|mitochondrion organization|female pregnancy|lactation|locomotory behavior|response to iron(III) ion|response to manganese ion|response to zinc ion|detoxification of copper ion|regulation of gene expression|positive regulation of lamellipodium assembly|copper ion import|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|superoxide dismutase copper chaperone activity|peptidyl-lysine modification|removal of superoxide radicals|antimicrobial humoral response|cerebellar Purkinje cell differentiation|pyramidal neuron development|central nervous system neuron development|trans-Golgi network transport vesicle|secretory granule|extracellular matrix organization|collagen fibril organization|phagocytic vesicle membrane|hair follicle morphogenesis|cell leading edge|brush border membrane|copper-dependent protein binding|ion transmembrane transport|negative regulation of iron ion transmembrane transport|cellular response to platelet-derived growth factor stimulus|T-helper cell differentiation|epinephrine metabolic process|norepinephrine metabolic process|dopamine metabolic process|serotonin metabolic process|neuron projection|neuronal cell body|positive regulation of catalytic activity|perikaryon|pigmentation|skin development|copper transmembrane transporter activity, phosphorylative mechanism|membrane raft|positive regulation of cell size|elastic fiber assembly|lung alveolus development|perinuclear region of cytoplasm|neuron projection morphogenesis|positive regulation of epithelial cell proliferation|chaperone binding|cartilage development|positive regulation of oxidoreductase activity|elastin biosynthetic process|copper ion export|cellular response to amino acid stimulus|cellular response to antibiotic|cellular response to cadmium ion|cellular response to cobalt ion|cellular response to copper ion|cellular response to iron ion|cellular response to lead ion|cellular response to hypoxia|divalent inorganic cation transport|positive regulation of response to wounding|cuprous ion binding|positive regulation of vascular associated smooth muscle cell migration|regulation of cytochrome-c oxidase activity" "hsa01524,hsa04978" Platinum drug resistance|Mineral absorption ATP7B 407.6886599 389.7430919 425.6342279 1.092089217 0.12709072 0.772490524 1 1.588405301 1.809403293 540 ATPase copper transporting beta "GO:0000139,GO:0005375,GO:0005507,GO:0005515,GO:0005524,GO:0005739,GO:0005770,GO:0005794,GO:0005802,GO:0005887,GO:0006825,GO:0006878,GO:0015677,GO:0016020,GO:0016323,GO:0031410,GO:0032588,GO:0034220,GO:0043682,GO:0046688,GO:0048471,GO:0051208,GO:0060003,GO:0072511" "Golgi membrane|copper ion transmembrane transporter activity|copper ion binding|protein binding|ATP binding|mitochondrion|late endosome|Golgi apparatus|trans-Golgi network|integral component of plasma membrane|copper ion transport|cellular copper ion homeostasis|copper ion import|membrane|basolateral plasma membrane|cytoplasmic vesicle|trans-Golgi network membrane|ion transmembrane transport|copper transmembrane transporter activity, phosphorylative mechanism|response to copper ion|perinuclear region of cytoplasm|sequestering of calcium ion|copper ion export|divalent inorganic cation transport" "hsa01524,hsa04978" Platinum drug resistance|Mineral absorption ATP8A1 141.1315817 184.7219862 97.54117724 0.528043138 -0.921272301 0.128438587 1 1.121899142 0.617929813 10396 ATPase phospholipid transporting 8A1 "GO:0000287,GO:0005515,GO:0005524,GO:0005783,GO:0005794,GO:0005802,GO:0005886,GO:0006869,GO:0007612,GO:0016020,GO:0016021,GO:0016887,GO:0019829,GO:0022857,GO:0030335,GO:0031090,GO:0031410,GO:0034220,GO:0035577,GO:0035579,GO:0042584,GO:0043231,GO:0043312,GO:0045332,GO:0055085,GO:0061092,GO:0070062,GO:0098655,GO:0140326,GO:0140327,GO:0140331,GO:0140346,GO:0150104,GO:1990531" magnesium ion binding|protein binding|ATP binding|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|plasma membrane|lipid transport|learning|membrane|integral component of membrane|ATPase activity|ATPase-coupled cation transmembrane transporter activity|transmembrane transporter activity|positive regulation of cell migration|organelle membrane|cytoplasmic vesicle|ion transmembrane transport|azurophil granule membrane|specific granule membrane|chromaffin granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|phospholipid translocation|transmembrane transport|positive regulation of phospholipid translocation|extracellular exosome|cation transmembrane transport|ATPase-coupled intramembrane lipid transporter activity|flippase activity|aminophospholipid translocation|phosphatidylserine flippase activity|transport across blood-brain barrier|phospholipid-translocating ATPase complex ATP8A2 13.53860204 16.23929549 10.83790858 0.667387855 -0.583402663 0.677251882 1 0.042816546 0.029806148 51761 ATPase phospholipid transporting 8A2 "GO:0000287,GO:0001750,GO:0003011,GO:0005515,GO:0005524,GO:0005654,GO:0005768,GO:0005794,GO:0005886,GO:0007409,GO:0007568,GO:0008285,GO:0010842,GO:0010976,GO:0010996,GO:0016021,GO:0016887,GO:0040018,GO:0042472,GO:0042755,GO:0043588,GO:0045332,GO:0048666,GO:0050884,GO:0050908,GO:0060052,GO:0061092,GO:0090555,GO:0140326,GO:0140331,GO:0140346" magnesium ion binding|photoreceptor outer segment|involuntary skeletal muscle contraction|protein binding|ATP binding|nucleoplasm|endosome|Golgi apparatus|plasma membrane|axonogenesis|aging|negative regulation of cell population proliferation|retina layer formation|positive regulation of neuron projection development|response to auditory stimulus|integral component of membrane|ATPase activity|positive regulation of multicellular organism growth|inner ear morphogenesis|eating behavior|skin development|phospholipid translocation|neuron development|neuromuscular process controlling posture|detection of light stimulus involved in visual perception|neurofilament cytoskeleton organization|positive regulation of phospholipid translocation|phosphatidylethanolamine flippase activity|ATPase-coupled intramembrane lipid transporter activity|aminophospholipid translocation|phosphatidylserine flippase activity ATP8B1 910.7047465 1200.692911 620.7165824 0.51696531 -0.951860621 0.008283431 0.378025688 9.870290558 5.322397035 5205 ATPase phospholipid transporting 8B1 "GO:0000287,GO:0005515,GO:0005524,GO:0005654,GO:0005783,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0006855,GO:0007030,GO:0007605,GO:0008206,GO:0015721,GO:0016324,GO:0016604,GO:0021650,GO:0031526,GO:0032420,GO:0032534,GO:0034220,GO:0045176,GO:0045332,GO:0045892,GO:0060119,GO:0140326,GO:0140331,GO:0140345,GO:0140346,GO:1901612,GO:1903729,GO:1990531,GO:2001225" "magnesium ion binding|protein binding|ATP binding|nucleoplasm|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|integral component of plasma membrane|drug transmembrane transport|Golgi organization|sensory perception of sound|bile acid metabolic process|bile acid and bile salt transport|apical plasma membrane|nuclear body|vestibulocochlear nerve formation|brush border membrane|stereocilium|regulation of microvillus assembly|ion transmembrane transport|apical protein localization|phospholipid translocation|negative regulation of transcription, DNA-templated|inner ear receptor cell development|ATPase-coupled intramembrane lipid transporter activity|aminophospholipid translocation|phosphatidylcholine flippase activity|phosphatidylserine flippase activity|cardiolipin binding|regulation of plasma membrane organization|phospholipid-translocating ATPase complex|regulation of chloride transport" ATP8B2 2166.646194 2327.294035 2005.998352 0.861944525 -0.214333075 0.504180111 1 18.45166448 16.5894044 57198 ATPase phospholipid transporting 8B2 "GO:0000287,GO:0005524,GO:0005789,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0007030,GO:0034220,GO:0045332,GO:0140326,GO:0140345" magnesium ion binding|ATP binding|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|Golgi organization|ion transmembrane transport|phospholipid translocation|ATPase-coupled intramembrane lipid transporter activity|phosphatidylcholine flippase activity ATP8B3 164.6443158 175.5873825 153.701249 0.875354748 -0.19206029 0.745455063 1 1.65448958 1.510650705 148229 ATPase phospholipid transporting 8B3 "GO:0000287,GO:0002080,GO:0005524,GO:0005789,GO:0005802,GO:0005886,GO:0007030,GO:0007339,GO:0016021,GO:0045332,GO:0140326" magnesium ion binding|acrosomal membrane|ATP binding|endoplasmic reticulum membrane|trans-Golgi network|plasma membrane|Golgi organization|binding of sperm to zona pellucida|integral component of membrane|phospholipid translocation|ATPase-coupled intramembrane lipid transporter activity ATP9A 6561.071242 6412.491808 6709.650677 1.046340623 0.06535258 0.841520284 1 40.59118712 44.30173851 10079 ATPase phospholipid transporting 9A (putative) "GO:0000287,GO:0002020,GO:0005524,GO:0005768,GO:0005769,GO:0005802,GO:0005886,GO:0006890,GO:0006897,GO:0016021,GO:0031901,GO:0045332,GO:0048471,GO:0055037,GO:0140326" "magnesium ion binding|protease binding|ATP binding|endosome|early endosome|trans-Golgi network|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|endocytosis|integral component of membrane|early endosome membrane|phospholipid translocation|perinuclear region of cytoplasm|recycling endosome|ATPase-coupled intramembrane lipid transporter activity" ATP9B 372.1273446 417.146903 327.1077863 0.784154896 -0.350789434 0.429344193 1 1.73058806 1.415505271 374868 ATPase phospholipid transporting 9B (putative) "GO:0000287,GO:0005524,GO:0005768,GO:0005802,GO:0005886,GO:0006890,GO:0006897,GO:0016021,GO:0045332,GO:0048471,GO:0140326" "magnesium ion binding|ATP binding|endosome|trans-Golgi network|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|endocytosis|integral component of membrane|phospholipid translocation|perinuclear region of cytoplasm|ATPase-coupled intramembrane lipid transporter activity" ATPAF1 958.3336942 920.5650633 996.1023251 1.082055321 0.11377426 0.750602898 1 10.46775323 11.81459587 64756 ATP synthase mitochondrial F1 complex assembly factor 1 "GO:0005515,GO:0005739,GO:0033615" protein binding|mitochondrion|mitochondrial proton-transporting ATP synthase complex assembly ATPAF2 282.0756116 289.262451 274.8887722 0.950309213 -0.073531078 0.885788738 1 4.84461729 4.802201116 91647 ATP synthase mitochondrial F1 complex assembly factor 2 "GO:0005515,GO:0005739,GO:0005829,GO:0016607,GO:0043461" protein binding|mitochondrion|cytosol|nuclear speck|proton-transporting ATP synthase complex assembly ATPSCKMT 473.4920511 577.509946 369.4741562 0.63977107 -0.644372338 0.120226812 1 10.96694467 7.318569138 134145 ATP synthase c subunit lysine N-methyltransferase "GO:0005515,GO:0005739,GO:0016021,GO:0016279,GO:0018022,GO:0018023,GO:0030061,GO:1904058,GO:1905273,GO:1905706" "protein binding|mitochondrion|integral component of membrane|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|peptidyl-lysine trimethylation|mitochondrial crista|positive regulation of sensory perception of pain|positive regulation of proton-transporting ATP synthase activity, rotational mechanism|regulation of mitochondrial ATP synthesis coupled proton transport" ATR 824.9963909 898.236032 751.7567498 0.836925622 -0.256828679 0.482562748 1 5.576426359 4.868091862 545 ATR serine/threonine kinase "GO:0000077,GO:0000723,GO:0000781,GO:0003677,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005794,GO:0006260,GO:0006281,GO:0006974,GO:0007275,GO:0008156,GO:0016605,GO:0018105,GO:0031297,GO:0032212,GO:0032405,GO:0032407,GO:0034644,GO:0036297,GO:0042493,GO:0043517,GO:0046777,GO:0070198,GO:0071480,GO:0090399,GO:0097694,GO:0097695,GO:0106310,GO:0106311,GO:1900034,GO:1901796,GO:1904884" "DNA damage checkpoint|telomere maintenance|chromosome, telomeric region|DNA binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|Golgi apparatus|DNA replication|DNA repair|cellular response to DNA damage stimulus|multicellular organism development|negative regulation of DNA replication|PML body|peptidyl-serine phosphorylation|replication fork processing|positive regulation of telomere maintenance via telomerase|MutLalpha complex binding|MutSalpha complex binding|cellular response to UV|interstrand cross-link repair|response to drug|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|protein localization to chromosome, telomeric region|cellular response to gamma radiation|replicative senescence|establishment of RNA localization to telomere|establishment of protein-containing complex localization to telomere|protein serine kinase activity|protein threonine kinase activity|regulation of cellular response to heat|regulation of signal transduction by p53 class mediator|positive regulation of telomerase catalytic core complex assembly" "hsa03460,hsa04110,hsa04115,hsa04218,hsa05165,hsa05166,hsa05170" Fanconi anemia pathway|Cell cycle|p53 signaling pathway|Cellular senescence|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection ATRAID 1268.037041 1448.342167 1087.731916 0.751018606 -0.413079444 0.223446699 1 52.6585939 41.25113333 51374 all-trans retinoic acid induced differentiation factor "GO:0003674,GO:0005515,GO:0005635,GO:0005765,GO:0005886,GO:0010468,GO:0016021,GO:0030154,GO:0030501,GO:0033689,GO:0045669,GO:0048471,GO:1903363" molecular_function|protein binding|nuclear envelope|lysosomal membrane|plasma membrane|regulation of gene expression|integral component of membrane|cell differentiation|positive regulation of bone mineralization|negative regulation of osteoblast proliferation|positive regulation of osteoblast differentiation|perinuclear region of cytoplasm|negative regulation of cellular protein catabolic process ATRIP 351.0386776 356.2495449 345.8278102 0.970745971 -0.042834281 0.930774968 1 3.788113096 3.835698501 84126 ATR interacting protein "GO:0000077,GO:0005515,GO:0005654,GO:0006260,GO:0006281,GO:0036297,GO:0070530,GO:1901796" DNA damage checkpoint|protein binding|nucleoplasm|DNA replication|DNA repair|interstrand cross-link repair|K63-linked polyubiquitin modification-dependent protein binding|regulation of signal transduction by p53 class mediator hsa03460 Fanconi anemia pathway ATRN 5915.157918 5834.981862 5995.333975 1.027481167 0.039111951 0.904403857 1 33.21209786 35.59476328 8455 attractin "GO:0005604,GO:0005615,GO:0005737,GO:0005886,GO:0005887,GO:0006954,GO:0006979,GO:0009887,GO:0009888,GO:0016477,GO:0021549,GO:0030246,GO:0034446,GO:0038023,GO:0040014,GO:0042552,GO:0043473,GO:0070062" basement membrane|extracellular space|cytoplasm|plasma membrane|integral component of plasma membrane|inflammatory response|response to oxidative stress|animal organ morphogenesis|tissue development|cell migration|cerebellum development|carbohydrate binding|substrate adhesion-dependent cell spreading|signaling receptor activity|regulation of multicellular organism growth|myelination|pigmentation|extracellular exosome ATRNL1 213.3379539 204.0061496 222.6697581 1.091485519 0.12629299 0.818265282 1 0.416402361 0.474075041 26033 attractin like 1 "GO:0005604,GO:0007186,GO:0009887,GO:0009888,GO:0016021,GO:0016477,GO:0030246,GO:0034446" basement membrane|G protein-coupled receptor signaling pathway|animal organ morphogenesis|tissue development|integral component of membrane|cell migration|carbohydrate binding|substrate adhesion-dependent cell spreading ATRX 2965.681782 2865.220699 3066.142864 1.070124499 0.09777865 0.75926199 1 12.53678795 13.99382751 546 ATRX chromatin remodeler "GO:0000212,GO:0000228,GO:0000779,GO:0000781,GO:0000792,GO:0003677,GO:0003678,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005721,GO:0006281,GO:0006306,GO:0006334,GO:0006336,GO:0006338,GO:0006355,GO:0007283,GO:0010571,GO:0015616,GO:0016604,GO:0016605,GO:0030330,GO:0030900,GO:0031297,GO:0032206,GO:0032508,GO:0035064,GO:0035128,GO:0035264,GO:0042393,GO:0045944,GO:0046872,GO:0060009,GO:0070087,GO:0070192,GO:0070198,GO:0072520,GO:0072711,GO:0099115,GO:1900112,GO:1901581,GO:1901582,GO:1904908" "meiotic spindle organization|nuclear chromosome|condensed chromosome, centromeric region|chromosome, telomeric region|heterochromatin|DNA binding|DNA helicase activity|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|pericentric heterochromatin|DNA repair|DNA methylation|nucleosome assembly|DNA replication-independent nucleosome assembly|chromatin remodeling|regulation of transcription, DNA-templated|spermatogenesis|positive regulation of nuclear cell cycle DNA replication|DNA translocase activity|nuclear body|PML body|DNA damage response, signal transduction by p53 class mediator|forebrain development|replication fork processing|positive regulation of telomere maintenance|DNA duplex unwinding|methylated histone binding|post-embryonic forelimb morphogenesis|multicellular organism growth|histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding|Sertoli cell development|chromo shadow domain binding|chromosome organization involved in meiotic cell cycle|protein localization to chromosome, telomeric region|seminiferous tubule development|cellular response to hydroxyurea|chromosome, subtelomeric region|regulation of histone H3-K9 trimethylation|negative regulation of telomeric RNA transcription from RNA pol II promoter|positive regulation of telomeric RNA transcription from RNA pol II promoter|negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric" other ATXN1 393.8437398 285.2026271 502.4848524 1.761852117 0.817092835 0.061395764 1 1.361918436 2.50285956 6310 ataxin 1 "GO:0000122,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006355,GO:0006396,GO:0007399,GO:0007420,GO:0007612,GO:0007613,GO:0008022,GO:0008266,GO:0016363,GO:0034046,GO:0035176,GO:0042405,GO:0042802,GO:0043621,GO:0045892,GO:0048856,GO:0051168" "negative regulation of transcription by RNA polymerase II|DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of transcription, DNA-templated|RNA processing|nervous system development|brain development|learning|memory|protein C-terminus binding|poly(U) RNA binding|nuclear matrix|poly(G) binding|social behavior|nuclear inclusion body|identical protein binding|protein self-association|negative regulation of transcription, DNA-templated|anatomical structure development|nuclear export" "hsa04330,hsa05017,hsa05022" Notch signaling pathway|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATXN10 1696.320498 1730.499926 1662.141071 0.960497626 -0.058146047 0.860395418 1 26.60707845 26.65688606 25814 ataxin 10 "GO:0005515,GO:0005615,GO:0005737,GO:0005829,GO:0005886,GO:0007399,GO:0016020,GO:0019899,GO:0030425,GO:0031175,GO:0042802,GO:0043025,GO:0048471,GO:0060271" protein binding|extracellular space|cytoplasm|cytosol|plasma membrane|nervous system development|membrane|enzyme binding|dendrite|neuron projection development|identical protein binding|neuronal cell body|perinuclear region of cytoplasm|cilium assembly hsa05017 Spinocerebellar ataxia ATXN1L 1284.580179 1232.156546 1337.003813 1.085092489 0.117818018 0.729275229 1 7.903290558 8.945211962 342371 ataxin 1 like "GO:0000122,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006355,GO:0007420,GO:0007612,GO:0007613,GO:0030198,GO:0030425,GO:0035176,GO:0048286,GO:0048856,GO:1902035" "negative regulation of transcription by RNA polymerase II|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|brain development|learning|memory|extracellular matrix organization|dendrite|social behavior|lung alveolus development|anatomical structure development|positive regulation of hematopoietic stem cell proliferation" "hsa04330,hsa05017,hsa05022" Notch signaling pathway|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATXN2 1419.452041 1292.038948 1546.865134 1.197227945 0.259697859 0.437010814 1 14.47405766 18.07519841 6311 ataxin 2 "GO:0002091,GO:0003723,GO:0005154,GO:0005515,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0005844,GO:0006417,GO:0008022,GO:0010494,GO:0010603,GO:0016020,GO:0016070,GO:0033962,GO:0034063,GO:0048471,GO:0050658,GO:1990904" negative regulation of receptor internalization|RNA binding|epidermal growth factor receptor binding|protein binding|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|polysome|regulation of translation|protein C-terminus binding|cytoplasmic stress granule|regulation of cytoplasmic mRNA processing body assembly|membrane|RNA metabolic process|P-body assembly|stress granule assembly|perinuclear region of cytoplasm|RNA transport|ribonucleoprotein complex "hsa05014,hsa05017,hsa05022" Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATXN2L 3199.078847 2756.62041 3641.537284 1.321015135 0.401646996 0.206944264 1 28.80996678 39.69780377 11273 ataxin 2 like "GO:0003723,GO:0005515,GO:0005829,GO:0010494,GO:0010603,GO:0016020,GO:0016607,GO:0034063,GO:0045296" RNA binding|protein binding|cytosol|cytoplasmic stress granule|regulation of cytoplasmic mRNA processing body assembly|membrane|nuclear speck|stress granule assembly|cadherin binding "hsa05014,hsa05017,hsa05022" Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATXN3 345.7115195 328.8457338 362.5773053 1.10257567 0.140877672 0.760224442 1 2.419360302 2.782434085 4287 ataxin 3 "GO:0000226,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005759,GO:0005789,GO:0005829,GO:0005886,GO:0006289,GO:0006511,GO:0006515,GO:0007268,GO:0007399,GO:0008234,GO:0010810,GO:0016363,GO:0016579,GO:0018215,GO:0030036,GO:0031625,GO:0031966,GO:0034605,GO:0035520,GO:0042405,GO:0043161,GO:0045104,GO:0045202,GO:0051117,GO:0061578,GO:0070536,GO:0071108,GO:0071218,GO:1904294,GO:1904379,GO:1990380" microtubule cytoskeleton organization|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrial matrix|endoplasmic reticulum membrane|cytosol|plasma membrane|nucleotide-excision repair|ubiquitin-dependent protein catabolic process|protein quality control for misfolded or incompletely synthesized proteins|chemical synaptic transmission|nervous system development|cysteine-type peptidase activity|regulation of cell-substrate adhesion|nuclear matrix|protein deubiquitination|protein phosphopantetheinylation|actin cytoskeleton organization|ubiquitin protein ligase binding|mitochondrial membrane|cellular response to heat|monoubiquitinated protein deubiquitination|nuclear inclusion body|proteasome-mediated ubiquitin-dependent protein catabolic process|intermediate filament cytoskeleton organization|synapse|ATPase binding|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|cellular response to misfolded protein|positive regulation of ERAD pathway|protein localization to cytosolic proteasome complex involved in ERAD pathway|Lys48-specific deubiquitinase activity "hsa04141,hsa05017,hsa05022" Protein processing in endoplasmic reticulum|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATXN7 1052.771858 1078.898194 1026.645522 0.951568487 -0.071620601 0.839841894 1 6.951073327 6.899344814 6314 ataxin 7 "GO:0000226,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006997,GO:0007026,GO:0007601,GO:0015630,GO:0016363,GO:0016578,GO:0016579" microtubule cytoskeleton organization|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|nucleus organization|negative regulation of microtubule depolymerization|visual perception|microtubule cytoskeleton|nuclear matrix|histone deubiquitination|protein deubiquitination ATXN7L1 147.0904272 154.2733072 139.9075471 0.906881104 -0.141014675 0.822560361 1 0.484942823 0.458729658 222255 ataxin 7 like 1 GO:0005515 protein binding ATXN7L2 92.06952081 97.43577296 86.70326866 0.889850473 -0.168365163 0.821985371 1 1.208911849 1.122089761 127002 ataxin 7 like 2 ATXN7L3 2928.137813 2858.116007 2998.15962 1.048998575 0.069012719 0.829132621 1 30.22624617 33.0731106 56970 ataxin 7 like 3 "GO:0000124,GO:0003713,GO:0005515,GO:0005634,GO:0006357,GO:0008270,GO:0010390,GO:0016578,GO:0030374,GO:0045893,GO:0071819" "SAGA complex|transcription coactivator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|histone monoubiquitination|histone deubiquitination|nuclear receptor coactivator activity|positive regulation of transcription, DNA-templated|DUBm complex" ATXN7L3B 2170.673851 1996.41839 2344.929311 1.174568078 0.232130335 0.469342384 1 13.31115699 16.30834645 552889 ataxin 7 like 3B "GO:0005515,GO:0005737,GO:0010468" protein binding|cytoplasm|regulation of gene expression AUH 326.3179925 350.1598091 302.4761759 0.863823226 -0.211191988 0.650081043 1 1.817231175 1.63738567 549 AU RNA binding methylglutaconyl-CoA hydratase "GO:0003730,GO:0004300,GO:0004490,GO:0005739,GO:0005759,GO:0006552,GO:0006635,GO:0009083,GO:0050011" mRNA 3'-UTR binding|enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mitochondrion|mitochondrial matrix|leucine catabolic process|fatty acid beta-oxidation|branched-chain amino acid catabolic process|itaconyl-CoA hydratase activity hsa00280 "Valine, leucine and isoleucine degradation" AUNIP 144.6596793 122.8096722 166.5096864 1.355835281 0.439181918 0.466757884 1 2.57658519 3.643907691 79000 aurora kinase A and ninein interacting protein "GO:0000724,GO:0000922,GO:0003684,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0007051,GO:0090734,GO:2001033" double-strand break repair via homologous recombination|spindle pole|damaged DNA binding|protein binding|nucleus|cytoplasm|centrosome|spindle organization|site of DNA damage|negative regulation of double-strand break repair via nonhomologous end joining AUP1 1869.601589 1620.884681 2118.318496 1.306890317 0.386138066 0.233432391 1 56.30458915 76.75361932 550 AUP1 lipid droplet regulating VLDL assembly factor "GO:0000839,GO:0005515,GO:0005776,GO:0005783,GO:0005811,GO:0009615,GO:0016020,GO:0016032,GO:0030176,GO:0030433,GO:0030970,GO:0031410,GO:0031624,GO:0031625,GO:0034389,GO:0043130,GO:0050790,GO:0061724,GO:0070062,GO:0071712,GO:0097027,GO:0140042,GO:1990044" "Hrd1p ubiquitin ligase ERAD-L complex|protein binding|autophagosome|endoplasmic reticulum|lipid droplet|response to virus|membrane|viral process|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|cytoplasmic vesicle|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|lipid droplet organization|ubiquitin binding|regulation of catalytic activity|lipophagy|extracellular exosome|ER-associated misfolded protein catabolic process|ubiquitin-protein transferase activator activity|lipid droplet formation|protein localization to lipid droplet" AURKA 3449.722744 3692.409813 3207.035676 0.86854814 -0.203322281 0.522886564 1 63.91234825 57.90213786 6790 aurora kinase A "GO:0000086,GO:0000278,GO:0004672,GO:0004674,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005876,GO:0005929,GO:0006468,GO:0006511,GO:0006977,GO:0007051,GO:0007052,GO:0007057,GO:0007100,GO:0009611,GO:0009948,GO:0010389,GO:0010629,GO:0010972,GO:0015630,GO:0018105,GO:0019901,GO:0030496,GO:0031145,GO:0031616,GO:0031625,GO:0031647,GO:0032091,GO:0032133,GO:0032436,GO:0032465,GO:0035174,GO:0035404,GO:0042585,GO:0043066,GO:0043203,GO:0045120,GO:0045840,GO:0046605,GO:0046777,GO:0046982,GO:0048471,GO:0051233,GO:0051301,GO:0051642,GO:0071539,GO:0072687,GO:0097421,GO:0097431,GO:0106310,GO:0106311,GO:1900195,GO:1901796,GO:1990138" "G2/M transition of mitotic cell cycle|mitotic cell cycle|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|centrosome|centriole|spindle|cytosol|spindle microtubule|cilium|protein phosphorylation|ubiquitin-dependent protein catabolic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|spindle organization|mitotic spindle organization|spindle assembly involved in female meiosis I|mitotic centrosome separation|response to wounding|anterior/posterior axis specification|regulation of G2/M transition of mitotic cell cycle|negative regulation of gene expression|negative regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|peptidyl-serine phosphorylation|protein kinase binding|midbody|anaphase-promoting complex-dependent catabolic process|spindle pole centrosome|ubiquitin protein ligase binding|regulation of protein stability|negative regulation of protein binding|chromosome passenger complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of cytokinesis|histone serine kinase activity|histone-serine phosphorylation|germinal vesicle|negative regulation of apoptotic process|axon hillock|pronucleus|positive regulation of mitotic nuclear division|regulation of centrosome cycle|protein autophosphorylation|protein heterodimerization activity|perinuclear region of cytoplasm|spindle midzone|cell division|centrosome localization|protein localization to centrosome|meiotic spindle|liver regeneration|mitotic spindle pole|protein serine kinase activity|protein threonine kinase activity|positive regulation of oocyte maturation|regulation of signal transduction by p53 class mediator|neuron projection extension" "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation AURKAIP1 1477.884754 1615.809902 1339.959607 0.829280477 -0.270067966 0.416410388 1 89.33959747 77.27897668 54998 aurora kinase A interacting protein 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0005840,GO:0006397,GO:0043231,GO:0045839,GO:0045862,GO:0070125,GO:0070126" protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|ribosome|mRNA processing|intracellular membrane-bounded organelle|negative regulation of mitotic nuclear division|positive regulation of proteolysis|mitochondrial translational elongation|mitochondrial translational termination AURKB 1958.098474 1777.187901 2139.009048 1.203591949 0.267346361 0.407665055 1 61.52310159 77.23842783 9212 aurora kinase B "GO:0000122,GO:0000776,GO:0000779,GO:0002903,GO:0004674,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005876,GO:0006468,GO:0006511,GO:0007051,GO:0007052,GO:0007094,GO:0007568,GO:0008283,GO:0008608,GO:0009838,GO:0010369,GO:0016570,GO:0019900,GO:0030496,GO:0031145,GO:0031616,GO:0032091,GO:0032133,GO:0032212,GO:0032465,GO:0032466,GO:0032467,GO:0034501,GO:0034644,GO:0035174,GO:0036089,GO:0043988,GO:0044878,GO:0046777,GO:0046872,GO:0051233,GO:0051256,GO:0051973,GO:0051983,GO:0097431,GO:0106310,GO:0106311,GO:1901796,GO:1904355,GO:1905116,GO:1990023" "negative regulation of transcription by RNA polymerase II|kinetochore|condensed chromosome, centromeric region|negative regulation of B cell apoptotic process|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|spindle|cytosol|spindle microtubule|protein phosphorylation|ubiquitin-dependent protein catabolic process|spindle organization|mitotic spindle organization|mitotic spindle assembly checkpoint|aging|cell population proliferation|attachment of spindle microtubules to kinetochore|abscission|chromocenter|histone modification|kinase binding|midbody|anaphase-promoting complex-dependent catabolic process|spindle pole centrosome|negative regulation of protein binding|chromosome passenger complex|positive regulation of telomere maintenance via telomerase|regulation of cytokinesis|negative regulation of cytokinesis|positive regulation of cytokinesis|protein localization to kinetochore|cellular response to UV|histone serine kinase activity|cleavage furrow formation|histone H3-S28 phosphorylation|mitotic cytokinesis checkpoint|protein autophosphorylation|metal ion binding|spindle midzone|mitotic spindle midzone assembly|positive regulation of telomerase activity|regulation of chromosome segregation|mitotic spindle pole|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|positive regulation of telomere capping|positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore|mitotic spindle midzone" AURKC 4.985705186 4.059823873 5.911586499 1.456118956 0.542128219 0.871693704 1 0.187776947 0.285203637 6795 aurora kinase C "GO:0000793,GO:0004672,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0005876,GO:0006468,GO:0007052,GO:0007283,GO:0008608,GO:0016570,GO:0030496,GO:0031616,GO:0032133,GO:0032465,GO:0032467,GO:0035174,GO:0035404,GO:0048599,GO:0051233,GO:0051256,GO:0051301,GO:0051321,GO:0106310,GO:0106311" condensed chromosome|protein kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|spindle|spindle microtubule|protein phosphorylation|mitotic spindle organization|spermatogenesis|attachment of spindle microtubules to kinetochore|histone modification|midbody|spindle pole centrosome|chromosome passenger complex|regulation of cytokinesis|positive regulation of cytokinesis|histone serine kinase activity|histone-serine phosphorylation|oocyte development|spindle midzone|mitotic spindle midzone assembly|cell division|meiotic cell cycle|protein serine kinase activity|protein threonine kinase activity AVEN 146.5411335 116.7199364 176.3623306 1.510987206 0.595491445 0.319754411 1 2.149619278 3.387959929 57099 apoptosis and caspase activation inhibitor "GO:0005515,GO:0005829,GO:0006915,GO:0010972,GO:0012505,GO:0016020,GO:0043066" protein binding|cytosol|apoptotic process|negative regulation of G2/M transition of mitotic cell cycle|endomembrane system|membrane|negative regulation of apoptotic process AVIL 33.48142278 32.47859099 34.48425458 1.061753405 0.086448736 0.961865394 1 0.390255292 0.432203613 10677 advillin "GO:0003779,GO:0005515,GO:0005546,GO:0005737,GO:0005884,GO:0005925,GO:0007015,GO:0007399,GO:0008154,GO:0010592,GO:0010976,GO:0015629,GO:0030027,GO:0030424,GO:0042995,GO:0043005,GO:0051014,GO:0051015,GO:0051016,GO:0060271,GO:0071933,GO:1900480" "actin binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|actin filament|focal adhesion|actin filament organization|nervous system development|actin polymerization or depolymerization|positive regulation of lamellipodium assembly|positive regulation of neuron projection development|actin cytoskeleton|lamellipodium|axon|cell projection|neuron projection|actin filament severing|actin filament binding|barbed-end actin filament capping|cilium assembly|Arp2/3 complex binding|regulation of diacylglycerol biosynthetic process" AVL9 1625.81075 1591.450958 1660.170542 1.043180459 0.060988751 0.854278732 1 9.027931983 9.823441235 23080 AVL9 cell migration associated "GO:0005737,GO:0016021,GO:0016477,GO:0055037" cytoplasm|integral component of membrane|cell migration|recycling endosome AVP 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.023919935 0.121102056 551 arginine vasopressin "GO:0002125,GO:0003084,GO:0003091,GO:0004672,GO:0005102,GO:0005184,GO:0005185,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006091,GO:0006468,GO:0006833,GO:0006915,GO:0007165,GO:0007186,GO:0007204,GO:0007267,GO:0007621,GO:0007625,GO:0007626,GO:0008284,GO:0010628,GO:0014049,GO:0030141,GO:0030307,GO:0030425,GO:0030665,GO:0031394,GO:0031894,GO:0031895,GO:0032849,GO:0033138,GO:0033574,GO:0035094,GO:0035176,GO:0035813,GO:0042310,GO:0042538,GO:0042711,GO:0043027,GO:0043066,GO:0043084,GO:0043154,GO:0045471,GO:0045907,GO:0051970,GO:0061024,GO:0070371,GO:0070528,GO:0090201" maternal aggressive behavior|positive regulation of systemic arterial blood pressure|renal water homeostasis|protein kinase activity|signaling receptor binding|neuropeptide hormone activity|neurohypophyseal hormone activity|protein binding|extracellular region|extracellular space|cytosol|generation of precursor metabolites and energy|protein phosphorylation|water transport|apoptotic process|signal transduction|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|negative regulation of female receptivity|grooming behavior|locomotory behavior|positive regulation of cell population proliferation|positive regulation of gene expression|positive regulation of glutamate secretion|secretory granule|positive regulation of cell growth|dendrite|clathrin-coated vesicle membrane|positive regulation of prostaglandin biosynthetic process|V1A vasopressin receptor binding|V1B vasopressin receptor binding|positive regulation of cellular pH reduction|positive regulation of peptidyl-serine phosphorylation|response to testosterone|response to nicotine|social behavior|regulation of renal sodium excretion|vasoconstriction|hyperosmotic salinity response|maternal behavior|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|penile erection|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to ethanol|positive regulation of vasoconstriction|negative regulation of transmission of nerve impulse|membrane organization|ERK1 and ERK2 cascade|protein kinase C signaling|negative regulation of release of cytochrome c from mitochondria "hsa04072,hsa04080,hsa04270,hsa04962" Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Vasopressin-regulated water reabsorption AVPI1 242.2763232 296.3671428 188.1855036 0.634974248 -0.655230012 0.196085966 1 10.90047223 7.219670129 60370 arginine vasopressin induced 1 "GO:0000187,GO:0005515,GO:0007049" activation of MAPK activity|protein binding|cell cycle AVPR2 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.10648149 0 554 arginine vasopressin receptor 2 "GO:0001992,GO:0003091,GO:0004930,GO:0005000,GO:0005515,GO:0005768,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0007186,GO:0007188,GO:0007190,GO:0007588,GO:0007599,GO:0008285,GO:0010628,GO:0016021,GO:0030139,GO:0030665,GO:0042277,GO:0045907,GO:0048471,GO:0061024" regulation of systemic arterial blood pressure by vasopressin|renal water homeostasis|G protein-coupled receptor activity|vasopressin receptor activity|protein binding|endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|excretion|hemostasis|negative regulation of cell population proliferation|positive regulation of gene expression|integral component of membrane|endocytic vesicle|clathrin-coated vesicle membrane|peptide binding|positive regulation of vasoconstriction|perinuclear region of cytoplasm|membrane organization "hsa04072,hsa04080,hsa04962" Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Vasopressin-regulated water reabsorption AXDND1 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.048289281 0.048895879 126859 axonemal dynein light chain domain containing 1 AXIN1 857.5210031 764.2618442 950.780162 1.244050281 0.315044796 0.385067874 1 7.189295367 9.329109487 8312 axin 1 "GO:0001934,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0007275,GO:0008013,GO:0010800,GO:0016055,GO:0016328,GO:0019899,GO:0019901,GO:0030111,GO:0030159,GO:0030877,GO:0031398,GO:0031410,GO:0031625,GO:0032147,GO:0033138,GO:0033146,GO:0034622,GO:0035591,GO:0042802,GO:0042803,GO:0045732,GO:0045893,GO:0046330,GO:0046332,GO:0048471,GO:0051443,GO:0060090,GO:0070016,GO:0070411,GO:0071944,GO:0090090,GO:0090263,GO:1904885,GO:1904886,GO:2000060" "positive regulation of protein phosphorylation|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|multicellular organism development|beta-catenin binding|positive regulation of peptidyl-threonine phosphorylation|Wnt signaling pathway|lateral plasma membrane|enzyme binding|protein kinase binding|regulation of Wnt signaling pathway|signaling receptor complex adaptor activity|beta-catenin destruction complex|positive regulation of protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase binding|activation of protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of intracellular estrogen receptor signaling pathway|cellular protein-containing complex assembly|signaling adaptor activity|identical protein binding|protein homodimerization activity|positive regulation of protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|SMAD binding|perinuclear region of cytoplasm|positive regulation of ubiquitin-protein transferase activity|molecular adaptor activity|armadillo repeat domain binding|I-SMAD binding|cell periphery|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|beta-catenin destruction complex assembly|beta-catenin destruction complex disassembly|positive regulation of ubiquitin-dependent protein catabolic process" "hsa04310,hsa04390,hsa04550,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer AXIN2 67.21522376 82.21143344 52.21901408 0.635179462 -0.65476383 0.399692332 1 0.774213291 0.512947597 8313 axin 2 "GO:0001756,GO:0001934,GO:0001957,GO:0003139,GO:0003413,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0008013,GO:0008283,GO:0008285,GO:0010718,GO:0010942,GO:0016055,GO:0019899,GO:0030282,GO:0030877,GO:0031625,GO:0032423,GO:0034613,GO:0042476,GO:0043570,GO:0045668,GO:0048255,GO:0061181,GO:0070411,GO:0070602,GO:0090090,GO:0090263,GO:1904837" somitogenesis|positive regulation of protein phosphorylation|intramembranous ossification|secondary heart field specification|chondrocyte differentiation involved in endochondral bone morphogenesis|protein binding|nucleus|cytoplasm|centrosome|cytosol|beta-catenin binding|cell population proliferation|negative regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of cell death|Wnt signaling pathway|enzyme binding|bone mineralization|beta-catenin destruction complex|ubiquitin protein ligase binding|regulation of mismatch repair|cellular protein localization|odontogenesis|maintenance of DNA repeat elements|negative regulation of osteoblast differentiation|mRNA stabilization|regulation of chondrocyte development|I-SMAD binding|regulation of centromeric sister chromatid cohesion|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly "hsa04310,hsa04390,hsa04550,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer AXL 6186.949113 3905.550566 8468.34766 2.168285243 1.116554559 0.000679917 0.072436431 40.57484271 91.76756094 558 AXL receptor tyrosine kinase "GO:0001618,GO:0001764,GO:0001779,GO:0001786,GO:0001961,GO:0001974,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005615,GO:0005886,GO:0005887,GO:0006909,GO:0006954,GO:0007165,GO:0007169,GO:0007275,GO:0007283,GO:0007399,GO:0009986,GO:0015629,GO:0016477,GO:0018108,GO:0021885,GO:0030168,GO:0031100,GO:0031668,GO:0032036,GO:0032689,GO:0032720,GO:0032825,GO:0032940,GO:0033674,GO:0034101,GO:0034446,GO:0035457,GO:0042698,GO:0043066,GO:0043231,GO:0043235,GO:0043491,GO:0043524,GO:0043548,GO:0044228,GO:0045087,GO:0046718,GO:0048010,GO:0048469,GO:0048549,GO:0051250,GO:0051897,GO:0060068,GO:0070062,GO:0070301,GO:0071222,GO:0097028,GO:0097350,GO:1903902,GO:2000669" virus receptor activity|neuron migration|natural killer cell differentiation|phosphatidylserine binding|positive regulation of cytokine-mediated signaling pathway|blood vessel remodeling|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|extracellular space|plasma membrane|integral component of plasma membrane|phagocytosis|inflammatory response|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|spermatogenesis|nervous system development|cell surface|actin cytoskeleton|cell migration|peptidyl-tyrosine phosphorylation|forebrain cell migration|platelet activation|animal organ regeneration|cellular response to extracellular stimulus|myosin heavy chain binding|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of natural killer cell differentiation|secretion by cell|positive regulation of kinase activity|erythrocyte homeostasis|substrate adhesion-dependent cell spreading|cellular response to interferon-alpha|ovulation cycle|negative regulation of apoptotic process|intracellular membrane-bounded organelle|receptor complex|protein kinase B signaling|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|host cell surface|innate immune response|viral entry into host cell|vascular endothelial growth factor receptor signaling pathway|cell maturation|positive regulation of pinocytosis|negative regulation of lymphocyte activation|positive regulation of protein kinase B signaling|vagina development|extracellular exosome|cellular response to hydrogen peroxide|cellular response to lipopolysaccharide|dendritic cell differentiation|neutrophil clearance|positive regulation of viral life cycle|negative regulation of dendritic cell apoptotic process hsa01521 EGFR tyrosine kinase inhibitor resistance AZI2 1409.0986 1392.519589 1425.677611 1.02381153 0.033950159 0.921209054 1 14.75752347 15.75975379 64343 5-azacytidine induced 2 "GO:0000278,GO:0005515,GO:0005737,GO:0007249,GO:0016032,GO:0042110,GO:0044565,GO:0097028" mitotic cell cycle|protein binding|cytoplasm|I-kappaB kinase/NF-kappaB signaling|viral process|T cell activation|dendritic cell proliferation|dendritic cell differentiation hsa04622 RIG-I-like receptor signaling pathway AZIN1 6128.354588 5389.416192 6867.292983 1.274218345 0.349612514 0.281977916 1 62.30424958 82.80898335 51582 antizyme inhibitor 1 "GO:0004586,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006521,GO:0033387,GO:0042177,GO:0042978,GO:0050790,GO:1902269" ornithine decarboxylase activity|protein binding|nucleus|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|putrescine biosynthetic process from ornithine|negative regulation of protein catabolic process|ornithine decarboxylase activator activity|regulation of catalytic activity|positive regulation of polyamine transmembrane transport AZIN2 66.11391474 40.59823873 91.62959074 2.256984381 1.174396435 0.132652823 1 0.503343346 1.184973984 113451 antizyme inhibitor 2 "GO:0004586,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005801,GO:0005802,GO:0005829,GO:0007283,GO:0008792,GO:0030133,GO:0030424,GO:0030425,GO:0031410,GO:0033116,GO:0033387,GO:0042177,GO:0042978,GO:0043085,GO:0043204,GO:0048471,GO:0097055,GO:0098629,GO:1902269,GO:1990005" ornithine decarboxylase activity|protein binding|nucleus|cytoplasm|mitochondrion|cis-Golgi network|trans-Golgi network|cytosol|spermatogenesis|arginine decarboxylase activity|transport vesicle|axon|dendrite|cytoplasmic vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|putrescine biosynthetic process from ornithine|negative regulation of protein catabolic process|ornithine decarboxylase activator activity|positive regulation of catalytic activity|perikaryon|perinuclear region of cytoplasm|agmatine biosynthetic process|trans-Golgi network membrane organization|positive regulation of polyamine transmembrane transport|granular vesicle hsa00330 Arginine and proline metabolism B2M 10641.02424 10418.52302 10863.52546 1.042712623 0.060341598 0.858621957 1 545.1047897 592.8714794 567 beta-2-microglobulin "GO:0000139,GO:0001895,GO:0001916,GO:0002237,GO:0002474,GO:0002479,GO:0002480,GO:0002481,GO:0002726,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0006826,GO:0007611,GO:0009897,GO:0010977,GO:0012507,GO:0016020,GO:0019885,GO:0030670,GO:0031901,GO:0031905,GO:0032092,GO:0033077,GO:0034756,GO:0035580,GO:0042026,GO:0042493,GO:0042612,GO:0042802,GO:0042803,GO:0042824,GO:0043312,GO:0044267,GO:0045087,GO:0045646,GO:0046686,GO:0048260,GO:0050680,GO:0050690,GO:0050768,GO:0050776,GO:0051289,GO:0055038,GO:0055072,GO:0060333,GO:0070062,GO:0071281,GO:0071283,GO:0071316,GO:0090647,GO:1900121,GO:1900122,GO:1904434,GO:1904437,GO:1904724,GO:1990000,GO:1990712,GO:2000774,GO:2000978" "Golgi membrane|retina homeostasis|positive regulation of T cell mediated cytotoxicity|response to molecule of bacterial origin|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|positive regulation of T cell cytokine production|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|cytosol|plasma membrane|focal adhesion|iron ion transport|learning or memory|external side of plasma membrane|negative regulation of neuron projection development|ER to Golgi transport vesicle membrane|membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|phagocytic vesicle membrane|early endosome membrane|early endosome lumen|positive regulation of protein binding|T cell differentiation in thymus|regulation of iron ion transport|specific granule lumen|protein refolding|response to drug|MHC class I protein complex|identical protein binding|protein homodimerization activity|MHC class I peptide loading complex|neutrophil degranulation|cellular protein metabolic process|innate immune response|regulation of erythrocyte differentiation|response to cadmium ion|positive regulation of receptor-mediated endocytosis|negative regulation of epithelial cell proliferation|regulation of defense response to virus by virus|negative regulation of neurogenesis|regulation of immune response|protein homotetramerization|recycling endosome membrane|iron ion homeostasis|interferon-gamma-mediated signaling pathway|extracellular exosome|cellular response to iron ion|cellular response to iron(III) ion|cellular response to nicotine|modulation of age-related behavioral decline|negative regulation of receptor binding|positive regulation of receptor binding|positive regulation of ferrous iron binding|positive regulation of transferrin receptor binding|tertiary granule lumen|amyloid fibril formation|HFE-transferrin receptor complex|positive regulation of cellular senescence|negative regulation of forebrain neuron differentiation" "hsa04612,hsa05163,hsa05166,hsa05168,hsa05169,hsa05170" Antigen processing and presentation|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection B3GALNT1 455.5454914 428.3114187 482.7795641 1.127169492 0.172704469 0.682875877 1 4.485620836 5.2738493 8706 "beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)" "GO:0000139,GO:0005794,GO:0006486,GO:0006687,GO:0008375,GO:0008376,GO:0008499,GO:0008532,GO:0009312,GO:0016021,GO:0030311,GO:0047273" "Golgi membrane|Golgi apparatus|protein glycosylation|glycosphingolipid metabolic process|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|oligosaccharide biosynthetic process|integral component of membrane|poly-N-acetyllactosamine biosynthetic process|galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity" "hsa00601,hsa00603" Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series B3GALNT2 808.4250451 910.4155036 706.4345867 0.775947448 -0.365969147 0.318355193 1 5.854410044 4.738396252 148789 "beta-1,3-N-acetylgalactosaminyltransferase 2" "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0006486,GO:0006493,GO:0008376,GO:0016021" Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|protein O-linked glycosylation|acetylgalactosaminyltransferase activity|integral component of membrane hsa00515 Mannose type O-glycan biosynthesis B3GALT4 36.95953979 34.50850292 39.41057666 1.142054083 0.191630972 0.86297939 1 1.026267724 1.222540545 8705 "beta-1,3-galactosyltransferase 4" "GO:0000139,GO:0001574,GO:0005794,GO:0006486,GO:0008375,GO:0008376,GO:0008499,GO:0016021,GO:0047915" "Golgi membrane|ganglioside biosynthetic process|Golgi apparatus|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|integral component of membrane|ganglioside galactosyltransferase activity" hsa00604 Glycosphingolipid biosynthesis - ganglio series B3GALT6 767.2517805 924.6248872 609.8786738 0.65959578 -0.600345926 0.105487256 1 16.69482662 11.48618247 126792 "beta-1,3-galactosyltransferase 6" "GO:0000139,GO:0005794,GO:0005797,GO:0006024,GO:0006486,GO:0008499,GO:0015012,GO:0016020,GO:0016021,GO:0018215,GO:0030166,GO:0030203,GO:0030206,GO:0032580,GO:0035250,GO:0047220" "Golgi membrane|Golgi apparatus|Golgi medial cisterna|glycosaminoglycan biosynthetic process|protein glycosylation|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|heparan sulfate proteoglycan biosynthetic process|membrane|integral component of membrane|protein phosphopantetheinylation|proteoglycan biosynthetic process|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|UDP-galactosyltransferase activity|galactosylxylosylprotein 3-beta-galactosyltransferase activity" "hsa00532,hsa00534" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin B3GALT9 71.84190872 95.40586103 48.27795641 0.506027155 -0.982713289 0.194816495 1 1.253104328 0.661419482 100288842 "beta-1,3-galactosyltransferase 9" "GO:0000139,GO:0005794,GO:0006486,GO:0008375,GO:0008376,GO:0016021" Golgi membrane|Golgi apparatus|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|integral component of membrane B3GAT3 621.9079578 586.6445497 657.1713658 1.120220696 0.163782987 0.675031106 1 17.57035889 20.53052968 26229 "beta-1,3-glucuronyltransferase 3" "GO:0000139,GO:0005515,GO:0005794,GO:0005801,GO:0005975,GO:0006024,GO:0006486,GO:0015012,GO:0015018,GO:0015020,GO:0016020,GO:0016021,GO:0030203,GO:0043085,GO:0043666,GO:0046872,GO:0050650,GO:0050651,GO:0070062,GO:0072542,GO:0090316" Golgi membrane|protein binding|Golgi apparatus|cis-Golgi network|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|protein glycosylation|heparan sulfate proteoglycan biosynthetic process|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|glucuronosyltransferase activity|membrane|integral component of membrane|glycosaminoglycan metabolic process|positive regulation of catalytic activity|regulation of phosphoprotein phosphatase activity|metal ion binding|chondroitin sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular exosome|protein phosphatase activator activity|positive regulation of intracellular protein transport "hsa00532,hsa00534" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin B3GLCT 467.3389728 426.2815067 508.3964389 1.192630764 0.254147457 0.542735561 1 4.606284294 5.730238206 145173 beta 3-glucosyltransferase "GO:0005789,GO:0006004,GO:0008375,GO:0016021,GO:0016757,GO:0036066" "endoplasmic reticulum membrane|fucose metabolic process|acetylglucosaminyltransferase activity|integral component of membrane|transferase activity, transferring glycosyl groups|protein O-linked fucosylation" hsa00514 Other types of O-glycan biosynthesis B3GNT2 302.0063082 270.9932436 333.0193728 1.228884412 0.297349223 0.530953541 1 4.800577747 6.153475458 10678 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2" "GO:0000139,GO:0005515,GO:0005794,GO:0006486,GO:0007411,GO:0007608,GO:0008375,GO:0008376,GO:0008457,GO:0008532,GO:0016021,GO:0016266,GO:0018146,GO:0030311,GO:1990830" "Golgi membrane|protein binding|Golgi apparatus|protein glycosylation|axon guidance|sensory perception of smell|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|poly-N-acetyllactosamine biosynthetic process|cellular response to leukemia inhibitory factor" "hsa00533,hsa00601" Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT3 3.955903442 1.014955968 6.896850916 6.795221794 2.764520641 0.248209988 1 0.018705946 0.13258648 10331 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3" "GO:0000139,GO:0005794,GO:0005887,GO:0006486,GO:0008375,GO:0008376,GO:0008457,GO:0008532,GO:0016266,GO:0018146,GO:0018215,GO:0030311,GO:0047223" "Golgi membrane|Golgi apparatus|integral component of plasma membrane|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|O-glycan processing|keratan sulfate biosynthetic process|protein phosphopantetheinylation|poly-N-acetyllactosamine biosynthetic process|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT4 57.93216228 53.79266632 62.07165824 1.153905588 0.206525188 0.816240807 1 0.942375918 1.134254173 79369 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4" "GO:0000139,GO:0005794,GO:0006486,GO:0008375,GO:0008376,GO:0008457,GO:0008532,GO:0016021,GO:0016266,GO:0018146,GO:0030311" "Golgi membrane|Golgi apparatus|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|poly-N-acetyllactosamine biosynthetic process" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT5 955.4560892 1060.628987 850.2831915 0.801678251 -0.318904759 0.369581995 1 7.480450705 6.255237401 84002 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5" "GO:0000139,GO:0005515,GO:0005794,GO:0006486,GO:0007417,GO:0007420,GO:0008375,GO:0008376,GO:0008457,GO:0009247,GO:0016021,GO:0016266,GO:0047256" "Golgi membrane|protein binding|Golgi apparatus|protein glycosylation|central nervous system development|brain development|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|glycolipid biosynthetic process|integral component of membrane|O-glycan processing|lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT7 19.58380052 25.37389921 13.79370183 0.543617743 -0.879335549 0.443480744 1 0.353146051 0.200246027 93010 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7" "GO:0000139,GO:0005515,GO:0005794,GO:0006486,GO:0008375,GO:0008376,GO:0008532,GO:0016021,GO:0016266,GO:0018146,GO:0030311" "Golgi membrane|protein binding|Golgi apparatus|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|poly-N-acetyllactosamine biosynthetic process" hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate B3GNT9 432.5105438 436.4310664 428.5900212 0.982033714 -0.02615554 0.956716404 1 8.180493663 8.379572062 84752 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9" "GO:0000139,GO:0005794,GO:0006486,GO:0008375,GO:0008376,GO:0008532,GO:0016021,GO:0030311" "Golgi membrane|Golgi apparatus|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|integral component of membrane|poly-N-acetyllactosamine biosynthetic process" B3GNTL1 126.1178047 134.9891438 117.2464656 0.868562184 -0.203298953 0.75492209 1 1.260690378 1.14215563 146712 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1" GO:0016757 "transferase activity, transferring glycosyl groups" B4GALNT1 2345.24108 2042.091408 2648.390752 1.296901177 0.375068552 0.240759449 1 15.48274338 20.94453534 2583 "beta-1,4-N-acetyl-galactosaminyltransferase 1" "GO:0000139,GO:0001574,GO:0003947,GO:0005794,GO:0005886,GO:0005975,GO:0006687,GO:0007283,GO:0008376,GO:0016020,GO:0019915,GO:0030173,GO:0030259" Golgi membrane|ganglioside biosynthetic process|(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity|Golgi apparatus|plasma membrane|carbohydrate metabolic process|glycosphingolipid metabolic process|spermatogenesis|acetylgalactosaminyltransferase activity|membrane|lipid storage|integral component of Golgi membrane|lipid glycosylation hsa00604 Glycosphingolipid biosynthesis - ganglio series B4GALNT3 17.43512238 13.19442759 21.67581716 1.642800873 0.716157619 0.557216498 1 0.121655054 0.208463973 283358 "beta-1,4-N-acetyl-galactosaminyltransferase 3" "GO:0005794,GO:0008376,GO:0016021,GO:0018215,GO:0032580,GO:0033842,GO:0043231" Golgi apparatus|acetylgalactosaminyltransferase activity|integral component of membrane|protein phosphopantetheinylation|Golgi cisterna membrane|N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity|intracellular membrane-bounded organelle hsa00513 Various types of N-glycan biosynthesis B4GALNT4 843.2737632 834.293806 852.2537203 1.021527086 0.030727458 0.936025166 1 8.091543099 8.621784586 338707 "beta-1,4-N-acetyl-galactosaminyltransferase 4" "GO:0008376,GO:0016021,GO:0018215,GO:0032580,GO:0033842" acetylgalactosaminyltransferase activity|integral component of membrane|protein phosphopantetheinylation|Golgi cisterna membrane|N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity hsa00513 Various types of N-glycan biosynthesis B4GALT1 3860.36596 3913.670214 3807.061706 0.972759966 -0.039844239 0.901190931 1 42.13724272 42.7550809 2683 "beta-1,4-galactosyltransferase 1" "GO:0000138,GO:0000139,GO:0002064,GO:0002526,GO:0003831,GO:0003945,GO:0004461,GO:0005615,GO:0005794,GO:0005886,GO:0005989,GO:0006012,GO:0006487,GO:0007155,GO:0007339,GO:0007341,GO:0008285,GO:0008378,GO:0009312,GO:0009897,GO:0016020,GO:0016021,GO:0016323,GO:0018146,GO:0030057,GO:0030145,GO:0030175,GO:0030198,GO:0030667,GO:0031526,GO:0032580,GO:0035250,GO:0035577,GO:0043065,GO:0043312,GO:0045136,GO:0050900,GO:0060046,GO:0060054,GO:0060055,GO:0070062" "Golgi trans cisterna|Golgi membrane|epithelial cell development|acute inflammatory response|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|N-acetyllactosamine synthase activity|lactose synthase activity|extracellular space|Golgi apparatus|plasma membrane|lactose biosynthetic process|galactose metabolic process|protein N-linked glycosylation|cell adhesion|binding of sperm to zona pellucida|penetration of zona pellucida|negative regulation of cell population proliferation|galactosyltransferase activity|oligosaccharide biosynthetic process|external side of plasma membrane|membrane|integral component of membrane|basolateral plasma membrane|keratan sulfate biosynthetic process|desmosome|manganese ion binding|filopodium|extracellular matrix organization|secretory granule membrane|brush border membrane|Golgi cisterna membrane|UDP-galactosyltransferase activity|azurophil granule membrane|positive regulation of apoptotic process|neutrophil degranulation|development of secondary sexual characteristics|leukocyte migration|regulation of acrosome reaction|positive regulation of epithelial cell proliferation involved in wound healing|angiogenesis involved in wound healing|extracellular exosome" "hsa00052,hsa00510,hsa00513,hsa00514,hsa00515,hsa00533,hsa00601" Galactose metabolism|N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT2 1670.964167 1647.273537 1694.654796 1.028763444 0.040911284 0.902313935 1 33.58639026 36.04082994 8704 "beta-1,4-galactosyltransferase 2" "GO:0000139,GO:0003831,GO:0003945,GO:0004461,GO:0005654,GO:0005794,GO:0005975,GO:0006486,GO:0007613,GO:0007626,GO:0008378,GO:0008542,GO:0016021,GO:0018146,GO:0021680,GO:0032580,GO:0043231,GO:0046872" "Golgi membrane|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|N-acetyllactosamine synthase activity|lactose synthase activity|nucleoplasm|Golgi apparatus|carbohydrate metabolic process|protein glycosylation|memory|locomotory behavior|galactosyltransferase activity|visual learning|integral component of membrane|keratan sulfate biosynthetic process|cerebellar Purkinje cell layer development|Golgi cisterna membrane|intracellular membrane-bounded organelle|metal ion binding" "hsa00052,hsa00510,hsa00513,hsa00514,hsa00515,hsa00533,hsa00601" Galactose metabolism|N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT3 1397.485989 1373.235425 1421.736553 1.035318873 0.050075179 0.883003097 1 30.69264334 33.14548311 8703 "beta-1,4-galactosyltransferase 3" "GO:0000139,GO:0003831,GO:0003945,GO:0005794,GO:0005829,GO:0005975,GO:0006486,GO:0006682,GO:0008378,GO:0016021,GO:0018146,GO:0032580,GO:0046872,GO:0070062" "Golgi membrane|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|N-acetyllactosamine synthase activity|Golgi apparatus|cytosol|carbohydrate metabolic process|protein glycosylation|galactosylceramide biosynthetic process|galactosyltransferase activity|integral component of membrane|keratan sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding|extracellular exosome" "hsa00510,hsa00513,hsa00514,hsa00515,hsa00533,hsa00601" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT4 441.6303017 453.6853179 429.5752856 0.946857367 -0.078780978 0.856697742 1 7.812839457 7.716305126 8702 "beta-1,4-galactosyltransferase 4" "GO:0000139,GO:0003945,GO:0005794,GO:0005975,GO:0006486,GO:0006643,GO:0008378,GO:0016021,GO:0018146,GO:0032580,GO:0046872" Golgi membrane|N-acetyllactosamine synthase activity|Golgi apparatus|carbohydrate metabolic process|protein glycosylation|membrane lipid metabolic process|galactosyltransferase activity|integral component of membrane|keratan sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding "hsa00533,hsa00601" Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT5 6872.737945 7579.691172 6165.784719 0.813461206 -0.29785455 0.362724497 1 81.29703903 68.98068519 9334 "beta-1,4-galactosyltransferase 5" "GO:0000139,GO:0003945,GO:0006486,GO:0008378,GO:0008489,GO:0010706,GO:0016021,GO:0016266,GO:0018146,GO:0021955,GO:0022010,GO:0030311,GO:0031647,GO:0032580,GO:0040019,GO:0042551,GO:0046872" "Golgi membrane|N-acetyllactosamine synthase activity|protein glycosylation|galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity|ganglioside biosynthetic process via lactosylceramide|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|central nervous system neuron axonogenesis|central nervous system myelination|poly-N-acetyllactosamine biosynthetic process|regulation of protein stability|Golgi cisterna membrane|positive regulation of embryonic development|neuron maturation|metal ion binding" hsa00512 Mucin type O-glycan biosynthesis B4GALT6 591.931622 591.7193296 592.1439143 1.000717544 0.001034826 1 1 4.114291129 4.294597459 9331 "beta-1,4-galactosyltransferase 6" "GO:0000139,GO:0001572,GO:0005975,GO:0006486,GO:0008378,GO:0008489,GO:0010706,GO:0016021,GO:0018146,GO:0021955,GO:0022010,GO:0032580,GO:0042551,GO:0046872" "Golgi membrane|lactosylceramide biosynthetic process|carbohydrate metabolic process|protein glycosylation|galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity|ganglioside biosynthetic process via lactosylceramide|integral component of membrane|keratan sulfate biosynthetic process|central nervous system neuron axonogenesis|central nervous system myelination|Golgi cisterna membrane|neuron maturation|metal ion binding" hsa00600 Sphingolipid metabolism B4GALT7 883.938066 1021.045704 746.8304277 0.731436825 -0.451194833 0.210632328 1 25.869116 19.73669089 11285 "beta-1,4-galactosyltransferase 7" "GO:0000139,GO:0003831,GO:0005515,GO:0005794,GO:0005975,GO:0006024,GO:0006029,GO:0006464,GO:0006487,GO:0008378,GO:0016021,GO:0018215,GO:0030145,GO:0030203,GO:0032580,GO:0046525,GO:0048147,GO:0097435" "Golgi membrane|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|protein binding|Golgi apparatus|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|cellular protein modification process|protein N-linked glycosylation|galactosyltransferase activity|integral component of membrane|protein phosphopantetheinylation|manganese ion binding|glycosaminoglycan metabolic process|Golgi cisterna membrane|xylosylprotein 4-beta-galactosyltransferase activity|negative regulation of fibroblast proliferation|supramolecular fiber organization" "hsa00532,hsa00534" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin B4GAT1 697.7839582 823.1292904 572.438626 0.695441934 -0.523998032 0.165814721 1 20.77159678 15.06769039 11041 "beta-1,4-glucuronyltransferase 1" "GO:0000139,GO:0005515,GO:0005794,GO:0006493,GO:0008532,GO:0015020,GO:0018146,GO:0030173,GO:0030311,GO:0035269,GO:0046872,GO:0070062" "Golgi membrane|protein binding|Golgi apparatus|protein O-linked glycosylation|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|glucuronosyltransferase activity|keratan sulfate biosynthetic process|integral component of Golgi membrane|poly-N-acetyllactosamine biosynthetic process|protein O-linked mannosylation|metal ion binding|extracellular exosome" hsa00515 Mannose type O-glycan biosynthesis B9D1 371.0530056 411.0571672 331.048844 0.80535962 -0.312294956 0.48253834 1 3.041431029 2.554957926 27077 B9 domain containing 1 "GO:0005515,GO:0005813,GO:0005829,GO:0007224,GO:0008158,GO:0035869,GO:0036038,GO:0036064,GO:0060271,GO:0097711" protein binding|centrosome|cytosol|smoothened signaling pathway|hedgehog receptor activity|ciliary transition zone|MKS complex|ciliary basal body|cilium assembly|ciliary basal body-plasma membrane docking B9D2 43.57159936 48.71788648 38.42531225 0.788731101 -0.342394563 0.715132091 1 2.101694279 1.729077414 80776 B9 domain containing 2 "GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0016020,GO:0036038,GO:0036064,GO:0043015,GO:0060271,GO:0097711" protein binding|nucleus|centrosome|cytosol|membrane|MKS complex|ciliary basal body|gamma-tubulin binding|cilium assembly|ciliary basal body-plasma membrane docking BAALC 13.58313937 19.2841634 7.882115332 0.408735145 -1.290761795 0.314396824 1 0.334248749 0.142504213 79870 BAALC binder of MAP3K1 and KLF4 "GO:0005654,GO:0005737,GO:0005829,GO:0014069,GO:0043005,GO:0045121" nucleoplasm|cytoplasm|cytosol|postsynaptic density|neuron projection|membrane raft BABAM1 1425.580871 1374.250381 1476.91136 1.074703257 0.103938363 0.75684469 1 49.57331463 55.57154266 29086 BRISC and BRCA1 A complex member 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006302,GO:0006303,GO:0006325,GO:0007049,GO:0010212,GO:0016579,GO:0016604,GO:0045739,GO:0051301,GO:0070531,GO:0070536,GO:0070552,GO:0072425" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|chromatin organization|cell cycle|response to ionizing radiation|protein deubiquitination|nuclear body|positive regulation of DNA repair|cell division|BRCA1-A complex|protein K63-linked deubiquitination|BRISC complex|signal transduction involved in G2 DNA damage checkpoint hsa03440 Homologous recombination BABAM2 648.9985238 822.1143344 475.8827132 0.578852227 -0.788733 0.040564242 0.927001456 18.85742337 11.38586394 9577 BRISC and BRCA1 A complex member 2 "GO:0000152,GO:0000268,GO:0005164,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006302,GO:0006303,GO:0006325,GO:0006915,GO:0006974,GO:0007049,GO:0007165,GO:0010212,GO:0016579,GO:0031593,GO:0043066,GO:0045739,GO:0051301,GO:0070531,GO:0070536,GO:0070552,GO:0072425" nuclear ubiquitin ligase complex|peroxisome targeting sequence binding|tumor necrosis factor receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|chromatin organization|apoptotic process|cellular response to DNA damage stimulus|cell cycle|signal transduction|response to ionizing radiation|protein deubiquitination|polyubiquitin modification-dependent protein binding|negative regulation of apoptotic process|positive regulation of DNA repair|cell division|BRCA1-A complex|protein K63-linked deubiquitination|BRISC complex|signal transduction involved in G2 DNA damage checkpoint hsa03440 Homologous recombination BACE1 613.0769505 690.1700585 535.9838426 0.776596776 -0.364762376 0.348793638 1 5.913496648 4.790224506 23621 beta-secretase 1 "GO:0001540,GO:0004175,GO:0004190,GO:0005515,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005771,GO:0005788,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0006508,GO:0006509,GO:0008021,GO:0008233,GO:0008798,GO:0009314,GO:0009986,GO:0010008,GO:0010288,GO:0016020,GO:0016021,GO:0016485,GO:0019899,GO:0030424,GO:0030425,GO:0030659,GO:0034205,GO:0042987,GO:0043025,GO:0043525,GO:0044267,GO:0045121,GO:0050435,GO:0050966,GO:0055037,GO:0060134,GO:0070931,GO:0071280,GO:0071287,GO:0098686,GO:1904646,GO:2000300" amyloid-beta binding|endopeptidase activity|aspartic-type endopeptidase activity|protein binding|lysosome|endosome|early endosome|late endosome|multivesicular body|endoplasmic reticulum lumen|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|proteolysis|membrane protein ectodomain proteolysis|synaptic vesicle|peptidase activity|beta-aspartyl-peptidase activity|response to radiation|cell surface|endosome membrane|response to lead ion|membrane|integral component of membrane|protein processing|enzyme binding|axon|dendrite|cytoplasmic vesicle membrane|amyloid-beta formation|amyloid precursor protein catabolic process|neuronal cell body|positive regulation of neuron apoptotic process|cellular protein metabolic process|membrane raft|amyloid-beta metabolic process|detection of mechanical stimulus involved in sensory perception of pain|recycling endosome|prepulse inhibition|Golgi-associated vesicle lumen|cellular response to copper ion|cellular response to manganese ion|hippocampal mossy fiber to CA3 synapse|cellular response to amyloid-beta|regulation of synaptic vesicle exocytosis hsa05010 Alzheimer disease BACE2 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.105725914 0.064232411 25825 beta-secretase 2 "GO:0004190,GO:0005515,GO:0005768,GO:0005783,GO:0005794,GO:0005802,GO:0005886,GO:0006508,GO:0006509,GO:0016020,GO:0016021,GO:0016486,GO:0031045,GO:0042593,GO:0042985,GO:0048143,GO:0050435" aspartic-type endopeptidase activity|protein binding|endosome|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|plasma membrane|proteolysis|membrane protein ectodomain proteolysis|membrane|integral component of membrane|peptide hormone processing|dense core granule|glucose homeostasis|negative regulation of amyloid precursor protein biosynthetic process|astrocyte activation|amyloid-beta metabolic process hsa05010 Alzheimer disease BACH1 1175.609984 1158.06476 1193.155208 1.030300938 0.043065792 0.902517713 1 10.0396944 10.7894801 571 BTB domain and CNC homolog 1 "GO:0000083,GO:0000117,GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006281,GO:0006355,GO:0006357,GO:0020037,GO:0045944,GO:0061418" "regulation of transcription involved in G1/S transition of mitotic cell cycle|regulation of transcription involved in G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|cytosol|DNA repair|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|heme binding|positive regulation of transcription by RNA polymerase II|regulation of transcription from RNA polymerase II promoter in response to hypoxia" TF_bZIP BACH2 144.9714406 144.1237475 145.8191336 1.011763406 0.016871965 0.99061487 1 0.419551637 0.442772171 60468 BTB domain and CNC homolog 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0051170,GO:0090721,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|import into nucleus|primary adaptive immune response involving T cells and B cells|sequence-specific double-stranded DNA binding" TF_bZIP BAD 1274.334864 1104.272094 1444.397635 1.308008817 0.387372266 0.253267245 1 60.07248754 81.96005048 572 BCL2 associated agonist of cell death "GO:0001836,GO:0001844,GO:0005515,GO:0005543,GO:0005739,GO:0005741,GO:0005829,GO:0006007,GO:0006915,GO:0006919,GO:0007283,GO:0008289,GO:0008625,GO:0008630,GO:0008656,GO:0009749,GO:0010508,GO:0010918,GO:0019050,GO:0019221,GO:0019901,GO:0019903,GO:0021987,GO:0030346,GO:0032024,GO:0032355,GO:0032570,GO:0033133,GO:0033574,GO:0034201,GO:0035774,GO:0042493,GO:0042542,GO:0042593,GO:0043065,GO:0043200,GO:0043280,GO:0043422,GO:0044342,GO:0045471,GO:0045579,GO:0045582,GO:0045862,GO:0046031,GO:0046034,GO:0046902,GO:0046931,GO:0050679,GO:0051384,GO:0051592,GO:0060139,GO:0071247,GO:0071260,GO:0071316,GO:0071396,GO:0071456,GO:0071889,GO:0090200,GO:0097191,GO:0097192,GO:0097193,GO:0097202,GO:1900740,GO:1901216,GO:1901423,GO:1902220,GO:1904710,GO:2000078,GO:2001244" release of cytochrome c from mitochondria|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|protein binding|phospholipid binding|mitochondrion|mitochondrial outer membrane|cytosol|glucose catabolic process|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|spermatogenesis|lipid binding|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|cysteine-type endopeptidase activator activity involved in apoptotic process|response to glucose|positive regulation of autophagy|positive regulation of mitochondrial membrane potential|suppression by virus of host apoptotic process|cytokine-mediated signaling pathway|protein kinase binding|protein phosphatase binding|cerebral cortex development|protein phosphatase 2B binding|positive regulation of insulin secretion|response to estradiol|response to progesterone|positive regulation of glucokinase activity|response to testosterone|response to oleic acid|positive regulation of insulin secretion involved in cellular response to glucose stimulus|response to drug|response to hydrogen peroxide|glucose homeostasis|positive regulation of apoptotic process|response to amino acid|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein kinase B binding|type B pancreatic cell proliferation|response to ethanol|positive regulation of B cell differentiation|positive regulation of T cell differentiation|positive regulation of proteolysis|ADP metabolic process|ATP metabolic process|regulation of mitochondrial membrane permeability|pore complex assembly|positive regulation of epithelial cell proliferation|response to glucocorticoid|response to calcium ion|positive regulation of apoptotic process by virus|cellular response to chromate|cellular response to mechanical stimulus|cellular response to nicotine|cellular response to lipid|cellular response to hypoxia|14-3-3 protein binding|positive regulation of release of cytochrome c from mitochondria|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of neuron death|response to benzene|positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|positive regulation of granulosa cell apoptotic process|positive regulation of type B pancreatic cell development|positive regulation of intrinsic apoptotic signaling pathway "hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04022,hsa04024,hsa04062,hsa04140,hsa04151,hsa04210,hsa04370,hsa04510,hsa04722,hsa04910,hsa04919,hsa05010,hsa05014,hsa05020,hsa05022,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05165,hsa05168,hsa05170,hsa05200,hsa05203,hsa05210,hsa05211,hsa05212,hsa05213,hsa05215,hsa05218,hsa05220,hsa05221,hsa05223,hsa05225" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Autophagy - animal|PI3K-Akt signaling pathway|Apoptosis|VEGF signaling pathway|Focal adhesion|Neurotrophin signaling pathway|Insulin signaling pathway|Thyroid hormone signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human papillomavirus infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Hepatocellular carcinoma BAG1 734.7813543 759.1870643 710.3756443 0.935705675 -0.095873292 0.800426629 1 10.06548339 9.824033386 573 BAG cochaperone 1 "GO:0000774,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0007166,GO:0016020,GO:0031072,GO:0031625,GO:0043066,GO:0050790,GO:0050821,GO:0051085,GO:0051087,GO:1900034" adenyl-nucleotide exchange factor activity|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|cell surface receptor signaling pathway|membrane|heat shock protein binding|ubiquitin protein ligase binding|negative regulation of apoptotic process|regulation of catalytic activity|protein stabilization|chaperone cofactor-dependent protein refolding|chaperone binding|regulation of cellular response to heat hsa04141 Protein processing in endoplasmic reticulum BAG2 278.0603251 284.1876711 271.932979 0.956878171 -0.063592841 0.902841487 1 5.220566917 5.210630099 9532 BAG cochaperone 2 "GO:0000774,GO:0005515,GO:0005829,GO:0005874,GO:0006457,GO:0010954,GO:0019538,GO:0030424,GO:0030425,GO:0031072,GO:0031397,GO:0031625,GO:0032091,GO:0032436,GO:0042802,GO:0044325,GO:0048156,GO:0050821,GO:0051087,GO:0101031,GO:1900034,GO:1901588,GO:1901800,GO:1904667" adenyl-nucleotide exchange factor activity|protein binding|cytosol|microtubule|protein folding|positive regulation of protein processing|protein metabolic process|axon|dendrite|heat shock protein binding|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|ion channel binding|tau protein binding|protein stabilization|chaperone binding|chaperone complex|regulation of cellular response to heat|dendritic microtubule|positive regulation of proteasomal protein catabolic process|negative regulation of ubiquitin protein ligase activity hsa04141 Protein processing in endoplasmic reticulum BAG3 840.8375721 869.8172649 811.8578792 0.933366021 -0.099485148 0.786935854 1 17.20155249 16.74694373 9531 BAG cochaperone 3 "GO:0000045,GO:0000774,GO:0001725,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0007420,GO:0008625,GO:0010664,GO:0016020,GO:0016235,GO:0021510,GO:0030018,GO:0031072,GO:0034605,GO:0034620,GO:0042307,GO:0043005,GO:0043066,GO:0044877,GO:0045296,GO:0045505,GO:0046716,GO:0046827,GO:0050790,GO:0050821,GO:0051087,GO:0061684,GO:0070842,GO:0071260,GO:0072321,GO:0097192,GO:0097201,GO:0098840,GO:0101031,GO:1900034,GO:1903215,GO:1905337" autophagosome assembly|adenyl-nucleotide exchange factor activity|stress fiber|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein folding|brain development|extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of striated muscle cell apoptotic process|membrane|aggresome|spinal cord development|Z disc|heat shock protein binding|cellular response to heat|cellular response to unfolded protein|positive regulation of protein import into nucleus|neuron projection|negative regulation of apoptotic process|protein-containing complex binding|cadherin binding|dynein intermediate chain binding|muscle cell cellular homeostasis|positive regulation of protein export from nucleus|regulation of catalytic activity|protein stabilization|chaperone binding|chaperone-mediated autophagy|aggresome assembly|cellular response to mechanical stimulus|chaperone-mediated protein transport|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of transcription from RNA polymerase II promoter in response to stress|protein transport along microtubule|chaperone complex|regulation of cellular response to heat|negative regulation of protein targeting to mitochondrion|positive regulation of aggrephagy BAG4 479.8274841 505.4480723 454.206896 0.898622274 -0.154213273 0.711941647 1 6.099395222 5.717153912 9530 BAG cochaperone 4 "GO:0000774,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0010763,GO:0016020,GO:0030838,GO:0031072,GO:0031625,GO:0033138,GO:0033209,GO:0043066,GO:0044877,GO:0045785,GO:0050821,GO:0051087,GO:0051496,GO:0051897,GO:0071356,GO:0071364,GO:0072659,GO:0090367,GO:0097178,GO:1900034,GO:1903215,GO:2001145" "adenyl-nucleotide exchange factor activity|RNA binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein folding|positive regulation of fibroblast migration|membrane|positive regulation of actin filament polymerization|heat shock protein binding|ubiquitin protein ligase binding|positive regulation of peptidyl-serine phosphorylation|tumor necrosis factor-mediated signaling pathway|negative regulation of apoptotic process|protein-containing complex binding|positive regulation of cell adhesion|protein stabilization|chaperone binding|positive regulation of stress fiber assembly|positive regulation of protein kinase B signaling|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|protein localization to plasma membrane|negative regulation of mRNA modification|ruffle assembly|regulation of cellular response to heat|negative regulation of protein targeting to mitochondrion|negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity" hsa04668 TNF signaling pathway BAG5 1011.025052 986.5372013 1035.512902 1.049644048 0.069900169 0.844876186 1 9.812378034 10.74316507 9529 BAG cochaperone 5 "GO:0000774,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006457,GO:0007030,GO:0010977,GO:0016020,GO:0016234,GO:0019901,GO:0031072,GO:0031397,GO:0031625,GO:0032435,GO:0048471,GO:0050821,GO:0051087,GO:0051438,GO:0051444,GO:0061084,GO:0070997,GO:0090083,GO:1900034,GO:1902176" adenyl-nucleotide exchange factor activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|protein folding|Golgi organization|negative regulation of neuron projection development|membrane|inclusion body|protein kinase binding|heat shock protein binding|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|perinuclear region of cytoplasm|protein stabilization|chaperone binding|regulation of ubiquitin-protein transferase activity|negative regulation of ubiquitin-protein transferase activity|negative regulation of protein refolding|neuron death|regulation of inclusion body assembly|regulation of cellular response to heat|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway BAG6 4823.989202 4589.630889 5058.347515 1.102125124 0.140288023 0.661916858 1 46.53625892 53.49809279 7917 BAG cochaperone 6 "GO:0001822,GO:0002429,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0006511,GO:0006915,GO:0007130,GO:0007283,GO:0007420,GO:0010498,GO:0016020,GO:0018393,GO:0030101,GO:0030154,GO:0030324,GO:0030433,GO:0031593,GO:0031625,GO:0032435,GO:0042771,GO:0043022,GO:0043231,GO:0045861,GO:0045995,GO:0050821,GO:0051787,GO:0061857,GO:0070059,GO:0070062,GO:0070628,GO:0071712,GO:0071816,GO:0071818,GO:1904294,GO:1904378,GO:1904379,GO:1990381" kidney development|immune response-activating cell surface receptor signaling pathway|signaling receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin organization|ubiquitin-dependent protein catabolic process|apoptotic process|synaptonemal complex assembly|spermatogenesis|brain development|proteasomal protein catabolic process|membrane|internal peptidyl-lysine acetylation|natural killer cell activation|cell differentiation|lung development|ubiquitin-dependent ERAD pathway|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|ribosome binding|intracellular membrane-bounded organelle|negative regulation of proteolysis|regulation of embryonic development|protein stabilization|misfolded protein binding|endoplasmic reticulum stress-induced pre-emptive quality control|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|extracellular exosome|proteasome binding|ER-associated misfolded protein catabolic process|tail-anchored membrane protein insertion into ER membrane|BAT3 complex|positive regulation of ERAD pathway|maintenance of unfolded protein involved in ERAD pathway|protein localization to cytosolic proteasome complex involved in ERAD pathway|ubiquitin-specific protease binding BAHCC1 279.9120877 276.0680234 283.756152 1.027848675 0.039627879 0.942447864 1 1.267162541 1.35855566 57597 BAH domain and coiled-coil containing 1 GO:0003682 chromatin binding BAHD1 729.9522717 664.7961593 795.1083842 1.196018318 0.258239486 0.491206637 1 6.42917323 8.020637505 22893 bromo adjacent homology domain containing 1 "GO:0003682,GO:0005515,GO:0005654,GO:0005677,GO:0005694,GO:0031507,GO:0045892" "chromatin binding|protein binding|nucleoplasm|chromatin silencing complex|chromosome|heterochromatin assembly|negative regulation of transcription, DNA-templated" BAIAP2 544.4216865 509.5078961 579.3354769 1.137049065 0.18529451 0.645603262 1 3.378030829 4.006440929 10458 BAR/IMD domain containing adaptor protein 2 "GO:0001726,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0007009,GO:0007409,GO:0008022,GO:0008093,GO:0008286,GO:0008360,GO:0009617,GO:0015629,GO:0030175,GO:0030838,GO:0032956,GO:0038096,GO:0042802,GO:0048010,GO:0051017,GO:0051764,GO:0070062,GO:0070064,GO:0098609,GO:0098641,GO:2000251" ruffle|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|adherens junction|plasma membrane organization|axonogenesis|protein C-terminus binding|cytoskeletal anchor activity|insulin receptor signaling pathway|regulation of cell shape|response to bacterium|actin cytoskeleton|filopodium|positive regulation of actin filament polymerization|regulation of actin cytoskeleton organization|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|vascular endothelial growth factor receptor signaling pathway|actin filament bundle assembly|actin crosslink formation|extracellular exosome|proline-rich region binding|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of actin cytoskeleton reorganization "hsa04520,hsa04810,hsa05130,hsa05135" Adherens junction|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Yersinia infection BAIAP2L1 1227.505113 1102.242182 1352.768044 1.227287493 0.295473241 0.386301579 1 15.31541235 19.60608732 55971 BAR/IMD domain containing adaptor protein 2 like 1 "GO:0003779,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0005912,GO:0007009,GO:0009617,GO:0015629,GO:0030838,GO:0046626,GO:0051017,GO:0051764,GO:0070062,GO:0070064,GO:0098609,GO:0098641,GO:2000251" actin binding|protein binding|nucleoplasm|cytosol|plasma membrane|adherens junction|plasma membrane organization|response to bacterium|actin cytoskeleton|positive regulation of actin filament polymerization|regulation of insulin receptor signaling pathway|actin filament bundle assembly|actin crosslink formation|extracellular exosome|proline-rich region binding|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of actin cytoskeleton reorganization hsa05130 Pathogenic Escherichia coli infection BAIAP3 16.58346994 22.3290313 10.83790858 0.485372985 -1.042834281 0.38652772 1 0.20438942 0.103478457 8938 BAI1 associated protein 3 "GO:0000149,GO:0001956,GO:0005509,GO:0005515,GO:0005543,GO:0005829,GO:0005886,GO:0006887,GO:0007186,GO:0019905,GO:0031045,GO:0031901,GO:0031902,GO:0032228,GO:0032588,GO:0035774,GO:0042147,GO:0055038,GO:0098793,GO:1905413,GO:1990502" "SNARE binding|positive regulation of neurotransmitter secretion|calcium ion binding|protein binding|phospholipid binding|cytosol|plasma membrane|exocytosis|G protein-coupled receptor signaling pathway|syntaxin binding|dense core granule|early endosome membrane|late endosome membrane|regulation of synaptic transmission, GABAergic|trans-Golgi network membrane|positive regulation of insulin secretion involved in cellular response to glucose stimulus|retrograde transport, endosome to Golgi|recycling endosome membrane|presynapse|regulation of dense core granule exocytosis|dense core granule maturation" hsa05202 Transcriptional misregulation in cancer BAK1 710.0903608 755.1272405 665.0534812 0.88071711 -0.1832494 0.628216207 1 16.76656326 15.40268435 578 BCL2 antagonist/killer 1 "GO:0001782,GO:0001783,GO:0001836,GO:0001974,GO:0002262,GO:0002352,GO:0003674,GO:0005515,GO:0005739,GO:0005741,GO:0005783,GO:0005829,GO:0006915,GO:0007420,GO:0007568,GO:0008053,GO:0008283,GO:0008285,GO:0008630,GO:0008635,GO:0009620,GO:0010046,GO:0010225,GO:0010248,GO:0010332,GO:0010524,GO:0010629,GO:0014070,GO:0016032,GO:0031018,GO:0031072,GO:0031100,GO:0031307,GO:0031334,GO:0032469,GO:0032471,GO:0033137,GO:0034620,GO:0034644,GO:0035108,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043065,GO:0044325,GO:0044346,GO:0044877,GO:0045471,GO:0045862,GO:0046872,GO:0046902,GO:0046930,GO:0046982,GO:0048597,GO:0051087,GO:0051400,GO:0051726,GO:0051881,GO:0060068,GO:0070059,GO:0070242,GO:0071260,GO:0090200,GO:0097136,GO:0097145,GO:0097190,GO:0097192,GO:0097202,GO:1900103,GO:1901030,GO:1902262,GO:1903896" B cell homeostasis|B cell apoptotic process|release of cytochrome c from mitochondria|blood vessel remodeling|myeloid cell homeostasis|B cell negative selection|molecular_function|protein binding|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|cytosol|apoptotic process|brain development|aging|mitochondrial fusion|cell population proliferation|negative regulation of cell population proliferation|intrinsic apoptotic signaling pathway in response to DNA damage|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|response to fungus|response to mycotoxin|response to UV-C|establishment or maintenance of transmembrane electrochemical gradient|response to gamma radiation|positive regulation of calcium ion transport into cytosol|negative regulation of gene expression|response to organic cyclic compound|viral process|endocrine pancreas development|heat shock protein binding|animal organ regeneration|integral component of mitochondrial outer membrane|positive regulation of protein-containing complex assembly|endoplasmic reticulum calcium ion homeostasis|negative regulation of endoplasmic reticulum calcium ion concentration|negative regulation of peptidyl-serine phosphorylation|cellular response to unfolded protein|cellular response to UV|limb morphogenesis|response to drug|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|ion channel binding|fibroblast apoptotic process|protein-containing complex binding|response to ethanol|positive regulation of proteolysis|metal ion binding|regulation of mitochondrial membrane permeability|pore complex|protein heterodimerization activity|post-embryonic camera-type eye morphogenesis|chaperone binding|BH domain binding|regulation of cell cycle|regulation of mitochondrial membrane potential|vagina development|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|thymocyte apoptotic process|cellular response to mechanical stimulus|positive regulation of release of cytochrome c from mitochondria|Bcl-2 family protein complex|BAK complex|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|activation of cysteine-type endopeptidase activity|positive regulation of endoplasmic reticulum unfolded protein response|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|apoptotic process involved in blood vessel morphogenesis|positive regulation of IRE1-mediated unfolded protein response "hsa01524,hsa04141,hsa04210,hsa04215,hsa05022,hsa05130,hsa05132,hsa05160,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05202,hsa05203,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Platinum drug resistance|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection|Hepatitis C|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer BAMBI 89.53213089 92.36099312 86.70326866 0.938743356 -0.091197303 0.912635128 1 2.766267576 2.70867558 25805 BMP and activin membrane bound inhibitor "GO:0005109,GO:0005114,GO:0005515,GO:0005737,GO:0005886,GO:0007179,GO:0008284,GO:0008360,GO:0010718,GO:0016021,GO:0016477,GO:0030512,GO:0030514,GO:0032092,GO:0045668,GO:0045893,GO:0090263" "frizzled binding|type II transforming growth factor beta receptor binding|protein binding|cytoplasm|plasma membrane|transforming growth factor beta receptor signaling pathway|positive regulation of cell population proliferation|regulation of cell shape|positive regulation of epithelial to mesenchymal transition|integral component of membrane|cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|positive regulation of protein binding|negative regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of canonical Wnt signaling pathway" "hsa04310,hsa04350" Wnt signaling pathway|TGF-beta signaling pathway BANF1 2463.557433 2654.109857 2273.005009 0.856409543 -0.223627224 0.483728083 1 81.96420801 73.21864279 8815 BAF nuclear assembly factor 1 "GO:0000793,GO:0003677,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0007059,GO:0007084,GO:0008022,GO:0009615,GO:0015074,GO:0019899,GO:0030261,GO:0042802,GO:0042803,GO:0045071,GO:0047485,GO:0051169,GO:0075713,GO:0097726" condensed chromosome|DNA binding|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|cytosol|chromosome segregation|mitotic nuclear envelope reassembly|protein C-terminus binding|response to virus|DNA integration|enzyme binding|chromosome condensation|identical protein binding|protein homodimerization activity|negative regulation of viral genome replication|protein N-terminus binding|nuclear transport|establishment of integrated proviral latency|LEM domain binding BANK1 13.97185114 12.17947162 15.76423066 1.294327961 0.372203218 0.812338614 1 0.175739963 0.237263424 55024 B cell scaffold protein with ankyrin repeats 1 "GO:0005102,GO:0009617,GO:0032715,GO:0042113,GO:0043410,GO:0045947,GO:0050731,GO:0050869,GO:0051898,GO:1990782" signaling receptor binding|response to bacterium|negative regulation of interleukin-6 production|B cell activation|positive regulation of MAPK cascade|negative regulation of translational initiation|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of B cell activation|negative regulation of protein kinase B signaling|protein tyrosine kinase binding BANP 328.5139296 331.8906017 325.1372575 0.979651897 -0.029658893 0.955676998 1 2.597201504 2.653953805 54971 BTG3 associated nuclear protein "GO:0003677,GO:0005515,GO:0005654,GO:0006325,GO:0007049,GO:0007275,GO:0016604,GO:0034504,GO:0042177,GO:0045893,GO:1901796" "DNA binding|protein binding|nucleoplasm|chromatin organization|cell cycle|multicellular organism development|nuclear body|protein localization to nucleus|negative regulation of protein catabolic process|positive regulation of transcription, DNA-templated|regulation of signal transduction by p53 class mediator" BAP1 2451.594213 2173.020728 2730.167698 1.256392846 0.329287634 0.302405948 1 30.53713483 40.01931691 8314 BRCA1 associated protein 1 "GO:0001558,GO:0003682,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006511,GO:0008233,GO:0008234,GO:0008285,GO:0010035,GO:0016579,GO:0018215,GO:0035517,GO:0035520,GO:0035522,GO:0045892,GO:0050727,GO:0051726,GO:0061519,GO:0071108,GO:1900015,GO:1903955" "regulation of cell growth|chromatin binding|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|peptidase activity|cysteine-type peptidase activity|negative regulation of cell population proliferation|response to inorganic substance|protein deubiquitination|protein phosphopantetheinylation|PR-DUB complex|monoubiquitinated protein deubiquitination|monoubiquitinated histone H2A deubiquitination|negative regulation of transcription, DNA-templated|regulation of inflammatory response|regulation of cell cycle|macrophage homeostasis|protein K48-linked deubiquitination|regulation of cytokine production involved in inflammatory response|positive regulation of protein targeting to mitochondrion" BARD1 388.1818099 335.9504255 440.4131942 1.310946975 0.390609333 0.37261868 1 3.040511775 4.157648263 580 BRCA1 associated RING domain 1 "GO:0000151,GO:0000729,GO:0001894,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006303,GO:0006974,GO:0007050,GO:0016567,GO:0016579,GO:0016607,GO:0019900,GO:0031436,GO:0031441,GO:0036464,GO:0042325,GO:0042803,GO:0043065,GO:0043066,GO:0045732,GO:0046826,GO:0046872,GO:0046982,GO:0070531,GO:0085020,GO:1901796" ubiquitin ligase complex|DNA double-strand break processing|tissue homeostasis|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA replication|double-strand break repair via nonhomologous end joining|cellular response to DNA damage stimulus|cell cycle arrest|protein ubiquitination|protein deubiquitination|nuclear speck|kinase binding|BRCA1-BARD1 complex|negative regulation of mRNA 3'-end processing|cytoplasmic ribonucleoprotein granule|regulation of phosphorylation|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of protein catabolic process|negative regulation of protein export from nucleus|metal ion binding|protein heterodimerization activity|BRCA1-A complex|protein K6-linked ubiquitination|regulation of signal transduction by p53 class mediator hsa03440 Homologous recombination BARX2 6.552676467 10.14955968 2.95579325 0.291223791 -1.779799875 0.306941875 1 0.250628665 0.076133101 8538 BARX homeobox 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0001502,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005794,GO:0005829,GO:0006357,GO:0014902,GO:0015629,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cartilage condensation|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|myotube differentiation|actin cytoskeleton|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" Homeobox BASP1 3625.47516 3482.313927 3768.636393 1.0822219 0.113996341 0.720622755 1 93.71249498 105.7863782 10409 brain abundant membrane attached signal protein 1 "GO:0000785,GO:0000976,GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0005886,GO:0007356,GO:0008180,GO:0008406,GO:0016363,GO:0016605,GO:0016607,GO:0019904,GO:0021762,GO:0030054,GO:0030426,GO:0031982,GO:0045892,GO:0060231,GO:0060421,GO:0060539,GO:0070062,GO:0072075,GO:0072112,GO:2001076" "chromatin|transcription regulatory region sequence-specific DNA binding|transcription corepressor activity|protein binding|nucleus|cytoplasm|cytoskeleton|plasma membrane|thorax and anterior abdomen determination|COP9 signalosome|gonad development|nuclear matrix|PML body|nuclear speck|protein domain specific binding|substantia nigra development|cell junction|growth cone|vesicle|negative regulation of transcription, DNA-templated|mesenchymal to epithelial transition|positive regulation of heart growth|diaphragm development|extracellular exosome|metanephric mesenchyme development|glomerular visceral epithelial cell differentiation|positive regulation of metanephric ureteric bud development" BATF2 28.03277694 30.44867905 25.61687483 0.841313174 -0.249285159 0.834663052 1 0.679347215 0.596163549 116071 basic leucine zipper ATF-like transcription factor 2 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042832,GO:0043011" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|defense response to protozoan|myeloid dendritic cell differentiation" hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer BATF3 98.95152595 96.420817 101.4822349 1.052493 0.073810638 0.928869369 1 3.866487909 4.244746921 55509 basic leucine zipper ATF-like transcription factor 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0009615,GO:0043011,GO:0097028,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|response to virus|myeloid dendritic cell differentiation|dendritic cell differentiation|sequence-specific double-stranded DNA binding" hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer TF_bZIP BAX 1265.337832 1230.126634 1300.54903 1.057248087 0.08031395 0.814735496 1 69.68856193 76.85185245 581 "BCL2 associated X, apoptosis regulator" "GO:0001541,GO:0001764,GO:0001777,GO:0001782,GO:0001783,GO:0001822,GO:0001836,GO:0001844,GO:0001974,GO:0002262,GO:0002352,GO:0002358,GO:0002904,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005739,GO:0005741,GO:0005757,GO:0005783,GO:0005789,GO:0005829,GO:0006367,GO:0006687,GO:0006808,GO:0006915,GO:0006919,GO:0006977,GO:0007281,GO:0008053,GO:0008289,GO:0008625,GO:0008630,GO:0008635,GO:0008637,GO:0009566,GO:0009636,GO:0009651,GO:0010248,GO:0010332,GO:0010917,GO:0015267,GO:0016020,GO:0016032,GO:0021854,GO:0021987,GO:0030544,GO:0031334,GO:0032091,GO:0032469,GO:0032471,GO:0032976,GO:0033137,GO:0033599,GO:0034620,GO:0034644,GO:0035234,GO:0042475,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043524,GO:0043525,GO:0043653,GO:0045136,GO:0046666,GO:0046930,GO:0046982,GO:0048087,GO:0048147,GO:0048515,GO:0048597,GO:0048678,GO:0048873,GO:0051087,GO:0051281,GO:0051402,GO:0051434,GO:0051881,GO:0060011,GO:0060041,GO:0060058,GO:0060068,GO:0070059,GO:0070062,GO:0070242,GO:0070584,GO:0071944,GO:0072332,GO:0090200,GO:0097136,GO:0097144,GO:0097145,GO:0097190,GO:0097191,GO:0097192,GO:0097193,GO:0097296,GO:0098586,GO:1900103,GO:1901030,GO:1902262,GO:1902263,GO:1902445,GO:1902512,GO:1903896,GO:1990117,GO:2001234,GO:2001244" "ovarian follicle development|neuron migration|T cell homeostatic proliferation|B cell homeostasis|B cell apoptotic process|kidney development|release of cytochrome c from mitochondria|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|blood vessel remodeling|myeloid cell homeostasis|B cell negative selection|B cell homeostatic proliferation|positive regulation of B cell apoptotic process|protein binding|nucleus|nuclear envelope|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial permeability transition pore complex|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|transcription initiation from RNA polymerase II promoter|glycosphingolipid metabolic process|regulation of nitrogen utilization|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|germ cell development|mitochondrial fusion|lipid binding|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|apoptotic mitochondrial changes|fertilization|response to toxic substance|response to salt stress|establishment or maintenance of transmembrane electrochemical gradient|response to gamma radiation|negative regulation of mitochondrial membrane potential|channel activity|membrane|viral process|hypothalamus development|cerebral cortex development|Hsp70 protein binding|positive regulation of protein-containing complex assembly|negative regulation of protein binding|endoplasmic reticulum calcium ion homeostasis|negative regulation of endoplasmic reticulum calcium ion concentration|release of matrix enzymes from mitochondria|negative regulation of peptidyl-serine phosphorylation|regulation of mammary gland epithelial cell proliferation|cellular response to unfolded protein|cellular response to UV|ectopic germ cell programmed cell death|odontogenesis of dentin-containing tooth|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|mitochondrial fragmentation involved in apoptotic process|development of secondary sexual characteristics|retinal cell programmed cell death|pore complex|protein heterodimerization activity|positive regulation of developmental pigmentation|negative regulation of fibroblast proliferation|spermatid differentiation|post-embryonic camera-type eye morphogenesis|response to axon injury|homeostasis of number of cells within a tissue|chaperone binding|positive regulation of release of sequestered calcium ion into cytosol|neuron apoptotic process|BH3 domain binding|regulation of mitochondrial membrane potential|Sertoli cell proliferation|retina development in camera-type eye|positive regulation of apoptotic process involved in mammary gland involution|vagina development|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|extracellular exosome|thymocyte apoptotic process|mitochondrion morphogenesis|cell periphery|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of release of cytochrome c from mitochondria|Bcl-2 family protein complex|BAX complex|BAK complex|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cellular response to virus|positive regulation of endoplasmic reticulum unfolded protein response|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|apoptotic process involved in blood vessel morphogenesis|apoptotic process involved in embryonic digit morphogenesis|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death|positive regulation of apoptotic DNA fragmentation|positive regulation of IRE1-mediated unfolded protein response|B cell receptor apoptotic signaling pathway|negative regulation of apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway" "hsa01521,hsa01522,hsa01524,hsa04071,hsa04115,hsa04141,hsa04210,hsa04211,hsa04215,hsa04217,hsa04722,hsa04932,hsa04933,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05131,hsa05132,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05202,hsa05203,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|Sphingolipid signaling pathway|p53 signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Longevity regulating pathway|Apoptosis - multiple species|Necroptosis|Neurotrophin signaling pathway|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer BAZ1A 1424.054231 1606.675298 1241.433165 0.772672093 -0.372071803 0.265033118 1 13.82004685 11.13834515 11177 bromodomain adjacent to zinc finger domain 1A "GO:0000228,GO:0004402,GO:0005515,GO:0006261,GO:0006338,GO:0006357,GO:0008623,GO:0016573,GO:0016590,GO:0046872" nuclear chromosome|histone acetyltransferase activity|protein binding|DNA-dependent DNA replication|chromatin remodeling|regulation of transcription by RNA polymerase II|CHRAC|histone acetylation|ACF complex|metal ion binding BAZ1B 4550.467725 4481.0306 4619.904849 1.030991587 0.04403256 0.891116699 1 34.37570309 36.96771783 9031 bromodomain adjacent to zinc finger domain 1B "GO:0000793,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005654,GO:0005721,GO:0006333,GO:0006338,GO:0006357,GO:0006974,GO:0008270,GO:0016572,GO:0016604,GO:0018108,GO:0035173,GO:0042393,GO:0043596,GO:0045815" "condensed chromosome|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|pericentric heterochromatin|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|zinc ion binding|histone phosphorylation|nuclear body|peptidyl-tyrosine phosphorylation|histone kinase activity|histone binding|nuclear replication fork|positive regulation of gene expression, epigenetic" BAZ2A 4612.831101 4197.857885 5027.804318 1.197707129 0.260275175 0.416169081 1 22.47428042 28.07710718 11176 bromodomain adjacent to zinc finger domain 2A "GO:0000183,GO:0001164,GO:0001188,GO:0003723,GO:0005515,GO:0005677,GO:0005730,GO:0005829,GO:0006306,GO:0006338,GO:0006351,GO:0006355,GO:0016575,GO:0016607,GO:0016922,GO:0033553,GO:0042393,GO:0046872,GO:0070577" "rDNA heterochromatin assembly|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I preinitiation complex assembly|RNA binding|protein binding|chromatin silencing complex|nucleolus|cytosol|DNA methylation|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|histone deacetylation|nuclear speck|nuclear receptor binding|rDNA heterochromatin|histone binding|metal ion binding|lysine-acetylated histone binding" BAZ2B 715.5296041 689.1551025 741.9041057 1.076541555 0.106404009 0.779907316 1 3.148978234 3.536033631 29994 bromodomain adjacent to zinc finger domain 2B "GO:0003677,GO:0005515,GO:0005634,GO:0006338,GO:0006357,GO:0046872" DNA binding|protein binding|nucleus|chromatin remodeling|regulation of transcription by RNA polymerase II|metal ion binding BBC3 109.4452601 106.5703767 112.3201435 1.053952768 0.075810215 0.92237869 1 2.271638729 2.49733235 27113 BCL2 binding component 3 "GO:0001836,GO:0005515,GO:0005739,GO:0005764,GO:0006915,GO:0006919,GO:0051117,GO:0070059,GO:0090200,GO:0097194,GO:1900740,GO:2001244" release of cytochrome c from mitochondria|protein binding|mitochondrion|lysosome|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|ATPase binding|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of release of cytochrome c from mitochondria|execution phase of apoptosis|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway "hsa01524,hsa04115,hsa04210,hsa04215,hsa04390,hsa05016,hsa05162,hsa05200,hsa05210" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Hippo signaling pathway|Huntington disease|Measles|Pathways in cancer|Colorectal cancer BBIP1 221.742393 206.0360616 237.4487244 1.152461965 0.204719138 0.699819447 1 3.946671584 4.744315035 92482 BBSome interacting protein 1 "GO:0005515,GO:0005737,GO:0005829,GO:0015031,GO:0034464,GO:0060271,GO:0097500" protein binding|cytoplasm|cytosol|protein transport|BBSome|cilium assembly|receptor localization to non-motile cilium BBLN 871.940703 1143.855376 600.0260297 0.524564593 -0.930807664 0.010403414 0.432539484 65.90698468 36.0617124 79095 bublin coiled coil protein BBOF1 74.17145778 86.27125731 62.07165824 0.719494072 -0.474945294 0.531366126 1 0.942073057 0.707013543 80127 basal body orientation factor 1 "GO:0005737,GO:0036064,GO:0044458" cytoplasm|ciliary basal body|motile cilium assembly BBS1 473.3962955 469.9246134 476.8679776 1.014775485 0.021160573 0.964833231 1 7.066515401 7.479821032 582 Bardet-Biedl syndrome 1 "GO:0001103,GO:0005113,GO:0005119,GO:0005515,GO:0005813,GO:0005829,GO:0005930,GO:0007601,GO:0007608,GO:0034464,GO:0036064,GO:0043001,GO:0045494,GO:0050896,GO:0060170,GO:0060271,GO:0061512,GO:1905515" RNA polymerase II repressing transcription factor binding|patched binding|smoothened binding|protein binding|centrosome|cytosol|axoneme|visual perception|sensory perception of smell|BBSome|ciliary basal body|Golgi to plasma membrane protein transport|photoreceptor cell maintenance|response to stimulus|ciliary membrane|cilium assembly|protein localization to cilium|non-motile cilium assembly BBS10 418.3902349 414.1020351 422.6784347 1.020710837 0.029574214 0.950898031 1 5.878028928 6.258213489 79738 Bardet-Biedl syndrome 10 "GO:0001103,GO:0005515,GO:0005524,GO:0005929,GO:0007601,GO:0043254,GO:0045494,GO:0050896,GO:0051131,GO:1905515" RNA polymerase II repressing transcription factor binding|protein binding|ATP binding|cilium|visual perception|regulation of protein-containing complex assembly|photoreceptor cell maintenance|response to stimulus|chaperone-mediated protein complex assembly|non-motile cilium assembly BBS12 100.9369006 97.43577296 104.4380282 1.071865342 0.100123673 0.896437686 1 1.382290803 1.5454522 166379 Bardet-Biedl syndrome 12 "GO:0005515,GO:0005524,GO:0005929,GO:0042073,GO:0042755,GO:0045494,GO:0045599,GO:0051131" protein binding|ATP binding|cilium|intraciliary transport|eating behavior|photoreceptor cell maintenance|negative regulation of fat cell differentiation|chaperone-mediated protein complex assembly BBS2 1185.381718 1051.494383 1319.269054 1.254661056 0.327297676 0.339745039 1 18.26285359 23.90072006 583 Bardet-Biedl syndrome 2 "GO:0001103,GO:0005515,GO:0005829,GO:0005902,GO:0007288,GO:0007601,GO:0008104,GO:0010629,GO:0014824,GO:0016020,GO:0021756,GO:0021766,GO:0021987,GO:0030534,GO:0031514,GO:0032402,GO:0032420,GO:0033365,GO:0034464,GO:0036064,GO:0038108,GO:0040015,GO:0040018,GO:0042311,GO:0043001,GO:0043005,GO:0045444,GO:0045494,GO:0048854,GO:0051216,GO:0060170,GO:0060271,GO:0060296,GO:1905515" RNA polymerase II repressing transcription factor binding|protein binding|cytosol|microvillus|sperm axoneme assembly|visual perception|protein localization|negative regulation of gene expression|artery smooth muscle contraction|membrane|striatum development|hippocampus development|cerebral cortex development|adult behavior|motile cilium|melanosome transport|stereocilium|protein localization to organelle|BBSome|ciliary basal body|negative regulation of appetite by leptin-mediated signaling pathway|negative regulation of multicellular organism growth|positive regulation of multicellular organism growth|vasodilation|Golgi to plasma membrane protein transport|neuron projection|fat cell differentiation|photoreceptor cell maintenance|brain morphogenesis|cartilage development|ciliary membrane|cilium assembly|regulation of cilium beat frequency involved in ciliary motility|non-motile cilium assembly BBS4 486.1965681 570.4052542 401.987882 0.704740847 -0.504835259 0.220087033 1 10.3507753 7.608836543 585 Bardet-Biedl syndrome 4 "GO:0000226,GO:0000242,GO:0000281,GO:0001103,GO:0001843,GO:0001895,GO:0001947,GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0007098,GO:0007286,GO:0007601,GO:0007608,GO:0015031,GO:0016358,GO:0019216,GO:0021756,GO:0021766,GO:0021987,GO:0030534,GO:0030674,GO:0031514,GO:0032402,GO:0032465,GO:0033365,GO:0034451,GO:0034452,GO:0034454,GO:0034464,GO:0035869,GO:0036064,GO:0038108,GO:0043014,GO:0045444,GO:0045494,GO:0045724,GO:0046548,GO:0046907,GO:0048487,GO:0048854,GO:0050893,GO:0051457,GO:0060170,GO:0060271,GO:0060296,GO:0061512,GO:0071539,GO:0097730,GO:1905515" microtubule cytoskeleton organization|pericentriolar material|mitotic cytokinesis|RNA polymerase II repressing transcription factor binding|neural tube closure|retina homeostasis|heart looping|protein binding|nucleus|centrosome|centriole|cytosol|cilium|centrosome cycle|spermatid development|visual perception|sensory perception of smell|protein transport|dendrite development|regulation of lipid metabolic process|striatum development|hippocampus development|cerebral cortex development|adult behavior|protein-macromolecule adaptor activity|motile cilium|melanosome transport|regulation of cytokinesis|protein localization to organelle|centriolar satellite|dynactin binding|microtubule anchoring at centrosome|BBSome|ciliary transition zone|ciliary basal body|negative regulation of appetite by leptin-mediated signaling pathway|alpha-tubulin binding|fat cell differentiation|photoreceptor cell maintenance|positive regulation of cilium assembly|retinal rod cell development|intracellular transport|beta-tubulin binding|brain morphogenesis|sensory processing|maintenance of protein location in nucleus|ciliary membrane|cilium assembly|regulation of cilium beat frequency involved in ciliary motility|protein localization to cilium|protein localization to centrosome|non-motile cilium|non-motile cilium assembly BBS5 225.9358288 223.290313 228.5813446 1.023695751 0.033787 0.957219106 1 3.57988814 3.822577392 129880 Bardet-Biedl syndrome 5 "GO:0001103,GO:0001947,GO:0005515,GO:0005829,GO:0005930,GO:0007601,GO:0015031,GO:0032266,GO:0032402,GO:0034451,GO:0034464,GO:0036064,GO:0044458,GO:0046907,GO:0050896,GO:0060170,GO:0060271" RNA polymerase II repressing transcription factor binding|heart looping|protein binding|cytosol|axoneme|visual perception|protein transport|phosphatidylinositol-3-phosphate binding|melanosome transport|centriolar satellite|BBSome|ciliary basal body|motile cilium assembly|intracellular transport|response to stimulus|ciliary membrane|cilium assembly BBS7 520.4217635 451.6554059 589.1881211 1.304508068 0.383505867 0.343614795 1 5.314766024 7.231807365 55212 Bardet-Biedl syndrome 7 "GO:0001103,GO:0001654,GO:0001750,GO:0001947,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0005930,GO:0006357,GO:0007224,GO:0007368,GO:0007420,GO:0007601,GO:0008104,GO:0015031,GO:0016020,GO:0032402,GO:0032436,GO:0034464,GO:0036064,GO:0043005,GO:0045444,GO:0046907,GO:0048546,GO:0051877,GO:0060170,GO:0060173,GO:0060271,GO:1903929,GO:1905515" RNA polymerase II repressing transcription factor binding|eye development|photoreceptor outer segment|heart looping|protein binding|nucleus|centrosome|cytosol|axoneme|regulation of transcription by RNA polymerase II|smoothened signaling pathway|determination of left/right symmetry|brain development|visual perception|protein localization|protein transport|membrane|melanosome transport|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|BBSome|ciliary basal body|neuron projection|fat cell differentiation|intracellular transport|digestive tract morphogenesis|pigment granule aggregation in cell center|ciliary membrane|limb development|cilium assembly|primary palate development|non-motile cilium assembly BBS9 313.5271224 317.6812181 309.3730268 0.973847395 -0.038232379 0.941853261 1 1.862634057 1.892057699 27241 Bardet-Biedl syndrome 9 "GO:0000242,GO:0003674,GO:0005515,GO:0005829,GO:0005929,GO:0007601,GO:0015031,GO:0016020,GO:0034451,GO:0034464,GO:0035869,GO:0045444,GO:0050896,GO:0060170,GO:0060271,GO:0061512" pericentriolar material|molecular_function|protein binding|cytosol|cilium|visual perception|protein transport|membrane|centriolar satellite|BBSome|ciliary transition zone|fat cell differentiation|response to stimulus|ciliary membrane|cilium assembly|protein localization to cilium BBX 3615.098955 3311.801325 3918.396585 1.18316173 0.242647293 0.445882435 1 16.03854023 19.79360418 56987 BBX high mobility group box domain containing "GO:0000785,GO:0000977,GO:0000981,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0060348,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|bone development|sequence-specific double-stranded DNA binding" BCAM 528.9328446 427.2964627 630.5692266 1.47571834 0.561417391 0.16380108 1 8.822282276 13.58001825 4059 basal cell adhesion molecule (Lutheran blood group) "GO:0004888,GO:0005055,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007155,GO:0007160,GO:0007165,GO:0008022,GO:0009897,GO:0043236,GO:0062023,GO:0070062" transmembrane signaling receptor activity|laminin receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|cell adhesion|cell-matrix adhesion|signal transduction|protein C-terminus binding|external side of plasma membrane|laminin binding|collagen-containing extracellular matrix|extracellular exosome BCAN 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.057985267 0 63827 brevican "GO:0001501,GO:0005515,GO:0005540,GO:0005576,GO:0005796,GO:0007155,GO:0007417,GO:0021766,GO:0030198,GO:0030206,GO:0030207,GO:0030208,GO:0030246,GO:0031012,GO:0031225,GO:0043202,GO:0060074,GO:0098978" skeletal system development|protein binding|hyaluronic acid binding|extracellular region|Golgi lumen|cell adhesion|central nervous system development|hippocampus development|extracellular matrix organization|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|carbohydrate binding|extracellular matrix|anchored component of membrane|lysosomal lumen|synapse maturation|glutamatergic synapse BCAP29 9.49362394 9.134603715 9.852644165 1.078606634 0.109168812 1 1 0.09497751 0.106856218 55973 B cell receptor associated protein 29 "GO:0001649,GO:0005789,GO:0006886,GO:0006888,GO:0006915,GO:0016020,GO:0016021,GO:0070973" osteoblast differentiation|endoplasmic reticulum membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|apoptotic process|membrane|integral component of membrane|protein localization to endoplasmic reticulum exit site BCAP31 4526.452956 4422.163154 4630.742758 1.047166872 0.066491362 0.835815948 1 109.9494174 120.0949531 10134 B cell receptor associated protein 31 "GO:0002474,GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0005887,GO:0006626,GO:0006888,GO:0006915,GO:0007204,GO:0007283,GO:0016020,GO:0016032,GO:0030136,GO:0032471,GO:0032580,GO:0033116,GO:0034976,GO:0035584,GO:0042288,GO:0043280,GO:0044233,GO:0044877,GO:0051561,GO:0070973,GO:0071556,GO:0097038,GO:1903071,GO:1904154,GO:2001244" "antigen processing and presentation of peptide antigen via MHC class I|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cytosol|integral component of plasma membrane|protein targeting to mitochondrion|endoplasmic reticulum to Golgi vesicle-mediated transport|apoptotic process|positive regulation of cytosolic calcium ion concentration|spermatogenesis|membrane|viral process|clathrin-coated vesicle|negative regulation of endoplasmic reticulum calcium ion concentration|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|response to endoplasmic reticulum stress|calcium-mediated signaling using intracellular calcium source|MHC class I protein binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|mitochondria-associated endoplasmic reticulum membrane|protein-containing complex binding|positive regulation of mitochondrial calcium ion concentration|protein localization to endoplasmic reticulum exit site|integral component of lumenal side of endoplasmic reticulum membrane|perinuclear endoplasmic reticulum|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of retrograde protein transport, ER to cytosol|positive regulation of intrinsic apoptotic signaling pathway" "hsa04141,hsa05165" Protein processing in endoplasmic reticulum|Human papillomavirus infection BCAR1 1622.232672 1717.305498 1527.159846 0.889276746 -0.169295634 0.606987133 1 15.28567051 14.17873089 9564 "BCAR1 scaffold protein, Cas family member" "GO:0001558,GO:0001726,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0007015,GO:0007155,GO:0007169,GO:0007173,GO:0007186,GO:0007229,GO:0008286,GO:0010595,GO:0015629,GO:0016477,GO:0017124,GO:0019901,GO:0030027,GO:0030335,GO:0030424,GO:0035729,GO:0042981,GO:0048008,GO:0048010,GO:0048011,GO:0048012,GO:0050851,GO:0050852,GO:0050853,GO:0051301,GO:0060326,GO:0086100,GO:0090527" regulation of cell growth|ruffle|protein binding|cytoplasm|cytosol|plasma membrane|focal adhesion|actin filament organization|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|integrin-mediated signaling pathway|insulin receptor signaling pathway|positive regulation of endothelial cell migration|actin cytoskeleton|cell migration|SH3 domain binding|protein kinase binding|lamellipodium|positive regulation of cell migration|axon|cellular response to hepatocyte growth factor stimulus|regulation of apoptotic process|platelet-derived growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|hepatocyte growth factor receptor signaling pathway|antigen receptor-mediated signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|cell division|cell chemotaxis|endothelin receptor signaling pathway|actin filament reorganization "hsa04015,hsa04062,hsa04510,hsa04670,hsa04810,hsa04935,hsa05100,hsa05131,hsa05135,hsa05163" "Rap1 signaling pathway|Chemokine signaling pathway|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Growth hormone synthesis, secretion and action|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Human cytomegalovirus infection" BCAR3 4264.429283 4459.716525 4069.14204 0.912421679 -0.132227369 0.679008503 1 47.66172379 45.36085907 8412 "BCAR3 adaptor protein, NSP family member" "GO:0001784,GO:0002089,GO:0005085,GO:0005515,GO:0005737,GO:0005925,GO:0007165,GO:0007264,GO:0008286,GO:0016020,GO:0019900,GO:0033138,GO:0042493,GO:0043410,GO:0043547,GO:0045740,GO:0045742,GO:0086100" phosphotyrosine residue binding|lens morphogenesis in camera-type eye|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|focal adhesion|signal transduction|small GTPase mediated signal transduction|insulin receptor signaling pathway|membrane|kinase binding|positive regulation of peptidyl-serine phosphorylation|response to drug|positive regulation of MAPK cascade|positive regulation of GTPase activity|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor signaling pathway|endothelin receptor signaling pathway BCAS2 737.2714853 794.7105232 679.8324474 0.855446641 -0.225250227 0.547698374 1 31.56806622 28.1680533 10286 BCAS2 pre-mRNA processing factor "GO:0000375,GO:0000398,GO:0000974,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0005681,GO:0005730,GO:0005813,GO:0008380,GO:0016607,GO:0071007,GO:0071013" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|Prp19 complex|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|spliceosomal complex|nucleolus|centrosome|RNA splicing|nuclear speck|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome BCAS3 666.1354929 646.5269519 685.7440339 1.060658078 0.084959652 0.827190897 1 5.275384131 5.836405017 54828 BCAS3 microtubule associated cell migration factor "GO:0001525,GO:0003682,GO:0005515,GO:0005634,GO:0005737,GO:0005881,GO:0007030,GO:0008134,GO:0010595,GO:0010698,GO:0031023,GO:0031252,GO:0034260,GO:0035035,GO:0035148,GO:0035257,GO:0035327,GO:0042393,GO:0042594,GO:0043085,GO:0043547,GO:0045111,GO:0045944,GO:0048487,GO:0051491,GO:0051895,GO:0071391,GO:0090316,GO:0090630,GO:2000114,GO:2000251" angiogenesis|chromatin binding|protein binding|nucleus|cytoplasm|cytoplasmic microtubule|Golgi organization|transcription factor binding|positive regulation of endothelial cell migration|acetyltransferase activator activity|microtubule organizing center organization|cell leading edge|negative regulation of GTPase activity|histone acetyltransferase binding|tube formation|nuclear hormone receptor binding|transcriptionally active chromatin|histone binding|response to starvation|positive regulation of catalytic activity|positive regulation of GTPase activity|intermediate filament cytoskeleton|positive regulation of transcription by RNA polymerase II|beta-tubulin binding|positive regulation of filopodium assembly|negative regulation of focal adhesion assembly|cellular response to estrogen stimulus|positive regulation of intracellular protein transport|activation of GTPase activity|regulation of establishment of cell polarity|positive regulation of actin cytoskeleton reorganization BCAS4 520.9980272 524.7322356 517.2638187 0.985767185 -0.020681139 0.964386623 1 7.718802379 7.936704457 55653 breast carcinoma amplified sequence 4 GO:0031083 BLOC-1 complex BCAT1 2808.833974 3559.450581 2058.217366 0.578240186 -0.790259219 0.01348798 0.519363864 14.26441011 8.603556535 586 branched chain amino acid transaminase 1 "GO:0000082,GO:0004084,GO:0005739,GO:0005829,GO:0009082,GO:0009083,GO:0009098,GO:0009099,GO:0042802,GO:0052654,GO:0052655,GO:0052656" G1/S transition of mitotic cell cycle|branched-chain-amino-acid transaminase activity|mitochondrion|cytosol|branched-chain amino acid biosynthetic process|branched-chain amino acid catabolic process|leucine biosynthetic process|valine biosynthetic process|identical protein binding|L-leucine transaminase activity|L-valine transaminase activity|L-isoleucine transaminase activity "hsa00270,hsa00280,hsa00290,hsa00770" "Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation|Valine, leucine and isoleucine biosynthesis|Pantothenate and CoA biosynthesis" BCAT2 342.9459998 375.5337083 310.3582912 0.826445894 -0.275007723 0.54666444 1 8.668850283 7.472946248 587 branched chain amino acid transaminase 2 "GO:0004084,GO:0005515,GO:0005739,GO:0005759,GO:0009082,GO:0009083,GO:0009098,GO:0009099,GO:0052654,GO:0052655,GO:0052656" branched-chain-amino-acid transaminase activity|protein binding|mitochondrion|mitochondrial matrix|branched-chain amino acid biosynthetic process|branched-chain amino acid catabolic process|leucine biosynthetic process|valine biosynthetic process|L-leucine transaminase activity|L-valine transaminase activity|L-isoleucine transaminase activity "hsa00270,hsa00280,hsa00290,hsa00770" "Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation|Valine, leucine and isoleucine biosynthesis|Pantothenate and CoA biosynthesis" BCCIP 801.1718956 886.0565604 716.2872308 0.808398993 -0.306860571 0.403859349 1 13.3837277 11.28544751 56647 BRCA2 and CDKN1A interacting protein "GO:0000079,GO:0000226,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0006281,GO:0007052,GO:0019207,GO:0019908,GO:0034453,GO:0061101,GO:0090307,GO:0097431" regulation of cyclin-dependent protein serine/threonine kinase activity|microtubule cytoskeleton organization|RNA binding|protein binding|nucleus|nucleoplasm|centrosome|centriole|cytosol|DNA repair|mitotic spindle organization|kinase regulator activity|nuclear cyclin-dependent protein kinase holoenzyme complex|microtubule anchoring|neuroendocrine cell differentiation|mitotic spindle assembly|mitotic spindle pole BCDIN3D 98.09987352 105.5554207 90.64432632 0.85873682 -0.219712043 0.758058286 1 1.657163572 1.484367347 144233 BCDIN3 domain containing RNA methyltransferase "GO:0001510,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008171,GO:0008173,GO:0008175,GO:0010586,GO:0030488,GO:0061715,GO:2000632" RNA methylation|protein binding|nucleoplasm|cytoplasm|cytosol|O-methyltransferase activity|RNA methyltransferase activity|tRNA methyltransferase activity|miRNA metabolic process|tRNA methylation|miRNA 2'-O-methylation|negative regulation of pre-miRNA processing BCHE 81.06830869 86.27125731 75.86536007 0.879381644 -0.185438677 0.812323272 1 1.816771242 1.66645493 590 butyrylcholinesterase "GO:0001540,GO:0003824,GO:0003990,GO:0004104,GO:0005515,GO:0005576,GO:0005641,GO:0005788,GO:0007612,GO:0008285,GO:0014016,GO:0016020,GO:0019695,GO:0019899,GO:0033265,GO:0042493,GO:0042802,GO:0043279,GO:0050783,GO:0050805,GO:0051384,GO:0051593,GO:0072562" amyloid-beta binding|catalytic activity|acetylcholinesterase activity|cholinesterase activity|protein binding|extracellular region|nuclear envelope lumen|endoplasmic reticulum lumen|learning|negative regulation of cell population proliferation|neuroblast differentiation|membrane|choline metabolic process|enzyme binding|choline binding|response to drug|identical protein binding|response to alkaloid|cocaine metabolic process|negative regulation of synaptic transmission|response to glucocorticoid|response to folic acid|blood microparticle BCKDHA 603.0097846 574.4650781 631.554491 1.099378387 0.136688023 0.729095179 1 16.70185397 19.15260301 593 branched chain keto acid dehydrogenase E1 subunit alpha "GO:0003826,GO:0003863,GO:0005515,GO:0005739,GO:0005759,GO:0005947,GO:0009083,GO:0016831,GO:0046872,GO:0055114" alpha-ketoacid dehydrogenase activity|3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|protein binding|mitochondrion|mitochondrial matrix|mitochondrial alpha-ketoglutarate dehydrogenase complex|branched-chain amino acid catabolic process|carboxy-lyase activity|metal ion binding|oxidation-reduction process "hsa00280,hsa00640" "Valine, leucine and isoleucine degradation|Propanoate metabolism" BCKDHB 216.501588 218.2155332 214.7876428 0.984291263 -0.022842806 0.975062516 1 1.723619298 1.769623626 594 branched chain keto acid dehydrogenase E1 subunit beta "GO:0003826,GO:0003863,GO:0005515,GO:0005730,GO:0005739,GO:0005759,GO:0005947,GO:0007584,GO:0009083,GO:0055114" alpha-ketoacid dehydrogenase activity|3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|protein binding|nucleolus|mitochondrion|mitochondrial matrix|mitochondrial alpha-ketoglutarate dehydrogenase complex|response to nutrient|branched-chain amino acid catabolic process|oxidation-reduction process "hsa00280,hsa00640" "Valine, leucine and isoleucine degradation|Propanoate metabolism" BCKDK 1517.292609 1649.303449 1385.28177 0.839919283 -0.251677405 0.447429002 1 37.45802748 32.81696286 10295 branched chain keto acid dehydrogenase kinase "GO:0004674,GO:0004740,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005947,GO:0006468,GO:0009063,GO:0009083,GO:0010906,GO:0016301,GO:0016310,GO:0047323" protein serine/threonine kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|mitochondrial alpha-ketoglutarate dehydrogenase complex|protein phosphorylation|cellular amino acid catabolic process|branched-chain amino acid catabolic process|regulation of glucose metabolic process|kinase activity|phosphorylation|[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity BCL10 776.5605742 820.0844224 733.0367259 0.893855201 -0.161886953 0.66317034 1 10.53370097 9.821189398 8915 BCL10 immune signaling adaptor "GO:0001772,GO:0001783,GO:0001843,GO:0002020,GO:0002096,GO:0002223,GO:0002224,GO:0002250,GO:0002906,GO:0003713,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005829,GO:0005881,GO:0006968,GO:0007249,GO:0008022,GO:0008134,GO:0008219,GO:0009620,GO:0016064,GO:0016567,GO:0019209,GO:0019899,GO:0019900,GO:0019901,GO:0031398,GO:0031625,GO:0031663,GO:0032094,GO:0032449,GO:0032755,GO:0032757,GO:0032761,GO:0032765,GO:0032991,GO:0033674,GO:0038095,GO:0042327,GO:0042802,GO:0043065,GO:0043123,GO:0043280,GO:0043422,GO:0043621,GO:0044877,GO:0045087,GO:0045121,GO:0045893,GO:0048471,GO:0050700,GO:0050852,GO:0050856,GO:0050870,GO:0051059,GO:0051092,GO:0070231,GO:0071222,GO:0071260,GO:2001238" "immunological synapse|B cell apoptotic process|neural tube closure|protease binding|polkadots|stimulatory C-type lectin receptor signaling pathway|toll-like receptor signaling pathway|adaptive immune response|negative regulation of mature B cell apoptotic process|transcription coactivator activity|protein binding|nucleus|cytoplasm|lysosome|cytosol|cytoplasmic microtubule|cellular defense response|I-kappaB kinase/NF-kappaB signaling|protein C-terminus binding|transcription factor binding|cell death|response to fungus|immunoglobulin mediated immune response|protein ubiquitination|kinase activator activity|enzyme binding|kinase binding|protein kinase binding|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|response to food|CBM complex|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lymphotoxin A production|positive regulation of mast cell cytokine production|protein-containing complex|positive regulation of kinase activity|Fc-epsilon receptor signaling pathway|positive regulation of phosphorylation|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein kinase B binding|protein self-association|protein-containing complex binding|innate immune response|membrane raft|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm|CARD domain binding|T cell receptor signaling pathway|regulation of T cell receptor signaling pathway|positive regulation of T cell activation|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|T cell apoptotic process|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|positive regulation of extrinsic apoptotic signaling pathway" "hsa04064,hsa04625,hsa04660,hsa04662,hsa05131,hsa05152" NF-kappa B signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Shigellosis|Tuberculosis BCL2 209.7235033 226.3351809 193.1118256 0.853211705 -0.229024337 0.671126543 1 1.129812582 1.005493208 596 BCL2 apoptosis regulator "GO:0000209,GO:0001503,GO:0001541,GO:0001656,GO:0001658,GO:0001662,GO:0001782,GO:0001836,GO:0001952,GO:0002020,GO:0002320,GO:0002326,GO:0002931,GO:0003014,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0005829,GO:0006470,GO:0006582,GO:0006808,GO:0006915,GO:0006959,GO:0006974,GO:0007015,GO:0007409,GO:0007565,GO:0007569,GO:0008284,GO:0008584,GO:0008625,GO:0008630,GO:0008631,GO:0009314,GO:0009636,GO:0009791,GO:0010039,GO:0010224,GO:0010332,GO:0010468,GO:0010507,GO:0010523,GO:0010559,GO:0014031,GO:0014042,GO:0014911,GO:0015267,GO:0016020,GO:0016248,GO:0018105,GO:0018107,GO:0019221,GO:0021747,GO:0022612,GO:0022898,GO:0030279,GO:0030307,GO:0030308,GO:0030318,GO:0030336,GO:0030890,GO:0031069,GO:0031103,GO:0031625,GO:0031647,GO:0031965,GO:0032469,GO:0032835,GO:0032848,GO:0032991,GO:0033033,GO:0033077,GO:0033138,GO:0033689,GO:0034097,GO:0035094,GO:0035265,GO:0040018,GO:0042100,GO:0042149,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043029,GO:0043066,GO:0043085,GO:0043209,GO:0043375,GO:0043524,GO:0043565,GO:0043583,GO:0045069,GO:0045636,GO:0046671,GO:0046902,GO:0046930,GO:0046982,GO:0048041,GO:0048536,GO:0048538,GO:0048546,GO:0048599,GO:0048743,GO:0048753,GO:0048873,GO:0050853,GO:0051384,GO:0051402,GO:0051434,GO:0051607,GO:0051721,GO:0051881,GO:0051902,GO:0051924,GO:0055085,GO:0070059,GO:0070491,GO:0071456,GO:0072593,GO:0097192,GO:0098609,GO:1900740,GO:1902166,GO:2000134,GO:2000378,GO:2000811,GO:2001234,GO:2001240,GO:2001243,GO:2001244" "protein polyubiquitination|ossification|ovarian follicle development|metanephros development|branching involved in ureteric bud morphogenesis|behavioral fear response|B cell homeostasis|release of cytochrome c from mitochondria|regulation of cell-matrix adhesion|protease binding|lymphoid progenitor cell differentiation|B cell lineage commitment|response to ischemia|renal system process|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein dephosphorylation|melanin metabolic process|regulation of nitrogen utilization|apoptotic process|humoral immune response|cellular response to DNA damage stimulus|actin filament organization|axonogenesis|female pregnancy|cell aging|positive regulation of cell population proliferation|male gonad development|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|intrinsic apoptotic signaling pathway in response to oxidative stress|response to radiation|response to toxic substance|post-embryonic development|response to iron ion|response to UV-B|response to gamma radiation|regulation of gene expression|negative regulation of autophagy|negative regulation of calcium ion transport into cytosol|regulation of glycoprotein biosynthetic process|mesenchymal cell development|positive regulation of neuron maturation|positive regulation of smooth muscle cell migration|channel activity|membrane|channel inhibitor activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cytokine-mediated signaling pathway|cochlear nucleus development|gland morphogenesis|regulation of transmembrane transporter activity|negative regulation of ossification|positive regulation of cell growth|negative regulation of cell growth|melanocyte differentiation|negative regulation of cell migration|positive regulation of B cell proliferation|hair follicle morphogenesis|axon regeneration|ubiquitin protein ligase binding|regulation of protein stability|nuclear membrane|endoplasmic reticulum calcium ion homeostasis|glomerulus development|negative regulation of cellular pH reduction|protein-containing complex|negative regulation of myeloid cell apoptotic process|T cell differentiation in thymus|positive regulation of peptidyl-serine phosphorylation|negative regulation of osteoblast proliferation|response to cytokine|response to nicotine|organ growth|positive regulation of multicellular organism growth|B cell proliferation|cellular response to glucose starvation|response to drug|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|T cell homeostasis|negative regulation of apoptotic process|positive regulation of catalytic activity|myelin sheath|CD8-positive, alpha-beta T cell lineage commitment|negative regulation of neuron apoptotic process|sequence-specific DNA binding|ear development|regulation of viral genome replication|positive regulation of melanocyte differentiation|negative regulation of retinal cell programmed cell death|regulation of mitochondrial membrane permeability|pore complex|protein heterodimerization activity|focal adhesion assembly|spleen development|thymus development|digestive tract morphogenesis|oocyte development|positive regulation of skeletal muscle fiber development|pigment granule organization|homeostasis of number of cells within a tissue|B cell receptor signaling pathway|response to glucocorticoid|neuron apoptotic process|BH3 domain binding|defense response to virus|protein phosphatase 2A binding|regulation of mitochondrial membrane potential|negative regulation of mitochondrial depolarization|regulation of calcium ion transport|transmembrane transport|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|repressing transcription factor binding|cellular response to hypoxia|reactive oxygen species metabolic process|extrinsic apoptotic signaling pathway in absence of ligand|cell-cell adhesion|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of reactive oxygen species metabolic process|negative regulation of anoikis|negative regulation of apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway" "hsa01521,hsa01522,hsa01524,hsa04064,hsa04066,hsa04071,hsa04115,hsa04140,hsa04141,hsa04151,hsa04210,hsa04215,hsa04217,hsa04261,hsa04340,hsa04510,hsa04621,hsa04630,hsa04722,hsa04725,hsa04915,hsa04928,hsa04933,hsa05014,hsa05022,hsa05131,hsa05132,hsa05145,hsa05152,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05200,hsa05206,hsa05210,hsa05215,hsa05222,hsa05226,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|NF-kappa B signaling pathway|HIF-1 signaling pathway|Sphingolipid signaling pathway|p53 signaling pathway|Autophagy - animal|Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Adrenergic signaling in cardiomyocytes|Hedgehog signaling pathway|Focal adhesion|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Estrogen signaling pathway|Parathyroid hormone synthesis, secretion and action|AGE-RAGE signaling pathway in diabetic complications|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Salmonella infection|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer|Prostate cancer|Small cell lung cancer|Gastric cancer|Fluid shear stress and atherosclerosis" BCL2A1 16.13537506 25.37389921 6.896850916 0.271808872 -1.879335549 0.123622864 1 1.53719914 0.435822543 597 BCL2 related protein A1 "GO:0005515,GO:0005741,GO:0007568,GO:0008630,GO:0021987,GO:0042803,GO:0043066,GO:0044877,GO:0046982,GO:0051400,GO:0097192" protein binding|mitochondrial outer membrane|aging|intrinsic apoptotic signaling pathway in response to DNA damage|cerebral cortex development|protein homodimerization activity|negative regulation of apoptotic process|protein-containing complex binding|protein heterodimerization activity|BH domain binding|extrinsic apoptotic signaling pathway in absence of ligand "hsa04064,hsa04210,hsa05202,hsa05221" NF-kappa B signaling pathway|Apoptosis|Transcriptional misregulation in cancer|Acute myeloid leukemia BCL2L1 3865.403375 3281.352646 4449.454105 1.35598169 0.439337697 0.168202073 1 56.6038609 80.06004132 598 BCL2 like 1 "GO:0001836,GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005759,GO:0005813,GO:0005829,GO:0006897,GO:0007093,GO:0008630,GO:0008637,GO:0016021,GO:0019050,GO:0019221,GO:0019901,GO:0030672,GO:0031965,GO:0032465,GO:0034097,GO:0042802,GO:0042803,GO:0043066,GO:0046902,GO:0046982,GO:0051434,GO:0051607,GO:0051881,GO:0090201,GO:0097136,GO:0097192,GO:1900118,GO:1902042,GO:1902230,GO:1902236,GO:1903077,GO:2001240,GO:2001243,GO:2001244" release of cytochrome c from mitochondria|protein binding|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial matrix|centrosome|cytosol|endocytosis|mitotic cell cycle checkpoint|intrinsic apoptotic signaling pathway in response to DNA damage|apoptotic mitochondrial changes|integral component of membrane|suppression by virus of host apoptotic process|cytokine-mediated signaling pathway|protein kinase binding|synaptic vesicle membrane|nuclear membrane|regulation of cytokinesis|response to cytokine|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|regulation of mitochondrial membrane permeability|protein heterodimerization activity|BH3 domain binding|defense response to virus|regulation of mitochondrial membrane potential|negative regulation of release of cytochrome c from mitochondria|Bcl-2 family protein complex|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of execution phase of apoptosis|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of protein localization to plasma membrane|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway "hsa01521,hsa01524,hsa04014,hsa04064,hsa04115,hsa04137,hsa04140,hsa04151,hsa04210,hsa04215,hsa04621,hsa04630,hsa05012,hsa05014,hsa05022,hsa05131,hsa05145,hsa05162,hsa05166,hsa05168,hsa05170,hsa05200,hsa05202,hsa05212,hsa05220,hsa05222,hsa05225" EGFR tyrosine kinase inhibitor resistance|Platinum drug resistance|Ras signaling pathway|NF-kappa B signaling pathway|p53 signaling pathway|Mitophagy - animal|Autophagy - animal|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Parkinson disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Toxoplasmosis|Measles|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Pancreatic cancer|Chronic myeloid leukemia|Small cell lung cancer|Hepatocellular carcinoma BCL2L11 295.5899653 236.4847406 354.69519 1.499865019 0.58483267 0.218728082 1 1.55546985 2.433490771 10018 BCL2 like 11 "GO:0001701,GO:0001782,GO:0001783,GO:0001822,GO:0001844,GO:0002262,GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0007127,GO:0007160,GO:0007283,GO:0007420,GO:0008017,GO:0008584,GO:0008630,GO:0012505,GO:0019898,GO:0019901,GO:0030879,GO:0031334,GO:0034263,GO:0034976,GO:0035148,GO:0042475,GO:0042981,GO:0043029,GO:0043065,GO:0043280,GO:0043525,GO:0043583,GO:0045787,GO:0046620,GO:0048066,GO:0048070,GO:0048536,GO:0048538,GO:0048563,GO:0060139,GO:0070242,GO:0071385,GO:0071392,GO:0090200,GO:0097136,GO:0097192,GO:1902237,GO:1902263,GO:1903896,GO:1904646,GO:2000271,GO:2001244" in utero embryonic development|B cell homeostasis|B cell apoptotic process|kidney development|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|myeloid cell homeostasis|protein binding|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|meiosis I|cell-matrix adhesion|spermatogenesis|brain development|microtubule binding|male gonad development|intrinsic apoptotic signaling pathway in response to DNA damage|endomembrane system|extrinsic component of membrane|protein kinase binding|mammary gland development|positive regulation of protein-containing complex assembly|positive regulation of autophagy in response to ER overload|response to endoplasmic reticulum stress|tube formation|odontogenesis of dentin-containing tooth|regulation of apoptotic process|T cell homeostasis|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of neuron apoptotic process|ear development|positive regulation of cell cycle|regulation of organ growth|developmental pigmentation|regulation of developmental pigmentation|spleen development|thymus development|post-embryonic animal organ morphogenesis|positive regulation of apoptotic process by virus|thymocyte apoptotic process|cellular response to glucocorticoid stimulus|cellular response to estradiol stimulus|positive regulation of release of cytochrome c from mitochondria|Bcl-2 family protein complex|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|apoptotic process involved in embryonic digit morphogenesis|positive regulation of IRE1-mediated unfolded protein response|cellular response to amyloid-beta|positive regulation of fibroblast apoptotic process|positive regulation of intrinsic apoptotic signaling pathway "hsa01521,hsa04068,hsa04151,hsa04210,hsa04215,hsa04932,hsa05169,hsa05200,hsa05206,hsa05210" EGFR tyrosine kinase inhibitor resistance|FoxO signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|Non-alcoholic fatty liver disease|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer BCL2L12 474.2358237 426.2815067 522.1901408 1.224988963 0.292768751 0.480907449 1 9.981347427 12.75373175 83596 BCL2 like 12 "GO:0002039,GO:0005634,GO:0006915,GO:0016020,GO:0045944,GO:1902166,GO:1990001,GO:2000773,GO:2001236" p53 binding|nucleus|apoptotic process|membrane|positive regulation of transcription by RNA polymerase II|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|inhibition of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of cellular senescence|regulation of extrinsic apoptotic signaling pathway BCL2L13 1680.842543 1514.314305 1847.370781 1.219938803 0.286808779 0.380954454 1 13.10124314 16.67118542 23786 BCL2 like 13 "GO:0005515,GO:0005634,GO:0005739,GO:0006915,GO:0006919,GO:0008656,GO:0016021,GO:0031966,GO:0042981" protein binding|nucleus|mitochondrion|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cysteine-type endopeptidase activator activity involved in apoptotic process|integral component of membrane|mitochondrial membrane|regulation of apoptotic process "hsa04137,hsa05134" Mitophagy - animal|Legionellosis BCL2L15 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.030811552 0 440603 BCL2 like 15 "GO:0005515,GO:0005634,GO:0005829,GO:0006915,GO:0042981" protein binding|nucleus|cytosol|apoptotic process|regulation of apoptotic process BCL2L2 1213.791083 1040.329868 1387.252298 1.333473489 0.415189143 0.224161603 1 14.9430056 20.78443746 599 BCL2 like 2 "GO:0005515,GO:0005741,GO:0007283,GO:0008630,GO:0042802,GO:0042803,GO:0043066,GO:0046982,GO:0097136,GO:0097192,GO:0097718,GO:2001243" protein binding|mitochondrial outer membrane|spermatogenesis|intrinsic apoptotic signaling pathway in response to DNA damage|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|protein heterodimerization activity|Bcl-2 family protein complex|extrinsic apoptotic signaling pathway in absence of ligand|disordered domain specific binding|negative regulation of intrinsic apoptotic signaling pathway hsa05206 MicroRNAs in cancer BCL2L2-PABPN1 4.985705186 4.059823873 5.911586499 1.456118956 0.542128219 0.871693704 1 0.091384781 0.138799103 100529063 BCL2L2-PABPN1 readthrough "hsa03015,hsa05164" mRNA surveillance pathway|Influenza A BCL3 507.2515843 494.2835566 520.2196119 1.052472017 0.073781876 0.860563791 1 5.012758994 5.503048145 602 BCL3 transcription coactivator "GO:0000978,GO:0002268,GO:0002315,GO:0002455,GO:0002467,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0006974,GO:0007249,GO:0008134,GO:0009615,GO:0010225,GO:0019730,GO:0030198,GO:0030330,GO:0030496,GO:0030674,GO:0032717,GO:0032720,GO:0032729,GO:0032733,GO:0032991,GO:0032996,GO:0033257,GO:0042088,GO:0042742,GO:0042771,GO:0042832,GO:0042981,GO:0043066,GO:0043231,GO:0045064,GO:0045727,GO:0045892,GO:0045893,GO:0045944,GO:0046426,GO:0048471,GO:0048536,GO:0051101,GO:0051457,GO:1901222" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|follicular dendritic cell differentiation|marginal zone B cell differentiation|humoral immune response mediated by circulating immunoglobulin|germinal center formation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|cellular response to DNA damage stimulus|I-kappaB kinase/NF-kappaB signaling|transcription factor binding|response to virus|response to UV-C|antimicrobial humoral response|extracellular matrix organization|DNA damage response, signal transduction by p53 class mediator|midbody|protein-macromolecule adaptor activity|negative regulation of interleukin-8 production|negative regulation of tumor necrosis factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|protein-containing complex|Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|T-helper 1 type immune response|defense response to bacterium|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|defense response to protozoan|regulation of apoptotic process|negative regulation of apoptotic process|intracellular membrane-bounded organelle|T-helper 2 cell differentiation|positive regulation of translation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of receptor signaling pathway via JAK-STAT|perinuclear region of cytoplasm|spleen development|regulation of DNA binding|maintenance of protein location in nucleus|regulation of NIK/NF-kappaB signaling" "hsa04625,hsa04668" C-type lectin receptor signaling pathway|TNF signaling pathway other BCL6 381.4158493 378.5785762 384.2531225 1.014989084 0.021464212 0.967599758 1 1.946170254 2.060431267 604 BCL6 transcription repressor "GO:0000122,GO:0000902,GO:0000978,GO:0001161,GO:0001227,GO:0001817,GO:0001953,GO:0002467,GO:0002634,GO:0002682,GO:0002903,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005730,GO:0005794,GO:0006357,GO:0006954,GO:0006974,GO:0007266,GO:0007283,GO:0008104,GO:0008285,GO:0019221,GO:0030036,GO:0030183,GO:0030308,GO:0030890,GO:0031065,GO:0031490,GO:0032764,GO:0035024,GO:0042092,GO:0042127,GO:0042802,GO:0042981,GO:0043065,GO:0043087,GO:0043380,GO:0043565,GO:0045591,GO:0045595,GO:0045629,GO:0045666,GO:0045746,GO:0045892,GO:0046872,GO:0048294,GO:0048821,GO:0050727,GO:0050776,GO:0051272,GO:1903464,GO:1990837,GO:2000773" "negative regulation of transcription by RNA polymerase II|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|regulation of cytokine production|negative regulation of cell-matrix adhesion|germinal center formation|regulation of germinal center formation|regulation of immune system process|negative regulation of B cell apoptotic process|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|replication fork|nucleolus|Golgi apparatus|regulation of transcription by RNA polymerase II|inflammatory response|cellular response to DNA damage stimulus|Rho protein signal transduction|spermatogenesis|protein localization|negative regulation of cell population proliferation|cytokine-mediated signaling pathway|actin cytoskeleton organization|B cell differentiation|negative regulation of cell growth|positive regulation of B cell proliferation|positive regulation of histone deacetylation|chromatin DNA binding|negative regulation of mast cell cytokine production|negative regulation of Rho protein signal transduction|type 2 immune response|regulation of cell population proliferation|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|regulation of GTPase activity|regulation of memory T cell differentiation|sequence-specific DNA binding|positive regulation of regulatory T cell differentiation|regulation of cell differentiation|negative regulation of T-helper 2 cell differentiation|positive regulation of neuron differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|metal ion binding|negative regulation of isotype switching to IgE isotypes|erythrocyte development|regulation of inflammatory response|regulation of immune response|positive regulation of cellular component movement|negative regulation of mitotic cell cycle DNA replication|sequence-specific double-stranded DNA binding|negative regulation of cellular senescence" "hsa04068,hsa05202" FoxO signaling pathway|Transcriptional misregulation in cancer ZBTB BCL6B 10.49373413 10.14955968 10.83790858 1.067820568 0.094669242 1 1 0.145744086 0.162332379 255877 BCL6B transcription repressor "GO:0000122,GO:0000978,GO:0001227,GO:0001817,GO:0002682,GO:0005654,GO:0006357,GO:0042092,GO:0042127,GO:0045595,GO:0046872,GO:0050727,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|regulation of cytokine production|regulation of immune system process|nucleoplasm|regulation of transcription by RNA polymerase II|type 2 immune response|regulation of cell population proliferation|regulation of cell differentiation|metal ion binding|regulation of inflammatory response|sequence-specific double-stranded DNA binding" BCL7A 182.8271701 172.5425146 193.1118256 1.119213001 0.162484627 0.777152335 1 2.34784247 2.740928019 605 BAF chromatin remodeling complex subunit BCL7A "GO:0003674,GO:0005515,GO:0005575,GO:0045892" "molecular_function|protein binding|cellular_component|negative regulation of transcription, DNA-templated" BCL7B 1163.554722 1074.838371 1252.271073 1.165078497 0.22042716 0.521969763 1 30.49679085 37.06169332 9275 BAF chromatin remodeling complex subunit BCL7B "GO:0003779,GO:0005515,GO:0005575,GO:0006915,GO:0008150,GO:0016055,GO:0030154" actin binding|protein binding|cellular_component|apoptotic process|biological_process|Wnt signaling pathway|cell differentiation BCL7C 610.8918999 574.4650781 647.3187217 1.126819969 0.172257036 0.660396194 1 8.902885439 10.46408478 9274 BAF chromatin remodeling complex subunit BCL7C GO:0006915 apoptotic process BCL9 316.7083239 299.4120107 334.0046372 1.1155352 0.157736038 0.739056966 1 2.466920787 2.870479258 607 BCL9 transcription coactivator "GO:0003713,GO:0005515,GO:0005654,GO:0005801,GO:0008013,GO:0014908,GO:0017015,GO:0035019,GO:0035914,GO:0045944,GO:0060070,GO:1904837,GO:1990907" transcription coactivator activity|protein binding|nucleoplasm|cis-Golgi network|beta-catenin binding|myotube differentiation involved in skeletal muscle regeneration|regulation of transforming growth factor beta receptor signaling pathway|somatic stem cell population maintenance|skeletal muscle cell differentiation|positive regulation of transcription by RNA polymerase II|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex BCL9L 4683.338628 5650.259876 3716.417379 0.657742734 -0.604404688 0.059746787 1 25.29530008 17.35448877 283149 BCL9 like "GO:0003713,GO:0005634,GO:0005654,GO:0005730,GO:0008013,GO:0010718,GO:0022604,GO:0030512,GO:0035019,GO:0035914,GO:0045944,GO:0060070,GO:1904837,GO:1990907" transcription coactivator activity|nucleus|nucleoplasm|nucleolus|beta-catenin binding|positive regulation of epithelial to mesenchymal transition|regulation of cell morphogenesis|negative regulation of transforming growth factor beta receptor signaling pathway|somatic stem cell population maintenance|skeletal muscle cell differentiation|positive regulation of transcription by RNA polymerase II|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex BCLAF1 2849.403013 2897.69929 2801.106736 0.966665777 -0.048910928 0.878851395 1 19.16154153 19.32069381 9774 BCL2 associated transcription factor 1 "GO:0003677,GO:0003712,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006915,GO:0016592,GO:0016607,GO:0043065,GO:0043620,GO:0045892,GO:0045944,GO:1990830,GO:2000144,GO:2001022,GO:2001244" "DNA binding|transcription coregulator activity|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|apoptotic process|mediator complex|nuclear speck|positive regulation of apoptotic process|regulation of DNA-templated transcription in response to stress|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cellular response to leukemia inhibitory factor|positive regulation of DNA-templated transcription, initiation|positive regulation of response to DNA damage stimulus|positive regulation of intrinsic apoptotic signaling pathway" BCLAF3 308.8086412 331.8906017 285.7266808 0.860906212 -0.216072017 0.64830552 1 2.257768722 2.027455 256643 BCLAF1 and THRAP3 family member 3 "GO:0003677,GO:0003712,GO:0005739,GO:0016592,GO:0045944" DNA binding|transcription coregulator activity|mitochondrion|mediator complex|positive regulation of transcription by RNA polymerase II BCO2 14.50902068 15.22433953 13.79370183 0.906029572 -0.142369955 0.969242346 1 0.257448778 0.243303937 83875 beta-carotene oxygenase 2 "GO:0001523,GO:0003834,GO:0005739,GO:0005759,GO:0010436,GO:0016116,GO:0016119,GO:0016121,GO:0016122,GO:0016702,GO:0042573,GO:0042574,GO:0046872,GO:0051881,GO:0055114,GO:0102076,GO:2000377" "retinoid metabolic process|beta-carotene 15,15'-monooxygenase activity|mitochondrion|mitochondrial matrix|carotenoid dioxygenase activity|carotenoid metabolic process|carotene metabolic process|carotene catabolic process|xanthophyll metabolic process|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|retinoic acid metabolic process|retinal metabolic process|metal ion binding|regulation of mitochondrial membrane potential|oxidation-reduction process|beta,beta-carotene-9',10'-cleaving oxygenase activity|regulation of reactive oxygen species metabolic process" BCOR 1705.293036 1906.087309 1504.498764 0.789312618 -0.341331282 0.296291188 1 11.71276364 9.643270624 54880 BCL6 corepressor "GO:0000122,GO:0000415,GO:0000976,GO:0000977,GO:0001835,GO:0003714,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0007507,GO:0008134,GO:0030502,GO:0031072,GO:0035518,GO:0042476,GO:0042826,GO:0045892,GO:0051572,GO:0060021,GO:0065001,GO:0070171,GO:0140261" "negative regulation of transcription by RNA polymerase II|negative regulation of histone H3-K36 methylation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|blastocyst hatching|transcription corepressor activity|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|heart development|transcription factor binding|negative regulation of bone mineralization|heat shock protein binding|histone H2A monoubiquitination|odontogenesis|histone deacetylase binding|negative regulation of transcription, DNA-templated|negative regulation of histone H3-K4 methylation|roof of mouth development|specification of axis polarity|negative regulation of tooth mineralization|BCOR complex" other BCORL1 1670.476978 1580.286443 1760.667512 1.11414454 0.155936409 0.63469094 1 9.152193643 10.63610624 63035 BCL6 corepressor like 1 "GO:0005654,GO:0005886,GO:0006325" nucleoplasm|plasma membrane|chromatin organization BCR 1679.947591 1688.886731 1671.00845 0.989414162 -0.015353545 0.96454578 1 12.61037224 13.01433431 613 BCR activator of RhoGEF and GTPase "GO:0004674,GO:0005085,GO:0005096,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007165,GO:0007264,GO:0016020,GO:0016301,GO:0019899,GO:0030216,GO:0030424,GO:0032991,GO:0035023,GO:0043197,GO:0046777,GO:0048008,GO:0048041,GO:0050804,GO:0051056,GO:0070062,GO:0090630,GO:0098685,GO:0098978,GO:0099092,GO:0106310,GO:0106311" "protein serine/threonine kinase activity|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|ATP binding|cytosol|protein phosphorylation|signal transduction|small GTPase mediated signal transduction|membrane|kinase activity|enzyme binding|keratinocyte differentiation|axon|protein-containing complex|regulation of Rho protein signal transduction|dendritic spine|protein autophosphorylation|platelet-derived growth factor receptor signaling pathway|focal adhesion assembly|modulation of chemical synaptic transmission|regulation of small GTPase mediated signal transduction|extracellular exosome|activation of GTPase activity|Schaffer collateral - CA1 synapse|glutamatergic synapse|postsynaptic density, intracellular component|protein serine kinase activity|protein threonine kinase activity" "hsa05200,hsa05220" Pathways in cancer|Chronic myeloid leukemia BCS1L 296.1041242 338.9952934 253.2129551 0.746951241 -0.420914025 0.376289787 1 10.26849026 8.000456682 617 "BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone" "GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005750,GO:0007005,GO:0016021,GO:0016887,GO:0032979,GO:0032981,GO:0033617,GO:0034551" protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrion organization|integral component of membrane|ATPase activity|protein insertion into mitochondrial inner membrane from matrix|mitochondrial respiratory chain complex I assembly|mitochondrial cytochrome c oxidase assembly|mitochondrial respiratory chain complex III assembly BDH1 442.4144063 540.9715311 343.8572814 0.635629163 -0.653742778 0.121485572 1 2.513144342 1.666238546 622 3-hydroxybutyrate dehydrogenase 1 "GO:0003858,GO:0005739,GO:0005759,GO:0046951,GO:0046952,GO:0055114,GO:0099617" 3-hydroxybutyrate dehydrogenase activity|mitochondrion|mitochondrial matrix|ketone body biosynthetic process|ketone body catabolic process|oxidation-reduction process|matrix side of mitochondrial inner membrane "hsa00072,hsa00650" Synthesis and degradation of ketone bodies|Butanoate metabolism BDH2 333.6953514 315.6513062 351.7393967 1.114328976 0.156175213 0.737290829 1 4.95555645 5.759990683 56898 3-hydroxybutyrate dehydrogenase 2 "GO:0003858,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006635,GO:0016616,GO:0016628,GO:0019290,GO:0030855,GO:0042168,GO:0046951,GO:0051287,GO:0055072,GO:0070062" "3-hydroxybutyrate dehydrogenase activity|protein binding|cytoplasm|mitochondrion|cytosol|fatty acid beta-oxidation|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|siderophore biosynthetic process|epithelial cell differentiation|heme metabolic process|ketone body biosynthetic process|NAD binding|iron ion homeostasis|extracellular exosome" "hsa00072,hsa00650" Synthesis and degradation of ketone bodies|Butanoate metabolism BDKRB1 40.82364698 62.92727004 18.72002391 0.297486668 -1.749103078 0.057190285 1 2.449688112 0.76014113 623 bradykinin receptor B1 "GO:0001933,GO:0002687,GO:0004930,GO:0004947,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007204,GO:0007205,GO:0009612,GO:0016477,GO:0019233,GO:0030308,GO:0032496,GO:0042277,GO:0043005,GO:0045776,GO:0051281" negative regulation of protein phosphorylation|positive regulation of leukocyte migration|G protein-coupled receptor activity|bradykinin receptor activity|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G protein-coupled receptor signaling pathway|response to mechanical stimulus|cell migration|sensory perception of pain|negative regulation of cell growth|response to lipopolysaccharide|peptide binding|neuron projection|negative regulation of blood pressure|positive regulation of release of sequestered calcium ion into cytosol "hsa04020,hsa04080,hsa04610,hsa04750,hsa04810,hsa05200" Calcium signaling pathway|Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Pathways in cancer BDKRB2 3839.042489 5823.817347 1854.267632 0.318393851 -1.651115621 4.27E-07 0.000208098 73.81276362 24.51388065 624 bradykinin receptor B2 "GO:0002020,GO:0004435,GO:0004930,GO:0004947,GO:0005515,GO:0005768,GO:0005794,GO:0005886,GO:0005887,GO:0006939,GO:0006954,GO:0007166,GO:0007169,GO:0007186,GO:0007204,GO:0008015,GO:0009651,GO:0019229,GO:0031702,GO:0033137,GO:0042310,GO:0042311,GO:0043114,GO:0043231,GO:0046982,GO:0050482,GO:1902239" protease binding|phosphatidylinositol phospholipase C activity|G protein-coupled receptor activity|bradykinin receptor activity|protein binding|endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|smooth muscle contraction|inflammatory response|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|blood circulation|response to salt stress|regulation of vasoconstriction|type 1 angiotensin receptor binding|negative regulation of peptidyl-serine phosphorylation|vasoconstriction|vasodilation|regulation of vascular permeability|intracellular membrane-bounded organelle|protein heterodimerization activity|arachidonic acid secretion|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator "hsa04020,hsa04022,hsa04071,hsa04080,hsa04610,hsa04750,hsa04810,hsa04961,hsa05142,hsa05200" Calcium signaling pathway|cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Endocrine and other factor-regulated calcium reabsorption|Chagas disease|Pathways in cancer BDNF 234.666875 247.6492563 221.6844937 0.895155096 -0.159790428 0.7608416 1 1.487142658 1.38856703 627 brain derived neurotrophic factor "GO:0005163,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005739,GO:0007169,GO:0007202,GO:0007399,GO:0007411,GO:0007416,GO:0007422,GO:0007613,GO:0008021,GO:0008083,GO:0010832,GO:0010976,GO:0016607,GO:0021675,GO:0030424,GO:0030425,GO:0031547,GO:0031550,GO:0033138,GO:0038180,GO:0043524,GO:0045664,GO:0048011,GO:0048471,GO:0048668,GO:0048672,GO:0048812,GO:0050804,GO:0051965,GO:1900122,GO:1903997,GO:2000008,GO:2001234" nerve growth factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|mitochondrion|transmembrane receptor protein tyrosine kinase signaling pathway|activation of phospholipase C activity|nervous system development|axon guidance|synapse assembly|peripheral nervous system development|memory|synaptic vesicle|growth factor activity|negative regulation of myotube differentiation|positive regulation of neuron projection development|nuclear speck|nerve development|axon|dendrite|brain-derived neurotrophic factor receptor signaling pathway|positive regulation of brain-derived neurotrophic factor receptor signaling pathway|positive regulation of peptidyl-serine phosphorylation|nerve growth factor signaling pathway|negative regulation of neuron apoptotic process|regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|perinuclear region of cytoplasm|collateral sprouting|positive regulation of collateral sprouting|neuron projection morphogenesis|modulation of chemical synaptic transmission|positive regulation of synapse assembly|positive regulation of receptor binding|positive regulation of non-membrane spanning protein tyrosine kinase activity|regulation of protein localization to cell surface|negative regulation of apoptotic signaling pathway "hsa04010,hsa04014,hsa04024,hsa04151,hsa04722,hsa05016,hsa05022,hsa05030,hsa05034" MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|Neurotrophin signaling pathway|Huntington disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction|Alcoholism BDP1 2020.744913 2052.240968 1989.248857 0.969305695 -0.044976368 0.890341504 1 7.619585453 7.703853898 55814 "B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB" "GO:0000126,GO:0001156,GO:0005654,GO:0070898" transcription factor TFIIIB complex|TFIIIC-class transcription factor complex binding|nucleoplasm|RNA polymerase III preinitiation complex assembly other BEAN1 6.522984915 8.119647747 4.926322083 0.606716232 -0.720906186 0.726457076 1 0.049737725 0.031476575 146227 brain expressed associated with NEDD4 1 GO:0016021 integral component of membrane hsa05017 Spinocerebellar ataxia BECN1 1682.189549 1471.686154 1892.692944 1.286071041 0.362970338 0.267433452 1 32.99500306 44.26179902 8678 beclin 1 "GO:0000045,GO:0000407,GO:0000422,GO:0000423,GO:0001666,GO:0005515,GO:0005634,GO:0005739,GO:0005768,GO:0005776,GO:0005783,GO:0005789,GO:0005802,GO:0005829,GO:0006914,GO:0006915,GO:0006968,GO:0006995,GO:0007040,GO:0007080,GO:0007568,GO:0008285,GO:0010008,GO:0010040,GO:0010288,GO:0010613,GO:0014068,GO:0016032,GO:0016236,GO:0016579,GO:0019898,GO:0019901,GO:0030425,GO:0031625,GO:0031966,GO:0032465,GO:0032801,GO:0033197,GO:0034198,GO:0034271,GO:0034272,GO:0035032,GO:0042149,GO:0042493,GO:0042802,GO:0043066,GO:0043548,GO:0043652,GO:0045022,GO:0045324,GO:0045335,GO:0048666,GO:0050435,GO:0050790,GO:0051020,GO:0051301,GO:0051607,GO:0060548,GO:0070301,GO:0071275,GO:0071280,GO:0071364,GO:0098780,GO:1902425,GO:1902902,GO:1905672,GO:2000378,GO:2000786,GO:2001244" "autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|mitophagy|response to hypoxia|protein binding|nucleus|mitochondrion|endosome|autophagosome|endoplasmic reticulum|endoplasmic reticulum membrane|trans-Golgi network|cytosol|autophagy|apoptotic process|cellular defense response|cellular response to nitrogen starvation|lysosome organization|mitotic metaphase plate congression|aging|negative regulation of cell population proliferation|endosome membrane|response to iron(II) ion|response to lead ion|positive regulation of cardiac muscle hypertrophy|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|macroautophagy|protein deubiquitination|extrinsic component of membrane|protein kinase binding|dendrite|ubiquitin protein ligase binding|mitochondrial membrane|regulation of cytokinesis|receptor catabolic process|response to vitamin E|cellular response to amino acid starvation|phosphatidylinositol 3-kinase complex, class III, type I|phosphatidylinositol 3-kinase complex, class III, type II|phosphatidylinositol 3-kinase complex, class III|cellular response to glucose starvation|response to drug|identical protein binding|negative regulation of apoptotic process|phosphatidylinositol 3-kinase binding|engulfment of apoptotic cell|early endosome to late endosome transport|late endosome to vacuole transport|phagocytic vesicle|neuron development|amyloid-beta metabolic process|regulation of catalytic activity|GTPase binding|cell division|defense response to virus|negative regulation of cell death|cellular response to hydrogen peroxide|cellular response to aluminum ion|cellular response to copper ion|cellular response to epidermal growth factor stimulus|response to mitochondrial depolarisation|positive regulation of attachment of mitotic spindle microtubules to kinetochore|negative regulation of autophagosome assembly|negative regulation of lysosome organization|negative regulation of reactive oxygen species metabolic process|positive regulation of autophagosome assembly|positive regulation of intrinsic apoptotic signaling pathway" "hsa04136,hsa04137,hsa04140,hsa04215,hsa04371,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131,hsa05167" Autophagy - other|Mitophagy - animal|Autophagy - animal|Apoptosis - multiple species|Apelin signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection BEND3 152.4769683 185.7369422 119.2169944 0.641859358 -0.639670882 0.278391934 1 1.432671472 0.959185091 57673 BEN domain containing 3 "GO:0000122,GO:0000182,GO:0000183,GO:0000792,GO:0005515,GO:0005654,GO:0005730,GO:0006306,GO:0034773,GO:0036124,GO:0043967,GO:0051260,GO:0080182,GO:0098532,GO:1903580" negative regulation of transcription by RNA polymerase II|rDNA binding|rDNA heterochromatin assembly|heterochromatin|protein binding|nucleoplasm|nucleolus|DNA methylation|histone H4-K20 trimethylation|histone H3-K9 trimethylation|histone H4 acetylation|protein homooligomerization|histone H3-K4 trimethylation|histone H3-K27 trimethylation|positive regulation of ATP metabolic process BEND4 150.8681813 143.1087915 158.6275711 1.108440434 0.148531244 0.810807476 1 0.839758479 0.970918301 389206 BEN domain containing 4 BEND7 165.3799236 124.8395841 205.9202631 1.649478926 0.722010345 0.208851887 1 1.246586066 2.144790953 222389 BEN domain containing 7 "GO:0005515,GO:0070062" protein binding|extracellular exosome BEST1 15.00165289 15.22433953 14.77896625 0.970745971 -0.042834281 1 1 0.14592337 0.147756426 7439 bestrophin 1 "GO:0005254,GO:0005829,GO:0005886,GO:0006821,GO:0007601,GO:0009925,GO:0016020,GO:0016021,GO:0016323,GO:0030321,GO:0034220,GO:0034707,GO:0042802,GO:0050908,GO:0051924,GO:1902476" chloride channel activity|cytosol|plasma membrane|chloride transport|visual perception|basal plasma membrane|membrane|integral component of membrane|basolateral plasma membrane|transepithelial chloride transport|ion transmembrane transport|chloride channel complex|identical protein binding|detection of light stimulus involved in visual perception|regulation of calcium ion transport|chloride transmembrane transport BEST3 4.52276453 6.08973581 2.95579325 0.485372985 -1.042834281 0.660953233 1 0.048608926 0.02460977 144453 bestrophin 3 "GO:0003674,GO:0005254,GO:0005886,GO:0008150,GO:0034707,GO:0043271,GO:1902476" molecular_function|chloride channel activity|plasma membrane|biological_process|chloride channel complex|negative regulation of ion transport|chloride transmembrane transport BEST4 26.42126833 21.31407534 31.52846133 1.479231955 0.564848296 0.598127945 1 0.377309586 0.582170304 266675 bestrophin 4 "GO:0003674,GO:0005254,GO:0005886,GO:0008150,GO:0034707,GO:1902476" molecular_function|chloride channel activity|plasma membrane|biological_process|chloride channel complex|chloride transmembrane transport BET1 886.6969048 872.8621328 900.5316767 1.031699787 0.045023224 0.903552791 1 29.84968788 32.12247983 10282 Bet1 golgi vesicular membrane trafficking protein "GO:0000138,GO:0000139,GO:0005484,GO:0005515,GO:0005789,GO:0006888,GO:0015031,GO:0016020,GO:0030133,GO:0030173,GO:0031201,GO:0033116,GO:0048208,GO:0048280" Golgi trans cisterna|Golgi membrane|SNAP receptor activity|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|membrane|transport vesicle|integral component of Golgi membrane|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating|vesicle fusion with Golgi apparatus hsa04130 SNARE interactions in vesicular transport BET1L 1468.956753 1443.267387 1494.64612 1.035598901 0.050465339 0.881208104 1 24.92205987 26.92101597 51272 Bet1 golgi vesicular membrane trafficking protein like "GO:0000138,GO:0000139,GO:0005484,GO:0005768,GO:0005794,GO:0005829,GO:0006888,GO:0015031,GO:0016020,GO:0030173,GO:0031201,GO:0042147,GO:0061025,GO:2000156" "Golgi trans cisterna|Golgi membrane|SNAP receptor activity|endosome|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|membrane|integral component of Golgi membrane|SNARE complex|retrograde transport, endosome to Golgi|membrane fusion|regulation of retrograde vesicle-mediated transport, Golgi to ER" hsa04130 SNARE interactions in vesicular transport BEX2 4.463381426 2.029911937 6.896850916 3.397610897 1.764520641 0.414871268 1 0.091792749 0.325310398 84707 brain expressed X-linked 2 "GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0006915,GO:0007049,GO:0007165,GO:0042981,GO:0051726" signaling receptor binding|protein binding|nucleus|cytoplasm|apoptotic process|cell cycle|signal transduction|regulation of apoptotic process|regulation of cell cycle BEX3 3762.77208 4011.105987 3514.438174 0.876176841 -0.190706012 0.549359916 1 142.2607618 130.0148112 27018 brain expressed X-linked 3 "GO:0005102,GO:0005163,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0007165,GO:0007275,GO:0008656,GO:0042802,GO:0043154,GO:0043281,GO:0046872" signaling receptor binding|nerve growth factor receptor binding|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|multicellular organism development|cysteine-type endopeptidase activator activity involved in apoptotic process|identical protein binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|metal ion binding hsa04722 Neurotrophin signaling pathway BEX5 25.43600392 21.31407534 29.5579325 1.386779958 0.471738892 0.670485774 1 1.107161768 1.601528114 340542 brain expressed X-linked 5 "GO:0005102,GO:0005515,GO:0005737,GO:0007165" signaling receptor binding|protein binding|cytoplasm|signal transduction BFAR 1074.370725 1107.316961 1041.424488 0.940493575 -0.088510006 0.801363808 1 18.55166977 18.19930352 51283 bifunctional apoptosis regulator "GO:0000209,GO:0005515,GO:0005783,GO:0005887,GO:0006511,GO:0006915,GO:0016020,GO:0030176,GO:0030674,GO:0043066,GO:0043161,GO:0046872,GO:0051865,GO:0061630,GO:0070534,GO:0070936,GO:0089720,GO:1903895" protein polyubiquitination|protein binding|endoplasmic reticulum|integral component of plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|membrane|integral component of endoplasmic reticulum membrane|protein-macromolecule adaptor activity|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|caspase binding|negative regulation of IRE1-mediated unfolded protein response BFSP1 10.06048503 14.20938356 5.911586499 0.416033987 -1.265226703 0.381088004 1 0.248843413 0.107986854 631 beaded filament structural protein 1 "GO:0005200,GO:0005212,GO:0005515,GO:0005737,GO:0005882,GO:0005886,GO:0005938,GO:0008150,GO:0045109,GO:0048469,GO:0070307" structural constituent of cytoskeleton|structural constituent of eye lens|protein binding|cytoplasm|intermediate filament|plasma membrane|cell cortex|biological_process|intermediate filament organization|cell maturation|lens fiber cell development BGN 42.70782276 23.34398727 62.07165824 2.658999832 1.410883686 0.116681418 1 0.503316561 1.395967992 633 biglycan "GO:0001974,GO:0005201,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0005796,GO:0008150,GO:0009986,GO:0019800,GO:0030021,GO:0030133,GO:0030198,GO:0030206,GO:0030207,GO:0030208,GO:0031012,GO:0042383,GO:0043202,GO:0050840,GO:0060348,GO:0061975,GO:0062023,GO:0070062" blood vessel remodeling|extracellular matrix structural constituent|protein binding|glycosaminoglycan binding|extracellular region|extracellular space|Golgi lumen|biological_process|cell surface|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix structural constituent conferring compression resistance|transport vesicle|extracellular matrix organization|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|extracellular matrix|sarcolemma|lysosomal lumen|extracellular matrix binding|bone development|articular cartilage development|collagen-containing extracellular matrix|extracellular exosome BHLHA15 14.58324956 20.29911937 8.867379749 0.436835687 -1.194837375 0.340422573 1 0.315168236 0.143607288 168620 basic helix-loop-helix family member a15 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006851,GO:0007030,GO:0007186,GO:0007267,GO:0010832,GO:0019722,GO:0030182,GO:0030968,GO:0042149,GO:0042593,GO:0042802,GO:0045944,GO:0046983,GO:0048312,GO:0048469,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|mitochondrial calcium ion transmembrane transport|Golgi organization|G protein-coupled receptor signaling pathway|cell-cell signaling|negative regulation of myotube differentiation|calcium-mediated signaling|neuron differentiation|endoplasmic reticulum unfolded protein response|cellular response to glucose starvation|glucose homeostasis|identical protein binding|positive regulation of transcription by RNA polymerase II|protein dimerization activity|intracellular distribution of mitochondria|cell maturation|sequence-specific double-stranded DNA binding" hsa04950 Maturity onset diabetes of the young BHLHB9 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.012285836 0.037320505 80823 basic helix-loop-helix family member b9 "GO:0005515,GO:0005654,GO:0005829,GO:0007611,GO:0042803,GO:0043524,GO:0050769,GO:0051965,GO:0061003,GO:0070062" protein binding|nucleoplasm|cytosol|learning or memory|protein homodimerization activity|negative regulation of neuron apoptotic process|positive regulation of neurogenesis|positive regulation of synapse assembly|positive regulation of dendritic spine morphogenesis|extracellular exosome BHLHE40 2528.680148 3502.613047 1554.747249 0.443882104 -1.17175155 0.00028327 0.037641595 55.97822479 25.91807174 8553 basic helix-loop-helix family member e40 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001102,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0006357,GO:0007623,GO:0009952,GO:0016604,GO:0019904,GO:0032922,GO:0042752,GO:0042803,GO:0043153,GO:0043425,GO:0043426,GO:0043433,GO:0045892,GO:0046982,GO:0050767,GO:0070888,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|circadian rhythm|anterior/posterior pattern specification|nuclear body|protein domain specific binding|circadian regulation of gene expression|regulation of circadian rhythm|protein homodimerization activity|entrainment of circadian clock by photoperiod|bHLH transcription factor binding|MRF binding|negative regulation of DNA-binding transcription factor activity|negative regulation of transcription, DNA-templated|protein heterodimerization activity|regulation of neurogenesis|E-box binding|sequence-specific double-stranded DNA binding" hsa04710 Circadian rhythm bHLH BHLHE41 1504.815976 1975.104314 1034.527637 0.523783797 -0.932956663 0.005154682 0.273986513 26.7251044 14.60116134 79365 basic helix-loop-helix family member e41 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001102,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0009952,GO:0010832,GO:0010944,GO:0032922,GO:0042803,GO:0042826,GO:0043425,GO:0043426,GO:0045892,GO:0046982,GO:0050767,GO:0070888,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|negative regulation of myotube differentiation|negative regulation of transcription by competitive promoter binding|circadian regulation of gene expression|protein homodimerization activity|histone deacetylase binding|bHLH transcription factor binding|MRF binding|negative regulation of transcription, DNA-templated|protein heterodimerization activity|regulation of neurogenesis|E-box binding|sequence-specific double-stranded DNA binding" hsa04710 Circadian rhythm BICC1 530.0408346 570.4052542 489.676415 0.858471081 -0.22015856 0.586478942 1 1.741560999 1.559481725 80114 BicC family RNA binding protein 1 "GO:0001822,GO:0003723,GO:0005737,GO:0007368,GO:0007507,GO:0090090" kidney development|RNA binding|cytoplasm|determination of left/right symmetry|heart development|negative regulation of canonical Wnt signaling pathway BICD1 535.0413856 575.4800341 494.6027371 0.859461159 -0.218495652 0.588458961 1 2.25205019 2.018925296 636 BICD cargo adaptor 1 "GO:0005200,GO:0005515,GO:0005794,GO:0005802,GO:0005813,GO:0005829,GO:0005856,GO:0005881,GO:0006396,GO:0008093,GO:0008298,GO:0009653,GO:0016020,GO:0016032,GO:0019901,GO:0031267,GO:0031410,GO:0031871,GO:0033365,GO:0034063,GO:0034452,GO:0045298,GO:0045505,GO:0048260,GO:0048471,GO:0070507,GO:0070840,GO:0072385,GO:0072393,GO:0099503,GO:1900275,GO:1900276,GO:1900737,GO:1904781" structural constituent of cytoskeleton|protein binding|Golgi apparatus|trans-Golgi network|centrosome|cytosol|cytoskeleton|cytoplasmic microtubule|RNA processing|cytoskeletal anchor activity|intracellular mRNA localization|anatomical structure morphogenesis|membrane|viral process|protein kinase binding|small GTPase binding|cytoplasmic vesicle|proteinase activated receptor binding|protein localization to organelle|stress granule assembly|dynactin binding|tubulin complex|dynein intermediate chain binding|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|regulation of microtubule cytoskeleton organization|dynein complex binding|minus-end-directed organelle transport along microtubule|microtubule anchoring at microtubule organizing center|secretory vesicle|negative regulation of phospholipase C activity|regulation of proteinase activated receptor activity|negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of protein localization to centrosome BICD2 1988.783202 2056.300792 1921.265612 0.934331018 -0.097994331 0.762171102 1 15.9315253 15.5265174 23299 BICD cargo adaptor 2 "GO:0005515,GO:0005635,GO:0005642,GO:0005643,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005886,GO:0006890,GO:0007018,GO:0008093,GO:0015031,GO:0031267,GO:0031410,GO:0033365,GO:0034067,GO:0034452,GO:0051028,GO:0051642,GO:0051959,GO:0070507,GO:0070840,GO:0072385,GO:0072393" "protein binding|nuclear envelope|annulate lamellae|nuclear pore|cytoplasm|Golgi apparatus|centrosome|cytosol|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|cytoskeletal anchor activity|protein transport|small GTPase binding|cytoplasmic vesicle|protein localization to organelle|protein localization to Golgi apparatus|dynactin binding|mRNA transport|centrosome localization|dynein light intermediate chain binding|regulation of microtubule cytoskeleton organization|dynein complex binding|minus-end-directed organelle transport along microtubule|microtubule anchoring at microtubule organizing center" BICDL1 6.419064483 1.014955968 11.823173 11.64895165 3.542128219 0.075977894 1 0.009691542 0.11775942 92558 BICD family like cargo adaptor 1 "GO:0005737,GO:0005813,GO:0031175,GO:0031267,GO:0034452,GO:0047496,GO:0055107" cytoplasm|centrosome|neuron projection development|small GTPase binding|dynactin binding|vesicle transport along microtubule|Golgi to secretory granule transport BICRA 322.4241937 319.71113 325.1372575 1.016971969 0.024279915 0.965453212 1 2.241761161 2.378013156 29998 BRD4 interacting chromatin remodeling complex associated protein "GO:0003713,GO:0005515,GO:0005634,GO:0016514,GO:0045893,GO:0140537" "transcription coactivator activity|protein binding|nucleus|SWI/SNF complex|positive regulation of transcription, DNA-templated|transcription regulator activator activity" BICRAL 264.6229218 308.5466144 220.6992293 0.715286505 -0.483406873 0.32668251 1 2.256577261 1.683628111 23506 BRD4 interacting chromatin remodeling complex associated protein like "GO:0003713,GO:0005515,GO:0016514,GO:0045893" "transcription coactivator activity|protein binding|SWI/SNF complex|positive regulation of transcription, DNA-templated" BID 562.1549622 711.4841338 412.8257905 0.5802319 -0.785298482 0.048517338 1 13.5364994 8.192640531 637 BH3 interacting domain death agonist "GO:0001836,GO:0005123,GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0006626,GO:0006919,GO:0008625,GO:0008637,GO:0010918,GO:0016020,GO:0031334,GO:0031625,GO:0032592,GO:0042127,GO:0042770,GO:0042775,GO:0042981,GO:0043065,GO:0043066,GO:0051402,GO:0065003,GO:0090150,GO:0090200,GO:0097284,GO:0097345,GO:1900740,GO:1901030,GO:1902230,GO:2000045,GO:2000271,GO:2001238,GO:2001244" release of cytochrome c from mitochondria|death receptor binding|protein binding|mitochondrion|mitochondrial outer membrane|cytosol|protein targeting to mitochondrion|activation of cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway via death domain receptors|apoptotic mitochondrial changes|positive regulation of mitochondrial membrane potential|membrane|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|integral component of mitochondrial membrane|regulation of cell population proliferation|signal transduction in response to DNA damage|mitochondrial ATP synthesis coupled electron transport|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|neuron apoptotic process|protein-containing complex assembly|establishment of protein localization to membrane|positive regulation of release of cytochrome c from mitochondria|hepatocyte apoptotic process|mitochondrial outer membrane permeabilization|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|regulation of G1/S transition of mitotic cell cycle|positive regulation of fibroblast apoptotic process|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway "hsa01524,hsa04071,hsa04115,hsa04210,hsa04215,hsa04217,hsa04650,hsa04932,hsa05010,hsa05014,hsa05022,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05416" Platinum drug resistance|Sphingolipid signaling pathway|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Natural killer cell mediated cytotoxicity|Non-alcoholic fatty liver disease|Alzheimer disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral myocarditis BIK 35.48164317 34.50850292 36.45478341 1.056400027 0.079156243 0.965636939 1 1.83778542 2.02506578 638 BCL2 interacting killer "GO:0005515,GO:0006915,GO:0008584,GO:0008637,GO:0012505,GO:0016021,GO:0031334,GO:0031966,GO:0042981,GO:0090200" protein binding|apoptotic process|male gonad development|apoptotic mitochondrial changes|endomembrane system|integral component of membrane|positive regulation of protein-containing complex assembly|mitochondrial membrane|regulation of apoptotic process|positive regulation of release of cytochrome c from mitochondria hsa01522 Endocrine resistance BIN1 589.3915104 620.1380967 558.6449242 0.90083955 -0.150657926 0.703770912 1 8.404550945 7.897286412 274 bridging integrator 1 "GO:0002020,GO:0005515,GO:0005543,GO:0005634,GO:0005635,GO:0005737,GO:0005768,GO:0005829,GO:0005856,GO:0005886,GO:0006897,GO:0006997,GO:0007010,GO:0008021,GO:0008333,GO:0015629,GO:0016020,GO:0016032,GO:0019828,GO:0030018,GO:0030100,GO:0030276,GO:0030315,GO:0030424,GO:0030425,GO:0030838,GO:0031674,GO:0031982,GO:0033268,GO:0033292,GO:0042802,GO:0043065,GO:0043194,GO:0045664,GO:0048156,GO:0048711,GO:0051015,GO:0051087,GO:0051647,GO:0060987,GO:0060988,GO:0061024,GO:0070063,GO:0071156,GO:0086091,GO:1901380,GO:1902430,GO:1902960,GO:1903946,GO:1904878" protease binding|protein binding|phospholipid binding|nucleus|nuclear envelope|cytoplasm|endosome|cytosol|cytoskeleton|plasma membrane|endocytosis|nucleus organization|cytoskeleton organization|synaptic vesicle|endosome to lysosome transport|actin cytoskeleton|membrane|viral process|aspartic-type endopeptidase inhibitor activity|Z disc|regulation of endocytosis|clathrin binding|T-tubule|axon|dendrite|positive regulation of actin filament polymerization|I band|vesicle|node of Ranvier|T-tubule organization|identical protein binding|positive regulation of apoptotic process|axon initial segment|regulation of neuron differentiation|tau protein binding|positive regulation of astrocyte differentiation|actin filament binding|chaperone binding|nucleus localization|lipid tube|lipid tube assembly|membrane organization|RNA polymerase binding|regulation of cell cycle arrest|regulation of heart rate by cardiac conduction|negative regulation of potassium ion transmembrane transport|negative regulation of amyloid-beta formation|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of ventricular cardiac muscle cell action potential|negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel "hsa04144,hsa04666" Endocytosis|Fc gamma R-mediated phagocytosis BIN3 279.3182566 235.4697847 323.1667286 1.372433958 0.456736728 0.345908977 1 3.950219909 5.654948558 55909 bridging integrator 3 "GO:0000917,GO:0005515,GO:0005737,GO:0006897,GO:0007015,GO:0008093,GO:0008104,GO:0008289,GO:0009826,GO:0010591,GO:0014839,GO:0015629,GO:0048741,GO:0051666,GO:0061640,GO:0097320" division septum assembly|protein binding|cytoplasm|endocytosis|actin filament organization|cytoskeletal anchor activity|protein localization|lipid binding|unidimensional cell growth|regulation of lamellipodium assembly|myoblast migration involved in skeletal muscle regeneration|actin cytoskeleton|skeletal muscle fiber development|actin cortical patch localization|cytoskeleton-dependent cytokinesis|plasma membrane tubulation BIRC2 1245.922778 1148.930156 1342.9154 1.168839892 0.225077323 0.508685414 1 13.74657671 16.75967201 329 baculoviral IAP repeat containing 2 "GO:0000209,GO:0001666,GO:0001741,GO:0001890,GO:0002756,GO:0003713,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0007166,GO:0007249,GO:0008270,GO:0009898,GO:0010803,GO:0016579,GO:0016740,GO:0031398,GO:0033209,GO:0034121,GO:0035631,GO:0035666,GO:0038061,GO:0039535,GO:0042127,GO:0042802,GO:0042981,GO:0043027,GO:0043066,GO:0043123,GO:0043130,GO:0043161,GO:0044877,GO:0045088,GO:0045121,GO:0045471,GO:0045595,GO:0045893,GO:0047485,GO:0050727,GO:0051087,GO:0051591,GO:0051726,GO:0060544,GO:0060546,GO:0061630,GO:0070266,GO:0070424,GO:0098770,GO:1901222,GO:1902443,GO:1902523,GO:1902524,GO:1902527,GO:2000116,GO:2000377" "protein polyubiquitination|response to hypoxia|XY body|placenta development|MyD88-independent toll-like receptor signaling pathway|transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|cell surface receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|zinc ion binding|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|protein deubiquitination|transferase activity|positive regulation of protein ubiquitination|tumor necrosis factor-mediated signaling pathway|regulation of toll-like receptor signaling pathway|CD40 receptor complex|TRIF-dependent toll-like receptor signaling pathway|NIK/NF-kappaB signaling|regulation of RIG-I signaling pathway|regulation of cell population proliferation|identical protein binding|regulation of apoptotic process|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|regulation of innate immune response|membrane raft|response to ethanol|regulation of cell differentiation|positive regulation of transcription, DNA-templated|protein N-terminus binding|regulation of inflammatory response|chaperone binding|response to cAMP|regulation of cell cycle|regulation of necroptotic process|negative regulation of necroptotic process|ubiquitin protein ligase activity|necroptotic process|regulation of nucleotide-binding oligomerization domain containing signaling pathway|FBXO family protein binding|regulation of NIK/NF-kappaB signaling|negative regulation of ripoptosome assembly involved in necroptotic process|positive regulation of protein K63-linked ubiquitination|positive regulation of protein K48-linked ubiquitination|positive regulation of protein monoubiquitination|regulation of cysteine-type endopeptidase activity|regulation of reactive oxygen species metabolic process" "hsa01524,hsa04064,hsa04120,hsa04210,hsa04215,hsa04217,hsa04390,hsa04510,hsa04621,hsa04668,hsa05132,hsa05145,hsa05168,hsa05200,hsa05202,hsa05222" Platinum drug resistance|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Apoptosis|Apoptosis - multiple species|Necroptosis|Hippo signaling pathway|Focal adhesion|NOD-like receptor signaling pathway|TNF signaling pathway|Salmonella infection|Toxoplasmosis|Herpes simplex virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer BIRC3 171.8353606 229.3800489 114.2906723 0.498258994 -1.005032249 0.077153154 1 2.623597622 1.363541326 330 baculoviral IAP repeat containing 3 "GO:0002756,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0007166,GO:0007249,GO:0010803,GO:0016567,GO:0016579,GO:0016740,GO:0031398,GO:0033209,GO:0034121,GO:0035666,GO:0038061,GO:0039535,GO:0042981,GO:0043027,GO:0043066,GO:0043123,GO:0045088,GO:0046872,GO:0050727,GO:0051726,GO:0060544,GO:0060546,GO:0061630,GO:0070424,GO:2000116" MyD88-independent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|cell surface receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|regulation of tumor necrosis factor-mediated signaling pathway|protein ubiquitination|protein deubiquitination|transferase activity|positive regulation of protein ubiquitination|tumor necrosis factor-mediated signaling pathway|regulation of toll-like receptor signaling pathway|TRIF-dependent toll-like receptor signaling pathway|NIK/NF-kappaB signaling|regulation of RIG-I signaling pathway|regulation of apoptotic process|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of innate immune response|metal ion binding|regulation of inflammatory response|regulation of cell cycle|regulation of necroptotic process|negative regulation of necroptotic process|ubiquitin protein ligase activity|regulation of nucleotide-binding oligomerization domain containing signaling pathway|regulation of cysteine-type endopeptidase activity "hsa01524,hsa04064,hsa04120,hsa04210,hsa04215,hsa04217,hsa04390,hsa04510,hsa04621,hsa04668,hsa05132,hsa05145,hsa05168,hsa05200,hsa05202,hsa05222" Platinum drug resistance|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Apoptosis|Apoptosis - multiple species|Necroptosis|Hippo signaling pathway|Focal adhesion|NOD-like receptor signaling pathway|TNF signaling pathway|Salmonella infection|Toxoplasmosis|Herpes simplex virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer BIRC5 1394.977053 1201.707867 1588.246239 1.321657521 0.402348382 0.229431803 1 23.02772004 31.74576538 332 baculoviral IAP repeat containing 5 "GO:0000228,GO:0000775,GO:0000777,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005876,GO:0006468,GO:0006915,GO:0007059,GO:0007605,GO:0008017,GO:0008284,GO:0019221,GO:0019899,GO:0030496,GO:0031267,GO:0031503,GO:0032133,GO:0042802,GO:0042981,GO:0043027,GO:0043066,GO:0045892,GO:0046872,GO:0051087,GO:0051301,GO:0051726" "nuclear chromosome|chromosome, centromeric region|condensed chromosome kinetochore|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|spindle microtubule|protein phosphorylation|apoptotic process|chromosome segregation|sensory perception of sound|microtubule binding|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|enzyme binding|midbody|small GTPase binding|protein-containing complex localization|chromosome passenger complex|identical protein binding|regulation of apoptotic process|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of transcription, DNA-templated|metal ion binding|chaperone binding|cell division|regulation of cell cycle" "hsa01524,hsa04210,hsa04215,hsa04390,hsa05161,hsa05200,hsa05210" Platinum drug resistance|Apoptosis|Apoptosis - multiple species|Hippo signaling pathway|Hepatitis B|Pathways in cancer|Colorectal cancer BIRC6 3224.71824 3398.072582 3051.363898 0.897969018 -0.155262426 0.625765072 1 8.758735234 8.203868314 57448 baculoviral IAP repeat containing 6 "GO:0000922,GO:0004842,GO:0004869,GO:0005515,GO:0005634,GO:0005768,GO:0005802,GO:0005815,GO:0006468,GO:0006511,GO:0006915,GO:0007049,GO:0008284,GO:0010951,GO:0016020,GO:0016567,GO:0030496,GO:0032465,GO:0042127,GO:0043066,GO:0051301,GO:0060711,GO:0061631,GO:0090543,GO:2001237" spindle pole|ubiquitin-protein transferase activity|cysteine-type endopeptidase inhibitor activity|protein binding|nucleus|endosome|trans-Golgi network|microtubule organizing center|protein phosphorylation|ubiquitin-dependent protein catabolic process|apoptotic process|cell cycle|positive regulation of cell population proliferation|negative regulation of endopeptidase activity|membrane|protein ubiquitination|midbody|regulation of cytokinesis|regulation of cell population proliferation|negative regulation of apoptotic process|cell division|labyrinthine layer development|ubiquitin conjugating enzyme activity|Flemming body|negative regulation of extrinsic apoptotic signaling pathway "hsa04120,hsa04215" Ubiquitin mediated proteolysis|Apoptosis - multiple species BIVM 219.5019186 221.2604011 217.7434361 0.98410486 -0.023116047 0.974390361 1 2.941222771 3.019153722 54841 "basic, immunoglobulin-like variable motif containing" "GO:0005515,GO:0005615,GO:0005634,GO:0005737" protein binding|extracellular space|nucleus|cytoplasm BLCAP 1953.2397 1680.767084 2225.712317 1.324224123 0.405147317 0.209661018 1 24.14206563 33.34662232 10904 BLCAP apoptosis inducing factor "GO:0005515,GO:0007049,GO:0016021,GO:0030262" protein binding|cell cycle|integral component of membrane|apoptotic nuclear changes BLID 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.29340148 0.297087122 414899 "BH3-like motif containing, cell death inducer" "GO:0003674,GO:0005739,GO:0005829,GO:0006915,GO:0043280" molecular_function|mitochondrion|cytosol|apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process BLM 834.8208274 694.2298824 975.4117724 1.405027063 0.490597919 0.178288027 1 6.951422389 10.1876566 641 BLM RecQ like helicase "GO:0000079,GO:0000228,GO:0000400,GO:0000403,GO:0000405,GO:0000723,GO:0000724,GO:0000729,GO:0000733,GO:0000781,GO:0000800,GO:0002039,GO:0003677,GO:0003678,GO:0003697,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0006260,GO:0006268,GO:0006281,GO:0006310,GO:0006974,GO:0007095,GO:0008094,GO:0008270,GO:0009378,GO:0010165,GO:0016363,GO:0016605,GO:0016887,GO:0031297,GO:0032508,GO:0032991,GO:0036310,GO:0042802,GO:0042803,GO:0043138,GO:0044806,GO:0045893,GO:0045910,GO:0048478,GO:0051259,GO:0051260,GO:0051782,GO:0051880,GO:0061749,GO:0061820,GO:0061821,GO:0061849,GO:0071479,GO:0072711,GO:0072757,GO:0090329,GO:0090656,GO:1901796,GO:1905773" "regulation of cyclin-dependent protein serine/threonine kinase activity|nuclear chromosome|four-way junction DNA binding|Y-form DNA binding|bubble DNA binding|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|DNA strand renaturation|chromosome, telomeric region|lateral element|p53 binding|DNA binding|DNA helicase activity|single-stranded DNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|chromosome|nucleolus|cytoplasm|cytosol|DNA replication|DNA unwinding involved in DNA replication|DNA repair|DNA recombination|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|DNA-dependent ATPase activity|zinc ion binding|four-way junction helicase activity|response to X-ray|nuclear matrix|PML body|ATPase activity|replication fork processing|DNA duplex unwinding|protein-containing complex|annealing helicase activity|identical protein binding|protein homodimerization activity|3'-5' DNA helicase activity|G-quadruplex DNA unwinding|positive regulation of transcription, DNA-templated|negative regulation of DNA recombination|replication fork protection|protein complex oligomerization|protein homooligomerization|negative regulation of cell division|G-quadruplex DNA binding|forked DNA-dependent helicase activity|telomeric D-loop disassembly|telomeric D-loop binding|telomeric G-quadruplex DNA binding|cellular response to ionizing radiation|cellular response to hydroxyurea|cellular response to camptothecin|regulation of DNA-dependent DNA replication|t-circle formation|regulation of signal transduction by p53 class mediator|8-hydroxy-2'-deoxyguanosine DNA binding" "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway BLMH 1099.130504 1183.438659 1014.822349 0.857520025 -0.221757732 0.523286131 1 25.98049118 23.23847144 642 bleomycin hydrolase "GO:0000209,GO:0004177,GO:0004180,GO:0004197,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008234,GO:0009636,GO:0042493,GO:0042802,GO:0043418,GO:0070062" protein polyubiquitination|aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding|nucleus|cytoplasm|cytosol|proteolysis|cysteine-type peptidase activity|response to toxic substance|response to drug|identical protein binding|homocysteine catabolic process|extracellular exosome BLOC1S1 467.9206797 432.3712425 503.4701169 1.164439415 0.219635579 0.599381715 1 38.96455181 47.32629565 2647 biogenesis of lysosomal organelles complex 1 subunit 1 "GO:0005515,GO:0005615,GO:0005739,GO:0005758,GO:0005759,GO:0005765,GO:0005829,GO:0008089,GO:0009060,GO:0016197,GO:0018394,GO:0031083,GO:0031175,GO:0032418,GO:0032438,GO:0048490,GO:0060155,GO:0099078,GO:1904115" protein binding|extracellular space|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|lysosomal membrane|cytosol|anterograde axonal transport|aerobic respiration|endosomal transport|peptidyl-lysine acetylation|BLOC-1 complex|neuron projection development|lysosome localization|melanosome organization|anterograde synaptic vesicle transport|platelet dense granule organization|BORC complex|axon cytoplasm BLOC1S2 798.2930528 857.6377933 738.9483124 0.86160885 -0.214895027 0.559903229 1 14.46913013 13.00374676 282991 biogenesis of lysosomal organelles complex 1 subunit 2 "GO:0000930,GO:0005515,GO:0005739,GO:0005765,GO:0008089,GO:0008625,GO:0016197,GO:0031083,GO:0031175,GO:0032418,GO:0032438,GO:0043015,GO:0048490,GO:0060155,GO:0097345,GO:0099078,GO:1904115" gamma-tubulin complex|protein binding|mitochondrion|lysosomal membrane|anterograde axonal transport|extrinsic apoptotic signaling pathway via death domain receptors|endosomal transport|BLOC-1 complex|neuron projection development|lysosome localization|melanosome organization|gamma-tubulin binding|anterograde synaptic vesicle transport|platelet dense granule organization|mitochondrial outer membrane permeabilization|BORC complex|axon cytoplasm BLOC1S3 242.370841 235.4697847 249.2718974 1.058615218 0.082178298 0.878735151 1 4.656662985 5.141962092 388552 biogenesis of lysosomal organelles complex 1 subunit 3 "GO:0001654,GO:0003674,GO:0005515,GO:0005829,GO:0008089,GO:0008320,GO:0030133,GO:0030168,GO:0031083,GO:0031175,GO:0032402,GO:0032438,GO:0032816,GO:0033299,GO:0035646,GO:0042493,GO:0043473,GO:0048490,GO:0060155,GO:0071806,GO:1904115" eye development|molecular_function|protein binding|cytosol|anterograde axonal transport|protein transmembrane transporter activity|transport vesicle|platelet activation|BLOC-1 complex|neuron projection development|melanosome transport|melanosome organization|positive regulation of natural killer cell activation|secretion of lysosomal enzymes|endosome to melanosome transport|response to drug|pigmentation|anterograde synaptic vesicle transport|platelet dense granule organization|protein transmembrane transport|axon cytoplasm BLOC1S4 318.8367131 377.5636202 260.109806 0.688916495 -0.537598973 0.246876016 1 12.8251277 9.216037035 55330 biogenesis of lysosomal organelles complex 1 subunit 4 "GO:0005515,GO:0005737,GO:0005829,GO:0008089,GO:0031083,GO:0031175,GO:0032438,GO:0048490,GO:0050885,GO:0070527,GO:1904115" protein binding|cytoplasm|cytosol|anterograde axonal transport|BLOC-1 complex|neuron projection development|melanosome organization|anterograde synaptic vesicle transport|neuromuscular process controlling balance|platelet aggregation|axon cytoplasm BLOC1S5 286.9277048 284.1876711 289.6677385 1.019283269 0.027555047 0.962085111 1 5.211116216 5.540405912 63915 biogenesis of lysosomal organelles complex 1 subunit 5 "GO:0005515,GO:0008089,GO:0030133,GO:0031083,GO:0031175,GO:0032402,GO:0032438,GO:0035646,GO:0048490,GO:0050942,GO:1904115" protein binding|anterograde axonal transport|transport vesicle|BLOC-1 complex|neuron projection development|melanosome transport|melanosome organization|endosome to melanosome transport|anterograde synaptic vesicle transport|positive regulation of pigment cell differentiation|axon cytoplasm BLOC1S6 746.5302985 754.1122845 738.9483124 0.979891626 -0.029305896 0.941063973 1 9.493692981 9.703516724 26258 biogenesis of lysosomal organelles complex 1 subunit 6 "GO:0005515,GO:0005737,GO:0005829,GO:0008089,GO:0016081,GO:0019898,GO:0019905,GO:0030133,GO:0031083,GO:0031175,GO:0031201,GO:0032402,GO:0032438,GO:0035646,GO:0042802,GO:0042803,GO:0046907,GO:0048490,GO:0050942,GO:0051015,GO:0098793,GO:1904115" protein binding|cytoplasm|cytosol|anterograde axonal transport|synaptic vesicle docking|extrinsic component of membrane|syntaxin binding|transport vesicle|BLOC-1 complex|neuron projection development|SNARE complex|melanosome transport|melanosome organization|endosome to melanosome transport|identical protein binding|protein homodimerization activity|intracellular transport|anterograde synaptic vesicle transport|positive regulation of pigment cell differentiation|actin filament binding|presynapse|axon cytoplasm BLVRA 950.1601066 833.27885 1067.041363 1.280533357 0.356744835 0.315927795 1 30.18786418 40.32173519 644 biliverdin reductase A "GO:0004074,GO:0005515,GO:0005829,GO:0008270,GO:0042167,GO:0055114,GO:0070062,GO:0106276,GO:0106277" biliverdin reductase (NAD(P)+) activity|protein binding|cytosol|zinc ion binding|heme catabolic process|oxidation-reduction process|extracellular exosome|biliberdin reductase NAD+ activity|biliverdin reductase (NADP+) activity hsa00860 Porphyrin and chlorophyll metabolism BLVRB 497.693134 548.0762229 447.3100451 0.816145686 -0.293101391 0.474843174 1 34.74108535 29.5751531 645 biliverdin reductase B "GO:0004074,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0042167,GO:0042602,GO:0043231,GO:0055114,GO:0070062,GO:0106276,GO:0106277" biliverdin reductase (NAD(P)+) activity|protein binding|nucleoplasm|cytosol|plasma membrane|heme catabolic process|riboflavin reductase (NADPH) activity|intracellular membrane-bounded organelle|oxidation-reduction process|extracellular exosome|biliberdin reductase NAD+ activity|biliverdin reductase (NADP+) activity "hsa00740,hsa00860" Riboflavin metabolism|Porphyrin and chlorophyll metabolism BLZF1 446.3136482 504.4331163 388.1941801 0.769565216 -0.377884503 0.369758468 1 7.076941221 5.680766621 8548 basic leucine zipper nuclear factor 1 "GO:0000139,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0007030,GO:0019899,GO:0031625,GO:0043001" Golgi membrane|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|Golgi organization|enzyme binding|ubiquitin protein ligase binding|Golgi to plasma membrane protein transport BMERB1 398.4583006 263.8885518 533.0280494 2.019898346 1.01428269 0.02023168 0.616714654 6.091624524 12.83448864 89927 bMERB domain containing 1 "GO:0005515,GO:0007026,GO:0015630,GO:0021822" protein binding|negative regulation of microtubule depolymerization|microtubule cytoskeleton|negative regulation of cell motility involved in cerebral cortex radial glia guided migration BMF 1985.863289 2900.744158 1070.982421 0.369209542 -1.437488257 1.20E-05 0.00286122 29.6313954 11.4114531 90427 Bcl2 modifying factor "GO:0001669,GO:0001844,GO:0005515,GO:0005741,GO:0005829,GO:0005886,GO:0010507,GO:0016459,GO:0031334,GO:0034644,GO:0043065,GO:0043276,GO:0090200,GO:2001244" acrosomal vesicle|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|protein binding|mitochondrial outer membrane|cytosol|plasma membrane|negative regulation of autophagy|myosin complex|positive regulation of protein-containing complex assembly|cellular response to UV|positive regulation of apoptotic process|anoikis|positive regulation of release of cytochrome c from mitochondria|positive regulation of intrinsic apoptotic signaling pathway hsa05206 MicroRNAs in cancer BMI1 45.94568575 42.62815067 49.26322083 1.155649965 0.208704486 0.831776483 1 0.609877245 0.735164742 648 "BMI1 proto-oncogene, polycomb ring finger" "GO:0000122,GO:0000151,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006342,GO:0007379,GO:0008270,GO:0010468,GO:0016604,GO:0030097,GO:0031519,GO:0035102,GO:0036353,GO:0045814,GO:0048146,GO:0051443,GO:0070317,GO:0071535,GO:1990841" "negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|protein binding|nucleus|nucleoplasm|cytosol|chromatin silencing|segment specification|zinc ion binding|regulation of gene expression|nuclear body|hemopoiesis|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|negative regulation of gene expression, epigenetic|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein transferase activity|negative regulation of G0 to G1 transition|RING-like zinc finger domain binding|promoter-specific chromatin binding" "hsa04550,hsa05202,hsa05206" Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer|MicroRNAs in cancer chromosome_remodelling_factor BMP1 803.8104844 931.729579 675.8913898 0.725415834 -0.463119858 0.207143605 1 11.92238914 9.021240349 649 bone morphogenetic protein 1 "GO:0001501,GO:0001502,GO:0001503,GO:0004222,GO:0005125,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0006508,GO:0007165,GO:0007275,GO:0008083,GO:0008233,GO:0008237,GO:0008270,GO:0022617,GO:0030154,GO:0031982,GO:0034380,GO:0042802,GO:0061036" skeletal system development|cartilage condensation|ossification|metalloendopeptidase activity|cytokine activity|calcium ion binding|protein binding|extracellular region|extracellular space|Golgi apparatus|proteolysis|signal transduction|multicellular organism development|growth factor activity|peptidase activity|metallopeptidase activity|zinc ion binding|extracellular matrix disassembly|cell differentiation|vesicle|high-density lipoprotein particle assembly|identical protein binding|positive regulation of cartilage development BMP2 5.493183171 5.074779842 5.911586499 1.164895165 0.220200125 1 1 0.07250203 0.088095341 650 bone morphogenetic protein 2 "GO:0000122,GO:0000187,GO:0001501,GO:0001649,GO:0001658,GO:0001666,GO:0001701,GO:0001837,GO:0001934,GO:0001938,GO:0002062,GO:0003130,GO:0003176,GO:0003181,GO:0003203,GO:0003210,GO:0003272,GO:0003308,GO:0003331,GO:0004745,GO:0005102,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0006029,GO:0006355,GO:0006468,GO:0006954,GO:0007219,GO:0007267,GO:0007507,GO:0008083,GO:0008285,GO:0009617,GO:0009887,GO:0009986,GO:0010628,GO:0010629,GO:0010718,GO:0010862,GO:0010894,GO:0010922,GO:0019211,GO:0021537,GO:0021978,GO:0030177,GO:0030282,GO:0030335,GO:0030501,GO:0030509,GO:0031648,GO:0032092,GO:0032348,GO:0033690,GO:0035051,GO:0035054,GO:0035630,GO:0039706,GO:0042475,GO:0042482,GO:0042487,GO:0043065,GO:0043231,GO:0043410,GO:0043569,GO:0045165,GO:0045600,GO:0045666,GO:0045669,GO:0045778,GO:0045786,GO:0045892,GO:0045893,GO:0045944,GO:0046332,GO:0048711,GO:0048762,GO:0048839,GO:0051042,GO:0055007,GO:0055008,GO:0055114,GO:0060039,GO:0060128,GO:0060129,GO:0060317,GO:0060389,GO:0060395,GO:0060485,GO:0060804,GO:0061036,GO:0061312,GO:0070374,GO:0070700,GO:0070724,GO:0071407,GO:0071773,GO:0072138,GO:0090090,GO:1900745,GO:1901522,GO:1902895,GO:1905072,GO:1905222,GO:2000065,GO:2000726" "negative regulation of transcription by RNA polymerase II|activation of MAPK activity|skeletal system development|osteoblast differentiation|branching involved in ureteric bud morphogenesis|response to hypoxia|in utero embryonic development|epithelial to mesenchymal transition|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|chondrocyte differentiation|BMP signaling pathway involved in heart induction|aortic valve development|atrioventricular valve morphogenesis|endocardial cushion morphogenesis|cardiac atrium formation|endocardial cushion formation|negative regulation of Wnt signaling pathway involved in heart development|positive regulation of extracellular matrix constituent secretion|retinol dehydrogenase activity|signaling receptor binding|cytokine activity|protein binding|extracellular region|extracellular space|proteoglycan metabolic process|regulation of transcription, DNA-templated|protein phosphorylation|inflammatory response|Notch signaling pathway|cell-cell signaling|heart development|growth factor activity|negative regulation of cell population proliferation|response to bacterium|animal organ morphogenesis|cell surface|positive regulation of gene expression|negative regulation of gene expression|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of steroid biosynthetic process|positive regulation of phosphatase activity|phosphatase activator activity|telencephalon development|telencephalon regionalization|positive regulation of Wnt signaling pathway|bone mineralization|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|protein destabilization|positive regulation of protein binding|negative regulation of aldosterone biosynthetic process|positive regulation of osteoblast proliferation|cardiocyte differentiation|embryonic heart tube anterior/posterior pattern specification|bone mineralization involved in bone maturation|co-receptor binding|odontogenesis of dentin-containing tooth|positive regulation of odontogenesis|regulation of odontogenesis of dentin-containing tooth|positive regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of MAPK cascade|negative regulation of insulin-like growth factor receptor signaling pathway|cell fate commitment|positive regulation of fat cell differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of ossification|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|positive regulation of astrocyte differentiation|mesenchymal cell differentiation|inner ear development|negative regulation of calcium-independent cell-cell adhesion|cardiac muscle cell differentiation|cardiac muscle tissue morphogenesis|oxidation-reduction process|pericardium development|corticotropin hormone secreting cell differentiation|thyroid-stimulating hormone-secreting cell differentiation|cardiac epithelial to mesenchymal transition|pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|mesenchyme development|positive regulation of Wnt signaling pathway by BMP signaling pathway|positive regulation of cartilage development|BMP signaling pathway involved in heart development|positive regulation of ERK1 and ERK2 cascade|BMP receptor binding|BMP receptor complex|cellular response to organic cyclic compound|cellular response to BMP stimulus|mesenchymal cell proliferation involved in ureteric bud development|negative regulation of canonical Wnt signaling pathway|positive regulation of p38MAPK cascade|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of pri-miRNA transcription by RNA polymerase II|cardiac jelly development|atrioventricular canal morphogenesis|negative regulation of cortisol biosynthetic process|negative regulation of cardiac muscle cell differentiation" "hsa04060,hsa04350,hsa04390,hsa05200,hsa05217" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Pathways in cancer|Basal cell carcinoma BMP2K 772.7734175 763.2468882 782.2999467 1.024963166 0.035572064 0.926964534 1 4.63109648 4.951172036 55589 BMP2 inducible kinase "GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0016607,GO:0019208,GO:0030500,GO:0035612,GO:0045747,GO:0050790,GO:0106310,GO:0106311,GO:2000369" protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|nuclear speck|phosphatase regulator activity|regulation of bone mineralization|AP-2 adaptor complex binding|positive regulation of Notch signaling pathway|regulation of catalytic activity|protein serine kinase activity|protein threonine kinase activity|regulation of clathrin-dependent endocytosis hsa05202 Transcriptional misregulation in cancer BMP3 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.034897447 0.01766791 651 bone morphogenetic protein 3 "GO:0001501,GO:0001649,GO:0005102,GO:0005125,GO:0005615,GO:0007267,GO:0008083,GO:0010862,GO:0051216,GO:0060395,GO:0070062,GO:0070700" skeletal system development|osteoblast differentiation|signaling receptor binding|cytokine activity|extracellular space|cell-cell signaling|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|cartilage development|SMAD protein signal transduction|extracellular exosome|BMP receptor binding hsa04060 Cytokine-cytokine receptor interaction BMP4 5.493183171 5.074779842 5.911586499 1.164895165 0.220200125 1 1 0.103428449 0.125673232 652 bone morphogenetic protein 4 "GO:0000122,GO:0000186,GO:0001649,GO:0001657,GO:0001658,GO:0001822,GO:0001823,GO:0001843,GO:0001934,GO:0001938,GO:0001958,GO:0002043,GO:0002062,GO:0002244,GO:0002320,GO:0003014,GO:0003130,GO:0003139,GO:0003148,GO:0003149,GO:0003150,GO:0003180,GO:0003184,GO:0003197,GO:0003198,GO:0003215,GO:0003277,GO:0003279,GO:0003323,GO:0003337,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0007182,GO:0007281,GO:0007492,GO:0007500,GO:0008083,GO:0008201,GO:0008284,GO:0008285,GO:0009791,GO:0009948,GO:0010159,GO:0010453,GO:0010595,GO:0010628,GO:0010629,GO:0010718,GO:0010862,GO:0010942,GO:0021537,GO:0021904,GO:0021978,GO:0021983,GO:0030218,GO:0030224,GO:0030225,GO:0030501,GO:0030509,GO:0030513,GO:0032092,GO:0032331,GO:0032967,GO:0033085,GO:0033088,GO:0034504,GO:0035116,GO:0035990,GO:0035993,GO:0039706,GO:0042056,GO:0042306,GO:0042326,GO:0042475,GO:0042476,GO:0042487,GO:0042733,GO:0043065,GO:0043066,GO:0043401,GO:0043407,GO:0043687,GO:0044267,GO:0045603,GO:0045606,GO:0045662,GO:0045666,GO:0045669,GO:0045778,GO:0045786,GO:0045839,GO:0045843,GO:0045892,GO:0045893,GO:0045944,GO:0048286,GO:0048392,GO:0048661,GO:0048663,GO:0048701,GO:0048745,GO:0048754,GO:0050679,GO:0050680,GO:0050918,GO:0051150,GO:0055007,GO:0055020,GO:0060113,GO:0060197,GO:0060235,GO:0060272,GO:0060363,GO:0060391,GO:0060393,GO:0060395,GO:0060425,GO:0060433,GO:0060438,GO:0060440,GO:0060441,GO:0060442,GO:0060449,GO:0060502,GO:0060503,GO:0060548,GO:0060592,GO:0060684,GO:0060686,GO:0060687,GO:0060976,GO:0061036,GO:0061047,GO:0061149,GO:0061151,GO:0061155,GO:0061312,GO:0061626,GO:0070244,GO:0070374,GO:0070700,GO:0071773,GO:0071893,GO:0072015,GO:0072097,GO:0072101,GO:0072104,GO:0072125,GO:0072138,GO:0072161,GO:0072192,GO:0072193,GO:0072198,GO:0072200,GO:0072205,GO:0090184,GO:0090191,GO:0090194,GO:1901964,GO:1902893,GO:1902894,GO:1903800,GO:1905072,GO:1905312,GO:2000005,GO:2000007,GO:2000137,GO:2001237" "negative regulation of transcription by RNA polymerase II|activation of MAPKK activity|osteoblast differentiation|ureteric bud development|branching involved in ureteric bud morphogenesis|kidney development|mesonephros development|neural tube closure|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|endochondral ossification|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|chondrocyte differentiation|hematopoietic progenitor cell differentiation|lymphoid progenitor cell differentiation|renal system process|BMP signaling pathway involved in heart induction|secondary heart field specification|outflow tract septum morphogenesis|membranous septum morphogenesis|muscular septum morphogenesis|aortic valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion development|epithelial to mesenchymal transition involved in endocardial cushion formation|cardiac right ventricle morphogenesis|apoptotic process involved in endocardial cushion morphogenesis|cardiac septum development|type B pancreatic cell development|mesenchymal to epithelial transition involved in metanephros morphogenesis|cytokine activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|common-partner SMAD protein phosphorylation|germ cell development|endoderm development|mesodermal cell fate determination|growth factor activity|heparin binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|post-embryonic development|anterior/posterior axis specification|specification of animal organ position|regulation of cell fate commitment|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of cell death|telencephalon development|dorsal/ventral neural tube patterning|telencephalon regionalization|pituitary gland development|erythrocyte differentiation|monocyte differentiation|macrophage differentiation|positive regulation of bone mineralization|BMP signaling pathway|positive regulation of BMP signaling pathway|positive regulation of protein binding|negative regulation of chondrocyte differentiation|positive regulation of collagen biosynthetic process|negative regulation of T cell differentiation in thymus|negative regulation of immature T cell proliferation in thymus|protein localization to nucleus|embryonic hindlimb morphogenesis|tendon cell differentiation|deltoid tuberosity development|co-receptor binding|chemoattractant activity|regulation of protein import into nucleus|negative regulation of phosphorylation|odontogenesis of dentin-containing tooth|odontogenesis|regulation of odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|positive regulation of apoptotic process|negative regulation of apoptotic process|steroid hormone mediated signaling pathway|negative regulation of MAP kinase activity|post-translational protein modification|cellular protein metabolic process|positive regulation of endothelial cell differentiation|positive regulation of epidermal cell differentiation|negative regulation of myoblast differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of ossification|negative regulation of cell cycle|negative regulation of mitotic nuclear division|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lung alveolus development|intermediate mesodermal cell differentiation|positive regulation of smooth muscle cell proliferation|neuron fate commitment|embryonic cranial skeleton morphogenesis|smooth muscle tissue development|branching morphogenesis of an epithelial tube|positive regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|positive chemotaxis|regulation of smooth muscle cell differentiation|cardiac muscle cell differentiation|positive regulation of cardiac muscle fiber development|inner ear receptor cell differentiation|cloacal septation|lens induction in camera-type eye|embryonic skeletal joint morphogenesis|cranial suture morphogenesis|positive regulation of SMAD protein signal transduction|regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|lung morphogenesis|bronchus development|trachea development|trachea formation|epithelial tube branching involved in lung morphogenesis|branching involved in prostate gland morphogenesis|bud elongation involved in lung branching|epithelial cell proliferation involved in lung morphogenesis|bud dilation involved in lung branching|negative regulation of cell death|mammary gland formation|epithelial-mesenchymal cell signaling|negative regulation of prostatic bud formation|regulation of branching involved in prostate gland morphogenesis|coronary vasculature development|positive regulation of cartilage development|positive regulation of branching involved in lung morphogenesis|BMP signaling pathway involved in ureter morphogenesis|BMP signaling pathway involved in renal system segmentation|pulmonary artery endothelial tube morphogenesis|BMP signaling pathway involved in heart development|pharyngeal arch artery morphogenesis|negative regulation of thymocyte apoptotic process|positive regulation of ERK1 and ERK2 cascade|BMP receptor binding|cellular response to BMP stimulus|BMP signaling pathway involved in nephric duct formation|glomerular visceral epithelial cell development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|glomerular capillary formation|negative regulation of glomerular mesangial cell proliferation|mesenchymal cell proliferation involved in ureteric bud development|mesenchymal cell differentiation involved in kidney development|ureter epithelial cell differentiation|ureter smooth muscle cell differentiation|mesenchymal cell proliferation involved in ureter development|negative regulation of mesenchymal cell proliferation involved in ureter development|metanephric collecting duct development|positive regulation of kidney development|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of glomerulus development|positive regulation of cell proliferation involved in outflow tract morphogenesis|regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of production of miRNAs involved in gene silencing by miRNA|cardiac jelly development|positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of extrinsic apoptotic signaling pathway" "hsa04060,hsa04350,hsa04390,hsa04550,hsa04919,hsa05200,hsa05217,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Thyroid hormone signaling pathway|Pathways in cancer|Basal cell carcinoma|Fluid shear stress and atherosclerosis BMP6 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.054338202 0.04126559 654 bone morphogenetic protein 6 "GO:0000122,GO:0001501,GO:0001649,GO:0001654,GO:0001822,GO:0001938,GO:0001958,GO:0003323,GO:0005125,GO:0005615,GO:0005737,GO:0006879,GO:0006954,GO:0006955,GO:0008083,GO:0008284,GO:0010628,GO:0010862,GO:0014823,GO:0030501,GO:0030509,GO:0030539,GO:0031666,GO:0031982,GO:0032026,GO:0032332,GO:0032349,GO:0032526,GO:0043117,GO:0045603,GO:0045666,GO:0045669,GO:0045944,GO:0046982,GO:0050679,GO:0050714,GO:0050731,GO:0051216,GO:0051384,GO:0060391,GO:0060395,GO:0060586,GO:0070700,GO:0071260,GO:0071281,GO:0071773,GO:1903392,GO:2000048,GO:2000860" negative regulation of transcription by RNA polymerase II|skeletal system development|osteoblast differentiation|eye development|kidney development|positive regulation of endothelial cell proliferation|endochondral ossification|type B pancreatic cell development|cytokine activity|extracellular space|cytoplasm|cellular iron ion homeostasis|inflammatory response|immune response|growth factor activity|positive regulation of cell population proliferation|positive regulation of gene expression|positive regulation of pathway-restricted SMAD protein phosphorylation|response to activity|positive regulation of bone mineralization|BMP signaling pathway|male genitalia development|positive regulation of lipopolysaccharide-mediated signaling pathway|vesicle|response to magnesium ion|positive regulation of chondrocyte differentiation|positive regulation of aldosterone biosynthetic process|response to retinoic acid|positive regulation of vascular permeability|positive regulation of endothelial cell differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of epithelial cell proliferation|positive regulation of protein secretion|positive regulation of peptidyl-tyrosine phosphorylation|cartilage development|response to glucocorticoid|positive regulation of SMAD protein signal transduction|SMAD protein signal transduction|multicellular organismal iron ion homeostasis|BMP receptor binding|cellular response to mechanical stimulus|cellular response to iron ion|cellular response to BMP stimulus|negative regulation of adherens junction organization|negative regulation of cell-cell adhesion mediated by cadherin|positive regulation of aldosterone secretion "hsa04060,hsa04350,hsa04390,hsa04913" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Ovarian steroidogenesis BMP8B 5.015396738 6.08973581 3.941057666 0.64716398 -0.627796782 0.826813936 1 0.051748932 0.03493266 656 bone morphogenetic protein 8b "GO:0001501,GO:0001503,GO:0005125,GO:0005615,GO:0008083,GO:0010862,GO:0030154,GO:0030509,GO:0051216,GO:0060395,GO:0070700" skeletal system development|ossification|cytokine activity|extracellular space|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|cell differentiation|BMP signaling pathway|cartilage development|SMAD protein signal transduction|BMP receptor binding "hsa04060,hsa04350,hsa04390,hsa04714" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Thermogenesis BMPER 48.46822989 46.68797455 50.24848524 1.076261837 0.106029105 0.926078968 1 0.423608242 0.475552284 168667 BMP binding endothelial regulator "GO:0001568,GO:0001657,GO:0002043,GO:0005615,GO:0010594,GO:0030514,GO:0031012,GO:0042118,GO:0045765,GO:0048839,GO:0060393,GO:0070374,GO:1903672" blood vessel development|ureteric bud development|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|extracellular space|regulation of endothelial cell migration|negative regulation of BMP signaling pathway|extracellular matrix|endothelial cell activation|regulation of angiogenesis|inner ear development|regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of ERK1 and ERK2 cascade|positive regulation of sprouting angiogenesis BMPR1A 1800.168655 1824.890831 1775.446479 0.972905583 -0.039628291 0.904595186 1 13.79466907 13.99902896 657 bone morphogenetic protein receptor type 1A "GO:0001701,GO:0001707,GO:0001756,GO:0001880,GO:0002053,GO:0002062,GO:0003148,GO:0003151,GO:0003161,GO:0003183,GO:0003186,GO:0003203,GO:0003215,GO:0003222,GO:0003223,GO:0003272,GO:0004674,GO:0004675,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0005901,GO:0006468,GO:0006955,GO:0007179,GO:0007398,GO:0009897,GO:0009950,GO:0009953,GO:0010665,GO:0010862,GO:0014032,GO:0014912,GO:0016021,GO:0019827,GO:0021983,GO:0021998,GO:0030324,GO:0030425,GO:0030501,GO:0030509,GO:0035137,GO:0035912,GO:0042475,GO:0042733,GO:0042803,GO:0043025,GO:0043235,GO:0045669,GO:0045944,GO:0046332,GO:0046872,GO:0048352,GO:0048368,GO:0048378,GO:0048382,GO:0048568,GO:0048589,GO:0050679,GO:0050768,GO:0060021,GO:0060043,GO:0060045,GO:0060391,GO:0060914,GO:0061312,GO:0061626,GO:0071363,GO:0071773,GO:0098821,GO:1902895,GO:1904414,GO:1904707,GO:1905285,GO:1905292,GO:1990712,GO:2000772" "in utero embryonic development|mesoderm formation|somitogenesis|Mullerian duct regression|positive regulation of mesenchymal cell proliferation|chondrocyte differentiation|outflow tract septum morphogenesis|outflow tract morphogenesis|cardiac conduction system development|mitral valve morphogenesis|tricuspid valve morphogenesis|endocardial cushion morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|ventricular compact myocardium morphogenesis|endocardial cushion formation|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta receptor activity, type I|protein binding|ATP binding|plasma membrane|caveola|protein phosphorylation|immune response|transforming growth factor beta receptor signaling pathway|ectoderm development|external side of plasma membrane|dorsal/ventral axis specification|dorsal/ventral pattern formation|regulation of cardiac muscle cell apoptotic process|positive regulation of pathway-restricted SMAD protein phosphorylation|neural crest cell development|negative regulation of smooth muscle cell migration|integral component of membrane|stem cell population maintenance|pituitary gland development|neural plate mediolateral regionalization|lung development|dendrite|positive regulation of bone mineralization|BMP signaling pathway|hindlimb morphogenesis|dorsal aorta morphogenesis|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|protein homodimerization activity|neuronal cell body|receptor complex|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|paraxial mesoderm structural organization|lateral mesoderm development|regulation of lateral mesodermal cell fate specification|mesendoderm development|embryonic organ development|developmental growth|positive regulation of epithelial cell proliferation|negative regulation of neurogenesis|roof of mouth development|regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle cell proliferation|positive regulation of SMAD protein signal transduction|heart formation|BMP signaling pathway involved in heart development|pharyngeal arch artery morphogenesis|cellular response to growth factor stimulus|cellular response to BMP stimulus|BMP receptor activity|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of cardiac ventricle development|positive regulation of vascular associated smooth muscle cell proliferation|fibrous ring of heart morphogenesis|regulation of neural crest cell differentiation|HFE-transferrin receptor complex|regulation of cellular senescence" "hsa04060,hsa04350,hsa04390,hsa04550,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis BMPR1B 44.31933137 32.47859099 56.16007174 1.72914126 0.790055733 0.373506511 1 0.249723099 0.450406988 658 bone morphogenetic protein receptor type 1B "GO:0001501,GO:0001502,GO:0001550,GO:0001654,GO:0002063,GO:0004674,GO:0004675,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0006468,GO:0006954,GO:0009953,GO:0030166,GO:0030425,GO:0030501,GO:0030509,GO:0031290,GO:0032332,GO:0035108,GO:0042698,GO:0043025,GO:0043235,GO:0045597,GO:0045669,GO:0045944,GO:0046332,GO:0046872,GO:0060041,GO:0060350,GO:0061036,GO:0071363,GO:0071773,GO:1902043,GO:1902731,GO:1990712" "skeletal system development|cartilage condensation|ovarian cumulus expansion|eye development|chondrocyte development|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta receptor activity, type I|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|protein phosphorylation|inflammatory response|dorsal/ventral pattern formation|proteoglycan biosynthetic process|dendrite|positive regulation of bone mineralization|BMP signaling pathway|retinal ganglion cell axon guidance|positive regulation of chondrocyte differentiation|limb morphogenesis|ovulation cycle|neuronal cell body|receptor complex|positive regulation of cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|retina development in camera-type eye|endochondral bone morphogenesis|positive regulation of cartilage development|cellular response to growth factor stimulus|cellular response to BMP stimulus|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of chondrocyte proliferation|HFE-transferrin receptor complex" "hsa04060,hsa04350,hsa04360,hsa04390,hsa04550,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis BMPR2 1992.453076 1903.042441 2081.863712 1.093965992 0.12956789 0.688508487 1 7.974053619 9.099109739 659 bone morphogenetic protein receptor type 2 "GO:0001568,GO:0001707,GO:0001893,GO:0001935,GO:0001938,GO:0001946,GO:0001974,GO:0002063,GO:0003085,GO:0003148,GO:0003151,GO:0003176,GO:0003177,GO:0003181,GO:0003183,GO:0003186,GO:0003197,GO:0003252,GO:0004674,GO:0005024,GO:0005515,GO:0005524,GO:0005615,GO:0005654,GO:0005737,GO:0005886,GO:0005887,GO:0005901,GO:0005912,GO:0006468,GO:0007178,GO:0007420,GO:0009267,GO:0009925,GO:0009952,GO:0009986,GO:0010595,GO:0010634,GO:0010862,GO:0014069,GO:0014916,GO:0016324,GO:0016362,GO:0019838,GO:0030166,GO:0030308,GO:0030425,GO:0030501,GO:0030509,GO:0030513,GO:0032924,GO:0036122,GO:0042127,GO:0043025,GO:0043235,GO:0044214,GO:0045296,GO:0045669,GO:0045778,GO:0045906,GO:0045944,GO:0046872,GO:0048286,GO:0048738,GO:0048842,GO:0060173,GO:0060350,GO:0060412,GO:0060413,GO:0060836,GO:0060840,GO:0060841,GO:0061036,GO:0061298,GO:0061626,GO:0071363,GO:0071773,GO:0072577,GO:0098821,GO:1902731,GO:1905314,GO:1990782,GO:2000279" "blood vessel development|mesoderm formation|maternal placenta development|endothelial cell proliferation|positive regulation of endothelial cell proliferation|lymphangiogenesis|blood vessel remodeling|chondrocyte development|negative regulation of systemic arterial blood pressure|outflow tract septum morphogenesis|outflow tract morphogenesis|aortic valve development|pulmonary valve development|atrioventricular valve morphogenesis|mitral valve morphogenesis|tricuspid valve morphogenesis|endocardial cushion development|negative regulation of cell proliferation involved in heart valve morphogenesis|protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|protein binding|ATP binding|extracellular space|nucleoplasm|cytoplasm|plasma membrane|integral component of plasma membrane|caveola|adherens junction|protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|brain development|cellular response to starvation|basal plasma membrane|anterior/posterior pattern specification|cell surface|positive regulation of endothelial cell migration|positive regulation of epithelial cell migration|positive regulation of pathway-restricted SMAD protein phosphorylation|postsynaptic density|regulation of lung blood pressure|apical plasma membrane|activin receptor activity, type II|growth factor binding|proteoglycan biosynthetic process|negative regulation of cell growth|dendrite|positive regulation of bone mineralization|BMP signaling pathway|positive regulation of BMP signaling pathway|activin receptor signaling pathway|BMP binding|regulation of cell population proliferation|neuronal cell body|receptor complex|spanning component of plasma membrane|cadherin binding|positive regulation of osteoblast differentiation|positive regulation of ossification|negative regulation of vasoconstriction|positive regulation of transcription by RNA polymerase II|metal ion binding|lung alveolus development|cardiac muscle tissue development|positive regulation of axon extension involved in axon guidance|limb development|endochondral bone morphogenesis|ventricular septum morphogenesis|atrial septum morphogenesis|lymphatic endothelial cell differentiation|artery development|venous blood vessel development|positive regulation of cartilage development|retina vasculature development in camera-type eye|pharyngeal arch artery morphogenesis|cellular response to growth factor stimulus|cellular response to BMP stimulus|endothelial cell apoptotic process|BMP receptor activity|negative regulation of chondrocyte proliferation|semi-lunar valve development|protein tyrosine kinase binding|negative regulation of DNA biosynthetic process" "hsa04060,hsa04350,hsa04360,hsa04390,hsa04550,hsa05206,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|MicroRNAs in cancer|Fluid shear stress and atherosclerosis BMS1 2337.781081 2542.464701 2133.097462 0.838988034 -0.25327786 0.428286983 1 28.40654485 24.8593695 9790 BMS1 ribosome biogenesis factor "GO:0000462,GO:0000479,GO:0003723,GO:0003924,GO:0005524,GO:0005525,GO:0005654,GO:0005694,GO:0005730,GO:0006364,GO:0030686,GO:0034511" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|GTPase activity|ATP binding|GTP binding|nucleoplasm|chromosome|nucleolus|rRNA processing|90S preribosome|U3 snoRNA binding" hsa03008 Ribosome biogenesis in eukaryotes BMT2 175.3755823 201.9762377 148.7749269 0.736596189 -0.441054162 0.435116167 1 2.596290333 1.994796756 154743 base methyltransferase of 25S rRNA 2 homolog "GO:0005730,GO:0016433,GO:0031167,GO:0034198,GO:0140007,GO:1904047,GO:1904262,GO:1990130" nucleolus|rRNA (adenine) methyltransferase activity|rRNA methylation|cellular response to amino acid starvation|KICSTOR complex|S-adenosyl-L-methionine binding|negative regulation of TORC1 signaling|GATOR1 complex BNC1 372.9817187 374.5187523 371.444685 0.991791954 -0.011890574 0.985386328 1 3.762756116 3.892625118 646 basonuclin 1 "GO:0000182,GO:0000976,GO:0001216,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006355,GO:0006356,GO:0007283,GO:0008284,GO:0008544,GO:0030154,GO:0043231,GO:0045943,GO:0046872,GO:1900195" "rDNA binding|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity|nucleus|nucleoplasm|nucleolus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase I|spermatogenesis|positive regulation of cell population proliferation|epidermis development|cell differentiation|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase I|metal ion binding|positive regulation of oocyte maturation" BNC2 443.9153135 441.5058462 446.3247807 1.010914769 0.015661368 0.976293501 1 1.723103458 1.816945185 54796 basonuclin 2 "GO:0000976,GO:0003416,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0043586,GO:0046872,GO:0060021,GO:0060485" "transcription regulatory region sequence-specific DNA binding|endochondral bone growth|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|tongue development|metal ion binding|roof of mouth development|mesenchyme development" BNIP1 259.2512265 278.0979353 240.4045176 0.864459915 -0.210129027 0.675889897 1 9.503832223 8.569580259 662 BCL2 interacting protein 1 "GO:0005484,GO:0005515,GO:0005635,GO:0005737,GO:0005783,GO:0005789,GO:0006890,GO:0006915,GO:0007029,GO:0014823,GO:0016032,GO:0016320,GO:0030137,GO:0030176,GO:0031201,GO:0031966,GO:0042594,GO:0043066,GO:0043231,GO:0090649,GO:0097194" "SNAP receptor activity|protein binding|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|apoptotic process|endoplasmic reticulum organization|response to activity|viral process|endoplasmic reticulum membrane fusion|COPI-coated vesicle|integral component of endoplasmic reticulum membrane|SNARE complex|mitochondrial membrane|response to starvation|negative regulation of apoptotic process|intracellular membrane-bounded organelle|response to oxygen-glucose deprivation|execution phase of apoptosis" hsa04130 SNARE interactions in vesicular transport BNIP2 1462.652496 1315.382935 1609.922057 1.223918917 0.291507984 0.38097853 1 10.50449468 13.41046208 663 BCL2 interacting protein 2 "GO:0004309,GO:0005096,GO:0005509,GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0006798,GO:0006915,GO:0043066,GO:0043231,GO:0043547,GO:0048471,GO:0051149" exopolyphosphatase activity|GTPase activator activity|calcium ion binding|protein binding|nuclear envelope|cytoplasm|cytosol|polyphosphate catabolic process|apoptotic process|negative regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of GTPase activity|perinuclear region of cytoplasm|positive regulation of muscle cell differentiation BNIP3 1546.15502 2309.024828 783.2852112 0.339227713 -1.559674061 3.84E-06 0.001156494 75.83914513 26.83494335 664 BCL2 interacting protein 3 "GO:0000422,GO:0001666,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005783,GO:0006915,GO:0008219,GO:0009617,GO:0010508,GO:0010637,GO:0010659,GO:0010666,GO:0010917,GO:0010940,GO:0014069,GO:0016032,GO:0016239,GO:0021987,GO:0030425,GO:0031307,GO:0031966,GO:0035694,GO:0042802,GO:0042803,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043243,GO:0043653,GO:0045837,GO:0046902,GO:0048102,GO:0048678,GO:0048709,GO:0050873,GO:0051020,GO:0051402,GO:0051561,GO:0051607,GO:0055093,GO:0060548,GO:0070301,GO:0071260,GO:0071279,GO:0071456,GO:0072593,GO:0090141,GO:0090200,GO:0090649,GO:0097345,GO:0140507,GO:1901998,GO:1902109,GO:1903599,GO:1903715,GO:1990144,GO:2000378" autophagy of mitochondrion|response to hypoxia|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|apoptotic process|cell death|response to bacterium|positive regulation of autophagy|negative regulation of mitochondrial fusion|cardiac muscle cell apoptotic process|positive regulation of cardiac muscle cell apoptotic process|negative regulation of mitochondrial membrane potential|positive regulation of necrotic cell death|postsynaptic density|viral process|positive regulation of macroautophagy|cerebral cortex development|dendrite|integral component of mitochondrial outer membrane|mitochondrial membrane|mitochondrial protein catabolic process|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of programmed cell death|positive regulation of programmed cell death|positive regulation of protein-containing complex disassembly|mitochondrial fragmentation involved in apoptotic process|negative regulation of membrane potential|regulation of mitochondrial membrane permeability|autophagic cell death|response to axon injury|oligodendrocyte differentiation|brown fat cell differentiation|GTPase binding|neuron apoptotic process|positive regulation of mitochondrial calcium ion concentration|defense response to virus|response to hyperoxia|negative regulation of cell death|cellular response to hydrogen peroxide|cellular response to mechanical stimulus|cellular response to cobalt ion|cellular response to hypoxia|reactive oxygen species metabolic process|positive regulation of mitochondrial fission|positive regulation of release of cytochrome c from mitochondria|response to oxygen-glucose deprivation|mitochondrial outer membrane permeabilization|granzyme-mediated programmed cell death signaling pathway|toxin transport|negative regulation of mitochondrial membrane permeability involved in apoptotic process|positive regulation of autophagy of mitochondrion|regulation of aerobic respiration|intrinsic apoptotic signaling pathway in response to hypoxia|negative regulation of reactive oxygen species metabolic process "hsa04068,hsa04137,hsa04140,hsa05131,hsa05134" FoxO signaling pathway|Mitophagy - animal|Autophagy - animal|Shigellosis|Legionellosis BNIP3L 2643.305838 3054.002509 2232.609168 0.731043659 -0.451970527 0.156456043 1 43.48452437 33.15843069 665 BCL2 interacting protein 3 like "GO:0005515,GO:0005521,GO:0005634,GO:0005635,GO:0005739,GO:0005741,GO:0005783,GO:0005829,GO:0010917,GO:0016021,GO:0016032,GO:0016239,GO:0016607,GO:0031224,GO:0035694,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0051607,GO:0060548,GO:0071456,GO:0097345,GO:1903146,GO:1903214" protein binding|lamin binding|nucleus|nuclear envelope|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|cytosol|negative regulation of mitochondrial membrane potential|integral component of membrane|viral process|positive regulation of macroautophagy|nuclear speck|intrinsic component of membrane|mitochondrial protein catabolic process|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of programmed cell death|defense response to virus|negative regulation of cell death|cellular response to hypoxia|mitochondrial outer membrane permeabilization|regulation of autophagy of mitochondrion|regulation of protein targeting to mitochondrion hsa04137 Mitophagy - animal BNIPL 8.493513748 8.119647747 8.867379749 1.092089217 0.12709072 1 1 0.164624305 0.187528812 149428 BCL2 interacting protein like "GO:0004309,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006798,GO:0006915,GO:0008285,GO:0040009,GO:0042802" exopolyphosphatase activity|protein binding|nucleus|cytoplasm|cytosol|polyphosphate catabolic process|apoptotic process|negative regulation of cell population proliferation|regulation of growth rate|identical protein binding BOC 178.1559478 156.3032191 200.0086766 1.279619688 0.355715095 0.528462127 1 1.437480778 1.918663834 91653 "BOC cell adhesion associated, oncogene regulated" "GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007224,GO:0007411,GO:0044295,GO:0045663,GO:0051149" protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|smoothened signaling pathway|axon guidance|axonal growth cone|positive regulation of myoblast differentiation|positive regulation of muscle cell differentiation "hsa04340,hsa04360" Hedgehog signaling pathway|Axon guidance BOD1 1379.551554 1258.545401 1500.557706 1.192295252 0.25374154 0.449382588 1 27.20481633 33.83339216 91272 biorientation of chromosomes in cell division 1 "GO:0000922,GO:0000940,GO:0004864,GO:0005737,GO:0005813,GO:0005876,GO:0007080,GO:0032515,GO:0051301,GO:0051721,GO:0071459,GO:0071962,GO:1990758" "spindle pole|condensed chromosome outer kinetochore|protein phosphatase inhibitor activity|cytoplasm|centrosome|spindle microtubule|mitotic metaphase plate congression|negative regulation of phosphoprotein phosphatase activity|cell division|protein phosphatase 2A binding|protein localization to chromosome, centromeric region|mitotic sister chromatid cohesion, centromeric|mitotic sister chromatid biorientation" BOD1L1 1566.596408 1517.359173 1615.833643 1.06489859 0.090716049 0.784655553 1 7.136121198 7.926590071 259282 biorientation of chromosomes in cell division 1 like 1 "GO:0000922,GO:0000940,GO:0004864,GO:0005515,GO:0005654,GO:0005813,GO:0005876,GO:0006281,GO:0006974,GO:0031297,GO:0032515,GO:0051721" spindle pole|condensed chromosome outer kinetochore|protein phosphatase inhibitor activity|protein binding|nucleoplasm|centrosome|spindle microtubule|DNA repair|cellular response to DNA damage stimulus|replication fork processing|negative regulation of phosphoprotein phosphatase activity|protein phosphatase 2A binding BOK 878.1467295 827.1891142 929.1043448 1.123206687 0.16762343 0.643724391 1 14.37194185 16.83802157 666 BCL2 family apoptosis regulator BOK "GO:0001836,GO:0005102,GO:0005515,GO:0005634,GO:0005640,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005783,GO:0005789,GO:0005794,GO:0006915,GO:0006919,GO:0006921,GO:0007420,GO:0008584,GO:0008630,GO:0008635,GO:0010506,GO:0016021,GO:0031625,GO:0031901,GO:0031966,GO:0032588,GO:0033106,GO:0042803,GO:0043065,GO:0043524,GO:0044877,GO:0046982,GO:0048709,GO:0051259,GO:0051400,GO:0051402,GO:0051480,GO:0051902,GO:0055038,GO:0060546,GO:0072332,GO:0097192,GO:1900119,GO:1901029,GO:1901030,GO:1901382,GO:1902237,GO:1903899,GO:1904708,GO:2001244" release of cytochrome c from mitochondria|signaling receptor binding|protein binding|nucleus|nuclear outer membrane|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular component disassembly involved in execution phase of apoptosis|brain development|male gonad development|intrinsic apoptotic signaling pathway in response to DNA damage|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|regulation of autophagy|integral component of membrane|ubiquitin protein ligase binding|early endosome membrane|mitochondrial membrane|trans-Golgi network membrane|cis-Golgi network membrane|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of neuron apoptotic process|protein-containing complex binding|protein heterodimerization activity|oligodendrocyte differentiation|protein complex oligomerization|BH domain binding|neuron apoptotic process|regulation of cytosolic calcium ion concentration|negative regulation of mitochondrial depolarization|recycling endosome membrane|negative regulation of necroptotic process|intrinsic apoptotic signaling pathway by p53 class mediator|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of execution phase of apoptosis|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|regulation of chorionic trophoblast cell proliferation|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of PERK-mediated unfolded protein response|regulation of granulosa cell apoptotic process|positive regulation of intrinsic apoptotic signaling pathway hsa04215 Apoptosis - multiple species BOLA1 41.94524498 38.5683268 45.32216316 1.175113543 0.232800161 0.816642046 1 1.750313344 2.145416246 51027 bolA family member 1 "GO:0005515,GO:0005739" protein binding|mitochondrion BOLA2-SMG1P6 24.10656505 31.46363502 16.74949508 0.532344564 -0.90956775 0.39481526 1 0.773554426 0.42953606 107282092 BOLA2-SMG1P6 readthrough BOLA2B 40.27163166 58.86744617 21.67581716 0.368213989 -1.441383658 0.115038479 1 7.950475937 3.053580271 654483 bolA family member 2B "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006879,GO:0035722,GO:0044571,GO:0051536,GO:0097428" protein binding|nucleus|cytoplasm|cytosol|cellular iron ion homeostasis|interleukin-12-mediated signaling pathway|[2Fe-2S] cluster assembly|iron-sulfur cluster binding|protein maturation by iron-sulfur cluster transfer BOLA3 192.1993063 207.0510175 177.347595 0.856540562 -0.223406527 0.688047823 1 18.89442091 16.88097201 388962 bolA family member 3 "GO:0003674,GO:0005515,GO:0005739,GO:0005829,GO:0008150,GO:0016604" molecular_function|protein binding|mitochondrion|cytosol|biological_process|nuclear body BOP1 1572.002992 1853.309598 1290.696386 0.696427832 -0.521954235 0.113703381 1 38.65881098 28.08280867 23246 BOP1 ribosomal biogenesis factor "GO:0000027,GO:0000448,GO:0000463,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0006364,GO:0008283,GO:0030687,GO:0042254,GO:0043021,GO:0051726,GO:0070545,GO:1901796,GO:1990904" "ribosomal large subunit assembly|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|rRNA processing|cell population proliferation|preribosome, large subunit precursor|ribosome biogenesis|ribonucleoprotein complex binding|regulation of cell cycle|PeBoW complex|regulation of signal transduction by p53 class mediator|ribonucleoprotein complex" BORA 405.5548275 378.5785762 432.5310789 1.142513354 0.192211028 0.659425311 1 6.946981645 8.278913901 79866 BORA aurora kinase A activator "GO:0000086,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007088,GO:0019901,GO:0032147,GO:0032880,GO:0051301,GO:0060236" G2/M transition of mitotic cell cycle|protein binding|nucleus|cytoplasm|cytosol|regulation of mitotic nuclear division|protein kinase binding|activation of protein kinase activity|regulation of protein localization|cell division|regulation of mitotic spindle organization BORCS5 166.3745906 192.841634 139.9075471 0.725504883 -0.46294277 0.420622956 1 1.591453228 1.204342879 118426 BLOC-1 related complex subunit 5 "GO:0005515,GO:0005873,GO:0005886,GO:0030672,GO:0031224,GO:0032418,GO:0043231,GO:0072384,GO:0098574,GO:0099078,GO:1903744" protein binding|plus-end kinesin complex|plasma membrane|synaptic vesicle membrane|intrinsic component of membrane|lysosome localization|intracellular membrane-bounded organelle|organelle transport along microtubule|cytoplasmic side of lysosomal membrane|BORC complex|positive regulation of anterograde synaptic vesicle transport BORCS6 179.423282 175.5873825 183.2591815 1.0436922 0.061696302 0.922186419 1 4.843617369 5.273005147 54785 BLOC-1 related complex subunit 6 "GO:0005515,GO:0005765,GO:0032418,GO:0042802,GO:0099078" protein binding|lysosomal membrane|lysosome localization|identical protein binding|BORC complex BORCS7 186.7682278 172.5425146 200.993941 1.164895165 0.220200125 0.695418584 1 5.648784533 6.863691917 119032 BLOC-1 related complex subunit 7 "GO:0005515,GO:0005765,GO:0099078" protein binding|lysosomal membrane|BORC complex BORCS8 116.0127823 117.7348923 114.2906723 0.970745971 -0.042834281 0.961557787 1 3.530406722 3.574754879 729991 BLOC-1 related complex subunit 8 "GO:0005515,GO:0005765,GO:0007507,GO:0099078" protein binding|lysosomal membrane|heart development|BORC complex BPGM 266.7891674 288.247495 245.3308397 0.851111784 -0.232579469 0.63948778 1 5.865294796 5.207057558 669 bisphosphoglycerate mutase "GO:0004082,GO:0004619,GO:0005515,GO:0005829,GO:0005975,GO:0007585,GO:0016787,GO:0048821,GO:0061621,GO:0070062" bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein binding|cytosol|carbohydrate metabolic process|respiratory gaseous exchange by respiratory system|hydrolase activity|erythrocyte development|canonical glycolysis|extracellular exosome "hsa00010,hsa00260" "Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism" BPHL 332.737057 351.1747651 314.2993489 0.894994117 -0.160049895 0.731062525 1 7.194887937 6.716764855 670 biphenyl hydrolase like "GO:0005739,GO:0005741,GO:0006520,GO:0006805,GO:0009636,GO:0047658" mitochondrion|mitochondrial outer membrane|cellular amino acid metabolic process|xenobiotic metabolic process|response to toxic substance|alpha-amino-acid esterase activity BPNT1 953.1131782 866.772397 1039.453959 1.199223652 0.262100743 0.461384263 1 11.70326956 14.63940155 10380 "3'(2'), 5'-bisphosphate nucleotidase 1" "GO:0005829,GO:0006139,GO:0007399,GO:0008441,GO:0046854,GO:0046855,GO:0046872,GO:0050427" "cytosol|nucleobase-containing compound metabolic process|nervous system development|3'(2'),5'-bisphosphate nucleotidase activity|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|metal ion binding|3'-phosphoadenosine 5'-phosphosulfate metabolic process" hsa00920 Sulfur metabolism BPNT2 7111.343156 7860.833975 6361.852338 0.809310101 -0.305235493 0.35206046 1 55.11122778 46.52334974 54928 "3'(2'), 5'-bisphosphate nucleotidase 2" "GO:0001501,GO:0001958,GO:0002063,GO:0005654,GO:0005794,GO:0005796,GO:0005829,GO:0008254,GO:0008441,GO:0009791,GO:0012505,GO:0016020,GO:0016021,GO:0016604,GO:0030204,GO:0032588,GO:0042733,GO:0046854,GO:0046855,GO:0046872,GO:0050427,GO:0097657" "skeletal system development|endochondral ossification|chondrocyte development|nucleoplasm|Golgi apparatus|Golgi lumen|cytosol|3'-nucleotidase activity|3'(2'),5'-bisphosphate nucleotidase activity|post-embryonic development|endomembrane system|membrane|integral component of membrane|nuclear body|chondroitin sulfate metabolic process|trans-Golgi network membrane|embryonic digit morphogenesis|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|metal ion binding|3'-phosphoadenosine 5'-phosphosulfate metabolic process|3',5'-nucleotide bisphosphate phosphatase activity" "hsa00920,hsa04070" Sulfur metabolism|Phosphatidylinositol signaling system BPTF 3774.998811 4005.016251 3544.981371 0.885135327 -0.176030051 0.580566394 1 15.52544541 14.33407501 2186 bromodomain PHD finger transcription factor "GO:0000122,GO:0000785,GO:0000978,GO:0001892,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006338,GO:0006357,GO:0007420,GO:0007492,GO:0008094,GO:0008134,GO:0009611,GO:0009952,GO:0016589,GO:0030425,GO:0035064,GO:0042766,GO:0043565,GO:0044297,GO:0045944,GO:0046872,GO:0048471,GO:0070062,GO:1990090" negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|embryonic placenta development|protein binding|nucleus|nucleoplasm|cytoplasm|chromatin remodeling|regulation of transcription by RNA polymerase II|brain development|endoderm development|DNA-dependent ATPase activity|transcription factor binding|response to wounding|anterior/posterior pattern specification|NURF complex|dendrite|methylated histone binding|nucleosome mobilization|sequence-specific DNA binding|cell body|positive regulation of transcription by RNA polymerase II|metal ion binding|perinuclear region of cytoplasm|extracellular exosome|cellular response to nerve growth factor stimulus chromosome_remodelling_factor BRAF 993.3914909 1027.13544 959.6475417 0.934295035 -0.098049894 0.783162789 1 3.140214084 3.060266356 673 "B-Raf proto-oncogene, serine/threonine kinase" "GO:0000165,GO:0000186,GO:0004672,GO:0004674,GO:0005509,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005886,GO:0006468,GO:0007173,GO:0009887,GO:0010628,GO:0010828,GO:0031267,GO:0033138,GO:0042802,GO:0043066,GO:0043231,GO:0070374,GO:0070413,GO:0071277,GO:0090150,GO:0097110,GO:0106310,GO:0106311" MAPK cascade|activation of MAPKK activity|protein kinase activity|protein serine/threonine kinase activity|calcium ion binding|protein binding|ATP binding|nucleus|cytosol|plasma membrane|protein phosphorylation|epidermal growth factor receptor signaling pathway|animal organ morphogenesis|positive regulation of gene expression|positive regulation of glucose transmembrane transport|small GTPase binding|positive regulation of peptidyl-serine phosphorylation|identical protein binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of ERK1 and ERK2 cascade|trehalose metabolism in response to stress|cellular response to calcium ion|establishment of protein localization to membrane|scaffold protein binding|protein serine kinase activity|protein threonine kinase activity "hsa01521,hsa01522,hsa04010,hsa04012,hsa04015,hsa04024,hsa04062,hsa04068,hsa04150,hsa04270,hsa04510,hsa04650,hsa04720,hsa04722,hsa04726,hsa04730,hsa04810,hsa04910,hsa04914,hsa04928,hsa04934,hsa05010,hsa05022,hsa05034,hsa05160,hsa05161,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|mTOR signaling pathway|Vascular smooth muscle contraction|Focal adhesion|Natural killer cell mediated cytotoxicity|Long-term potentiation|Neurotrophin signaling pathway|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Hepatitis C|Hepatitis B|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" BRAP 581.5742214 557.2108266 605.9376162 1.087447672 0.12094598 0.761888641 1 6.696906181 7.59623711 8315 BRCA1 associated protein "GO:0000151,GO:0000165,GO:0003676,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007265,GO:0008139,GO:0008270,GO:0009968,GO:0016567,GO:0031965,GO:0042802,GO:0061630" ubiquitin ligase complex|MAPK cascade|nucleic acid binding|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|Ras protein signal transduction|nuclear localization sequence binding|zinc ion binding|negative regulation of signal transduction|protein ubiquitination|nuclear membrane|identical protein binding|ubiquitin protein ligase activity hsa04014 Ras signaling pathway BRAT1 849.1705039 833.27885 865.0621577 1.038142463 0.054004437 0.884806974 1 11.30225874 12.23878006 221927 BRCA1 associated ATM activator 1 "GO:0001934,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006006,GO:0006915,GO:0006974,GO:0008283,GO:0010212,GO:0016020,GO:0016477,GO:0030307,GO:0051646" positive regulation of protein phosphorylation|protein binding|nucleus|nucleoplasm|cytoplasm|glucose metabolic process|apoptotic process|cellular response to DNA damage stimulus|cell population proliferation|response to ionizing radiation|membrane|cell migration|positive regulation of cell growth|mitochondrion localization BRCA1 1671.154686 1323.502583 2018.80679 1.525351606 0.609141834 0.063331175 1 9.373617226 14.91396461 672 BRCA1 DNA repair associated "GO:0000151,GO:0000724,GO:0000729,GO:0000800,GO:0000976,GO:0003677,GO:0003684,GO:0003713,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005886,GO:0006260,GO:0006301,GO:0006302,GO:0006303,GO:0006349,GO:0006357,GO:0006359,GO:0006633,GO:0006915,GO:0006974,GO:0006978,GO:0007059,GO:0007098,GO:0008270,GO:0008274,GO:0008630,GO:0009048,GO:0010212,GO:0010575,GO:0010628,GO:0015631,GO:0016567,GO:0016579,GO:0016604,GO:0019899,GO:0031398,GO:0031436,GO:0031625,GO:0032991,GO:0033147,GO:0035066,GO:0035067,GO:0042127,GO:0042802,GO:0042981,GO:0043009,GO:0043627,GO:0044030,GO:0044818,GO:0045717,GO:0045739,GO:0045766,GO:0045892,GO:0045893,GO:0045944,GO:0046600,GO:0051571,GO:0051572,GO:0051573,GO:0051574,GO:0051865,GO:0070063,GO:0070317,GO:0070512,GO:0070531,GO:0071158,GO:0071356,GO:0071681,GO:0072425,GO:0085020,GO:1901796,GO:1902042,GO:1990904,GO:2000378,GO:2000617,GO:2000620" "ubiquitin ligase complex|double-strand break repair via homologous recombination|DNA double-strand break processing|lateral element|transcription regulatory region sequence-specific DNA binding|DNA binding|damaged DNA binding|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|plasma membrane|DNA replication|postreplication repair|double-strand break repair|double-strand break repair via nonhomologous end joining|regulation of gene expression by genetic imprinting|regulation of transcription by RNA polymerase II|regulation of transcription by RNA polymerase III|fatty acid biosynthetic process|apoptotic process|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|chromosome segregation|centrosome cycle|zinc ion binding|gamma-tubulin ring complex|intrinsic apoptotic signaling pathway in response to DNA damage|dosage compensation by inactivation of X chromosome|response to ionizing radiation|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|tubulin binding|protein ubiquitination|protein deubiquitination|nuclear body|enzyme binding|positive regulation of protein ubiquitination|BRCA1-BARD1 complex|ubiquitin protein ligase binding|protein-containing complex|negative regulation of intracellular estrogen receptor signaling pathway|positive regulation of histone acetylation|negative regulation of histone acetylation|regulation of cell population proliferation|identical protein binding|regulation of apoptotic process|chordate embryonic development|response to estrogen|regulation of DNA methylation|mitotic G2/M transition checkpoint|negative regulation of fatty acid biosynthetic process|positive regulation of DNA repair|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of centriole replication|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|positive regulation of histone H3-K9 methylation|protein autoubiquitination|RNA polymerase binding|negative regulation of G0 to G1 transition|positive regulation of histone H4-K20 methylation|BRCA1-A complex|positive regulation of cell cycle arrest|cellular response to tumor necrosis factor|cellular response to indole-3-methanol|signal transduction involved in G2 DNA damage checkpoint|protein K6-linked ubiquitination|regulation of signal transduction by p53 class mediator|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|ribonucleoprotein complex|negative regulation of reactive oxygen species metabolic process|positive regulation of histone H3-K9 acetylation|positive regulation of histone H4-K16 acetylation" "hsa01524,hsa03440,hsa03460,hsa04120,hsa04151,hsa05206,hsa05224" Platinum drug resistance|Homologous recombination|Fanconi anemia pathway|Ubiquitin mediated proteolysis|PI3K-Akt signaling pathway|MicroRNAs in cancer|Breast cancer other BRCA2 468.2891025 491.2386887 445.3395163 0.906564419 -0.141518556 0.736855223 1 2.08127042 1.968081646 675 BRCA2 DNA repair associated "GO:0000722,GO:0000724,GO:0000781,GO:0000800,GO:0001556,GO:0001833,GO:0002020,GO:0003697,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006289,GO:0006302,GO:0006355,GO:0006978,GO:0007141,GO:0007283,GO:0007420,GO:0007569,GO:0008022,GO:0008585,GO:0010165,GO:0010225,GO:0010332,GO:0010484,GO:0010485,GO:0030097,GO:0030141,GO:0032465,GO:0032991,GO:0033593,GO:0033600,GO:0042771,GO:0042802,GO:0043015,GO:0043966,GO:0043967,GO:0045893,GO:0045931,GO:0048478,GO:0051298,GO:0070200,GO:1990426" "telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, telomeric region|lateral element|oocyte maturation|inner cell mass cell proliferation|protease binding|single-stranded DNA binding|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|centrosome|cytosol|nucleotide-excision repair|double-strand break repair|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|male meiosis I|spermatogenesis|brain development|cell aging|protein C-terminus binding|female gonad development|response to X-ray|response to UV-C|response to gamma radiation|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|hemopoiesis|secretory granule|regulation of cytokinesis|protein-containing complex|BRCA2-MAGE-D1 complex|negative regulation of mammary gland epithelial cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|gamma-tubulin binding|histone H3 acetylation|histone H4 acetylation|positive regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|replication fork protection|centrosome duplication|establishment of protein localization to telomere|mitotic recombination-dependent replication fork processing" "hsa03440,hsa03460,hsa05200,hsa05212,hsa05224" Homologous recombination|Fanconi anemia pathway|Pathways in cancer|Pancreatic cancer|Breast cancer BRCC3 660.6989712 679.0055428 642.3923996 0.946078285 -0.079968528 0.837768778 1 11.64946997 11.49606394 79184 BRCA1/BRCA2-containing complex subunit 3 "GO:0000151,GO:0000152,GO:0000922,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006302,GO:0006303,GO:0007049,GO:0008237,GO:0010165,GO:0010212,GO:0016579,GO:0018215,GO:0030234,GO:0031593,GO:0045739,GO:0046872,GO:0050790,GO:0051301,GO:0061578,GO:0070122,GO:0070531,GO:0070536,GO:0070537,GO:0070552,GO:0072425" ubiquitin ligase complex|nuclear ubiquitin ligase complex|spindle pole|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|cell cycle|metallopeptidase activity|response to X-ray|response to ionizing radiation|protein deubiquitination|protein phosphopantetheinylation|enzyme regulator activity|polyubiquitin modification-dependent protein binding|positive regulation of DNA repair|metal ion binding|regulation of catalytic activity|cell division|Lys63-specific deubiquitinase activity|isopeptidase activity|BRCA1-A complex|protein K63-linked deubiquitination|histone H2A K63-linked deubiquitination|BRISC complex|signal transduction involved in G2 DNA damage checkpoint "hsa03440,hsa04621" Homologous recombination|NOD-like receptor signaling pathway BRD1 1152.627739 1068.748635 1236.506843 1.156966945 0.210347647 0.541880182 1 4.432753094 5.349465888 23774 bromodomain containing 1 "GO:0005515,GO:0005634,GO:0005694,GO:0016607,GO:0030425,GO:0035902,GO:0036409,GO:0042393,GO:0043204,GO:0043249,GO:0043966,GO:0043972,GO:0043994,GO:0044154,GO:0045648,GO:0046872,GO:0051602,GO:0070776" protein binding|nucleus|chromosome|nuclear speck|dendrite|response to immobilization stress|histone H3-K14 acetyltransferase complex|histone binding|perikaryon|erythrocyte maturation|histone H3 acetylation|histone H3-K23 acetylation|histone acetyltransferase activity (H3-K23 specific)|histone H3-K14 acetylation|positive regulation of erythrocyte differentiation|metal ion binding|response to electrical stimulus|MOZ/MORF histone acetyltransferase complex BRD2 3292.246709 3299.621853 3284.871565 0.995529703 -0.006463733 0.984852519 1 30.56780803 31.74201185 6046 bromodomain containing 2 "GO:0001843,GO:0003682,GO:0004674,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006334,GO:0006357,GO:0006468,GO:0007283,GO:0016032,GO:0016607,GO:0070577" neural tube closure|chromatin binding|protein serine/threonine kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|nucleosome assembly|regulation of transcription by RNA polymerase II|protein phosphorylation|spermatogenesis|viral process|nuclear speck|lysine-acetylated histone binding other BRD3 1221.917412 1158.06476 1285.770064 1.110274752 0.150916734 0.659351912 1 9.27449315 10.74079873 8019 bromodomain containing 3 "GO:0003682,GO:0005515,GO:0005634,GO:0006325,GO:0006357,GO:0070577" chromatin binding|protein binding|nucleus|chromatin organization|regulation of transcription by RNA polymerase II|lysine-acetylated histone binding chromosome_remodelling_factor BRD3OS 1026.142749 1043.374735 1008.910763 0.966968749 -0.04845883 0.892773585 1 9.300114317 9.380298422 266655 BRD3 opposite strand BRD4 1927.505297 1841.130127 2013.880467 1.093828425 0.129386459 0.689685341 1 8.918866169 10.17594573 23476 bromodomain containing 4 "GO:0000083,GO:0000794,GO:0002039,GO:0003682,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006468,GO:0006974,GO:0008353,GO:0010971,GO:0016032,GO:0019899,GO:0032968,GO:0043123,GO:0045893,GO:0045944,GO:0050727,GO:0070577,GO:0099122,GO:0106140,GO:1901407,GO:2001255" "regulation of transcription involved in G1/S transition of mitotic cell cycle|condensed nuclear chromosome|p53 binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|chromatin organization|protein phosphorylation|cellular response to DNA damage stimulus|RNA polymerase II CTD heptapeptide repeat kinase activity|positive regulation of G2/M transition of mitotic cell cycle|viral process|enzyme binding|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of inflammatory response|lysine-acetylated histone binding|RNA polymerase II C-terminal domain binding|P-TEFb complex binding|regulation of phosphorylation of RNA polymerase II C-terminal domain|positive regulation of histone H3-K36 trimethylation" chromosome_remodelling_factor BRD7 1000.338322 963.193214 1037.483431 1.077129091 0.107191163 0.762949649 1 7.887201026 8.861486804 29117 bromodomain containing 7 "GO:0000976,GO:0002039,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007049,GO:0008134,GO:0008285,GO:0016055,GO:0035066,GO:0042393,GO:0045892,GO:0045893,GO:0070577,GO:1901796,GO:2000134" "transcription regulatory region sequence-specific DNA binding|p53 binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|cell cycle|transcription factor binding|negative regulation of cell population proliferation|Wnt signaling pathway|positive regulation of histone acetylation|histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|lysine-acetylated histone binding|regulation of signal transduction by p53 class mediator|negative regulation of G1/S transition of mitotic cell cycle" hsa05225 Hepatocellular carcinoma chromosome_remodelling_factor BRD8 1678.96381 1486.910494 1871.017127 1.258325323 0.33150496 0.311221118 1 16.38885114 21.51084034 10902 bromodomain containing 8 "GO:0000812,GO:0005515,GO:0005654,GO:0005739,GO:0007166,GO:0016573,GO:0030374,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0045944,GO:0046966,GO:0097067" Swr1 complex|protein binding|nucleoplasm|mitochondrion|cell surface receptor signaling pathway|histone acetylation|nuclear receptor coactivator activity|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|cellular response to thyroid hormone stimulus BRD9 1520.554967 1367.145689 1673.964244 1.22442272 0.29210172 0.377681604 1 9.255594996 11.82093017 65980 bromodomain containing 9 "GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006357,GO:0008150,GO:0016514,GO:0070577" nucleic acid binding|protein binding|nucleus|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|biological_process|SWI/SNF complex|lysine-acetylated histone binding BRF1 717.1977742 735.8430771 698.5524713 0.949322611 -0.075029649 0.844936265 1 6.320871091 6.259025029 2972 BRF1 RNA polymerase III transcription initiation factor subunit "GO:0000126,GO:0000995,GO:0001006,GO:0005515,GO:0005634,GO:0005654,GO:0006352,GO:0006383,GO:0006384,GO:0009303,GO:0009304,GO:0017025,GO:0045945,GO:0046872,GO:0070897,GO:0097550" "transcription factor TFIIIB complex|RNA polymerase III general transcription initiation factor activity|RNA polymerase III type 3 promoter sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|DNA-templated transcription, initiation|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|rRNA transcription|tRNA transcription|TBP-class protein binding|positive regulation of transcription by RNA polymerase III|metal ion binding|transcription preinitiation complex assembly|transcription preinitiation complex" other BRF2 243.6827125 257.798816 229.5666091 0.890487445 -0.167332823 0.746251947 1 5.100234597 4.737332673 55290 BRF2 RNA polymerase III transcription initiation factor subunit "GO:0000126,GO:0001006,GO:0005634,GO:0005654,GO:0006352,GO:0006359,GO:0017025,GO:0034599,GO:0046872,GO:0070897,GO:0097550" "transcription factor TFIIIB complex|RNA polymerase III type 3 promoter sequence-specific DNA binding|nucleus|nucleoplasm|DNA-templated transcription, initiation|regulation of transcription by RNA polymerase III|TBP-class protein binding|cellular response to oxidative stress|metal ion binding|transcription preinitiation complex assembly|transcription preinitiation complex" other BRI3 1539.949731 1514.314305 1565.585158 1.033857471 0.048037308 0.886245303 1 44.28099155 47.75226076 25798 brain protein I3 "GO:0005515,GO:0005634,GO:0005886,GO:0016021,GO:0035577,GO:0042802,GO:0043312,GO:0048471" protein binding|nucleus|plasma membrane|integral component of membrane|azurophil granule membrane|identical protein binding|neutrophil degranulation|perinuclear region of cytoplasm BRI3BP 852.1302565 968.2679938 735.9925192 0.760112411 -0.395715304 0.275594673 1 6.463603274 5.124699985 140707 BRI3 binding protein "GO:0005515,GO:0005739,GO:0005741,GO:0016021" protein binding|mitochondrion|mitochondrial outer membrane|integral component of membrane BRICD5 34.87024475 26.38885518 43.35163433 1.642800873 0.716157619 0.456069268 1 1.618041671 2.772621311 283870 BRICHOS domain containing 5 "GO:0005515,GO:0005615,GO:0016021,GO:0042127" protein binding|extracellular space|integral component of membrane|regulation of cell population proliferation BRINP2 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.021586201 0.007285787 57795 BMP/retinoic acid inducible neural specific 2 "GO:0005576,GO:0005783,GO:0007050,GO:0030425,GO:0043025,GO:0045666,GO:0045930,GO:0071300" extracellular region|endoplasmic reticulum|cell cycle arrest|dendrite|neuronal cell body|positive regulation of neuron differentiation|negative regulation of mitotic cell cycle|cellular response to retinoic acid BRIP1 1119.661959 936.8043588 1302.519559 1.390385886 0.475485343 0.16935844 1 3.99006273 5.786700481 83990 BRCA1 interacting protein C-terminal helicase 1 "GO:0000077,GO:0003677,GO:0003678,GO:0003682,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006289,GO:0006302,GO:0006357,GO:0007284,GO:0007286,GO:0008285,GO:0009636,GO:0010629,GO:0010705,GO:0031965,GO:0032508,GO:0046872,GO:0051026,GO:0051539,GO:0071295,GO:0071456,GO:0072520,GO:1901796,GO:1904385,GO:1990918" "DNA damage checkpoint|DNA binding|DNA helicase activity|chromatin binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|DNA replication|nucleotide-excision repair|double-strand break repair|regulation of transcription by RNA polymerase II|spermatogonial cell division|spermatid development|negative regulation of cell population proliferation|response to toxic substance|negative regulation of gene expression|meiotic DNA double-strand break processing involved in reciprocal meiotic recombination|nuclear membrane|DNA duplex unwinding|metal ion binding|chiasma assembly|4 iron, 4 sulfur cluster binding|cellular response to vitamin|cellular response to hypoxia|seminiferous tubule development|regulation of signal transduction by p53 class mediator|cellular response to angiotensin|double-strand break repair involved in meiotic recombination" "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway BRIX1 631.7227456 685.0952787 578.3502125 0.844189459 -0.24436128 0.52831855 1 21.80871087 19.20374142 55299 biogenesis of ribosomes BRX1 "GO:0000027,GO:0003723,GO:0005515,GO:0005694,GO:0005730" ribosomal large subunit assembly|RNA binding|protein binding|chromosome|nucleolus BRK1 3431.784349 3442.730645 3420.838054 0.993640923 -0.009203503 0.977926064 1 151.6192712 157.1447238 55845 BRICK1 subunit of SCAR/WAVE actin nucleating complex "GO:0001701,GO:0005515,GO:0005829,GO:0005856,GO:0007015,GO:0008064,GO:0008284,GO:0010592,GO:0016601,GO:0030027,GO:0031209,GO:0031267,GO:0031334,GO:0038096,GO:0042802,GO:0044877,GO:0048010,GO:0048870,GO:0070062,GO:2000601" in utero embryonic development|protein binding|cytosol|cytoskeleton|actin filament organization|regulation of actin polymerization or depolymerization|positive regulation of cell population proliferation|positive regulation of lamellipodium assembly|Rac protein signal transduction|lamellipodium|SCAR complex|small GTPase binding|positive regulation of protein-containing complex assembly|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|protein-containing complex binding|vascular endothelial growth factor receptor signaling pathway|cell motility|extracellular exosome|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04810,hsa05130,hsa05132" Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection BRME1 60.39532332 53.79266632 66.99798033 1.245485396 0.316708105 0.704777459 1 0.498337073 0.64740756 79173 break repair meiotic recombinase recruitment factor 1 "GO:0003674,GO:0005515,GO:0005575,GO:0005694,GO:0007275,GO:0007283,GO:1990918" molecular_function|protein binding|cellular_component|chromosome|multicellular organism development|spermatogenesis|double-strand break repair involved in meiotic recombination BRMS1 742.3732351 840.3835418 644.3629284 0.766748629 -0.383174413 0.304518855 1 29.76395923 23.80453151 25855 BRMS1 transcriptional repressor and anoikis regulator "GO:0000122,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006915,GO:0016575,GO:0032088,GO:0042826,GO:0042981,GO:0045892,GO:0051059,GO:0070822,GO:0090312,GO:2000210" "negative regulation of transcription by RNA polymerase II|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|apoptotic process|histone deacetylation|negative regulation of NF-kappaB transcription factor activity|histone deacetylase binding|regulation of apoptotic process|negative regulation of transcription, DNA-templated|NF-kappaB binding|Sin3-type complex|positive regulation of protein deacetylation|positive regulation of anoikis" BRMS1L 331.12827 308.5466144 353.7099255 1.146374353 0.197078239 0.671082102 1 4.136261919 4.945957986 84312 BRMS1 like transcriptional repressor "GO:0000122,GO:0004407,GO:0005515,GO:0016575,GO:0040008,GO:0042826,GO:0070822" negative regulation of transcription by RNA polymerase II|histone deacetylase activity|protein binding|histone deacetylation|regulation of growth|histone deacetylase binding|Sin3-type complex BROX 1342.740472 1234.186458 1451.294486 1.175911854 0.23377992 0.487600993 1 13.12900444 16.10358216 148362 BRO1 domain and CAAX motif containing "GO:0005515,GO:0016020,GO:0070062" protein binding|membrane|extracellular exosome BRPF1 1030.846384 1028.150396 1033.542373 1.005244347 0.007546223 0.985941991 1 10.32154419 10.8226159 7862 bromodomain and PHD finger containing 1 "GO:0000123,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0005886,GO:0010698,GO:0042393,GO:0043966,GO:0043972,GO:0043994,GO:0044154,GO:0045893,GO:0046872,GO:0050790,GO:0070776,GO:1901796" "histone acetyltransferase complex|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|plasma membrane|acetyltransferase activator activity|histone binding|histone H3 acetylation|histone H3-K23 acetylation|histone acetyltransferase activity (H3-K23 specific)|histone H3-K14 acetylation|positive regulation of transcription, DNA-templated|metal ion binding|regulation of catalytic activity|MOZ/MORF histone acetyltransferase complex|regulation of signal transduction by p53 class mediator" BRPF3 1495.988182 1304.218419 1687.757946 1.294076146 0.371922511 0.262234423 1 9.605069352 12.96511181 27154 bromodomain and PHD finger containing 3 "GO:0000123,GO:0002576,GO:0005515,GO:0005576,GO:0005829,GO:0042393,GO:0043966,GO:0043972,GO:0043994,GO:0044154,GO:0045740,GO:0046872,GO:0070776" histone acetyltransferase complex|platelet degranulation|protein binding|extracellular region|cytosol|histone binding|histone H3 acetylation|histone H3-K23 acetylation|histone acetyltransferase activity (H3-K23 specific)|histone H3-K14 acetylation|positive regulation of DNA replication|metal ion binding|MOZ/MORF histone acetyltransferase complex BRSK1 233.3131878 188.7818101 277.8445655 1.471776149 0.55755826 0.277421547 1 2.818730159 4.327242089 84446 BR serine/threonine kinase 1 "GO:0000086,GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006468,GO:0006974,GO:0007095,GO:0007269,GO:0007409,GO:0008021,GO:0008306,GO:0009411,GO:0010212,GO:0010975,GO:0018105,GO:0019901,GO:0030010,GO:0030054,GO:0030182,GO:0035556,GO:0042149,GO:0043015,GO:0048156,GO:0048167,GO:0048786,GO:0050321,GO:0050770,GO:0051298,GO:0090176,GO:0099504,GO:0106310,GO:0106311,GO:0150034,GO:2000807" G2/M transition of mitotic cell cycle|magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|protein phosphorylation|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|neurotransmitter secretion|axonogenesis|synaptic vesicle|associative learning|response to UV|response to ionizing radiation|regulation of neuron projection development|peptidyl-serine phosphorylation|protein kinase binding|establishment of cell polarity|cell junction|neuron differentiation|intracellular signal transduction|cellular response to glucose starvation|gamma-tubulin binding|tau protein binding|regulation of synaptic plasticity|presynaptic active zone|tau-protein kinase activity|regulation of axonogenesis|centrosome duplication|microtubule cytoskeleton organization involved in establishment of planar polarity|synaptic vesicle cycle|protein serine kinase activity|protein threonine kinase activity|distal axon|regulation of synaptic vesicle clustering BRSK2 285.4673756 251.7090802 319.225671 1.268232639 0.342819411 0.477323873 1 2.098465339 2.775982064 9024 BR serine/threonine kinase 2 "GO:0000086,GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005783,GO:0005813,GO:0006468,GO:0006887,GO:0007409,GO:0010975,GO:0018105,GO:0019901,GO:0030010,GO:0030182,GO:0031532,GO:0035556,GO:0036503,GO:0042149,GO:0043462,GO:0048156,GO:0048471,GO:0050321,GO:0050770,GO:0051117,GO:0051301,GO:0060590,GO:0061178,GO:0070059,GO:0090176,GO:0106310,GO:0106311,GO:0150034,GO:1904152,GO:2000807" "G2/M transition of mitotic cell cycle|magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|endoplasmic reticulum|centrosome|protein phosphorylation|exocytosis|axonogenesis|regulation of neuron projection development|peptidyl-serine phosphorylation|protein kinase binding|establishment of cell polarity|neuron differentiation|actin cytoskeleton reorganization|intracellular signal transduction|ERAD pathway|cellular response to glucose starvation|regulation of ATPase activity|tau protein binding|perinuclear region of cytoplasm|tau-protein kinase activity|regulation of axonogenesis|ATPase binding|cell division|ATPase regulator activity|regulation of insulin secretion involved in cellular response to glucose stimulus|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|microtubule cytoskeleton organization involved in establishment of planar polarity|protein serine kinase activity|protein threonine kinase activity|distal axon|regulation of retrograde protein transport, ER to cytosol|regulation of synaptic vesicle clustering" BRWD1 1481.851544 1482.85067 1480.852418 0.998652426 -0.00194545 0.997655606 1 3.186167547 3.318936174 54014 bromodomain and WD repeat domain containing 1 "GO:0003674,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006325,GO:0006357,GO:0007010,GO:0008360,GO:0038111" molecular_function|nucleus|nucleoplasm|nucleolus|cytosol|chromatin organization|regulation of transcription by RNA polymerase II|cytoskeleton organization|regulation of cell shape|interleukin-7-mediated signaling pathway BRWD3 1084.601194 1234.186458 935.0159313 0.757596979 -0.400497518 0.249360207 1 4.844016594 3.827892968 254065 bromodomain and WD repeat domain containing 3 "GO:0005634,GO:0006357,GO:0007010,GO:0008360" nucleus|regulation of transcription by RNA polymerase II|cytoskeleton organization|regulation of cell shape BSCL2 816.2477774 906.3556798 726.139875 0.801164368 -0.319829837 0.382439143 1 20.61235642 17.22523671 26580 "BSCL2 lipid droplet biogenesis associated, seipin" "GO:0005515,GO:0005543,GO:0005789,GO:0005811,GO:0016042,GO:0019915,GO:0030176,GO:0034389,GO:0045444,GO:0050995,GO:0120162,GO:0140042" protein binding|phospholipid binding|endoplasmic reticulum membrane|lipid droplet|lipid catabolic process|lipid storage|integral component of endoplasmic reticulum membrane|lipid droplet organization|fat cell differentiation|negative regulation of lipid catabolic process|positive regulation of cold-induced thermogenesis|lipid droplet formation BSDC1 1430.31296 1192.573263 1668.052657 1.398700364 0.484086935 0.146982695 1 11.84074272 17.27505992 55108 BSD domain containing 1 GO:0005515 protein binding BSG 8816.015638 9320.340658 8311.690618 0.891779702 -0.165240732 0.619822009 1 208.4992819 193.9447717 682 basigin (Ok blood group) "GO:0000139,GO:0001525,GO:0001618,GO:0001750,GO:0001917,GO:0002080,GO:0005515,GO:0005537,GO:0005739,GO:0005768,GO:0005789,GO:0005886,GO:0005887,GO:0005925,GO:0006090,GO:0007156,GO:0007166,GO:0007411,GO:0007566,GO:0016020,GO:0016323,GO:0022617,GO:0030198,GO:0030424,GO:0030593,GO:0042383,GO:0042470,GO:0042475,GO:0043231,GO:0043434,GO:0045121,GO:0045296,GO:0046689,GO:0046697,GO:0046718,GO:0050900,GO:0051591,GO:0070062,GO:0070593,GO:0072659,GO:0098632" Golgi membrane|angiogenesis|virus receptor activity|photoreceptor outer segment|photoreceptor inner segment|acrosomal membrane|protein binding|mannose binding|mitochondrion|endosome|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|focal adhesion|pyruvate metabolic process|homophilic cell adhesion via plasma membrane adhesion molecules|cell surface receptor signaling pathway|axon guidance|embryo implantation|membrane|basolateral plasma membrane|extracellular matrix disassembly|extracellular matrix organization|axon|neutrophil chemotaxis|sarcolemma|melanosome|odontogenesis of dentin-containing tooth|intracellular membrane-bounded organelle|response to peptide hormone|membrane raft|cadherin binding|response to mercury ion|decidualization|viral entry into host cell|leukocyte migration|response to cAMP|extracellular exosome|dendrite self-avoidance|protein localization to plasma membrane|cell-cell adhesion mediator activity BSN 33.43688546 29.43372308 37.44004783 1.272011961 0.347112237 0.737997803 1 0.093338816 0.123842416 8927 bassoon presynaptic cytomatrix protein "GO:0005634,GO:0007268,GO:0008021,GO:0009986,GO:0014069,GO:0030424,GO:0030425,GO:0030672,GO:0035418,GO:0044306,GO:0046872,GO:0048786,GO:0048788,GO:0048790,GO:0060076,GO:0098685,GO:0098693,GO:0098882,GO:0098978,GO:0098982,GO:0099526,GO:1904071" nucleus|chemical synaptic transmission|synaptic vesicle|cell surface|postsynaptic density|axon|dendrite|synaptic vesicle membrane|protein localization to synapse|neuron projection terminus|metal ion binding|presynaptic active zone|cytoskeleton of presynaptic active zone|maintenance of presynaptic active zone structure|excitatory synapse|Schaffer collateral - CA1 synapse|regulation of synaptic vesicle cycle|structural constituent of presynaptic active zone|glutamatergic synapse|GABA-ergic synapse|presynapse to nucleus signaling pathway|presynaptic active zone assembly BSPRY 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.04416146 0.067074309 54836 B-box and SPRY domain containing "GO:0005737,GO:0006816,GO:0008270,GO:0016020,GO:0016567,GO:0031252,GO:0048471,GO:0061630,GO:1990830" cytoplasm|calcium ion transport|zinc ion binding|membrane|protein ubiquitination|cell leading edge|perinuclear region of cytoplasm|ubiquitin protein ligase activity|cellular response to leukemia inhibitory factor BST1 3.47811701 2.029911937 4.926322083 2.426864926 1.279093814 0.644064692 1 0.019427037 0.049177687 683 bone marrow stromal cell antigen 1 "GO:0001931,GO:0001952,GO:0002691,GO:0003953,GO:0005576,GO:0005886,GO:0006959,GO:0007165,GO:0008284,GO:0016740,GO:0016849,GO:0019674,GO:0019898,GO:0030890,GO:0031225,GO:0032956,GO:0035579,GO:0043312,GO:0050135,GO:0050727,GO:0050730,GO:0050848,GO:0061809,GO:0061811,GO:0061812,GO:0070062,GO:0090022,GO:0090322,GO:2001044" "uropod|regulation of cell-matrix adhesion|regulation of cellular extravasation|NAD+ nucleosidase activity|extracellular region|plasma membrane|humoral immune response|signal transduction|positive regulation of cell population proliferation|transferase activity|phosphorus-oxygen lyase activity|NAD metabolic process|extrinsic component of membrane|positive regulation of B cell proliferation|anchored component of membrane|regulation of actin cytoskeleton organization|specific granule membrane|neutrophil degranulation|NAD(P)+ nucleosidase activity|regulation of inflammatory response|regulation of peptidyl-tyrosine phosphorylation|regulation of calcium-mediated signaling|NAD+ nucleotidase, cyclic ADP-ribose generating|ADP-ribosyl cyclase activity|cyclic ADP-ribose hydrolase|extracellular exosome|regulation of neutrophil chemotaxis|regulation of superoxide metabolic process|regulation of integrin-mediated signaling pathway" "hsa00760,hsa04970,hsa04972" Nicotinate and nicotinamide metabolism|Salivary secretion|Pancreatic secretion BST2 2889.522228 2811.428032 2967.616423 1.055554824 0.078001512 0.807173804 1 142.2466651 156.6169701 684 bone marrow stromal cell antigen 2 "GO:0002737,GO:0003723,GO:0005515,GO:0005737,GO:0005771,GO:0005794,GO:0005829,GO:0005886,GO:0008191,GO:0009615,GO:0009986,GO:0010951,GO:0016020,GO:0016021,GO:0016324,GO:0030308,GO:0030336,GO:0031225,GO:0032956,GO:0034341,GO:0035455,GO:0035456,GO:0035577,GO:0042113,GO:0042802,GO:0042803,GO:0043123,GO:0043312,GO:0045071,GO:0045087,GO:0045121,GO:0051607,GO:0060337,GO:0070062,GO:0070665,GO:1901253" negative regulation of plasmacytoid dendritic cell cytokine production|RNA binding|protein binding|cytoplasm|multivesicular body|Golgi apparatus|cytosol|plasma membrane|metalloendopeptidase inhibitor activity|response to virus|cell surface|negative regulation of endopeptidase activity|membrane|integral component of membrane|apical plasma membrane|negative regulation of cell growth|negative regulation of cell migration|anchored component of membrane|regulation of actin cytoskeleton organization|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|azurophil granule membrane|B cell activation|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|negative regulation of viral genome replication|innate immune response|membrane raft|defense response to virus|type I interferon signaling pathway|extracellular exosome|positive regulation of leukocyte proliferation|negative regulation of intracellular transport of viral material "hsa05168,hsa05170" Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection BTAF1 5595.056593 5404.640532 5785.472654 1.070463913 0.098236162 0.761331515 1 33.07467092 36.93035588 9044 B-TFIID TATA-box binding protein associated factor 1 "GO:0003677,GO:0003712,GO:0004386,GO:0005524,GO:0005654,GO:0008094,GO:0035562,GO:0043231,GO:0045892" "DNA binding|transcription coregulator activity|helicase activity|ATP binding|nucleoplasm|DNA-dependent ATPase activity|negative regulation of chromatin binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated" other BTBD1 2302.772027 2203.469407 2402.074648 1.090132969 0.124504119 0.697743396 1 34.93987229 39.72983097 53339 BTB domain containing 1 "GO:0000932,GO:0005515,GO:0005654,GO:0005829,GO:0007517,GO:0016567,GO:0022008,GO:0032991,GO:0036464,GO:0042802,GO:0043393,GO:0043687,GO:0097602" P-body|protein binding|nucleoplasm|cytosol|muscle organ development|protein ubiquitination|neurogenesis|protein-containing complex|cytoplasmic ribonucleoprotein granule|identical protein binding|regulation of protein binding|post-translational protein modification|cullin family protein binding BTBD10 1087.130666 969.2829498 1204.978381 1.243164735 0.314017484 0.366398238 1 16.83496639 21.83015731 84280 BTB domain containing 10 "GO:0001650,GO:0005515,GO:0005654,GO:0005737,GO:0042327,GO:0044342,GO:1901215" fibrillar center|protein binding|nucleoplasm|cytoplasm|positive regulation of phosphorylation|type B pancreatic cell proliferation|negative regulation of neuron death BTBD11 275.5889992 384.668312 166.5096864 0.432865617 -1.208008883 0.013744751 0.521881214 2.239321032 1.011079674 121551 BTB domain containing 11 "GO:0016021,GO:0046982,GO:0060395" integral component of membrane|protein heterodimerization activity|SMAD protein signal transduction BTBD19 111.502142 146.1536594 76.85062449 0.525820734 -0.927357064 0.15702885 1 1.792726387 0.98325836 149478 BTB domain containing 19 BTBD2 1663.392329 1870.56385 1456.220808 0.77849297 -0.361244083 0.27025778 1 35.23148384 28.60892635 55643 BTB domain containing 2 "GO:0000932,GO:0005515,GO:0005829,GO:0022008" P-body|protein binding|cytosol|neurogenesis BTBD3 704.9913326 675.9606749 734.0219903 1.085894517 0.118883967 0.755201922 1 6.659214849 7.542695869 22903 BTB domain containing 3 "GO:0005515,GO:0005634,GO:0005829,GO:0021987,GO:0022008,GO:0042802,GO:0048813" protein binding|nucleus|cytosol|cerebral cortex development|neurogenesis|identical protein binding|dendrite morphogenesis BTBD6 1402.541964 1247.380885 1557.703043 1.248778991 0.320518171 0.338019961 1 31.65102271 41.22771459 90135 BTB domain containing 6 "GO:0005829,GO:0022008,GO:0043687" cytosol|neurogenesis|post-translational protein modification BTBD7 1240.988291 1249.410797 1232.565785 0.986517635 -0.019583254 0.956641487 1 6.616987265 6.808964687 55727 BTB domain containing 7 "GO:0005634,GO:0007275,GO:0060693,GO:0061138" nucleus|multicellular organism development|regulation of branching involved in salivary gland morphogenesis|morphogenesis of a branching epithelium BTBD8 145.2116946 126.869496 163.5538931 1.289150649 0.366420865 0.544729588 1 1.038715229 1.396741703 284697 BTB domain containing 8 "GO:0005654,GO:0008021,GO:0030122,GO:0030424,GO:0031175,GO:0036466,GO:0044297,GO:0044306,GO:0098793,GO:0150007" nucleoplasm|synaptic vesicle|AP-2 adaptor complex|axon|neuron projection development|synaptic vesicle recycling via endosome|cell body|neuron projection terminus|presynapse|clathrin-dependent synaptic vesicle endocytosis BTBD9 308.6723076 356.2495449 261.0950704 0.732899379 -0.448312952 0.339444003 1 1.45611998 1.113159622 114781 BTB domain containing 9 "GO:0007616,GO:0008344,GO:0042428,GO:0042748,GO:0048512,GO:0050804,GO:0050951,GO:0060586,GO:1900242" "long-term memory|adult locomotory behavior|serotonin metabolic process|circadian sleep/wake cycle, non-REM sleep|circadian behavior|modulation of chemical synaptic transmission|sensory perception of temperature stimulus|multicellular organismal iron ion homeostasis|regulation of synaptic vesicle endocytosis" BTC 38.8855313 31.46363502 46.30742758 1.471776149 0.55755826 0.552889812 1 0.372231282 0.571439896 685 betacellulin "GO:0000165,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007165,GO:0007173,GO:0008083,GO:0008284,GO:0016021,GO:0030665,GO:0035810,GO:0038128,GO:0042059,GO:0043066,GO:0045597,GO:0045741,GO:0045840,GO:0048146,GO:0051781,GO:0051897,GO:0061024,GO:2000145" MAPK cascade|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|plasma membrane|signal transduction|epidermal growth factor receptor signaling pathway|growth factor activity|positive regulation of cell population proliferation|integral component of membrane|clathrin-coated vesicle membrane|positive regulation of urine volume|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of apoptotic process|positive regulation of cell differentiation|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitotic nuclear division|positive regulation of fibroblast proliferation|positive regulation of cell division|positive regulation of protein kinase B signaling|membrane organization|regulation of cell motility hsa04012 ErbB signaling pathway BTD 1288.454927 1497.060053 1079.849801 0.721313616 -0.471301437 0.163937585 1 5.307722113 3.993449872 686 biotinidase "GO:0005576,GO:0005615,GO:0005759,GO:0006768,GO:0007417,GO:0047708,GO:0070062" extracellular region|extracellular space|mitochondrial matrix|biotin metabolic process|central nervous system development|biotinidase activity|extracellular exosome "hsa00780,hsa04977" Biotin metabolism|Vitamin digestion and absorption BTF3 10185.22884 10309.92273 10060.53496 0.975810898 -0.035326499 0.916765414 1 504.5035893 513.5063924 689 basic transcription factor 3 "GO:0001701,GO:0003723,GO:0005515,GO:0005634,GO:0005829,GO:0005854,GO:0006366,GO:0015031,GO:0042788" in utero embryonic development|RNA binding|protein binding|nucleus|cytosol|nascent polypeptide-associated complex|transcription by RNA polymerase II|protein transport|polysomal ribosome BTF3L4 905.6816771 554.1659587 1257.197396 2.268629777 1.181821192 0.001121749 0.09746273 6.191606183 14.65152678 91408 basic transcription factor 3 like 4 GO:0005515 protein binding BTG1 2966.666308 3976.597484 1956.735131 0.492062659 -1.023086056 0.001436693 0.114546684 43.50845409 22.33109357 694 BTG anti-proliferation factor 1 "GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0008285,GO:0016477,GO:0019899,GO:0019900,GO:0030308,GO:0045603,GO:0045663,GO:0045766,GO:0045930,GO:2000271" "transcription coregulator activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|negative regulation of cell population proliferation|cell migration|enzyme binding|kinase binding|negative regulation of cell growth|positive regulation of endothelial cell differentiation|positive regulation of myoblast differentiation|positive regulation of angiogenesis|negative regulation of mitotic cell cycle|positive regulation of fibroblast apoptotic process" hsa03018 RNA degradation BTG2 29.39190736 22.3290313 36.45478341 1.632618223 0.707187466 0.486434112 1 0.414395992 0.705693498 7832 BTG anti-proliferation factor 2 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006281,GO:0006479,GO:0006974,GO:0006977,GO:0008285,GO:0008306,GO:0009612,GO:0009952,GO:0014070,GO:0017148,GO:0021542,GO:0021954,GO:0031175,GO:0035914,GO:0043434,GO:0043524,GO:0045930,GO:0051602,GO:0060213,GO:0070062,GO:2000178" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|cytoplasm|cytosol|DNA repair|protein methylation|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell population proliferation|associative learning|response to mechanical stimulus|anterior/posterior pattern specification|response to organic cyclic compound|negative regulation of translation|dentate gyrus development|central nervous system neuron development|neuron projection development|skeletal muscle cell differentiation|response to peptide hormone|negative regulation of neuron apoptotic process|negative regulation of mitotic cell cycle|response to electrical stimulus|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|extracellular exosome|negative regulation of neural precursor cell proliferation" hsa03018 RNA degradation BTG3 429.9070898 325.8008658 534.0133138 1.639078866 0.712885273 0.09404822 1 7.246668642 12.38951152 10950 BTG anti-proliferation factor 3 "GO:0005515,GO:0005634,GO:0005737,GO:0008285,GO:0045930" protein binding|nucleus|cytoplasm|negative regulation of cell population proliferation|negative regulation of mitotic cell cycle hsa03018 RNA degradation BTN2A1 891.4841717 930.714623 852.2537203 0.915698216 -0.127055882 0.725915705 1 13.02138461 12.43728152 11120 butyrophilin subfamily 2 member A1 "GO:0001817,GO:0003674,GO:0005102,GO:0005886,GO:0005887,GO:0006629,GO:0009897,GO:0050852" regulation of cytokine production|molecular_function|signaling receptor binding|plasma membrane|integral component of plasma membrane|lipid metabolic process|external side of plasma membrane|T cell receptor signaling pathway BTN2A2 226.0721624 198.9313698 253.2129551 1.27286589 0.348080424 0.504108052 1 2.429508583 3.225648318 10385 butyrophilin subfamily 2 member A2 "GO:0001817,GO:0001818,GO:0005102,GO:0005515,GO:0005886,GO:0009897,GO:0016021,GO:0031324,GO:0046007,GO:0050852" regulation of cytokine production|negative regulation of cytokine production|signaling receptor binding|protein binding|plasma membrane|external side of plasma membrane|integral component of membrane|negative regulation of cellular metabolic process|negative regulation of activated T cell proliferation|T cell receptor signaling pathway BTN3A1 122.1173639 130.9293199 113.3054079 0.865393695 -0.208571486 0.751355962 1 1.597472456 1.441992611 11119 butyrophilin subfamily 3 member A1 "GO:0001816,GO:0001817,GO:0002250,GO:0005102,GO:0005515,GO:0005886,GO:0009897,GO:0016021,GO:0032609,GO:0050798,GO:0050852" cytokine production|regulation of cytokine production|adaptive immune response|signaling receptor binding|protein binding|plasma membrane|external side of plasma membrane|integral component of membrane|interferon-gamma production|activated T cell proliferation|T cell receptor signaling pathway BTN3A2 232.530321 269.9782876 195.0823545 0.722585346 -0.468760097 0.362050062 1 3.750259967 2.826613663 11118 butyrophilin subfamily 3 member A2 "GO:0001817,GO:0002456,GO:0005102,GO:0005515,GO:0005886,GO:0009897,GO:0016020,GO:0016021,GO:0032609,GO:0050852" regulation of cytokine production|T cell mediated immunity|signaling receptor binding|protein binding|plasma membrane|external side of plasma membrane|membrane|integral component of membrane|interferon-gamma production|T cell receptor signaling pathway BTN3A3 169.689404 183.7070303 155.6717778 0.84739151 -0.23889942 0.680435176 1 3.132697981 2.768972009 10384 butyrophilin subfamily 3 member A3 "GO:0001817,GO:0002456,GO:0005102,GO:0005886,GO:0009897,GO:0016020,GO:0016021,GO:0050852" regulation of cytokine production|T cell mediated immunity|signaling receptor binding|plasma membrane|external side of plasma membrane|membrane|integral component of membrane|T cell receptor signaling pathway BTNL9 119.8323522 143.1087915 96.55591282 0.674702873 -0.56767579 0.375600391 1 1.410108061 0.992386584 153579 butyrophilin like 9 "GO:0001817,GO:0005102,GO:0005886,GO:0009897,GO:0016021,GO:0050852" regulation of cytokine production|signaling receptor binding|plasma membrane|external side of plasma membrane|integral component of membrane|T cell receptor signaling pathway BTRC 1622.593176 1506.194657 1738.991695 1.154559729 0.20734281 0.528376995 1 11.25788752 13.55780054 8945 beta-transducin repeat containing E3 ubiquitin protein ligase "GO:0000086,GO:0000209,GO:0002223,GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0006470,GO:0006511,GO:0007165,GO:0008013,GO:0016032,GO:0016055,GO:0016567,GO:0016874,GO:0019005,GO:0031146,GO:0031648,GO:0033598,GO:0038061,GO:0038095,GO:0042752,GO:0042753,GO:0043122,GO:0043161,GO:0043433,GO:0043687,GO:0045309,GO:0045862,GO:0045879,GO:0045892,GO:0045893,GO:0046983,GO:0048511,GO:0050852,GO:0051403,GO:0060444,GO:0060828,GO:0061136,GO:0061630,GO:0070498,GO:0070936,GO:0071407,GO:1901990,GO:1904668,GO:1990756,GO:1990757" "G2/M transition of mitotic cell cycle|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|protein dephosphorylation|ubiquitin-dependent protein catabolic process|signal transduction|beta-catenin binding|viral process|Wnt signaling pathway|protein ubiquitination|ligase activity|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein destabilization|mammary gland epithelial cell proliferation|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|regulation of circadian rhythm|positive regulation of circadian rhythm|regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA-binding transcription factor activity|post-translational protein modification|protein phosphorylated amino acid binding|positive regulation of proteolysis|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|rhythmic process|T cell receptor signaling pathway|stress-activated MAPK cascade|branching involved in mammary gland duct morphogenesis|regulation of canonical Wnt signaling pathway|regulation of proteasomal protein catabolic process|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway|protein K48-linked ubiquitination|cellular response to organic cyclic compound|regulation of mitotic cell cycle phase transition|positive regulation of ubiquitin protein ligase activity|ubiquitin ligase-substrate adaptor activity|ubiquitin ligase activator activity" "hsa04114,hsa04120,hsa04218,hsa04310,hsa04340,hsa04390,hsa04710,hsa05131,hsa05170" Oocyte meiosis|Ubiquitin mediated proteolysis|Cellular senescence|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Circadian rhythm|Shigellosis|Human immunodeficiency virus 1 infection BUB1 1801.57925 1550.85272 2052.30578 1.32334022 0.404184015 0.213823655 1 20.87858032 28.81963038 699 BUB1 mitotic checkpoint serine/threonine kinase "GO:0000776,GO:0000777,GO:0000778,GO:0000942,GO:0004672,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0006915,GO:0007063,GO:0007093,GO:0007094,GO:0008283,GO:0016020,GO:0016032,GO:0043231,GO:0051301,GO:0051754,GO:0051983,GO:0106310,GO:0106311" "kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome kinetochore|condensed nuclear chromosome outer kinetochore|protein kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|apoptotic process|regulation of sister chromatid cohesion|mitotic cell cycle checkpoint|mitotic spindle assembly checkpoint|cell population proliferation|membrane|viral process|intracellular membrane-bounded organelle|cell division|meiotic sister chromatid cohesion, centromeric|regulation of chromosome segregation|protein serine kinase activity|protein threonine kinase activity" "hsa04110,hsa04114,hsa04914" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation BUB1B 1549.710579 1541.718116 1557.703043 1.010368255 0.014881217 0.966178271 1 21.2817072 22.42859589 701 BUB1 mitotic checkpoint serine/threonine kinase B "GO:0000278,GO:0000776,GO:0000777,GO:0000778,GO:0000940,GO:0004672,GO:0005515,GO:0005524,GO:0005680,GO:0005737,GO:0005815,GO:0005819,GO:0005829,GO:0006468,GO:0006511,GO:0006915,GO:0007091,GO:0007093,GO:0007094,GO:0031145,GO:0048471,GO:0051301,GO:0051754,GO:0071459,GO:0106310,GO:0106311,GO:1901990" "mitotic cell cycle|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome kinetochore|condensed chromosome outer kinetochore|protein kinase activity|protein binding|ATP binding|anaphase-promoting complex|cytoplasm|microtubule organizing center|spindle|cytosol|protein phosphorylation|ubiquitin-dependent protein catabolic process|apoptotic process|metaphase/anaphase transition of mitotic cell cycle|mitotic cell cycle checkpoint|mitotic spindle assembly checkpoint|anaphase-promoting complex-dependent catabolic process|perinuclear region of cytoplasm|cell division|meiotic sister chromatid cohesion, centromeric|protein localization to chromosome, centromeric region|protein serine kinase activity|protein threonine kinase activity|regulation of mitotic cell cycle phase transition" "hsa04110,hsa05166" Cell cycle|Human T-cell leukemia virus 1 infection BUB1B-PAK6 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.03975556 0.01341832 106821730 BUB1B-PAK6 readthrough "hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05170,hsa05211" ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection|Renal cell carcinoma BUB3 3303.611147 3066.18198 3541.040313 1.154869586 0.207729944 0.513858621 1 20.15984687 24.28488788 9184 BUB3 mitotic checkpoint protein "GO:0000070,GO:0000776,GO:0000777,GO:0005515,GO:0005654,GO:0005829,GO:0006511,GO:0007094,GO:0008608,GO:0031145,GO:0033597,GO:0034501,GO:0043130,GO:0051301,GO:0051321,GO:1901990,GO:1990298" mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|protein binding|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|mitotic spindle assembly checkpoint|attachment of spindle microtubules to kinetochore|anaphase-promoting complex-dependent catabolic process|mitotic checkpoint complex|protein localization to kinetochore|ubiquitin binding|cell division|meiotic cell cycle|regulation of mitotic cell cycle phase transition|bub1-bub3 complex "hsa04110,hsa05166" Cell cycle|Human T-cell leukemia virus 1 infection BUD13 526.9002111 456.7301858 597.0702364 1.30727124 0.386558511 0.338286256 1 7.851925547 10.70675363 84811 BUD13 homolog "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005684,GO:0070274,GO:0071005" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U2-type spliceosomal complex|RES complex|U2-type precatalytic spliceosome" BUD23 1081.418755 1083.972974 1078.864536 0.995287301 -0.006815058 0.987364275 1 42.95728256 44.59654285 114049 BUD23 rRNA methyltransferase and ribosome maturation factor "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006325,GO:0008168,GO:0016435,GO:0031167,GO:0046982,GO:0048471,GO:0070476,GO:2000234" RNA binding|protein binding|nucleoplasm|nucleolus|chromatin organization|methyltransferase activity|rRNA (guanine) methyltransferase activity|rRNA methylation|protein heterodimerization activity|perinuclear region of cytoplasm|rRNA (guanine-N7)-methylation|positive regulation of rRNA processing BUD31 1094.34868 1058.599075 1130.098286 1.06754135 0.094291952 0.787834744 1 17.06375195 19.00094343 8896 BUD31 homolog "GO:0000398,GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0030374,GO:0035257,GO:0045893,GO:0071007,GO:2000825" "mRNA splicing, via spliceosome|chromatin|protein binding|nucleus|nucleoplasm|spliceosomal complex|nuclear receptor coactivator activity|nuclear hormone receptor binding|positive regulation of transcription, DNA-templated|U2-type catalytic step 2 spliceosome|positive regulation of androgen receptor activity" hsa03040 Spliceosome BYSL 495.5390127 602.8838452 388.1941801 0.643895475 -0.635101583 0.121284907 1 17.77295688 11.93688446 705 bystin like "GO:0000462,GO:0001829,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0008283,GO:0016020,GO:0030515,GO:0030688,GO:0042254,GO:0043231,GO:0045177,GO:1904749" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|trophectodermal cell differentiation|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|cytoplasm|cytosol|rRNA processing|cell population proliferation|membrane|snoRNA binding|preribosome, small subunit precursor|ribosome biogenesis|intracellular membrane-bounded organelle|apical part of cell|regulation of protein localization to nucleolus" BZW1 2013.040947 2064.42044 1961.661453 0.950223809 -0.073660739 0.820309971 1 31.20131675 30.92535973 9689 basic leucine zipper and W2 domains 1 "GO:0003723,GO:0005737,GO:0016020,GO:0045296" RNA binding|cytoplasm|membrane|cadherin binding BZW2 1035.966939 1209.827514 862.1063645 0.712586178 -0.488863595 0.162997821 1 30.46916737 22.64716845 28969 basic leucine zipper and W2 domains 2 "GO:0005515,GO:0005737,GO:0007399,GO:0016020,GO:0030154,GO:0045296" protein binding|cytoplasm|nervous system development|membrane|cell differentiation|cadherin binding C10orf143 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.079408763 0.080406278 387723 chromosome 10 open reading frame 143 C10orf88 194.7691093 180.6621624 208.8760563 1.156169358 0.209352742 0.706104761 1 3.141057736 3.788029079 80007 chromosome 10 open reading frame 88 "GO:0005515,GO:0005737,GO:0005739,GO:0016887,GO:0042802" protein binding|cytoplasm|mitochondrion|ATPase activity|identical protein binding C10orf90 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.030743983 0.010376727 118611 chromosome 10 open reading frame 90 "GO:0000209,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0008017,GO:0015629,GO:0016567,GO:0046599,GO:0050821,GO:0061630" protein polyubiquitination|nucleoplasm|cytoplasm|centrosome|centriole|cytosol|plasma membrane|microtubule binding|actin cytoskeleton|protein ubiquitination|regulation of centriole replication|protein stabilization|ubiquitin protein ligase activity C10orf95 7.47855778 6.08973581 8.867379749 1.456118956 0.542128219 0.797747104 1 0.209954823 0.318888341 79946 chromosome 10 open reading frame 95 C11orf1 337.0816722 345.0850292 329.0783151 0.953615159 -0.068520925 0.88677287 1 6.327783977 6.294202635 64776 chromosome 11 open reading frame 1 "GO:0003674,GO:0005515,GO:0005654,GO:0008150" molecular_function|protein binding|nucleoplasm|biological_process C11orf24 1129.178347 1216.932206 1041.424488 0.855778558 -0.224690563 0.515925877 1 25.66985554 22.91399189 53838 chromosome 11 open reading frame 24 "GO:0005515,GO:0005654,GO:0005794,GO:0005886,GO:0016021,GO:0043231" protein binding|nucleoplasm|Golgi apparatus|plasma membrane|integral component of membrane|intracellular membrane-bounded organelle C11orf49 768.9323209 635.3624362 902.5022056 1.42045257 0.50635066 0.171755787 1 6.540419912 9.690547145 79096 chromosome 11 open reading frame 49 GO:0005515 protein binding C11orf52 21.8985038 15.22433953 28.57266808 1.876775543 0.908256118 0.41099942 1 0.698423088 1.367246601 91894 chromosome 11 open reading frame 52 "GO:0005515,GO:0070062" protein binding|extracellular exosome C11orf54 358.5617727 365.3841486 351.7393967 0.962656421 -0.054907114 0.908561857 1 3.328312613 3.34203776 28970 chromosome 11 open reading frame 54 "GO:0005515,GO:0005634,GO:0005654,GO:0008270,GO:0016604,GO:0016788,GO:0070062" "protein binding|nucleus|nucleoplasm|zinc ion binding|nuclear body|hydrolase activity, acting on ester bonds|extracellular exosome" C11orf58 2875.060466 2765.755014 2984.365918 1.079042035 0.109751067 0.73083517 1 22.64399199 25.48632903 10944 chromosome 11 open reading frame 58 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process C11orf65 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.060475223 0.036740939 160140 chromosome 11 open reading frame 65 "GO:0005515,GO:0005741,GO:0005829,GO:0090258,GO:1903215" protein binding|mitochondrial outer membrane|cytosol|negative regulation of mitochondrial fission|negative regulation of protein targeting to mitochondrion C11orf68 837.6551328 719.6037816 955.7064841 1.328100975 0.409364839 0.260991358 1 23.33251788 32.32277452 83638 chromosome 11 open reading frame 68 "GO:0003723,GO:0005515" RNA binding|protein binding C11orf71 93.35170074 117.7348923 68.96850916 0.585794982 -0.771532259 0.266996363 1 2.706698571 1.653870386 54494 chromosome 11 open reading frame 71 "GO:0005654,GO:0016604" nucleoplasm|nuclear body C11orf80 468.7156706 385.683268 551.7480733 1.430573009 0.516593127 0.213906986 1 8.397892053 12.53130339 79703 chromosome 11 open reading frame 80 "GO:0005694,GO:0007131,GO:0042138" chromosome|reciprocal meiotic recombination|meiotic DNA double-strand break formation C11orf91 8.478667972 7.104691779 9.852644165 1.386779958 0.471738892 0.817532793 1 0.301110941 0.435562039 100131378 chromosome 11 open reading frame 91 C11orf94 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.57434569 0.581560488 143678 chromosome 11 open reading frame 94 GO:0005576 extracellular region C11orf96 28.85473782 19.2841634 38.42531225 1.992583834 0.994640424 0.324156397 1 0.786372662 1.63440973 387763 chromosome 11 open reading frame 96 C11orf98 6.463601811 4.059823873 8.867379749 2.184178434 1.12709072 0.538620937 1 0.318290646 0.725150114 102288414 chromosome 11 open reading frame 98 C12orf29 514.0742063 489.2087768 538.9396359 1.101655697 0.139673405 0.73388791 1 8.758111954 10.0640389 91298 chromosome 12 open reading frame 29 GO:0002244 hematopoietic progenitor cell differentiation C12orf4 302.7579995 389.7430919 215.7729072 0.553628561 -0.853009722 0.071174467 1 4.341128804 2.506900451 57102 chromosome 12 open reading frame 4 "GO:0005515,GO:0005737,GO:0043304" protein binding|cytoplasm|regulation of mast cell degranulation C12orf43 547.6865195 564.3155184 531.0575205 0.941064889 -0.087633891 0.830228284 1 5.927123646 5.818077299 64897 chromosome 12 open reading frame 43 "GO:0005515,GO:0005635,GO:0007275,GO:0016055,GO:0030178,GO:0060061" protein binding|nuclear envelope|multicellular organism development|Wnt signaling pathway|negative regulation of Wnt signaling pathway|Spemann organizer formation C12orf57 1662.211594 1520.404041 1804.019147 1.1865393 0.246759886 0.451624702 1 86.81296617 107.4441198 113246 chromosome 12 open reading frame 57 "GO:0003674,GO:0005515,GO:0005737,GO:0009791,GO:0014819,GO:0016607,GO:0021540,GO:0021678,GO:0036343,GO:0048593,GO:0050890" molecular_function|protein binding|cytoplasm|post-embryonic development|regulation of skeletal muscle contraction|nuclear speck|corpus callosum morphogenesis|third ventricle development|psychomotor behavior|camera-type eye morphogenesis|cognition C12orf60 31.1667195 42.62815067 19.70528833 0.462259986 -1.113223609 0.257352675 1 0.55629102 0.268228105 144608 chromosome 12 open reading frame 60 GO:0005515 protein binding C12orf73 196.5614889 168.4826908 224.640287 1.333313743 0.415016302 0.445977085 1 2.376233338 3.304740553 728568 chromosome 12 open reading frame 73 "GO:0005515,GO:0005739,GO:0005743,GO:0016021,GO:0034551" protein binding|mitochondrion|mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex III assembly C12orf75 1342.030596 1151.975024 1532.086168 1.329964744 0.411388002 0.221603227 1 44.50302902 61.7370153 387882 chromosome 12 open reading frame 75 C12orf76 139.2555708 123.8246281 154.6865134 1.249238667 0.32104913 0.602300184 1 3.533115824 4.60382941 400073 chromosome 12 open reading frame 76 C13orf46 29.27041955 47.70293051 10.83790858 0.227195865 -2.137991514 0.038072888 0.888192633 0.429432127 0.101767917 100507747 chromosome 13 open reading frame 46 C14orf119 1637.879374 1877.668541 1398.090207 0.744588396 -0.425484963 0.194928263 1 68.96104975 53.55944366 55017 chromosome 14 open reading frame 119 "GO:0005515,GO:0005739,GO:0005829" protein binding|mitochondrion|cytosol C14orf132 1822.304445 2226.813395 1417.795495 0.636692549 -0.651331215 0.045347048 0.96408227 12.18455518 8.091990717 56967 chromosome 14 open reading frame 132 GO:0016021 integral component of membrane C14orf28 82.26413558 66.98709391 97.54117724 1.456118956 0.542128219 0.457421916 1 1.113442727 1.691144308 122525 chromosome 14 open reading frame 28 C14orf93 320.5751527 294.3372308 346.8130746 1.178284764 0.236688247 0.612463877 1 2.281123547 2.80359321 60686 chromosome 14 open reading frame 93 "GO:0003723,GO:0005515,GO:0005576,GO:0010628,GO:0030154,GO:0048856" RNA binding|protein binding|extracellular region|positive regulation of gene expression|cell differentiation|anatomical structure development C15orf39 483.9021538 514.582676 453.2216316 0.880755713 -0.183186167 0.659254399 1 5.889671683 5.410812498 56905 chromosome 15 open reading frame 39 GO:0005829 cytosol C15orf40 502.560073 544.016399 461.1037469 0.847591631 -0.238558752 0.560587324 1 2.09190733 1.849460376 123207 chromosome 15 open reading frame 40 GO:0005737 cytoplasm C15orf48 158.2764696 279.1128913 37.44004783 0.134139443 -2.898194576 4.35E-06 0.001280867 21.78133019 3.04759202 84419 chromosome 15 open reading frame 48 "GO:0004129,GO:0005515,GO:0005634,GO:0005751,GO:0022900,GO:1902600" cytochrome-c oxidase activity|protein binding|nucleus|mitochondrial respiratory chain complex IV|electron transport chain|proton transmembrane transport C15orf61 90.4580122 88.30116925 92.61485516 1.048851968 0.068811075 0.938257814 1 1.066573507 1.166865821 145853 chromosome 15 open reading frame 61 GO:0005576 extracellular region C15orf62 159.6586106 171.5275587 147.7896625 0.86160885 -0.214895027 0.718095962 1 3.517111633 3.160910751 643338 chromosome 15 open reading frame 62 "GO:0005737,GO:0005739,GO:0005856,GO:0005886,GO:0007266,GO:0008360,GO:0030838,GO:0031274" cytoplasm|mitochondrion|cytoskeleton|plasma membrane|Rho protein signal transduction|regulation of cell shape|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly C15orf65 45.43820777 41.6131947 49.26322083 1.183836549 0.243469904 0.800416155 1 2.428066255 2.998252518 145788 chromosome 15 open reading frame 65 GO:0005515 protein binding C16orf46 21.04685137 24.35894324 17.7347595 0.728059478 -0.457871781 0.702946499 1 0.433636043 0.329312459 123775 chromosome 16 open reading frame 46 "GO:0005654,GO:0005829" nucleoplasm|cytosol C16orf72 913.6377753 929.699667 897.5758835 0.965447139 -0.050730826 0.890239469 1 4.268903749 4.298934147 29035 chromosome 16 open reading frame 72 GO:0005515 protein binding C16orf74 113.9383331 110.6302006 117.2464656 1.059805234 0.083799157 0.910748575 1 6.150416441 6.799023031 404550 chromosome 16 open reading frame 74 GO:0005515 protein binding C16orf86 16.04630041 19.2841634 12.80843742 0.664194611 -0.590322077 0.648095474 1 0.319070515 0.221053782 388284 chromosome 16 open reading frame 86 C16orf87 118.8470878 143.1087915 94.58538399 0.660933427 -0.597423133 0.352147076 1 0.977208499 0.673691212 388272 chromosome 16 open reading frame 87 GO:0005515 protein binding C16orf91 150.4200864 146.1536594 154.6865134 1.05838276 0.081861466 0.900998359 1 8.072156218 8.91144733 283951 chromosome 16 open reading frame 91 GO:0016021 integral component of membrane C16orf95 32.9145617 27.40381115 38.42531225 1.402188624 0.487680435 0.627392172 1 1.242530313 1.817311445 100506581 chromosome 16 open reading frame 95 C17orf100 36.06335003 40.59823873 31.52846133 0.776596776 -0.364762376 0.715421742 1 1.198925697 0.97118906 388327 chromosome 17 open reading frame 100 C17orf107 14.98680711 14.20938356 15.76423066 1.109423966 0.149810797 0.961565511 1 0.224821977 0.260167016 100130311 chromosome 17 open reading frame 107 C17orf113 42.52695184 44.65806261 40.39584108 0.904558745 -0.144713895 0.896452152 1 0.605886238 0.571667884 110806298 chromosome 17 open reading frame 113 GO:0016021 integral component of membrane C17orf49 607.6661611 589.6894176 625.6429045 1.060970209 0.085384147 0.830177177 1 34.97153244 38.70203332 124944 chromosome 17 open reading frame 49 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0006325,GO:0016589,GO:0042802,GO:0071339" DNA binding|protein binding|nucleoplasm|cytosol|chromatin organization|NURF complex|identical protein binding|MLL1 complex other C17orf58 168.5408361 172.5425146 164.5391576 0.953615159 -0.068520925 0.914757248 1 4.673085386 4.648285475 284018 chromosome 17 open reading frame 58 GO:0062023 collagen-containing extracellular matrix C17orf67 165.4811224 165.4378228 165.524422 1.000523454 0.000754987 1 1 4.113324545 4.29275577 339210 chromosome 17 open reading frame 67 "GO:0005515,GO:0005576" protein binding|extracellular region C17orf75 376.2613974 430.3413306 322.1814642 0.748664935 -0.41760791 0.344639995 1 4.596218946 3.589253486 64149 chromosome 17 open reading frame 75 "GO:0003674,GO:0005515,GO:0005802,GO:0006886,GO:0031410,GO:0099041" molecular_function|protein binding|trans-Golgi network|intracellular protein transport|cytoplasmic vesicle|vesicle tethering to Golgi C17orf80 727.9790213 698.2897062 757.6683363 1.085034377 0.117740752 0.755815296 1 8.80186914 9.961720107 55028 chromosome 17 open reading frame 80 "GO:0003674,GO:0005515,GO:0008150,GO:0016021,GO:0070062" molecular_function|protein binding|biological_process|integral component of membrane|extracellular exosome C17orf97 33.62988054 42.62815067 24.63161041 0.577824982 -0.791295514 0.41320997 1 1.172713443 0.706812381 400566 chromosome 17 open reading frame 97 GO:0016598 protein arginylation C18orf21 261.9843331 262.8735958 261.0950704 0.993234294 -0.009794019 0.992981056 1 7.380055579 7.645876321 83608 chromosome 18 open reading frame 21 C18orf25 723.8395253 752.0823726 695.5966781 0.924894272 -0.11263964 0.7665303 1 6.782464206 6.543280373 147339 chromosome 18 open reading frame 25 "GO:0005515,GO:0006511,GO:0016567,GO:0061630" protein binding|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin protein ligase activity C18orf32 48.34946369 38.5683268 58.13060058 1.507210849 0.591881255 0.496904664 1 0.352081776 0.553520216 497661 chromosome 18 open reading frame 32 "GO:0005515,GO:0005783,GO:0005811,GO:0043123" protein binding|endoplasmic reticulum|lipid droplet|positive regulation of I-kappaB kinase/NF-kappaB signaling C18orf54 797.8464418 658.7064235 936.9864601 1.422464434 0.508392582 0.166862642 1 5.15389411 7.647030772 162681 chromosome 18 open reading frame 54 "GO:0005515,GO:0005576,GO:0008285" protein binding|extracellular region|negative regulation of cell population proliferation C19orf12 432.4538823 398.8776956 466.030069 1.168353293 0.22447659 0.599193255 1 2.908400248 3.544412746 83636 chromosome 19 open reading frame 12 "GO:0005739,GO:0005783,GO:0005829,GO:0006914,GO:0006915,GO:0006979,GO:0016021,GO:0031966,GO:0051560" mitochondrion|endoplasmic reticulum|cytosol|autophagy|apoptotic process|response to oxidative stress|integral component of membrane|mitochondrial membrane|mitochondrial calcium ion homeostasis C19orf25 409.4068105 372.4888404 446.3247807 1.198223228 0.260896706 0.546797517 1 8.230909993 10.28730264 148223 chromosome 19 open reading frame 25 GO:0005515 protein binding C19orf33 1009.661962 859.6677052 1159.656218 1.348958686 0.431846164 0.219785812 1 100.5522784 141.4837279 64073 chromosome 19 open reading frame 33 "GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0008150" nucleus|nucleoplasm|cytosol|plasma membrane|biological_process C19orf44 335.5862082 377.5636202 293.6087961 0.777640589 -0.362824572 0.428145342 1 4.809422887 3.901106586 84167 chromosome 19 open reading frame 44 GO:0005515 protein binding C19orf47 312.782112 300.4269666 325.1372575 1.082250575 0.114034567 0.812591071 1 1.279371565 1.444243591 126526 chromosome 19 open reading frame 47 "GO:0005515,GO:0005634,GO:0005654" protein binding|nucleus|nucleoplasm C19orf53 1209.739178 1302.188507 1117.289848 0.858009299 -0.220934811 0.518426217 1 73.52425201 65.80191599 28974 chromosome 19 open reading frame 53 C19orf54 304.0186527 307.5316584 300.505647 0.977153535 -0.033342832 0.951004835 1 3.711962248 3.783400246 284325 chromosome 19 open reading frame 54 C19orf71 4.493072978 4.059823873 4.926322083 1.213432463 0.279093814 1 1 0.30104796 0.38103707 100128569 chromosome 19 open reading frame 71 C19orf73 6.567522243 11.16451565 1.970528833 0.176499267 -2.5022659 0.161860904 1 0.762053008 0.14029559 55150 chromosome 19 open reading frame 73 GO:0005515 protein binding C1D 116.0424739 119.7648043 112.3201435 0.937839327 -0.092587316 0.898879115 1 2.602172815 2.545543399 10438 C1D nuclear receptor corepressor "GO:0000176,GO:0000178,GO:0000460,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0006915,GO:0010468" nuclear exosome (RNase complex)|exosome (RNase complex)|maturation of 5.8S rRNA|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|apoptotic process|regulation of gene expression hsa03018 RNA degradation C1GALT1 408.8317846 467.8947014 349.7688679 0.747537569 -0.419782007 0.330539514 1 2.933913086 2.28768486 56913 "core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1" "GO:0000139,GO:0001525,GO:0001822,GO:0005515,GO:0016021,GO:0016263,GO:0016266,GO:0016267,GO:0018215,GO:0030154,GO:0046872" "Golgi membrane|angiogenesis|kidney development|protein binding|integral component of membrane|glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|O-glycan processing|O-glycan processing, core 1|protein phosphopantetheinylation|cell differentiation|metal ion binding" "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis C1GALT1C1 833.7922634 859.6677052 807.9168216 0.939801294 -0.089572341 0.808421345 1 24.08138083 23.60659527 29071 C1GALT1 specific chaperone 1 "GO:0000139,GO:0005515,GO:0006493,GO:0016021,GO:0016263,GO:0016266,GO:0016267,GO:0018215,GO:0030168,GO:0036344,GO:0070062" "Golgi membrane|protein binding|protein O-linked glycosylation|integral component of membrane|glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|O-glycan processing|O-glycan processing, core 1|protein phosphopantetheinylation|platelet activation|platelet morphogenesis|extracellular exosome" "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis C1GALT1C1L 53.90202996 47.70293051 60.10112941 1.259904345 0.333314205 0.701228552 1 1.888964148 2.482431185 728819 C1GALT1 specific chaperone 1 like "GO:0016021,GO:0016263,GO:0016267,GO:0018215" "integral component of membrane|glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|O-glycan processing, core 1|protein phosphopantetheinylation" "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis C1QBP 2925.269365 3436.640909 2413.897821 0.702400363 -0.509634505 0.109732599 1 148.8911363 109.0861215 708 complement C1q binding protein "GO:0000122,GO:0001849,GO:0003714,GO:0003729,GO:0005080,GO:0005515,GO:0005540,GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006397,GO:0006915,GO:0006955,GO:0006958,GO:0007597,GO:0008134,GO:0008380,GO:0008494,GO:0009986,GO:0014065,GO:0016020,GO:0016032,GO:0030449,GO:0030984,GO:0031690,GO:0032689,GO:0032695,GO:0039534,GO:0039536,GO:0042256,GO:0043065,GO:0045087,GO:0045785,GO:0048025,GO:0048786,GO:0050687,GO:0051897,GO:0070131,GO:0090023,GO:0097177,GO:0098978,GO:0098982,GO:1900026,GO:1901165,GO:2000510" "negative regulation of transcription by RNA polymerase II|complement component C1q complex binding|transcription corepressor activity|mRNA binding|protein kinase C binding|protein binding|hyaluronic acid binding|extracellular space|nucleus|nucleolus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|plasma membrane|mRNA processing|apoptotic process|immune response|complement activation, classical pathway|blood coagulation, intrinsic pathway|transcription factor binding|RNA splicing|translation activator activity|cell surface|phosphatidylinositol 3-kinase signaling|membrane|viral process|regulation of complement activation|kininogen binding|adrenergic receptor binding|negative regulation of interferon-gamma production|negative regulation of interleukin-12 production|negative regulation of MDA-5 signaling pathway|negative regulation of RIG-I signaling pathway|mature ribosome assembly|positive regulation of apoptotic process|innate immune response|positive regulation of cell adhesion|negative regulation of mRNA splicing, via spliceosome|presynaptic active zone|negative regulation of defense response to virus|positive regulation of protein kinase B signaling|positive regulation of mitochondrial translation|positive regulation of neutrophil chemotaxis|mitochondrial ribosome binding|glutamatergic synapse|GABA-ergic synapse|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of trophoblast cell migration|positive regulation of dendritic cell chemotaxis" C1QL1 71.28989341 91.34603715 51.23374966 0.56087545 -0.834247659 0.27229414 1 3.029701724 1.772483636 10882 complement C1q like 1 "GO:0003674,GO:0005102,GO:0005515,GO:0005575,GO:0005581,GO:0005737,GO:0007626,GO:0016322,GO:0043083,GO:0044301,GO:0061743,GO:0098793,GO:0099558" molecular_function|signaling receptor binding|protein binding|cellular_component|collagen trimer|cytoplasm|locomotory behavior|neuron remodeling|synaptic cleft|climbing fiber|motor learning|presynapse|maintenance of synapse structure C1QL4 91.69837641 72.06187375 111.3348791 1.544990066 0.627597562 0.370640189 1 1.76057872 2.837246502 338761 complement C1q like 4 "GO:0005515,GO:0005581,GO:0005615,GO:0042802,GO:0045599,GO:0048147,GO:0070373" protein binding|collagen trimer|extracellular space|identical protein binding|negative regulation of fat cell differentiation|negative regulation of fibroblast proliferation|negative regulation of ERK1 and ERK2 cascade C1QTNF1 924.0488696 1405.714016 442.383723 0.314703928 -1.667932907 5.30E-06 0.001497006 14.86314319 4.878976828 114897 C1q and TNF related 1 "GO:0005515,GO:0005518,GO:0005581,GO:0005615,GO:0005887,GO:0007204,GO:0010544,GO:0010628,GO:0010906,GO:0042802,GO:0043410,GO:0051897,GO:0090331,GO:2000860" protein binding|collagen binding|collagen trimer|extracellular space|integral component of plasma membrane|positive regulation of cytosolic calcium ion concentration|negative regulation of platelet activation|positive regulation of gene expression|regulation of glucose metabolic process|identical protein binding|positive regulation of MAPK cascade|positive regulation of protein kinase B signaling|negative regulation of platelet aggregation|positive regulation of aldosterone secretion C1QTNF2 123.7370373 39.58328277 207.8907919 5.25198461 2.392862689 0.000329196 0.041898412 0.740034563 4.05407126 114898 C1q and TNF related 2 "GO:0005515,GO:0005576,GO:0005581,GO:0019216" protein binding|extracellular region|collagen trimer|regulation of lipid metabolic process C1QTNF3 17.4202766 12.17947162 22.66108158 1.860596443 0.895765174 0.45402894 1 0.163489868 0.317291881 114899 C1q and TNF related 3 "GO:0001819,GO:0003674,GO:0005515,GO:0005581,GO:0016020,GO:0032715,GO:0035356,GO:0042802,GO:0045444,GO:0045721,GO:0050728,GO:0070062,GO:0070165,GO:0071638,GO:1901223" positive regulation of cytokine production|molecular_function|protein binding|collagen trimer|membrane|negative regulation of interleukin-6 production|cellular triglyceride homeostasis|identical protein binding|fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of inflammatory response|extracellular exosome|positive regulation of adiponectin secretion|negative regulation of monocyte chemotactic protein-1 production|negative regulation of NIK/NF-kappaB signaling C1QTNF6 137.985515 138.0340117 137.9370183 0.999297323 -0.001014106 1 1 0.792712976 0.826278821 114904 C1q and TNF related 6 "GO:0005515,GO:0005581,GO:0005615,GO:0042802" protein binding|collagen trimer|extracellular space|identical protein binding C1R 907.2471646 762.2319322 1052.262397 1.380501593 0.465192553 0.1947126 1 14.79661111 21.30664655 715 complement C1r "GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006955,GO:0006956,GO:0006958,GO:0008236,GO:0030449,GO:0031638,GO:0042802,GO:0045087,GO:0070062,GO:0072562" "serine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|extracellular space|immune response|complement activation|complement activation, classical pathway|serine-type peptidase activity|regulation of complement activation|zymogen activation|identical protein binding|innate immune response|extracellular exosome|blood microparticle" "hsa04145,hsa04610,hsa05133,hsa05150,hsa05171,hsa05322" Phagosome|Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C1RL 604.9506218 572.4351662 637.4660775 1.113603977 0.155236268 0.693253586 1 7.888931085 9.163573447 51279 complement C1r subcomponent like "GO:0004252,GO:0005615,GO:0006958,GO:0031638,GO:0045087,GO:0070062,GO:0072562" "serine-type endopeptidase activity|extracellular space|complement activation, classical pathway|zymogen activation|innate immune response|extracellular exosome|blood microparticle" C1S 107.5341144 110.6302006 104.4380282 0.944028192 -0.083098151 0.914116017 1 1.914910929 1.885599574 716 complement C1s "GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0006956,GO:0006958,GO:0030449,GO:0042802,GO:0045087,GO:0072562" "serine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|extracellular space|proteolysis|complement activation|complement activation, classical pathway|regulation of complement activation|identical protein binding|innate immune response|blood microparticle" "hsa04610,hsa05133,hsa05150,hsa05171,hsa05322" Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C1orf109 435.4960286 438.4609783 432.5310789 0.986475651 -0.019644654 0.968958455 1 6.704861641 6.899094918 54955 chromosome 1 open reading frame 109 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol C1orf112 525.7813347 447.5955821 603.9670873 1.349358911 0.432274137 0.284362724 1 4.753436194 6.690384536 55732 chromosome 1 open reading frame 112 GO:0005515 protein binding C1orf115 547.2884051 503.4181603 591.1586499 1.17428948 0.231788099 0.563559769 1 8.819216142 10.80242069 79762 chromosome 1 open reading frame 115 "GO:0016021,GO:0097731" integral component of membrane|9+0 non-motile cilium C1orf116 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.018685547 0.037840541 79098 chromosome 1 open reading frame 116 "GO:0003674,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0070062" molecular_function|protein binding|cytoplasm|cytosol|plasma membrane|biological_process|extracellular exosome C1orf122 428.376491 423.2366388 433.5163433 1.024288314 0.034621859 0.940902867 1 17.92261093 19.14870571 127687 chromosome 1 open reading frame 122 C1orf131 137.1338626 147.1686154 127.0991097 0.863629174 -0.211516116 0.736996829 1 5.212287546 4.695389244 128061 chromosome 1 open reading frame 131 "GO:0003723,GO:0005694" RNA binding|chromosome C1orf159 447.1410523 426.2815067 468.0005979 1.097867467 0.134703904 0.752494551 1 8.877325035 10.16594994 54991 chromosome 1 open reading frame 159 GO:0016021 integral component of membrane C1orf162 39.06368061 43.64310664 34.48425458 0.790142069 -0.339816019 0.728410972 1 0.307979572 0.253830045 128346 chromosome 1 open reading frame 162 GO:0016021 integral component of membrane C1orf174 691.3703369 755.1272405 627.6134333 0.831135999 -0.26684353 0.481934007 1 8.988138849 7.792158821 339448 chromosome 1 open reading frame 174 "GO:0005515,GO:0005654" protein binding|nucleoplasm C1orf198 323.2313089 307.5316584 338.9309593 1.102101036 0.14025649 0.766362379 1 3.58962747 4.126546281 84886 chromosome 1 open reading frame 198 GO:0005829 cytosol C1orf21 649.0136156 452.6703619 845.3568694 1.867488885 0.901099656 0.019537711 0.604436841 2.227354212 4.338736176 81563 chromosome 1 open reading frame 21 GO:0005515 protein binding C1orf216 570.4245515 535.8967513 604.9523518 1.128859898 0.174866445 0.660855237 1 8.930990432 10.51612159 127703 chromosome 1 open reading frame 216 GO:0005515 protein binding C1orf226 125.2540281 109.6152446 140.8928116 1.285339572 0.362149553 0.569802747 1 1.287184196 1.725736589 400793 chromosome 1 open reading frame 226 C1orf35 349.5162436 353.204677 345.8278102 0.97911447 -0.030450557 0.952971811 1 13.86710919 14.16235036 79169 chromosome 1 open reading frame 35 "GO:0003723,GO:0005515,GO:0005576,GO:0034774,GO:0043312,GO:1904813" RNA binding|protein binding|extracellular region|secretory granule lumen|neutrophil degranulation|ficolin-1-rich granule lumen C1orf43 3499.747305 3508.702783 3490.791828 0.994895277 -0.007383419 0.982481596 1 70.04470555 72.68898641 25912 chromosome 1 open reading frame 43 "GO:0005739,GO:0005794,GO:0006909,GO:0016021" mitochondrion|Golgi apparatus|phagocytosis|integral component of membrane C1orf50 259.9841127 260.8436839 259.1245416 0.993409301 -0.009539841 0.993482168 1 2.775380754 2.875853268 79078 chromosome 1 open reading frame 50 "GO:0005515,GO:0042802" protein binding|identical protein binding C1orf52 643.8455557 671.9008511 615.7902603 0.916489776 -0.125809309 0.746395858 1 3.743609217 3.578772257 148423 chromosome 1 open reading frame 52 "GO:0003723,GO:0005654" RNA binding|nucleoplasm C1orf53 37.46701778 35.52345889 39.41057666 1.109423966 0.149810797 0.899447359 1 2.998563123 3.46997758 388722 chromosome 1 open reading frame 53 C1orf54 7.448866228 4.059823873 10.83790858 2.669551419 1.416597337 0.391522599 1 0.246837643 0.687330493 79630 chromosome 1 open reading frame 54 GO:0005576 extracellular region C1orf56 107.0117906 108.6002886 105.4232926 0.970745971 -0.042834281 0.963814556 1 2.637995923 2.671133821 54964 chromosome 1 open reading frame 56 "GO:0003674,GO:0005515,GO:0005575,GO:0005576,GO:0042127" molecular_function|protein binding|cellular_component|extracellular region|regulation of cell population proliferation C1orf74 158.7799882 145.1387035 172.4212729 1.187975838 0.248505494 0.675260132 1 1.56933461 1.944639443 148304 chromosome 1 open reading frame 74 GO:0005515 protein binding C2 6.060044258 10.14955968 1.970528833 0.194149194 -2.364762376 0.199637567 1 0.14006523 0.028364939 717 complement C2 "GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0006956,GO:0006958,GO:0007584,GO:0030449,GO:0045087,GO:0046872,GO:0070062,GO:2000427" "serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|proteolysis|complement activation|complement activation, classical pathway|response to nutrient|regulation of complement activation|innate immune response|metal ion binding|extracellular exosome|positive regulation of apoptotic cell clearance" "hsa04610,hsa05133,hsa05150,hsa05171,hsa05322" Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C20orf202 1.970528833 0 3.941057666 Inf Inf 0.26888406 1 0 0.129396305 400831 chromosome 20 open reading frame 202 GO:0005515 protein binding C20orf204 9.075220612 14.20938356 3.941057666 0.277355992 -1.850189203 0.218517863 1 0.267828489 0.077483682 284739 chromosome 20 open reading frame 204 C20orf27 1821.393656 1861.429246 1781.358065 0.956984032 -0.063433242 0.846513693 1 52.93364659 52.83873778 54976 chromosome 20 open reading frame 27 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process C20orf96 283.2632737 370.4589285 196.0676189 0.529256022 -0.917962314 0.057471893 1 11.87496065 6.555622201 140680 chromosome 20 open reading frame 96 C21orf58 360.582282 301.4419226 419.7226414 1.392383109 0.477556218 0.285736418 1 3.065656618 4.452441112 54058 chromosome 21 open reading frame 58 C21orf91 142.2531797 160.363043 124.1433165 0.774139192 -0.369335106 0.544225377 1 1.505156116 1.215392444 54149 chromosome 21 open reading frame 91 "GO:0021895,GO:0060999" cerebral cortex neuron differentiation|positive regulation of dendritic spine development C22orf23 15.94237998 12.17947162 19.70528833 1.617909951 0.694131313 0.584370786 1 0.284786367 0.480606313 84645 chromosome 22 open reading frame 23 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process C22orf39 516.2849892 471.9545253 560.615453 1.187859048 0.248363655 0.541676967 1 6.425492406 7.961359852 128977 chromosome 22 open reading frame 39 GO:0005515 protein binding C2CD2 1789.564319 1706.140983 1872.987656 1.097791844 0.134604526 0.679803401 1 10.99084481 12.58539948 25966 C2 calcium dependent domain containing 2 "GO:0005634,GO:0005829,GO:0016021" nucleus|cytosol|integral component of membrane C2CD2L 560.1332151 606.9436691 513.322761 0.845750252 -0.241696393 0.544505359 1 4.610702815 4.067477845 9854 C2CD2 like "GO:0005515,GO:0005789,GO:0008526,GO:0015914,GO:0016021,GO:0032541,GO:0035091,GO:0035774,GO:0043559,GO:0098592,GO:0120009,GO:0140268" protein binding|endoplasmic reticulum membrane|phosphatidylinositol transfer activity|phospholipid transport|integral component of membrane|cortical endoplasmic reticulum|phosphatidylinositol binding|positive regulation of insulin secretion involved in cellular response to glucose stimulus|insulin binding|cytoplasmic side of apical plasma membrane|intermembrane lipid transfer|endoplasmic reticulum-plasma membrane contact site C2CD3 887.3137464 813.9946866 960.6328061 1.180146286 0.238965701 0.507726381 1 4.577610402 5.63495693 26005 C2 domain containing 3 centriole elongation regulator "GO:0001701,GO:0001947,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007420,GO:0008589,GO:0016485,GO:0021915,GO:0021997,GO:0030162,GO:0034451,GO:0036064,GO:0042733,GO:0061511,GO:0071539,GO:0097711,GO:1905515" in utero embryonic development|heart looping|protein binding|centrosome|centriole|cytosol|brain development|regulation of smoothened signaling pathway|protein processing|neural tube development|neural plate axis specification|regulation of proteolysis|centriolar satellite|ciliary basal body|embryonic digit morphogenesis|centriole elongation|protein localization to centrosome|ciliary basal body-plasma membrane docking|non-motile cilium assembly C2CD4C 22.39113601 15.22433953 29.5579325 1.941491941 0.957165719 0.381715768 1 0.248008713 0.502248283 126567 C2 calcium dependent domain containing 4C GO:0005829 cytosol C2CD5 1136.573274 1149.945112 1123.201435 0.976743518 -0.033948318 0.924177623 1 11.80155282 12.02363052 9847 C2 calcium dependent domain containing 5 "GO:0005509,GO:0005544,GO:0005829,GO:0005886,GO:0005938,GO:0010828,GO:0030659,GO:0031340,GO:0032587,GO:0032869,GO:0034451,GO:0038028,GO:0065002,GO:0072659,GO:0090314" calcium ion binding|calcium-dependent phospholipid binding|cytosol|plasma membrane|cell cortex|positive regulation of glucose transmembrane transport|cytoplasmic vesicle membrane|positive regulation of vesicle fusion|ruffle membrane|cellular response to insulin stimulus|centriolar satellite|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|intracellular protein transmembrane transport|protein localization to plasma membrane|positive regulation of protein targeting to membrane C2orf15 24.3913564 17.25425146 31.52846133 1.827286533 0.869702877 0.415654023 1 0.507177578 0.966679767 150590 chromosome 2 open reading frame 15 "GO:0003723,GO:0005515" RNA binding|protein binding C2orf42 148.2120252 129.914364 166.5096864 1.281688039 0.358045155 0.551370992 1 1.986026026 2.655114146 54980 chromosome 2 open reading frame 42 "GO:0005515,GO:0005634,GO:0005654" protein binding|nucleus|nucleoplasm C2orf49 455.0677049 429.3263746 480.8090353 1.119914973 0.163389203 0.699498453 1 1.883890686 2.200678902 79074 chromosome 2 open reading frame 49 "GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0006388,GO:0008150,GO:0048598,GO:0072669" "molecular_function|protein binding|nucleus|nucleoplasm|tRNA splicing, via endonucleolytic cleavage and ligation|biological_process|embryonic morphogenesis|tRNA-splicing ligase complex" C2orf50 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.007100972 0.035950866 130813 chromosome 2 open reading frame 50 GO:0005515 protein binding C2orf66 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.115687785 0.03904701 401027 chromosome 2 open reading frame 66 GO:0005576 extracellular region C2orf68 519.8076435 477.0293051 562.5859818 1.179353083 0.237995708 0.558170354 1 5.262437693 6.473613151 388969 chromosome 2 open reading frame 68 GO:0005515 protein binding C2orf69 379.0741761 353.204677 404.9436752 1.146484465 0.197216807 0.657511722 1 4.846537756 5.795830882 205327 chromosome 2 open reading frame 69 GO:0005576 extracellular region C2orf76 47.48296548 46.68797455 48.27795641 1.03405549 0.048313607 0.982714706 1 0.526398309 0.567772378 130355 chromosome 2 open reading frame 76 GO:0005515 protein binding C2orf81 60.27383551 79.16656553 41.38110549 0.522709369 -0.935919077 0.243429692 1 1.739482543 0.948410358 388963 chromosome 2 open reading frame 81 C2orf88 15.53882242 18.26920743 12.80843742 0.701094312 -0.512319565 0.703786644 1 0.165285978 0.120872745 84281 chromosome 2 open reading frame 88 "GO:0005515,GO:0005886,GO:0034237" protein binding|plasma membrane|protein kinase A regulatory subunit binding C2orf92 21.91334958 16.23929549 27.58740366 1.698805448 0.764520641 0.493262248 1 0.279084842 0.494533622 728537 chromosome 2 open reading frame 92 GO:0016021 integral component of membrane C3 21538.66063 25851.94347 17225.37779 0.666308814 -0.585737117 0.112242524 1 250.2981718 173.9599064 718 complement C3 "GO:0001798,GO:0001934,GO:0001970,GO:0004866,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006631,GO:0006954,GO:0006955,GO:0006956,GO:0006957,GO:0006958,GO:0007165,GO:0007186,GO:0009617,GO:0009986,GO:0010575,GO:0010828,GO:0010866,GO:0010884,GO:0010951,GO:0016322,GO:0030449,GO:0031715,GO:0032991,GO:0034774,GO:0035578,GO:0035846,GO:0043312,GO:0043687,GO:0044267,GO:0045745,GO:0045766,GO:0048260,GO:0050776,GO:0060100,GO:0070062,GO:0072562,GO:0097242,GO:0097278,GO:0150062,GO:0150064,GO:1905114,GO:2000427" "positive regulation of type IIa hypersensitivity|positive regulation of protein phosphorylation|positive regulation of activation of membrane attack complex|endopeptidase inhibitor activity|signaling receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|fatty acid metabolic process|inflammatory response|immune response|complement activation|complement activation, alternative pathway|complement activation, classical pathway|signal transduction|G protein-coupled receptor signaling pathway|response to bacterium|cell surface|positive regulation of vascular endothelial growth factor production|positive regulation of glucose transmembrane transport|regulation of triglyceride biosynthetic process|positive regulation of lipid storage|negative regulation of endopeptidase activity|neuron remodeling|regulation of complement activation|C5L2 anaphylatoxin chemotactic receptor binding|protein-containing complex|secretory granule lumen|azurophil granule lumen|oviduct epithelium development|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|positive regulation of G protein-coupled receptor signaling pathway|positive regulation of angiogenesis|positive regulation of receptor-mediated endocytosis|regulation of immune response|positive regulation of phagocytosis, engulfment|extracellular exosome|blood microparticle|amyloid-beta clearance|complement-dependent cytotoxicity|complement-mediated synapse pruning|vertebrate eye-specific patterning|cell surface receptor signaling pathway involved in cell-cell signaling|positive regulation of apoptotic cell clearance" "hsa04080,hsa04145,hsa04610,hsa05131,hsa05133,hsa05134,hsa05140,hsa05142,hsa05150,hsa05152,hsa05167,hsa05168,hsa05171,hsa05203,hsa05322" Neuroactive ligand-receptor interaction|Phagosome|Complement and coagulation cascades|Shigellosis|Pertussis|Legionellosis|Leishmaniasis|Chagas disease|Staphylococcus aureus infection|Tuberculosis|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19|Viral carcinogenesis|Systemic lupus erythematosus C3AR1 9.597544372 16.23929549 2.95579325 0.182014869 -2.457871781 0.104356556 1 0.235595253 0.044729015 719 complement C3a receptor 1 "GO:0002430,GO:0004875,GO:0004876,GO:0004930,GO:0005886,GO:0005887,GO:0006935,GO:0006954,GO:0007186,GO:0007200,GO:0007204,GO:0008015,GO:0010575,GO:0010759,GO:0030449,GO:0035577,GO:0035579,GO:0043312,GO:0045766,GO:0051482,GO:0090023" complement receptor mediated signaling pathway|complement receptor activity|complement component C3a receptor activity|G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|chemotaxis|inflammatory response|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|blood circulation|positive regulation of vascular endothelial growth factor production|positive regulation of macrophage chemotaxis|regulation of complement activation|azurophil granule membrane|specific granule membrane|neutrophil degranulation|positive regulation of angiogenesis|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of neutrophil chemotaxis "hsa04080,hsa04610,hsa05150,hsa05171" Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Staphylococcus aureus infection|Coronavirus disease - COVID-19 C3orf14 232.7732967 219.2304892 246.3161041 1.123548577 0.168062501 0.749130908 1 6.983176653 8.183909388 57415 chromosome 3 open reading frame 14 C3orf18 339.2627635 325.8008658 352.7246611 1.082638808 0.114552009 0.806539761 1 4.16473107 4.703124585 51161 chromosome 3 open reading frame 18 GO:0016021 integral component of membrane C3orf20 13.03112405 15.22433953 10.83790858 0.711880378 -0.490293258 0.74228548 1 0.137296846 0.101949128 84077 chromosome 3 open reading frame 20 "GO:0005737,GO:0016021" cytoplasm|integral component of membrane C3orf33 50.13912161 59.88240213 40.39584108 0.674586183 -0.567925326 0.509800579 1 0.917372177 0.645503996 285315 chromosome 3 open reading frame 33 "GO:0005515,GO:0005615,GO:0016021,GO:0051090,GO:0070373" protein binding|extracellular space|integral component of membrane|regulation of DNA-binding transcription factor activity|negative regulation of ERK1 and ERK2 cascade C3orf38 478.3077718 468.9096574 487.7058862 1.040084968 0.056701392 0.895760603 1 9.833797074 10.66856461 285237 chromosome 3 open reading frame 38 "GO:0003674,GO:0005634,GO:0006915,GO:0043065" molecular_function|nucleus|apoptotic process|positive regulation of apoptotic process C3orf52 284.6778278 231.4099608 337.9456949 1.460376614 0.546340471 0.256286235 1 5.239203464 7.980793318 79669 chromosome 3 open reading frame 52 "GO:0005515,GO:0005789,GO:0016021" protein binding|endoplasmic reticulum membrane|integral component of membrane C3orf62 185.2606396 170.5126027 200.0086766 1.172984714 0.230184213 0.682745638 1 2.304125345 2.819125329 375341 chromosome 3 open reading frame 62 GO:0005515 protein binding C3orf70 92.87663592 85.25630134 100.4969705 1.178762964 0.237273638 0.743394265 1 0.603147213 0.741593197 285382 chromosome 3 open reading frame 70 "GO:0007399,GO:0048512" nervous system development|circadian behavior C3orf80 13.53860204 16.23929549 10.83790858 0.667387855 -0.583402663 0.677251882 1 0.294578448 0.205066727 401097 chromosome 3 open reading frame 80 GO:0016021 integral component of membrane C4A 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.08599172 0.038698635 720 complement C4A (Rodgers blood group) "GO:0001849,GO:0004866,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006954,GO:0006956,GO:0006958,GO:0010951,GO:0030424,GO:0030425,GO:0030449,GO:0043025,GO:0043687,GO:0044267,GO:0045087,GO:0045202,GO:0070062,GO:0072562,GO:2000427" "complement component C1q complex binding|endopeptidase inhibitor activity|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|inflammatory response|complement activation|complement activation, classical pathway|negative regulation of endopeptidase activity|axon|dendrite|regulation of complement activation|neuronal cell body|post-translational protein modification|cellular protein metabolic process|innate immune response|synapse|extracellular exosome|blood microparticle|positive regulation of apoptotic cell clearance" "hsa04610,hsa05133,hsa05150,hsa05171,hsa05322" Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C4B 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.018943777 0.038363489 721 complement C4B (Chido blood group) "GO:0001848,GO:0004866,GO:0005576,GO:0005615,GO:0005886,GO:0006954,GO:0006956,GO:0006958,GO:0008228,GO:0010951,GO:0030246,GO:0030424,GO:0030425,GO:0030449,GO:0032490,GO:0044216,GO:0045087,GO:0045202,GO:0070062,GO:0072562,GO:2000427" "complement binding|endopeptidase inhibitor activity|extracellular region|extracellular space|plasma membrane|inflammatory response|complement activation|complement activation, classical pathway|opsonization|negative regulation of endopeptidase activity|carbohydrate binding|axon|dendrite|regulation of complement activation|detection of molecule of bacterial origin|other organism cell|innate immune response|synapse|extracellular exosome|blood microparticle|positive regulation of apoptotic cell clearance" "hsa04610,hsa05133,hsa05150,hsa05171,hsa05322" Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C4orf3 1034.567231 1349.891438 719.2430241 0.532815457 -0.908292158 0.009924459 0.419890621 23.80474903 13.22989363 401152 chromosome 4 open reading frame 3 GO:0016021 integral component of membrane C4orf33 153.554029 158.3331311 148.7749269 0.939632318 -0.089831761 0.889135096 1 2.013310199 1.973261165 132321 chromosome 4 open reading frame 33 GO:0005515 protein binding C4orf36 8.493513748 8.119647747 8.867379749 1.092089217 0.12709072 1 1 0.18942032 0.215774746 132989 chromosome 4 open reading frame 36 C4orf46 583.425984 549.0911789 617.7607892 1.125060487 0.170002568 0.668117016 1 8.261892791 9.695525593 201725 chromosome 4 open reading frame 46 "GO:0005515,GO:0005737" protein binding|cytoplasm C4orf47 38.82342659 60.8973581 16.74949508 0.275044692 -1.862262036 0.046982499 0.987288043 0.93490038 0.268215909 441054 chromosome 4 open reading frame 47 "GO:0005813,GO:0005881,GO:0097731" centrosome|cytoplasmic microtubule|9+0 non-motile cilium C4orf48 144.6569577 156.3032191 133.0106962 0.850978611 -0.232805225 0.70494706 1 4.30228622 3.818861196 401115 chromosome 4 open reading frame 48 GO:0005576 extracellular region C5 67.84418955 57.8524902 77.83588891 1.345419854 0.428056453 0.586324283 1 0.49202763 0.690499317 727 complement C5 "GO:0000187,GO:0001701,GO:0004866,GO:0005102,GO:0005515,GO:0005576,GO:0005579,GO:0005615,GO:0006935,GO:0006954,GO:0006957,GO:0006958,GO:0007166,GO:0007186,GO:0008009,GO:0010575,GO:0010760,GO:0010951,GO:0019835,GO:0030449,GO:0032722,GO:0045766,GO:0060326,GO:0070062" "activation of MAPK activity|in utero embryonic development|endopeptidase inhibitor activity|signaling receptor binding|protein binding|extracellular region|membrane attack complex|extracellular space|chemotaxis|inflammatory response|complement activation, alternative pathway|complement activation, classical pathway|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|chemokine activity|positive regulation of vascular endothelial growth factor production|negative regulation of macrophage chemotaxis|negative regulation of endopeptidase activity|cytolysis|regulation of complement activation|positive regulation of chemokine production|positive regulation of angiogenesis|cell chemotaxis|extracellular exosome" "hsa04080,hsa04610,hsa05020,hsa05133,hsa05150,hsa05168,hsa05171,hsa05322" Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Prion disease|Pertussis|Staphylococcus aureus infection|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C5AR1 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.067019478 0 728 complement C5a receptor 1 "GO:0000187,GO:0001774,GO:0001856,GO:0002430,GO:0004875,GO:0004878,GO:0004930,GO:0005886,GO:0005887,GO:0006915,GO:0006935,GO:0006954,GO:0006955,GO:0006968,GO:0007165,GO:0007186,GO:0007200,GO:0007202,GO:0007204,GO:0007606,GO:0009986,GO:0010575,GO:0010759,GO:0016323,GO:0021534,GO:0030449,GO:0030593,GO:0030667,GO:0031100,GO:0032494,GO:0032496,GO:0038178,GO:0042789,GO:0043312,GO:0043524,GO:0045177,GO:0045766,GO:0048143,GO:0050679,GO:0050830,GO:0050890,GO:0070374,GO:0090023,GO:0097242,GO:0099172,GO:1902947" activation of MAPK activity|microglial cell activation|complement component C5a binding|complement receptor mediated signaling pathway|complement receptor activity|complement component C5a receptor activity|G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|apoptotic process|chemotaxis|inflammatory response|immune response|cellular defense response|signal transduction|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|sensory perception of chemical stimulus|cell surface|positive regulation of vascular endothelial growth factor production|positive regulation of macrophage chemotaxis|basolateral plasma membrane|cell proliferation in hindbrain|regulation of complement activation|neutrophil chemotaxis|secretory granule membrane|animal organ regeneration|response to peptidoglycan|response to lipopolysaccharide|complement component C5a signaling pathway|mRNA transcription by RNA polymerase II|neutrophil degranulation|negative regulation of neuron apoptotic process|apical part of cell|positive regulation of angiogenesis|astrocyte activation|positive regulation of epithelial cell proliferation|defense response to Gram-positive bacterium|cognition|positive regulation of ERK1 and ERK2 cascade|positive regulation of neutrophil chemotaxis|amyloid-beta clearance|presynapse organization|regulation of tau-protein kinase activity "hsa04080,hsa04610,hsa05150,hsa05171" Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Staphylococcus aureus infection|Coronavirus disease - COVID-19 C5orf15 1892.917122 1834.025435 1951.808809 1.064221233 0.089798093 0.782549211 1 42.45288767 47.12540393 56951 chromosome 5 open reading frame 15 GO:0016021 integral component of membrane C5orf22 875.1558015 892.1462962 858.1653068 0.961910967 -0.056024728 0.879603149 1 11.618427 11.65730447 55322 chromosome 5 open reading frame 22 GO:0005515 protein binding C5orf24 2001.759148 1831.995523 2171.522774 1.185331922 0.245291106 0.446757833 1 15.96148466 19.7346394 134553 chromosome 5 open reading frame 24 GO:0005515 protein binding C5orf34 257.0783 196.9014579 317.2551421 1.611238157 0.688169755 0.166489119 1 2.294079644 3.855530645 375444 chromosome 5 open reading frame 34 C5orf51 198.6480623 210.0958855 187.2002391 0.891022871 -0.16646563 0.764749035 1 1.970484338 1.831377056 285636 chromosome 5 open reading frame 51 "GO:0005654,GO:0005829" nucleoplasm|cytosol C5orf63 37.98934154 37.55337083 38.42531225 1.023218726 0.033114572 1 1 0.293646094 0.313406961 401207 chromosome 5 open reading frame 63 GO:0055114 oxidation-reduction process C6orf120 638.7086712 691.1850145 586.2323278 0.848155437 -0.237599411 0.5388565 1 8.238663833 7.2886679 387263 chromosome 6 open reading frame 120 "GO:0005576,GO:0006915,GO:0035578,GO:0043312" extracellular region|apoptotic process|azurophil granule lumen|neutrophil degranulation C6orf132 26.72090545 8.119647747 45.32216316 5.58178933 2.480727675 0.02191773 0.644409785 0.064405875 0.374985831 647024 chromosome 6 open reading frame 132 C6orf136 227.0722726 199.9463258 254.1982195 1.271332286 0.346341155 0.505645634 1 6.856178762 9.09195209 221545 chromosome 6 open reading frame 136 C6orf141 340.2331821 324.7859099 355.6804544 1.095122798 0.131092651 0.778045327 1 5.885245281 6.722693595 135398 chromosome 6 open reading frame 141 "GO:0001835,GO:0005515" blastocyst hatching|protein binding C6orf163 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.229481872 0.077454857 206412 chromosome 6 open reading frame 163 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process C6orf226 46.96064172 44.65806261 49.26322083 1.103120421 0.14159029 0.893649532 1 4.060634339 4.672321697 441150 chromosome 6 open reading frame 226 GO:0005515 protein binding C6orf47 314.7998998 269.9782876 359.621512 1.332038644 0.413635937 0.375490728 1 5.511264748 7.657447502 57827 chromosome 6 open reading frame 47 GO:0005515 protein binding C6orf52 5.508028946 6.08973581 4.926322083 0.808954975 -0.305868687 0.976518791 1 0.193733439 0.163472562 347744 chromosome 6 open reading frame 52 C6orf58 5.059934066 9.134603715 0.985264417 0.107860663 -3.212759283 0.136251646 1 0.384568124 0.043266553 352999 chromosome 6 open reading frame 58 "GO:0005515,GO:0005615,GO:0007275,GO:0070062" protein binding|extracellular space|multicellular organism development|extracellular exosome C6orf62 2072.1771 1998.448302 2145.905899 1.073786046 0.102706562 0.750320514 1 19.66472827 22.02528999 81688 chromosome 6 open reading frame 62 "GO:0003674,GO:0008150" molecular_function|biological_process C6orf89 1818.612052 1738.619574 1898.604531 1.09201838 0.126997139 0.696631165 1 10.37894247 11.82221852 221477 chromosome 6 open reading frame 89 "GO:0000139,GO:0005515,GO:0005730,GO:0005737,GO:0005886,GO:0016021,GO:0030496,GO:0042060,GO:0045787,GO:0050673,GO:1901727" Golgi membrane|protein binding|nucleolus|cytoplasm|plasma membrane|integral component of membrane|midbody|wound healing|positive regulation of cell cycle|epithelial cell proliferation|positive regulation of histone deacetylase activity C7orf25 303.5381447 342.0401613 265.0361281 0.774868445 -0.3679767 0.436138517 1 3.670154137 2.966389732 79020 chromosome 7 open reading frame 25 GO:0005515 protein binding C7orf26 499.5206483 470.9395693 528.1017273 1.121378966 0.165273914 0.688804212 1 9.255501673 10.82600689 79034 chromosome 7 open reading frame 26 C7orf31 155.5272794 124.8395841 186.2149747 1.491634052 0.576893638 0.325560803 1 1.701933924 2.648017884 136895 chromosome 7 open reading frame 31 "GO:0005515,GO:0005737,GO:0005813" protein binding|cytoplasm|centrosome C7orf50 968.6571978 1188.513439 748.8009566 0.630031544 -0.666504033 0.060463302 1 13.08281088 8.597640604 84310 chromosome 7 open reading frame 50 "GO:0003723,GO:0005515" RNA binding|protein binding C7orf57 17.1057937 24.35894324 9.852644165 0.404477488 -1.305868687 0.270147201 1 0.759196641 0.320305623 136288 chromosome 7 open reading frame 57 C7orf61 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.156084836 0.263409229 402573 chromosome 7 open reading frame 61 GO:0005634 nucleus C8orf33 1271.644811 1324.517539 1218.772083 0.920163039 -0.120038588 0.724733656 1 24.43793833 23.45553151 65265 chromosome 8 open reading frame 33 GO:0005515 protein binding C8orf37 108.5342245 111.6451565 105.4232926 0.94427108 -0.082727008 0.914170225 1 1.692944107 1.667459286 157657 chromosome 8 open reading frame 37 "GO:0001917,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0008594,GO:0030054,GO:0097546" photoreceptor inner segment|protein binding|cytoplasm|cytosol|plasma membrane|photoreceptor cell morphogenesis|cell junction|ciliary base C8orf44-SGK3 76.3377033 65.97213794 86.70326866 1.314240699 0.394229524 0.602621755 1 0.73937952 1.013580528 100533105 C8orf44-SGK3 readthrough "GO:0001558,GO:0004672,GO:0004674,GO:0005246,GO:0005515,GO:0005524,GO:0005654,GO:0005769,GO:0005829,GO:0006468,GO:0015459,GO:0017080,GO:0017081,GO:0018105,GO:0030334,GO:0034220,GO:0035091,GO:0035556,GO:0042127,GO:0043231,GO:0051090,GO:0055037,GO:0106310,GO:0106311" regulation of cell growth|protein kinase activity|protein serine/threonine kinase activity|calcium channel regulator activity|protein binding|ATP binding|nucleoplasm|early endosome|cytosol|protein phosphorylation|potassium channel regulator activity|sodium channel regulator activity|chloride channel regulator activity|peptidyl-serine phosphorylation|regulation of cell migration|ion transmembrane transport|phosphatidylinositol binding|intracellular signal transduction|regulation of cell population proliferation|intracellular membrane-bounded organelle|regulation of DNA-binding transcription factor activity|recycling endosome|protein serine kinase activity|protein threonine kinase activity "hsa04068,hsa04151" FoxO signaling pathway|PI3K-Akt signaling pathway C8orf48 24.49527683 24.35894324 24.63161041 1.011193719 0.016059408 1 1 0.868798973 0.916367319 157773 chromosome 8 open reading frame 48 GO:0005515 protein binding C8orf58 365.3883541 495.2985126 235.4781956 0.475426818 -1.072704811 0.016701724 0.570200991 12.200935 6.050520246 541565 chromosome 8 open reading frame 58 C8orf76 39.03398906 41.6131947 36.45478341 0.876039047 -0.19093292 0.8596874 1 1.60882558 1.470105005 84933 chromosome 8 open reading frame 76 C8orf82 389.9417762 355.2345889 424.6489635 1.195404324 0.257498666 0.557715698 1 7.328463844 9.137843201 414919 chromosome 8 open reading frame 82 C8orf88 5.478337395 4.059823873 6.896850916 1.698805448 0.764520641 0.742562249 1 0.155181703 0.274979355 100127983 chromosome 8 open reading frame 88 "GO:0005737,GO:0008190,GO:0045947" cytoplasm|eukaryotic initiation factor 4E binding|negative regulation of translational initiation C9orf116 107.2938603 127.884452 86.70326866 0.677981313 -0.560682586 0.399427891 1 9.595401993 6.785733935 138162 chromosome 9 open reading frame 116 "GO:0005515,GO:0005634,GO:0006974,GO:0007368,GO:0010468,GO:0071494" protein binding|nucleus|cellular response to DNA damage stimulus|determination of left/right symmetry|regulation of gene expression|cellular response to UV-C C9orf163 28.40664294 22.3290313 34.48425458 1.544368589 0.627017117 0.544945573 1 0.369812513 0.595728656 158055 chromosome 9 putative open reading frame 163 C9orf24 10.00110192 10.14955968 9.852644165 0.970745971 -0.042834281 1 1 0.078611316 0.079598813 84688 chromosome 9 open reading frame 24 "GO:0002177,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007283,GO:0030154,GO:0034622,GO:0043014,GO:0048471" manchette|protein binding|nucleus|nucleoplasm|cytosol|spermatogenesis|cell differentiation|cellular protein-containing complex assembly|alpha-tubulin binding|perinuclear region of cytoplasm C9orf40 443.4875076 378.5785762 508.3964389 1.342908635 0.425361154 0.313330464 1 8.155537788 11.42391598 55071 chromosome 9 open reading frame 40 C9orf43 21.07654292 26.38885518 15.76423066 0.597382136 -0.743273999 0.51140799 1 0.517222299 0.322288939 257169 chromosome 9 open reading frame 43 GO:0005515 protein binding C9orf47 15.52397665 17.25425146 13.79370183 0.799437858 -0.3229422 0.834216248 1 0.180588338 0.150587992 286223 chromosome 9 open reading frame 47 GO:0005576 extracellular region C9orf64 511.3977612 541.9864871 480.8090353 0.887123658 -0.172792875 0.673295458 1 9.978081992 9.233091926 84267 chromosome 9 open reading frame 64 "GO:0003674,GO:0005515,GO:0005575,GO:0006400,GO:0008150,GO:0101030" molecular_function|protein binding|cellular_component|tRNA modification|biological_process|tRNA-guanine transglycosylation C9orf72 367.699098 350.1598091 385.2383869 1.100178767 0.137737964 0.761009756 1 3.897661328 4.472839233 203228 C9orf72-SMCR8 complex subunit "GO:0000932,GO:0001933,GO:0005085,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005776,GO:0005829,GO:0006897,GO:0006914,GO:0010494,GO:0010506,GO:0016239,GO:0030425,GO:0031267,GO:0031965,GO:0032045,GO:0034063,GO:0043204,GO:0043231,GO:0044295,GO:0044304,GO:0048675,GO:0050790,GO:0090543,GO:0110053,GO:1902774,GO:1903432,GO:1990316,GO:2000785" P-body|negative regulation of protein phosphorylation|guanyl-nucleotide exchange factor activity|protein binding|extracellular space|nucleus|cytoplasm|lysosome|endosome|autophagosome|cytosol|endocytosis|autophagy|cytoplasmic stress granule|regulation of autophagy|positive regulation of macroautophagy|dendrite|small GTPase binding|nuclear membrane|guanyl-nucleotide exchange factor complex|stress granule assembly|perikaryon|intracellular membrane-bounded organelle|axonal growth cone|main axon|axon extension|regulation of catalytic activity|Flemming body|regulation of actin filament organization|late endosome to lysosome transport|regulation of TORC1 signaling|Atg1/ULK1 kinase complex|regulation of autophagosome assembly "hsa04140,hsa05014,hsa05022" Autophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases C9orf78 1032.113719 1047.434559 1016.792878 0.970745971 -0.042834281 0.905417282 1 29.03605107 29.40079526 51759 chromosome 9 open reading frame 78 "GO:0005515,GO:0005654,GO:0005681,GO:0005829,GO:0048024" "protein binding|nucleoplasm|spliceosomal complex|cytosol|regulation of mRNA splicing, via spliceosome" C9orf85 272.5077588 275.0530674 269.9624501 0.981492236 -0.02695124 0.96411904 1 2.952621351 3.022807939 138241 chromosome 9 open reading frame 85 CA11 129.9873551 96.420817 163.5538931 1.696250854 0.762349542 0.220679629 1 2.84744853 5.038043251 770 carbonic anhydrase 11 "GO:0004089,GO:0005576,GO:0006730,GO:0008270,GO:0016323,GO:0016836" carbonate dehydratase activity|extracellular region|one-carbon metabolic process|zinc ion binding|basolateral plasma membrane|hydro-lyase activity CA12 86.95960621 152.2433953 21.67581716 0.142376076 -2.812221353 0.00023987 0.033175432 1.264445865 0.187781666 771 carbonic anhydrase 12 "GO:0004089,GO:0005886,GO:0006730,GO:0008270,GO:0015701,GO:0016021,GO:0016836,GO:0055064" carbonate dehydratase activity|plasma membrane|one-carbon metabolic process|zinc ion binding|bicarbonate transport|integral component of membrane|hydro-lyase activity|chloride ion homeostasis hsa00910 Nitrogen metabolism CA13 186.6967205 133.9741878 239.4192532 1.787055082 0.837584103 0.129497623 1 1.746992786 3.256454243 377677 carbonic anhydrase 13 "GO:0004089,GO:0005515,GO:0005737,GO:0005829,GO:0006730,GO:0008270,GO:0015701,GO:0016836,GO:0043209,GO:0043231" carbonate dehydratase activity|protein binding|cytoplasm|cytosol|one-carbon metabolic process|zinc ion binding|bicarbonate transport|hydro-lyase activity|myelin sheath|intracellular membrane-bounded organelle hsa00910 Nitrogen metabolism CA2 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.032909052 0.099967344 760 carbonic anhydrase 2 "GO:0001822,GO:0004064,GO:0004089,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0006730,GO:0008270,GO:0009268,GO:0010043,GO:0015670,GO:0015701,GO:0016323,GO:0016836,GO:0030424,GO:0032849,GO:0038166,GO:0042475,GO:0043627,GO:0044070,GO:0045177,GO:0045672,GO:0045780,GO:0048545,GO:0051453,GO:0070062,GO:0071498,GO:2001150" kidney development|arylesterase activity|carbonate dehydratase activity|protein binding|cytoplasm|cytosol|plasma membrane|microvillus|one-carbon metabolic process|zinc ion binding|response to pH|response to zinc ion|carbon dioxide transport|bicarbonate transport|basolateral plasma membrane|hydro-lyase activity|axon|positive regulation of cellular pH reduction|angiotensin-activated signaling pathway|odontogenesis of dentin-containing tooth|response to estrogen|regulation of anion transport|apical part of cell|positive regulation of osteoclast differentiation|positive regulation of bone resorption|response to steroid hormone|regulation of intracellular pH|extracellular exosome|cellular response to fluid shear stress|positive regulation of dipeptide transmembrane transport "hsa00910,hsa04964,hsa04966,hsa04971,hsa04972,hsa04976" Nitrogen metabolism|Proximal tubule bicarbonate reclamation|Collecting duct acid secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion CA3 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.089605937 0.151219244 761 carbonic anhydrase 3 "GO:0004089,GO:0005515,GO:0005829,GO:0006730,GO:0006979,GO:0008270,GO:0009617,GO:0015701,GO:0016151,GO:0016311,GO:0016791,GO:0016836,GO:0045471" carbonate dehydratase activity|protein binding|cytosol|one-carbon metabolic process|response to oxidative stress|zinc ion binding|response to bacterium|bicarbonate transport|nickel cation binding|dephosphorylation|phosphatase activity|hydro-lyase activity|response to ethanol hsa00910 Nitrogen metabolism CA5B 160.1957801 174.5724266 145.8191336 0.835293044 -0.25964567 0.660026985 1 1.293180862 1.126714967 11238 carbonic anhydrase 5B "GO:0004089,GO:0005737,GO:0005739,GO:0005759,GO:0006730,GO:0008270,GO:0009617,GO:0015701,GO:0016836" carbonate dehydratase activity|cytoplasm|mitochondrion|mitochondrial matrix|one-carbon metabolic process|zinc ion binding|response to bacterium|bicarbonate transport|hydro-lyase activity hsa00910 Nitrogen metabolism CA8 48.06195074 86.27125731 9.852644165 0.114205408 -3.130297123 0.000945026 0.087135285 0.453909707 0.054071955 767 carbonic anhydrase 8 "GO:0004089,GO:0005515,GO:0005737,GO:0006730,GO:0008270,GO:0016836,GO:0048015" carbonate dehydratase activity|protein binding|cytoplasm|one-carbon metabolic process|zinc ion binding|hydro-lyase activity|phosphatidylinositol-mediated signaling hsa00910 Nitrogen metabolism CA9 66.25692929 117.7348923 14.77896625 0.125527496 -2.993924681 0.000406205 0.047875616 3.856957925 0.505009674 768 carbonic anhydrase 9 "GO:0002009,GO:0004089,GO:0005515,GO:0005730,GO:0005886,GO:0006730,GO:0008270,GO:0015701,GO:0016021,GO:0016323,GO:0016836,GO:0031528,GO:0033574,GO:0042493,GO:0046903,GO:0061418" morphogenesis of an epithelium|carbonate dehydratase activity|protein binding|nucleolus|plasma membrane|one-carbon metabolic process|zinc ion binding|bicarbonate transport|integral component of membrane|basolateral plasma membrane|hydro-lyase activity|microvillus membrane|response to testosterone|response to drug|secretion|regulation of transcription from RNA polymerase II promoter in response to hypoxia hsa00910 Nitrogen metabolism CAAP1 580.6631859 562.2856065 599.0407653 1.065367419 0.091351066 0.820243791 1 9.6764466 10.7530396 79886 caspase activity and apoptosis inhibitor 1 "GO:0006915,GO:2001268" apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway CAB39 2231.277015 2064.42044 2398.13359 1.1616498 0.216175208 0.499903289 1 14.0626244 17.03952676 51719 calcium binding protein 39 "GO:0005515,GO:0005576,GO:0005829,GO:0007050,GO:0007165,GO:0010800,GO:0014823,GO:0016020,GO:0018105,GO:0019900,GO:0030018,GO:0030295,GO:0032147,GO:0034774,GO:0035556,GO:0043312,GO:0043539,GO:0070062,GO:0071476,GO:0071902,GO:0097066,GO:1901017,GO:1901380,GO:1902554,GO:1904813" protein binding|extracellular region|cytosol|cell cycle arrest|signal transduction|positive regulation of peptidyl-threonine phosphorylation|response to activity|membrane|peptidyl-serine phosphorylation|kinase binding|Z disc|protein kinase activator activity|activation of protein kinase activity|secretory granule lumen|intracellular signal transduction|neutrophil degranulation|protein serine/threonine kinase activator activity|extracellular exosome|cellular hypotonic response|positive regulation of protein serine/threonine kinase activity|response to thyroid hormone|negative regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transport|serine/threonine protein kinase complex|ficolin-1-rich granule lumen "hsa04150,hsa04152" mTOR signaling pathway|AMPK signaling pathway CAB39L 161.2134577 143.1087915 179.3181238 1.253019622 0.325409007 0.578149971 1 1.733545906 2.265735182 81617 calcium binding protein 39 like "GO:0005515,GO:0005829,GO:0007050,GO:0035556,GO:0043539,GO:0071902" protein binding|cytosol|cell cycle arrest|intracellular signal transduction|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity "hsa04150,hsa04152" mTOR signaling pathway|AMPK signaling pathway CABIN1 1929.343698 1630.019285 2228.66811 1.367264873 0.451292755 0.162790575 1 5.456359976 7.781648335 23523 calcineurin binding protein 1 "GO:0004864,GO:0005634,GO:0005654,GO:0005829,GO:0006336,GO:0007166,GO:0016235,GO:0031491,GO:0032515" protein phosphatase inhibitor activity|nucleus|nucleoplasm|cytosol|DNA replication-independent nucleosome assembly|cell surface receptor signaling pathway|aggresome|nucleosome binding|negative regulation of phosphoprotein phosphatase activity CABLES1 227.0344163 298.3970547 155.6717778 0.521693413 -0.938725878 0.070483417 1 2.738810826 1.490367319 91768 Cdk5 and Abl enzyme substrate 1 "GO:0005515,GO:0005634,GO:0005829,GO:0007049,GO:0051301,GO:0051726" protein binding|nucleus|cytosol|cell cycle|cell division|regulation of cell cycle CABLES2 470.1490299 382.6384001 557.6596598 1.457406417 0.543403248 0.190745477 1 5.120022483 7.783384322 81928 Cdk5 and Abl enzyme substrate 2 "GO:0007049,GO:0051301,GO:0051726" cell cycle|cell division|regulation of cell cycle CABP1 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.016831676 0.025564668 9478 calcium binding protein 1 "GO:0000139,GO:0004857,GO:0005509,GO:0005515,GO:0005615,GO:0005856,GO:0005886,GO:0005938,GO:0007601,GO:0008139,GO:0014069,GO:0042308,GO:0043086,GO:0048306,GO:0048471,GO:0050896" Golgi membrane|enzyme inhibitor activity|calcium ion binding|protein binding|extracellular space|cytoskeleton|plasma membrane|cell cortex|visual perception|nuclear localization sequence binding|postsynaptic density|negative regulation of protein import into nucleus|negative regulation of catalytic activity|calcium-dependent protein binding|perinuclear region of cytoplasm|response to stimulus CABYR 237.1921408 218.2155332 256.1687483 1.17392536 0.231340682 0.654495261 1 6.796953837 8.322824455 26256 calcium binding tyrosine phosphorylation regulated "GO:0003351,GO:0005509,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0017124,GO:0031514,GO:0035686,GO:0048240,GO:0097228,GO:0097229" epithelial cilium movement involved in extracellular fluid movement|calcium ion binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|SH3 domain binding|motile cilium|sperm fibrous sheath|sperm capacitation|sperm principal piece|sperm end piece CACFD1 228.3692983 221.2604011 235.4781956 1.064258197 0.089848202 0.869668921 1 2.377186838 2.638920158 11094 calcium channel flower domain containing 1 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021,GO:0016192" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane|vesicle-mediated transport CACHD1 516.0447351 489.2087768 542.8806935 1.10971168 0.150184891 0.71405112 1 3.797195206 4.395304935 57685 cache domain containing 1 "GO:0005245,GO:0005891,GO:0070588" voltage-gated calcium channel activity|voltage-gated calcium channel complex|calcium ion transmembrane transport CACNA1G 16.42016641 11.16451565 21.67581716 1.941491941 0.957165719 0.431505085 1 0.05248221 0.106282959 8913 calcium voltage-gated channel subunit alpha1 G "GO:0001518,GO:0005248,GO:0005737,GO:0005886,GO:0005891,GO:0007268,GO:0008332,GO:0010045,GO:0019228,GO:0034765,GO:0035725,GO:0042391,GO:0043005,GO:0045202,GO:0045956,GO:0060371,GO:0070509,GO:0070588,GO:0086002,GO:0086010,GO:0086015,GO:0086016,GO:0086018,GO:0086027,GO:0086045,GO:0086046,GO:0086056,GO:0086059,GO:0086091,GO:0097110" voltage-gated sodium channel complex|voltage-gated sodium channel activity|cytoplasm|plasma membrane|voltage-gated calcium channel complex|chemical synaptic transmission|low voltage-gated calcium channel activity|response to nickel cation|neuronal action potential|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|neuron projection|synapse|positive regulation of calcium ion-dependent exocytosis|regulation of atrial cardiac muscle cell membrane depolarization|calcium ion import|calcium ion transmembrane transport|cardiac muscle cell action potential involved in contraction|membrane depolarization during action potential|SA node cell action potential|AV node cell action potential|SA node cell to atrial cardiac muscle cell signaling|AV node cell to bundle of His cell signaling|membrane depolarization during AV node cell action potential|membrane depolarization during SA node cell action potential|voltage-gated calcium channel activity involved in AV node cell action potential|voltage-gated calcium channel activity involved SA node cell action potential|regulation of heart rate by cardiac conduction|scaffold protein binding "hsa04010,hsa04020,hsa04713,hsa04925,hsa04927,hsa04929,hsa04930,hsa04934" MAPK signaling pathway|Calcium signaling pathway|Circadian entrainment|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|GnRH secretion|Type II diabetes mellitus|Cushing syndrome CACNA1S 265.1882991 515.5976319 14.77896625 0.028663759 -5.124628372 1.87E-16 9.72E-13 4.329829404 0.129455307 779 calcium voltage-gated channel subunit alpha1 S "GO:0005245,GO:0005515,GO:0005516,GO:0005737,GO:0005886,GO:0005891,GO:0006816,GO:0006936,GO:0008331,GO:0030315,GO:0031674,GO:0034765,GO:0046872,GO:0061337,GO:0070509,GO:0070588,GO:0071313,GO:1990454" voltage-gated calcium channel activity|protein binding|calmodulin binding|cytoplasm|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|muscle contraction|high voltage-gated calcium channel activity|T-tubule|I band|regulation of ion transmembrane transport|metal ion binding|cardiac conduction|calcium ion import|calcium ion transmembrane transport|cellular response to caffeine|L-type voltage-gated calcium channel complex "hsa04010,hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04270,hsa04723,hsa04725,hsa04726,hsa04727,hsa04911,hsa04912,hsa04921,hsa04924,hsa04925,hsa04927,hsa04929,hsa04934,hsa04935,hsa05010,hsa05020,hsa05022,hsa05410,hsa05412,hsa05414" "MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Retrograde endocannabinoid signaling|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Insulin secretion|GnRH signaling pathway|Oxytocin signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy" CACNA2D1 293.1362068 304.4867905 281.7856231 0.925444492 -0.111781635 0.820417741 1 1.062723573 1.02585651 781 calcium voltage-gated channel auxiliary subunit alpha2delta 1 "GO:0005245,GO:0005886,GO:0005891,GO:0006816,GO:0016529,GO:0046872,GO:0051924,GO:0060307,GO:0060402,GO:0061337,GO:0061577,GO:0070062,GO:0086002,GO:0086007,GO:0086048,GO:0086057,GO:0086091,GO:0098703,GO:0098903,GO:1901843,GO:1902514,GO:1904646,GO:1990454" voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|sarcoplasmic reticulum|metal ion binding|regulation of calcium ion transport|regulation of ventricular cardiac muscle cell membrane repolarization|calcium ion transport into cytosol|cardiac conduction|calcium ion transmembrane transport via high voltage-gated calcium channel|extracellular exosome|cardiac muscle cell action potential involved in contraction|voltage-gated calcium channel activity involved in cardiac muscle cell action potential|membrane depolarization during bundle of His cell action potential|voltage-gated calcium channel activity involved in bundle of His cell action potential|regulation of heart rate by cardiac conduction|calcium ion import across plasma membrane|regulation of membrane repolarization during action potential|positive regulation of high voltage-gated calcium channel activity|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|cellular response to amyloid-beta|L-type voltage-gated calcium channel complex "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNA2D2 12.97174095 11.16451565 14.77896625 1.323744505 0.404624696 0.799654428 1 0.098629571 0.136184363 9254 calcium voltage-gated channel auxiliary subunit alpha2delta 2 "GO:0005245,GO:0005886,GO:0005891,GO:0034765,GO:0046872,GO:0050796,GO:0061337,GO:0070588" voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|regulation of ion transmembrane transport|metal ion binding|regulation of insulin secretion|cardiac conduction|calcium ion transmembrane transport "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNA2D3 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.09496637 0.05494818 55799 calcium voltage-gated channel auxiliary subunit alpha2delta 3 "GO:0005245,GO:0005886,GO:0005891,GO:0034765,GO:0046872,GO:0061337,GO:0070588" voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|regulation of ion transmembrane transport|metal ion binding|cardiac conduction|calcium ion transmembrane transport "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNA2D4 253.3045052 343.0551173 163.5538931 0.476756897 -1.068674286 0.033310203 0.820898508 1.840912425 0.91547406 93589 calcium voltage-gated channel auxiliary subunit alpha2delta 4 "GO:0005245,GO:0005886,GO:0005891,GO:0034765,GO:0046872,GO:0050908,GO:0061337,GO:0070588" voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|regulation of ion transmembrane transport|metal ion binding|detection of light stimulus involved in visual perception|cardiac conduction|calcium ion transmembrane transport "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNB1 236.803429 225.320225 248.286633 1.101927858 0.140029776 0.790176129 1 2.439434483 2.803872436 782 calcium voltage-gated channel auxiliary subunit beta 1 "GO:0005245,GO:0005515,GO:0005886,GO:0005891,GO:0007268,GO:0007528,GO:0008331,GO:0042383,GO:0045202,GO:0061337,GO:0070588,GO:1901385,GO:1902514,GO:1904646" voltage-gated calcium channel activity|protein binding|plasma membrane|voltage-gated calcium channel complex|chemical synaptic transmission|neuromuscular junction development|high voltage-gated calcium channel activity|sarcolemma|synapse|cardiac conduction|calcium ion transmembrane transport|regulation of voltage-gated calcium channel activity|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|cellular response to amyloid-beta "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNB3 1110.385578 1009.881189 1210.889968 1.199042008 0.261882204 0.449934862 1 8.835190802 11.05010135 784 calcium voltage-gated channel auxiliary subunit beta 3 "GO:0005245,GO:0005246,GO:0005515,GO:0005829,GO:0005886,GO:0005891,GO:0006816,GO:0007268,GO:0007528,GO:0008331,GO:0016020,GO:0016324,GO:0019901,GO:0045202,GO:0050852,GO:0050966,GO:0051899,GO:0060402,GO:0061337,GO:0061577,GO:0072659,GO:0090314,GO:0090650,GO:0098903,GO:1901385,GO:1901386,GO:1901843,GO:1902630,GO:1905788,GO:1990454,GO:2000463" voltage-gated calcium channel activity|calcium channel regulator activity|protein binding|cytosol|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|chemical synaptic transmission|neuromuscular junction development|high voltage-gated calcium channel activity|membrane|apical plasma membrane|protein kinase binding|synapse|T cell receptor signaling pathway|detection of mechanical stimulus involved in sensory perception of pain|membrane depolarization|calcium ion transport into cytosol|cardiac conduction|calcium ion transmembrane transport via high voltage-gated calcium channel|protein localization to plasma membrane|positive regulation of protein targeting to membrane|cellular response to oxygen-glucose deprivation|regulation of membrane repolarization during action potential|regulation of voltage-gated calcium channel activity|negative regulation of voltage-gated calcium channel activity|positive regulation of high voltage-gated calcium channel activity|regulation of membrane hyperpolarization|negative regulation of detection of mechanical stimulus involved in sensory perception of touch|L-type voltage-gated calcium channel complex|positive regulation of excitatory postsynaptic potential "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNB4 23.92841574 19.2841634 28.57266808 1.481664902 0.5672192 0.609483674 1 0.048491875 0.07494366 785 calcium voltage-gated channel auxiliary subunit beta 4 "GO:0005245,GO:0005515,GO:0005829,GO:0005886,GO:0005891,GO:0007268,GO:0007528,GO:0008331,GO:0009898,GO:0045202,GO:0051899,GO:0061337,GO:0070588,GO:1901385" voltage-gated calcium channel activity|protein binding|cytosol|plasma membrane|voltage-gated calcium channel complex|chemical synaptic transmission|neuromuscular junction development|high voltage-gated calcium channel activity|cytoplasmic side of plasma membrane|synapse|membrane depolarization|cardiac conduction|calcium ion transmembrane transport|regulation of voltage-gated calcium channel activity "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNG6 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.05396739 0.109290632 59285 calcium voltage-gated channel auxiliary subunit gamma 6 "GO:0005245,GO:0005246,GO:0005886,GO:0005891,GO:0006816,GO:0061337,GO:0070588,GO:1902514,GO:1990454" voltage-gated calcium channel activity|calcium channel regulator activity|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|cardiac conduction|calcium ion transmembrane transport|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|L-type voltage-gated calcium channel complex "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNG7 134.5964727 142.0938356 127.0991097 0.894473073 -0.160890043 0.802977377 1 2.613126904 2.438056143 59284 calcium voltage-gated channel auxiliary subunit gamma 7 "GO:0005245,GO:0005246,GO:0005515,GO:0005769,GO:0005886,GO:0005891,GO:0006816,GO:0016247,GO:0019226,GO:0032281,GO:0043025,GO:0043488,GO:0044300,GO:0051968,GO:0061337,GO:0070588,GO:0098839,GO:0098943,GO:0098970,GO:0098978,GO:0099061,GO:0099590,GO:1903861,GO:1990454,GO:2000311" "voltage-gated calcium channel activity|calcium channel regulator activity|protein binding|early endosome|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|channel regulator activity|transmission of nerve impulse|AMPA glutamate receptor complex|neuronal cell body|regulation of mRNA stability|cerebellar mossy fiber|positive regulation of synaptic transmission, glutamatergic|cardiac conduction|calcium ion transmembrane transport|postsynaptic density membrane|neurotransmitter receptor transport, postsynaptic endosome to lysosome|postsynaptic neurotransmitter receptor diffusion trapping|glutamatergic synapse|integral component of postsynaptic density membrane|neurotransmitter receptor internalization|positive regulation of dendrite extension|L-type voltage-gated calcium channel complex|regulation of AMPA receptor activity" "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNG8 10.59765456 17.25425146 3.941057666 0.228410817 -2.130297123 0.136104822 1 0.09874203 0.023525272 59283 calcium voltage-gated channel auxiliary subunit gamma 8 "GO:0005245,GO:0005246,GO:0005886,GO:0005891,GO:0006816,GO:0014069,GO:0016247,GO:0019226,GO:0030666,GO:0032281,GO:0051968,GO:0061337,GO:0070588,GO:0098839,GO:0098943,GO:0098970,GO:0099590,GO:1990454,GO:2000311" "voltage-gated calcium channel activity|calcium channel regulator activity|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|postsynaptic density|channel regulator activity|transmission of nerve impulse|endocytic vesicle membrane|AMPA glutamate receptor complex|positive regulation of synaptic transmission, glutamatergic|cardiac conduction|calcium ion transmembrane transport|postsynaptic density membrane|neurotransmitter receptor transport, postsynaptic endosome to lysosome|postsynaptic neurotransmitter receptor diffusion trapping|neurotransmitter receptor internalization|L-type voltage-gated calcium channel complex|regulation of AMPA receptor activity" "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACTIN 680.1194682 693.2149264 667.02401 0.962218187 -0.055564026 0.887427369 1 8.161062414 8.19098613 58509 "cactin, spliceosome C complex subunit" "GO:0000398,GO:0001933,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0005829,GO:0007275,GO:0010468,GO:0016607,GO:0031665,GO:0032088,GO:0032688,GO:0032717,GO:0032720,GO:0034122,GO:0043124,GO:0045087,GO:0045292,GO:0045824,GO:0060339,GO:0071013,GO:0071222,GO:0071347,GO:0071356" "mRNA splicing, via spliceosome|negative regulation of protein phosphorylation|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|cytosol|multicellular organism development|regulation of gene expression|nuclear speck|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-beta production|negative regulation of interleukin-8 production|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|mRNA cis splicing, via spliceosome|negative regulation of innate immune response|negative regulation of type I interferon-mediated signaling pathway|catalytic step 2 spliceosome|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor" CACUL1 1316.791546 1278.84452 1354.738573 1.059345801 0.083173604 0.807000463 1 5.869412184 6.485572052 143384 CDK2 associated cullin domain 1 "GO:0000082,GO:0005515,GO:0006511,GO:0008284,GO:0019901,GO:0031625,GO:0045860" G1/S transition of mitotic cell cycle|protein binding|ubiquitin-dependent protein catabolic process|positive regulation of cell population proliferation|protein kinase binding|ubiquitin protein ligase binding|positive regulation of protein kinase activity CACYBP 2038.489075 2120.243018 1956.735131 0.922882478 -0.115781151 0.719895062 1 46.99467356 45.23878867 27101 calcyclin binding protein "GO:0005515,GO:0005634,GO:0005641,GO:0005654,GO:0005829,GO:0007507,GO:0007568,GO:0015631,GO:0019005,GO:0019904,GO:0030877,GO:0031625,GO:0042803,GO:0043005,GO:0044297,GO:0044548,GO:0045740,GO:0055007,GO:0060416,GO:0060548,GO:0070062,GO:0071277,GO:1990830" protein binding|nucleus|nuclear envelope lumen|nucleoplasm|cytosol|heart development|aging|tubulin binding|SCF ubiquitin ligase complex|protein domain specific binding|beta-catenin destruction complex|ubiquitin protein ligase binding|protein homodimerization activity|neuron projection|cell body|S100 protein binding|positive regulation of DNA replication|cardiac muscle cell differentiation|response to growth hormone|negative regulation of cell death|extracellular exosome|cellular response to calcium ion|cellular response to leukemia inhibitory factor hsa04310 Wnt signaling pathway CAD 2453.753532 2421.684941 2485.822123 1.026484528 0.037711882 0.907168541 1 16.59447964 17.76773123 790 "carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase" "GO:0001889,GO:0004070,GO:0004088,GO:0004151,GO:0004672,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006207,GO:0006228,GO:0006541,GO:0006807,GO:0007507,GO:0007565,GO:0007595,GO:0008270,GO:0014075,GO:0016020,GO:0016363,GO:0017144,GO:0018107,GO:0019240,GO:0019899,GO:0031000,GO:0031100,GO:0032868,GO:0032991,GO:0033574,GO:0035690,GO:0042594,GO:0042802,GO:0042995,GO:0043025,GO:0043195,GO:0044205,GO:0046134,GO:0046777,GO:0051414,GO:0070062,GO:0070335,GO:0071364" liver development|aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|protein kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|'de novo' pyrimidine nucleobase biosynthetic process|UTP biosynthetic process|glutamine metabolic process|nitrogen compound metabolic process|heart development|female pregnancy|lactation|zinc ion binding|response to amine|membrane|nuclear matrix|drug metabolic process|peptidyl-threonine phosphorylation|citrulline biosynthetic process|enzyme binding|response to caffeine|animal organ regeneration|response to insulin|protein-containing complex|response to testosterone|cellular response to drug|response to starvation|identical protein binding|cell projection|neuronal cell body|terminal bouton|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process|protein autophosphorylation|response to cortisol|extracellular exosome|aspartate binding|cellular response to epidermal growth factor stimulus "hsa00240,hsa00250" "Pyrimidine metabolism|Alanine, aspartate and glutamate metabolism" CADM4 337.5027971 306.5167024 368.4888918 1.202182096 0.265655439 0.562586921 1 7.114569044 8.921436401 199731 cell adhesion molecule 4 "GO:0001932,GO:0001933,GO:0007155,GO:0010801,GO:0016021,GO:0019903,GO:0030948,GO:0030971,GO:0031252,GO:0035020,GO:0042127,GO:0043183,GO:0043184,GO:0044291,GO:0050732,GO:0061041,GO:1900747,GO:2000145" regulation of protein phosphorylation|negative regulation of protein phosphorylation|cell adhesion|negative regulation of peptidyl-threonine phosphorylation|integral component of membrane|protein phosphatase binding|negative regulation of vascular endothelial growth factor receptor signaling pathway|receptor tyrosine kinase binding|cell leading edge|regulation of Rac protein signal transduction|regulation of cell population proliferation|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|cell-cell contact zone|negative regulation of peptidyl-tyrosine phosphorylation|regulation of wound healing|negative regulation of vascular endothelial growth factor signaling pathway|regulation of cell motility CADPS2 104.2220225 86.27125731 122.1727877 1.416147063 0.501971093 0.456214648 1 0.792551213 1.17071618 93664 calcium dependent secretion activator 2 "GO:0005654,GO:0006887,GO:0008289,GO:0015031,GO:0016079,GO:0030659,GO:0043231,GO:0045921,GO:0046872,GO:0098793,GO:0098978,GO:1990504" nucleoplasm|exocytosis|lipid binding|protein transport|synaptic vesicle exocytosis|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle|positive regulation of exocytosis|metal ion binding|presynapse|glutamatergic synapse|dense core granule exocytosis CALCOCO1 1197.429062 864.7424851 1530.115639 1.769446587 0.823298213 0.016592291 0.569346602 7.525112756 13.88885356 57658 calcium binding and coiled-coil domain 1 "GO:0000976,GO:0000978,GO:0003682,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005829,GO:0007165,GO:0008013,GO:0008022,GO:0010628,GO:0016055,GO:0030374,GO:0030518,GO:0043231,GO:0043565,GO:0045893,GO:0045944,GO:0046872,GO:0070016" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|cytosol|signal transduction|beta-catenin binding|protein C-terminus binding|positive regulation of gene expression|Wnt signaling pathway|nuclear receptor coactivator activity|intracellular steroid hormone receptor signaling pathway|intracellular membrane-bounded organelle|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|armadillo repeat domain binding" CALCOCO2 1832.038815 1477.77589 2186.30174 1.479454195 0.565065031 0.082100985 1 19.85255585 30.63612832 10241 calcium binding and coiled-coil domain 2 "GO:0000421,GO:0005515,GO:0005634,GO:0005737,GO:0005776,GO:0005829,GO:0005856,GO:0016020,GO:0016032,GO:0016605,GO:0031410,GO:0034341,GO:0042803,GO:0043231,GO:0046872,GO:0048471,GO:0098792,GO:1901098" autophagosome membrane|protein binding|nucleus|cytoplasm|autophagosome|cytosol|cytoskeleton|membrane|viral process|PML body|cytoplasmic vesicle|response to interferon-gamma|protein homodimerization activity|intracellular membrane-bounded organelle|metal ion binding|perinuclear region of cytoplasm|xenophagy|positive regulation of autophagosome maturation "hsa04137,hsa05131,hsa05164" Mitophagy - animal|Shigellosis|Influenza A CALCR 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.025824637 0.03922356 799 calcitonin receptor "GO:0001540,GO:0001635,GO:0004948,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007188,GO:0007189,GO:0007190,GO:0007204,GO:0008528,GO:0010628,GO:0010739,GO:0010942,GO:0030424,GO:0032841,GO:0033138,GO:0038041,GO:0051384,GO:0051897,GO:0070374,GO:0097643,GO:0097647,GO:0150056,GO:0150057,GO:0150058,GO:1904645,GO:1905665" amyloid-beta binding|calcitonin gene-related peptide receptor activity|calcitonin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|positive regulation of cytosolic calcium ion concentration|G protein-coupled peptide receptor activity|positive regulation of gene expression|positive regulation of protein kinase A signaling|positive regulation of cell death|axon|calcitonin binding|positive regulation of peptidyl-serine phosphorylation|cross-receptor inhibition within G protein-coupled receptor heterodimer|response to glucocorticoid|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|amylin receptor activity|amylin receptor signaling pathway|amylin receptor complex 1|amylin receptor complex 2|amylin receptor complex 3|response to amyloid-beta|positive regulation of calcium ion import across plasma membrane "hsa04080,hsa04380" Neuroactive ligand-receptor interaction|Osteoclast differentiation CALCRL 18.9724021 17.25425146 20.69055275 1.199156787 0.2620203 0.858856573 1 0.14006523 0.175195214 10203 calcitonin receptor like receptor "GO:0001525,GO:0001605,GO:0001635,GO:0004930,GO:0004948,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005783,GO:0005886,GO:0005887,GO:0006816,GO:0007166,GO:0007186,GO:0007187,GO:0007188,GO:0007189,GO:0007507,GO:0008528,GO:0015031,GO:0031623,GO:0045986,GO:0048661,GO:0050728,GO:0071329,GO:1903143,GO:1990406,GO:1990408,GO:1990409,GO:1990410" "angiogenesis|adrenomedullin receptor activity|calcitonin gene-related peptide receptor activity|G protein-coupled receptor activity|calcitonin receptor activity|protein binding|cytoplasm|lysosome|endosome|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|calcium ion transport|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|heart development|G protein-coupled peptide receptor activity|protein transport|receptor internalization|negative regulation of smooth muscle contraction|positive regulation of smooth muscle cell proliferation|negative regulation of inflammatory response|cellular response to sucrose stimulus|adrenomedullin receptor complex|CGRP receptor complex|calcitonin gene-related peptide receptor signaling pathway|adrenomedullin binding|adrenomedullin receptor signaling pathway" "hsa04080,hsa04270" Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction CALD1 1712.900009 1617.839814 1807.960204 1.117514966 0.160294152 0.624285083 1 17.23919191 20.0949154 800 caldesmon 1 "GO:0003779,GO:0005515,GO:0005516,GO:0005523,GO:0005829,GO:0005856,GO:0005886,GO:0006936,GO:0015629,GO:0017022,GO:0030016,GO:0030478,GO:0045296" actin binding|protein binding|calmodulin binding|tropomyosin binding|cytosol|cytoskeleton|plasma membrane|muscle contraction|actin cytoskeleton|myosin binding|myofibril|actin cap|cadherin binding hsa04270 Vascular smooth muscle contraction CALHM2 1315.899562 1049.464471 1582.334653 1.50775438 0.592401426 0.079574702 1 20.30239617 31.92962564 51063 calcium homeostasis modulator family member 2 "GO:0005261,GO:0005887,GO:0043065,GO:0098655" cation channel activity|integral component of plasma membrane|positive regulation of apoptotic process|cation transmembrane transport CALHM5 117.4285742 147.1686154 87.68853307 0.595837182 -0.74700994 0.245855384 1 0.761578746 0.473323804 254228 calcium homeostasis modulator family member 5 "GO:0005261,GO:0005887,GO:0098655" cation channel activity|integral component of plasma membrane|cation transmembrane transport CALM1 9919.188398 10544.37756 9293.999241 0.881417532 -0.182102502 0.588143579 1 101.1239396 92.97187611 801 calmodulin 1 "GO:0000086,GO:0000165,GO:0000922,GO:0001975,GO:0002027,GO:0002576,GO:0005509,GO:0005513,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005876,GO:0005886,GO:0005980,GO:0006936,GO:0007186,GO:0007190,GO:0007223,GO:0008076,GO:0008179,GO:0010800,GO:0010801,GO:0010856,GO:0010880,GO:0010881,GO:0016032,GO:0019855,GO:0019901,GO:0019904,GO:0021762,GO:0022400,GO:0030017,GO:0030234,GO:0030235,GO:0030426,GO:0030672,GO:0031432,GO:0031800,GO:0031954,GO:0031966,GO:0031982,GO:0031997,GO:0032465,GO:0032516,GO:0032991,GO:0034704,GO:0035307,GO:0038095,GO:0043209,GO:0043388,GO:0043539,GO:0043548,GO:0043647,GO:0044325,GO:0048306,GO:0050998,GO:0050999,GO:0051000,GO:0051343,GO:0051412,GO:0051592,GO:0055117,GO:0060314,GO:0060315,GO:0060316,GO:0071902,GO:0072542,GO:0090151,GO:0097718,GO:0098901,GO:1900242,GO:1901842,GO:1901844,GO:1902494,GO:2000300" "G2/M transition of mitotic cell cycle|MAPK cascade|spindle pole|response to amphetamine|regulation of heart rate|platelet degranulation|calcium ion binding|detection of calcium ion|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|spindle microtubule|plasma membrane|glycogen catabolic process|muscle contraction|G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|Wnt signaling pathway, calcium modulating pathway|voltage-gated potassium channel complex|adenylate cyclase binding|positive regulation of peptidyl-threonine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|adenylate cyclase activator activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|viral process|calcium channel inhibitor activity|protein kinase binding|protein domain specific binding|substantia nigra development|regulation of rhodopsin mediated signaling pathway|sarcomere|enzyme regulator activity|nitric-oxide synthase regulator activity|growth cone|synaptic vesicle membrane|titin binding|type 3 metabotropic glutamate receptor binding|positive regulation of protein autophosphorylation|mitochondrial membrane|vesicle|N-terminal myristoylation domain binding|regulation of cytokinesis|positive regulation of phosphoprotein phosphatase activity|protein-containing complex|calcium channel complex|positive regulation of protein dephosphorylation|Fc-epsilon receptor signaling pathway|myelin sheath|positive regulation of DNA binding|protein serine/threonine kinase activator activity|phosphatidylinositol 3-kinase binding|inositol phosphate metabolic process|ion channel binding|calcium-dependent protein binding|nitric-oxide synthase binding|regulation of nitric-oxide synthase activity|positive regulation of nitric-oxide synthase activity|positive regulation of cyclic-nucleotide phosphodiesterase activity|response to corticosterone|response to calcium ion|regulation of cardiac muscle contraction|regulation of ryanodine-sensitive calcium-release channel activity|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of protein serine/threonine kinase activity|protein phosphatase activator activity|establishment of protein localization to mitochondrial membrane|disordered domain specific binding|regulation of cardiac muscle cell action potential|regulation of synaptic vesicle endocytosis|negative regulation of high voltage-gated calcium channel activity|regulation of cell communication by electrical coupling involved in cardiac conduction|catalytic complex|regulation of synaptic vesicle exocytosis" "hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05012,hsa05022,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418" Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALM2 6269.063561 5814.682743 6723.444379 1.156287398 0.209500028 0.519551614 1 218.7913581 263.8832876 805 calmodulin 2 "GO:0000922,GO:0002027,GO:0005509,GO:0005513,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005876,GO:0005886,GO:0007186,GO:0008179,GO:0010800,GO:0010801,GO:0010856,GO:0010880,GO:0010881,GO:0019855,GO:0019901,GO:0019904,GO:0021762,GO:0030017,GO:0030234,GO:0031432,GO:0031954,GO:0031982,GO:0031997,GO:0032465,GO:0032516,GO:0032991,GO:0034704,GO:0035307,GO:0043539,GO:0044325,GO:0051343,GO:0051592,GO:0055117,GO:0060314,GO:0060315,GO:0060316,GO:0071902,GO:0072542,GO:0097718,GO:1901844,GO:1902494" spindle pole|regulation of heart rate|calcium ion binding|detection of calcium ion|protein binding|nucleus|cytoplasm|centrosome|spindle microtubule|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase binding|positive regulation of peptidyl-threonine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|adenylate cyclase activator activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|calcium channel inhibitor activity|protein kinase binding|protein domain specific binding|substantia nigra development|sarcomere|enzyme regulator activity|titin binding|positive regulation of protein autophosphorylation|vesicle|N-terminal myristoylation domain binding|regulation of cytokinesis|positive regulation of phosphoprotein phosphatase activity|protein-containing complex|calcium channel complex|positive regulation of protein dephosphorylation|protein serine/threonine kinase activator activity|ion channel binding|positive regulation of cyclic-nucleotide phosphodiesterase activity|response to calcium ion|regulation of cardiac muscle contraction|regulation of ryanodine-sensitive calcium-release channel activity|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of protein serine/threonine kinase activity|protein phosphatase activator activity|disordered domain specific binding|regulation of cell communication by electrical coupling involved in cardiac conduction|catalytic complex "hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05012,hsa05022,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418" Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALM3 6151.827489 6421.626412 5882.028567 0.915971779 -0.126624946 0.696872756 1 131.5666358 125.7024645 808 calmodulin 3 "GO:0000086,GO:0000922,GO:0001975,GO:0002027,GO:0005509,GO:0005513,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005876,GO:0005886,GO:0007186,GO:0007190,GO:0008076,GO:0008179,GO:0010800,GO:0010801,GO:0010856,GO:0010880,GO:0010881,GO:0019901,GO:0019904,GO:0021762,GO:0030017,GO:0030234,GO:0030235,GO:0030426,GO:0030672,GO:0031432,GO:0031800,GO:0031954,GO:0031966,GO:0031982,GO:0031997,GO:0032465,GO:0032516,GO:0032991,GO:0034704,GO:0035307,GO:0043209,GO:0043388,GO:0043539,GO:0043548,GO:0044325,GO:0048306,GO:0050998,GO:0051000,GO:0051343,GO:0051412,GO:0051592,GO:0055117,GO:0060315,GO:0060316,GO:0071902,GO:0072542,GO:0090151,GO:0097718,GO:0098901,GO:1900242,GO:1901842,GO:1901844,GO:1902494,GO:2000300" G2/M transition of mitotic cell cycle|spindle pole|response to amphetamine|regulation of heart rate|calcium ion binding|detection of calcium ion|protein binding|nucleus|cytoplasm|centrosome|spindle microtubule|plasma membrane|G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|voltage-gated potassium channel complex|adenylate cyclase binding|positive regulation of peptidyl-threonine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|adenylate cyclase activator activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|protein kinase binding|protein domain specific binding|substantia nigra development|sarcomere|enzyme regulator activity|nitric-oxide synthase regulator activity|growth cone|synaptic vesicle membrane|titin binding|type 3 metabotropic glutamate receptor binding|positive regulation of protein autophosphorylation|mitochondrial membrane|vesicle|N-terminal myristoylation domain binding|regulation of cytokinesis|positive regulation of phosphoprotein phosphatase activity|protein-containing complex|calcium channel complex|positive regulation of protein dephosphorylation|myelin sheath|positive regulation of DNA binding|protein serine/threonine kinase activator activity|phosphatidylinositol 3-kinase binding|ion channel binding|calcium-dependent protein binding|nitric-oxide synthase binding|positive regulation of nitric-oxide synthase activity|positive regulation of cyclic-nucleotide phosphodiesterase activity|response to corticosterone|response to calcium ion|regulation of cardiac muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of protein serine/threonine kinase activity|protein phosphatase activator activity|establishment of protein localization to mitochondrial membrane|disordered domain specific binding|regulation of cardiac muscle cell action potential|regulation of synaptic vesicle endocytosis|negative regulation of high voltage-gated calcium channel activity|regulation of cell communication by electrical coupling involved in cardiac conduction|catalytic complex|regulation of synaptic vesicle exocytosis "hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05012,hsa05022,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418" Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALML4 67.64847286 78.15160956 57.14533616 0.731211251 -0.451639827 0.56512937 1 1.026212943 0.78270171 91860 calmodulin like 4 "GO:0005509,GO:0030234,GO:0050790" calcium ion binding|enzyme regulator activity|regulation of catalytic activity "hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05012,hsa05022,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418" Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALML6 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.09158831 0.069554116 163688 calmodulin like 6 "GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0030234,GO:0050790" calcium ion binding|protein binding|nucleus|cytoplasm|enzyme regulator activity|regulation of catalytic activity "hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05012,hsa05022,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418" Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALR 20543.72145 20172.24987 20915.19303 1.03682996 0.052179312 0.886454503 1 537.4294017 581.2258081 811 calreticulin "GO:0000122,GO:0001669,GO:0001849,GO:0002474,GO:0002479,GO:0002502,GO:0003677,GO:0003723,GO:0003729,GO:0005178,GO:0005506,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005635,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0005790,GO:0005794,GO:0005829,GO:0005844,GO:0005925,GO:0006355,GO:0006457,GO:0006611,GO:0006874,GO:0006898,GO:0007283,GO:0008270,GO:0008284,GO:0009897,GO:0009986,GO:0010595,GO:0010628,GO:0016020,GO:0017148,GO:0022417,GO:0030246,GO:0030670,GO:0030866,GO:0030968,GO:0031625,GO:0032355,GO:0033018,GO:0033116,GO:0033144,GO:0033574,GO:0034504,GO:0034975,GO:0036500,GO:0040020,GO:0042277,GO:0042493,GO:0042562,GO:0042824,GO:0042921,GO:0042981,GO:0044183,GO:0044322,GO:0045665,GO:0045787,GO:0045892,GO:0048387,GO:0048471,GO:0050681,GO:0050766,GO:0050821,GO:0051082,GO:0051087,GO:0051208,GO:0055007,GO:0062023,GO:0070062,GO:0071157,GO:0071285,GO:0071556,GO:0071682,GO:0090398,GO:1900026,GO:1901164,GO:1901224,GO:1990668,GO:2000510" "negative regulation of transcription by RNA polymerase II|acrosomal vesicle|complement component C1q complex binding|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|peptide antigen assembly with MHC class I protein complex|DNA binding|RNA binding|mRNA binding|integrin binding|iron ion binding|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|smooth endoplasmic reticulum|Golgi apparatus|cytosol|polysome|focal adhesion|regulation of transcription, DNA-templated|protein folding|protein export from nucleus|cellular calcium ion homeostasis|receptor-mediated endocytosis|spermatogenesis|zinc ion binding|positive regulation of cell population proliferation|external side of plasma membrane|cell surface|positive regulation of endothelial cell migration|positive regulation of gene expression|membrane|negative regulation of translation|protein maturation by protein folding|carbohydrate binding|phagocytic vesicle membrane|cortical actin cytoskeleton organization|endoplasmic reticulum unfolded protein response|ubiquitin protein ligase binding|response to estradiol|sarcoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment membrane|negative regulation of intracellular steroid hormone receptor signaling pathway|response to testosterone|protein localization to nucleus|protein folding in endoplasmic reticulum|ATF6-mediated unfolded protein response|regulation of meiotic nuclear division|peptide binding|response to drug|hormone binding|MHC class I peptide loading complex|glucocorticoid receptor signaling pathway|regulation of apoptotic process|protein folding chaperone|endoplasmic reticulum quality control compartment|negative regulation of neuron differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|negative regulation of retinoic acid receptor signaling pathway|perinuclear region of cytoplasm|androgen receptor binding|positive regulation of phagocytosis|protein stabilization|unfolded protein binding|chaperone binding|sequestering of calcium ion|cardiac muscle cell differentiation|collagen-containing extracellular matrix|extracellular exosome|negative regulation of cell cycle arrest|cellular response to lithium ion|integral component of lumenal side of endoplasmic reticulum membrane|endocytic vesicle lumen|cellular senescence|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of trophoblast cell migration|positive regulation of NIK/NF-kappaB signaling|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane|positive regulation of dendritic cell chemotaxis" "hsa04141,hsa04145,hsa04612,hsa05142,hsa05163,hsa05166,hsa05168,hsa05169,hsa05170" Protein processing in endoplasmic reticulum|Phagosome|Antigen processing and presentation|Chagas disease|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection CALU 13486.37386 13780.05718 13192.69054 0.957375602 -0.062843055 0.856116629 1 134.9664056 134.7795392 813 calumenin "GO:0005509,GO:0005515,GO:0005576,GO:0005783,GO:0005788,GO:0005789,GO:0005794,GO:0008150,GO:0016020,GO:0033018,GO:0042470,GO:0043687,GO:0044267" calcium ion binding|protein binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi apparatus|biological_process|membrane|sarcoplasmic reticulum lumen|melanosome|post-translational protein modification|cellular protein metabolic process CAMK1 855.9419076 723.6636055 988.2202098 1.365579535 0.449513343 0.215183534 1 22.19927843 31.62072241 8536 calcium/calmodulin dependent protein kinase I "GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005622,GO:0005634,GO:0005829,GO:0006468,GO:0006913,GO:0007049,GO:0007165,GO:0007399,GO:0010976,GO:0014069,GO:0018105,GO:0030154,GO:0032091,GO:0032880,GO:0033138,GO:0043393,GO:0045944,GO:0046827,GO:0051147,GO:0051149,GO:0051835,GO:0060143,GO:0060999,GO:0071902,GO:0098978,GO:1901985,GO:2000615" calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|intracellular anatomical structure|nucleus|cytosol|protein phosphorylation|nucleocytoplasmic transport|cell cycle|signal transduction|nervous system development|positive regulation of neuron projection development|postsynaptic density|peptidyl-serine phosphorylation|cell differentiation|negative regulation of protein binding|regulation of protein localization|positive regulation of peptidyl-serine phosphorylation|regulation of protein binding|positive regulation of transcription by RNA polymerase II|positive regulation of protein export from nucleus|regulation of muscle cell differentiation|positive regulation of muscle cell differentiation|positive regulation of synapse structural plasticity|positive regulation of syncytium formation by plasma membrane fusion|positive regulation of dendritic spine development|positive regulation of protein serine/threonine kinase activity|glutamatergic synapse|positive regulation of protein acetylation|regulation of histone H3-K9 acetylation "hsa04020,hsa04921,hsa04925,hsa05214" Calcium signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Glioma CAMK1G 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.020836619 0.105491819 57172 calcium/calmodulin dependent protein kinase IG "GO:0000139,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005622,GO:0005886,GO:0005954,GO:0018105,GO:0043005" Golgi membrane|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|intracellular anatomical structure|plasma membrane|calcium- and calmodulin-dependent protein kinase complex|peptidyl-serine phosphorylation|neuron projection "hsa04020,hsa04921,hsa04925,hsa05214" Calcium signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Glioma CAMK2D 484.7295579 436.4310664 533.0280494 1.221333884 0.288457653 0.48495556 1 3.226345625 4.110183632 817 calcium/calmodulin dependent protein kinase II delta "GO:0001558,GO:0002026,GO:0003254,GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005954,GO:0006357,GO:0006468,GO:0008016,GO:0010613,GO:0010649,GO:0010666,GO:0010880,GO:0010881,GO:0016020,GO:0018105,GO:0018107,GO:0019871,GO:0030666,GO:0031432,GO:0032469,GO:0033017,GO:0042383,GO:0042802,GO:0042803,GO:0043005,GO:0044325,GO:0046777,GO:0055119,GO:0060314,GO:0060333,GO:0060341,GO:0071277,GO:0086003,GO:0086091,GO:0098901,GO:0098909,GO:1900034,GO:1901725,GO:1901844,GO:1901897,GO:1902306,GO:1902514,GO:2000650" regulation of cell growth|regulation of the force of heart contraction|regulation of membrane depolarization|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|calcium- and calmodulin-dependent protein kinase complex|regulation of transcription by RNA polymerase II|protein phosphorylation|regulation of heart contraction|positive regulation of cardiac muscle hypertrophy|regulation of cell communication by electrical coupling|positive regulation of cardiac muscle cell apoptotic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sodium channel inhibitor activity|endocytic vesicle membrane|titin binding|endoplasmic reticulum calcium ion homeostasis|sarcoplasmic reticulum membrane|sarcolemma|identical protein binding|protein homodimerization activity|neuron projection|ion channel binding|protein autophosphorylation|relaxation of cardiac muscle|regulation of ryanodine-sensitive calcium-release channel activity|interferon-gamma-mediated signaling pathway|regulation of cellular localization|cellular response to calcium ion|cardiac muscle cell contraction|regulation of heart rate by cardiac conduction|regulation of cardiac muscle cell action potential|regulation of cardiac muscle cell action potential involved in regulation of contraction|regulation of cellular response to heat|regulation of histone deacetylase activity|regulation of cell communication by electrical coupling involved in cardiac conduction|regulation of relaxation of cardiac muscle|negative regulation of sodium ion transmembrane transport|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|negative regulation of sodium ion transmembrane transporter activity "hsa04012,hsa04020,hsa04024,hsa04066,hsa04114,hsa04217,hsa04261,hsa04310,hsa04360,hsa04713,hsa04720,hsa04722,hsa04725,hsa04728,hsa04740,hsa04750,hsa04911,hsa04912,hsa04916,hsa04921,hsa04922,hsa04925,hsa04934,hsa04971,hsa05012,hsa05022,hsa05031,hsa05152,hsa05200,hsa05205,hsa05214" ErbB signaling pathway|Calcium signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|Oocyte meiosis|Necroptosis|Adrenergic signaling in cardiomyocytes|Wnt signaling pathway|Axon guidance|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Aldosterone synthesis and secretion|Cushing syndrome|Gastric acid secretion|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Pathways in cancer|Proteoglycans in cancer|Glioma CAMK2G 1755.32304 1655.393184 1855.252896 1.120732472 0.164441937 0.614421518 1 16.02443137 18.7327058 818 calcium/calmodulin dependent protein kinase II gamma "GO:0004683,GO:0004723,GO:0005515,GO:0005516,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0005954,GO:0006468,GO:0006470,GO:0007399,GO:0010975,GO:0014733,GO:0016020,GO:0030073,GO:0030154,GO:0030666,GO:0033017,GO:0042802,GO:0042803,GO:0043005,GO:0051924,GO:0060333,GO:1900034" calmodulin-dependent protein kinase activity|calcium-dependent protein serine/threonine phosphatase activity|protein binding|calmodulin binding|ATP binding|nucleoplasm|cytoplasm|cytosol|calcium- and calmodulin-dependent protein kinase complex|protein phosphorylation|protein dephosphorylation|nervous system development|regulation of neuron projection development|regulation of skeletal muscle adaptation|membrane|insulin secretion|cell differentiation|endocytic vesicle membrane|sarcoplasmic reticulum membrane|identical protein binding|protein homodimerization activity|neuron projection|regulation of calcium ion transport|interferon-gamma-mediated signaling pathway|regulation of cellular response to heat "hsa04012,hsa04020,hsa04024,hsa04066,hsa04114,hsa04217,hsa04261,hsa04310,hsa04360,hsa04713,hsa04720,hsa04722,hsa04725,hsa04728,hsa04740,hsa04750,hsa04911,hsa04912,hsa04916,hsa04921,hsa04922,hsa04925,hsa04934,hsa04971,hsa05012,hsa05022,hsa05031,hsa05152,hsa05200,hsa05205,hsa05214" ErbB signaling pathway|Calcium signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|Oocyte meiosis|Necroptosis|Adrenergic signaling in cardiomyocytes|Wnt signaling pathway|Axon guidance|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Aldosterone synthesis and secretion|Cushing syndrome|Gastric acid secretion|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Pathways in cancer|Proteoglycans in cancer|Glioma CAMK2N1 266.1859338 179.6472064 352.7246611 1.963429703 0.973375946 0.048569955 1 3.911649719 8.011083236 55450 calcium/calmodulin dependent protein kinase II inhibitor 1 "GO:0003084,GO:0005575,GO:0006469,GO:0008285,GO:0008427,GO:0010628,GO:0014069,GO:0019901,GO:0030425,GO:0035774,GO:0043025,GO:0045786,GO:0045861,GO:0055074,GO:0070373,GO:1904030" positive regulation of systemic arterial blood pressure|cellular_component|negative regulation of protein kinase activity|negative regulation of cell population proliferation|calcium-dependent protein kinase inhibitor activity|positive regulation of gene expression|postsynaptic density|protein kinase binding|dendrite|positive regulation of insulin secretion involved in cellular response to glucose stimulus|neuronal cell body|negative regulation of cell cycle|negative regulation of proteolysis|calcium ion homeostasis|negative regulation of ERK1 and ERK2 cascade|negative regulation of cyclin-dependent protein kinase activity CAMK2N2 222.8315778 213.1407534 232.5224023 1.090933567 0.12556325 0.816464495 1 7.434454024 8.459862696 94032 calcium/calmodulin dependent protein kinase II inhibitor 2 "GO:0005654,GO:0005813,GO:0005829,GO:0006469,GO:0008427,GO:0019901" nucleoplasm|centrosome|cytosol|negative regulation of protein kinase activity|calcium-dependent protein kinase inhibitor activity|protein kinase binding CAMK4 645.6488216 525.7471916 765.5504517 1.456118956 0.542128219 0.158785591 1 2.196785788 3.336571958 814 calcium/calmodulin dependent protein kinase IV "GO:0001650,GO:0002250,GO:0002372,GO:0004683,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0006954,GO:0007165,GO:0007616,GO:0009931,GO:0018105,GO:0033081,GO:0035556,GO:0043011,GO:0045670,GO:0045893,GO:0046777,GO:0070062,GO:0098794,GO:0098978" "fibrillar center|adaptive immune response|myeloid dendritic cell cytokine production|calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|inflammatory response|signal transduction|long-term memory|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|regulation of T cell differentiation in thymus|intracellular signal transduction|myeloid dendritic cell differentiation|regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|protein autophosphorylation|extracellular exosome|postsynapse|glutamatergic synapse" "hsa04020,hsa04024,hsa04211,hsa04371,hsa04380,hsa04720,hsa04722,hsa04725,hsa04921,hsa04925,hsa05031,hsa05034,hsa05214" Calcium signaling pathway|cAMP signaling pathway|Longevity regulating pathway|Apelin signaling pathway|Osteoclast differentiation|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Amphetamine addiction|Alcoholism|Glioma CAMKK1 31.95898883 29.43372308 34.48425458 1.171589964 0.228467741 0.841698646 1 0.197838651 0.24177017 84254 calcium/calmodulin dependent protein kinase kinase 1 "GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0035556,GO:0045860" protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|intracellular signal transduction|positive regulation of protein kinase activity hsa05034 Alcoholism CAMKK2 1130.215076 951.0137424 1309.41641 1.376863815 0.46138587 0.18167742 1 8.82960423 12.68084383 10645 calcium/calmodulin dependent protein kinase kinase 2 "GO:0000165,GO:0001934,GO:0004683,GO:0004713,GO:0005509,GO:0005516,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0018108,GO:0019722,GO:0034614,GO:0043005,GO:0045859,GO:0045893,GO:0046777,GO:0061762,GO:1903599" "MAPK cascade|positive regulation of protein phosphorylation|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity|calcium ion binding|calmodulin binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|peptidyl-tyrosine phosphorylation|calcium-mediated signaling|cellular response to reactive oxygen species|neuron projection|regulation of protein kinase activity|positive regulation of transcription, DNA-templated|protein autophosphorylation|CAMKK-AMPK signaling cascade|positive regulation of autophagy of mitochondrion" "hsa04140,hsa04152,hsa04211,hsa04920,hsa04921,hsa05034" Autophagy - animal|AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Alcoholism CAMKMT 45.61635708 53.79266632 37.44004783 0.696006545 -0.522827222 0.558294301 1 0.152244134 0.110527366 79823 calmodulin-lysine N-methyltransferase "GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006479,GO:0007005,GO:0018022,GO:0018025,GO:0022400,GO:0031072,GO:0032991" nucleoplasm|cytoplasm|Golgi apparatus|cytosol|protein methylation|mitochondrion organization|peptidyl-lysine methylation|calmodulin-lysine N-methyltransferase activity|regulation of rhodopsin mediated signaling pathway|heat shock protein binding|protein-containing complex hsa00310 Lysine degradation CAMLG 1236.824793 863.7275291 1609.922057 1.86392352 0.898342665 0.00870309 0.39115812 20.1495865 39.17510387 819 calcium modulating ligand "GO:0005515,GO:0005737,GO:0005783,GO:0006952,GO:0007165,GO:0016020,GO:0016021,GO:0016032,GO:0031397,GO:0031625,GO:0032435,GO:0050821,GO:0050839" protein binding|cytoplasm|endoplasmic reticulum|defense response|signal transduction|membrane|integral component of membrane|viral process|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|cell adhesion molecule binding CAMSAP1 1660.776751 1725.425146 1596.128355 0.925063807 -0.112375215 0.732729732 1 10.92060694 10.53742255 157922 calmodulin regulated spectrin associated protein 1 "GO:0000226,GO:0005516,GO:0005737,GO:0005874,GO:0007010,GO:0007026,GO:0008017,GO:0022604,GO:0030507,GO:0031113,GO:0031122,GO:0031175,GO:0036449,GO:0051011" microtubule cytoskeleton organization|calmodulin binding|cytoplasm|microtubule|cytoskeleton organization|negative regulation of microtubule depolymerization|microtubule binding|regulation of cell morphogenesis|spectrin binding|regulation of microtubule polymerization|cytoplasmic microtubule organization|neuron projection development|microtubule minus-end|microtubule minus-end binding CAMSAP2 2862.341103 2771.84475 2952.837456 1.065296841 0.091255488 0.775057405 1 17.43252925 19.37077389 23271 calmodulin regulated spectrin associated protein family member 2 "GO:0000226,GO:0005515,GO:0005516,GO:0005794,GO:0005813,GO:0005829,GO:0007026,GO:0030507,GO:0031113,GO:0031122,GO:0033043,GO:0036064,GO:0036449,GO:0050773,GO:0051011,GO:0061564,GO:1903358,GO:1990752" microtubule cytoskeleton organization|protein binding|calmodulin binding|Golgi apparatus|centrosome|cytosol|negative regulation of microtubule depolymerization|spectrin binding|regulation of microtubule polymerization|cytoplasmic microtubule organization|regulation of organelle organization|ciliary basal body|microtubule minus-end|regulation of dendrite development|microtubule minus-end binding|axon development|regulation of Golgi organization|microtubule end CAMSAP3 75.37000626 33.49354696 117.2464656 3.500568803 1.807589363 0.01781549 0.578240013 0.400928857 1.463935235 57662 calmodulin regulated spectrin associated protein family member 3 "GO:0000226,GO:0001701,GO:0003341,GO:0005515,GO:0005516,GO:0005654,GO:0005737,GO:0005813,GO:0005915,GO:0005930,GO:0007026,GO:0009792,GO:0010923,GO:0030334,GO:0030507,GO:0030951,GO:0031113,GO:0031122,GO:0031175,GO:0031514,GO:0033043,GO:0034453,GO:0036064,GO:0036449,GO:0045198,GO:0045218,GO:0051011,GO:0051015,GO:0051893,GO:0070507,GO:0090136,GO:0098840,GO:1903358" microtubule cytoskeleton organization|in utero embryonic development|cilium movement|protein binding|calmodulin binding|nucleoplasm|cytoplasm|centrosome|zonula adherens|axoneme|negative regulation of microtubule depolymerization|embryo development ending in birth or egg hatching|negative regulation of phosphatase activity|regulation of cell migration|spectrin binding|establishment or maintenance of microtubule cytoskeleton polarity|regulation of microtubule polymerization|cytoplasmic microtubule organization|neuron projection development|motile cilium|regulation of organelle organization|microtubule anchoring|ciliary basal body|microtubule minus-end|establishment of epithelial cell apical/basal polarity|zonula adherens maintenance|microtubule minus-end binding|actin filament binding|regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|epithelial cell-cell adhesion|protein transport along microtubule|regulation of Golgi organization CAMTA1 555.2838435 578.524902 532.0427849 0.919654077 -0.120836793 0.764787735 1 1.56068208 1.497114009 23261 calmodulin binding transcription activator 1 "GO:0003690,GO:0003712,GO:0005634,GO:0005730,GO:0005829,GO:0006357,GO:0035307,GO:0070886" double-stranded DNA binding|transcription coregulator activity|nucleus|nucleolus|cytosol|regulation of transcription by RNA polymerase II|positive regulation of protein dephosphorylation|positive regulation of calcineurin-NFAT signaling cascade CAMTA2 1595.449908 1368.160645 1822.739171 1.332255227 0.413870493 0.208733841 1 14.81558908 20.58838526 23125 calmodulin binding transcription activator 2 "GO:0000785,GO:0003682,GO:0003690,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0006357,GO:0008134,GO:0014898,GO:0042826,GO:0043565,GO:0045944" chromatin|chromatin binding|double-stranded DNA binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription factor binding|cardiac muscle hypertrophy in response to stress|histone deacetylase binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II CG_1 CAND1 3919.642407 3958.328277 3880.956537 0.98045343 -0.028478988 0.929559196 1 17.5655273 17.96404323 55832 cullin associated and neddylation dissociated 1 "GO:0000151,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006879,GO:0010265,GO:0016020,GO:0016567,GO:0017025,GO:0030154,GO:0031461,GO:0034774,GO:0043086,GO:0043312,GO:0043687,GO:0045899,GO:0070062,GO:1904813" ubiquitin ligase complex|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|cellular iron ion homeostasis|SCF complex assembly|membrane|protein ubiquitination|TBP-class protein binding|cell differentiation|cullin-RING ubiquitin ligase complex|secretory granule lumen|negative regulation of catalytic activity|neutrophil degranulation|post-translational protein modification|positive regulation of RNA polymerase II transcription preinitiation complex assembly|extracellular exosome|ficolin-1-rich granule lumen CAND2 369.2000052 250.6941242 487.7058862 1.945422087 0.960083202 0.031359781 0.79300461 2.465871624 5.003803367 23066 cullin associated and neddylation dissociated 2 (putative) "GO:0005515,GO:0005634,GO:0005829,GO:0010265,GO:0016567,GO:0017025,GO:0045893" "protein binding|nucleus|cytosol|SCF complex assembly|protein ubiquitination|TBP-class protein binding|positive regulation of transcription, DNA-templated" CANT1 1948.920571 1924.356516 1973.484626 1.02552963 0.036369176 0.911855117 1 25.36088181 27.12866937 124583 calcium activated nucleotidase 1 "GO:0004382,GO:0005509,GO:0005515,GO:0005576,GO:0005789,GO:0005794,GO:0005886,GO:0016020,GO:0016021,GO:0030166,GO:0032580,GO:0035580,GO:0042803,GO:0043123,GO:0043262,GO:0043312,GO:0045134,GO:0070062,GO:1904724,GO:1904813" guanosine-diphosphatase activity|calcium ion binding|protein binding|extracellular region|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|membrane|integral component of membrane|proteoglycan biosynthetic process|Golgi cisterna membrane|specific granule lumen|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|adenosine-diphosphatase activity|neutrophil degranulation|uridine-diphosphatase activity|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism CANX 22368.75307 23191.74388 21545.76226 0.92902726 -0.106207166 0.774032746 1 226.6653824 219.6491791 821 calnexin "GO:0002474,GO:0003723,GO:0005509,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0006457,GO:0009306,GO:0016020,GO:0016032,GO:0019886,GO:0030246,GO:0030968,GO:0034975,GO:0042470,GO:0044233,GO:0048488,GO:0051082,GO:0070062,GO:0070106,GO:0070757,GO:0071556,GO:0072583,GO:0098793" antigen processing and presentation of peptide antigen via MHC class I|RNA binding|calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein folding|protein secretion|membrane|viral process|antigen processing and presentation of exogenous peptide antigen via MHC class II|carbohydrate binding|endoplasmic reticulum unfolded protein response|protein folding in endoplasmic reticulum|melanosome|mitochondria-associated endoplasmic reticulum membrane|synaptic vesicle endocytosis|unfolded protein binding|extracellular exosome|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway|integral component of lumenal side of endoplasmic reticulum membrane|clathrin-dependent endocytosis|presynapse "hsa04141,hsa04145,hsa04612,hsa04918,hsa05166" Protein processing in endoplasmic reticulum|Phagosome|Antigen processing and presentation|Thyroid hormone synthesis|Human T-cell leukemia virus 1 infection CAP1 10487.46204 10360.67053 10614.25356 1.024475543 0.034885543 0.918007575 1 163.0613461 174.2482993 10487 cyclase associated actin cytoskeleton regulatory protein 1 "GO:0000902,GO:0001667,GO:0003779,GO:0005576,GO:0005737,GO:0005886,GO:0005925,GO:0006898,GO:0007163,GO:0007165,GO:0007190,GO:0008179,GO:0019933,GO:0030036,GO:0030864,GO:0035578,GO:0043312,GO:0045761,GO:0070062" cell morphogenesis|ameboidal-type cell migration|actin binding|extracellular region|cytoplasm|plasma membrane|focal adhesion|receptor-mediated endocytosis|establishment or maintenance of cell polarity|signal transduction|activation of adenylate cyclase activity|adenylate cyclase binding|cAMP-mediated signaling|actin cytoskeleton organization|cortical actin cytoskeleton|azurophil granule lumen|neutrophil degranulation|regulation of adenylate cyclase activity|extracellular exosome CAP2 617.8953928 548.0762229 687.7145627 1.254779051 0.327433348 0.399723148 1 9.489958015 12.42074026 10486 cyclase associated actin cytoskeleton regulatory protein 2 "GO:0000902,GO:0003779,GO:0005515,GO:0005737,GO:0005886,GO:0007010,GO:0007163,GO:0007165,GO:0007190,GO:0008179,GO:0014069,GO:0019933,GO:0042802,GO:0045761" cell morphogenesis|actin binding|protein binding|cytoplasm|plasma membrane|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction|activation of adenylate cyclase activity|adenylate cyclase binding|postsynaptic density|cAMP-mediated signaling|identical protein binding|regulation of adenylate cyclase activity CAPG 2659.992237 2544.494613 2775.489861 1.090782369 0.125363286 0.694588011 1 77.81985247 88.54100402 822 "capping actin protein, gelsolin like" "GO:0001726,GO:0005515,GO:0005546,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0007417,GO:0008154,GO:0008290,GO:0015629,GO:0019904,GO:0022617,GO:0030027,GO:0030031,GO:0042470,GO:0044877,GO:0045296,GO:0051014,GO:0051015,GO:0051016,GO:0065003,GO:0070062,GO:0071803,GO:0072686,GO:0090543" "ruffle|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|centriole|central nervous system development|actin polymerization or depolymerization|F-actin capping protein complex|actin cytoskeleton|protein domain specific binding|extracellular matrix disassembly|lamellipodium|cell projection assembly|melanosome|protein-containing complex binding|cadherin binding|actin filament severing|actin filament binding|barbed-end actin filament capping|protein-containing complex assembly|extracellular exosome|positive regulation of podosome assembly|mitotic spindle|Flemming body" CAPN1 5037.412025 5035.196559 5039.627491 1.000879992 0.001269001 0.997556045 1 79.12346963 82.6044151 823 calpain 1 "GO:0004198,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005764,GO:0005829,GO:0005886,GO:0005925,GO:0006508,GO:0008233,GO:0008284,GO:0016020,GO:0016241,GO:0022617,GO:0032801,GO:0043312,GO:0050790,GO:0060056,GO:0070062,GO:0070268,GO:0097264,GO:1904813,GO:2000310" calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|cytoplasm|mitochondrion|lysosome|cytosol|plasma membrane|focal adhesion|proteolysis|peptidase activity|positive regulation of cell population proliferation|membrane|regulation of macroautophagy|extracellular matrix disassembly|receptor catabolic process|neutrophil degranulation|regulation of catalytic activity|mammary gland involution|extracellular exosome|cornification|self proteolysis|ficolin-1-rich granule lumen|regulation of NMDA receptor activity "hsa04141,hsa04210,hsa04217,hsa04218,hsa05010,hsa05022,hsa05131" Protein processing in endoplasmic reticulum|Apoptosis|Necroptosis|Cellular senescence|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Shigellosis CAPN10 310.472852 243.5894324 377.3562715 1.549148778 0.631475705 0.177473137 1 4.706961244 7.605883708 11132 calpain 10 "GO:0000149,GO:0004198,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006508,GO:0006921,GO:0008092,GO:0031532,GO:0032024,GO:0032388,GO:0032869,GO:0046326,GO:0097050,GO:2000676" SNARE binding|calcium-dependent cysteine-type endopeptidase activity|protein binding|cytoplasm|mitochondrion|cytosol|plasma membrane|proteolysis|cellular component disassembly involved in execution phase of apoptosis|cytoskeletal protein binding|actin cytoskeleton reorganization|positive regulation of insulin secretion|positive regulation of intracellular transport|cellular response to insulin stimulus|positive regulation of glucose import|type B pancreatic cell apoptotic process|positive regulation of type B pancreatic cell apoptotic process CAPN12 6.508139139 7.104691779 5.911586499 0.832067975 -0.265226703 0.975312627 1 0.117552295 0.102024823 147968 calpain 12 "GO:0004198,GO:0005509,GO:0005737,GO:0006508" calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|proteolysis CAPN14 16.04630041 19.2841634 12.80843742 0.664194611 -0.590322077 0.648095474 1 0.237575978 0.164593926 440854 calpain 14 "GO:0004198,GO:0005509,GO:0005737,GO:0006508" calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|proteolysis CAPN15 1090.363085 1055.554207 1125.171964 1.065953748 0.092144841 0.792749336 1 5.74037333 6.382552985 6650 calpain 15 "GO:0004198,GO:0005515,GO:0005737,GO:0006508,GO:0046872" calcium-dependent cysteine-type endopeptidase activity|protein binding|cytoplasm|proteolysis|metal ion binding CAPN2 10614.08584 10698.65086 10529.52082 0.984191461 -0.022989096 0.946077831 1 150.4717922 154.472301 824 calpain 2 "GO:0000785,GO:0001666,GO:0001824,GO:0004198,GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005758,GO:0005764,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0006508,GO:0007520,GO:0007565,GO:0008092,GO:0008234,GO:0009897,GO:0010666,GO:0019899,GO:0022617,GO:0030425,GO:0030864,GO:0031143,GO:0032675,GO:0035458,GO:0042542,GO:0043025,GO:0044877,GO:0045121,GO:0048266,GO:0051493,GO:0051603,GO:0070062,GO:0071222,GO:0071230,GO:0097038,GO:1901216,GO:1901741,GO:2001247" chromatin|response to hypoxia|blastocyst development|calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|protein binding|nucleus|cytoplasm|mitochondrial intermembrane space|lysosome|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|focal adhesion|proteolysis|myoblast fusion|female pregnancy|cytoskeletal protein binding|cysteine-type peptidase activity|external side of plasma membrane|positive regulation of cardiac muscle cell apoptotic process|enzyme binding|extracellular matrix disassembly|dendrite|cortical actin cytoskeleton|pseudopodium|regulation of interleukin-6 production|cellular response to interferon-beta|response to hydrogen peroxide|neuronal cell body|protein-containing complex binding|membrane raft|behavioral response to pain|regulation of cytoskeleton organization|proteolysis involved in cellular protein catabolic process|extracellular exosome|cellular response to lipopolysaccharide|cellular response to amino acid stimulus|perinuclear endoplasmic reticulum|positive regulation of neuron death|positive regulation of myoblast fusion|positive regulation of phosphatidylcholine biosynthetic process "hsa04141,hsa04210,hsa04217,hsa04218,hsa04510,hsa05010,hsa05022,hsa05131" Protein processing in endoplasmic reticulum|Apoptosis|Necroptosis|Cellular senescence|Focal adhesion|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Shigellosis CAPN3 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.041690137 0.056285119 825 calpain 3 "GO:0003824,GO:0004198,GO:0005509,GO:0005515,GO:0005622,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006915,GO:0007517,GO:0008233,GO:0008234,GO:0008307,GO:0014718,GO:0014850,GO:0030016,GO:0030018,GO:0030163,GO:0030239,GO:0030315,GO:0031402,GO:0031432,GO:0031648,GO:0032991,GO:0033234,GO:0043066,GO:0043122,GO:0045214,GO:0045661,GO:0045862,GO:0045892,GO:0045893,GO:0046716,GO:0050790,GO:0051092,GO:0051281,GO:0051592,GO:0055103,GO:0060090,GO:0061061,GO:0065003,GO:0070315,GO:0071277,GO:0071472,GO:0072657,GO:0097264,GO:1990092" "catalytic activity|calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|protein binding|intracellular anatomical structure|nucleus|cytoplasm|cytosol|plasma membrane|proteolysis|apoptotic process|muscle organ development|peptidase activity|cysteine-type peptidase activity|structural constituent of muscle|positive regulation of satellite cell activation involved in skeletal muscle regeneration|response to muscle activity|myofibril|Z disc|protein catabolic process|myofibril assembly|T-tubule|sodium ion binding|titin binding|protein destabilization|protein-containing complex|negative regulation of protein sumoylation|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|sarcomere organization|regulation of myoblast differentiation|positive regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|muscle cell cellular homeostasis|regulation of catalytic activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion|ligase regulator activity|molecular adaptor activity|muscle structure development|protein-containing complex assembly|G1 to G0 transition involved in cell differentiation|cellular response to calcium ion|cellular response to salt stress|protein localization to membrane|self proteolysis|calcium-dependent self proteolysis" CAPN5 758.5316208 766.2917561 750.7714854 0.979746264 -0.029519928 0.940346199 1 8.470094747 8.656011293 726 calpain 5 "GO:0004198,GO:0005737,GO:0005925,GO:0006508,GO:0007165,GO:0009986,GO:0070062" calcium-dependent cysteine-type endopeptidase activity|cytoplasm|focal adhesion|proteolysis|signal transduction|cell surface|extracellular exosome CAPN6 6.522984915 8.119647747 4.926322083 0.606716232 -0.720906186 0.726457076 1 0.116430213 0.073682989 827 calpain 6 "GO:0001578,GO:0004198,GO:0005515,GO:0005737,GO:0005876,GO:0006508,GO:0008017,GO:0048471,GO:0051493" microtubule bundle formation|calcium-dependent cysteine-type endopeptidase activity|protein binding|cytoplasm|spindle microtubule|proteolysis|microtubule binding|perinuclear region of cytoplasm|regulation of cytoskeleton organization CAPN7 1154.035366 1198.662999 1109.407733 0.925537648 -0.111636419 0.747296001 1 15.53032803 14.99307274 23473 calpain 7 "GO:0004175,GO:0004198,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0010634,GO:0070062,GO:0090541,GO:0097264" endopeptidase activity|calcium-dependent cysteine-type endopeptidase activity|protein binding|nucleus|centrosome|cytosol|positive regulation of epithelial cell migration|extracellular exosome|MIT domain binding|self proteolysis CAPNS1 7099.75677 6967.672723 7231.840817 1.03791339 0.053686061 0.870256439 1 157.4690062 170.4794876 826 calpain small subunit 1 "GO:0004198,GO:0005509,GO:0005515,GO:0005829,GO:0005886,GO:0006508,GO:0008284,GO:0016020,GO:0016241,GO:0022617,GO:0070062,GO:0070268" calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|protein binding|cytosol|plasma membrane|proteolysis|positive regulation of cell population proliferation|membrane|regulation of macroautophagy|extracellular matrix disassembly|extracellular exosome|cornification hsa05131 Shigellosis CAPRIN1 7227.928735 7175.738696 7280.118774 1.014546248 0.020834632 0.949812544 1 53.34299875 56.45016368 4076 cell cycle associated protein 1 "GO:0000932,GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0010494,GO:0016020,GO:0017148,GO:0030027,GO:0030425,GO:0031252,GO:0045202,GO:0050775,GO:0061003" P-body|RNA binding|protein binding|cytoplasm|cytosol|cytoplasmic stress granule|membrane|negative regulation of translation|lamellipodium|dendrite|cell leading edge|synapse|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis CAPRIN2 1749.3684 1450.372079 2048.364722 1.41230292 0.498049561 0.126817363 1 14.69418467 21.64657949 65981 caprin family member 2 "GO:0003723,GO:0005102,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0017148,GO:0030308,GO:0032092,GO:0033138,GO:0043235,GO:0045944,GO:0046872,GO:0050775,GO:0061003,GO:0090263" RNA binding|signaling receptor binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|centrosome|cytosol|plasma membrane|negative regulation of translation|negative regulation of cell growth|positive regulation of protein binding|positive regulation of peptidyl-serine phosphorylation|receptor complex|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of canonical Wnt signaling pathway CAPS 47.42358237 42.62815067 52.21901408 1.224988963 0.292768751 0.751379261 1 1.48280594 1.894664956 828 calcyphosine "GO:0005509,GO:0005737,GO:0031982,GO:0035556" calcium ion binding|cytoplasm|vesicle|intracellular signal transduction CAPS2 64.5145303 65.97213794 63.05692266 0.955811417 -0.065202094 0.954818189 1 0.627230346 0.625338554 84698 calcyphosine 2 GO:0005509 calcium ion binding CAPSL 3.970749218 2.029911937 5.911586499 2.912237912 1.542128219 0.515744462 1 0.086977901 0.264211491 133690 calcyphosine like "GO:0005509,GO:0005737" calcium ion binding|cytoplasm CAPZA1 5309.27894 4929.641138 5688.916741 1.15402249 0.20667134 0.521166886 1 97.60317941 117.4881776 829 capping actin protein of muscle Z-line subunit alpha 1 "GO:0003779,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0006888,GO:0007596,GO:0008290,GO:0015629,GO:0019886,GO:0030036,GO:0034329,GO:0035722,GO:0045087,GO:0045296,GO:0051015,GO:0051016,GO:0065003,GO:0070062,GO:0071203" actin binding|protein binding|extracellular region|cytosol|cytoskeleton|endoplasmic reticulum to Golgi vesicle-mediated transport|blood coagulation|F-actin capping protein complex|actin cytoskeleton|antigen processing and presentation of exogenous peptide antigen via MHC class II|actin cytoskeleton organization|cell junction assembly|interleukin-12-mediated signaling pathway|innate immune response|cadherin binding|actin filament binding|barbed-end actin filament capping|protein-containing complex assembly|extracellular exosome|WASH complex hsa04144 Endocytosis CAPZA2 1521.550871 1603.63043 1439.471313 0.897632825 -0.155802662 0.638663686 1 16.02569535 15.00484583 830 capping actin protein of muscle Z-line subunit alpha 2 "GO:0005515,GO:0005576,GO:0005829,GO:0005903,GO:0006888,GO:0007596,GO:0008290,GO:0015629,GO:0016020,GO:0019886,GO:0030036,GO:0030863,GO:0045087,GO:0051015,GO:0051016,GO:0065003,GO:0070062" protein binding|extracellular region|cytosol|brush border|endoplasmic reticulum to Golgi vesicle-mediated transport|blood coagulation|F-actin capping protein complex|actin cytoskeleton|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|actin cytoskeleton organization|cortical cytoskeleton|innate immune response|actin filament binding|barbed-end actin filament capping|protein-containing complex assembly|extracellular exosome hsa04144 Endocytosis CAPZB 3019.995288 3176.812181 2863.178394 0.901274054 -0.149962235 0.637754358 1 41.84507928 39.33844544 832 capping actin protein of muscle Z-line subunit beta "GO:0000902,GO:0003779,GO:0005515,GO:0005829,GO:0005856,GO:0006888,GO:0007010,GO:0007596,GO:0008290,GO:0010591,GO:0015629,GO:0019886,GO:0022604,GO:0030017,GO:0030036,GO:0045296,GO:0051015,GO:0051016,GO:0051490,GO:0070062,GO:0071203" cell morphogenesis|actin binding|protein binding|cytosol|cytoskeleton|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|blood coagulation|F-actin capping protein complex|regulation of lamellipodium assembly|actin cytoskeleton|antigen processing and presentation of exogenous peptide antigen via MHC class II|regulation of cell morphogenesis|sarcomere|actin cytoskeleton organization|cadherin binding|actin filament binding|barbed-end actin filament capping|negative regulation of filopodium assembly|extracellular exosome|WASH complex hsa04144 Endocytosis CARD10 851.939983 921.5800193 782.2999467 0.848868172 -0.236387571 0.515622982 1 11.35363095 10.05289053 29775 caspase recruitment domain family member 10 "GO:0005515,GO:0005737,GO:0007250,GO:0030159,GO:0032449,GO:0042981,GO:0050700,GO:0065003,GO:0090051,GO:1900182" protein binding|cytoplasm|activation of NF-kappaB-inducing kinase activity|signaling receptor complex adaptor activity|CBM complex|regulation of apoptotic process|CARD domain binding|protein-containing complex assembly|negative regulation of cell migration involved in sprouting angiogenesis|positive regulation of protein localization to nucleus hsa04064 NF-kappa B signaling pathway CARD11 2117.820674 1717.305498 2518.335849 1.466446041 0.552323987 0.085870999 1 20.00355686 30.59773239 84433 caspase recruitment domain family member 11 "GO:0001772,GO:0002223,GO:0004385,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007249,GO:0030183,GO:0030890,GO:0031295,GO:0032449,GO:0032743,GO:0038095,GO:0038202,GO:0042100,GO:0042102,GO:0042981,GO:0043123,GO:0045061,GO:0045121,GO:0045577,GO:0045580,GO:0046037,GO:0046710,GO:0048872,GO:0050700,GO:0050852,GO:0050862,GO:0051092,GO:0070062" immunological synapse|stimulatory C-type lectin receptor signaling pathway|guanylate kinase activity|protein binding|cytoplasm|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|B cell differentiation|positive regulation of B cell proliferation|T cell costimulation|CBM complex|positive regulation of interleukin-2 production|Fc-epsilon receptor signaling pathway|TORC1 signaling|B cell proliferation|positive regulation of T cell proliferation|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|thymic T cell selection|membrane raft|regulation of B cell differentiation|regulation of T cell differentiation|GMP metabolic process|GDP metabolic process|homeostasis of number of cells|CARD domain binding|T cell receptor signaling pathway|positive regulation of T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|extracellular exosome "hsa04064,hsa04660,hsa04662" NF-kappa B signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway CARD14 6.015506931 7.104691779 4.926322083 0.693389979 -0.528261108 0.84291128 1 0.066011296 0.047743225 79092 caspase recruitment domain family member 14 "GO:0001934,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0007250,GO:0016235,GO:0033209,GO:0043066,GO:0050700,GO:0051092" positive regulation of protein phosphorylation|cytoplasm|cytosol|plasma membrane|apoptotic process|activation of NF-kappaB-inducing kinase activity|aggresome|tumor necrosis factor-mediated signaling pathway|negative regulation of apoptotic process|CARD domain binding|positive regulation of NF-kappaB transcription factor activity hsa04064 NF-kappa B signaling pathway CARD16 17.00187327 17.25425146 16.74949508 0.970745971 -0.042834281 1 1 0.424619518 0.42995349 114769 caspase recruitment domain family member 16 "GO:0004869,GO:0005515,GO:0010804,GO:0019900,GO:0031665,GO:0032091,GO:0032691,GO:0032991,GO:0042802,GO:0043123,GO:0043154,GO:0050700,GO:0051092,GO:0071222,GO:0071456,GO:0071494,GO:0089720,GO:0097179,GO:0097340" cysteine-type endopeptidase inhibitor activity|protein binding|negative regulation of tumor necrosis factor-mediated signaling pathway|kinase binding|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein binding|negative regulation of interleukin-1 beta production|protein-containing complex|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|CARD domain binding|positive regulation of NF-kappaB transcription factor activity|cellular response to lipopolysaccharide|cellular response to hypoxia|cellular response to UV-C|caspase binding|protease inhibitor complex|inhibition of cysteine-type endopeptidase activity hsa04621 NOD-like receptor signaling pathway CARD19 573.3061159 530.8219715 615.7902603 1.160069276 0.214210962 0.589570527 1 31.37019863 37.95920632 84270 caspase recruitment domain family member 19 "GO:0005634,GO:0005739,GO:0005789,GO:0005829,GO:0016021,GO:0031966,GO:0043124,GO:0050700" nucleus|mitochondrion|endoplasmic reticulum membrane|cytosol|integral component of membrane|mitochondrial membrane|negative regulation of I-kappaB kinase/NF-kappaB signaling|CARD domain binding CARD6 218.638142 195.8865019 241.3897821 1.232294108 0.30134662 0.568391474 1 2.294394143 2.949159946 84674 caspase recruitment domain family member 6 "GO:0005515,GO:0006915,GO:0042981" protein binding|apoptotic process|regulation of apoptotic process hsa04621 NOD-like receptor signaling pathway CARD8 383.5524033 356.2495449 410.8552617 1.153279401 0.205742072 0.642275683 1 2.146672537 2.582356903 22900 caspase recruitment domain family member 8 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0008656,GO:0010804,GO:0031665,GO:0032088,GO:0032089,GO:0032691,GO:0032731,GO:0032991,GO:0042803,GO:0042981,GO:0043122,GO:0043124,GO:0043280,GO:0050700,GO:0061702,GO:0072559,GO:0097340" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cysteine-type endopeptidase activator activity involved in apoptotic process|negative regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|NACHT domain binding|negative regulation of interleukin-1 beta production|positive regulation of interleukin-1 beta production|protein-containing complex|protein homodimerization activity|regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|CARD domain binding|inflammasome complex|NLRP3 inflammasome complex|inhibition of cysteine-type endopeptidase activity hsa04621 NOD-like receptor signaling pathway CARD9 8.986145956 8.119647747 9.852644165 1.213432463 0.279093814 0.926248221 1 0.194804128 0.246564016 64170 caspase recruitment domain family member 9 "GO:0002223,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007249,GO:0009620,GO:0032494,GO:0032495,GO:0032663,GO:0032755,GO:0032760,GO:0032874,GO:0032991,GO:0042493,GO:0042803,GO:0042981,GO:0043123,GO:0043280,GO:0043330,GO:0045087,GO:0046330,GO:0050700,GO:0050830,GO:0051607" stimulatory C-type lectin receptor signaling pathway|protein binding|cytoplasm|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|response to fungus|response to peptidoglycan|response to muramyl dipeptide|regulation of interleukin-2 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of stress-activated MAPK cascade|protein-containing complex|response to drug|protein homodimerization activity|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to exogenous dsRNA|innate immune response|positive regulation of JNK cascade|CARD domain binding|defense response to Gram-positive bacterium|defense response to virus "hsa04621,hsa04625,hsa05152,hsa05168" NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Tuberculosis|Herpes simplex virus 1 infection CARF 113.4160093 108.6002886 118.23173 1.08868707 0.122589328 0.862764449 1 0.80565717 0.914890822 79800 calcium responsive transcription factor "GO:0000978,GO:0000981,GO:0001228,GO:0001652,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0035865,GO:0051090,GO:0061400,GO:0071277" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|granular component|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|cellular response to potassium ion|regulation of DNA-binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|cellular response to calcium ion" CARHSP1 1475.882058 1276.814608 1674.949508 1.311818879 0.391568543 0.23867475 1 17.63943142 24.13650527 23589 calcium regulated heat stable protein 1 "GO:0000177,GO:0000932,GO:0003730,GO:0005515,GO:0005737,GO:0005829,GO:0019902,GO:0035556,GO:0043186,GO:0043488" cytoplasmic exosome (RNase complex)|P-body|mRNA 3'-UTR binding|protein binding|cytoplasm|cytosol|phosphatase binding|intracellular signal transduction|P granule|regulation of mRNA stability CARM1 1481.157752 1570.136883 1392.178621 0.88666067 -0.173546012 0.601979861 1 21.45181927 19.83980977 10498 coactivator associated arginine methyltransferase 1 "GO:0000976,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006977,GO:0007568,GO:0008013,GO:0008276,GO:0008284,GO:0008469,GO:0016032,GO:0016274,GO:0016571,GO:0019216,GO:0019919,GO:0030374,GO:0033146,GO:0034970,GO:0034971,GO:0035242,GO:0035642,GO:0042054,GO:0045600,GO:0045893,GO:0051591,GO:0070577,GO:1902415,GO:2000171" "transcription regulatory region sequence-specific DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|aging|beta-catenin binding|protein methyltransferase activity|positive regulation of cell population proliferation|histone-arginine N-methyltransferase activity|viral process|protein-arginine N-methyltransferase activity|histone methylation|regulation of lipid metabolic process|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|nuclear receptor coactivator activity|regulation of intracellular estrogen receptor signaling pathway|histone H3-R2 methylation|histone H3-R17 methylation|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity (H3-R17 specific)|histone methyltransferase activity|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|response to cAMP|lysine-acetylated histone binding|regulation of mRNA binding|negative regulation of dendrite development" hsa01522 Endocrine resistance other CARMIL1 437.763473 458.7600977 416.7668482 0.908463596 -0.138499391 0.747060031 1 3.047557783 2.887855161 55604 capping protein regulator and myosin 1 linker 1 "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0007015,GO:0007596,GO:0016477,GO:0016607,GO:0030027,GO:0030032,GO:0030335,GO:0030838,GO:0031252,GO:0031529,GO:0031941,GO:0044351,GO:0044354,GO:0044877,GO:0046415,GO:0051496,GO:0051638,GO:0051639,GO:0070062,GO:1900026,GO:1902745,GO:2000813" protein binding|nucleoplasm|cytosol|plasma membrane|actin filament organization|blood coagulation|cell migration|nuclear speck|lamellipodium|lamellipodium assembly|positive regulation of cell migration|positive regulation of actin filament polymerization|cell leading edge|ruffle organization|filamentous actin|macropinocytosis|macropinosome|protein-containing complex binding|urate metabolic process|positive regulation of stress fiber assembly|barbed-end actin filament uncapping|actin filament network formation|extracellular exosome|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of lamellipodium organization|negative regulation of barbed-end actin filament capping CARMIL2 92.84694436 83.22638941 102.4674993 1.231190011 0.300053432 0.674649514 1 0.934202797 1.199726291 146206 capping protein regulator and myosin 1 linker 2 "GO:0001726,GO:0005543,GO:0005737,GO:0005886,GO:0007163,GO:0010592,GO:0015629,GO:0016020,GO:0030011,GO:0030027,GO:0030335,GO:0031234,GO:0031252,GO:0044319,GO:0044354,GO:0044877,GO:0045111,GO:0051639,GO:0061339,GO:0090091,GO:1900029,GO:1902745,GO:2000813" "ruffle|phospholipid binding|cytoplasm|plasma membrane|establishment or maintenance of cell polarity|positive regulation of lamellipodium assembly|actin cytoskeleton|membrane|maintenance of cell polarity|lamellipodium|positive regulation of cell migration|extrinsic component of cytoplasmic side of plasma membrane|cell leading edge|wound healing, spreading of cells|macropinosome|protein-containing complex binding|intermediate filament cytoskeleton|actin filament network formation|establishment or maintenance of monopolar cell polarity|positive regulation of extracellular matrix disassembly|positive regulation of ruffle assembly|positive regulation of lamellipodium organization|negative regulation of barbed-end actin filament capping" CARMIL3 12.49395452 12.17947162 12.80843742 1.051641468 0.072642936 1 1 0.134418669 0.147449472 90668 capping protein regulator and myosin 1 linker 3 "GO:0005737,GO:0005886" cytoplasm|plasma membrane CARNMT1 271.2471056 357.2645009 185.2297103 0.518466598 -0.947677048 0.053182198 1 3.078813445 1.665022422 138199 carnosine N-methyltransferase 1 "GO:0005515,GO:0005634,GO:0005829,GO:0006548,GO:0008757,GO:0030735,GO:0032259,GO:0035498,GO:0042803" protein binding|nucleus|cytosol|histidine catabolic process|S-adenosylmethionine-dependent methyltransferase activity|carnosine N-methyltransferase activity|methylation|carnosine metabolic process|protein homodimerization activity hsa00340 Histidine metabolism CARNS1 26.09193966 32.47859099 19.70528833 0.606716232 -0.720906186 0.494172706 1 0.24540147 0.155302592 57571 carnosine synthase 1 "GO:0005524,GO:0005575,GO:0005829,GO:0006548,GO:0016887,GO:0035499,GO:0046872,GO:0047730,GO:0102102" ATP binding|cellular_component|cytosol|histidine catabolic process|ATPase activity|carnosine biosynthetic process|metal ion binding|carnosine synthase activity|homocarnosine synthase activity "hsa00330,hsa00340,hsa00410" Arginine and proline metabolism|Histidine metabolism|beta-Alanine metabolism CARS1 1762.719451 1386.429853 2139.009048 1.542818083 0.625567961 0.055262925 1 20.40028501 32.82969782 833 cysteinyl-tRNA synthetase 1 "GO:0000049,GO:0004817,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006418,GO:0006423,GO:0042802,GO:0046872" tRNA binding|cysteine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|tRNA aminoacylation for protein translation|cysteinyl-tRNA aminoacylation|identical protein binding|metal ion binding hsa00970 Aminoacyl-tRNA biosynthesis CARS2 613.2456973 634.3474802 592.1439143 0.933469325 -0.09932548 0.80175606 1 7.851285931 7.644635359 79587 "cysteinyl-tRNA synthetase 2, mitochondrial" "GO:0004817,GO:0005524,GO:0005737,GO:0005759,GO:0006423,GO:0046872" cysteine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrial matrix|cysteinyl-tRNA aminoacylation|metal ion binding hsa00970 Aminoacyl-tRNA biosynthesis CASC3 2334.575878 2121.257974 2547.893781 1.201123962 0.264385052 0.408330908 1 27.39970238 34.32808731 22794 CASC3 exon junction complex subunit "GO:0000184,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006405,GO:0006406,GO:0006417,GO:0008298,GO:0010494,GO:0016607,GO:0019899,GO:0030425,GO:0031124,GO:0031625,GO:0031965,GO:0035145,GO:0042802,GO:0048471,GO:0071006" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|regulation of translation|intracellular mRNA localization|cytoplasmic stress granule|nuclear speck|enzyme binding|dendrite|mRNA 3'-end processing|ubiquitin protein ligase binding|nuclear membrane|exon-exon junction complex|identical protein binding|perinuclear region of cytoplasm|U2-type catalytic step 1 spliceosome" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway CASD1 324.4419815 289.262451 359.621512 1.243236067 0.314100263 0.49799824 1 2.295897616 2.977296231 64921 CAS1 domain containing 1 "GO:0005975,GO:0030173,GO:0047186" carbohydrate metabolic process|integral component of Golgi membrane|N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity CASK 1855.73465 2154.751521 1556.717778 0.722458141 -0.469014094 0.148205705 1 12.65575357 9.53710642 8573 calcium/calmodulin dependent serine protein kinase "GO:0001953,GO:0004385,GO:0004674,GO:0005515,GO:0005516,GO:0005524,GO:0005604,GO:0005652,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0006468,GO:0007155,GO:0007269,GO:0010839,GO:0015629,GO:0016363,GO:0042734,GO:0046037,GO:0046710,GO:0060170,GO:0061045,GO:0090288,GO:0106310,GO:0106311" negative regulation of cell-matrix adhesion|guanylate kinase activity|protein serine/threonine kinase activity|protein binding|calmodulin binding|ATP binding|basement membrane|nuclear lamina|nucleolus|cytoplasm|cytosol|plasma membrane|cell-cell junction|focal adhesion|protein phosphorylation|cell adhesion|neurotransmitter secretion|negative regulation of keratinocyte proliferation|actin cytoskeleton|nuclear matrix|presynaptic membrane|GMP metabolic process|GDP metabolic process|ciliary membrane|negative regulation of wound healing|negative regulation of cellular response to growth factor stimulus|protein serine kinase activity|protein threonine kinase activity CASKIN1 66.66320845 78.15160956 55.17480733 0.705997069 -0.5022659 0.522688813 1 0.689565039 0.507801597 57524 CASK interacting protein 1 "GO:0005515,GO:0005737,GO:0007165,GO:0016020,GO:0042802" protein binding|cytoplasm|signal transduction|membrane|identical protein binding CASKIN2 512.5572156 419.1768149 605.9376162 1.44554182 0.531610348 0.190742212 1 4.134338249 6.23379614 57513 CASK interacting protein 2 "GO:0003674,GO:0005737,GO:0008150,GO:0016020" molecular_function|cytoplasm|biological_process|membrane CASP1 316.767707 303.4718345 330.0635795 1.087625084 0.12118133 0.799756495 1 6.351147866 7.205222042 834 caspase 1 "GO:0001666,GO:0004175,GO:0004197,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006508,GO:0006915,GO:0006919,GO:0007165,GO:0008656,GO:0010506,GO:0016540,GO:0019221,GO:0019900,GO:0032611,GO:0032730,GO:0032731,GO:0032991,GO:0033198,GO:0042802,GO:0042981,GO:0043123,GO:0043280,GO:0050700,GO:0050727,GO:0051882,GO:0060081,GO:0070269,GO:0071222,GO:0071260,GO:0071310,GO:0071345,GO:0071346,GO:0072557,GO:0072558,GO:0072559,GO:0097153,GO:0097169,GO:0097179,GO:0097190,GO:0097194,GO:0097199,GO:0097200,GO:0097300,GO:0140448,GO:1901998,GO:1903265" response to hypoxia|endopeptidase activity|cysteine-type endopeptidase activity|protein binding|extracellular region|cytoplasm|mitochondrion|cytosol|plasma membrane|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|cysteine-type endopeptidase activator activity involved in apoptotic process|regulation of autophagy|protein autoprocessing|cytokine-mediated signaling pathway|kinase binding|interleukin-1 beta production|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-1 beta production|protein-containing complex|response to ATP|identical protein binding|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|CARD domain binding|regulation of inflammatory response|mitochondrial depolarization|membrane hyperpolarization|pyroptosis|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to organic substance|cellular response to cytokine stimulus|cellular response to interferon-gamma|IPAF inflammasome complex|NLRP1 inflammasome complex|NLRP3 inflammasome complex|cysteine-type endopeptidase activity involved in apoptotic process|AIM2 inflammasome complex|protease inhibitor complex|apoptotic signaling pathway|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|programmed necrotic cell death|signaling receptor ligand precursor processing|toxin transport|positive regulation of tumor necrosis factor-mediated signaling pathway "hsa04217,hsa04621,hsa04623,hsa04625,hsa05014,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05164,hsa05171" Necroptosis|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|Amyotrophic lateral sclerosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Influenza A|Coronavirus disease - COVID-19 CASP10 149.9544242 181.6771183 118.23173 0.650779422 -0.619759463 0.296399146 1 1.37641064 0.934324554 843 caspase 10 "GO:0004197,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0006919,GO:0007166,GO:0031265,GO:0031625,GO:0035877,GO:0042981,GO:0043123,GO:0097153,GO:0097190,GO:0097194,GO:0097199,GO:0097200,GO:0097342" cysteine-type endopeptidase activity|protein binding|cytoplasm|cytosol|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell surface receptor signaling pathway|CD95 death-inducing signaling complex|ubiquitin protein ligase binding|death effector domain binding|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|cysteine-type endopeptidase activity involved in apoptotic process|apoptotic signaling pathway|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|ripoptosome "hsa04210,hsa04622,hsa04668,hsa05152,hsa05161" Apoptosis|RIG-I-like receptor signaling pathway|TNF signaling pathway|Tuberculosis|Hepatitis B CASP2 832.6518602 748.0225487 917.2811718 1.226274761 0.294282267 0.419947667 1 8.979545681 11.48571626 835 caspase 2 "GO:0001554,GO:0003407,GO:0004197,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0006919,GO:0006977,GO:0007420,GO:0007568,GO:0008630,GO:0016020,GO:0016485,GO:0019899,GO:0019904,GO:0035234,GO:0042802,GO:0042981,GO:0043065,GO:0043066,GO:0043525,GO:0071260,GO:0097153,GO:0097190,GO:0097192,GO:0097194,GO:0097199,GO:0097200,GO:2001235" "luteolysis|neural retina development|cysteine-type endopeptidase activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|brain development|aging|intrinsic apoptotic signaling pathway in response to DNA damage|membrane|protein processing|enzyme binding|protein domain specific binding|ectopic germ cell programmed cell death|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of neuron apoptotic process|cellular response to mechanical stimulus|cysteine-type endopeptidase activity involved in apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|positive regulation of apoptotic signaling pathway" hsa04210 Apoptosis CASP3 838.6592024 855.6078813 821.7105234 0.960382135 -0.058319529 0.875711388 1 15.27441691 15.30117009 836 caspase 3 "GO:0001554,GO:0001666,GO:0001782,GO:0002020,GO:0004190,GO:0004197,GO:0004861,GO:0005123,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006309,GO:0006508,GO:0006915,GO:0006974,GO:0007413,GO:0007507,GO:0007605,GO:0007611,GO:0008233,GO:0008627,GO:0009411,GO:0009749,GO:0010165,GO:0016005,GO:0016241,GO:0016485,GO:0019221,GO:0021766,GO:0030182,GO:0030216,GO:0030218,GO:0030220,GO:0030889,GO:0031264,GO:0031647,GO:0032025,GO:0032355,GO:0032496,GO:0034349,GO:0034612,GO:0035094,GO:0035329,GO:0042060,GO:0042493,GO:0042542,GO:0043025,GO:0043029,GO:0043065,GO:0043066,GO:0043200,GO:0043525,GO:0044877,GO:0045121,GO:0045165,GO:0045736,GO:0046007,GO:0046677,GO:0048011,GO:0051146,GO:0051384,GO:0051402,GO:0061713,GO:0071887,GO:0072734,GO:0097153,GO:0097190,GO:0097192,GO:0097194,GO:0097199,GO:0097200,GO:1902004" luteolysis|response to hypoxia|B cell homeostasis|protease binding|aspartic-type endopeptidase activity|cysteine-type endopeptidase activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|death receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic DNA fragmentation|proteolysis|apoptotic process|cellular response to DNA damage stimulus|axonal fasciculation|heart development|sensory perception of sound|learning or memory|peptidase activity|intrinsic apoptotic signaling pathway in response to osmotic stress|response to UV|response to glucose|response to X-ray|phospholipase A2 activator activity|regulation of macroautophagy|protein processing|cytokine-mediated signaling pathway|hippocampus development|neuron differentiation|keratinocyte differentiation|erythrocyte differentiation|platelet formation|negative regulation of B cell proliferation|death-inducing signaling complex|regulation of protein stability|response to cobalt ion|response to estradiol|response to lipopolysaccharide|glial cell apoptotic process|response to tumor necrosis factor|response to nicotine|hippo signaling|wound healing|response to drug|response to hydrogen peroxide|neuronal cell body|T cell homeostasis|positive regulation of apoptotic process|negative regulation of apoptotic process|response to amino acid|positive regulation of neuron apoptotic process|protein-containing complex binding|membrane raft|cell fate commitment|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of activated T cell proliferation|response to antibiotic|neurotrophin TRK receptor signaling pathway|striated muscle cell differentiation|response to glucocorticoid|neuron apoptotic process|anterior neural tube closure|leukocyte apoptotic process|cellular response to staurosporine|cysteine-type endopeptidase activity involved in apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|positive regulation of amyloid-beta formation "hsa01524,hsa04010,hsa04115,hsa04210,hsa04215,hsa04650,hsa04657,hsa04668,hsa04726,hsa04932,hsa04933,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05120,hsa05130,hsa05132,hsa05133,hsa05134,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05222,hsa05416" Platinum drug resistance|MAPK signaling pathway|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|TNF signaling pathway|Serotonergic synapse|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Legionellosis|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Small cell lung cancer|Viral myocarditis CASP4 1071.915729 1006.836321 1136.995137 1.12927505 0.175396917 0.615660219 1 37.05865388 43.65211622 837 caspase 4 "GO:0004197,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0006508,GO:0006915,GO:0006919,GO:0006954,GO:0016540,GO:0032991,GO:0042981,GO:0045087,GO:0050700,GO:0050727,GO:0070059,GO:0070269,GO:0072557,GO:0072559,GO:0097153,GO:0097169,GO:0097193,GO:0097194,GO:0097199,GO:0097200,GO:1903265,GO:1904646" cysteine-type endopeptidase activity|protein binding|extracellular region|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|protein autoprocessing|protein-containing complex|regulation of apoptotic process|innate immune response|CARD domain binding|regulation of inflammatory response|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|pyroptosis|IPAF inflammasome complex|NLRP3 inflammasome complex|cysteine-type endopeptidase activity involved in apoptotic process|AIM2 inflammasome complex|intrinsic apoptotic signaling pathway|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|positive regulation of tumor necrosis factor-mediated signaling pathway|cellular response to amyloid-beta "hsa04621,hsa05130,hsa05131,hsa05132" NOD-like receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection CASP6 378.2373694 363.3542367 393.1205022 1.081920788 0.113594878 0.801370511 1 11.26230738 12.7098016 839 caspase 6 "GO:0004197,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0008234,GO:0030855,GO:0042802,GO:0042981,GO:0072734,GO:0097153,GO:0097194,GO:0097200" cysteine-type endopeptidase activity|protein binding|nucleoplasm|cytoplasm|cytosol|proteolysis|apoptotic process|cysteine-type peptidase activity|epithelial cell differentiation|identical protein binding|regulation of apoptotic process|cellular response to staurosporine|cysteine-type endopeptidase activity involved in apoptotic process|execution phase of apoptosis|cysteine-type endopeptidase activity involved in execution phase of apoptosis hsa04210 Apoptosis CASP7 196.3306374 253.7389921 138.9222827 0.547500727 -0.869067214 0.10978833 1 3.344868509 1.910203691 840 caspase 7 "GO:0004197,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0008233,GO:0008234,GO:0072734,GO:0097153,GO:0097194,GO:0097200" cysteine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteolysis|apoptotic process|peptidase activity|cysteine-type peptidase activity|cellular response to staurosporine|cysteine-type endopeptidase activity involved in apoptotic process|execution phase of apoptosis|cysteine-type endopeptidase activity involved in execution phase of apoptosis "hsa04210,hsa04215,hsa04668,hsa04932,hsa05010,hsa05022,hsa05130,hsa05132,hsa05133,hsa05134,hsa05200" Apoptosis|Apoptosis - multiple species|TNF signaling pathway|Non-alcoholic fatty liver disease|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Legionellosis|Pathways in cancer CASP8 686.3725075 716.5589137 656.1861014 0.915746199 -0.126980287 0.740360604 1 12.0568708 11.51663655 841 caspase 8 "GO:0001525,GO:0004197,GO:0005123,GO:0005164,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0005856,GO:0006508,GO:0006915,GO:0006919,GO:0007166,GO:0007507,GO:0008233,GO:0008234,GO:0008625,GO:0009409,GO:0010803,GO:0030101,GO:0030225,GO:0031264,GO:0031265,GO:0031625,GO:0032025,GO:0032355,GO:0032496,GO:0032731,GO:0032991,GO:0034138,GO:0034612,GO:0035666,GO:0035877,GO:0036462,GO:0039650,GO:0042110,GO:0042113,GO:0042802,GO:0043005,GO:0043065,GO:0043123,GO:0043124,GO:0044297,GO:0044877,GO:0045121,GO:0045471,GO:0045651,GO:0045862,GO:0046677,GO:0051603,GO:0060544,GO:0060546,GO:0060715,GO:0070269,GO:0070423,GO:0071260,GO:0071407,GO:0071550,GO:0097110,GO:0097153,GO:0097190,GO:0097191,GO:0097194,GO:0097199,GO:0097200,GO:0097202,GO:0097264,GO:0097296,GO:0097342,GO:1900740,GO:1901216,GO:1902041,GO:1902042" angiogenesis|cysteine-type endopeptidase activity|death receptor binding|tumor necrosis factor receptor binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|cytoskeleton|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell surface receptor signaling pathway|heart development|peptidase activity|cysteine-type peptidase activity|extrinsic apoptotic signaling pathway via death domain receptors|response to cold|regulation of tumor necrosis factor-mediated signaling pathway|natural killer cell activation|macrophage differentiation|death-inducing signaling complex|CD95 death-inducing signaling complex|ubiquitin protein ligase binding|response to cobalt ion|response to estradiol|response to lipopolysaccharide|positive regulation of interleukin-1 beta production|protein-containing complex|toll-like receptor 3 signaling pathway|response to tumor necrosis factor|TRIF-dependent toll-like receptor signaling pathway|death effector domain binding|TRAIL-activated apoptotic signaling pathway|suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process|T cell activation|B cell activation|identical protein binding|neuron projection|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|cell body|protein-containing complex binding|membrane raft|response to ethanol|positive regulation of macrophage differentiation|positive regulation of proteolysis|response to antibiotic|proteolysis involved in cellular protein catabolic process|regulation of necroptotic process|negative regulation of necroptotic process|syncytiotrophoblast cell differentiation involved in labyrinthine layer development|pyroptosis|nucleotide-binding oligomerization domain containing signaling pathway|cellular response to mechanical stimulus|cellular response to organic cyclic compound|death-inducing signaling complex assembly|scaffold protein binding|cysteine-type endopeptidase activity involved in apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|activation of cysteine-type endopeptidase activity|self proteolysis|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|ripoptosome|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of neuron death|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors "hsa01524,hsa04115,hsa04210,hsa04215,hsa04217,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04668,hsa04932,hsa05010,hsa05016,hsa05022,hsa05130,hsa05132,hsa05134,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05416" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Non-alcoholic fatty liver disease|Alzheimer disease|Huntington disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection|Legionellosis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Viral myocarditis CASP8AP2 628.1758429 611.003493 645.3481928 1.056210317 0.078897138 0.841953529 1 4.680860903 5.156939907 9994 caspase 8 associated protein 2 "GO:0003714,GO:0005123,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006919,GO:0007049,GO:0007165,GO:0008625,GO:0008656,GO:0016505,GO:0016605,GO:0032184,GO:0036337,GO:0045892,GO:0071260,GO:0097190" "transcription corepressor activity|death receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell cycle|signal transduction|extrinsic apoptotic signaling pathway via death domain receptors|cysteine-type endopeptidase activator activity involved in apoptotic process|peptidase activator activity involved in apoptotic process|PML body|SUMO polymer binding|Fas signaling pathway|negative regulation of transcription, DNA-templated|cellular response to mechanical stimulus|apoptotic signaling pathway" other CASP9 124.533266 161.377999 87.68853307 0.543373531 -0.879983806 0.163426819 1 2.074949566 1.176039622 842 caspase 9 "GO:0004197,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0006919,GO:0006974,GO:0008047,GO:0008233,GO:0008630,GO:0008635,GO:0017124,GO:0019901,GO:0030220,GO:0032991,GO:0034644,GO:0042770,GO:0043065,GO:0043293,GO:0097153,GO:0097192,GO:0097194,GO:0097199,GO:0097200,GO:2001020" cysteine-type endopeptidase activity|protein binding|cytoplasm|cytosol|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|enzyme activator activity|peptidase activity|intrinsic apoptotic signaling pathway in response to DNA damage|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|SH3 domain binding|protein kinase binding|platelet formation|protein-containing complex|cellular response to UV|signal transduction in response to DNA damage|positive regulation of apoptotic process|apoptosome|cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway in absence of ligand|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|regulation of response to DNA damage stimulus "hsa01524,hsa04115,hsa04151,hsa04210,hsa04215,hsa04370,hsa04919,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05134,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05210,hsa05212,hsa05213,hsa05215,hsa05222,hsa05223,hsa05416" Platinum drug resistance|p53 signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|VEGF signaling pathway|Thyroid hormone signaling pathway|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Legionellosis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Prostate cancer|Small cell lung cancer|Non-small cell lung cancer|Viral myocarditis CAST 4093.864224 3845.668164 4342.060284 1.129078251 0.175145476 0.583037772 1 39.98553189 47.0915352 831 calpastatin "GO:0003723,GO:0004866,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0010859,GO:0016020,GO:0045296,GO:0097340,GO:1990709,GO:2000675" RNA binding|endopeptidase inhibitor activity|protein binding|cytoplasm|endoplasmic reticulum|cytosol|calcium-dependent cysteine-type endopeptidase inhibitor activity|membrane|cadherin binding|inhibition of cysteine-type endopeptidase activity|presynaptic active zone organization|negative regulation of type B pancreatic cell apoptotic process hsa05131 Shigellosis CASTOR1 150.8533355 142.0938356 159.6128355 1.123291766 0.167732705 0.785294594 1 4.79450466 5.617618601 652968 cytosolic arginine sensor for mTORC1 subunit 1 "GO:0005515,GO:0005829,GO:0034618,GO:0042802,GO:0061700,GO:1902531,GO:1903577,GO:1904262" protein binding|cytosol|arginine binding|identical protein binding|GATOR2 complex|regulation of intracellular signal transduction|cellular response to L-arginine|negative regulation of TORC1 signaling hsa04150 mTOR signaling pathway CASTOR2 330.8489218 255.768904 405.9289396 1.587092618 0.666386322 0.14673927 1 1.596277596 2.642570727 729438 cytosolic arginine sensor for mTORC1 subunit 2 "GO:0005515,GO:0005829,GO:0034618,GO:0042802,GO:0061700,GO:1902531,GO:1903577,GO:1904262" protein binding|cytosol|arginine binding|identical protein binding|GATOR2 complex|regulation of intracellular signal transduction|cellular response to L-arginine|negative regulation of TORC1 signaling hsa04150 mTOR signaling pathway CASZ1 16.46470374 14.20938356 18.72002391 1.31744096 0.39773831 0.775274639 1 0.078573551 0.107975064 54897 castor zinc finger 1 "GO:0000785,GO:0000977,GO:0001228,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0007275,GO:0043231,GO:0045664,GO:0045893,GO:0045944,GO:0046872" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|multicellular organism development|intracellular membrane-bounded organelle|regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding" other CAT 1171.099344 1186.483527 1155.715161 0.974067599 -0.037906198 0.914547671 1 26.22924705 26.64960957 847 catalase "GO:0000268,GO:0000302,GO:0001649,GO:0001657,GO:0001666,GO:0004046,GO:0004096,GO:0005576,GO:0005737,GO:0005739,GO:0005758,GO:0005764,GO:0005777,GO:0005778,GO:0005782,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0006625,GO:0006641,GO:0007568,GO:0008203,GO:0009060,GO:0009642,GO:0009650,GO:0010193,GO:0010288,GO:0014068,GO:0014823,GO:0014854,GO:0016020,GO:0016209,GO:0016684,GO:0019899,GO:0020027,GO:0020037,GO:0032088,GO:0032355,GO:0032868,GO:0032991,GO:0033189,GO:0033197,GO:0033591,GO:0034599,GO:0034774,GO:0042493,GO:0042542,GO:0042744,GO:0042802,GO:0042803,GO:0043066,GO:0043231,GO:0043312,GO:0045471,GO:0046686,GO:0046872,GO:0050661,GO:0051092,GO:0051781,GO:0055093,GO:0070062,GO:0070542,GO:0071363,GO:0080184,GO:0098869,GO:1904813" "peroxisome targeting sequence binding|response to reactive oxygen species|osteoblast differentiation|ureteric bud development|response to hypoxia|aminoacylase activity|catalase activity|extracellular region|cytoplasm|mitochondrion|mitochondrial intermembrane space|lysosome|peroxisome|peroxisomal membrane|peroxisomal matrix|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|focal adhesion|protein targeting to peroxisome|triglyceride metabolic process|aging|cholesterol metabolic process|aerobic respiration|response to light intensity|UV protection|response to ozone|response to lead ion|positive regulation of phosphatidylinositol 3-kinase signaling|response to activity|response to inactivity|membrane|antioxidant activity|oxidoreductase activity, acting on peroxide as acceptor|enzyme binding|hemoglobin metabolic process|heme binding|negative regulation of NF-kappaB transcription factor activity|response to estradiol|response to insulin|protein-containing complex|response to vitamin A|response to vitamin E|response to L-ascorbic acid|cellular response to oxidative stress|secretory granule lumen|response to drug|response to hydrogen peroxide|hydrogen peroxide catabolic process|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|neutrophil degranulation|response to ethanol|response to cadmium ion|metal ion binding|NADP binding|positive regulation of NF-kappaB transcription factor activity|positive regulation of cell division|response to hyperoxia|extracellular exosome|response to fatty acid|cellular response to growth factor stimulus|response to phenylpropanoid|cellular oxidant detoxification|ficolin-1-rich granule lumen" "hsa00380,hsa00630,hsa04068,hsa04146,hsa04211,hsa04213,hsa05014,hsa05022" Tryptophan metabolism|Glyoxylate and dicarboxylate metabolism|FoxO signaling pathway|Peroxisome|Longevity regulating pathway|Longevity regulating pathway - multiple species|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases CATSPER1 195.1996368 210.0958855 180.3033882 0.858195713 -0.2206214 0.690270488 1 4.12267161 3.690464339 117144 cation channel sperm associated 1 "GO:0005227,GO:0005245,GO:0005515,GO:0005886,GO:0006816,GO:0007275,GO:0007283,GO:0030154,GO:0030317,GO:0031514,GO:0032570,GO:0034765,GO:0035036,GO:0036128,GO:0060296,GO:0070588" calcium activated cation channel activity|voltage-gated calcium channel activity|protein binding|plasma membrane|calcium ion transport|multicellular organism development|spermatogenesis|cell differentiation|flagellated sperm motility|motile cilium|response to progesterone|regulation of ion transmembrane transport|sperm-egg recognition|CatSper complex|regulation of cilium beat frequency involved in ciliary motility|calcium ion transmembrane transport CATSPER2 64.8883963 57.8524902 71.92430241 1.243236067 0.314100263 0.699661754 1 0.724178086 0.939106636 117155 cation channel sperm associated 2 "GO:0005227,GO:0005244,GO:0005262,GO:0005515,GO:0005886,GO:0007275,GO:0009566,GO:0030317,GO:0031514,GO:0032570,GO:0034765,GO:0035036,GO:0036128,GO:0048240,GO:0070588" calcium activated cation channel activity|voltage-gated ion channel activity|calcium channel activity|protein binding|plasma membrane|multicellular organism development|fertilization|flagellated sperm motility|motile cilium|response to progesterone|regulation of ion transmembrane transport|sperm-egg recognition|CatSper complex|sperm capacitation|calcium ion transmembrane transport CATSPER3 8.493513748 8.119647747 8.867379749 1.092089217 0.12709072 1 1 0.303491892 0.345717324 347732 cation channel sperm associated 3 "GO:0001669,GO:0005245,GO:0005783,GO:0005886,GO:0006814,GO:0007275,GO:0030317,GO:0031514,GO:0032570,GO:0034765,GO:0035036,GO:0036128,GO:0048240,GO:0070588" acrosomal vesicle|voltage-gated calcium channel activity|endoplasmic reticulum|plasma membrane|sodium ion transport|multicellular organism development|flagellated sperm motility|motile cilium|response to progesterone|regulation of ion transmembrane transport|sperm-egg recognition|CatSper complex|sperm capacitation|calcium ion transmembrane transport CATSPERE 14.00154269 14.20938356 13.79370183 0.970745971 -0.042834281 1 1 0.136479262 0.138193683 257044 catsper channel auxiliary subunit epsilon "GO:0036128,GO:0097228" CatSper complex|sperm principal piece CATSPERG 5.552566274 9.134603715 1.970528833 0.215721327 -2.212759283 0.247208451 1 0.125341494 0.028203557 57828 cation channel sperm associated auxiliary subunit gamma "GO:0005886,GO:0007275,GO:0007283,GO:0030154,GO:0031514,GO:0032570,GO:0035036,GO:0036128,GO:0097228" plasma membrane|multicellular organism development|spermatogenesis|cell differentiation|motile cilium|response to progesterone|sperm-egg recognition|CatSper complex|sperm principal piece CATSPERZ 35.77855869 54.80762229 16.74949508 0.305605213 -1.710258942 0.073159091 1 3.558734256 1.134415747 25858 catsper channel auxiliary subunit zeta "GO:0005737,GO:0007140,GO:0007283,GO:0030317,GO:0036128,GO:0048240,GO:0097228" cytoplasm|male meiotic nuclear division|spermatogenesis|flagellated sperm motility|CatSper complex|sperm capacitation|sperm principal piece CAV1 4715.46265 5118.422949 4312.502351 0.842545134 -0.247174123 0.440392871 1 80.43129557 70.68612412 857 caveolin 1 "GO:0000122,GO:0000139,GO:0000188,GO:0001525,GO:0001570,GO:0001666,GO:0001937,GO:0001960,GO:0002080,GO:0002095,GO:0002931,GO:0003057,GO:0005102,GO:0005113,GO:0005515,GO:0005768,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0005886,GO:0005887,GO:0005901,GO:0005925,GO:0005929,GO:0005938,GO:0006641,GO:0006816,GO:0006874,GO:0006940,GO:0007519,GO:0007595,GO:0008104,GO:0009617,GO:0010524,GO:0010608,GO:0010628,GO:0010875,GO:0010952,GO:0015031,GO:0015485,GO:0016020,GO:0016050,GO:0016504,GO:0019065,GO:0019217,GO:0019899,GO:0019901,GO:0019915,GO:0030154,GO:0030193,GO:0030301,GO:0030335,GO:0030512,GO:0030666,GO:0030674,GO:0030857,GO:0030879,GO:0031267,GO:0031295,GO:0031397,GO:0031398,GO:0031410,GO:0031623,GO:0031901,GO:0032091,GO:0032092,GO:0032507,GO:0032570,GO:0032991,GO:0033137,GO:0033138,GO:0033484,GO:0034141,GO:0038016,GO:0042310,GO:0042383,GO:0042532,GO:0042632,GO:0042802,GO:0043085,GO:0043409,GO:0043627,GO:0044325,GO:0044860,GO:0044877,GO:0045019,GO:0045121,GO:0045907,GO:0046426,GO:0046982,GO:0048471,GO:0048550,GO:0050900,GO:0050998,GO:0050999,GO:0051001,GO:0051092,GO:0051117,GO:0051480,GO:0051592,GO:0051899,GO:0052547,GO:0055074,GO:0060056,GO:0060090,GO:0060355,GO:0060546,GO:0061099,GO:0070320,GO:0070836,GO:0071360,GO:0071375,GO:0071455,GO:0071560,GO:0071711,GO:0072584,GO:0086091,GO:0086098,GO:0090090,GO:0090263,GO:0097190,GO:0098903,GO:0098909,GO:0098911,GO:0120162,GO:1900027,GO:1900085,GO:1901380,GO:1901844,GO:1903071,GO:1903361,GO:1903598,GO:1903609,GO:1904886,GO:2000286,GO:2000535,GO:2000811,GO:2001238,GO:2001244" negative regulation of transcription by RNA polymerase II|Golgi membrane|inactivation of MAPK activity|angiogenesis|vasculogenesis|response to hypoxia|negative regulation of endothelial cell proliferation|negative regulation of cytokine-mediated signaling pathway|acrosomal membrane|caveolar macromolecular signaling complex|response to ischemia|regulation of the force of heart contraction by chemical signal|signaling receptor binding|patched binding|protein binding|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|plasma membrane|integral component of plasma membrane|caveola|focal adhesion|cilium|cell cortex|triglyceride metabolic process|calcium ion transport|cellular calcium ion homeostasis|regulation of smooth muscle contraction|skeletal muscle tissue development|lactation|protein localization|response to bacterium|positive regulation of calcium ion transport into cytosol|posttranscriptional regulation of gene expression|positive regulation of gene expression|positive regulation of cholesterol efflux|positive regulation of peptidase activity|protein transport|cholesterol binding|membrane|vesicle organization|peptidase activator activity|receptor-mediated endocytosis of virus by host cell|regulation of fatty acid metabolic process|enzyme binding|protein kinase binding|lipid storage|cell differentiation|regulation of blood coagulation|cholesterol transport|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|protein-macromolecule adaptor activity|negative regulation of epithelial cell differentiation|mammary gland development|small GTPase binding|T cell costimulation|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|cytoplasmic vesicle|receptor internalization|early endosome membrane|negative regulation of protein binding|positive regulation of protein binding|maintenance of protein location in cell|response to progesterone|protein-containing complex|negative regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-serine phosphorylation|nitric oxide homeostasis|positive regulation of toll-like receptor 3 signaling pathway|insulin receptor internalization|vasoconstriction|sarcolemma|negative regulation of tyrosine phosphorylation of STAT protein|cholesterol homeostasis|identical protein binding|positive regulation of catalytic activity|negative regulation of MAPK cascade|response to estrogen|ion channel binding|protein localization to plasma membrane raft|protein-containing complex binding|negative regulation of nitric oxide biosynthetic process|membrane raft|positive regulation of vasoconstriction|negative regulation of receptor signaling pathway via JAK-STAT|protein heterodimerization activity|perinuclear region of cytoplasm|negative regulation of pinocytosis|leukocyte migration|nitric-oxide synthase binding|regulation of nitric-oxide synthase activity|negative regulation of nitric-oxide synthase activity|positive regulation of NF-kappaB transcription factor activity|ATPase binding|regulation of cytosolic calcium ion concentration|response to calcium ion|membrane depolarization|regulation of peptidase activity|calcium ion homeostasis|mammary gland involution|molecular adaptor activity|positive regulation of cell adhesion molecule production|negative regulation of necroptotic process|negative regulation of protein tyrosine kinase activity|inward rectifier potassium channel inhibitor activity|caveola assembly|cellular response to exogenous dsRNA|cellular response to peptide hormone stimulus|cellular response to hyperoxia|cellular response to transforming growth factor beta stimulus|basement membrane organization|caveolin-mediated endocytosis|regulation of heart rate by cardiac conduction|angiotensin-activated signaling pathway involved in heart process|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|apoptotic signaling pathway|regulation of membrane repolarization during action potential|regulation of cardiac muscle cell action potential involved in regulation of contraction|regulation of ventricular cardiac muscle cell action potential|positive regulation of cold-induced thermogenesis|regulation of ruffle assembly|negative regulation of peptidyl-tyrosine autophosphorylation|negative regulation of potassium ion transmembrane transport|regulation of cell communication by electrical coupling involved in cardiac conduction|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|protein localization to basolateral plasma membrane|positive regulation of gap junction assembly|negative regulation of inward rectifier potassium channel activity|beta-catenin destruction complex disassembly|receptor internalization involved in canonical Wnt signaling pathway|regulation of entry of bacterium into host cell|negative regulation of anoikis|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway "hsa04144,hsa04510,hsa05020,hsa05100,hsa05205,hsa05416,hsa05418" Endocytosis|Focal adhesion|Prion disease|Bacterial invasion of epithelial cells|Proteoglycans in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis CAV2 1238.958379 1245.350973 1232.565785 0.989733667 -0.014887741 0.967698887 1 19.91557735 20.56019239 858 caveolin 2 "GO:0000139,GO:0001937,GO:0001938,GO:0002080,GO:0002095,GO:0005515,GO:0005634,GO:0005794,GO:0005886,GO:0005887,GO:0005901,GO:0005925,GO:0006906,GO:0007005,GO:0007029,GO:0007088,GO:0008286,GO:0016050,GO:0019065,GO:0019901,GO:0030133,GO:0030154,GO:0030512,GO:0030674,GO:0031234,GO:0031410,GO:0032991,GO:0042383,GO:0042803,GO:0043410,GO:0043547,GO:0044791,GO:0044794,GO:0045121,GO:0046982,GO:0048278,GO:0048471,GO:0048741,GO:0051480,GO:0060090,GO:0060161,GO:0070836,GO:0071711,GO:0097110" Golgi membrane|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|acrosomal membrane|caveolar macromolecular signaling complex|protein binding|nucleus|Golgi apparatus|plasma membrane|integral component of plasma membrane|caveola|focal adhesion|vesicle fusion|mitochondrion organization|endoplasmic reticulum organization|regulation of mitotic nuclear division|insulin receptor signaling pathway|vesicle organization|receptor-mediated endocytosis of virus by host cell|protein kinase binding|transport vesicle|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|protein-macromolecule adaptor activity|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|protein-containing complex|sarcolemma|protein homodimerization activity|positive regulation of MAPK cascade|positive regulation of GTPase activity|positive regulation by host of viral release from host cell|positive regulation by host of viral process|membrane raft|protein heterodimerization activity|vesicle docking|perinuclear region of cytoplasm|skeletal muscle fiber development|regulation of cytosolic calcium ion concentration|molecular adaptor activity|positive regulation of dopamine receptor signaling pathway|caveola assembly|basement membrane organization|scaffold protein binding "hsa04144,hsa04510,hsa05020,hsa05100,hsa05205,hsa05418" Endocytosis|Focal adhesion|Prion disease|Bacterial invasion of epithelial cells|Proteoglycans in cancer|Fluid shear stress and atherosclerosis CAVIN1 9186.253856 9103.14008 9269.367631 1.018260463 0.026106638 0.93802696 1 103.2106405 109.6223945 284119 caveolae associated protein 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0005901,GO:0006361,GO:0006363,GO:0009303,GO:0009306,GO:0032991,GO:0042134,GO:0042802,GO:0043231,GO:0045121,GO:2000147" RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|caveola|transcription initiation from RNA polymerase I promoter|termination of RNA polymerase I transcription|rRNA transcription|protein secretion|protein-containing complex|rRNA primary transcript binding|identical protein binding|intracellular membrane-bounded organelle|membrane raft|positive regulation of cell motility CAVIN3 671.8864975 601.8688892 741.9041057 1.232667312 0.301783479 0.429097136 1 29.65227235 38.12587235 112464 caveolae associated protein 3 "GO:0005080,GO:0005515,GO:0005737,GO:0005829,GO:0005901,GO:0032922,GO:0032991" protein kinase C binding|protein binding|cytoplasm|cytosol|caveola|circadian regulation of gene expression|protein-containing complex CAVIN4 47.16848258 58.86744617 35.469519 0.602531982 -0.730890275 0.401534284 1 0.962372007 0.604837926 347273 caveolae associated protein 4 "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005901,GO:0007517,GO:0010468,GO:0030018,GO:0030154,GO:0035023,GO:0042383,GO:0045944" protein binding|cytoplasm|cytosol|plasma membrane|caveola|muscle organ development|regulation of gene expression|Z disc|cell differentiation|regulation of Rho protein signal transduction|sarcolemma|positive regulation of transcription by RNA polymerase II CBARP 205.2601219 224.305269 186.2149747 0.830185468 -0.268494416 0.619709615 1 2.44622536 2.118300267 255057 CACN subunit beta associated regulatory protein "GO:0005886,GO:0016021,GO:0030141,GO:0030426,GO:0030672,GO:0044325,GO:0045955,GO:1901386,GO:1903170" plasma membrane|integral component of membrane|secretory granule|growth cone|synaptic vesicle membrane|ion channel binding|negative regulation of calcium ion-dependent exocytosis|negative regulation of voltage-gated calcium channel activity|negative regulation of calcium ion transmembrane transport CBFA2T2 1316.880621 1284.934256 1348.826986 1.049724513 0.070010761 0.837473472 1 7.241280415 7.928784869 9139 CBFA2/RUNX1 partner transcriptional co-repressor 2 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0006351,GO:0010976,GO:0010977,GO:0045746,GO:0045892,GO:0046872,GO:0060575" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|transcription, DNA-templated|positive regulation of neuron projection development|negative regulation of neuron projection development|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|metal ion binding|intestinal epithelial cell differentiation" CBFB 870.619429 1053.524295 687.7145627 0.652775229 -0.615341783 0.088990178 1 17.19538799 11.70823889 865 core-binding factor subunit beta "GO:0000122,GO:0000209,GO:0001649,GO:0001959,GO:0003713,GO:0005515,GO:0005654,GO:0006357,GO:0006366,GO:0006367,GO:0016020,GO:0016513,GO:0030098,GO:0030099,GO:0030111,GO:0033146,GO:0043371,GO:0043378,GO:0043565,GO:0045589,GO:0045616,GO:0045637,GO:0045652,GO:0045944,GO:0048469,GO:0050855,GO:0060216,GO:1902036,GO:2000810" "negative regulation of transcription by RNA polymerase II|protein polyubiquitination|osteoblast differentiation|regulation of cytokine-mediated signaling pathway|transcription coactivator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|core-binding factor complex|lymphocyte differentiation|myeloid cell differentiation|regulation of Wnt signaling pathway|regulation of intracellular estrogen receptor signaling pathway|negative regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|sequence-specific DNA binding|regulation of regulatory T cell differentiation|regulation of keratinocyte differentiation|regulation of myeloid cell differentiation|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|cell maturation|regulation of B cell receptor signaling pathway|definitive hemopoiesis|regulation of hematopoietic stem cell differentiation|regulation of bicellular tight junction assembly" CBF CBL 4350.022086 3979.642352 4720.40182 1.186137196 0.24627089 0.440799623 1 18.04753275 22.32897017 867 Cbl proto-oncogene "GO:0000209,GO:0001784,GO:0004842,GO:0005154,GO:0005509,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0005929,GO:0006511,GO:0006513,GO:0006974,GO:0007165,GO:0007166,GO:0007173,GO:0007175,GO:0007179,GO:0008543,GO:0008584,GO:0010332,GO:0014068,GO:0014823,GO:0016567,GO:0016600,GO:0017124,GO:0019221,GO:0030426,GO:0030971,GO:0032487,GO:0033574,GO:0035635,GO:0036120,GO:0036312,GO:0042059,GO:0042594,GO:0043066,GO:0043303,GO:0045121,GO:0045296,GO:0045471,GO:0045742,GO:0046677,GO:0046875,GO:0048260,GO:0048471,GO:0061024,GO:0061630,GO:0070102,GO:0070997,GO:0071364,GO:0090650,GO:1901215,GO:1990090,GO:2000583" protein polyubiquitination|phosphotyrosine residue binding|ubiquitin-protein transferase activity|epidermal growth factor receptor binding|calcium ion binding|protein binding|Golgi apparatus|cytosol|plasma membrane|focal adhesion|cilium|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|signal transduction|cell surface receptor signaling pathway|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor-activated receptor activity|transforming growth factor beta receptor signaling pathway|fibroblast growth factor receptor signaling pathway|male gonad development|response to gamma radiation|positive regulation of phosphatidylinositol 3-kinase signaling|response to activity|protein ubiquitination|flotillin complex|SH3 domain binding|cytokine-mediated signaling pathway|growth cone|receptor tyrosine kinase binding|regulation of Rap protein signal transduction|response to testosterone|entry of bacterium into host cell|cellular response to platelet-derived growth factor stimulus|phosphatidylinositol 3-kinase regulatory subunit binding|negative regulation of epidermal growth factor receptor signaling pathway|response to starvation|negative regulation of apoptotic process|mast cell degranulation|membrane raft|cadherin binding|response to ethanol|positive regulation of epidermal growth factor receptor signaling pathway|response to antibiotic|ephrin receptor binding|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|membrane organization|ubiquitin protein ligase activity|interleukin-6-mediated signaling pathway|neuron death|cellular response to epidermal growth factor stimulus|cellular response to oxygen-glucose deprivation|negative regulation of neuron death|cellular response to nerve growth factor stimulus|regulation of platelet-derived growth factor receptor-alpha signaling pathway "hsa04012,hsa04120,hsa04144,hsa04910,hsa05100,hsa05200,hsa05205,hsa05220" ErbB signaling pathway|Ubiquitin mediated proteolysis|Endocytosis|Insulin signaling pathway|Bacterial invasion of epithelial cells|Pathways in cancer|Proteoglycans in cancer|Chronic myeloid leukemia CBLB 357.2471796 376.5486643 337.9456949 0.897482124 -0.156044892 0.73186713 1 2.1367912 2.000340017 868 Cbl proto-oncogene B "GO:0001784,GO:0002669,GO:0005509,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006607,GO:0006955,GO:0007165,GO:0007175,GO:0008270,GO:0016567,GO:0017124,GO:0018193,GO:0030971,GO:0031398,GO:0035556,GO:0042110,GO:0043087,GO:0043393,GO:0045121,GO:0045732,GO:0046642,GO:0050852,GO:0050860,GO:0061630,GO:2000583" phosphotyrosine residue binding|positive regulation of T cell anergy|calcium ion binding|protein binding|nucleoplasm|cytosol|plasma membrane|NLS-bearing protein import into nucleus|immune response|signal transduction|negative regulation of epidermal growth factor-activated receptor activity|zinc ion binding|protein ubiquitination|SH3 domain binding|peptidyl-amino acid modification|receptor tyrosine kinase binding|positive regulation of protein ubiquitination|intracellular signal transduction|T cell activation|regulation of GTPase activity|regulation of protein binding|membrane raft|positive regulation of protein catabolic process|negative regulation of alpha-beta T cell proliferation|T cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|ubiquitin protein ligase activity|regulation of platelet-derived growth factor receptor-alpha signaling pathway "hsa04012,hsa04120,hsa04144,hsa04625,hsa04660,hsa04910,hsa05162" ErbB signaling pathway|Ubiquitin mediated proteolysis|Endocytosis|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|Insulin signaling pathway|Measles CBLL1 812.9141588 779.4861837 846.3421338 1.085769256 0.118717539 0.748075576 1 4.366577297 4.945322544 79872 Cbl proto-oncogene like 1 "GO:0000151,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0007162,GO:0007275,GO:0016567,GO:0016607,GO:0030155,GO:0030335,GO:0035635,GO:0036396,GO:0042802,GO:0045807,GO:0046872,GO:0061630,GO:0080009,GO:0098609" ubiquitin ligase complex|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|negative regulation of cell adhesion|multicellular organism development|protein ubiquitination|nuclear speck|regulation of cell adhesion|positive regulation of cell migration|entry of bacterium into host cell|RNA N6-methyladenosine methyltransferase complex|identical protein binding|positive regulation of endocytosis|metal ion binding|ubiquitin protein ligase activity|mRNA methylation|cell-cell adhesion CBLN3 37.49670933 37.55337083 37.44004783 0.996982348 -0.004360133 1 1 0.768152566 0.798823595 643866 cerebellin 3 precursor "GO:0005615,GO:0005783,GO:0005794,GO:0045202" extracellular space|endoplasmic reticulum|Golgi apparatus|synapse CBR1 1611.154509 1734.55975 1487.749269 0.857710015 -0.221438129 0.500964638 1 47.77016432 42.73789679 873 carbonyl reductase 1 "GO:0004090,GO:0005829,GO:0016655,GO:0017144,GO:0019371,GO:0030855,GO:0042373,GO:0047020,GO:0047021,GO:0050221,GO:0055114,GO:0070062,GO:1903561" "carbonyl reductase (NADPH) activity|cytosol|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|drug metabolic process|cyclooxygenase pathway|epithelial cell differentiation|vitamin K metabolic process|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity|15-hydroxyprostaglandin dehydrogenase (NADP+) activity|prostaglandin-E2 9-reductase activity|oxidation-reduction process|extracellular exosome|extracellular vesicle" "hsa00590,hsa00790,hsa00980,hsa05204" Arachidonic acid metabolism|Folate biosynthesis|Metabolism of xenobiotics by cytochrome P450|Chemical carcinogenesis CBR3 260.6576158 239.5296085 281.7856231 1.17641249 0.234394006 0.639504801 1 8.489383949 10.41721751 874 carbonyl reductase 3 "GO:0000253,GO:0004090,GO:0005515,GO:0005615,GO:0005654,GO:0005829,GO:0006805,GO:0042376,GO:0050890,GO:0055114,GO:0070402" 3-keto sterol reductase activity|carbonyl reductase (NADPH) activity|protein binding|extracellular space|nucleoplasm|cytosol|xenobiotic metabolic process|phylloquinone catabolic process|cognition|oxidation-reduction process|NADPH binding "hsa00590,hsa00980" Arachidonic acid metabolism|Metabolism of xenobiotics by cytochrome P450 CBR4 394.9814213 430.3413306 359.621512 0.835665753 -0.259002082 0.55384557 1 4.84662447 4.224622471 84869 carbonyl reductase 4 "GO:0003955,GO:0005515,GO:0005759,GO:0006633,GO:0008753,GO:0016616,GO:0044597,GO:0044598,GO:0046949,GO:0047025,GO:0048038,GO:0051289,GO:0051290,GO:0055114,GO:0070402,GO:1990204" "NAD(P)H dehydrogenase (quinone) activity|protein binding|mitochondrial matrix|fatty acid biosynthetic process|NADPH dehydrogenase (quinone) activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|daunorubicin metabolic process|doxorubicin metabolic process|fatty-acyl-CoA biosynthetic process|3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity|quinone binding|protein homotetramerization|protein heterotetramerization|oxidation-reduction process|NADPH binding|oxidoreductase complex" hsa00061 Fatty acid biosynthesis CBS 183.889385 144.1237475 223.6550226 1.551826305 0.633967087 0.253155164 1 2.109641437 3.414818977 875 cystathionine beta-synthase "GO:0004122,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006535,GO:0006563,GO:0006565,GO:0019343,GO:0019344,GO:0019346,GO:0019448,GO:0019825,GO:0019899,GO:0020037,GO:0030170,GO:0031625,GO:0042262,GO:0042802,GO:0042803,GO:0043418,GO:0046872,GO:0050421,GO:0050667,GO:0055114,GO:0070025,GO:0070026,GO:0070814,GO:0072341,GO:1904047" cystathionine beta-synthase activity|protein binding|nucleus|cytoplasm|cytosol|cysteine biosynthetic process from serine|L-serine metabolic process|L-serine catabolic process|cysteine biosynthetic process via cystathionine|cysteine biosynthetic process|transsulfuration|L-cysteine catabolic process|oxygen binding|enzyme binding|heme binding|pyridoxal phosphate binding|ubiquitin protein ligase binding|DNA protection|identical protein binding|protein homodimerization activity|homocysteine catabolic process|metal ion binding|nitrite reductase (NO-forming) activity|homocysteine metabolic process|oxidation-reduction process|carbon monoxide binding|nitric oxide binding|hydrogen sulfide biosynthetic process|modified amino acid binding|S-adenosyl-L-methionine binding "hsa00260,hsa00270" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism" CBSL 154.655338 199.9463258 109.3643502 0.546968542 -0.870470234 0.138520345 1 2.590579696 1.47800273 102724560 cystathionine beta-synthase like "GO:0004122,GO:0005515,GO:0005634,GO:0005737,GO:0006535,GO:0019343,GO:0019346,GO:0020037,GO:0030170,GO:0046872,GO:0070814" cystathionine beta-synthase activity|protein binding|nucleus|cytoplasm|cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|transsulfuration|heme binding|pyridoxal phosphate binding|metal ion binding|hydrogen sulfide biosynthetic process "hsa00260,hsa00270" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism" CBWD1 171.1942706 219.2304892 123.1580521 0.561774288 -0.831937499 0.143082668 1 3.590960827 2.104206974 55871 COBW domain containing 1 "GO:0005515,GO:0005524,GO:0005737" protein binding|ATP binding|cytoplasm CBWD2 152.0909781 159.348087 144.8338692 0.908915017 -0.137782685 0.824603603 1 2.575117569 2.441384992 150472 COBW domain containing 2 "GO:0005524,GO:0005737" ATP binding|cytoplasm CBWD3 36.98923135 36.53841486 37.44004783 1.024676302 0.035168231 1 1 0.961820069 1.028007911 445571 COBW domain containing 3 "GO:0005515,GO:0005524,GO:0005737" protein binding|ATP binding|cytoplasm CBWD5 311.5390262 350.1598091 272.9182434 0.779410533 -0.359544667 0.44305839 1 5.009705944 4.072812669 220869 COBW domain containing 5 "GO:0005524,GO:0005737" ATP binding|cytoplasm CBWD6 92.48792414 92.36099312 92.61485516 1.002748585 0.00395993 1 1 1.487363584 1.555697421 644019 COBW domain containing 6 "GO:0005524,GO:0005737" ATP binding|cytoplasm CBX1 2808.51058 2762.710146 2854.311015 1.033156163 0.047058337 0.88349281 1 53.52774393 57.68472676 10951 chromobox 1 "GO:0000775,GO:0000781,GO:0000785,GO:0000792,GO:0001939,GO:0001940,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0005819,GO:0006974,GO:0010369,GO:0019899,GO:0042802,GO:0045892,GO:0090734,GO:1990226" "chromosome, centromeric region|chromosome, telomeric region|chromatin|heterochromatin|female pronucleus|male pronucleus|chromatin binding|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|spindle|cellular response to DNA damage stimulus|chromocenter|enzyme binding|identical protein binding|negative regulation of transcription, DNA-templated|site of DNA damage|histone methyltransferase binding" CBX2 281.7314372 299.4120107 264.0508636 0.881898034 -0.181316235 0.711656062 1 2.332589152 2.145717562 84733 chromobox 2 "GO:0000122,GO:0000791,GO:0000792,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0030154,GO:0031519,GO:0035064,GO:0035102,GO:0045137" negative regulation of transcription by RNA polymerase II|euchromatin|heterochromatin|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|chromatin organization|cell differentiation|PcG protein complex|methylated histone binding|PRC1 complex|development of primary sexual characteristics other CBX3 2607.088833 2699.782876 2514.394791 0.931332224 -0.102632198 0.748201072 1 50.41831799 48.97888709 11335 chromobox 3 "GO:0000775,GO:0000779,GO:0000781,GO:0000785,GO:0000791,GO:0000792,GO:0005515,GO:0005634,GO:0005635,GO:0005637,GO:0005654,GO:0005721,GO:0005819,GO:0006338,GO:0006974,GO:0008134,GO:0019899,GO:0019904,GO:0035985,GO:0042802,GO:0045892,GO:0048511,GO:0070317,GO:0071549,GO:0090575,GO:0090734,GO:1990226" "chromosome, centromeric region|condensed chromosome, centromeric region|chromosome, telomeric region|chromatin|euchromatin|heterochromatin|protein binding|nucleus|nuclear envelope|nuclear inner membrane|nucleoplasm|pericentric heterochromatin|spindle|chromatin remodeling|cellular response to DNA damage stimulus|transcription factor binding|enzyme binding|protein domain specific binding|senescence-associated heterochromatin focus|identical protein binding|negative regulation of transcription, DNA-templated|rhythmic process|negative regulation of G0 to G1 transition|cellular response to dexamethasone stimulus|RNA polymerase II transcription regulator complex|site of DNA damage|histone methyltransferase binding" hsa05131 Shigellosis chromosome_remodelling_factor CBX4 473.2357136 425.2665507 521.2048764 1.225595748 0.293483197 0.48007159 1 4.75878271 6.083577574 8535 chromobox 4 "GO:0000122,GO:0000976,GO:0003682,GO:0003714,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0016604,GO:0016607,GO:0016925,GO:0019789,GO:0019899,GO:0031519,GO:0032183,GO:0035064,GO:0035102,GO:0043066,GO:0045892,GO:0051219,GO:0061665" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|chromatin binding|transcription corepressor activity|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|nuclear body|nuclear speck|protein sumoylation|SUMO transferase activity|enzyme binding|PcG protein complex|SUMO binding|methylated histone binding|PRC1 complex|negative regulation of apoptotic process|negative regulation of transcription, DNA-templated|phosphoprotein binding|SUMO ligase activity" chromosome_remodelling_factor CBX5 5176.286057 4526.703619 5825.868495 1.287000207 0.364012286 0.258027332 1 19.32576659 25.94366193 23468 chromobox 5 "GO:0000118,GO:0000122,GO:0000776,GO:0000781,GO:0000792,GO:0003682,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005721,GO:0005730,GO:0006974,GO:0007596,GO:0010369,GO:0016032,GO:0016605,GO:0017053,GO:0030674,GO:0032991,GO:0035064,GO:0035097,GO:0042802,GO:0042826,GO:0043021,GO:0044877,GO:0045892,GO:0070317,GO:0070491,GO:0090734,GO:1990904" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|kinetochore|chromosome, telomeric region|heterochromatin|chromatin binding|protein binding|nucleus|nuclear envelope|nucleoplasm|pericentric heterochromatin|nucleolus|cellular response to DNA damage stimulus|blood coagulation|chromocenter|viral process|PML body|transcription repressor complex|protein-macromolecule adaptor activity|protein-containing complex|methylated histone binding|histone methyltransferase complex|identical protein binding|histone deacetylase binding|ribonucleoprotein complex binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|negative regulation of G0 to G1 transition|repressing transcription factor binding|site of DNA damage|ribonucleoprotein complex" CBX6 2179.321019 2318.159432 2040.482607 0.880216683 -0.184069378 0.566257332 1 19.39963603 17.81144308 23466 chromobox 6 "GO:0000122,GO:0000792,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0031519" negative regulation of transcription by RNA polymerase II|heterochromatin|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|PcG protein complex CBX7 460.6460034 305.5017465 615.7902603 2.015668543 1.011258422 0.016035094 0.5587138 3.763703652 7.913169501 23492 chromobox 7 "GO:0000122,GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006325,GO:0031519,GO:0035102" negative regulation of transcription by RNA polymerase II|chromatin|protein binding|nucleus|nucleoplasm|cytosol|chromatin organization|PcG protein complex|PRC1 complex CBX8 149.1351849 159.348087 138.9222827 0.871816445 -0.197903678 0.746664685 1 2.150964409 1.956024143 57332 chromobox 8 "GO:0000122,GO:0000785,GO:0000792,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0008284,GO:0016574,GO:0031519,GO:0032967,GO:0035064,GO:0035102,GO:0045739,GO:0050790,GO:0070301,GO:0097027" negative regulation of transcription by RNA polymerase II|chromatin|heterochromatin|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|positive regulation of cell population proliferation|histone ubiquitination|PcG protein complex|positive regulation of collagen biosynthetic process|methylated histone binding|PRC1 complex|positive regulation of DNA repair|regulation of catalytic activity|cellular response to hydrogen peroxide|ubiquitin-protein transferase activator activity chromosome_remodelling_factor CBY1 543.3297801 535.8967513 550.7628088 1.027740526 0.039476072 0.926139687 1 21.10519434 22.62500934 25776 "chibby family member 1, beta catenin antagonist" "GO:0005515,GO:0005634,GO:0005654,GO:0005802,GO:0005814,GO:0005829,GO:0008013,GO:0008104,GO:0016607,GO:0030030,GO:0030178,GO:0042802,GO:0042803,GO:0042995,GO:0045444,GO:0045892,GO:0051289,GO:0055007" "protein binding|nucleus|nucleoplasm|trans-Golgi network|centriole|cytosol|beta-catenin binding|protein localization|nuclear speck|cell projection organization|negative regulation of Wnt signaling pathway|identical protein binding|protein homodimerization activity|cell projection|fat cell differentiation|negative regulation of transcription, DNA-templated|protein homotetramerization|cardiac muscle cell differentiation" hsa04310 Wnt signaling pathway CBY2 7.015617123 8.119647747 5.911586499 0.728059478 -0.457871781 0.855058357 1 0.136034242 0.103307305 220082 chibby family member 2 "GO:0005515,GO:0031410" protein binding|cytoplasmic vesicle CC2D1A 763.5524607 705.394398 821.7105234 1.164895165 0.220200125 0.553873451 1 9.833674037 11.94864287 54862 coiled-coil and C2 domain containing 1A "GO:0000978,GO:0000981,GO:0001227,GO:0001650,GO:0005515,GO:0005634,GO:0005815,GO:0005829,GO:0005886,GO:0006357,GO:0016020,GO:0043123,GO:0045296,GO:0070062,GO:1905381" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleus|microtubule organizing center|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|cadherin binding|extracellular exosome|negative regulation of snRNA transcription by RNA polymerase II" CC2D1B 1443.011788 1622.914593 1263.108982 0.778296644 -0.361607958 0.277872171 1 10.12626572 8.220730427 200014 coiled-coil and C2 domain containing 1B "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0043231" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|intracellular membrane-bounded organelle" CC2D2A 405.0621953 378.5785762 431.5458144 1.139910818 0.188920958 0.665107139 1 2.505706918 2.979319486 57545 coiled-coil and C2 domain containing 2A "GO:0005829,GO:0005856,GO:0007224,GO:0035869,GO:0036038,GO:0060271,GO:0097711" cytosol|cytoskeleton|smoothened signaling pathway|ciliary transition zone|MKS complex|cilium assembly|ciliary basal body-plasma membrane docking CC2D2B 6.552676467 10.14955968 2.95579325 0.291223791 -1.779799875 0.306941875 1 0.054586322 0.016581607 387707 coiled-coil and C2 domain containing 2B CCAR1 2402.837978 2914.953541 1890.722415 0.648628662 -0.624535319 0.05105686 1 31.69431377 21.44338872 55749 cell division cycle and apoptosis regulator 1 "GO:0000398,GO:0000978,GO:0003713,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005641,GO:0005654,GO:0006355,GO:0006915,GO:0007049,GO:0008284,GO:0030335,GO:0030374,GO:0043065,GO:0045892,GO:0045893,GO:0048471" "mRNA splicing, via spliceosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription coactivator activity|transcription corepressor activity|RNA binding|protein binding|nucleus|nuclear envelope lumen|nucleoplasm|regulation of transcription, DNA-templated|apoptotic process|cell cycle|positive regulation of cell population proliferation|positive regulation of cell migration|nuclear receptor coactivator activity|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm" CCAR2 2149.84548 2222.753571 2076.93739 0.934398404 -0.097890284 0.761199855 1 21.97864642 21.42145472 57805 cell cycle and apoptosis regulator 2 "GO:0000785,GO:0000993,GO:0003723,GO:0004857,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005819,GO:0006355,GO:0006397,GO:0006974,GO:0007049,GO:0008380,GO:0009411,GO:0016055,GO:0019899,GO:0030308,GO:0030374,GO:0031647,GO:0032435,GO:0032784,GO:0042752,GO:0043065,GO:0043086,GO:0043653,GO:0044609,GO:0045892,GO:0045893,GO:0048511,GO:0090263,GO:0090311,GO:1900034,GO:1902230,GO:2000003" "chromatin|RNA polymerase II complex binding|RNA binding|enzyme inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|spindle|regulation of transcription, DNA-templated|mRNA processing|cellular response to DNA damage stimulus|cell cycle|RNA splicing|response to UV|Wnt signaling pathway|enzyme binding|negative regulation of cell growth|nuclear receptor coactivator activity|regulation of protein stability|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA-templated transcription, elongation|regulation of circadian rhythm|positive regulation of apoptotic process|negative regulation of catalytic activity|mitochondrial fragmentation involved in apoptotic process|DBIRD complex|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|rhythmic process|positive regulation of canonical Wnt signaling pathway|regulation of protein deacetylation|regulation of cellular response to heat|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of DNA damage checkpoint" CCBE1 454.9637845 422.2216828 487.7058862 1.155094364 0.208010716 0.621754058 1 2.965474792 3.572955698 147372 collagen and calcium binding EGF domains 1 "GO:0001946,GO:0002020,GO:0002040,GO:0003016,GO:0005509,GO:0005515,GO:0005518,GO:0005581,GO:0005615,GO:0010575,GO:0010595,GO:0010954,GO:0030324,GO:0031012,GO:0045766,GO:0048845,GO:1900748,GO:1901492" lymphangiogenesis|protease binding|sprouting angiogenesis|respiratory system process|calcium ion binding|protein binding|collagen binding|collagen trimer|extracellular space|positive regulation of vascular endothelial growth factor production|positive regulation of endothelial cell migration|positive regulation of protein processing|lung development|extracellular matrix|positive regulation of angiogenesis|venous blood vessel morphogenesis|positive regulation of vascular endothelial growth factor signaling pathway|positive regulation of lymphangiogenesis CCDC102A 312.2773557 265.9184637 358.6362476 1.348669974 0.431537357 0.356264245 1 3.561976219 5.010864213 92922 coiled-coil domain containing 102A "GO:0003774,GO:0016459" motor activity|myosin complex CCDC102B 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.016532851 0.003348107 79839 coiled-coil domain containing 102B GO:0005515 protein binding CCDC103 154.3287309 177.6172945 131.0401674 0.737766938 -0.438762958 0.457178936 1 2.600661858 2.001331389 388389 coiled-coil domain containing 103 "GO:0001947,GO:0003341,GO:0003351,GO:0005515,GO:0005576,GO:0005737,GO:0005930,GO:0007368,GO:0031514,GO:0036157,GO:0036158,GO:0036159,GO:0042803,GO:0060287,GO:0070286,GO:0071907" heart looping|cilium movement|epithelial cilium movement involved in extracellular fluid movement|protein binding|extracellular region|cytoplasm|axoneme|determination of left/right symmetry|motile cilium|outer dynein arm|outer dynein arm assembly|inner dynein arm assembly|protein homodimerization activity|epithelial cilium movement involved in determination of left/right asymmetry|axonemal dynein complex assembly|determination of digestive tract left/right asymmetry CCDC106 429.8934818 493.2686006 366.518363 0.743040126 -0.428487974 0.313796606 1 8.632451443 6.690558016 29903 coiled-coil domain containing 106 "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol CCDC107 482.7805558 538.9416192 426.6194924 0.79158758 -0.337179117 0.414221913 1 21.59453461 17.8303041 203260 coiled-coil domain containing 107 "GO:0005515,GO:0016021" protein binding|integral component of membrane CCDC110 21.48010047 20.29911937 22.66108158 1.116357866 0.15879958 0.927935429 1 0.283842845 0.330519676 256309 coiled-coil domain containing 110 "GO:0005515,GO:0005634,GO:0005856" protein binding|nucleus|cytoskeleton CCDC112 138.0152066 140.0639236 135.9664895 0.970745971 -0.042834281 0.956733701 1 2.562768647 2.594961558 153733 coiled-coil domain containing 112 GO:0005515 protein binding CCDC113 121.669269 133.9741878 109.3643502 0.816309112 -0.292812534 0.651529949 1 0.891280702 0.758900916 29070 coiled-coil domain containing 113 "GO:0005515,GO:0005930,GO:0032991,GO:0034451,GO:0036064,GO:0060271" protein binding|axoneme|protein-containing complex|centriolar satellite|ciliary basal body|cilium assembly CCDC115 287.7766356 308.5466144 267.0066569 0.865368941 -0.208612753 0.66727902 1 6.835869436 6.170366957 84317 coiled-coil domain containing 115 "GO:0005515,GO:0005764,GO:0005768,GO:0005783,GO:0005793,GO:0006879,GO:0007042,GO:0016020,GO:0016471,GO:0030137,GO:0036295,GO:0042406,GO:0051082,GO:0070072,GO:1905146" protein binding|lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cellular iron ion homeostasis|lysosomal lumen acidification|membrane|vacuolar proton-transporting V-type ATPase complex|COPI-coated vesicle|cellular response to increased oxygen levels|extrinsic component of endoplasmic reticulum membrane|unfolded protein binding|vacuolar proton-transporting V-type ATPase complex assembly|lysosomal protein catabolic process CCDC116 6.030352707 8.119647747 3.941057666 0.485372985 -1.042834281 0.589955466 1 0.115937839 0.058697112 164592 coiled-coil domain containing 116 "GO:0005515,GO:0005737,GO:0005813" protein binding|cytoplasm|centrosome CCDC117 991.1591813 941.8791387 1040.439224 1.104641966 0.143578843 0.685715813 1 11.75816012 13.54805149 150275 coiled-coil domain containing 117 GO:0005515 protein binding CCDC12 515.5196898 520.6724118 510.3669678 0.980207432 -0.028841009 0.948373136 1 3.548199789 3.627788724 151903 coiled-coil domain containing 12 "GO:0005515,GO:0005684,GO:0071014" protein binding|U2-type spliceosomal complex|post-mRNA release spliceosomal complex hsa03040 Spliceosome CCDC120 19.31657655 7.104691779 31.52846133 4.437695865 2.149810797 0.066345998 1 0.09454219 0.437621975 90060 coiled-coil domain containing 120 "GO:0005515,GO:0005768,GO:0005814,GO:0007275,GO:0008104,GO:0030426,GO:0034454,GO:0120103" protein binding|endosome|centriole|multicellular organism development|protein localization|growth cone|microtubule anchoring at centrosome|centriolar subdistal appendage CCDC121 12.06070541 16.23929549 7.882115332 0.485372985 -1.042834281 0.44253226 1 0.283314856 0.143436896 79635 coiled-coil domain containing 121 GO:0005515 protein binding CCDC122 48.88663322 41.6131947 56.16007174 1.349573666 0.432503728 0.624174579 1 0.414303422 0.58321817 160857 coiled-coil domain containing 122 CCDC124 1102.78677 1197.648043 1007.925498 0.841587396 -0.248814996 0.473421871 1 56.00798552 49.16602583 115098 coiled-coil domain containing 124 "GO:0003723,GO:0005815,GO:0005829,GO:0005886,GO:0007049,GO:0030496,GO:0051301" RNA binding|microtubule organizing center|cytosol|plasma membrane|cell cycle|midbody|cell division CCDC125 360.1705597 408.0122993 312.32882 0.765488738 -0.385546942 0.389355488 1 3.977744673 3.176081501 202243 coiled-coil domain containing 125 "GO:0003674,GO:0005515,GO:0005737,GO:0035024,GO:0042802,GO:0090630,GO:2000146" molecular_function|protein binding|cytoplasm|negative regulation of Rho protein signal transduction|identical protein binding|activation of GTPase activity|negative regulation of cell motility CCDC126 74.56016955 79.16656553 69.95377357 0.883627742 -0.178489381 0.826110708 1 1.450093042 1.336537477 90693 coiled-coil domain containing 126 "GO:0005576,GO:0016020" extracellular region|membrane CCDC127 724.5899789 702.3495301 746.8304277 1.063331569 0.088591529 0.816195924 1 3.831899813 4.250096422 133957 coiled-coil domain containing 127 CCDC130 306.6599631 319.71113 293.6087961 0.918356505 -0.122873779 0.799092411 1 7.925717505 7.592168274 81576 coiled-coil domain containing 130 "GO:0005515,GO:0005575,GO:0005684,GO:0008380,GO:0009615,GO:0071014" protein binding|cellular_component|U2-type spliceosomal complex|RNA splicing|response to virus|post-mRNA release spliceosomal complex CCDC134 681.2856035 671.9008511 690.670356 1.027934933 0.039748946 0.920574136 1 4.717788407 5.058479725 79879 coiled-coil domain containing 134 "GO:0001525,GO:0001890,GO:0005515,GO:0005576,GO:0005634,GO:0005783,GO:0016020,GO:0021591,GO:0035162,GO:1990402" angiogenesis|placenta development|protein binding|extracellular region|nucleus|endoplasmic reticulum|membrane|ventricular system development|embryonic hemopoiesis|embryonic liver development CCDC136 621.1238533 499.3583364 742.8893701 1.48768793 0.573071927 0.139844916 1 4.835705184 7.503909452 64753 coiled-coil domain containing 136 "GO:0001675,GO:0002080,GO:0007283,GO:0007338,GO:0016021" acrosome assembly|acrosomal membrane|spermatogenesis|single fertilization|integral component of membrane CCDC137 871.867958 936.8043588 806.9315572 0.861366143 -0.215301477 0.552220588 1 17.87037135 16.05599796 339230 coiled-coil domain containing 137 "GO:0001650,GO:0003723,GO:0005515,GO:0005694,GO:0005730" fibrillar center|RNA binding|protein binding|chromosome|nucleolus CCDC138 152.7145007 201.9762377 103.4527637 0.512202648 -0.965213384 0.102272254 1 1.937383316 1.03507854 165055 coiled-coil domain containing 138 CCDC14 1252.71843 1108.331917 1397.104943 1.260547423 0.334050395 0.325780397 1 6.610894083 8.692312229 64770 coiled-coil domain containing 14 "GO:0005515,GO:0005737,GO:0005813,GO:0021762,GO:0034451,GO:0071539" protein binding|cytoplasm|centrosome|substantia nigra development|centriolar satellite|protein localization to centrosome CCDC142 285.0583748 324.7859099 245.3308397 0.755361708 -0.404760444 0.400792614 1 3.984801492 3.13962361 84865 coiled-coil domain containing 142 CCDC146 30.4217091 25.37389921 35.469519 1.397874198 0.48323453 0.640343159 1 0.385336876 0.56185544 57639 coiled-coil domain containing 146 "GO:0005515,GO:0005737,GO:0005814,GO:0005856" protein binding|cytoplasm|centriole|cytoskeleton CCDC148 4.52276453 6.08973581 2.95579325 0.485372985 -1.042834281 0.660953233 1 0.081766605 0.041396869 130940 coiled-coil domain containing 148 GO:0005515 protein binding CCDC149 26.76544278 11.16451565 42.36636991 3.794734248 1.923998855 0.066825401 1 0.081020681 0.320695736 91050 coiled-coil domain containing 149 CCDC15 188.1597714 132.9592319 243.3603109 1.830337822 0.872109949 0.113645549 1 1.20291462 2.296582161 80071 coiled-coil domain containing 15 GO:0005813 centrosome CCDC150 87.51706473 89.31612522 85.71800424 0.959714766 -0.059322404 0.950432398 1 0.847741127 0.848635821 284992 coiled-coil domain containing 150 GO:0005515 protein binding CCDC153 13.47921893 12.17947162 14.77896625 1.213432463 0.279093814 0.880229941 1 0.456923904 0.578329597 283152 coiled-coil domain containing 153 GO:0005515 protein binding CCDC157 50.03520117 52.77771036 47.29269199 0.896073204 -0.158311499 0.873663594 1 0.800300851 0.748019119 550631 coiled-coil domain containing 157 GO:0005515 protein binding CCDC159 20.56906494 25.37389921 15.76423066 0.621277421 -0.686690471 0.550355126 1 0.74715028 0.484182918 126075 coiled-coil domain containing 159 CCDC163 136.1040608 144.1237475 128.0843742 0.8887111 -0.170213588 0.790152723 1 3.232665799 2.996659115 126661 coiled-coil domain containing 163 GO:0016021 integral component of membrane CCDC167 160.6559992 206.0360616 115.2759367 0.559493983 -0.837805479 0.148694292 1 18.24300641 10.64652212 154467 coiled-coil domain containing 167 "GO:0005515,GO:0016021" protein binding|integral component of membrane CCDC168 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.01445081 0.004877446 643677 coiled-coil domain containing 168 CCDC169 7.941498436 4.059823873 11.823173 2.912237912 1.542128219 0.334285655 1 0.031458959 0.095562418 728591 coiled-coil domain containing 169 CCDC17 14.55355801 18.26920743 10.83790858 0.593233649 -0.753327664 0.562628766 1 0.280470114 0.17355147 149483 coiled-coil domain containing 17 GO:0005515 protein binding CCDC170 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.046790405 0.009475635 80129 coiled-coil domain containing 170 "GO:0000226,GO:0005515,GO:0005794,GO:0008017,GO:0036064" microtubule cytoskeleton organization|protein binding|Golgi apparatus|microtubule binding|ciliary basal body CCDC171 46.90125861 40.59823873 53.20427849 1.31050706 0.390125126 0.665638257 1 0.150678409 0.205971115 203238 coiled-coil domain containing 171 CCDC173 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.117307027 0.071268367 129881 coiled-coil domain containing 173 CCDC174 434.5013616 370.4589285 498.5437948 1.345746469 0.42840664 0.312552036 1 5.294141599 7.431470044 51244 coiled-coil domain containing 174 "GO:0005515,GO:0005634,GO:0005654" protein binding|nucleus|nucleoplasm CCDC18 378.3412899 370.4589285 386.2236513 1.042554577 0.060122909 0.897306756 1 1.73069254 1.882065139 343099 coiled-coil domain containing 18 CCDC180 164.6470374 142.0938356 187.2002391 1.31744096 0.39773831 0.491691234 1 0.960693031 1.320175691 100499483 coiled-coil domain containing 180 GO:0070062 extracellular exosome CCDC183 17.52419703 19.2841634 15.76423066 0.817470291 -0.290761795 0.8448714 1 0.569157836 0.48531155 84960 coiled-coil domain containing 183 CCDC184 4.97085941 3.044867905 6.896850916 2.265073931 1.17955814 0.582594813 1 0.067547883 0.15959161 387856 coiled-coil domain containing 184 "GO:0005515,GO:0005737" protein binding|cytoplasm CCDC186 317.8987076 347.1149412 288.682474 0.831662484 -0.265929942 0.569491065 1 2.025362583 1.756975975 55088 coiled-coil domain containing 186 "GO:0005794,GO:0009617,GO:0035773,GO:0099518" Golgi apparatus|response to bacterium|insulin secretion involved in cellular response to glucose stimulus|vesicle cytoskeletal trafficking CCDC188 117.7160872 99.4656849 135.9664895 1.366968816 0.450980331 0.486103278 1 2.831695361 4.037579309 388849 coiled-coil domain containing 188 GO:0016021 integral component of membrane CCDC189 110.967694 109.6152446 112.3201435 1.024676302 0.035168231 0.972373064 1 2.934262917 3.136184811 90835 coiled-coil domain containing 189 CCDC191 128.0437962 131.9442759 124.1433165 0.940876864 -0.087922171 0.900217061 1 0.928126681 0.910869115 57577 coiled-coil domain containing 191 CCDC192 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.037763693 0.007647614 728586 coiled-coil domain containing 192 CCDC194 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.193830842 0.15701256 110806280 CCDC22 581.6160371 593.7492415 569.4828328 0.959130207 -0.060201413 0.882606389 1 13.00099631 13.00679015 28952 coiled-coil domain containing 22 "GO:0005515,GO:0005575,GO:0005654,GO:0005768,GO:0005829,GO:0006878,GO:0006893,GO:0007253,GO:0015031,GO:0016567,GO:0032456,GO:0043123,GO:0043124,GO:0043687,GO:0097602,GO:1990126,GO:2000060" "protein binding|cellular_component|nucleoplasm|endosome|cytosol|cellular copper ion homeostasis|Golgi to plasma membrane transport|cytoplasmic sequestering of NF-kappaB|protein transport|protein ubiquitination|endocytic recycling|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|post-translational protein modification|cullin family protein binding|retrograde transport, endosome to plasma membrane|positive regulation of ubiquitin-dependent protein catabolic process" CCDC24 147.1795018 160.363043 133.9959607 0.83557881 -0.259152188 0.670127327 1 5.375130643 4.684814205 149473 coiled-coil domain containing 24 "GO:0001835,GO:0005515" blastocyst hatching|protein binding CCDC25 628.1461513 608.973581 647.3187217 1.062966838 0.088096589 0.823274603 1 8.349313359 9.257344087 55246 coiled-coil domain containing 25 GO:0005515 protein binding CCDC28A 213.4297501 176.6023385 250.2571618 1.417065957 0.50290691 0.341654026 1 4.335572191 6.408441387 25901 coiled-coil domain containing 28A GO:0005515 protein binding CCDC28B 191.7512114 210.0958855 173.4065373 0.825368555 -0.27688962 0.616801413 1 5.417828627 4.664328316 79140 coiled-coil domain containing 28B "GO:0005515,GO:0005737,GO:0005813,GO:0060271" protein binding|cytoplasm|centrosome|cilium assembly CCDC3 4.493072978 4.059823873 4.926322083 1.213432463 0.279093814 1 1 0.05094543 0.064481744 83643 coiled-coil domain containing 3 "GO:0005576,GO:0005783,GO:0010629,GO:0010804,GO:0045600,GO:0045833,GO:0046889,GO:0051055" extracellular region|endoplasmic reticulum|negative regulation of gene expression|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of fat cell differentiation|negative regulation of lipid metabolic process|positive regulation of lipid biosynthetic process|negative regulation of lipid biosynthetic process CCDC30 8.538051076 11.16451565 5.911586499 0.529497802 -0.917303399 0.571398598 1 0.069116652 0.038173571 728621 coiled-coil domain containing 30 CCDC32 224.7427236 209.0809295 240.4045176 1.149815616 0.201402529 0.703275886 1 2.344820967 2.812249323 90416 coiled-coil domain containing 32 GO:0005515 protein binding CCDC34 320.753302 306.5167024 334.9899016 1.092892814 0.128151916 0.787191968 1 5.325553912 6.070972782 91057 coiled-coil domain containing 34 CCDC38 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.074520063 0.0452737 120935 coiled-coil domain containing 38 "GO:0005737,GO:0005813" cytoplasm|centrosome CCDC39 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.053434448 0.01352642 339829 coiled-coil domain containing 39 "GO:0001947,GO:0003341,GO:0003356,GO:0005576,GO:0005829,GO:0005929,GO:0005930,GO:0007420,GO:0030317,GO:0030324,GO:0035469,GO:0036159,GO:0044458,GO:0051649,GO:0060285,GO:0060287,GO:0061512,GO:0061966,GO:0070286,GO:0071907,GO:0071910,GO:0090660" heart looping|cilium movement|regulation of cilium beat frequency|extracellular region|cytosol|cilium|axoneme|brain development|flagellated sperm motility|lung development|determination of pancreatic left/right asymmetry|inner dynein arm assembly|motile cilium assembly|establishment of localization in cell|cilium-dependent cell motility|epithelial cilium movement involved in determination of left/right asymmetry|protein localization to cilium|establishment of left/right asymmetry|axonemal dynein complex assembly|determination of digestive tract left/right asymmetry|determination of liver left/right asymmetry|cerebrospinal fluid circulation CCDC40 25.10667524 32.47859099 17.7347595 0.546044608 -0.87290928 0.408830722 1 0.200551823 0.114227499 55036 coiled-coil domain containing 40 "GO:0001947,GO:0003341,GO:0003351,GO:0003356,GO:0003674,GO:0005576,GO:0005737,GO:0005929,GO:0005930,GO:0030317,GO:0030324,GO:0035082,GO:0035469,GO:0036159,GO:0044458,GO:0060287,GO:0070286,GO:0071907,GO:0071910" heart looping|cilium movement|epithelial cilium movement involved in extracellular fluid movement|regulation of cilium beat frequency|molecular_function|extracellular region|cytoplasm|cilium|axoneme|flagellated sperm motility|lung development|axoneme assembly|determination of pancreatic left/right asymmetry|inner dynein arm assembly|motile cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry|axonemal dynein complex assembly|determination of digestive tract left/right asymmetry|determination of liver left/right asymmetry CCDC43 508.1302066 520.6724118 495.5880015 0.951823047 -0.071234707 0.865445675 1 12.47408743 12.38456994 124808 coiled-coil domain containing 43 "GO:0005515,GO:0005829" protein binding|cytosol CCDC47 2172.313321 2580.018072 1764.60857 0.683952019 -0.548032974 0.087869416 1 37.67843529 26.88031941 57003 coiled-coil domain containing 47 "GO:0001649,GO:0003723,GO:0005509,GO:0005515,GO:0005783,GO:0006983,GO:0007029,GO:0009791,GO:0016020,GO:0016021,GO:0030433,GO:0030867,GO:0032469,GO:0036503" osteoblast differentiation|RNA binding|calcium ion binding|protein binding|endoplasmic reticulum|ER overload response|endoplasmic reticulum organization|post-embryonic development|membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|rough endoplasmic reticulum membrane|endoplasmic reticulum calcium ion homeostasis|ERAD pathway CCDC50 2810.200769 2170.990816 3449.410722 1.588864723 0.667996298 0.036453519 0.86078571 12.25786244 20.31503597 152137 coiled-coil domain containing 50 "GO:0005515,GO:0005829,GO:0007605,GO:0031625" protein binding|cytosol|sensory perception of sound|ubiquitin protein ligase binding CCDC51 303.1561139 450.64045 155.6717778 0.345445638 -1.533469399 0.001406648 0.112814853 10.40262034 3.748334943 79714 coiled-coil domain containing 51 "GO:0005515,GO:0031305,GO:0062156,GO:0062157,GO:0071805" protein binding|integral component of mitochondrial inner membrane|mitochondrial ATP-gated potassium channel activity|mitochondrial ATP-gated potassium channel complex|potassium ion transmembrane transport CCDC57 408.722421 527.7771036 289.6677385 0.548844837 -0.865529749 0.045339138 0.96408227 1.924409533 1.101699145 284001 coiled-coil domain containing 57 "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005876,GO:0007020,GO:0007099,GO:0034451,GO:0045931,GO:0060271" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|spindle microtubule|microtubule nucleation|centriole replication|centriolar satellite|positive regulation of mitotic cell cycle|cilium assembly CCDC59 444.3634083 438.4609783 450.2658384 1.026923399 0.038328572 0.933037075 1 14.0104112 15.00737938 29080 coiled-coil domain containing 59 "GO:0003723,GO:0005515,GO:0005654,GO:0044267" RNA binding|protein binding|nucleoplasm|cellular protein metabolic process CCDC6 1882.860596 1954.805195 1810.915998 0.926392053 -0.110305218 0.734306189 1 17.28723363 16.70460658 8030 coiled-coil domain containing 6 "GO:0005200,GO:0005515,GO:0005829,GO:0005856,GO:0007010,GO:0008150,GO:0017124,GO:0042802" structural constituent of cytoskeleton|protein binding|cytosol|cytoskeleton|cytoskeleton organization|biological_process|SH3 domain binding|identical protein binding "hsa05200,hsa05216" Pathways in cancer|Thyroid cancer CCDC61 155.3018712 143.1087915 167.4949508 1.170402943 0.227005302 0.705176153 1 1.512827267 1.846888506 729440 coiled-coil domain containing 61 "GO:0005515,GO:0005737,GO:0005813,GO:0005815,GO:0008017,GO:0030030,GO:0034451,GO:0036064,GO:0042802,GO:0090307,GO:0098534,GO:0120103" protein binding|cytoplasm|centrosome|microtubule organizing center|microtubule binding|cell projection organization|centriolar satellite|ciliary basal body|identical protein binding|mitotic spindle assembly|centriole assembly|centriolar subdistal appendage CCDC62 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.036769628 0.037231519 84660 coiled-coil domain containing 62 "GO:0001835,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0030331,GO:0030374,GO:0045944,GO:0071392" blastocyst hatching|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|estrogen receptor binding|nuclear receptor coactivator activity|positive regulation of transcription by RNA polymerase II|cellular response to estradiol stimulus CCDC66 174.2445817 158.3331311 190.1560324 1.200987002 0.264220537 0.644643894 1 2.138974266 2.679537235 285331 coiled-coil domain containing 66 "GO:0001578,GO:0001750,GO:0001895,GO:0001917,GO:0005515,GO:0005813,GO:0005829,GO:0005874,GO:0005929,GO:0008017,GO:0030054,GO:0034451,GO:0035869,GO:0036064,GO:0042803,GO:0050908,GO:0060271,GO:0090543,GO:1903564" microtubule bundle formation|photoreceptor outer segment|retina homeostasis|photoreceptor inner segment|protein binding|centrosome|cytosol|microtubule|cilium|microtubule binding|cell junction|centriolar satellite|ciliary transition zone|ciliary basal body|protein homodimerization activity|detection of light stimulus involved in visual perception|cilium assembly|Flemming body|regulation of protein localization to cilium CCDC68 348.9427015 246.6343003 451.2511028 1.829636438 0.871557003 0.054297127 1 2.747120571 5.242741583 80323 coiled-coil domain containing 68 "GO:0005515,GO:0005622,GO:0005737,GO:0005814,GO:0008104,GO:0034454,GO:0035556,GO:0120103" protein binding|intracellular anatomical structure|cytoplasm|centriole|protein localization|microtubule anchoring at centrosome|intracellular signal transduction|centriolar subdistal appendage CCDC69 680.4082189 813.9946866 546.8217512 0.671775578 -0.573948746 0.131244453 1 12.13241886 8.501342954 26112 coiled-coil domain containing 69 "GO:0005634,GO:0005737,GO:0008017,GO:0030496,GO:0051233,GO:0051255" nucleus|cytoplasm|microtubule binding|midbody|spindle midzone|spindle midzone assembly CCDC7 19.5986463 26.38885518 12.80843742 0.485372985 -1.042834281 0.359314235 1 0.177773666 0.090003409 79741 coiled-coil domain containing 7 CCDC71 509.9819693 512.552764 507.4111745 0.989968663 -0.014545237 0.976821282 1 14.49413139 14.96682122 64925 coiled-coil domain containing 71 CCDC71L 1742.987192 1350.906394 2135.067991 1.580470712 0.660354301 0.043343469 0.94601832 10.06304503 16.58944275 168455 coiled-coil domain containing 71 like "GO:0044255,GO:0045600" cellular lipid metabolic process|positive regulation of fat cell differentiation CCDC73 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.015141072 0.045993812 493860 coiled-coil domain containing 73 CCDC74A 156.4207476 152.2433953 160.5980999 1.054877288 0.077075182 0.905862723 1 2.717867778 2.990516456 90557 coiled-coil domain containing 74A GO:0005515 protein binding CCDC74B 20.52452761 22.3290313 18.72002391 0.83837152 -0.254338386 0.857316142 1 0.649934864 0.568358397 91409 coiled-coil domain containing 74B CCDC77 439.2913501 394.8178717 483.7648285 1.225286045 0.293118588 0.4893286 1 8.195136216 10.47392823 84318 coiled-coil domain containing 77 "GO:0005813,GO:0016020" centrosome|membrane CCDC78 20.52452761 22.3290313 18.72002391 0.83837152 -0.254338386 0.857316142 1 0.435291248 0.380655739 124093 coiled-coil domain containing 78 "GO:0003009,GO:0005814,GO:0016529,GO:0030030,GO:0042383,GO:0048471,GO:0098535,GO:0098536" skeletal muscle contraction|centriole|sarcoplasmic reticulum|cell projection organization|sarcolemma|perinuclear region of cytoplasm|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|deuterosome CCDC80 269.0593333 275.0530674 263.0655992 0.956417617 -0.064287391 0.902975335 1 1.132466266 1.129766703 151887 coiled-coil domain containing 80 "GO:0001968,GO:0005604,GO:0005614,GO:0008201,GO:0009617,GO:0010811,GO:0030198" fibronectin binding|basement membrane|interstitial matrix|heparin binding|response to bacterium|positive regulation of cell-substrate adhesion|extracellular matrix organization CCDC81 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.033722243 0.034145854 60494 coiled-coil domain containing 81 "GO:0005515,GO:0005737,GO:0005813" protein binding|cytoplasm|centrosome CCDC82 738.4485071 639.4222601 837.4747541 1.309736627 0.389276731 0.297455316 1 4.840729705 6.613185972 79780 coiled-coil domain containing 82 GO:0005634 nucleus CCDC85A 3.47811701 2.029911937 4.926322083 2.426864926 1.279093814 0.644064692 1 0.024402535 0.061772684 114800 coiled-coil domain containing 85A "GO:0005515,GO:0005912,GO:0008150" protein binding|adherens junction|biological_process CCDC85B 1394.227591 1790.382328 998.072854 0.557463531 -0.843050668 0.012178767 0.486935126 94.16048685 54.75213846 11007 coiled-coil domain containing 85B "GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005912,GO:0016032,GO:0030154,GO:0030308,GO:0045599,GO:0045892,GO:0070097" "protein binding|nucleus|cytoplasm|centrosome|adherens junction|viral process|cell differentiation|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|delta-catenin binding" CCDC85C 641.533574 648.5568638 634.5102843 0.978341792 -0.031589524 0.938829311 1 1.678185111 1.712562378 317762 coiled-coil domain containing 85C "GO:0005912,GO:0005923,GO:0021987,GO:0043296" adherens junction|bicellular tight junction|cerebral cortex development|apical junction complex CCDC86 829.2855824 1023.075616 635.4955487 0.621161856 -0.686958854 0.060151479 1 27.99306902 18.137241 79080 coiled-coil domain containing 86 "GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0016032" RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|viral process CCDC87 9.986256149 9.134603715 10.83790858 1.186467297 0.246672336 0.934370347 1 0.160192331 0.198250104 55231 coiled-coil domain containing 87 "GO:0005515,GO:0007283,GO:0007338,GO:0030154,GO:1905516,GO:2000344" protein binding|spermatogenesis|single fertilization|cell differentiation|positive regulation of fertilization|positive regulation of acrosome reaction CCDC88A 1626.786612 1523.448909 1730.124315 1.135662841 0.183534587 0.576845634 1 6.494176653 7.692888601 55704 coiled-coil domain containing 88A "GO:0001932,GO:0001965,GO:0003779,GO:0005080,GO:0005085,GO:0005092,GO:0005154,GO:0005158,GO:0005515,GO:0005737,GO:0005783,GO:0005794,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0006260,GO:0006275,GO:0007264,GO:0007399,GO:0008017,GO:0010975,GO:0016020,GO:0016477,GO:0030027,GO:0030032,GO:0030142,GO:0030705,GO:0031122,GO:0031410,GO:0031682,GO:0031929,GO:0032147,GO:0032148,GO:0032956,GO:0035091,GO:0036064,GO:0042127,GO:0042169,GO:0042803,GO:0043184,GO:0043422,GO:0045724,GO:0045742,GO:0051496,GO:0051959,GO:0061024,GO:0072660,GO:1903566" regulation of protein phosphorylation|G-protein alpha-subunit binding|actin binding|protein kinase C binding|guanyl-nucleotide exchange factor activity|GDP-dissociation inhibitor activity|epidermal growth factor receptor binding|insulin receptor binding|protein binding|cytoplasm|endoplasmic reticulum|Golgi apparatus|centrosome|centriole|cytosol|plasma membrane|DNA replication|regulation of DNA replication|small GTPase mediated signal transduction|nervous system development|microtubule binding|regulation of neuron projection development|membrane|cell migration|lamellipodium|lamellipodium assembly|COPI-coated Golgi to ER transport vesicle|cytoskeleton-dependent intracellular transport|cytoplasmic microtubule organization|cytoplasmic vesicle|G-protein gamma-subunit binding|TOR signaling|activation of protein kinase activity|activation of protein kinase B activity|regulation of actin cytoskeleton organization|phosphatidylinositol binding|ciliary basal body|regulation of cell population proliferation|SH2 domain binding|protein homodimerization activity|vascular endothelial growth factor receptor 2 binding|protein kinase B binding|positive regulation of cilium assembly|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of stress fiber assembly|dynein light intermediate chain binding|membrane organization|maintenance of protein location in plasma membrane|positive regulation of protein localization to cilium CCDC88B 41.74952829 58.86744617 24.63161041 0.418424987 -1.256959087 0.163290478 1 0.51617529 0.225284209 283234 coiled-coil domain containing 88B "GO:0001819,GO:0005515,GO:0005737,GO:0005783,GO:0005794,GO:0005813,GO:0008017,GO:0016020,GO:0030705,GO:0031122,GO:0042102,GO:0042832,GO:0050870,GO:0051959" positive regulation of cytokine production|protein binding|cytoplasm|endoplasmic reticulum|Golgi apparatus|centrosome|microtubule binding|membrane|cytoskeleton-dependent intracellular transport|cytoplasmic microtubule organization|positive regulation of T cell proliferation|defense response to protozoan|positive regulation of T cell activation|dynein light intermediate chain binding CCDC88C 291.893121 354.219633 229.5666091 0.648091149 -0.625731363 0.189872901 1 2.117560765 1.431488627 440193 coiled-coil domain containing 88C "GO:0001932,GO:0001965,GO:0003383,GO:0005085,GO:0005109,GO:0005515,GO:0005737,GO:0005813,GO:0007264,GO:0008017,GO:0030054,GO:0030165,GO:0030705,GO:0031098,GO:0031122,GO:0031648,GO:0035567,GO:0042802,GO:0043621,GO:0050790,GO:0051959,GO:0090090" regulation of protein phosphorylation|G-protein alpha-subunit binding|apical constriction|guanyl-nucleotide exchange factor activity|frizzled binding|protein binding|cytoplasm|centrosome|small GTPase mediated signal transduction|microtubule binding|cell junction|PDZ domain binding|cytoskeleton-dependent intracellular transport|stress-activated protein kinase signaling cascade|cytoplasmic microtubule organization|protein destabilization|non-canonical Wnt signaling pathway|identical protein binding|protein self-association|regulation of catalytic activity|dynein light intermediate chain binding|negative regulation of canonical Wnt signaling pathway CCDC9 293.5721775 266.9334197 320.2109354 1.199591028 0.262542637 0.584330588 1 6.109008596 7.643985858 26093 coiled-coil domain containing 9 "GO:0003723,GO:0005515" RNA binding|protein binding CCDC90B 740.3002697 631.3026123 849.2979271 1.345310332 0.427939008 0.251756415 1 7.355245045 10.32132738 60492 coiled-coil domain containing 90B "GO:0005515,GO:0005739,GO:0016021,GO:0031966" protein binding|mitochondrion|integral component of membrane|mitochondrial membrane CCDC91 316.8270901 307.5316584 326.1225219 1.060451869 0.084679142 0.86163031 1 4.808704413 5.319061033 55297 coiled-coil domain containing 91 "GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0015031,GO:0016020,GO:0042802,GO:0090160" nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|protein transport|membrane|identical protein binding|Golgi to lysosome transport CCDC92 561.5302018 500.3732924 622.6871113 1.244445139 0.315502631 0.427730257 1 5.311704475 6.89486218 80212 coiled-coil domain containing 92 "GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0042802,GO:0043231" protein binding|nucleoplasm|cytoplasm|centrosome|centriole|identical protein binding|intracellular membrane-bounded organelle CCDC93 1507.809872 1506.194657 1509.425086 1.002144762 0.003090924 0.994842398 1 8.287174997 8.662692537 54520 coiled-coil domain containing 93 "GO:0005515,GO:0005769,GO:0006893,GO:0015031,GO:0032456,GO:0043231,GO:1990126" "protein binding|early endosome|Golgi to plasma membrane transport|protein transport|endocytic recycling|intracellular membrane-bounded organelle|retrograde transport, endosome to plasma membrane" CCDC96 26.98812942 26.38885518 27.58740366 1.045418737 0.064080923 0.991192066 1 0.620762852 0.676911558 257236 coiled-coil domain containing 96 "GO:0005515,GO:0005930,GO:0036064,GO:0060271" protein binding|axoneme|ciliary basal body|cilium assembly CCDC97 499.428852 498.3433805 500.5143236 1.00435632 0.006271191 0.993345557 1 6.030904222 6.31809538 90324 coiled-coil domain containing 97 CCDC9B 2207.494089 2459.238311 1955.749867 0.795266509 -0.330489679 0.302397644 1 23.50476407 19.49775098 388115 coiled-coil domain containing 9B GO:0003723 RNA binding CCHCR1 480.9720927 381.6234441 580.3207413 1.520663236 0.604700691 0.143160114 1 5.864041613 9.301350705 54535 coiled-coil alpha-helical rod protein 1 "GO:0005515,GO:0005634,GO:0005814,GO:0005829,GO:0006611,GO:0007275,GO:0030154" protein binding|nucleus|centriole|cytosol|protein export from nucleus|multicellular organism development|cell differentiation CCIN 5.478337395 4.059823873 6.896850916 1.698805448 0.764520641 0.742562249 1 0.105606449 0.187132843 881 calicin "GO:0005515,GO:0005634,GO:0007283,GO:0007420,GO:0015629,GO:0030036,GO:0030154,GO:0032839,GO:0033150,GO:0051015" protein binding|nucleus|spermatogenesis|brain development|actin cytoskeleton|actin cytoskeleton organization|cell differentiation|dendrite cytoplasm|cytoskeletal calyx|actin filament binding CCL20 161.985438 195.8865019 128.0843742 0.653870343 -0.612923505 0.289346425 1 11.89563582 8.113256933 6364 C-C motif chemokine ligand 20 "GO:0002548,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0006955,GO:0007165,GO:0007186,GO:0007267,GO:0008009,GO:0019221,GO:0030593,GO:0031731,GO:0035584,GO:0042742,GO:0043547,GO:0048020,GO:0048247,GO:0060326,GO:0070098,GO:0070374,GO:0071346,GO:0071347,GO:0071356,GO:0072678,GO:0072679,GO:2000406" monocyte chemotaxis|protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|immune response|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|cytokine-mediated signaling pathway|neutrophil chemotaxis|CCR6 chemokine receptor binding|calcium-mediated signaling using intracellular calcium source|defense response to bacterium|positive regulation of GTPase activity|CCR chemokine receptor binding|lymphocyte chemotaxis|cell chemotaxis|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor|T cell migration|thymocyte migration|positive regulation of T cell migration "hsa04060,hsa04061,hsa04062,hsa04657,hsa04668,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Rheumatoid arthritis CCL28 5.015396738 6.08973581 3.941057666 0.64716398 -0.627796782 0.826813936 1 0.075798387 0.051167032 56477 C-C motif chemokine ligand 28 "GO:0001954,GO:0005515,GO:0005576,GO:0006935,GO:0006955,GO:0007186,GO:0007204,GO:0007584,GO:0008009,GO:0060326,GO:0070062,GO:1903237" positive regulation of cell-matrix adhesion|protein binding|extracellular region|chemotaxis|immune response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|response to nutrient|chemokine activity|cell chemotaxis|extracellular exosome|negative regulation of leukocyte tethering or rolling "hsa04060,hsa04061,hsa04062,hsa04672" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|Intestinal immune network for IgA production CCL3L3 3.970749218 2.029911937 5.911586499 2.912237912 1.542128219 0.515744462 1 0.131132498 0.398339263 414062 C-C motif chemokine ligand 3 like 3 "GO:0002548,GO:0005515,GO:0005576,GO:0005615,GO:0006954,GO:0007186,GO:0008009,GO:0008285,GO:0019221,GO:0030593,GO:0043547,GO:0048020,GO:0048247,GO:0070098,GO:0070374,GO:0071346,GO:0071347,GO:0071356" monocyte chemotaxis|protein binding|extracellular region|extracellular space|inflammatory response|G protein-coupled receptor signaling pathway|chemokine activity|negative regulation of cell population proliferation|cytokine-mediated signaling pathway|neutrophil chemotaxis|positive regulation of GTPase activity|CCR chemokine receptor binding|lymphocyte chemotaxis|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor "hsa04060,hsa04061,hsa04062,hsa04620,hsa05142,hsa05163,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|Toll-like receptor signaling pathway|Chagas disease|Human cytomegalovirus infection|Rheumatoid arthritis CCL5 5.537720498 8.119647747 2.95579325 0.364029739 -1.457871781 0.448526494 1 0.316575453 0.120207076 6352 C-C motif chemokine ligand 5 "GO:0000165,GO:0002407,GO:0002548,GO:0002676,GO:0004435,GO:0004672,GO:0005515,GO:0005576,GO:0005615,GO:0006468,GO:0006816,GO:0006874,GO:0006887,GO:0006935,GO:0006954,GO:0007159,GO:0007186,GO:0007267,GO:0008009,GO:0009615,GO:0009636,GO:0010536,GO:0010759,GO:0010820,GO:0014068,GO:0014911,GO:0016004,GO:0019221,GO:0030298,GO:0030335,GO:0030593,GO:0031328,GO:0031584,GO:0031663,GO:0031726,GO:0031729,GO:0031730,GO:0033634,GO:0034112,GO:0042056,GO:0042102,GO:0042119,GO:0042327,GO:0042379,GO:0042531,GO:0042802,GO:0042803,GO:0043491,GO:0043547,GO:0043621,GO:0043922,GO:0044344,GO:0045070,GO:0045071,GO:0045089,GO:0045744,GO:0045785,GO:0045948,GO:0046427,GO:0046817,GO:0048020,GO:0048245,GO:0048246,GO:0048247,GO:0048661,GO:0050796,GO:0050863,GO:0050918,GO:0051928,GO:0061098,GO:0070098,GO:0070100,GO:0070233,GO:0070234,GO:0070374,GO:0071346,GO:0071347,GO:0071356,GO:0071407,GO:0090026,GO:1901214,GO:2000406,GO:2000503" MAPK cascade|dendritic cell chemotaxis|monocyte chemotaxis|regulation of chronic inflammatory response|phosphatidylinositol phospholipase C activity|protein kinase activity|protein binding|extracellular region|extracellular space|protein phosphorylation|calcium ion transport|cellular calcium ion homeostasis|exocytosis|chemotaxis|inflammatory response|leukocyte cell-cell adhesion|G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|response to virus|response to toxic substance|positive regulation of activation of Janus kinase activity|positive regulation of macrophage chemotaxis|positive regulation of T cell chemotaxis|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of smooth muscle cell migration|phospholipase activator activity|cytokine-mediated signaling pathway|receptor signaling protein tyrosine kinase activator activity|positive regulation of cell migration|neutrophil chemotaxis|positive regulation of cellular biosynthetic process|activation of phospholipase D activity|lipopolysaccharide-mediated signaling pathway|CCR1 chemokine receptor binding|CCR4 chemokine receptor binding|CCR5 chemokine receptor binding|positive regulation of cell-cell adhesion mediated by integrin|positive regulation of homotypic cell-cell adhesion|chemoattractant activity|positive regulation of T cell proliferation|neutrophil activation|positive regulation of phosphorylation|chemokine receptor binding|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|protein homodimerization activity|protein kinase B signaling|positive regulation of GTPase activity|protein self-association|negative regulation by host of viral transcription|cellular response to fibroblast growth factor stimulus|positive regulation of viral genome replication|negative regulation of viral genome replication|positive regulation of innate immune response|negative regulation of G protein-coupled receptor signaling pathway|positive regulation of cell adhesion|positive regulation of translational initiation|positive regulation of receptor signaling pathway via JAK-STAT|chemokine receptor antagonist activity|CCR chemokine receptor binding|eosinophil chemotaxis|macrophage chemotaxis|lymphocyte chemotaxis|positive regulation of smooth muscle cell proliferation|regulation of insulin secretion|regulation of T cell activation|positive chemotaxis|positive regulation of calcium ion transport|positive regulation of protein tyrosine kinase activity|chemokine-mediated signaling pathway|negative regulation of chemokine-mediated signaling pathway|negative regulation of T cell apoptotic process|positive regulation of T cell apoptotic process|positive regulation of ERK1 and ERK2 cascade|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to organic cyclic compound|positive regulation of monocyte chemotaxis|regulation of neuron death|positive regulation of T cell migration|positive regulation of natural killer cell chemotaxis "hsa04060,hsa04061,hsa04062,hsa04620,hsa04621,hsa04623,hsa04668,hsa05020,hsa05120,hsa05131,hsa05142,hsa05163,hsa05164,hsa05168,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|TNF signaling pathway|Prion disease|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Chagas disease|Human cytomegalovirus infection|Influenza A|Herpes simplex virus 1 infection|Rheumatoid arthritis CCM2 1106.046406 948.9838304 1263.108982 1.331012122 0.412523711 0.233975466 1 15.01020712 20.83937192 83605 CCM2 scaffold protein "GO:0001570,GO:0001701,GO:0001885,GO:0005515,GO:0005737,GO:0005739,GO:0007229,GO:0032991,GO:0035264,GO:0045216,GO:0048839,GO:0048845,GO:0051403,GO:0060039,GO:0060837,GO:0061154" vasculogenesis|in utero embryonic development|endothelial cell development|protein binding|cytoplasm|mitochondrion|integrin-mediated signaling pathway|protein-containing complex|multicellular organism growth|cell-cell junction organization|inner ear development|venous blood vessel morphogenesis|stress-activated MAPK cascade|pericardium development|blood vessel endothelial cell differentiation|endothelial tube morphogenesis CCN1 3145.881741 2117.19815 4174.565333 1.971740497 0.97946969 0.002253626 0.152172743 47.07138598 96.81054659 3491 cellular communication network factor 1 "GO:0001649,GO:0001934,GO:0002041,GO:0003181,GO:0003278,GO:0003281,GO:0005178,GO:0005201,GO:0005515,GO:0005520,GO:0005788,GO:0006935,GO:0007155,GO:0007165,GO:0008201,GO:0010518,GO:0010811,GO:0030198,GO:0030335,GO:0030501,GO:0030513,GO:0031012,GO:0033690,GO:0043065,GO:0043066,GO:0043280,GO:0043687,GO:0044267,GO:0044319,GO:0045669,GO:0045860,GO:0045944,GO:0050840,GO:0060413,GO:0060548,GO:0060591,GO:0060710,GO:0060716,GO:0061036,GO:0062023,GO:0070372,GO:0072593,GO:2000304" "osteoblast differentiation|positive regulation of protein phosphorylation|intussusceptive angiogenesis|atrioventricular valve morphogenesis|apoptotic process involved in heart morphogenesis|ventricular septum development|integrin binding|extracellular matrix structural constituent|protein binding|insulin-like growth factor binding|endoplasmic reticulum lumen|chemotaxis|cell adhesion|signal transduction|heparin binding|positive regulation of phospholipase activity|positive regulation of cell-substrate adhesion|extracellular matrix organization|positive regulation of cell migration|positive regulation of bone mineralization|positive regulation of BMP signaling pathway|extracellular matrix|positive regulation of osteoblast proliferation|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|post-translational protein modification|cellular protein metabolic process|wound healing, spreading of cells|positive regulation of osteoblast differentiation|positive regulation of protein kinase activity|positive regulation of transcription by RNA polymerase II|extracellular matrix binding|atrial septum morphogenesis|negative regulation of cell death|chondroblast differentiation|chorio-allantoic fusion|labyrinthine layer blood vessel development|positive regulation of cartilage development|collagen-containing extracellular matrix|regulation of ERK1 and ERK2 cascade|reactive oxygen species metabolic process|positive regulation of ceramide biosynthetic process" CCN2 689.374322 517.6275439 861.1211001 1.663592114 0.734301751 0.053232508 1 11.21300642 19.45740209 1490 cellular communication network factor 2 "GO:0001502,GO:0001503,GO:0001525,GO:0001894,GO:0001934,GO:0001968,GO:0005178,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005801,GO:0005829,GO:0005886,GO:0005938,GO:0006367,GO:0007155,GO:0007160,GO:0007165,GO:0007229,GO:0007568,GO:0008022,GO:0008083,GO:0008201,GO:0008284,GO:0008543,GO:0008544,GO:0009611,GO:0009749,GO:0010628,GO:0010629,GO:0010942,GO:0016477,GO:0030154,GO:0030324,GO:0031012,GO:0032330,GO:0032355,GO:0032967,GO:0034059,GO:0035556,GO:0035988,GO:0043200,GO:0043280,GO:0043434,GO:0045597,GO:0046330,GO:0048471,GO:0050867,GO:0051385,GO:0051496,GO:0060401,GO:0060452,GO:0060548,GO:0062023,GO:0070278,GO:0070318,GO:0070374,GO:0070542,GO:0071897,GO:0072593" cartilage condensation|ossification|angiogenesis|tissue homeostasis|positive regulation of protein phosphorylation|fibronectin binding|integrin binding|protein binding|insulin-like growth factor binding|extracellular region|extracellular space|cis-Golgi network|cytosol|plasma membrane|cell cortex|transcription initiation from RNA polymerase II promoter|cell adhesion|cell-matrix adhesion|signal transduction|integrin-mediated signaling pathway|aging|protein C-terminus binding|growth factor activity|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|epidermis development|response to wounding|response to glucose|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell death|cell migration|cell differentiation|lung development|extracellular matrix|regulation of chondrocyte differentiation|response to estradiol|positive regulation of collagen biosynthetic process|response to anoxia|intracellular signal transduction|chondrocyte proliferation|response to amino acid|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to peptide hormone|positive regulation of cell differentiation|positive regulation of JNK cascade|perinuclear region of cytoplasm|positive regulation of cell activation|response to mineralocorticoid|positive regulation of stress fiber assembly|cytosolic calcium ion transport|positive regulation of cardiac muscle contraction|negative regulation of cell death|collagen-containing extracellular matrix|extracellular matrix constituent secretion|positive regulation of G0 to G1 transition|positive regulation of ERK1 and ERK2 cascade|response to fatty acid|DNA biosynthetic process|reactive oxygen species metabolic process "hsa04371,hsa04390" Apelin signaling pathway|Hippo signaling pathway CCN3 641.7238475 695.2448383 588.2028567 0.846036999 -0.241207338 0.532215264 1 14.29626406 12.61617914 4856 cellular communication network factor 3 "GO:0001525,GO:0002062,GO:0005112,GO:0005178,GO:0005515,GO:0005520,GO:0005576,GO:0005737,GO:0005921,GO:0007155,GO:0007165,GO:0008083,GO:0008201,GO:0010468,GO:0010761,GO:0010832,GO:0014909,GO:0030308,GO:0030424,GO:0030425,GO:0031012,GO:0033627,GO:0035767,GO:0043025,GO:0043231,GO:0044342,GO:0045747,GO:0046676,GO:0048659,GO:0050728,GO:0060326,GO:0060392,GO:0060548,GO:0061484,GO:0062023,GO:0071603,GO:0090027,GO:1901223,GO:1902731,GO:1904057,GO:1990523" angiogenesis|chondrocyte differentiation|Notch binding|integrin binding|protein binding|insulin-like growth factor binding|extracellular region|cytoplasm|gap junction|cell adhesion|signal transduction|growth factor activity|heparin binding|regulation of gene expression|fibroblast migration|negative regulation of myotube differentiation|smooth muscle cell migration|negative regulation of cell growth|axon|dendrite|extracellular matrix|cell adhesion mediated by integrin|endothelial cell chemotaxis|neuronal cell body|intracellular membrane-bounded organelle|type B pancreatic cell proliferation|positive regulation of Notch signaling pathway|negative regulation of insulin secretion|smooth muscle cell proliferation|negative regulation of inflammatory response|cell chemotaxis|negative regulation of SMAD protein signal transduction|negative regulation of cell death|hematopoietic stem cell homeostasis|collagen-containing extracellular matrix|endothelial cell-cell adhesion|negative regulation of monocyte chemotaxis|negative regulation of NIK/NF-kappaB signaling|negative regulation of chondrocyte proliferation|negative regulation of sensory perception of pain|bone regeneration CCNA1 355.0094268 358.2794568 351.7393967 0.981745925 -0.02657839 0.959585344 1 5.520410878 5.653097032 8900 cyclin A1 "GO:0000079,GO:0000083,GO:0000307,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007141,GO:0007283,GO:0015630,GO:0016538,GO:0016579,GO:0044772,GO:0051301,GO:0097123,GO:0097124" regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of transcription involved in G1/S transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|male meiosis I|spermatogenesis|microtubule cytoskeleton|cyclin-dependent protein serine/threonine kinase regulator activity|protein deubiquitination|mitotic cell cycle phase transition|cell division|cyclin A1-CDK2 complex|cyclin A2-CDK2 complex "hsa04110,hsa04152,hsa04218,hsa04914,hsa05161,hsa05165,hsa05166,hsa05169,hsa05200,hsa05202,hsa05203,hsa05221" Cell cycle|AMPK signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Hepatitis B|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Acute myeloid leukemia CCNA2 1527.119767 1411.803752 1642.435782 1.163359837 0.218297403 0.509782612 1 26.0199707 31.57452307 890 cyclin A2 "GO:0000079,GO:0000086,GO:0000307,GO:0001939,GO:0001940,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006275,GO:0007265,GO:0016032,GO:0016538,GO:0016572,GO:0016579,GO:0019901,GO:0019904,GO:0031100,GO:0033762,GO:0036120,GO:0044320,GO:0044772,GO:0044843,GO:0045893,GO:0048146,GO:0051301,GO:0071314,GO:0071373,GO:0071392,GO:0071456,GO:0071732,GO:0090102,GO:0097124,GO:1990314" "regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|female pronucleus|male pronucleus|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA replication|Ras protein signal transduction|viral process|cyclin-dependent protein serine/threonine kinase regulator activity|histone phosphorylation|protein deubiquitination|protein kinase binding|protein domain specific binding|animal organ regeneration|response to glucagon|cellular response to platelet-derived growth factor stimulus|cellular response to leptin stimulus|mitotic cell cycle phase transition|cell cycle G1/S phase transition|positive regulation of transcription, DNA-templated|positive regulation of fibroblast proliferation|cell division|cellular response to cocaine|cellular response to luteinizing hormone stimulus|cellular response to estradiol stimulus|cellular response to hypoxia|cellular response to nitric oxide|cochlea development|cyclin A2-CDK2 complex|cellular response to insulin-like growth factor stimulus" "hsa04110,hsa04152,hsa04218,hsa04914,hsa05161,hsa05165,hsa05166,hsa05169,hsa05200,hsa05202,hsa05203,hsa05221" Cell cycle|AMPK signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Hepatitis B|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Acute myeloid leukemia CCNB1 4379.849718 4334.876941 4424.822495 1.020749275 0.029628543 0.926802439 1 108.2041521 115.2070181 891 cyclin B1 "GO:0000079,GO:0000086,GO:0000307,GO:0000922,GO:0000942,GO:0001556,GO:0001701,GO:0001933,GO:0005113,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005813,GO:0005829,GO:0006367,GO:0006977,GO:0007052,GO:0007077,GO:0007080,GO:0007283,GO:0009612,GO:0010629,GO:0010971,GO:0016020,GO:0016538,GO:0019901,GO:0031145,GO:0031442,GO:0033129,GO:0042246,GO:0042493,GO:0044389,GO:0044772,GO:0045737,GO:0045931,GO:0046680,GO:0048146,GO:0048565,GO:0051301,GO:0051726,GO:0051987,GO:0055015,GO:0060045,GO:0060623,GO:0061575,GO:0065003,GO:0071283,GO:0071398,GO:0071407,GO:0071456,GO:0090266,GO:0097125,GO:1901990,GO:1905448,GO:2000775" "regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|spindle pole|condensed nuclear chromosome outer kinetochore|oocyte maturation|in utero embryonic development|negative regulation of protein phosphorylation|patched binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|centrosome|cytosol|transcription initiation from RNA polymerase II promoter|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|mitotic spindle organization|mitotic nuclear envelope disassembly|mitotic metaphase plate congression|spermatogenesis|response to mechanical stimulus|negative regulation of gene expression|positive regulation of G2/M transition of mitotic cell cycle|membrane|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|anaphase-promoting complex-dependent catabolic process|positive regulation of mRNA 3'-end processing|positive regulation of histone phosphorylation|tissue regeneration|response to drug|ubiquitin-like protein ligase binding|mitotic cell cycle phase transition|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of mitotic cell cycle|response to DDT|positive regulation of fibroblast proliferation|digestive tract development|cell division|regulation of cell cycle|positive regulation of attachment of spindle microtubules to kinetochore|ventricular cardiac muscle cell development|positive regulation of cardiac muscle cell proliferation|regulation of chromosome condensation|cyclin-dependent protein serine/threonine kinase activator activity|protein-containing complex assembly|cellular response to iron(III) ion|cellular response to fatty acid|cellular response to organic cyclic compound|cellular response to hypoxia|regulation of mitotic cell cycle spindle assembly checkpoint|cyclin B1-CDK1 complex|regulation of mitotic cell cycle phase transition|positive regulation of mitochondrial ATP synthesis coupled electron transport|histone H3-S10 phosphorylation involved in chromosome condensation" "hsa04068,hsa04110,hsa04114,hsa04115,hsa04218,hsa04914,hsa05170" FoxO signaling pathway|Cell cycle|Oocyte meiosis|p53 signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection CCNB1IP1 908.8680757 839.3685858 978.3675656 1.165599454 0.221072107 0.538358276 1 25.74867217 31.30546097 57820 cyclin B1 interacting protein 1 "GO:0000795,GO:0005515,GO:0007131,GO:0016567,GO:0042802,GO:0046872,GO:0051026,GO:0061630" synaptonemal complex|protein binding|reciprocal meiotic recombination|protein ubiquitination|identical protein binding|metal ion binding|chiasma assembly|ubiquitin protein ligase activity CCNB2 1447.02732 1257.530445 1636.524196 1.301379384 0.380041605 0.253972397 1 42.80207038 58.10113671 9133 cyclin B2 "GO:0000079,GO:0000086,GO:0000307,GO:0001701,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0007057,GO:0007077,GO:0008315,GO:0015630,GO:0016020,GO:0016538,GO:0040008,GO:0043029,GO:0044772,GO:0045296,GO:0048538,GO:0051301,GO:0051726" regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|in utero embryonic development|protein binding|nucleus|cytoplasm|centrosome|cytosol|spindle assembly involved in female meiosis I|mitotic nuclear envelope disassembly|G2/MI transition of meiotic cell cycle|microtubule cytoskeleton|membrane|cyclin-dependent protein serine/threonine kinase regulator activity|regulation of growth|T cell homeostasis|mitotic cell cycle phase transition|cadherin binding|thymus development|cell division|regulation of cell cycle "hsa04068,hsa04110,hsa04114,hsa04115,hsa04218,hsa04914,hsa05166,hsa05170" FoxO signaling pathway|Cell cycle|Oocyte meiosis|p53 signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection CCNB3 11.11997832 19.2841634 2.95579325 0.15327568 -2.705799294 0.063130547 1 0.197547501 0.031583534 85417 cyclin B3 "GO:0000079,GO:0000307,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0010389,GO:0016538,GO:0016607,GO:0019901,GO:0044772,GO:0051301,GO:0051321" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|cytoplasm|centrosome|regulation of G2/M transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase regulator activity|nuclear speck|protein kinase binding|mitotic cell cycle phase transition|cell division|meiotic cell cycle "hsa04068,hsa04110,hsa04218,hsa04914,hsa05170" FoxO signaling pathway|Cell cycle|Cellular senescence|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection CCNC 717.8955257 783.5460076 652.2450438 0.832427244 -0.264603912 0.482056794 1 14.77982909 12.83310144 892 cyclin C "GO:0000079,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0016538,GO:0016592,GO:0042802,GO:0045944" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|cyclin-dependent protein serine/threonine kinase regulator activity|mediator complex|identical protein binding|positive regulation of transcription by RNA polymerase II CCND1 11647.34318 11083.31917 12211.36718 1.101778897 0.139834736 0.681941258 1 132.451868 152.2188608 595 cyclin D1 "GO:0000079,GO:0000082,GO:0000122,GO:0000307,GO:0000320,GO:0001934,GO:0003714,GO:0004672,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005923,GO:0006367,GO:0006468,GO:0006974,GO:0007595,GO:0008134,GO:0010039,GO:0010165,GO:0010243,GO:0010971,GO:0016055,GO:0016538,GO:0017053,GO:0019221,GO:0019899,GO:0019901,GO:0030857,GO:0030968,GO:0031571,GO:0031965,GO:0032026,GO:0032355,GO:0033197,GO:0033327,GO:0033598,GO:0033601,GO:0042493,GO:0042826,GO:0043627,GO:0044321,GO:0044772,GO:0044877,GO:0045444,GO:0045471,GO:0045737,GO:0045787,GO:0051301,GO:0051412,GO:0051592,GO:0060749,GO:0070064,GO:0070141,GO:0071157,GO:0097421,GO:1900087" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|cyclin-dependent protein kinase holoenzyme complex|re-entry into mitotic cell cycle|positive regulation of protein phosphorylation|transcription corepressor activity|protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|bicellular tight junction|transcription initiation from RNA polymerase II promoter|protein phosphorylation|cellular response to DNA damage stimulus|lactation|transcription factor binding|response to iron ion|response to X-ray|response to organonitrogen compound|positive regulation of G2/M transition of mitotic cell cycle|Wnt signaling pathway|cyclin-dependent protein serine/threonine kinase regulator activity|transcription repressor complex|cytokine-mediated signaling pathway|enzyme binding|protein kinase binding|negative regulation of epithelial cell differentiation|endoplasmic reticulum unfolded protein response|mitotic G1 DNA damage checkpoint|nuclear membrane|response to magnesium ion|response to estradiol|response to vitamin E|Leydig cell differentiation|mammary gland epithelial cell proliferation|positive regulation of mammary gland epithelial cell proliferation|response to drug|histone deacetylase binding|response to estrogen|response to leptin|mitotic cell cycle phase transition|protein-containing complex binding|fat cell differentiation|response to ethanol|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of cell cycle|cell division|response to corticosterone|response to calcium ion|mammary gland alveolus development|proline-rich region binding|response to UV-A|negative regulation of cell cycle arrest|liver regeneration|positive regulation of G1/S transition of mitotic cell cycle "hsa01522,hsa04068,hsa04110,hsa04115,hsa04151,hsa04152,hsa04218,hsa04310,hsa04340,hsa04371,hsa04390,hsa04510,hsa04530,hsa04630,hsa04917,hsa04919,hsa04921,hsa04933,hsa04934,hsa05160,hsa05162,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05416" Endocrine resistance|FoxO signaling pathway|Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Cellular senescence|Wnt signaling pathway|Hedgehog signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Focal adhesion|Tight junction|JAK-STAT signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Hepatitis C|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Viral myocarditis CCND3 1064.754375 955.0735662 1174.435185 1.229680337 0.298283326 0.392590758 1 16.59386169 21.28411634 896 cyclin D3 "GO:0000079,GO:0000122,GO:0000307,GO:0001934,GO:0004693,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007165,GO:0016020,GO:0016538,GO:0019901,GO:0042098,GO:0042127,GO:0044772,GO:0045737,GO:0046626,GO:0051301,GO:1900087" regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription by RNA polymerase II|cyclin-dependent protein kinase holoenzyme complex|positive regulation of protein phosphorylation|cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|signal transduction|membrane|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|T cell proliferation|regulation of cell population proliferation|mitotic cell cycle phase transition|positive regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of insulin receptor signaling pathway|cell division|positive regulation of G1/S transition of mitotic cell cycle "hsa04110,hsa04115,hsa04151,hsa04218,hsa04310,hsa04390,hsa04510,hsa04630,hsa05162,hsa05164,hsa05165,hsa05166,hsa05169,hsa05200,hsa05203" Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Wnt signaling pathway|Hippo signaling pathway|Focal adhesion|JAK-STAT signaling pathway|Measles|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis CCNDBP1 817.9971034 689.1551025 946.8391043 1.373912927 0.458290575 0.210381923 1 9.402821861 13.47514192 23582 cyclin D1 binding protein 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007049,GO:0016604,GO:0051726" protein binding|nucleus|nucleoplasm|cytoplasm|cell cycle|nuclear body|regulation of cell cycle CCNE1 345.8748231 340.0102494 351.7393967 1.034496452 0.048928697 0.920380724 1 8.812855501 9.509585437 898 cyclin E1 "GO:0000079,GO:0000082,GO:0000083,GO:0000122,GO:0000307,GO:0000723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006270,GO:0006468,GO:0007129,GO:0016055,GO:0016301,GO:0016538,GO:0019901,GO:0044772,GO:0051301,GO:0097134,GO:1902462,GO:1903827" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|cyclin-dependent protein kinase holoenzyme complex|telomere maintenance|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA replication initiation|protein phosphorylation|homologous chromosome pairing at meiosis|Wnt signaling pathway|kinase activity|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|mitotic cell cycle phase transition|cell division|cyclin E1-CDK2 complex|positive regulation of mesenchymal stem cell proliferation|regulation of cellular protein localization "hsa04110,hsa04114,hsa04115,hsa04151,hsa04218,hsa04934,hsa05161,hsa05162,hsa05165,hsa05166,hsa05169,hsa05200,hsa05203,hsa05206,hsa05215,hsa05222,hsa05226" Cell cycle|Oocyte meiosis|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Cushing syndrome|Hepatitis B|Measles|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Prostate cancer|Small cell lung cancer|Gastric cancer CCNE2 719.8554142 547.061267 892.6495614 1.631717717 0.706391496 0.060456967 1 7.249273484 12.33830333 9134 cyclin E2 "GO:0000079,GO:0000082,GO:0000307,GO:0000723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006270,GO:0007129,GO:0016538,GO:0019901,GO:0044772,GO:0051301,GO:0097134,GO:0097135,GO:1903827" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|telomere maintenance|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA replication initiation|homologous chromosome pairing at meiosis|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|mitotic cell cycle phase transition|cell division|cyclin E1-CDK2 complex|cyclin E2-CDK2 complex|regulation of cellular protein localization "hsa04110,hsa04114,hsa04115,hsa04151,hsa04218,hsa04934,hsa05161,hsa05162,hsa05165,hsa05166,hsa05169,hsa05200,hsa05203,hsa05206,hsa05215,hsa05222,hsa05226" Cell cycle|Oocyte meiosis|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Cushing syndrome|Hepatitis B|Measles|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Prostate cancer|Small cell lung cancer|Gastric cancer CCNF 1208.903855 1110.361829 1307.445881 1.177495341 0.235721351 0.49078034 1 13.29454126 16.32858244 899 cyclin F "GO:0000079,GO:0000209,GO:0000307,GO:0000320,GO:0001890,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0010826,GO:0016538,GO:0016567,GO:0019005,GO:0030054,GO:0031146,GO:0043687,GO:0044772,GO:0051301" regulation of cyclin-dependent protein serine/threonine kinase activity|protein polyubiquitination|cyclin-dependent protein kinase holoenzyme complex|re-entry into mitotic cell cycle|placenta development|protein binding|nucleus|cytoplasm|centrosome|centriole|cytosol|negative regulation of centrosome duplication|cyclin-dependent protein serine/threonine kinase regulator activity|protein ubiquitination|SCF ubiquitin ligase complex|cell junction|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|mitotic cell cycle phase transition|cell division CCNG1 3329.669682 2591.182587 4068.156776 1.570000044 0.6507646 0.041346396 0.934015076 55.419872 90.757205 900 cyclin G1 "GO:0000079,GO:0000307,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016538,GO:0044772,GO:0051301" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|nucleoplasm|cytoplasm|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition|cell division "hsa04115,hsa05206" p53 signaling pathway|MicroRNAs in cancer CCNG2 834.3267113 896.2061201 772.4473026 0.861908087 -0.214394065 0.557324112 1 14.68446404 13.20185582 901 cyclin G2 "GO:0000079,GO:0000307,GO:0005634,GO:0005737,GO:0016538,GO:0044772,GO:0051301" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition|cell division "hsa04068,hsa04115" FoxO signaling pathway|p53 signaling pathway CCNH 941.5369402 951.0137424 932.0601381 0.980070105 -0.029043146 0.938099757 1 7.157897321 7.317429316 902 cyclin H "GO:0000079,GO:0000082,GO:0000086,GO:0000439,GO:0005515,GO:0005634,GO:0005654,GO:0005675,GO:0006283,GO:0006294,GO:0006357,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0016251,GO:0016538,GO:0019907,GO:0050821,GO:0070516,GO:0070816,GO:0070985" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|transcription factor TFIIH core complex|protein binding|nucleus|nucleoplasm|transcription factor TFIIH holo complex|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|RNA polymerase II general transcription initiation factor activity|cyclin-dependent protein serine/threonine kinase regulator activity|cyclin-dependent protein kinase activating kinase holoenzyme complex|protein stabilization|CAK-ERCC2 complex|phosphorylation of RNA polymerase II C-terminal domain|transcription factor TFIIK complex" "hsa03022,hsa03420,hsa04110" Basal transcription factors|Nucleotide excision repair|Cell cycle CCNI 4768.435577 3923.819774 5613.051381 1.430506931 0.516526487 0.107575586 1 69.002649 102.960741 10983 cyclin I "GO:0000079,GO:0000307,GO:0005515,GO:0005634,GO:0005737,GO:0007283,GO:0016538,GO:0031965,GO:0044772" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|cytoplasm|spermatogenesis|cyclin-dependent protein serine/threonine kinase regulator activity|nuclear membrane|mitotic cell cycle phase transition CCNI2 5.508028946 6.08973581 4.926322083 0.808954975 -0.305868687 0.976518791 1 0.127132579 0.107274657 645121 cyclin I family member 2 "GO:0000079,GO:0000307,GO:0005634,GO:0005737,GO:0016538,GO:0044772" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition CCNJ 611.2036612 595.7791534 626.6281689 1.05177928 0.072831981 0.855330349 1 7.165545557 7.861217316 54619 cyclin J "GO:0000079,GO:0000307,GO:0005634,GO:0005737,GO:0005813,GO:0016538,GO:0044772" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm|centrosome|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition CCNJL 564.7626216 586.6445497 542.8806935 0.925399705 -0.111851455 0.781258141 1 3.788762673 3.657149286 79616 cyclin J like "GO:0000079,GO:0000307,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0016538,GO:0044772" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|cytoplasm|centrosome|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition CCNK 1205.636301 1089.047754 1322.224847 1.21411099 0.279900314 0.41317461 1 19.01290135 24.07812778 8812 cyclin K "GO:0000079,GO:0002944,GO:0002945,GO:0004693,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0006368,GO:0006468,GO:0006974,GO:0007049,GO:0008024,GO:0008353,GO:0016538,GO:0019901,GO:0032786,GO:0042795,GO:0044828,GO:0045737,GO:0045944,GO:0051301,GO:0061575,GO:2001165" "regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin K-CDK12 complex|cyclin K-CDK13 complex|cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|protein phosphorylation|cellular response to DNA damage stimulus|cell cycle|cyclin/CDK positive transcription elongation factor complex|RNA polymerase II CTD heptapeptide repeat kinase activity|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|positive regulation of DNA-templated transcription, elongation|snRNA transcription by RNA polymerase II|negative regulation by host of viral genome replication|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|cell division|cyclin-dependent protein serine/threonine kinase activator activity|positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues" CCNL1 943.0554148 819.0694665 1067.041363 1.30274831 0.381558383 0.284060754 1 6.431469608 8.739501674 57018 cyclin L1 "GO:0000079,GO:0005515,GO:0005634,GO:0006357,GO:0006396,GO:0016538,GO:0016607" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|RNA processing|cyclin-dependent protein serine/threonine kinase regulator activity|nuclear speck CCNL2 2607.615363 2466.343003 2748.887722 1.114560188 0.156474527 0.623954784 1 24.73496483 28.75615084 81669 cyclin L2 "GO:0000079,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0016538,GO:0016607,GO:0043231" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cyclin-dependent protein serine/threonine kinase regulator activity|nuclear speck|intracellular membrane-bounded organelle CCNO 230.8203352 186.7518982 274.8887722 1.471946336 0.557725075 0.278968783 1 6.949540648 10.66998984 10309 cyclin O "GO:0000079,GO:0000278,GO:0000307,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0016538,GO:0042493,GO:0044772,GO:0051301,GO:0060271,GO:0097124,GO:1903251" regulation of cyclin-dependent protein serine/threonine kinase activity|mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|nucleolus|cytoplasm|cyclin-dependent protein serine/threonine kinase regulator activity|response to drug|mitotic cell cycle phase transition|cell division|cilium assembly|cyclin A2-CDK2 complex|multi-ciliated epithelial cell differentiation CCNQ 513.8042607 504.4331163 523.1754052 1.037155152 0.052631728 0.901501556 1 9.829841403 10.63423295 92002 cyclin Q "GO:0000079,GO:0005515,GO:0005634,GO:0006357,GO:0016538" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|cyclin-dependent protein serine/threonine kinase regulator activity CCNT1 1254.206967 1344.816658 1163.597276 0.865246031 -0.208817676 0.53948642 1 9.922817527 8.955514691 904 cyclin T1 "GO:0000079,GO:0000976,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0006366,GO:0006368,GO:0006468,GO:0007049,GO:0008024,GO:0008134,GO:0016032,GO:0016538,GO:0019901,GO:0032786,GO:0042795,GO:0043923,GO:0045737,GO:0045944,GO:0050434,GO:0051301,GO:0061575,GO:0070063,GO:0070691,GO:0097322,GO:1900364" "regulation of cyclin-dependent protein serine/threonine kinase activity|transcription regulatory region sequence-specific DNA binding|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|protein phosphorylation|cell cycle|cyclin/CDK positive transcription elongation factor complex|transcription factor binding|viral process|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|positive regulation of DNA-templated transcription, elongation|snRNA transcription by RNA polymerase II|positive regulation by host of viral transcription|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|positive regulation of viral transcription|cell division|cyclin-dependent protein serine/threonine kinase activator activity|RNA polymerase binding|P-TEFb complex|7SK snRNA binding|negative regulation of mRNA polyadenylation" hsa05202 Transcriptional misregulation in cancer CCNT2 630.211198 548.0762229 712.3461732 1.299720994 0.378201959 0.328256056 1 3.280714714 4.447690209 905 cyclin T2 "GO:0000079,GO:0001223,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0006366,GO:0006368,GO:0007049,GO:0007519,GO:0008024,GO:0016538,GO:0019085,GO:0019086,GO:0032786,GO:0042795,GO:0045737,GO:0045944,GO:0048471,GO:0051301,GO:0061575,GO:0070063,GO:0097322" "regulation of cyclin-dependent protein serine/threonine kinase activity|transcription coactivator binding|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|cell cycle|skeletal muscle tissue development|cyclin/CDK positive transcription elongation factor complex|cyclin-dependent protein serine/threonine kinase regulator activity|early viral transcription|late viral transcription|positive regulation of DNA-templated transcription, elongation|snRNA transcription by RNA polymerase II|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|cell division|cyclin-dependent protein serine/threonine kinase activator activity|RNA polymerase binding|7SK snRNA binding" hsa05202 Transcriptional misregulation in cancer other CCNY 1204.915538 1140.810508 1269.020569 1.112385062 0.153656277 0.654239856 1 10.61120803 12.31220695 219771 cyclin Y "GO:0000086,GO:0000308,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0016055,GO:0016538,GO:0019901,GO:0045737,GO:0051301,GO:0060828" G2/M transition of mitotic cell cycle|cytoplasmic cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|cytoplasm|plasma membrane|Wnt signaling pathway|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|regulation of canonical Wnt signaling pathway CCNYL1 695.7594895 752.0823726 639.4366063 0.850221505 -0.234089346 0.537118082 1 10.69652316 9.486164489 151195 cyclin Y like 1 "GO:0005515,GO:0005737,GO:0005886,GO:0007283,GO:0016538,GO:0019901,GO:0030317,GO:0045737" protein binding|cytoplasm|plasma membrane|spermatogenesis|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|flagellated sperm motility|positive regulation of cyclin-dependent protein serine/threonine kinase activity CCP110 555.7428247 441.5058462 669.9798033 1.517487954 0.601685064 0.131053387 1 4.430496052 7.012833628 9738 centriolar coiled-coil protein 110 "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0007099,GO:0010389,GO:0016579,GO:0032053,GO:0032465,GO:0032991,GO:0045724,GO:0051298,GO:0097711,GO:1902018,GO:1903723" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|cytosol|cilium|centriole replication|regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|ciliary basal body organization|regulation of cytokinesis|protein-containing complex|positive regulation of cilium assembly|centrosome duplication|ciliary basal body-plasma membrane docking|negative regulation of cilium assembly|negative regulation of centriole elongation CCPG1 974.2585068 965.2231259 983.2938877 1.018721849 0.026760193 0.94277479 1 6.928166982 7.361899714 9236 cell cycle progression 1 "GO:0003674,GO:0005515,GO:0007049,GO:0008284,GO:0016020,GO:0016021,GO:0045787,GO:0045944,GO:2001106" molecular_function|protein binding|cell cycle|positive regulation of cell population proliferation|membrane|integral component of membrane|positive regulation of cell cycle|positive regulation of transcription by RNA polymerase II|regulation of Rho guanyl-nucleotide exchange factor activity CCR10 37.67485864 49.73284245 25.61687483 0.515089699 -0.957104407 0.303085868 1 1.420639043 0.76327764 2826 C-C motif chemokine receptor 10 "GO:0004930,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0006955,GO:0007186,GO:0007204,GO:0009897,GO:0009986,GO:0016493,GO:0019722,GO:0019957,GO:0060326,GO:0070098" G protein-coupled receptor activity|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|immune response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|external side of plasma membrane|cell surface|C-C chemokine receptor activity|calcium-mediated signaling|C-C chemokine binding|cell chemotaxis|chemokine-mediated signaling pathway "hsa04060,hsa04061,hsa04062,hsa04672" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|Intestinal immune network for IgA production CCRL2 13.06081561 17.25425146 8.867379749 0.513924337 -0.960372121 0.468354988 1 0.468059436 0.250908931 9034 C-C motif chemokine receptor like 2 "GO:0004950,GO:0005737,GO:0005886,GO:0005887,GO:0006935,GO:0006954,GO:0006955,GO:0007186,GO:0007204,GO:0009897,GO:0016493,GO:0019722,GO:0019957,GO:0042379,GO:0048020,GO:0060326,GO:0070098" chemokine receptor activity|cytoplasm|plasma membrane|integral component of plasma membrane|chemotaxis|inflammatory response|immune response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|external side of plasma membrane|C-C chemokine receptor activity|calcium-mediated signaling|C-C chemokine binding|chemokine receptor binding|CCR chemokine receptor binding|cell chemotaxis|chemokine-mediated signaling pathway CCS 380.5493511 386.698224 374.4004783 0.968198081 -0.04662586 0.921651392 1 18.37232725 18.55428913 9973 copper chaperone for superoxide dismutase "GO:0004784,GO:0005507,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006801,GO:0015035,GO:0015680,GO:0019430,GO:0030001,GO:0034599,GO:0045296,GO:0051353,GO:0055114" superoxide dismutase activity|copper ion binding|protein binding|nucleus|cytoplasm|cytosol|superoxide metabolic process|protein disulfide oxidoreductase activity|protein maturation by copper ion transfer|removal of superoxide radicals|metal ion transport|cellular response to oxidative stress|cadherin binding|positive regulation of oxidoreductase activity|oxidation-reduction process "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases CCSAP 808.2253691 795.7254792 820.725259 1.031417594 0.04462856 0.906422733 1 5.86362409 6.308361686 126731 "centriole, cilia and spindle associated protein" "GO:0005813,GO:0005814,GO:0005819,GO:0005929,GO:0005930,GO:0007049,GO:0007275,GO:0008017,GO:0030424,GO:0035869,GO:0036064,GO:0045995,GO:0051301,GO:0060296,GO:0061673,GO:0072686,GO:1901673,GO:1990755" centrosome|centriole|spindle|cilium|axoneme|cell cycle|multicellular organism development|microtubule binding|axon|ciliary transition zone|ciliary basal body|regulation of embryonic development|cell division|regulation of cilium beat frequency involved in ciliary motility|mitotic spindle astral microtubule|mitotic spindle|regulation of mitotic spindle assembly|mitotic spindle microtubule depolymerization CCSER1 5.015396738 6.08973581 3.941057666 0.64716398 -0.627796782 0.826813936 1 0.008479467 0.005723989 401145 coiled-coil serine rich protein 1 CCSER2 1057.706345 978.4175535 1136.995137 1.162075571 0.216703891 0.535494079 1 4.979240096 6.035501599 54462 coiled-coil serine rich protein 2 "GO:0001578,GO:0005737,GO:0008017,GO:0015630" microtubule bundle formation|cytoplasm|microtubule binding|microtubule cytoskeleton CCT2 4492.411107 4856.564309 4128.257905 0.850036701 -0.234402962 0.463587718 1 120.7500487 107.0633731 10576 chaperonin containing TCP1 subunit 2 "GO:0002199,GO:0005515,GO:0005524,GO:0005576,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007339,GO:0031625,GO:0032212,GO:0035578,GO:0043312,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0051086,GO:0051131,GO:0051973,GO:0070062,GO:0090666,GO:1901998,GO:1904851,GO:1904871,GO:1904874" zona pellucida receptor complex|protein binding|ATP binding|extracellular region|cytosol|chaperonin-containing T-complex|microtubule|protein folding|binding of sperm to zona pellucida|ubiquitin protein ligase binding|positive regulation of telomere maintenance via telomerase|azurophil granule lumen|neutrophil degranulation|protein folding chaperone|cell body|protein stabilization|unfolded protein binding|chaperone mediated protein folding independent of cofactor|chaperone-mediated protein complex assembly|positive regulation of telomerase activity|extracellular exosome|scaRNA localization to Cajal body|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT3 7580.331494 8197.799357 6962.863632 0.849357654 -0.235555912 0.474512138 1 210.0099228 186.0571439 7203 chaperonin containing TCP1 subunit 3 "GO:0002199,GO:0003723,GO:0005515,GO:0005524,GO:0005829,GO:0005832,GO:0005856,GO:0005874,GO:0006457,GO:0007339,GO:0032212,GO:0044183,GO:0044297,GO:0046931,GO:0050821,GO:0051082,GO:0070062,GO:1901998,GO:1904851,GO:1904871,GO:1904874" zona pellucida receptor complex|RNA binding|protein binding|ATP binding|cytosol|chaperonin-containing T-complex|cytoskeleton|microtubule|protein folding|binding of sperm to zona pellucida|positive regulation of telomere maintenance via telomerase|protein folding chaperone|cell body|pore complex assembly|protein stabilization|unfolded protein binding|extracellular exosome|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT4 4436.872082 4562.227078 4311.517087 0.945046578 -0.081542659 0.799077596 1 96.63768587 95.26111601 10575 chaperonin containing TCP1 subunit 4 "GO:0002199,GO:0003723,GO:0005515,GO:0005524,GO:0005654,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007339,GO:0032212,GO:0042470,GO:0042995,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0051973,GO:0070062,GO:0090666,GO:1901998,GO:1904851,GO:1904871,GO:1904874" zona pellucida receptor complex|RNA binding|protein binding|ATP binding|nucleoplasm|centrosome|cytosol|chaperonin-containing T-complex|microtubule|protein folding|binding of sperm to zona pellucida|positive regulation of telomere maintenance via telomerase|melanosome|cell projection|protein folding chaperone|cell body|protein stabilization|unfolded protein binding|positive regulation of telomerase activity|extracellular exosome|scaRNA localization to Cajal body|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT5 9369.216867 9992.241509 8746.192226 0.875298322 -0.19215329 0.565875007 1 134.0587502 122.3959907 22948 chaperonin containing TCP1 subunit 5 "GO:0003730,GO:0005515,GO:0005524,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007339,GO:0009615,GO:0031681,GO:0032212,GO:0044183,GO:0044297,GO:0048027,GO:0048487,GO:0050821,GO:0051082,GO:0070062,GO:1901998,GO:1904851,GO:1904871,GO:1904874" mRNA 3'-UTR binding|protein binding|ATP binding|centrosome|cytosol|chaperonin-containing T-complex|microtubule|protein folding|binding of sperm to zona pellucida|response to virus|G-protein beta-subunit binding|positive regulation of telomere maintenance via telomerase|protein folding chaperone|cell body|mRNA 5'-UTR binding|beta-tubulin binding|protein stabilization|unfolded protein binding|extracellular exosome|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT6A 7060.484757 7650.73809 6470.231423 0.84570029 -0.241781621 0.460741295 1 149.9546804 132.2794665 908 chaperonin containing TCP1 subunit 6A "GO:0003723,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0032212,GO:0044183,GO:0050821,GO:0051082,GO:0070062,GO:0071987,GO:1904851,GO:1904871,GO:1904874" RNA binding|protein binding|ATP binding|cytoplasm|cytosol|chaperonin-containing T-complex|microtubule|protein folding|positive regulation of telomere maintenance via telomerase|protein folding chaperone|protein stabilization|unfolded protein binding|extracellular exosome|WD40-repeat domain binding|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT6B 15.03134444 17.25425146 12.80843742 0.742335154 -0.429857404 0.763684095 1 0.402518179 0.311674633 10693 chaperonin containing TCP1 subunit 6B "GO:0005524,GO:0005829,GO:0005832,GO:0006457,GO:0044183,GO:0051082,GO:1901998" ATP binding|cytosol|chaperonin-containing T-complex|protein folding|protein folding chaperone|unfolded protein binding|toxin transport CCT7 5344.447092 5515.270732 5173.623451 0.938054305 -0.092256651 0.774939278 1 137.4650619 134.5043229 10574 chaperonin containing TCP1 subunit 7 "GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007339,GO:0032212,GO:0042802,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0070062,GO:1901998,GO:1904851,GO:1904871,GO:1904874" protein binding|ATP binding|cytoplasm|cytosol|chaperonin-containing T-complex|microtubule|protein folding|binding of sperm to zona pellucida|positive regulation of telomere maintenance via telomerase|identical protein binding|protein folding chaperone|cell body|protein stabilization|unfolded protein binding|extracellular exosome|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT8 3736.114764 3771.576378 3700.653149 0.981195335 -0.02738772 0.932275144 1 88.35200659 90.42485517 10694 chaperonin containing TCP1 subunit 8 "GO:0002199,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0005929,GO:0006457,GO:0007339,GO:0016887,GO:0032212,GO:0034774,GO:0035578,GO:0043312,GO:0044183,GO:0044297,GO:0045111,GO:0045296,GO:0046931,GO:0050821,GO:0051082,GO:0070062,GO:1901998,GO:1904813,GO:1904851,GO:1904871,GO:1904874" zona pellucida receptor complex|protein binding|ATP binding|extracellular region|nucleoplasm|cytoplasm|centrosome|cytosol|chaperonin-containing T-complex|microtubule|cilium|protein folding|binding of sperm to zona pellucida|ATPase activity|positive regulation of telomere maintenance via telomerase|secretory granule lumen|azurophil granule lumen|neutrophil degranulation|protein folding chaperone|cell body|intermediate filament cytoskeleton|cadherin binding|pore complex assembly|protein stabilization|unfolded protein binding|extracellular exosome|toxin transport|ficolin-1-rich granule lumen|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCZ1 169.1846477 149.1985274 189.170768 1.267913104 0.342455875 0.551334072 1 3.176283762 4.20072948 51622 "CCZ1 homolog, vacuolar protein trafficking and biogenesis associated" "GO:0005085,GO:0005515,GO:0005765,GO:0005829,GO:0016192,GO:0035658,GO:0043231,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|lysosomal membrane|cytosol|vesicle-mediated transport|Mon1-Ccz1 complex|intracellular membrane-bounded organelle|regulation of catalytic activity CCZ1B 657.1290579 704.3794421 609.8786738 0.865838265 -0.207830535 0.588912849 1 19.66611568 17.76115867 221960 "CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated" "GO:0005765,GO:0016192,GO:0035658,GO:0043231" lysosomal membrane|vesicle-mediated transport|Mon1-Ccz1 complex|intracellular membrane-bounded organelle CD101 6.493293363 6.08973581 6.896850916 1.132536966 0.17955814 1 1 0.050322016 0.059446508 9398 CD101 molecule "GO:0002763,GO:0005886,GO:0007166,GO:0016021,GO:0016812,GO:0070062" "positive regulation of myeloid leukocyte differentiation|plasma membrane|cell surface receptor signaling pathway|integral component of membrane|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides|extracellular exosome" CD109 1833.011709 1813.726315 1852.297103 1.021266046 0.030358746 0.927150208 1 10.17150254 10.83527492 135228 CD109 molecule "GO:0001933,GO:0001942,GO:0002576,GO:0004867,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0009986,GO:0010839,GO:0010951,GO:0030512,GO:0031092,GO:0031225,GO:0045616,GO:0050431,GO:0061045,GO:0072675" negative regulation of protein phosphorylation|hair follicle development|platelet degranulation|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|cytosol|plasma membrane|cell surface|negative regulation of keratinocyte proliferation|negative regulation of endopeptidase activity|negative regulation of transforming growth factor beta receptor signaling pathway|platelet alpha granule membrane|anchored component of membrane|regulation of keratinocyte differentiation|transforming growth factor beta binding|negative regulation of wound healing|osteoclast fusion CD14 97.20368376 111.6451565 82.76221099 0.741296923 -0.431876572 0.532919839 1 3.702968774 2.863242797 929 CD14 molecule "GO:0001530,GO:0001847,GO:0002224,GO:0002755,GO:0002756,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0005886,GO:0006898,GO:0006909,GO:0006915,GO:0006954,GO:0007166,GO:0007249,GO:0009408,GO:0009897,GO:0010008,GO:0016019,GO:0030667,GO:0031362,GO:0031663,GO:0032026,GO:0032481,GO:0032729,GO:0032757,GO:0032760,GO:0034128,GO:0034142,GO:0034612,GO:0035666,GO:0038123,GO:0038124,GO:0043312,GO:0045087,GO:0045121,GO:0045471,GO:0045807,GO:0046696,GO:0051602,GO:0070062,GO:0070266,GO:0070891,GO:0071219,GO:0071222,GO:0071223,GO:0071723,GO:0071726,GO:0071727,GO:0097190,GO:1901224" lipopolysaccharide binding|opsonin receptor activity|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|protein binding|extracellular region|extracellular space|Golgi apparatus|plasma membrane|receptor-mediated endocytosis|phagocytosis|apoptotic process|inflammatory response|cell surface receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|response to heat|external side of plasma membrane|endosome membrane|peptidoglycan immune receptor activity|secretory granule membrane|anchored component of external side of plasma membrane|lipopolysaccharide-mediated signaling pathway|response to magnesium ion|positive regulation of type I interferon production|positive regulation of interferon-gamma production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 4 signaling pathway|response to tumor necrosis factor|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|neutrophil degranulation|innate immune response|membrane raft|response to ethanol|positive regulation of endocytosis|lipopolysaccharide receptor complex|response to electrical stimulus|extracellular exosome|necroptotic process|lipoteichoic acid binding|cellular response to molecule of bacterial origin|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|lipopeptide binding|cellular response to diacyl bacterial lipopeptide|cellular response to triacyl bacterial lipopeptide|apoptotic signaling pathway|positive regulation of NIK/NF-kappaB signaling "hsa04010,hsa04064,hsa04145,hsa04620,hsa04640,hsa05131,hsa05132,hsa05133,hsa05134,hsa05146,hsa05152,hsa05202,hsa05221" MAPK signaling pathway|NF-kappa B signaling pathway|Phagosome|Toll-like receptor signaling pathway|Hematopoietic cell lineage|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Amoebiasis|Tuberculosis|Transcriptional misregulation in cancer|Acute myeloid leukemia CD151 7411.214887 7211.262155 7611.167618 1.055455682 0.077866002 0.813048351 1 225.4475237 248.1997853 977 CD151 molecule (Raph blood group) "GO:0005178,GO:0005515,GO:0005604,GO:0005829,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0009986,GO:0016020,GO:0016032,GO:0016477,GO:0030335,GO:0031581,GO:0042098,GO:0044319,GO:0045807" "integrin binding|protein binding|basement membrane|cytosol|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|cell surface|membrane|viral process|cell migration|positive regulation of cell migration|hemidesmosome assembly|T cell proliferation|wound healing, spreading of cells|positive regulation of endocytosis" CD163L1 639.8208666 598.8240213 680.8177118 1.136924518 0.185136475 0.632772087 1 4.767105337 5.653303619 283316 CD163 molecule like 1 "GO:0005044,GO:0005576,GO:0006897,GO:0009897,GO:0016021" scavenger receptor activity|extracellular region|endocytosis|external side of plasma membrane|integral component of membrane CD164 3184.284543 3496.523311 2872.045774 0.821400437 -0.283842381 0.372281442 1 54.38776742 46.59851649 8763 CD164 molecule "GO:0005515,GO:0005576,GO:0005764,GO:0005765,GO:0005768,GO:0005886,GO:0005887,GO:0006955,GO:0007155,GO:0007157,GO:0007162,GO:0007165,GO:0007275,GO:0007517,GO:0008285,GO:0010008,GO:0030097,GO:0031410" protein binding|extracellular region|lysosome|lysosomal membrane|endosome|plasma membrane|integral component of plasma membrane|immune response|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|negative regulation of cell adhesion|signal transduction|multicellular organism development|muscle organ development|negative regulation of cell population proliferation|endosome membrane|hemopoiesis|cytoplasmic vesicle hsa04142 Lysosome CD177 15.20949375 29.43372308 0.985264417 0.033473999 -4.900815276 0.002514159 0.163047409 0.528247427 0.018444247 57126 CD177 molecule "GO:0002020,GO:0005178,GO:0005515,GO:0005886,GO:0007155,GO:0007159,GO:0007596,GO:0030027,GO:0030100,GO:0030667,GO:0032930,GO:0034394,GO:0035579,GO:0043312,GO:0043315,GO:0044853,GO:0045087,GO:0045217,GO:0046658,GO:0048306,GO:0050900,GO:0070062,GO:0070821,GO:0072672,GO:0098742,GO:1990266,GO:2001044" protease binding|integrin binding|protein binding|plasma membrane|cell adhesion|leukocyte cell-cell adhesion|blood coagulation|lamellipodium|regulation of endocytosis|secretory granule membrane|positive regulation of superoxide anion generation|protein localization to cell surface|specific granule membrane|neutrophil degranulation|positive regulation of neutrophil degranulation|plasma membrane raft|innate immune response|cell-cell junction maintenance|anchored component of plasma membrane|calcium-dependent protein binding|leukocyte migration|extracellular exosome|tertiary granule membrane|neutrophil extravasation|cell-cell adhesion via plasma-membrane adhesion molecules|neutrophil migration|regulation of integrin-mediated signaling pathway CD200 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.054086938 4345 CD200 molecule "GO:0002695,GO:0005515,GO:0005886,GO:0005887,GO:0008285,GO:0009986,GO:0016020,GO:0030424,GO:0032088,GO:0032715,GO:0032793,GO:0034113,GO:0043005,GO:0043025,GO:0043031,GO:0044297,GO:0050776,GO:0071636,GO:0086080,GO:0098609,GO:0140081,GO:0150072,GO:0150074,GO:0150077,GO:0150079,GO:1901215,GO:1904465,GO:1905522,GO:2000405" negative regulation of leukocyte activation|protein binding|plasma membrane|integral component of plasma membrane|negative regulation of cell population proliferation|cell surface|membrane|axon|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-6 production|positive regulation of CREB transcription factor activity|heterotypic cell-cell adhesion|neuron projection|neuronal cell body|negative regulation of macrophage activation|cell body|regulation of immune response|positive regulation of transforming growth factor beta production|protein binding involved in heterotypic cell-cell adhesion|cell-cell adhesion|glycosylated region protein binding|positive regulation of arginase activity|positive regulation of protein-glutamine gamma-glutamyltransferase activity|regulation of neuroinflammatory response|negative regulation of neuroinflammatory response|negative regulation of neuron death|negative regulation of matrix metallopeptidase secretion|negative regulation of macrophage migration|negative regulation of T cell migration CD207 24.33197329 13.19442759 35.469519 2.688219611 1.426651002 0.179504117 1 0.219458526 0.615365482 50489 CD207 molecule "GO:0002479,GO:0005515,GO:0005537,GO:0005886,GO:0006898,GO:0016021,GO:0030139,GO:0030246,GO:0030669,GO:0031901,GO:0051607" "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|mannose binding|plasma membrane|receptor-mediated endocytosis|integral component of membrane|endocytic vesicle|carbohydrate binding|clathrin-coated endocytic vesicle membrane|early endosome membrane|defense response to virus" CD226 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.018161369 0.003677902 10666 CD226 molecule "GO:0001816,GO:0002729,GO:0002860,GO:0002891,GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007165,GO:0008037,GO:0009897,GO:0009986,GO:0019901,GO:0032729,GO:0033005,GO:0045121,GO:0045954,GO:0050776,GO:0050839,GO:0050862,GO:0060369" cytokine production|positive regulation of natural killer cell cytokine production|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of immunoglobulin mediated immune response|integrin binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|signal transduction|cell recognition|external side of plasma membrane|cell surface|protein kinase binding|positive regulation of interferon-gamma production|positive regulation of mast cell activation|membrane raft|positive regulation of natural killer cell mediated cytotoxicity|regulation of immune response|cell adhesion molecule binding|positive regulation of T cell receptor signaling pathway|positive regulation of Fc receptor mediated stimulatory signaling pathway hsa04514 Cell adhesion molecules CD24 98.46161534 62.92727004 133.9959607 2.129378258 1.09043225 0.111261781 1 1.01692541 2.258696319 100133941 CD24 molecule "GO:0001666,GO:0001775,GO:0001959,GO:0002237,GO:0002768,GO:0005515,GO:0007204,GO:0009986,GO:0016020,GO:0016055,GO:0016477,GO:0019901,GO:0030296,GO:0030856,GO:0031295,GO:0031362,GO:0032597,GO:0032600,GO:0032913,GO:0042104,GO:0042325,GO:0042632,GO:0043406,GO:0043408,GO:0043627,GO:0045121,GO:0045730,GO:0061098,GO:0072112,GO:0072139,GO:0097193,GO:0098609,GO:2000768" response to hypoxia|cell activation|regulation of cytokine-mediated signaling pathway|response to molecule of bacterial origin|immune response-regulating cell surface receptor signaling pathway|protein binding|positive regulation of cytosolic calcium ion concentration|cell surface|membrane|Wnt signaling pathway|cell migration|protein kinase binding|protein tyrosine kinase activator activity|regulation of epithelial cell differentiation|T cell costimulation|anchored component of external side of plasma membrane|B cell receptor transport into membrane raft|chemokine receptor transport out of membrane raft|negative regulation of transforming growth factor beta3 production|positive regulation of activated T cell proliferation|regulation of phosphorylation|cholesterol homeostasis|positive regulation of MAP kinase activity|regulation of MAPK cascade|response to estrogen|membrane raft|respiratory burst|positive regulation of protein tyrosine kinase activity|glomerular visceral epithelial cell differentiation|glomerular parietal epithelial cell differentiation|intrinsic apoptotic signaling pathway|cell-cell adhesion|positive regulation of nephron tubule epithelial cell differentiation hsa04640 Hematopoietic cell lineage CD274 222.4455877 186.7518982 258.1392771 1.382257849 0.467026764 0.370963422 1 2.52154754 3.63556702 29126 CD274 molecule "GO:0002250,GO:0002845,GO:0005515,GO:0005654,GO:0005886,GO:0006955,GO:0007165,GO:0007166,GO:0009897,GO:0015629,GO:0016021,GO:0030335,GO:0031295,GO:0031901,GO:0032689,GO:0032693,GO:0032733,GO:0034097,GO:0042102,GO:0042130,GO:0046006,GO:0046007,GO:0055038,GO:0070062,GO:0070232,GO:0071222,GO:1901998,GO:1903556,GO:1905399,GO:1905404,GO:2000562,GO:2001186" "adaptive immune response|positive regulation of tolerance induction to tumor cell|protein binding|nucleoplasm|plasma membrane|immune response|signal transduction|cell surface receptor signaling pathway|external side of plasma membrane|actin cytoskeleton|integral component of membrane|positive regulation of cell migration|T cell costimulation|early endosome membrane|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|positive regulation of interleukin-10 production|response to cytokine|positive regulation of T cell proliferation|negative regulation of T cell proliferation|regulation of activated T cell proliferation|negative regulation of activated T cell proliferation|recycling endosome membrane|extracellular exosome|regulation of T cell apoptotic process|cellular response to lipopolysaccharide|toxin transport|negative regulation of tumor necrosis factor superfamily cytokine production|regulation of activated CD4-positive, alpha-beta T cell apoptotic process|positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process|negative regulation of CD4-positive, alpha-beta T cell proliferation|negative regulation of CD8-positive, alpha-beta T cell activation" "hsa04514,hsa05235" Cell adhesion molecules|PD-L1 expression and PD-1 checkpoint pathway in cancer CD276 3220.187311 3492.463487 2947.911134 0.844077868 -0.244551998 0.442078 1 46.65812581 41.07955521 80381 CD276 molecule "GO:0001817,GO:0005102,GO:0005515,GO:0009897,GO:0016021,GO:0032729,GO:0042102,GO:0042110,GO:0050776,GO:0050852" regulation of cytokine production|signaling receptor binding|protein binding|external side of plasma membrane|integral component of membrane|positive regulation of interferon-gamma production|positive regulation of T cell proliferation|T cell activation|regulation of immune response|T cell receptor signaling pathway hsa04514 Cell adhesion molecules CD2AP 1292.385344 1260.575313 1324.195376 1.05046907 0.071033683 0.835573691 1 11.14006152 12.20637725 23607 CD2 associated protein "GO:0001650,GO:0001726,GO:0005172,GO:0005200,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006930,GO:0007015,GO:0007049,GO:0007165,GO:0008013,GO:0008022,GO:0015629,GO:0016050,GO:0017124,GO:0030139,GO:0030424,GO:0030425,GO:0031941,GO:0032911,GO:0034451,GO:0042802,GO:0043161,GO:0044877,GO:0045296,GO:0048259,GO:0048471,GO:0050714,GO:0051058,GO:0051301,GO:0065003,GO:0070062,GO:0098609,GO:1900182,GO:2000249" "fibrillar center|ruffle|vascular endothelial growth factor receptor binding|structural constituent of cytoskeleton|protein binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|substrate-dependent cell migration, cell extension|actin filament organization|cell cycle|signal transduction|beta-catenin binding|protein C-terminus binding|actin cytoskeleton|vesicle organization|SH3 domain binding|endocytic vesicle|axon|dendrite|filamentous actin|negative regulation of transforming growth factor beta1 production|centriolar satellite|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|cadherin binding|regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|positive regulation of protein secretion|negative regulation of small GTPase mediated signal transduction|cell division|protein-containing complex assembly|extracellular exosome|cell-cell adhesion|positive regulation of protein localization to nucleus|regulation of actin cytoskeleton reorganization" hsa05100 Bacterial invasion of epithelial cells CD2BP2 1507.043334 1386.429853 1627.656816 1.173991467 0.231421922 0.485308604 1 19.57017308 23.96489533 10421 CD2 cytoplasmic tail binding protein 2 "GO:0000244,GO:0000398,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005682,GO:0005737,GO:0005829,GO:0010923,GO:0016607,GO:0043021,GO:0046540" "spliceosomal tri-snRNP complex assembly|mRNA splicing, via spliceosome|fibrillar center|protein binding|nucleus|nucleoplasm|U5 snRNP|cytoplasm|cytosol|negative regulation of phosphatase activity|nuclear speck|ribonucleoprotein complex binding|U4/U6 x U5 tri-snRNP complex" CD302 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.065366149 0.039712358 9936 CD302 molecule "GO:0005515,GO:0005902,GO:0005938,GO:0006909,GO:0009897,GO:0016020,GO:0016021,GO:0030175,GO:0030246,GO:0038023" protein binding|microvillus|cell cortex|phagocytosis|external side of plasma membrane|membrane|integral component of membrane|filopodium|carbohydrate binding|signaling receptor activity CD320 613.5938311 759.1870643 468.0005979 0.616449647 -0.697945038 0.073219256 1 30.68646972 19.73151657 51293 CD320 molecule "GO:0005509,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0007165,GO:0008083,GO:0009235,GO:0010008,GO:0015420,GO:0015889,GO:0016020,GO:0030890,GO:0031296,GO:0031419" calcium ion binding|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|signal transduction|growth factor activity|cobalamin metabolic process|endosome membrane|ATPase-coupled vitamin B12 transmembrane transporter activity|cobalamin transport|membrane|positive regulation of B cell proliferation|B cell costimulation|cobalamin binding CD34 7.030462899 9.134603715 4.926322083 0.539303317 -0.890831188 0.625563046 1 0.056667743 0.03187755 947 CD34 molecule "GO:0001894,GO:0001935,GO:0003094,GO:0003158,GO:0005515,GO:0005737,GO:0005764,GO:0005886,GO:0005887,GO:0007160,GO:0007165,GO:0008134,GO:0008217,GO:0009897,GO:0009925,GO:0010628,GO:0010629,GO:0016324,GO:0030097,GO:0030195,GO:0030246,GO:0032703,GO:0032720,GO:0032733,GO:0035759,GO:0036053,GO:0038001,GO:0042482,GO:0043199,GO:0045019,GO:0045171,GO:0045766,GO:0048471,GO:0048870,GO:0050776,GO:0050900,GO:0060290,GO:0061042,GO:0071425,GO:0071636,GO:0071657,GO:0071971,GO:0072011,GO:0072089,GO:0072254,GO:0098609,GO:1900035,GO:1900038,GO:1900168,GO:1901215,GO:2001214" tissue homeostasis|endothelial cell proliferation|glomerular filtration|endothelium development|protein binding|cytoplasm|lysosome|plasma membrane|integral component of plasma membrane|cell-matrix adhesion|signal transduction|transcription factor binding|regulation of blood pressure|external side of plasma membrane|basal plasma membrane|positive regulation of gene expression|negative regulation of gene expression|apical plasma membrane|hemopoiesis|negative regulation of blood coagulation|carbohydrate binding|negative regulation of interleukin-2 production|negative regulation of tumor necrosis factor production|positive regulation of interleukin-10 production|mesangial cell-matrix adhesion|glomerular endothelium fenestra|paracrine signaling|positive regulation of odontogenesis|sulfate binding|negative regulation of nitric oxide biosynthetic process|intercellular bridge|positive regulation of angiogenesis|perinuclear region of cytoplasm|cell motility|regulation of immune response|leukocyte migration|transdifferentiation|vascular wound healing|hematopoietic stem cell proliferation|positive regulation of transforming growth factor beta production|positive regulation of granulocyte colony-stimulating factor production|extracellular exosome assembly|glomerular endothelium development|stem cell proliferation|metanephric glomerular mesangial cell differentiation|cell-cell adhesion|negative regulation of cellular response to heat|negative regulation of cellular response to hypoxia|positive regulation of glial cell-derived neurotrophic factor production|negative regulation of neuron death|positive regulation of vasculogenesis "hsa04514,hsa04640" Cell adhesion molecules|Hematopoietic cell lineage CD40 1495.346846 1664.527788 1326.165905 0.796721998 -0.327851686 0.323022621 1 48.06297626 39.9423303 958 CD40 molecule "GO:0001934,GO:0002768,GO:0003823,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006874,GO:0006954,GO:0009897,GO:0009986,GO:0019899,GO:0019904,GO:0023035,GO:0030168,GO:0030890,GO:0031625,GO:0032735,GO:0033209,GO:0033590,GO:0034341,GO:0035631,GO:0035666,GO:0036018,GO:0038023,GO:0042100,GO:0042113,GO:0042531,GO:0042832,GO:0043025,GO:0043123,GO:0043196,GO:0043231,GO:0043406,GO:0043491,GO:0043536,GO:0043547,GO:0045766,GO:0045944,GO:0048304,GO:0050776,GO:0051092,GO:0051607,GO:0065003,GO:0070062,GO:0071222,GO:0071260,GO:0071347,GO:0071356,GO:0090037,GO:1901652,GO:2000353" positive regulation of protein phosphorylation|immune response-regulating cell surface receptor signaling pathway|antigen binding|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|inflammatory response|external side of plasma membrane|cell surface|enzyme binding|protein domain specific binding|CD40 signaling pathway|platelet activation|positive regulation of B cell proliferation|ubiquitin protein ligase binding|positive regulation of interleukin-12 production|tumor necrosis factor-mediated signaling pathway|response to cobalamin|response to interferon-gamma|CD40 receptor complex|TRIF-dependent toll-like receptor signaling pathway|cellular response to erythropoietin|signaling receptor activity|B cell proliferation|B cell activation|positive regulation of tyrosine phosphorylation of STAT protein|defense response to protozoan|neuronal cell body|positive regulation of I-kappaB kinase/NF-kappaB signaling|varicosity|intracellular membrane-bounded organelle|positive regulation of MAP kinase activity|protein kinase B signaling|positive regulation of blood vessel endothelial cell migration|positive regulation of GTPase activity|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of isotype switching to IgG isotypes|regulation of immune response|positive regulation of NF-kappaB transcription factor activity|defense response to virus|protein-containing complex assembly|extracellular exosome|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to interleukin-1|cellular response to tumor necrosis factor|positive regulation of protein kinase C signaling|response to peptide|positive regulation of endothelial cell apoptotic process "hsa04060,hsa04064,hsa04514,hsa04620,hsa04672,hsa05144,hsa05145,hsa05166,hsa05169,hsa05202,hsa05310,hsa05320,hsa05322,hsa05330,hsa05340,hsa05416" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Cell adhesion molecules|Toll-like receptor signaling pathway|Intestinal immune network for IgA production|Malaria|Toxoplasmosis|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Transcriptional misregulation in cancer|Asthma|Autoimmune thyroid disease|Systemic lupus erythematosus|Allograft rejection|Primary immunodeficiency|Viral myocarditis CD44 26023.88612 26546.17335 25501.59889 0.960650658 -0.057916207 0.878666853 1 190.5158043 190.9028547 960 CD44 molecule (Indian blood group) "GO:0004888,GO:0004896,GO:0005515,GO:0005518,GO:0005540,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0005902,GO:0005925,GO:0006954,GO:0007155,GO:0007160,GO:0009986,GO:0016323,GO:0016324,GO:0016477,GO:0022617,GO:0030198,GO:0030214,GO:0030667,GO:0031258,GO:0033138,GO:0034116,GO:0035692,GO:0042110,GO:0042995,GO:0043066,GO:0043154,GO:0043312,GO:0043518,GO:0044319,GO:0044344,GO:0050731,GO:0050900,GO:0051216,GO:0060333,GO:0070062,GO:0070374,GO:0070487,GO:0098609,GO:1900625,GO:1902166,GO:2000392" "transmembrane signaling receptor activity|cytokine receptor activity|protein binding|collagen binding|hyaluronic acid binding|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|microvillus|focal adhesion|inflammatory response|cell adhesion|cell-matrix adhesion|cell surface|basolateral plasma membrane|apical plasma membrane|cell migration|extracellular matrix disassembly|extracellular matrix organization|hyaluronan catabolic process|secretory granule membrane|lamellipodium membrane|positive regulation of peptidyl-serine phosphorylation|positive regulation of heterotypic cell-cell adhesion|macrophage migration inhibitory factor receptor complex|T cell activation|cell projection|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|negative regulation of DNA damage response, signal transduction by p53 class mediator|wound healing, spreading of cells|cellular response to fibroblast growth factor stimulus|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|cartilage development|interferon-gamma-mediated signaling pathway|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|monocyte aggregation|cell-cell adhesion|positive regulation of monocyte aggregation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of lamellipodium morphogenesis" "hsa04512,hsa04640,hsa05131,hsa05169,hsa05205,hsa05206" ECM-receptor interaction|Hematopoietic cell lineage|Shigellosis|Epstein-Barr virus infection|Proteoglycans in cancer|MicroRNAs in cancer CD46 3851.01881 2836.801932 4865.235689 1.715042434 0.778244272 0.015022835 0.541541234 42.40673264 75.86223122 4179 CD46 molecule "GO:0001618,GO:0002079,GO:0002250,GO:0002456,GO:0005515,GO:0005886,GO:0005887,GO:0005925,GO:0006958,GO:0007338,GO:0008593,GO:0009986,GO:0010628,GO:0010629,GO:0030449,GO:0032613,GO:0032733,GO:0035581,GO:0038023,GO:0042102,GO:0043382,GO:0045087,GO:0045296,GO:0045591,GO:0046718,GO:0070062,GO:0071636" "virus receptor activity|inner acrosomal membrane|adaptive immune response|T cell mediated immunity|protein binding|plasma membrane|integral component of plasma membrane|focal adhesion|complement activation, classical pathway|single fertilization|regulation of Notch signaling pathway|cell surface|positive regulation of gene expression|negative regulation of gene expression|regulation of complement activation|interleukin-10 production|positive regulation of interleukin-10 production|sequestering of extracellular ligand from receptor|signaling receptor activity|positive regulation of T cell proliferation|positive regulation of memory T cell differentiation|innate immune response|cadherin binding|positive regulation of regulatory T cell differentiation|viral entry into host cell|extracellular exosome|positive regulation of transforming growth factor beta production" "hsa04610,hsa05162" Complement and coagulation cascades|Measles CD47 1798.326541 1530.5536 2066.099481 1.349903382 0.432856152 0.183216312 1 7.645442389 10.7651785 961 CD47 molecule "GO:0005515,GO:0005886,GO:0005887,GO:0007229,GO:0008284,GO:0009986,GO:0016477,GO:0022409,GO:0030198,GO:0032649,GO:0032653,GO:0032655,GO:0032675,GO:0032680,GO:0034113,GO:0035579,GO:0035696,GO:0043312,GO:0045428,GO:0050729,GO:0050766,GO:0050870,GO:0050900,GO:0051496,GO:0070053,GO:0070062,GO:0070821,GO:0071346,GO:0071347,GO:0071349,GO:0086080,GO:0098632,GO:1904669,GO:1905450" protein binding|plasma membrane|integral component of plasma membrane|integrin-mediated signaling pathway|positive regulation of cell population proliferation|cell surface|cell migration|positive regulation of cell-cell adhesion|extracellular matrix organization|regulation of interferon-gamma production|regulation of interleukin-10 production|regulation of interleukin-12 production|regulation of interleukin-6 production|regulation of tumor necrosis factor production|heterotypic cell-cell adhesion|specific granule membrane|monocyte extravasation|neutrophil degranulation|regulation of nitric oxide biosynthetic process|positive regulation of inflammatory response|positive regulation of phagocytosis|positive regulation of T cell activation|leukocyte migration|positive regulation of stress fiber assembly|thrombospondin receptor activity|extracellular exosome|tertiary granule membrane|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to interleukin-12|protein binding involved in heterotypic cell-cell adhesion|cell-cell adhesion mediator activity|ATP export|negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis hsa04512 ECM-receptor interaction CD55 572.2857167 595.7791534 548.79228 0.92113374 -0.118517457 0.767531545 1 9.149215385 8.790680014 1604 CD55 molecule (Cromer blood group) "GO:0000139,GO:0001618,GO:0005515,GO:0005576,GO:0005886,GO:0006888,GO:0006958,GO:0007204,GO:0008289,GO:0009986,GO:0030133,GO:0030449,GO:0030667,GO:0031225,GO:0031664,GO:0033116,GO:0035743,GO:0043312,GO:0045087,GO:0045121,GO:0045730,GO:0045916,GO:0046718,GO:0070062,GO:0101003,GO:1903659,GO:2000516,GO:2000563" "Golgi membrane|virus receptor activity|protein binding|extracellular region|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|complement activation, classical pathway|positive regulation of cytosolic calcium ion concentration|lipid binding|cell surface|transport vesicle|regulation of complement activation|secretory granule membrane|anchored component of membrane|regulation of lipopolysaccharide-mediated signaling pathway|endoplasmic reticulum-Golgi intermediate compartment membrane|CD4-positive, alpha-beta T cell cytokine production|neutrophil degranulation|innate immune response|membrane raft|respiratory burst|negative regulation of complement activation|viral entry into host cell|extracellular exosome|ficolin-1-rich granule membrane|regulation of complement-dependent cytotoxicity|positive regulation of CD4-positive, alpha-beta T cell activation|positive regulation of CD4-positive, alpha-beta T cell proliferation" "hsa04610,hsa04640,hsa05416" Complement and coagulation cascades|Hematopoietic cell lineage|Viral myocarditis CD58 375.6027401 452.6703619 298.5351182 0.659497823 -0.600560198 0.17408294 1 3.600778531 2.476998289 965 CD58 molecule "GO:0005102,GO:0005515,GO:0005886,GO:0005887,GO:0009986,GO:0016020,GO:0030667,GO:0032757,GO:0034113,GO:0043312,GO:0050900,GO:0070062,GO:0071346,GO:0071356,GO:0098609,GO:0101003" signaling receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell surface|membrane|secretory granule membrane|positive regulation of interleukin-8 production|heterotypic cell-cell adhesion|neutrophil degranulation|leukocyte migration|extracellular exosome|cellular response to interferon-gamma|cellular response to tumor necrosis factor|cell-cell adhesion|ficolin-1-rich granule membrane "hsa04514,hsa05169" Cell adhesion molecules|Epstein-Barr virus infection CD59 11568.51385 9163.022482 13974.00522 1.52504321 0.60885012 0.074996446 1 57.85746958 92.03595317 966 CD59 molecule (CD59 blood group) "GO:0000139,GO:0001848,GO:0001971,GO:0005515,GO:0005615,GO:0005789,GO:0005886,GO:0005925,GO:0006888,GO:0007166,GO:0007596,GO:0009986,GO:0012507,GO:0016020,GO:0030133,GO:0030449,GO:0031362,GO:0031982,GO:0033116,GO:0035579,GO:0043312,GO:0048208,GO:0070062,GO:0070821,GO:1903659" Golgi membrane|complement binding|negative regulation of activation of membrane attack complex|protein binding|extracellular space|endoplasmic reticulum membrane|plasma membrane|focal adhesion|endoplasmic reticulum to Golgi vesicle-mediated transport|cell surface receptor signaling pathway|blood coagulation|cell surface|ER to Golgi transport vesicle membrane|membrane|transport vesicle|regulation of complement activation|anchored component of external side of plasma membrane|vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|specific granule membrane|neutrophil degranulation|COPII vesicle coating|extracellular exosome|tertiary granule membrane|regulation of complement-dependent cytotoxicity "hsa04610,hsa04640" Complement and coagulation cascades|Hematopoietic cell lineage CD63 10282.18064 9663.395775 10900.9655 1.128067789 0.173853766 0.606277649 1 266.7122101 313.829689 967 CD63 molecule "GO:0002092,GO:0002576,GO:0005515,GO:0005615,GO:0005654,GO:0005765,GO:0005886,GO:0005887,GO:0007160,GO:0009986,GO:0010008,GO:0015031,GO:0016477,GO:0031088,GO:0031226,GO:0031902,GO:0031904,GO:0032585,GO:0034613,GO:0035577,GO:0035646,GO:0042470,GO:0043231,GO:0043312,GO:0048757,GO:0070062,GO:0097487,GO:1900746,GO:1901379,GO:2001046" "positive regulation of receptor internalization|platelet degranulation|protein binding|extracellular space|nucleoplasm|lysosomal membrane|plasma membrane|integral component of plasma membrane|cell-matrix adhesion|cell surface|endosome membrane|protein transport|cell migration|platelet dense granule membrane|intrinsic component of plasma membrane|late endosome membrane|endosome lumen|multivesicular body membrane|cellular protein localization|azurophil granule membrane|endosome to melanosome transport|melanosome|intracellular membrane-bounded organelle|neutrophil degranulation|pigment granule maturation|extracellular exosome|multivesicular body, internal vesicle|regulation of vascular endothelial growth factor signaling pathway|regulation of potassium ion transmembrane transport|positive regulation of integrin-mediated signaling pathway" "hsa04142,hsa05205" Lysosome|Proteoglycans in cancer CD68 425.91333 423.2366388 428.5900212 1.012648674 0.018133736 0.972141383 1 12.57210714 13.27953297 968 CD68 molecule "GO:0002437,GO:0002605,GO:0005515,GO:0005764,GO:0005765,GO:0005886,GO:0007568,GO:0016020,GO:0016021,GO:0031669,GO:0031902,GO:0035425,GO:0035577,GO:0043312,GO:0071222,GO:0072594,GO:0140052" inflammatory response to antigenic stimulus|negative regulation of dendritic cell antigen processing and presentation|protein binding|lysosome|lysosomal membrane|plasma membrane|aging|membrane|integral component of membrane|cellular response to nutrient levels|late endosome membrane|autocrine signaling|azurophil granule membrane|neutrophil degranulation|cellular response to lipopolysaccharide|establishment of protein localization to organelle|cellular response to oxidised low-density lipoprotein particle stimulus hsa04142 Lysosome CD69 65.52676467 101.4955968 29.5579325 0.291223791 -1.779799875 0.02536749 0.707471111 3.067060814 0.931676558 969 CD69 molecule "GO:0004888,GO:0005509,GO:0005515,GO:0005887,GO:0009897,GO:0030246,GO:0032991,GO:0042802" transmembrane signaling receptor activity|calcium ion binding|protein binding|integral component of plasma membrane|external side of plasma membrane|carbohydrate binding|protein-containing complex|identical protein binding CD7 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.119358992 0.201430587 924 CD7 molecule "GO:0002250,GO:0005515,GO:0005886,GO:0006955,GO:0007169,GO:0016020,GO:0016021,GO:0038023,GO:0042110" adaptive immune response|protein binding|plasma membrane|immune response|transmembrane receptor protein tyrosine kinase signaling pathway|membrane|integral component of membrane|signaling receptor activity|T cell activation hsa04640 Hematopoietic cell lineage CD70 900.961466 1140.810508 661.1124235 0.579511162 -0.787091645 0.028894392 0.757968522 21.07149078 12.73717153 970 CD70 molecule "GO:0002020,GO:0002456,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0007267,GO:0019724,GO:0033209,GO:0042100,GO:0042102,GO:0070062,GO:0097191" protease binding|T cell mediated immunity|signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|cell-cell signaling|B cell mediated immunity|tumor necrosis factor-mediated signaling pathway|B cell proliferation|positive regulation of T cell proliferation|extracellular exosome|extrinsic apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction CD72 13.44952738 10.14955968 16.74949508 1.65026815 0.722700465 0.594168303 1 0.335534851 0.577574597 971 CD72 molecule "GO:0004888,GO:0005102,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0030246" transmembrane signaling receptor activity|signaling receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|carbohydrate binding hsa04662 B cell receptor signaling pathway CD74 393.1499477 372.4888404 413.8110549 1.110935443 0.151774984 0.731541315 1 5.533952979 6.412689574 972 CD74 molecule "GO:0000139,GO:0000187,GO:0001516,GO:0001540,GO:0001934,GO:0001961,GO:0002286,GO:0002606,GO:0002792,GO:0002830,GO:0002906,GO:0004896,GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005771,GO:0005773,GO:0005886,GO:0006886,GO:0008283,GO:0009897,GO:0009986,GO:0010628,GO:0012507,GO:0016020,GO:0016021,GO:0016064,GO:0019882,GO:0019883,GO:0019886,GO:0019955,GO:0023026,GO:0030336,GO:0030658,GO:0030666,GO:0030669,GO:0030890,GO:0031394,GO:0032588,GO:0032722,GO:0032755,GO:0032757,GO:0032991,GO:0033674,GO:0034341,GO:0035691,GO:0035692,GO:0035693,GO:0035718,GO:0042289,GO:0042609,GO:0042613,GO:0042658,GO:0042802,GO:0043030,GO:0043066,GO:0043123,GO:0043202,GO:0043410,GO:0043518,GO:0044183,GO:0045058,GO:0045059,GO:0045060,GO:0045581,GO:0045582,GO:0045657,GO:0045893,GO:0046598,GO:0048146,GO:0050731,GO:0050900,GO:0050998,GO:0051085,GO:0060907,GO:0065003,GO:0070062,GO:0070206,GO:0070374,GO:0071556,GO:0090023,GO:1902166,GO:2000343,GO:2000448" "Golgi membrane|activation of MAPK activity|prostaglandin biosynthetic process|amyloid-beta binding|positive regulation of protein phosphorylation|positive regulation of cytokine-mediated signaling pathway|T cell activation involved in immune response|positive regulation of dendritic cell antigen processing and presentation|negative regulation of peptide secretion|positive regulation of type 2 immune response|negative regulation of mature B cell apoptotic process|cytokine receptor activity|protein binding|nucleus|cytoplasm|lysosomal membrane|multivesicular body|vacuole|plasma membrane|intracellular protein transport|cell population proliferation|external side of plasma membrane|cell surface|positive regulation of gene expression|ER to Golgi transport vesicle membrane|membrane|integral component of membrane|immunoglobulin mediated immune response|antigen processing and presentation|antigen processing and presentation of endogenous antigen|antigen processing and presentation of exogenous peptide antigen via MHC class II|cytokine binding|MHC class II protein complex binding|negative regulation of cell migration|transport vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|positive regulation of B cell proliferation|positive regulation of prostaglandin biosynthetic process|trans-Golgi network membrane|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|protein-containing complex|positive regulation of kinase activity|response to interferon-gamma|macrophage migration inhibitory factor signaling pathway|macrophage migration inhibitory factor receptor complex|NOS2-CD74 complex|macrophage migration inhibitory factor binding|MHC class II protein binding|CD4 receptor binding|MHC class II protein complex|MHC class II protein binding, via antigen binding groove|identical protein binding|regulation of macrophage activation|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|lysosomal lumen|positive regulation of MAPK cascade|negative regulation of DNA damage response, signal transduction by p53 class mediator|protein folding chaperone|T cell selection|positive thymic T cell selection|negative thymic T cell selection|negative regulation of T cell differentiation|positive regulation of T cell differentiation|positive regulation of monocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of viral entry into host cell|positive regulation of fibroblast proliferation|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|nitric-oxide synthase binding|chaperone cofactor-dependent protein refolding|positive regulation of macrophage cytokine production|protein-containing complex assembly|extracellular exosome|protein trimerization|positive regulation of ERK1 and ERK2 cascade|integral component of lumenal side of endoplasmic reticulum membrane|positive regulation of neutrophil chemotaxis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of macrophage migration inhibitory factor signaling pathway" "hsa04612,hsa05152,hsa05168" Antigen processing and presentation|Tuberculosis|Herpes simplex virus 1 infection CD81 3305.400805 3087.496056 3523.305554 1.141153054 0.190492302 0.549441908 1 71.14230355 84.6813455 975 CD81 molecule "GO:0000187,GO:0001618,GO:0001771,GO:0001772,GO:0002455,GO:0002863,GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0005925,GO:0008104,GO:0008284,GO:0009925,GO:0014905,GO:0015485,GO:0016020,GO:0016021,GO:0016323,GO:0023026,GO:0030449,GO:0030890,GO:0031623,GO:0031647,GO:0031982,GO:0034238,GO:0035783,GO:0042289,GO:0043128,GO:0045944,GO:0046718,GO:0046813,GO:0050731,GO:0050776,GO:0050861,GO:0050862,GO:0061462,GO:0070062,GO:0070863,GO:0071404,GO:0072659,GO:0072675,GO:0097197,GO:1903911,GO:1904352,GO:1905521,GO:1905676,GO:1990459,GO:2000553,GO:2000563,GO:2001190" "activation of MAPK activity|virus receptor activity|immunological synapse formation|immunological synapse|humoral immune response mediated by circulating immunoglobulin|positive regulation of inflammatory response to antigenic stimulus|integrin binding|protein binding|plasma membrane|integral component of plasma membrane|focal adhesion|protein localization|positive regulation of cell population proliferation|basal plasma membrane|myoblast fusion involved in skeletal muscle regeneration|cholesterol binding|membrane|integral component of membrane|basolateral plasma membrane|MHC class II protein complex binding|regulation of complement activation|positive regulation of B cell proliferation|receptor internalization|regulation of protein stability|vesicle|macrophage fusion|CD4-positive, alpha-beta T cell costimulation|MHC class II protein binding|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of transcription by RNA polymerase II|viral entry into host cell|receptor-mediated virion attachment to host cell|positive regulation of peptidyl-tyrosine phosphorylation|regulation of immune response|positive regulation of B cell receptor signaling pathway|positive regulation of T cell receptor signaling pathway|protein localization to lysosome|extracellular exosome|positive regulation of protein exit from endoplasmic reticulum|cellular response to low-density lipoprotein particle stimulus|protein localization to plasma membrane|osteoclast fusion|tetraspanin-enriched microdomain|positive regulation of receptor clustering|positive regulation of protein catabolic process in the vacuole|regulation of macrophage migration|positive regulation of adaptive immune memory response|transferrin receptor binding|positive regulation of T-helper 2 cell cytokine production|positive regulation of CD4-positive, alpha-beta T cell proliferation|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" "hsa04662,hsa05144,hsa05160" B cell receptor signaling pathway|Malaria|Hepatitis C CD82 521.4176683 688.1401466 354.69519 0.515440338 -0.956122648 0.018661211 0.589604582 14.4373947 7.76217023 3732 CD82 molecule "GO:0005515,GO:0005886,GO:0005887,GO:0070062" protein binding|plasma membrane|integral component of plasma membrane|extracellular exosome hsa04115 p53 signaling pathway CD83 131.4152712 160.363043 102.4674993 0.638972031 -0.646175311 0.297499124 1 3.424039798 2.282110044 9308 CD83 molecule "GO:0005515,GO:0005886,GO:0005887,GO:0006952,GO:0006959,GO:0007165,GO:0009897,GO:0014070,GO:0032713,GO:0032733,GO:0032743,GO:0043372" "protein binding|plasma membrane|integral component of plasma membrane|defense response|humoral immune response|signal transduction|external side of plasma membrane|response to organic cyclic compound|negative regulation of interleukin-4 production|positive regulation of interleukin-10 production|positive regulation of interleukin-2 production|positive regulation of CD4-positive, alpha-beta T cell differentiation" CD8A 54.51342838 55.82257826 53.20427849 0.953096044 -0.069306493 0.956982492 1 0.902687311 0.897407995 925 CD8a molecule "GO:0002456,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006955,GO:0007166,GO:0007169,GO:0009897,GO:0015026,GO:0019882,GO:0023024,GO:0042101,GO:0042110,GO:0042288,GO:0044853,GO:0045065,GO:0050776" T cell mediated immunity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|immune response|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|external side of plasma membrane|coreceptor activity|antigen processing and presentation|MHC class I protein complex binding|T cell receptor complex|T cell activation|MHC class I protein binding|plasma membrane raft|cytotoxic T cell differentiation|regulation of immune response "hsa04514,hsa04612,hsa04640,hsa04660,hsa05135,hsa05340" Cell adhesion molecules|Antigen processing and presentation|Hematopoietic cell lineage|T cell receptor signaling pathway|Yersinia infection|Primary immunodeficiency CD9 3055.159972 2886.534774 3223.785171 1.11683573 0.159417002 0.616623181 1 106.9442599 124.5841256 928 CD9 molecule "GO:0002576,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007342,GO:0008347,GO:0014905,GO:0016020,GO:0030168,GO:0030666,GO:0030669,GO:0030913,GO:0031092,GO:0031623,GO:0032991,GO:0035036,GO:0051271,GO:0070062,GO:0071404,GO:0090331,GO:1903561" platelet degranulation|integrin binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|fusion of sperm to egg plasma membrane involved in single fertilization|glial cell migration|myoblast fusion involved in skeletal muscle regeneration|membrane|platelet activation|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|paranodal junction assembly|platelet alpha granule membrane|receptor internalization|protein-containing complex|sperm-egg recognition|negative regulation of cellular component movement|extracellular exosome|cellular response to low-density lipoprotein particle stimulus|negative regulation of platelet aggregation|extracellular vesicle hsa04640 Hematopoietic cell lineage CD99-2 143.2235984 159.348087 127.0991097 0.797619301 -0.326227775 0.592548974 1 1.916964005 1.594870931 4267 CD99 molecule (Xg blood group) CD99L2 2353.457721 2334.398727 2372.516715 1.016328825 0.02336725 0.943080707 1 21.85784069 23.17167502 83692 CD99 molecule like 2 "GO:0005515,GO:0005886,GO:0005912,GO:0005925,GO:0007155,GO:0009986,GO:0016021,GO:0050904,GO:2000391,GO:2000409" protein binding|plasma membrane|adherens junction|focal adhesion|cell adhesion|cell surface|integral component of membrane|diapedesis|positive regulation of neutrophil extravasation|positive regulation of T cell extravasation "hsa04514,hsa04670" Cell adhesion molecules|Leukocyte transendothelial migration CDA 123.8355146 113.6750685 133.9959607 1.178762964 0.237273638 0.715269287 1 7.116490971 8.750005271 978 cytidine deaminase "GO:0001882,GO:0004126,GO:0005515,GO:0005576,GO:0005829,GO:0007166,GO:0008270,GO:0008655,GO:0009972,GO:0019858,GO:0030308,GO:0034774,GO:0042802,GO:0042803,GO:0043097,GO:0043312,GO:0045980,GO:1904724,GO:1904813" nucleoside binding|cytidine deaminase activity|protein binding|extracellular region|cytosol|cell surface receptor signaling pathway|zinc ion binding|pyrimidine-containing compound salvage|cytidine deamination|cytosine metabolic process|negative regulation of cell growth|secretory granule lumen|identical protein binding|protein homodimerization activity|pyrimidine nucleoside salvage|neutrophil degranulation|negative regulation of nucleotide metabolic process|tertiary granule lumen|ficolin-1-rich granule lumen "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes CDADC1 114.2352486 130.9293199 97.54117724 0.744991094 -0.424704917 0.516703971 1 1.621694342 1.26018995 81602 cytidine and dCMP deaminase domain containing 1 "GO:0004126,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0042803,GO:0061676,GO:0070383" cytidine deaminase activity|nucleus|cytoplasm|zinc ion binding|cytidine deamination|protein homodimerization activity|importin-alpha family protein binding|DNA cytosine deamination CDAN1 311.9034897 274.0381115 349.7688679 1.276351183 0.352025336 0.452657454 1 3.042986976 4.051223551 146059 codanin 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006325,GO:0008104,GO:0008156,GO:0012505,GO:0016021,GO:0031497" protein binding|nucleus|cytoplasm|cytosol|plasma membrane|chromatin organization|protein localization|negative regulation of DNA replication|endomembrane system|integral component of membrane|chromatin assembly CDC123 2308.103145 2365.862362 2250.343927 0.9511728 -0.072220635 0.82236327 1 90.70596699 89.99351393 8872 cell division cycle 123 "GO:0005737,GO:0007050,GO:0008284,GO:0045948,GO:0051301,GO:1905143" cytoplasm|cell cycle arrest|positive regulation of cell population proliferation|positive regulation of translational initiation|cell division|eukaryotic translation initiation factor 2 complex assembly CDC14A 276.1222094 252.7240361 299.5203826 1.185167771 0.2450913 0.61720141 1 2.394235105 2.959801303 8556 cell division cycle 14A "GO:0000226,GO:0000278,GO:0000922,GO:0004722,GO:0004725,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0007096,GO:0007605,GO:0008138,GO:0016604,GO:0032426,GO:0032467,GO:0035335,GO:0051301,GO:0060091,GO:0060271,GO:0071850,GO:0072686,GO:0106306,GO:0106307,GO:1902636" microtubule cytoskeleton organization|mitotic cell cycle|spindle pole|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|regulation of exit from mitosis|sensory perception of sound|protein tyrosine/serine/threonine phosphatase activity|nuclear body|stereocilium tip|positive regulation of cytokinesis|peptidyl-tyrosine dephosphorylation|cell division|kinocilium|cilium assembly|mitotic cell cycle arrest|mitotic spindle|protein serine phosphatase activity|protein threonine phosphatase activity|kinociliary basal body hsa04110 Cell cycle CDC14B 812.3836702 877.9369126 746.8304277 0.850665255 -0.233336566 0.525016905 1 5.557356262 4.93108925 8555 cell division cycle 14B "GO:0000226,GO:0000278,GO:0000922,GO:0004722,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0006281,GO:0006470,GO:0007096,GO:0008138,GO:0031572,GO:0032467,GO:0035335,GO:0060271,GO:0071850,GO:0072425,GO:0072686,GO:0106306,GO:0106307,GO:1904668" microtubule cytoskeleton organization|mitotic cell cycle|spindle pole|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|DNA repair|protein dephosphorylation|regulation of exit from mitosis|protein tyrosine/serine/threonine phosphatase activity|G2 DNA damage checkpoint|positive regulation of cytokinesis|peptidyl-tyrosine dephosphorylation|cilium assembly|mitotic cell cycle arrest|signal transduction involved in G2 DNA damage checkpoint|mitotic spindle|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of ubiquitin protein ligase activity hsa04110 Cell cycle CDC14C 12.00132231 12.17947162 11.823173 0.970745971 -0.042834281 1 1 0.212120795 0.214785407 168448 cell division cycle 14C "GO:0000226,GO:0000278,GO:0000922,GO:0004722,GO:0004725,GO:0005730,GO:0005737,GO:0005789,GO:0005813,GO:0007096,GO:0008138,GO:0016021,GO:0031572,GO:0032467,GO:0035335,GO:0060271,GO:0071850,GO:0072686,GO:0106306,GO:0106307" microtubule cytoskeleton organization|mitotic cell cycle|spindle pole|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|nucleolus|cytoplasm|endoplasmic reticulum membrane|centrosome|regulation of exit from mitosis|protein tyrosine/serine/threonine phosphatase activity|integral component of membrane|G2 DNA damage checkpoint|positive regulation of cytokinesis|peptidyl-tyrosine dephosphorylation|cilium assembly|mitotic cell cycle arrest|mitotic spindle|protein serine phosphatase activity|protein threonine phosphatase activity CDC16 1021.563323 999.7316288 1043.395017 1.043675109 0.061672678 0.863049195 1 21.45461024 23.35618384 8881 cell division cycle 16 "GO:0005515,GO:0005654,GO:0005680,GO:0005737,GO:0005813,GO:0005829,GO:0006511,GO:0007091,GO:0016567,GO:0031145,GO:0045842,GO:0051301,GO:0070979,GO:0072686,GO:1901990" protein binding|nucleoplasm|anaphase-promoting complex|cytoplasm|centrosome|cytosol|ubiquitin-dependent protein catabolic process|metaphase/anaphase transition of mitotic cell cycle|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|mitotic spindle|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC20 3727.236497 3905.550566 3548.922428 0.908686847 -0.138144899 0.664650728 1 119.9529158 113.6948991 991 cell division cycle 20 "GO:0000922,GO:0005515,GO:0005654,GO:0005680,GO:0005813,GO:0005819,GO:0005829,GO:0006511,GO:0007064,GO:0007094,GO:0007399,GO:0008022,GO:0008284,GO:0010997,GO:0016567,GO:0016579,GO:0019899,GO:0030154,GO:0031145,GO:0031915,GO:0040020,GO:0042826,GO:0048471,GO:0050773,GO:0051301,GO:0090129,GO:0090307,GO:1901990,GO:1904668,GO:1905786,GO:1990757" spindle pole|protein binding|nucleoplasm|anaphase-promoting complex|centrosome|spindle|cytosol|ubiquitin-dependent protein catabolic process|mitotic sister chromatid cohesion|mitotic spindle assembly checkpoint|nervous system development|protein C-terminus binding|positive regulation of cell population proliferation|anaphase-promoting complex binding|protein ubiquitination|protein deubiquitination|enzyme binding|cell differentiation|anaphase-promoting complex-dependent catabolic process|positive regulation of synaptic plasticity|regulation of meiotic nuclear division|histone deacetylase binding|perinuclear region of cytoplasm|regulation of dendrite development|cell division|positive regulation of synapse maturation|mitotic spindle assembly|regulation of mitotic cell cycle phase transition|positive regulation of ubiquitin protein ligase activity|positive regulation of anaphase-promoting complex-dependent catabolic process|ubiquitin ligase activator activity "hsa04110,hsa04114,hsa04120,hsa05166,hsa05203" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Human T-cell leukemia virus 1 infection|Viral carcinogenesis CDC20B 2.463161041 0 4.926322083 Inf Inf 0.189235799 1 0 0.0628771 166979 cell division cycle 20B "GO:0005515,GO:0005680,GO:0010997,GO:0031145,GO:1904668,GO:1905786,GO:1990757" protein binding|anaphase-promoting complex|anaphase-promoting complex binding|anaphase-promoting complex-dependent catabolic process|positive regulation of ubiquitin protein ligase activity|positive regulation of anaphase-promoting complex-dependent catabolic process|ubiquitin ligase activator activity CDC23 1153.164908 1071.793503 1234.536314 1.151841573 0.203942299 0.554286726 1 17.32606443 20.81654281 8697 cell division cycle 23 "GO:0000278,GO:0004842,GO:0005515,GO:0005654,GO:0005680,GO:0005737,GO:0005829,GO:0006511,GO:0007080,GO:0007091,GO:0007096,GO:0016567,GO:0030071,GO:0031145,GO:0045842,GO:0051301,GO:0070979,GO:1901990" mitotic cell cycle|ubiquitin-protein transferase activity|protein binding|nucleoplasm|anaphase-promoting complex|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|mitotic metaphase plate congression|metaphase/anaphase transition of mitotic cell cycle|regulation of exit from mitosis|protein ubiquitination|regulation of mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC25A 457.376965 486.1639089 428.5900212 0.881575151 -0.181844536 0.666422581 1 6.435568975 5.917826375 993 cell division cycle 25A "GO:0000079,GO:0000082,GO:0000086,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008283,GO:0009314,GO:0010971,GO:0016579,GO:0019901,GO:0034644,GO:0035335,GO:0051087,GO:0051301,GO:0051726,GO:0110032" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell population proliferation|response to radiation|positive regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|protein kinase binding|cellular response to UV|peptidyl-tyrosine dephosphorylation|chaperone binding|cell division|regulation of cell cycle|positive regulation of G2/MI transition of meiotic cell cycle "hsa04110,hsa04218,hsa04914,hsa05206" Cell cycle|Cellular senescence|Progesterone-mediated oocyte maturation|MicroRNAs in cancer CDC25B 6185.31188 6050.152527 6320.471232 1.044679651 0.063060611 0.846492523 1 84.20414451 91.75559018 994 cell division cycle 25B "GO:0000086,GO:0000278,GO:0000922,GO:0001556,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0007144,GO:0008284,GO:0010971,GO:0019901,GO:0032467,GO:0035335,GO:0045860,GO:0045931,GO:0051301,GO:0110032" G2/M transition of mitotic cell cycle|mitotic cell cycle|spindle pole|oocyte maturation|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|female meiosis I|positive regulation of cell population proliferation|positive regulation of G2/M transition of mitotic cell cycle|protein kinase binding|positive regulation of cytokinesis|peptidyl-tyrosine dephosphorylation|positive regulation of protein kinase activity|positive regulation of mitotic cell cycle|cell division|positive regulation of G2/MI transition of meiotic cell cycle "hsa04010,hsa04110,hsa04914,hsa05206" MAPK signaling pathway|Cell cycle|Progesterone-mediated oocyte maturation|MicroRNAs in cancer CDC25C 383.3918214 311.5914823 455.1921604 1.460862014 0.546819915 0.213181471 1 7.994432294 12.18183619 995 cell division cycle 25C "GO:0000079,GO:0000086,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005758,GO:0005829,GO:0006977,GO:0007088,GO:0007283,GO:0008283,GO:0010971,GO:0016032,GO:0016607,GO:0019901,GO:0035335,GO:0048471,GO:0050699,GO:0051301,GO:0110032" "regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial intermembrane space|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|regulation of mitotic nuclear division|spermatogenesis|cell population proliferation|positive regulation of G2/M transition of mitotic cell cycle|viral process|nuclear speck|protein kinase binding|peptidyl-tyrosine dephosphorylation|perinuclear region of cytoplasm|WW domain binding|cell division|positive regulation of G2/MI transition of meiotic cell cycle" "hsa04110,hsa04114,hsa04914,hsa05170,hsa05206" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection|MicroRNAs in cancer CDC26 337.2449757 356.2495449 318.2404065 0.893307546 -0.162771147 0.725402007 1 11.85465353 11.0460193 246184 cell division cycle 26 "GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0007346,GO:0030071,GO:0031145,GO:0051301,GO:0070979,GO:1901990" protein binding|nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|regulation of mitotic cell cycle|regulation of mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent catabolic process|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC27 2822.729366 2859.130963 2786.32777 0.974536601 -0.037211725 0.908001874 1 24.5723565 24.97818581 996 cell division cycle 27 "GO:0005515,GO:0005634,GO:0005654,GO:0005680,GO:0005737,GO:0005813,GO:0005819,GO:0005829,GO:0006511,GO:0007091,GO:0016567,GO:0019903,GO:0031145,GO:0045842,GO:0051301,GO:0070979,GO:0072686,GO:1901990" protein binding|nucleus|nucleoplasm|anaphase-promoting complex|cytoplasm|centrosome|spindle|cytosol|ubiquitin-dependent protein catabolic process|metaphase/anaphase transition of mitotic cell cycle|protein ubiquitination|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|mitotic spindle|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC34 1039.508645 980.4474654 1098.569824 1.120478009 0.164114335 0.640483085 1 27.37387283 31.99304026 997 "cell division cycle 34, ubiqiutin conjugating enzyme" "GO:0000082,GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006270,GO:0006464,GO:0006511,GO:0016567,GO:0016607,GO:0035458,GO:0043161,GO:0043525,GO:0043951,GO:0061631,GO:0070848,GO:0070936,GO:0090261" G1/S transition of mitotic cell cycle|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA replication initiation|cellular protein modification process|ubiquitin-dependent protein catabolic process|protein ubiquitination|nuclear speck|cellular response to interferon-beta|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of neuron apoptotic process|negative regulation of cAMP-mediated signaling|ubiquitin conjugating enzyme activity|response to growth factor|protein K48-linked ubiquitination|positive regulation of inclusion body assembly hsa04120 Ubiquitin mediated proteolysis CDC37 3911.773653 4161.31947 3662.227836 0.880064091 -0.184319503 0.563069814 1 129.8559155 119.204313 11140 "cell division cycle 37, HSP90 cochaperone" "GO:0000079,GO:0005515,GO:0005737,GO:0005829,GO:0006457,GO:0006605,GO:0010608,GO:0019887,GO:0019900,GO:0019901,GO:0031072,GO:0038128,GO:0050821,GO:0051082,GO:0051087,GO:0051879,GO:0060334,GO:0060338,GO:0070062,GO:0097110,GO:0098779,GO:0101031,GO:1990565" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|cytoplasm|cytosol|protein folding|protein targeting|posttranscriptional regulation of gene expression|protein kinase regulator activity|kinase binding|protein kinase binding|heat shock protein binding|ERBB2 signaling pathway|protein stabilization|unfolded protein binding|chaperone binding|Hsp90 protein binding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|extracellular exosome|scaffold protein binding|positive regulation of mitophagy in response to mitochondrial depolarization|chaperone complex|HSP90-CDC37 chaperone complex hsa04151 PI3K-Akt signaling pathway CDC37L1 131.2074303 146.1536594 116.2612012 0.795472393 -0.330116233 0.599386271 1 2.114904929 1.754817234 55664 cell division cycle 37 like 1 "GO:0002576,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006457,GO:0031072,GO:0031089,GO:0050821,GO:0051082,GO:0051087" platelet degranulation|protein binding|extracellular region|cytoplasm|cytosol|protein folding|heat shock protein binding|platelet dense granule lumen|protein stabilization|unfolded protein binding|chaperone binding CDC40 434.1220524 445.5656701 422.6784347 0.948633306 -0.076077573 0.86249712 1 5.84771426 5.78629327 51362 cell division cycle 40 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0006405,GO:0006406,GO:0016607,GO:0031124,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|nuclear speck|mRNA 3'-end processing|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome CDC42 4662.245256 4544.972826 4779.517685 1.051605338 0.07259337 0.821095677 1 20.02669566 21.9673672 998 cell division cycle 42 "GO:0000139,GO:0000322,GO:0002040,GO:0003161,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005789,GO:0005813,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0006897,GO:0006911,GO:0007015,GO:0007030,GO:0007088,GO:0007097,GO:0007163,GO:0007229,GO:0007596,GO:0010591,GO:0010592,GO:0016020,GO:0016477,GO:0016567,GO:0017119,GO:0019901,GO:0021762,GO:0030031,GO:0030036,GO:0030141,GO:0030175,GO:0030225,GO:0030307,GO:0030496,GO:0030742,GO:0031256,GO:0031274,GO:0031295,GO:0031333,GO:0031435,GO:0031996,GO:0032427,GO:0032467,GO:0032488,GO:0032991,GO:0034191,GO:0034329,GO:0034332,GO:0034613,GO:0035722,GO:0036336,GO:0036464,GO:0038096,GO:0038189,GO:0039694,GO:0042059,GO:0042802,GO:0043005,GO:0043025,GO:0043197,GO:0043393,GO:0043525,GO:0043552,GO:0045177,GO:0045198,GO:0045335,GO:0045740,GO:0046330,GO:0046847,GO:0048010,GO:0048013,GO:0048549,GO:0048664,GO:0051056,GO:0051149,GO:0051233,GO:0051489,GO:0051491,GO:0051492,GO:0051496,GO:0051683,GO:0051835,GO:0051988,GO:0060047,GO:0060071,GO:0060501,GO:0060661,GO:0060997,GO:0061630,GO:0070062,GO:0071346,GO:0072384,GO:0072686,GO:0090135,GO:0090316,GO:0098685,GO:0099159,GO:0099563,GO:1900026,GO:2000251" "Golgi membrane|storage vacuole|sprouting angiogenesis|cardiac conduction system development|GTPase activity|protein binding|GTP binding|cytoplasm|endoplasmic reticulum membrane|centrosome|cytosol|plasma membrane|cell-cell junction|focal adhesion|endocytosis|phagocytosis, engulfment|actin filament organization|Golgi organization|regulation of mitotic nuclear division|nuclear migration|establishment or maintenance of cell polarity|integrin-mediated signaling pathway|blood coagulation|regulation of lamellipodium assembly|positive regulation of lamellipodium assembly|membrane|cell migration|protein ubiquitination|Golgi transport complex|protein kinase binding|substantia nigra development|cell projection assembly|actin cytoskeleton organization|secretory granule|filopodium|macrophage differentiation|positive regulation of cell growth|midbody|GTP-dependent protein binding|leading edge membrane|positive regulation of pseudopodium assembly|T cell costimulation|negative regulation of protein-containing complex assembly|mitogen-activated protein kinase kinase kinase binding|thioesterase binding|GBD domain binding|positive regulation of cytokinesis|Cdc42 protein signal transduction|protein-containing complex|apolipoprotein A-I receptor binding|cell junction assembly|adherens junction organization|cellular protein localization|interleukin-12-mediated signaling pathway|dendritic cell migration|cytoplasmic ribonucleoprotein granule|Fc-gamma receptor signaling pathway involved in phagocytosis|neuropilin signaling pathway|viral RNA genome replication|negative regulation of epidermal growth factor receptor signaling pathway|identical protein binding|neuron projection|neuronal cell body|dendritic spine|regulation of protein binding|positive regulation of neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|apical part of cell|establishment of epithelial cell apical/basal polarity|phagocytic vesicle|positive regulation of DNA replication|positive regulation of JNK cascade|filopodium assembly|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|positive regulation of pinocytosis|neuron fate determination|regulation of small GTPase mediated signal transduction|positive regulation of muscle cell differentiation|spindle midzone|regulation of filopodium assembly|positive regulation of filopodium assembly|regulation of stress fiber assembly|positive regulation of stress fiber assembly|establishment of Golgi localization|positive regulation of synapse structural plasticity|regulation of attachment of spindle microtubules to kinetochore|heart contraction|Wnt signaling pathway, planar cell polarity pathway|positive regulation of epithelial cell proliferation involved in lung morphogenesis|submandibular salivary gland formation|dendritic spine morphogenesis|ubiquitin protein ligase activity|extracellular exosome|cellular response to interferon-gamma|organelle transport along microtubule|mitotic spindle|actin filament branching|positive regulation of intracellular protein transport|Schaffer collateral - CA1 synapse|regulation of modification of postsynaptic structure|modification of synaptic structure|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of actin cytoskeleton reorganization" "hsa04010,hsa04014,hsa04015,hsa04062,hsa04144,hsa04360,hsa04370,hsa04510,hsa04520,hsa04530,hsa04660,hsa04666,hsa04670,hsa04722,hsa04810,hsa04912,hsa04932,hsa04933,hsa05100,hsa05120,hsa05130,hsa05131,hsa05132,hsa05135,hsa05165,hsa05200,hsa05203,hsa05205,hsa05211,hsa05212" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Endocytosis|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Tight junction|T cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|GnRH signaling pathway|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Human papillomavirus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Renal cell carcinoma|Pancreatic cancer CDC42BPA 3091.963136 2640.91543 3543.010842 1.341584362 0.423937778 0.182942126 1 11.65502352 16.30974126 8476 CDC42 binding protein kinase alpha "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005856,GO:0005911,GO:0006468,GO:0016477,GO:0018107,GO:0030027,GO:0031032,GO:0031252,GO:0031532,GO:0035556,GO:0042641,GO:0042802,GO:0070062,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytoskeleton|cell-cell junction|protein phosphorylation|cell migration|peptidyl-threonine phosphorylation|lamellipodium|actomyosin structure organization|cell leading edge|actin cytoskeleton reorganization|intracellular signal transduction|actomyosin|identical protein binding|extracellular exosome|protein serine kinase activity|protein threonine kinase activity CDC42BPB 4734.304654 4352.131192 5116.478115 1.175625892 0.233429038 0.466309401 1 31.37205971 38.47052429 9578 CDC42 binding protein kinase beta "GO:0000287,GO:0004672,GO:0004674,GO:0005524,GO:0005737,GO:0005856,GO:0005886,GO:0005911,GO:0006468,GO:0007010,GO:0007163,GO:0007165,GO:0016477,GO:0018107,GO:0030027,GO:0031032,GO:0031252,GO:0031532,GO:0035556,GO:0042641,GO:0044877,GO:0070062,GO:0106310,GO:0106311" magnesium ion binding|protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytoskeleton|plasma membrane|cell-cell junction|protein phosphorylation|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction|cell migration|peptidyl-threonine phosphorylation|lamellipodium|actomyosin structure organization|cell leading edge|actin cytoskeleton reorganization|intracellular signal transduction|actomyosin|protein-containing complex binding|extracellular exosome|protein serine kinase activity|protein threonine kinase activity CDC42BPG 62.15528969 73.07682972 51.23374966 0.701094312 -0.512319565 0.524158299 1 0.568784943 0.415949364 55561 CDC42 binding protein kinase gamma "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0018107,GO:0031032,GO:0031252,GO:0031532,GO:0034451,GO:0035556,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|peptidyl-threonine phosphorylation|actomyosin structure organization|cell leading edge|actin cytoskeleton reorganization|centriolar satellite|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity CDC42EP1 1195.05473 1241.291149 1148.81831 0.9255027 -0.111690897 0.745771843 1 29.26769912 28.25414706 11135 CDC42 effector protein 1 "GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0007266,GO:0008360,GO:0012505,GO:0030838,GO:0031274,GO:0098609,GO:0098641" protein binding|cytoplasm|cytoskeleton|plasma membrane|adherens junction|focal adhesion|Rho protein signal transduction|regulation of cell shape|endomembrane system|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|cell-cell adhesion|cadherin binding involved in cell-cell adhesion CDC42EP2 822.3226674 917.5201954 727.1251394 0.79248952 -0.335536238 0.358731629 1 23.6725222 19.5683402 10435 CDC42 effector protein 2 "GO:0001515,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0007015,GO:0007266,GO:0008360,GO:0012505,GO:0015630,GO:0016020,GO:0030036,GO:0030838,GO:0031267,GO:0031274,GO:0031334,GO:0043547,GO:0045335,GO:0071346" opioid peptide activity|GTPase activator activity|protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|actin filament organization|Rho protein signal transduction|regulation of cell shape|endomembrane system|microtubule cytoskeleton|membrane|actin cytoskeleton organization|positive regulation of actin filament polymerization|small GTPase binding|positive regulation of pseudopodium assembly|positive regulation of protein-containing complex assembly|positive regulation of GTPase activity|phagocytic vesicle|cellular response to interferon-gamma CDC42EP3 796.9178389 696.2597943 897.5758835 1.289139328 0.366408196 0.319209265 1 5.820914877 7.827210901 10602 CDC42 effector protein 3 "GO:0005515,GO:0005519,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0007165,GO:0007266,GO:0008360,GO:0012505,GO:0015629,GO:0030838,GO:0031274" protein binding|cytoskeletal regulatory protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|signal transduction|Rho protein signal transduction|regulation of cell shape|endomembrane system|actin cytoskeleton|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly CDC42EP4 1104.077115 1117.466521 1090.687709 0.976036139 -0.034993528 0.922202145 1 16.05552826 16.34580928 23580 CDC42 effector protein 4 "GO:0003723,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0005912,GO:0007266,GO:0008360,GO:0012505,GO:0015629,GO:0015630,GO:0030838,GO:0031267,GO:0031274,GO:0045335,GO:0071346" RNA binding|protein binding|cytoplasm|cytoskeleton|plasma membrane|adherens junction|Rho protein signal transduction|regulation of cell shape|endomembrane system|actin cytoskeleton|microtubule cytoskeleton|positive regulation of actin filament polymerization|small GTPase binding|positive regulation of pseudopodium assembly|phagocytic vesicle|cellular response to interferon-gamma CDC42EP5 6.045198483 9.134603715 2.95579325 0.32358199 -1.627796782 0.370626867 1 0.516334211 0.174273428 148170 CDC42 effector protein 5 "GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0007254,GO:0007266,GO:0008360,GO:0012505,GO:0016020,GO:0030838,GO:0031267,GO:0031274" cytoplasm|cytosol|cytoskeleton|plasma membrane|JNK cascade|Rho protein signal transduction|regulation of cell shape|endomembrane system|membrane|positive regulation of actin filament polymerization|small GTPase binding|positive regulation of pseudopodium assembly CDC42SE1 3198.409057 3283.382558 3113.435556 0.948240268 -0.076675435 0.810200632 1 52.84135477 52.26467662 56882 CDC42 small effector 1 "GO:0005095,GO:0005737,GO:0005856,GO:0005886,GO:0006909,GO:0007165,GO:0008360,GO:0030054,GO:0034260,GO:0035023" GTPase inhibitor activity|cytoplasm|cytoskeleton|plasma membrane|phagocytosis|signal transduction|regulation of cell shape|cell junction|negative regulation of GTPase activity|regulation of Rho protein signal transduction CDC42SE2 831.4830033 802.830171 860.1358356 1.07137956 0.099469678 0.787462399 1 11.03705645 12.33424441 56990 CDC42 small effector 2 "GO:0001891,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0006909,GO:0008360,GO:0009966,GO:0035023,GO:0035591,GO:0042995" phagocytic cup|protein binding|cytoplasm|cytoskeleton|plasma membrane|phagocytosis|regulation of cell shape|regulation of signal transduction|regulation of Rho protein signal transduction|signaling adaptor activity|cell projection CDC45 1067.614413 847.4882336 1287.740592 1.519479022 0.603576757 0.083733934 1 17.78056722 28.18099025 8318 cell division cycle 45 "GO:0000076,GO:0000082,GO:0000083,GO:0000727,GO:0003682,GO:0003688,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006260,GO:0006270,GO:0031261,GO:0031938,GO:0036064,GO:1902977" DNA replication checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromatin binding|DNA replication origin binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|DNA replication|DNA replication initiation|DNA replication preinitiation complex|regulation of chromatin silencing at telomere|ciliary basal body|mitotic DNA replication preinitiation complex assembly hsa04110 Cell cycle CDC5L 1216.389094 1217.947162 1214.831026 0.997441485 -0.003695887 0.994107081 1 9.883788992 10.28316541 988 cell division cycle 5 like "GO:0000278,GO:0000398,GO:0000974,GO:0000977,GO:0000981,GO:0001222,GO:0001228,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0005681,GO:0005737,GO:0006281,GO:0006357,GO:0008157,GO:0016020,GO:0016607,GO:0019901,GO:0043522,GO:0044344,GO:0045944,GO:0048471,GO:0071007,GO:0071013,GO:0071352,GO:0071987,GO:0072422,GO:1904568,GO:1990090,GO:1990646" "mitotic cell cycle|mRNA splicing, via spliceosome|Prp19 complex|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription corepressor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|spliceosomal complex|cytoplasm|DNA repair|regulation of transcription by RNA polymerase II|protein phosphatase 1 binding|membrane|nuclear speck|protein kinase binding|leucine zipper domain binding|cellular response to fibroblast growth factor stimulus|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|cellular response to interleukin-2|WD40-repeat domain binding|signal transduction involved in DNA damage checkpoint|cellular response to wortmannin|cellular response to nerve growth factor stimulus|cellular response to prolactin" hsa03040 Spliceosome CDC6 1610.705177 1569.121927 1652.288427 1.053001936 0.074508088 0.82219984 1 26.58765141 29.20283909 990 cell division cycle 6 "GO:0000076,GO:0000079,GO:0000082,GO:0000083,GO:0000166,GO:0000278,GO:0000922,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006260,GO:0006270,GO:0007089,GO:0008156,GO:0008285,GO:0019900,GO:0030071,GO:0032467,GO:0033314,GO:0045171,GO:0045737,GO:0048146,GO:0051233,GO:0051301,GO:0051984,GO:0072686,GO:1904117,GO:1904385" DNA replication checkpoint|regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|nucleotide binding|mitotic cell cycle|spindle pole|DNA replication origin binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|DNA replication|DNA replication initiation|traversing start control point of mitotic cell cycle|negative regulation of DNA replication|negative regulation of cell population proliferation|kinase binding|regulation of mitotic metaphase/anaphase transition|positive regulation of cytokinesis|mitotic DNA replication checkpoint|intercellular bridge|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of fibroblast proliferation|spindle midzone|cell division|positive regulation of chromosome segregation|mitotic spindle|cellular response to vasopressin|cellular response to angiotensin hsa04110 Cell cycle CDC7 822.606221 734.8281211 910.3843209 1.238907841 0.309068873 0.398021782 1 10.69438276 13.82008312 8317 cell division cycle 7 "GO:0000082,GO:0000727,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0008284,GO:0010571,GO:0010971,GO:0016301,GO:0018105,GO:0044770,GO:0045171,GO:0046872,GO:0051301,GO:0070317,GO:0072686,GO:0106310,GO:0106311" G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|DNA replication|positive regulation of cell population proliferation|positive regulation of nuclear cell cycle DNA replication|positive regulation of G2/M transition of mitotic cell cycle|kinase activity|peptidyl-serine phosphorylation|cell cycle phase transition|intercellular bridge|metal ion binding|cell division|negative regulation of G0 to G1 transition|mitotic spindle|protein serine kinase activity|protein threonine kinase activity hsa04110 Cell cycle CDC73 1486.318885 1619.869726 1352.768044 0.835109159 -0.259963307 0.433768626 1 13.4426818 11.70968184 79577 cell division cycle 73 "GO:0000122,GO:0000781,GO:0000993,GO:0001558,GO:0001711,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006366,GO:0006368,GO:0006378,GO:0007049,GO:0008285,GO:0010390,GO:0016055,GO:0016567,GO:0016593,GO:0019827,GO:0030177,GO:0031442,GO:0031648,GO:0032968,GO:0033523,GO:0034402,GO:0043066,GO:0045638,GO:0048147,GO:0050680,GO:0071222,GO:1902808,GO:1904837,GO:2000134" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|RNA polymerase II complex binding|regulation of cell growth|endodermal cell fate commitment|protein binding|nucleus|nucleoplasm|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA polyadenylation|cell cycle|negative regulation of cell population proliferation|histone monoubiquitination|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|stem cell population maintenance|positive regulation of Wnt signaling pathway|positive regulation of mRNA 3'-end processing|protein destabilization|positive regulation of transcription elongation from RNA polymerase II promoter|histone H2B ubiquitination|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|negative regulation of apoptotic process|negative regulation of myeloid cell differentiation|negative regulation of fibroblast proliferation|negative regulation of epithelial cell proliferation|cellular response to lipopolysaccharide|positive regulation of cell cycle G1/S phase transition|beta-catenin-TCF complex assembly|negative regulation of G1/S transition of mitotic cell cycle" CDCA2 658.9862638 629.2727004 688.6998272 1.094437796 0.130189959 0.736361166 1 7.579177725 8.652250875 157313 cell division cycle associated 2 "GO:0005654,GO:0005694,GO:0005829,GO:0007049,GO:0007059,GO:0035307,GO:0051301" nucleoplasm|chromosome|cytosol|cell cycle|chromosome segregation|positive regulation of protein dephosphorylation|cell division CDCA3 1013.077974 891.1313402 1135.024608 1.273689474 0.349013591 0.321079463 1 13.8869719 18.44960387 83461 cell division cycle associated 3 "GO:0005515,GO:0005829,GO:0005912,GO:0007049,GO:0008150,GO:0016567,GO:0051301" protein binding|cytosol|adherens junction|cell cycle|biological_process|protein ubiquitination|cell division CDCA4 1939.879248 1676.70726 2203.051235 1.313915248 0.39387222 0.222841964 1 34.68925966 47.54209479 55038 cell division cycle associated 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0048096,GO:0140110" protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|chromatin-mediated maintenance of transcription|transcription regulator activity CDCA5 2224.284408 1956.835107 2491.733709 1.273348838 0.348627704 0.276499346 1 27.09316426 35.98512835 113130 cell division cycle associated 5 "GO:0000278,GO:0000775,GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006302,GO:0007064,GO:0007076,GO:0007080,GO:0031536,GO:0044877,GO:0051301,GO:0071922" "mitotic cell cycle|chromosome, centromeric region|chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|double-strand break repair|mitotic sister chromatid cohesion|mitotic chromosome condensation|mitotic metaphase plate congression|positive regulation of exit from mitosis|protein-containing complex binding|cell division|regulation of cohesin loading" hsa05206 MicroRNAs in cancer CDCA7 548.3991167 613.0334049 483.7648285 0.7891329 -0.341659806 0.392904522 1 11.17637844 9.199562592 83879 cell division cycle associated 7 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006915,GO:0042127" "protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|apoptotic process|regulation of cell population proliferation" CDCA7L 778.1141835 623.1829646 933.0454025 1.497225463 0.582291489 0.115342978 1 10.74634617 16.78278227 55536 cell division cycle associated 7 like "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006355,GO:0008284" "fibrillar center|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription, DNA-templated|positive regulation of cell population proliferation" CDCA8 1265.394493 1267.680004 1263.108982 0.996394183 -0.005211496 0.990385094 1 28.23373796 29.34374181 55143 cell division cycle associated 8 "GO:0000070,GO:0000775,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0007080,GO:0010369,GO:0030496,GO:0032133,GO:0032991,GO:0045171,GO:0051233,GO:0051276,GO:0051301" "mitotic sister chromatid segregation|chromosome, centromeric region|protein binding|nucleoplasm|nucleolus|cytosol|mitotic metaphase plate congression|chromocenter|midbody|chromosome passenger complex|protein-containing complex|intercellular bridge|spindle midzone|chromosome organization|cell division" CDCP1 22370.72583 25919.94552 18821.50615 0.726139881 -0.461680605 0.212730393 1 210.4784032 159.4203505 64866 CUB domain containing protein 1 "GO:0005515,GO:0005576,GO:0005886,GO:0016021" protein binding|extracellular region|plasma membrane|integral component of membrane CDH10 9.986256149 9.134603715 10.83790858 1.186467297 0.246672336 0.934370347 1 0.133055926 0.164666753 1008 cadherin 10 "GO:0000902,GO:0005509,GO:0005886,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0098609,GO:0098742,GO:0098978,GO:0098982,GO:0099059,GO:0099060" cell morphogenesis|calcium ion binding|plasma membrane|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules|glutamatergic synapse|GABA-ergic synapse|integral component of presynaptic active zone membrane|integral component of postsynaptic specialization membrane CDH11 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.013649479 0.020731411 1009 cadherin 11 "GO:0000902,GO:0001501,GO:0001503,GO:0005509,GO:0005737,GO:0005886,GO:0005912,GO:0007043,GO:0007155,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0021957,GO:0034332,GO:0045296,GO:0050804,GO:0070062,GO:0098685,GO:0098742,GO:0098978" cell morphogenesis|skeletal system development|ossification|calcium ion binding|cytoplasm|plasma membrane|adherens junction|cell-cell junction assembly|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|corticospinal tract morphogenesis|adherens junction organization|cadherin binding|modulation of chemical synaptic transmission|extracellular exosome|Schaffer collateral - CA1 synapse|cell-cell adhesion via plasma-membrane adhesion molecules|glutamatergic synapse CDH13 1281.332914 1144.870332 1417.795495 1.238389585 0.308465243 0.362644328 1 13.24129789 17.1042398 1012 cadherin 13 "GO:0000278,GO:0001938,GO:0001954,GO:0002040,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0005901,GO:0005925,GO:0007156,GO:0007162,GO:0007266,GO:0008285,GO:0009897,GO:0016339,GO:0016342,GO:0016601,GO:0030032,GO:0030100,GO:0030169,GO:0030335,GO:0031225,GO:0034332,GO:0042058,GO:0042803,GO:0043005,GO:0043542,GO:0043616,GO:0045296,GO:0045944,GO:0048471,GO:0048661,GO:0050850,GO:0050927,GO:0051668,GO:0055096,GO:0055100,GO:0062023,GO:0070062,GO:0071813,GO:0098742,GO:0098982" mitotic cell cycle|positive regulation of endothelial cell proliferation|positive regulation of cell-matrix adhesion|sprouting angiogenesis|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|plasma membrane|caveola|focal adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of cell adhesion|Rho protein signal transduction|negative regulation of cell population proliferation|external side of plasma membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|Rac protein signal transduction|lamellipodium assembly|regulation of endocytosis|low-density lipoprotein particle binding|positive regulation of cell migration|anchored component of membrane|adherens junction organization|regulation of epidermal growth factor receptor signaling pathway|protein homodimerization activity|neuron projection|endothelial cell migration|keratinocyte proliferation|cadherin binding|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of positive chemotaxis|localization within membrane|low-density lipoprotein particle mediated signaling|adiponectin binding|collagen-containing extracellular matrix|extracellular exosome|lipoprotein particle binding|cell-cell adhesion via plasma-membrane adhesion molecules|GABA-ergic synapse CDH15 8.060264643 12.17947162 3.941057666 0.32358199 -1.627796782 0.302513 1 0.215229334 0.072644332 1013 cadherin 15 "GO:0005509,GO:0005515,GO:0005794,GO:0005886,GO:0005901,GO:0007155,GO:0007156,GO:0016021,GO:0016342,GO:0031594,GO:0034332,GO:0045296,GO:0051149,GO:0070062,GO:0098742" calcium ion binding|protein binding|Golgi apparatus|plasma membrane|caveola|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|catenin complex|neuromuscular junction|adherens junction organization|cadherin binding|positive regulation of muscle cell differentiation|extracellular exosome|cell-cell adhesion via plasma-membrane adhesion molecules hsa04514 Cell adhesion molecules CDH18 9.090066388 15.22433953 2.95579325 0.194149194 -2.364762376 0.124048809 1 0.096903241 0.019624103 1016 cadherin 18 "GO:0000902,GO:0005509,GO:0005886,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0098742" cell morphogenesis|calcium ion binding|plasma membrane|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|cell-cell adhesion via plasma-membrane adhesion molecules CDH2 4252.129561 4629.214172 3875.04495 0.837084828 -0.256554265 0.42164481 1 51.14602245 44.65779393 1000 cadherin 2 "GO:0003323,GO:0005509,GO:0005515,GO:0005737,GO:0005788,GO:0005886,GO:0005887,GO:0005911,GO:0005912,GO:0005916,GO:0005925,GO:0007043,GO:0007155,GO:0007156,GO:0007157,GO:0007416,GO:0007420,GO:0008013,GO:0009986,GO:0010001,GO:0014032,GO:0014069,GO:0014704,GO:0016323,GO:0016324,GO:0016327,GO:0016339,GO:0016342,GO:0019901,GO:0019903,GO:0021987,GO:0030027,GO:0030054,GO:0030864,GO:0034332,GO:0035995,GO:0042383,GO:0042802,GO:0043005,GO:0043410,GO:0043687,GO:0044267,GO:0044331,GO:0044853,GO:0045177,GO:0045294,GO:0045295,GO:0045296,GO:0048514,GO:0048854,GO:0048872,GO:0050770,GO:0051146,GO:0051149,GO:0051966,GO:0060019,GO:0060563,GO:0062023,GO:0070445,GO:0072659,GO:0090090,GO:0090497,GO:0097118,GO:0097150,GO:0098609,GO:0098742,GO:0099059,GO:0099060,GO:1902897,GO:2000809" "type B pancreatic cell development|calcium ion binding|protein binding|cytoplasm|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|cell-cell junction|adherens junction|fascia adherens|focal adhesion|cell-cell junction assembly|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|synapse assembly|brain development|beta-catenin binding|cell surface|glial cell differentiation|neural crest cell development|postsynaptic density|intercalated disc|basolateral plasma membrane|apical plasma membrane|apicolateral plasma membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|protein kinase binding|protein phosphatase binding|cerebral cortex development|lamellipodium|cell junction|cortical actin cytoskeleton|adherens junction organization|detection of muscle stretch|sarcolemma|identical protein binding|neuron projection|positive regulation of MAPK cascade|post-translational protein modification|cellular protein metabolic process|cell-cell adhesion mediated by cadherin|plasma membrane raft|apical part of cell|alpha-catenin binding|gamma-catenin binding|cadherin binding|blood vessel morphogenesis|brain morphogenesis|homeostasis of number of cells|regulation of axonogenesis|striated muscle cell differentiation|positive regulation of muscle cell differentiation|regulation of synaptic transmission, glutamatergic|radial glial cell differentiation|neuroepithelial cell differentiation|collagen-containing extracellular matrix|regulation of oligodendrocyte progenitor proliferation|protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway|mesenchymal cell migration|neuroligin clustering involved in postsynaptic membrane assembly|neuronal stem cell population maintenance|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules|integral component of presynaptic active zone membrane|integral component of postsynaptic specialization membrane|regulation of postsynaptic density protein 95 clustering|positive regulation of synaptic vesicle clustering" "hsa04514,hsa05412" Cell adhesion molecules|Arrhythmogenic right ventricular cardiomyopathy CDH24 501.7111422 519.6574558 483.7648285 0.930930218 -0.103255067 0.804216264 1 5.136381127 4.987584871 64403 cadherin 24 "GO:0000902,GO:0005509,GO:0005886,GO:0005911,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0098609,GO:0098742" cell morphogenesis|calcium ion binding|plasma membrane|cell-cell junction|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules CDH26 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.009837133 0.014941057 60437 cadherin 26 "GO:0005178,GO:0005509,GO:0005515,GO:0005886,GO:0007156,GO:0008013,GO:0015630,GO:0016021,GO:0016342,GO:0035710,GO:0045294,GO:0045296,GO:0070097,GO:0098742" "integrin binding|calcium ion binding|protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|beta-catenin binding|microtubule cytoskeleton|integral component of membrane|catenin complex|CD4-positive, alpha-beta T cell activation|alpha-catenin binding|cadherin binding|delta-catenin binding|cell-cell adhesion via plasma-membrane adhesion molecules" CDH3 37.06618183 8.119647747 66.01271591 8.129997503 3.023254909 0.00302269 0.187933644 0.073975808 0.62733 1001 cadherin 3 "GO:0001895,GO:0003674,GO:0005509,GO:0005737,GO:0005886,GO:0005912,GO:0007155,GO:0007156,GO:0007601,GO:0010628,GO:0010838,GO:0016021,GO:0016342,GO:0022405,GO:0030054,GO:0031424,GO:0032773,GO:0032912,GO:0034332,GO:0042060,GO:0042493,GO:0043568,GO:0045296,GO:0048023,GO:0051796,GO:0060901,GO:0090263,GO:0098742,GO:1902910" retina homeostasis|molecular_function|calcium ion binding|cytoplasm|plasma membrane|adherens junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|visual perception|positive regulation of gene expression|positive regulation of keratinocyte proliferation|integral component of membrane|catenin complex|hair cycle process|cell junction|keratinization|positive regulation of monophenol monooxygenase activity|negative regulation of transforming growth factor beta2 production|adherens junction organization|wound healing|response to drug|positive regulation of insulin-like growth factor receptor signaling pathway|cadherin binding|positive regulation of melanin biosynthetic process|negative regulation of timing of catagen|regulation of hair cycle by canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|cell-cell adhesion via plasma-membrane adhesion molecules|positive regulation of melanosome transport hsa04514 Cell adhesion molecules CDH4 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.029462066 0 1002 cadherin 4 "GO:0005509,GO:0005886,GO:0005887,GO:0007155,GO:0007156,GO:0007157,GO:0007411,GO:0016342,GO:0034332,GO:0045296,GO:0045773,GO:0098742" calcium ion binding|plasma membrane|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axon guidance|catenin complex|adherens junction organization|cadherin binding|positive regulation of axon extension|cell-cell adhesion via plasma-membrane adhesion molecules hsa04514 Cell adhesion molecules CDH5 23.26975839 41.6131947 4.926322083 0.118383655 -3.078458191 0.008744349 0.39115812 0.511544056 0.063167068 1003 cadherin 5 "GO:0000902,GO:0001932,GO:0001944,GO:0001955,GO:0005102,GO:0005509,GO:0005515,GO:0005654,GO:0005886,GO:0005911,GO:0005912,GO:0005923,GO:0006874,GO:0007043,GO:0007156,GO:0007179,GO:0007275,GO:0008013,GO:0008285,GO:0009897,GO:0009986,GO:0010628,GO:0016020,GO:0016021,GO:0016339,GO:0016342,GO:0019903,GO:0030054,GO:0030335,GO:0030513,GO:0031115,GO:0031334,GO:0031965,GO:0034332,GO:0035307,GO:0035633,GO:0043114,GO:0043184,GO:0043534,GO:0044325,GO:0044331,GO:0045296,GO:0045766,GO:0050728,GO:0070051,GO:0070700,GO:0070830,GO:0098609,GO:0098742,GO:1902396,GO:1903142,GO:1990782,GO:2000114,GO:2000352" cell morphogenesis|regulation of protein phosphorylation|vasculature development|blood vessel maturation|signaling receptor binding|calcium ion binding|protein binding|nucleoplasm|plasma membrane|cell-cell junction|adherens junction|bicellular tight junction|cellular calcium ion homeostasis|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|transforming growth factor beta receptor signaling pathway|multicellular organism development|beta-catenin binding|negative regulation of cell population proliferation|external side of plasma membrane|cell surface|positive regulation of gene expression|membrane|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|protein phosphatase binding|cell junction|positive regulation of cell migration|positive regulation of BMP signaling pathway|negative regulation of microtubule polymerization|positive regulation of protein-containing complex assembly|nuclear membrane|adherens junction organization|positive regulation of protein dephosphorylation|maintenance of blood-brain barrier|regulation of vascular permeability|vascular endothelial growth factor receptor 2 binding|blood vessel endothelial cell migration|ion channel binding|cell-cell adhesion mediated by cadherin|cadherin binding|positive regulation of angiogenesis|negative regulation of inflammatory response|fibrinogen binding|BMP receptor binding|bicellular tight junction assembly|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules|protein localization to bicellular tight junction|positive regulation of establishment of endothelial barrier|protein tyrosine kinase binding|regulation of establishment of cell polarity|negative regulation of endothelial cell apoptotic process "hsa04514,hsa04670,hsa05418" Cell adhesion molecules|Leukocyte transendothelial migration|Fluid shear stress and atherosclerosis CDH6 15.67243441 27.40381115 3.941057666 0.143814218 -2.797721783 0.031557395 0.795035182 0.294047958 0.044109884 1004 cadherin 6 "GO:0000902,GO:0005509,GO:0005654,GO:0005886,GO:0005912,GO:0007043,GO:0007155,GO:0007156,GO:0007219,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0030054,GO:0034332,GO:0045296,GO:0098742" cell morphogenesis|calcium ion binding|nucleoplasm|plasma membrane|adherens junction|cell-cell junction assembly|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|Notch signaling pathway|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|cell junction|adherens junction organization|cadherin binding|cell-cell adhesion via plasma-membrane adhesion molecules CDHR1 12.36034253 3.044867905 21.67581716 7.118803784 2.831634837 0.046336987 0.975235287 0.019353893 0.143711421 92211 cadherin related family member 1 "GO:0003674,GO:0005509,GO:0005575,GO:0005887,GO:0007155,GO:0007156,GO:0008594,GO:0035845,GO:0042622,GO:0045494" molecular_function|calcium ion binding|cellular_component|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|photoreceptor cell morphogenesis|photoreceptor cell outer segment organization|photoreceptor outer segment membrane|photoreceptor cell maintenance CDHR3 16.58346994 22.3290313 10.83790858 0.485372985 -1.042834281 0.38652772 1 0.083626907 0.042338704 222256 cadherin related family member 3 "GO:0000902,GO:0001618,GO:0005509,GO:0005515,GO:0005886,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0046718,GO:0098742" cell morphogenesis|virus receptor activity|calcium ion binding|protein binding|plasma membrane|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|viral entry into host cell|cell-cell adhesion via plasma-membrane adhesion molecules CDIN1 182.0052093 183.7070303 180.3033882 0.981472445 -0.02698033 0.972194908 1 2.448450791 2.506602226 84529 CDAN1 interacting nuclease 1 "GO:0005515,GO:0005634,GO:0005737,GO:0030218" protein binding|nucleus|cytoplasm|erythrocyte differentiation CDIP1 313.7079934 296.3671428 331.048844 1.117022761 0.159658583 0.736709773 1 5.339719054 6.221517967 29965 cell death inducing p53 target 1 "GO:0003674,GO:0005515,GO:0005634,GO:0006915,GO:0033209,GO:0042771,GO:0046872,GO:0098560,GO:0098574" molecular_function|protein binding|nucleus|apoptotic process|tumor necrosis factor-mediated signaling pathway|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|metal ion binding|cytoplasmic side of late endosome membrane|cytoplasmic side of lysosomal membrane CDIPT 1172.635386 1022.06066 1323.210111 1.294649293 0.37256134 0.277933445 1 22.13072545 29.88571969 10423 CDP-diacylglycerol--inositol 3-phosphatidyltransferase "GO:0003881,GO:0005515,GO:0005789,GO:0005794,GO:0005886,GO:0006661,GO:0016020,GO:0016021" CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|phosphatidylinositol biosynthetic process|membrane|integral component of membrane "hsa00562,hsa00564,hsa04070" Inositol phosphate metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system CDK1 2666.082219 2186.215156 3145.949282 1.438993447 0.525060022 0.099870203 1 32.50853938 48.79464951 983 cyclin dependent kinase 1 "GO:0000086,GO:0000187,GO:0000226,GO:0000307,GO:0000781,GO:0001618,GO:0004672,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005789,GO:0005813,GO:0005829,GO:0005876,GO:0006260,GO:0006281,GO:0006367,GO:0006468,GO:0006915,GO:0006977,GO:0007077,GO:0007095,GO:0007098,GO:0007344,GO:0008353,GO:0010389,GO:0010971,GO:0014038,GO:0016020,GO:0016477,GO:0016572,GO:0016579,GO:0018105,GO:0018107,GO:0030332,GO:0030496,GO:0030855,GO:0031145,GO:0034501,GO:0035173,GO:0042752,GO:0043066,GO:0045995,GO:0046718,GO:0048511,GO:0051301,GO:0070062,GO:0072686,GO:0090166,GO:0097125,GO:0097472,GO:0097711,GO:1900182,GO:1901990,GO:1905448" "G2/M transition of mitotic cell cycle|activation of MAPK activity|microtubule cytoskeleton organization|cyclin-dependent protein kinase holoenzyme complex|chromosome, telomeric region|virus receptor activity|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|endoplasmic reticulum membrane|centrosome|cytosol|spindle microtubule|DNA replication|DNA repair|transcription initiation from RNA polymerase II promoter|protein phosphorylation|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|mitotic nuclear envelope disassembly|mitotic G2 DNA damage checkpoint|centrosome cycle|pronuclear fusion|RNA polymerase II CTD heptapeptide repeat kinase activity|regulation of G2/M transition of mitotic cell cycle|positive regulation of G2/M transition of mitotic cell cycle|regulation of Schwann cell differentiation|membrane|cell migration|histone phosphorylation|protein deubiquitination|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cyclin binding|midbody|epithelial cell differentiation|anaphase-promoting complex-dependent catabolic process|protein localization to kinetochore|histone kinase activity|regulation of circadian rhythm|negative regulation of apoptotic process|regulation of embryonic development|viral entry into host cell|rhythmic process|cell division|extracellular exosome|mitotic spindle|Golgi disassembly|cyclin B1-CDK1 complex|cyclin-dependent protein kinase activity|ciliary basal body-plasma membrane docking|positive regulation of protein localization to nucleus|regulation of mitotic cell cycle phase transition|positive regulation of mitochondrial ATP synthesis coupled electron transport" "hsa04110,hsa04114,hsa04115,hsa04218,hsa04540,hsa04914,hsa05170,hsa05203" Cell cycle|Oocyte meiosis|p53 signaling pathway|Cellular senescence|Gap junction|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection|Viral carcinogenesis CDK10 544.4662239 512.552764 576.3796837 1.12452751 0.169318956 0.674710448 1 9.166309788 10.75178435 8558 cyclin dependent kinase 10 "GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007089,GO:0007346,GO:0008285,GO:0018107,GO:0030030,GO:0032956,GO:0036064,GO:0043410,GO:1902018" protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|traversing start control point of mitotic cell cycle|regulation of mitotic cell cycle|negative regulation of cell population proliferation|peptidyl-threonine phosphorylation|cell projection organization|regulation of actin cytoskeleton organization|ciliary basal body|positive regulation of MAPK cascade|negative regulation of cilium assembly CDK11A 490.7868805 480.074173 501.499588 1.044629385 0.062991191 0.882738257 1 8.043024566 8.763903019 728642 cyclin dependent kinase 11A "GO:0000278,GO:0001558,GO:0004672,GO:0004674,GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0006355,GO:0006468,GO:0006915,GO:0007346,GO:0050684" "mitotic cell cycle|regulation of cell growth|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|regulation of mitotic cell cycle|regulation of mRNA processing" CDK11B 962.5865132 941.8791387 983.2938877 1.043970343 0.062080729 0.863701494 1 11.74368676 12.78817439 984 cyclin dependent kinase 11B "GO:0000278,GO:0001558,GO:0003723,GO:0004672,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006355,GO:0006468,GO:0006915,GO:0007346,GO:0050684" "mitotic cell cycle|regulation of cell growth|RNA binding|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|regulation of mitotic cell cycle|regulation of mRNA processing" CDK12 2958.887367 3074.301628 2843.473106 0.924916762 -0.11260456 0.72398847 1 12.88394969 12.429899 51755 cyclin dependent kinase 12 "GO:0000307,GO:0002944,GO:0004672,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006368,GO:0006397,GO:0006468,GO:0008024,GO:0008353,GO:0008380,GO:0016607,GO:0019901,GO:0019908,GO:0030332,GO:0032968,GO:0043405,GO:0043484,GO:0046777,GO:0051726,GO:0070816,GO:2000737" cyclin-dependent protein kinase holoenzyme complex|cyclin K-CDK12 complex|protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription elongation from RNA polymerase II promoter|mRNA processing|protein phosphorylation|cyclin/CDK positive transcription elongation factor complex|RNA polymerase II CTD heptapeptide repeat kinase activity|RNA splicing|nuclear speck|protein kinase binding|nuclear cyclin-dependent protein kinase holoenzyme complex|cyclin binding|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of MAP kinase activity|regulation of RNA splicing|protein autophosphorylation|regulation of cell cycle|phosphorylation of RNA polymerase II C-terminal domain|negative regulation of stem cell differentiation other CDK13 1769.589085 1721.365322 1817.812849 1.056029667 0.078650365 0.810419808 1 9.934033838 10.94252843 8621 cyclin dependent kinase 13 "GO:0000307,GO:0000380,GO:0002945,GO:0003723,GO:0004672,GO:0004693,GO:0005515,GO:0005524,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006368,GO:0006468,GO:0007088,GO:0007275,GO:0008024,GO:0008284,GO:0008353,GO:0016032,GO:0016607,GO:0019901,GO:0019908,GO:0030097,GO:0030332,GO:0032968,GO:0043312,GO:0070816,GO:1904813,GO:2000737" "cyclin-dependent protein kinase holoenzyme complex|alternative mRNA splicing, via spliceosome|cyclin K-CDK13 complex|RNA binding|protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|extracellular region|extracellular space|nucleus|nucleoplasm|Golgi apparatus|cytosol|transcription elongation from RNA polymerase II promoter|protein phosphorylation|regulation of mitotic nuclear division|multicellular organism development|cyclin/CDK positive transcription elongation factor complex|positive regulation of cell population proliferation|RNA polymerase II CTD heptapeptide repeat kinase activity|viral process|nuclear speck|protein kinase binding|nuclear cyclin-dependent protein kinase holoenzyme complex|hemopoiesis|cyclin binding|positive regulation of transcription elongation from RNA polymerase II promoter|neutrophil degranulation|phosphorylation of RNA polymerase II C-terminal domain|ficolin-1-rich granule lumen|negative regulation of stem cell differentiation" CDK14 70.63667927 46.68797455 94.58538399 2.025904634 1.018566263 0.181868472 1 0.427901051 0.904228685 5218 cyclin dependent kinase 14 "GO:0000083,GO:0000086,GO:0000308,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0016055,GO:0030332,GO:0051301,GO:0051726,GO:0060828" regulation of transcription involved in G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|cytoplasmic cyclin-dependent protein kinase holoenzyme complex|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein phosphorylation|Wnt signaling pathway|cyclin binding|cell division|regulation of cell cycle|regulation of canonical Wnt signaling pathway hsa05202 Transcriptional misregulation in cancer CDK15 3.941057666 0 7.882115332 Inf Inf 0.07384143 1 0 0.041227456 65061 cyclin dependent kinase 15 "GO:0000083,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0030332,GO:0046872,GO:0051726" regulation of transcription involved in G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|cyclin binding|metal ion binding|regulation of cell cycle CDK16 4919.94584 4616.019744 5223.871937 1.131683187 0.178470135 0.578212977 1 40.8643796 48.23760129 5127 cyclin dependent kinase 16 "GO:0000083,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006887,GO:0007283,GO:0008021,GO:0015630,GO:0030252,GO:0031175,GO:0031234,GO:0043005,GO:0051726,GO:0061178" regulation of transcription involved in G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|exocytosis|spermatogenesis|synaptic vesicle|microtubule cytoskeleton|growth hormone secretion|neuron projection development|extrinsic component of cytoplasmic side of plasma membrane|neuron projection|regulation of cell cycle|regulation of insulin secretion involved in cellular response to glucose stimulus CDK17 1256.568929 1304.218419 1208.919439 0.926930199 -0.109467392 0.748781177 1 14.20212039 13.73144213 5128 cyclin dependent kinase 17 "GO:0000083,GO:0004672,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0051726" regulation of transcription involved in G1/S transition of mitotic cell cycle|protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|regulation of cell cycle CDK18 37.46701778 35.52345889 39.41057666 1.109423966 0.149810797 0.899447359 1 0.53402727 0.617983541 5129 cyclin dependent kinase 18 "GO:0000083,GO:0004693,GO:0005515,GO:0005524,GO:0005575,GO:0005634,GO:0005737,GO:0006468,GO:0051726" regulation of transcription involved in G1/S transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|cellular_component|nucleus|cytoplasm|protein phosphorylation|regulation of cell cycle CDK19 746.1470299 694.2298824 798.0641774 1.149567597 0.201091302 0.590875404 1 3.99594209 4.791479441 23097 cyclin dependent kinase 19 "GO:0004693,GO:0005524,GO:0005634,GO:0005829,GO:0006468,GO:0008353,GO:0016592,GO:0043065,GO:0050729,GO:0051726,GO:0071222" cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytosol|protein phosphorylation|RNA polymerase II CTD heptapeptide repeat kinase activity|mediator complex|positive regulation of apoptotic process|positive regulation of inflammatory response|regulation of cell cycle|cellular response to lipopolysaccharide CDK2 2040.674617 1495.030141 2586.319093 1.729944448 0.790725711 0.014439043 0.530370717 31.76090709 57.31139565 1017 cyclin dependent kinase 2 "GO:0000082,GO:0000086,GO:0000307,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005813,GO:0005829,GO:0006260,GO:0006281,GO:0006468,GO:0006977,GO:0007099,GO:0007165,GO:0007265,GO:0008284,GO:0010389,GO:0010468,GO:0015030,GO:0016572,GO:0018105,GO:0019904,GO:0030332,GO:0031145,GO:0031571,GO:0035173,GO:0046872,GO:0051298,GO:0051301,GO:0051321,GO:0060968,GO:0071732,GO:0097123,GO:0097124,GO:0097134,GO:0097135,GO:0097472,GO:1901796" "G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|endosome|centrosome|cytosol|DNA replication|DNA repair|protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|centriole replication|signal transduction|Ras protein signal transduction|positive regulation of cell population proliferation|regulation of G2/M transition of mitotic cell cycle|regulation of gene expression|Cajal body|histone phosphorylation|peptidyl-serine phosphorylation|protein domain specific binding|cyclin binding|anaphase-promoting complex-dependent catabolic process|mitotic G1 DNA damage checkpoint|histone kinase activity|metal ion binding|centrosome duplication|cell division|meiotic cell cycle|regulation of gene silencing|cellular response to nitric oxide|cyclin A1-CDK2 complex|cyclin A2-CDK2 complex|cyclin E1-CDK2 complex|cyclin E2-CDK2 complex|cyclin-dependent protein kinase activity|regulation of signal transduction by p53 class mediator" "hsa04068,hsa04110,hsa04114,hsa04115,hsa04151,hsa04218,hsa04914,hsa04934,hsa05160,hsa05161,hsa05162,hsa05165,hsa05166,hsa05169,hsa05200,hsa05203,hsa05215,hsa05222,hsa05226" FoxO signaling pathway|Cell cycle|Oocyte meiosis|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Cushing syndrome|Hepatitis C|Hepatitis B|Measles|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Prostate cancer|Small cell lung cancer|Gastric cancer other CDK20 63.55895744 68.00204988 59.11586499 0.86932475 -0.202032876 0.813490313 1 1.436822666 1.30287018 23552 cyclin dependent kinase 20 "GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005929,GO:0006468,GO:0007049,GO:0007275,GO:0051301,GO:0051726" cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cilium|protein phosphorylation|cell cycle|multicellular organism development|cell division|regulation of cell cycle CDK2AP1 2148.954734 2161.856213 2136.053255 0.988064443 -0.017322955 0.958483549 1 68.34606155 70.43924527 8099 cyclin dependent kinase 2 associated protein 1 "GO:0001934,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006261,GO:0007049,GO:0048471,GO:0070182" positive regulation of protein phosphorylation|protein binding|nucleus|nucleoplasm|cytosol|DNA-dependent DNA replication|cell cycle|perinuclear region of cytoplasm|DNA polymerase binding CDK2AP2 1427.73623 1487.92545 1367.54701 0.919096458 -0.121711817 0.71648245 1 71.76969042 68.80469831 10263 cyclin dependent kinase 2 associated protein 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005874,GO:0070507,GO:2000035,GO:2000134" protein binding|nucleus|cytoplasm|microtubule|regulation of microtubule cytoskeleton organization|regulation of stem cell division|negative regulation of G1/S transition of mitotic cell cycle CDK3 87.0392783 90.33108119 83.74747541 0.927116938 -0.109176776 0.893307495 1 2.915838491 2.819771456 1018 cyclin dependent kinase 3 "GO:0000082,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0006468,GO:0006974,GO:0008283,GO:0045023,GO:0051301,GO:0051726" G1/S transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|protein phosphorylation|cellular response to DNA damage stimulus|cell population proliferation|G0 to G1 transition|cell division|regulation of cell cycle CDK4 4758.261277 4575.421505 4941.101049 1.079922591 0.110927904 0.729513101 1 124.2514521 139.9619643 1019 cyclin dependent kinase 4 "GO:0000079,GO:0000082,GO:0000307,GO:0000785,GO:0002088,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0005923,GO:0006367,GO:0006468,GO:0007165,GO:0007623,GO:0008284,GO:0008353,GO:0009636,GO:0010288,GO:0010468,GO:0010971,GO:0016538,GO:0016592,GO:0030332,GO:0031100,GO:0031965,GO:0032869,GO:0033574,GO:0040014,GO:0042493,GO:0043065,GO:0044877,GO:0045727,GO:0045787,GO:0045793,GO:0046626,GO:0046890,GO:0048146,GO:0048471,GO:0050994,GO:0051301,GO:0051726,GO:0055093,GO:0060612,GO:0071157,GO:0071222,GO:0071353,GO:0097129,GO:1904628,GO:1904637,GO:2000134" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|chromatin|lens development in camera-type eye|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytosol|bicellular tight junction|transcription initiation from RNA polymerase II promoter|protein phosphorylation|signal transduction|circadian rhythm|positive regulation of cell population proliferation|RNA polymerase II CTD heptapeptide repeat kinase activity|response to toxic substance|response to lead ion|regulation of gene expression|positive regulation of G2/M transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase regulator activity|mediator complex|cyclin binding|animal organ regeneration|nuclear membrane|cellular response to insulin stimulus|response to testosterone|regulation of multicellular organism growth|response to drug|positive regulation of apoptotic process|protein-containing complex binding|positive regulation of translation|positive regulation of cell cycle|positive regulation of cell size|regulation of insulin receptor signaling pathway|regulation of lipid biosynthetic process|positive regulation of fibroblast proliferation|perinuclear region of cytoplasm|regulation of lipid catabolic process|cell division|regulation of cell cycle|response to hyperoxia|adipose tissue development|negative regulation of cell cycle arrest|cellular response to lipopolysaccharide|cellular response to interleukin-4|cyclin D2-CDK4 complex|cellular response to phorbol 13-acetate 12-myristate|cellular response to ionomycin|negative regulation of G1/S transition of mitotic cell cycle "hsa01522,hsa04110,hsa04115,hsa04151,hsa04218,hsa04530,hsa04660,hsa04933,hsa04934,hsa05160,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05203,hsa05212,hsa05214,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225" Endocrine resistance|Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Tight junction|T cell receptor signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Hepatitis C|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|Glioma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma CDK5 703.2353256 791.6656553 614.8049959 0.776596776 -0.364762376 0.333967921 1 35.73535884 28.94740655 1020 cyclin dependent kinase 5 "GO:0000083,GO:0000226,GO:0001764,GO:0001963,GO:0002039,GO:0004672,GO:0004674,GO:0004693,GO:0005176,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0005886,GO:0006468,GO:0006886,GO:0006913,GO:0007005,GO:0007160,GO:0007268,GO:0007409,GO:0007416,GO:0007519,GO:0008017,GO:0008045,GO:0008542,GO:0009611,GO:0014044,GO:0014069,GO:0016020,GO:0016079,GO:0016241,GO:0016301,GO:0016310,GO:0016533,GO:0016572,GO:0018105,GO:0018107,GO:0019233,GO:0019901,GO:0021697,GO:0021766,GO:0021819,GO:0021954,GO:0022038,GO:0030027,GO:0030054,GO:0030175,GO:0030182,GO:0030334,GO:0030424,GO:0030425,GO:0030426,GO:0030517,GO:0030549,GO:0030866,GO:0031175,GO:0031397,GO:0031594,GO:0031914,GO:0032092,GO:0032801,GO:0034352,GO:0035249,GO:0035418,GO:0042501,GO:0042981,GO:0043005,GO:0043025,GO:0043113,GO:0043125,GO:0043204,GO:0043525,GO:0045786,GO:0045860,GO:0045861,GO:0045892,GO:0045956,GO:0046777,GO:0046826,GO:0046875,GO:0048148,GO:0048156,GO:0048167,GO:0048488,GO:0048489,GO:0048511,GO:0048675,GO:0048709,GO:0048813,GO:0050321,GO:0051301,GO:0051402,GO:0051879,GO:0051966,GO:0060079,GO:0061001,GO:0070509,GO:0071156,GO:0090314,GO:0098685,GO:0098793,GO:0098883,GO:0098978,GO:0099601,GO:0099635,GO:0099703,GO:0106310,GO:0106311,GO:1901215,GO:1901387,GO:1901796,GO:1903076,GO:1903421,GO:1904646,GO:2000251" "regulation of transcription involved in G1/S transition of mitotic cell cycle|microtubule cytoskeleton organization|neuron migration|synaptic transmission, dopaminergic|p53 binding|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ErbB-2 class receptor binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|microtubule|plasma membrane|protein phosphorylation|intracellular protein transport|nucleocytoplasmic transport|mitochondrion organization|cell-matrix adhesion|chemical synaptic transmission|axonogenesis|synapse assembly|skeletal muscle tissue development|microtubule binding|motor neuron axon guidance|visual learning|response to wounding|Schwann cell development|postsynaptic density|membrane|synaptic vesicle exocytosis|regulation of macroautophagy|kinase activity|phosphorylation|protein kinase 5 complex|histone phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sensory perception of pain|protein kinase binding|cerebellar cortex formation|hippocampus development|layer formation in cerebral cortex|central nervous system neuron development|corpus callosum development|lamellipodium|cell junction|filopodium|neuron differentiation|regulation of cell migration|axon|dendrite|growth cone|negative regulation of axon extension|acetylcholine receptor activator activity|cortical actin cytoskeleton organization|neuron projection development|negative regulation of protein ubiquitination|neuromuscular junction|negative regulation of synaptic plasticity|positive regulation of protein binding|receptor catabolic process|positive regulation of glial cell apoptotic process|synaptic transmission, glutamatergic|protein localization to synapse|serine phosphorylation of STAT protein|regulation of apoptotic process|neuron projection|neuronal cell body|receptor clustering|ErbB-3 class receptor binding|perikaryon|positive regulation of neuron apoptotic process|negative regulation of cell cycle|positive regulation of protein kinase activity|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of calcium ion-dependent exocytosis|protein autophosphorylation|negative regulation of protein export from nucleus|ephrin receptor binding|behavioral response to cocaine|tau protein binding|regulation of synaptic plasticity|synaptic vesicle endocytosis|synaptic vesicle transport|rhythmic process|axon extension|oligodendrocyte differentiation|dendrite morphogenesis|tau-protein kinase activity|cell division|neuron apoptotic process|Hsp90 protein binding|regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|regulation of dendritic spine morphogenesis|calcium ion import|regulation of cell cycle arrest|positive regulation of protein targeting to membrane|Schaffer collateral - CA1 synapse|presynapse|synapse pruning|glutamatergic synapse|regulation of neurotransmitter receptor activity|voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels|induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration|protein serine kinase activity|protein threonine kinase activity|negative regulation of neuron death|positive regulation of voltage-gated calcium channel activity|regulation of signal transduction by p53 class mediator|regulation of protein localization to plasma membrane|regulation of synaptic vesicle recycling|cellular response to amyloid-beta|positive regulation of actin cytoskeleton reorganization" "hsa04360,hsa05010,hsa05022,hsa05030" Axon guidance|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction CDK5R1 158.3467391 149.1985274 167.4949508 1.122631394 0.16688431 0.782571555 1 1.463847166 1.714150103 8851 cyclin dependent kinase 5 regulatory subunit 1 "GO:0000079,GO:0000226,GO:0001764,GO:0002020,GO:0004672,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007158,GO:0007213,GO:0007411,GO:0007413,GO:0007420,GO:0009792,GO:0014069,GO:0016020,GO:0016241,GO:0016301,GO:0016533,GO:0018105,GO:0018107,GO:0019901,GO:0021549,GO:0021722,GO:0021766,GO:0021819,GO:0030182,GO:0030295,GO:0030424,GO:0030425,GO:0030426,GO:0030517,GO:0031116,GO:0031175,GO:0031594,GO:0032147,GO:0032956,GO:0035235,GO:0035255,GO:0042501,GO:0043005,GO:0043014,GO:0043025,GO:0043197,GO:0043204,GO:0043231,GO:0043292,GO:0043525,GO:0043539,GO:0045296,GO:0045664,GO:0045737,GO:0045892,GO:0046875,GO:0048013,GO:0048471,GO:0048487,GO:0048511,GO:0051015,GO:0061001,GO:0061575,GO:0071158,GO:0090314,GO:0098693,GO:0098793,GO:1901796" "regulation of cyclin-dependent protein serine/threonine kinase activity|microtubule cytoskeleton organization|neuron migration|protease binding|protein kinase activity|calcium ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|neuron cell-cell adhesion|G protein-coupled acetylcholine receptor signaling pathway|axon guidance|axonal fasciculation|brain development|embryo development ending in birth or egg hatching|postsynaptic density|membrane|regulation of macroautophagy|kinase activity|protein kinase 5 complex|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein kinase binding|cerebellum development|superior olivary nucleus maturation|hippocampus development|layer formation in cerebral cortex|neuron differentiation|protein kinase activator activity|axon|dendrite|growth cone|negative regulation of axon extension|positive regulation of microtubule polymerization|neuron projection development|neuromuscular junction|activation of protein kinase activity|regulation of actin cytoskeleton organization|ionotropic glutamate receptor signaling pathway|ionotropic glutamate receptor binding|serine phosphorylation of STAT protein|neuron projection|alpha-tubulin binding|neuronal cell body|dendritic spine|perikaryon|intracellular membrane-bounded organelle|contractile fiber|positive regulation of neuron apoptotic process|protein serine/threonine kinase activator activity|cadherin binding|regulation of neuron differentiation|positive regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|ephrin receptor binding|ephrin receptor signaling pathway|perinuclear region of cytoplasm|beta-tubulin binding|rhythmic process|actin filament binding|regulation of dendritic spine morphogenesis|cyclin-dependent protein serine/threonine kinase activator activity|positive regulation of cell cycle arrest|positive regulation of protein targeting to membrane|regulation of synaptic vesicle cycle|presynapse|regulation of signal transduction by p53 class mediator" "hsa05010,hsa05022,hsa05030" Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction CDK5R2 26.89905477 20.29911937 33.49899016 1.65026815 0.722700465 0.489163718 1 0.412883046 0.7107183 8941 cyclin dependent kinase 5 regulatory subunit 2 "GO:0000079,GO:0001764,GO:0003779,GO:0005737,GO:0005886,GO:0008289,GO:0016020,GO:0016533,GO:0021549,GO:0021722,GO:0021766,GO:0021819,GO:0030426,GO:0043005,GO:0045737,GO:0045956,GO:0061575" regulation of cyclin-dependent protein serine/threonine kinase activity|neuron migration|actin binding|cytoplasm|plasma membrane|lipid binding|membrane|protein kinase 5 complex|cerebellum development|superior olivary nucleus maturation|hippocampus development|layer formation in cerebral cortex|growth cone|neuron projection|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of calcium ion-dependent exocytosis|cyclin-dependent protein serine/threonine kinase activator activity CDK5RAP1 964.8957733 998.7166729 931.0748736 0.932271283 -0.101178267 0.777506972 1 23.9495626 23.28926714 51654 CDK5 regulatory subunit associated protein 1 "GO:0005575,GO:0005739,GO:0005829,GO:0007420,GO:0019901,GO:0035597,GO:0035600,GO:0044877,GO:0045664,GO:0045736,GO:0045903,GO:0046872,GO:0051539,GO:0070131,GO:0070900" "cellular_component|mitochondrion|cytosol|brain development|protein kinase binding|N6-isopentenyladenosine methylthiotransferase activity|tRNA methylthiolation|protein-containing complex binding|regulation of neuron differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of translational fidelity|metal ion binding|4 iron, 4 sulfur cluster binding|positive regulation of mitochondrial translation|mitochondrial tRNA modification" CDK5RAP2 2150.801299 1850.26473 2451.337868 1.324857913 0.405837643 0.206070433 1 15.05371586 20.8031427 55755 CDK5 regulatory subunit associated protein 2 "GO:0000086,GO:0000132,GO:0000226,GO:0000242,GO:0000922,GO:0000976,GO:0001578,GO:0005515,GO:0005516,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005856,GO:0005874,GO:0007059,GO:0007098,GO:0007099,GO:0007420,GO:0008017,GO:0008274,GO:0010389,GO:0015631,GO:0019901,GO:0022008,GO:0030054,GO:0031023,GO:0031116,GO:0035371,GO:0043015,GO:0045664,GO:0045665,GO:0045893,GO:0046600,GO:0048471,GO:0070062,GO:0090266,GO:0097431,GO:0097711" "G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|microtubule cytoskeleton organization|pericentriolar material|spindle pole|transcription regulatory region sequence-specific DNA binding|microtubule bundle formation|protein binding|calmodulin binding|cytoplasm|Golgi apparatus|centrosome|cytosol|cytoskeleton|microtubule|chromosome segregation|centrosome cycle|centriole replication|brain development|microtubule binding|gamma-tubulin ring complex|regulation of G2/M transition of mitotic cell cycle|tubulin binding|protein kinase binding|neurogenesis|cell junction|microtubule organizing center organization|positive regulation of microtubule polymerization|microtubule plus-end|gamma-tubulin binding|regulation of neuron differentiation|negative regulation of neuron differentiation|positive regulation of transcription, DNA-templated|negative regulation of centriole replication|perinuclear region of cytoplasm|extracellular exosome|regulation of mitotic cell cycle spindle assembly checkpoint|mitotic spindle pole|ciliary basal body-plasma membrane docking" CDK5RAP3 1202.123049 1151.975024 1252.271073 1.08706443 0.120437452 0.72618963 1 19.0976992 21.65470461 80279 CDK5 regulatory subunit associated protein 3 "GO:0000079,GO:0001889,GO:0001933,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0007095,GO:0007346,GO:0007420,GO:0008283,GO:0010921,GO:0016020,GO:0016032,GO:0019901,GO:0030262,GO:0030332,GO:0030968,GO:0031398,GO:0032088,GO:0032991,GO:0034976,GO:0043231,GO:0043407,GO:0044387,GO:0044389,GO:0044818,GO:0045664,GO:0045944,GO:0051019,GO:0051059,GO:0060318,GO:0071569,GO:0071901,GO:0097371,GO:1900182,GO:1901798,GO:1903363,GO:2000060" regulation of cyclin-dependent protein serine/threonine kinase activity|liver development|negative regulation of protein phosphorylation|protein binding|nucleus|nucleolus|cytoplasm|centrosome|cytosol|microtubule|mitotic G2 DNA damage checkpoint|regulation of mitotic cell cycle|brain development|cell population proliferation|regulation of phosphatase activity|membrane|viral process|protein kinase binding|apoptotic nuclear changes|cyclin binding|endoplasmic reticulum unfolded protein response|positive regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|protein-containing complex|response to endoplasmic reticulum stress|intracellular membrane-bounded organelle|negative regulation of MAP kinase activity|negative regulation of protein kinase activity by regulation of protein phosphorylation|ubiquitin-like protein ligase binding|mitotic G2/M transition checkpoint|regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|mitogen-activated protein kinase binding|NF-kappaB binding|definitive erythrocyte differentiation|protein ufmylation|negative regulation of protein serine/threonine kinase activity|MDM2/MDM4 family protein binding|positive regulation of protein localization to nucleus|positive regulation of signal transduction by p53 class mediator|negative regulation of cellular protein catabolic process|positive regulation of ubiquitin-dependent protein catabolic process CDK6 1705.552095 2024.837157 1386.267034 0.684631369 -0.546600699 0.09474838 1 8.531685424 6.092668622 1021 cyclin dependent kinase 6 "GO:0000082,GO:0000307,GO:0001726,GO:0001954,GO:0003323,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0007050,GO:0008285,GO:0008353,GO:0009615,GO:0010468,GO:0014002,GO:0016592,GO:0021542,GO:0021670,GO:0030332,GO:0042063,GO:0043697,GO:0045596,GO:0045638,GO:0045646,GO:0045656,GO:0045668,GO:0045786,GO:0048146,GO:0048699,GO:0050680,GO:0051301,GO:0051726,GO:0098770,GO:2000134,GO:2000145,GO:2000773" G1/S transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|ruffle|positive regulation of cell-matrix adhesion|type B pancreatic cell development|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|cell cycle arrest|negative regulation of cell population proliferation|RNA polymerase II CTD heptapeptide repeat kinase activity|response to virus|regulation of gene expression|astrocyte development|mediator complex|dentate gyrus development|lateral ventricle development|cyclin binding|gliogenesis|cell dedifferentiation|negative regulation of cell differentiation|negative regulation of myeloid cell differentiation|regulation of erythrocyte differentiation|negative regulation of monocyte differentiation|negative regulation of osteoblast differentiation|negative regulation of cell cycle|positive regulation of fibroblast proliferation|generation of neurons|negative regulation of epithelial cell proliferation|cell division|regulation of cell cycle|FBXO family protein binding|negative regulation of G1/S transition of mitotic cell cycle|regulation of cell motility|negative regulation of cellular senescence "hsa04110,hsa04115,hsa04151,hsa04218,hsa04934,hsa05160,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05169,hsa05200,hsa05203,hsa05206,hsa05212,hsa05214,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225" Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Cushing syndrome|Hepatitis C|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Pancreatic cancer|Glioma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma CDK7 1096.639135 979.4325095 1213.845761 1.239335788 0.309567127 0.372559799 1 30.96429549 40.0282058 1022 cyclin dependent kinase 7 "GO:0000079,GO:0000082,GO:0000086,GO:0000439,GO:0001650,GO:0004672,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005675,GO:0005737,GO:0005829,GO:0005886,GO:0006283,GO:0006294,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006468,GO:0007050,GO:0008022,GO:0008094,GO:0008353,GO:0016301,GO:0019907,GO:0042795,GO:0045944,GO:0048471,GO:0050821,GO:0051301,GO:0070516,GO:0070816,GO:0070985" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|transcription factor TFIIH core complex|fibrillar center|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription factor TFIIH holo complex|cytoplasm|cytosol|plasma membrane|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein phosphorylation|cell cycle arrest|protein C-terminus binding|DNA-dependent ATPase activity|RNA polymerase II CTD heptapeptide repeat kinase activity|kinase activity|cyclin-dependent protein kinase activating kinase holoenzyme complex|snRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|protein stabilization|cell division|CAK-ERCC2 complex|phosphorylation of RNA polymerase II C-terminal domain|transcription factor TFIIK complex" "hsa03022,hsa03420,hsa04110" Basal transcription factors|Nucleotide excision repair|Cell cycle other CDK8 448.2275155 466.8797455 429.5752856 0.920098355 -0.120140007 0.778977289 1 5.67454093 5.446041127 1024 cyclin dependent kinase 8 "GO:0004672,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006367,GO:0006468,GO:0008353,GO:0016592,GO:0032991,GO:0045944,GO:0051726" protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|transcription initiation from RNA polymerase II promoter|protein phosphorylation|RNA polymerase II CTD heptapeptide repeat kinase activity|mediator complex|protein-containing complex|positive regulation of transcription by RNA polymerase II|regulation of cell cycle other CDK9 1446.364458 1515.329261 1377.399654 0.908977138 -0.137684086 0.680395284 1 30.90861107 29.305449 1025 cyclin dependent kinase 9 "GO:0000978,GO:0001223,GO:0003677,GO:0003682,GO:0004672,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0006282,GO:0006366,GO:0006367,GO:0006368,GO:0006468,GO:0007346,GO:0008023,GO:0008024,GO:0008283,GO:0008353,GO:0010613,GO:0016020,GO:0016301,GO:0016592,GO:0016605,GO:0019901,GO:0031056,GO:0031297,GO:0033129,GO:0036464,GO:0042493,GO:0042795,GO:0045944,GO:0050434,GO:0051147,GO:0070691,GO:0070816,GO:0071157,GO:0071345,GO:0097322,GO:1900364,GO:1903839,GO:2001168" RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription coactivator binding|DNA binding|chromatin binding|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|regulation of DNA repair|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|protein phosphorylation|regulation of mitotic cell cycle|transcription elongation factor complex|cyclin/CDK positive transcription elongation factor complex|cell population proliferation|RNA polymerase II CTD heptapeptide repeat kinase activity|positive regulation of cardiac muscle hypertrophy|membrane|kinase activity|mediator complex|PML body|protein kinase binding|regulation of histone modification|replication fork processing|positive regulation of histone phosphorylation|cytoplasmic ribonucleoprotein granule|response to drug|snRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|positive regulation of viral transcription|regulation of muscle cell differentiation|P-TEFb complex|phosphorylation of RNA polymerase II C-terminal domain|negative regulation of cell cycle arrest|cellular response to cytokine stimulus|7SK snRNA binding|negative regulation of mRNA polyadenylation|positive regulation of mRNA 3'-UTR binding|positive regulation of histone H2B ubiquitination hsa05202 Transcriptional misregulation in cancer other CDKAL1 222.7276574 206.0360616 239.4192532 1.162025965 0.216642305 0.682277088 1 1.781628763 2.159478962 54901 CDK5 regulatory subunit associated protein 1 like 1 "GO:0005515,GO:0005783,GO:0005789,GO:0005791,GO:0006400,GO:0008150,GO:0016020,GO:0016021,GO:0035598,GO:0035600,GO:0046872,GO:0051539,GO:0061712,GO:1990145" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|tRNA modification|biological_process|membrane|integral component of membrane|N6-threonylcarbomyladenosine methylthiotransferase activity|tRNA methylthiolation|metal ion binding|4 iron, 4 sulfur cluster binding|tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase|maintenance of translational fidelity" CDKL1 117.5649078 122.8096722 112.3201435 0.914587113 -0.128807504 0.852841355 1 0.60634399 0.578442354 8814 cyclin dependent kinase like 1 "GO:0004693,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0007507,GO:0035869,GO:0043231,GO:0051726,GO:0070062,GO:1902017" cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|heart development|ciliary transition zone|intracellular membrane-bounded organelle|regulation of cell cycle|extracellular exosome|regulation of cilium assembly CDKL3 37.48186355 36.53841486 38.42531225 1.051641468 0.072642936 0.96908079 1 0.399426249 0.438147396 51265 cyclin dependent kinase like 3 "GO:0004672,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006464,GO:0006468,GO:0030517,GO:0050775,GO:0051726,GO:0097484" protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cellular protein modification process|protein phosphorylation|negative regulation of axon extension|positive regulation of dendrite morphogenesis|regulation of cell cycle|dendrite extension CDKL5 148.793732 136.0040998 161.5833643 1.188077158 0.248628533 0.68214919 1 1.959638082 2.428490711 6792 cyclin dependent kinase like 5 "GO:0001764,GO:0004672,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0006468,GO:0016301,GO:0031267,GO:0032587,GO:0032839,GO:0036064,GO:0043547,GO:0044294,GO:0045773,GO:0046777,GO:0048471,GO:0050773,GO:0050775,GO:0051726,GO:0060999,GO:0097542,GO:0098978,GO:0099092,GO:0099175,GO:1902017" "neuron migration|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|centrosome|protein phosphorylation|kinase activity|small GTPase binding|ruffle membrane|dendrite cytoplasm|ciliary basal body|positive regulation of GTPase activity|dendritic growth cone|positive regulation of axon extension|protein autophosphorylation|perinuclear region of cytoplasm|regulation of dendrite development|positive regulation of dendrite morphogenesis|regulation of cell cycle|positive regulation of dendritic spine development|ciliary tip|glutamatergic synapse|postsynaptic density, intracellular component|regulation of postsynapse organization|regulation of cilium assembly" CDKN1A 1666.6292 1350.906394 1982.352006 1.467423661 0.553285453 0.091596589 1 25.19095845 38.55814557 1026 cyclin dependent kinase inhibitor 1A "GO:0000079,GO:0000082,GO:0000086,GO:0000307,GO:0004860,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0006367,GO:0006606,GO:0006974,GO:0006977,GO:0006978,GO:0007050,GO:0007095,GO:0007265,GO:0007507,GO:0008285,GO:0009636,GO:0010165,GO:0010243,GO:0010629,GO:0016604,GO:0019221,GO:0019901,GO:0019912,GO:0030308,GO:0030332,GO:0030890,GO:0031100,GO:0031625,GO:0031668,GO:0032091,GO:0032991,GO:0034198,GO:0034605,GO:0042060,GO:0042246,GO:0042326,GO:0042493,GO:0042771,GO:0043066,GO:0043068,GO:0044877,GO:0045736,GO:0045860,GO:0046685,GO:0046872,GO:0048146,GO:0048471,GO:0050821,GO:0051412,GO:0055093,GO:0060574,GO:0070557,GO:0071479,GO:0071480,GO:0071493,GO:0071850,GO:0090398,GO:0090399,GO:0090400,GO:0097193,GO:0140311,GO:1902806,GO:1904030,GO:1904031,GO:1904706,GO:1905179,GO:2000134,GO:2000279,GO:2000379" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|protein kinase inhibitor activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein import into nucleus|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|cell cycle arrest|mitotic G2 DNA damage checkpoint|Ras protein signal transduction|heart development|negative regulation of cell population proliferation|response to toxic substance|response to X-ray|response to organonitrogen compound|negative regulation of gene expression|nuclear body|cytokine-mediated signaling pathway|protein kinase binding|cyclin-dependent protein kinase activating kinase activity|negative regulation of cell growth|cyclin binding|positive regulation of B cell proliferation|animal organ regeneration|ubiquitin protein ligase binding|cellular response to extracellular stimulus|negative regulation of protein binding|protein-containing complex|cellular response to amino acid starvation|cellular response to heat|wound healing|tissue regeneration|negative regulation of phosphorylation|response to drug|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of apoptotic process|positive regulation of programmed cell death|protein-containing complex binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of protein kinase activity|response to arsenic-containing substance|metal ion binding|positive regulation of fibroblast proliferation|perinuclear region of cytoplasm|protein stabilization|response to corticosterone|response to hyperoxia|intestinal epithelial cell maturation|PCNA-p21 complex|cellular response to ionizing radiation|cellular response to gamma radiation|cellular response to UV-B|mitotic cell cycle arrest|cellular senescence|replicative senescence|stress-induced premature senescence|intrinsic apoptotic signaling pathway|protein sequestering activity|regulation of cell cycle G1/S phase transition|negative regulation of cyclin-dependent protein kinase activity|positive regulation of cyclin-dependent protein kinase activity|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of cardiac muscle tissue regeneration|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of DNA biosynthetic process|positive regulation of reactive oxygen species metabolic process" "hsa01522,hsa01524,hsa04012,hsa04066,hsa04068,hsa04110,hsa04115,hsa04151,hsa04218,hsa04630,hsa04921,hsa04928,hsa04934,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05202,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05217,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" "Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|JAK-STAT signaling pathway|Oxytocin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" CDKN1B 820.4278513 720.6187375 920.2369651 1.277009488 0.352769244 0.33478753 1 15.13761795 20.16357773 1027 cyclin dependent kinase inhibitor 1B "GO:0000079,GO:0000082,GO:0004860,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0006977,GO:0007050,GO:0007507,GO:0008285,GO:0010942,GO:0019901,GO:0019903,GO:0030308,GO:0030332,GO:0031464,GO:0033673,GO:0042326,GO:0043231,GO:0044877,GO:0045732,GO:0045736,GO:0045786,GO:0045787,GO:0045892,GO:0045930,GO:0048102,GO:0051087,GO:0071285,GO:0071850,GO:1902806,GO:1904030,GO:1904706,GO:1905179" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|protein kinase inhibitor activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell cycle arrest|heart development|negative regulation of cell population proliferation|positive regulation of cell death|protein kinase binding|protein phosphatase binding|negative regulation of cell growth|cyclin binding|Cul4A-RING E3 ubiquitin ligase complex|negative regulation of kinase activity|negative regulation of phosphorylation|intracellular membrane-bounded organelle|protein-containing complex binding|positive regulation of protein catabolic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of cell cycle|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|autophagic cell death|chaperone binding|cellular response to lithium ion|mitotic cell cycle arrest|regulation of cell cycle G1/S phase transition|negative regulation of cyclin-dependent protein kinase activity|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of cardiac muscle tissue regeneration" "hsa01522,hsa04012,hsa04066,hsa04068,hsa04110,hsa04151,hsa04933,hsa04934,hsa05162,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05206,hsa05215,hsa05220,hsa05222,hsa05226" Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|PI3K-Akt signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Measles|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Prostate cancer|Chronic myeloid leukemia|Small cell lung cancer|Gastric cancer CDKN1C 106.7297209 89.31612522 124.1433165 1.389931731 0.475014024 0.477688284 1 2.331725079 3.380545169 1028 cyclin dependent kinase inhibitor 1C "GO:0004860,GO:0004861,GO:0005515,GO:0005634,GO:0005737,GO:0007050,GO:0030511,GO:0033673,GO:0042326,GO:0044877,GO:0045736,GO:0045892,GO:0045893,GO:0045930,GO:0050680,GO:1904030" "protein kinase inhibitor activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|cytoplasm|cell cycle arrest|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of kinase activity|negative regulation of phosphorylation|protein-containing complex binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|negative regulation of epithelial cell proliferation|negative regulation of cyclin-dependent protein kinase activity" hsa04110 Cell cycle CDKN2A 1341.717351 1332.637186 1350.797515 1.013627361 0.019527374 0.956085128 1 14.59000697 15.4258731 1029 cyclin dependent kinase inhibitor 2A "GO:0000082,GO:0001953,GO:0003723,GO:0004861,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007050,GO:0007265,GO:0008285,GO:0019901,GO:0030308,GO:0032088,GO:0034393,GO:0035985,GO:0035986,GO:0042326,GO:0045736,GO:0045892,GO:0051059,GO:0090398,GO:0090399,GO:2000111,GO:2000134,GO:2000774" "G1/S transition of mitotic cell cycle|negative regulation of cell-matrix adhesion|RNA binding|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|cytoplasm|cytosol|cell cycle arrest|Ras protein signal transduction|negative regulation of cell population proliferation|protein kinase binding|negative regulation of cell growth|negative regulation of NF-kappaB transcription factor activity|positive regulation of smooth muscle cell apoptotic process|senescence-associated heterochromatin focus|senescence-associated heterochromatin focus assembly|negative regulation of phosphorylation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|NF-kappaB binding|cellular senescence|replicative senescence|positive regulation of macrophage apoptotic process|negative regulation of G1/S transition of mitotic cell cycle|positive regulation of cellular senescence" "hsa01522,hsa01524,hsa04110,hsa04115,hsa04218,hsa04934,hsa05163,hsa05166,hsa05200,hsa05203,hsa05206,hsa05212,hsa05214,hsa05218,hsa05219,hsa05220,hsa05223,hsa05225" Endocrine resistance|Platinum drug resistance|Cell cycle|p53 signaling pathway|Cellular senescence|Cushing syndrome|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Pancreatic cancer|Glioma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Non-small cell lung cancer|Hepatocellular carcinoma CDKN2AIP 393.7492219 346.0999852 441.3984586 1.275349545 0.350892712 0.421589665 1 4.992521585 6.64148372 55602 CDKN2A interacting protein "GO:0001652,GO:0002039,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006974,GO:0009967,GO:0030307,GO:0030308,GO:0031647" granular component|p53 binding|RNA binding|protein binding|nucleoplasm|nucleolus|cellular response to DNA damage stimulus|positive regulation of signal transduction|positive regulation of cell growth|negative regulation of cell growth|regulation of protein stability CDKN2AIPNL 793.9511592 830.2339821 757.6683363 0.912596151 -0.131951526 0.72201365 1 17.01676338 16.19837774 91368 CDKN2A interacting protein N-terminal like "GO:0005515,GO:0005654,GO:0005730" protein binding|nucleoplasm|nucleolus CDKN2B 180.3464417 205.0211056 155.6717778 0.759296353 -0.397265016 0.478638038 1 2.606324229 2.064218591 1030 cyclin dependent kinase inhibitor 2B "GO:0000079,GO:0000086,GO:0004861,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007050,GO:0008285,GO:0019901,GO:0030219,GO:0030511,GO:0031668,GO:0031670,GO:0042326,GO:0045736,GO:0045944,GO:0048536,GO:0050680,GO:0070316,GO:0090398,GO:2000134" regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|cytoplasm|cytosol|cell cycle arrest|negative regulation of cell population proliferation|protein kinase binding|megakaryocyte differentiation|positive regulation of transforming growth factor beta receptor signaling pathway|cellular response to extracellular stimulus|cellular response to nutrient|negative regulation of phosphorylation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|spleen development|negative regulation of epithelial cell proliferation|regulation of G0 to G1 transition|cellular senescence|negative regulation of G1/S transition of mitotic cell cycle "hsa04068,hsa04110,hsa04218,hsa04350,hsa04934,hsa05166,hsa05200,hsa05203,hsa05222,hsa05226" FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Cushing syndrome|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer|Gastric cancer CDKN2C 621.252022 575.4800341 667.02401 1.159074113 0.212972817 0.584570467 1 13.31477092 16.097589 1031 cyclin dependent kinase inhibitor 2C "GO:0000079,GO:0000082,GO:0004861,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007050,GO:0008285,GO:0019901,GO:0030308,GO:0042326,GO:0045736,GO:0048709,GO:2000134" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|cytoplasm|cytosol|cell cycle arrest|negative regulation of cell population proliferation|protein kinase binding|negative regulation of cell growth|negative regulation of phosphorylation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|oligodendrocyte differentiation|negative regulation of G1/S transition of mitotic cell cycle "hsa01522,hsa04110,hsa04934,hsa05166,hsa05202" Endocrine resistance|Cell cycle|Cushing syndrome|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer CDKN2D 247.0893222 221.2604011 272.9182434 1.233470797 0.30272356 0.550382101 1 7.863900882 10.1177241 1032 cyclin dependent kinase inhibitor 2D "GO:0000079,GO:0000082,GO:0000731,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007050,GO:0007605,GO:0008285,GO:0009411,GO:0019901,GO:0030308,GO:0032526,GO:0033280,GO:0042326,GO:0043154,GO:0045736,GO:0048102,GO:0097129,GO:1902230,GO:2000134" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|DNA synthesis involved in DNA repair|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell cycle arrest|sensory perception of sound|negative regulation of cell population proliferation|response to UV|protein kinase binding|negative regulation of cell growth|response to retinoic acid|response to vitamin D|negative regulation of phosphorylation|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|autophagic cell death|cyclin D2-CDK4 complex|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of G1/S transition of mitotic cell cycle "hsa04068,hsa04110" FoxO signaling pathway|Cell cycle CDKN3 667.7942604 625.2128765 710.3756443 1.136214034 0.184234627 0.631096132 1 31.53867189 37.37829436 1033 cyclin dependent kinase inhibitor 3 "GO:0000079,GO:0000082,GO:0004722,GO:0004725,GO:0005515,GO:0005737,GO:0005829,GO:0007050,GO:0008138,GO:0008285,GO:0035335,GO:0048471,GO:0106306,GO:0106307" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytoplasm|cytosol|cell cycle arrest|protein tyrosine/serine/threonine phosphatase activity|negative regulation of cell population proliferation|peptidyl-tyrosine dephosphorylation|perinuclear region of cytoplasm|protein serine phosphatase activity|protein threonine phosphatase activity CDNF 17.49450548 17.25425146 17.7347595 1.027848675 0.039627879 1 1 0.616702165 0.661181331 441549 cerebral dopamine neurotrophic factor "GO:0005615,GO:0005783,GO:0007165,GO:0008083,GO:0031175,GO:0071542" extracellular space|endoplasmic reticulum|signal transduction|growth factor activity|neuron projection development|dopaminergic neuron differentiation CDON 255.7852336 310.5765263 200.993941 0.64716398 -0.627796782 0.207411156 1 1.805510263 1.218793778 50937 "cell adhesion associated, oncogene regulated" "GO:0001708,GO:0001934,GO:0002088,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007224,GO:0007520,GO:0009952,GO:0010172,GO:0014816,GO:0021987,GO:0043393,GO:0043410,GO:0045663,GO:0045666,GO:0045944,GO:0048643,GO:0051057,GO:0051149,GO:0060059,GO:0062023,GO:2000179" cell fate specification|positive regulation of protein phosphorylation|lens development in camera-type eye|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|smoothened signaling pathway|myoblast fusion|anterior/posterior pattern specification|embryonic body morphogenesis|skeletal muscle satellite cell differentiation|cerebral cortex development|regulation of protein binding|positive regulation of MAPK cascade|positive regulation of myoblast differentiation|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of skeletal muscle tissue development|positive regulation of small GTPase mediated signal transduction|positive regulation of muscle cell differentiation|embryonic retina morphogenesis in camera-type eye|collagen-containing extracellular matrix|positive regulation of neural precursor cell proliferation hsa04340 Hedgehog signaling pathway CDPF1 168.7662443 154.2733072 183.2591815 1.187886517 0.248397016 0.668719477 1 3.17617836 3.935462378 150383 cysteine rich DPF motif domain containing 1 GO:0005515 protein binding CDR2 653.0004484 624.1979205 681.8029763 1.092286523 0.127351346 0.742528947 1 11.7478345 13.38475187 1039 cerebellar degeneration related protein 2 "GO:0003674,GO:0005515" molecular_function|protein binding CDR2L 1196.320826 1092.092622 1300.54903 1.190877956 0.25202557 0.461907919 1 15.64214893 19.43030433 30850 cerebellar degeneration related protein 2 like "GO:0005515,GO:0042802" protein binding|identical protein binding CDS1 100.3848852 93.37594909 107.3938214 1.150122943 0.201788087 0.776722091 1 1.049758582 1.259359233 1040 CDP-diacylglycerol synthase 1 "GO:0004142,GO:0004605,GO:0005515,GO:0005783,GO:0005789,GO:0006657,GO:0006661,GO:0007165,GO:0007602,GO:0016021,GO:0016024,GO:0045600,GO:0140042" diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|CDP-choline pathway|phosphatidylinositol biosynthetic process|signal transduction|phototransduction|integral component of membrane|CDP-diacylglycerol biosynthetic process|positive regulation of fat cell differentiation|lipid droplet formation "hsa00564,hsa04070" Glycerophospholipid metabolism|Phosphatidylinositol signaling system CDS2 5487.382678 4442.462274 6532.303082 1.470423985 0.556232205 0.085394093 1 22.4299713 34.40227997 8760 CDP-diacylglycerol synthase 2 "GO:0004605,GO:0005515,GO:0005743,GO:0005783,GO:0005789,GO:0006655,GO:0016020,GO:0016021,GO:0016024,GO:0140042" phosphatidate cytidylyltransferase activity|protein binding|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|phosphatidylglycerol biosynthetic process|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|lipid droplet formation "hsa00564,hsa04070" Glycerophospholipid metabolism|Phosphatidylinositol signaling system CDT1 831.2914921 587.6595057 1074.923478 1.829160369 0.871181567 0.017395461 0.570891215 11.17225256 21.3161348 81620 chromatin licensing and DNA replication factor 1 "GO:0000076,GO:0000082,GO:0000083,GO:0000278,GO:0000776,GO:0000777,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007059,GO:0016604,GO:0030174,GO:0031334,GO:0033044,GO:0033262,GO:0035563,GO:0045740,GO:0051301,GO:0051315,GO:0051383,GO:0070182,GO:0071163,GO:0072708,GO:1902426,GO:1902595,GO:1905341,GO:1905342,GO:2000105" DNA replication checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|kinetochore|condensed chromosome kinetochore|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|chromosome segregation|nuclear body|regulation of DNA-dependent DNA replication initiation|positive regulation of protein-containing complex assembly|regulation of chromosome organization|regulation of nuclear cell cycle DNA replication|positive regulation of chromatin binding|positive regulation of DNA replication|cell division|attachment of mitotic spindle microtubules to kinetochore|kinetochore organization|DNA polymerase binding|DNA replication preinitiation complex assembly|response to sorbitol|deactivation of mitotic spindle assembly checkpoint|regulation of DNA replication origin binding|negative regulation of protein localization to kinetochore|positive regulation of protein localization to kinetochore|positive regulation of DNA-dependent DNA replication CDV3 2607.318447 2446.043884 2768.59301 1.131865634 0.178702703 0.575412704 1 27.73304087 32.74223305 55573 CDV3 homolog "GO:0003674,GO:0005737,GO:0005829,GO:0005886,GO:0008150" molecular_function|cytoplasm|cytosol|plasma membrane|biological_process CDYL 572.2263336 591.7193296 552.7333377 0.934114047 -0.098329394 0.807103588 1 7.240516207 7.054810664 9425 chromodomain Y like "GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005694,GO:0005737,GO:0007283,GO:0007286,GO:0016607,GO:0030674,GO:0035064,GO:0045892,GO:0060816,GO:0120092,GO:0120094" "chromatin binding|transcription corepressor activity|protein binding|nucleus|chromosome|cytoplasm|spermatogenesis|spermatid development|nuclear speck|protein-macromolecule adaptor activity|methylated histone binding|negative regulation of transcription, DNA-templated|random inactivation of X chromosome|crotonyl-CoA hydratase activity|negative regulation of peptidyl-lysine crotonylation" CDYL2 788.7954695 713.5140458 864.0768933 1.211015955 0.276217872 0.454085433 1 3.813928157 4.817683913 124359 chromodomain Y like 2 "GO:0003714,GO:0003824,GO:0005515,GO:0005634,GO:0045892" "transcription corepressor activity|catalytic activity|protein binding|nucleus|negative regulation of transcription, DNA-templated" CEACAM19 17.92775458 13.19442759 22.66108158 1.71747364 0.780287957 0.51449497 1 0.181590003 0.325310398 56971 CEA cell adhesion molecule 19 "GO:0005515,GO:0016021" protein binding|integral component of membrane CEBPA 42.09370274 48.71788648 35.469519 0.728059478 -0.457871781 0.6209807 1 0.948630943 0.72041057 1050 CCAAT enhancer binding protein alpha "GO:0000050,GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001889,GO:0001892,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0006091,GO:0006355,GO:0006357,GO:0007005,GO:0007219,GO:0008134,GO:0008203,GO:0008285,GO:0016032,GO:0019221,GO:0019900,GO:0030099,GO:0030225,GO:0030324,GO:0030851,GO:0032436,GO:0042593,GO:0042803,GO:0043032,GO:0043231,GO:0045444,GO:0045600,GO:0045669,GO:0045736,GO:0045892,GO:0045944,GO:0045945,GO:0048469,GO:0048839,GO:0050729,GO:0050872,GO:0050873,GO:0055088,GO:0070102,GO:0071285,GO:0071356,GO:0071407,GO:0090575" "urea cycle|negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|embryonic placenta development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|generation of precursor metabolites and energy|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|mitochondrion organization|Notch signaling pathway|transcription factor binding|cholesterol metabolic process|negative regulation of cell population proliferation|viral process|cytokine-mediated signaling pathway|kinase binding|myeloid cell differentiation|macrophage differentiation|lung development|granulocyte differentiation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|glucose homeostasis|protein homodimerization activity|positive regulation of macrophage activation|intracellular membrane-bounded organelle|fat cell differentiation|positive regulation of fat cell differentiation|positive regulation of osteoblast differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase III|cell maturation|inner ear development|positive regulation of inflammatory response|white fat cell differentiation|brown fat cell differentiation|lipid homeostasis|interleukin-6-mediated signaling pathway|cellular response to lithium ion|cellular response to tumor necrosis factor|cellular response to organic cyclic compound|RNA polymerase II transcription regulator complex" "hsa04932,hsa05200,hsa05202,hsa05221" Non-alcoholic fatty liver disease|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia TF_bZIP CEBPB 2411.260231 2514.045934 2308.474528 0.918230847 -0.123071196 0.700610451 1 60.40206713 57.85216417 1051 CCAAT enhancer binding protein beta "GO:0000122,GO:0000779,GO:0000785,GO:0000977,GO:0000978,GO:0000979,GO:0000981,GO:0001227,GO:0001228,GO:0001541,GO:0001892,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0006953,GO:0006954,GO:0006955,GO:0007613,GO:0016363,GO:0019900,GO:0030182,GO:0032675,GO:0032753,GO:0033598,GO:0034976,GO:0035035,GO:0035259,GO:0036488,GO:0042130,GO:0042742,GO:0042803,GO:0042826,GO:0043524,GO:0044389,GO:0045595,GO:0045600,GO:0045669,GO:0045670,GO:0045893,GO:0045944,GO:0046982,GO:0050729,GO:0050873,GO:0060644,GO:0070059,GO:0070169,GO:0071222,GO:0071230,GO:0071347,GO:0071407,GO:0072574,GO:0097421,GO:0120162,GO:1901329,GO:1990440,GO:1990837,GO:2000120,GO:2001198" "negative regulation of transcription by RNA polymerase II|condensed chromosome, centromeric region|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|ovarian follicle development|embryonic placenta development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|acute-phase response|inflammatory response|immune response|memory|nuclear matrix|kinase binding|neuron differentiation|regulation of interleukin-6 production|positive regulation of interleukin-4 production|mammary gland epithelial cell proliferation|response to endoplasmic reticulum stress|histone acetyltransferase binding|glucocorticoid receptor binding|CHOP-C/EBP complex|negative regulation of T cell proliferation|defense response to bacterium|protein homodimerization activity|histone deacetylase binding|negative regulation of neuron apoptotic process|ubiquitin-like protein ligase binding|regulation of cell differentiation|positive regulation of fat cell differentiation|positive regulation of osteoblast differentiation|regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of inflammatory response|brown fat cell differentiation|mammary gland epithelial cell differentiation|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of biomineral tissue development|cellular response to lipopolysaccharide|cellular response to amino acid stimulus|cellular response to interleukin-1|cellular response to organic cyclic compound|hepatocyte proliferation|liver regeneration|positive regulation of cold-induced thermogenesis|regulation of odontoblast differentiation|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|sequence-specific double-stranded DNA binding|positive regulation of sodium-dependent phosphate transport|regulation of dendritic cell differentiation" "hsa04657,hsa04668,hsa05152,hsa05202" IL-17 signaling pathway|TNF signaling pathway|Tuberculosis|Transcriptional misregulation in cancer TF_bZIP CEBPD 857.5210031 764.2618442 950.780162 1.244050281 0.315044796 0.385067874 1 30.91626698 40.11815134 1052 CCAAT enhancer binding protein delta "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005654,GO:0006357,GO:0006366,GO:0019221,GO:0045595,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|cytokine-mediated signaling pathway|regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TF_bZIP CEBPG 549.4128349 446.5806261 652.2450438 1.460531437 0.546493412 0.171287617 1 5.262385591 8.016956113 1054 CCAAT enhancer binding protein gamma "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001889,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006955,GO:0008134,GO:0016071,GO:0030183,GO:0032729,GO:0042267,GO:0042802,GO:0043353,GO:0043388,GO:0043433,GO:0043565,GO:0044377,GO:0044877,GO:0045739,GO:0045944,GO:0051091,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|immune response|transcription factor binding|mRNA metabolic process|B cell differentiation|positive regulation of interferon-gamma production|natural killer cell mediated cytotoxicity|identical protein binding|enucleate erythrocyte differentiation|positive regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending|protein-containing complex binding|positive regulation of DNA repair|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|sequence-specific double-stranded DNA binding" hsa05152 Tuberculosis CEBPZ 813.2947057 872.8621328 753.7272787 0.863512404 -0.211711193 0.564302282 1 13.21201069 11.90017715 10153 CCAAT enhancer binding protein zeta "GO:0003677,GO:0003713,GO:0003723,GO:0005634,GO:0045944" DNA binding|transcription coactivator activity|RNA binding|nucleus|positive regulation of transcription by RNA polymerase II other CEBPZOS 534.2572811 488.1938208 580.3207413 1.188709723 0.249396459 0.536471559 1 6.684318675 8.287983759 100505876 CEBPZ opposite strand "GO:0016021,GO:0031966" integral component of membrane|mitochondrial membrane CECR2 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.019235122 0 27443 CECR2 histone acetyl-lysine reader "GO:0001842,GO:0001843,GO:0005634,GO:0006309,GO:0007010,GO:0007338,GO:0016192,GO:0043044,GO:0060122,GO:0061640,GO:0090102,GO:0090537,GO:0097194" neural fold formation|neural tube closure|nucleus|apoptotic DNA fragmentation|cytoskeleton organization|single fertilization|vesicle-mediated transport|ATP-dependent chromatin remodeling|inner ear receptor cell stereocilium organization|cytoskeleton-dependent cytokinesis|cochlea development|CERF complex|execution phase of apoptosis CEL 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.107946113 0.043720843 1056 carboxyl ester lipase "GO:0003824,GO:0004771,GO:0004806,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005887,GO:0006629,GO:0006707,GO:0007158,GO:0007268,GO:0008126,GO:0008201,GO:0009062,GO:0009986,GO:0016787,GO:0018350,GO:0030157,GO:0030299,GO:0038023,GO:0042043,GO:0044241,GO:0044258,GO:0045202,GO:0046514,GO:0048488,GO:0050804,GO:0070062,GO:0097104,GO:0097105,GO:0098793" catalytic activity|sterol esterase activity|triglyceride lipase activity|protein binding|extracellular region|extracellular space|cytoplasm|integral component of plasma membrane|lipid metabolic process|cholesterol catabolic process|neuron cell-cell adhesion|chemical synaptic transmission|acetylesterase activity|heparin binding|fatty acid catabolic process|cell surface|hydrolase activity|protein esterification|pancreatic juice secretion|intestinal cholesterol absorption|signaling receptor activity|neurexin family protein binding|lipid digestion|intestinal lipid catabolic process|synapse|ceramide catabolic process|synaptic vesicle endocytosis|modulation of chemical synaptic transmission|extracellular exosome|postsynaptic membrane assembly|presynaptic membrane assembly|presynapse "hsa00100,hsa00561,hsa04972,hsa04975" Steroid biosynthesis|Glycerolipid metabolism|Pancreatic secretion|Fat digestion and absorption CELF1 2396.424603 2476.492563 2316.356643 0.935337613 -0.09644089 0.763526158 1 20.20061391 19.70828787 10658 CUGBP Elav-like family member 1 "GO:0000381,GO:0000900,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006376,GO:0006397,GO:0007281,GO:0008285,GO:0009792,GO:0010494,GO:0010628,GO:0010629,GO:0010942,GO:0016020,GO:0016246,GO:0016441,GO:0036002,GO:0042835,GO:0043484,GO:0050727,GO:0061157,GO:0097356,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|translation repressor activity, mRNA regulatory element binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA splice site selection|mRNA processing|germ cell development|negative regulation of cell population proliferation|embryo development ending in birth or egg hatching|cytoplasmic stress granule|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell death|membrane|RNA interference|posttranscriptional gene silencing|pre-mRNA binding|BRE binding|regulation of RNA splicing|regulation of inflammatory response|mRNA destabilization|perinucleolar compartment|ribonucleoprotein complex" CELF5 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.046730854 0.023658938 60680 CUGBP Elav-like family member 5 "GO:0000381,GO:0003723,GO:0003729,GO:0005515,GO:0005575,GO:0005634,GO:0005737,GO:0006376,GO:0036002,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|cellular_component|nucleus|cytoplasm|mRNA splice site selection|pre-mRNA binding|ribonucleoprotein complex" CELF6 5.030242514 7.104691779 2.95579325 0.416033987 -1.265226703 0.543955984 1 0.100679232 0.043690261 60677 CUGBP Elav-like family member 6 "GO:0000381,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0006376,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|cytoplasm|mRNA splice site selection|ribonucleoprotein complex" CELSR1 3086.078273 3046.897817 3125.258729 1.025718261 0.036634513 0.909276246 1 12.60328533 13.48428073 9620 cadherin EGF LAG seven-pass G-type receptor 1 "GO:0001736,GO:0001764,GO:0001843,GO:0004930,GO:0005509,GO:0005654,GO:0005886,GO:0007156,GO:0007186,GO:0007266,GO:0007417,GO:0016021,GO:0032956,GO:0042249,GO:0045176,GO:0048105,GO:0060071,GO:0060488,GO:0060489,GO:0060490,GO:0090251,GO:0098609" "establishment of planar polarity|neuron migration|neural tube closure|G protein-coupled receptor activity|calcium ion binding|nucleoplasm|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|G protein-coupled receptor signaling pathway|Rho protein signal transduction|central nervous system development|integral component of membrane|regulation of actin cytoskeleton organization|establishment of planar polarity of embryonic epithelium|apical protein localization|establishment of body hair planar orientation|Wnt signaling pathway, planar cell polarity pathway|orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis|planar dichotomous subdivision of terminal units involved in lung branching morphogenesis|lateral sprouting involved in lung morphogenesis|protein localization involved in establishment of planar polarity|cell-cell adhesion" CELSR2 2189.583656 2784.024221 1595.14309 0.572963079 -0.803485918 0.012584596 0.495847719 12.80081755 7.650331869 1952 cadherin EGF LAG seven-pass G-type receptor 2 "GO:0001764,GO:0003341,GO:0004930,GO:0005509,GO:0005737,GO:0005886,GO:0006355,GO:0007156,GO:0007186,GO:0016021,GO:0016055,GO:0021591,GO:0021999,GO:0022407,GO:0032880,GO:0033326,GO:0048813,GO:0060071,GO:0060271,GO:0098609" "neuron migration|cilium movement|G protein-coupled receptor activity|calcium ion binding|cytoplasm|plasma membrane|regulation of transcription, DNA-templated|homophilic cell adhesion via plasma membrane adhesion molecules|G protein-coupled receptor signaling pathway|integral component of membrane|Wnt signaling pathway|ventricular system development|neural plate anterior/posterior regionalization|regulation of cell-cell adhesion|regulation of protein localization|cerebrospinal fluid secretion|dendrite morphogenesis|Wnt signaling pathway, planar cell polarity pathway|cilium assembly|cell-cell adhesion" CELSR3 355.6181036 399.8926515 311.3435556 0.778567834 -0.361105353 0.422132814 1 1.697238923 1.378336858 1951 cadherin EGF LAG seven-pass G-type receptor 3 "GO:0004930,GO:0005509,GO:0005515,GO:0005886,GO:0007156,GO:0007186,GO:0007275,GO:0016021,GO:0060071,GO:0098609" "G protein-coupled receptor activity|calcium ion binding|protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|G protein-coupled receptor signaling pathway|multicellular organism development|integral component of membrane|Wnt signaling pathway, planar cell polarity pathway|cell-cell adhesion" CEMIP 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.01390235 0.021115482 57214 cell migration inducing hyaluronidase 1 "GO:0004415,GO:0005515,GO:0005540,GO:0005576,GO:0005634,GO:0005737,GO:0005783,GO:0005886,GO:0005905,GO:0007605,GO:0010800,GO:0030213,GO:0030214,GO:0030335,GO:0030665,GO:0032050,GO:0045334,GO:0046923,GO:0051281,GO:0090314,GO:1900020" hyalurononglucosaminidase activity|protein binding|hyaluronic acid binding|extracellular region|nucleus|cytoplasm|endoplasmic reticulum|plasma membrane|clathrin-coated pit|sensory perception of sound|positive regulation of peptidyl-threonine phosphorylation|hyaluronan biosynthetic process|hyaluronan catabolic process|positive regulation of cell migration|clathrin-coated vesicle membrane|clathrin heavy chain binding|clathrin-coated endocytic vesicle|ER retention sequence binding|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of protein targeting to membrane|positive regulation of protein kinase C activity CEMIP2 541.3483648 669.8709391 412.8257905 0.616276609 -0.698350062 0.081794232 1 5.374085206 3.454587216 23670 cell migration inducing hyaluronidase 2 "GO:0001525,GO:0004415,GO:0005509,GO:0005886,GO:0005887,GO:0016021,GO:0030214,GO:0043231,GO:0045296,GO:0070062,GO:1903670" angiogenesis|hyalurononglucosaminidase activity|calcium ion binding|plasma membrane|integral component of plasma membrane|integral component of membrane|hyaluronan catabolic process|intracellular membrane-bounded organelle|cadherin binding|extracellular exosome|regulation of sprouting angiogenesis CENATAC 228.084507 235.4697847 220.6992293 0.937271972 -0.093460354 0.864132404 1 8.079751969 7.899135956 338657 centrosomal AT-AC splicing factor "GO:0005515,GO:0005737,GO:0005813,GO:0010826,GO:0042176" protein binding|cytoplasm|centrosome|negative regulation of centrosome duplication|regulation of protein catabolic process CEND1 9.015837508 10.14955968 7.882115332 0.776596776 -0.364762376 0.872363928 1 0.320273765 0.259437576 51286 cell cycle exit and neuronal differentiation 1 "GO:0003674,GO:0005515,GO:0005739,GO:0007628,GO:0008150,GO:0016021,GO:0021686,GO:0021702,GO:0021933,GO:0021941,GO:0031982" molecular_function|protein binding|mitochondrion|adult walking behavior|biological_process|integral component of membrane|cerebellar granular layer maturation|cerebellar Purkinje cell differentiation|radial glia guided migration of cerebellar granule cell|negative regulation of cerebellar granule cell precursor proliferation|vesicle CENPA 431.4389263 396.8477836 466.030069 1.174329524 0.231837295 0.587354274 1 14.47007937 17.7246155 1058 centromere protein A "GO:0000132,GO:0000281,GO:0000775,GO:0000778,GO:0000779,GO:0000786,GO:0000939,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0005829,GO:0016032,GO:0034080,GO:0046982,GO:0051382,GO:0071459" "establishment of mitotic spindle orientation|mitotic cytokinesis|chromosome, centromeric region|condensed nuclear chromosome kinetochore|condensed chromosome, centromeric region|nucleosome|condensed chromosome inner kinetochore|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|cytosol|viral process|CENP-A containing nucleosome assembly|protein heterodimerization activity|kinetochore assembly|protein localization to chromosome, centromeric region" chromosome_remodelling_factor CENPB 5868.334602 6304.906476 5431.762728 0.861513608 -0.21505451 0.506836982 1 110.4917891 99.29058686 1059 centromere protein B "GO:0000775,GO:0000779,GO:0003677,GO:0003682,GO:0003696,GO:0005634,GO:0005654,GO:0005694,GO:0005721,GO:0016604,GO:0019237,GO:0043565" "chromosome, centromeric region|condensed chromosome, centromeric region|DNA binding|chromatin binding|satellite DNA binding|nucleus|nucleoplasm|chromosome|pericentric heterochromatin|nuclear body|centromeric DNA binding|sequence-specific DNA binding" CENPBD1 110.6235196 119.7648043 101.4822349 0.847346059 -0.238976803 0.724433419 1 2.241561283 1.981195625 92806 CENPB DNA-binding domain containing 1 "GO:0003677,GO:0005634" DNA binding|nucleus CENPC 319.0257488 255.768904 382.2825936 1.494640621 0.579798637 0.211709761 1 1.784760635 2.782484089 1060 centromere protein C "GO:0000278,GO:0000776,GO:0000778,GO:0000779,GO:0003677,GO:0005515,GO:0005654,GO:0005721,GO:0005829,GO:0007059,GO:0016604,GO:0019237,GO:0030496,GO:0034080,GO:0042802,GO:0051301,GO:0051315,GO:0051382,GO:0051455" "mitotic cell cycle|kinetochore|condensed nuclear chromosome kinetochore|condensed chromosome, centromeric region|DNA binding|protein binding|nucleoplasm|pericentric heterochromatin|cytosol|chromosome segregation|nuclear body|centromeric DNA binding|midbody|CENP-A containing nucleosome assembly|identical protein binding|cell division|attachment of mitotic spindle microtubules to kinetochore|kinetochore assembly|monopolar spindle attachment to meiosis I kinetochore" CENPE 1179.860082 1212.872382 1146.847781 0.945563439 -0.080753841 0.815800371 1 7.192097811 7.09352635 1062 centromere protein E "GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0000779,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005828,GO:0005829,GO:0005874,GO:0006890,GO:0007018,GO:0007052,GO:0007059,GO:0007079,GO:0007080,GO:0007275,GO:0008017,GO:0008574,GO:0015630,GO:0016020,GO:0019886,GO:0030071,GO:0030496,GO:0043515,GO:0045860,GO:0051233,GO:0051301,GO:0051310,GO:0051315,GO:0051382,GO:0099606,GO:0099607,GO:1990023" "mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed chromosome, centromeric region|microtubule motor activity|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|kinetochore microtubule|cytosol|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|mitotic spindle organization|chromosome segregation|mitotic chromosome movement towards spindle pole|mitotic metaphase plate congression|multicellular organism development|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|microtubule cytoskeleton|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|regulation of mitotic metaphase/anaphase transition|midbody|kinetochore binding|positive regulation of protein kinase activity|spindle midzone|cell division|metaphase plate congression|attachment of mitotic spindle microtubules to kinetochore|kinetochore assembly|microtubule plus-end directed mitotic chromosome migration|lateral attachment of mitotic spindle microtubules to kinetochore|mitotic spindle midzone" CENPF 5174.722799 5026.061955 5323.383643 1.059155993 0.082915086 0.796946088 1 25.63209215 28.3178263 1063 centromere protein F "GO:0000278,GO:0000775,GO:0000776,GO:0000785,GO:0000922,GO:0000940,GO:0001822,GO:0003682,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005813,GO:0005819,GO:0005829,GO:0005930,GO:0007059,GO:0007094,GO:0007517,GO:0008017,GO:0008022,GO:0008134,GO:0010389,GO:0015031,GO:0016202,GO:0016363,GO:0021591,GO:0030154,GO:0030496,GO:0036064,GO:0042493,GO:0042803,GO:0045120,GO:0045892,GO:0048471,GO:0051301,GO:0051310,GO:0051382,GO:0051726,GO:0070840,GO:0071897,GO:0097539" "mitotic cell cycle|chromosome, centromeric region|kinetochore|chromatin|spindle pole|condensed chromosome outer kinetochore|kidney development|chromatin binding|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|centrosome|spindle|cytosol|axoneme|chromosome segregation|mitotic spindle assembly checkpoint|muscle organ development|microtubule binding|protein C-terminus binding|transcription factor binding|regulation of G2/M transition of mitotic cell cycle|protein transport|regulation of striated muscle tissue development|nuclear matrix|ventricular system development|cell differentiation|midbody|ciliary basal body|response to drug|protein homodimerization activity|pronucleus|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm|cell division|metaphase plate congression|kinetochore assembly|regulation of cell cycle|dynein complex binding|DNA biosynthetic process|ciliary transition fiber" CENPH 739.270468 628.2577444 850.2831915 1.353398663 0.436586869 0.242436129 1 23.50002836 33.17493337 64946 centromere protein H "GO:0000776,GO:0000777,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0007052,GO:0007059,GO:0034080,GO:0043515,GO:0051382,GO:0051383" kinetochore|condensed chromosome kinetochore|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|mitotic spindle organization|chromosome segregation|CENP-A containing nucleosome assembly|kinetochore binding|kinetochore assembly|kinetochore organization CENPI 1228.379776 993.641893 1463.117659 1.472479843 0.558247885 0.101833915 1 7.575561723 11.63536815 2491 centromere protein I "GO:0000776,GO:0005515,GO:0005654,GO:0005829,GO:0007548,GO:0016604,GO:0034080" kinetochore|protein binding|nucleoplasm|cytosol|sex differentiation|nuclear body|CENP-A containing nucleosome assembly CENPJ 529.0016303 499.3583364 558.6449242 1.118725539 0.161856138 0.690654492 1 3.369402892 3.931809129 55835 centromere protein J "GO:0000086,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0005886,GO:0007020,GO:0007099,GO:0008275,GO:0010389,GO:0015631,GO:0019901,GO:0019904,GO:0030954,GO:0042802,GO:0043015,GO:0045893,GO:0046427,GO:0046599,GO:0046785,GO:0051301,GO:0060271,GO:0061511,GO:0097711,GO:1903724,GO:1904951" "G2/M transition of mitotic cell cycle|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|centriole|cytosol|microtubule|plasma membrane|microtubule nucleation|centriole replication|gamma-tubulin small complex|regulation of G2/M transition of mitotic cell cycle|tubulin binding|protein kinase binding|protein domain specific binding|astral microtubule nucleation|identical protein binding|gamma-tubulin binding|positive regulation of transcription, DNA-templated|positive regulation of receptor signaling pathway via JAK-STAT|regulation of centriole replication|microtubule polymerization|cell division|cilium assembly|centriole elongation|ciliary basal body-plasma membrane docking|positive regulation of centriole elongation|positive regulation of establishment of protein localization" CENPK 557.089831 398.8776956 715.3019664 1.793286449 0.842605954 0.034859769 0.836264269 3.84721922 7.19635419 64105 centromere protein K "GO:0000070,GO:0000941,GO:0005515,GO:0005654,GO:0005829,GO:0034080,GO:0051382" mitotic sister chromatid segregation|condensed nuclear chromosome inner kinetochore|protein binding|nucleoplasm|cytosol|CENP-A containing nucleosome assembly|kinetochore assembly CENPL 375.029198 346.0999852 403.9584108 1.167172575 0.223017889 0.616513649 1 5.559385754 6.76827216 91687 centromere protein L "GO:0000775,GO:0005515,GO:0005654,GO:0005829,GO:0034080" "chromosome, centromeric region|protein binding|nucleoplasm|cytosol|CENP-A containing nucleosome assembly" CENPM 619.7350313 505.4480723 734.0219903 1.452220378 0.538260402 0.165677012 1 14.42206296 21.84619688 79019 centromere protein M "GO:0000777,GO:0005654,GO:0005829,GO:0034080" condensed chromosome kinetochore|nucleoplasm|cytosol|CENP-A containing nucleosome assembly CENPN 805.5800994 648.5568638 962.603335 1.484223495 0.56970835 0.12078358 1 12.60925803 19.52112147 55839 centromere protein N "GO:0000777,GO:0005654,GO:0005829,GO:0007059,GO:0034080,GO:0051382" condensed chromosome kinetochore|nucleoplasm|cytosol|chromosome segregation|CENP-A containing nucleosome assembly|kinetochore assembly CENPO 1200.043156 1211.857426 1188.228886 0.980502211 -0.028407211 0.936320844 1 14.94795506 15.2878457 79172 centromere protein O "GO:0000778,GO:0005515,GO:0005654,GO:0005829,GO:0016604,GO:0031511,GO:0034080" condensed nuclear chromosome kinetochore|protein binding|nucleoplasm|cytosol|nuclear body|Mis6-Sim4 complex|CENP-A containing nucleosome assembly CENPP 110.4305245 106.5703767 114.2906723 1.072443167 0.100901196 0.890999209 1 1.046821882 1.171016484 401541 centromere protein P "GO:0000775,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0034080" "chromosome, centromeric region|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|CENP-A containing nucleosome assembly" CENPQ 148.7640405 133.9741878 163.5538931 1.220786599 0.287811031 0.633707598 1 3.763349962 4.792148738 55166 centromere protein Q "GO:0000776,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0015629,GO:0034080,GO:0051310,GO:1905342" kinetochore|protein binding|nucleus|nucleoplasm|cytosol|actin cytoskeleton|CENP-A containing nucleosome assembly|metaphase plate congression|positive regulation of protein localization to kinetochore CENPS 7.000771347 7.104691779 6.896850916 0.970745971 -0.042834281 1 1 0.39759953 0.402594084 378708 centromere protein S "GO:0000712,GO:0000777,GO:0003677,GO:0003682,GO:0003690,GO:0005515,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0031297,GO:0031398,GO:0034080,GO:0036297,GO:0043240,GO:0046982,GO:0051301,GO:0051382,GO:0071821" resolution of meiotic recombination intermediates|condensed chromosome kinetochore|DNA binding|chromatin binding|double-stranded DNA binding|protein binding|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|replication fork processing|positive regulation of protein ubiquitination|CENP-A containing nucleosome assembly|interstrand cross-link repair|Fanconi anaemia nuclear complex|protein heterodimerization activity|cell division|kinetochore assembly|FANCM-MHF complex hsa03460 Fanconi anemia pathway CENPS-CORT 103.263728 121.7947162 84.73273982 0.695701279 -0.523460122 0.438041067 1 3.135980025 2.275684331 100526739 CENPS-CORT readthrough hsa03460 Fanconi anemia pathway CENPT 440.0836194 381.6234441 498.5437948 1.306376226 0.385570442 0.361945699 1 7.60042515 10.35671641 80152 centromere protein T "GO:0000278,GO:0000775,GO:0000776,GO:0000778,GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0007059,GO:0016604,GO:0034080,GO:0046982,GO:0051276,GO:0051301,GO:0051382,GO:1903394" "mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed nuclear chromosome kinetochore|DNA binding|protein binding|nucleoplasm|cytosol|chromosome segregation|nuclear body|CENP-A containing nucleosome assembly|protein heterodimerization activity|chromosome organization|cell division|kinetochore assembly|protein localization to kinetochore involved in kinetochore assembly" CENPU 425.933619 357.2645009 494.6027371 1.384416128 0.469277654 0.271125464 1 6.838316937 9.874879509 79682 centromere protein U "GO:0000777,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0016032,GO:0034080,GO:0034451,GO:0043009" condensed chromosome kinetochore|protein binding|nucleus|nucleoplasm|cytosol|viral process|CENP-A containing nucleosome assembly|centriolar satellite|chordate embryonic development CENPV 242.4450699 240.5445645 244.3455753 1.015801691 0.02261878 0.973384879 1 10.76213216 11.40310654 201161 centromere protein V "GO:0000776,GO:0000777,GO:0001667,GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007049,GO:0015630,GO:0016846,GO:0030496,GO:0031508,GO:0031965,GO:0032467,GO:0033044,GO:0034508,GO:0046872,GO:0051233,GO:0051301" kinetochore|condensed chromosome kinetochore|ameboidal-type cell migration|molecular_function|protein binding|nucleus|nucleoplasm|cytosol|cell cycle|microtubule cytoskeleton|carbon-sulfur lyase activity|midbody|pericentric heterochromatin assembly|nuclear membrane|positive regulation of cytokinesis|regulation of chromosome organization|centromere complex assembly|metal ion binding|spindle midzone|cell division CENPW 410.2678655 431.3562866 389.1794445 0.902222726 -0.148444469 0.734058364 1 17.79045129 16.74235925 387103 centromere protein W "GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0007059,GO:0016363,GO:0034080,GO:0046982,GO:0051276,GO:0051301,GO:0051382" "mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|DNA binding|protein binding|nucleoplasm|nucleolus|chromosome segregation|nuclear matrix|CENP-A containing nucleosome assembly|protein heterodimerization activity|chromosome organization|cell division|kinetochore assembly" CENPX 556.7590185 612.0184489 501.499588 0.81941907 -0.287326627 0.471283722 1 34.59439215 29.56839155 201254 centromere protein X "GO:0000712,GO:0000777,GO:0003677,GO:0003690,GO:0005515,GO:0005654,GO:0031297,GO:0031398,GO:0034080,GO:0036297,GO:0043240,GO:0051301,GO:0051382,GO:0071821" resolution of meiotic recombination intermediates|condensed chromosome kinetochore|DNA binding|double-stranded DNA binding|protein binding|nucleoplasm|replication fork processing|positive regulation of protein ubiquitination|CENP-A containing nucleosome assembly|interstrand cross-link repair|Fanconi anaemia nuclear complex|cell division|kinetochore assembly|FANCM-MHF complex hsa03460 Fanconi anemia pathway CEP104 1173.825769 1069.763591 1277.887948 1.19455173 0.256469331 0.455367342 1 8.136319563 10.13792068 9731 centrosomal protein 104 "GO:0000922,GO:0005515,GO:0005737,GO:0005814,GO:0005929" spindle pole|protein binding|cytoplasm|centriole|cilium CEP112 358.8547288 250.6941242 467.0153334 1.862889028 0.897541736 0.04575689 0.966026298 1.33131729 2.586928866 201134 centrosomal protein 112 "GO:0005737,GO:0005813,GO:0005886,GO:0060077,GO:0097120" cytoplasm|centrosome|plasma membrane|inhibitory synapse|receptor localization to synapse CEP120 765.5878159 642.467128 888.7085037 1.383274669 0.468087653 0.2068265 1 5.221228104 7.533503958 153241 centrosomal protein 120 "GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0007098,GO:0008022,GO:0010825,GO:0021987,GO:0022008,GO:0022027,GO:0030953,GO:0045724,GO:1903724,GO:1904951" protein binding|cytoplasm|centrosome|centriole|centrosome cycle|protein C-terminus binding|positive regulation of centrosome duplication|cerebral cortex development|neurogenesis|interkinetic nuclear migration|astral microtubule organization|positive regulation of cilium assembly|positive regulation of centriole elongation|positive regulation of establishment of protein localization CEP126 108.6854039 88.30116925 129.0696386 1.461697956 0.547645224 0.408788729 1 0.578543689 0.882083563 57562 centrosomal protein 126 "GO:0005515,GO:0005737,GO:0005813,GO:0007052,GO:0030496,GO:0031122,GO:0060271,GO:0097546,GO:1905515" protein binding|cytoplasm|centrosome|mitotic spindle organization|midbody|cytoplasmic microtubule organization|cilium assembly|ciliary base|non-motile cilium assembly CEP128 408.4688051 342.0401613 474.8974488 1.388425987 0.473450274 0.272467463 1 1.37649007 1.993479373 145508 centrosomal protein 128 "GO:0000922,GO:0005737,GO:0005814,GO:0008104,GO:0120103" spindle pole|cytoplasm|centriole|protein localization|centriolar subdistal appendage CEP131 413.0509527 352.189721 473.9121844 1.345616172 0.42826695 0.319495789 1 4.876207468 6.844146595 22994 centrosomal protein 131 "GO:0000086,GO:0001669,GO:0002177,GO:0005515,GO:0005813,GO:0005829,GO:0007275,GO:0007288,GO:0008284,GO:0010389,GO:0010824,GO:0015630,GO:0034451,GO:0035735,GO:0035869,GO:0036064,GO:0042803,GO:0043231,GO:0044877,GO:0045171,GO:0060271,GO:0071539,GO:0090316,GO:0097711,GO:0120212,GO:1905198,GO:1905515,GO:1990953" G2/M transition of mitotic cell cycle|acrosomal vesicle|manchette|protein binding|centrosome|cytosol|multicellular organism development|sperm axoneme assembly|positive regulation of cell population proliferation|regulation of G2/M transition of mitotic cell cycle|regulation of centrosome duplication|microtubule cytoskeleton|centriolar satellite|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|protein homodimerization activity|intracellular membrane-bounded organelle|protein-containing complex binding|intercellular bridge|cilium assembly|protein localization to centrosome|positive regulation of intracellular protein transport|ciliary basal body-plasma membrane docking|sperm head-tail coupling apparatus|manchette assembly|non-motile cilium assembly|intramanchette transport CEP135 242.6232192 252.7240361 232.5224023 0.920064454 -0.120193164 0.819055979 1 2.232614839 2.142633985 9662 centrosomal protein 135 "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0008022,GO:0010389,GO:0010457,GO:0097711,GO:1902857,GO:1904951" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|cytosol|centriole replication|protein C-terminus binding|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|ciliary basal body-plasma membrane docking|positive regulation of non-motile cilium assembly|positive regulation of establishment of protein localization CEP152 294.7234671 244.6043884 344.8425458 1.409797053 0.495487494 0.298011901 1 1.066857506 1.568841052 22995 centrosomal protein 152 "GO:0000086,GO:0000242,GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0010389,GO:0019901,GO:0051298,GO:0097711,GO:0098535,GO:0098536" G2/M transition of mitotic cell cycle|pericentriolar material|protein binding|nucleoplasm|centrosome|centriole|cytosol|centriole replication|regulation of G2/M transition of mitotic cell cycle|protein kinase binding|centrosome duplication|ciliary basal body-plasma membrane docking|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|deuterosome CEP162 160.3914968 154.2733072 166.5096864 1.079316244 0.110117642 0.859003501 1 1.207635049 1.359566177 22832 centrosomal protein 162 "GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005879,GO:0060271,GO:0097711" protein binding|nucleus|centrosome|centriole|spindle|cytosol|axonemal microtubule|cilium assembly|ciliary basal body-plasma membrane docking CEP164 1221.751387 1180.393791 1263.108982 1.070074234 0.097710884 0.776247867 1 6.868426166 7.666322251 22897 centrosomal protein 164 "GO:0000086,GO:0005515,GO:0005615,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0006281,GO:0010389,GO:0051301,GO:0060271,GO:0097539,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|extracellular space|nucleoplasm|centrosome|centriole|cytosol|DNA repair|regulation of G2/M transition of mitotic cell cycle|cell division|cilium assembly|ciliary transition fiber|ciliary basal body-plasma membrane docking CEP170 2920.505355 2908.863805 2932.146904 1.00800419 0.011501636 0.972342526 1 15.37665065 16.16739372 9859 centrosomal protein 170 "GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0072686,GO:0120103" protein binding|centrosome|centriole|cytosol|microtubule|mitotic spindle|centriolar subdistal appendage CEP170B 2380.966937 2194.334804 2567.59907 1.170103607 0.22663628 0.478267498 1 12.54632159 15.31287239 283638 centrosomal protein 170B "GO:0005737,GO:0005874" cytoplasm|microtubule CEP19 96.71105155 111.6451565 81.77694657 0.73247196 -0.449154563 0.516919054 1 2.620219331 2.001910143 84984 centrosomal protein 19 "GO:0000922,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005929,GO:0034454,GO:0036064,GO:0060271,GO:0097712" "spindle pole|protein binding|cytoplasm|centrosome|centriole|cilium|microtubule anchoring at centrosome|ciliary basal body|cilium assembly|vesicle targeting, trans-Golgi to periciliary membrane compartment" CEP192 1335.27676 1229.111678 1441.441841 1.172750912 0.229896623 0.495227494 1 7.604467436 9.30230369 55125 centrosomal protein 192 "GO:0000086,GO:0000242,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0009617,GO:0010389,GO:0010923,GO:0019902,GO:0051298,GO:0071539,GO:0090222,GO:0090307,GO:0097711" G2/M transition of mitotic cell cycle|pericentriolar material|protein binding|centrosome|centriole|cytosol|response to bacterium|regulation of G2/M transition of mitotic cell cycle|negative regulation of phosphatase activity|phosphatase binding|centrosome duplication|protein localization to centrosome|centrosome-templated microtubule nucleation|mitotic spindle assembly|ciliary basal body-plasma membrane docking CEP20 576.0689141 517.6275439 634.5102843 1.225804716 0.29372916 0.457728562 1 11.2226066 14.34930797 123811 centrosomal protein 20 "GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0031514,GO:0034451,GO:0034453,GO:0036064,GO:0042802,GO:0060271" protein binding|nucleoplasm|cytoplasm|centrosome|centriole|motile cilium|centriolar satellite|microtubule anchoring|ciliary basal body|identical protein binding|cilium assembly CEP250 2952.170149 2884.504862 3019.835437 1.046916397 0.066146238 0.836156537 1 13.26402718 14.48449421 11190 centrosomal protein 250 "GO:0000086,GO:0000278,GO:0001750,GO:0001917,GO:0005515,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0008022,GO:0008104,GO:0010389,GO:0010457,GO:0019901,GO:0019904,GO:0030997,GO:0032991,GO:0033365,GO:0036064,GO:0048471,GO:0050908,GO:0060271,GO:0070062,GO:0097711,GO:1904781,GO:1905515" G2/M transition of mitotic cell cycle|mitotic cell cycle|photoreceptor outer segment|photoreceptor inner segment|protein binding|centrosome|centriole|microtubule organizing center|cytosol|protein C-terminus binding|protein localization|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|protein kinase binding|protein domain specific binding|regulation of centriole-centriole cohesion|protein-containing complex|protein localization to organelle|ciliary basal body|perinuclear region of cytoplasm|detection of light stimulus involved in visual perception|cilium assembly|extracellular exosome|ciliary basal body-plasma membrane docking|positive regulation of protein localization to centrosome|non-motile cilium assembly CEP290 786.4362289 720.6187375 852.2537203 1.182669387 0.242046827 0.512388041 1 3.836114869 4.73228496 80184 centrosomal protein 290 "GO:0000086,GO:0000930,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0015031,GO:0016020,GO:0030902,GO:0030916,GO:0032391,GO:0032991,GO:0034451,GO:0035580,GO:0035869,GO:0036038,GO:0042462,GO:0042802,GO:0043312,GO:0045893,GO:0048793,GO:0051011,GO:0060271,GO:0070201,GO:0090316,GO:0097711" "G2/M transition of mitotic cell cycle|gamma-tubulin complex|protein binding|extracellular region|nucleus|cytoplasm|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|protein transport|membrane|hindbrain development|otic vesicle formation|photoreceptor connecting cilium|protein-containing complex|centriolar satellite|specific granule lumen|ciliary transition zone|MKS complex|eye photoreceptor cell development|identical protein binding|neutrophil degranulation|positive regulation of transcription, DNA-templated|pronephros development|microtubule minus-end binding|cilium assembly|regulation of establishment of protein localization|positive regulation of intracellular protein transport|ciliary basal body-plasma membrane docking" CEP295 734.5250168 606.9436691 862.1063645 1.420405893 0.506303251 0.17587209 1 3.323554511 4.924149178 85459 centrosomal protein 295 "GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005856,GO:0005886,GO:0007099,GO:0008017,GO:0010825,GO:0046599,GO:1901985,GO:1903724,GO:1904951,GO:1990498" cytoplasm|centrosome|centriole|cytosol|cytoskeleton|plasma membrane|centriole replication|microtubule binding|positive regulation of centrosome duplication|regulation of centriole replication|positive regulation of protein acetylation|positive regulation of centriole elongation|positive regulation of establishment of protein localization|mitotic spindle microtubule CEP295NL 7.463712004 5.074779842 9.852644165 1.941491941 0.957165719 0.581982097 1 0.119432944 0.241866467 100653515 CEP295 N-terminal like "GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0008017,GO:0046599" centrosome|centriole|cytosol|cilium|microtubule binding|regulation of centriole replication CEP350 1812.137564 1868.533938 1755.74119 0.939635698 -0.089826571 0.783331826 1 6.910665412 6.773221902 9857 centrosomal protein 350 "GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0008017,GO:0016020,GO:0034453,GO:0042995,GO:0071539,GO:1905515" protein binding|nucleus|cytoplasm|centrosome|centriole|spindle|microtubule binding|membrane|microtubule anchoring|cell projection|protein localization to centrosome|non-motile cilium assembly CEP41 779.0561484 788.6207874 769.4915093 0.975743376 -0.035426332 0.927125533 1 4.100704394 4.173592131 95681 centrosomal protein 41 "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0010389,GO:0015031,GO:0016020,GO:0018095,GO:0036064,GO:0060271,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|cytosol|cilium|regulation of G2/M transition of mitotic cell cycle|protein transport|membrane|protein polyglutamylation|ciliary basal body|cilium assembly|ciliary basal body-plasma membrane docking CEP43 431.9854984 467.8947014 396.0762955 0.846507332 -0.240405531 0.573260841 1 1.69799484 1.499280941 11116 centrosomal protein 43 "GO:0000086,GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0006469,GO:0008284,GO:0010389,GO:0019901,GO:0030292,GO:0030307,GO:0030335,GO:0034453,GO:0042803,GO:0042995,GO:0048471,GO:0061099,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|nucleus|centrosome|centriole|cytosol|negative regulation of protein kinase activity|positive regulation of cell population proliferation|regulation of G2/M transition of mitotic cell cycle|protein kinase binding|protein tyrosine kinase inhibitor activity|positive regulation of cell growth|positive regulation of cell migration|microtubule anchoring|protein homodimerization activity|cell projection|perinuclear region of cytoplasm|negative regulation of protein tyrosine kinase activity|ciliary basal body-plasma membrane docking CEP44 282.8112194 238.5146526 327.1077863 1.37143686 0.455688204 0.345091299 1 1.503974816 2.151455223 80817 centrosomal protein 44 "GO:0000922,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0007098,GO:0007099,GO:0008017,GO:0010457,GO:0030496" spindle pole|protein binding|cytoplasm|centrosome|centriole|centrosome cycle|centriole replication|microtubule binding|centriole-centriole cohesion|midbody CEP55 4141.606495 3640.647059 4642.565931 1.275203516 0.350727513 0.271757942 1 72.79349786 96.82511464 55165 centrosomal protein 55 "GO:0000281,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005886,GO:0006997,GO:0007080,GO:0007275,GO:0014066,GO:0016020,GO:0030496,GO:0032154,GO:0034451,GO:0042802,GO:0045171,GO:0045184,GO:0061952,GO:0090543,GO:1904888" mitotic cytokinesis|protein binding|cytoplasm|centrosome|centriole|plasma membrane|nucleus organization|mitotic metaphase plate congression|multicellular organism development|regulation of phosphatidylinositol 3-kinase signaling|membrane|midbody|cleavage furrow|centriolar satellite|identical protein binding|intercellular bridge|establishment of protein localization|midbody abscission|Flemming body|cranial skeletal system development CEP57 1289.722507 1145.885288 1433.559726 1.251049944 0.323139386 0.339771563 1 12.50485831 16.31809108 9702 centrosomal protein 57 "GO:0000086,GO:0005515,GO:0005634,GO:0005794,GO:0005813,GO:0005829,GO:0005874,GO:0007286,GO:0008017,GO:0008543,GO:0010389,GO:0017134,GO:0034453,GO:0042803,GO:0043015,GO:0051260,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|nucleus|Golgi apparatus|centrosome|cytosol|microtubule|spermatid development|microtubule binding|fibroblast growth factor receptor signaling pathway|regulation of G2/M transition of mitotic cell cycle|fibroblast growth factor binding|microtubule anchoring|protein homodimerization activity|gamma-tubulin binding|protein homooligomerization|ciliary basal body-plasma membrane docking CEP57L1 225.4634856 157.3181751 293.6087961 1.866337414 0.900209834 0.083456976 1 1.255532711 2.44418528 285753 centrosomal protein 57 like 1 "GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0005813,GO:0005874,GO:0008017,GO:0008150,GO:0042802,GO:0043015" molecular_function|protein binding|cellular_component|cytoplasm|centrosome|microtubule|microtubule binding|biological_process|identical protein binding|gamma-tubulin binding CEP63 303.229105 287.232539 319.225671 1.111384079 0.152357479 0.751434063 1 4.000911663 4.638088845 80254 centrosomal protein 63 "GO:0000077,GO:0000086,GO:0000922,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0010389,GO:0042770,GO:0051225,GO:0051301,GO:0097711,GO:0098535" DNA damage checkpoint|G2/M transition of mitotic cell cycle|spindle pole|protein binding|centrosome|centriole|cytosol|centriole replication|regulation of G2/M transition of mitotic cell cycle|signal transduction in response to DNA damage|spindle assembly|cell division|ciliary basal body-plasma membrane docking|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation CEP68 268.6315274 212.1257974 325.1372575 1.532756796 0.616128801 0.208860239 1 1.75059855 2.798825 23177 centrosomal protein 68 "GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0007098,GO:0010457,GO:0019901,GO:0019904,GO:0030054,GO:0033365,GO:0034451" protein binding|nucleoplasm|centrosome|cytosol|centrosome cycle|centriole-centriole cohesion|protein kinase binding|protein domain specific binding|cell junction|protein localization to organelle|centriolar satellite CEP70 228.0251239 231.4099608 224.640287 0.970745971 -0.042834281 0.942844137 1 1.796458944 1.819025648 80321 centrosomal protein 70 "GO:0000086,GO:0005515,GO:0005813,GO:0005829,GO:0010389,GO:0042802,GO:0043015,GO:0070507,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|centrosome|cytosol|regulation of G2/M transition of mitotic cell cycle|identical protein binding|gamma-tubulin binding|regulation of microtubule cytoskeleton organization|ciliary basal body-plasma membrane docking CEP72 335.7576765 288.247495 383.267858 1.32964853 0.411044944 0.36890797 1 5.351436491 7.422037823 55722 centrosomal protein 72 "GO:0000086,GO:0005515,GO:0005813,GO:0005829,GO:0007051,GO:0007099,GO:0010389,GO:0033566,GO:0034451,GO:0042802,GO:0097711,GO:1904779" G2/M transition of mitotic cell cycle|protein binding|centrosome|cytosol|spindle organization|centriole replication|regulation of G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|centriolar satellite|identical protein binding|ciliary basal body-plasma membrane docking|regulation of protein localization to centrosome CEP76 310.078697 317.6812181 302.4761759 0.952137422 -0.070758283 0.886381134 1 4.115997182 4.087809352 79959 centrosomal protein 76 "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0032991,GO:0046599,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|protein-containing complex|regulation of centriole replication|ciliary basal body-plasma membrane docking CEP78 935.9870955 908.3855917 963.5885994 1.060770457 0.085112502 0.813717296 1 3.945332787 4.365369274 84131 centrosomal protein 78 "GO:0000086,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0036064,GO:0044782,GO:0097711" G2/M transition of mitotic cell cycle|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|ciliary basal body|cilium organization|ciliary basal body-plasma membrane docking CEP83 238.7239773 289.262451 188.1855036 0.650570107 -0.620223562 0.223273283 1 0.860809841 0.584140418 51134 centrosomal protein 83 "GO:0003674,GO:0005515,GO:0005794,GO:0005814,GO:0005829,GO:0048278,GO:0051660,GO:0060271,GO:0071539,GO:0097539,GO:0097711" molecular_function|protein binding|Golgi apparatus|centriole|cytosol|vesicle docking|establishment of centrosome localization|cilium assembly|protein localization to centrosome|ciliary transition fiber|ciliary basal body-plasma membrane docking CEP85 676.8331085 535.8967513 817.7694657 1.525983249 0.609739126 0.109416024 1 5.876007777 9.352938055 64793 centrosomal protein 85 "GO:0000242,GO:0000922,GO:0005515,GO:0005730,GO:0005794,GO:0005813,GO:0005829,GO:0006469,GO:0007059,GO:0046602" pericentriolar material|spindle pole|protein binding|nucleolus|Golgi apparatus|centrosome|cytosol|negative regulation of protein kinase activity|chromosome segregation|regulation of mitotic centrosome separation CEP85L 157.4208578 153.2583512 161.5833643 1.054320127 0.076312984 0.906646135 1 0.799381548 0.879108635 387119 centrosomal protein 85 like "GO:0005737,GO:0005813" cytoplasm|centrosome CEP89 415.0660189 355.2345889 474.8974488 1.336855879 0.418843943 0.329641555 1 3.030382135 4.225692758 84902 centrosomal protein 89 "GO:0000922,GO:0005515,GO:0005758,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0007005,GO:0007268,GO:0031514,GO:0045202,GO:0060271,GO:0097539,GO:0097711,GO:0097730,GO:1905515" spindle pole|protein binding|mitochondrial intermembrane space|centrosome|centriole|cytosol|plasma membrane|mitochondrion organization|chemical synaptic transmission|motile cilium|synapse|cilium assembly|ciliary transition fiber|ciliary basal body-plasma membrane docking|non-motile cilium|non-motile cilium assembly CEP95 611.0970191 622.1680086 600.0260297 0.964411576 -0.052279127 0.897235991 1 5.179259494 5.210099474 90799 centrosomal protein 95 "GO:0000922,GO:0005515,GO:0005737,GO:0005813" spindle pole|protein binding|cytoplasm|centrosome CEP97 796.5669835 604.9137572 988.2202098 1.633654712 0.708103089 0.054673531 1 3.657245767 6.232041626 79598 centrosomal protein 97 "GO:0005515,GO:0005516,GO:0005813,GO:0005829,GO:0032991,GO:0034451,GO:0097711,GO:1901673,GO:1902018" protein binding|calmodulin binding|centrosome|cytosol|protein-containing complex|centriolar satellite|ciliary basal body-plasma membrane docking|regulation of mitotic spindle assembly|negative regulation of cilium assembly CEPT1 516.7006709 500.3732924 533.0280494 1.065260791 0.091206666 0.825939501 1 9.473697962 10.52667965 10390 choline/ethanolamine phosphotransferase 1 "GO:0004142,GO:0004307,GO:0005515,GO:0005789,GO:0005794,GO:0006629,GO:0006646,GO:0006656,GO:0006657,GO:0016021,GO:0031965,GO:0046872" diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|lipid metabolic process|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|CDP-choline pathway|integral component of membrane|nuclear membrane|metal ion binding "hsa00440,hsa00564,hsa00565" Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Ether lipid metabolism CERCAM 2395.56627 2384.13157 2407.00097 1.00959234 0.013772869 0.967019403 1 21.19498917 22.32005063 51148 cerebral endothelial cell adhesion molecule "GO:0005515,GO:0005788,GO:0005886,GO:0007155,GO:0007159,GO:0018215,GO:0042802,GO:0050211" protein binding|endoplasmic reticulum lumen|plasma membrane|cell adhesion|leukocyte cell-cell adhesion|protein phosphopantetheinylation|identical protein binding|procollagen galactosyltransferase activity CERK 1771.193913 1629.004329 1913.383497 1.174572383 0.232135622 0.476088115 1 18.38309325 22.52238122 64781 ceramide kinase "GO:0000287,GO:0001727,GO:0001729,GO:0003951,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006665,GO:0006672,GO:0006687,GO:0016021,GO:0016310,GO:0046834,GO:0102773" magnesium ion binding|lipid kinase activity|ceramide kinase activity|NAD+ kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|sphingolipid metabolic process|ceramide metabolic process|glycosphingolipid metabolic process|integral component of membrane|phosphorylation|lipid phosphorylation|dihydroceramide kinase activity hsa00600 Sphingolipid metabolism CERS1 63.69256942 77.1366536 50.24848524 0.651421638 -0.618336453 0.435389056 1 0.80616991 0.547778136 10715 ceramide synthase 1 "GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0016410,GO:0030148,GO:0035690,GO:0036146,GO:0043231,GO:0046513,GO:0050291,GO:0051974,GO:0071492,GO:0072721" endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|N-acyltransferase activity|sphingolipid biosynthetic process|cellular response to drug|cellular response to mycotoxin|intracellular membrane-bounded organelle|ceramide biosynthetic process|sphingosine N-acyltransferase activity|negative regulation of telomerase activity|cellular response to UV-A|cellular response to dithiothreitol "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway CERS2 4325.688875 3797.965234 4853.412516 1.277898089 0.353772788 0.268192185 1 73.75519197 98.3115964 29956 ceramide synthase 2 "GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0016410,GO:0030148,GO:0046513,GO:0048681,GO:0050291,GO:1900148,GO:1905045" DNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|N-acyltransferase activity|sphingolipid biosynthetic process|ceramide biosynthetic process|negative regulation of axon regeneration|sphingosine N-acyltransferase activity|negative regulation of Schwann cell migration|negative regulation of Schwann cell proliferation involved in axon regeneration "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway CERS4 152.4175852 181.6771183 123.1580521 0.677895231 -0.560865774 0.342405213 1 3.486663556 2.46540658 79603 ceramide synthase 4 "GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0016410,GO:0030148,GO:0046513,GO:0050291" DNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|N-acyltransferase activity|sphingolipid biosynthetic process|ceramide biosynthetic process|sphingosine N-acyltransferase activity "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway CERS5 941.8771553 805.8750389 1077.879272 1.337526564 0.419567544 0.238910541 1 11.50683049 16.05366002 91012 ceramide synthase 5 "GO:0003677,GO:0005783,GO:0005789,GO:0016021,GO:0016410,GO:0030148,GO:0046513,GO:0050291" DNA binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|N-acyltransferase activity|sphingolipid biosynthetic process|ceramide biosynthetic process|sphingosine N-acyltransferase activity "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway CERS6 1284.638325 1067.733679 1501.542971 1.40628979 0.491893917 0.146541867 1 5.210226813 7.642710039 253782 ceramide synthase 6 "GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0006954,GO:0016020,GO:0016021,GO:0016410,GO:0030148,GO:0046513,GO:0050291" DNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|inflammatory response|membrane|integral component of membrane|N-acyltransferase activity|sphingolipid biosynthetic process|ceramide biosynthetic process|sphingosine N-acyltransferase activity "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway CERT1 1186.802708 1384.399941 989.2054742 0.714537357 -0.484918656 0.157208297 1 7.156779946 5.334067813 10087 ceramide transporter 1 "GO:0000902,GO:0001701,GO:0003007,GO:0005515,GO:0005654,GO:0005739,GO:0005789,GO:0005794,GO:0005829,GO:0006672,GO:0006936,GO:0006955,GO:0007029,GO:0007165,GO:0008283,GO:0016020,GO:0016301,GO:0016310,GO:0030148,GO:0034976,GO:0035621,GO:0035627,GO:0048471,GO:0055088,GO:0070273,GO:0070584,GO:0097001,GO:0120009,GO:0120012,GO:0120017,GO:1902387,GO:1902388,GO:1902389" cell morphogenesis|in utero embryonic development|heart morphogenesis|protein binding|nucleoplasm|mitochondrion|endoplasmic reticulum membrane|Golgi apparatus|cytosol|ceramide metabolic process|muscle contraction|immune response|endoplasmic reticulum organization|signal transduction|cell population proliferation|membrane|kinase activity|phosphorylation|sphingolipid biosynthetic process|response to endoplasmic reticulum stress|ER to Golgi ceramide transport|ceramide transport|perinuclear region of cytoplasm|lipid homeostasis|phosphatidylinositol-4-phosphate binding|mitochondrion morphogenesis|ceramide binding|intermembrane lipid transfer|intermembrane sphingolipid transfer|ceramide transfer activity|ceramide 1-phosphate binding|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport CES2 825.3702569 890.1163843 760.6241296 0.854522109 -0.226810276 0.5354494 1 11.65492625 10.38840237 8824 carboxylesterase 2 "GO:0004771,GO:0004806,GO:0005615,GO:0005783,GO:0005788,GO:0006693,GO:0006805,GO:0009056,GO:0016042,GO:0047374,GO:0052689,GO:0080030" sterol esterase activity|triglyceride lipase activity|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|prostaglandin metabolic process|xenobiotic metabolic process|catabolic process|lipid catabolic process|methylumbelliferyl-acetate deacetylase activity|carboxylic ester hydrolase activity|methyl indole-3-acetate esterase activity hsa00983 Drug metabolism - other enzymes CES3 11.55322743 15.22433953 7.882115332 0.517731184 -0.949724877 0.496050235 1 0.180027805 0.097220946 23491 carboxylesterase 3 "GO:0004771,GO:0004806,GO:0005615,GO:0005788,GO:0005829,GO:0006805,GO:0016042,GO:0034383,GO:0052689,GO:0070062,GO:0080030" sterol esterase activity|triglyceride lipase activity|extracellular space|endoplasmic reticulum lumen|cytosol|xenobiotic metabolic process|lipid catabolic process|low-density lipoprotein particle clearance|carboxylic ester hydrolase activity|extracellular exosome|methyl indole-3-acetate esterase activity CES5A 5.56741205 10.14955968 0.985264417 0.097074597 -3.364762376 0.106651607 1 0.207023517 0.02096241 221223 carboxylesterase 5A "GO:0004771,GO:0004806,GO:0005615,GO:0016042,GO:0052689,GO:0080030" sterol esterase activity|triglyceride lipase activity|extracellular space|lipid catabolic process|carboxylic ester hydrolase activity|methyl indole-3-acetate esterase activity CETN2 1152.479281 1058.599075 1246.359487 1.177366877 0.235563946 0.49433386 1 37.9436013 46.59789426 1069 centrin 2 "GO:0000086,GO:0000278,GO:0000715,GO:0000717,GO:0005509,GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0006289,GO:0006294,GO:0007099,GO:0007283,GO:0008017,GO:0010389,GO:0015031,GO:0031683,GO:0032391,GO:0032465,GO:0032795,GO:0036064,GO:0044615,GO:0045177,GO:0051028,GO:0051301,GO:0070390,GO:0070911,GO:0071942,GO:0097711,GO:0097729" "G2/M transition of mitotic cell cycle|mitotic cell cycle|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|calcium ion binding|protein binding|nucleoplasm|centrosome|centriole|cytosol|nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|centriole replication|spermatogenesis|microtubule binding|regulation of G2/M transition of mitotic cell cycle|protein transport|G-protein beta/gamma-subunit complex binding|photoreceptor connecting cilium|regulation of cytokinesis|heterotrimeric G-protein binding|ciliary basal body|nuclear pore nuclear basket|apical part of cell|mRNA transport|cell division|transcription export complex 2|global genome nucleotide-excision repair|XPC complex|ciliary basal body-plasma membrane docking|9+2 motile cilium" hsa03420 Nucleotide excision repair CETN3 400.8539137 360.3093688 441.3984586 1.22505407 0.292845426 0.500874509 1 7.364164017 9.410108693 1070 centrin 3 "GO:0005509,GO:0005515,GO:0005730,GO:0005737,GO:0005813,GO:0005814,GO:0005815,GO:0007098,GO:0008017,GO:0015031,GO:0044615,GO:0051028,GO:0051301,GO:0070390" calcium ion binding|protein binding|nucleolus|cytoplasm|centrosome|centriole|microtubule organizing center|centrosome cycle|microtubule binding|protein transport|nuclear pore nuclear basket|mRNA transport|cell division|transcription export complex 2 CFAP161 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.075631102 0 161502 cilia and flagella associated protein 161 GO:0005515 protein binding CFAP20 550.3453972 544.016399 556.6743953 1.023267674 0.033183586 0.938480519 1 21.50859597 22.95711163 29105 cilia and flagella associated protein 20 "GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005814,GO:0005874,GO:0005929,GO:0007275,GO:0018095,GO:0031514,GO:0036064,GO:0060271,GO:0060296,GO:0070062,GO:2000147,GO:2000253" RNA binding|protein binding|nucleoplasm|cytoplasm|centriole|microtubule|cilium|multicellular organism development|protein polyglutamylation|motile cilium|ciliary basal body|cilium assembly|regulation of cilium beat frequency involved in ciliary motility|extracellular exosome|positive regulation of cell motility|positive regulation of feeding behavior CFAP206 17.1057937 24.35894324 9.852644165 0.404477488 -1.305868687 0.270147201 1 0.558991637 0.235838984 154313 cilia and flagella associated protein 206 "GO:0001534,GO:0003341,GO:0003356,GO:0005515,GO:0005930,GO:0007288,GO:0031514,GO:0035082,GO:0036064,GO:0097649,GO:1901317" radial spoke|cilium movement|regulation of cilium beat frequency|protein binding|axoneme|sperm axoneme assembly|motile cilium|axoneme assembly|ciliary basal body|A axonemal microtubule|regulation of flagellated sperm motility CFAP20DC 300.9198449 230.3950048 371.444685 1.612208066 0.689037945 0.145188961 1 1.841068824 3.096043423 200844 CFAP20 domain containing CFAP251 187.5901887 161.377999 213.8023784 1.324854564 0.405833996 0.463257768 1 1.921303794 2.65509568 144406 cilia and flagella associated protein 251 "GO:0001536,GO:0003341,GO:0005930,GO:0030317,GO:0031514,GO:0036126" radial spoke stalk|cilium movement|axoneme|flagellated sperm motility|motile cilium|sperm flagellum CFAP298 97.62208708 106.5703767 88.67379749 0.832067975 -0.265226703 0.707207924 1 1.171567966 1.016815657 56683 cilia and flagella associated protein 298 "GO:0003352,GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0005929,GO:0060271" regulation of cilium movement|protein binding|nucleus|cytosol|cytoskeleton|cilium|cilium assembly CFAP300 55.09513524 61.91231407 48.27795641 0.77977955 -0.358861775 0.675141325 1 2.500510601 2.033838534 85016 cilia and flagella associated protein 300 "GO:0005515,GO:0005737,GO:0005856,GO:0031514" protein binding|cytoplasm|cytoskeleton|motile cilium CFAP36 459.3083997 416.131947 502.4848524 1.20751328 0.272039056 0.516346639 1 8.447140317 10.63941022 112942 cilia and flagella associated protein 36 "GO:0005515,GO:0005634,GO:0005930,GO:0008150,GO:0031514,GO:0035869,GO:0047485,GO:0097546" protein binding|nucleus|axoneme|biological_process|motile cilium|ciliary transition zone|protein N-terminus binding|ciliary base CFAP410 186.379516 179.6472064 193.1118256 1.07495034 0.104270013 0.858844793 1 3.415351819 3.829479762 755 cilia and flagella associated protein 410 "GO:0001750,GO:0003674,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0007010,GO:0008360,GO:0032391,GO:0036064,GO:0042769,GO:0043231,GO:0060271" "photoreceptor outer segment|molecular_function|protein binding|cytoplasm|mitochondrion|cytosol|plasma membrane|cytoskeleton organization|regulation of cell shape|photoreceptor connecting cilium|ciliary basal body|DNA damage response, detection of DNA damage|intracellular membrane-bounded organelle|cilium assembly" CFAP43 43.4231416 38.5683268 48.27795641 1.251751383 0.323948049 0.731900879 1 0.350502367 0.457641041 80217 cilia and flagella associated protein 43 "GO:0003356,GO:0005576,GO:0005930,GO:0007288,GO:0007420,GO:0044458,GO:0060271,GO:0090660,GO:0097729,GO:0120197" regulation of cilium beat frequency|extracellular region|axoneme|sperm axoneme assembly|brain development|motile cilium assembly|cilium assembly|cerebrospinal fluid circulation|9+2 motile cilium|mucociliary clearance CFAP44 225.9924903 260.8436839 191.1412968 0.732781005 -0.448545988 0.387774667 1 1.253516689 0.958120767 55779 cilia and flagella associated protein 44 "GO:0000226,GO:0005515,GO:0005737,GO:0005856,GO:0006508,GO:0007288,GO:0008233,GO:0031514,GO:0060271,GO:0060285" microtubule cytoskeleton organization|protein binding|cytoplasm|cytoskeleton|proteolysis|sperm axoneme assembly|peptidase activity|motile cilium|cilium assembly|cilium-dependent cell motility CFAP45 14.0609258 18.26920743 9.852644165 0.539303317 -0.890831188 0.491533239 1 0.50177381 0.282264988 25790 cilia and flagella associated protein 45 "GO:0005515,GO:0005634,GO:0005654,GO:0005929" protein binding|nucleus|nucleoplasm|cilium CFAP52 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.122041641 0.07414482 146845 cilia and flagella associated protein 52 "GO:0005515,GO:0005737,GO:0031514,GO:0060271" protein binding|cytoplasm|motile cilium|cilium assembly CFAP53 24.95821748 22.3290313 27.58740366 1.235494872 0.305089022 0.800256453 1 0.592397414 0.763431422 220136 cilia and flagella associated protein 53 "GO:0003341,GO:0005515,GO:0005575,GO:0005576,GO:0005929,GO:0007368,GO:0060271,GO:0060287" cilium movement|protein binding|cellular_component|extracellular region|cilium|determination of left/right symmetry|cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry CFAP54 26.07709388 31.46363502 20.69055275 0.657602109 -0.604713169 0.571512629 1 0.159815677 0.109622198 144535 cilia and flagella associated protein 54 "GO:0005930,GO:0007283,GO:0030154,GO:0060271,GO:0060294" axoneme|spermatogenesis|cell differentiation|cilium assembly|cilium movement involved in cell motility CFAP57 5.508028946 6.08973581 4.926322083 0.808954975 -0.305868687 0.976518791 1 0.064014868 0.05401584 149465 cilia and flagella associated protein 57 CFAP58 11.94193921 8.119647747 15.76423066 1.941491941 0.957165719 0.487279695 1 0.126299605 0.255772303 159686 cilia and flagella associated protein 58 "GO:0005515,GO:0005615,GO:0005856,GO:0005929" protein binding|extracellular space|cytoskeleton|cilium CFAP61 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.015881753 0.010720837 26074 cilia and flagella associated protein 61 "GO:0001536,GO:0003341,GO:0005930,GO:0031514,GO:0044782" radial spoke stalk|cilium movement|axoneme|motile cilium|cilium organization CFAP69 57.30591809 44.65806261 69.95377357 1.566430998 0.64748122 0.430175602 1 0.359068634 0.586684573 79846 cilia and flagella associated protein 69 "GO:0005737,GO:0007288,GO:0007608,GO:0030317,GO:0042048,GO:0097225,GO:0097730,GO:1902093,GO:1905516,GO:1990834" cytoplasm|sperm axoneme assembly|sensory perception of smell|flagellated sperm motility|olfactory behavior|sperm midpiece|non-motile cilium|positive regulation of flagellated sperm motility|positive regulation of fertilization|response to odorant CFAP70 32.51100414 33.49354696 31.52846133 0.941329426 -0.087228401 0.962507373 1 0.265840777 0.261023231 118491 cilia and flagella associated protein 70 "GO:0003341,GO:0003674,GO:0005930,GO:0008150,GO:0036064,GO:0036126,GO:0036157,GO:0060271,GO:0070062" cilium movement|molecular_function|axoneme|biological_process|ciliary basal body|sperm flagellum|outer dynein arm|cilium assembly|extracellular exosome CFAP73 8.478667972 7.104691779 9.852644165 1.386779958 0.471738892 0.817532793 1 0.133417714 0.192990967 387885 cilia and flagella associated protein 73 "GO:0003341,GO:0031514,GO:0036159,GO:0070840,GO:0097545,GO:2000574" cilium movement|motile cilium|inner dynein arm assembly|dynein complex binding|axonemal outer doublet|regulation of microtubule motor activity CFAP77 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.068220225 0.017269298 389799 cilia and flagella associated protein 77 "GO:0005515,GO:0005929" protein binding|cilium CFAP91 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.081170218 0.046965634 89876 cilia and flagella associated protein 91 "GO:0001536,GO:0003341,GO:0005515,GO:0005739,GO:0005930,GO:0031514" radial spoke stalk|cilium movement|protein binding|mitochondrion|axoneme|motile cilium CFAP92 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.014934323 0.015121924 57501 cilia and flagella associated protein 92 (putative) CFAP97 640.4943697 577.509946 703.4787934 1.218124118 0.28466114 0.460738874 1 3.850051525 4.89185993 57587 cilia and flagella associated protein 97 CFAP97D1 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.027335251 0.05535726 284067 CFAP97 domain containing 1 "GO:0005515,GO:0007288" protein binding|sperm axoneme assembly CFB 447.8630521 543.0014431 352.7246611 0.649583285 -0.622413585 0.139011471 1 11.10707088 7.525759131 629 complement factor B "GO:0001848,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0006508,GO:0006956,GO:0006957,GO:0030449,GO:0070062,GO:0072562" "complement binding|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|plasma membrane|proteolysis|complement activation|complement activation, alternative pathway|regulation of complement activation|extracellular exosome|blood microparticle" "hsa04610,hsa05150,hsa05171" Complement and coagulation cascades|Staphylococcus aureus infection|Coronavirus disease - COVID-19 CFD 53.36213882 78.15160956 28.57266808 0.365605625 -1.451639827 0.083951994 1 3.323344519 1.267372164 1675 complement factor D "GO:0002576,GO:0004252,GO:0005576,GO:0006508,GO:0006956,GO:0006957,GO:0007219,GO:0008236,GO:0031093,GO:0034774,GO:0043312,GO:0070062,GO:1904813" "platelet degranulation|serine-type endopeptidase activity|extracellular region|proteolysis|complement activation|complement activation, alternative pathway|Notch signaling pathway|serine-type peptidase activity|platelet alpha granule lumen|secretory granule lumen|neutrophil degranulation|extracellular exosome|ficolin-1-rich granule lumen" "hsa04610,hsa05150,hsa05171" Complement and coagulation cascades|Staphylococcus aureus infection|Coronavirus disease - COVID-19 CFDP1 549.5328389 623.1829646 475.8827132 0.763632417 -0.389049748 0.330112913 1 17.90244963 14.25977741 10428 craniofacial development protein 1 "GO:0000777,GO:0003674,GO:0005575,GO:0007155,GO:0007275,GO:0008150,GO:0008360,GO:0042127,GO:2000270" condensed chromosome kinetochore|molecular_function|cellular_component|cell adhesion|multicellular organism development|biological_process|regulation of cell shape|regulation of cell population proliferation|negative regulation of fibroblast apoptotic process CFH 25.03244636 27.40381115 22.66108158 0.826931753 -0.274159827 0.824255662 1 0.327259222 0.282278299 3075 complement factor H "GO:0005515,GO:0005576,GO:0005615,GO:0006956,GO:0006957,GO:0008201,GO:0016032,GO:0030449,GO:0042802,GO:0043395,GO:0070062,GO:0072562,GO:1903659" "protein binding|extracellular region|extracellular space|complement activation|complement activation, alternative pathway|heparin binding|viral process|regulation of complement activation|identical protein binding|heparan sulfate proteoglycan binding|extracellular exosome|blood microparticle|regulation of complement-dependent cytotoxicity" "hsa04610,hsa05150" Complement and coagulation cascades|Staphylococcus aureus infection CFHR3 10.47888836 9.134603715 11.823173 1.294327961 0.372203218 0.848192439 1 0.157680795 0.21288206 10878 complement factor H related 3 "GO:0005515,GO:0005615,GO:0070062,GO:0072562" protein binding|extracellular space|extracellular exosome|blood microparticle hsa04610 Complement and coagulation cascades CFI 35.97427538 34.50850292 37.44004783 1.084951379 0.117630391 0.930591207 1 0.638791643 0.722911996 3426 complement factor I "GO:0004252,GO:0005044,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0006897,GO:0006958,GO:0016020,GO:0016032,GO:0030449,GO:0045087,GO:0046872,GO:0070062" "serine-type endopeptidase activity|scavenger receptor activity|protein binding|extracellular region|extracellular space|proteolysis|endocytosis|complement activation, classical pathway|membrane|viral process|regulation of complement activation|innate immune response|metal ion binding|extracellular exosome" "hsa04610,hsa05150" Complement and coagulation cascades|Staphylococcus aureus infection CFL1 23195.85533 23526.67935 22865.03131 0.971876693 -0.041154812 0.911993444 1 957.062901 970.2140929 1072 cofilin 1 "GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0007010,GO:0007266,GO:0009615,GO:0015629,GO:0016020,GO:0016032,GO:0016363,GO:0022604,GO:0030027,GO:0030036,GO:0030042,GO:0030043,GO:0031258,GO:0031982,GO:0032587,GO:0035722,GO:0040019,GO:0043066,GO:0044794,GO:0048870,GO:0051014,GO:0051015,GO:0051293,GO:0061001,GO:0070062" protein binding|extracellular space|nucleus|cytoplasm|cytosol|focal adhesion|cytoskeleton organization|Rho protein signal transduction|response to virus|actin cytoskeleton|membrane|viral process|nuclear matrix|regulation of cell morphogenesis|lamellipodium|actin cytoskeleton organization|actin filament depolymerization|actin filament fragmentation|lamellipodium membrane|vesicle|ruffle membrane|interleukin-12-mediated signaling pathway|positive regulation of embryonic development|negative regulation of apoptotic process|positive regulation by host of viral process|cell motility|actin filament severing|actin filament binding|establishment of spindle localization|regulation of dendritic spine morphogenesis|extracellular exosome "hsa04360,hsa04666,hsa04810,hsa05133,hsa05170" Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Pertussis|Human immunodeficiency virus 1 infection CFL2 1561.055966 1542.733072 1579.37886 1.02375381 0.033868821 0.920168835 1 17.08967359 18.24925873 1073 cofilin 2 "GO:0005515,GO:0005615,GO:0005737,GO:0007519,GO:0015629,GO:0016363,GO:0030018,GO:0030042,GO:0030043,GO:0030836,GO:0031674,GO:0045214,GO:0046716,GO:0048870,GO:0051014,GO:0051015,GO:0070062" protein binding|extracellular space|cytoplasm|skeletal muscle tissue development|actin cytoskeleton|nuclear matrix|Z disc|actin filament depolymerization|actin filament fragmentation|positive regulation of actin filament depolymerization|I band|sarcomere organization|muscle cell cellular homeostasis|cell motility|actin filament severing|actin filament binding|extracellular exosome "hsa04360,hsa04666,hsa04810,hsa05133,hsa05170" Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Pertussis|Human immunodeficiency virus 1 infection CFLAR 1636.428694 1542.733072 1730.124315 1.121467055 0.16538724 0.615014927 1 4.11795023 4.817076498 8837 CASP8 and FADD like apoptosis regulator "GO:0002020,GO:0005123,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0006919,GO:0007519,GO:0008047,GO:0010667,GO:0010976,GO:0014732,GO:0014842,GO:0014866,GO:0016032,GO:0031264,GO:0031265,GO:0032869,GO:0033574,GO:0042060,GO:0043066,GO:0043123,GO:0043403,GO:0044877,GO:0045121,GO:0051092,GO:0060544,GO:0070374,GO:0071364,GO:0071392,GO:0071456,GO:0071549,GO:0071732,GO:0072126,GO:0097153,GO:0097190,GO:0097194,GO:0097199,GO:0097200,GO:0097342,GO:1901740,GO:1902041,GO:1902042,GO:1903055,GO:1903427,GO:1903845,GO:1903944,GO:2000347,GO:2001237" protease binding|death receptor binding|protein binding|cytoplasm|cytosol|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|skeletal muscle tissue development|enzyme activator activity|negative regulation of cardiac muscle cell apoptotic process|positive regulation of neuron projection development|skeletal muscle atrophy|regulation of skeletal muscle satellite cell proliferation|skeletal myofibril assembly|viral process|death-inducing signaling complex|CD95 death-inducing signaling complex|cellular response to insulin stimulus|response to testosterone|wound healing|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|skeletal muscle tissue regeneration|protein-containing complex binding|membrane raft|positive regulation of NF-kappaB transcription factor activity|regulation of necroptotic process|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|cellular response to estradiol stimulus|cellular response to hypoxia|cellular response to dexamethasone stimulus|cellular response to nitric oxide|positive regulation of glomerular mesangial cell proliferation|cysteine-type endopeptidase activity involved in apoptotic process|apoptotic signaling pathway|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|ripoptosome|negative regulation of myoblast fusion|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of extracellular matrix organization|negative regulation of reactive oxygen species biosynthetic process|negative regulation of cellular response to transforming growth factor beta stimulus|negative regulation of hepatocyte apoptotic process|positive regulation of hepatocyte proliferation|negative regulation of extrinsic apoptotic signaling pathway "hsa04064,hsa04140,hsa04210,hsa04217,hsa04668,hsa05142,hsa05160" NF-kappa B signaling pathway|Autophagy - animal|Apoptosis|Necroptosis|TNF signaling pathway|Chagas disease|Hepatitis C CFP 8.075110419 13.19442759 2.95579325 0.224018301 -2.158311499 0.176784179 1 0.184599782 0.04313508 5199 complement factor properdin "GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006955,GO:0006956,GO:0006957,GO:0030449,GO:0035580,GO:0042742,GO:0043312,GO:0062023,GO:1904724" "protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|immune response|complement activation|complement activation, alternative pathway|regulation of complement activation|specific granule lumen|defense response to bacterium|neutrophil degranulation|collagen-containing extracellular matrix|tertiary granule lumen" hsa05168 Herpes simplex virus 1 infection CGAS 404.1511598 383.653356 424.6489635 1.106855855 0.146467354 0.738707648 1 6.070193388 7.008249003 115004 cyclic GMP-AMP synthase "GO:0002218,GO:0002230,GO:0002637,GO:0003677,GO:0003682,GO:0003690,GO:0005515,GO:0005524,GO:0005525,GO:0005546,GO:0005634,GO:0005829,GO:0005886,GO:0006281,GO:0006974,GO:0008340,GO:0010753,GO:0016032,GO:0032481,GO:0035861,GO:0038001,GO:0043950,GO:0045087,GO:0046872,GO:0050863,GO:0051607,GO:0061501,GO:0071360,GO:2000042,GO:2000774" "activation of innate immune response|positive regulation of defense response to virus by host|regulation of immunoglobulin production|DNA binding|chromatin binding|double-stranded DNA binding|protein binding|ATP binding|GTP binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytosol|plasma membrane|DNA repair|cellular response to DNA damage stimulus|determination of adult lifespan|positive regulation of cGMP-mediated signaling|viral process|positive regulation of type I interferon production|site of double-strand break|paracrine signaling|positive regulation of cAMP-mediated signaling|innate immune response|metal ion binding|regulation of T cell activation|defense response to virus|cyclic-GMP-AMP synthase activity|cellular response to exogenous dsRNA|negative regulation of double-strand break repair via homologous recombination|positive regulation of cellular senescence" "hsa04623,hsa05131,hsa05163,hsa05168,hsa05170,hsa05171" Cytosolic DNA-sensing pathway|Shigellosis|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 CGB7 9.523315492 11.16451565 7.882115332 0.705997069 -0.5022659 0.780585832 1 0.262874631 0.193583129 94027 chorionic gonadotropin subunit beta 7 "GO:0005179,GO:0005615,GO:0005737,GO:0006915,GO:0007165,GO:0007186,GO:0007267,GO:0007292,GO:0009755" hormone activity|extracellular space|cytoplasm|apoptotic process|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|female gamete generation|hormone-mediated signaling pathway CGGBP1 2853.608819 2579.003116 3128.214523 1.212954922 0.278525935 0.381690738 1 27.42910744 34.70341921 8545 CGG triplet repeat binding protein 1 "GO:0000122,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0010468,GO:0042802,GO:0090579" negative regulation of transcription by RNA polymerase II|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|regulation of gene expression|identical protein binding|dsDNA loop formation CGN 98.50070947 132.9592319 64.04218708 0.481667848 -1.05388947 0.123252924 1 1.284118238 0.645161736 57530 cingulin "GO:0003774,GO:0003779,GO:0005515,GO:0005886,GO:0005923,GO:0007179,GO:0008150,GO:0016459,GO:0030054,GO:0045296" motor activity|actin binding|protein binding|plasma membrane|bicellular tight junction|transforming growth factor beta receptor signaling pathway|biological_process|myosin complex|cell junction|cadherin binding hsa04530 Tight junction CGNL1 36.57082802 41.6131947 31.52846133 0.757655392 -0.400386286 0.684410473 1 0.238925463 0.188820909 84952 cingulin like 1 "GO:0003774,GO:0005515,GO:0005923,GO:0007015,GO:0016459,GO:0032991,GO:0051058,GO:0051497,GO:0150105" motor activity|protein binding|bicellular tight junction|actin filament organization|myosin complex|protein-containing complex|negative regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|protein localization to cell-cell junction hsa04530 Tight junction CGREF1 55.73622521 72.06187375 39.41057666 0.546899138 -0.870653306 0.290187954 1 1.352234045 0.77139183 10669 cell growth regulator with EF-hand domain 1 "GO:0005509,GO:0005576,GO:0007050,GO:0007155,GO:0008285" calcium ion binding|extracellular region|cell cycle arrest|cell adhesion|negative regulation of cell population proliferation CGRRF1 210.7114893 192.841634 228.5813446 1.185331922 0.245291106 0.648172009 1 4.387577923 5.424762794 10668 cell growth regulator with ring finger domain 1 "GO:0005515,GO:0005654,GO:0005783,GO:0007050,GO:0008285,GO:0030308,GO:0043231,GO:0046872" protein binding|nucleoplasm|endoplasmic reticulum|cell cycle arrest|negative regulation of cell population proliferation|negative regulation of cell growth|intracellular membrane-bounded organelle|metal ion binding CH25H 15.16495642 26.38885518 3.941057666 0.149345534 -2.743273999 0.036264992 0.859328149 0.791298058 0.12326741 9023 cholesterol 25-hydroxylase "GO:0000254,GO:0001567,GO:0005506,GO:0005515,GO:0005789,GO:0005829,GO:0006629,GO:0006699,GO:0008203,GO:0008395,GO:0016020,GO:0016021,GO:0016126,GO:0016491,GO:0035754,GO:0055114" C-4 methylsterol oxidase activity|cholesterol 25-hydroxylase activity|iron ion binding|protein binding|endoplasmic reticulum membrane|cytosol|lipid metabolic process|bile acid biosynthetic process|cholesterol metabolic process|steroid hydroxylase activity|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity|B cell chemotaxis|oxidation-reduction process hsa00120 Primary bile acid biosynthesis CHAC1 52.21629247 33.49354696 70.93903799 2.117991208 1.082696601 0.197962648 1 0.455757656 1.006871517 79094 ChaC glutathione specific gamma-glutamylcyclotransferase 1 "GO:0003839,GO:0005112,GO:0005515,GO:0005737,GO:0005802,GO:0005829,GO:0006750,GO:0006751,GO:0006986,GO:0007219,GO:0010955,GO:0022008,GO:0045746,GO:0061928,GO:0070059" gamma-glutamylcyclotransferase activity|Notch binding|protein binding|cytoplasm|trans-Golgi network|cytosol|glutathione biosynthetic process|glutathione catabolic process|response to unfolded protein|Notch signaling pathway|negative regulation of protein processing|neurogenesis|negative regulation of Notch signaling pathway|glutathione specific gamma-glutamylcyclotransferase activity|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress hsa00480 Glutathione metabolism CHAC2 79.23139184 95.40586103 63.05692266 0.660933427 -0.597423133 0.417552042 1 3.633060368 2.504645472 494143 ChaC glutathione specific gamma-glutamylcyclotransferase 2 "GO:0003674,GO:0003839,GO:0005575,GO:0005737,GO:0005829,GO:0006750,GO:0006751,GO:0008150,GO:0061928" molecular_function|gamma-glutamylcyclotransferase activity|cellular_component|cytoplasm|cytosol|glutathione biosynthetic process|glutathione catabolic process|biological_process|glutathione specific gamma-glutamylcyclotransferase activity hsa00480 Glutathione metabolism CHADL 7.045308675 10.14955968 3.941057666 0.388298388 -1.364762376 0.421596647 1 0.202936989 0.082194495 150356 chondroadherin like "GO:0005518,GO:0005615,GO:0030021,GO:0031012,GO:0032331,GO:0062023,GO:0098633,GO:1904027" collagen binding|extracellular space|extracellular matrix structural constituent conferring compression resistance|extracellular matrix|negative regulation of chondrocyte differentiation|collagen-containing extracellular matrix|collagen fibril binding|negative regulation of collagen fibril organization CHAF1A 1131.414862 1066.718723 1196.111002 1.121299342 0.165171471 0.633486299 1 12.49723344 14.61676885 10036 chromatin assembly factor 1 subunit A "GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0006260,GO:0006281,GO:0006334,GO:0006335,GO:0007049,GO:0031497,GO:0032991,GO:0033186,GO:0042802,GO:0051082,GO:0070087" chromatin|chromatin binding|protein binding|nucleus|DNA replication|DNA repair|nucleosome assembly|DNA replication-dependent nucleosome assembly|cell cycle|chromatin assembly|protein-containing complex|CAF-1 complex|identical protein binding|unfolded protein binding|chromo shadow domain binding CHAF1B 698.8800701 561.2706505 836.4894896 1.4903496 0.575650792 0.127947949 1 4.732208824 7.356444896 8208 chromatin assembly factor 1 subunit B "GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006260,GO:0006281,GO:0006334,GO:0006335,GO:0007049,GO:0031497,GO:0032991,GO:0033186,GO:0042393,GO:0051082" chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA replication|DNA repair|nucleosome assembly|DNA replication-dependent nucleosome assembly|cell cycle|chromatin assembly|protein-containing complex|CAF-1 complex|histone binding|unfolded protein binding CHAMP1 565.0177214 570.4052542 559.6301886 0.981109806 -0.027513482 0.949424452 1 7.604373219 7.782102918 283489 chromosome alignment maintaining phosphoprotein 1 "GO:0000777,GO:0000793,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0016604,GO:0031134,GO:0034501,GO:0035372,GO:0046872,GO:0051315,GO:0090543" condensed chromosome kinetochore|condensed chromosome|protein binding|nucleus|nucleoplasm|cytoplasm|spindle|nuclear body|sister chromatid biorientation|protein localization to kinetochore|protein localization to microtubule|metal ion binding|attachment of mitotic spindle microtubules to kinetochore|Flemming body CHCHD1 644.4272626 677.9905869 610.8639383 0.900991769 -0.150414168 0.698133667 1 40.39744873 37.96563706 118487 coiled-coil-helix-coiled-coil-helix domain containing 1 "GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005761,GO:0005829,GO:0070125,GO:0070126" fibrillar center|RNA binding|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|cytosol|mitochondrial translational elongation|mitochondrial translational termination CHCHD10 512.1252042 591.7193296 432.5310789 0.730973381 -0.452109225 0.265867605 1 41.5651825 31.6918202 400916 coiled-coil-helix-coiled-coil-helix domain containing 10 "GO:0003674,GO:0005515,GO:0005634,GO:0005739,GO:0005758,GO:0006119,GO:0007005,GO:0030322,GO:0051457,GO:0061617,GO:0065003,GO:0090144,GO:0099558,GO:1901030,GO:1903109,GO:1903852" molecular_function|protein binding|nucleus|mitochondrion|mitochondrial intermembrane space|oxidative phosphorylation|mitochondrion organization|stabilization of membrane potential|maintenance of protein location in nucleus|MICOS complex|protein-containing complex assembly|mitochondrial nucleoid organization|maintenance of synapse structure|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of mitochondrial transcription|positive regulation of cristae formation hsa05014 Amyotrophic lateral sclerosis CHCHD2 8511.407113 9107.199904 7915.614323 0.86916005 -0.202306231 0.542487387 1 575.8396341 522.0561776 51142 coiled-coil-helix-coiled-coil-helix domain containing 2 "GO:0005515,GO:0005634,GO:0005739,GO:0005758,GO:0007005,GO:0008134,GO:0034599,GO:0043565,GO:0045944,GO:1900037,GO:1905448" protein binding|nucleus|mitochondrion|mitochondrial intermembrane space|mitochondrion organization|transcription factor binding|cellular response to oxidative stress|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|regulation of cellular response to hypoxia|positive regulation of mitochondrial ATP synthesis coupled electron transport CHCHD3 1472.506378 1483.865626 1461.14713 0.984689654 -0.022258995 0.948743147 1 33.91360974 34.83287513 54927 coiled-coil-helix-coiled-coil-helix domain containing 3 "GO:0001401,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0007007,GO:0008053,GO:0019902,GO:0042407,GO:0060090,GO:0061617,GO:0070062,GO:0140275" SAM complex|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|inner mitochondrial membrane organization|mitochondrial fusion|phosphatase binding|cristae formation|molecular adaptor activity|MICOS complex|extracellular exosome|MIB complex CHCHD4 417.9394184 450.64045 385.2383869 0.854868636 -0.22622535 0.599814996 1 14.23789708 12.69583188 131474 coiled-coil-helix-coiled-coil-helix domain containing 4 "GO:0005515,GO:0005739,GO:0005758,GO:0015035,GO:0018171,GO:0022417,GO:0033108,GO:0045041,GO:0051084" protein binding|mitochondrion|mitochondrial intermembrane space|protein disulfide oxidoreductase activity|peptidyl-cysteine oxidation|protein maturation by protein folding|mitochondrial respiratory chain complex assembly|protein import into mitochondrial intermembrane space|'de novo' posttranslational protein folding CHCHD5 318.7355143 336.9653815 300.505647 0.891799762 -0.16520828 0.726249245 1 26.58272248 24.72764397 84269 coiled-coil-helix-coiled-coil-helix domain containing 5 "GO:0005515,GO:0005739,GO:0005758,GO:0008150" protein binding|mitochondrion|mitochondrial intermembrane space|biological_process CHCHD6 199.1703861 212.1257974 186.2149747 0.877851619 -0.187950989 0.733918993 1 0.812172914 0.743679048 84303 coiled-coil-helix-coiled-coil-helix domain containing 6 "GO:0001401,GO:0005515,GO:0005739,GO:0005743,GO:0005829,GO:0006974,GO:0007007,GO:0042407,GO:0061617,GO:0140275" SAM complex|protein binding|mitochondrion|mitochondrial inner membrane|cytosol|cellular response to DNA damage stimulus|inner mitochondrial membrane organization|cristae formation|MICOS complex|MIB complex CHCHD7 669.2073307 688.1401466 650.2745149 0.944973954 -0.08165353 0.833795692 1 18.64733591 18.38029858 79145 coiled-coil-helix-coiled-coil-helix domain containing 7 "GO:0003674,GO:0005575,GO:0005758,GO:0008150" molecular_function|cellular_component|mitochondrial intermembrane space|biological_process CHD1 1475.055892 1523.448909 1426.662875 0.936469131 -0.094696656 0.777053191 1 8.15702641 7.967852104 1105 chromodomain helicase DNA binding protein 1 "GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0016569,GO:0032508,GO:0035064,GO:0043923" DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|covalent chromatin modification|DNA duplex unwinding|methylated histone binding|positive regulation by host of viral transcription chromosome_remodelling_factor CHD1L 1373.450931 1380.340117 1366.561746 0.990018133 -0.014473145 0.967944056 1 16.10072717 16.62664292 9557 chromodomain helicase DNA binding protein 1 like "GO:0000166,GO:0000717,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006281,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006338,GO:0006974,GO:0016887,GO:0033683,GO:0070911" "nucleotide binding|nucleotide-excision repair, DNA duplex unwinding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|DNA repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|chromatin remodeling|cellular response to DNA damage stimulus|ATPase activity|nucleotide-excision repair, DNA incision|global genome nucleotide-excision repair" CHD2 3896.176186 3027.613654 4764.738718 1.573760481 0.654215986 0.040625562 0.927001456 16.12725608 26.47372462 1106 chromodomain helicase DNA binding protein 2 "GO:0000978,GO:0003677,GO:0003678,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0006325,GO:0006357,GO:0007517,GO:0032508,GO:0042393" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA binding|DNA helicase activity|RNA binding|protein binding|ATP binding|nucleus|chromatin organization|regulation of transcription by RNA polymerase II|muscle organ development|DNA duplex unwinding|histone binding CHD3 4154.830122 4409.983683 3899.676561 0.884283671 -0.177418846 0.578277373 1 27.44533252 25.31488928 1107 chromodomain helicase DNA binding protein 3 "GO:0000122,GO:0000976,GO:0003677,GO:0003678,GO:0003723,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0006333,GO:0006355,GO:0006357,GO:0007051,GO:0007098,GO:0008270,GO:0016581,GO:0016605,GO:0016887,GO:0032508,GO:0034451,GO:0036121,GO:0043044,GO:0070615,GO:1901796" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|DNA binding|DNA helicase activity|RNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|chromatin assembly or disassembly|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spindle organization|centrosome cycle|zinc ion binding|NuRD complex|PML body|ATPase activity|DNA duplex unwinding|centriolar satellite|double-stranded DNA helicase activity|ATP-dependent chromatin remodeling|nucleosome-dependent ATPase activity|regulation of signal transduction by p53 class mediator" chromosome_remodelling_factor CHD4 7936.508786 7962.329572 7910.688 0.993514264 -0.009387415 0.977745952 1 62.24168906 64.50173636 1108 chromodomain helicase DNA binding protein 4 "GO:0000785,GO:0001103,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005813,GO:0006357,GO:0008134,GO:0008270,GO:0016020,GO:0016581,GO:0031492,GO:0032508,GO:0032991,GO:0042826,GO:0043044,GO:0090575,GO:1901796" chromatin|RNA polymerase II repressing transcription factor binding|DNA binding|DNA helicase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|centrosome|regulation of transcription by RNA polymerase II|transcription factor binding|zinc ion binding|membrane|NuRD complex|nucleosomal DNA binding|DNA duplex unwinding|protein-containing complex|histone deacetylase binding|ATP-dependent chromatin remodeling|RNA polymerase II transcription regulator complex|regulation of signal transduction by p53 class mediator "hsa05165,hsa05203" Human papillomavirus infection|Viral carcinogenesis chromosome_remodelling_factor CHD5 17.88321726 10.14955968 25.61687483 2.523939523 1.335677342 0.253406504 1 0.05218674 0.137389975 26038 chromodomain helicase DNA binding protein 5 "GO:0000792,GO:0003677,GO:0003678,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0008285,GO:0016020,GO:0016581,GO:0016607,GO:0021895,GO:0032508,GO:0035093,GO:0043967,GO:0046872,GO:0061628,GO:0098532,GO:1901798" "heterochromatin|DNA binding|DNA helicase activity|ATP binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|negative regulation of cell population proliferation|membrane|NuRD complex|nuclear speck|cerebral cortex neuron differentiation|DNA duplex unwinding|spermatogenesis, exchange of chromosomal proteins|histone H4 acetylation|metal ion binding|H3K27me3 modified histone binding|histone H3-K27 trimethylation|positive regulation of signal transduction by p53 class mediator" CHD6 2684.025565 3109.825087 2258.226043 0.726158539 -0.461643534 0.147698394 1 11.73808838 8.890880103 84181 chromodomain helicase DNA binding protein 6 "GO:0001221,GO:0003677,GO:0003678,GO:0005524,GO:0005654,GO:0006325,GO:0008094,GO:0016032,GO:0032508,GO:0036091" transcription coregulator binding|DNA binding|DNA helicase activity|ATP binding|nucleoplasm|chromatin organization|DNA-dependent ATPase activity|viral process|DNA duplex unwinding|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress CHD7 1388.278394 1518.374129 1258.18266 0.828638105 -0.271185931 0.418329695 1 6.442718927 5.568651186 55636 chromodomain helicase DNA binding protein 7 "GO:0000978,GO:0001501,GO:0001701,GO:0001974,GO:0003007,GO:0003222,GO:0003226,GO:0003678,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006338,GO:0006355,GO:0006364,GO:0007417,GO:0007512,GO:0007605,GO:0007628,GO:0008015,GO:0009617,GO:0010880,GO:0021545,GO:0021553,GO:0021772,GO:0030217,GO:0030540,GO:0032508,GO:0035116,GO:0035909,GO:0036302,GO:0040018,GO:0042048,GO:0042472,GO:0043584,GO:0045944,GO:0048752,GO:0048806,GO:0050767,GO:0050890,GO:0060041,GO:0060123,GO:0060173,GO:0060324,GO:0060384,GO:0060411,GO:0060429,GO:0062009,GO:1990841" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|skeletal system development|in utero embryonic development|blood vessel remodeling|heart morphogenesis|ventricular trabecula myocardium morphogenesis|right ventricular compact myocardium morphogenesis|DNA helicase activity|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|chromatin remodeling|regulation of transcription, DNA-templated|rRNA processing|central nervous system development|adult heart development|sensory perception of sound|adult walking behavior|blood circulation|response to bacterium|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|cranial nerve development|olfactory nerve development|olfactory bulb development|T cell differentiation|female genitalia development|DNA duplex unwinding|embryonic hindlimb morphogenesis|aorta morphogenesis|atrioventricular canal development|positive regulation of multicellular organism growth|olfactory behavior|inner ear morphogenesis|nose development|positive regulation of transcription by RNA polymerase II|semicircular canal morphogenesis|genitalia development|regulation of neurogenesis|cognition|retina development in camera-type eye|regulation of growth hormone secretion|limb development|face development|innervation|cardiac septum morphogenesis|epithelium development|secondary palate development|promoter-specific chromatin binding" other CHD8 3666.568753 3530.016858 3803.120648 1.077366143 0.107508634 0.73598626 1 20.91272672 23.50119335 57680 chromodomain helicase DNA binding protein 8 "GO:0000122,GO:0001701,GO:0002039,GO:0003677,GO:0003678,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0007420,GO:0008013,GO:0008094,GO:0016055,GO:0032508,GO:0032991,GO:0035064,GO:0035176,GO:0042393,GO:0043044,GO:0045892,GO:0045893,GO:0045944,GO:0045945,GO:0048565,GO:0060134,GO:0070016,GO:0071339,GO:0090090,GO:2000270" "negative regulation of transcription by RNA polymerase II|in utero embryonic development|p53 binding|DNA binding|DNA helicase activity|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|brain development|beta-catenin binding|DNA-dependent ATPase activity|Wnt signaling pathway|DNA duplex unwinding|protein-containing complex|methylated histone binding|social behavior|histone binding|ATP-dependent chromatin remodeling|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase III|digestive tract development|prepulse inhibition|armadillo repeat domain binding|MLL1 complex|negative regulation of canonical Wnt signaling pathway|negative regulation of fibroblast apoptotic process" hsa04310 Wnt signaling pathway CHD9 1113.731321 1171.259188 1056.203455 0.901767487 -0.149172599 0.667779716 1 4.578938317 4.307004206 80205 chromodomain helicase DNA binding protein 9 "GO:0003677,GO:0003678,GO:0005524,GO:0005654,GO:0005829,GO:0006325,GO:0019216,GO:0032508" DNA binding|DNA helicase activity|ATP binding|nucleoplasm|cytosol|chromatin organization|regulation of lipid metabolic process|DNA duplex unwinding CHEK1 1015.672025 933.7594909 1097.58456 1.175446751 0.233209185 0.507675274 1 9.344324068 11.456891 1111 checkpoint kinase 1 "GO:0000077,GO:0000781,GO:0000785,GO:0000794,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006260,GO:0006281,GO:0006468,GO:0006915,GO:0006974,GO:0006975,GO:0010569,GO:0010767,GO:0016301,GO:0018107,GO:0019904,GO:0032991,GO:0035402,GO:0035407,GO:0035556,GO:0043231,GO:0044818,GO:0045787,GO:0045839,GO:0046602,GO:0048096,GO:0070317,GO:0071260,GO:0072425,GO:0090399,GO:0106310,GO:0106311,GO:1901796,GO:2000615" "DNA damage checkpoint|chromosome, telomeric region|chromatin|condensed nuclear chromosome|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|extracellular space|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA replication|DNA repair|protein phosphorylation|apoptotic process|cellular response to DNA damage stimulus|DNA damage induced protein phosphorylation|regulation of double-strand break repair via homologous recombination|regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|kinase activity|peptidyl-threonine phosphorylation|protein domain specific binding|protein-containing complex|histone kinase activity (H3-T11 specific)|histone H3-T11 phosphorylation|intracellular signal transduction|intracellular membrane-bounded organelle|mitotic G2/M transition checkpoint|positive regulation of cell cycle|negative regulation of mitotic nuclear division|regulation of mitotic centrosome separation|chromatin-mediated maintenance of transcription|negative regulation of G0 to G1 transition|cellular response to mechanical stimulus|signal transduction involved in G2 DNA damage checkpoint|replicative senescence|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|regulation of histone H3-K9 acetylation" "hsa04110,hsa04115,hsa04218,hsa05166,hsa05170,hsa05203" Cell cycle|p53 signaling pathway|Cellular senescence|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis CHEK2 486.3289423 411.0571672 561.6007174 1.36623507 0.45020573 0.274225368 1 7.21865305 10.28720815 11200 checkpoint kinase 2 "GO:0000077,GO:0000086,GO:0000781,GO:0001934,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0006302,GO:0006355,GO:0006468,GO:0006974,GO:0006975,GO:0006977,GO:0006978,GO:0008630,GO:0016301,GO:0016605,GO:0018105,GO:0019901,GO:0031625,GO:0035690,GO:0042176,GO:0042770,GO:0042771,GO:0042802,GO:0042803,GO:0044257,GO:0044773,GO:0045893,GO:0046777,GO:0046872,GO:0050821,GO:0051301,GO:0071157,GO:0071480,GO:0072428,GO:0090307,GO:0090399,GO:0106310,GO:0106311,GO:1901796,GO:1903416,GO:1903926,GO:2000002,GO:2000210" "DNA damage checkpoint|G2/M transition of mitotic cell cycle|chromosome, telomeric region|positive regulation of protein phosphorylation|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|double-strand break repair|regulation of transcription, DNA-templated|protein phosphorylation|cellular response to DNA damage stimulus|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|intrinsic apoptotic signaling pathway in response to DNA damage|kinase activity|PML body|peptidyl-serine phosphorylation|protein kinase binding|ubiquitin protein ligase binding|cellular response to drug|regulation of protein catabolic process|signal transduction in response to DNA damage|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|protein homodimerization activity|cellular protein catabolic process|mitotic DNA damage checkpoint|positive regulation of transcription, DNA-templated|protein autophosphorylation|metal ion binding|protein stabilization|cell division|negative regulation of cell cycle arrest|cellular response to gamma radiation|signal transduction involved in intra-S DNA damage checkpoint|mitotic spindle assembly|replicative senescence|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|response to glycoside|cellular response to bisphenol A|negative regulation of DNA damage checkpoint|positive regulation of anoikis" "hsa04110,hsa04115,hsa04218,hsa05166" Cell cycle|p53 signaling pathway|Cellular senescence|Human T-cell leukemia virus 1 infection CHERP 1080.546814 1159.079716 1002.013912 0.864490939 -0.210077253 0.546650311 1 14.40571745 12.99006331 10523 calcium homeostasis endoplasmic reticulum protein "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0006874,GO:0007399,GO:0008285,GO:0016020,GO:0033017,GO:0044325,GO:0048471,GO:0051209,GO:0070886" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|cytoplasm|cellular calcium ion homeostasis|nervous system development|negative regulation of cell population proliferation|membrane|sarcoplasmic reticulum membrane|ion channel binding|perinuclear region of cytoplasm|release of sequestered calcium ion into cytosol|positive regulation of calcineurin-NFAT signaling cascade" hsa03040 Spliceosome CHFR 717.5931669 830.2339821 604.9523518 0.728652843 -0.456696469 0.224272832 1 3.698190176 2.810773396 55743 checkpoint with forkhead and ring finger domains "GO:0000166,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0006511,GO:0007093,GO:0016567,GO:0016605,GO:0019941,GO:0031398,GO:0031648,GO:0032436,GO:0044779,GO:0046872,GO:0051301,GO:0061630" nucleotide binding|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|ubiquitin-dependent protein catabolic process|mitotic cell cycle checkpoint|protein ubiquitination|PML body|modification-dependent protein catabolic process|positive regulation of protein ubiquitination|protein destabilization|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|meiotic spindle checkpoint|metal ion binding|cell division|ubiquitin protein ligase activity CHGB 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.104394678 0.063423636 1114 chromogranin B "GO:0005179,GO:0005515,GO:0005615,GO:0005788,GO:0007165,GO:0030141,GO:0043687,GO:0044267" hormone activity|protein binding|extracellular space|endoplasmic reticulum lumen|signal transduction|secretory granule|post-translational protein modification|cellular protein metabolic process CHIC1 244.887942 306.5167024 183.2591815 0.597876657 -0.742080209 0.14192625 1 1.641881507 1.023927811 53344 cysteine rich hydrophobic domain 1 "GO:0005886,GO:0031410" plasma membrane|cytoplasmic vesicle CHIC2 197.7667183 217.2005772 178.3328594 0.821051498 -0.284455381 0.603150295 1 0.74267101 0.636037613 26511 cysteine rich hydrophobic domain 2 "GO:0003674,GO:0005515,GO:0005794,GO:0005798,GO:0005886,GO:0008150,GO:0043231" molecular_function|protein binding|Golgi apparatus|Golgi-associated vesicle|plasma membrane|biological_process|intracellular membrane-bounded organelle CHID1 1537.552634 1619.869726 1455.235543 0.898365789 -0.154625107 0.640781569 1 18.92518732 17.73410687 66005 chitinase domain containing 1 "GO:0002576,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005764,GO:0005770,GO:0005802,GO:0005975,GO:0008061,GO:0016020,GO:0043202,GO:0045087,GO:0070062,GO:0070492,GO:1900016" platelet degranulation|protein binding|extracellular region|extracellular space|nucleus|lysosome|late endosome|trans-Golgi network|carbohydrate metabolic process|chitin binding|membrane|lysosomal lumen|innate immune response|extracellular exosome|oligosaccharide binding|negative regulation of cytokine production involved in inflammatory response CHKA 520.5674997 495.2985126 545.8364868 1.102035385 0.140170547 0.732109446 1 5.018028076 5.76825639 1119 choline kinase alpha "GO:0004103,GO:0004104,GO:0004305,GO:0005524,GO:0005829,GO:0006580,GO:0006629,GO:0006646,GO:0006656,GO:0006657,GO:0006869,GO:0008144,GO:0009636,GO:0016310,GO:0019695,GO:0033265,GO:0042802,GO:1904681" choline kinase activity|cholinesterase activity|ethanolamine kinase activity|ATP binding|cytosol|ethanolamine metabolic process|lipid metabolic process|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|CDP-choline pathway|lipid transport|drug binding|response to toxic substance|phosphorylation|choline metabolic process|choline binding|identical protein binding|response to 3-methylcholanthrene "hsa00564,hsa05231" Glycerophospholipid metabolism|Choline metabolism in cancer CHKB 393.8976797 356.2495449 431.5458144 1.21135822 0.276625558 0.527251105 1 12.24069381 15.46658935 1120 choline kinase beta "GO:0004103,GO:0004305,GO:0005524,GO:0005829,GO:0006646,GO:0006656,GO:0006657,GO:0016310" choline kinase activity|ethanolamine kinase activity|ATP binding|cytosol|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|CDP-choline pathway|phosphorylation "hsa00564,hsa05231" Glycerophospholipid metabolism|Choline metabolism in cancer CHM 1148.713651 1104.272094 1193.155208 1.08049023 0.111686027 0.747382962 1 5.961147506 6.718412146 1121 CHM Rab escort protein "GO:0004663,GO:0005092,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005968,GO:0006612,GO:0007264,GO:0007601,GO:0016192,GO:0018215,GO:0018344,GO:0031267,GO:0042981,GO:0043547,GO:0043687" Rab geranylgeranyltransferase activity|GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|Rab-protein geranylgeranyltransferase complex|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|vesicle-mediated transport|protein phosphopantetheinylation|protein geranylgeranylation|small GTPase binding|regulation of apoptotic process|positive regulation of GTPase activity|post-translational protein modification CHML 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.019937307 1122 CHM like Rab escort protein "GO:0005092,GO:0005096,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005968,GO:0006886,GO:0007264,GO:0016192,GO:0018344,GO:0031267,GO:0043547,GO:0043687" GDP-dissociation inhibitor activity|GTPase activator activity|nucleus|nucleoplasm|cytoplasm|cytosol|Rab-protein geranylgeranyltransferase complex|intracellular protein transport|small GTPase mediated signal transduction|vesicle-mediated transport|protein geranylgeranylation|small GTPase binding|positive regulation of GTPase activity|post-translational protein modification CHMP1A 1892.594474 1946.685547 1838.503401 0.944427519 -0.082488015 0.800002716 1 28.59418662 28.16840849 5119 charged multivesicular body protein 1A "GO:0000794,GO:0000815,GO:0005515,GO:0005769,GO:0005771,GO:0005815,GO:0006508,GO:0006997,GO:0007076,GO:0007080,GO:0008237,GO:0008270,GO:0010824,GO:0012505,GO:0015031,GO:0016192,GO:0016363,GO:0016458,GO:0019904,GO:0032509,GO:0036258,GO:0039702,GO:0042802,GO:0042803,GO:0045324,GO:0045786,GO:0045892,GO:0051301,GO:0061952,GO:0070062,GO:1901673,GO:1904903" "condensed nuclear chromosome|ESCRT III complex|protein binding|early endosome|multivesicular body|microtubule organizing center|proteolysis|nucleus organization|mitotic chromosome condensation|mitotic metaphase plate congression|metallopeptidase activity|zinc ion binding|regulation of centrosome duplication|endomembrane system|protein transport|vesicle-mediated transport|nuclear matrix|gene silencing|protein domain specific binding|endosome transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|late endosome to vacuole transport|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|cell division|midbody abscission|extracellular exosome|regulation of mitotic spindle assembly|ESCRT III complex disassembly" "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP1B 1617.978615 1527.508732 1708.448498 1.118454161 0.16150613 0.62382443 1 25.51547776 29.76718894 57132 charged multivesicular body protein 1B "GO:0000815,GO:0005515,GO:0005654,GO:0005771,GO:0005829,GO:0006997,GO:0007080,GO:0010008,GO:0010824,GO:0015031,GO:0019904,GO:0030117,GO:0030496,GO:0031902,GO:0032509,GO:0036258,GO:0039702,GO:0042802,GO:0045184,GO:0045324,GO:0051301,GO:0061952,GO:0070062,GO:1901673,GO:1904903" ESCRT III complex|protein binding|nucleoplasm|multivesicular body|cytosol|nucleus organization|mitotic metaphase plate congression|endosome membrane|regulation of centrosome duplication|protein transport|protein domain specific binding|membrane coat|midbody|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|establishment of protein localization|late endosome to vacuole transport|cell division|midbody abscission|extracellular exosome|regulation of mitotic spindle assembly|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP2A 1238.392756 1408.758884 1068.026628 0.75813302 -0.399477092 0.240709099 1 70.15601541 55.4786976 27243 charged multivesicular body protein 2A "GO:0000785,GO:0000815,GO:0005515,GO:0005635,GO:0005771,GO:0005829,GO:0006997,GO:0007080,GO:0010324,GO:0010458,GO:0010824,GO:0015031,GO:0016020,GO:0016197,GO:0016236,GO:0019058,GO:0019904,GO:0030117,GO:0031210,GO:0031468,GO:0031902,GO:0032509,GO:0036258,GO:0039702,GO:0045184,GO:0045324,GO:0050792,GO:0051258,GO:0051260,GO:0060548,GO:0061952,GO:0070062,GO:1901673,GO:1902188,GO:1903543,GO:1903723,GO:1904903" chromatin|ESCRT III complex|protein binding|nuclear envelope|multivesicular body|cytosol|nucleus organization|mitotic metaphase plate congression|membrane invagination|exit from mitosis|regulation of centrosome duplication|protein transport|membrane|endosomal transport|macroautophagy|viral life cycle|protein domain specific binding|membrane coat|phosphatidylcholine binding|nuclear envelope reassembly|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|establishment of protein localization|late endosome to vacuole transport|regulation of viral process|protein polymerization|protein homooligomerization|negative regulation of cell death|midbody abscission|extracellular exosome|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|positive regulation of exosomal secretion|negative regulation of centriole elongation|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP2B 999.3585011 896.2061201 1102.510882 1.230197895 0.298890412 0.396738984 1 17.07662843 21.91255594 25978 charged multivesicular body protein 2B "GO:0000815,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005770,GO:0005771,GO:0005829,GO:0005886,GO:0006914,GO:0006997,GO:0007032,GO:0007080,GO:0010824,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0019904,GO:0031902,GO:0032509,GO:0036258,GO:0039702,GO:0045296,GO:0045324,GO:0050890,GO:0061763,GO:0061952,GO:0070050,GO:0070062,GO:1901673,GO:1902188,GO:1904903" ESCRT III complex|protein binding|cytoplasm|lysosome|endosome|late endosome|multivesicular body|cytosol|plasma membrane|autophagy|nucleus organization|endosome organization|mitotic metaphase plate congression|regulation of centrosome duplication|protein transport|endosomal transport|macroautophagy|viral life cycle|protein domain specific binding|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|cadherin binding|late endosome to vacuole transport|cognition|multivesicular body-lysosome fusion|midbody abscission|neuron cellular homeostasis|extracellular exosome|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|ESCRT III complex disassembly "hsa04144,hsa04217,hsa05014,hsa05022" Endocytosis|Necroptosis|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases CHMP3 4.493072978 4.059823873 4.926322083 1.213432463 0.279093814 1 1 0.06552446 0.082934455 51652 charged multivesicular body protein 3 "GO:0000815,GO:0005515,GO:0005770,GO:0005771,GO:0005829,GO:0005886,GO:0006915,GO:0006997,GO:0007080,GO:0010824,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0031210,GO:0031410,GO:0031902,GO:0032509,GO:0036258,GO:0039702,GO:0045324,GO:0050792,GO:0051258,GO:0061763,GO:0061952,GO:0070062,GO:0071985,GO:0097352,GO:1901673,GO:1902187,GO:1902188,GO:1903541,GO:1990381,GO:2000641" ESCRT III complex|protein binding|late endosome|multivesicular body|cytosol|plasma membrane|apoptotic process|nucleus organization|mitotic metaphase plate congression|regulation of centrosome duplication|protein transport|endosomal transport|macroautophagy|viral life cycle|phosphatidylcholine binding|cytoplasmic vesicle|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|late endosome to vacuole transport|regulation of viral process|protein polymerization|multivesicular body-lysosome fusion|midbody abscission|extracellular exosome|multivesicular body sorting pathway|autophagosome maturation|regulation of mitotic spindle assembly|negative regulation of viral release from host cell|positive regulation of viral release from host cell|regulation of exosomal secretion|ubiquitin-specific protease binding|regulation of early endosome to late endosome transport "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP4A 582.3583259 644.4970399 520.2196119 0.807171453 -0.309052944 0.433219629 1 33.30765451 28.04308412 29082 charged multivesicular body protein 4A "GO:0000815,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005771,GO:0005829,GO:0005886,GO:0006620,GO:0006900,GO:0006997,GO:0007080,GO:0008289,GO:0009898,GO:0010324,GO:0016197,GO:0016236,GO:0019058,GO:0030117,GO:0030496,GO:0030659,GO:0031902,GO:0032511,GO:0036258,GO:0039702,GO:0042802,GO:0042803,GO:0051117,GO:0051258,GO:0061952,GO:0097320,GO:1901215,GO:1902902" ESCRT III complex|protein binding|nucleus|cytoplasm|endosome|multivesicular body|cytosol|plasma membrane|posttranslational protein targeting to endoplasmic reticulum membrane|vesicle budding from membrane|nucleus organization|mitotic metaphase plate congression|lipid binding|cytoplasmic side of plasma membrane|membrane invagination|endosomal transport|macroautophagy|viral life cycle|membrane coat|midbody|cytoplasmic vesicle membrane|late endosome membrane|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|ATPase binding|protein polymerization|midbody abscission|plasma membrane tubulation|negative regulation of neuron death|negative regulation of autophagosome assembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP4B 3868.979724 3727.933272 4010.026175 1.075670052 0.105235617 0.741549624 1 117.856847 132.236037 128866 charged multivesicular body protein 4B "GO:0000281,GO:0000815,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005768,GO:0005771,GO:0005829,GO:0006620,GO:0006900,GO:0006914,GO:0006997,GO:0007080,GO:0009898,GO:0010458,GO:0010824,GO:0016197,GO:0016236,GO:0019058,GO:0030117,GO:0030496,GO:0031468,GO:0031902,GO:0031982,GO:0032511,GO:0036258,GO:0036438,GO:0039702,GO:0042802,GO:0042803,GO:0045296,GO:0046755,GO:0050792,GO:0051258,GO:0060548,GO:0061952,GO:0070062,GO:0090148,GO:0090611,GO:1901215,GO:1901673,GO:1902188,GO:1902902" mitotic cytokinesis|ESCRT III complex|protein binding|nucleus|nuclear envelope|cytoplasm|endosome|multivesicular body|cytosol|posttranslational protein targeting to endoplasmic reticulum membrane|vesicle budding from membrane|autophagy|nucleus organization|mitotic metaphase plate congression|cytoplasmic side of plasma membrane|exit from mitosis|regulation of centrosome duplication|endosomal transport|macroautophagy|viral life cycle|membrane coat|midbody|nuclear envelope reassembly|late endosome membrane|vesicle|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|maintenance of lens transparency|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|cadherin binding|viral budding|regulation of viral process|protein polymerization|negative regulation of cell death|midbody abscission|extracellular exosome|membrane fission|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|negative regulation of neuron death|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|negative regulation of autophagosome assembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP4C 539.1296633 417.146903 661.1124235 1.584843178 0.664340091 0.098089165 1 11.40767766 18.85816649 92421 charged multivesicular body protein 4C "GO:0000815,GO:0005515,GO:0005771,GO:0005829,GO:0006900,GO:0006997,GO:0007080,GO:0009838,GO:0009898,GO:0010824,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0030496,GO:0031902,GO:0032466,GO:0032511,GO:0036258,GO:0039702,GO:0042803,GO:0044878,GO:0050792,GO:0061952,GO:0090543,GO:0090611,GO:1901673,GO:1902188" ESCRT III complex|protein binding|multivesicular body|cytosol|vesicle budding from membrane|nucleus organization|mitotic metaphase plate congression|abscission|cytoplasmic side of plasma membrane|regulation of centrosome duplication|protein transport|endosomal transport|macroautophagy|viral life cycle|midbody|late endosome membrane|negative regulation of cytokinesis|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|protein homodimerization activity|mitotic cytokinesis checkpoint|regulation of viral process|midbody abscission|Flemming body|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|regulation of mitotic spindle assembly|positive regulation of viral release from host cell "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP5 2093.979849 1906.087309 2281.872389 1.197149983 0.259603909 0.419277469 1 50.78200837 63.41242564 51510 charged multivesicular body protein 5 "GO:0001919,GO:0005515,GO:0005634,GO:0005771,GO:0005829,GO:0006900,GO:0006997,GO:0007040,GO:0007080,GO:0008333,GO:0010008,GO:0010824,GO:0015031,GO:0016197,GO:0019058,GO:0032511,GO:0036258,GO:0045296,GO:0046755,GO:0061952,GO:0070062,GO:0071222,GO:0071225,GO:0071985,GO:1901673,GO:1904903" regulation of receptor recycling|protein binding|nucleus|multivesicular body|cytosol|vesicle budding from membrane|nucleus organization|lysosome organization|mitotic metaphase plate congression|endosome to lysosome transport|endosome membrane|regulation of centrosome duplication|protein transport|endosomal transport|viral life cycle|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|cadherin binding|viral budding|midbody abscission|extracellular exosome|cellular response to lipopolysaccharide|cellular response to muramyl dipeptide|multivesicular body sorting pathway|regulation of mitotic spindle assembly|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP6 323.0652837 329.8606897 316.2698777 0.958798328 -0.060700702 0.90205021 1 8.755912084 8.756783045 79643 charged multivesicular body protein 6 "GO:0000815,GO:0005515,GO:0005771,GO:0005829,GO:0006900,GO:0006997,GO:0007080,GO:0007175,GO:0010008,GO:0015031,GO:0016020,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0032511,GO:0036258,GO:0039702,GO:0042176,GO:0044877,GO:0047485,GO:0061952,GO:0070062,GO:1903541,GO:1904902" ESCRT III complex|protein binding|multivesicular body|cytosol|vesicle budding from membrane|nucleus organization|mitotic metaphase plate congression|negative regulation of epidermal growth factor-activated receptor activity|endosome membrane|protein transport|membrane|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|regulation of protein catabolic process|protein-containing complex binding|protein N-terminus binding|midbody abscission|extracellular exosome|regulation of exosomal secretion|ESCRT III complex assembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP7 833.0945119 811.9647747 854.2242491 1.052045946 0.073197712 0.843649809 1 11.35684932 12.46259554 91782 charged multivesicular body protein 7 "GO:0000785,GO:0000815,GO:0005515,GO:0005635,GO:0005654,GO:0005771,GO:0005829,GO:0006900,GO:0006997,GO:0007080,GO:0010458,GO:0015031,GO:0016197,GO:0019058,GO:0031468,GO:0032511,GO:0036258,GO:0039702,GO:0045324,GO:0061952,GO:0071168,GO:1904903" chromatin|ESCRT III complex|protein binding|nuclear envelope|nucleoplasm|multivesicular body|cytosol|vesicle budding from membrane|nucleus organization|mitotic metaphase plate congression|exit from mitosis|protein transport|endosomal transport|viral life cycle|nuclear envelope reassembly|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|late endosome to vacuole transport|midbody abscission|protein localization to chromatin|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHN1 179.3490531 170.5126027 188.1855036 1.103645716 0.142277124 0.807007726 1 2.311526176 2.660997261 1123 chimerin 1 "GO:0005096,GO:0005515,GO:0005829,GO:0008045,GO:0035556,GO:0043087,GO:0043547,GO:0046872,GO:0046875,GO:0048013,GO:0050770,GO:0051056" GTPase activator activity|protein binding|cytosol|motor neuron axon guidance|intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|metal ion binding|ephrin receptor binding|ephrin receptor signaling pathway|regulation of axonogenesis|regulation of small GTPase mediated signal transduction CHN2 39.01914328 40.59823873 37.44004783 0.922208672 -0.116834863 0.926907627 1 0.414464336 0.398687204 1124 chimerin 2 "GO:0005096,GO:0005515,GO:0005829,GO:0016020,GO:0035556,GO:0043087,GO:0043547,GO:0045202,GO:0046872,GO:0051056" GTPase activator activity|protein binding|cytosol|membrane|intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|synapse|metal ion binding|regulation of small GTPase mediated signal transduction CHORDC1 951.7971013 1079.91315 823.6810522 0.762728977 -0.390757585 0.271766007 1 16.32163275 12.98523392 26973 cysteine and histidine rich domain containing 1 "GO:0005515,GO:0005524,GO:0005575,GO:0008270,GO:0010824,GO:0043531,GO:0051298,GO:0051879,GO:0061077,GO:1900034,GO:2000299" protein binding|ATP binding|cellular_component|zinc ion binding|regulation of centrosome duplication|ADP binding|centrosome duplication|Hsp90 protein binding|chaperone-mediated protein folding|regulation of cellular response to heat|negative regulation of Rho-dependent protein serine/threonine kinase activity CHP1 1982.816438 1816.771183 2148.861692 1.182791599 0.242195901 0.452832017 1 27.13448872 33.47694384 11261 calcineurin like EF-hand protein 1 "GO:0000139,GO:0001578,GO:0001933,GO:0004860,GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005793,GO:0005829,GO:0005886,GO:0005925,GO:0006469,GO:0006611,GO:0006813,GO:0006903,GO:0006906,GO:0007264,GO:0008017,GO:0010923,GO:0015459,GO:0015630,GO:0019900,GO:0022406,GO:0030133,GO:0030214,GO:0031122,GO:0031397,GO:0031953,GO:0032088,GO:0032417,GO:0042308,GO:0048306,GO:0050821,GO:0051222,GO:0051259,GO:0051453,GO:0060050,GO:0061024,GO:0061025,GO:0070062,GO:0070885,GO:0071073,GO:0071468,GO:0090314,GO:1901214" Golgi membrane|microtubule bundle formation|negative regulation of protein phosphorylation|protein kinase inhibitor activity|calcium ion binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|focal adhesion|negative regulation of protein kinase activity|protein export from nucleus|potassium ion transport|vesicle targeting|vesicle fusion|small GTPase mediated signal transduction|microtubule binding|negative regulation of phosphatase activity|potassium channel regulator activity|microtubule cytoskeleton|kinase binding|membrane docking|transport vesicle|hyaluronan catabolic process|cytoplasmic microtubule organization|negative regulation of protein ubiquitination|negative regulation of protein autophosphorylation|negative regulation of NF-kappaB transcription factor activity|positive regulation of sodium:proton antiporter activity|negative regulation of protein import into nucleus|calcium-dependent protein binding|protein stabilization|positive regulation of protein transport|protein complex oligomerization|regulation of intracellular pH|positive regulation of protein glycosylation|membrane organization|membrane fusion|extracellular exosome|negative regulation of calcineurin-NFAT signaling cascade|positive regulation of phospholipid biosynthetic process|cellular response to acidic pH|positive regulation of protein targeting to membrane|regulation of neuron death CHPF 1729.140542 1818.801095 1639.479989 0.901406973 -0.149749485 0.647042968 1 27.92235803 26.25360425 79586 chondroitin polymerizing factor "GO:0000139,GO:0005759,GO:0005829,GO:0008376,GO:0016021,GO:0030206,GO:0032580,GO:0046872,GO:0047238,GO:0050510" Golgi membrane|mitochondrial matrix|cytosol|acetylgalactosaminyltransferase activity|integral component of membrane|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHPF2 1609.478175 1788.352416 1430.603933 0.799956384 -0.322006752 0.327499231 1 33.32367217 27.80578061 54480 chondroitin polymerizing factor 2 "GO:0000139,GO:0008376,GO:0016020,GO:0016021,GO:0030206,GO:0032580,GO:0047238,GO:0050510" Golgi membrane|acetylgalactosaminyltransferase activity|membrane|integral component of membrane|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHPT1 875.339394 837.3386739 913.3401141 1.090765472 0.125340938 0.73046234 1 24.02733704 27.33713216 56994 choline phosphotransferase 1 "GO:0000139,GO:0001558,GO:0004142,GO:0005515,GO:0005789,GO:0005794,GO:0006629,GO:0006656,GO:0006657,GO:0006663,GO:0016020,GO:0016021,GO:0019992,GO:0043231,GO:0046872" Golgi membrane|regulation of cell growth|diacylglycerol cholinephosphotransferase activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|lipid metabolic process|phosphatidylcholine biosynthetic process|CDP-choline pathway|platelet activating factor biosynthetic process|membrane|integral component of membrane|diacylglycerol binding|intracellular membrane-bounded organelle|metal ion binding "hsa00440,hsa00564,hsa00565,hsa05231" Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Choline metabolism in cancer CHRAC1 1906.902581 1678.737172 2135.067991 1.271829817 0.346905638 0.283572395 1 34.26929283 45.46216092 54108 chromatin accessibility complex subunit 1 "GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0006338,GO:0008622,GO:0008623,GO:0046982,GO:0071897" DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|chromatin remodeling|epsilon DNA polymerase complex|CHRAC|protein heterodimerization activity|DNA biosynthetic process CHRD 23.3912462 16.23929549 30.54319691 1.880820318 0.911362029 0.399144078 1 0.188941656 0.370673001 8646 chordin "GO:0001501,GO:0002053,GO:0005515,GO:0005615,GO:0019955,GO:0021919,GO:0030336,GO:0030514,GO:0033504,GO:0045668,GO:0045785" skeletal system development|positive regulation of mesenchymal cell proliferation|protein binding|extracellular space|cytokine binding|BMP signaling pathway involved in spinal cord dorsal/ventral patterning|negative regulation of cell migration|negative regulation of BMP signaling pathway|floor plate development|negative regulation of osteoblast differentiation|positive regulation of cell adhesion hsa04350 TGF-beta signaling pathway CHRDL1 175.1556173 153.2583512 197.0528833 1.285756252 0.362617169 0.522741012 1 1.981111492 2.656950674 91851 chordin like 1 "GO:0001503,GO:0001654,GO:0005576,GO:0005788,GO:0007399,GO:0030154,GO:0030509,GO:0030514,GO:0043687,GO:0044267" ossification|eye development|extracellular region|endoplasmic reticulum lumen|nervous system development|cell differentiation|BMP signaling pathway|negative regulation of BMP signaling pathway|post-translational protein modification|cellular protein metabolic process CHRFAM7A 16.91279862 11.16451565 22.66108158 2.029741575 1.021296056 0.394570588 1 0.150303916 0.318219635 89832 CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion "GO:0005230,GO:0005515,GO:0005887,GO:0005892,GO:0007165,GO:0007268,GO:0007271,GO:0015464,GO:0030594,GO:0034220,GO:0042166,GO:0042391,GO:0043005,GO:0045202,GO:0050877" "extracellular ligand-gated ion channel activity|protein binding|integral component of plasma membrane|acetylcholine-gated channel complex|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|acetylcholine receptor activity|neurotransmitter receptor activity|ion transmembrane transport|acetylcholine binding|regulation of membrane potential|neuron projection|synapse|nervous system process" CHRM4 17.53904281 20.29911937 14.77896625 0.728059478 -0.457871781 0.725187077 1 0.337739417 0.256486516 1132 cholinergic receptor muscarinic 4 "GO:0004993,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0007166,GO:0007186,GO:0007187,GO:0007197,GO:0007213,GO:0007268,GO:0016907,GO:0030425,GO:0030594,GO:0040012,GO:0045202,GO:0045211,GO:0098664" "G protein-coupled serotonin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|chemical synaptic transmission|G protein-coupled acetylcholine receptor activity|dendrite|neurotransmitter receptor activity|regulation of locomotion|synapse|postsynaptic membrane|G protein-coupled serotonin receptor signaling pathway" "hsa04080,hsa04725,hsa04810" Neuroactive ligand-receptor interaction|Cholinergic synapse|Regulation of actin cytoskeleton CHRNA10 20.0318954 22.3290313 17.7347595 0.794246703 -0.332340898 0.800682888 1 0.563471183 0.466813127 57053 cholinergic receptor nicotinic alpha 10 subunit "GO:0004888,GO:0005102,GO:0005262,GO:0005887,GO:0007165,GO:0007204,GO:0007268,GO:0007271,GO:0016020,GO:0022848,GO:0030424,GO:0030594,GO:0034220,GO:0042127,GO:0042391,GO:0042472,GO:0043005,GO:0043204,GO:0045202,GO:0050877,GO:0050910,GO:0060079,GO:0070373,GO:0070588,GO:0098981,GO:0099060" "transmembrane signaling receptor activity|signaling receptor binding|calcium channel activity|integral component of plasma membrane|signal transduction|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|synaptic transmission, cholinergic|membrane|acetylcholine-gated cation-selective channel activity|axon|neurotransmitter receptor activity|ion transmembrane transport|regulation of cell population proliferation|regulation of membrane potential|inner ear morphogenesis|neuron projection|perikaryon|synapse|nervous system process|detection of mechanical stimulus involved in sensory perception of sound|excitatory postsynaptic potential|negative regulation of ERK1 and ERK2 cascade|calcium ion transmembrane transport|cholinergic synapse|integral component of postsynaptic specialization membrane" hsa04080 Neuroactive ligand-receptor interaction CHRNA5 223.6656629 236.4847406 210.8465851 0.891586428 -0.16555344 0.756224193 1 4.223243246 3.927583933 1138 cholinergic receptor nicotinic alpha 5 subunit "GO:0005515,GO:0005886,GO:0005887,GO:0005892,GO:0007165,GO:0007268,GO:0007271,GO:0015276,GO:0015464,GO:0022848,GO:0030594,GO:0034220,GO:0035094,GO:0035095,GO:0042391,GO:0043005,GO:0045202,GO:0045211,GO:0050877,GO:0060079,GO:0098691,GO:2000300" "protein binding|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|ligand-gated ion channel activity|acetylcholine receptor activity|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|ion transmembrane transport|response to nicotine|behavioral response to nicotine|regulation of membrane potential|neuron projection|synapse|postsynaptic membrane|nervous system process|excitatory postsynaptic potential|dopaminergic synapse|regulation of synaptic vesicle exocytosis" hsa04080 Neuroactive ligand-receptor interaction CHRNA7 27.48076163 26.38885518 28.57266808 1.082755121 0.114706996 0.94795115 1 0.19513833 0.220388414 1139 cholinergic receptor nicotinic alpha 7 subunit "GO:0000187,GO:0001540,GO:0001666,GO:0001934,GO:0005216,GO:0005262,GO:0005515,GO:0005886,GO:0005887,GO:0005892,GO:0006811,GO:0006816,GO:0006874,GO:0007165,GO:0007268,GO:0007271,GO:0007611,GO:0007613,GO:0007614,GO:0008284,GO:0015464,GO:0015643,GO:0016021,GO:0017081,GO:0022848,GO:0030594,GO:0032720,GO:0034220,GO:0035094,GO:0042166,GO:0042391,GO:0042803,GO:0043005,GO:0044853,GO:0045202,GO:0045211,GO:0045766,GO:0050808,GO:0050877,GO:0050890,GO:0050893,GO:0051247,GO:0060079,GO:0070374,GO:0070588,GO:0095500,GO:0097061,GO:0098794,GO:0098815,GO:0140059,GO:1900273,GO:1901214,GO:1902004,GO:1902430,GO:1902991,GO:1904645,GO:1905144,GO:1905906,GO:1905920,GO:2000463" "activation of MAPK activity|amyloid-beta binding|response to hypoxia|positive regulation of protein phosphorylation|ion channel activity|calcium channel activity|protein binding|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|ion transport|calcium ion transport|cellular calcium ion homeostasis|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|learning or memory|memory|short-term memory|positive regulation of cell population proliferation|acetylcholine receptor activity|toxic substance binding|integral component of membrane|chloride channel regulator activity|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|negative regulation of tumor necrosis factor production|ion transmembrane transport|response to nicotine|acetylcholine binding|regulation of membrane potential|protein homodimerization activity|neuron projection|plasma membrane raft|synapse|postsynaptic membrane|positive regulation of angiogenesis|synapse organization|nervous system process|cognition|sensory processing|positive regulation of protein metabolic process|excitatory postsynaptic potential|positive regulation of ERK1 and ERK2 cascade|calcium ion transmembrane transport|acetylcholine receptor signaling pathway|dendritic spine organization|postsynapse|modulation of excitatory postsynaptic potential|dendrite arborization|positive regulation of long-term synaptic potentiation|regulation of neuron death|positive regulation of amyloid-beta formation|negative regulation of amyloid-beta formation|regulation of amyloid precursor protein catabolic process|response to amyloid-beta|response to acetylcholine|regulation of amyloid fibril formation|positive regulation of CoA-transferase activity|positive regulation of excitatory postsynaptic potential" "hsa04020,hsa04080,hsa04725,hsa05010,hsa05022,hsa05033,hsa05204" Calcium signaling pathway|Neuroactive ligand-receptor interaction|Cholinergic synapse|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Nicotine addiction|Chemical carcinogenesis CHRNB1 1142.988379 1015.970924 1270.005833 1.250041514 0.321976008 0.350438642 1 20.09974343 26.20781895 1140 cholinergic receptor nicotinic beta 1 subunit "GO:0001941,GO:0003009,GO:0005515,GO:0005887,GO:0005892,GO:0006812,GO:0006936,GO:0007165,GO:0007268,GO:0007271,GO:0007274,GO:0015267,GO:0015276,GO:0015464,GO:0022848,GO:0030594,GO:0031594,GO:0034220,GO:0035095,GO:0042166,GO:0042391,GO:0043005,GO:0045202,GO:0048747,GO:0050877,GO:0060079,GO:0099060,GO:1904315" "postsynaptic membrane organization|skeletal muscle contraction|protein binding|integral component of plasma membrane|acetylcholine-gated channel complex|cation transport|muscle contraction|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|neuromuscular synaptic transmission|channel activity|ligand-gated ion channel activity|acetylcholine receptor activity|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|neuromuscular junction|ion transmembrane transport|behavioral response to nicotine|acetylcholine binding|regulation of membrane potential|neuron projection|synapse|muscle fiber development|nervous system process|excitatory postsynaptic potential|integral component of postsynaptic specialization membrane|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" hsa04080 Neuroactive ligand-receptor interaction CHRNB2 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.014633879 0.029635413 1141 cholinergic receptor nicotinic beta 2 subunit "GO:0001666,GO:0005515,GO:0005886,GO:0005887,GO:0005892,GO:0006811,GO:0006816,GO:0006939,GO:0007165,GO:0007268,GO:0007271,GO:0007601,GO:0007605,GO:0007612,GO:0007613,GO:0007626,GO:0008306,GO:0008542,GO:0009897,GO:0014059,GO:0015276,GO:0015464,GO:0016021,GO:0019233,GO:0021562,GO:0021631,GO:0021771,GO:0021952,GO:0022848,GO:0030594,GO:0030890,GO:0032225,GO:0033603,GO:0034220,GO:0035094,GO:0035095,GO:0035176,GO:0042053,GO:0042113,GO:0042166,GO:0042220,GO:0042320,GO:0042391,GO:0043005,GO:0044853,GO:0045202,GO:0045211,GO:0045471,GO:0045759,GO:0048814,GO:0050877,GO:0050890,GO:0051899,GO:0051963,GO:0060079,GO:0060084,GO:0095500,GO:1905144" "response to hypoxia|protein binding|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|ion transport|calcium ion transport|smooth muscle contraction|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|visual perception|sensory perception of sound|learning|memory|locomotory behavior|associative learning|visual learning|external side of plasma membrane|regulation of dopamine secretion|ligand-gated ion channel activity|acetylcholine receptor activity|integral component of membrane|sensory perception of pain|vestibulocochlear nerve development|optic nerve morphogenesis|lateral geniculate nucleus development|central nervous system projection neuron axonogenesis|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|positive regulation of B cell proliferation|regulation of synaptic transmission, dopaminergic|positive regulation of dopamine secretion|ion transmembrane transport|response to nicotine|behavioral response to nicotine|social behavior|regulation of dopamine metabolic process|B cell activation|acetylcholine binding|response to cocaine|regulation of circadian sleep/wake cycle, REM sleep|regulation of membrane potential|neuron projection|plasma membrane raft|synapse|postsynaptic membrane|response to ethanol|negative regulation of action potential|regulation of dendrite morphogenesis|nervous system process|cognition|membrane depolarization|regulation of synapse assembly|excitatory postsynaptic potential|synaptic transmission involved in micturition|acetylcholine receptor signaling pathway|response to acetylcholine" "hsa04080,hsa04725,hsa05033" Neuroactive ligand-receptor interaction|Cholinergic synapse|Nicotine addiction CHRNB4 14.01638847 15.22433953 12.80843742 0.841313174 -0.249285159 0.896625813 1 0.097220916 0.085316559 1143 cholinergic receptor nicotinic beta 4 subunit "GO:0005515,GO:0005886,GO:0005887,GO:0005892,GO:0006811,GO:0007165,GO:0007268,GO:0007271,GO:0015276,GO:0015464,GO:0016021,GO:0022848,GO:0030594,GO:0034220,GO:0035579,GO:0042166,GO:0042391,GO:0043005,GO:0043312,GO:0044877,GO:0045202,GO:0045211,GO:0046928,GO:0050877,GO:0060079,GO:0060084,GO:0070821" "protein binding|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|ion transport|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|ligand-gated ion channel activity|acetylcholine receptor activity|integral component of membrane|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|ion transmembrane transport|specific granule membrane|acetylcholine binding|regulation of membrane potential|neuron projection|neutrophil degranulation|protein-containing complex binding|synapse|postsynaptic membrane|regulation of neurotransmitter secretion|nervous system process|excitatory postsynaptic potential|synaptic transmission involved in micturition|tertiary granule membrane" "hsa04080,hsa04725" Neuroactive ligand-receptor interaction|Cholinergic synapse CHST10 416.580288 458.7600977 374.4004783 0.816113869 -0.293157635 0.49562432 1 6.349981017 5.405540369 9486 carbohydrate sulfotransferase 10 "GO:0000139,GO:0005794,GO:0007155,GO:0008146,GO:0016020,GO:0016021,GO:0016051,GO:0016232,GO:0030166" Golgi membrane|Golgi apparatus|cell adhesion|sulfotransferase activity|membrane|integral component of membrane|carbohydrate biosynthetic process|HNK-1 sulfotransferase activity|proteoglycan biosynthetic process hsa00515 Mannose type O-glycan biosynthesis CHST11 1407.02242 1957.850063 856.194778 0.437313763 -1.193259342 0.000419178 0.048560168 16.78940041 7.658509611 50515 carbohydrate sulfotransferase 11 "GO:0000139,GO:0001537,GO:0001701,GO:0002063,GO:0007585,GO:0008146,GO:0009791,GO:0016020,GO:0016021,GO:0016051,GO:0030166,GO:0030206,GO:0030512,GO:0033037,GO:0036342,GO:0042127,GO:0042733,GO:0043066,GO:0047756,GO:0048589,GO:0048703,GO:0050659" Golgi membrane|N-acetylgalactosamine 4-O-sulfotransferase activity|in utero embryonic development|chondrocyte development|respiratory gaseous exchange by respiratory system|sulfotransferase activity|post-embryonic development|membrane|integral component of membrane|carbohydrate biosynthetic process|proteoglycan biosynthetic process|chondroitin sulfate biosynthetic process|negative regulation of transforming growth factor beta receptor signaling pathway|polysaccharide localization|post-anal tail morphogenesis|regulation of cell population proliferation|embryonic digit morphogenesis|negative regulation of apoptotic process|chondroitin 4-sulfotransferase activity|developmental growth|embryonic viscerocranium morphogenesis|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST12 594.7983405 585.6295938 603.9670873 1.031312444 0.044481474 0.913884789 1 16.38678063 17.62786953 55501 carbohydrate sulfotransferase 12 "GO:0000139,GO:0008146,GO:0016020,GO:0016051,GO:0030166,GO:0030173,GO:0030206,GO:0030208,GO:0047756,GO:0050656" Golgi membrane|sulfotransferase activity|membrane|carbohydrate biosynthetic process|proteoglycan biosynthetic process|integral component of Golgi membrane|chondroitin sulfate biosynthetic process|dermatan sulfate biosynthetic process|chondroitin 4-sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate binding hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST14 981.3010939 1008.866233 953.7359552 0.945354225 -0.081073086 0.820955469 1 23.49219109 23.16509171 113189 carbohydrate sulfotransferase 14 "GO:0000139,GO:0001537,GO:0008146,GO:0016021,GO:0016051,GO:0030208,GO:0042301,GO:0050655,GO:0070062" Golgi membrane|N-acetylgalactosamine 4-O-sulfotransferase activity|sulfotransferase activity|integral component of membrane|carbohydrate biosynthetic process|dermatan sulfate biosynthetic process|phosphate ion binding|dermatan sulfate proteoglycan metabolic process|extracellular exosome hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST15 761.1660041 1047.434559 474.8974488 0.453391044 -1.1411722 0.002324424 0.153684114 5.130947413 2.426534279 51363 carbohydrate sulfotransferase 15 "GO:0000139,GO:0005515,GO:0016021,GO:0019319,GO:0030206,GO:0050656,GO:0050659" Golgi membrane|protein binding|integral component of membrane|hexose biosynthetic process|chondroitin sulfate biosynthetic process|3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST2 288.1599042 368.4290165 207.8907919 0.564262809 -0.825560831 0.085436739 1 4.504980673 2.651491802 9435 carbohydrate sulfotransferase 2 "GO:0000139,GO:0001517,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0005975,GO:0006044,GO:0006790,GO:0006954,GO:0007275,GO:0008146,GO:0016021,GO:0018146,GO:0031228" Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|carbohydrate metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|inflammatory response|multicellular organism development|sulfotransferase activity|integral component of membrane|keratan sulfate biosynthetic process|intrinsic component of Golgi membrane hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate CHST3 1310.016183 1253.470621 1366.561746 1.090222398 0.124622465 0.713359804 1 6.501829678 7.393781602 9469 carbohydrate sulfotransferase 3 "GO:0000139,GO:0001517,GO:0005802,GO:0005975,GO:0006044,GO:0006790,GO:0008146,GO:0008459,GO:0016021,GO:0030206" Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|trans-Golgi network|carbohydrate metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|sulfotransferase activity|chondroitin 6-sulfotransferase activity|integral component of membrane|chondroitin sulfate biosynthetic process hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST6 9.04552906 12.17947162 5.911586499 0.485372985 -1.042834281 0.499104294 1 0.066910432 0.033875473 4166 carbohydrate sulfotransferase 6 "GO:0000139,GO:0001517,GO:0005794,GO:0005802,GO:0005975,GO:0006044,GO:0006790,GO:0016021,GO:0018146" Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|Golgi apparatus|trans-Golgi network|carbohydrate metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|integral component of membrane|keratan sulfate biosynthetic process hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate CHST7 148.2214277 197.9164138 98.52644165 0.497818446 -1.006308405 0.091830572 1 4.183542635 2.172356582 56548 carbohydrate sulfotransferase 7 "GO:0000139,GO:0001517,GO:0005802,GO:0005976,GO:0006044,GO:0006790,GO:0008459,GO:0016021,GO:0030206" Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|trans-Golgi network|polysaccharide metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|chondroitin 6-sulfotransferase activity|integral component of membrane|chondroitin sulfate biosynthetic process hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST9 4.52276453 6.08973581 2.95579325 0.485372985 -1.042834281 0.660953233 1 0.02622204 0.013275718 83539 carbohydrate sulfotransferase 9 "GO:0000139,GO:0001537,GO:0005576,GO:0006790,GO:0008146,GO:0016021,GO:0016051,GO:0030166,GO:0030203,GO:0030206,GO:0042446" Golgi membrane|N-acetylgalactosamine 4-O-sulfotransferase activity|extracellular region|sulfur compound metabolic process|sulfotransferase activity|integral component of membrane|carbohydrate biosynthetic process|proteoglycan biosynthetic process|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|hormone biosynthetic process hsa00513 Various types of N-glycan biosynthesis CHSY1 1773.471752 2256.247118 1290.696386 0.572054531 -0.805775418 0.013714207 0.521881214 23.07105935 13.7664162 22856 chondroitin sulfate synthase 1 "GO:0000139,GO:0002063,GO:0005576,GO:0008376,GO:0009954,GO:0016020,GO:0016021,GO:0030206,GO:0030279,GO:0031667,GO:0032580,GO:0045880,GO:0046872,GO:0047238,GO:0050510,GO:0051923,GO:0060349" Golgi membrane|chondrocyte development|extracellular region|acetylgalactosaminyltransferase activity|proximal/distal pattern formation|membrane|integral component of membrane|chondroitin sulfate biosynthetic process|negative regulation of ossification|response to nutrient levels|Golgi cisterna membrane|positive regulation of smoothened signaling pathway|metal ion binding|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|sulfation|bone morphogenesis hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHSY3 134.0714273 173.5574706 94.58538399 0.544980194 -0.875724295 0.155209675 1 0.455255522 0.25879261 337876 chondroitin sulfate synthase 3 "GO:0000139,GO:0008376,GO:0016021,GO:0030206,GO:0032580,GO:0046872,GO:0047238,GO:0050510" Golgi membrane|acetylgalactosaminyltransferase activity|integral component of membrane|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHTF18 485.7148223 436.4310664 534.9985782 1.225848981 0.293781257 0.476634873 1 7.109583106 9.090693919 63922 chromosome transmission fidelity factor 18 "GO:0003677,GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0007049,GO:0016020,GO:0017116,GO:0031390,GO:0032508,GO:1900264" DNA binding|DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA replication|cell cycle|membrane|single-stranded DNA helicase activity|Ctf18 RFC-like complex|DNA duplex unwinding|positive regulation of DNA-directed DNA polymerase activity CHTOP 1887.553345 2073.555043 1701.551647 0.820596325 -0.285255402 0.378310571 1 50.44104125 43.17472105 26097 chromatin target of PRMT1 "GO:0000346,GO:0001701,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006405,GO:0006406,GO:0008284,GO:0008327,GO:0016607,GO:0031062,GO:0031124,GO:0032781,GO:0036464,GO:0051096" transcription export complex|in utero embryonic development|RNA binding|protein binding|nucleoplasm|nucleolus|RNA export from nucleus|mRNA export from nucleus|positive regulation of cell population proliferation|methyl-CpG binding|nuclear speck|positive regulation of histone methylation|mRNA 3'-end processing|positive regulation of ATPase activity|cytoplasmic ribonucleoprotein granule|positive regulation of helicase activity CHUK 2075.038376 2059.34566 2090.731092 1.015240488 0.02182151 0.947445971 1 14.4778724 15.33167496 1147 component of inhibitor of nuclear factor kappa B kinase complex "GO:0002223,GO:0002479,GO:0002756,GO:0003009,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006954,GO:0006955,GO:0007249,GO:0007252,GO:0007266,GO:0008384,GO:0008385,GO:0009615,GO:0009636,GO:0009653,GO:0009898,GO:0010034,GO:0010803,GO:0018105,GO:0032088,GO:0032496,GO:0032727,GO:0033194,GO:0033209,GO:0034614,GO:0035631,GO:0035666,GO:0038061,GO:0038095,GO:0042493,GO:0042803,GO:0043123,GO:0043200,GO:0044877,GO:0045087,GO:0045893,GO:0045944,GO:0046982,GO:0050852,GO:0051092,GO:0051146,GO:0051403,GO:0061847,GO:0070498,GO:0071276,GO:0071356,GO:0097110,GO:0098586,GO:1990459" "stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|MyD88-independent toll-like receptor signaling pathway|skeletal muscle contraction|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|inflammatory response|immune response|I-kappaB kinase/NF-kappaB signaling|I-kappaB phosphorylation|Rho protein signal transduction|IkappaB kinase activity|IkappaB kinase complex|response to virus|response to toxic substance|anatomical structure morphogenesis|cytoplasmic side of plasma membrane|response to acetate|regulation of tumor necrosis factor-mediated signaling pathway|peptidyl-serine phosphorylation|negative regulation of NF-kappaB transcription factor activity|response to lipopolysaccharide|positive regulation of interferon-alpha production|response to hydroperoxide|tumor necrosis factor-mediated signaling pathway|cellular response to reactive oxygen species|CD40 receptor complex|TRIF-dependent toll-like receptor signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|response to drug|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to amino acid|protein-containing complex binding|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|striated muscle cell differentiation|stress-activated MAPK cascade|response to cholecystokinin|interleukin-1-mediated signaling pathway|cellular response to cadmium ion|cellular response to tumor necrosis factor|scaffold protein binding|cellular response to virus|transferrin receptor binding" "hsa01523,hsa04010,hsa04014,hsa04062,hsa04064,hsa04068,hsa04150,hsa04151,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04920,hsa05010,hsa05120,hsa05130,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05235,hsa05418" Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Alzheimer disease|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis CHURC1 454.8071619 512.552764 397.0615599 0.774674507 -0.36833783 0.379636475 1 7.372618381 5.957402577 91612 churchill domain containing 1 "GO:0005515,GO:0007275,GO:0008270,GO:0045893" "protein binding|multicellular organism development|zinc ion binding|positive regulation of transcription, DNA-templated" CIAO1 1388.947938 1362.07091 1415.824967 1.039464948 0.055841109 0.869485628 1 17.10066596 18.54124114 9391 cytosolic iron-sulfur assembly component 1 "GO:0005515,GO:0005737,GO:0006357,GO:0007059,GO:0008284,GO:0016226,GO:0071817,GO:0097361,GO:0097428" protein binding|cytoplasm|regulation of transcription by RNA polymerase II|chromosome segregation|positive regulation of cell population proliferation|iron-sulfur cluster assembly|MMXD complex|CIA complex|protein maturation by iron-sulfur cluster transfer CIAO2A 569.3177993 561.2706505 577.3649481 1.028674754 0.040786903 0.922430348 1 30.93185898 33.18944824 84191 cytosolic iron-sulfur assembly component 2A "GO:0005515,GO:0005654,GO:0005829,GO:0007059,GO:0016226,GO:0046872,GO:0097361,GO:0097428,GO:0106035" protein binding|nucleoplasm|cytosol|chromosome segregation|iron-sulfur cluster assembly|metal ion binding|CIA complex|protein maturation by iron-sulfur cluster transfer|protein maturation by [4Fe-4S] cluster transfer CIAO2B 851.2179832 804.8600829 897.5758835 1.11519493 0.157295907 0.666412322 1 61.02293986 70.98389766 51647 cytosolic iron-sulfur assembly component 2B "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0007059,GO:0016226,GO:0030496,GO:0071817,GO:0097361,GO:0097428,GO:0106035" protein binding|nucleus|nucleoplasm|cytoplasm|spindle|cytosol|chromosome segregation|iron-sulfur cluster assembly|midbody|MMXD complex|CIA complex|protein maturation by iron-sulfur cluster transfer|protein maturation by [4Fe-4S] cluster transfer CIAO3 318.0201954 321.741042 314.2993489 0.976870551 -0.033760698 0.949242917 1 7.485093588 7.626937401 64428 cytosolic iron-sulfur assembly component 3 "GO:0001666,GO:0002244,GO:0005515,GO:0010468,GO:0016226,GO:0032364,GO:0046872,GO:0051539,GO:0097361" "response to hypoxia|hematopoietic progenitor cell differentiation|protein binding|regulation of gene expression|iron-sulfur cluster assembly|oxygen homeostasis|metal ion binding|4 iron, 4 sulfur cluster binding|CIA complex" CIAPIN1 759.2293722 813.9946866 704.4640578 0.86544061 -0.208493276 0.575736821 1 20.39879232 18.41440354 57019 cytokine induced apoptosis inhibitor 1 "GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005758,GO:0006915,GO:0008168,GO:0009055,GO:0016226,GO:0022900,GO:0030097,GO:0043066,GO:0046872,GO:0051537,GO:0051539" "protein binding|nucleoplasm|nucleolus|cytoplasm|mitochondrion|mitochondrial intermembrane space|apoptotic process|methyltransferase activity|electron transfer activity|iron-sulfur cluster assembly|electron transport chain|hemopoiesis|negative regulation of apoptotic process|metal ion binding|2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding" CIART 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.127080196 0.096507411 148523 circadian associated repressor of transcription "GO:0000978,GO:0005515,GO:0005634,GO:0016605,GO:0032922,GO:0045475,GO:0045892,GO:0070888" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|protein binding|nucleus|PML body|circadian regulation of gene expression|locomotor rhythm|negative regulation of transcription, DNA-templated|E-box binding" CIB1 2867.655891 3135.198986 2600.112795 0.829329432 -0.269982802 0.396427653 1 111.664394 96.59568391 10519 calcium and integrin binding 1 "GO:0001525,GO:0001933,GO:0001934,GO:0001954,GO:0002931,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005794,GO:0005813,GO:0005886,GO:0006302,GO:0006915,GO:0006974,GO:0007026,GO:0007113,GO:0007155,GO:0007286,GO:0008022,GO:0008284,GO:0008285,GO:0008427,GO:0010977,GO:0016020,GO:0016324,GO:0019901,GO:0030027,GO:0030220,GO:0030291,GO:0030307,GO:0030335,GO:0030425,GO:0030426,GO:0031122,GO:0031267,GO:0031982,GO:0032433,GO:0032587,GO:0033630,GO:0038163,GO:0042127,GO:0042383,GO:0043005,GO:0043025,GO:0043066,GO:0043085,GO:0043204,GO:0043495,GO:0044325,GO:0045653,GO:0048471,GO:0051092,GO:0051301,GO:0051302,GO:0051898,GO:0070062,GO:0070374,GO:0070886,GO:0071356,GO:0071363,GO:0071901,GO:0071902,GO:0071944,GO:0090050,GO:0090314,GO:0097191,GO:1900026,GO:1903078,GO:1990090,GO:2000256" angiogenesis|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of cell-matrix adhesion|response to ischemia|calcium ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|Golgi apparatus|centrosome|plasma membrane|double-strand break repair|apoptotic process|cellular response to DNA damage stimulus|negative regulation of microtubule depolymerization|endomitotic cell cycle|cell adhesion|spermatid development|protein C-terminus binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|calcium-dependent protein kinase inhibitor activity|negative regulation of neuron projection development|membrane|apical plasma membrane|protein kinase binding|lamellipodium|platelet formation|protein serine/threonine kinase inhibitor activity|positive regulation of cell growth|positive regulation of cell migration|dendrite|growth cone|cytoplasmic microtubule organization|small GTPase binding|vesicle|filopodium tip|ruffle membrane|positive regulation of cell adhesion mediated by integrin|thrombopoietin-mediated signaling pathway|regulation of cell population proliferation|sarcolemma|neuron projection|neuronal cell body|negative regulation of apoptotic process|positive regulation of catalytic activity|perikaryon|protein-membrane adaptor activity|ion channel binding|negative regulation of megakaryocyte differentiation|perinuclear region of cytoplasm|positive regulation of NF-kappaB transcription factor activity|cell division|regulation of cell division|negative regulation of protein kinase B signaling|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|positive regulation of calcineurin-NFAT signaling cascade|cellular response to tumor necrosis factor|cellular response to growth factor stimulus|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|cell periphery|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of protein targeting to membrane|extrinsic apoptotic signaling pathway|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of protein localization to plasma membrane|cellular response to nerve growth factor stimulus|positive regulation of male germ cell proliferation CIB2 267.8513823 259.8287279 275.8740366 1.061753405 0.086448736 0.867028432 1 5.24279221 5.806336987 10518 calcium and integrin binding family member 2 "GO:0000287,GO:0001750,GO:0001917,GO:0005509,GO:0005515,GO:0005737,GO:0007204,GO:0032420,GO:0032437,GO:0042383,GO:0042803,GO:0045494,GO:0055074,GO:0071318,GO:0072562" magnesium ion binding|photoreceptor outer segment|photoreceptor inner segment|calcium ion binding|protein binding|cytoplasm|positive regulation of cytosolic calcium ion concentration|stereocilium|cuticular plate|sarcolemma|protein homodimerization activity|photoreceptor cell maintenance|calcium ion homeostasis|cellular response to ATP|blood microparticle CIBAR1 552.469827 487.1788648 617.7607892 1.268036924 0.342596756 0.390800007 1 5.87753474 7.773973117 137392 CBY1 interacting BAR domain containing 1 "GO:0005515,GO:0005543,GO:0005634,GO:0005737,GO:0005743,GO:0005814,GO:0007007,GO:0035108,GO:0035869,GO:0036064,GO:0045880,GO:0060271,GO:0061024,GO:0097546" protein binding|phospholipid binding|nucleus|cytoplasm|mitochondrial inner membrane|centriole|inner mitochondrial membrane organization|limb morphogenesis|ciliary transition zone|ciliary basal body|positive regulation of smoothened signaling pathway|cilium assembly|membrane organization|ciliary base CIC 1864.750733 1794.442152 1935.059314 1.078362605 0.108842374 0.737944481 1 10.4860003 11.79480091 23152 capicua transcriptional repressor "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007420,GO:0007612,GO:0007613,GO:0035176,GO:0043231,GO:0045892" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|brain development|learning|memory|social behavior|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated" hsa05017 Spinocerebellar ataxia CILK1 406.5643403 447.5955821 365.5330985 0.816659309 -0.29219375 0.500037931 1 3.259401468 2.776480983 22858 ciliogenesis associated kinase 1 "GO:0000165,GO:0000287,GO:0001650,GO:0004672,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005929,GO:0006468,GO:0007165,GO:0007275,GO:0010468,GO:0035556,GO:0035720,GO:0035721,GO:0036064,GO:0042073,GO:0060271,GO:0097542,GO:0097546,GO:0106310,GO:0106311" MAPK cascade|magnesium ion binding|fibrillar center|protein kinase activity|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cilium|protein phosphorylation|signal transduction|multicellular organism development|regulation of gene expression|intracellular signal transduction|intraciliary anterograde transport|intraciliary retrograde transport|ciliary basal body|intraciliary transport|cilium assembly|ciliary tip|ciliary base|protein serine kinase activity|protein threonine kinase activity CILP2 88.33902561 78.15160956 98.52644165 1.260709053 0.334235368 0.64433276 1 0.942629989 1.239572844 148113 cartilage intermediate layer protein 2 "GO:0004035,GO:0004551,GO:0016311,GO:0070062" alkaline phosphatase activity|nucleotide diphosphatase activity|dephosphorylation|extracellular exosome CINP 361.4851528 396.8477836 326.1225219 0.821782394 -0.283171672 0.528015099 1 21.09017864 18.07810985 51550 cyclin dependent kinase 2 interacting protein "GO:0005515,GO:0005634,GO:0006260,GO:0006281,GO:0007049,GO:0051301" protein binding|nucleus|DNA replication|DNA repair|cell cycle|cell division CIP2A 1364.297523 1226.06681 1502.528235 1.225486428 0.293354507 0.382404614 1 7.52495863 9.618969602 57650 cellular inhibitor of PP2A "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0016021,GO:0042803,GO:0045296" protein binding|cytoplasm|cytosol|plasma membrane|integral component of membrane|protein homodimerization activity|cadherin binding CIPC 483.5607009 491.2386887 475.8827132 0.968740297 -0.04581814 0.916507623 1 5.752487074 5.812713889 85457 CLOCK interacting pacemaker "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0042754,GO:0045892,GO:0048511" "protein binding|nucleus|nucleoplasm|nucleolus|cytosol|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|rhythmic process" CIR1 263.1059311 238.5146526 287.6972096 1.206203504 0.270473331 0.586578245 1 6.298188594 7.924140669 9541 "corepressor interacting with RBPJ, CIR1" "GO:0000122,GO:0001701,GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0006397,GO:0008380,GO:0016607,GO:0019901,GO:0032991,GO:0042826,GO:0044877,GO:0045892" "negative regulation of transcription by RNA polymerase II|in utero embryonic development|transcription corepressor activity|protein binding|nucleus|cytoplasm|centrosome|mRNA processing|RNA splicing|nuclear speck|protein kinase binding|protein-containing complex|histone deacetylase binding|protein-containing complex binding|negative regulation of transcription, DNA-templated" "hsa04330,hsa05169" Notch signaling pathway|Epstein-Barr virus infection CIRBP 1719.196102 1846.204906 1592.187297 0.862410934 -0.213552626 0.513430161 1 38.87890457 34.97391125 1153 cold inducible RNA binding protein "GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0009409,GO:0009411,GO:0010494,GO:0017148,GO:0030371,GO:0034063,GO:0045727,GO:0048026,GO:0048255,GO:0070181" "RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|response to cold|response to UV|cytoplasmic stress granule|negative regulation of translation|translation repressor activity|stress granule assembly|positive regulation of translation|positive regulation of mRNA splicing, via spliceosome|mRNA stabilization|small ribosomal subunit rRNA binding" CISD1 308.1796754 356.2495449 260.109806 0.730133721 -0.453767382 0.33381182 1 7.596961127 5.785731039 55847 CDGSH iron sulfur domain 1 "GO:0005739,GO:0005741,GO:0016021,GO:0032473,GO:0042802,GO:0043457,GO:0046872,GO:0051537" "mitochondrion|mitochondrial outer membrane|integral component of membrane|cytoplasmic side of mitochondrial outer membrane|identical protein binding|regulation of cellular respiration|metal ion binding|2 iron, 2 sulfur cluster binding" CISD2 847.4550748 817.0395545 877.8705951 1.074452993 0.103602367 0.777855881 1 7.039838567 7.889801014 493856 CDGSH iron sulfur domain 2 "GO:0000422,GO:0003723,GO:0005515,GO:0005741,GO:0005783,GO:0005789,GO:0010259,GO:0010506,GO:0016020,GO:0016021,GO:0032991,GO:0042803,GO:0046872,GO:0051537,GO:0097038" "autophagy of mitochondrion|RNA binding|protein binding|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|multicellular organism aging|regulation of autophagy|membrane|integral component of membrane|protein-containing complex|protein homodimerization activity|metal ion binding|2 iron, 2 sulfur cluster binding|perinuclear endoplasmic reticulum" CISD3 562.0970629 505.4480723 618.7460536 1.224153553 0.291784536 0.463389078 1 10.03101949 12.80845956 284106 CDGSH iron sulfur domain 3 "GO:0005739,GO:0046872,GO:0051537,GO:0106034" "mitochondrion|metal ion binding|2 iron, 2 sulfur cluster binding|protein maturation by [2Fe-2S] cluster transfer" CISH 5.463491619 3.044867905 7.882115332 2.588655921 1.372203218 0.484534422 1 0.069747543 0.188329855 1154 cytokine inducible SH2 containing protein "GO:0001558,GO:0003674,GO:0005515,GO:0005575,GO:0005829,GO:0005886,GO:0005942,GO:0007205,GO:0009968,GO:0016567,GO:0035556,GO:0038111,GO:0043551,GO:0043687,GO:0046854,GO:0046935" regulation of cell growth|molecular_function|protein binding|cellular_component|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|protein kinase C-activating G protein-coupled receptor signaling pathway|negative regulation of signal transduction|protein ubiquitination|intracellular signal transduction|interleukin-7-mediated signaling pathway|regulation of phosphatidylinositol 3-kinase activity|post-translational protein modification|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity "hsa04630,hsa04917" JAK-STAT signaling pathway|Prolactin signaling pathway CIT 2686.285583 2119.228062 3253.343103 1.535154787 0.618384127 0.052824563 1 10.75141993 17.21606627 11113 citron rho-interacting serine/threonine kinase "GO:0000278,GO:0000281,GO:0001223,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005856,GO:0016020,GO:0017124,GO:0018107,GO:0019901,GO:0030165,GO:0030291,GO:0031032,GO:0032467,GO:0035331,GO:0035556,GO:0046872,GO:0048699,GO:0051402,GO:0071901,GO:0097110,GO:0106310,GO:0106311" mitotic cell cycle|mitotic cytokinesis|transcription coactivator binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|cytoskeleton|membrane|SH3 domain binding|peptidyl-threonine phosphorylation|protein kinase binding|PDZ domain binding|protein serine/threonine kinase inhibitor activity|actomyosin structure organization|positive regulation of cytokinesis|negative regulation of hippo signaling|intracellular signal transduction|metal ion binding|generation of neurons|neuron apoptotic process|negative regulation of protein serine/threonine kinase activity|scaffold protein binding|protein serine kinase activity|protein threonine kinase activity CITED1 11.075441 16.23929549 5.911586499 0.364029739 -1.457871781 0.291645288 1 0.566044754 0.214933229 4435 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 "GO:0000578,GO:0001570,GO:0001656,GO:0001658,GO:0001890,GO:0003340,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006913,GO:0006915,GO:0007179,GO:0007420,GO:0008022,GO:0010628,GO:0030178,GO:0030318,GO:0030511,GO:0032496,GO:0032868,GO:0034097,GO:0034341,GO:0042438,GO:0042803,GO:0042981,GO:0043473,GO:0043524,GO:0043627,GO:0045668,GO:0045892,GO:0045893,GO:0045944,GO:0050693,GO:0051591,GO:0060231,GO:0060395,GO:0060711,GO:0070410,GO:0070555,GO:0070669,GO:0070670,GO:0070741,GO:0071104,GO:0071105,GO:0071107,GO:0071559,GO:1902462" "embryonic axis specification|vasculogenesis|metanephros development|branching involved in ureteric bud morphogenesis|placenta development|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|nucleocytoplasmic transport|apoptotic process|transforming growth factor beta receptor signaling pathway|brain development|protein C-terminus binding|positive regulation of gene expression|negative regulation of Wnt signaling pathway|melanocyte differentiation|positive regulation of transforming growth factor beta receptor signaling pathway|response to lipopolysaccharide|response to insulin|response to cytokine|response to interferon-gamma|melanin biosynthetic process|protein homodimerization activity|regulation of apoptotic process|pigmentation|negative regulation of neuron apoptotic process|response to estrogen|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|LBD domain binding|response to cAMP|mesenchymal to epithelial transition|SMAD protein signal transduction|labyrinthine layer development|co-SMAD binding|response to interleukin-1|response to interleukin-2|response to interleukin-4|response to interleukin-6|response to interleukin-9|response to interleukin-11|response to parathyroid hormone|response to transforming growth factor beta|positive regulation of mesenchymal stem cell proliferation" CITED2 963.0249594 1241.291149 684.7587695 0.551650408 -0.858173802 0.016022684 0.5587138 24.52868424 14.11413042 10370 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 "GO:0000122,GO:0000785,GO:0001666,GO:0001889,GO:0003151,GO:0003156,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0007368,GO:0007507,GO:0007530,GO:0008283,GO:0010628,GO:0010629,GO:0019904,GO:0022409,GO:0030154,GO:0030336,GO:0030511,GO:0032991,GO:0034405,GO:0035035,GO:0035360,GO:0035802,GO:0043066,GO:0043627,GO:0045787,GO:0045892,GO:0045893,GO:0045944,GO:0048536,GO:0050693,GO:0060412,GO:0060971,GO:0060972,GO:0061428,GO:0070986,GO:1900164,GO:2000020" "negative regulation of transcription by RNA polymerase II|chromatin|response to hypoxia|liver development|outflow tract morphogenesis|regulation of animal organ formation|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|determination of left/right symmetry|heart development|sex determination|cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|protein domain specific binding|positive regulation of cell-cell adhesion|cell differentiation|negative regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|protein-containing complex|response to fluid shear stress|histone acetyltransferase binding|positive regulation of peroxisome proliferator activated receptor signaling pathway|adrenal cortex formation|negative regulation of apoptotic process|response to estrogen|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|spleen development|LBD domain binding|ventricular septum morphogenesis|embryonic heart tube left/right pattern formation|left/right pattern formation|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|left/right axis specification|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|positive regulation of male gonad development" hsa04137 Mitophagy - animal CITED4 241.2343972 258.8137719 223.6550226 0.864154256 -0.210639231 0.682620966 1 10.00611031 9.019292871 163732 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 "GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0043627,GO:0045944" transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|response to estrogen|positive regulation of transcription by RNA polymerase II CIZ1 3054.898192 2801.278473 3308.517911 1.181074264 0.240099682 0.450538212 1 39.58562286 48.76751415 25792 CDKN1A interacting zinc finger protein 1 "GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0008270" nucleic acid binding|protein binding|nucleus|nucleoplasm|plasma membrane|zinc ion binding CKAP2 1816.358216 1550.85272 2081.863712 1.342399369 0.424813943 0.191068898 1 20.35905111 28.50724194 26586 cytoskeleton associated protein 2 "GO:0000281,GO:0000922,GO:0005813,GO:0005829,GO:0005874,GO:0006915,GO:0015630,GO:0045944" mitotic cytokinesis|spindle pole|centrosome|cytosol|microtubule|apoptotic process|microtubule cytoskeleton|positive regulation of transcription by RNA polymerase II CKAP2L 1538.666314 1325.532495 1751.800133 1.321582187 0.402266146 0.223720795 1 14.19013838 19.56125599 150468 cytoskeleton associated protein 2 like "GO:0000922,GO:0005813,GO:0005829,GO:0072686" spindle pole|centrosome|cytosol|mitotic spindle CKAP4 6364.622584 7060.033716 5669.211453 0.80300062 -0.316526993 0.331073669 1 114.5677031 95.96083466 10970 cytoskeleton associated protein 4 "GO:0003723,GO:0005783,GO:0005788,GO:0005789,GO:0005791,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0016020,GO:0016021,GO:0016607,GO:0035577,GO:0035579,GO:0036464,GO:0042599,GO:0043312,GO:0043687,GO:0044267,GO:0048471,GO:0070062" RNA binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|rough endoplasmic reticulum|lipid droplet|cytosol|cytoskeleton|plasma membrane|membrane|integral component of membrane|nuclear speck|azurophil granule membrane|specific granule membrane|cytoplasmic ribonucleoprotein granule|lamellar body|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|perinuclear region of cytoplasm|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum CKAP5 8511.56472 7535.033109 9488.096331 1.259197696 0.332504806 0.317000284 1 53.21010108 69.8882127 9793 cytoskeleton associated protein 5 "GO:0000086,GO:0000776,GO:0000777,GO:0000922,GO:0000930,GO:0005515,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0007019,GO:0007051,GO:0007052,GO:0007098,GO:0008017,GO:0010389,GO:0015630,GO:0016020,GO:0030951,GO:0032991,GO:0035371,GO:0043021,GO:0045296,GO:0046785,GO:0050658,GO:0051298,GO:0051301,GO:0061863,GO:0090063,GO:0097711" G2/M transition of mitotic cell cycle|kinetochore|condensed chromosome kinetochore|spindle pole|gamma-tubulin complex|protein binding|nucleolus|cytoplasm|centrosome|cytosol|plasma membrane|microtubule depolymerization|spindle organization|mitotic spindle organization|centrosome cycle|microtubule binding|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|membrane|establishment or maintenance of microtubule cytoskeleton polarity|protein-containing complex|microtubule plus-end|ribonucleoprotein complex binding|cadherin binding|microtubule polymerization|RNA transport|centrosome duplication|cell division|microtubule plus end polymerase|positive regulation of microtubule nucleation|ciliary basal body-plasma membrane docking CKB 229.5178663 232.4249168 226.6108158 0.974985036 -0.036548018 0.952510598 1 8.272313484 8.412805799 1152 creatine kinase B "GO:0004111,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005829,GO:0006600,GO:0016301,GO:0016310,GO:0021549,GO:0021762,GO:0030425,GO:0030644,GO:0031625,GO:0043025,GO:0046314,GO:0070062" creatine kinase activity|protein binding|ATP binding|extracellular space|nucleus|cytosol|creatine metabolic process|kinase activity|phosphorylation|cerebellum development|substantia nigra development|dendrite|cellular chloride ion homeostasis|ubiquitin protein ligase binding|neuronal cell body|phosphocreatine biosynthetic process|extracellular exosome hsa00330 Arginine and proline metabolism CKLF 23.89872419 17.25425146 30.54319691 1.770183829 0.823899188 0.444921737 1 0.999847789 1.84615512 51192 chemokine like factor "GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0008009,GO:0016020,GO:0016021,GO:0030593,GO:0032940,GO:0048246,GO:0048247" protein binding|extracellular region|extracellular space|signal transduction|chemokine activity|membrane|integral component of membrane|neutrophil chemotaxis|secretion by cell|macrophage chemotaxis|lymphocyte chemotaxis CKMT1A 3.941057666 0 7.882115332 Inf Inf 0.07384143 1 0 0.17386109 548596 "creatine kinase, mitochondrial 1A" "GO:0004111,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0006600,GO:0016301,GO:0016310,GO:0046314" creatine kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|creatine metabolic process|kinase activity|phosphorylation|phosphocreatine biosynthetic process hsa00330 Arginine and proline metabolism CKS1B 2045.376769 1681.78204 2408.971498 1.432392214 0.518426581 0.107558181 1 109.3405999 163.3651191 1163 CDC28 protein kinase regulatory subunit 1B "GO:0000307,GO:0005515,GO:0005654,GO:0006355,GO:0007346,GO:0008283,GO:0019005,GO:0019901,GO:0042393,GO:0043130,GO:0044772,GO:0045737,GO:0051301,GO:0061575" "cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of mitotic cell cycle|cell population proliferation|SCF ubiquitin ligase complex|protein kinase binding|histone binding|ubiquitin binding|mitotic cell cycle phase transition|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|cyclin-dependent protein serine/threonine kinase activator activity" "hsa05200,hsa05222" Pathways in cancer|Small cell lung cancer CKS2 1932.478878 1810.681448 2054.276308 1.134532146 0.182097487 0.573497877 1 148.8711487 176.1745923 1164 CDC28 protein kinase regulatory subunit 2 "GO:0000307,GO:0003682,GO:0005515,GO:0006357,GO:0007127,GO:0007346,GO:0008283,GO:0019005,GO:0019901,GO:0042393,GO:0043130,GO:0044772,GO:0045737,GO:0051301,GO:0061575" cyclin-dependent protein kinase holoenzyme complex|chromatin binding|protein binding|regulation of transcription by RNA polymerase II|meiosis I|regulation of mitotic cell cycle|cell population proliferation|SCF ubiquitin ligase complex|protein kinase binding|histone binding|ubiquitin binding|mitotic cell cycle phase transition|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|cyclin-dependent protein serine/threonine kinase activator activity "hsa05200,hsa05222" Pathways in cancer|Small cell lung cancer CLASP1 1271.274904 1467.62633 1074.923478 0.732423135 -0.449250732 0.185382982 1 6.002107248 4.585447602 23332 cytoplasmic linker associated protein 1 "GO:0000086,GO:0000226,GO:0000776,GO:0000777,GO:0001578,GO:0002162,GO:0005515,GO:0005794,GO:0005813,GO:0005815,GO:0005828,GO:0005829,GO:0005876,GO:0005881,GO:0005925,GO:0005938,GO:0006903,GO:0007020,GO:0007026,GO:0007030,GO:0007052,GO:0007163,GO:0008017,GO:0010389,GO:0010458,GO:0010470,GO:0010634,GO:0010717,GO:0016020,GO:0030953,GO:0030981,GO:0031023,GO:0031110,GO:0031111,GO:0031116,GO:0031592,GO:0034453,GO:0035371,GO:0040001,GO:0043515,GO:0045180,GO:0045921,GO:0051010,GO:0051294,GO:0051301,GO:0051497,GO:0051893,GO:0070507,GO:0072686,GO:0090091,GO:0090162,GO:0090307,GO:0097711,GO:1903690,GO:1904261" "G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|kinetochore|condensed chromosome kinetochore|microtubule bundle formation|dystroglycan binding|protein binding|Golgi apparatus|centrosome|microtubule organizing center|kinetochore microtubule|cytosol|spindle microtubule|cytoplasmic microtubule|focal adhesion|cell cortex|vesicle targeting|microtubule nucleation|negative regulation of microtubule depolymerization|Golgi organization|mitotic spindle organization|establishment or maintenance of cell polarity|microtubule binding|regulation of G2/M transition of mitotic cell cycle|exit from mitosis|regulation of gastrulation|positive regulation of epithelial cell migration|regulation of epithelial to mesenchymal transition|membrane|astral microtubule organization|cortical microtubule cytoskeleton|microtubule organizing center organization|regulation of microtubule polymerization or depolymerization|negative regulation of microtubule polymerization or depolymerization|positive regulation of microtubule polymerization|centrosomal corona|microtubule anchoring|microtubule plus-end|establishment of mitotic spindle localization|kinetochore binding|basal cortex|positive regulation of exocytosis|microtubule plus-end binding|establishment of spindle orientation|cell division|negative regulation of stress fiber assembly|regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|mitotic spindle|positive regulation of extracellular matrix disassembly|establishment of epithelial cell polarity|mitotic spindle assembly|ciliary basal body-plasma membrane docking|negative regulation of wound healing, spreading of epidermal cells|positive regulation of basement membrane assembly involved in embryonic body morphogenesis" CLASP2 1987.337719 2024.837157 1949.83828 0.962960539 -0.054451415 0.867245321 1 13.48998406 13.54989272 23122 cytoplasmic linker associated protein 2 "GO:0000226,GO:0000776,GO:0000777,GO:0002162,GO:0005515,GO:0005737,GO:0005794,GO:0005802,GO:0005815,GO:0005828,GO:0005829,GO:0005874,GO:0005876,GO:0005881,GO:0005886,GO:0005925,GO:0005938,GO:0006903,GO:0007020,GO:0007026,GO:0007030,GO:0007052,GO:0007163,GO:0008017,GO:0010458,GO:0010470,GO:0010634,GO:0010717,GO:0016020,GO:0031023,GO:0031110,GO:0031252,GO:0032587,GO:0032886,GO:0034453,GO:0040001,GO:0045180,GO:0045921,GO:0051010,GO:0051301,GO:0051497,GO:0051895,GO:0072659,GO:0072686,GO:0090091,GO:0090307,GO:1903690,GO:1904261" "microtubule cytoskeleton organization|kinetochore|condensed chromosome kinetochore|dystroglycan binding|protein binding|cytoplasm|Golgi apparatus|trans-Golgi network|microtubule organizing center|kinetochore microtubule|cytosol|microtubule|spindle microtubule|cytoplasmic microtubule|plasma membrane|focal adhesion|cell cortex|vesicle targeting|microtubule nucleation|negative regulation of microtubule depolymerization|Golgi organization|mitotic spindle organization|establishment or maintenance of cell polarity|microtubule binding|exit from mitosis|regulation of gastrulation|positive regulation of epithelial cell migration|regulation of epithelial to mesenchymal transition|membrane|microtubule organizing center organization|regulation of microtubule polymerization or depolymerization|cell leading edge|ruffle membrane|regulation of microtubule-based process|microtubule anchoring|establishment of mitotic spindle localization|basal cortex|positive regulation of exocytosis|microtubule plus-end binding|cell division|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly|protein localization to plasma membrane|mitotic spindle|positive regulation of extracellular matrix disassembly|mitotic spindle assembly|negative regulation of wound healing, spreading of epidermal cells|positive regulation of basement membrane assembly involved in embryonic body morphogenesis" CLASRP 504.7587317 492.2536447 517.2638187 1.050807494 0.071498394 0.865196487 1 10.88210848 11.92757462 11129 CLK4 associating serine/arginine rich protein "GO:0005515,GO:0005654,GO:0006397,GO:0008380" protein binding|nucleoplasm|mRNA processing|RNA splicing CLBA1 222.9651898 222.2753571 223.6550226 1.006207011 0.008927146 0.996185311 1 2.32304224 2.438149744 122616 clathrin binding box of aftiphilin containing 1 "GO:0030121,GO:0030276,GO:0032588,GO:0046907" AP-1 adaptor complex|clathrin binding|trans-Golgi network membrane|intracellular transport CLCC1 697.2873666 688.1401466 706.4345867 1.02658534 0.037853564 0.924087667 1 6.741174238 7.218493013 23155 chloride channel CLIC like 1 "GO:0000139,GO:0005254,GO:0005515,GO:0005783,GO:0005789,GO:0016020,GO:0031965,GO:0034707,GO:0043231,GO:0044233,GO:1902476" Golgi membrane|chloride channel activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|nuclear membrane|chloride channel complex|intracellular membrane-bounded organelle|mitochondria-associated endoplasmic reticulum membrane|chloride transmembrane transport CLCF1 183.2482951 133.9741878 232.5224023 1.735576129 0.795414649 0.15227686 1 3.695708051 6.690479649 23529 cardiotrophin like cytokine factor 1 "GO:0002639,GO:0005102,GO:0005125,GO:0005127,GO:0005515,GO:0005576,GO:0007166,GO:0007259,GO:0008083,GO:0008284,GO:0019221,GO:0030183,GO:0030890,GO:0042531,GO:0043524,GO:0048295,GO:0048711,GO:0097058,GO:0097059" positive regulation of immunoglobulin production|signaling receptor binding|cytokine activity|ciliary neurotrophic factor receptor binding|protein binding|extracellular region|cell surface receptor signaling pathway|receptor signaling pathway via JAK-STAT|growth factor activity|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|B cell differentiation|positive regulation of B cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of neuron apoptotic process|positive regulation of isotype switching to IgE isotypes|positive regulation of astrocyte differentiation|CRLF-CLCF1 complex|CNTFR-CLCF1 complex hsa04060 Cytokine-cytokine receptor interaction CLCN2 163.1367276 173.5574706 152.7159846 0.879915938 -0.184562391 0.75631793 1 2.0451544 1.877081869 1181 chloride voltage-gated channel 2 "GO:0005247,GO:0005886,GO:0005887,GO:0006821,GO:0032347,GO:0034220,GO:0034707,GO:0034765,GO:0060041,GO:0060689,GO:1902476" voltage-gated chloride channel activity|plasma membrane|integral component of plasma membrane|chloride transport|regulation of aldosterone biosynthetic process|ion transmembrane transport|chloride channel complex|regulation of ion transmembrane transport|retina development in camera-type eye|cell differentiation involved in salivary gland development|chloride transmembrane transport hsa04978 Mineral absorption CLCN3 1372.823203 1573.181751 1172.464656 0.74528239 -0.424140923 0.206167427 1 15.7493785 12.24334845 1182 chloride voltage-gated channel 3 "GO:0000139,GO:0005247,GO:0005254,GO:0005515,GO:0005524,GO:0005765,GO:0005769,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0006885,GO:0006911,GO:0008021,GO:0008344,GO:0009897,GO:0009986,GO:0010008,GO:0012506,GO:0015297,GO:0015299,GO:0016020,GO:0016021,GO:0030141,GO:0030165,GO:0031410,GO:0031901,GO:0031902,GO:0032587,GO:0035249,GO:0042581,GO:0043231,GO:0043679,GO:0045335,GO:0045494,GO:0045794,GO:0048388,GO:0051932,GO:0055037,GO:0072320,GO:0097401,GO:0098978,GO:1902476,GO:1903428" "Golgi membrane|voltage-gated chloride channel activity|chloride channel activity|protein binding|ATP binding|lysosomal membrane|early endosome|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|regulation of pH|phagocytosis, engulfment|synaptic vesicle|adult locomotory behavior|external side of plasma membrane|cell surface|endosome membrane|vesicle membrane|antiporter activity|solute:proton antiporter activity|membrane|integral component of membrane|secretory granule|PDZ domain binding|cytoplasmic vesicle|early endosome membrane|late endosome membrane|ruffle membrane|synaptic transmission, glutamatergic|specific granule|intracellular membrane-bounded organelle|axon terminus|phagocytic vesicle|photoreceptor cell maintenance|negative regulation of cell volume|endosomal lumen acidification|synaptic transmission, GABAergic|recycling endosome|volume-sensitive chloride channel activity|synaptic vesicle lumen acidification|glutamatergic synapse|chloride transmembrane transport|positive regulation of reactive oxygen species biosynthetic process" CLCN4 207.7205613 257.798816 157.6423066 0.611493525 -0.709590873 0.183050248 1 1.931735548 1.23212697 1183 chloride voltage-gated channel 4 "GO:0005247,GO:0005254,GO:0005515,GO:0005524,GO:0005765,GO:0005769,GO:0005789,GO:0005794,GO:0005887,GO:0006821,GO:0008021,GO:0010008,GO:0015297,GO:0015299,GO:0031901,GO:0031902,GO:0034220,GO:0055037,GO:0055038,GO:1902476,GO:1902600" voltage-gated chloride channel activity|chloride channel activity|protein binding|ATP binding|lysosomal membrane|early endosome|endoplasmic reticulum membrane|Golgi apparatus|integral component of plasma membrane|chloride transport|synaptic vesicle|endosome membrane|antiporter activity|solute:proton antiporter activity|early endosome membrane|late endosome membrane|ion transmembrane transport|recycling endosome|recycling endosome membrane|chloride transmembrane transport|proton transmembrane transport CLCN5 277.2626125 364.3691926 190.1560324 0.52187736 -0.938217278 0.053873307 1 1.793044519 0.976057627 1184 chloride voltage-gated channel 5 "GO:0000139,GO:0005247,GO:0005254,GO:0005515,GO:0005524,GO:0005765,GO:0005769,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0006897,GO:0007588,GO:0008021,GO:0010008,GO:0015299,GO:0016020,GO:0034220,GO:0042802,GO:0045177,GO:1902476,GO:1902600" Golgi membrane|voltage-gated chloride channel activity|chloride channel activity|protein binding|ATP binding|lysosomal membrane|early endosome|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|endocytosis|excretion|synaptic vesicle|endosome membrane|solute:proton antiporter activity|membrane|ion transmembrane transport|identical protein binding|apical part of cell|chloride transmembrane transport|proton transmembrane transport CLCN6 728.2044295 680.0204988 776.3883602 1.141713171 0.191200253 0.61129764 1 6.162218518 7.338546252 1185 chloride voltage-gated channel 6 "GO:0005247,GO:0005524,GO:0005765,GO:0006821,GO:0006884,GO:0007165,GO:0009612,GO:0010008,GO:0015108,GO:0015297,GO:0016021,GO:0034220,GO:0043231,GO:1902476" voltage-gated chloride channel activity|ATP binding|lysosomal membrane|chloride transport|cell volume homeostasis|signal transduction|response to mechanical stimulus|endosome membrane|chloride transmembrane transporter activity|antiporter activity|integral component of membrane|ion transmembrane transport|intracellular membrane-bounded organelle|chloride transmembrane transport CLCN7 5.059934066 9.134603715 0.985264417 0.107860663 -3.212759283 0.136251646 1 0.102785037 0.011564022 1186 chloride voltage-gated channel 7 "GO:0005247,GO:0005254,GO:0005515,GO:0005524,GO:0005654,GO:0005765,GO:0015108,GO:0015297,GO:0016020,GO:0016021,GO:0034220,GO:0043231,GO:1902476" voltage-gated chloride channel activity|chloride channel activity|protein binding|ATP binding|nucleoplasm|lysosomal membrane|chloride transmembrane transporter activity|antiporter activity|membrane|integral component of membrane|ion transmembrane transport|intracellular membrane-bounded organelle|chloride transmembrane transport CLDN1 9401.330256 11244.69717 7557.963339 0.672135783 -0.573175383 0.087630413 1 165.2653056 115.8656327 9076 claudin 1 "GO:0001618,GO:0005198,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0005923,GO:0007155,GO:0007568,GO:0008065,GO:0009636,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0016338,GO:0030335,GO:0032496,GO:0032991,GO:0034331,GO:0035633,GO:0042538,GO:0042802,GO:0045216,GO:0045471,GO:0046718,GO:0051259,GO:0060054,GO:0061436,GO:0061772,GO:0070160,GO:0070673,GO:0070830,GO:0071284,GO:0071346,GO:0071356,GO:0071548,GO:0071560,GO:0090303,GO:0090557,GO:0097421,GO:1903348,GO:1903545" virus receptor activity|structural molecule activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|bicellular tight junction|cell adhesion|aging|establishment of blood-nerve barrier|response to toxic substance|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|positive regulation of cell migration|response to lipopolysaccharide|protein-containing complex|cell junction maintenance|maintenance of blood-brain barrier|hyperosmotic salinity response|identical protein binding|cell-cell junction organization|response to ethanol|viral entry into host cell|protein complex oligomerization|positive regulation of epithelial cell proliferation involved in wound healing|establishment of skin barrier|xenobiotic transport across blood-nerve barrier|tight junction|response to interleukin-18|bicellular tight junction assembly|cellular response to lead ion|cellular response to interferon-gamma|cellular response to tumor necrosis factor|response to dexamethasone|cellular response to transforming growth factor beta stimulus|positive regulation of wound healing|establishment of endothelial intestinal barrier|liver regeneration|positive regulation of bicellular tight junction assembly|cellular response to butyrate "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN11 5623.360307 5958.80649 5287.914124 0.88741162 -0.17232465 0.593931229 1 105.1541907 97.33468471 5010 claudin 11 "GO:0005198,GO:0005515,GO:0005811,GO:0005883,GO:0005886,GO:0005923,GO:0007155,GO:0007283,GO:0008366,GO:0016021,GO:0016338,GO:0030054,GO:0030424,GO:0042802,GO:0045178,GO:0070160,GO:0070830,GO:0120192" structural molecule activity|protein binding|lipid droplet|neurofilament|plasma membrane|bicellular tight junction|cell adhesion|spermatogenesis|axon ensheathment|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|cell junction|axon|identical protein binding|basal part of cell|tight junction|bicellular tight junction assembly|tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN12 1799.117326 1719.33541 1878.899242 1.092805529 0.128036688 0.694555419 1 24.64711947 28.09473781 9069 claudin 12 "GO:0005515,GO:0005886,GO:0005923,GO:0016021,GO:0016328,GO:0016338,GO:0035633,GO:0042802,GO:0120192" protein binding|plasma membrane|bicellular tight junction|integral component of membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|maintenance of blood-brain barrier|identical protein binding|tight junction assembly CLDN15 134.1632235 146.1536594 122.1727877 0.835920141 -0.258562972 0.681038654 1 3.513131111 3.063198054 24146 claudin 15 "GO:0005198,GO:0005886,GO:0005923,GO:0006811,GO:0007155,GO:0016021,GO:0016328,GO:0016338,GO:0042802,GO:0070830" structural molecule activity|plasma membrane|bicellular tight junction|ion transport|cell adhesion|integral component of membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|bicellular tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN16 16.68739037 29.43372308 3.941057666 0.133895996 -2.900815276 0.023993684 0.684653464 0.418739955 0.058482768 10686 claudin 16 "GO:0005198,GO:0005515,GO:0005886,GO:0005923,GO:0006875,GO:0007155,GO:0007588,GO:0015095,GO:0016021,GO:0016338,GO:0042802,GO:0070830,GO:1903830" structural molecule activity|protein binding|plasma membrane|bicellular tight junction|cellular metal ion homeostasis|cell adhesion|excretion|magnesium ion transmembrane transporter activity|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|bicellular tight junction assembly|magnesium ion transmembrane transport "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN23 71.93370498 68.00204988 75.86536007 1.115633429 0.157863069 0.850781167 1 1.594474041 1.855474123 137075 claudin 23 "GO:0005198,GO:0005515,GO:0005886,GO:0005923,GO:0007155,GO:0016021,GO:0016338,GO:0042802,GO:0070830" structural molecule activity|protein binding|plasma membrane|bicellular tight junction|cell adhesion|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|bicellular tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN3 6.582368019 12.17947162 0.985264417 0.080895498 -3.627796782 0.066549876 1 0.484181531 0.040855309 1365 claudin 3 "GO:0001666,GO:0001934,GO:0003382,GO:0004888,GO:0005198,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0005911,GO:0005923,GO:0007155,GO:0008285,GO:0010628,GO:0010629,GO:0014045,GO:0016021,GO:0016327,GO:0016328,GO:0016338,GO:0022604,GO:0030335,GO:0030336,GO:0031532,GO:0032991,GO:0034331,GO:0035633,GO:0042802,GO:0043296,GO:0045471,GO:0061045,GO:0070160,GO:0070830,GO:0090303,GO:0090559,GO:0150111,GO:1901890,GO:1903348,GO:1905050" response to hypoxia|positive regulation of protein phosphorylation|epithelial cell morphogenesis|transmembrane signaling receptor activity|structural molecule activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|cell-cell junction|bicellular tight junction|cell adhesion|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|establishment of endothelial blood-brain barrier|integral component of membrane|apicolateral plasma membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|regulation of cell morphogenesis|positive regulation of cell migration|negative regulation of cell migration|actin cytoskeleton reorganization|protein-containing complex|cell junction maintenance|maintenance of blood-brain barrier|identical protein binding|apical junction complex|response to ethanol|negative regulation of wound healing|tight junction|bicellular tight junction assembly|positive regulation of wound healing|regulation of membrane permeability|regulation of transepithelial transport|positive regulation of cell junction assembly|positive regulation of bicellular tight junction assembly|positive regulation of metallopeptidase activity "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN4 11.64230208 21.31407534 1.970528833 0.092451997 -3.435151704 0.024373074 0.691114326 0.636862964 0.061415532 1364 claudin 4 "GO:0004888,GO:0005198,GO:0005254,GO:0005515,GO:0005886,GO:0005887,GO:0005911,GO:0005923,GO:0007155,GO:0007565,GO:0007623,GO:0009925,GO:0016324,GO:0016327,GO:0016328,GO:0016338,GO:0022604,GO:0030335,GO:0032570,GO:0034707,GO:0042802,GO:0061436,GO:0070160,GO:0070293,GO:0070830,GO:0090303,GO:1902476,GO:1905050" transmembrane signaling receptor activity|structural molecule activity|chloride channel activity|protein binding|plasma membrane|integral component of plasma membrane|cell-cell junction|bicellular tight junction|cell adhesion|female pregnancy|circadian rhythm|basal plasma membrane|apical plasma membrane|apicolateral plasma membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|regulation of cell morphogenesis|positive regulation of cell migration|response to progesterone|chloride channel complex|identical protein binding|establishment of skin barrier|tight junction|renal absorption|bicellular tight junction assembly|positive regulation of wound healing|chloride transmembrane transport|positive regulation of metallopeptidase activity "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN7 6.522984915 8.119647747 4.926322083 0.606716232 -0.720906186 0.726457076 1 0.257502513 0.16296075 1366 claudin 7 "GO:0005198,GO:0005515,GO:0005886,GO:0005923,GO:0007155,GO:0007162,GO:0008284,GO:0016021,GO:0016323,GO:0016327,GO:0016328,GO:0016338,GO:0019904,GO:0031333,GO:0042802,GO:0043066,GO:0045471,GO:0050839,GO:0070830,GO:2000147" structural molecule activity|protein binding|plasma membrane|bicellular tight junction|cell adhesion|negative regulation of cell adhesion|positive regulation of cell population proliferation|integral component of membrane|basolateral plasma membrane|apicolateral plasma membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|protein domain specific binding|negative regulation of protein-containing complex assembly|identical protein binding|negative regulation of apoptotic process|response to ethanol|cell adhesion molecule binding|bicellular tight junction assembly|positive regulation of cell motility "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDND1 1981.632735 1870.56385 2092.701621 1.118754445 0.161893414 0.616228077 1 40.00737333 46.68643822 56650 claudin domain containing 1 "GO:0005515,GO:0009986,GO:0016021" protein binding|cell surface|integral component of membrane CLDND2 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.248461575 0.11181453 125875 claudin domain containing 2 "GO:0005515,GO:0005886,GO:0016021" protein binding|plasma membrane|integral component of membrane CLEC11A 921.5738305 1000.746585 842.4010761 0.841772621 -0.248497508 0.48773364 1 36.86129753 32.36542725 6320 C-type lectin domain containing 11A "GO:0001503,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0007165,GO:0008083,GO:0008284,GO:0030246" ossification|protein binding|extracellular region|extracellular space|cytoplasm|signal transduction|growth factor activity|positive regulation of cell population proliferation|carbohydrate binding CLEC16A 603.4281879 569.3902983 637.4660775 1.119559078 0.16293066 0.678848463 1 2.18698695 2.553930867 23274 C-type lectin domain containing 16A "GO:0003674,GO:0005770,GO:0005794,GO:0005829,GO:0006914,GO:0008333,GO:0009267,GO:0016021,GO:0016197,GO:0031982,GO:0036020,GO:1901096,GO:1901097,GO:1904263,GO:1904766" molecular_function|late endosome|Golgi apparatus|cytosol|autophagy|endosome to lysosome transport|cellular response to starvation|integral component of membrane|endosomal transport|vesicle|endolysosome membrane|regulation of autophagosome maturation|negative regulation of autophagosome maturation|positive regulation of TORC1 signaling|negative regulation of macroautophagy by TORC1 signaling CLEC18A 10.00110192 10.14955968 9.852644165 0.970745971 -0.042834281 1 1 0.098986981 0.100230433 348174 C-type lectin domain family 18 member A "GO:0005515,GO:0005615,GO:0005768,GO:0005783,GO:0005794,GO:0030247" protein binding|extracellular space|endosome|endoplasmic reticulum|Golgi apparatus|polysaccharide binding CLEC2B 362.1789449 309.5615704 414.7963194 1.339947717 0.422176709 0.344911469 1 10.22713729 14.29413465 9976 C-type lectin domain family 2 member B "GO:0005515,GO:0005886,GO:0005887,GO:0009897,GO:0030246,GO:0042802,GO:0050776" protein binding|plasma membrane|integral component of plasma membrane|external side of plasma membrane|carbohydrate binding|identical protein binding|regulation of immune response hsa05167 Kaposi sarcoma-associated herpesvirus infection CLEC2D 137.1487084 148.1835714 126.1138453 0.85106496 -0.23265884 0.710545135 1 1.400443204 1.243208986 29121 C-type lectin domain family 2 member D "GO:0004888,GO:0005783,GO:0005886,GO:0005887,GO:0007166,GO:0009897,GO:0009986,GO:0016020,GO:0030246,GO:0046703,GO:0050776" transmembrane signaling receptor activity|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|external side of plasma membrane|cell surface|membrane|carbohydrate binding|natural killer cell lectin-like receptor binding|regulation of immune response CLEC3B 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.085187666 7123 C-type lectin domain family 3 member B "GO:0001503,GO:0001652,GO:0002576,GO:0005509,GO:0005576,GO:0005615,GO:0005737,GO:0008201,GO:0010756,GO:0030246,GO:0030282,GO:0031089,GO:0036143,GO:0062023,GO:0070062,GO:0071310,GO:0071560" ossification|granular component|platelet degranulation|calcium ion binding|extracellular region|extracellular space|cytoplasm|heparin binding|positive regulation of plasminogen activation|carbohydrate binding|bone mineralization|platelet dense granule lumen|kringle domain binding|collagen-containing extracellular matrix|extracellular exosome|cellular response to organic substance|cellular response to transforming growth factor beta stimulus CLEC4F 5.433800067 1.014955968 9.852644165 9.707459705 3.279093814 0.119754137 1 0.015004069 0.151925463 165530 C-type lectin domain family 4 member F "GO:0006897,GO:0016021,GO:0030246" endocytosis|integral component of membrane|carbohydrate binding CLGN 438.8971951 468.9096574 408.8847329 0.871990428 -0.197615796 0.642819323 1 8.454474878 7.689786557 1047 calmegin "GO:0005509,GO:0005635,GO:0005783,GO:0005789,GO:0006457,GO:0007338,GO:0007339,GO:0016021,GO:0030968,GO:0044183,GO:0051082,GO:0065003" calcium ion binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|single fertilization|binding of sperm to zona pellucida|integral component of membrane|endoplasmic reticulum unfolded protein response|protein folding chaperone|unfolded protein binding|protein-containing complex assembly CLHC1 83.09822063 90.33108119 75.86536007 0.839858873 -0.251781172 0.738085462 1 0.825058718 0.722781624 130162 clathrin heavy chain linker domain containing 1 GO:0005515 protein binding CLIC1 6525.647745 6213.560438 6837.735051 1.100453616 0.138098337 0.6720401 1 180.8591472 207.6003828 1192 chloride intracellular channel 1 "GO:0005244,GO:0005254,GO:0005515,GO:0005615,GO:0005634,GO:0005635,GO:0005737,GO:0005739,GO:0005886,GO:0005903,GO:0006749,GO:0006821,GO:0007165,GO:0016020,GO:0031965,GO:0031982,GO:0034707,GO:0034765,GO:0045296,GO:0045669,GO:0048471,GO:0051726,GO:0051881,GO:0070062,GO:0070527,GO:0072562,GO:1902476" voltage-gated ion channel activity|chloride channel activity|protein binding|extracellular space|nucleus|nuclear envelope|cytoplasm|mitochondrion|plasma membrane|brush border|glutathione metabolic process|chloride transport|signal transduction|membrane|nuclear membrane|vesicle|chloride channel complex|regulation of ion transmembrane transport|cadherin binding|positive regulation of osteoblast differentiation|perinuclear region of cytoplasm|regulation of cell cycle|regulation of mitochondrial membrane potential|extracellular exosome|platelet aggregation|blood microparticle|chloride transmembrane transport CLIC2 13.50891049 14.20938356 12.80843742 0.901406973 -0.149749485 0.969790133 1 0.274363381 0.257966309 1193 chloride intracellular channel 2 "GO:0004364,GO:0004602,GO:0005244,GO:0005254,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006749,GO:0007165,GO:0010880,GO:0010881,GO:0034707,GO:0051099,GO:0060315,GO:0098869,GO:1902476" glutathione transferase activity|glutathione peroxidase activity|voltage-gated ion channel activity|chloride channel activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|glutathione metabolic process|signal transduction|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|chloride channel complex|positive regulation of binding|negative regulation of ryanodine-sensitive calcium-release channel activity|cellular oxidant detoxification|chloride transmembrane transport CLIC4 9348.783882 8292.190262 10405.3775 1.25484066 0.327504182 0.327901075 1 98.74681017 129.2491179 25932 chloride intracellular channel 4 "GO:0001525,GO:0001886,GO:0005244,GO:0005254,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0005902,GO:0005911,GO:0006821,GO:0007035,GO:0009566,GO:0009986,GO:0015629,GO:0015630,GO:0016363,GO:0030154,GO:0030216,GO:0030336,GO:0030496,GO:0030659,GO:0034707,GO:0034765,GO:0035088,GO:0035264,GO:0045177,GO:0048471,GO:0048754,GO:0051493,GO:0061299,GO:0070062,GO:0071277,GO:1902476" angiogenesis|endothelial cell morphogenesis|voltage-gated ion channel activity|chloride channel activity|protein binding|nucleus|cytoplasm|mitochondrion|centrosome|cytosol|plasma membrane|microvillus|cell-cell junction|chloride transport|vacuolar acidification|fertilization|cell surface|actin cytoskeleton|microtubule cytoskeleton|nuclear matrix|cell differentiation|keratinocyte differentiation|negative regulation of cell migration|midbody|cytoplasmic vesicle membrane|chloride channel complex|regulation of ion transmembrane transport|establishment or maintenance of apical/basal cell polarity|multicellular organism growth|apical part of cell|perinuclear region of cytoplasm|branching morphogenesis of an epithelial tube|regulation of cytoskeleton organization|retina vasculature morphogenesis in camera-type eye|extracellular exosome|cellular response to calcium ion|chloride transmembrane transport CLIC5 5.463491619 3.044867905 7.882115332 2.588655921 1.372203218 0.484534422 1 0.019332057 0.052199738 53405 chloride intracellular channel 5 "GO:0005244,GO:0005254,GO:0005515,GO:0005794,GO:0005815,GO:0005938,GO:0006749,GO:0006821,GO:0007565,GO:0007601,GO:0007605,GO:0015629,GO:0016324,GO:0034707,GO:0034765,GO:0050896,GO:0070062,GO:1902476" voltage-gated ion channel activity|chloride channel activity|protein binding|Golgi apparatus|microtubule organizing center|cell cortex|glutathione metabolic process|chloride transport|female pregnancy|visual perception|sensory perception of sound|actin cytoskeleton|apical plasma membrane|chloride channel complex|regulation of ion transmembrane transport|response to stimulus|extracellular exosome|chloride transmembrane transport CLINT1 3192.5284 3453.89516 2931.161639 0.848653912 -0.236751764 0.456789546 1 42.9270197 37.99944774 9685 clathrin interactor 1 "GO:0005515,GO:0005543,GO:0005654,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0006897,GO:0016020,GO:0030125,GO:0030276,GO:0043231,GO:0045296,GO:0048268,GO:0048471" protein binding|phospholipid binding|nucleoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|endocytosis|membrane|clathrin vesicle coat|clathrin binding|intracellular membrane-bounded organelle|cadherin binding|clathrin coat assembly|perinuclear region of cytoplasm CLIP1 2215.518227 1997.433346 2433.603109 1.218365115 0.28494654 0.373847833 1 11.44636258 14.54657947 6249 CAP-Gly domain containing linker protein 1 "GO:0000278,GO:0000776,GO:0001578,GO:0001726,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0005882,GO:0008017,GO:0008270,GO:0015630,GO:0015631,GO:0030659,GO:0031116,GO:0031122,GO:0035371,GO:0044354,GO:0051010" mitotic cell cycle|kinetochore|microtubule bundle formation|ruffle|protein binding|nucleus|cytoplasm|centrosome|cytosol|microtubule|intermediate filament|microtubule binding|zinc ion binding|microtubule cytoskeleton|tubulin binding|cytoplasmic vesicle membrane|positive regulation of microtubule polymerization|cytoplasmic microtubule organization|microtubule plus-end|macropinosome|microtubule plus-end binding hsa04150 mTOR signaling pathway CLIP2 3940.676142 3409.237098 4472.115187 1.311764204 0.391508411 0.219477438 1 30.70706597 42.0155475 7461 CAP-Gly domain containing linker protein 2 "GO:0005634,GO:0005737,GO:0005875,GO:0008017,GO:0031122,GO:0035371,GO:0051010" nucleus|cytoplasm|microtubule associated complex|microtubule binding|cytoplasmic microtubule organization|microtubule plus-end|microtubule plus-end binding CLIP3 15.15011065 25.37389921 4.926322083 0.194149194 -2.364762376 0.064048195 1 0.359971563 0.072898689 25999 CAP-Gly domain containing linker protein 3 "GO:0001934,GO:0005515,GO:0005634,GO:0005737,GO:0005795,GO:0005802,GO:0005829,GO:0005886,GO:0008017,GO:0010803,GO:0010828,GO:0018230,GO:0031115,GO:0031122,GO:0031901,GO:0032588,GO:0035371,GO:0035594,GO:0043065,GO:0044091,GO:0045121,GO:0045444,GO:0045807,GO:0051010,GO:0055038,GO:0072321,GO:1903078" positive regulation of protein phosphorylation|protein binding|nucleus|cytoplasm|Golgi stack|trans-Golgi network|cytosol|plasma membrane|microtubule binding|regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of glucose transmembrane transport|peptidyl-L-cysteine S-palmitoylation|negative regulation of microtubule polymerization|cytoplasmic microtubule organization|early endosome membrane|trans-Golgi network membrane|microtubule plus-end|ganglioside binding|positive regulation of apoptotic process|membrane biogenesis|membrane raft|fat cell differentiation|positive regulation of endocytosis|microtubule plus-end binding|recycling endosome membrane|chaperone-mediated protein transport|positive regulation of protein localization to plasma membrane CLIP4 676.0799333 619.1231407 733.0367259 1.183991807 0.243659097 0.523164963 1 4.655739115 5.749806948 79745 CAP-Gly domain containing linker protein family member 4 "GO:0005515,GO:0005634,GO:0005737,GO:0031122,GO:0035371,GO:0043231,GO:0051010" protein binding|nucleus|cytoplasm|cytoplasmic microtubule organization|microtubule plus-end|intracellular membrane-bounded organelle|microtubule plus-end binding CLK1 1004.689618 1058.599075 950.780162 0.898149436 -0.154972592 0.661252586 1 23.22976977 21.7625327 1195 CDC like kinase 1 "GO:0004674,GO:0004712,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0018105,GO:0018107,GO:0018108,GO:0043484,GO:0046777" protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|regulation of RNA splicing|protein autophosphorylation hsa05134 Legionellosis CLK2 674.7680618 596.7941094 752.7420142 1.26130939 0.334922202 0.379506182 1 14.03227311 18.46144061 1196 CDC like kinase 2 "GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006468,GO:0010212,GO:0016604,GO:0016607,GO:0018108,GO:0042802,GO:0043484,GO:0045721,GO:0046777" protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|protein phosphorylation|response to ionizing radiation|nuclear body|nuclear speck|peptidyl-tyrosine phosphorylation|identical protein binding|regulation of RNA splicing|negative regulation of gluconeogenesis|protein autophosphorylation CLK3 1506.145661 1594.495826 1417.795495 0.889181064 -0.16945087 0.60985778 1 42.3025608 39.23492199 1198 CDC like kinase 3 "GO:0001669,GO:0003723,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006468,GO:0016020,GO:0016607,GO:0018108,GO:0042802,GO:0043484,GO:0045111,GO:0046777" acrosomal vesicle|RNA binding|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|protein phosphorylation|membrane|nuclear speck|peptidyl-tyrosine phosphorylation|identical protein binding|regulation of RNA splicing|intermediate filament cytoskeleton|protein autophosphorylation CLK4 313.7498091 332.9055576 294.5940605 0.884917821 -0.176384612 0.709510431 1 6.733423352 6.215195467 57396 CDC like kinase 4 "GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0018108,GO:0043484,GO:0046777" protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|peptidyl-tyrosine phosphorylation|regulation of RNA splicing|protein autophosphorylation hsa05134 Legionellosis CLMN 824.0559099 530.8219715 1117.289848 2.104829695 1.073703507 0.003560292 0.215429478 1.959637016 4.302377625 79789 calmin "GO:0005640,GO:0005737,GO:0007097,GO:0008285,GO:0016021,GO:0031175,GO:0034993,GO:0051015" nuclear outer membrane|cytoplasm|nuclear migration|negative regulation of cell population proliferation|integral component of membrane|neuron projection development|meiotic nuclear membrane microtubule tethering complex|actin filament binding CLMP 555.0072169 492.2536447 617.7607892 1.254964378 0.327646414 0.411392189 1 4.954473477 6.485520498 79827 CXADR like membrane protein "GO:0005515,GO:0005881,GO:0005886,GO:0005923,GO:0009986,GO:0016021,GO:0048565" protein binding|cytoplasmic microtubule|plasma membrane|bicellular tight junction|cell surface|integral component of membrane|digestive tract development CLN3 629.3810724 659.7213794 599.0407653 0.908020846 -0.139202676 0.721463862 1 8.649381442 8.192129312 1201 "CLN3 lysosomal/endosomal transmembrane protein, battenin" "GO:0000139,GO:0001508,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005773,GO:0005776,GO:0005783,GO:0005794,GO:0005795,GO:0005802,GO:0005829,GO:0005886,GO:0005901,GO:0006898,GO:0007040,GO:0007042,GO:0007611,GO:0008021,GO:0008306,GO:0009992,GO:0010762,GO:0015809,GO:0016021,GO:0016485,GO:0030176,GO:0031901,GO:0031902,GO:0032228,GO:0035235,GO:0035752,GO:0036359,GO:0042133,GO:0042987,GO:0042998,GO:0043005,GO:0043066,GO:0043086,GO:0043524,GO:0044754,GO:0044857,GO:0045121,GO:0045861,GO:0046474,GO:0046836,GO:0047496,GO:0048172,GO:0048549,GO:0050885,GO:0051453,GO:0051480,GO:0051493,GO:0051861,GO:0051966,GO:0055037,GO:0061024,GO:0061909,GO:0070613,GO:0090160,GO:0090384,GO:0090385,GO:0097352,GO:0106049,GO:0120146,GO:1900079,GO:1901096,GO:1903076,GO:1905146,GO:1905162,GO:1905244,GO:2001288" "Golgi membrane|action potential|protein binding|nucleus|cytoplasm|lysosome|lysosomal membrane|early endosome|late endosome|vacuole|autophagosome|endoplasmic reticulum|Golgi apparatus|Golgi stack|trans-Golgi network|cytosol|plasma membrane|caveola|receptor-mediated endocytosis|lysosome organization|lysosomal lumen acidification|learning or memory|synaptic vesicle|associative learning|cellular water homeostasis|regulation of fibroblast migration|arginine transport|integral component of membrane|protein processing|integral component of endoplasmic reticulum membrane|early endosome membrane|late endosome membrane|regulation of synaptic transmission, GABAergic|ionotropic glutamate receptor signaling pathway|lysosomal lumen pH elevation|renal potassium excretion|neurotransmitter metabolic process|amyloid precursor protein catabolic process|positive regulation of Golgi to plasma membrane protein transport|neuron projection|negative regulation of apoptotic process|negative regulation of catalytic activity|negative regulation of neuron apoptotic process|autolysosome|plasma membrane raft organization|membrane raft|negative regulation of proteolysis|glycerophospholipid biosynthetic process|glycolipid transport|vesicle transport along microtubule|regulation of short-term neuronal synaptic plasticity|positive regulation of pinocytosis|neuromuscular process controlling balance|regulation of intracellular pH|regulation of cytosolic calcium ion concentration|regulation of cytoskeleton organization|glycolipid binding|regulation of synaptic transmission, glutamatergic|recycling endosome|membrane organization|autophagosome-lysosome fusion|regulation of protein processing|Golgi to lysosome transport|phagosome-lysosome docking|phagosome-lysosome fusion|autophagosome maturation|regulation of cellular response to osmotic stress|sulfatide binding|regulation of arginine biosynthetic process|regulation of autophagosome maturation|regulation of protein localization to plasma membrane|lysosomal protein catabolic process|regulation of phagosome maturation|regulation of modification of synaptic structure|positive regulation of caveolin-mediated endocytosis" hsa04142 Lysosome CLN5 205.1386341 249.6791682 160.5980999 0.643217859 -0.636620632 0.234149777 1 2.392237808 1.605012331 1203 CLN5 intracellular trafficking protein "GO:0005515,GO:0005537,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005829,GO:0006465,GO:0007040,GO:0007042,GO:0007420,GO:0016021,GO:0016798,GO:0022008,GO:0030163,GO:0042147,GO:0042551,GO:0048471,GO:0070062,GO:0070085,GO:1904426" "protein binding|mannose binding|lysosome|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|cytosol|signal peptide processing|lysosome organization|lysosomal lumen acidification|brain development|integral component of membrane|hydrolase activity, acting on glycosyl bonds|neurogenesis|protein catabolic process|retrograde transport, endosome to Golgi|neuron maturation|perinuclear region of cytoplasm|extracellular exosome|glycosylation|positive regulation of GTP binding" hsa04142 Lysosome CLN6 718.8174476 644.4970399 793.1378553 1.230630719 0.29939791 0.425962608 1 14.65058412 18.80609483 54982 CLN6 transmembrane ER protein "GO:0001573,GO:0005515,GO:0005730,GO:0005769,GO:0005783,GO:0005788,GO:0005789,GO:0007040,GO:0007042,GO:0007601,GO:0008203,GO:0016020,GO:0016021,GO:0030163,GO:0030203,GO:0031987,GO:0035727,GO:0042803,GO:0043231,GO:0044265,GO:0045121,GO:0045862,GO:0120146" ganglioside metabolic process|protein binding|nucleolus|early endosome|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|lysosome organization|lysosomal lumen acidification|visual perception|cholesterol metabolic process|membrane|integral component of membrane|protein catabolic process|glycosaminoglycan metabolic process|locomotion involved in locomotory behavior|lysophosphatidic acid binding|protein homodimerization activity|intracellular membrane-bounded organelle|cellular macromolecule catabolic process|membrane raft|positive regulation of proteolysis|sulfatide binding CLN8 158.5221668 194.8715459 122.1727877 0.626940106 -0.673600472 0.247471691 1 2.774685503 1.814494883 2055 CLN8 transmembrane ER and ERGIC protein "GO:0001306,GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005793,GO:0006644,GO:0006672,GO:0006869,GO:0007006,GO:0007040,GO:0007399,GO:0007601,GO:0007628,GO:0008203,GO:0008306,GO:0008361,GO:0008610,GO:0016021,GO:0021523,GO:0030163,GO:0033116,GO:0035176,GO:0043066,GO:0044257,GO:0045494,GO:0045861,GO:0046513,GO:0050881,GO:0050884,GO:0050885,GO:0051935,GO:0055088,GO:0060041,GO:0060052,GO:0097001,GO:0098793" age-dependent response to oxidative stress|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|phospholipid metabolic process|ceramide metabolic process|lipid transport|mitochondrial membrane organization|lysosome organization|nervous system development|visual perception|adult walking behavior|cholesterol metabolic process|associative learning|regulation of cell size|lipid biosynthetic process|integral component of membrane|somatic motor neuron differentiation|protein catabolic process|endoplasmic reticulum-Golgi intermediate compartment membrane|social behavior|negative regulation of apoptotic process|cellular protein catabolic process|photoreceptor cell maintenance|negative regulation of proteolysis|ceramide biosynthetic process|musculoskeletal movement|neuromuscular process controlling posture|neuromuscular process controlling balance|glutamate reuptake|lipid homeostasis|retina development in camera-type eye|neurofilament cytoskeleton organization|ceramide binding|presynapse CLNS1A 2225.523289 2142.572049 2308.474528 1.077431459 0.107596094 0.737734515 1 34.66891877 38.962416 1207 chloride nucleotide-sensitive channel 1A "GO:0000387,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0006821,GO:0006884,GO:0034709,GO:0034715" spliceosomal snRNP assembly|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|cytoskeleton|plasma membrane|chloride transport|cell volume homeostasis|methylosome|pICln-Sm protein complex hsa03013 RNA transport CLOCK 964.7567181 1056.569163 872.9442731 0.826206465 -0.275425746 0.437797898 1 4.527965879 3.902183284 9575 clock circadian regulator "GO:0000077,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005694,GO:0005829,GO:0006355,GO:0006357,GO:0006473,GO:0007165,GO:0007283,GO:0007623,GO:0009648,GO:0016573,GO:0031490,GO:0032922,GO:0033391,GO:0042634,GO:0042752,GO:0043161,GO:0043231,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0050729,GO:0050796,GO:0051092,GO:0051775,GO:0070888,GO:0071479,GO:1990513,GO:1990837,GO:2000074,GO:2000323" "DNA damage checkpoint|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|chromosome|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|protein acetylation|signal transduction|spermatogenesis|circadian rhythm|photoperiodism|histone acetylation|chromatin DNA binding|circadian regulation of gene expression|chromatoid body|regulation of hair cycle|regulation of circadian rhythm|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|positive regulation of inflammatory response|regulation of insulin secretion|positive regulation of NF-kappaB transcription factor activity|response to redox state|E-box binding|cellular response to ionizing radiation|CLOCK-BMAL transcription complex|sequence-specific double-stranded DNA binding|regulation of type B pancreatic cell development|negative regulation of glucocorticoid receptor signaling pathway" "hsa04710,hsa04728" Circadian rhythm|Dopaminergic synapse bHLH CLP1 385.250265 404.9674314 365.5330985 0.902623446 -0.147803841 0.740007703 1 12.5367798 11.80343841 10978 cleavage factor polyribonucleotide kinase subunit 1 "GO:0000214,GO:0000398,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005849,GO:0006369,GO:0006378,GO:0006388,GO:0006396,GO:0016310,GO:0021695,GO:0030423,GO:0031124,GO:0035087,GO:0046404,GO:0051731,GO:0051733,GO:0051736" "tRNA-intron endonuclease complex|mRNA splicing, via spliceosome|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|tRNA splicing, via endonucleolytic cleavage and ligation|RNA processing|phosphorylation|cerebellar cortex development|targeting of mRNA for destruction involved in RNA interference|mRNA 3'-end processing|siRNA loading onto RISC involved in RNA interference|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|polynucleotide 5'-hydroxyl-kinase activity|polydeoxyribonucleotide kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity" hsa03015 mRNA surveillance pathway CLPB 1081.737197 1206.782646 956.6917485 0.792762269 -0.335039796 0.335499005 1 5.941987533 4.91349635 81570 caseinolytic mitochondrial matrix peptidase chaperone subunit B "GO:0003674,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005758,GO:0016887,GO:0034605,GO:0039529,GO:0140374" molecular_function|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial intermembrane space|ATPase activity|cellular response to heat|RIG-I signaling pathway|antiviral innate immune response hsa04213 Longevity regulating pathway - multiple species CLPP 961.4176562 996.6867609 926.1485516 0.929227304 -0.105896549 0.767428916 1 20.94550554 20.30152858 8192 caseinolytic mitochondrial matrix peptidase proteolytic subunit "GO:0004175,GO:0004176,GO:0004252,GO:0005515,GO:0005739,GO:0005759,GO:0006515,GO:0008233,GO:0009368,GO:0033619,GO:0042802,GO:0051117,GO:0051603" endopeptidase activity|ATP-dependent peptidase activity|serine-type endopeptidase activity|protein binding|mitochondrion|mitochondrial matrix|protein quality control for misfolded or incompletely synthesized proteins|peptidase activity|endopeptidase Clp complex|membrane protein proteolysis|identical protein binding|ATPase binding|proteolysis involved in cellular protein catabolic process CLPSL2 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.407159915 0.206137282 389383 colipase like 2 "GO:0005515,GO:0005576,GO:0007586,GO:0008047,GO:0016042,GO:0032094,GO:0050790" protein binding|extracellular region|digestion|enzyme activator activity|lipid catabolic process|response to food|regulation of catalytic activity CLPTM1 2436.998593 2488.672034 2385.325152 0.958473081 -0.061190181 0.849062114 1 47.0307683 47.01949098 1209 CLPTM1 regulator of GABA type A receptor forward trafficking "GO:0005515,GO:0005887,GO:0007275,GO:0009897,GO:0012505,GO:0016020,GO:0030154,GO:0033081" protein binding|integral component of plasma membrane|multicellular organism development|external side of plasma membrane|endomembrane system|membrane|cell differentiation|regulation of T cell differentiation in thymus CLPTM1L 3391.815077 3337.175224 3446.454929 1.032746169 0.046485709 0.884626475 1 73.13550508 78.78395658 81037 CLPTM1 like "GO:0005515,GO:0006915,GO:0012505,GO:0016020,GO:0016021" protein binding|apoptotic process|endomembrane system|membrane|integral component of membrane CLPX 548.0779528 523.7172797 572.438626 1.093029862 0.128332817 0.751188282 1 5.611261403 6.397472946 10845 caseinolytic mitochondrial matrix peptidase chaperone subunit X "GO:0004176,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006457,GO:0006508,GO:0008270,GO:0009368,GO:0009841,GO:0010952,GO:0016504,GO:0016887,GO:0030163,GO:0042645,GO:0046034,GO:0046983,GO:0051082,GO:0051603" ATP-dependent peptidase activity|protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|protein folding|proteolysis|zinc ion binding|endopeptidase Clp complex|mitochondrial endopeptidase Clp complex|positive regulation of peptidase activity|peptidase activator activity|ATPase activity|protein catabolic process|mitochondrial nucleoid|ATP metabolic process|protein dimerization activity|unfolded protein binding|proteolysis involved in cellular protein catabolic process CLSPN 800.7819461 724.6785614 876.8853307 1.210033493 0.275046981 0.454628651 1 3.95202031 4.98806942 63967 claspin "GO:0000076,GO:0000077,GO:0000217,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0006260,GO:0006281,GO:0007095,GO:0010997,GO:0016579,GO:0018105,GO:0032147,GO:0033314" DNA replication checkpoint|DNA damage checkpoint|DNA secondary structure binding|protein binding|nucleus|nucleoplasm|Golgi apparatus|DNA replication|DNA repair|mitotic G2 DNA damage checkpoint|anaphase-promoting complex binding|protein deubiquitination|peptidyl-serine phosphorylation|activation of protein kinase activity|mitotic DNA replication checkpoint CLSTN1 12265.60205 13037.10941 11494.09468 0.881644414 -0.181731192 0.596144449 1 124.0901334 114.1160265 22883 calsyntenin 1 "GO:0000139,GO:0001540,GO:0001558,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005789,GO:0007155,GO:0007156,GO:0009986,GO:0019894,GO:0042988,GO:0045211,GO:0050806,GO:0051965,GO:0090128,GO:0098845,GO:0098969,GO:0098978,GO:0098982,GO:0099003,GO:0099061,GO:0099065" Golgi membrane|amyloid-beta binding|regulation of cell growth|calcium ion binding|protein binding|extracellular region|nucleus|endoplasmic reticulum membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell surface|kinesin binding|X11-like protein binding|postsynaptic membrane|positive regulation of synaptic transmission|positive regulation of synapse assembly|regulation of synapse maturation|postsynaptic endosome|neurotransmitter receptor transport to postsynaptic membrane|glutamatergic synapse|GABA-ergic synapse|vesicle-mediated transport in synapse|integral component of postsynaptic density membrane|integral component of spine apparatus membrane CLSTN3 2936.458375 3157.528018 2715.388732 0.859972965 -0.217636788 0.49419355 1 28.14460665 25.2461938 9746 calsyntenin 3 "GO:0000139,GO:0001558,GO:0005509,GO:0005515,GO:0005789,GO:0007156,GO:0007416,GO:0009986,GO:0030425,GO:0032991,GO:0035249,GO:0045211,GO:0050806,GO:0051932,GO:0051965,GO:0098978,GO:0098982,GO:0099061,GO:1902474,GO:1905606" "Golgi membrane|regulation of cell growth|calcium ion binding|protein binding|endoplasmic reticulum membrane|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|cell surface|dendrite|protein-containing complex|synaptic transmission, glutamatergic|postsynaptic membrane|positive regulation of synaptic transmission|synaptic transmission, GABAergic|positive regulation of synapse assembly|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic density membrane|positive regulation of protein localization to synapse|regulation of presynapse assembly" CLTA 4132.248712 4348.071369 3916.426056 0.900727179 -0.150837901 0.636529045 1 231.3177266 217.3292156 1211 clathrin light chain A "GO:0003674,GO:0005198,GO:0005515,GO:0005819,GO:0005829,GO:0005886,GO:0006886,GO:0007049,GO:0016020,GO:0019886,GO:0030118,GO:0030125,GO:0030130,GO:0030132,GO:0030672,GO:0031410,GO:0032050,GO:0032588,GO:0032802,GO:0034383,GO:0036020,GO:0042277,GO:0044877,GO:0045334,GO:0048268,GO:0051020,GO:0051301,GO:0061024,GO:0071439,GO:0072583,GO:0098835,GO:0099631" molecular_function|structural molecule activity|protein binding|spindle|cytosol|plasma membrane|intracellular protein transport|cell cycle|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|clathrin coat|clathrin vesicle coat|clathrin coat of trans-Golgi network vesicle|clathrin coat of coated pit|synaptic vesicle membrane|cytoplasmic vesicle|clathrin heavy chain binding|trans-Golgi network membrane|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|endolysosome membrane|peptide binding|protein-containing complex binding|clathrin-coated endocytic vesicle|clathrin coat assembly|GTPase binding|cell division|membrane organization|clathrin complex|clathrin-dependent endocytosis|presynaptic endocytic zone membrane|postsynaptic endocytic zone cytoplasmic component "hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100" Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTB 978.9148833 980.4474654 977.3823012 0.996873709 -0.00451735 0.993098388 1 19.84660484 20.63679712 1212 clathrin light chain B "GO:0005198,GO:0005515,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0030118,GO:0030125,GO:0030130,GO:0030132,GO:0030672,GO:0032050,GO:0042277,GO:0043231,GO:0045334,GO:0048268,GO:0060170,GO:0061024,GO:0072583,GO:0098835,GO:0099631" structural molecule activity|protein binding|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|clathrin coat|clathrin vesicle coat|clathrin coat of trans-Golgi network vesicle|clathrin coat of coated pit|synaptic vesicle membrane|clathrin heavy chain binding|peptide binding|intracellular membrane-bounded organelle|clathrin-coated endocytic vesicle|clathrin coat assembly|ciliary membrane|membrane organization|clathrin-dependent endocytosis|presynaptic endocytic zone membrane|postsynaptic endocytic zone cytoplasmic component "hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100" Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTC 14886.12136 15981.49668 13790.74604 0.862919557 -0.212702019 0.543543062 1 96.71483181 87.0521141 1213 clathrin heavy chain "GO:0000278,GO:0001649,GO:0003723,GO:0003725,GO:0005198,GO:0005515,GO:0005764,GO:0005768,GO:0005819,GO:0005829,GO:0005886,GO:0005925,GO:0006886,GO:0006898,GO:0006914,GO:0016020,GO:0019886,GO:0019901,GO:0030118,GO:0030130,GO:0030132,GO:0030136,GO:0030669,GO:0031623,GO:0032051,GO:0032588,GO:0032802,GO:0032991,GO:0033572,GO:0034383,GO:0036020,GO:0042147,GO:0042470,GO:0045334,GO:0048268,GO:0050750,GO:0051301,GO:0060071,GO:0060236,GO:0061024,GO:0070062,GO:0071439,GO:0072583,GO:0072686,GO:0097718,GO:0150093,GO:1900126,GO:1903077,GO:1903561,GO:1990381,GO:1990498" "mitotic cell cycle|osteoblast differentiation|RNA binding|double-stranded RNA binding|structural molecule activity|protein binding|lysosome|endosome|spindle|cytosol|plasma membrane|focal adhesion|intracellular protein transport|receptor-mediated endocytosis|autophagy|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|clathrin coat|clathrin coat of trans-Golgi network vesicle|clathrin coat of coated pit|clathrin-coated vesicle|clathrin-coated endocytic vesicle membrane|receptor internalization|clathrin light chain binding|trans-Golgi network membrane|low-density lipoprotein particle receptor catabolic process|protein-containing complex|transferrin transport|low-density lipoprotein particle clearance|endolysosome membrane|retrograde transport, endosome to Golgi|melanosome|clathrin-coated endocytic vesicle|clathrin coat assembly|low-density lipoprotein particle receptor binding|cell division|Wnt signaling pathway, planar cell polarity pathway|regulation of mitotic spindle organization|membrane organization|extracellular exosome|clathrin complex|clathrin-dependent endocytosis|mitotic spindle|disordered domain specific binding|amyloid-beta clearance by transcytosis|negative regulation of hyaluronan biosynthetic process|negative regulation of protein localization to plasma membrane|extracellular vesicle|ubiquitin-specific protease binding|mitotic spindle microtubule" "hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100" Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTCL1 399.7944204 355.2345889 444.3542519 1.250875522 0.32293823 0.457840623 1 3.208163113 4.185877021 8218 clathrin heavy chain like 1 "GO:0000278,GO:0005198,GO:0005515,GO:0005769,GO:0005770,GO:0005802,GO:0005819,GO:0005829,GO:0005886,GO:0005905,GO:0006886,GO:0006898,GO:0009653,GO:0016020,GO:0030130,GO:0030135,GO:0030136,GO:0032051,GO:0042147,GO:0045334,GO:0046326,GO:0055037,GO:0061024,GO:0070062,GO:0071439,GO:0097443" "mitotic cell cycle|structural molecule activity|protein binding|early endosome|late endosome|trans-Golgi network|spindle|cytosol|plasma membrane|clathrin-coated pit|intracellular protein transport|receptor-mediated endocytosis|anatomical structure morphogenesis|membrane|clathrin coat of trans-Golgi network vesicle|coated vesicle|clathrin-coated vesicle|clathrin light chain binding|retrograde transport, endosome to Golgi|clathrin-coated endocytic vesicle|positive regulation of glucose import|recycling endosome|membrane organization|extracellular exosome|clathrin complex|sorting endosome" "hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100" Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTRN 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.094608477 0.159661545 57393 "collectrin, amino acid transport regulator" "GO:0005515,GO:0005737,GO:0005886,GO:0016021,GO:0022898,GO:0035543,GO:0035774,GO:0042803,GO:0045956,GO:0051957,GO:0070062,GO:1905737" protein binding|cytoplasm|plasma membrane|integral component of membrane|regulation of transmembrane transporter activity|positive regulation of SNARE complex assembly|positive regulation of insulin secretion involved in cellular response to glucose stimulus|protein homodimerization activity|positive regulation of calcium ion-dependent exocytosis|positive regulation of amino acid transport|extracellular exosome|positive regulation of L-proline import across plasma membrane CLU 356.6790807 202.9911937 510.3669678 2.514232064 1.330117817 0.003425294 0.209128079 3.739828247 9.807830411 1191 clusterin "GO:0000902,GO:0001540,GO:0001774,GO:0001836,GO:0002434,GO:0002576,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005743,GO:0005794,GO:0005829,GO:0005856,GO:0006629,GO:0006956,GO:0006958,GO:0009615,GO:0009986,GO:0010628,GO:0016020,GO:0016887,GO:0017038,GO:0019730,GO:0030449,GO:0031093,GO:0031333,GO:0031334,GO:0031625,GO:0032286,GO:0032436,GO:0032760,GO:0032991,GO:0034366,GO:0042127,GO:0042583,GO:0042981,GO:0043065,GO:0043231,GO:0043691,GO:0044877,GO:0045087,GO:0045202,GO:0045429,GO:0048156,GO:0048260,GO:0048471,GO:0050750,GO:0050821,GO:0051082,GO:0051087,GO:0051092,GO:0051131,GO:0051787,GO:0051788,GO:0060548,GO:0061077,GO:0061518,GO:0061740,GO:0061741,GO:0062023,GO:0070062,GO:0071944,GO:0072562,GO:0090201,GO:0097418,GO:0097440,GO:0099020,GO:1900221,GO:1901214,GO:1901216,GO:1902004,GO:1902230,GO:1902430,GO:1902847,GO:1902949,GO:1902998,GO:1903573,GO:1905892,GO:1905895,GO:1905907,GO:1905908,GO:2000060" "cell morphogenesis|amyloid-beta binding|microglial cell activation|release of cytochrome c from mitochondria|immune complex clearance|platelet degranulation|signaling receptor binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|mitochondrial inner membrane|Golgi apparatus|cytosol|cytoskeleton|lipid metabolic process|complement activation|complement activation, classical pathway|response to virus|cell surface|positive regulation of gene expression|membrane|ATPase activity|protein import|antimicrobial humoral response|regulation of complement activation|platelet alpha granule lumen|negative regulation of protein-containing complex assembly|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|central nervous system myelin maintenance|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of tumor necrosis factor production|protein-containing complex|spherical high-density lipoprotein particle|regulation of cell population proliferation|chromaffin granule|regulation of apoptotic process|positive regulation of apoptotic process|intracellular membrane-bounded organelle|reverse cholesterol transport|protein-containing complex binding|innate immune response|synapse|positive regulation of nitric oxide biosynthetic process|tau protein binding|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|low-density lipoprotein particle receptor binding|protein stabilization|unfolded protein binding|chaperone binding|positive regulation of NF-kappaB transcription factor activity|chaperone-mediated protein complex assembly|misfolded protein binding|response to misfolded protein|negative regulation of cell death|chaperone-mediated protein folding|microglial cell proliferation|protein targeting to lysosome involved in chaperone-mediated autophagy|chaperone-mediated protein transport involved in chaperone-mediated autophagy|collagen-containing extracellular matrix|extracellular exosome|cell periphery|blood microparticle|negative regulation of release of cytochrome c from mitochondria|neurofibrillary tangle|apical dendrite|perinuclear endoplasmic reticulum lumen|regulation of amyloid-beta clearance|regulation of neuron death|positive regulation of neuron death|positive regulation of amyloid-beta formation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of amyloid-beta formation|regulation of neuronal signal transduction|positive regulation of tau-protein kinase activity|positive regulation of neurofibrillary tangle assembly|negative regulation of response to endoplasmic reticulum stress|negative regulation of cellular response to thapsigargin|negative regulation of cellular response to tunicamycin|negative regulation of amyloid fibril formation|positive regulation of amyloid fibril formation|positive regulation of ubiquitin-dependent protein catabolic process" hsa04610 Complement and coagulation cascades CLUAP1 271.5521859 277.0829794 266.0213925 0.960078432 -0.058775825 0.91167692 1 3.3112967 3.316047475 23059 clusterin associated protein 1 "GO:0005515,GO:0005654,GO:0005813,GO:0005929,GO:0030992,GO:0035735,GO:0043231,GO:0060271,GO:0097542" protein binding|nucleoplasm|centrosome|cilium|intraciliary transport particle B|intraciliary transport involved in cilium assembly|intracellular membrane-bounded organelle|cilium assembly|ciliary tip CLUH 2453.441524 2770.829794 2136.053255 0.770907423 -0.375370476 0.239780395 1 21.09632504 16.96387115 23277 clustered mitochondria homolog "GO:0003729,GO:0005737,GO:0007005,GO:0048312" mRNA binding|cytoplasm|mitochondrion organization|intracellular distribution of mitochondria CLYBL 45.2276453 60.8973581 29.5579325 0.485372985 -1.042834281 0.235205616 1 0.39455499 0.199755649 171425 citramalyl-CoA lyase "GO:0000287,GO:0004474,GO:0005739,GO:0016787,GO:0047777,GO:0070207,GO:0106064,GO:0106121" magnesium ion binding|malate synthase activity|mitochondrion|hydrolase activity|(S)-citramalyl-CoA lyase activity|protein homotrimerization|regulation of cobalamin metabolic process|positive regulation of cobalamin metabolic process CMAS 1171.652843 988.5671132 1354.738573 1.370406273 0.45460366 0.185661636 1 28.64269841 40.94295629 55907 cytidine monophosphate N-acetylneuraminic acid synthetase "GO:0005634,GO:0005654,GO:0006054,GO:0008781,GO:0016020" nucleus|nucleoplasm|N-acetylneuraminate metabolic process|N-acylneuraminate cytidylyltransferase activity|membrane hsa00520 Amino sugar and nucleotide sugar metabolism CMBL 536.4032376 533.8668394 538.9396359 1.009501988 0.013643752 0.978066928 1 6.945407666 7.313425648 134147 carboxymethylenebutenolidase homolog "GO:0005829,GO:0006805,GO:0016787,GO:0070062" cytosol|xenobiotic metabolic process|hydrolase activity|extracellular exosome CMC1 437.3923286 433.3861985 441.3984586 1.018487576 0.026428381 0.95600463 1 2.091422778 2.221843672 152100 C-X9-C motif containing 1 "GO:0005739,GO:0046872" mitochondrion|metal ion binding CMC2 450.948498 417.146903 484.7500929 1.16206087 0.21668564 0.607955671 1 2.038893942 2.471379516 56942 C-X9-C motif containing 2 "GO:0005515,GO:0005739" protein binding|mitochondrion CMC4 70.94844056 68.00204988 73.89483124 1.086655937 0.119895219 0.892321536 1 3.909266662 4.431015639 100272147 C-X9-C motif containing 4 "GO:0005739,GO:0005758" mitochondrion|mitochondrial intermembrane space CMIP 988.3842589 920.5650633 1056.203455 1.147342536 0.198296169 0.575428579 1 3.962887624 4.742646791 80790 c-Maf inducing protein "GO:0001701,GO:0005515,GO:0005654,GO:0005829" in utero embryonic development|protein binding|nucleoplasm|cytosol CMPK1 2601.51474 2588.137719 2614.891762 1.010337179 0.014836842 0.964174345 1 44.63059077 47.03432328 51727 cytidine/uridine monophosphate kinase 1 "GO:0004127,GO:0004550,GO:0004849,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006163,GO:0006165,GO:0006207,GO:0006222,GO:0006225,GO:0009142,GO:0009220,GO:0015949,GO:0033862,GO:0046705,GO:0046940,GO:0070062" cytidylate kinase activity|nucleoside diphosphate kinase activity|uridine kinase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|'de novo' pyrimidine nucleobase biosynthetic process|UMP biosynthetic process|UDP biosynthetic process|nucleoside triphosphate biosynthetic process|pyrimidine ribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|UMP kinase activity|CDP biosynthetic process|nucleoside monophosphate phosphorylation|extracellular exosome "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes CMPK2 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.052279623 0.013234087 129607 cytidine/uridine monophosphate kinase 2 "GO:0004127,GO:0004550,GO:0004798,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0006165,GO:0006227,GO:0006233,GO:0006235,GO:0009041,GO:0009142,GO:0033862,GO:0046940,GO:0071222" cytidylate kinase activity|nucleoside diphosphate kinase activity|thymidylate kinase activity|ATP binding|nucleoplasm|cytoplasm|mitochondrion|nucleoside diphosphate phosphorylation|dUDP biosynthetic process|dTDP biosynthetic process|dTTP biosynthetic process|uridylate kinase activity|nucleoside triphosphate biosynthetic process|UMP kinase activity|nucleoside monophosphate phosphorylation|cellular response to lipopolysaccharide hsa00240 Pyrimidine metabolism CMSS1 573.0037572 577.509946 568.4975683 0.98439442 -0.022691615 0.958979317 1 6.696163332 6.875608049 84319 cms1 ribosomal small subunit homolog "GO:0003723,GO:0005515" RNA binding|protein binding CMTM1 24.62888881 33.49354696 15.76423066 0.470664713 -1.087228401 0.303319828 1 2.359290675 1.158267899 113540 CKLF like MARVEL transmembrane domain containing 1 "GO:0005125,GO:0005615,GO:0006935,GO:0007165,GO:0016021" cytokine activity|extracellular space|chemotaxis|signal transduction|integral component of membrane CMTM3 1420.033502 1668.587612 1171.479391 0.702078442 -0.510295865 0.126711417 1 35.97619248 26.34612607 123920 CKLF like MARVEL transmembrane domain containing 3 "GO:0005125,GO:0005515,GO:0005615,GO:0005829,GO:0006935,GO:0007165,GO:0016021,GO:0031410" cytokine activity|protein binding|extracellular space|cytosol|chemotaxis|signal transduction|integral component of membrane|cytoplasmic vesicle CMTM4 1031.704718 1120.511389 942.8980466 0.841489034 -0.248983624 0.478051386 1 6.437153917 5.650127968 146223 CKLF like MARVEL transmembrane domain containing 4 "GO:0005515,GO:0016021" protein binding|integral component of membrane CMTM6 4421.522296 4422.163154 4420.881437 0.999710161 -0.00041821 0.999769961 1 67.72511742 70.62196585 54918 CKLF like MARVEL transmembrane domain containing 6 "GO:0005515,GO:0005886,GO:0015031,GO:0016020,GO:0016021,GO:0031647,GO:0031901,GO:0032456,GO:0035577,GO:0035579,GO:0043231,GO:0043312,GO:0055038" protein binding|plasma membrane|protein transport|membrane|integral component of membrane|regulation of protein stability|early endosome membrane|endocytic recycling|azurophil granule membrane|specific granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|recycling endosome membrane CMTM7 1272.820349 1371.205513 1174.435185 0.856498295 -0.22347772 0.510336357 1 31.50940196 28.15027184 112616 CKLF like MARVEL transmembrane domain containing 7 "GO:0002337,GO:0005125,GO:0005515,GO:0005615,GO:0006935,GO:0007165,GO:0016020,GO:0016021" B-1a B cell differentiation|cytokine activity|protein binding|extracellular space|chemotaxis|signal transduction|membrane|integral component of membrane CMTM8 114.2082786 95.40586103 133.0106962 1.394156447 0.479392464 0.463150554 1 2.285700231 3.323890539 152189 CKLF like MARVEL transmembrane domain containing 8 "GO:0005125,GO:0005515,GO:0005615,GO:0005654,GO:0005737,GO:0006935,GO:0007165,GO:0016021,GO:0019911,GO:0042552" cytokine activity|protein binding|extracellular space|nucleoplasm|cytoplasm|chemotaxis|signal transduction|integral component of membrane|structural constituent of myelin sheath|myelination CMTR1 1177.684433 1165.169452 1190.199415 1.021481823 0.030663531 0.931304133 1 13.45149812 14.33234414 23070 cap methyltransferase 1 "GO:0003676,GO:0004483,GO:0005634,GO:0005654,GO:0005737,GO:0006370,GO:0043231,GO:0080009,GO:0097309" nucleic acid binding|mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleus|nucleoplasm|cytoplasm|7-methylguanosine mRNA capping|intracellular membrane-bounded organelle|mRNA methylation|cap1 mRNA methylation CMTR2 426.9134402 424.2515948 429.5752856 1.012548429 0.017990911 0.972378807 1 3.72647357 3.935770617 55783 cap methyltransferase 2 "GO:0004483,GO:0005634,GO:0005737,GO:0006370,GO:0097309,GO:0097310" mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleus|cytoplasm|7-methylguanosine mRNA capping|cap1 mRNA methylation|cap2 mRNA methylation CMYA5 8.986145956 8.119647747 9.852644165 1.213432463 0.279093814 0.926248221 1 0.031689259 0.040109165 202333 cardiomyopathy associated 5 "GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0016529,GO:0016607,GO:0031430,GO:0043231,GO:0048471" protein binding|nucleus|cytosol|plasma membrane|sarcoplasmic reticulum|nuclear speck|M band|intracellular membrane-bounded organelle|perinuclear region of cytoplasm CNBD2 15.58335975 21.31407534 9.852644165 0.462259986 -1.113223609 0.364402545 1 0.373007161 0.17985371 140894 cyclic nucleotide binding domain containing 2 "GO:0005829,GO:0007283,GO:0030552" cytosol|spermatogenesis|cAMP binding CNBP 3245.393947 3397.057626 3093.730268 0.910708798 -0.134938273 0.671782087 1 52.12026194 49.5110403 7555 CCHC-type zinc finger nucleic acid binding protein "GO:0000122,GO:0003697,GO:0003723,GO:0003727,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0006355,GO:0008270,GO:0008284,GO:0042632,GO:0045182,GO:0045893,GO:0045944,GO:0051880,GO:0071919,GO:2000767" "negative regulation of transcription by RNA polymerase II|single-stranded DNA binding|RNA binding|single-stranded RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|regulation of transcription, DNA-templated|zinc ion binding|positive regulation of cell population proliferation|cholesterol homeostasis|translation regulator activity|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|G-quadruplex DNA binding|G-quadruplex DNA formation|positive regulation of cytoplasmic translation" CNDP2 3174.203769 3548.286065 2800.121472 0.789147611 -0.341632912 0.282937199 1 33.07106581 27.22214653 55748 carnosine dipeptidase 2 "GO:0004180,GO:0005654,GO:0005829,GO:0006508,GO:0006750,GO:0008233,GO:0016805,GO:0046872,GO:0070062,GO:0070573,GO:0102008,GO:0103046" carboxypeptidase activity|nucleoplasm|cytosol|proteolysis|glutathione biosynthetic process|peptidase activity|dipeptidase activity|metal ion binding|extracellular exosome|metallodipeptidase activity|cytosolic dipeptidase activity|alanylglutamate dipeptidase activity "hsa00330,hsa00340,hsa00410" Arginine and proline metabolism|Histidine metabolism|beta-Alanine metabolism CNEP1R1 231.5504998 202.9911937 260.109806 1.281384681 0.357703648 0.488743746 1 4.797381171 6.412091096 255919 CTD nuclear envelope phosphatase 1 regulatory subunit 1 "GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0006629,GO:0007077,GO:0010867,GO:0016021,GO:0031965,GO:0034504,GO:0035307,GO:0071595" protein binding|nuclear envelope|cytoplasm|cytosol|lipid metabolic process|mitotic nuclear envelope disassembly|positive regulation of triglyceride biosynthetic process|integral component of membrane|nuclear membrane|protein localization to nucleus|positive regulation of protein dephosphorylation|Nem1-Spo7 phosphatase complex CNFN 18.03167502 20.29911937 15.76423066 0.776596776 -0.364762376 0.788034015 1 1.626706938 1.317713005 84518 cornifelin "GO:0001533,GO:0005515,GO:0005737,GO:0031424" cornified envelope|protein binding|cytoplasm|keratinization CNGA1 4.97085941 3.044867905 6.896850916 2.265073931 1.17955814 0.582594813 1 0.036848702 0.087060369 1259 cyclic nucleotide gated channel subunit alpha 1 "GO:0005222,GO:0005223,GO:0005515,GO:0005886,GO:0005887,GO:0007601,GO:0016056,GO:0022400,GO:0030553,GO:0042622,GO:0098655" intracellular cAMP-activated cation channel activity|intracellular cGMP-activated cation channel activity|protein binding|plasma membrane|integral component of plasma membrane|visual perception|rhodopsin mediated signaling pathway|regulation of rhodopsin mediated signaling pathway|cGMP binding|photoreceptor outer segment membrane|cation transmembrane transport "hsa04022,hsa04024,hsa04744" cGMP-PKG signaling pathway|cAMP signaling pathway|Phototransduction CNGA4 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.028581562 0.043410896 1262 cyclic nucleotide gated channel subunit alpha 4 "GO:0000139,GO:0005222,GO:0005223,GO:0007608,GO:0016021,GO:0030552,GO:0030553,GO:0030660,GO:0050896,GO:0060170,GO:0098655" Golgi membrane|intracellular cAMP-activated cation channel activity|intracellular cGMP-activated cation channel activity|sensory perception of smell|integral component of membrane|cAMP binding|cGMP binding|Golgi-associated vesicle membrane|response to stimulus|ciliary membrane|cation transmembrane transport "hsa04024,hsa04740" cAMP signaling pathway|Olfactory transduction CNGB1 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.030210955 0.007647614 1258 cyclic nucleotide gated channel subunit beta 1 "GO:0000139,GO:0001750,GO:0001895,GO:0005222,GO:0005223,GO:0005515,GO:0005886,GO:0006812,GO:0007601,GO:0007608,GO:0015276,GO:0016056,GO:0017071,GO:0022400,GO:0030552,GO:0030553,GO:0030660,GO:0033365,GO:0035845,GO:0043195,GO:0044877,GO:0045494,GO:0050908,GO:0051480,GO:0060170,GO:0098655,GO:1902495" Golgi membrane|photoreceptor outer segment|retina homeostasis|intracellular cAMP-activated cation channel activity|intracellular cGMP-activated cation channel activity|protein binding|plasma membrane|cation transport|visual perception|sensory perception of smell|ligand-gated ion channel activity|rhodopsin mediated signaling pathway|intracellular cyclic nucleotide activated cation channel complex|regulation of rhodopsin mediated signaling pathway|cAMP binding|cGMP binding|Golgi-associated vesicle membrane|protein localization to organelle|photoreceptor cell outer segment organization|terminal bouton|protein-containing complex binding|photoreceptor cell maintenance|detection of light stimulus involved in visual perception|regulation of cytosolic calcium ion concentration|ciliary membrane|cation transmembrane transport|transmembrane transporter complex "hsa04022,hsa04024,hsa04740,hsa04744" cGMP-PKG signaling pathway|cAMP signaling pathway|Olfactory transduction|Phototransduction CNGB3 15.10557332 22.3290313 7.882115332 0.352998535 -1.5022659 0.223975294 1 0.241952645 0.089087999 54714 cyclic nucleotide gated channel subunit beta 3 "GO:0001750,GO:0005222,GO:0005223,GO:0006812,GO:0007165,GO:0007601,GO:0030553,GO:0098655,GO:1902495" photoreceptor outer segment|intracellular cAMP-activated cation channel activity|intracellular cGMP-activated cation channel activity|cation transport|signal transduction|visual perception|cGMP binding|cation transmembrane transport|transmembrane transporter complex hsa04024 cAMP signaling pathway CNIH1 2009.731576 2006.567949 2012.895203 1.003153272 0.004542052 0.990500319 1 21.46263736 22.45775353 10175 cornichon family AMPA receptor auxiliary protein 1 "GO:0000139,GO:0005515,GO:0005789,GO:0006888,GO:0006955,GO:0007165,GO:0012507,GO:0016021,GO:0033116,GO:0048208" Golgi membrane|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|immune response|signal transduction|ER to Golgi transport vesicle membrane|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating CNIH2 71.97824231 71.04691779 72.90956682 1.026217169 0.037336067 0.981170247 1 2.618832422 2.803256997 254263 cornichon family AMPA receptor auxiliary protein 2 "GO:0000139,GO:0005515,GO:0005789,GO:0006888,GO:0012507,GO:0014069,GO:0030425,GO:0032281,GO:0033116,GO:0035249,GO:0042391,GO:0043197,GO:0043198,GO:0045202,GO:0045211,GO:0048208,GO:0051668,GO:0098962,GO:0098978,GO:0099061,GO:1902684,GO:1903743,GO:2000310,GO:2000311" "Golgi membrane|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|postsynaptic density|dendrite|AMPA glutamate receptor complex|endoplasmic reticulum-Golgi intermediate compartment membrane|synaptic transmission, glutamatergic|regulation of membrane potential|dendritic spine|dendritic shaft|synapse|postsynaptic membrane|COPII vesicle coating|localization within membrane|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse|integral component of postsynaptic density membrane|negative regulation of receptor localization to synapse|negative regulation of anterograde synaptic vesicle transport|regulation of NMDA receptor activity|regulation of AMPA receptor activity" CNIH3 484.9925764 690.1700585 279.8150943 0.405429199 -1.302478098 0.001794065 0.132156273 11.3195203 4.786950937 149111 cornichon family AMPA receptor auxiliary protein 3 "GO:0000139,GO:0005515,GO:0005789,GO:0006888,GO:0012507,GO:0016247,GO:0030425,GO:0032281,GO:0033116,GO:0035249,GO:0042391,GO:0043198,GO:0045202,GO:0045211,GO:0048208,GO:2000311" "Golgi membrane|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|channel regulator activity|dendrite|AMPA glutamate receptor complex|endoplasmic reticulum-Golgi intermediate compartment membrane|synaptic transmission, glutamatergic|regulation of membrane potential|dendritic shaft|synapse|postsynaptic membrane|COPII vesicle coating|regulation of AMPA receptor activity" CNIH4 1678.797785 1509.239525 1848.356045 1.224693639 0.292420899 0.371756472 1 17.20406429 21.97730568 29097 cornichon family AMPA receptor auxiliary protein 4 "GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0006888,GO:0015031,GO:0016021,GO:0030134,GO:0031730" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|integral component of membrane|COPII-coated ER to Golgi transport vesicle|CCR5 chemokine receptor binding CNKSR3 17.4796597 16.23929549 18.72002391 1.15276084 0.205093232 0.908562417 1 0.033425304 0.040191157 154043 CNKSR family member 3 "GO:0005515,GO:0005737,GO:0010765,GO:0016324,GO:0033137,GO:0070373" protein binding|cytoplasm|positive regulation of sodium ion transport|apical plasma membrane|negative regulation of peptidyl-serine phosphorylation|negative regulation of ERK1 and ERK2 cascade CNN1 5.970969603 4.059823873 7.882115332 1.941491941 0.957165719 0.632358107 1 0.085317741 0.172778967 1264 calponin 1 "GO:0003779,GO:0005515,GO:0005516,GO:0005856,GO:0005925,GO:0006940,GO:0031032,GO:1904706" actin binding|protein binding|calmodulin binding|cytoskeleton|focal adhesion|regulation of smooth muscle contraction|actomyosin structure organization|negative regulation of vascular associated smooth muscle cell proliferation CNN2 5142.582693 5388.401236 4896.76415 0.908760119 -0.138028571 0.667932026 1 125.2425486 118.7181407 1265 calponin 2 "GO:0001725,GO:0003779,GO:0005516,GO:0005576,GO:0005856,GO:0005911,GO:0005925,GO:0007010,GO:0016020,GO:0031032,GO:0032970,GO:0035580,GO:0035722,GO:0043312,GO:0045296,GO:0071260,GO:1904724" stress fiber|actin binding|calmodulin binding|extracellular region|cytoskeleton|cell-cell junction|focal adhesion|cytoskeleton organization|membrane|actomyosin structure organization|regulation of actin filament-based process|specific granule lumen|interleukin-12-mediated signaling pathway|neutrophil degranulation|cadherin binding|cellular response to mechanical stimulus|tertiary granule lumen CNN3 3889.775435 3903.520654 3876.030215 0.992957527 -0.010196086 0.975347758 1 41.28201093 42.75702172 1266 calponin 3 "GO:0003779,GO:0005516,GO:0005829,GO:0005912,GO:0005925,GO:0008017,GO:0014069,GO:0015629,GO:0030855,GO:0031032,GO:0032780,GO:0043025,GO:0043197,GO:0098609,GO:0098641" actin binding|calmodulin binding|cytosol|adherens junction|focal adhesion|microtubule binding|postsynaptic density|actin cytoskeleton|epithelial cell differentiation|actomyosin structure organization|negative regulation of ATPase activity|neuronal cell body|dendritic spine|cell-cell adhesion|cadherin binding involved in cell-cell adhesion CNNM2 1466.00492 1578.256531 1353.753308 0.857752388 -0.221366857 0.506008182 1 4.637030139 4.148754956 54805 cyclin and CBS domain divalent metal cation transport mediator 2 "GO:0005524,GO:0005886,GO:0006810,GO:0010960,GO:0015095,GO:0016021,GO:0016323,GO:0022857,GO:0043231,GO:1903830" ATP binding|plasma membrane|transport|magnesium ion homeostasis|magnesium ion transmembrane transporter activity|integral component of membrane|basolateral plasma membrane|transmembrane transporter activity|intracellular membrane-bounded organelle|magnesium ion transmembrane transport CNNM3 484.5311196 490.2237327 478.8385064 0.976775449 -0.033901156 0.939640572 1 3.567768739 3.635024653 26505 cyclin and CBS domain divalent metal cation transport mediator 3 "GO:0005515,GO:0005886,GO:0006810,GO:0006811,GO:0016020,GO:0016021,GO:0022857,GO:0043231,GO:0055085" protein binding|plasma membrane|transport|ion transport|membrane|integral component of membrane|transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport CNNM4 409.1517108 388.7281359 429.5752856 1.105078964 0.144149462 0.741875674 1 3.635772619 4.19088705 26504 cyclin and CBS domain divalent metal cation transport mediator 4 "GO:0005515,GO:0005886,GO:0006810,GO:0007601,GO:0010960,GO:0015081,GO:0015095,GO:0015693,GO:0016021,GO:0016323,GO:0022857,GO:0030425,GO:0032991,GO:0035725,GO:0043025,GO:0043231,GO:0050896,GO:0055065,GO:0070166,GO:1903830" protein binding|plasma membrane|transport|visual perception|magnesium ion homeostasis|sodium ion transmembrane transporter activity|magnesium ion transmembrane transporter activity|magnesium ion transport|integral component of membrane|basolateral plasma membrane|transmembrane transporter activity|dendrite|protein-containing complex|sodium ion transmembrane transport|neuronal cell body|intracellular membrane-bounded organelle|response to stimulus|metal ion homeostasis|enamel mineralization|magnesium ion transmembrane transport CNOT1 5948.899884 5784.234064 6113.565705 1.056936085 0.079888136 0.805679512 1 33.0458037 36.43182891 23019 CCR4-NOT transcription complex subunit 1 "GO:0000122,GO:0000288,GO:0000289,GO:0000932,GO:0001829,GO:0003723,GO:0004535,GO:0005515,GO:0005615,GO:0005634,GO:0005829,GO:0006977,GO:0010606,GO:0016020,GO:0017148,GO:0019904,GO:0030014,GO:0030015,GO:0030331,GO:0033147,GO:0035195,GO:0042974,GO:0048387,GO:0060090,GO:0060213,GO:0061014,GO:0070016,GO:0090503,GO:1900153,GO:2000036" "negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|P-body|trophectodermal cell differentiation|RNA binding|poly(A)-specific ribonuclease activity|protein binding|extracellular space|nucleus|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cytoplasmic mRNA processing body assembly|membrane|negative regulation of translation|protein domain specific binding|CCR4-NOT complex|CCR4-NOT core complex|estrogen receptor binding|negative regulation of intracellular estrogen receptor signaling pathway|gene silencing by miRNA|retinoic acid receptor binding|negative regulation of retinoic acid receptor signaling pathway|molecular adaptor activity|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mRNA catabolic process|armadillo repeat domain binding|RNA phosphodiester bond hydrolysis, exonucleolytic|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|regulation of stem cell population maintenance" hsa03018 RNA degradation CNOT10 992.1592915 942.8940946 1041.424488 1.104497837 0.143390594 0.686055522 1 15.05493681 17.3444182 25904 CCR4-NOT transcription complex subunit 10 "GO:0000289,GO:0005515,GO:0005634,GO:0005829,GO:0006402,GO:0006977,GO:0016020,GO:0017148,GO:0030014,GO:0031047" "nuclear-transcribed mRNA poly(A) tail shortening|protein binding|nucleus|cytosol|mRNA catabolic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|membrane|negative regulation of translation|CCR4-NOT complex|gene silencing by RNA" hsa03018 RNA degradation CNOT11 723.7086349 709.4542219 737.963048 1.040184166 0.056838982 0.882990678 1 14.28682049 15.50107281 55571 CCR4-NOT transcription complex subunit 11 "GO:0000289,GO:0003674,GO:0005515,GO:0005634,GO:0005829,GO:0006417,GO:0006977,GO:0030014,GO:0031047" "nuclear-transcribed mRNA poly(A) tail shortening|molecular_function|protein binding|nucleus|cytosol|regulation of translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|CCR4-NOT complex|gene silencing by RNA" CNOT2 1580.287427 1678.737172 1481.837682 0.882709758 -0.179988949 0.585505261 1 16.80278963 15.47088818 4848 CCR4-NOT transcription complex subunit 2 "GO:0000122,GO:0000289,GO:0000932,GO:0001226,GO:0001829,GO:0003712,GO:0004535,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006417,GO:0006977,GO:0010606,GO:0016020,GO:0030014,GO:0030015,GO:0031047,GO:0033147,GO:0090503,GO:2000036" "negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA polymerase II transcription corepressor binding|trophectodermal cell differentiation|transcription coregulator activity|poly(A)-specific ribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|regulation of translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cytoplasmic mRNA processing body assembly|membrane|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by RNA|negative regulation of intracellular estrogen receptor signaling pathway|RNA phosphodiester bond hydrolysis, exonucleolytic|regulation of stem cell population maintenance" hsa03018 RNA degradation CNOT3 1192.843947 1258.545401 1127.142493 0.895591444 -0.15908735 0.643289228 1 17.13004157 16.00236906 4849 CCR4-NOT transcription complex subunit 3 "GO:0000289,GO:0000932,GO:0001829,GO:0005515,GO:0005634,GO:0005829,GO:0006355,GO:0006417,GO:0006977,GO:0030014,GO:0030015,GO:0031047,GO:0120162,GO:2000036" "nuclear-transcribed mRNA poly(A) tail shortening|P-body|trophectodermal cell differentiation|protein binding|nucleus|cytosol|regulation of transcription, DNA-templated|regulation of translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by RNA|positive regulation of cold-induced thermogenesis|regulation of stem cell population maintenance" hsa03018 RNA degradation CNOT4 448.3462817 474.9993932 421.6931703 0.887776229 -0.171732014 0.685884307 1 4.403632357 4.077842956 4850 CCR4-NOT transcription complex subunit 4 "GO:0000289,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0006977,GO:0016567,GO:0030014,GO:0045652,GO:0046872,GO:0051865" "nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|protein ubiquitination|CCR4-NOT complex|regulation of megakaryocyte differentiation|metal ion binding|protein autoubiquitination" hsa03018 RNA degradation CNOT6 1705.727769 1700.051247 1711.404292 1.00667806 0.009602377 0.978545336 1 12.69935077 13.33484747 57472 CCR4-NOT transcription complex subunit 6 "GO:0000175,GO:0000289,GO:0003723,GO:0004532,GO:0004535,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006417,GO:0006977,GO:0008284,GO:0010606,GO:0016020,GO:0030014,GO:0030374,GO:0035195,GO:0043928,GO:0045893,GO:0046872,GO:0070966,GO:0090503" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|exoribonuclease activity|poly(A)-specific ribonuclease activity|protein binding|nucleus|cytoplasm|cytosol|regulation of translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cell population proliferation|positive regulation of cytoplasmic mRNA processing body assembly|membrane|CCR4-NOT complex|nuclear receptor coactivator activity|gene silencing by miRNA|exonucleolytic catabolism of deadenylated mRNA|positive regulation of transcription, DNA-templated|metal ion binding|nuclear-transcribed mRNA catabolic process, no-go decay|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation CNOT6L 904.5437495 779.4861837 1029.601315 1.320871796 0.401490445 0.263287274 1 3.801100072 5.237040109 246175 CCR4-NOT transcription complex subunit 6 like "GO:0000175,GO:0000289,GO:0004535,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006397,GO:0006977,GO:0008284,GO:0010606,GO:0030014,GO:0031047,GO:0046872,GO:0061157,GO:0090503" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|poly(A)-specific ribonuclease activity|protein binding|nucleus|cytoplasm|cytosol|mRNA processing|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cell population proliferation|positive regulation of cytoplasmic mRNA processing body assembly|CCR4-NOT complex|gene silencing by RNA|metal ion binding|mRNA destabilization|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation CNOT7 1357.826994 1490.970318 1224.68367 0.821400437 -0.283842381 0.398342668 1 6.608820826 5.662325572 29883 CCR4-NOT transcription complex subunit 7 "GO:0000175,GO:0000289,GO:0000290,GO:0000932,GO:0003714,GO:0003723,GO:0004532,GO:0004535,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006977,GO:0008134,GO:0008284,GO:0008285,GO:0010629,GO:0016020,GO:0016604,GO:0016607,GO:0017148,GO:0030014,GO:0030015,GO:0031047,GO:0033962,GO:0035195,GO:0042509,GO:0043928,GO:0045070,GO:0045892,GO:0045944,GO:0046872,GO:0051607,GO:0060213,GO:0060339,GO:0061014,GO:0090503,GO:1900153" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|transcription corepressor activity|RNA binding|exoribonuclease activity|poly(A)-specific ribonuclease activity|protein binding|nucleus|cytoplasm|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|transcription factor binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|negative regulation of gene expression|membrane|nuclear body|nuclear speck|negative regulation of translation|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by RNA|P-body assembly|gene silencing by miRNA|regulation of tyrosine phosphorylation of STAT protein|exonucleolytic catabolism of deadenylated mRNA|positive regulation of viral genome replication|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|defense response to virus|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|negative regulation of type I interferon-mediated signaling pathway|positive regulation of mRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" hsa03018 RNA degradation CNOT8 1658.83047 1794.442152 1523.218788 0.84885366 -0.236412237 0.470945014 1 25.10557033 22.22894478 9337 CCR4-NOT transcription complex subunit 8 "GO:0000175,GO:0000289,GO:0000932,GO:0003723,GO:0004535,GO:0005515,GO:0005634,GO:0005829,GO:0006351,GO:0006977,GO:0008284,GO:0017148,GO:0030014,GO:0030015,GO:0035195,GO:0043928,GO:0046872,GO:0061014,GO:0090503" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA binding|poly(A)-specific ribonuclease activity|protein binding|nucleus|cytosol|transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cell population proliferation|negative regulation of translation|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by miRNA|exonucleolytic catabolism of deadenylated mRNA|metal ion binding|positive regulation of mRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation CNOT9 1256.67285 1311.323111 1202.022588 0.916648672 -0.125559203 0.713013491 1 13.39800071 12.81028641 9125 CCR4-NOT transcription complex subunit 9 "GO:0000289,GO:0000932,GO:0005154,GO:0005515,GO:0005634,GO:0005829,GO:0006977,GO:0007548,GO:0016020,GO:0017148,GO:0019221,GO:0019900,GO:0019904,GO:0030014,GO:0030015,GO:0030374,GO:0031047,GO:0032991,GO:0033138,GO:0033147,GO:0042803,GO:0045742,GO:0045893" "nuclear-transcribed mRNA poly(A) tail shortening|P-body|epidermal growth factor receptor binding|protein binding|nucleus|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|sex differentiation|membrane|negative regulation of translation|cytokine-mediated signaling pathway|kinase binding|protein domain specific binding|CCR4-NOT complex|CCR4-NOT core complex|nuclear receptor coactivator activity|gene silencing by RNA|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|negative regulation of intracellular estrogen receptor signaling pathway|protein homodimerization activity|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of transcription, DNA-templated" hsa03018 RNA degradation CNP 2316.804499 2388.191394 2245.417605 0.940216773 -0.088934677 0.78181638 1 22.17295491 21.74540487 1267 "2',3'-cyclic nucleotide 3' phosphodiesterase" "GO:0000226,GO:0003723,GO:0004113,GO:0005515,GO:0005615,GO:0005737,GO:0005741,GO:0005743,GO:0005886,GO:0005902,GO:0007268,GO:0007409,GO:0007568,GO:0008344,GO:0009214,GO:0009636,GO:0016020,GO:0021762,GO:0030551,GO:0030900,GO:0031143,GO:0032496,GO:0035748,GO:0035749,GO:0042470,GO:0045202,GO:0046902,GO:0048471,GO:0048709,GO:0070062" "microtubule cytoskeleton organization|RNA binding|2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|protein binding|extracellular space|cytoplasm|mitochondrial outer membrane|mitochondrial inner membrane|plasma membrane|microvillus|chemical synaptic transmission|axonogenesis|aging|adult locomotory behavior|cyclic nucleotide catabolic process|response to toxic substance|membrane|substantia nigra development|cyclic nucleotide binding|forebrain development|pseudopodium|response to lipopolysaccharide|myelin sheath abaxonal region|myelin sheath adaxonal region|melanosome|synapse|regulation of mitochondrial membrane permeability|perinuclear region of cytoplasm|oligodendrocyte differentiation|extracellular exosome" CNPPD1 903.478813 841.3984978 965.5591282 1.147564597 0.198575366 0.581175031 1 16.68514708 19.97207143 27013 cyclin Pas1/PHO80 domain containing 1 "GO:0000079,GO:0000307,GO:0005634,GO:0016021,GO:0016538,GO:0019901" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|nucleus|integral component of membrane|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding CNPY2 2332.055809 2454.163532 2209.948086 0.900489335 -0.151218905 0.636697719 1 57.43748849 53.94981317 10330 canopy FGF signaling regulator 2 "GO:0005515,GO:0005783,GO:0010629,GO:0010988,GO:1905599" protein binding|endoplasmic reticulum|negative regulation of gene expression|regulation of low-density lipoprotein particle clearance|positive regulation of low-density lipoprotein receptor activity CNPY3 799.1501485 781.5160956 816.7842013 1.045127805 0.063679375 0.865490187 1 15.37127504 16.75695969 10695 canopy FGF signaling regulator 3 "GO:0002224,GO:0005102,GO:0005515,GO:0005788,GO:0045087" toll-like receptor signaling pathway|signaling receptor binding|protein binding|endoplasmic reticulum lumen|innate immune response CNPY4 567.7184149 586.6445497 548.79228 0.935476653 -0.096226446 0.811635895 1 20.10248774 19.61546866 245812 canopy FGF signaling regulator 4 "GO:0003674,GO:0005102,GO:0005515,GO:0005576,GO:1903078" molecular_function|signaling receptor binding|protein binding|extracellular region|positive regulation of protein localization to plasma membrane CNRIP1 6.508139139 7.104691779 5.911586499 0.832067975 -0.265226703 0.975312627 1 0.162817907 0.141311304 25927 cannabinoid receptor interacting protein 1 "GO:0005515,GO:0005737,GO:0005886,GO:0008022,GO:0031718,GO:2000272" protein binding|cytoplasm|plasma membrane|protein C-terminus binding|type 1 cannabinoid receptor binding|negative regulation of signaling receptor activity CNST 650.4400479 718.5888256 582.2912702 0.810326086 -0.303425511 0.429895414 1 6.275907741 5.304595836 163882 "consortin, connexin sorting protein" "GO:0005515,GO:0005802,GO:0005886,GO:0010923,GO:0016020,GO:0016021,GO:0019902,GO:0030133,GO:0032991,GO:0042998,GO:0043231,GO:0071253" protein binding|trans-Golgi network|plasma membrane|negative regulation of phosphatase activity|membrane|integral component of membrane|phosphatase binding|transport vesicle|protein-containing complex|positive regulation of Golgi to plasma membrane protein transport|intracellular membrane-bounded organelle|connexin binding CNTD1 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.107123422 0.061982332 124817 cyclin N-terminal domain containing 1 "GO:0007131,GO:0007283,GO:0035861" reciprocal meiotic recombination|spermatogenesis|site of double-strand break CNTF 56.09524543 62.92727004 49.26322083 0.782859654 -0.353174402 0.678359545 1 1.675627883 1.368287689 1270 ciliary neurotrophic factor "GO:0005125,GO:0005127,GO:0005138,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0007165,GO:0008083,GO:0008284,GO:0010628,GO:0019221,GO:0030424,GO:0042531,GO:0043524,GO:0044877,GO:0046533,GO:0046668,GO:0048143,GO:0048644,GO:0048666,GO:0048680,GO:0070120" cytokine activity|ciliary neurotrophic factor receptor binding|interleukin-6 receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|signal transduction|growth factor activity|positive regulation of cell population proliferation|positive regulation of gene expression|cytokine-mediated signaling pathway|axon|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of neuron apoptotic process|protein-containing complex binding|negative regulation of photoreceptor cell differentiation|regulation of retinal cell programmed cell death|astrocyte activation|muscle organ morphogenesis|neuron development|positive regulation of axon regeneration|ciliary neurotrophic factor-mediated signaling pathway "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway CNTLN 390.9688564 391.7730038 390.164709 0.99589483 -0.005934698 0.995855925 1 1.353011971 1.405500636 54875 centlein "GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0010457,GO:0019901,GO:0019904,GO:0030674,GO:0033365,GO:0070062" nucleoplasm|cytoplasm|centrosome|centriole|cytosol|centriole-centriole cohesion|protein kinase binding|protein domain specific binding|protein-macromolecule adaptor activity|protein localization to organelle|extracellular exosome CNTNAP1 2904.645368 2801.278473 3008.012264 1.0737998 0.102725041 0.747496566 1 16.61492825 18.60962915 8506 contactin associated protein 1 "GO:0002175,GO:0005515,GO:0005887,GO:0007010,GO:0007155,GO:0007165,GO:0016021,GO:0017124,GO:0019227,GO:0022010,GO:0022011,GO:0030913,GO:0033010,GO:0033270,GO:0038023,GO:0048787,GO:0048812,GO:0050884,GO:0050885,GO:0071205" protein localization to paranode region of axon|protein binding|integral component of plasma membrane|cytoskeleton organization|cell adhesion|signal transduction|integral component of membrane|SH3 domain binding|neuronal action potential propagation|central nervous system myelination|myelination in peripheral nervous system|paranodal junction assembly|paranodal junction|paranode region of axon|signaling receptor activity|presynaptic active zone membrane|neuron projection morphogenesis|neuromuscular process controlling posture|neuromuscular process controlling balance|protein localization to juxtaparanode region of axon hsa04514 Cell adhesion molecules CNTNAP3 167.6594921 179.6472064 155.6717778 0.866541601 -0.206659083 0.724260142 1 0.691900931 0.625387594 79937 contactin associated protein family member 3 "GO:0005576,GO:0005886,GO:0007155,GO:0008037,GO:0016021" extracellular region|plasma membrane|cell adhesion|cell recognition|integral component of membrane CNTNAP3B 10.00110192 10.14955968 9.852644165 0.970745971 -0.042834281 1 1 0.067177129 0.068020993 728577 contactin associated protein family member 3B "GO:0007155,GO:0016021" cell adhesion|integral component of membrane CNTNAP3C 31.82537685 20.29911937 43.35163433 2.135641135 1.094669242 0.263028742 1 0.214004743 0.476724647 100289279 CNTRL 663.7992629 554.1659587 773.432567 1.395669573 0.480957422 0.208334776 1 3.369738364 4.905629248 11064 centriolin "GO:0000086,GO:0001822,GO:0003281,GO:0005515,GO:0005813,GO:0005815,GO:0005829,GO:0008092,GO:0010389,GO:0016020,GO:0035904,GO:0048471,GO:0051301,GO:0051493,GO:0060976,GO:0090543,GO:0090619,GO:0097431,GO:0097711,GO:0120103" G2/M transition of mitotic cell cycle|kidney development|ventricular septum development|protein binding|centrosome|microtubule organizing center|cytosol|cytoskeletal protein binding|regulation of G2/M transition of mitotic cell cycle|membrane|aorta development|perinuclear region of cytoplasm|cell division|regulation of cytoskeleton organization|coronary vasculature development|Flemming body|meiotic spindle pole|mitotic spindle pole|ciliary basal body-plasma membrane docking|centriolar subdistal appendage CNTROB 1144.011499 917.5201954 1370.502803 1.493703147 0.578893461 0.093408143 1 11.00904077 17.15258996 116840 "centrobin, centriole duplication and spindle assembly protein" "GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0019904,GO:0051299,GO:1902017,GO:1902410" protein binding|centrosome|centriole|cytosol|centriole replication|protein domain specific binding|centrosome separation|regulation of cilium assembly|mitotic cytokinetic process COA1 1518.211809 1543.748028 1492.675591 0.966916598 -0.048536641 0.885268714 1 5.577897667 5.62568599 55744 cytochrome c oxidase assembly factor 1 homolog "GO:0005739,GO:0005829,GO:0031305,GO:0032981,GO:0033617" mitochondrion|cytosol|integral component of mitochondrial inner membrane|mitochondrial respiratory chain complex I assembly|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COA3 934.0435367 943.9090506 924.1780227 0.979096473 -0.030477075 0.934999925 1 61.28931218 62.59305712 28958 cytochrome c oxidase assembly factor 3 "GO:0005515,GO:0005739,GO:0031305,GO:0033617,GO:0070131" protein binding|mitochondrion|integral component of mitochondrial inner membrane|mitochondrial cytochrome c oxidase assembly|positive regulation of mitochondrial translation hsa04714 Thermogenesis COA4 876.8927573 1010.896145 742.8893701 0.73488199 -0.4444155 0.218257318 1 13.72977299 10.52438896 51287 cytochrome c oxidase assembly factor 4 homolog "GO:0005739,GO:0005758,GO:0033617" mitochondrion|mitochondrial intermembrane space|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COA5 299.1071764 308.5466144 289.6677385 0.938813537 -0.09108945 0.853691783 1 8.82869917 8.645537362 493753 cytochrome c oxidase assembly factor 5 "GO:0005515,GO:0005739,GO:0033617" protein binding|mitochondrion|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COA6 305.9446442 304.4867905 307.402498 1.009575809 0.013749247 0.984490451 1 12.26824326 12.91924827 388753 cytochrome c oxidase assembly factor 6 "GO:0003723,GO:0005507,GO:0005515,GO:0005654,GO:0005739,GO:0005758,GO:0005886,GO:0008535,GO:0042774,GO:0045277" RNA binding|copper ion binding|protein binding|nucleoplasm|mitochondrion|mitochondrial intermembrane space|plasma membrane|respiratory chain complex IV assembly|plasma membrane ATP synthesis coupled electron transport|respiratory chain complex IV hsa04714 Thermogenesis COA7 847.4657152 1053.524295 641.4071352 0.60882045 -0.715911276 0.049246535 1 13.37946062 8.496572486 65260 cytochrome c oxidase assembly factor 7 "GO:0005515,GO:0005654,GO:0005739,GO:0005758" protein binding|nucleoplasm|mitochondrion|mitochondrial intermembrane space hsa04714 Thermogenesis COA8 452.4088272 449.625494 455.1921604 1.012380674 0.017751872 0.972047617 1 13.65224526 14.41663347 84334 cytochrome c oxidase assembly factor 8 "GO:0000302,GO:0005739,GO:0033617,GO:0050821,GO:0097193,GO:0099617,GO:1903427,GO:1904960" response to reactive oxygen species|mitochondrion|mitochondrial cytochrome c oxidase assembly|protein stabilization|intrinsic apoptotic signaling pathway|matrix side of mitochondrial inner membrane|negative regulation of reactive oxygen species biosynthetic process|positive regulation of cytochrome-c oxidase activity COASY 2260.631066 2185.2002 2336.061932 1.069037945 0.096313062 0.764358496 1 46.99476909 52.403292 80347 Coenzyme A synthase "GO:0004140,GO:0004595,GO:0005515,GO:0005524,GO:0005741,GO:0005759,GO:0015937,GO:0016310,GO:0070062" dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity|protein binding|ATP binding|mitochondrial outer membrane|mitochondrial matrix|coenzyme A biosynthetic process|phosphorylation|extracellular exosome hsa00770 Pantothenate and CoA biosynthesis COBLL1 114.0125619 115.7049804 112.3201435 0.970745971 -0.042834281 0.962042884 1 0.562115019 0.569176179 22837 cordon-bleu WH2 repeat protein like 1 "GO:0003785,GO:0045296,GO:0070062" actin monomer binding|cadherin binding|extracellular exosome COCH 1159.836351 1090.06271 1229.609992 1.128017664 0.17378966 0.614321536 1 20.78608086 24.4570709 1690 cochlin "GO:0005515,GO:0005518,GO:0007605,GO:0008360,GO:0042742,GO:0045089,GO:0062023" protein binding|collagen binding|sensory perception of sound|regulation of cell shape|defense response to bacterium|positive regulation of innate immune response|collagen-containing extracellular matrix COG1 1045.779252 971.3128617 1120.245642 1.15333142 0.205807143 0.557081287 1 16.32168874 19.63519165 9382 component of oligomeric golgi complex 1 "GO:0000139,GO:0005515,GO:0005794,GO:0006888,GO:0006891,GO:0007030,GO:0015031,GO:0017119,GO:0032588" Golgi membrane|protein binding|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi organization|protein transport|Golgi transport complex|trans-Golgi network membrane COG2 586.1482042 667.8410272 504.4553813 0.755352488 -0.404778055 0.303402131 1 11.53608186 9.089163649 22796 component of oligomeric golgi complex 2 "GO:0000139,GO:0005515,GO:0005795,GO:0005829,GO:0006888,GO:0006891,GO:0007030,GO:0015031,GO:0017119,GO:0032588,GO:0044877" Golgi membrane|protein binding|Golgi stack|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi organization|protein transport|Golgi transport complex|trans-Golgi network membrane|protein-containing complex binding COG3 677.3687942 740.9178569 613.8197315 0.828458547 -0.271498582 0.476272971 1 8.335156742 7.202785537 83548 component of oligomeric golgi complex 3 "GO:0000139,GO:0005515,GO:0005794,GO:0005801,GO:0005829,GO:0005886,GO:0006486,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0007030,GO:0017119,GO:0032580,GO:0032588,GO:0033365,GO:0050821" "Golgi membrane|protein binding|Golgi apparatus|cis-Golgi network|cytosol|plasma membrane|protein glycosylation|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|Golgi organization|Golgi transport complex|Golgi cisterna membrane|trans-Golgi network membrane|protein localization to organelle|protein stabilization" COG4 678.2622624 768.3216681 588.2028567 0.765568487 -0.38539665 0.311093244 1 12.98391125 10.36825133 25839 component of oligomeric golgi complex 4 "GO:0000139,GO:0005515,GO:0005829,GO:0006888,GO:0006890,GO:0007030,GO:0015031,GO:0017119,GO:0032588,GO:0048213" "Golgi membrane|protein binding|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|protein transport|Golgi transport complex|trans-Golgi network membrane|Golgi vesicle prefusion complex stabilization" COG5 1308.258939 1200.692911 1415.824967 1.179173254 0.237775707 0.481806593 1 6.706093971 8.248275998 10466 component of oligomeric golgi complex 5 "GO:0000139,GO:0003674,GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0006888,GO:0006891,GO:0015031,GO:0016020,GO:0017119,GO:0032588,GO:0048219" Golgi membrane|molecular_function|protein binding|nucleoplasm|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|protein transport|membrane|Golgi transport complex|trans-Golgi network membrane|inter-Golgi cisterna vesicle-mediated transport COG6 573.1373692 586.6445497 559.6301886 0.953951058 -0.068012844 0.867381404 1 4.219780839 4.198865074 57511 component of oligomeric golgi complex 6 "GO:0000139,GO:0005515,GO:0006888,GO:0006891,GO:0015031,GO:0017119,GO:0032588,GO:0070085" Golgi membrane|protein binding|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|protein transport|Golgi transport complex|trans-Golgi network membrane|glycosylation COG7 383.7899357 372.4888404 395.091031 1.06067884 0.084987892 0.851716394 1 6.250909776 6.915810188 91949 component of oligomeric golgi complex 7 "GO:0000139,GO:0005515,GO:0005730,GO:0005794,GO:0006486,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0017119,GO:0032588,GO:0033365,GO:0034067,GO:0043231,GO:0050821" "Golgi membrane|protein binding|nucleolus|Golgi apparatus|protein glycosylation|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|Golgi transport complex|trans-Golgi network membrane|protein localization to organelle|protein localization to Golgi apparatus|intracellular membrane-bounded organelle|protein stabilization" COG8 450.6137261 495.2985126 405.9289396 0.819564221 -0.287071092 0.495384906 1 5.115237021 4.372851029 84342 component of oligomeric golgi complex 8 "GO:0000139,GO:0005515,GO:0005794,GO:0006888,GO:0006891,GO:0015031,GO:0016020,GO:0017119,GO:0032588" Golgi membrane|protein binding|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|protein transport|membrane|Golgi transport complex|trans-Golgi network membrane COIL 377.3236123 401.9225635 352.7246611 0.877593579 -0.188375124 0.672623827 1 7.728154876 7.074327869 8161 coilin "GO:0000387,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0008022,GO:0015030,GO:0016020,GO:0016604,GO:0030619,GO:0030620,GO:0042802" spliceosomal snRNP assembly|fibrillar center|protein binding|nucleus|nucleoplasm|nucleolus|protein C-terminus binding|Cajal body|membrane|nuclear body|U1 snRNA binding|U2 snRNA binding|identical protein binding COL11A2 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.041898879 0.024242973 1302 collagen type XI alpha 2 chain "GO:0001501,GO:0005201,GO:0005515,GO:0005576,GO:0005581,GO:0005592,GO:0005615,GO:0005788,GO:0007605,GO:0030020,GO:0030198,GO:0030199,GO:0030674,GO:0031012,GO:0046872,GO:0051216,GO:0060021,GO:0060023,GO:0062023" skeletal system development|extracellular matrix structural constituent|protein binding|extracellular region|collagen trimer|collagen type XI trimer|extracellular space|endoplasmic reticulum lumen|sensory perception of sound|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|collagen fibril organization|protein-macromolecule adaptor activity|extracellular matrix|metal ion binding|cartilage development|roof of mouth development|soft palate development|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL12A1 2754.694903 2754.590498 2754.799309 1.000075805 0.000109359 1 1 11.84901402 12.36035839 1303 collagen type XII alpha 1 chain "GO:0005576,GO:0005595,GO:0005615,GO:0005788,GO:0007155,GO:0030020,GO:0030199,GO:0035987,GO:0062023,GO:0070062,GO:1903561" extracellular region|collagen type XII trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|extracellular matrix structural constituent conferring tensile strength|collagen fibril organization|endodermal cell differentiation|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle hsa04974 Protein digestion and absorption COL13A1 29.98846 29.43372308 30.54319691 1.037693968 0.053381034 0.995534708 1 0.432969573 0.468643501 1305 collagen type XIII alpha 1 chain "GO:0001501,GO:0001763,GO:0001958,GO:0005201,GO:0005515,GO:0005576,GO:0005581,GO:0005600,GO:0005615,GO:0005788,GO:0005886,GO:0005911,GO:0007160,GO:0008201,GO:0030020,GO:0030154,GO:0030198,GO:0030199,GO:0030574,GO:0030903,GO:0031012,GO:0045211,GO:0062023,GO:0098609" skeletal system development|morphogenesis of a branching structure|endochondral ossification|extracellular matrix structural constituent|protein binding|extracellular region|collagen trimer|collagen type XIII trimer|extracellular space|endoplasmic reticulum lumen|plasma membrane|cell-cell junction|cell-matrix adhesion|heparin binding|extracellular matrix structural constituent conferring tensile strength|cell differentiation|extracellular matrix organization|collagen fibril organization|collagen catabolic process|notochord development|extracellular matrix|postsynaptic membrane|collagen-containing extracellular matrix|cell-cell adhesion hsa04974 Protein digestion and absorption COL14A1 6.493293363 6.08973581 6.896850916 1.132536966 0.17955814 1 1 0.034483859 0.040736544 7373 collagen type XIV alpha 1 chain "GO:0003723,GO:0005201,GO:0005518,GO:0005576,GO:0005581,GO:0005596,GO:0005614,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0030199,GO:0030674,GO:0031012,GO:0062023,GO:0098609" RNA binding|extracellular matrix structural constituent|collagen binding|extracellular region|collagen trimer|collagen type XIV trimer|interstitial matrix|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|collagen fibril organization|protein-macromolecule adaptor activity|extracellular matrix|collagen-containing extracellular matrix|cell-cell adhesion hsa04974 Protein digestion and absorption COL16A1 67.5566766 105.5554207 29.5579325 0.280022876 -1.836383404 0.0201165 0.615483166 0.871253208 0.254480103 1307 collagen type XVI alpha 1 chain "GO:0005178,GO:0005201,GO:0005515,GO:0005576,GO:0005588,GO:0005597,GO:0005615,GO:0005788,GO:0007155,GO:0007229,GO:0007565,GO:0030020,GO:0030198,GO:0031012,GO:0033622,GO:0033627,GO:0051894,GO:0062023,GO:0071230" integrin binding|extracellular matrix structural constituent|protein binding|extracellular region|collagen type V trimer|collagen type XVI trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|integrin-mediated signaling pathway|female pregnancy|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|integrin activation|cell adhesion mediated by integrin|positive regulation of focal adhesion assembly|collagen-containing extracellular matrix|cellular response to amino acid stimulus hsa04974 Protein digestion and absorption COL17A1 57.43680847 87.28621328 27.58740366 0.316056828 -1.661744114 0.044311675 0.956370134 0.787729646 0.259691836 1308 collagen type XVII alpha 1 chain "GO:0005201,GO:0005515,GO:0005576,GO:0005581,GO:0005604,GO:0005615,GO:0005788,GO:0005886,GO:0005887,GO:0005911,GO:0007160,GO:0008544,GO:0030020,GO:0030056,GO:0030198,GO:0031012,GO:0031581,GO:0050776,GO:0062023" extracellular matrix structural constituent|protein binding|extracellular region|collagen trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|cell-cell junction|cell-matrix adhesion|epidermis development|extracellular matrix structural constituent conferring tensile strength|hemidesmosome|extracellular matrix organization|extracellular matrix|hemidesmosome assembly|regulation of immune response|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL18A1 3689.024223 4223.231784 3154.816662 0.747014804 -0.420791262 0.186509039 1 35.27821066 27.48854085 80781 collagen type XVIII alpha 1 chain "GO:0001525,GO:0001886,GO:0005201,GO:0005576,GO:0005581,GO:0005604,GO:0005615,GO:0005788,GO:0007155,GO:0007601,GO:0008285,GO:0009887,GO:0030020,GO:0030198,GO:0031012,GO:0042493,GO:0046872,GO:0051599,GO:0062023,GO:0070062" angiogenesis|endothelial cell morphogenesis|extracellular matrix structural constituent|extracellular region|collagen trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|cell adhesion|visual perception|negative regulation of cell population proliferation|animal organ morphogenesis|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|response to drug|metal ion binding|response to hydrostatic pressure|collagen-containing extracellular matrix|extracellular exosome hsa04974 Protein digestion and absorption COL19A1 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.011379266 0 1310 collagen type XIX alpha 1 chain "GO:0001501,GO:0005201,GO:0005576,GO:0005581,GO:0005615,GO:0005788,GO:0007155,GO:0007519,GO:0030020,GO:0030154,GO:0030198,GO:0030574,GO:0030674,GO:0031012,GO:0062023,GO:0098609" skeletal system development|extracellular matrix structural constituent|extracellular region|collagen trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|skeletal muscle tissue development|extracellular matrix structural constituent conferring tensile strength|cell differentiation|extracellular matrix organization|collagen catabolic process|protein-macromolecule adaptor activity|extracellular matrix|collagen-containing extracellular matrix|cell-cell adhesion hsa04974 Protein digestion and absorption COL1A1 136.5994146 110.6302006 162.5686287 1.469477845 0.555303608 0.365194398 1 0.946617567 1.450953626 1277 collagen type I alpha 1 chain "GO:0001501,GO:0001503,GO:0001568,GO:0001649,GO:0001957,GO:0001958,GO:0002020,GO:0005201,GO:0005515,GO:0005576,GO:0005584,GO:0005615,GO:0005737,GO:0005788,GO:0005794,GO:0007596,GO:0007601,GO:0007605,GO:0009612,GO:0010718,GO:0010812,GO:0015031,GO:0030020,GO:0030141,GO:0030168,GO:0030198,GO:0030199,GO:0030335,GO:0031012,GO:0031960,GO:0032355,GO:0032964,GO:0034504,GO:0034505,GO:0038063,GO:0042493,GO:0042542,GO:0042802,GO:0043434,GO:0043588,GO:0043589,GO:0044344,GO:0044691,GO:0045893,GO:0046872,GO:0048407,GO:0048706,GO:0050776,GO:0050900,GO:0051591,GO:0055093,GO:0060325,GO:0060346,GO:0060351,GO:0062023,GO:0071230,GO:0071260,GO:0071300,GO:0071306,GO:0071356,GO:0071364,GO:0071560,GO:0090263,GO:1902618" "skeletal system development|ossification|blood vessel development|osteoblast differentiation|intramembranous ossification|endochondral ossification|protease binding|extracellular matrix structural constituent|protein binding|extracellular region|collagen type I trimer|extracellular space|cytoplasm|endoplasmic reticulum lumen|Golgi apparatus|blood coagulation|visual perception|sensory perception of sound|response to mechanical stimulus|positive regulation of epithelial to mesenchymal transition|negative regulation of cell-substrate adhesion|protein transport|extracellular matrix structural constituent conferring tensile strength|secretory granule|platelet activation|extracellular matrix organization|collagen fibril organization|positive regulation of cell migration|extracellular matrix|response to corticosteroid|response to estradiol|collagen biosynthetic process|protein localization to nucleus|tooth mineralization|collagen-activated tyrosine kinase receptor signaling pathway|response to drug|response to hydrogen peroxide|identical protein binding|response to peptide hormone|skin development|skin morphogenesis|cellular response to fibroblast growth factor stimulus|tooth eruption|positive regulation of transcription, DNA-templated|metal ion binding|platelet-derived growth factor binding|embryonic skeletal system development|regulation of immune response|leukocyte migration|response to cAMP|response to hyperoxia|face morphogenesis|bone trabecula formation|cartilage development involved in endochondral bone morphogenesis|collagen-containing extracellular matrix|cellular response to amino acid stimulus|cellular response to mechanical stimulus|cellular response to retinoic acid|cellular response to vitamin E|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of canonical Wnt signaling pathway|cellular response to fluoride" "hsa04151,hsa04510,hsa04512,hsa04611,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05205" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Proteoglycans in cancer COL1A2 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.030786473 1278 collagen type I alpha 2 chain "GO:0001501,GO:0001568,GO:0002020,GO:0005201,GO:0005515,GO:0005576,GO:0005584,GO:0005615,GO:0005783,GO:0005788,GO:0007179,GO:0007266,GO:0007596,GO:0008217,GO:0019221,GO:0030020,GO:0030168,GO:0030198,GO:0030199,GO:0030282,GO:0030674,GO:0031012,GO:0032963,GO:0042476,GO:0042802,GO:0043589,GO:0046332,GO:0046872,GO:0048407,GO:0050776,GO:0050900,GO:0062023,GO:0070062,GO:0070208,GO:0071230,GO:0085029" skeletal system development|blood vessel development|protease binding|extracellular matrix structural constituent|protein binding|extracellular region|collagen type I trimer|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|transforming growth factor beta receptor signaling pathway|Rho protein signal transduction|blood coagulation|regulation of blood pressure|cytokine-mediated signaling pathway|extracellular matrix structural constituent conferring tensile strength|platelet activation|extracellular matrix organization|collagen fibril organization|bone mineralization|protein-macromolecule adaptor activity|extracellular matrix|collagen metabolic process|odontogenesis|identical protein binding|skin morphogenesis|SMAD binding|metal ion binding|platelet-derived growth factor binding|regulation of immune response|leukocyte migration|collagen-containing extracellular matrix|extracellular exosome|protein heterotrimerization|cellular response to amino acid stimulus|extracellular matrix assembly "hsa04151,hsa04510,hsa04512,hsa04611,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05205" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Proteoglycans in cancer COL24A1 4.97085941 3.044867905 6.896850916 2.265073931 1.17955814 0.582594813 1 0.016718541 0.039499962 255631 collagen type XXIV alpha 1 chain "GO:0005201,GO:0005515,GO:0005576,GO:0005581,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0031012,GO:0062023" extracellular matrix structural constituent|protein binding|extracellular region|collagen trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL27A1 1088.366824 1188.513439 988.2202098 0.83147584 -0.266253751 0.443856292 1 6.706106602 5.816155604 85301 collagen type XXVII alpha 1 chain "GO:0003431,GO:0005201,GO:0005576,GO:0005583,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0031012,GO:0046872,GO:0062023" growth plate cartilage chondrocyte development|extracellular matrix structural constituent|extracellular region|fibrillar collagen trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|metal ion binding|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL2A1 9.49362394 9.134603715 9.852644165 1.078606634 0.109168812 1 1 0.078108299 0.087877197 1280 collagen type II alpha 1 chain "GO:0001501,GO:0001502,GO:0001894,GO:0001958,GO:0002062,GO:0003007,GO:0005201,GO:0005576,GO:0005581,GO:0005585,GO:0005604,GO:0005615,GO:0005788,GO:0006029,GO:0007417,GO:0007601,GO:0007605,GO:0010468,GO:0030020,GO:0030198,GO:0030199,GO:0030903,GO:0031012,GO:0042289,GO:0042472,GO:0042802,GO:0043394,GO:0046872,GO:0048407,GO:0050776,GO:0051216,GO:0060021,GO:0060174,GO:0060272,GO:0060351,GO:0062023,GO:0071599,GO:0071773,GO:0097065,GO:2001240" skeletal system development|cartilage condensation|tissue homeostasis|endochondral ossification|chondrocyte differentiation|heart morphogenesis|extracellular matrix structural constituent|extracellular region|collagen trimer|collagen type II trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|proteoglycan metabolic process|central nervous system development|visual perception|sensory perception of sound|regulation of gene expression|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|collagen fibril organization|notochord development|extracellular matrix|MHC class II protein binding|inner ear morphogenesis|identical protein binding|proteoglycan binding|metal ion binding|platelet-derived growth factor binding|regulation of immune response|cartilage development|roof of mouth development|limb bud formation|embryonic skeletal joint morphogenesis|cartilage development involved in endochondral bone morphogenesis|collagen-containing extracellular matrix|otic vesicle development|cellular response to BMP stimulus|anterior head development|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL3A1 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.028089584 0.018961626 1281 collagen type III alpha 1 chain "GO:0001501,GO:0002020,GO:0005178,GO:0005201,GO:0005515,GO:0005576,GO:0005586,GO:0005615,GO:0005788,GO:0007160,GO:0007179,GO:0007229,GO:0007507,GO:0009314,GO:0009612,GO:0018149,GO:0021987,GO:0030020,GO:0030168,GO:0030198,GO:0030199,GO:0031012,GO:0034097,GO:0035025,GO:0042060,GO:0043588,GO:0046872,GO:0048407,GO:0050776,GO:0050777,GO:0062023,GO:0097435,GO:2001223" skeletal system development|protease binding|integrin binding|extracellular matrix structural constituent|protein binding|extracellular region|collagen type III trimer|extracellular space|endoplasmic reticulum lumen|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|heart development|response to radiation|response to mechanical stimulus|peptide cross-linking|cerebral cortex development|extracellular matrix structural constituent conferring tensile strength|platelet activation|extracellular matrix organization|collagen fibril organization|extracellular matrix|response to cytokine|positive regulation of Rho protein signal transduction|wound healing|skin development|metal ion binding|platelet-derived growth factor binding|regulation of immune response|negative regulation of immune response|collagen-containing extracellular matrix|supramolecular fiber organization|negative regulation of neuron migration "hsa04611,hsa04926,hsa04933,hsa04974,hsa05146" Platelet activation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis COL4A1 1613.23391 2415.595205 810.8726148 0.335682325 -1.574831519 2.79E-06 0.000941516 7.844910254 2.746833808 1282 collagen type IV alpha 1 chain "GO:0001569,GO:0005201,GO:0005515,GO:0005576,GO:0005587,GO:0005604,GO:0005615,GO:0005788,GO:0007420,GO:0007528,GO:0030020,GO:0030198,GO:0030855,GO:0031012,GO:0038063,GO:0048407,GO:0048514,GO:0061304,GO:0061333,GO:0062023,GO:0071230,GO:0071711" branching involved in blood vessel morphogenesis|extracellular matrix structural constituent|protein binding|extracellular region|collagen type IV trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|brain development|neuromuscular junction development|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|epithelial cell differentiation|extracellular matrix|collagen-activated tyrosine kinase receptor signaling pathway|platelet-derived growth factor binding|blood vessel morphogenesis|retinal blood vessel morphogenesis|renal tubule morphogenesis|collagen-containing extracellular matrix|cellular response to amino acid stimulus|basement membrane organization "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A2 6363.963435 7823.280604 4904.646266 0.626929611 -0.673624623 0.039212767 0.908529654 61.46781938 40.19597051 1284 collagen type IV alpha 2 chain "GO:0001525,GO:0005201,GO:0005515,GO:0005576,GO:0005587,GO:0005615,GO:0005788,GO:0006351,GO:0007568,GO:0014823,GO:0016525,GO:0030020,GO:0030198,GO:0031012,GO:0035987,GO:0038063,GO:0062023,GO:0070062,GO:0071560" "angiogenesis|extracellular matrix structural constituent|protein binding|extracellular region|collagen type IV trimer|extracellular space|endoplasmic reticulum lumen|transcription, DNA-templated|aging|response to activity|negative regulation of angiogenesis|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|endodermal cell differentiation|collagen-activated tyrosine kinase receptor signaling pathway|collagen-containing extracellular matrix|extracellular exosome|cellular response to transforming growth factor beta stimulus" "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A3 7.537940883 10.14955968 4.926322083 0.485372985 -1.042834281 0.538494358 1 0.059702601 0.030226286 1285 collagen type IV alpha 3 chain "GO:0005178,GO:0005198,GO:0005201,GO:0005515,GO:0005576,GO:0005587,GO:0005604,GO:0005615,GO:0005783,GO:0005788,GO:0006919,GO:0007155,GO:0007166,GO:0007605,GO:0008015,GO:0008191,GO:0008285,GO:0009749,GO:0010951,GO:0016525,GO:0030020,GO:0030198,GO:0031012,GO:0032836,GO:0038063,GO:0043231,GO:0062023,GO:0072577,GO:1905563" integrin binding|structural molecule activity|extracellular matrix structural constituent|protein binding|extracellular region|collagen type IV trimer|basement membrane|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell adhesion|cell surface receptor signaling pathway|sensory perception of sound|blood circulation|metalloendopeptidase inhibitor activity|negative regulation of cell population proliferation|response to glucose|negative regulation of endopeptidase activity|negative regulation of angiogenesis|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|glomerular basement membrane development|collagen-activated tyrosine kinase receptor signaling pathway|intracellular membrane-bounded organelle|collagen-containing extracellular matrix|endothelial cell apoptotic process|negative regulation of vascular endothelial cell proliferation "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A4 68.36651331 59.88240213 76.85062449 1.28335908 0.359924888 0.649338307 1 0.245255735 0.328309378 1286 collagen type IV alpha 4 chain "GO:0005201,GO:0005576,GO:0005587,GO:0005604,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0031012,GO:0032836,GO:0062023" extracellular matrix structural constituent|extracellular region|collagen type IV trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|glomerular basement membrane development|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A5 1031.799236 1059.614031 1003.98444 0.947500138 -0.077801942 0.826595972 1 7.41239124 7.325774491 1287 collagen type IV alpha 5 chain "GO:0005201,GO:0005576,GO:0005587,GO:0005604,GO:0005615,GO:0005788,GO:0007528,GO:0030020,GO:0030198,GO:0031012,GO:0031594,GO:0038063,GO:0062023" extracellular matrix structural constituent|extracellular region|collagen type IV trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|neuromuscular junction development|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|neuromuscular junction|collagen-activated tyrosine kinase receptor signaling pathway|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A6 288.2032038 202.9911937 373.4152139 1.839563614 0.879363567 0.067214867 1 1.220126733 2.341184731 1288 collagen type IV alpha 6 chain "GO:0005201,GO:0005515,GO:0005576,GO:0005587,GO:0005615,GO:0005788,GO:0007155,GO:0030020,GO:0030198,GO:0031012,GO:0038063,GO:0062023" extracellular matrix structural constituent|protein binding|extracellular region|collagen type IV trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|collagen-activated tyrosine kinase receptor signaling pathway|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL5A2 7736.467204 8734.711064 6738.223345 0.771430594 -0.374391732 0.256627697 1 63.35132481 50.97632108 1290 collagen type V alpha 2 chain "GO:0001501,GO:0001503,GO:0005201,GO:0005576,GO:0005588,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0030199,GO:0031012,GO:0043588,GO:0046332,GO:0046872,GO:0048592,GO:0062023,GO:0071230,GO:1903225" skeletal system development|ossification|extracellular matrix structural constituent|extracellular region|collagen type V trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|collagen fibril organization|extracellular matrix|skin development|SMAD binding|metal ion binding|eye morphogenesis|collagen-containing extracellular matrix|cellular response to amino acid stimulus|negative regulation of endodermal cell differentiation hsa04974 Protein digestion and absorption COL6A1 24751.84224 32704.92617 16798.7583 0.513646116 -0.961153359 0.011258413 0.456875857 394.0968676 211.1460305 1291 collagen type VI alpha 1 chain "GO:0001649,GO:0005518,GO:0005576,GO:0005589,GO:0005615,GO:0005765,GO:0005788,GO:0007155,GO:0016020,GO:0030020,GO:0030198,GO:0032991,GO:0035987,GO:0042383,GO:0048407,GO:0062023,GO:0070062,GO:0071230" osteoblast differentiation|collagen binding|extracellular region|collagen type VI trimer|extracellular space|lysosomal membrane|endoplasmic reticulum lumen|cell adhesion|membrane|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|protein-containing complex|endodermal cell differentiation|sarcolemma|platelet-derived growth factor binding|collagen-containing extracellular matrix|extracellular exosome|cellular response to amino acid stimulus "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL6A2 35845.66748 44441.87699 27249.45797 0.613148225 -0.705692217 0.08050056 1 479.8175843 306.8722126 1292 collagen type VI alpha 2 chain "GO:0005515,GO:0005518,GO:0005576,GO:0005581,GO:0005615,GO:0005788,GO:0007155,GO:0009749,GO:0030020,GO:0030198,GO:0032991,GO:0042383,GO:0062023,GO:0070062,GO:1903561" protein binding|collagen binding|extracellular region|collagen trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|response to glucose|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|protein-containing complex|sarcolemma|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL6A3 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.022745106 0 1293 collagen type VI alpha 3 chain "GO:0004867,GO:0005576,GO:0005589,GO:0005615,GO:0005788,GO:0007155,GO:0007517,GO:0010951,GO:0030020,GO:0030198,GO:0031012,GO:0042383,GO:0062023,GO:0070062,GO:1903561" serine-type endopeptidase inhibitor activity|extracellular region|collagen type VI trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|muscle organ development|negative regulation of endopeptidase activity|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|sarcolemma|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL7A1 10171.38839 13641.00821 6701.768561 0.491295691 -1.025336508 0.002577453 0.165567736 73.96883763 37.90597565 1294 collagen type VII alpha 1 chain "GO:0000139,GO:0004867,GO:0005515,GO:0005576,GO:0005590,GO:0005604,GO:0005615,GO:0005788,GO:0006888,GO:0007155,GO:0008544,GO:0010951,GO:0030020,GO:0030134,GO:0030198,GO:0033116,GO:0035987,GO:0048208,GO:0062023" Golgi membrane|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|collagen type VII trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|endoplasmic reticulum to Golgi vesicle-mediated transport|cell adhesion|epidermis development|negative regulation of endopeptidase activity|extracellular matrix structural constituent conferring tensile strength|COPII-coated ER to Golgi transport vesicle|extracellular matrix organization|endoplasmic reticulum-Golgi intermediate compartment membrane|endodermal cell differentiation|COPII vesicle coating|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL8A1 10391.80281 9613.662932 11169.94269 1.161882081 0.216463657 0.521451452 1 87.30466426 105.8072508 1295 collagen type VIII alpha 1 chain "GO:0001525,GO:0005201,GO:0005515,GO:0005576,GO:0005591,GO:0005615,GO:0005788,GO:0007155,GO:0010811,GO:0030020,GO:0030198,GO:0031012,GO:0035987,GO:0048593,GO:0050673,GO:0062023" angiogenesis|extracellular matrix structural constituent|protein binding|extracellular region|collagen type VIII trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|positive regulation of cell-substrate adhesion|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|endodermal cell differentiation|camera-type eye morphogenesis|epithelial cell proliferation|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL8A2 35.54102627 38.5683268 32.51372575 0.843016238 -0.246367675 0.817715771 1 0.361932498 0.318258088 1296 collagen type VIII alpha 2 chain "GO:0001525,GO:0005201,GO:0005576,GO:0005581,GO:0005604,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0030674,GO:0031012,GO:0048593,GO:0050673,GO:0062023,GO:0098609" angiogenesis|extracellular matrix structural constituent|extracellular region|collagen trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|protein-macromolecule adaptor activity|extracellular matrix|camera-type eye morphogenesis|epithelial cell proliferation|collagen-containing extracellular matrix|cell-cell adhesion hsa04974 Protein digestion and absorption COL9A2 51.05015714 54.80762229 47.29269199 0.862885307 -0.212759283 0.819830457 1 0.703271528 0.632982989 1298 collagen type IX alpha 2 chain "GO:0001501,GO:0005201,GO:0005515,GO:0005576,GO:0005594,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0031012,GO:0062023" skeletal system development|extracellular matrix structural constituent|protein binding|extracellular region|collagen type IX trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL9A3 243.8784292 237.4996966 250.2571618 1.053715712 0.075485686 0.889035263 1 4.478228512 4.922045637 1299 collagen type IX alpha 3 chain "GO:0005201,GO:0005576,GO:0005594,GO:0005604,GO:0005615,GO:0005788,GO:0008584,GO:0008585,GO:0030020,GO:0030198,GO:0031012,GO:0062023" extracellular matrix structural constituent|extracellular region|collagen type IX trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|male gonad development|female gonad development|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COLEC10 141.3933625 269.9782876 12.80843742 0.047442472 -4.397676999 1.52E-09 1.32E-06 3.859285306 0.190980985 10584 collectin subfamily member 10 "GO:0001867,GO:0005537,GO:0005576,GO:0005581,GO:0005615,GO:0005737,GO:0005794,GO:0006956,GO:0042056,GO:0050918,GO:1904888" "complement activation, lectin pathway|mannose binding|extracellular region|collagen trimer|extracellular space|cytoplasm|Golgi apparatus|complement activation|chemoattractant activity|positive chemotaxis|cranial skeletal system development" COLGALT1 5176.55378 5824.832302 4528.275258 0.777408691 -0.363254858 0.259009858 1 74.98912236 60.80840224 79709 collagen beta(1-O)galactosyltransferase 1 "GO:0005788,GO:0016020,GO:0018215,GO:0050211,GO:1904028" endoplasmic reticulum lumen|membrane|protein phosphopantetheinylation|procollagen galactosyltransferase activity|positive regulation of collagen fibril organization "hsa00310,hsa00514" Lysine degradation|Other types of O-glycan biosynthesis COLGALT2 56.28824052 76.12169763 36.45478341 0.478901345 -1.062199606 0.195411818 1 0.663904847 0.331640702 23127 collagen beta(1-O)galactosyltransferase 2 "GO:0005515,GO:0005788,GO:0018215,GO:0050211" protein binding|endoplasmic reticulum lumen|protein phosphopantetheinylation|procollagen galactosyltransferase activity "hsa00310,hsa00514" Lysine degradation|Other types of O-glycan biosynthesis COLQ 9.463932389 7.104691779 11.823173 1.664135949 0.734773297 0.648013687 1 0.108349164 0.188074666 8292 collagen like tail subunit of asymmetric acetylcholinesterase "GO:0001507,GO:0005201,GO:0005515,GO:0005581,GO:0005604,GO:0005615,GO:0005886,GO:0008201,GO:0030054,GO:0030198,GO:0031012,GO:0043083,GO:0062023" acetylcholine catabolic process in synaptic cleft|extracellular matrix structural constituent|protein binding|collagen trimer|basement membrane|extracellular space|plasma membrane|heparin binding|cell junction|extracellular matrix organization|extracellular matrix|synaptic cleft|collagen-containing extracellular matrix COMMD1 180.4530837 178.6322504 182.2739171 1.020386389 0.029115561 0.969276391 1 2.999699373 3.19270152 150684 copper metabolism domain containing 1 "GO:0005507,GO:0005515,GO:0005546,GO:0005547,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0006289,GO:0006893,GO:0010008,GO:0015031,GO:0016567,GO:0019871,GO:0031398,GO:0031462,GO:0032088,GO:0032434,GO:0042802,GO:0042803,GO:0043325,GO:0043687,GO:0048227,GO:0055037,GO:0055070,GO:0070300,GO:0080025,GO:1902306,GO:2000009" "copper ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytoplasm|endosome|early endosome|cytosol|nucleotide-excision repair|Golgi to plasma membrane transport|endosome membrane|protein transport|protein ubiquitination|sodium channel inhibitor activity|positive regulation of protein ubiquitination|Cul2-RING ubiquitin ligase complex|negative regulation of NF-kappaB transcription factor activity|regulation of proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|protein homodimerization activity|phosphatidylinositol-3,4-bisphosphate binding|post-translational protein modification|plasma membrane to endosome transport|recycling endosome|copper ion homeostasis|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|negative regulation of sodium ion transmembrane transport|negative regulation of protein localization to cell surface" COMMD10 332.7155302 248.6642123 416.7668482 1.676022635 0.745041633 0.104336785 1 7.970863997 13.93481503 51397 COMM domain containing 10 "GO:0005515,GO:0005654,GO:0005737" protein binding|nucleoplasm|cytoplasm COMMD2 391.699021 408.0122993 375.3857427 0.92003536 -0.120238785 0.787338117 1 5.594039951 5.368414151 51122 COMM domain containing 2 "GO:0005515,GO:0005737" protein binding|cytoplasm COMMD3 66.97769134 65.97213794 67.98324474 1.030484184 0.043322362 0.976788525 1 3.608267874 3.878430665 23412 COMM domain containing 3 "GO:0005515,GO:0005576,GO:0005634,GO:0006814,GO:0043312,GO:1904813" protein binding|extracellular region|nucleus|sodium ion transport|neutrophil degranulation|ficolin-1-rich granule lumen COMMD4 2300.912346 1941.610767 2660.213925 1.370106702 0.454288252 0.1557978 1 92.68212609 132.4543751 54939 COMM domain containing 4 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0043231" protein binding|nucleus|cytoplasm|cytosol|plasma membrane|intracellular membrane-bounded organelle COMMD5 666.2070002 685.0952787 647.3187217 0.944859411 -0.081828413 0.833614567 1 20.07966377 19.78971589 28991 COMM domain containing 5 "GO:0005515,GO:0005634,GO:0005654,GO:0005829" protein binding|nucleus|nucleoplasm|cytosol COMMD6 550.493855 554.1659587 546.8217512 0.986747278 -0.019247461 0.966502687 1 13.99827972 14.40776227 170622 COMM domain containing 6 "GO:0005515,GO:0005634,GO:0005737,GO:0032088,GO:0051059" protein binding|nucleus|cytoplasm|negative regulation of NF-kappaB transcription factor activity|NF-kappaB binding COMMD7 1167.278536 992.6269371 1341.930135 1.351897763 0.434986052 0.205600593 1 27.59223523 38.90869482 149951 COMM domain containing 7 "GO:0005515,GO:0031410,GO:0032088,GO:0033209,GO:0045892,GO:0051059" "protein binding|cytoplasmic vesicle|negative regulation of NF-kappaB transcription factor activity|tumor necrosis factor-mediated signaling pathway|negative regulation of transcription, DNA-templated|NF-kappaB binding" COMMD8 151.8682915 144.1237475 159.6128355 1.107470755 0.147268602 0.812021604 1 2.557589129 2.954465845 54951 COMM domain containing 8 "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol COMMD9 932.1944956 918.5351514 945.8538399 1.029741582 0.042282332 0.908621484 1 15.62141203 16.77893793 29099 COMM domain containing 9 "GO:0005515,GO:0005576,GO:0005654,GO:0005794,GO:0005829,GO:0006814,GO:0034774,GO:0042632,GO:0043312,GO:1904813" protein binding|extracellular region|nucleoplasm|Golgi apparatus|cytosol|sodium ion transport|secretory granule lumen|cholesterol homeostasis|neutrophil degranulation|ficolin-1-rich granule lumen COMT 933.927246 1272.754784 595.0997076 0.467568235 -1.096751175 0.002310361 0.153503118 22.58603357 11.01541587 1312 catechol-O-methyltransferase "GO:0000287,GO:0005515,GO:0005829,GO:0005886,GO:0008168,GO:0008171,GO:0016020,GO:0016021,GO:0016206,GO:0030424,GO:0030425,GO:0032259,GO:0032502,GO:0042135,GO:0042417,GO:0042424,GO:0043231,GO:0070062,GO:0102084,GO:0102938" magnesium ion binding|protein binding|cytosol|plasma membrane|methyltransferase activity|O-methyltransferase activity|membrane|integral component of membrane|catechol O-methyltransferase activity|axon|dendrite|methylation|developmental process|neurotransmitter catabolic process|dopamine metabolic process|catecholamine catabolic process|intracellular membrane-bounded organelle|extracellular exosome|L-dopa O-methyltransferase activity|orcinol O-methyltransferase activity "hsa00140,hsa00350,hsa04728" Steroid hormone biosynthesis|Tyrosine metabolism|Dopaminergic synapse COMTD1 296.0744327 336.9653815 255.1834839 0.757298814 -0.401065425 0.399405536 1 12.92886957 10.21277492 118881 catechol-O-methyltransferase domain containing 1 "GO:0005515,GO:0008171,GO:0008757,GO:0016021,GO:0032259" protein binding|O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|integral component of membrane|methylation COP1 868.4276973 836.3237179 900.5316767 1.07677405 0.106715547 0.770147023 1 4.558911413 5.120373763 64326 COP1 E3 ubiquitin ligase "GO:0000139,GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0010212,GO:0016567,GO:0016607,GO:0031464,GO:0032436,GO:0043161,GO:0043687,GO:0046872,GO:0061630" Golgi membrane|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|response to ionizing radiation|protein ubiquitination|nuclear speck|Cul4A-RING E3 ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|metal ion binding|ubiquitin protein ligase activity "hsa04115,hsa04120" p53 signaling pathway|Ubiquitin mediated proteolysis COPA 7486.091768 7985.673559 6986.509978 0.874880488 -0.192842143 0.557882554 1 75.66813733 69.05222925 1314 COPI coat complex subunit alpha "GO:0000139,GO:0005179,GO:0005198,GO:0005515,GO:0005615,GO:0005737,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0007165,GO:0016020,GO:0030126,GO:0030133,GO:0030157,GO:0030426,GO:0070062" "Golgi membrane|hormone activity|structural molecule activity|protein binding|extracellular space|cytoplasm|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|signal transduction|membrane|COPI vesicle coat|transport vesicle|pancreatic juice secretion|growth cone|extracellular exosome" COPB1 4832.803879 4687.066662 4978.541097 1.062186962 0.087037726 0.78642922 1 69.12737084 76.58909456 1315 COPI coat complex subunit beta 1 "GO:0000139,GO:0005198,GO:0005515,GO:0005789,GO:0005793,GO:0005794,GO:0005798,GO:0005829,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0016020,GO:0016032,GO:0030126,GO:0030133,GO:0030667,GO:0043231,GO:0043312,GO:0070821,GO:0101003" "Golgi membrane|structural molecule activity|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|Golgi-associated vesicle|cytosol|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|membrane|viral process|COPI vesicle coat|transport vesicle|secretory granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|tertiary granule membrane|ficolin-1-rich granule membrane" COPB2 3604.894963 3961.373145 3248.416781 0.820022922 -0.286263857 0.368451246 1 39.27752053 33.5958773 9276 COPI coat complex subunit beta 2 "GO:0000139,GO:0005198,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0030126,GO:0030133,GO:1901998" "Golgi membrane|structural molecule activity|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|COPI vesicle coat|transport vesicle|toxin transport" COPE 2236.762033 2169.97586 2303.548206 1.061554761 0.086178796 0.788793698 1 91.58468509 101.4100948 11316 COPI coat complex subunit epsilon "GO:0000139,GO:0005198,GO:0005515,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0006890,GO:0006891,GO:0015031,GO:0030126,GO:0030133" "Golgi membrane|structural molecule activity|protein binding|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|protein transport|COPI vesicle coat|transport vesicle" COPG1 3758.104817 4129.855835 3386.3538 0.81996901 -0.28635871 0.368536293 1 64.25887214 54.95996748 22820 COPI coat complex subunit gamma 1 "GO:0000139,GO:0005198,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0009306,GO:0030126,GO:0030133,GO:0051683,GO:0072384" "Golgi membrane|structural molecule activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|protein secretion|COPI vesicle coat|transport vesicle|establishment of Golgi localization|organelle transport along microtubule" COPG2 1145.479747 1219.977074 1070.982421 0.87787094 -0.187919237 0.586389366 1 15.36621114 14.07062533 26958 COPI coat complex subunit gamma 2 "GO:0000139,GO:0005198,GO:0005783,GO:0005789,GO:0005793,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0009306,GO:0030126,GO:0030133,GO:0030426,GO:0072384" "Golgi membrane|structural molecule activity|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|protein secretion|COPI vesicle coat|transport vesicle|growth cone|organelle transport along microtubule" COPRS 772.0432529 747.0075927 797.078913 1.067029199 0.093599655 0.803047469 1 35.2593656 39.24340908 55352 coordinator of PRMT5 and differentiation stimulator "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0007517,GO:0042393,GO:0043985" protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|muscle organ development|histone binding|histone H4-R3 methylation COPS2 1078.04728 1055.554207 1100.540353 1.042618509 0.060211376 0.864997938 1 8.103698169 8.813017184 9318 COP9 signalosome subunit 2 "GO:0000122,GO:0000338,GO:0000715,GO:0001833,GO:0003714,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006283,GO:0006366,GO:0006468,GO:0007165,GO:0008180,GO:0030182,GO:0035914,GO:0043687,GO:0045892,GO:1903507" "negative regulation of transcription by RNA polymerase II|protein deneddylation|nucleotide-excision repair, DNA damage recognition|inner cell mass cell proliferation|transcription corepressor activity|protein binding|nucleoplasm|cytoplasm|cytosol|transcription-coupled nucleotide-excision repair|transcription by RNA polymerase II|protein phosphorylation|signal transduction|COP9 signalosome|neuron differentiation|skeletal muscle cell differentiation|post-translational protein modification|negative regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription" COPS3 2003.888775 2078.629823 1929.147728 0.928086235 -0.107669232 0.739198974 1 54.12610158 52.39755349 8533 COP9 signalosome subunit 3 "GO:0000338,GO:0000715,GO:0001701,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006283,GO:0006511,GO:0007165,GO:0008180,GO:0009416,GO:0043687" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|in utero embryonic development|protein binding|nucleoplasm|cytoplasm|cytosol|transcription-coupled nucleotide-excision repair|ubiquitin-dependent protein catabolic process|signal transduction|COP9 signalosome|response to light stimulus|post-translational protein modification" COPS4 523.3572678 517.6275439 529.0869917 1.022138404 0.03159056 0.942645169 1 14.57254531 15.53678122 51138 COP9 signalosome subunit 4 "GO:0000338,GO:0000715,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006283,GO:0008021,GO:0008180,GO:0016607,GO:0019784,GO:0030054,GO:0043687" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|protein binding|nucleus|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|synaptic vesicle|COP9 signalosome|nuclear speck|NEDD8-specific protease activity|cell junction|post-translational protein modification" COPS5 1735.20603 1761.963561 1708.448498 0.9696276 -0.04449733 0.893136907 1 68.85589393 69.64052227 10987 COP9 signalosome subunit 5 "GO:0000338,GO:0000715,GO:0000785,GO:0003713,GO:0003743,GO:0004222,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005852,GO:0006283,GO:0006412,GO:0006413,GO:0008021,GO:0008180,GO:0008237,GO:0016579,GO:0018215,GO:0019784,GO:0019899,GO:0035718,GO:0043066,GO:0043687,GO:0045944,GO:0046328,GO:0046872,GO:0048471,GO:0051091,GO:0051726,GO:0070122,GO:1903894,GO:1990182" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|chromatin|transcription coactivator activity|translation initiation factor activity|metalloendopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|transcription-coupled nucleotide-excision repair|translation|translational initiation|synaptic vesicle|COP9 signalosome|metallopeptidase activity|protein deubiquitination|protein phosphopantetheinylation|NEDD8-specific protease activity|enzyme binding|macrophage migration inhibitory factor binding|negative regulation of apoptotic process|post-translational protein modification|positive regulation of transcription by RNA polymerase II|regulation of JNK cascade|metal ion binding|perinuclear region of cytoplasm|positive regulation of DNA-binding transcription factor activity|regulation of cell cycle|isopeptidase activity|regulation of IRE1-mediated unfolded protein response|exosomal secretion" COPS6 2613.979003 2598.287279 2629.670728 1.012078514 0.017321214 0.957937565 1 93.7279804 98.94626242 10980 COP9 signalosome subunit 6 "GO:0000338,GO:0000715,GO:0005515,GO:0005654,GO:0005829,GO:0006283,GO:0008180,GO:0008237,GO:0016032,GO:0043687,GO:0048471,GO:0070122" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|protein binding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|COP9 signalosome|metallopeptidase activity|viral process|post-translational protein modification|perinuclear region of cytoplasm|isopeptidase activity" COPS7A 1198.661015 1319.442759 1077.879272 0.816920071 -0.291733166 0.394057201 1 31.32917066 26.6958894 50813 COP9 signalosome subunit 7A "GO:0000338,GO:0000715,GO:0005515,GO:0005654,GO:0005829,GO:0006283,GO:0008180,GO:0010387,GO:0016032,GO:0043687" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|protein binding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|COP9 signalosome|COP9 signalosome assembly|viral process|post-translational protein modification" COPS7B 599.982484 535.8967513 664.0682168 1.23917194 0.309376381 0.429526989 1 8.829303814 11.41232054 64708 COP9 signalosome subunit 7B "GO:0000338,GO:0000715,GO:0005515,GO:0005654,GO:0005829,GO:0006283,GO:0008180,GO:0010387,GO:0016032,GO:0043687" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|protein binding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|COP9 signalosome|COP9 signalosome assembly|viral process|post-translational protein modification" COPS8 702.3621465 698.2897062 706.4345867 1.011664042 0.016730273 0.968780471 1 10.09589215 10.65361372 10920 COP9 signalosome subunit 8 "GO:0000338,GO:0000715,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006283,GO:0006468,GO:0007250,GO:0008180,GO:0008285,GO:0010387,GO:0043687,GO:0048471,GO:0070062" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|protein binding|nucleus|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|protein phosphorylation|activation of NF-kappaB-inducing kinase activity|COP9 signalosome|negative regulation of cell population proliferation|COP9 signalosome assembly|post-translational protein modification|perinuclear region of cytoplasm|extracellular exosome" COPS9 224.0098373 226.3351809 221.6844937 0.979452212 -0.02995299 0.963374992 1 11.45162683 11.69947486 150678 COP9 signalosome subunit 9 "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008180,GO:0008284,GO:0034644,GO:2000435" chromatin|protein binding|nucleus|nucleoplasm|cytoplasm|COP9 signalosome|positive regulation of cell population proliferation|cellular response to UV|negative regulation of protein neddylation COPZ1 3663.468461 3654.856442 3672.08048 1.004712644 0.006782938 0.983952945 1 93.77182636 98.27208543 22818 COPI coat complex subunit zeta 1 "GO:0000139,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0030126,GO:0030133" "Golgi membrane|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|COPI vesicle coat|transport vesicle" COPZ2 228.3396068 219.2304892 237.4487244 1.083100828 0.115167553 0.830712039 1 12.14797689 13.72425487 51226 COPI coat complex subunit zeta 2 "GO:0000139,GO:0005789,GO:0005801,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0030126,GO:0030133,GO:0033116" "Golgi membrane|endoplasmic reticulum membrane|cis-Golgi network|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|COPI vesicle coat|transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane" COQ10A 306.707222 289.262451 324.151993 1.120615524 0.164291383 0.731106367 1 8.730704819 10.2052082 93058 coenzyme Q10A "GO:0005739,GO:0005743,GO:0006744,GO:0045333,GO:0048039" mitochondrion|mitochondrial inner membrane|ubiquinone biosynthetic process|cellular respiration|ubiquinone binding COQ10B 498.7607921 452.6703619 544.8512224 1.203637941 0.267401489 0.514570639 1 10.62872365 13.34421142 80219 coenzyme Q10B "GO:0005739,GO:0005743,GO:0006744,GO:0045333,GO:0048039" mitochondrion|mitochondrial inner membrane|ubiquinone biosynthetic process|cellular respiration|ubiquinone binding COQ2 478.8949219 408.0122993 549.7775444 1.347453362 0.430235339 0.298036523 1 13.55041546 19.04505728 27235 "coenzyme Q2, polyprenyltransferase" "GO:0002083,GO:0004659,GO:0005743,GO:0006071,GO:0006744,GO:0008299,GO:0016765,GO:0031305,GO:0047293" "4-hydroxybenzoate decaprenyltransferase activity|prenyltransferase activity|mitochondrial inner membrane|glycerol metabolic process|ubiquinone biosynthetic process|isoprenoid biosynthetic process|transferase activity, transferring alkyl or aryl (other than methyl) groups|integral component of mitochondrial inner membrane|4-hydroxybenzoate nonaprenyltransferase activity" hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ3 162.6144038 171.5275587 153.701249 0.896073204 -0.158311499 0.792029847 1 5.622825717 5.255500025 51805 "coenzyme Q3, methyltransferase" "GO:0004395,GO:0005515,GO:0005739,GO:0005759,GO:0006071,GO:0006744,GO:0008171,GO:0008425,GO:0008689,GO:0010795,GO:0031314,GO:0032259,GO:0044595,GO:0044596" "hexaprenyldihydroxybenzoate methyltransferase activity|protein binding|mitochondrion|mitochondrial matrix|glycerol metabolic process|ubiquinone biosynthetic process|O-methyltransferase activity|2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|regulation of ubiquinone biosynthetic process|extrinsic component of mitochondrial inner membrane|methylation|decaprenyldihydroxybenzoate methyltransferase activity|3-demethylubiquinol-10 3-O-methyltransferase activity" hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ4 784.1066799 729.7533413 838.4600185 1.14896359 0.20033308 0.588408724 1 20.70556432 24.81471362 51117 coenzyme Q4 "GO:0005515,GO:0005739,GO:0006744,GO:0031314,GO:0032991" protein binding|mitochondrion|ubiquinone biosynthetic process|extrinsic component of mitochondrial inner membrane|protein-containing complex COQ5 550.4790092 553.1510028 547.8070156 0.990339008 -0.014005628 0.97705987 1 14.72930962 15.21535911 84274 "coenzyme Q5, methyltransferase" "GO:0005515,GO:0005743,GO:0005759,GO:0006744,GO:0008168,GO:0031314,GO:0032259,GO:0032991,GO:0043333,GO:0043430" "protein binding|mitochondrial inner membrane|mitochondrial matrix|ubiquinone biosynthetic process|methyltransferase activity|extrinsic component of mitochondrial inner membrane|methylation|protein-containing complex|2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity|2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ6 374.9670933 375.5337083 374.4004783 0.996982348 -0.004360133 0.999064501 1 7.062553851 7.34454965 51004 "coenzyme Q6, monooxygenase" "GO:0005515,GO:0005739,GO:0005794,GO:0006744,GO:0016491,GO:0016709,GO:0016712,GO:0031314,GO:0042995,GO:0055114,GO:0071949" "protein binding|mitochondrion|Golgi apparatus|ubiquinone biosynthetic process|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|extrinsic component of mitochondrial inner membrane|cell projection|oxidation-reduction process|FAD binding" hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ7 265.6878583 246.6343003 284.7414164 1.154508582 0.207278898 0.67765767 1 3.844615955 4.629840816 10229 "coenzyme Q7, hydroxylase" "GO:0005515,GO:0005634,GO:0005743,GO:0006744,GO:0008340,GO:0008682,GO:0010468,GO:0016709,GO:0031314,GO:0046872,GO:0055114,GO:2000377" "protein binding|nucleus|mitochondrial inner membrane|ubiquinone biosynthetic process|determination of adult lifespan|2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity|regulation of gene expression|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|extrinsic component of mitochondrial inner membrane|metal ion binding|oxidation-reduction process|regulation of reactive oxygen species metabolic process" hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ8A 330.3832596 291.2923629 369.4741562 1.268396303 0.343005577 0.45630561 1 4.17102928 5.518412183 56997 coenzyme Q8A "GO:0004672,GO:0005515,GO:0005524,GO:0005739,GO:0006468,GO:0006744,GO:0016021,GO:0016301,GO:0016310,GO:0031314,GO:0043531" protein kinase activity|protein binding|ATP binding|mitochondrion|protein phosphorylation|ubiquinone biosynthetic process|integral component of membrane|kinase activity|phosphorylation|extrinsic component of mitochondrial inner membrane|ADP binding COQ8B 259.8180876 283.1727152 236.46346 0.835050297 -0.260064997 0.60281183 1 5.713824323 4.976860275 79934 coenzyme Q8B "GO:0004672,GO:0005524,GO:0005739,GO:0005829,GO:0005886,GO:0006468,GO:0006744,GO:0008289,GO:0016021,GO:0016301,GO:0016887,GO:0021692,GO:0031314" protein kinase activity|ATP binding|mitochondrion|cytosol|plasma membrane|protein phosphorylation|ubiquinone biosynthetic process|lipid binding|integral component of membrane|kinase activity|ATPase activity|cerebellar Purkinje cell layer morphogenesis|extrinsic component of mitochondrial inner membrane COQ9 667.1328815 681.0354548 653.2303082 0.959172248 -0.060138177 0.878452598 1 21.16076272 21.17112088 57017 coenzyme Q9 "GO:0005515,GO:0005739,GO:0005743,GO:0006120,GO:0006744,GO:0008289,GO:0042803" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial electron transport, NADH to ubiquinone|ubiquinone biosynthetic process|lipid binding|protein homodimerization activity" CORO1A 197.5737232 204.0061496 191.1412968 0.936938897 -0.09397313 0.870770436 1 5.077244122 4.961982683 11151 coronin 1A "GO:0001771,GO:0001772,GO:0001845,GO:0001891,GO:0003723,GO:0003779,GO:0003785,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005884,GO:0005886,GO:0005911,GO:0006816,GO:0006909,GO:0007015,GO:0008022,GO:0008092,GO:0008360,GO:0016020,GO:0016477,GO:0030027,GO:0030036,GO:0030335,GO:0030424,GO:0030595,GO:0030670,GO:0030864,GO:0031339,GO:0031589,GO:0032036,GO:0032796,GO:0032956,GO:0032991,GO:0038180,GO:0042102,GO:0042803,GO:0043029,GO:0043320,GO:0043524,GO:0043548,GO:0045087,GO:0045335,GO:0048873,GO:0050918,GO:0051015,GO:0051126,GO:0051279,GO:0061502,GO:0070062,GO:0071353,GO:0098978" immunological synapse formation|immunological synapse|phagolysosome assembly|phagocytic cup|RNA binding|actin binding|actin monomer binding|protein binding|nucleus|cytoplasm|early endosome|cytosol|actin filament|plasma membrane|cell-cell junction|calcium ion transport|phagocytosis|actin filament organization|protein C-terminus binding|cytoskeletal protein binding|regulation of cell shape|membrane|cell migration|lamellipodium|actin cytoskeleton organization|positive regulation of cell migration|axon|leukocyte chemotaxis|phagocytic vesicle membrane|cortical actin cytoskeleton|negative regulation of vesicle fusion|cell-substrate adhesion|myosin heavy chain binding|uropod organization|regulation of actin cytoskeleton organization|protein-containing complex|nerve growth factor signaling pathway|positive regulation of T cell proliferation|protein homodimerization activity|T cell homeostasis|natural killer cell degranulation|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|innate immune response|phagocytic vesicle|homeostasis of number of cells within a tissue|positive chemotaxis|actin filament binding|negative regulation of actin nucleation|regulation of release of sequestered calcium ion into cytosol|early endosome to recycling endosome transport|extracellular exosome|cellular response to interleukin-4|glutamatergic synapse "hsa04145,hsa05152" Phagosome|Tuberculosis CORO1B 2621.701775 2722.111907 2521.291642 0.926226301 -0.110563371 0.729349076 1 30.85616944 29.81089736 57175 coronin 1B "GO:0001725,GO:0005515,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005925,GO:0007015,GO:0016477,GO:0030027,GO:0030036,GO:0031252,GO:0031529,GO:0034315,GO:0034316,GO:0035767,GO:0036120,GO:0042060,GO:0042802,GO:0045296,GO:0048471,GO:0051015,GO:0051017,GO:0070062,GO:0071672,GO:0071933,GO:0071944,GO:0090135,GO:1902463,GO:2000394" stress fiber|protein binding|cytoplasm|cytosol|actin filament|plasma membrane|focal adhesion|actin filament organization|cell migration|lamellipodium|actin cytoskeleton organization|cell leading edge|ruffle organization|regulation of Arp2/3 complex-mediated actin nucleation|negative regulation of Arp2/3 complex-mediated actin nucleation|endothelial cell chemotaxis|cellular response to platelet-derived growth factor stimulus|wound healing|identical protein binding|cadherin binding|perinuclear region of cytoplasm|actin filament binding|actin filament bundle assembly|extracellular exosome|negative regulation of smooth muscle cell chemotaxis|Arp2/3 complex binding|cell periphery|actin filament branching|protein localization to cell leading edge|positive regulation of lamellipodium morphogenesis CORO1C 6053.318369 6759.606749 5347.029989 0.791026784 -0.33820155 0.29758387 1 66.70893129 55.04160657 23603 coronin 1C "GO:0001755,GO:0001932,GO:0001933,GO:0005515,GO:0005925,GO:0005938,GO:0006909,GO:0007015,GO:0007165,GO:0010008,GO:0010632,GO:0010633,GO:0010762,GO:0015629,GO:0016197,GO:0016328,GO:0016477,GO:0016600,GO:0030017,GO:0030027,GO:0031267,GO:0031982,GO:0032587,GO:0042383,GO:0044387,GO:0045184,GO:0045202,GO:0051015,GO:0051893,GO:0051895,GO:0090148,GO:0090630,GO:0097750,GO:0140285,GO:1900024,GO:1900025,GO:1900027,GO:2000394" neural crest cell migration|regulation of protein phosphorylation|negative regulation of protein phosphorylation|protein binding|focal adhesion|cell cortex|phagocytosis|actin filament organization|signal transduction|endosome membrane|regulation of epithelial cell migration|negative regulation of epithelial cell migration|regulation of fibroblast migration|actin cytoskeleton|endosomal transport|lateral plasma membrane|cell migration|flotillin complex|sarcomere|lamellipodium|small GTPase binding|vesicle|ruffle membrane|sarcolemma|negative regulation of protein kinase activity by regulation of protein phosphorylation|establishment of protein localization|synapse|actin filament binding|regulation of focal adhesion assembly|negative regulation of focal adhesion assembly|membrane fission|activation of GTPase activity|endosome membrane tubulation|endosome fission|regulation of substrate adhesion-dependent cell spreading|negative regulation of substrate adhesion-dependent cell spreading|regulation of ruffle assembly|positive regulation of lamellipodium morphogenesis CORO2A 1343.156153 1262.605225 1423.707082 1.127594797 0.173248726 0.607435707 1 10.37250615 12.19979952 7464 coronin 2A "GO:0005515,GO:0017053,GO:0035556,GO:0051015" protein binding|transcription repressor complex|intracellular signal transduction|actin filament binding CORO2B 208.2268015 90.33108119 326.1225219 3.61030243 1.852119695 0.000727507 0.076438948 1.072924623 4.040440593 10391 coronin 2B "GO:0003093,GO:0003779,GO:0005515,GO:0005737,GO:0005925,GO:0010812,GO:0015629,GO:0016020,GO:0017166,GO:0030036,GO:0032956,GO:0048041,GO:0051015,GO:0051497,GO:0080135,GO:1904950,GO:1904951,GO:1990147" regulation of glomerular filtration|actin binding|protein binding|cytoplasm|focal adhesion|negative regulation of cell-substrate adhesion|actin cytoskeleton|membrane|vinculin binding|actin cytoskeleton organization|regulation of actin cytoskeleton organization|focal adhesion assembly|actin filament binding|negative regulation of stress fiber assembly|regulation of cellular response to stress|negative regulation of establishment of protein localization|positive regulation of establishment of protein localization|talin binding CORO6 66.12603891 75.10674166 57.14533616 0.76085495 -0.394306652 0.620658264 1 0.890841102 0.706997774 84940 coronin 6 "GO:0005515,GO:0007015,GO:0016477,GO:0051015" protein binding|actin filament organization|cell migration|actin filament binding CORO7 70.7405997 53.79266632 87.68853307 1.630120592 0.704978695 0.355959126 1 0.745392279 1.267419992 79585 coronin 7 "GO:0000139,GO:0003779,GO:0005515,GO:0005794,GO:0005802,GO:0005829,GO:0006895,GO:0007015,GO:0015031,GO:0016020,GO:0016021,GO:0030041,GO:0031410,GO:0051015" Golgi membrane|actin binding|protein binding|Golgi apparatus|trans-Golgi network|cytosol|Golgi to endosome transport|actin filament organization|protein transport|membrane|integral component of membrane|actin filament polymerization|cytoplasmic vesicle|actin filament binding COTL1 2941.039039 3369.653815 2512.424262 0.74560308 -0.423520276 0.183502401 1 92.64987964 72.05572337 23406 coactosin like F-actin binding protein 1 "GO:0003779,GO:0005515,GO:0005576,GO:0005634,GO:0005829,GO:0005884,GO:0005886,GO:0008150,GO:0019899,GO:0030833,GO:0030864,GO:0034774,GO:0043312,GO:0050832,GO:0051015,GO:0070062,GO:1904813" actin binding|protein binding|extracellular region|nucleus|cytosol|actin filament|plasma membrane|biological_process|enzyme binding|regulation of actin filament polymerization|cortical actin cytoskeleton|secretory granule lumen|neutrophil degranulation|defense response to fungus|actin filament binding|extracellular exosome|ficolin-1-rich granule lumen COX10 284.1973198 265.9184637 302.4761759 1.137477149 0.185837563 0.703811444 1 4.647285053 5.51388777 1352 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 "GO:0000266,GO:0004129,GO:0004311,GO:0005730,GO:0005739,GO:0005743,GO:0005829,GO:0006123,GO:0006783,GO:0006784,GO:0008495,GO:0008535,GO:0016021,GO:0045333,GO:0048034,GO:0070069,GO:1902600" "mitochondrial fission|cytochrome-c oxidase activity|farnesyltranstransferase activity|nucleolus|mitochondrion|mitochondrial inner membrane|cytosol|mitochondrial electron transport, cytochrome c to oxygen|heme biosynthetic process|heme A biosynthetic process|protoheme IX farnesyltransferase activity|respiratory chain complex IV assembly|integral component of membrane|cellular respiration|heme O biosynthetic process|cytochrome complex|proton transmembrane transport" "hsa00190,hsa00860,hsa04714" Oxidative phosphorylation|Porphyrin and chlorophyll metabolism|Thermogenesis COX11 1246.908042 1148.930156 1344.885929 1.170554991 0.227192712 0.504642903 1 5.177440985 6.321540258 1353 cytochrome c oxidase copper chaperone COX11 "GO:0005507,GO:0005515,GO:0005739,GO:0009055,GO:0022900,GO:0031304,GO:0031305,GO:0032991,GO:0033132,GO:0055065" copper ion binding|protein binding|mitochondrion|electron transfer activity|electron transport chain|intrinsic component of mitochondrial inner membrane|integral component of mitochondrial inner membrane|protein-containing complex|negative regulation of glucokinase activity|metal ion homeostasis "hsa00190,hsa04714" Oxidative phosphorylation|Thermogenesis COX14 501.5950976 478.0442611 525.145934 1.098529941 0.135574192 0.743189594 1 44.50598417 50.99718889 84987 cytochrome c oxidase assembly factor COX14 "GO:0005515,GO:0005739,GO:0016021,GO:0031966,GO:0033617" protein binding|mitochondrion|integral component of membrane|mitochondrial membrane|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COX15 2493.860376 2671.364109 2316.356643 0.867106298 -0.205719231 0.51935653 1 18.57684582 16.80197163 1355 cytochrome c oxidase assembly homolog COX15 "GO:0004129,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005746,GO:0006123,GO:0006783,GO:0006784,GO:0007585,GO:0008535,GO:0016021,GO:0016627,GO:0016653,GO:0020037,GO:0045333,GO:0055114,GO:0060090,GO:0070069,GO:1902600" "cytochrome-c oxidase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial electron transport, cytochrome c to oxygen|heme biosynthetic process|heme A biosynthetic process|respiratory gaseous exchange by respiratory system|respiratory chain complex IV assembly|integral component of membrane|oxidoreductase activity, acting on the CH-CH group of donors|oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor|heme binding|cellular respiration|oxidation-reduction process|molecular adaptor activity|cytochrome complex|proton transmembrane transport" "hsa00190,hsa00860,hsa04714" Oxidative phosphorylation|Porphyrin and chlorophyll metabolism|Thermogenesis COX16 37.58578398 43.64310664 31.52846133 0.722415606 -0.469099036 0.625586602 1 1.324367518 0.997956404 51241 cytochrome c oxidase assembly factor COX16 "GO:0003674,GO:0005515,GO:0031305,GO:0033617" molecular_function|protein binding|integral component of mitochondrial inner membrane|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COX17 295.7626714 315.6513062 275.8740366 0.87398351 -0.194322034 0.686638787 1 17.5291942 15.98015991 10063 cytochrome c oxidase copper chaperone COX17 "GO:0005507,GO:0005515,GO:0005737,GO:0005758,GO:0006091,GO:0006825,GO:0008284,GO:0016531,GO:0033617,GO:1903136,GO:1904960" copper ion binding|protein binding|cytoplasm|mitochondrial intermembrane space|generation of precursor metabolites and energy|copper ion transport|positive regulation of cell population proliferation|copper chaperone activity|mitochondrial cytochrome c oxidase assembly|cuprous ion binding|positive regulation of cytochrome-c oxidase activity "hsa00190,hsa04714" Oxidative phosphorylation|Thermogenesis COX18 224.3094745 213.1407534 235.4781956 1.104801366 0.143787009 0.788518039 1 1.571070767 1.810488957 285521 cytochrome c oxidase assembly factor COX18 "GO:0005515,GO:0008535,GO:0031305,GO:0032977,GO:0032979,GO:0033617,GO:0051204,GO:0051205" protein binding|respiratory chain complex IV assembly|integral component of mitochondrial inner membrane|membrane insertase activity|protein insertion into mitochondrial inner membrane from matrix|mitochondrial cytochrome c oxidase assembly|protein insertion into mitochondrial membrane|protein insertion into membrane hsa04714 Thermogenesis COX19 327.7986107 316.6662621 338.9309593 1.07030966 0.098028255 0.836975461 1 3.314327143 3.700162082 90639 cytochrome c oxidase assembly factor COX19 "GO:0005515,GO:0005739,GO:0005758,GO:0005829,GO:0006878,GO:0033617" protein binding|mitochondrion|mitochondrial intermembrane space|cytosol|cellular copper ion homeostasis|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COX20 469.7627937 726.7084734 212.817114 0.29285074 -1.771762556 3.31E-05 0.006630516 14.48454172 4.424528674 116228 cytochrome c oxidase assembly factor COX20 "GO:0005515,GO:0005739,GO:0005743,GO:0016021,GO:0033617" protein binding|mitochondrion|mitochondrial inner membrane|integral component of membrane|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COX4I1 4178.225573 4190.753193 4165.697953 0.994021304 -0.008651323 0.979192848 1 188.6638801 195.6142028 1327 cytochrome c oxidase subunit 4I1 "GO:0004129,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005751,GO:0005829,GO:0006091,GO:0006123,GO:0007584,GO:0016020,GO:0016021,GO:1902600" "cytochrome-c oxidase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|cytosol|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|response to nutrient|membrane|integral component of membrane|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX5A 2993.391911 3008.32949 2978.454331 0.990069187 -0.01439875 0.965029817 1 129.8902608 134.1399262 9377 cytochrome c oxidase subunit 5A "GO:0004129,GO:0005515,GO:0005743,GO:0005751,GO:0006123,GO:0009055,GO:0046872,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|mitochondrial electron transport, cytochrome c to oxygen|electron transfer activity|metal ion binding|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX5B 1140.749142 1199.677955 1081.820329 0.901758947 -0.149186262 0.666507799 1 88.05718289 82.82685616 1329 cytochrome c oxidase subunit 5B "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0006123,GO:0007585,GO:0046872" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial electron transport, cytochrome c to oxygen|respiratory gaseous exchange by respiratory system|metal ion binding" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX6A1 3616.515984 3509.717739 3723.31423 1.060858595 0.085232368 0.789396989 1 331.014566 366.2861809 1337 cytochrome c oxidase subunit 6A1 "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0005751,GO:0006091,GO:0006123,GO:0016021,GO:0030234,GO:0050790,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|integral component of membrane|enzyme regulator activity|regulation of catalytic activity|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX6B1 2103.442297 2115.168238 2091.716356 0.988912522 -0.016085188 0.961647844 1 219.5201012 226.437369 1340 cytochrome c oxidase subunit 6B1 "GO:0004129,GO:0005739,GO:0005743,GO:0006123,GO:0021762,GO:0045277,GO:1902600" "cytochrome-c oxidase activity|mitochondrion|mitochondrial inner membrane|mitochondrial electron transport, cytochrome c to oxygen|substantia nigra development|respiratory chain complex IV|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX6B2 5.552566274 9.134603715 1.970528833 0.215721327 -2.212759283 0.247208451 1 0.220512609 0.049618364 125965 cytochrome c oxidase subunit 6B2 "GO:0005515,GO:0005739,GO:0006119,GO:0030061,GO:0045277" protein binding|mitochondrion|oxidative phosphorylation|mitochondrial crista|respiratory chain complex IV "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX6C 2508.93502 2523.180537 2494.689503 0.988708285 -0.016383173 0.960376582 1 138.0023682 142.3215427 1345 cytochrome c oxidase subunit 6C "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0006091,GO:0006123,GO:0016021,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|integral component of membrane|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX7A2 1150.057936 1095.13749 1204.978381 1.100298723 0.137895258 0.690200238 1 44.12478158 50.64179691 1347 cytochrome c oxidase subunit 7A2 "GO:0002082,GO:0004129,GO:0005515,GO:0005746,GO:0006119,GO:0016021,GO:0022900,GO:0097250,GO:1902600" regulation of oxidative phosphorylation|cytochrome-c oxidase activity|protein binding|mitochondrial respirasome|oxidative phosphorylation|integral component of membrane|electron transport chain|mitochondrial respirasome assembly|proton transmembrane transport "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX7A2L 1535.004604 1378.310205 1691.699003 1.227371746 0.295572279 0.371482088 1 27.27883919 34.9235141 9167 cytochrome c oxidase subunit 7A2 like "GO:0002082,GO:0004129,GO:0005730,GO:0005739,GO:0005743,GO:0005746,GO:0006123,GO:0097250,GO:1902600" "regulation of oxidative phosphorylation|cytochrome-c oxidase activity|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial electron transport, cytochrome c to oxygen|mitochondrial respirasome assembly|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX7B 2453.827515 2797.218649 2110.43638 0.75447673 -0.406451689 0.203122107 1 57.96614426 45.61799495 1349 cytochrome c oxidase subunit 7B "GO:0004129,GO:0005515,GO:0005743,GO:0005746,GO:0006123,GO:0007417,GO:0016021,GO:0045277,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial electron transport, cytochrome c to oxygen|central nervous system development|integral component of membrane|respiratory chain complex IV|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX7C 3500.47747 3524.942078 3476.012862 0.986119143 -0.020166131 0.950387246 1 283.8249301 291.941516 1350 cytochrome c oxidase subunit 7C "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0005751,GO:0006091,GO:0006123,GO:0016021,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|integral component of membrane|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX8A 3129.656307 3567.570229 2691.742386 0.754502985 -0.406401487 0.201638791 1 365.7587985 287.8536058 1351 cytochrome c oxidase subunit 8A "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0006091,GO:0006123,GO:0016021,GO:0045277,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|integral component of membrane|respiratory chain complex IV|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases CP 17.68750057 30.44867905 4.926322083 0.161790995 -2.627796782 0.033492465 0.820898508 0.284156657 0.047954361 1356 ceruloplasmin "GO:0004322,GO:0005507,GO:0005576,GO:0005615,GO:0005765,GO:0005788,GO:0005886,GO:0006825,GO:0006826,GO:0006879,GO:0016491,GO:0043687,GO:0044267,GO:0051087,GO:0055072,GO:0055114,GO:0070062,GO:0072562" ferroxidase activity|copper ion binding|extracellular region|extracellular space|lysosomal membrane|endoplasmic reticulum lumen|plasma membrane|copper ion transport|iron ion transport|cellular iron ion homeostasis|oxidoreductase activity|post-translational protein modification|cellular protein metabolic process|chaperone binding|iron ion homeostasis|oxidation-reduction process|extracellular exosome|blood microparticle "hsa00860,hsa04216" Porphyrin and chlorophyll metabolism|Ferroptosis CPA4 132.7986499 221.2604011 44.33689874 0.200383343 -2.31916551 0.000342739 0.043013733 4.016508515 0.839510705 51200 carboxypeptidase A4 "GO:0004181,GO:0005575,GO:0005615,GO:0006508,GO:0008270,GO:0016573" metallocarboxypeptidase activity|cellular_component|extracellular space|proteolysis|zinc ion binding|histone acetylation CPAMD8 29.21103644 43.64310664 14.77896625 0.338632315 -1.56220844 0.121157518 1 0.357318039 0.1262116 27151 C3 and PZP like alpha-2-macroglobulin domain containing 8 "GO:0001654,GO:0004867,GO:0005615,GO:0005886,GO:0010951" eye development|serine-type endopeptidase inhibitor activity|extracellular space|plasma membrane|negative regulation of endopeptidase activity CPD 4397.170279 4104.481936 4689.858623 1.142618897 0.192344295 0.547324703 1 22.5831103 26.91541545 1362 carboxypeptidase D "GO:0004181,GO:0004185,GO:0005615,GO:0005886,GO:0006518,GO:0008270,GO:0016020,GO:0016021,GO:0016485,GO:0070062" metallocarboxypeptidase activity|serine-type carboxypeptidase activity|extracellular space|plasma membrane|peptide metabolic process|zinc ion binding|membrane|integral component of membrane|protein processing|extracellular exosome CPE 315.8621147 241.5595205 390.164709 1.615190774 0.691704576 0.137635397 1 4.738240721 7.98282991 1363 carboxypeptidase E "GO:0003214,GO:0004180,GO:0004181,GO:0005515,GO:0005615,GO:0005634,GO:0005794,GO:0005886,GO:0006464,GO:0006518,GO:0007218,GO:0008270,GO:0016055,GO:0016485,GO:0030658,GO:0042043,GO:0050839,GO:0070062,GO:0072657" cardiac left ventricle morphogenesis|carboxypeptidase activity|metallocarboxypeptidase activity|protein binding|extracellular space|nucleus|Golgi apparatus|plasma membrane|cellular protein modification process|peptide metabolic process|neuropeptide signaling pathway|zinc ion binding|Wnt signaling pathway|protein processing|transport vesicle membrane|neurexin family protein binding|cell adhesion molecule binding|extracellular exosome|protein localization to membrane hsa04940 Type I diabetes mellitus CPEB2 135.3738962 127.884452 142.8633404 1.117128299 0.159794885 0.803998728 1 0.986279328 1.149261647 132864 cytoplasmic polyadenylation element binding protein 2 "GO:0000900,GO:0003723,GO:0003730,GO:0005095,GO:0005634,GO:0005737,GO:0006412,GO:0008135,GO:0032869,GO:0034260,GO:0034599,GO:0035925,GO:0043005,GO:0043022,GO:0043023,GO:0043024,GO:0045202,GO:0071243,GO:0071456,GO:1900248,GO:1990124,GO:2000766" "translation repressor activity, mRNA regulatory element binding|RNA binding|mRNA 3'-UTR binding|GTPase inhibitor activity|nucleus|cytoplasm|translation|translation factor activity, RNA binding|cellular response to insulin stimulus|negative regulation of GTPase activity|cellular response to oxidative stress|mRNA 3'-UTR AU-rich region binding|neuron projection|ribosome binding|ribosomal large subunit binding|ribosomal small subunit binding|synapse|cellular response to arsenic-containing substance|cellular response to hypoxia|negative regulation of cytoplasmic translational elongation|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation" "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation CPEB3 131.6258336 141.0788796 122.1727877 0.865989211 -0.207579044 0.745734475 1 0.648615428 0.585889461 22849 cytoplasmic polyadenylation element binding protein 3 "GO:0000122,GO:0000900,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0007616,GO:0008135,GO:0014069,GO:0017148,GO:0030014,GO:0030425,GO:0030496,GO:0035613,GO:0035925,GO:0043005,GO:0043022,GO:0045202,GO:0045727,GO:0048167,GO:0060213,GO:0060998,GO:0060999,GO:0061158,GO:0071230,GO:0097440,GO:1900153,GO:1900248,GO:1900365,GO:1990124,GO:2000766" "negative regulation of transcription by RNA polymerase II|translation repressor activity, mRNA regulatory element binding|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|translation|long-term memory|translation factor activity, RNA binding|postsynaptic density|negative regulation of translation|CCR4-NOT complex|dendrite|midbody|RNA stem-loop binding|mRNA 3'-UTR AU-rich region binding|neuron projection|ribosome binding|synapse|positive regulation of translation|regulation of synaptic plasticity|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of dendritic spine development|positive regulation of dendritic spine development|3'-UTR-mediated mRNA destabilization|cellular response to amino acid stimulus|apical dendrite|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of cytoplasmic translational elongation|positive regulation of mRNA polyadenylation|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation" "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation CPEB4 315.8121342 305.5017465 326.1225219 1.067498061 0.094233449 0.845504609 1 1.593961648 1.774846882 80315 cytoplasmic polyadenylation element binding protein 4 "GO:0000900,GO:0002931,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0006412,GO:0008135,GO:0014069,GO:0030425,GO:0030426,GO:0035235,GO:0036294,GO:0042149,GO:0043005,GO:0043022,GO:0043197,GO:0043524,GO:0045202,GO:0046872,GO:0048471,GO:0071230,GO:1990124,GO:2000766" "translation repressor activity, mRNA regulatory element binding|response to ischemia|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|translation|translation factor activity, RNA binding|postsynaptic density|dendrite|growth cone|ionotropic glutamate receptor signaling pathway|cellular response to decreased oxygen levels|cellular response to glucose starvation|neuron projection|ribosome binding|dendritic spine|negative regulation of neuron apoptotic process|synapse|metal ion binding|perinuclear region of cytoplasm|cellular response to amino acid stimulus|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation" "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation CPED1 435.0912333 276.0680234 594.1144432 2.152058163 1.105717069 0.009640136 0.413488604 2.017003964 4.52769002 79974 cadherin like and PC-esterase domain containing 1 GO:0005783 endoplasmic reticulum CPLANE1 972.0531672 915.4902835 1028.616051 1.123568507 0.168088092 0.636387847 1 3.026721927 3.547219068 65250 ciliogenesis and planar polarity effector 1 "GO:0016021,GO:0035869,GO:0060271" integral component of membrane|ciliary transition zone|cilium assembly CPLANE2 52.99099442 52.77771036 53.20427849 1.008082354 0.011613503 1 1 1.447214316 1.521755192 79363 ciliogenesis and planar polarity effector 2 "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0006887,GO:0015031,GO:0017157,GO:0031338,GO:0034613,GO:0036064,GO:0060271" GTPase activity|protein binding|GTP binding|cytoplasm|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|cellular protein localization|ciliary basal body|cilium assembly CPM 50.99077404 50.74779842 51.23374966 1.009575809 0.013749247 1 1 0.369493525 0.389100419 1368 carboxypeptidase M "GO:0004180,GO:0004181,GO:0005576,GO:0005615,GO:0005886,GO:0006518,GO:0008270,GO:0009653,GO:0009986,GO:0016485,GO:0031225,GO:0070062" carboxypeptidase activity|metallocarboxypeptidase activity|extracellular region|extracellular space|plasma membrane|peptide metabolic process|zinc ion binding|anatomical structure morphogenesis|cell surface|protein processing|anchored component of membrane|extracellular exosome CPN2 25.73291943 41.6131947 9.852644165 0.23676731 -2.078458191 0.051475877 1 0.680297453 0.168010535 1370 carboxypeptidase N subunit 2 "GO:0005576,GO:0005615,GO:0030234,GO:0030449,GO:0031012,GO:0050790,GO:0050821,GO:0070062,GO:0072562" extracellular region|extracellular space|enzyme regulator activity|regulation of complement activation|extracellular matrix|regulation of catalytic activity|protein stabilization|extracellular exosome|blood microparticle CPNE1 6752.745011 7391.924318 6113.565705 0.827060105 -0.273935916 0.401961631 1 154.7643198 133.5130894 8904 copine 1 "GO:0001786,GO:0004175,GO:0005215,GO:0005509,GO:0005515,GO:0005544,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006629,GO:0010629,GO:0016020,GO:0016192,GO:0031965,GO:0035577,GO:0042802,GO:0043122,GO:0043312,GO:0043392,GO:0045666,GO:0046474,GO:0051059,GO:0051897,GO:0070062,GO:0071277,GO:1901223,GO:1903265,GO:1990138" phosphatidylserine binding|endopeptidase activity|transporter activity|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|proteolysis|lipid metabolic process|negative regulation of gene expression|membrane|vesicle-mediated transport|nuclear membrane|azurophil granule membrane|identical protein binding|regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|negative regulation of DNA binding|positive regulation of neuron differentiation|glycerophospholipid biosynthetic process|NF-kappaB binding|positive regulation of protein kinase B signaling|extracellular exosome|cellular response to calcium ion|negative regulation of NIK/NF-kappaB signaling|positive regulation of tumor necrosis factor-mediated signaling pathway|neuron projection extension CPNE2 873.1286112 854.5929254 891.664297 1.043378983 0.061263278 0.868177059 1 16.6405678 18.11032128 221184 copine 2 "GO:0005515,GO:0005544,GO:0005634,GO:0005737,GO:0005886,GO:0046872,GO:0070062,GO:0071277" protein binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|plasma membrane|metal ion binding|extracellular exosome|cellular response to calcium ion CPNE3 3986.990251 3510.732695 4463.247807 1.271315191 0.346321755 0.277398792 1 33.49147219 44.4123143 8895 copine 3 "GO:0003723,GO:0004674,GO:0005515,GO:0005544,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005925,GO:0006468,GO:0030054,GO:0030335,GO:0030971,GO:0035577,GO:0038128,GO:0043312,GO:0046474,GO:0046872,GO:0048306,GO:0070062,GO:0071277,GO:0071363" RNA binding|protein serine/threonine kinase activity|protein binding|calcium-dependent phospholipid binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|cytosol|plasma membrane|focal adhesion|protein phosphorylation|cell junction|positive regulation of cell migration|receptor tyrosine kinase binding|azurophil granule membrane|ERBB2 signaling pathway|neutrophil degranulation|glycerophospholipid biosynthetic process|metal ion binding|calcium-dependent protein binding|extracellular exosome|cellular response to calcium ion|cellular response to growth factor stimulus CPNE5 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.046764865 0 57699 copine 5 "GO:0003674,GO:0005544,GO:0005886,GO:0030154,GO:0043005,GO:0043204,GO:0046872,GO:0070062,GO:0071277,GO:1903861" molecular_function|calcium-dependent phospholipid binding|plasma membrane|cell differentiation|neuron projection|perikaryon|metal ion binding|extracellular exosome|cellular response to calcium ion|positive regulation of dendrite extension CPNE7 325.7214398 343.0551173 308.3877624 0.898945233 -0.153694871 0.743372235 1 4.001504253 3.752083082 27132 copine 7 "GO:0005215,GO:0005515,GO:0005544,GO:0005634,GO:0005737,GO:0005886,GO:0006629,GO:0046474,GO:0046872,GO:0070062,GO:0071277" transporter activity|protein binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|plasma membrane|lipid metabolic process|glycerophospholipid biosynthetic process|metal ion binding|extracellular exosome|cellular response to calcium ion CPNE8 579.9775586 549.0911789 610.8639383 1.112500003 0.15380534 0.698948158 1 4.080635529 4.735259207 144402 copine 8 "GO:0003674,GO:0005515,GO:0005544,GO:0005886,GO:0008150,GO:0046872,GO:0070062,GO:0071277" molecular_function|protein binding|calcium-dependent phospholipid binding|plasma membrane|biological_process|metal ion binding|extracellular exosome|cellular response to calcium ion CPO 8.00088154 8.119647747 7.882115332 0.970745971 -0.042834281 1 1 0.018761418 0.018997094 130749 carboxypeptidase O "GO:0004181,GO:0005615,GO:0006508,GO:0008270,GO:0016324,GO:0046658" metallocarboxypeptidase activity|extracellular space|proteolysis|zinc ion binding|apical plasma membrane|anchored component of plasma membrane CPOX 1181.459466 1187.498483 1175.420449 0.989829011 -0.014748768 0.96838495 1 12.30413439 12.70361064 1371 coproporphyrinogen oxidase "GO:0004109,GO:0005737,GO:0005739,GO:0005758,GO:0005829,GO:0006782,GO:0006783,GO:0042803,GO:0055114" coproporphyrinogen oxidase activity|cytoplasm|mitochondrion|mitochondrial intermembrane space|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|protein homodimerization activity|oxidation-reduction process hsa00860 Porphyrin and chlorophyll metabolism CPQ 111.9084211 106.5703767 117.2464656 1.100178767 0.137737964 0.844941168 1 2.79369235 3.205957547 10404 carboxypeptidase Q "GO:0004180,GO:0005615,GO:0005737,GO:0005764,GO:0005783,GO:0005794,GO:0006508,GO:0006590,GO:0042246,GO:0042803,GO:0043171,GO:0043231,GO:0046872,GO:0070062,GO:0070573" carboxypeptidase activity|extracellular space|cytoplasm|lysosome|endoplasmic reticulum|Golgi apparatus|proteolysis|thyroid hormone generation|tissue regeneration|protein homodimerization activity|peptide catabolic process|intracellular membrane-bounded organelle|metal ion binding|extracellular exosome|metallodipeptidase activity CPS1 556.4257304 488.1938208 624.6576401 1.279527953 0.355611665 0.372141319 1 4.10106067 5.473459411 1373 carbamoyl-phosphate synthase 1 "GO:0000050,GO:0004087,GO:0004088,GO:0004175,GO:0005509,GO:0005515,GO:0005524,GO:0005543,GO:0005730,GO:0005737,GO:0005743,GO:0005759,GO:0006207,GO:0006508,GO:0006541,GO:0006807,GO:0007494,GO:0009636,GO:0010043,GO:0014075,GO:0016595,GO:0019240,GO:0019433,GO:0032094,GO:0032496,GO:0032991,GO:0042311,GO:0042493,GO:0042594,GO:0042645,GO:0043200,GO:0044344,GO:0044877,GO:0046209,GO:0050667,GO:0055081,GO:0060416,GO:0070365,GO:0070409,GO:0071242,GO:0071320,GO:0071377,GO:0071400,GO:0071548,GO:0072341" urea cycle|carbamoyl-phosphate synthase (ammonia) activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|endopeptidase activity|calcium ion binding|protein binding|ATP binding|phospholipid binding|nucleolus|cytoplasm|mitochondrial inner membrane|mitochondrial matrix|'de novo' pyrimidine nucleobase biosynthetic process|proteolysis|glutamine metabolic process|nitrogen compound metabolic process|midgut development|response to toxic substance|response to zinc ion|response to amine|glutamate binding|citrulline biosynthetic process|triglyceride catabolic process|response to food|response to lipopolysaccharide|protein-containing complex|vasodilation|response to drug|response to starvation|mitochondrial nucleoid|response to amino acid|cellular response to fibroblast growth factor stimulus|protein-containing complex binding|nitric oxide metabolic process|homocysteine metabolic process|anion homeostasis|response to growth hormone|hepatocyte differentiation|carbamoyl phosphate biosynthetic process|cellular response to ammonium ion|cellular response to cAMP|cellular response to glucagon stimulus|cellular response to oleic acid|response to dexamethasone|modified amino acid binding "hsa00220,hsa00250,hsa00910" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Nitrogen metabolism" CPSF1 4077.191679 3817.249397 4337.133962 1.136193502 0.184208558 0.563635596 1 41.02933266 48.62534373 29894 cleavage and polyadenylation specific factor 1 "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006388,GO:0006406,GO:0019899,GO:0031124,GO:0035925,GO:0098789" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA export from nucleus|enzyme binding|mRNA 3'-end processing|mRNA 3'-UTR AU-rich region binding|pre-mRNA cleavage required for polyadenylation" hsa03015 mRNA surveillance pathway CPSF2 1898.252445 1760.948605 2035.556285 1.15594304 0.20907031 0.518522948 1 6.858866 8.269984251 53981 cleavage and polyadenylation specific factor 2 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006398,GO:0006406,GO:0016020,GO:0031124,GO:0098789" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA 3'-end processing by stem-loop binding and cleavage|mRNA export from nucleus|membrane|mRNA 3'-end processing|pre-mRNA cleavage required for polyadenylation" hsa03015 mRNA surveillance pathway CPSF3 921.4308159 923.6099312 919.2517006 0.995281308 -0.006823745 0.988203201 1 19.91382917 20.67362122 51692 cleavage and polyadenylation specific factor 3 "GO:0000398,GO:0003723,GO:0004521,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006379,GO:0006398,GO:0006406,GO:0008409,GO:0031124,GO:0046872,GO:0090502" "mRNA splicing, via spliceosome|RNA binding|endoribonuclease activity|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|mRNA 3'-end processing by stem-loop binding and cleavage|mRNA export from nucleus|5'-3' exonuclease activity|mRNA 3'-end processing|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" hsa03015 mRNA surveillance pathway CPSF4 869.2051209 822.1143344 916.2959074 1.114560188 0.156474527 0.666770682 1 19.73326578 22.94132097 10898 cleavage and polyadenylation specific factor 4 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0006388,GO:0006406,GO:0008270,GO:0031124,GO:0043231,GO:0046778,GO:0098789,GO:1990837" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA export from nucleus|zinc ion binding|mRNA 3'-end processing|intracellular membrane-bounded organelle|modification by virus of host mRNA processing|pre-mRNA cleavage required for polyadenylation|sequence-specific double-stranded DNA binding" "hsa03015,hsa05164" mRNA surveillance pathway|Influenza A CPSF6 2153.029404 2170.990816 2135.067991 0.983453258 -0.02407161 0.941674519 1 16.41334916 16.83708333 11052 cleavage and polyadenylation specific factor 6 "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005726,GO:0005737,GO:0005847,GO:0005849,GO:0006397,GO:0016020,GO:0016607,GO:0035061,GO:0042382,GO:0043023,GO:0046833,GO:0051262,GO:0051290,GO:0098789,GO:0110104,GO:1990120,GO:1990448,GO:1990904" RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|perichromatin fibrils|cytoplasm|mRNA cleavage and polyadenylation specificity factor complex|mRNA cleavage factor complex|mRNA processing|membrane|nuclear speck|interchromatin granule|paraspeckles|ribosomal large subunit binding|positive regulation of RNA export from nucleus|protein tetramerization|protein heterotetramerization|pre-mRNA cleavage required for polyadenylation|mRNA alternative polyadenylation|messenger ribonucleoprotein complex assembly|exon-exon junction complex binding|ribonucleoprotein complex hsa03015 mRNA surveillance pathway CPSF7 2428.399675 2675.423933 2181.375418 0.815338232 -0.294529429 0.356395522 1 34.81520654 29.60892997 79869 cleavage and polyadenylation specific factor 7 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005847,GO:0005849,GO:0006369,GO:0016020,GO:0031124,GO:0051262,GO:0051290,GO:0098789,GO:0110104,GO:1990120" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA cleavage and polyadenylation specificity factor complex|mRNA cleavage factor complex|termination of RNA polymerase II transcription|membrane|mRNA 3'-end processing|protein tetramerization|protein heterotetramerization|pre-mRNA cleavage required for polyadenylation|mRNA alternative polyadenylation|messenger ribonucleoprotein complex assembly" hsa03015 mRNA surveillance pathway CPT1A 3671.561385 3265.11335 4078.00942 1.248964119 0.320732031 0.313754907 1 28.17626045 36.70702983 1374 carnitine palmitoyltransferase 1A "GO:0001676,GO:0004095,GO:0005739,GO:0005741,GO:0006006,GO:0006631,GO:0006635,GO:0006641,GO:0006853,GO:0007623,GO:0009437,GO:0010883,GO:0014070,GO:0016020,GO:0019216,GO:0030855,GO:0031307,GO:0031667,GO:0032000,GO:0042493,GO:0042755,GO:0042802,GO:0043279,GO:0045471,GO:0046677,GO:0050796,GO:0071398,GO:0097421,GO:1904772,GO:1990698" long-chain fatty acid metabolic process|carnitine O-palmitoyltransferase activity|mitochondrion|mitochondrial outer membrane|glucose metabolic process|fatty acid metabolic process|fatty acid beta-oxidation|triglyceride metabolic process|carnitine shuttle|circadian rhythm|carnitine metabolic process|regulation of lipid storage|response to organic cyclic compound|membrane|regulation of lipid metabolic process|epithelial cell differentiation|integral component of mitochondrial outer membrane|response to nutrient levels|positive regulation of fatty acid beta-oxidation|response to drug|eating behavior|identical protein binding|response to alkaloid|response to ethanol|response to antibiotic|regulation of insulin secretion|cellular response to fatty acid|liver regeneration|response to tetrachloromethane|palmitoleoyltransferase activity "hsa00071,hsa03320,hsa04152,hsa04714,hsa04920,hsa04922,hsa04931" Fatty acid degradation|PPAR signaling pathway|AMPK signaling pathway|Thermogenesis|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance CPT1B 294.7598396 348.1298972 241.3897821 0.693389979 -0.528261108 0.266972658 1 6.41147315 4.637151858 1375 carnitine palmitoyltransferase 1B "GO:0004095,GO:0005515,GO:0005739,GO:0005741,GO:0006631,GO:0006635,GO:0006853,GO:0009437,GO:0009637,GO:0015909,GO:0016021" carnitine O-palmitoyltransferase activity|protein binding|mitochondrion|mitochondrial outer membrane|fatty acid metabolic process|fatty acid beta-oxidation|carnitine shuttle|carnitine metabolic process|response to blue light|long-chain fatty acid transport|integral component of membrane "hsa00071,hsa03320,hsa04152,hsa04714,hsa04920,hsa04922,hsa04931" Fatty acid degradation|PPAR signaling pathway|AMPK signaling pathway|Thermogenesis|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance CPT1C 56.25854897 74.09178569 38.42531225 0.51861771 -0.947256621 0.24819214 1 1.048473754 0.567179906 126129 carnitine palmitoyltransferase 1C "GO:0004095,GO:0005515,GO:0005739,GO:0005741,GO:0005783,GO:0006631,GO:0006635,GO:0009437,GO:0030176,GO:0030424,GO:0030425,GO:0032281,GO:0098794,GO:0098978,GO:0099072" carnitine O-palmitoyltransferase activity|protein binding|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|fatty acid metabolic process|fatty acid beta-oxidation|carnitine metabolic process|integral component of endoplasmic reticulum membrane|axon|dendrite|AMPA glutamate receptor complex|postsynapse|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels "hsa00071,hsa03320,hsa04152,hsa04714,hsa04920,hsa04922" Fatty acid degradation|PPAR signaling pathway|AMPK signaling pathway|Thermogenesis|Adipocytokine signaling pathway|Glucagon signaling pathway CPT2 481.9640381 483.1190409 480.8090353 0.995218558 -0.006914707 0.992348727 1 9.303526647 9.657884368 1376 carnitine palmitoyltransferase 2 "GO:0001676,GO:0004095,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005743,GO:0006635,GO:0006853,GO:0009437,GO:0016746,GO:0019216,GO:0120162" "long-chain fatty acid metabolic process|carnitine O-palmitoyltransferase activity|protein binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial inner membrane|fatty acid beta-oxidation|carnitine shuttle|carnitine metabolic process|transferase activity, transferring acyl groups|regulation of lipid metabolic process|positive regulation of cold-induced thermogenesis" "hsa00071,hsa03320,hsa04714" Fatty acid degradation|PPAR signaling pathway|Thermogenesis CPTP 770.0754456 713.5140458 826.6368455 1.1585432 0.21231184 0.567581401 1 11.88325199 14.36029854 80772 ceramide-1-phosphate transfer protein "GO:0005543,GO:0005640,GO:0005794,GO:0005829,GO:0005886,GO:0006687,GO:0010008,GO:0010507,GO:0016020,GO:0032691,GO:0035627,GO:0046836,GO:0120009,GO:1900226,GO:1902387,GO:1902388,GO:1902389" phospholipid binding|nuclear outer membrane|Golgi apparatus|cytosol|plasma membrane|glycosphingolipid metabolic process|endosome membrane|negative regulation of autophagy|membrane|negative regulation of interleukin-1 beta production|ceramide transport|glycolipid transport|intermembrane lipid transfer|negative regulation of NLRP3 inflammasome complex assembly|ceramide 1-phosphate binding|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport CPVL 766.7091678 988.5671132 544.8512224 0.551152486 -0.859476573 0.020900642 0.623980853 10.52057929 6.048216859 54504 carboxypeptidase vitellogenic like "GO:0004185,GO:0006508,GO:0070062" serine-type carboxypeptidase activity|proteolysis|extracellular exosome CPZ 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.066213747 0.044697006 8532 carboxypeptidase Z "GO:0004181,GO:0005615,GO:0006508,GO:0006518,GO:0008270,GO:0016055,GO:0016485" metallocarboxypeptidase activity|extracellular space|proteolysis|peptide metabolic process|zinc ion binding|Wnt signaling pathway|protein processing CR1L 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.056209884 0.11383196 1379 complement C3b/C4b receptor 1 like "GO:0005515,GO:0005576,GO:0005737,GO:0016020,GO:0030449,GO:0043235,GO:1903659" protein binding|extracellular region|cytoplasm|membrane|regulation of complement activation|receptor complex|regulation of complement-dependent cytotoxicity "hsa04610,hsa04640,hsa05134,hsa05140,hsa05144,hsa05152" Complement and coagulation cascades|Hematopoietic cell lineage|Legionellosis|Leishmaniasis|Malaria|Tuberculosis CR2 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.02444896 0.037134124 1380 complement C3d receptor 2 "GO:0001618,GO:0001848,GO:0002430,GO:0003677,GO:0004875,GO:0004888,GO:0005515,GO:0005886,GO:0006955,GO:0006957,GO:0006958,GO:0016021,GO:0030183,GO:0030449,GO:0042100,GO:0042803,GO:0043235,GO:0046718,GO:0070062" "virus receptor activity|complement binding|complement receptor mediated signaling pathway|DNA binding|complement receptor activity|transmembrane signaling receptor activity|protein binding|plasma membrane|immune response|complement activation, alternative pathway|complement activation, classical pathway|integral component of membrane|B cell differentiation|regulation of complement activation|B cell proliferation|protein homodimerization activity|receptor complex|viral entry into host cell|extracellular exosome" "hsa04610,hsa04640,hsa04662,hsa05169" Complement and coagulation cascades|Hematopoietic cell lineage|B cell receptor signaling pathway|Epstein-Barr virus infection CRABP1 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.278612137 0 1381 cellular retinoic acid binding protein 1 "GO:0001972,GO:0005501,GO:0005515,GO:0005829,GO:0007165,GO:0007275,GO:0016918,GO:0019841,GO:0034653" retinoic acid binding|retinoid binding|protein binding|cytosol|signal transduction|multicellular organism development|retinal binding|retinol binding|retinoic acid catabolic process CRABP2 152.3109432 208.0659735 96.55591282 0.464063927 -1.107604537 0.0616352 1 10.03600719 4.857968613 1382 cellular retinoic acid binding protein 2 "GO:0001972,GO:0005501,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006355,GO:0007165,GO:0008544,GO:0016918,GO:0019841,GO:0030332,GO:0035115,GO:0042573,GO:0048672,GO:0070062" "retinoic acid binding|retinoid binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|regulation of transcription, DNA-templated|signal transduction|epidermis development|retinal binding|retinol binding|cyclin binding|embryonic forelimb morphogenesis|retinoic acid metabolic process|positive regulation of collateral sprouting|extracellular exosome" CRACD 385.0599915 358.2794568 411.8405261 1.149495229 0.201000478 0.649711734 1 2.217203147 2.658450566 57482 capping protein inhibiting regulator of actin dynamics "GO:0005515,GO:0005829,GO:0010669,GO:0030277,GO:0030838,GO:2000813" protein binding|cytosol|epithelial structure maintenance|maintenance of gastrointestinal epithelium|positive regulation of actin filament polymerization|negative regulation of barbed-end actin filament capping CRACDL 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.014467617 343990 CRACD like CRACR2A 384.5970508 360.3093688 408.8847329 1.134815712 0.182458031 0.680810555 1 3.379958962 4.000853943 84766 calcium release activated channel regulator 2A "GO:0002115,GO:0002250,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0016020,GO:0032237,GO:0035580,GO:0043312,GO:0051928" store-operated calcium entry|adaptive immune response|calcium ion binding|protein binding|extracellular region|cytoplasm|membrane|activation of store-operated calcium channel activity|specific granule lumen|neutrophil degranulation|positive regulation of calcium ion transport CRACR2B 74.00543264 108.6002886 39.41057666 0.36289569 -1.462373173 0.053519262 1 1.431603722 0.541901756 283229 calcium release activated channel regulator 2B "GO:0002115,GO:0005509,GO:0005515,GO:0005737,GO:0034613,GO:2001256" store-operated calcium entry|calcium ion binding|protein binding|cytoplasm|cellular protein localization|regulation of store-operated calcium entry CRADD 161.2552734 179.6472064 142.8633404 0.795243874 -0.330530741 0.571903541 1 1.976645068 1.6396266 8738 CASP2 and RIPK1 domain containing adaptor with death domain "GO:0002020,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006919,GO:0006977,GO:0008625,GO:0030674,GO:0042981,GO:0043065,GO:0070513,GO:0071260,GO:0097190,GO:2001235" "protease binding|protein binding|nucleus|cytoplasm|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|extrinsic apoptotic signaling pathway via death domain receptors|protein-macromolecule adaptor activity|regulation of apoptotic process|positive regulation of apoptotic process|death domain binding|cellular response to mechanical stimulus|apoptotic signaling pathway|positive regulation of apoptotic signaling pathway" CRAMP1 810.9881673 782.5310516 839.4452829 1.072730956 0.101288289 0.78471145 1 4.971454737 5.562758841 57585 cramped chromatin regulator homolog 1 "GO:0003677,GO:0003682,GO:0005634,GO:0007389" DNA binding|chromatin binding|nucleus|pattern specification process CRAT 2897.555768 2417.625117 3377.48642 1.397026527 0.482359415 0.13004198 1 36.68190033 53.4530399 1384 carnitine O-acetyltransferase "GO:0003997,GO:0004092,GO:0005739,GO:0005743,GO:0005777,GO:0005782,GO:0005783,GO:0005829,GO:0006625,GO:0008458,GO:0019254,GO:0033540,GO:0046459,GO:0051791" "acyl-CoA oxidase activity|carnitine O-acetyltransferase activity|mitochondrion|mitochondrial inner membrane|peroxisome|peroxisomal matrix|endoplasmic reticulum|cytosol|protein targeting to peroxisome|carnitine O-octanoyltransferase activity|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA oxidase|short-chain fatty acid metabolic process|medium-chain fatty acid metabolic process" hsa04146 Peroxisome CRB1 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.026894283 0.018154748 23418 crumbs cell polarity complex component 1 "GO:0001750,GO:0001917,GO:0001974,GO:0005509,GO:0005515,GO:0005576,GO:0005886,GO:0005902,GO:0005912,GO:0007009,GO:0007157,GO:0007163,GO:0007267,GO:0010001,GO:0010467,GO:0010842,GO:0016021,GO:0016324,GO:0032991,GO:0034613,GO:0035845,GO:0042462,GO:0045197,GO:0045494,GO:0050908,GO:0060060,GO:0061159,GO:0071482" photoreceptor outer segment|photoreceptor inner segment|blood vessel remodeling|calcium ion binding|protein binding|extracellular region|plasma membrane|microvillus|adherens junction|plasma membrane organization|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|establishment or maintenance of cell polarity|cell-cell signaling|glial cell differentiation|gene expression|retina layer formation|integral component of membrane|apical plasma membrane|protein-containing complex|cellular protein localization|photoreceptor cell outer segment organization|eye photoreceptor cell development|establishment or maintenance of epithelial cell apical/basal polarity|photoreceptor cell maintenance|detection of light stimulus involved in visual perception|post-embryonic retina morphogenesis in camera-type eye|establishment of bipolar cell polarity involved in cell morphogenesis|cellular response to light stimulus hsa04390 Hippo signaling pathway CRB3 4.97085941 3.044867905 6.896850916 2.265073931 1.17955814 0.582594813 1 0.117989149 0.27876637 92359 crumbs cell polarity complex component 3 "GO:0005515,GO:0005886,GO:0005923,GO:0016021,GO:0016324,GO:0017124,GO:0019904,GO:0030054,GO:0032991,GO:0070062,GO:0070830,GO:0072659,GO:1901890" protein binding|plasma membrane|bicellular tight junction|integral component of membrane|apical plasma membrane|SH3 domain binding|protein domain specific binding|cell junction|protein-containing complex|extracellular exosome|bicellular tight junction assembly|protein localization to plasma membrane|positive regulation of cell junction assembly "hsa04530,hsa05165" Tight junction|Human papillomavirus infection CRBN 760.6439264 674.945719 846.3421338 1.253941036 0.326469509 0.379491481 1 8.858154859 11.5860744 51185 cereblon "GO:0005515,GO:0005634,GO:0005737,GO:0016020,GO:0016567,GO:0031464,GO:0043161,GO:0046872" protein binding|nucleus|cytoplasm|membrane|protein ubiquitination|Cul4A-RING E3 ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding CRCP 802.9845641 807.9049508 798.0641774 0.987819392 -0.017680804 0.965279136 1 14.59776512 15.04110867 27297 CGRP receptor component "GO:0000166,GO:0001635,GO:0001669,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005829,GO:0005886,GO:0006383,GO:0006384,GO:0007218,GO:0009360,GO:0032481,GO:0045087,GO:0051607" nucleotide binding|calcitonin gene-related peptide receptor activity|acrosomal vesicle|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|cytosol|plasma membrane|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|neuropeptide signaling pathway|DNA polymerase III complex|positive regulation of type I interferon production|innate immune response|defense response to virus CREB1 830.4626041 867.787353 793.1378553 0.9139772 -0.129769918 0.724019364 1 4.457893098 4.249921826 1385 cAMP responsive element binding protein 1 "GO:0000785,GO:0000791,GO:0000978,GO:0000981,GO:0001102,GO:0001225,GO:0001228,GO:0001666,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005759,GO:0006357,GO:0006366,GO:0006468,GO:0007165,GO:0007179,GO:0007409,GO:0007568,GO:0007595,GO:0007613,GO:0007623,GO:0008361,GO:0008542,GO:0010033,GO:0010944,GO:0014823,GO:0016032,GO:0019899,GO:0021983,GO:0030424,GO:0030544,GO:0032916,GO:0033363,GO:0033762,GO:0034670,GO:0035035,GO:0035094,GO:0035497,GO:0035729,GO:0036120,GO:0040018,GO:0042493,GO:0042752,GO:0042802,GO:0043065,GO:0045600,GO:0045672,GO:0045893,GO:0045899,GO:0045944,GO:0046887,GO:0046889,GO:0048145,GO:0050821,GO:0055025,GO:0060251,GO:0060430,GO:0060509,GO:0071294,GO:0071300,GO:0071398,GO:1900273,GO:1901215,GO:1902065,GO:1990090,GO:1990314,GO:1990589,GO:1990763,GO:1990830,GO:1990837" "chromatin|euchromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|mitochondrial matrix|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|protein phosphorylation|signal transduction|transforming growth factor beta receptor signaling pathway|axonogenesis|aging|lactation|memory|circadian rhythm|regulation of cell size|visual learning|response to organic substance|negative regulation of transcription by competitive promoter binding|response to activity|viral process|enzyme binding|pituitary gland development|axon|Hsp70 protein binding|positive regulation of transforming growth factor beta3 production|secretory granule organization|response to glucagon|chemotaxis to arachidonic acid|histone acetyltransferase binding|response to nicotine|cAMP response element binding|cellular response to hepatocyte growth factor stimulus|cellular response to platelet-derived growth factor stimulus|positive regulation of multicellular organism growth|response to drug|regulation of circadian rhythm|identical protein binding|positive regulation of apoptotic process|positive regulation of fat cell differentiation|positive regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of RNA polymerase II transcription preinitiation complex assembly|positive regulation of transcription by RNA polymerase II|positive regulation of hormone secretion|positive regulation of lipid biosynthetic process|regulation of fibroblast proliferation|protein stabilization|positive regulation of cardiac muscle tissue development|regulation of glial cell proliferation|lung saccule development|type I pneumocyte differentiation|cellular response to zinc ion|cellular response to retinoic acid|cellular response to fatty acid|positive regulation of long-term synaptic potentiation|negative regulation of neuron death|response to L-glutamate|cellular response to nerve growth factor stimulus|cellular response to insulin-like growth factor stimulus|ATF4-CREB1 transcription factor complex|arrestin family protein binding|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04380,hsa04612,hsa04668,hsa04710,hsa04713,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05152,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|Osteoclast differentiation|Antigen processing and presentation|TNF signaling pathway|Circadian rhythm|Circadian entrainment|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Viral carcinogenesis|Prostate cancer" TF_bZIP CREB3 1599.089845 1583.331311 1614.848379 1.019905542 0.028435544 0.933066242 1 53.60303825 57.02499921 10488 cAMP responsive element binding protein 3 "GO:0000139,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0005789,GO:0005829,GO:0006357,GO:0006935,GO:0006990,GO:0016021,GO:0016032,GO:0030968,GO:0035497,GO:0045944,GO:0090026,GO:1902236,GO:1990837" "Golgi membrane|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|regulation of transcription by RNA polymerase II|chemotaxis|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|integral component of membrane|viral process|endoplasmic reticulum unfolded protein response|cAMP response element binding|positive regulation of transcription by RNA polymerase II|positive regulation of monocyte chemotaxis|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|sequence-specific double-stranded DNA binding" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05166,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" TF_bZIP CREB3L1 6.926542468 2.029911937 11.823173 5.824475823 2.542128219 0.148475706 1 0.033099768 0.201093356 90993 cAMP responsive element binding protein 3 like 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000981,GO:0001227,GO:0001228,GO:0001649,GO:0003682,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0006357,GO:0007275,GO:0010629,GO:0016020,GO:0016021,GO:0016032,GO:0030968,GO:0032967,GO:0035497,GO:0040037,GO:0045892,GO:0046332,GO:0070278,GO:1902236,GO:1903671,GO:1990440,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|osteoblast differentiation|chromatin binding|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|regulation of transcription by RNA polymerase II|multicellular organism development|negative regulation of gene expression|membrane|integral component of membrane|viral process|endoplasmic reticulum unfolded protein response|positive regulation of collagen biosynthetic process|cAMP response element binding|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of transcription, DNA-templated|SMAD binding|extracellular matrix constituent secretion|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|sequence-specific double-stranded DNA binding" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05166,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" CREB3L2 2871.406921 2718.052083 3024.761759 1.112841721 0.154248414 0.628340567 1 16.06298125 18.64556214 64764 cAMP responsive element binding protein 3 like 2 "GO:0000785,GO:0000976,GO:0000981,GO:0001228,GO:0002062,GO:0005634,GO:0005654,GO:0005783,GO:0005789,GO:0006357,GO:0006888,GO:0009611,GO:0010976,GO:0016021,GO:0030968,GO:0034976,GO:0035497,GO:0045893,GO:0045944,GO:0051216,GO:0097038" "chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chondrocyte differentiation|nucleus|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|regulation of transcription by RNA polymerase II|endoplasmic reticulum to Golgi vesicle-mediated transport|response to wounding|positive regulation of neuron projection development|integral component of membrane|endoplasmic reticulum unfolded protein response|response to endoplasmic reticulum stress|cAMP response element binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cartilage development|perinuclear endoplasmic reticulum" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05166,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" CREB3L4 157.7947238 145.1387035 170.4507441 1.174398971 0.23192261 0.69720467 1 3.205740651 3.926991636 148327 cAMP responsive element binding protein 3 like 4 "GO:0000139,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005783,GO:0005789,GO:0005794,GO:0006357,GO:0007283,GO:0016021,GO:0030968,GO:0031965,GO:0035497,GO:0045944,GO:1990837" "Golgi membrane|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|regulation of transcription by RNA polymerase II|spermatogenesis|integral component of membrane|endoplasmic reticulum unfolded protein response|nuclear membrane|cAMP response element binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05166,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" CREB5 600.1606333 548.0762229 652.2450438 1.190062653 0.251037529 0.522069546 1 2.08896201 2.593082283 9586 cAMP responsive element binding protein 5 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0035497,GO:0045893,GO:0046872,GO:0070062,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|cAMP response element binding|positive regulation of transcription, DNA-templated|metal ion binding|extracellular exosome|sequence-specific double-stranded DNA binding" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05166,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" CREBBP 2200.68087 2532.315141 1869.046598 0.738078199 -0.438154418 0.171764703 1 11.24433004 8.656690518 1387 CREB binding protein "GO:0000122,GO:0000123,GO:0000785,GO:0001085,GO:0001102,GO:0001666,GO:0002039,GO:0002223,GO:0003682,GO:0003684,GO:0003713,GO:0003714,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006355,GO:0006367,GO:0006473,GO:0007165,GO:0007219,GO:0007221,GO:0008134,GO:0008270,GO:0008589,GO:0016032,GO:0016407,GO:0016573,GO:0016604,GO:0018076,GO:0018215,GO:0019216,GO:0030511,GO:0031490,GO:0031648,GO:0032481,GO:0034644,GO:0042592,GO:0042733,GO:0042981,GO:0043426,GO:0045637,GO:0045747,GO:0045893,GO:0045944,GO:0048511,GO:0061418,GO:0061733,GO:0065003,GO:1900034,GO:1904837,GO:1990258" "negative regulation of transcription by RNA polymerase II|histone acetyltransferase complex|chromatin|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|response to hypoxia|p53 binding|stimulatory C-type lectin receptor signaling pathway|chromatin binding|damaged DNA binding|transcription coactivator activity|transcription corepressor activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|protein acetylation|signal transduction|Notch signaling pathway|positive regulation of transcription of Notch receptor target|transcription factor binding|zinc ion binding|regulation of smoothened signaling pathway|viral process|acetyltransferase activity|histone acetylation|nuclear body|N-terminal peptidyl-lysine acetylation|protein phosphopantetheinylation|regulation of lipid metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|chromatin DNA binding|protein destabilization|positive regulation of type I interferon production|cellular response to UV|homeostatic process|embryonic digit morphogenesis|regulation of apoptotic process|MRF binding|regulation of myeloid cell differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|rhythmic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|peptide-lysine-N-acetyltransferase activity|protein-containing complex assembly|regulation of cellular response to heat|beta-catenin-TCF complex assembly|histone glutamine methylation" "hsa04024,hsa04066,hsa04068,hsa04110,hsa04310,hsa04330,hsa04350,hsa04520,hsa04630,hsa04720,hsa04916,hsa04919,hsa04922,hsa04935,hsa05016,hsa05152,hsa05161,hsa05164,hsa05165,hsa05166,hsa05167,hsa05200,hsa05203,hsa05206,hsa05211,hsa05215" "cAMP signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|Wnt signaling pathway|Notch signaling pathway|TGF-beta signaling pathway|Adherens junction|JAK-STAT signaling pathway|Long-term potentiation|Melanogenesis|Thyroid hormone signaling pathway|Glucagon signaling pathway|Growth hormone synthesis, secretion and action|Huntington disease|Tuberculosis|Hepatitis B|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Renal cell carcinoma|Prostate cancer" other CREBL2 1257.863479 988.5671132 1527.159846 1.544821616 0.627440257 0.065168583 1 13.28048722 21.39972911 1389 cAMP responsive element binding protein like 2 "GO:0000785,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006351,GO:0006355,GO:0006357,GO:0007049,GO:0007165,GO:0030154,GO:0033138,GO:0045600,GO:0045893,GO:0046326,GO:0046889,GO:0050821" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle|signal transduction|cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of glucose import|positive regulation of lipid biosynthetic process|protein stabilization" CREBRF 474.0064561 309.5615704 638.4513419 2.062437341 1.044350289 0.012294544 0.4872522 1.932717144 4.157813373 153222 CREB3 regulatory factor "GO:0000977,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030968,GO:0045944" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|endoplasmic reticulum unfolded protein response|positive regulation of transcription by RNA polymerase II" CREBZF 1580.179547 1536.643336 1623.715758 1.056664042 0.079516756 0.810763982 1 10.86342323 11.97345698 58487 CREB/ATF bZIP transcription factor "GO:0000785,GO:0000976,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0009615,GO:0042802,GO:0045814,GO:0045892,GO:0051090" "chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|response to virus|identical protein binding|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|regulation of DNA-binding transcription factor activity" CREG1 592.0261398 530.8219715 653.2303082 1.230601488 0.299363643 0.44613102 1 13.65376345 17.52611835 8804 cellular repressor of E1A stimulated genes 1 "GO:0003714,GO:0005576,GO:0005615,GO:0006357,GO:0007275,GO:0035578,GO:0040008,GO:0043312,GO:0045892,GO:0070062" "transcription corepressor activity|extracellular region|extracellular space|regulation of transcription by RNA polymerase II|multicellular organism development|azurophil granule lumen|regulation of growth|neutrophil degranulation|negative regulation of transcription, DNA-templated|extracellular exosome" CREG2 18.65791921 29.43372308 7.882115332 0.267791992 -1.900815276 0.103197571 1 0.189009032 0.052795399 200407 cellular repressor of E1A stimulated genes 2 "GO:0005615,GO:0005783,GO:0005794" extracellular space|endoplasmic reticulum|Golgi apparatus CRELD1 919.808667 677.9905869 1161.626747 1.713337574 0.776809429 0.030421875 0.779467101 12.49102634 22.3232279 78987 cysteine rich with EGF like domains 1 "GO:0003197,GO:0003279,GO:0003756,GO:0005201,GO:0005509,GO:0005515,GO:0016021,GO:0018215,GO:0062023" endocardial cushion development|cardiac septum development|protein disulfide isomerase activity|extracellular matrix structural constituent|calcium ion binding|protein binding|integral component of membrane|protein phosphopantetheinylation|collagen-containing extracellular matrix CRELD2 738.6454615 787.6058315 689.6850916 0.875672912 -0.191536012 0.609544296 1 20.95034499 19.13590577 79174 cysteine rich with EGF like domains 2 "GO:0003756,GO:0005509,GO:0005515,GO:0005615,GO:0005783,GO:0005794,GO:0018215" protein disulfide isomerase activity|calcium ion binding|protein binding|extracellular space|endoplasmic reticulum|Golgi apparatus|protein phosphopantetheinylation CREM 434.7158834 486.1639089 383.267858 0.788351112 -0.343089782 0.419060024 1 4.154291699 3.416115941 1390 cAMP responsive element modulator "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006006,GO:0006355,GO:0006357,GO:0006631,GO:0007165,GO:0007275,GO:0007283,GO:0008140,GO:0030154,GO:0042752,GO:0048384,GO:0048511,GO:1990589,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|transcription regulator complex|cytoplasm|glucose metabolic process|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|fatty acid metabolic process|signal transduction|multicellular organism development|spermatogenesis|cAMP response element binding protein binding|cell differentiation|regulation of circadian rhythm|retinoic acid receptor signaling pathway|rhythmic process|ATF4-CREB1 transcription factor complex|sequence-specific double-stranded DNA binding" hsa04261 Adrenergic signaling in cardiomyocytes TF_bZIP CRHBP 5.030242514 7.104691779 2.95579325 0.416033987 -1.265226703 0.543955984 1 0.218740167 0.094923399 1393 corticotropin releasing hormone binding protein "GO:0001963,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005767,GO:0005771,GO:0005783,GO:0005794,GO:0005874,GO:0006954,GO:0007165,GO:0007565,GO:0007611,GO:0009755,GO:0030141,GO:0030425,GO:0031045,GO:0035690,GO:0035865,GO:0042277,GO:0043196,GO:0043204,GO:0043679,GO:0045055,GO:0048149,GO:0051424,GO:0051459,GO:0051460,GO:0071277,GO:0071314,GO:0071320,GO:0071356,GO:0071391,GO:0071392,GO:0080135,GO:0097211,GO:1900011,GO:2000310" "synaptic transmission, dopaminergic|protein binding|extracellular region|extracellular space|nucleus|secondary lysosome|multivesicular body|endoplasmic reticulum|Golgi apparatus|microtubule|inflammatory response|signal transduction|female pregnancy|learning or memory|hormone-mediated signaling pathway|secretory granule|dendrite|dense core granule|cellular response to drug|cellular response to potassium ion|peptide binding|varicosity|perikaryon|axon terminus|regulated exocytosis|behavioral response to ethanol|corticotropin-releasing hormone binding|regulation of corticotropin secretion|negative regulation of corticotropin secretion|cellular response to calcium ion|cellular response to cocaine|cellular response to cAMP|cellular response to tumor necrosis factor|cellular response to estrogen stimulus|cellular response to estradiol stimulus|regulation of cellular response to stress|cellular response to gonadotropin-releasing hormone|negative regulation of corticotropin-releasing hormone receptor activity|regulation of NMDA receptor activity" CRIM1 2165.578536 2422.699897 1908.457175 0.787739818 -0.344208894 0.283238346 1 10.9349615 8.984956653 51232 cysteine rich transmembrane BMP regulator 1 "GO:0004867,GO:0005010,GO:0005520,GO:0005576,GO:0005886,GO:0007399,GO:0010951,GO:0016021,GO:0030165,GO:0030514,GO:0045668,GO:0048009" serine-type endopeptidase inhibitor activity|insulin-like growth factor-activated receptor activity|insulin-like growth factor binding|extracellular region|plasma membrane|nervous system development|negative regulation of endopeptidase activity|integral component of membrane|PDZ domain binding|negative regulation of BMP signaling pathway|negative regulation of osteoblast differentiation|insulin-like growth factor receptor signaling pathway CRIP1 2395.47299 2613.511619 2177.434361 0.833145085 -0.263360344 0.409763089 1 196.9719398 171.1752333 1396 cysteine rich protein 1 "GO:0005737,GO:0006955,GO:0007507,GO:0008270,GO:0008630,GO:0010033,GO:0010043,GO:0010468,GO:0042277,GO:0060741,GO:0071236,GO:0071493" cytoplasm|immune response|heart development|zinc ion binding|intrinsic apoptotic signaling pathway in response to DNA damage|response to organic substance|response to zinc ion|regulation of gene expression|peptide binding|prostate gland stromal morphogenesis|cellular response to antibiotic|cellular response to UV-B CRIP2 2095.990709 2144.601961 2047.379458 0.954666411 -0.066931394 0.836166749 1 60.78149056 60.52557425 1397 cysteine rich protein 2 "GO:0005515,GO:0005938,GO:0008270,GO:0008284,GO:0030097" protein binding|cell cortex|zinc ion binding|positive regulation of cell population proliferation|hemopoiesis CRIP3 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.259353881 0 401262 cysteine rich protein 3 "GO:0005737,GO:0046872" cytoplasm|metal ion binding CRIPT 183.2010361 164.4228669 201.9792054 1.228413111 0.296795815 0.596911784 1 1.317007458 1.687518751 9419 CXXC repeat containing interactor of PDZ3 domain "GO:0005515,GO:0005737,GO:0008017,GO:0014069,GO:0030165,GO:0030425,GO:0031122,GO:0035372,GO:0043025,GO:0043197,GO:0043198,GO:0044877,GO:0045184,GO:0097110,GO:1902897" protein binding|cytoplasm|microtubule binding|postsynaptic density|PDZ domain binding|dendrite|cytoplasmic microtubule organization|protein localization to microtubule|neuronal cell body|dendritic spine|dendritic shaft|protein-containing complex binding|establishment of protein localization|scaffold protein binding|regulation of postsynaptic density protein 95 clustering CRISPLD1 4.463381426 2.029911937 6.896850916 3.397610897 1.764520641 0.414871268 1 0.022585211 0.080041223 83690 cysteine rich secretory protein LCCL domain containing 1 "GO:0003674,GO:0005615,GO:0060325,GO:0070062" molecular_function|extracellular space|face morphogenesis|extracellular exosome CRISPLD2 17.98713769 17.25425146 18.72002391 1.084951379 0.117630391 0.971863039 1 0.18032748 0.204074208 83716 cysteine rich secretory protein LCCL domain containing 2 "GO:0005539,GO:0005576,GO:0005615,GO:0008201,GO:0030133,GO:0030198,GO:0030324,GO:0031012,GO:0034774,GO:0043312,GO:0060325,GO:0070062,GO:1904813" glycosaminoglycan binding|extracellular region|extracellular space|heparin binding|transport vesicle|extracellular matrix organization|lung development|extracellular matrix|secretory granule lumen|neutrophil degranulation|face morphogenesis|extracellular exosome|ficolin-1-rich granule lumen CRK 2722.139362 2718.052083 2726.226641 1.003007506 0.004332402 0.990452663 1 35.75577904 37.4081609 1398 "CRK proto-oncogene, adaptor protein" "GO:0000186,GO:0001764,GO:0001784,GO:0001878,GO:0005159,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006629,GO:0008092,GO:0008360,GO:0009966,GO:0014911,GO:0015629,GO:0016020,GO:0016358,GO:0017124,GO:0019221,GO:0019900,GO:0021766,GO:0021987,GO:0030010,GO:0030036,GO:0030159,GO:0031625,GO:0032956,GO:0032991,GO:0033628,GO:0035020,GO:0035591,GO:0035685,GO:0035728,GO:0038026,GO:0038096,GO:0042169,GO:0042542,GO:0043087,GO:0043393,GO:0043621,GO:0045121,GO:0045309,GO:0045953,GO:0046875,GO:0048010,GO:0048013,GO:0050773,GO:0060326,GO:0061045,GO:0061847,GO:0070062,GO:0071560,GO:0071732,GO:0090630,GO:0097110,GO:0098749,GO:1900026,GO:1902531,GO:1990090,GO:1990314,GO:1990782,GO:1990859,GO:2000146,GO:2000404" activation of MAPKK activity|neuron migration|phosphotyrosine residue binding|response to yeast|insulin-like growth factor receptor binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|lipid metabolic process|cytoskeletal protein binding|regulation of cell shape|regulation of signal transduction|positive regulation of smooth muscle cell migration|actin cytoskeleton|membrane|dendrite development|SH3 domain binding|cytokine-mediated signaling pathway|kinase binding|hippocampus development|cerebral cortex development|establishment of cell polarity|actin cytoskeleton organization|signaling receptor complex adaptor activity|ubiquitin protein ligase binding|regulation of actin cytoskeleton organization|protein-containing complex|regulation of cell adhesion mediated by integrin|regulation of Rac protein signal transduction|signaling adaptor activity|helper T cell diapedesis|response to hepatocyte growth factor|reelin-mediated signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|SH2 domain binding|response to hydrogen peroxide|regulation of GTPase activity|regulation of protein binding|protein self-association|membrane raft|protein phosphorylated amino acid binding|negative regulation of natural killer cell mediated cytotoxicity|ephrin receptor binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|regulation of dendrite development|cell chemotaxis|negative regulation of wound healing|response to cholecystokinin|extracellular exosome|cellular response to transforming growth factor beta stimulus|cellular response to nitric oxide|activation of GTPase activity|scaffold protein binding|cerebellar neuron development|positive regulation of substrate adhesion-dependent cell spreading|regulation of intracellular signal transduction|cellular response to nerve growth factor stimulus|cellular response to insulin-like growth factor stimulus|protein tyrosine kinase binding|cellular response to endothelin|negative regulation of cell motility|regulation of T cell migration "hsa04010,hsa04012,hsa04015,hsa04062,hsa04510,hsa04666,hsa04722,hsa04810,hsa04910,hsa04935,hsa05100,hsa05131,hsa05135,hsa05163,hsa05170,hsa05200,hsa05206,hsa05211,hsa05220" "MAPK signaling pathway|ErbB signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Focal adhesion|Fc gamma R-mediated phagocytosis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|Growth hormone synthesis, secretion and action|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Renal cell carcinoma|Chronic myeloid leukemia" CRKL 2566.184031 2900.744158 2231.623903 0.76932807 -0.378329147 0.235626632 1 27.50139618 22.06897946 1399 "CRK like proto-oncogene, adaptor protein" "GO:0000186,GO:0000187,GO:0001558,GO:0001568,GO:0001655,GO:0001764,GO:0001783,GO:0001784,GO:0001933,GO:0001934,GO:0003151,GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0006629,GO:0007254,GO:0007265,GO:0007283,GO:0007338,GO:0007416,GO:0008284,GO:0008543,GO:0008584,GO:0009952,GO:0010629,GO:0016358,GO:0019221,GO:0021766,GO:0021987,GO:0030010,GO:0031594,GO:0032991,GO:0033628,GO:0035556,GO:0035685,GO:0035690,GO:0038026,GO:0042802,GO:0045296,GO:0046579,GO:0048384,GO:0048538,GO:0050773,GO:0050852,GO:0060017,GO:0060326,GO:0060465,GO:0070374,GO:0071560,GO:0086100,GO:0090630,GO:0095500,GO:0098749,GO:0098761,GO:0098890,GO:1900026,GO:1903977,GO:1904393,GO:1904888,GO:2000404" activation of MAPKK activity|activation of MAPK activity|regulation of cell growth|blood vessel development|urogenital system development|neuron migration|B cell apoptotic process|phosphotyrosine residue binding|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|outflow tract morphogenesis|RNA binding|protein binding|nucleoplasm|cytosol|lipid metabolic process|JNK cascade|Ras protein signal transduction|spermatogenesis|single fertilization|synapse assembly|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|male gonad development|anterior/posterior pattern specification|negative regulation of gene expression|dendrite development|cytokine-mediated signaling pathway|hippocampus development|cerebral cortex development|establishment of cell polarity|neuromuscular junction|protein-containing complex|regulation of cell adhesion mediated by integrin|intracellular signal transduction|helper T cell diapedesis|cellular response to drug|reelin-mediated signaling pathway|identical protein binding|cadherin binding|positive regulation of Ras protein signal transduction|retinoic acid receptor signaling pathway|thymus development|regulation of dendrite development|T cell receptor signaling pathway|parathyroid gland development|cell chemotaxis|pharynx development|positive regulation of ERK1 and ERK2 cascade|cellular response to transforming growth factor beta stimulus|endothelin receptor signaling pathway|activation of GTPase activity|acetylcholine receptor signaling pathway|cerebellar neuron development|cellular response to interleukin-7|extrinsic component of postsynaptic membrane|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of glial cell migration|regulation of skeletal muscle acetylcholine-gated channel clustering|cranial skeletal system development|regulation of T cell migration "hsa04010,hsa04012,hsa04015,hsa04062,hsa04510,hsa04666,hsa04722,hsa04810,hsa04910,hsa04935,hsa05100,hsa05131,hsa05135,hsa05163,hsa05170,hsa05200,hsa05206,hsa05211,hsa05220" "MAPK signaling pathway|ErbB signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Focal adhesion|Fc gamma R-mediated phagocytosis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|Growth hormone synthesis, secretion and action|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Renal cell carcinoma|Chronic myeloid leukemia" CRLF1 161.1337856 205.0211056 117.2464656 0.571875101 -0.806228001 0.164103692 1 5.964156076 3.55767374 9244 cytokine receptor like factor 1 "GO:0001657,GO:0004896,GO:0005125,GO:0005127,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0008284,GO:0009897,GO:0019221,GO:0019955,GO:0042531,GO:0043235,GO:0043524,GO:0070106,GO:0097058,GO:2000672" ureteric bud development|cytokine receptor activity|cytokine activity|ciliary neurotrophic factor receptor binding|protein binding|extracellular region|extracellular space|cytosol|positive regulation of cell population proliferation|external side of plasma membrane|cytokine-mediated signaling pathway|cytokine binding|positive regulation of tyrosine phosphorylation of STAT protein|receptor complex|negative regulation of neuron apoptotic process|interleukin-27-mediated signaling pathway|CRLF-CLCF1 complex|negative regulation of motor neuron apoptotic process CRLF3 815.2733994 772.3814919 858.1653068 1.111064048 0.151941984 0.67987849 1 13.61587113 15.7797623 51379 cytokine receptor like factor 3 "GO:0000082,GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0030308,GO:0042802,GO:0045893,GO:0045944,GO:0046427,GO:0071158" "G1/S transition of mitotic cell cycle|DNA binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|negative regulation of cell growth|identical protein binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of receptor signaling pathway via JAK-STAT|positive regulation of cell cycle arrest" CRLS1 1108.908919 1178.363879 1039.453959 0.882116278 -0.180959255 0.602353312 1 24.12286721 22.19579435 54675 cardiolipin synthase 1 "GO:0003841,GO:0005739,GO:0005743,GO:0008808,GO:0016021,GO:0032049,GO:0036148,GO:0043337,GO:0046474,GO:0047144,GO:0097068,GO:1905711" 1-acylglycerol-3-phosphate O-acyltransferase activity|mitochondrion|mitochondrial inner membrane|cardiolipin synthase activity|integral component of membrane|cardiolipin biosynthetic process|phosphatidylglycerol acyl-chain remodeling|CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity|glycerophospholipid biosynthetic process|2-acylglycerol-3-phosphate O-acyltransferase activity|response to thyroxine|response to phosphatidylethanolamine hsa00564 Glycerophospholipid metabolism CRNKL1 1086.270848 1078.898194 1093.643502 1.013667006 0.019583798 0.957903646 1 12.52691138 13.24510012 51340 crooked neck pre-mRNA splicing factor 1 "GO:0000245,GO:0000398,GO:0000974,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0016607,GO:0071007,GO:0071013,GO:0071014" "spliceosomal complex assembly|mRNA splicing, via spliceosome|Prp19 complex|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|nuclear speck|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex" hsa03040 Spliceosome CROCC 385.6538225 398.8776956 372.4299495 0.933694598 -0.098977359 0.826278215 1 2.506731372 2.441341715 9696 "ciliary rootlet coiled-coil, rootletin" "GO:0001917,GO:0003779,GO:0005198,GO:0005200,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0007098,GO:0008104,GO:0010457,GO:0010669,GO:0015629,GO:0019894,GO:0032053,GO:0033365,GO:0035253,GO:0045494,GO:0045724,GO:0051656,GO:0070062,GO:0097729,GO:0120219,GO:1903566" photoreceptor inner segment|actin binding|structural molecule activity|structural constituent of cytoskeleton|protein binding|centrosome|centriole|cytosol|plasma membrane|centrosome cycle|protein localization|centriole-centriole cohesion|epithelial structure maintenance|actin cytoskeleton|kinesin binding|ciliary basal body organization|protein localization to organelle|ciliary rootlet|photoreceptor cell maintenance|positive regulation of cilium assembly|establishment of organelle localization|extracellular exosome|9+2 motile cilium|subapical part of cell|positive regulation of protein localization to cilium CROT 263.4176924 259.8287279 267.0066569 1.027625617 0.03931476 0.944567745 1 2.193966063 2.351693709 54677 carnitine O-octanoyltransferase "GO:0005777,GO:0005782,GO:0005829,GO:0006091,GO:0006625,GO:0006631,GO:0006635,GO:0008458,GO:0009437,GO:0015908,GO:0015936,GO:0033540,GO:0043231,GO:0051791" peroxisome|peroxisomal matrix|cytosol|generation of precursor metabolites and energy|protein targeting to peroxisome|fatty acid metabolic process|fatty acid beta-oxidation|carnitine O-octanoyltransferase activity|carnitine metabolic process|fatty acid transport|coenzyme A metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular membrane-bounded organelle|medium-chain fatty acid metabolic process hsa04146 Peroxisome CRPPA 17.58358014 23.34398727 11.823173 0.506476159 -0.981433737 0.406976487 1 0.20590223 0.108776727 729920 CDP-L-ribitol pyrophosphorylase A "GO:0005829,GO:0007411,GO:0008299,GO:0035269,GO:0042803,GO:0047349,GO:0070567" cytosol|axon guidance|isoprenoid biosynthetic process|protein O-linked mannosylation|protein homodimerization activity|D-ribitol-5-phosphate cytidylyltransferase activity|cytidylyltransferase activity "hsa00040,hsa00515" Pentose and glucuronate interconversions|Mannose type O-glycan biosynthesis CRTAP 11228.91781 10734.17432 11723.66129 1.092181004 0.12721197 0.708337207 1 141.1339723 160.7837353 10491 cartilage associated protein "GO:0005515,GO:0005518,GO:0005615,GO:0005783,GO:0005788,GO:0007283,GO:0018400,GO:0030199,GO:0032991,GO:0050821,GO:0061077,GO:1901874" protein binding|collagen binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|spermatogenesis|peptidyl-proline hydroxylation to 3-hydroxy-L-proline|collagen fibril organization|protein-containing complex|protein stabilization|chaperone-mediated protein folding|negative regulation of post-translational protein modification CRTC1 407.6589683 387.7131799 427.6047568 1.102889401 0.141288123 0.747211363 1 1.74560448 2.008138861 23373 CREB regulated transcription coactivator 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007613,GO:0008140,GO:0014069,GO:0016032,GO:0016604,GO:0030425,GO:0032793,GO:0043025,GO:0043153,GO:0045944,GO:0048511,GO:0051289,GO:0097009,GO:0098978,GO:0099527,GO:1900006,GO:1900273,GO:1902631" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|memory|cAMP response element binding protein binding|postsynaptic density|viral process|nuclear body|dendrite|positive regulation of CREB transcription factor activity|neuronal cell body|entrainment of circadian clock by photoperiod|positive regulation of transcription by RNA polymerase II|rhythmic process|protein homotetramerization|energy homeostasis|glutamatergic synapse|postsynapse to nucleus signaling pathway|positive regulation of dendrite development|positive regulation of long-term synaptic potentiation|negative regulation of membrane hyperpolarization hsa05166 Human T-cell leukemia virus 1 infection CRTC2 1304.323324 1133.705817 1474.940832 1.300990795 0.379610754 0.261283468 1 19.85414943 26.94272011 200186 CREB regulated transcription coactivator 2 "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006094,GO:0008140,GO:0016032,GO:0032793,GO:0042593,GO:0043970,GO:0045944,GO:0051289,GO:0070062,GO:1901998" chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|gluconeogenesis|cAMP response element binding protein binding|viral process|positive regulation of CREB transcription factor activity|glucose homeostasis|histone H3-K9 acetylation|positive regulation of transcription by RNA polymerase II|protein homotetramerization|extracellular exosome|toxin transport "hsa04151,hsa04152,hsa04922,hsa04931,hsa05166" PI3K-Akt signaling pathway|AMPK signaling pathway|Glucagon signaling pathway|Insulin resistance|Human T-cell leukemia virus 1 infection CRTC3 1619.49709 1395.564457 1843.429723 1.320920517 0.401543659 0.221813731 1 10.71402402 14.76200103 64784 CREB regulated transcription coactivator 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008140,GO:0016032,GO:0032793,GO:0042116,GO:0043951,GO:0045944,GO:0050995,GO:0051289,GO:0097009" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cAMP response element binding protein binding|viral process|positive regulation of CREB transcription factor activity|macrophage activation|negative regulation of cAMP-mediated signaling|positive regulation of transcription by RNA polymerase II|negative regulation of lipid catabolic process|protein homotetramerization|energy homeostasis hsa05166 Human T-cell leukemia virus 1 infection CRY1 735.4239281 567.3603863 903.48747 1.59244017 0.67123917 0.073011918 1 10.14646965 16.8536517 1407 cryptochrome circadian regulator 1 "GO:0000122,GO:0003677,GO:0003690,GO:0003904,GO:0003914,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0006094,GO:0006975,GO:0007623,GO:0009416,GO:0009785,GO:0009882,GO:0014823,GO:0018298,GO:0019901,GO:0019902,GO:0019915,GO:0031397,GO:0031398,GO:0032868,GO:0032922,GO:0033762,GO:0035257,GO:0042593,GO:0042752,GO:0042754,GO:0042826,GO:0043153,GO:0045721,GO:0045744,GO:0045892,GO:0070888,GO:0071949,GO:2000001,GO:2000323,GO:2000850" "negative regulation of transcription by RNA polymerase II|DNA binding|double-stranded DNA binding|deoxyribodipyrimidine photo-lyase activity|DNA (6-4) photolyase activity|protein binding|nucleus|cytoplasm|mitochondrion|gluconeogenesis|DNA damage induced protein phosphorylation|circadian rhythm|response to light stimulus|blue light signaling pathway|blue light photoreceptor activity|response to activity|protein-chromophore linkage|protein kinase binding|phosphatase binding|lipid storage|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|response to insulin|circadian regulation of gene expression|response to glucagon|nuclear hormone receptor binding|glucose homeostasis|regulation of circadian rhythm|negative regulation of circadian rhythm|histone deacetylase binding|entrainment of circadian clock by photoperiod|negative regulation of gluconeogenesis|negative regulation of G protein-coupled receptor signaling pathway|negative regulation of transcription, DNA-templated|E-box binding|FAD binding|regulation of DNA damage checkpoint|negative regulation of glucocorticoid receptor signaling pathway|negative regulation of glucocorticoid secretion" hsa04710 Circadian rhythm other CRY2 275.0209004 211.1108414 338.9309593 1.60546449 0.682990755 0.16051644 1 2.489410795 4.168820562 1408 cryptochrome circadian regulator 2 "GO:0000122,GO:0000719,GO:0000976,GO:0003677,GO:0003684,GO:0003697,GO:0003904,GO:0003914,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0007623,GO:0009416,GO:0009785,GO:0009882,GO:0014823,GO:0016607,GO:0018298,GO:0019902,GO:0032515,GO:0032922,GO:0042593,GO:0042752,GO:0042754,GO:0043153,GO:0045892,GO:0071949,GO:2000118,GO:2000323" "negative regulation of transcription by RNA polymerase II|photoreactive repair|transcription regulatory region sequence-specific DNA binding|DNA binding|damaged DNA binding|single-stranded DNA binding|deoxyribodipyrimidine photo-lyase activity|DNA (6-4) photolyase activity|protein binding|extracellular region|nucleus|cytoplasm|cytosol|circadian rhythm|response to light stimulus|blue light signaling pathway|blue light photoreceptor activity|response to activity|nuclear speck|protein-chromophore linkage|phosphatase binding|negative regulation of phosphoprotein phosphatase activity|circadian regulation of gene expression|glucose homeostasis|regulation of circadian rhythm|negative regulation of circadian rhythm|entrainment of circadian clock by photoperiod|negative regulation of transcription, DNA-templated|FAD binding|regulation of sodium-dependent phosphate transport|negative regulation of glucocorticoid receptor signaling pathway" hsa04710 Circadian rhythm CRYAB 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.044467075 0.135076982 1410 crystallin alpha B "GO:0001540,GO:0001666,GO:0002088,GO:0005198,GO:0005212,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0006457,GO:0006936,GO:0007021,GO:0007517,GO:0008017,GO:0009986,GO:0010259,GO:0010941,GO:0014069,GO:0015630,GO:0030018,GO:0030308,GO:0030424,GO:0031109,GO:0031333,GO:0031430,GO:0032355,GO:0032387,GO:0032432,GO:0032991,GO:0042542,GO:0042802,GO:0042803,GO:0043066,GO:0043154,GO:0043197,GO:0043204,GO:0044877,GO:0045892,GO:0046872,GO:0050821,GO:0051082,GO:0051403,GO:0060561,GO:0070062,GO:0071480,GO:0097060,GO:0097512,GO:1900034,GO:1905907,GO:2000378" "amyloid-beta binding|response to hypoxia|lens development in camera-type eye|structural molecule activity|structural constituent of eye lens|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|Golgi apparatus|cytosol|protein folding|muscle contraction|tubulin complex assembly|muscle organ development|microtubule binding|cell surface|multicellular organism aging|regulation of cell death|postsynaptic density|microtubule cytoskeleton|Z disc|negative regulation of cell growth|axon|microtubule polymerization or depolymerization|negative regulation of protein-containing complex assembly|M band|response to estradiol|negative regulation of intracellular transport|actin filament bundle|protein-containing complex|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|dendritic spine|perikaryon|protein-containing complex binding|negative regulation of transcription, DNA-templated|metal ion binding|protein stabilization|unfolded protein binding|stress-activated MAPK cascade|apoptotic process involved in morphogenesis|extracellular exosome|cellular response to gamma radiation|synaptic membrane|cardiac myofibril|regulation of cellular response to heat|negative regulation of amyloid fibril formation|negative regulation of reactive oxygen species metabolic process" "hsa04141,hsa04213" Protein processing in endoplasmic reticulum|Longevity regulating pathway - multiple species CRYBA2 1.970528833 0 3.941057666 Inf Inf 0.26888406 1 0 0.230818908 1412 crystallin beta A2 "GO:0002088,GO:0003674,GO:0005212,GO:0005515,GO:0005575,GO:0007601,GO:0008150,GO:0042802" lens development in camera-type eye|molecular_function|structural constituent of eye lens|protein binding|cellular_component|visual perception|biological_process|identical protein binding CRYBB3 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.023838587 0.008046014 1417 crystallin beta B3 "GO:0002088,GO:0005212,GO:0005515,GO:0007601" lens development in camera-type eye|structural constituent of eye lens|protein binding|visual perception CRYBG1 73.44129315 70.03196182 76.85062449 1.09736501 0.134043481 0.875108715 1 0.353309275 0.404410177 202 crystallin beta-gamma domain containing 1 "GO:0003674,GO:0005575,GO:0008150,GO:0030246" molecular_function|cellular_component|biological_process|carbohydrate binding CRYBG2 9.434240837 5.074779842 13.79370183 2.718088717 1.442592546 0.330110601 1 0.046193331 0.130966084 55057 crystallin beta-gamma domain containing 2 GO:0030246 carbohydrate binding CRYBG3 797.2456837 887.0715164 707.4198511 0.797477811 -0.326483717 0.374841267 1 4.168015855 3.467080299 131544 crystallin beta-gamma domain containing 3 "GO:0002088,GO:0005212,GO:0007601,GO:0008150,GO:0030246,GO:0032991,GO:0051018" lens development in camera-type eye|structural constituent of eye lens|visual perception|biological_process|carbohydrate binding|protein-containing complex|protein kinase A binding CRYGS 21.91334958 16.23929549 27.58740366 1.698805448 0.764520641 0.493262248 1 0.974482261 1.726766095 1427 crystallin gamma S "GO:0002009,GO:0002088,GO:0005212,GO:0005515,GO:0007601" morphogenesis of an epithelium|lens development in camera-type eye|structural constituent of eye lens|protein binding|visual perception CRYL1 237.9074596 233.4398727 242.3750465 1.038276125 0.054190173 0.923704653 1 5.240649835 5.675628223 51084 crystallin lambda 1 "GO:0003857,GO:0005829,GO:0006631,GO:0016616,GO:0019640,GO:0042803,GO:0050104,GO:0055114,GO:0070062,GO:0070403" "3-hydroxyacyl-CoA dehydrogenase activity|cytosol|fatty acid metabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|glucuronate catabolic process to xylulose 5-phosphate|protein homodimerization activity|L-gulonate 3-dehydrogenase activity|oxidation-reduction process|extracellular exosome|NAD+ binding" hsa00040 Pentose and glucuronate interconversions CRYM 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.14318646 0.036246284 1428 crystallin mu "GO:0000122,GO:0003714,GO:0005515,GO:0005737,GO:0005782,GO:0005829,GO:0006554,GO:0007605,GO:0042403,GO:0042562,GO:0042803,GO:0047127,GO:0050661,GO:0055114,GO:0070062,GO:0070324,GO:0070327" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|cytoplasm|peroxisomal matrix|cytosol|lysine catabolic process|sensory perception of sound|thyroid hormone metabolic process|hormone binding|protein homodimerization activity|thiomorpholine-carboxylate dehydrogenase activity|NADP binding|oxidation-reduction process|extracellular exosome|thyroid hormone binding|thyroid hormone transport CRYZ 206.4559488 205.0211056 207.8907919 1.013997029 0.020053425 0.98016947 1 5.00414252 5.292760984 1429 crystallin zeta "GO:0003730,GO:0003960,GO:0005829,GO:0007601,GO:0008270,GO:0042178,GO:0042802,GO:0051289,GO:0055114,GO:0070062,GO:0070402,GO:0070404" mRNA 3'-UTR binding|NADPH:quinone reductase activity|cytosol|visual perception|zinc ion binding|xenobiotic catabolic process|identical protein binding|protein homotetramerization|oxidation-reduction process|extracellular exosome|NADPH binding|NADH binding CRYZL1 341.3790285 369.4439725 313.3140845 0.848069282 -0.237745966 0.603620684 1 11.70903247 10.35781793 9946 crystallin zeta like 1 "GO:0003960,GO:0005829,GO:0050661,GO:0055114,GO:1901661" NADPH:quinone reductase activity|cytosol|NADP binding|oxidation-reduction process|quinone metabolic process CRYZL2P-SEC16B 29.57005667 34.50850292 24.63161041 0.713783802 -0.486440933 0.641011736 1 0.3315754 0.246868069 111240474 CRYZL2P-SEC16B readthrough "GO:0000139,GO:0005515,GO:0005789,GO:0005829,GO:0006888,GO:0006914,GO:0007029,GO:0007030,GO:0007031,GO:0010628,GO:0012507,GO:0015031,GO:0016559,GO:0043231,GO:0048208,GO:0070863,GO:0070971,GO:0070973" Golgi membrane|protein binding|endoplasmic reticulum membrane|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|autophagy|endoplasmic reticulum organization|Golgi organization|peroxisome organization|positive regulation of gene expression|ER to Golgi transport vesicle membrane|protein transport|peroxisome fission|intracellular membrane-bounded organelle|COPII vesicle coating|positive regulation of protein exit from endoplasmic reticulum|endoplasmic reticulum exit site|protein localization to endoplasmic reticulum exit site CS 6600.433322 6274.457796 6926.408848 1.10390556 0.142616754 0.662181039 1 109.0151466 125.5262902 1431 citrate synthase "GO:0003723,GO:0004108,GO:0005634,GO:0005739,GO:0005759,GO:0005975,GO:0006099,GO:0006101,GO:0070062" RNA binding|citrate (Si)-synthase activity|nucleus|mitochondrion|mitochondrial matrix|carbohydrate metabolic process|tricarboxylic acid cycle|citrate metabolic process|extracellular exosome "hsa00020,hsa00630" Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism CSAD 192.855242 218.2155332 167.4949508 0.767566581 -0.381636195 0.486623102 1 2.554159218 2.0449371 51380 cysteine sulfinic acid decarboxylase "GO:0004068,GO:0004782,GO:0005737,GO:0019449,GO:0019452,GO:0030170,GO:0042412" aspartate 1-decarboxylase activity|sulfinoalanine decarboxylase activity|cytoplasm|L-cysteine catabolic process to hypotaurine|L-cysteine catabolic process to taurine|pyridoxal phosphate binding|taurine biosynthetic process hsa00430 Taurine and hypotaurine metabolism CSAG1 370.3795025 432.3712425 308.3877624 0.713247626 -0.487525055 0.271860581 1 25.43330792 18.92165475 158511 chondrosarcoma associated gene 1 CSAG3 9.000991732 9.134603715 8.867379749 0.970745971 -0.042834281 1 1 0.242090766 0.245131854 389903 CSAG family member 3 "GO:0005515,GO:0042493" protein binding|response to drug CSDC2 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.101588813 0.041145979 27254 cold shock domain containing C2 "GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0006397,GO:0008134,GO:0043488" RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|mRNA processing|transcription factor binding|regulation of mRNA stability CSDE1 12526.04588 12049.55726 13002.53451 1.079088155 0.109812729 0.749358097 1 143.7953739 161.8518878 7812 cold shock domain containing E1 "GO:0000932,GO:0003723,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0006446,GO:0008584,GO:0010494,GO:0034063,GO:0035613,GO:0070937,GO:0070966,GO:0075522" "P-body|RNA binding|protein binding|Golgi apparatus|cytosol|plasma membrane|regulation of translational initiation|male gonad development|cytoplasmic stress granule|stress granule assembly|RNA stem-loop binding|CRD-mediated mRNA stability complex|nuclear-transcribed mRNA catabolic process, no-go decay|IRES-dependent viral translational initiation" CSE1L 10106.75335 10097.79693 10115.70976 1.001773935 0.00255698 0.994275052 1 137.367121 143.5385166 1434 chromosome segregation 1 like "GO:0005049,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0006606,GO:0006611,GO:0016020,GO:0070062" nuclear export signal receptor activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|cytosol|protein import into nucleus|protein export from nucleus|membrane|extracellular exosome hsa05132 Salmonella infection CSF1 643.3244697 838.3536299 448.2953095 0.53473295 -0.903109518 0.019481645 0.604243048 9.530786491 5.31595892 1435 colony stimulating factor 1 "GO:0001954,GO:0002158,GO:0002931,GO:0003006,GO:0005125,GO:0005157,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006954,GO:0007169,GO:0008083,GO:0008284,GO:0010628,GO:0010743,GO:0010744,GO:0010759,GO:0016020,GO:0016021,GO:0016604,GO:0019221,GO:0030225,GO:0030278,GO:0030316,GO:0030335,GO:0032270,GO:0032946,GO:0038145,GO:0040018,GO:0042117,GO:0042488,GO:0042802,GO:0042803,GO:0043687,GO:0044267,GO:0045087,GO:0045651,GO:0045657,GO:0045672,GO:0045860,GO:0046579,GO:0048471,GO:0048873,GO:0060444,GO:0060611,GO:0060763,GO:0061518,GO:1901215,GO:1902228,GO:1904141,GO:1990682" positive regulation of cell-matrix adhesion|osteoclast proliferation|response to ischemia|developmental process involved in reproduction|cytokine activity|macrophage colony-stimulating factor receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|inflammatory response|transmembrane receptor protein tyrosine kinase signaling pathway|growth factor activity|positive regulation of cell population proliferation|positive regulation of gene expression|regulation of macrophage derived foam cell differentiation|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage chemotaxis|membrane|integral component of membrane|nuclear body|cytokine-mediated signaling pathway|macrophage differentiation|regulation of ossification|osteoclast differentiation|positive regulation of cell migration|positive regulation of cellular protein metabolic process|positive regulation of mononuclear cell proliferation|macrophage colony-stimulating factor signaling pathway|positive regulation of multicellular organism growth|monocyte activation|positive regulation of odontogenesis of dentin-containing tooth|identical protein binding|protein homodimerization activity|post-translational protein modification|cellular protein metabolic process|innate immune response|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of osteoclast differentiation|positive regulation of protein kinase activity|positive regulation of Ras protein signal transduction|perinuclear region of cytoplasm|homeostasis of number of cells within a tissue|branching involved in mammary gland duct morphogenesis|mammary gland fat development|mammary duct terminal end bud growth|microglial cell proliferation|negative regulation of neuron death|positive regulation of macrophage colony-stimulating factor signaling pathway|positive regulation of microglial cell migration|CSF1-CSF1R complex "hsa04010,hsa04014,hsa04015,hsa04060,hsa04061,hsa04151,hsa04380,hsa04640,hsa04668,hsa05010,hsa05022,hsa05323" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|PI3K-Akt signaling pathway|Osteoclast differentiation|Hematopoietic cell lineage|TNF signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Rheumatoid arthritis CSF2 1343.227661 1301.173551 1385.28177 1.064640277 0.090366051 0.789855278 1 83.62925142 92.87033905 1437 colony stimulating factor 2 "GO:0000165,GO:0001821,GO:0001892,GO:0005125,GO:0005129,GO:0005515,GO:0005576,GO:0005615,GO:0006955,GO:0008083,GO:0008284,GO:0010628,GO:0010744,GO:0019221,GO:0030099,GO:0030223,GO:0030224,GO:0030225,GO:0032747,GO:0034021,GO:0034405,GO:0042045,GO:0042116,GO:0042531,GO:0043011,GO:0043231,GO:0045187,GO:0045637,GO:0045892,GO:0071222,GO:0071803,GO:0097011,GO:0097028,GO:2001240" "MAPK cascade|histamine secretion|embryonic placenta development|cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|protein binding|extracellular region|extracellular space|immune response|growth factor activity|positive regulation of cell population proliferation|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|cytokine-mediated signaling pathway|myeloid cell differentiation|neutrophil differentiation|monocyte differentiation|macrophage differentiation|positive regulation of interleukin-23 production|response to silicon dioxide|response to fluid shear stress|epithelial fluid transport|macrophage activation|positive regulation of tyrosine phosphorylation of STAT protein|myeloid dendritic cell differentiation|intracellular membrane-bounded organelle|regulation of circadian sleep/wake cycle, sleep|regulation of myeloid cell differentiation|negative regulation of transcription, DNA-templated|cellular response to lipopolysaccharide|positive regulation of podosome assembly|cellular response to granulocyte macrophage colony-stimulating factor stimulus|dendritic cell differentiation|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04060,hsa04630,hsa04640,hsa04650,hsa04657,hsa04660,hsa04664,hsa04668,hsa05131,hsa05146,hsa05166,hsa05167,hsa05171,hsa05202,hsa05221,hsa05323" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Hematopoietic cell lineage|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Shigellosis|Amoebiasis|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Coronavirus disease - COVID-19|Transcriptional misregulation in cancer|Acute myeloid leukemia|Rheumatoid arthritis CSF3 23956.91765 22175.77295 25738.06235 1.160638793 0.214919055 0.56555214 1 746.7584233 904.0514395 1440 colony stimulating factor 3 "GO:0005125,GO:0005130,GO:0005576,GO:0005615,GO:0006955,GO:0007275,GO:0008083,GO:0008284,GO:0014068,GO:0019221,GO:0019899,GO:0030838,GO:0030851,GO:0032092,GO:0033138,GO:0045471,GO:0045639,GO:0045944,GO:0050731,GO:0051091,GO:0051897,GO:0071222,GO:0071345,GO:1901215,GO:2000251" cytokine activity|granulocyte colony-stimulating factor receptor binding|extracellular region|extracellular space|immune response|multicellular organism development|growth factor activity|positive regulation of cell population proliferation|positive regulation of phosphatidylinositol 3-kinase signaling|cytokine-mediated signaling pathway|enzyme binding|positive regulation of actin filament polymerization|granulocyte differentiation|positive regulation of protein binding|positive regulation of peptidyl-serine phosphorylation|response to ethanol|positive regulation of myeloid cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of DNA-binding transcription factor activity|positive regulation of protein kinase B signaling|cellular response to lipopolysaccharide|cellular response to cytokine stimulus|negative regulation of neuron death|positive regulation of actin cytoskeleton reorganization "hsa04060,hsa04151,hsa04630,hsa04640,hsa04657,hsa05144,hsa05171" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|IL-17 signaling pathway|Malaria|Coronavirus disease - COVID-19 CSGALNACT1 18.64307343 28.41876711 8.867379749 0.312025491 -1.680264202 0.146698393 1 0.134830005 0.04388262 55790 chondroitin sulfate N-acetylgalactosaminyltransferase 1 "GO:0000139,GO:0001958,GO:0008376,GO:0008955,GO:0015014,GO:0015020,GO:0019276,GO:0030166,GO:0030173,GO:0030198,GO:0030206,GO:0030210,GO:0032580,GO:0046398,GO:0046872,GO:0047237,GO:0047238,GO:0050650,GO:0050651,GO:0050653,GO:0051216" "Golgi membrane|endochondral ossification|acetylgalactosaminyltransferase activity|peptidoglycan glycosyltransferase activity|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|glucuronosyltransferase activity|UDP-N-acetylgalactosamine metabolic process|proteoglycan biosynthetic process|integral component of Golgi membrane|extracellular matrix organization|chondroitin sulfate biosynthetic process|heparin biosynthetic process|Golgi cisterna membrane|UDP-glucuronate metabolic process|metal ion binding|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|chondroitin sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|cartilage development" hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CSGALNACT2 603.6684419 552.1360468 655.200837 1.186665571 0.246913408 0.528416328 1 7.017250427 8.685828448 55454 chondroitin sulfate N-acetylgalactosaminyltransferase 2 "GO:0000139,GO:0005515,GO:0008376,GO:0016020,GO:0030166,GO:0030173,GO:0030206,GO:0032580,GO:0046872,GO:0047237,GO:0047238,GO:0050650,GO:0050651,GO:0050652,GO:0050653" "Golgi membrane|protein binding|acetylgalactosaminyltransferase activity|membrane|proteoglycan biosynthetic process|integral component of Golgi membrane|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|chondroitin sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CSK 2080.499146 2095.884075 2065.114217 0.985318912 -0.021337346 0.948634631 1 39.29993874 40.39100153 1445 C-terminal Src kinase "GO:0002250,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0007420,GO:0008022,GO:0008285,GO:0010989,GO:0018108,GO:0019903,GO:0031295,GO:0032715,GO:0033673,GO:0034236,GO:0034332,GO:0042802,GO:0042997,GO:0043406,GO:0045121,GO:0045779,GO:0046777,GO:0046872,GO:0048709,GO:0050765,GO:0050852,GO:0060368,GO:0070062,GO:0070064,GO:0070373,GO:0071375" adaptive immune response|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|protein phosphorylation|brain development|protein C-terminus binding|negative regulation of cell population proliferation|negative regulation of low-density lipoprotein particle clearance|peptidyl-tyrosine phosphorylation|protein phosphatase binding|T cell costimulation|negative regulation of interleukin-6 production|negative regulation of kinase activity|protein kinase A catalytic subunit binding|adherens junction organization|identical protein binding|negative regulation of Golgi to plasma membrane protein transport|positive regulation of MAP kinase activity|membrane raft|negative regulation of bone resorption|protein autophosphorylation|metal ion binding|oligodendrocyte differentiation|negative regulation of phagocytosis|T cell receptor signaling pathway|regulation of Fc receptor mediated stimulatory signaling pathway|extracellular exosome|proline-rich region binding|negative regulation of ERK1 and ERK2 cascade|cellular response to peptide hormone stimulus hsa05120 Epithelial cell signaling in Helicobacter pylori infection CSKMT 112.0123416 113.6750685 110.3496147 0.970745971 -0.042834281 0.962537044 1 2.391874199 2.421920372 751071 citrate synthase lysine methyltransferase "GO:0005515,GO:0005739,GO:0006479,GO:0016278,GO:0016279,GO:0018023,GO:0018026,GO:0018027" protein binding|mitochondrion|protein methylation|lysine N-methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation CSMD3 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.014484063 0.003666502 114788 CUB and Sushi multiple domains 3 "GO:0005886,GO:0016021,GO:0050773" plasma membrane|integral component of membrane|regulation of dendrite development CSNK1A1 4100.454511 4127.825923 4073.083098 0.986738097 -0.019260883 0.952631363 1 37.14637898 38.2326421 1452 casein kinase 1 alpha 1 "GO:0000777,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005847,GO:0005929,GO:0006468,GO:0007030,GO:0007049,GO:0007165,GO:0007166,GO:0016020,GO:0016055,GO:0016301,GO:0016607,GO:0018105,GO:0030877,GO:0032436,GO:0036064,GO:0045095,GO:0045104,GO:0051301,GO:0090090,GO:0106310,GO:0106311,GO:1904424,GO:1904885,GO:1904886" condensed chromosome kinetochore|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|mRNA cleavage and polyadenylation specificity factor complex|cilium|protein phosphorylation|Golgi organization|cell cycle|signal transduction|cell surface receptor signaling pathway|membrane|Wnt signaling pathway|kinase activity|nuclear speck|peptidyl-serine phosphorylation|beta-catenin destruction complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ciliary basal body|keratin filament|intermediate filament cytoskeleton organization|cell division|negative regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity|regulation of GTP binding|beta-catenin destruction complex assembly|beta-catenin destruction complex disassembly "hsa04310,hsa04340,hsa05010,hsa05022,hsa05165,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Hedgehog signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Breast cancer|Hepatocellular carcinoma|Gastric cancer CSNK1D 2789.069794 2814.4729 2763.666688 0.981948232 -0.026281127 0.935353013 1 21.15196966 21.66483257 1453 casein kinase 1 delta "GO:0000086,GO:0000139,GO:0001934,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005819,GO:0005829,GO:0005876,GO:0005886,GO:0006468,GO:0007020,GO:0007030,GO:0010389,GO:0016055,GO:0018105,GO:0032436,GO:0032922,GO:0033116,GO:0034067,GO:0036064,GO:0042752,GO:0045296,GO:0048208,GO:0048471,GO:0050321,GO:0051225,GO:0061512,GO:0071539,GO:0090263,GO:0097711,GO:0106310,GO:0106311,GO:1905426,GO:1905515,GO:2000052" G2/M transition of mitotic cell cycle|Golgi membrane|positive regulation of protein phosphorylation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|spindle|cytosol|spindle microtubule|plasma membrane|protein phosphorylation|microtubule nucleation|Golgi organization|regulation of G2/M transition of mitotic cell cycle|Wnt signaling pathway|peptidyl-serine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|circadian regulation of gene expression|endoplasmic reticulum-Golgi intermediate compartment membrane|protein localization to Golgi apparatus|ciliary basal body|regulation of circadian rhythm|cadherin binding|COPII vesicle coating|perinuclear region of cytoplasm|tau-protein kinase activity|spindle assembly|protein localization to cilium|protein localization to centrosome|positive regulation of canonical Wnt signaling pathway|ciliary basal body-plasma membrane docking|protein serine kinase activity|protein threonine kinase activity|positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation|non-motile cilium assembly|positive regulation of non-canonical Wnt signaling pathway "hsa04340,hsa04390,hsa04540,hsa04710" Hedgehog signaling pathway|Hippo signaling pathway|Gap junction|Circadian rhythm CSNK1E 3.955903442 1.014955968 6.896850916 6.795221794 2.764520641 0.248209988 1 0.017628237 0.124947752 1454 casein kinase 1 epsilon "GO:0000086,GO:0003723,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006468,GO:0006897,GO:0007165,GO:0010389,GO:0016055,GO:0018105,GO:0032091,GO:0032436,GO:0032922,GO:0042752,GO:0060070,GO:0090263,GO:0097711,GO:0106310,GO:0106311,GO:1903827,GO:1905426,GO:2000052" G2/M transition of mitotic cell cycle|RNA binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|protein phosphorylation|endocytosis|signal transduction|regulation of G2/M transition of mitotic cell cycle|Wnt signaling pathway|peptidyl-serine phosphorylation|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|circadian regulation of gene expression|regulation of circadian rhythm|canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|ciliary basal body-plasma membrane docking|protein serine kinase activity|protein threonine kinase activity|regulation of cellular protein localization|positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation|positive regulation of non-canonical Wnt signaling pathway "hsa04068,hsa04310,hsa04340,hsa04390,hsa04392,hsa04710,hsa05010,hsa05022" FoxO signaling pathway|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species|Circadian rhythm|Alzheimer disease|Pathways of neurodegeneration - multiple diseases CSNK1G1 255.8797515 249.6791682 262.0803348 1.049668407 0.069933649 0.895843275 1 5.519584921 6.043304472 53944 casein kinase 1 gamma 1 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006897,GO:0016055,GO:0018105,GO:0090263,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|endocytosis|Wnt signaling pathway|peptidyl-serine phosphorylation|positive regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity hsa04340 Hedgehog signaling pathway CSNK1G2 1929.87394 1902.027485 1957.720396 1.029280813 0.041636638 0.898980874 1 23.2402852 24.95118982 1455 casein kinase 1 gamma 2 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0006468,GO:0006897,GO:0007165,GO:0016020,GO:0016055,GO:0018105,GO:0030148,GO:0046777,GO:0090263,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|cell cortex|protein phosphorylation|endocytosis|signal transduction|membrane|Wnt signaling pathway|peptidyl-serine phosphorylation|sphingolipid biosynthetic process|protein autophosphorylation|positive regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity hsa04340 Hedgehog signaling pathway CSNK1G3 1259.069947 1205.76769 1312.372203 1.088412149 0.122224965 0.720305139 1 12.08307872 13.71787734 1456 casein kinase 1 gamma 3 "GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0006464,GO:0006897,GO:0007165,GO:0016055,GO:0018105,GO:0090263,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|plasma membrane|cellular protein modification process|endocytosis|signal transduction|Wnt signaling pathway|peptidyl-serine phosphorylation|positive regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity hsa04340 Hedgehog signaling pathway CSNK2A1 7658.281198 7531.988241 7784.574155 1.033535091 0.047587373 0.88550581 1 29.37990089 31.67316643 1457 casein kinase 2 alpha 1 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0005956,GO:0006457,GO:0006468,GO:0006656,GO:0006915,GO:0007049,GO:0007165,GO:0008284,GO:0016055,GO:0016236,GO:0016301,GO:0016580,GO:0016581,GO:0018105,GO:0018107,GO:0030177,GO:0030307,GO:0031519,GO:0042802,GO:0043154,GO:0045732,GO:0047485,GO:0048511,GO:0051726,GO:0051879,GO:0061077,GO:0106310,GO:0106311,GO:1901796,GO:1905818,GO:2000059,GO:2001234" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein kinase CK2 complex|protein folding|protein phosphorylation|phosphatidylcholine biosynthetic process|apoptotic process|cell cycle|signal transduction|positive regulation of cell population proliferation|Wnt signaling pathway|macroautophagy|kinase activity|Sin3 complex|NuRD complex|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of Wnt signaling pathway|positive regulation of cell growth|PcG protein complex|identical protein binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein catabolic process|protein N-terminus binding|rhythmic process|regulation of cell cycle|Hsp90 protein binding|chaperone-mediated protein folding|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|regulation of chromosome separation|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of apoptotic signaling pathway "hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05010,hsa05020,hsa05022,hsa05162,hsa05235" Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Measles|PD-L1 expression and PD-1 checkpoint pathway in cancer CSNK2A2 780.4288868 613.0334049 947.8243687 1.546121893 0.628654063 0.089065854 1 12.56494509 20.26377033 1459 casein kinase 2 alpha 2 "GO:0000785,GO:0001669,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0005956,GO:0006457,GO:0006656,GO:0006915,GO:0007049,GO:0007283,GO:0016055,GO:0016236,GO:0018105,GO:0018107,GO:0021987,GO:0031519,GO:0047485,GO:0051726,GO:0097421,GO:0106310,GO:0106311,GO:1901796,GO:1903146,GO:1903955,GO:1905818,GO:2000059,GO:2001234" chromatin|acrosomal vesicle|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein kinase CK2 complex|protein folding|phosphatidylcholine biosynthetic process|apoptotic process|cell cycle|spermatogenesis|Wnt signaling pathway|macroautophagy|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cerebral cortex development|PcG protein complex|protein N-terminus binding|regulation of cell cycle|liver regeneration|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|regulation of chromosome separation|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of apoptotic signaling pathway "hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05010,hsa05020,hsa05022,hsa05162,hsa05235" Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Measles|PD-L1 expression and PD-1 checkpoint pathway in cancer CSNK2A3 492.232364 511.5378081 472.9269199 0.924519972 -0.113223609 0.78632202 1 19.79189105 19.08620212 283106 casein kinase 2 alpha 3 "hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05010,hsa05020,hsa05022,hsa05162,hsa05235" Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Measles|PD-L1 expression and PD-1 checkpoint pathway in cancer CSNK2B 2411.620735 2302.935092 2520.306378 1.094388802 0.130125374 0.684280812 1 125.5495567 143.318665 1460 casein kinase 2 beta "GO:0003682,GO:0004674,GO:0005102,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005956,GO:0006457,GO:0006656,GO:0007165,GO:0008134,GO:0008285,GO:0010862,GO:0016055,GO:0016236,GO:0018107,GO:0019887,GO:0019904,GO:0031519,GO:0032927,GO:0033211,GO:0034622,GO:0034774,GO:0042802,GO:0043312,GO:0043537,GO:0045859,GO:0046872,GO:0051101,GO:0061154,GO:0070062,GO:1901796,GO:1904813" chromatin binding|protein serine/threonine kinase activity|signaling receptor binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein kinase CK2 complex|protein folding|phosphatidylcholine biosynthetic process|signal transduction|transcription factor binding|negative regulation of cell population proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|Wnt signaling pathway|macroautophagy|peptidyl-threonine phosphorylation|protein kinase regulator activity|protein domain specific binding|PcG protein complex|positive regulation of activin receptor signaling pathway|adiponectin-activated signaling pathway|cellular protein-containing complex assembly|secretory granule lumen|identical protein binding|neutrophil degranulation|negative regulation of blood vessel endothelial cell migration|regulation of protein kinase activity|metal ion binding|regulation of DNA binding|endothelial tube morphogenesis|extracellular exosome|regulation of signal transduction by p53 class mediator|ficolin-1-rich granule lumen "hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05010,hsa05020,hsa05022,hsa05162,hsa05235" Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Measles|PD-L1 expression and PD-1 checkpoint pathway in cancer CSPG4 939.6205974 651.6017317 1227.639463 1.884033457 0.913824585 0.010757212 0.442502635 3.980859951 7.823146077 1464 chondroitin sulfate proteoglycan 4 "GO:0000187,GO:0001525,GO:0001726,GO:0005576,GO:0005654,GO:0005796,GO:0005886,GO:0005887,GO:0005925,GO:0006929,GO:0008283,GO:0008347,GO:0009986,GO:0015026,GO:0016324,GO:0019901,GO:0030206,GO:0030207,GO:0030208,GO:0031258,GO:0035556,GO:0043202,GO:0048008,GO:0048771,GO:0050731,GO:0062023,GO:0070062,GO:0097178" activation of MAPK activity|angiogenesis|ruffle|extracellular region|nucleoplasm|Golgi lumen|plasma membrane|integral component of plasma membrane|focal adhesion|substrate-dependent cell migration|cell population proliferation|glial cell migration|cell surface|coreceptor activity|apical plasma membrane|protein kinase binding|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|lamellipodium membrane|intracellular signal transduction|lysosomal lumen|platelet-derived growth factor receptor signaling pathway|tissue remodeling|positive regulation of peptidyl-tyrosine phosphorylation|collagen-containing extracellular matrix|extracellular exosome|ruffle assembly CSPG5 83.02399175 85.25630134 80.79168216 0.947632971 -0.077599699 0.931489663 1 1.669733525 1.650453374 10675 chondroitin sulfate proteoglycan 5 "GO:0000139,GO:0005515,GO:0005576,GO:0005789,GO:0005794,GO:0005796,GO:0005887,GO:0007010,GO:0007165,GO:0007399,GO:0008083,GO:0009986,GO:0016020,GO:0016021,GO:0030206,GO:0030207,GO:0030208,GO:0030660,GO:0040008,GO:0043202,GO:0045202,GO:0046907,GO:0048858,GO:0098978,GO:0098982,GO:0099055,GO:0099550,GO:0106091,GO:1900026,GO:2000300" "Golgi membrane|protein binding|extracellular region|endoplasmic reticulum membrane|Golgi apparatus|Golgi lumen|integral component of plasma membrane|cytoskeleton organization|signal transduction|nervous system development|growth factor activity|cell surface|membrane|integral component of membrane|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|Golgi-associated vesicle membrane|regulation of growth|lysosomal lumen|synapse|intracellular transport|cell projection morphogenesis|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic membrane|trans-synaptic signaling, modulating synaptic transmission|glial cell projection elongation|positive regulation of substrate adhesion-dependent cell spreading|regulation of synaptic vesicle exocytosis" CSPP1 731.7189191 785.5759195 677.8619186 0.862885307 -0.212759283 0.570920903 1 5.3304728 4.797718198 79848 centrosome and spindle pole associated protein 1 "GO:0000922,GO:0005737,GO:0005813,GO:0005819,GO:0005874,GO:0032467,GO:0051781" spindle pole|cytoplasm|centrosome|spindle|microtubule|positive regulation of cytokinesis|positive regulation of cell division CSRNP1 456.015113 527.7771036 384.2531225 0.728059478 -0.457871781 0.274042734 1 7.269526355 5.520633355 64651 cysteine and serine rich nuclear protein 1 "GO:0000785,GO:0000981,GO:0001228,GO:0003674,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0006915,GO:0009791,GO:0043565,GO:0045944,GO:0048008,GO:0048705,GO:0060021,GO:0060325" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|molecular_function|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|apoptotic process|post-embryonic development|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|roof of mouth development|face morphogenesis" CSRNP2 933.8020449 792.6806113 1074.923478 1.356061273 0.439422367 0.218138132 1 7.000257463 9.901688423 81566 cysteine and serine rich nuclear protein 2 "GO:0000785,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0006915,GO:0010923,GO:0019902,GO:0043565,GO:0045944" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|apoptotic process|negative regulation of phosphatase activity|phosphatase binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II" CSRNP3 85.01208796 52.77771036 117.2464656 2.221514817 1.151543764 0.109436969 1 0.211237936 0.489482376 80034 cysteine and serine rich nuclear protein 3 "GO:0000785,GO:0000981,GO:0003700,GO:0005634,GO:0006357,GO:0006915,GO:0010923,GO:0043065,GO:0043565,GO:0045944" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|apoptotic process|negative regulation of phosphatase activity|positive regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II" CSRP1 2428.719602 2596.257367 2261.181836 0.870939016 -0.199356392 0.532661268 1 60.09656152 54.59505403 1465 cysteine and glycine rich protein 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005925,GO:0008270,GO:0008307,GO:0030018,GO:0030036,GO:0042805,GO:0045214,GO:0060537,GO:0070062,GO:0070527" RNA binding|protein binding|nucleus|cytoplasm|focal adhesion|zinc ion binding|structural constituent of muscle|Z disc|actin cytoskeleton organization|actinin binding|sarcomere organization|muscle tissue development|extracellular exosome|platelet aggregation CSRP2 538.7300651 558.2257826 519.2343475 0.930151139 -0.104462938 0.798155606 1 31.13674734 30.20944138 1466 cysteine and glycine rich protein 2 "GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005925,GO:0007275,GO:0008307,GO:0030018,GO:0030036,GO:0030154,GO:0042805,GO:0045214,GO:0046872,GO:0060537" molecular_function|protein binding|nucleus|cytoplasm|focal adhesion|multicellular organism development|structural constituent of muscle|Z disc|actin cytoskeleton organization|cell differentiation|actinin binding|sarcomere organization|metal ion binding|muscle tissue development CST3 3033.775628 2973.820987 3093.730268 1.04032162 0.057029613 0.858590091 1 42.39052688 45.99942135 1471 cystatin C "GO:0001540,GO:0002020,GO:0004866,GO:0004869,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005788,GO:0005794,GO:0005886,GO:0006952,GO:0010466,GO:0010711,GO:0010716,GO:0010951,GO:0030414,GO:0034103,GO:0042802,GO:0043312,GO:0043687,GO:0044267,GO:0045861,GO:0060311,GO:0060313,GO:0070062,GO:0097435,GO:1904724,GO:1904813" amyloid-beta binding|protease binding|endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|plasma membrane|defense response|negative regulation of peptidase activity|negative regulation of collagen catabolic process|negative regulation of extracellular matrix disassembly|negative regulation of endopeptidase activity|peptidase inhibitor activity|regulation of tissue remodeling|identical protein binding|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|negative regulation of proteolysis|negative regulation of elastin catabolic process|negative regulation of blood vessel remodeling|extracellular exosome|supramolecular fiber organization|tertiary granule lumen|ficolin-1-rich granule lumen hsa04970 Salivary secretion CSTA 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.345456581 0.139918451 1475 cystatin A "GO:0001533,GO:0002020,GO:0004869,GO:0005515,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0010466,GO:0010951,GO:0018149,GO:0030216,GO:0045861,GO:0070268,GO:0098609" cornified envelope|protease binding|cysteine-type endopeptidase inhibitor activity|protein binding|extracellular space|nucleoplasm|cytoplasm|cytosol|negative regulation of peptidase activity|negative regulation of endopeptidase activity|peptide cross-linking|keratinocyte differentiation|negative regulation of proteolysis|cornification|cell-cell adhesion CSTB 2191.4129 2134.452401 2248.373399 1.05337247 0.07501566 0.816021279 1 183.8477623 202.0022663 1476 cystatin B "GO:0002020,GO:0003723,GO:0004866,GO:0004869,GO:0005576,GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0008344,GO:0010466,GO:0010951,GO:0034774,GO:0043312,GO:0045861,GO:0062023,GO:0070062,GO:1904724,GO:1904813" protease binding|RNA binding|endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|extracellular region|extracellular space|nucleus|nucleolus|cytoplasm|cytosol|adult locomotory behavior|negative regulation of peptidase activity|negative regulation of endopeptidase activity|secretory granule lumen|neutrophil degranulation|negative regulation of proteolysis|collagen-containing extracellular matrix|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen CSTF1 1700.990237 1948.715459 1453.265014 0.745755368 -0.423225638 0.195516942 1 22.91515286 17.8252273 1477 cleavage stimulation factor subunit 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005848,GO:0006369,GO:0031124" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|mRNA cleavage stimulating factor complex|termination of RNA polymerase II transcription|mRNA 3'-end processing" hsa03015 mRNA surveillance pathway CSTF2 800.5901887 879.9668246 721.2135529 0.819591754 -0.287022626 0.435123827 1 16.94570925 14.48682655 1478 cleavage stimulation factor subunit 2 "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006388,GO:0016604,GO:0031124,GO:0071920,GO:0098789" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|tRNA splicing, via endonucleolytic cleavage and ligation|nuclear body|mRNA 3'-end processing|cleavage body|pre-mRNA cleavage required for polyadenylation" hsa03015 mRNA surveillance pathway CSTF2T 992.3589675 1057.584119 927.133816 0.876652551 -0.189922931 0.591487615 1 13.03233691 11.9169668 23283 cleavage stimulation factor subunit 2 tau variant "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0031124,GO:0043231,GO:0098789" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA 3'-end processing|intracellular membrane-bounded organelle|pre-mRNA cleavage required for polyadenylation" hsa03015 mRNA surveillance pathway CSTF3 604.5267753 644.4970399 564.5565107 0.875964474 -0.191055734 0.626428601 1 10.2970036 9.408346153 1479 cleavage stimulation factor subunit 3 "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006369,GO:0006378,GO:0006379,GO:0031123,GO:0031124" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|RNA 3'-end processing|mRNA 3'-end processing" hsa03015 mRNA surveillance pathway CSTL1 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.209526926 0.212158955 128817 cystatin like 1 "GO:0004869,GO:0005576,GO:0010951" cysteine-type endopeptidase inhibitor activity|extracellular region|negative regulation of endopeptidase activity CTAGE15 2.463161041 0 4.926322083 Inf Inf 0.189235799 1 0 0.1005985 441294 CTAGE family member 15 "GO:0005789,GO:0006888,GO:0009306,GO:0016021,GO:0035459,GO:0070971" endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|integral component of membrane|vesicle cargo loading|endoplasmic reticulum exit site CTAGE4 4.493072978 4.059823873 4.926322083 1.213432463 0.279093814 1 1 0.078299984 0.099104463 100128553 CTAGE family member 4 "GO:0005575,GO:0005789,GO:0006888,GO:0008150,GO:0009306,GO:0016021,GO:0035459,GO:0070971" cellular_component|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|biological_process|protein secretion|integral component of membrane|vesicle cargo loading|endoplasmic reticulum exit site CTAGE8 4.493072978 4.059823873 4.926322083 1.213432463 0.279093814 1 1 0.06609314 0.083654233 100142659 CTAGE family member 8 "GO:0005789,GO:0006888,GO:0009306,GO:0016021,GO:0035459,GO:0070971" endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|integral component of membrane|vesicle cargo loading|endoplasmic reticulum exit site CTBP1 2930.061083 2888.564686 2971.55748 1.028731499 0.040866485 0.898806662 1 14.16906645 15.20404705 1487 C-terminal binding protein 1 "GO:0000122,GO:0001226,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006342,GO:0006468,GO:0008022,GO:0008134,GO:0008285,GO:0016616,GO:0017053,GO:0019079,GO:0019904,GO:0031065,GO:0035067,GO:0042802,GO:0045892,GO:0050872,GO:0051287,GO:0051726,GO:0055114,GO:0070491,GO:0090241" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|chromatin silencing|protein phosphorylation|protein C-terminus binding|transcription factor binding|negative regulation of cell population proliferation|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|transcription repressor complex|viral genome replication|protein domain specific binding|positive regulation of histone deacetylation|negative regulation of histone acetylation|identical protein binding|negative regulation of transcription, DNA-templated|white fat cell differentiation|NAD binding|regulation of cell cycle|oxidation-reduction process|repressing transcription factor binding|negative regulation of histone H4 acetylation" "hsa04310,hsa04330,hsa05200,hsa05220" Wnt signaling pathway|Notch signaling pathway|Pathways in cancer|Chronic myeloid leukemia CTBP2 1116.505006 1024.090572 1208.919439 1.180480977 0.239374793 0.48958058 1 4.119991636 5.073074698 1488 C-terminal binding protein 2 "GO:0000122,GO:0001226,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0008285,GO:0016081,GO:0016616,GO:0017053,GO:0019079,GO:0019901,GO:0035563,GO:0042974,GO:0044877,GO:0045892,GO:0045944,GO:0048386,GO:0048790,GO:0050872,GO:0051287,GO:0055114,GO:0098684,GO:0098831,GO:0098882,GO:0098978,GO:0098982,GO:0099523,GO:1990830" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|negative regulation of cell population proliferation|synaptic vesicle docking|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|transcription repressor complex|viral genome replication|protein kinase binding|positive regulation of chromatin binding|retinoic acid receptor binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of retinoic acid receptor signaling pathway|maintenance of presynaptic active zone structure|white fat cell differentiation|NAD binding|oxidation-reduction process|photoreceptor ribbon synapse|presynaptic active zone cytoplasmic component|structural constituent of presynaptic active zone|glutamatergic synapse|GABA-ergic synapse|presynaptic cytosol|cellular response to leukemia inhibitory factor" "hsa04310,hsa04330,hsa05200,hsa05220" Wnt signaling pathway|Notch signaling pathway|Pathways in cancer|Chronic myeloid leukemia other CTBS 307.7491479 326.8158218 288.682474 0.883318538 -0.178994305 0.707096026 1 2.518957303 2.320887455 1486 chitobiase "GO:0004568,GO:0005615,GO:0005764,GO:0006032,GO:0008061,GO:0009313" chitinase activity|extracellular space|lysosome|chitin catabolic process|chitin binding|oligosaccharide catabolic process CTC1 775.2717133 698.2897062 852.2537203 1.220487303 0.287457287 0.437469879 1 5.024280466 6.396215245 80169 CST telomere replication complex component 1 "GO:0000723,GO:0000781,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006974,GO:0010389,GO:0010833,GO:0016233,GO:0032211,GO:0035264,GO:0042162,GO:0045740,GO:0048146,GO:0048536,GO:0048538,GO:0048539,GO:0071425,GO:0090399,GO:0098505,GO:1990879" "telomere maintenance|chromosome, telomeric region|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytosol|cellular response to DNA damage stimulus|regulation of G2/M transition of mitotic cell cycle|telomere maintenance via telomere lengthening|telomere capping|negative regulation of telomere maintenance via telomerase|multicellular organism growth|telomeric DNA binding|positive regulation of DNA replication|positive regulation of fibroblast proliferation|spleen development|thymus development|bone marrow development|hematopoietic stem cell proliferation|replicative senescence|G-rich strand telomeric DNA binding|CST complex" CTCF 1316.802187 1515.329261 1118.275113 0.737975001 -0.438356149 0.193979809 1 19.72906974 15.18672707 10664 CCCTC-binding factor "GO:0000122,GO:0000775,GO:0000793,GO:0000976,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006306,GO:0006349,GO:0006357,GO:0007059,GO:0008270,GO:0008285,GO:0010216,GO:0010628,GO:0016584,GO:0031060,GO:0035065,GO:0040029,GO:0040030,GO:0043035,GO:0043565,GO:0045892,GO:0045893,GO:0070602,GO:0071459,GO:0071514" "negative regulation of transcription by RNA polymerase II|chromosome, centromeric region|condensed chromosome|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription by RNA polymerase II|chromosome segregation|zinc ion binding|negative regulation of cell population proliferation|maintenance of DNA methylation|positive regulation of gene expression|nucleosome positioning|regulation of histone methylation|regulation of histone acetylation|regulation of gene expression, epigenetic|regulation of molecular function, epigenetic|chromatin insulator sequence binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of centromeric sister chromatid cohesion|protein localization to chromosome, centromeric region|genetic imprinting" zf-C2H2 CTDNEP1 3034.561216 2859.130963 3209.991469 1.122715787 0.166992759 0.599955954 1 74.37334199 87.09697194 23399 CTD nuclear envelope phosphatase 1 "GO:0004721,GO:0004722,GO:0005515,GO:0005635,GO:0005737,GO:0005789,GO:0005811,GO:0006470,GO:0006998,GO:0007077,GO:0007276,GO:0007498,GO:0010867,GO:0016021,GO:0031965,GO:0034504,GO:0071595,GO:0090263,GO:0106306,GO:0106307" phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|nuclear envelope|cytoplasm|endoplasmic reticulum membrane|lipid droplet|protein dephosphorylation|nuclear envelope organization|mitotic nuclear envelope disassembly|gamete generation|mesoderm development|positive regulation of triglyceride biosynthetic process|integral component of membrane|nuclear membrane|protein localization to nucleus|Nem1-Spo7 phosphatase complex|positive regulation of canonical Wnt signaling pathway|protein serine phosphatase activity|protein threonine phosphatase activity CTDP1 853.9968649 961.163302 746.8304277 0.777006806 -0.364000859 0.315761018 1 12.32081257 9.985736545 9150 CTD phosphatase subunit 1 "GO:0000922,GO:0001096,GO:0004721,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005819,GO:0006366,GO:0006368,GO:0006470,GO:0008420,GO:0010458,GO:0030496,GO:0030957,GO:0032991,GO:0043231,GO:0043923,GO:0050434,GO:0051233,GO:0051301,GO:0061052,GO:0070940,GO:0106306,GO:0106307" spindle pole|TFIIF-class transcription factor complex binding|phosphoprotein phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|spindle|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|protein dephosphorylation|RNA polymerase II CTD heptapeptide repeat phosphatase activity|exit from mitosis|midbody|Tat protein binding|protein-containing complex|intracellular membrane-bounded organelle|positive regulation by host of viral transcription|positive regulation of viral transcription|spindle midzone|cell division|negative regulation of cell growth involved in cardiac muscle cell development|dephosphorylation of RNA polymerase II C-terminal domain|protein serine phosphatase activity|protein threonine phosphatase activity CTDSP1 1767.627959 1789.367372 1745.888546 0.975701565 -0.035488152 0.914904238 1 22.48205033 22.88067578 58190 CTD small phosphatase 1 "GO:0004721,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006470,GO:0008420,GO:0046872,GO:0070062,GO:0106306,GO:0106307" phosphoprotein phosphatase activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|protein dephosphorylation|RNA polymerase II CTD heptapeptide repeat phosphatase activity|metal ion binding|extracellular exosome|protein serine phosphatase activity|protein threonine phosphatase activity CTDSP2 6740.150842 5857.310893 7622.990791 1.301448895 0.380118662 0.245009209 1 36.95218403 50.16296065 10106 CTD small phosphatase 2 "GO:0001933,GO:0004721,GO:0005515,GO:0005654,GO:0006470,GO:0008420,GO:0036498,GO:0046872,GO:0106306,GO:0106307,GO:2000134" negative regulation of protein phosphorylation|phosphoprotein phosphatase activity|protein binding|nucleoplasm|protein dephosphorylation|RNA polymerase II CTD heptapeptide repeat phosphatase activity|IRE1-mediated unfolded protein response|metal ion binding|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of G1/S transition of mitotic cell cycle CTDSPL 1343.477317 1351.92135 1335.033284 0.987508101 -0.018135512 0.959382133 1 13.07428816 13.4671175 10217 CTD small phosphatase like "GO:0001933,GO:0003674,GO:0004721,GO:0005515,GO:0005634,GO:0006470,GO:0008150,GO:0008420,GO:0046872,GO:0070062,GO:0106306,GO:0106307,GO:2000134" negative regulation of protein phosphorylation|molecular_function|phosphoprotein phosphatase activity|protein binding|nucleus|protein dephosphorylation|biological_process|RNA polymerase II CTD heptapeptide repeat phosphatase activity|metal ion binding|extracellular exosome|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of G1/S transition of mitotic cell cycle CTDSPL2 715.4135595 647.5419078 783.2852112 1.2096286 0.274564155 0.465992856 1 5.598448829 7.063756 51496 CTD small phosphatase like 2 "GO:0004721,GO:0005515,GO:0005654,GO:0006470,GO:0008420,GO:0030514,GO:0046827" phosphoprotein phosphatase activity|protein binding|nucleoplasm|protein dephosphorylation|RNA polymerase II CTD heptapeptide repeat phosphatase activity|negative regulation of BMP signaling pathway|positive regulation of protein export from nucleus CTF1 10.00110192 10.14955968 9.852644165 0.970745971 -0.042834281 1 1 0.289926335 0.293568323 1489 cardiotrophin 1 "GO:0005125,GO:0005146,GO:0005515,GO:0005576,GO:0005615,GO:0007166,GO:0007267,GO:0007517,GO:0008284,GO:0019221,GO:0030182,GO:0042531,GO:0048666,GO:0048861" cytokine activity|leukemia inhibitory factor receptor binding|protein binding|extracellular region|extracellular space|cell surface receptor signaling pathway|cell-cell signaling|muscle organ development|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|neuron differentiation|positive regulation of tyrosine phosphorylation of STAT protein|neuron development|leukemia inhibitory factor signaling pathway "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway CTH 71.80009299 58.86744617 84.73273982 1.439381956 0.525449478 0.492245796 1 1.244855314 1.869006713 1491 cystathionine gamma-lyase "GO:0000098,GO:0004123,GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0006534,GO:0016846,GO:0018272,GO:0019343,GO:0019344,GO:0019346,GO:0030170,GO:0030968,GO:0042802,GO:0043123,GO:0044524,GO:0044540,GO:0051092,GO:0051289,GO:0070062,GO:0070814,GO:0080146,GO:1904831,GO:1990830,GO:2001234" sulfur amino acid catabolic process|cystathionine gamma-lyase activity|protein binding|calmodulin binding|cytoplasm|cytosol|cysteine metabolic process|carbon-sulfur lyase activity|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine|cysteine biosynthetic process via cystathionine|cysteine biosynthetic process|transsulfuration|pyridoxal phosphate binding|endoplasmic reticulum unfolded protein response|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein sulfhydration|L-cystine L-cysteine-lyase (deaminating)|positive regulation of NF-kappaB transcription factor activity|protein homotetramerization|extracellular exosome|hydrogen sulfide biosynthetic process|L-cysteine desulfhydrase activity|positive regulation of aortic smooth muscle cell differentiation|cellular response to leukemia inhibitory factor|negative regulation of apoptotic signaling pathway "hsa00260,hsa00270,hsa00450" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Selenocompound metabolism" CTHRC1 281.6666108 362.3392807 200.993941 0.554711983 -0.850189203 0.078747857 1 13.17387388 7.622492029 115908 collagen triple helix repeat containing 1 "GO:0005109,GO:0005201,GO:0005576,GO:0005581,GO:0005615,GO:0005737,GO:0016477,GO:0017147,GO:0032092,GO:0033690,GO:0043932,GO:0045669,GO:0060071,GO:0060122,GO:0062023,GO:0090090,GO:0090103,GO:0090177" "frizzled binding|extracellular matrix structural constituent|extracellular region|collagen trimer|extracellular space|cytoplasm|cell migration|Wnt-protein binding|positive regulation of protein binding|positive regulation of osteoblast proliferation|ossification involved in bone remodeling|positive regulation of osteoblast differentiation|Wnt signaling pathway, planar cell polarity pathway|inner ear receptor cell stereocilium organization|collagen-containing extracellular matrix|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|establishment of planar polarity involved in neural tube closure" CTIF 982.5793145 894.1762081 1070.982421 1.19773084 0.260303735 0.462033342 1 6.388329874 7.981095281 9811 cap binding complex dependent translation initiation factor "GO:0000184,GO:0003723,GO:0005515,GO:0005829,GO:0006446,GO:0008494,GO:0045727,GO:0048471" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein binding|cytosol|regulation of translational initiation|translation activator activity|positive regulation of translation|perinuclear region of cytoplasm" CTNNA1 9243.947248 8972.21076 9515.683735 1.060572917 0.084843813 0.799807617 1 91.54126168 101.2682619 1495 catenin alpha 1 "GO:0001541,GO:0001669,GO:0003723,GO:0005198,GO:0005515,GO:0005829,GO:0005886,GO:0005911,GO:0005915,GO:0005925,GO:0007015,GO:0007155,GO:0007163,GO:0007406,GO:0007568,GO:0008013,GO:0008584,GO:0014704,GO:0015629,GO:0016264,GO:0016342,GO:0016600,GO:0017166,GO:0030027,GO:0030054,GO:0031103,GO:0034332,GO:0034613,GO:0042475,GO:0042802,GO:0043231,GO:0043297,GO:0043627,GO:0045295,GO:0045296,GO:0045880,GO:0051015,GO:0051149,GO:0071681,GO:0090136,GO:1900181,GO:2000146,GO:2001045,GO:2001240,GO:2001241" ovarian follicle development|acrosomal vesicle|RNA binding|structural molecule activity|protein binding|cytosol|plasma membrane|cell-cell junction|zonula adherens|focal adhesion|actin filament organization|cell adhesion|establishment or maintenance of cell polarity|negative regulation of neuroblast proliferation|aging|beta-catenin binding|male gonad development|intercalated disc|actin cytoskeleton|gap junction assembly|catenin complex|flotillin complex|vinculin binding|lamellipodium|cell junction|axon regeneration|adherens junction organization|cellular protein localization|odontogenesis of dentin-containing tooth|identical protein binding|intracellular membrane-bounded organelle|apical junction assembly|response to estrogen|gamma-catenin binding|cadherin binding|positive regulation of smoothened signaling pathway|actin filament binding|positive regulation of muscle cell differentiation|cellular response to indole-3-methanol|epithelial cell-cell adhesion|negative regulation of protein localization to nucleus|negative regulation of cell motility|negative regulation of integrin-mediated signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04390,hsa04520,hsa04670,hsa05100,hsa05200,hsa05213,hsa05226,hsa05412" Hippo signaling pathway|Adherens junction|Leukocyte transendothelial migration|Bacterial invasion of epithelial cells|Pathways in cancer|Endometrial cancer|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy CTNNAL1 2165.991742 2114.153282 2217.830202 1.049039453 0.069068936 0.830613864 1 42.86405342 46.90303963 8727 catenin alpha like 1 "GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0007155,GO:0007266,GO:0045296,GO:0051015" protein binding|cytosol|cytoskeleton|plasma membrane|cell adhesion|Rho protein signal transduction|cadherin binding|actin filament binding CTNNB1 16696.34703 16944.68989 16448.00417 0.970687825 -0.042920699 0.90388891 1 215.517018 218.211222 1499 catenin beta 1 "GO:0000209,GO:0000791,GO:0000922,GO:0001085,GO:0001102,GO:0001569,GO:0001837,GO:0002052,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0005925,GO:0005938,GO:0007155,GO:0007223,GO:0008013,GO:0008022,GO:0008134,GO:0008285,GO:0010718,GO:0010909,GO:0016020,GO:0016032,GO:0016055,GO:0016323,GO:0016328,GO:0016342,GO:0016525,GO:0019827,GO:0019899,GO:0019900,GO:0019903,GO:0030054,GO:0030331,GO:0030877,GO:0030997,GO:0032355,GO:0032481,GO:0032991,GO:0032993,GO:0033234,GO:0034333,GO:0034394,GO:0035257,GO:0035315,GO:0035635,GO:0035995,GO:0036023,GO:0042493,GO:0042995,GO:0043065,GO:0043066,GO:0043161,GO:0043525,GO:0044325,GO:0044334,GO:0044336,GO:0045202,GO:0045294,GO:0045296,GO:0045765,GO:0045892,GO:0045893,GO:0045944,GO:0045976,GO:0046332,GO:0048145,GO:0048471,GO:0048660,GO:0050767,GO:0051091,GO:0051149,GO:0051571,GO:0060070,GO:0060828,GO:0061154,GO:0061324,GO:0061549,GO:0070062,GO:0070369,GO:0070411,GO:0070602,GO:0071363,GO:0071681,GO:0071944,GO:0072182,GO:0090279,GO:0098609,GO:1904798,GO:1904837,GO:1904886,GO:1904948,GO:1904954,GO:1990138,GO:1990907,GO:1990909,GO:2000008,GO:2000144" "protein polyubiquitination|euchromatin|spindle pole|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|branching involved in blood vessel morphogenesis|epithelial to mesenchymal transition|positive regulation of neuroblast proliferation|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|centrosome|cytosol|plasma membrane|cell-cell junction|adherens junction|focal adhesion|cell cortex|cell adhesion|Wnt signaling pathway, calcium modulating pathway|beta-catenin binding|protein C-terminus binding|transcription factor binding|negative regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of heparan sulfate proteoglycan biosynthetic process|membrane|viral process|Wnt signaling pathway|basolateral plasma membrane|lateral plasma membrane|catenin complex|negative regulation of angiogenesis|stem cell population maintenance|enzyme binding|kinase binding|protein phosphatase binding|cell junction|estrogen receptor binding|beta-catenin destruction complex|regulation of centriole-centriole cohesion|response to estradiol|positive regulation of type I interferon production|protein-containing complex|protein-DNA complex|negative regulation of protein sumoylation|adherens junction assembly|protein localization to cell surface|nuclear hormone receptor binding|hair cell differentiation|entry of bacterium into host cell|detection of muscle stretch|embryonic skeletal limb joint morphogenesis|response to drug|cell projection|positive regulation of apoptotic process|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of neuron apoptotic process|ion channel binding|canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|synapse|alpha-catenin binding|cadherin binding|regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of mitotic cell cycle, embryonic|SMAD binding|regulation of fibroblast proliferation|perinuclear region of cytoplasm|regulation of smooth muscle cell proliferation|regulation of neurogenesis|positive regulation of DNA-binding transcription factor activity|positive regulation of muscle cell differentiation|positive regulation of histone H3-K4 methylation|canonical Wnt signaling pathway|regulation of canonical Wnt signaling pathway|endothelial tube morphogenesis|canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation|sympathetic ganglion development|extracellular exosome|beta-catenin-TCF7L2 complex|I-SMAD binding|regulation of centromeric sister chromatid cohesion|cellular response to growth factor stimulus|cellular response to indole-3-methanol|cell periphery|regulation of nephron tubule epithelial cell differentiation|regulation of calcium ion import|cell-cell adhesion|positive regulation of core promoter binding|beta-catenin-TCF complex assembly|beta-catenin destruction complex disassembly|midbrain dopaminergic neuron differentiation|canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|neuron projection extension|beta-catenin-TCF complex|Wnt signalosome|regulation of protein localization to cell surface|positive regulation of DNA-templated transcription, initiation" "hsa04015,hsa04310,hsa04390,hsa04510,hsa04520,hsa04550,hsa04670,hsa04916,hsa04919,hsa04934,hsa05010,hsa05022,hsa05100,hsa05132,hsa05160,hsa05163,hsa05165,hsa05167,hsa05200,hsa05205,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05224,hsa05225,hsa05226,hsa05412,hsa05418" Rap1 signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Focal adhesion|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Leukocyte transendothelial migration|Melanogenesis|Thyroid hormone signaling pathway|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Bacterial invasion of epithelial cells|Salmonella infection|Hepatitis C|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy|Fluid shear stress and atherosclerosis other CTNNBIP1 502.2658791 490.2237327 514.3080254 1.049129186 0.069192336 0.869868146 1 7.310984292 8.000566683 56998 catenin beta interacting protein 1 "GO:0001658,GO:0002528,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008013,GO:0009952,GO:0016055,GO:0030178,GO:0030877,GO:0031333,GO:0032091,GO:0043392,GO:0043433,GO:0045657,GO:0045669,GO:0048662,GO:0060633,GO:0070016,GO:0072201" branching involved in ureteric bud morphogenesis|regulation of vascular permeability involved in acute inflammatory response|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|beta-catenin binding|anterior/posterior pattern specification|Wnt signaling pathway|negative regulation of Wnt signaling pathway|beta-catenin destruction complex|negative regulation of protein-containing complex assembly|negative regulation of protein binding|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|positive regulation of monocyte differentiation|positive regulation of osteoblast differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription initiation from RNA polymerase II promoter|armadillo repeat domain binding|negative regulation of mesenchymal cell proliferation hsa04310 Wnt signaling pathway CTNNBL1 1366.340796 1433.117827 1299.563765 0.906808736 -0.141129805 0.675222163 1 32.91717107 31.13537707 56259 catenin beta like 1 "GO:0000398,GO:0000974,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005813,GO:0005829,GO:0006915,GO:0016020,GO:0016445,GO:0019899,GO:0043065" "mRNA splicing, via spliceosome|Prp19 complex|protein binding|nucleus|nucleoplasm|spliceosomal complex|centrosome|cytosol|apoptotic process|membrane|somatic diversification of immunoglobulins|enzyme binding|positive regulation of apoptotic process" hsa03040 Spliceosome CTNND1 5295.480786 5535.569852 5055.391721 0.913255881 -0.130908956 0.684578402 1 42.49766328 40.48307177 1500 catenin delta 1 "GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0005915,GO:0007043,GO:0007420,GO:0016055,GO:0016342,GO:0019901,GO:0030027,GO:0030426,GO:0030496,GO:0034332,GO:0035635,GO:0043197,GO:0044331,GO:0045296,GO:0050821,GO:0070062,GO:0090090,GO:0098609,GO:0098685,GO:0098686,GO:0098831,GO:0098978,GO:0099072,GO:0099092" "signaling receptor binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|cell-cell junction|adherens junction|zonula adherens|cell-cell junction assembly|brain development|Wnt signaling pathway|catenin complex|protein kinase binding|lamellipodium|growth cone|midbody|adherens junction organization|entry of bacterium into host cell|dendritic spine|cell-cell adhesion mediated by cadherin|cadherin binding|protein stabilization|extracellular exosome|negative regulation of canonical Wnt signaling pathway|cell-cell adhesion|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|presynaptic active zone cytoplasmic component|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels|postsynaptic density, intracellular component" "hsa04015,hsa04520,hsa04670" Rap1 signaling pathway|Adherens junction|Leukocyte transendothelial migration CTNS 568.7036793 586.6445497 550.7628088 0.938835636 -0.091055491 0.821771477 1 6.608424574 6.471477316 1497 "cystinosin, lysosomal cystine transporter" "GO:0002088,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005774,GO:0005886,GO:0006520,GO:0006749,GO:0006811,GO:0007420,GO:0007616,GO:0007625,GO:0007628,GO:0008542,GO:0010730,GO:0010918,GO:0015184,GO:0015811,GO:0016021,GO:0042438,GO:0042470,GO:0043231,GO:0045111,GO:0046034,GO:0050890,GO:0055085,GO:0070062" lens development in camera-type eye|lysosome|lysosomal membrane|early endosome|late endosome|vacuolar membrane|plasma membrane|cellular amino acid metabolic process|glutathione metabolic process|ion transport|brain development|long-term memory|grooming behavior|adult walking behavior|visual learning|negative regulation of hydrogen peroxide biosynthetic process|positive regulation of mitochondrial membrane potential|L-cystine transmembrane transporter activity|L-cystine transport|integral component of membrane|melanin biosynthetic process|melanosome|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|ATP metabolic process|cognition|transmembrane transport|extracellular exosome hsa04142 Lysosome CTPS1 1701.724607 1729.48497 1673.964244 0.967897538 -0.047073764 0.887127839 1 21.46870404 21.67460261 1503 CTP synthase 1 "GO:0003883,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006139,GO:0006241,GO:0006541,GO:0015949,GO:0016020,GO:0019856,GO:0042098,GO:0042100,GO:0042493,GO:0042802,GO:0044210,GO:0097268" CTP synthase activity|protein binding|ATP binding|cytoplasm|cytosol|nucleobase-containing compound metabolic process|CTP biosynthetic process|glutamine metabolic process|nucleobase-containing small molecule interconversion|membrane|pyrimidine nucleobase biosynthetic process|T cell proliferation|B cell proliferation|response to drug|identical protein binding|'de novo' CTP biosynthetic process|cytoophidium hsa00240 Pyrimidine metabolism CTPS2 674.6614198 623.1829646 726.139875 1.165211369 0.220591682 0.563739205 1 6.203226945 7.539426524 56474 CTP synthase 2 "GO:0003883,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006220,GO:0006241,GO:0006541,GO:0015949,GO:0019856,GO:0042802,GO:0044210,GO:0097268" CTP synthase activity|protein binding|ATP binding|cytoplasm|cytosol|pyrimidine nucleotide metabolic process|CTP biosynthetic process|glutamine metabolic process|nucleobase-containing small molecule interconversion|pyrimidine nucleobase biosynthetic process|identical protein binding|'de novo' CTP biosynthetic process|cytoophidium hsa00240 Pyrimidine metabolism CTR9 1286.522254 1398.609324 1174.435185 0.839716398 -0.252025933 0.456932854 1 16.35903656 14.3286834 9646 "CTR9 homolog, Paf1/RNA polymerase II complex component" "GO:0000122,GO:0000993,GO:0001711,GO:0001826,GO:0001829,GO:0001832,GO:0001835,GO:0005515,GO:0005654,GO:0006355,GO:0006366,GO:0006368,GO:0007259,GO:0010390,GO:0016055,GO:0016567,GO:0016593,GO:0016607,GO:0019827,GO:0033523,GO:0035327,GO:0042169,GO:0045638,GO:0051569,GO:0051571,GO:0070102,GO:0071222,GO:0080182,GO:1900364,GO:2000653,GO:2001162,GO:2001168" "negative regulation of transcription by RNA polymerase II|RNA polymerase II complex binding|endodermal cell fate commitment|inner cell mass cell differentiation|trophectodermal cell differentiation|blastocyst growth|blastocyst hatching|protein binding|nucleoplasm|regulation of transcription, DNA-templated|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|receptor signaling pathway via JAK-STAT|histone monoubiquitination|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|nuclear speck|stem cell population maintenance|histone H2B ubiquitination|transcriptionally active chromatin|SH2 domain binding|negative regulation of myeloid cell differentiation|regulation of histone H3-K4 methylation|positive regulation of histone H3-K4 methylation|interleukin-6-mediated signaling pathway|cellular response to lipopolysaccharide|histone H3-K4 trimethylation|negative regulation of mRNA polyadenylation|regulation of genetic imprinting|positive regulation of histone H3-K79 methylation|positive regulation of histone H2B ubiquitination" CTRL 7.508249331 8.119647747 6.896850916 0.849402724 -0.235479359 0.974243744 1 0.352988424 0.31274476 1506 chymotrypsin like "GO:0004252,GO:0005515,GO:0005615,GO:0006508,GO:0008236,GO:0030163" serine-type endopeptidase activity|protein binding|extracellular space|proteolysis|serine-type peptidase activity|protein catabolic process "hsa04972,hsa04974" Pancreatic secretion|Protein digestion and absorption CTSA 10434.5433 11255.86169 9613.224912 0.85406388 -0.227584113 0.500442545 1 186.9693953 166.5623381 5476 cathepsin A "GO:0004180,GO:0004185,GO:0005576,GO:0005764,GO:0005783,GO:0006508,GO:0006687,GO:0006886,GO:0008047,GO:0016020,GO:0031647,GO:0035578,GO:0043202,GO:0043231,GO:0043312,GO:0050790,GO:0070062,GO:0098575,GO:1904714,GO:1904715" carboxypeptidase activity|serine-type carboxypeptidase activity|extracellular region|lysosome|endoplasmic reticulum|proteolysis|glycosphingolipid metabolic process|intracellular protein transport|enzyme activator activity|membrane|regulation of protein stability|azurophil granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of catalytic activity|extracellular exosome|lumenal side of lysosomal membrane|regulation of chaperone-mediated autophagy|negative regulation of chaperone-mediated autophagy "hsa04142,hsa04614" Lysosome|Renin-angiotensin system CTSB 15817.28927 16122.57556 15512.00297 0.96212934 -0.055697246 0.874609637 1 165.7972741 166.3898285 1508 cathepsin B "GO:0002224,GO:0004197,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005622,GO:0005764,GO:0006508,GO:0008233,GO:0008234,GO:0016324,GO:0030574,GO:0030855,GO:0036021,GO:0042470,GO:0042981,GO:0043312,GO:0043394,GO:0048471,GO:0050790,GO:0051603,GO:0062023,GO:0070062,GO:0097067,GO:1904813" toll-like receptor signaling pathway|cysteine-type endopeptidase activity|protein binding|collagen binding|extracellular region|extracellular space|intracellular anatomical structure|lysosome|proteolysis|peptidase activity|cysteine-type peptidase activity|apical plasma membrane|collagen catabolic process|epithelial cell differentiation|endolysosome lumen|melanosome|regulation of apoptotic process|neutrophil degranulation|proteoglycan binding|perinuclear region of cytoplasm|regulation of catalytic activity|proteolysis involved in cellular protein catabolic process|collagen-containing extracellular matrix|extracellular exosome|cellular response to thyroid hormone stimulus|ficolin-1-rich granule lumen "hsa04140,hsa04142,hsa04210,hsa04612,hsa04621,hsa04924" Autophagy - animal|Lysosome|Apoptosis|Antigen processing and presentation|NOD-like receptor signaling pathway|Renin secretion CTSC 3735.678301 4550.047606 2921.308995 0.642039215 -0.639266676 0.045243115 0.96408227 30.36951234 20.33833064 1075 cathepsin C "GO:0000139,GO:0001913,GO:0004197,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005654,GO:0005764,GO:0005788,GO:0005813,GO:0006508,GO:0006888,GO:0006915,GO:0006955,GO:0007568,GO:0008234,GO:0008239,GO:0010033,GO:0016020,GO:0016505,GO:0019902,GO:0030134,GO:0031404,GO:0031642,GO:0033116,GO:0035578,GO:0042802,GO:0043231,GO:0043312,GO:0043621,GO:0048208,GO:0051087,GO:0051603,GO:0062023,GO:0070062,GO:1903052,GO:1903980,GO:2001235" Golgi membrane|T cell mediated cytotoxicity|cysteine-type endopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|nucleoplasm|lysosome|endoplasmic reticulum lumen|centrosome|proteolysis|endoplasmic reticulum to Golgi vesicle-mediated transport|apoptotic process|immune response|aging|cysteine-type peptidase activity|dipeptidyl-peptidase activity|response to organic substance|membrane|peptidase activator activity involved in apoptotic process|phosphatase binding|COPII-coated ER to Golgi transport vesicle|chloride ion binding|negative regulation of myelination|endoplasmic reticulum-Golgi intermediate compartment membrane|azurophil granule lumen|identical protein binding|intracellular membrane-bounded organelle|neutrophil degranulation|protein self-association|COPII vesicle coating|chaperone binding|proteolysis involved in cellular protein catabolic process|collagen-containing extracellular matrix|extracellular exosome|positive regulation of proteolysis involved in cellular protein catabolic process|positive regulation of microglial cell activation|positive regulation of apoptotic signaling pathway "hsa04142,hsa04210" Lysosome|Apoptosis CTSD 7273.849188 8631.185555 5916.512821 0.685480898 -0.544811632 0.097811477 1 212.7197564 152.0964626 1509 cathepsin D "GO:0004190,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005765,GO:0006508,GO:0008233,GO:0010008,GO:0019886,GO:0030574,GO:0035580,GO:0042159,GO:0042470,GO:0043065,GO:0043202,GO:0043280,GO:0043312,GO:0045121,GO:0062023,GO:0070001,GO:0070062,GO:0070201,GO:1904724,GO:1904813" aspartic-type endopeptidase activity|protein binding|extracellular region|extracellular space|lysosome|lysosomal membrane|proteolysis|peptidase activity|endosome membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|collagen catabolic process|specific granule lumen|lipoprotein catabolic process|melanosome|positive regulation of apoptotic process|lysosomal lumen|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|membrane raft|collagen-containing extracellular matrix|aspartic-type peptidase activity|extracellular exosome|regulation of establishment of protein localization|tertiary granule lumen|ficolin-1-rich granule lumen "hsa04071,hsa04140,hsa04142,hsa04210,hsa04915,hsa05152" Sphingolipid signaling pathway|Autophagy - animal|Lysosome|Apoptosis|Estrogen signaling pathway|Tuberculosis CTSF 570.9347511 503.4181603 638.4513419 1.268232639 0.342819411 0.386717045 1 12.15269488 16.0763499 8722 cathepsin F "GO:0004197,GO:0005615,GO:0005764,GO:0006508,GO:0019886,GO:0043202,GO:0051603,GO:0062023,GO:0070062,GO:1903561" cysteine-type endopeptidase activity|extracellular space|lysosome|proteolysis|antigen processing and presentation of exogenous peptide antigen via MHC class II|lysosomal lumen|proteolysis involved in cellular protein catabolic process|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle "hsa04142,hsa04210" Lysosome|Apoptosis CTSH 190.1842401 204.0061496 176.3623306 0.864495168 -0.210070195 0.70741064 1 3.622788145 3.266791656 1512 cathepsin H "GO:0001656,GO:0001913,GO:0002250,GO:0002764,GO:0004175,GO:0004177,GO:0004197,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005829,GO:0006508,GO:0006919,GO:0008233,GO:0008234,GO:0008284,GO:0008656,GO:0010628,GO:0010634,GO:0010813,GO:0010815,GO:0010952,GO:0019882,GO:0030108,GO:0030335,GO:0031638,GO:0031648,GO:0032526,GO:0033619,GO:0034774,GO:0036464,GO:0043066,GO:0043129,GO:0043231,GO:0043312,GO:0044267,GO:0045766,GO:0051603,GO:0060448,GO:0062023,GO:0070062,GO:0070324,GO:0070371,GO:0097067,GO:0097208,GO:0097486,GO:1904724,GO:1904813" metanephros development|T cell mediated cytotoxicity|adaptive immune response|immune response-regulating signaling pathway|endopeptidase activity|aminopeptidase activity|cysteine-type endopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|lysosome|cytosol|proteolysis|activation of cysteine-type endopeptidase activity involved in apoptotic process|peptidase activity|cysteine-type peptidase activity|positive regulation of cell population proliferation|cysteine-type endopeptidase activator activity involved in apoptotic process|positive regulation of gene expression|positive regulation of epithelial cell migration|neuropeptide catabolic process|bradykinin catabolic process|positive regulation of peptidase activity|antigen processing and presentation|HLA-A specific activating MHC class I receptor activity|positive regulation of cell migration|zymogen activation|protein destabilization|response to retinoic acid|membrane protein proteolysis|secretory granule lumen|cytoplasmic ribonucleoprotein granule|negative regulation of apoptotic process|surfactant homeostasis|intracellular membrane-bounded organelle|neutrophil degranulation|cellular protein metabolic process|positive regulation of angiogenesis|proteolysis involved in cellular protein catabolic process|dichotomous subdivision of terminal units involved in lung branching|collagen-containing extracellular matrix|extracellular exosome|thyroid hormone binding|ERK1 and ERK2 cascade|cellular response to thyroid hormone stimulus|alveolar lamellar body|multivesicular body lumen|tertiary granule lumen|ficolin-1-rich granule lumen "hsa04142,hsa04210" Lysosome|Apoptosis CTSK 106.9699749 72.06187375 141.878076 1.968836898 0.977343601 0.141722447 1 2.240441797 4.601075245 1513 cathepsin K "GO:0000422,GO:0001968,GO:0002224,GO:0004197,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005654,GO:0005764,GO:0006508,GO:0006590,GO:0006955,GO:0008234,GO:0016324,GO:0022617,GO:0030574,GO:0036021,GO:0043202,GO:0043231,GO:0043394,GO:0045616,GO:0051603" autophagy of mitochondrion|fibronectin binding|toll-like receptor signaling pathway|cysteine-type endopeptidase activity|protein binding|collagen binding|extracellular region|extracellular space|nucleoplasm|lysosome|proteolysis|thyroid hormone generation|immune response|cysteine-type peptidase activity|apical plasma membrane|extracellular matrix disassembly|collagen catabolic process|endolysosome lumen|lysosomal lumen|intracellular membrane-bounded organelle|proteoglycan binding|regulation of keratinocyte differentiation|proteolysis involved in cellular protein catabolic process "hsa04142,hsa04210,hsa04380,hsa04620,hsa05323" Lysosome|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|Rheumatoid arthritis CTSL 2640.371818 2786.054133 2494.689503 0.895420327 -0.159363026 0.617447911 1 87.47911546 81.70474179 1514 cathepsin L "GO:0001968,GO:0002224,GO:0002250,GO:0004197,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005634,GO:0005764,GO:0005771,GO:0005794,GO:0005886,GO:0006508,GO:0006955,GO:0008234,GO:0016324,GO:0016540,GO:0019064,GO:0019065,GO:0019882,GO:0019886,GO:0022617,GO:0030574,GO:0031638,GO:0034230,GO:0036021,GO:0039654,GO:0042393,GO:0042583,GO:0043202,GO:0043231,GO:0043373,GO:0043394,GO:0045616,GO:0046718,GO:0048002,GO:0051603,GO:0060309,GO:0062023,GO:0070062,GO:0071888,GO:0097067,GO:0097655" "fibronectin binding|toll-like receptor signaling pathway|adaptive immune response|cysteine-type endopeptidase activity|protein binding|collagen binding|extracellular region|extracellular space|nucleus|lysosome|multivesicular body|Golgi apparatus|plasma membrane|proteolysis|immune response|cysteine-type peptidase activity|apical plasma membrane|protein autoprocessing|fusion of virus membrane with host plasma membrane|receptor-mediated endocytosis of virus by host cell|antigen processing and presentation|antigen processing and presentation of exogenous peptide antigen via MHC class II|extracellular matrix disassembly|collagen catabolic process|zymogen activation|enkephalin processing|endolysosome lumen|fusion of virus membrane with host endosome membrane|histone binding|chromaffin granule|lysosomal lumen|intracellular membrane-bounded organelle|CD4-positive, alpha-beta T cell lineage commitment|proteoglycan binding|regulation of keratinocyte differentiation|viral entry into host cell|antigen processing and presentation of peptide antigen|proteolysis involved in cellular protein catabolic process|elastin catabolic process|collagen-containing extracellular matrix|extracellular exosome|macrophage apoptotic process|cellular response to thyroid hormone stimulus|serpin family protein binding" "hsa04140,hsa04142,hsa04145,hsa04210,hsa04612,hsa05205,hsa05323,hsa05418" Autophagy - animal|Lysosome|Phagosome|Apoptosis|Antigen processing and presentation|Proteoglycans in cancer|Rheumatoid arthritis|Fluid shear stress and atherosclerosis CTSO 138.9586553 103.5255088 174.3918017 1.684529772 0.752345927 0.216497928 1 1.806132209 3.173541328 1519 cathepsin O "GO:0004197,GO:0005515,GO:0005615,GO:0005764,GO:0006508,GO:0051603" cysteine-type endopeptidase activity|protein binding|extracellular space|lysosome|proteolysis|proteolysis involved in cellular protein catabolic process "hsa04142,hsa04210" Lysosome|Apoptosis CTSS 1871.517931 1920.296692 1822.739171 0.949196641 -0.075221099 0.817637602 1 24.70941389 24.46439986 1520 cathepsin S "GO:0001968,GO:0002224,GO:0002250,GO:0004197,GO:0005518,GO:0005576,GO:0005615,GO:0005764,GO:0005770,GO:0006508,GO:0006955,GO:0010447,GO:0016485,GO:0019882,GO:0019886,GO:0022617,GO:0030574,GO:0034769,GO:0036021,GO:0043202,GO:0043231,GO:0043236,GO:0043312,GO:0043394,GO:0045335,GO:0048002,GO:0051603,GO:0062023,GO:0097067,GO:1904724,GO:1904813,GO:2001259" fibronectin binding|toll-like receptor signaling pathway|adaptive immune response|cysteine-type endopeptidase activity|collagen binding|extracellular region|extracellular space|lysosome|late endosome|proteolysis|immune response|response to acidic pH|protein processing|antigen processing and presentation|antigen processing and presentation of exogenous peptide antigen via MHC class II|extracellular matrix disassembly|collagen catabolic process|basement membrane disassembly|endolysosome lumen|lysosomal lumen|intracellular membrane-bounded organelle|laminin binding|neutrophil degranulation|proteoglycan binding|phagocytic vesicle|antigen processing and presentation of peptide antigen|proteolysis involved in cellular protein catabolic process|collagen-containing extracellular matrix|cellular response to thyroid hormone stimulus|tertiary granule lumen|ficolin-1-rich granule lumen|positive regulation of cation channel activity "hsa04142,hsa04145,hsa04210,hsa04612,hsa05152" Lysosome|Phagosome|Apoptosis|Antigen processing and presentation|Tuberculosis CTSV 394.05554 434.4011545 353.7099255 0.814247204 -0.296461234 0.497632309 1 5.004751137 4.250643601 1515 cathepsin V "GO:0004197,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0006955,GO:0008234,GO:0019886,GO:0022617,GO:0043202,GO:0045616,GO:0051603" cysteine-type endopeptidase activity|protein binding|extracellular region|extracellular space|lysosome|immune response|cysteine-type peptidase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|extracellular matrix disassembly|lysosomal lumen|regulation of keratinocyte differentiation|proteolysis involved in cellular protein catabolic process "hsa04142,hsa04210" Lysosome|Apoptosis CTSW 18.71730231 33.49354696 3.941057666 0.117666178 -3.087228401 0.014078402 0.52712337 1.333592764 0.163678188 1521 cathepsin W "GO:0002576,GO:0004197,GO:0005576,GO:0005615,GO:0005764,GO:0005783,GO:0006955,GO:0008234,GO:0016020,GO:0031089,GO:0051603" platelet degranulation|cysteine-type endopeptidase activity|extracellular region|extracellular space|lysosome|endoplasmic reticulum|immune response|cysteine-type peptidase activity|membrane|platelet dense granule lumen|proteolysis involved in cellular protein catabolic process "hsa04142,hsa04210" Lysosome|Apoptosis CTSZ 9513.506886 9887.701044 9139.312728 0.924311191 -0.113549444 0.734799295 1 333.4069082 321.446525 1522 cathepsin Z "GO:0000139,GO:0002003,GO:0004180,GO:0004197,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005783,GO:0005788,GO:0005886,GO:0006508,GO:0006888,GO:0008234,GO:0010757,GO:0030134,GO:0031410,GO:0032091,GO:0033116,GO:0035580,GO:0043312,GO:0048208,GO:0051603,GO:0062023,GO:0070062,GO:0099738,GO:1901214,GO:1904813" Golgi membrane|angiotensin maturation|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding|extracellular region|extracellular space|lysosome|endoplasmic reticulum|endoplasmic reticulum lumen|plasma membrane|proteolysis|endoplasmic reticulum to Golgi vesicle-mediated transport|cysteine-type peptidase activity|negative regulation of plasminogen activation|COPII-coated ER to Golgi transport vesicle|cytoplasmic vesicle|negative regulation of protein binding|endoplasmic reticulum-Golgi intermediate compartment membrane|specific granule lumen|neutrophil degranulation|COPII vesicle coating|proteolysis involved in cellular protein catabolic process|collagen-containing extracellular matrix|extracellular exosome|cell cortex region|regulation of neuron death|ficolin-1-rich granule lumen "hsa04142,hsa04210" Lysosome|Apoptosis CTTN 6075.036494 6055.227307 6094.845681 1.006542838 0.009408575 0.977429407 1 74.13002213 77.82915632 2017 cortactin "GO:0001726,GO:0002102,GO:0005515,GO:0005522,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005905,GO:0005925,GO:0005938,GO:0006886,GO:0006898,GO:0006930,GO:0008076,GO:0030027,GO:0030041,GO:0030426,GO:0030427,GO:0030516,GO:0030833,GO:0030838,GO:0030863,GO:0030864,GO:0031532,GO:0043197,GO:0043231,GO:0045296,GO:0045987,GO:0048041,GO:0048812,GO:0048870,GO:0051015,GO:0061024,GO:0097062,GO:0097581,GO:1903146,GO:1990023,GO:2001237" "ruffle|podosome|protein binding|profilin binding|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|actin filament|plasma membrane|clathrin-coated pit|focal adhesion|cell cortex|intracellular protein transport|receptor-mediated endocytosis|substrate-dependent cell migration, cell extension|voltage-gated potassium channel complex|lamellipodium|actin filament polymerization|growth cone|site of polarized growth|regulation of axon extension|regulation of actin filament polymerization|positive regulation of actin filament polymerization|cortical cytoskeleton|cortical actin cytoskeleton|actin cytoskeleton reorganization|dendritic spine|intracellular membrane-bounded organelle|cadherin binding|positive regulation of smooth muscle contraction|focal adhesion assembly|neuron projection morphogenesis|cell motility|actin filament binding|membrane organization|dendritic spine maintenance|lamellipodium organization|regulation of autophagy of mitochondrion|mitotic spindle midzone|negative regulation of extrinsic apoptotic signaling pathway" "hsa04530,hsa05100,hsa05130,hsa05131,hsa05205" Tight junction|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Proteoglycans in cancer CTTNBP2NL 1257.636587 1208.812558 1306.460616 1.080780149 0.112073081 0.742926099 1 10.32587142 11.64072425 55917 CTTNBP2 N-terminal like "GO:0005515,GO:0005737,GO:0006470,GO:0015629,GO:0030027,GO:0032410,GO:0034763,GO:0051721" protein binding|cytoplasm|protein dephosphorylation|actin cytoskeleton|lamellipodium|negative regulation of transporter activity|negative regulation of transmembrane transport|protein phosphatase 2A binding CTU1 85.09844101 92.36099312 77.83588891 0.842735513 -0.246848173 0.741119515 1 2.200262687 1.934112621 90353 cytosolic thiouridylase subunit 1 "GO:0000049,GO:0002098,GO:0002143,GO:0002144,GO:0005515,GO:0005829,GO:0006400,GO:0016779,GO:0032447,GO:0034227" tRNA binding|tRNA wobble uridine modification|tRNA wobble position uridine thiolation|cytosolic tRNA wobble base thiouridylase complex|protein binding|cytosol|tRNA modification|nucleotidyltransferase activity|protein urmylation|tRNA thio-modification hsa04122 Sulfur relay system CTU2 228.2775021 248.6642123 207.8907919 0.836030203 -0.258373032 0.620789101 1 6.438632472 5.614764337 348180 cytosolic thiouridylase subunit 2 "GO:0000049,GO:0002098,GO:0002143,GO:0005515,GO:0005829,GO:0006400,GO:0016779,GO:0016783,GO:0032447,GO:0032991,GO:0034227" tRNA binding|tRNA wobble uridine modification|tRNA wobble position uridine thiolation|protein binding|cytosol|tRNA modification|nucleotidyltransferase activity|sulfurtransferase activity|protein urmylation|protein-containing complex|tRNA thio-modification hsa04122 Sulfur relay system CTXN1 193.8971679 255.768904 132.0254318 0.516190318 -0.954025014 0.080736031 1 10.47194235 5.638362924 404217 cortexin 1 GO:0016021 integral component of membrane CUBN 22.71774308 37.55337083 7.882115332 0.209891021 -2.252287647 0.043880709 0.952191822 0.13409093 0.029356832 8029 cubilin "GO:0001894,GO:0005509,GO:0005515,GO:0005765,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005905,GO:0006898,GO:0008203,GO:0009235,GO:0009617,GO:0010008,GO:0015889,GO:0016020,GO:0016324,GO:0030139,GO:0031232,GO:0031419,GO:0031526,GO:0034384,GO:0038023,GO:0038024,GO:0042359,GO:0042803,GO:0042953,GO:0043202,GO:0043235,GO:0070062" tissue homeostasis|calcium ion binding|protein binding|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|clathrin-coated pit|receptor-mediated endocytosis|cholesterol metabolic process|cobalamin metabolic process|response to bacterium|endosome membrane|cobalamin transport|membrane|apical plasma membrane|endocytic vesicle|extrinsic component of external side of plasma membrane|cobalamin binding|brush border membrane|high-density lipoprotein particle clearance|signaling receptor activity|cargo receptor activity|vitamin D metabolic process|protein homodimerization activity|lipoprotein transport|lysosomal lumen|receptor complex|extracellular exosome hsa04977 Vitamin digestion and absorption CUEDC1 890.1911053 1044.389691 735.9925192 0.704710632 -0.504897115 0.160789798 1 12.92951686 9.504057392 404093 CUE domain containing 1 "GO:0005515,GO:0043130" protein binding|ubiquitin binding CUEDC2 2339.931243 2352.667935 2327.194552 0.989172555 -0.015705883 0.962241936 1 108.3221193 111.7648233 79004 CUE domain containing 2 "GO:0005515,GO:0005654,GO:0005829,GO:0010936,GO:0031965,GO:0043130,GO:1900016" protein binding|nucleoplasm|cytosol|negative regulation of macrophage cytokine production|nuclear membrane|ubiquitin binding|negative regulation of cytokine production involved in inflammatory response CUL1 1918.273454 1917.251824 1919.295083 1.001065723 0.001536694 0.998058341 1 22.48773535 23.48141383 8454 cullin 1 "GO:0000082,GO:0000086,GO:0000209,GO:0002223,GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006513,GO:0006879,GO:0008283,GO:0009887,GO:0010265,GO:0010972,GO:0016032,GO:0016055,GO:0016567,GO:0019005,GO:0031146,GO:0031461,GO:0031625,GO:0038061,GO:0038095,GO:0043687,GO:0050852,GO:0051403,GO:0070498,GO:0070936,GO:0097193,GO:1901990,GO:1990452" G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|plasma membrane|protein monoubiquitination|cellular iron ion homeostasis|cell population proliferation|animal organ morphogenesis|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|viral process|Wnt signaling pathway|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|ubiquitin protein ligase binding|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|post-translational protein modification|T cell receptor signaling pathway|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|protein K48-linked ubiquitination|intrinsic apoptotic signaling pathway|regulation of mitotic cell cycle phase transition|Parkin-FBXW7-Cul1 ubiquitin ligase complex "hsa04110,hsa04114,hsa04120,hsa04141,hsa04310,hsa04340,hsa04350,hsa04710,hsa05131,hsa05170,hsa05200" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Wnt signaling pathway|Hedgehog signaling pathway|TGF-beta signaling pathway|Circadian rhythm|Shigellosis|Human immunodeficiency virus 1 infection|Pathways in cancer CUL2 1637.833599 1706.140983 1569.526216 0.919927621 -0.120407739 0.71472749 1 16.52831329 15.85981528 8453 cullin 2 "GO:0000082,GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0016032,GO:0016567,GO:0019005,GO:0030891,GO:0031146,GO:0031461,GO:0031462,GO:0031625,GO:0043687,GO:0044877,GO:0061418,GO:0097193" G1/S transition of mitotic cell cycle|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|viral process|protein ubiquitination|SCF ubiquitin ligase complex|VCB complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|Cul2-RING ubiquitin ligase complex|ubiquitin protein ligase binding|post-translational protein modification|protein-containing complex binding|regulation of transcription from RNA polymerase II promoter in response to hypoxia|intrinsic apoptotic signaling pathway "hsa04066,hsa04120,hsa05200,hsa05211" HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Pathways in cancer|Renal cell carcinoma CUL3 1415.197738 1472.70111 1357.694366 0.921907614 -0.117305913 0.726724994 1 10.22862258 9.836044513 8452 cullin 3 "GO:0000082,GO:0000122,GO:0000139,GO:0000165,GO:0000209,GO:0000922,GO:0001831,GO:0004842,GO:0005112,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005827,GO:0005829,GO:0005886,GO:0006511,GO:0006513,GO:0006888,GO:0007080,GO:0007229,GO:0007369,GO:0008284,GO:0016020,GO:0016055,GO:0016477,GO:0016567,GO:0017145,GO:0030030,GO:0030332,GO:0031145,GO:0031208,GO:0031398,GO:0031461,GO:0031463,GO:0031625,GO:0031648,GO:0032467,GO:0035024,GO:0036126,GO:0040016,GO:0043149,GO:0043161,GO:0043687,GO:0044346,GO:0045842,GO:0048208,GO:0051865,GO:0061630,GO:0070062,GO:0071630,GO:0072576,GO:0072686,GO:0090090,GO:0097193,GO:1901992" G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|Golgi membrane|MAPK cascade|protein polyubiquitination|spindle pole|trophectodermal cellular morphogenesis|ubiquitin-protein transferase activity|Notch binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|polar microtubule|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|protein monoubiquitination|endoplasmic reticulum to Golgi vesicle-mediated transport|mitotic metaphase plate congression|integrin-mediated signaling pathway|gastrulation|positive regulation of cell population proliferation|membrane|Wnt signaling pathway|cell migration|protein ubiquitination|stem cell division|cell projection organization|cyclin binding|anaphase-promoting complex-dependent catabolic process|POZ domain binding|positive regulation of protein ubiquitination|cullin-RING ubiquitin ligase complex|Cul3-RING ubiquitin ligase complex|ubiquitin protein ligase binding|protein destabilization|positive regulation of cytokinesis|negative regulation of Rho protein signal transduction|sperm flagellum|embryonic cleavage|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|fibroblast apoptotic process|positive regulation of mitotic metaphase/anaphase transition|COPII vesicle coating|protein autoubiquitination|ubiquitin protein ligase activity|extracellular exosome|nuclear protein quality control by the ubiquitin-proteasome system|liver morphogenesis|mitotic spindle|negative regulation of canonical Wnt signaling pathway|intrinsic apoptotic signaling pathway|positive regulation of mitotic cell cycle phase transition "hsa04120,hsa04340" Ubiquitin mediated proteolysis|Hedgehog signaling pathway CUL4A 1776.519587 1858.384378 1694.654796 0.911896816 -0.133057507 0.68350777 1 16.48058357 15.67596245 8451 cullin 4A "GO:0000082,GO:0000715,GO:0000717,GO:0001701,GO:0004842,GO:0005515,GO:0005654,GO:0006283,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006974,GO:0008284,GO:0016032,GO:0016567,GO:0019005,GO:0030097,GO:0030853,GO:0031146,GO:0031461,GO:0031464,GO:0031625,GO:0033683,GO:0035019,GO:0042254,GO:0042769,GO:0043161,GO:0043687,GO:0048511,GO:0051246,GO:0070911,GO:0080008,GO:0097193,GO:1900087,GO:2000001,GO:2000819" "G1/S transition of mitotic cell cycle|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|in utero embryonic development|ubiquitin-protein transferase activity|protein binding|nucleoplasm|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|cellular response to DNA damage stimulus|positive regulation of cell population proliferation|viral process|protein ubiquitination|SCF ubiquitin ligase complex|hemopoiesis|negative regulation of granulocyte differentiation|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|nucleotide-excision repair, DNA incision|somatic stem cell population maintenance|ribosome biogenesis|DNA damage response, detection of DNA damage|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|rhythmic process|regulation of protein metabolic process|global genome nucleotide-excision repair|Cul4-RING E3 ubiquitin ligase complex|intrinsic apoptotic signaling pathway|positive regulation of G1/S transition of mitotic cell cycle|regulation of DNA damage checkpoint|regulation of nucleotide-excision repair" "hsa03420,hsa04120,hsa05170" Nucleotide excision repair|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection CUL4B 2503.346081 2410.520425 2596.171738 1.077017108 0.107041167 0.737979204 1 19.30492658 21.68735988 8450 cullin 4B "GO:0000082,GO:0000715,GO:0000717,GO:0003684,GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0006283,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006974,GO:0010498,GO:0016567,GO:0019005,GO:0031146,GO:0031461,GO:0031465,GO:0031625,GO:0033683,GO:0035518,GO:0042254,GO:0042769,GO:0043687,GO:0070062,GO:0070911,GO:0070914,GO:0080008" "G1/S transition of mitotic cell cycle|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|damaged DNA binding|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|cellular response to DNA damage stimulus|proteasomal protein catabolic process|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|nucleotide-excision repair, DNA incision|histone H2A monoubiquitination|ribosome biogenesis|DNA damage response, detection of DNA damage|post-translational protein modification|extracellular exosome|global genome nucleotide-excision repair|UV-damage excision repair|Cul4-RING E3 ubiquitin ligase complex" "hsa03420,hsa04120,hsa05170" Nucleotide excision repair|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection CUL5 1242.444661 1146.900244 1337.989078 1.166613299 0.222326426 0.514079634 1 8.550927624 10.40533539 8065 cullin 5 "GO:0000082,GO:0004842,GO:0005262,GO:0005515,GO:0005829,GO:0016032,GO:0016567,GO:0019005,GO:0031146,GO:0031461,GO:0031466,GO:0031625,GO:0038023,GO:0038128,GO:0043687,GO:0070588,GO:0090734,GO:0097193" G1/S transition of mitotic cell cycle|ubiquitin-protein transferase activity|calcium channel activity|protein binding|cytosol|viral process|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|Cul5-RING ubiquitin ligase complex|ubiquitin protein ligase binding|signaling receptor activity|ERBB2 signaling pathway|post-translational protein modification|calcium ion transmembrane transport|site of DNA damage|intrinsic apoptotic signaling pathway "hsa04120,hsa05170" Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection CUL7 674.5965935 686.1102346 663.0829523 0.966437926 -0.049251023 0.900859699 1 6.166648258 6.216401717 9820 cullin 7 "GO:0000226,GO:0000281,GO:0001570,GO:0001837,GO:0001890,GO:0005515,GO:0005680,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0006508,GO:0006511,GO:0007030,GO:0007088,GO:0016032,GO:0016567,GO:0031461,GO:0031467,GO:0031625,GO:0036498,GO:0043687,GO:0048471,GO:0050775,GO:1990393" microtubule cytoskeleton organization|mitotic cytokinesis|vasculogenesis|epithelial to mesenchymal transition|placenta development|protein binding|anaphase-promoting complex|cytoplasm|Golgi apparatus|centrosome|cytosol|proteolysis|ubiquitin-dependent protein catabolic process|Golgi organization|regulation of mitotic nuclear division|viral process|protein ubiquitination|cullin-RING ubiquitin ligase complex|Cul7-RING ubiquitin ligase complex|ubiquitin protein ligase binding|IRE1-mediated unfolded protein response|post-translational protein modification|perinuclear region of cytoplasm|positive regulation of dendrite morphogenesis|3M complex hsa04120 Ubiquitin mediated proteolysis CUL9 704.8874122 668.8559832 740.9188412 1.10774047 0.147619915 0.697703491 1 3.745184739 4.32740156 23113 cullin 9 "GO:0000226,GO:0005515,GO:0005524,GO:0005829,GO:0006511,GO:0007088,GO:0016567,GO:0016740,GO:0031461,GO:0031625,GO:0043687,GO:0046872" microtubule cytoskeleton organization|protein binding|ATP binding|cytosol|ubiquitin-dependent protein catabolic process|regulation of mitotic nuclear division|protein ubiquitination|transferase activity|cullin-RING ubiquitin ligase complex|ubiquitin protein ligase binding|post-translational protein modification|metal ion binding CUTA 1121.126247 1104.272094 1137.980401 1.030525364 0.043380014 0.902644257 1 50.02458489 53.77223755 51596 cutA divalent cation tolerance homolog "GO:0005507,GO:0005515,GO:0008104,GO:0010038,GO:0016020,GO:0019899,GO:0070062" copper ion binding|protein binding|protein localization|response to metal ion|membrane|enzyme binding|extracellular exosome CUTC 578.6575223 627.2427885 530.0722561 0.845083062 -0.242834947 0.539388982 1 23.84957542 21.02306237 51076 cutC copper transporter "GO:0005507,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006825,GO:0051262,GO:0055070" copper ion binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|copper ion transport|protein tetramerization|copper ion homeostasis CUX1 2262.315319 2401.385821 2123.244818 0.884174796 -0.177596486 0.579351368 1 7.59044625 7.00037604 1523 cut like homeobox 1 "GO:0000122,GO:0000139,GO:0000301,GO:0000785,GO:0000977,GO:0000981,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006357,GO:0007275,GO:0030674,GO:0043565,GO:0050775,GO:1990837" "negative regulation of transcription by RNA polymerase II|Golgi membrane|retrograde transport, vesicle recycling within Golgi|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|multicellular organism development|protein-macromolecule adaptor activity|sequence-specific DNA binding|positive regulation of dendrite morphogenesis|sequence-specific double-stranded DNA binding" CUT CUZD1 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.078759866 0.132915382 50624 CUB and zona pellucida like domains 1 "GO:0007049,GO:0007155,GO:0016020,GO:0016021,GO:0030658,GO:0032023,GO:0042589,GO:0051301" cell cycle|cell adhesion|membrane|integral component of membrane|transport vesicle membrane|trypsinogen activation|zymogen granule membrane|cell division CWC15 729.1842507 747.0075927 711.3609087 0.952280694 -0.07054121 0.853792056 1 21.656153 21.51108025 51503 CWC15 spliceosome associated protein homolog "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005739,GO:0016607,GO:0045292,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|mitochondrion|nuclear speck|mRNA cis splicing, via spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome CWC22 423.6877014 439.4759343 407.8994685 0.928149727 -0.107570538 0.80541099 1 6.015650188 5.823935345 57703 CWC22 spliceosome associated protein homolog "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0016607,GO:0048024,GO:0071005,GO:0071006,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytosol|nuclear speck|regulation of mRNA splicing, via spliceosome|U2-type precatalytic spliceosome|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" CWC25 514.0417931 520.6724118 507.4111745 0.974530555 -0.037220675 0.931860689 1 8.598050484 8.73999896 54883 CWC25 spliceosome associated protein homolog "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005684,GO:0016607,GO:0071006" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|U2-type spliceosomal complex|nuclear speck|U2-type catalytic step 1 spliceosome" CWC27 503.4292928 502.4032043 504.4553813 1.004084721 0.005881004 0.99405673 1 2.686617034 2.8137924 10283 CWC27 spliceosome associated cyclophilin "GO:0000398,GO:0000413,GO:0003755,GO:0005654,GO:0006457,GO:0016018,GO:0071005,GO:0071013" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|nucleoplasm|protein folding|cyclosporin A binding|U2-type precatalytic spliceosome|catalytic step 2 spliceosome" CWF19L1 1554.775957 1483.865626 1625.686287 1.095575138 0.131688432 0.690974891 1 28.51007556 32.58040407 55280 CWF19 like cell cycle control factor 1 "GO:0000398,GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0050790,GO:0061632,GO:0071014" "mRNA splicing, via spliceosome|molecular_function|protein binding|cellular_component|biological_process|regulation of catalytic activity|RNA lariat debranching enzyme activator activity|post-mRNA release spliceosomal complex" CWF19L2 328.5314969 299.4120107 357.6509832 1.194511143 0.256420312 0.579682572 1 4.19711101 5.22945694 143884 CWF19 like cell cycle control factor 2 "GO:0000398,GO:0005515,GO:0071014" "mRNA splicing, via spliceosome|protein binding|post-mRNA release spliceosomal complex" CXCL1 7418.563307 10104.90162 4732.224993 0.468309853 -1.094464703 0.000992511 0.090285171 435.9264218 212.9425339 2919 C-X-C motif chemokine ligand 1 "GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007165,GO:0007186,GO:0007399,GO:0008009,GO:0008047,GO:0008083,GO:0008285,GO:0019221,GO:0030036,GO:0030593,GO:0035556,GO:0035580,GO:0043312,GO:0045236,GO:0050790,GO:0061844,GO:0070098,GO:0071222,GO:1904724" signaling receptor binding|protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|nervous system development|chemokine activity|enzyme activator activity|growth factor activity|negative regulation of cell population proliferation|cytokine-mediated signaling pathway|actin cytoskeleton organization|neutrophil chemotaxis|intracellular signal transduction|specific granule lumen|neutrophil degranulation|CXCR chemokine receptor binding|regulation of catalytic activity|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide|tertiary granule lumen "hsa04060,hsa04061,hsa04062,hsa04064,hsa04621,hsa04657,hsa04668,hsa05120,hsa05134,hsa05146,hsa05167,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|NF-kappa B signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Legionellosis|Amoebiasis|Kaposi sarcoma-associated herpesvirus infection|Rheumatoid arthritis CXCL11 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.173779375 0 6373 C-X-C motif chemokine ligand 11 "GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007165,GO:0007186,GO:0007189,GO:0007267,GO:0008009,GO:0008201,GO:0010818,GO:0030593,GO:0042127,GO:0045236,GO:0048248,GO:0051281,GO:0061844,GO:0070098,GO:0071222" protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|heparin binding|T cell chemotaxis|neutrophil chemotaxis|regulation of cell population proliferation|CXCR chemokine receptor binding|CXCR3 chemokine receptor binding|positive regulation of release of sequestered calcium ion into cytosol|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide "hsa04060,hsa04061,hsa04062,hsa04620" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|Toll-like receptor signaling pathway CXCL16 171.8853411 165.4378228 178.3328594 1.077944912 0.108283452 0.857641231 1 3.494095954 3.928686043 58191 C-X-C motif chemokine ligand 16 "GO:0005041,GO:0005044,GO:0005576,GO:0005615,GO:0005886,GO:0006898,GO:0006935,GO:0007186,GO:0008009,GO:0010818,GO:0016020,GO:0016021,GO:0030307,GO:0030335,GO:0034097,GO:0034341,GO:0034612" low-density lipoprotein particle receptor activity|scavenger receptor activity|extracellular region|extracellular space|plasma membrane|receptor-mediated endocytosis|chemotaxis|G protein-coupled receptor signaling pathway|chemokine activity|T cell chemotaxis|membrane|integral component of membrane|positive regulation of cell growth|positive regulation of cell migration|response to cytokine|response to interferon-gamma|response to tumor necrosis factor "hsa04060,hsa04062" Cytokine-cytokine receptor interaction|Chemokine signaling pathway CXCL2 315.940303 381.6234441 250.2571618 0.655769884 -0.608738446 0.191037386 1 17.33442256 11.85705344 2920 C-X-C motif chemokine ligand 2 "GO:0002237,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007186,GO:0008009,GO:0019221,GO:0030593,GO:0045236,GO:0061844,GO:0070098,GO:0071222" response to molecule of bacterial origin|protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|G protein-coupled receptor signaling pathway|chemokine activity|cytokine-mediated signaling pathway|neutrophil chemotaxis|CXCR chemokine receptor binding|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide "hsa04060,hsa04061,hsa04062,hsa04064,hsa04621,hsa04657,hsa04668,hsa05120,hsa05134,hsa05146,hsa05167,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|NF-kappa B signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Legionellosis|Amoebiasis|Kaposi sarcoma-associated herpesvirus infection|Rheumatoid arthritis CXCL3 121.1145321 163.4079109 78.82115332 0.482358246 -1.051823064 0.099526682 1 7.698636483 3.873463346 2921 C-X-C motif chemokine ligand 3 "GO:0005576,GO:0005615,GO:0006954,GO:0007186,GO:0008009,GO:0030593,GO:0045236,GO:0061844,GO:0070098,GO:0071222" extracellular region|extracellular space|inflammatory response|G protein-coupled receptor signaling pathway|chemokine activity|neutrophil chemotaxis|CXCR chemokine receptor binding|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide "hsa04060,hsa04061,hsa04062,hsa04064,hsa04621,hsa04657,hsa04668,hsa05120,hsa05134,hsa05146,hsa05167,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|NF-kappa B signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Legionellosis|Amoebiasis|Kaposi sarcoma-associated herpesvirus infection|Rheumatoid arthritis CXCL5 43.31649957 64.95718198 21.67581716 0.333693927 -1.583402663 0.078039454 1 1.350514003 0.470070854 6374 C-X-C motif chemokine ligand 5 "GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007165,GO:0007186,GO:0007267,GO:0008009,GO:0008284,GO:0030593,GO:0042802,GO:0045236,GO:0061844,GO:0070098,GO:0071222" protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|positive regulation of cell population proliferation|neutrophil chemotaxis|identical protein binding|CXCR chemokine receptor binding|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide "hsa04060,hsa04061,hsa04062,hsa04657,hsa04668,hsa05133,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Pertussis|Rheumatoid arthritis CXCL6 429.5599477 739.9029009 119.2169944 0.161125189 -2.633746048 6.54E-09 4.22E-06 24.38091849 4.097598769 6372 C-X-C motif chemokine ligand 6 "GO:0001776,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007165,GO:0007186,GO:0007267,GO:0008009,GO:0008201,GO:0030593,GO:0032642,GO:0042119,GO:0042742,GO:0045236,GO:0061844,GO:0070098,GO:0070951,GO:0071222" leukocyte homeostasis|protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|heparin binding|neutrophil chemotaxis|regulation of chemokine production|neutrophil activation|defense response to bacterium|CXCR chemokine receptor binding|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|regulation of neutrophil mediated killing of gram-negative bacterium|cellular response to lipopolysaccharide "hsa04060,hsa04061,hsa04062,hsa04657,hsa04668,hsa05133,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Pertussis|Rheumatoid arthritis CXCL8 7017.203645 9171.14213 4863.26516 0.530279118 -0.915176157 0.005548828 0.288156389 282.8781943 156.4659805 3576 C-X-C motif chemokine ligand 8 "GO:0001525,GO:0002237,GO:0005153,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007050,GO:0007165,GO:0007186,GO:0008009,GO:0008285,GO:0010628,GO:0010629,GO:0019221,GO:0019722,GO:0030155,GO:0030593,GO:0031328,GO:0031623,GO:0034976,GO:0035556,GO:0036499,GO:0042119,GO:0044344,GO:0045091,GO:0045236,GO:0045744,GO:0045766,GO:0048566,GO:0050930,GO:0060354,GO:0061844,GO:0070098,GO:0071222,GO:0071347,GO:0071356,GO:0090023,GO:2000535" angiogenesis|response to molecule of bacterial origin|interleukin-8 receptor binding|protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|cell cycle arrest|signal transduction|G protein-coupled receptor signaling pathway|chemokine activity|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|cytokine-mediated signaling pathway|calcium-mediated signaling|regulation of cell adhesion|neutrophil chemotaxis|positive regulation of cellular biosynthetic process|receptor internalization|response to endoplasmic reticulum stress|intracellular signal transduction|PERK-mediated unfolded protein response|neutrophil activation|cellular response to fibroblast growth factor stimulus|regulation of single stranded viral RNA replication via double stranded DNA intermediate|CXCR chemokine receptor binding|negative regulation of G protein-coupled receptor signaling pathway|positive regulation of angiogenesis|embryonic digestive tract development|induction of positive chemotaxis|negative regulation of cell adhesion molecule production|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|positive regulation of neutrophil chemotaxis|regulation of entry of bacterium into host cell "hsa04060,hsa04061,hsa04062,hsa04064,hsa04072,hsa04218,hsa04620,hsa04621,hsa04622,hsa04657,hsa04932,hsa04933,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05142,hsa05144,hsa05146,hsa05161,hsa05163,hsa05164,hsa05167,hsa05171,hsa05200,hsa05202,hsa05219,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|NF-kappa B signaling pathway|Phospholipase D signaling pathway|Cellular senescence|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Chagas disease|Malaria|Amoebiasis|Hepatitis B|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Coronavirus disease - COVID-19|Pathways in cancer|Transcriptional misregulation in cancer|Bladder cancer|Rheumatoid arthritis CXCR4 15.59820553 22.3290313 8.867379749 0.397123352 -1.332340898 0.27535031 1 0.444356253 0.184065608 7852 C-X-C motif chemokine receptor 4 "GO:0000187,GO:0001618,GO:0001666,GO:0001764,GO:0002064,GO:0002407,GO:0003779,GO:0004930,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005769,GO:0005770,GO:0005886,GO:0006915,GO:0006954,GO:0006955,GO:0007186,GO:0007204,GO:0007411,GO:0007420,GO:0008038,GO:0009615,GO:0009897,GO:0009986,GO:0014823,GO:0015026,GO:0016021,GO:0016493,GO:0016494,GO:0019064,GO:0019722,GO:0019957,GO:0022008,GO:0022029,GO:0030054,GO:0030155,GO:0031252,GO:0031410,GO:0031625,GO:0032027,GO:0032991,GO:0035470,GO:0035690,GO:0038147,GO:0038160,GO:0042802,GO:0043067,GO:0043130,GO:0043217,GO:0043278,GO:0045446,GO:0048714,GO:0050792,GO:0050920,GO:0050921,GO:0050965,GO:0050966,GO:0051924,GO:0060048,GO:0060326,GO:0061154,GO:0070062,GO:0071345,GO:0120162,GO:1903861,GO:1905322,GO:1990478,GO:2000448" activation of MAPK activity|virus receptor activity|response to hypoxia|neuron migration|epithelial cell development|dendritic cell chemotaxis|actin binding|G protein-coupled receptor activity|protein binding|nucleus|cytoplasm|lysosome|early endosome|late endosome|plasma membrane|apoptotic process|inflammatory response|immune response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|axon guidance|brain development|neuron recognition|response to virus|external side of plasma membrane|cell surface|response to activity|coreceptor activity|integral component of membrane|C-C chemokine receptor activity|C-X-C chemokine receptor activity|fusion of virus membrane with host plasma membrane|calcium-mediated signaling|C-C chemokine binding|neurogenesis|telencephalon cell migration|cell junction|regulation of cell adhesion|cell leading edge|cytoplasmic vesicle|ubiquitin protein ligase binding|myosin light chain binding|protein-containing complex|positive regulation of vascular wound healing|cellular response to drug|C-X-C motif chemokine 12 receptor activity|CXCL12-activated CXCR4 signaling pathway|identical protein binding|regulation of programmed cell death|ubiquitin binding|myelin maintenance|response to morphine|endothelial cell differentiation|positive regulation of oligodendrocyte differentiation|regulation of viral process|regulation of chemotaxis|positive regulation of chemotaxis|detection of temperature stimulus involved in sensory perception of pain|detection of mechanical stimulus involved in sensory perception of pain|regulation of calcium ion transport|cardiac muscle contraction|cell chemotaxis|endothelial tube morphogenesis|extracellular exosome|cellular response to cytokine stimulus|positive regulation of cold-induced thermogenesis|positive regulation of dendrite extension|positive regulation of mesenchymal stem cell migration|response to ultrasound|positive regulation of macrophage migration inhibitory factor signaling pathway "hsa04020,hsa04060,hsa04061,hsa04062,hsa04144,hsa04360,hsa04670,hsa04672,hsa04810,hsa05163,hsa05170,hsa05200" Calcium signaling pathway|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|Endocytosis|Axon guidance|Leukocyte transendothelial migration|Intestinal immune network for IgA production|Regulation of actin cytoskeleton|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer CXXC1 1107.980316 1215.91725 1000.043383 0.822460067 -0.281982462 0.415952828 1 25.42606078 21.81272034 30827 CXXC finger protein 1 "GO:0000987,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0008270,GO:0016363,GO:0016607,GO:0035064,GO:0035097,GO:0036498,GO:0042800,GO:0045322,GO:0045893,GO:0048188,GO:0051568" "cis-regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|zinc ion binding|nuclear matrix|nuclear speck|methylated histone binding|histone methyltransferase complex|IRE1-mediated unfolded protein response|histone methyltransferase activity (H3-K4 specific)|unmethylated CpG binding|positive regulation of transcription, DNA-templated|Set1C/COMPASS complex|histone H3-K4 methylation" CXXC4 42.15308584 52.77771036 31.52846133 0.597382136 -0.743273999 0.410286886 1 0.464627993 0.289516642 80319 CXXC finger protein 4 "GO:0005634,GO:0005737,GO:0007352,GO:0008270,GO:0008327,GO:0016055,GO:0030165,GO:0030178,GO:0031410" nucleus|cytoplasm|zygotic specification of dorsal/ventral axis|zinc ion binding|methyl-CpG binding|Wnt signaling pathway|PDZ domain binding|negative regulation of Wnt signaling pathway|cytoplasmic vesicle hsa04310 Wnt signaling pathway CXXC5 75.32274733 63.94222601 86.70326866 1.355962625 0.439317414 0.561843682 1 0.908400609 1.284816383 51523 CXXC finger protein 5 "GO:0000122,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0008134,GO:0008270,GO:0008327,GO:0043123,GO:0043565" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|nucleoplasm|cytosol|transcription factor binding|zinc ion binding|methyl-CpG binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|sequence-specific DNA binding CXorf38 827.9779164 765.2768002 890.6790326 1.163865195 0.218923968 0.549601907 1 7.161598336 8.69417886 159013 chromosome X open reading frame 38 GO:0005515 protein binding CYB561 995.7898256 1090.06271 901.5169411 0.827032182 -0.273984626 0.437637319 1 14.58210004 12.57935613 1534 cytochrome b561 "GO:0000293,GO:0005515,GO:0005765,GO:0016021,GO:0016491,GO:0022900,GO:0030658,GO:0046872" ferric-chelate reductase activity|protein binding|lysosomal membrane|integral component of membrane|oxidoreductase activity|electron transport chain|transport vesicle membrane|metal ion binding CYB561A3 981.8558308 979.4325095 984.2791521 1.004948419 0.007121454 0.987179128 1 13.71814197 14.37987114 220002 cytochrome b561 family member A3 "GO:0005515,GO:0005730,GO:0005765,GO:0016021,GO:0016491,GO:0031902,GO:0043231,GO:0046872,GO:0055114" protein binding|nucleolus|lysosomal membrane|integral component of membrane|oxidoreductase activity|late endosome membrane|intracellular membrane-bounded organelle|metal ion binding|oxidation-reduction process CYB561D1 557.2543723 578.524902 535.9838426 0.92646633 -0.110189549 0.78522582 1 5.226586759 5.05084143 284613 cytochrome b561 family member D1 "GO:0005515,GO:0016021,GO:0016491,GO:0020037,GO:0046872,GO:0055114" protein binding|integral component of membrane|oxidoreductase activity|heme binding|metal ion binding|oxidation-reduction process CYB561D2 426.5692657 434.4011545 418.737377 0.963941676 -0.052982237 0.90643961 1 18.21265397 18.31217473 11068 cytochrome b561 family member D2 "GO:0004322,GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0016491,GO:0020037,GO:0030659,GO:0031982,GO:0046872,GO:0055114" ferroxidase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|oxidoreductase activity|heme binding|cytoplasmic vesicle membrane|vesicle|metal ion binding|oxidation-reduction process CYB5A 437.7216572 422.2216828 453.2216316 1.073421025 0.102216052 0.813458694 1 5.136689581 5.751344056 1528 cytochrome b5 type A "GO:0004129,GO:0005515,GO:0005741,GO:0005789,GO:0005829,GO:0009055,GO:0016020,GO:0016021,GO:0019852,GO:0019899,GO:0020037,GO:0022900,GO:0043231,GO:0046686,GO:0046872,GO:1902600" cytochrome-c oxidase activity|protein binding|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|electron transfer activity|membrane|integral component of membrane|L-ascorbic acid metabolic process|enzyme binding|heme binding|electron transport chain|intracellular membrane-bounded organelle|response to cadmium ion|metal ion binding|proton transmembrane transport CYB5B 1723.509788 1669.602568 1777.417007 1.064574912 0.090277473 0.783352152 1 19.8403285 22.03134522 80777 cytochrome b5 type B "GO:0005515,GO:0005741,GO:0006805,GO:0006809,GO:0008047,GO:0009055,GO:0016020,GO:0016021,GO:0020037,GO:0022900,GO:0043231,GO:0046872,GO:0050421,GO:0050790,GO:1903958" protein binding|mitochondrial outer membrane|xenobiotic metabolic process|nitric oxide biosynthetic process|enzyme activator activity|electron transfer activity|membrane|integral component of membrane|heme binding|electron transport chain|intracellular membrane-bounded organelle|metal ion binding|nitrite reductase (NO-forming) activity|regulation of catalytic activity|nitric-oxide synthase complex CYB5D1 653.6994376 840.3835418 467.0153334 0.555716896 -0.84757799 0.027640389 0.734583991 12.19904319 7.071235482 124637 cytochrome b5 domain containing 1 GO:0046872 metal ion binding CYB5D2 496.4230783 562.2856065 430.56055 0.765732832 -0.385086978 0.347299987 1 7.751165581 6.190991573 124936 cytochrome b5 domain containing 2 "GO:0005515,GO:0005576,GO:0007399,GO:0012505,GO:0016020,GO:0020037,GO:0045666" protein binding|extracellular region|nervous system development|endomembrane system|membrane|heme binding|positive regulation of neuron differentiation CYB5R1 830.0172309 837.3386739 822.6957878 0.982512588 -0.025452203 0.947851771 1 26.11345436 26.76198842 51706 cytochrome b5 reductase 1 "GO:0002576,GO:0004128,GO:0005515,GO:0005739,GO:0005789,GO:0005886,GO:0015701,GO:0016020,GO:0016021,GO:0016126,GO:0031092,GO:0055114,GO:0070062,GO:0071949" "platelet degranulation|cytochrome-b5 reductase activity, acting on NAD(P)H|protein binding|mitochondrion|endoplasmic reticulum membrane|plasma membrane|bicarbonate transport|membrane|integral component of membrane|sterol biosynthetic process|platelet alpha granule membrane|oxidation-reduction process|extracellular exosome|FAD binding" hsa00520 Amino sugar and nucleotide sugar metabolism CYB5R3 7262.373896 7105.706735 7419.041057 1.044096152 0.062254577 0.849920965 1 102.7638431 111.917181 1727 cytochrome b5 reductase 3 "GO:0004128,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0005811,GO:0005833,GO:0006695,GO:0006805,GO:0006809,GO:0008015,GO:0016020,GO:0016208,GO:0019852,GO:0035578,GO:0043312,GO:0043531,GO:0050421,GO:0051287,GO:0055114,GO:0071949,GO:1903958" "cytochrome-b5 reductase activity, acting on NAD(P)H|protein binding|extracellular region|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|hemoglobin complex|cholesterol biosynthetic process|xenobiotic metabolic process|nitric oxide biosynthetic process|blood circulation|membrane|AMP binding|L-ascorbic acid metabolic process|azurophil granule lumen|neutrophil degranulation|ADP binding|nitrite reductase (NO-forming) activity|NAD binding|oxidation-reduction process|FAD binding|nitric-oxide synthase complex" hsa00520 Amino sugar and nucleotide sugar metabolism CYB5R4 550.5411139 523.7172797 577.3649481 1.102436315 0.140695318 0.727358369 1 2.88152446 3.31353644 51167 cytochrome b5 reductase 4 "GO:0003032,GO:0004128,GO:0005783,GO:0005789,GO:0006091,GO:0006801,GO:0015701,GO:0016174,GO:0016653,GO:0020037,GO:0030073,GO:0042593,GO:0046677,GO:0046872,GO:0048468,GO:0048471,GO:0055114" "detection of oxygen|cytochrome-b5 reductase activity, acting on NAD(P)H|endoplasmic reticulum|endoplasmic reticulum membrane|generation of precursor metabolites and energy|superoxide metabolic process|bicarbonate transport|NAD(P)H oxidase H2O2-forming activity|oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor|heme binding|insulin secretion|glucose homeostasis|response to antibiotic|metal ion binding|cell development|perinuclear region of cytoplasm|oxidation-reduction process" hsa00520 Amino sugar and nucleotide sugar metabolism CYB5RL 309.0961542 284.1876711 334.0046372 1.175296014 0.233024165 0.622203394 1 2.252441782 2.761320187 606495 cytochrome b5 reductase like "GO:0004128,GO:0005654,GO:0005789,GO:0015701,GO:0055114" "cytochrome-b5 reductase activity, acting on NAD(P)H|nucleoplasm|endoplasmic reticulum membrane|bicarbonate transport|oxidation-reduction process" hsa00520 Amino sugar and nucleotide sugar metabolism CYBA 4707.115118 4783.487479 4630.742758 0.968068335 -0.046819206 0.88434519 1 94.48781813 95.41085001 1535 cytochrome b-245 alpha chain "GO:0002479,GO:0005515,GO:0005789,GO:0005886,GO:0006801,GO:0006954,GO:0009055,GO:0014895,GO:0016020,GO:0016175,GO:0017004,GO:0017124,GO:0020037,GO:0022900,GO:0030141,GO:0030670,GO:0032755,GO:0032760,GO:0034137,GO:0034599,GO:0035579,GO:0042554,GO:0043020,GO:0043312,GO:0045087,GO:0045454,GO:0045730,GO:0046872,GO:0046982,GO:0048010,GO:0050665,GO:0050766,GO:0055114,GO:0070821,GO:1900426,GO:1903428" "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|endoplasmic reticulum membrane|plasma membrane|superoxide metabolic process|inflammatory response|electron transfer activity|smooth muscle hypertrophy|membrane|superoxide-generating NAD(P)H oxidase activity|cytochrome complex assembly|SH3 domain binding|heme binding|electron transport chain|secretory granule|phagocytic vesicle membrane|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of toll-like receptor 2 signaling pathway|cellular response to oxidative stress|specific granule membrane|superoxide anion generation|NADPH oxidase complex|neutrophil degranulation|innate immune response|cell redox homeostasis|respiratory burst|metal ion binding|protein heterodimerization activity|vascular endothelial growth factor receptor signaling pathway|hydrogen peroxide biosynthetic process|positive regulation of phagocytosis|oxidation-reduction process|tertiary granule membrane|positive regulation of defense response to bacterium|positive regulation of reactive oxygen species biosynthetic process" "hsa04145,hsa04380,hsa04621,hsa04670,hsa05020,hsa05140,hsa05418" Phagosome|Osteoclast differentiation|NOD-like receptor signaling pathway|Leukocyte transendothelial migration|Prion disease|Leishmaniasis|Fluid shear stress and atherosclerosis CYBC1 531.553866 505.4480723 557.6596598 1.103297629 0.14182203 0.727596056 1 10.27253682 11.82187386 79415 cytochrome b-245 chaperone 1 "GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0045087,GO:0045728" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|innate immune response|respiratory burst after phagocytosis CYBRD1 2100.644856 1452.401991 2748.887722 1.892649376 0.920407169 0.00442404 0.245751792 17.13065605 33.81894777 79901 cytochrome b reductase 1 "GO:0000293,GO:0005515,GO:0005765,GO:0005886,GO:0006879,GO:0010039,GO:0016021,GO:0016491,GO:0031526,GO:0046872,GO:0055114,GO:0070062" ferric-chelate reductase activity|protein binding|lysosomal membrane|plasma membrane|cellular iron ion homeostasis|response to iron ion|integral component of membrane|oxidoreductase activity|brush border membrane|metal ion binding|oxidation-reduction process|extracellular exosome hsa04978 Mineral absorption CYC1 3902.069467 4171.46903 3632.669904 0.870837079 -0.199525259 0.531262144 1 117.6992704 106.912039 1537 cytochrome c1 "GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005750,GO:0006122,GO:0016020,GO:0016021,GO:0020037,GO:0033762,GO:0045153,GO:0045155,GO:0046872" "protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|membrane|integral component of membrane|heme binding|response to glucagon|electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity|electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|metal ion binding" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases CYCS 2150.039713 2404.430689 1895.648737 0.788398163 -0.343003681 0.285109896 1 22.41824965 18.4358529 54205 "cytochrome c, somatic" "GO:0000159,GO:0004722,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005758,GO:0005829,GO:0006122,GO:0006123,GO:0006470,GO:0006915,GO:0007005,GO:0008635,GO:0020037,GO:0034599,GO:0043280,GO:0045155,GO:0045333,GO:0046872,GO:0070469" "protein phosphatase type 2A complex|protein serine/threonine phosphatase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|mitochondrial electron transport, ubiquinol to cytochrome c|mitochondrial electron transport, cytochrome c to oxygen|protein dephosphorylation|apoptotic process|mitochondrion organization|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|heme binding|cellular response to oxidative stress|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|cellular respiration|metal ion binding|respirasome" "hsa01524,hsa04115,hsa04210,hsa04215,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05130,hsa05131,hsa05132,hsa05134,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05210,hsa05222,hsa05416" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Legionellosis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Small cell lung cancer|Viral myocarditis CYFIP1 2910.910532 2859.130963 2962.690101 1.036220495 0.051331023 0.872794854 1 18.19385562 19.66495022 23191 cytoplasmic FMR1 interacting protein 1 "GO:0000340,GO:0000902,GO:0001726,GO:0005515,GO:0005576,GO:0005829,GO:0005845,GO:0005925,GO:0006417,GO:0007411,GO:0008360,GO:0010592,GO:0016601,GO:0030027,GO:0030031,GO:0030032,GO:0031209,GO:0031267,GO:0031529,GO:0031641,GO:0032433,GO:0032869,GO:0034774,GO:0035580,GO:0038096,GO:0043005,GO:0043025,GO:0043195,GO:0043197,GO:0043312,GO:0044294,GO:0044295,GO:0045182,GO:0045202,GO:0045773,GO:0048010,GO:0048471,GO:0048675,GO:0050890,GO:0051015,GO:0051388,GO:0051602,GO:0060076,GO:0070062,GO:0090724,GO:0090725,GO:0097484,GO:0099563,GO:0099578,GO:1900006,GO:1900029,GO:1903422,GO:1904724,GO:1905274,GO:2000601" "RNA 7-methylguanosine cap binding|cell morphogenesis|ruffle|protein binding|extracellular region|cytosol|mRNA cap binding complex|focal adhesion|regulation of translation|axon guidance|regulation of cell shape|positive regulation of lamellipodium assembly|Rac protein signal transduction|lamellipodium|cell projection assembly|lamellipodium assembly|SCAR complex|small GTPase binding|ruffle organization|regulation of myelination|filopodium tip|cellular response to insulin stimulus|secretory granule lumen|specific granule lumen|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|neuronal cell body|terminal bouton|dendritic spine|neutrophil degranulation|dendritic growth cone|axonal growth cone|translation regulator activity|synapse|positive regulation of axon extension|vascular endothelial growth factor receptor signaling pathway|perinuclear region of cytoplasm|axon extension|cognition|actin filament binding|positive regulation of neurotrophin TRK receptor signaling pathway|response to electrical stimulus|excitatory synapse|extracellular exosome|central region of growth cone|peripheral region of growth cone|dendrite extension|modification of synaptic structure|regulation of translation at postsynapse, modulating synaptic transmission|positive regulation of dendrite development|positive regulation of ruffle assembly|negative regulation of synaptic vesicle recycling|tertiary granule lumen|regulation of modification of postsynaptic actin cytoskeleton|positive regulation of Arp2/3 complex-mediated actin nucleation" "hsa03013,hsa04810,hsa05130,hsa05132" RNA transport|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection CYFIP2 49.54256897 52.77771036 46.30742758 0.877405012 -0.188685148 0.845105365 1 0.372804022 0.341190264 26999 cytoplasmic FMR1 interacting protein 2 "GO:0000340,GO:0000902,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0016020,GO:0030833,GO:0031209,GO:0038096,GO:0043005,GO:0045202,GO:0045862,GO:0048010,GO:0048471,GO:0070062,GO:0097202,GO:0098609" RNA 7-methylguanosine cap binding|cell morphogenesis|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|membrane|regulation of actin filament polymerization|SCAR complex|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|synapse|positive regulation of proteolysis|vascular endothelial growth factor receptor signaling pathway|perinuclear region of cytoplasm|extracellular exosome|activation of cysteine-type endopeptidase activity|cell-cell adhesion "hsa03013,hsa04810,hsa05130,hsa05132" RNA transport|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection CYGB 29.89938534 23.34398727 36.45478341 1.561634822 0.643057128 0.526884286 1 0.313771391 0.511103386 114757 cytoglobin "GO:0004601,GO:0005344,GO:0005506,GO:0005515,GO:0005829,GO:0006979,GO:0015671,GO:0019825,GO:0020037,GO:0050999,GO:0098869" peroxidase activity|oxygen carrier activity|iron ion binding|protein binding|cytosol|response to oxidative stress|oxygen transport|oxygen binding|heme binding|regulation of nitric-oxide synthase activity|cellular oxidant detoxification CYHR1 1110.204707 1031.195264 1189.214151 1.153238569 0.205690993 0.553338283 1 14.60469862 17.56821703 50626 cysteine and histidine rich 1 "GO:0005515,GO:0005654,GO:0008270,GO:0048471" protein binding|nucleoplasm|zinc ion binding|perinuclear region of cytoplasm CYLD 474.9241726 405.9823873 543.8659579 1.339629439 0.421833986 0.308638064 1 2.269489592 3.171237789 1540 CYLD lysine 63 deubiquitinase "GO:0004843,GO:0005515,GO:0005813,GO:0005819,GO:0005829,GO:0005881,GO:0006511,GO:0007049,GO:0007346,GO:0008234,GO:0008270,GO:0010803,GO:0016055,GO:0016579,GO:0018215,GO:0019901,GO:0030496,GO:0031234,GO:0032088,GO:0032480,GO:0036064,GO:0045087,GO:0046329,GO:0048471,GO:0050727,GO:0060544,GO:0061578,GO:0070064,GO:0070266,GO:0070423,GO:0070507,GO:0070536,GO:0090090,GO:0097542,GO:1901223,GO:1902017,GO:1903753,GO:1990108,GO:2001238,GO:2001242" thiol-dependent ubiquitin-specific protease activity|protein binding|centrosome|spindle|cytosol|cytoplasmic microtubule|ubiquitin-dependent protein catabolic process|cell cycle|regulation of mitotic cell cycle|cysteine-type peptidase activity|zinc ion binding|regulation of tumor necrosis factor-mediated signaling pathway|Wnt signaling pathway|protein deubiquitination|protein phosphopantetheinylation|protein kinase binding|midbody|extrinsic component of cytoplasmic side of plasma membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|ciliary basal body|innate immune response|negative regulation of JNK cascade|perinuclear region of cytoplasm|regulation of inflammatory response|regulation of necroptotic process|Lys63-specific deubiquitinase activity|proline-rich region binding|necroptotic process|nucleotide-binding oligomerization domain containing signaling pathway|regulation of microtubule cytoskeleton organization|protein K63-linked deubiquitination|negative regulation of canonical Wnt signaling pathway|ciliary tip|negative regulation of NIK/NF-kappaB signaling|regulation of cilium assembly|negative regulation of p38MAPK cascade|protein linear deubiquitination|positive regulation of extrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway "hsa04064,hsa04217,hsa04380,hsa04622,hsa04625" NF-kappa B signaling pathway|Necroptosis|Osteoclast differentiation|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway CYP11A1 7.567632435 12.17947162 2.95579325 0.242686493 -2.042834281 0.21196309 1 0.266341654 0.067421844 1583 cytochrome P450 family 11 subfamily A member 1 "GO:0005506,GO:0005515,GO:0005739,GO:0005743,GO:0005759,GO:0006700,GO:0006704,GO:0008203,GO:0008386,GO:0016125,GO:0020037,GO:0034650,GO:0042359,GO:0055114,GO:0071375" iron ion binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|C21-steroid hormone biosynthetic process|glucocorticoid biosynthetic process|cholesterol metabolic process|cholesterol monooxygenase (side-chain-cleaving) activity|sterol metabolic process|heme binding|cortisol metabolic process|vitamin D metabolic process|oxidation-reduction process|cellular response to peptide hormone stimulus "hsa00140,hsa04913,hsa04925,hsa04927,hsa04934" Steroid hormone biosynthesis|Ovarian steroidogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome CYP1A1 53.10703903 94.39090506 11.823173 0.125257545 -2.997030592 0.000977138 0.089487377 1.836560257 0.239952349 1543 cytochrome P450 family 1 subfamily A member 1 "GO:0001666,GO:0002933,GO:0004497,GO:0005506,GO:0005515,GO:0005743,GO:0005789,GO:0006306,GO:0006631,GO:0006694,GO:0006778,GO:0007568,GO:0008202,GO:0008210,GO:0008283,GO:0008391,GO:0009308,GO:0009611,GO:0009615,GO:0009624,GO:0009635,GO:0009692,GO:0009804,GO:0009812,GO:0010041,GO:0016491,GO:0016679,GO:0016711,GO:0017143,GO:0017144,GO:0019216,GO:0019341,GO:0019373,GO:0019825,GO:0019899,GO:0020037,GO:0030544,GO:0032094,GO:0032451,GO:0032496,GO:0033189,GO:0035902,GO:0042359,GO:0042493,GO:0042572,GO:0042759,GO:0042904,GO:0043010,GO:0043231,GO:0046677,GO:0046685,GO:0048565,GO:0050665,GO:0051879,GO:0055093,GO:0055114,GO:0060137,GO:0070330,GO:0070365,GO:0070576,GO:0070988,GO:0071280,GO:0071407,GO:0097267,GO:0101020,GO:0101021,GO:0106256,GO:1900087" "response to hypoxia|lipid hydroxylation|monooxygenase activity|iron ion binding|protein binding|mitochondrial inner membrane|endoplasmic reticulum membrane|DNA methylation|fatty acid metabolic process|steroid biosynthetic process|porphyrin-containing compound metabolic process|aging|steroid metabolic process|estrogen metabolic process|cell population proliferation|arachidonic acid monooxygenase activity|amine metabolic process|response to wounding|response to virus|response to nematode|response to herbicide|ethylene metabolic process|coumarin metabolic process|flavonoid metabolic process|response to iron(III) ion|oxidoreductase activity|oxidoreductase activity, acting on diphenols and related substances as donors|flavonoid 3'-monooxygenase activity|insecticide metabolic process|drug metabolic process|regulation of lipid metabolic process|dibenzo-p-dioxin catabolic process|epoxygenase P450 pathway|oxygen binding|enzyme binding|heme binding|Hsp70 protein binding|response to food|demethylase activity|response to lipopolysaccharide|response to vitamin A|response to immobilization stress|vitamin D metabolic process|response to drug|retinol metabolic process|long-chain fatty acid biosynthetic process|9-cis-retinoic acid biosynthetic process|camera-type eye development|intracellular membrane-bounded organelle|response to antibiotic|response to arsenic-containing substance|digestive tract development|hydrogen peroxide biosynthetic process|Hsp90 protein binding|response to hyperoxia|oxidation-reduction process|maternal process involved in parturition|aromatase activity|hepatocyte differentiation|vitamin D 24-hydroxylase activity|demethylation|cellular response to copper ion|cellular response to organic cyclic compound|omega-hydroxylase P450 pathway|estrogen 16-alpha-hydroxylase activity|estrogen 2-hydroxylase activity|hydroperoxy icosatetraenoate dehydratase activity|positive regulation of G1/S transition of mitotic cell cycle" "hsa00140,hsa00380,hsa00830,hsa00980,hsa04913,hsa05204" Steroid hormone biosynthesis|Tryptophan metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Ovarian steroidogenesis|Chemical carcinogenesis CYP1B1 15.88299687 8.119647747 23.646346 2.912237912 1.542128219 0.205646857 1 0.078810179 0.239400523 1545 cytochrome P450 family 1 subfamily B member 1 "GO:0001525,GO:0002930,GO:0004497,GO:0005506,GO:0005739,GO:0005789,GO:0006725,GO:0006805,GO:0006809,GO:0007155,GO:0007601,GO:0008202,GO:0008210,GO:0008285,GO:0008631,GO:0009404,GO:0009636,GO:0010575,GO:0016125,GO:0016712,GO:0019369,GO:0019373,GO:0019825,GO:0020037,GO:0030199,GO:0030336,GO:0032088,GO:0033629,GO:0042572,GO:0042574,GO:0043065,GO:0043231,GO:0043542,GO:0045766,GO:0046427,GO:0046466,GO:0048514,GO:0055114,GO:0061304,GO:0070301,GO:0070330,GO:0071407,GO:0071603,GO:0097267,GO:0101020,GO:0106256,GO:2000377" "angiogenesis|trabecular meshwork development|monooxygenase activity|iron ion binding|mitochondrion|endoplasmic reticulum membrane|cellular aromatic compound metabolic process|xenobiotic metabolic process|nitric oxide biosynthetic process|cell adhesion|visual perception|steroid metabolic process|estrogen metabolic process|negative regulation of cell population proliferation|intrinsic apoptotic signaling pathway in response to oxidative stress|toxin metabolic process|response to toxic substance|positive regulation of vascular endothelial growth factor production|sterol metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|arachidonic acid metabolic process|epoxygenase P450 pathway|oxygen binding|heme binding|collagen fibril organization|negative regulation of cell migration|negative regulation of NF-kappaB transcription factor activity|negative regulation of cell adhesion mediated by integrin|retinol metabolic process|retinal metabolic process|positive regulation of apoptotic process|intracellular membrane-bounded organelle|endothelial cell migration|positive regulation of angiogenesis|positive regulation of receptor signaling pathway via JAK-STAT|membrane lipid catabolic process|blood vessel morphogenesis|oxidation-reduction process|retinal blood vessel morphogenesis|cellular response to hydrogen peroxide|aromatase activity|cellular response to organic cyclic compound|endothelial cell-cell adhesion|omega-hydroxylase P450 pathway|estrogen 16-alpha-hydroxylase activity|hydroperoxy icosatetraenoate dehydratase activity|regulation of reactive oxygen species metabolic process" "hsa00140,hsa00380,hsa00980,hsa04913,hsa05204,hsa05206" Steroid hormone biosynthesis|Tryptophan metabolism|Metabolism of xenobiotics by cytochrome P450|Ovarian steroidogenesis|Chemical carcinogenesis|MicroRNAs in cancer CYP20A1 190.0803197 196.9014579 183.2591815 0.930715209 -0.103588312 0.858722602 1 3.976221776 3.860142524 57404 cytochrome P450 family 20 subfamily A member 1 "GO:0004497,GO:0005506,GO:0016020,GO:0016021,GO:0016705,GO:0020037,GO:0055114" "monooxygenase activity|iron ion binding|membrane|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|heme binding|oxidation-reduction process" CYP26A1 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.062257496 0 1592 cytochrome P450 family 26 subfamily A member 1 "GO:0001822,GO:0001972,GO:0004497,GO:0005506,GO:0005789,GO:0006766,GO:0006805,GO:0008401,GO:0016125,GO:0016491,GO:0016709,GO:0019825,GO:0020037,GO:0032526,GO:0033189,GO:0034653,GO:0042573,GO:0048387,GO:0055114,GO:0062183" "kidney development|retinoic acid binding|monooxygenase activity|iron ion binding|endoplasmic reticulum membrane|vitamin metabolic process|xenobiotic metabolic process|retinoic acid 4-hydroxylase activity|sterol metabolic process|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|oxygen binding|heme binding|response to retinoic acid|response to vitamin A|retinoic acid catabolic process|retinoic acid metabolic process|negative regulation of retinoic acid receptor signaling pathway|oxidation-reduction process|all-trans retinoic acid 18-hydroxylase activity" hsa00830 Retinol metabolism CYP26B1 964.9687644 835.308762 1094.628767 1.310448084 0.3900602 0.271486936 1 8.869065409 12.12309777 56603 cytochrome P450 family 26 subfamily B member 1 "GO:0001709,GO:0001768,GO:0001822,GO:0001972,GO:0004497,GO:0005506,GO:0005515,GO:0005737,GO:0005789,GO:0006766,GO:0006805,GO:0006954,GO:0007140,GO:0007283,GO:0008401,GO:0009954,GO:0010628,GO:0016125,GO:0016491,GO:0016709,GO:0020037,GO:0030326,GO:0033189,GO:0034653,GO:0042573,GO:0043587,GO:0045580,GO:0048384,GO:0048387,GO:0055114,GO:0060349,GO:0061436,GO:0070268,GO:0071300,GO:2001037" "cell fate determination|establishment of T cell polarity|kidney development|retinoic acid binding|monooxygenase activity|iron ion binding|protein binding|cytoplasm|endoplasmic reticulum membrane|vitamin metabolic process|xenobiotic metabolic process|inflammatory response|male meiotic nuclear division|spermatogenesis|retinoic acid 4-hydroxylase activity|proximal/distal pattern formation|positive regulation of gene expression|sterol metabolic process|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|heme binding|embryonic limb morphogenesis|response to vitamin A|retinoic acid catabolic process|retinoic acid metabolic process|tongue morphogenesis|regulation of T cell differentiation|retinoic acid receptor signaling pathway|negative regulation of retinoic acid receptor signaling pathway|oxidation-reduction process|bone morphogenesis|establishment of skin barrier|cornification|cellular response to retinoic acid|positive regulation of tongue muscle cell differentiation" hsa00830 Retinol metabolism CYP27A1 63.09873838 36.53841486 89.65906191 2.453830092 1.295035358 0.103142196 1 0.801447299 2.051329319 1593 cytochrome P450 family 27 subfamily A member 1 "GO:0005506,GO:0005739,GO:0005743,GO:0005759,GO:0006699,GO:0006707,GO:0008203,GO:0008395,GO:0016125,GO:0020037,GO:0030343,GO:0031073,GO:0036378,GO:0047749,GO:0055114" iron ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|bile acid biosynthetic process|cholesterol catabolic process|cholesterol metabolic process|steroid hydroxylase activity|sterol metabolic process|heme binding|vitamin D3 25-hydroxylase activity|cholesterol 26-hydroxylase activity|calcitriol biosynthetic process from calciol|cholestanetriol 26-monooxygenase activity|oxidation-reduction process "hsa00120,hsa03320,hsa04979" Primary bile acid biosynthesis|PPAR signaling pathway|Cholesterol metabolism CYP27B1 169.1819261 182.6920743 155.6717778 0.852099241 -0.230906629 0.691236063 1 3.900804833 3.467051798 1594 cytochrome P450 family 27 subfamily B member 1 "GO:0004498,GO:0005506,GO:0005737,GO:0005739,GO:0005741,GO:0006766,GO:0006816,GO:0008285,GO:0010956,GO:0010980,GO:0020037,GO:0030282,GO:0030308,GO:0030500,GO:0032496,GO:0033280,GO:0034341,GO:0036378,GO:0042359,GO:0042369,GO:0043627,GO:0045618,GO:0046697,GO:0055074,GO:0055114,GO:0062185,GO:0070314,GO:0070564" calcidiol 1-monooxygenase activity|iron ion binding|cytoplasm|mitochondrion|mitochondrial outer membrane|vitamin metabolic process|calcium ion transport|negative regulation of cell population proliferation|negative regulation of calcidiol 1-monooxygenase activity|positive regulation of vitamin D 24-hydroxylase activity|heme binding|bone mineralization|negative regulation of cell growth|regulation of bone mineralization|response to lipopolysaccharide|response to vitamin D|response to interferon-gamma|calcitriol biosynthetic process from calciol|vitamin D metabolic process|vitamin D catabolic process|response to estrogen|positive regulation of keratinocyte differentiation|decidualization|calcium ion homeostasis|oxidation-reduction process|secalciferol 1-monooxygenase activity|G1 to G0 transition|positive regulation of vitamin D receptor signaling pathway "hsa00100,hsa04928,hsa05152" "Steroid biosynthesis|Parathyroid hormone synthesis, secretion and action|Tuberculosis" CYP27C1 75.53058819 78.15160956 72.90956682 0.932924699 -0.100167456 0.910503468 1 0.809759272 0.787985907 339761 cytochrome P450 family 27 subfamily C member 1 "GO:0001972,GO:0004497,GO:0005502,GO:0005503,GO:0005506,GO:0005739,GO:0016020,GO:0020037,GO:0042572,GO:0042573,GO:0042574,GO:0043231,GO:0055114,GO:0061896,GO:0061897,GO:0061898,GO:0061899,GO:1904768" "retinoic acid binding|monooxygenase activity|11-cis retinal binding|all-trans retinal binding|iron ion binding|mitochondrion|membrane|heme binding|retinol metabolic process|retinoic acid metabolic process|retinal metabolic process|intracellular membrane-bounded organelle|oxidation-reduction process|all-trans retinol 3,4-desaturase activity|all-trans retinal 3,4-desaturase activity|all-trans retinoic acid 3,4-desaturase activity|11-cis-retinal 3,4-desaturase activity|all-trans-retinol binding" hsa00830 Retinol metabolism CYP2D6 4.044978098 7.104691779 0.985264417 0.138677996 -2.850189203 0.227217187 1 0.226591672 0.032776866 1565 cytochrome P450 family 2 subfamily D member 6 "GO:0004497,GO:0005506,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0006082,GO:0006805,GO:0008202,GO:0008203,GO:0008210,GO:0008395,GO:0009804,GO:0009820,GO:0009822,GO:0016098,GO:0016491,GO:0016712,GO:0017144,GO:0019369,GO:0020037,GO:0033076,GO:0042572,GO:0042737,GO:0042738,GO:0042759,GO:0043231,GO:0046483,GO:0051100,GO:0055114,GO:0062187,GO:0062188,GO:0062189,GO:0070989,GO:0090350" "monooxygenase activity|iron ion binding|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|organic acid metabolic process|xenobiotic metabolic process|steroid metabolic process|cholesterol metabolic process|estrogen metabolic process|steroid hydroxylase activity|coumarin metabolic process|alkaloid metabolic process|alkaloid catabolic process|monoterpenoid metabolic process|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|drug metabolic process|arachidonic acid metabolic process|heme binding|isoquinoline alkaloid metabolic process|retinol metabolic process|drug catabolic process|exogenous drug catabolic process|long-chain fatty acid biosynthetic process|intracellular membrane-bounded organelle|heterocycle metabolic process|negative regulation of binding|oxidation-reduction process|anandamide 8,9 epoxidase activity|anandamide 11,12 epoxidase activity|anandamide 14,15 epoxidase activity|oxidative demethylation|negative regulation of cellular organofluorine metabolic process" "hsa00980,hsa00982,hsa01522,hsa04726" Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Endocrine resistance|Serotonergic synapse CYP2E1 7.552786659 11.16451565 3.941057666 0.352998535 -1.5022659 0.356891946 1 0.337779768 0.124371956 1571 cytochrome P450 family 2 subfamily E member 1 "GO:0000139,GO:0002933,GO:0004497,GO:0005506,GO:0005737,GO:0005743,GO:0005789,GO:0006082,GO:0006641,GO:0006805,GO:0008202,GO:0008392,GO:0008395,GO:0009617,GO:0010193,GO:0010243,GO:0016098,GO:0016491,GO:0016709,GO:0016712,GO:0017144,GO:0018601,GO:0018885,GO:0018910,GO:0018960,GO:0019373,GO:0019825,GO:0019899,GO:0020037,GO:0030544,GO:0031227,GO:0042197,GO:0042738,GO:0042759,GO:0043231,GO:0045471,GO:0046483,GO:0051879,GO:0055114,GO:0070330" "Golgi membrane|lipid hydroxylation|monooxygenase activity|iron ion binding|cytoplasm|mitochondrial inner membrane|endoplasmic reticulum membrane|organic acid metabolic process|triglyceride metabolic process|xenobiotic metabolic process|steroid metabolic process|arachidonic acid epoxygenase activity|steroid hydroxylase activity|response to bacterium|response to ozone|response to organonitrogen compound|monoterpenoid metabolic process|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|drug metabolic process|4-nitrophenol 2-monooxygenase activity|carbon tetrachloride metabolic process|benzene metabolic process|4-nitrophenol metabolic process|epoxygenase P450 pathway|oxygen binding|enzyme binding|heme binding|Hsp70 protein binding|intrinsic component of endoplasmic reticulum membrane|halogenated hydrocarbon metabolic process|exogenous drug catabolic process|long-chain fatty acid biosynthetic process|intracellular membrane-bounded organelle|response to ethanol|heterocycle metabolic process|Hsp90 protein binding|oxidation-reduction process|aromatase activity" "hsa00140,hsa00590,hsa00591,hsa00980,hsa00982,hsa00983,hsa04932,hsa05204" Steroid hormone biosynthesis|Arachidonic acid metabolism|Linoleic acid metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Non-alcoholic fatty liver disease|Chemical carcinogenesis CYP2J2 24.00264462 24.35894324 23.646346 0.970745971 -0.042834281 1 1 0.65656974 0.664817418 1573 cytochrome P450 family 2 subfamily J member 2 "GO:0005506,GO:0005737,GO:0005789,GO:0006082,GO:0006690,GO:0006805,GO:0008016,GO:0008392,GO:0008395,GO:0008404,GO:0008405,GO:0016712,GO:0016853,GO:0019373,GO:0020037,GO:0042738,GO:0043231,GO:0043651,GO:0055114,GO:0070062,GO:0071614,GO:0106255" "iron ion binding|cytoplasm|endoplasmic reticulum membrane|organic acid metabolic process|icosanoid metabolic process|xenobiotic metabolic process|regulation of heart contraction|arachidonic acid epoxygenase activity|steroid hydroxylase activity|arachidonic acid 14,15-epoxygenase activity|arachidonic acid 11,12-epoxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|isomerase activity|epoxygenase P450 pathway|heme binding|exogenous drug catabolic process|intracellular membrane-bounded organelle|linoleic acid metabolic process|oxidation-reduction process|extracellular exosome|linoleic acid epoxygenase activity|hydroperoxy icosatetraenoate isomerase activity" "hsa00590,hsa00591,hsa04726,hsa04750,hsa04913" Arachidonic acid metabolism|Linoleic acid metabolism|Serotonergic synapse|Inflammatory mediator regulation of TRP channels|Ovarian steroidogenesis CYP2R1 62.23224017 44.65806261 79.80641774 1.787055082 0.837584103 0.292147175 1 0.188717007 0.351774949 120227 cytochrome P450 family 2 subfamily R member 1 "GO:0005506,GO:0005737,GO:0005789,GO:0006082,GO:0006766,GO:0006805,GO:0008395,GO:0010164,GO:0010212,GO:0016712,GO:0020037,GO:0030343,GO:0036378,GO:0042359,GO:0042738,GO:0042803,GO:0043231,GO:0055114,GO:1902271" "iron ion binding|cytoplasm|endoplasmic reticulum membrane|organic acid metabolic process|vitamin metabolic process|xenobiotic metabolic process|steroid hydroxylase activity|response to cesium ion|response to ionizing radiation|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|heme binding|vitamin D3 25-hydroxylase activity|calcitriol biosynthetic process from calciol|vitamin D metabolic process|exogenous drug catabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|oxidation-reduction process|D3 vitamins binding" hsa00100 Steroid biosynthesis CYP2S1 109.9082007 104.5404647 115.2759367 1.102692025 0.141029911 0.842088433 1 2.027031295 2.331474217 29785 cytochrome P450 family 2 subfamily S member 1 "GO:0004497,GO:0004796,GO:0005506,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0006082,GO:0006690,GO:0006693,GO:0006805,GO:0008392,GO:0008395,GO:0008401,GO:0016712,GO:0016836,GO:0019373,GO:0020037,GO:0042573,GO:0042738,GO:0043231,GO:0055114,GO:0106256" "monooxygenase activity|thromboxane-A synthase activity|iron ion binding|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|organic acid metabolic process|icosanoid metabolic process|prostaglandin metabolic process|xenobiotic metabolic process|arachidonic acid epoxygenase activity|steroid hydroxylase activity|retinoic acid 4-hydroxylase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|hydro-lyase activity|epoxygenase P450 pathway|heme binding|retinoic acid metabolic process|exogenous drug catabolic process|intracellular membrane-bounded organelle|oxidation-reduction process|hydroperoxy icosatetraenoate dehydratase activity" "hsa00830,hsa00980" Retinol metabolism|Metabolism of xenobiotics by cytochrome P450 CYP2U1 345.2931162 333.9205136 356.6657188 1.068115627 0.095067832 0.839242198 1 3.546958056 3.951757186 113612 cytochrome P450 family 2 subfamily U member 1 "GO:0004497,GO:0005506,GO:0005737,GO:0005743,GO:0005789,GO:0006082,GO:0006805,GO:0008395,GO:0016021,GO:0016712,GO:0020037,GO:0042738,GO:0043231,GO:0052869,GO:0055114,GO:0097267,GO:0102033" "monooxygenase activity|iron ion binding|cytoplasm|mitochondrial inner membrane|endoplasmic reticulum membrane|organic acid metabolic process|xenobiotic metabolic process|steroid hydroxylase activity|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|heme binding|exogenous drug catabolic process|intracellular membrane-bounded organelle|arachidonic acid omega-hydroxylase activity|oxidation-reduction process|omega-hydroxylase P450 pathway|long-chain fatty acid omega-hydroxylase activity" "hsa00071,hsa00590" Fatty acid degradation|Arachidonic acid metabolism CYP39A1 61.61812016 70.03196182 53.20427849 0.759714238 -0.396471236 0.627421789 1 0.628432284 0.497994656 51302 cytochrome P450 family 39 subfamily A member 1 "GO:0005506,GO:0005789,GO:0006699,GO:0006707,GO:0007586,GO:0008387,GO:0008395,GO:0008396,GO:0016021,GO:0016125,GO:0020037,GO:0042632,GO:0043231,GO:0055114" iron ion binding|endoplasmic reticulum membrane|bile acid biosynthetic process|cholesterol catabolic process|digestion|steroid 7-alpha-hydroxylase activity|steroid hydroxylase activity|oxysterol 7-alpha-hydroxylase activity|integral component of membrane|sterol metabolic process|heme binding|cholesterol homeostasis|intracellular membrane-bounded organelle|oxidation-reduction process hsa00120 Primary bile acid biosynthesis CYP4F11 6.567522243 11.16451565 1.970528833 0.176499267 -2.5022659 0.161860904 1 0.183169204 0.033721842 57834 cytochrome P450 family 4 subfamily F member 11 "GO:0005504,GO:0005506,GO:0005515,GO:0005789,GO:0006631,GO:0006954,GO:0007596,GO:0008391,GO:0016021,GO:0016709,GO:0019369,GO:0020037,GO:0031408,GO:0036101,GO:0042361,GO:0042376,GO:0042377,GO:0043231,GO:0050051,GO:0055114,GO:0070330,GO:0102033" "fatty acid binding|iron ion binding|protein binding|endoplasmic reticulum membrane|fatty acid metabolic process|inflammatory response|blood coagulation|arachidonic acid monooxygenase activity|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|arachidonic acid metabolic process|heme binding|oxylipin biosynthetic process|leukotriene B4 catabolic process|menaquinone catabolic process|phylloquinone catabolic process|vitamin K catabolic process|intracellular membrane-bounded organelle|leukotriene-B4 20-monooxygenase activity|oxidation-reduction process|aromatase activity|long-chain fatty acid omega-hydroxylase activity" CYP4V2 210.4685137 243.5894324 177.347595 0.728059478 -0.457871781 0.389075207 1 2.649118621 2.01179718 285440 cytochrome P450 family 4 subfamily V member 2 "GO:0001523,GO:0004497,GO:0005506,GO:0005789,GO:0007601,GO:0010430,GO:0016021,GO:0016125,GO:0020037,GO:0050896,GO:0102033" retinoid metabolic process|monooxygenase activity|iron ion binding|endoplasmic reticulum membrane|visual perception|fatty acid omega-oxidation|integral component of membrane|sterol metabolic process|heme binding|response to stimulus|long-chain fatty acid omega-hydroxylase activity CYP4X1 5.508028946 6.08973581 4.926322083 0.808954975 -0.305868687 0.976518791 1 0.104338172 0.088040703 260293 cytochrome P450 family 4 subfamily X member 1 "GO:0005506,GO:0005789,GO:0016021,GO:0020037,GO:0055114,GO:0062189" "iron ion binding|endoplasmic reticulum membrane|integral component of membrane|heme binding|oxidation-reduction process|anandamide 14,15 epoxidase activity" hsa04726 Serotonergic synapse CYP51A1 1716.235111 1542.733072 1889.737151 1.224928139 0.292697115 0.370211773 1 23.72729659 30.31620255 1595 cytochrome P450 family 51 subfamily A member 1 "GO:0004497,GO:0005506,GO:0005783,GO:0005789,GO:0006694,GO:0006695,GO:0008398,GO:0016020,GO:0016021,GO:0016125,GO:0016491,GO:0020037,GO:0042177,GO:0045540,GO:0050709,GO:0055114,GO:0070988,GO:1900222" monooxygenase activity|iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|steroid biosynthetic process|cholesterol biosynthetic process|sterol 14-demethylase activity|membrane|integral component of membrane|sterol metabolic process|oxidoreductase activity|heme binding|negative regulation of protein catabolic process|regulation of cholesterol biosynthetic process|negative regulation of protein secretion|oxidation-reduction process|demethylation|negative regulation of amyloid-beta clearance hsa00100 Steroid biosynthesis CYP7B1 9.553007044 13.19442759 5.911586499 0.448036602 -1.158311499 0.436032871 1 0.024340759 0.011375318 9420 cytochrome P450 family 7 subfamily B member 1 "GO:0005506,GO:0005789,GO:0006699,GO:0008203,GO:0008395,GO:0008396,GO:0016021,GO:0016125,GO:0020037,GO:0033147,GO:0033783,GO:0035754,GO:0042632,GO:0047092,GO:0050679,GO:0055114,GO:0060740" iron ion binding|endoplasmic reticulum membrane|bile acid biosynthetic process|cholesterol metabolic process|steroid hydroxylase activity|oxysterol 7-alpha-hydroxylase activity|integral component of membrane|sterol metabolic process|heme binding|negative regulation of intracellular estrogen receptor signaling pathway|25-hydroxycholesterol 7alpha-hydroxylase activity|B cell chemotaxis|cholesterol homeostasis|27-hydroxycholesterol 7-alpha-monooxygenase activity|positive regulation of epithelial cell proliferation|oxidation-reduction process|prostate gland epithelium morphogenesis "hsa00120,hsa00140" Primary bile acid biosynthesis|Steroid hormone biosynthesis CYREN 1372.677467 1529.538644 1215.81629 0.794890861 -0.331171304 0.323585115 1 7.518755357 6.234037175 78996 cell cycle regulator of NHEJ "GO:0005515,GO:0005634,GO:0005737,GO:0006303,GO:2001033" protein binding|nucleus|cytoplasm|double-strand break repair via nonhomologous end joining|negative regulation of double-strand break repair via nonhomologous end joining CYRIA 236.7331595 355.2345889 118.23173 0.33282719 -1.587154797 0.002291302 0.152986742 3.473239138 1.205783715 81553 CYFIP related Rac1 interactor A "GO:0003674,GO:0005575,GO:0008150,GO:0016020,GO:0030833" molecular_function|cellular_component|biological_process|membrane|regulation of actin filament polymerization CYRIB 2381.278452 2586.107807 2176.449096 0.841592562 -0.24880614 0.436226897 1 29.11252216 25.55628076 51571 CYFIP related Rac1 interactor B "GO:0001916,GO:0002576,GO:0005515,GO:0005576,GO:0005739,GO:0005929,GO:0016020,GO:0023030,GO:0030334,GO:0030837,GO:0031093,GO:0031267,GO:0032729,GO:0050870,GO:0050920,GO:0051058,GO:0070062,GO:0071219,GO:0090140,GO:2000114,GO:2000568" "positive regulation of T cell mediated cytotoxicity|platelet degranulation|protein binding|extracellular region|mitochondrion|cilium|membrane|MHC class Ib protein binding, via antigen binding groove|regulation of cell migration|negative regulation of actin filament polymerization|platelet alpha granule lumen|small GTPase binding|positive regulation of interferon-gamma production|positive regulation of T cell activation|regulation of chemotaxis|negative regulation of small GTPase mediated signal transduction|extracellular exosome|cellular response to molecule of bacterial origin|regulation of mitochondrial fission|regulation of establishment of cell polarity|positive regulation of memory T cell activation" CYS1 466.5209713 572.4351662 360.6067765 0.629952172 -0.666685795 0.109327896 1 10.66267809 7.006317366 192668 cystin 1 "GO:0005515,GO:0005829,GO:0005856,GO:0005929,GO:0060170" protein binding|cytosol|cytoskeleton|cilium|ciliary membrane CYSRT1 15.43490199 11.16451565 19.70528833 1.764992674 0.819662195 0.515777845 1 0.742051616 1.366132906 375791 cysteine rich tail 1 "GO:0005515,GO:0042802,GO:0070062" protein binding|identical protein binding|extracellular exosome CYSTM1 507.7778674 631.3026123 384.2531225 0.608667088 -0.716274738 0.078942979 1 40.47246862 25.6954036 84418 cysteine rich transmembrane module containing 1 "GO:0003674,GO:0005515,GO:0005886,GO:0008150,GO:0016021,GO:0043312,GO:0070062,GO:0070821" molecular_function|protein binding|plasma membrane|biological_process|integral component of membrane|neutrophil degranulation|extracellular exosome|tertiary granule membrane CYTH1 1113.739486 1070.778547 1156.700425 1.080242435 0.111355128 0.749378071 1 12.54189545 14.13189297 9267 cytohesin 1 "GO:0000139,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0008289,GO:0016192,GO:0030155,GO:0031234,GO:0032012,GO:0050790,GO:0090162" Golgi membrane|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|plasma membrane|adherens junction|bicellular tight junction|lipid binding|vesicle-mediated transport|regulation of cell adhesion|extrinsic component of cytoplasmic side of plasma membrane|regulation of ARF protein signal transduction|regulation of catalytic activity|establishment of epithelial cell polarity "hsa04072,hsa04144,hsa05130,hsa05131,hsa05132" Phospholipase D signaling pathway|Endocytosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection CYTH2 1054.198537 974.3577296 1134.039343 1.163883971 0.218947241 0.531487149 1 25.54233006 31.0088835 9266 cytohesin 2 "GO:0000139,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0006897,GO:0008289,GO:0016020,GO:0030036,GO:0030426,GO:0032012,GO:0050790,GO:0070679" "Golgi membrane|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|plasma membrane|adherens junction|bicellular tight junction|endocytosis|lipid binding|membrane|actin cytoskeleton organization|growth cone|regulation of ARF protein signal transduction|regulation of catalytic activity|inositol 1,4,5 trisphosphate binding" "hsa04072,hsa04144,hsa05130,hsa05131,hsa05132" Phospholipase D signaling pathway|Endocytosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection CYTH3 1439.104627 1389.474721 1488.734533 1.071436933 0.099546933 0.766613451 1 12.17087389 13.60204806 9265 cytohesin 3 "GO:0000139,GO:0001726,GO:0005085,GO:0005515,GO:0005547,GO:0005654,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0031234,GO:0032012,GO:0045785,GO:0048193,GO:0050790,GO:0090162" "Golgi membrane|ruffle|guanyl-nucleotide exchange factor activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|cytosol|plasma membrane|adherens junction|bicellular tight junction|extrinsic component of cytoplasmic side of plasma membrane|regulation of ARF protein signal transduction|positive regulation of cell adhesion|Golgi vesicle transport|regulation of catalytic activity|establishment of epithelial cell polarity" "hsa04072,hsa04144,hsa05130,hsa05131,hsa05132" Phospholipase D signaling pathway|Endocytosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection CYTH4 21.18046335 33.49354696 8.867379749 0.264748901 -1.917303399 0.08767459 1 0.547910205 0.151307162 27128 cytohesin 4 "GO:0000139,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0008289,GO:0032012,GO:0034451,GO:0045171,GO:0050790" Golgi membrane|guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|lipid binding|regulation of ARF protein signal transduction|centriolar satellite|intercellular bridge|regulation of catalytic activity "hsa04072,hsa04144,hsa05130,hsa05131,hsa05132" Phospholipase D signaling pathway|Endocytosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection CYYR1 20.92808516 16.23929549 25.61687483 1.577462202 0.657605437 0.567107483 1 0.136689883 0.224911294 116159 cysteine and tyrosine rich 1 "GO:0003674,GO:0008150,GO:0016021" molecular_function|biological_process|integral component of membrane CZIB 558.197821 541.9864871 574.4091548 1.059821912 0.08382186 0.836926027 1 24.9089869 27.53625585 54987 CXXC motif containing zinc binding protein "GO:0005515,GO:0008150,GO:0008270" protein binding|biological_process|zinc ion binding D2HGDH 517.3417608 510.5228521 524.1606696 1.026713432 0.038033564 0.930117851 1 6.025677334 6.453139383 728294 D-2-hydroxyglutarate dehydrogenase "GO:0005739,GO:0005759,GO:0006103,GO:0010042,GO:0010043,GO:0032025,GO:0032026,GO:0044267,GO:0051592,GO:0051990,GO:0055114,GO:0071949" mitochondrion|mitochondrial matrix|2-oxoglutarate metabolic process|response to manganese ion|response to zinc ion|response to cobalt ion|response to magnesium ion|cellular protein metabolic process|response to calcium ion|(R)-2-hydroxyglutarate dehydrogenase activity|oxidation-reduction process|FAD binding DAAM1 315.3019346 337.9803375 292.6235317 0.86580046 -0.207893528 0.658863821 1 2.816306642 2.543394229 23002 dishevelled associated activator of morphogenesis 1 "GO:0001725,GO:0003779,GO:0005515,GO:0005829,GO:0005886,GO:0016020,GO:0030036,GO:0031514,GO:0036064,GO:0042802,GO:0060071" "stress fiber|actin binding|protein binding|cytosol|plasma membrane|membrane|actin cytoskeleton organization|motile cilium|ciliary basal body|identical protein binding|Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway DAAM2 51.23102806 33.49354696 68.96850916 2.059158119 1.042054616 0.217974604 1 0.132257134 0.284069582 23500 dishevelled associated activator of morphogenesis 2 "GO:0003779,GO:0016055,GO:0021516,GO:0030036,GO:0048715,GO:0060828,GO:0070062,GO:0090263,GO:2000050" actin binding|Wnt signaling pathway|dorsal spinal cord development|actin cytoskeleton organization|negative regulation of oligodendrocyte differentiation|regulation of canonical Wnt signaling pathway|extracellular exosome|positive regulation of canonical Wnt signaling pathway|regulation of non-canonical Wnt signaling pathway hsa04310 Wnt signaling pathway DAB2 393.6156099 336.9653815 450.2658384 1.336237676 0.418176642 0.337712002 1 3.927757844 5.474498576 1601 DAB adaptor protein 2 "GO:0000122,GO:0001650,GO:0001934,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0005905,GO:0005925,GO:0006898,GO:0006915,GO:0007229,GO:0007275,GO:0008022,GO:0010718,GO:0010862,GO:0015031,GO:0016055,GO:0030136,GO:0030335,GO:0030511,GO:0030665,GO:0032091,GO:0032436,GO:0035026,GO:0035615,GO:0038024,GO:0043066,GO:0043231,GO:0045807,GO:0045944,GO:0046332,GO:0060391,GO:0060766,GO:0061024,GO:0090090,GO:1903077,GO:2000096,GO:2000370,GO:2000643" "negative regulation of transcription by RNA polymerase II|fibrillar center|positive regulation of protein phosphorylation|protein binding|cytoplasm|lysosomal membrane|cytosol|plasma membrane|clathrin-coated pit|focal adhesion|receptor-mediated endocytosis|apoptotic process|integrin-mediated signaling pathway|multicellular organism development|protein C-terminus binding|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|protein transport|Wnt signaling pathway|clathrin-coated vesicle|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|clathrin-coated vesicle membrane|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|leading edge cell differentiation|clathrin adaptor activity|cargo receptor activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of endocytosis|positive regulation of transcription by RNA polymerase II|SMAD binding|positive regulation of SMAD protein signal transduction|negative regulation of androgen receptor signaling pathway|membrane organization|negative regulation of canonical Wnt signaling pathway|negative regulation of protein localization to plasma membrane|positive regulation of Wnt signaling pathway, planar cell polarity pathway|positive regulation of clathrin-dependent endocytosis|positive regulation of early endosome to late endosome transport" hsa04144 Endocytosis DAB2IP 1432.087772 1212.872382 1651.303162 1.361481378 0.44517725 0.182138551 1 5.132662717 7.289040472 153090 DAB2 interacting protein "GO:0000122,GO:0000165,GO:0000185,GO:0001525,GO:0001933,GO:0005096,GO:0005123,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007049,GO:0007252,GO:0007257,GO:0008285,GO:0008625,GO:0010596,GO:0010633,GO:0010719,GO:0010976,GO:0014067,GO:0016525,GO:0017124,GO:0019900,GO:0019901,GO:0021814,GO:0021819,GO:0030139,GO:0030424,GO:0030425,GO:0030948,GO:0031334,GO:0031434,GO:0031435,GO:0032088,GO:0032266,GO:0032809,GO:0034144,GO:0034260,GO:0034620,GO:0035148,GO:0035591,GO:0035662,GO:0035924,GO:0036312,GO:0036324,GO:0038026,GO:0040008,GO:0042059,GO:0042802,GO:0042803,GO:0043025,GO:0043065,GO:0043087,GO:0043122,GO:0043124,GO:0043184,GO:0043254,GO:0043407,GO:0043410,GO:0043507,GO:0043547,GO:0043548,GO:0043553,GO:0044257,GO:0044300,GO:0044301,GO:0044877,GO:0045087,GO:0045296,GO:0045732,GO:0045892,GO:0045944,GO:0046330,GO:0046580,GO:0048147,GO:0048812,GO:0050680,GO:0051721,GO:0070059,GO:0070273,GO:0070317,GO:0070373,GO:0071158,GO:0071222,GO:0071347,GO:0071356,GO:0071364,GO:0071889,GO:0071901,GO:0071902,GO:0072577,GO:0090090,GO:0090129,GO:1900006,GO:1900744,GO:1900747,GO:1901800,GO:1903363,GO:1903896,GO:1990032,GO:1990597,GO:2001224,GO:2001235" "negative regulation of transcription by RNA polymerase II|MAPK cascade|activation of MAPKKK activity|angiogenesis|negative regulation of protein phosphorylation|GTPase activator activity|death receptor binding|protein binding|cytoplasm|cytosol|plasma membrane|inflammatory response|cell cycle|I-kappaB phosphorylation|activation of JUN kinase activity|negative regulation of cell population proliferation|extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of endothelial cell migration|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|positive regulation of neuron projection development|negative regulation of phosphatidylinositol 3-kinase signaling|negative regulation of angiogenesis|SH3 domain binding|kinase binding|protein kinase binding|cell motility involved in cerebral cortex radial glia guided migration|layer formation in cerebral cortex|endocytic vesicle|axon|dendrite|negative regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of protein-containing complex assembly|mitogen-activated protein kinase kinase binding|mitogen-activated protein kinase kinase kinase binding|negative regulation of NF-kappaB transcription factor activity|phosphatidylinositol-3-phosphate binding|neuronal cell body membrane|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of GTPase activity|cellular response to unfolded protein|tube formation|signaling adaptor activity|Toll-like receptor 4 binding|cellular response to vascular endothelial growth factor stimulus|phosphatidylinositol 3-kinase regulatory subunit binding|vascular endothelial growth factor receptor-2 signaling pathway|reelin-mediated signaling pathway|regulation of growth|negative regulation of epidermal growth factor receptor signaling pathway|identical protein binding|protein homodimerization activity|neuronal cell body|positive regulation of apoptotic process|regulation of GTPase activity|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|vascular endothelial growth factor receptor 2 binding|regulation of protein-containing complex assembly|negative regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|positive regulation of GTPase activity|phosphatidylinositol 3-kinase binding|negative regulation of phosphatidylinositol 3-kinase activity|cellular protein catabolic process|cerebellar mossy fiber|climbing fiber|protein-containing complex binding|innate immune response|cadherin binding|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|negative regulation of Ras protein signal transduction|negative regulation of fibroblast proliferation|neuron projection morphogenesis|negative regulation of epithelial cell proliferation|protein phosphatase 2A binding|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|phosphatidylinositol-4-phosphate binding|negative regulation of G0 to G1 transition|negative regulation of ERK1 and ERK2 cascade|positive regulation of cell cycle arrest|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|14-3-3 protein binding|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|endothelial cell apoptotic process|negative regulation of canonical Wnt signaling pathway|positive regulation of synapse maturation|positive regulation of dendrite development|regulation of p38MAPK cascade|negative regulation of vascular endothelial growth factor signaling pathway|positive regulation of proteasomal protein catabolic process|negative regulation of cellular protein catabolic process|positive regulation of IRE1-mediated unfolded protein response|parallel fiber|AIP1-IRE1 complex|positive regulation of neuron migration|positive regulation of apoptotic signaling pathway" "hsa04210,hsa04668" Apoptosis|TNF signaling pathway DACH1 42.49726029 42.62815067 42.36636991 0.99385897 -0.008886949 1 1 0.190822472 0.197820005 1602 dachshund family transcription factor 1 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001967,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0007585,GO:0008283,GO:0010944,GO:0030336,GO:0033262,GO:0045892,GO:0046545,GO:0048147,GO:0060244,GO:2000279" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|suckling behavior|protein binding|nucleus|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|respiratory gaseous exchange by respiratory system|cell population proliferation|negative regulation of transcription by competitive promoter binding|negative regulation of cell migration|regulation of nuclear cell cycle DNA replication|negative regulation of transcription, DNA-templated|development of primary female sexual characteristics|negative regulation of fibroblast proliferation|negative regulation of cell proliferation involved in contact inhibition|negative regulation of DNA biosynthetic process" DACT1 75.57512552 81.19647747 69.95377357 0.861537049 -0.215015257 0.785987584 1 1.043999782 0.938188912 51339 dishevelled binding antagonist of beta catenin 1 "GO:0000122,GO:0001085,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008013,GO:0016055,GO:0021915,GO:0030177,GO:0030178,GO:0030877,GO:0031647,GO:0032091,GO:0032092,GO:0042826,GO:0045202,GO:0045732,GO:0046329,GO:0048619,GO:0051018,GO:0060828,GO:0070097,GO:0090090,GO:0090263,GO:1900107,GO:1903364,GO:1904864,GO:2000095,GO:2000134" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|protein kinase C binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|beta-catenin binding|Wnt signaling pathway|neural tube development|positive regulation of Wnt signaling pathway|negative regulation of Wnt signaling pathway|beta-catenin destruction complex|regulation of protein stability|negative regulation of protein binding|positive regulation of protein binding|histone deacetylase binding|synapse|positive regulation of protein catabolic process|negative regulation of JNK cascade|embryonic hindgut morphogenesis|protein kinase A binding|regulation of canonical Wnt signaling pathway|delta-catenin binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of nodal signaling pathway|positive regulation of cellular protein catabolic process|negative regulation of beta-catenin-TCF complex assembly|regulation of Wnt signaling pathway, planar cell polarity pathway|negative regulation of G1/S transition of mitotic cell cycle" DACT3 16.42016641 11.16451565 21.67581716 1.941491941 0.957165719 0.431505085 1 0.131102094 0.265497937 147906 dishevelled binding antagonist of beta catenin 3 "GO:0005080,GO:0005737,GO:0010719,GO:0016055,GO:0030178,GO:0030308,GO:0042802,GO:0051018,GO:0070097,GO:0090090" protein kinase C binding|cytoplasm|negative regulation of epithelial to mesenchymal transition|Wnt signaling pathway|negative regulation of Wnt signaling pathway|negative regulation of cell growth|identical protein binding|protein kinase A binding|delta-catenin binding|negative regulation of canonical Wnt signaling pathway DAD1 1896.762178 2096.899031 1696.625325 0.809111598 -0.305589393 0.345046592 1 155.2639452 131.0373113 1603 defender against cell death 1 "GO:0001824,GO:0005789,GO:0006486,GO:0006487,GO:0006915,GO:0007584,GO:0008047,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0031647,GO:0042493,GO:0043066,GO:0050790" blastocyst development|endoplasmic reticulum membrane|protein glycosylation|protein N-linked glycosylation|apoptotic process|response to nutrient|enzyme activator activity|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|regulation of protein stability|response to drug|negative regulation of apoptotic process|regulation of catalytic activity "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum DAG1 3816.391795 4409.983683 3222.799907 0.730796334 -0.452458699 0.155790153 1 34.65478914 26.41651668 1605 dystroglycan 1 "GO:0001618,GO:0001954,GO:0002009,GO:0002011,GO:0002162,GO:0003779,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005654,GO:0005737,GO:0005788,GO:0005796,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0006509,GO:0007411,GO:0007568,GO:0008307,GO:0009897,GO:0009925,GO:0010470,GO:0010717,GO:0014894,GO:0015631,GO:0016010,GO:0016011,GO:0016021,GO:0016203,GO:0016340,GO:0016476,GO:0017166,GO:0019048,GO:0021675,GO:0021682,GO:0022011,GO:0030027,GO:0030175,GO:0030198,GO:0030336,GO:0031103,GO:0031643,GO:0033268,GO:0034399,GO:0034453,GO:0042169,GO:0042383,GO:0043034,GO:0043231,GO:0043236,GO:0043237,GO:0043403,GO:0043409,GO:0043434,GO:0044853,GO:0045211,GO:0045860,GO:0046718,GO:0048714,GO:0050807,GO:0051393,GO:0051898,GO:0060055,GO:0060441,GO:0060445,GO:0062023,GO:0070062,GO:0070938,GO:0071260,GO:0071397,GO:0071679,GO:0071711,GO:0098696,GO:0098942,GO:0098978,GO:0098982,GO:0099524,GO:1904261" virus receptor activity|positive regulation of cell-matrix adhesion|morphogenesis of an epithelium|morphogenesis of an epithelial sheet|dystroglycan binding|actin binding|calcium ion binding|protein binding|extracellular region|basement membrane|extracellular space|nucleoplasm|cytoplasm|endoplasmic reticulum lumen|Golgi lumen|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|membrane protein ectodomain proteolysis|axon guidance|aging|structural constituent of muscle|external side of plasma membrane|basal plasma membrane|regulation of gastrulation|regulation of epithelial to mesenchymal transition|response to denervation involved in regulation of muscle adaptation|tubulin binding|dystrophin-associated glycoprotein complex|dystroglycan complex|integral component of membrane|muscle attachment|calcium-dependent cell-matrix adhesion|regulation of embryonic cell shape|vinculin binding|modulation by virus of host process|nerve development|nerve maturation|myelination in peripheral nervous system|lamellipodium|filopodium|extracellular matrix organization|negative regulation of cell migration|axon regeneration|positive regulation of myelination|node of Ranvier|nuclear periphery|microtubule anchoring|SH2 domain binding|sarcolemma|costamere|intracellular membrane-bounded organelle|laminin binding|laminin-1 binding|skeletal muscle tissue regeneration|negative regulation of MAPK cascade|response to peptide hormone|plasma membrane raft|postsynaptic membrane|positive regulation of protein kinase activity|viral entry into host cell|positive regulation of oligodendrocyte differentiation|regulation of synapse organization|alpha-actinin binding|negative regulation of protein kinase B signaling|angiogenesis involved in wound healing|epithelial tube branching involved in lung morphogenesis|branching involved in salivary gland morphogenesis|collagen-containing extracellular matrix|extracellular exosome|contractile ring|cellular response to mechanical stimulus|cellular response to cholesterol|commissural neuron axon guidance|basement membrane organization|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|retrograde trans-synaptic signaling by trans-synaptic protein complex|glutamatergic synapse|GABA-ergic synapse|postsynaptic cytosol|positive regulation of basement membrane assembly involved in embryonic body morphogenesis "hsa04512,hsa05410,hsa05412,hsa05414,hsa05416" ECM-receptor interaction|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis DAGLA 66.17057624 78.15160956 54.18954291 0.693389979 -0.528261108 0.501711288 1 0.615281101 0.445007229 747 diacylglycerol lipase alpha "GO:0005515,GO:0005886,GO:0007216,GO:0007405,GO:0016787,GO:0019369,GO:0022008,GO:0031901,GO:0032590,GO:0032591,GO:0042136,GO:0043196,GO:0045211,GO:0046340,GO:0046872,GO:0071926,GO:0098839,GO:0098921,GO:0099055,GO:0150077" protein binding|plasma membrane|G protein-coupled glutamate receptor signaling pathway|neuroblast proliferation|hydrolase activity|arachidonic acid metabolic process|neurogenesis|early endosome membrane|dendrite membrane|dendritic spine membrane|neurotransmitter biosynthetic process|varicosity|postsynaptic membrane|diacylglycerol catabolic process|metal ion binding|endocannabinoid signaling pathway|postsynaptic density membrane|retrograde trans-synaptic signaling by endocannabinoid|integral component of postsynaptic membrane|regulation of neuroinflammatory response "hsa04723,hsa04925" Retrograde endocannabinoid signaling|Aldosterone synthesis and secretion DAGLB 509.3881382 471.9545253 546.8217512 1.158632287 0.212422774 0.603574352 1 8.41945465 10.17526008 221955 diacylglycerol lipase beta "GO:0001516,GO:0004806,GO:0005515,GO:0005654,GO:0005765,GO:0005886,GO:0007216,GO:0007405,GO:0010898,GO:0016021,GO:0016042,GO:0016298,GO:0019369,GO:0022008,GO:0042136,GO:0045211,GO:0046872,GO:0050727,GO:0071926,GO:0098921" prostaglandin biosynthetic process|triglyceride lipase activity|protein binding|nucleoplasm|lysosomal membrane|plasma membrane|G protein-coupled glutamate receptor signaling pathway|neuroblast proliferation|positive regulation of triglyceride catabolic process|integral component of membrane|lipid catabolic process|lipase activity|arachidonic acid metabolic process|neurogenesis|neurotransmitter biosynthetic process|postsynaptic membrane|metal ion binding|regulation of inflammatory response|endocannabinoid signaling pathway|retrograde trans-synaptic signaling by endocannabinoid "hsa04723,hsa04925" Retrograde endocannabinoid signaling|Aldosterone synthesis and secretion DALRD3 735.0688673 711.4841338 758.6536007 1.066297286 0.09260972 0.807214824 1 17.76832417 19.76244628 55152 DALR anticodon binding domain containing 3 "GO:0004814,GO:0005515,GO:0005524,GO:0006420" arginine-tRNA ligase activity|protein binding|ATP binding|arginyl-tRNA aminoacylation DAND5 6.000661155 6.08973581 5.911586499 0.970745971 -0.042834281 1 1 0.173174416 0.175349794 199699 DAN domain BMP antagonist family member 5 "GO:0003140,GO:0003281,GO:0003283,GO:0005576,GO:0005615,GO:0016015,GO:0023019,GO:0030512,GO:0030514,GO:0035582,GO:0038101,GO:0061371,GO:1900108,GO:1900176" determination of left/right asymmetry in lateral mesoderm|ventricular septum development|atrial septum development|extracellular region|extracellular space|morphogen activity|signal transduction involved in regulation of gene expression|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|sequestering of BMP in extracellular matrix|sequestering of nodal from receptor via nodal binding|determination of heart left/right asymmetry|negative regulation of nodal signaling pathway|negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry DAP 7299.286922 8080.064464 6518.50938 0.806739774 -0.309824709 0.345730162 1 177.8473535 149.6569209 1611 death associated protein "GO:0006914,GO:0006915,GO:0006919,GO:0010507,GO:0032088,GO:0034198,GO:0045892,GO:0070513,GO:0097190" "autophagy|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of autophagy|negative regulation of NF-kappaB transcription factor activity|cellular response to amino acid starvation|negative regulation of transcription, DNA-templated|death domain binding|apoptotic signaling pathway" DAP3 2101.466325 2182.155332 2020.777318 0.926046505 -0.110843449 0.73091164 1 54.49628668 52.63997054 7818 death associated protein 3 "GO:0003723,GO:0003735,GO:0005515,GO:0005525,GO:0005654,GO:0005739,GO:0005743,GO:0005763,GO:0070125,GO:0070126,GO:0097190" RNA binding|structural constituent of ribosome|protein binding|GTP binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination|apoptotic signaling pathway DAPK2 18.43523257 14.20938356 22.66108158 1.594796952 0.673372753 0.575414843 1 0.052292919 0.086988974 23604 death associated protein kinase 2 "GO:0004674,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005794,GO:0006468,GO:0006915,GO:0010506,GO:0031410,GO:0034423,GO:0035556,GO:0042802,GO:0042981,GO:0043065,GO:0043231,GO:0043276,GO:0046777,GO:0090023,GO:0106310,GO:0106311,GO:2000424,GO:2001242" protein serine/threonine kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|Golgi apparatus|protein phosphorylation|apoptotic process|regulation of autophagy|cytoplasmic vesicle|autophagosome lumen|intracellular signal transduction|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|intracellular membrane-bounded organelle|anoikis|protein autophosphorylation|positive regulation of neutrophil chemotaxis|protein serine kinase activity|protein threonine kinase activity|positive regulation of eosinophil chemotaxis|regulation of intrinsic apoptotic signaling pathway "hsa04140,hsa05200,hsa05219" Autophagy - animal|Pathways in cancer|Bladder cancer DAPK3 896.6034888 943.9090506 849.2979271 0.899766695 -0.152377128 0.673197837 1 20.91236374 19.62677608 1613 death associated protein kinase 3 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005884,GO:0006325,GO:0006355,GO:0006468,GO:0006915,GO:0006940,GO:0007088,GO:0007346,GO:0008022,GO:0008140,GO:0008360,GO:0010506,GO:0016605,GO:0017148,GO:0030182,GO:0030335,GO:0031267,GO:0035556,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043519,GO:0043522,GO:0045121,GO:0046777,GO:0051893,GO:0071346,GO:0090263,GO:0097190,GO:0106310,GO:0106311,GO:2000145,GO:2000249,GO:2001241" "protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|actin filament|chromatin organization|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|regulation of smooth muscle contraction|regulation of mitotic nuclear division|regulation of mitotic cell cycle|protein C-terminus binding|cAMP response element binding protein binding|regulation of cell shape|regulation of autophagy|PML body|negative regulation of translation|neuron differentiation|positive regulation of cell migration|small GTPase binding|intracellular signal transduction|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|regulation of myosin II filament organization|leucine zipper domain binding|membrane raft|protein autophosphorylation|regulation of focal adhesion assembly|cellular response to interferon-gamma|positive regulation of canonical Wnt signaling pathway|apoptotic signaling pathway|protein serine kinase activity|protein threonine kinase activity|regulation of cell motility|regulation of actin cytoskeleton reorganization|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04140,hsa05200,hsa05219" Autophagy - animal|Pathways in cancer|Bladder cancer DAPP1 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.015145533 0.061343151 27071 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 "GO:0005515,GO:0005543,GO:0005547,GO:0005829,GO:0005886,GO:0006470,GO:0007165,GO:0043325" "protein binding|phospholipid binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|plasma membrane|protein dephosphorylation|signal transduction|phosphatidylinositol-3,4-bisphosphate binding" hsa04662 B cell receptor signaling pathway DARS1 1556.068777 1740.649486 1371.488068 0.787917429 -0.343883646 0.297577398 1 28.44716225 23.37951981 1615 aspartyl-tRNA synthetase 1 "GO:0003723,GO:0004046,GO:0004815,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006422,GO:0016020,GO:0017101,GO:0045202,GO:0065003,GO:0070062" RNA binding|aminoacylase activity|aspartate-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|aspartyl-tRNA aminoacylation|membrane|aminoacyl-tRNA synthetase multienzyme complex|synapse|protein-containing complex assembly|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis DARS2 1718.733161 1848.234818 1589.231504 0.859864498 -0.217818765 0.505039766 1 26.60033344 23.85794475 55157 "aspartyl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0004815,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0006418,GO:0042803,GO:0043039,GO:0050560,GO:0070145" tRNA binding|aspartate-tRNA ligase activity|protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|protein homodimerization activity|tRNA aminoacylation|aspartate-tRNA(Asn) ligase activity|mitochondrial asparaginyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis DAW1 36.68959422 49.73284245 23.646346 0.475467414 -1.072581625 0.251822055 1 1.295009266 0.642258061 164781 dynein assembly factor with WD repeats 1 "GO:0005515,GO:0005575,GO:0005576,GO:0005929,GO:0007368,GO:0007507,GO:0008150,GO:0036158,GO:0051649,GO:0090660" protein binding|cellular_component|extracellular region|cilium|determination of left/right symmetry|heart development|biological_process|outer dynein arm assembly|establishment of localization in cell|cerebrospinal fluid circulation DAXX 1302.90877 1272.754784 1333.062756 1.04738381 0.06679021 0.845225838 1 25.24893843 27.58448688 1616 death domain associated protein "GO:0000775,GO:0001934,GO:0002039,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006334,GO:0006338,GO:0006355,GO:0007257,GO:0008134,GO:0008625,GO:0016032,GO:0016604,GO:0016605,GO:0019899,GO:0019901,GO:0030295,GO:0030521,GO:0031072,GO:0031396,GO:0031625,GO:0034605,GO:0034620,GO:0042393,GO:0042981,GO:0045860,GO:0045892,GO:0045893,GO:0047485,GO:0050681,GO:0071276,GO:0071280,GO:0072738,GO:0140037,GO:0140416,GO:1901216,GO:1903936" "chromosome, centromeric region|positive regulation of protein phosphorylation|p53 binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|nucleosome assembly|chromatin remodeling|regulation of transcription, DNA-templated|activation of JUN kinase activity|transcription factor binding|extrinsic apoptotic signaling pathway via death domain receptors|viral process|nuclear body|PML body|enzyme binding|protein kinase binding|protein kinase activator activity|androgen receptor signaling pathway|heat shock protein binding|regulation of protein ubiquitination|ubiquitin protein ligase binding|cellular response to heat|cellular response to unfolded protein|histone binding|regulation of apoptotic process|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein N-terminus binding|androgen receptor binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to diamide|sumo-dependent protein binding|transcription regulator inhibitor activity|positive regulation of neuron death|cellular response to sodium arsenite" "hsa04010,hsa04210,hsa05012,hsa05014,hsa05022,hsa05168" MAPK signaling pathway|Apoptosis|Parkinson disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Herpes simplex virus 1 infection DAZAP1 2108.079869 1994.388478 2221.771259 1.114011279 0.15576384 0.628261617 1 21.61539495 25.11705364 26528 DAZ associated protein 1 "GO:0001893,GO:0003723,GO:0003730,GO:0005515,GO:0005654,GO:0005829,GO:0007283,GO:0008266,GO:0008283,GO:0030154,GO:0032991,GO:0034046,GO:0035613,GO:0048026,GO:1990904" "maternal placenta development|RNA binding|mRNA 3'-UTR binding|protein binding|nucleoplasm|cytosol|spermatogenesis|poly(U) RNA binding|cell population proliferation|cell differentiation|protein-containing complex|poly(G) binding|RNA stem-loop binding|positive regulation of mRNA splicing, via spliceosome|ribonucleoprotein complex" hsa03015 mRNA surveillance pathway DAZAP2 5283.131576 5028.091867 5538.171285 1.101445923 0.139398665 0.665261191 1 94.87895493 109.0056482 9802 DAZ associated protein 2 "GO:0005515,GO:0005737,GO:0016607,GO:0030971,GO:0031435,GO:0032991,GO:0042802,GO:0043539,GO:0050699,GO:0071902" protein binding|cytoplasm|nuclear speck|receptor tyrosine kinase binding|mitogen-activated protein kinase kinase kinase binding|protein-containing complex|identical protein binding|protein serine/threonine kinase activator activity|WW domain binding|positive regulation of protein serine/threonine kinase activity DBF4 536.0293716 541.9864871 530.0722561 0.978017476 -0.03206785 0.941226181 1 7.704098669 7.859309311 10926 DBF4 zinc finger "GO:0000082,GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0008047,GO:0008270,GO:0010571,GO:0016604,GO:0031431,GO:0043539,GO:0071902,GO:1901987" G1/S transition of mitotic cell cycle|nucleic acid binding|protein binding|nucleus|nucleoplasm|DNA replication|enzyme activator activity|zinc ion binding|positive regulation of nuclear cell cycle DNA replication|nuclear body|Dbf4-dependent protein kinase complex|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity|regulation of cell cycle phase transition hsa04110 Cell cycle DBF4B 769.6624855 651.6017317 887.7232393 1.362370903 0.446119527 0.228419114 1 7.931105263 11.27054722 80174 DBF4 zinc finger B "GO:0000785,GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007049,GO:0008270,GO:0008284,GO:0010571,GO:0010971,GO:0019901,GO:0030295,GO:0031431,GO:0032147,GO:0043231,GO:0043539,GO:0071902,GO:1901987" chromatin|nucleic acid binding|protein binding|nucleus|nucleoplasm|cytoplasm|cell cycle|zinc ion binding|positive regulation of cell population proliferation|positive regulation of nuclear cell cycle DNA replication|positive regulation of G2/M transition of mitotic cell cycle|protein kinase binding|protein kinase activator activity|Dbf4-dependent protein kinase complex|activation of protein kinase activity|intracellular membrane-bounded organelle|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity|regulation of cell cycle phase transition DBI 1110.463766 1149.945112 1070.982421 0.931333513 -0.102630202 0.768755322 1 43.59331075 42.34879076 1622 "diazepam binding inhibitor, acyl-CoA binding protein" "GO:0005788,GO:0005794,GO:0006637,GO:0008289,GO:0030156,GO:0032994,GO:0036042,GO:0036151,GO:0042802,GO:0070062,GO:1903060,GO:1905920,GO:2001140" endoplasmic reticulum lumen|Golgi apparatus|acyl-CoA metabolic process|lipid binding|benzodiazepine receptor binding|protein-lipid complex|long-chain fatty acyl-CoA binding|phosphatidylcholine acyl-chain remodeling|identical protein binding|extracellular exosome|negative regulation of protein lipidation|positive regulation of CoA-transferase activity|positive regulation of phospholipid transport hsa03320 PPAR signaling pathway DBN1 2991.813807 3506.672871 2476.954743 0.706354666 -0.501535342 0.115400305 1 39.24875361 28.91775791 1627 drebrin 1 "GO:0001701,GO:0003779,GO:0005515,GO:0005522,GO:0005737,GO:0005856,GO:0005884,GO:0005886,GO:0005921,GO:0007015,GO:0010643,GO:0010644,GO:0014069,GO:0015629,GO:0030027,GO:0030425,GO:0030426,GO:0030427,GO:0030833,GO:0030863,GO:0030864,GO:0031915,GO:0032507,GO:0042641,GO:0045211,GO:0045296,GO:0045773,GO:0048168,GO:0048812,GO:0050773,GO:0051015,GO:0051220,GO:0061003,GO:0061351,GO:0098974,GO:0098978,GO:0099524,GO:1902685" in utero embryonic development|actin binding|protein binding|profilin binding|cytoplasm|cytoskeleton|actin filament|plasma membrane|gap junction|actin filament organization|cell communication by chemical coupling|cell communication by electrical coupling|postsynaptic density|actin cytoskeleton|lamellipodium|dendrite|growth cone|site of polarized growth|regulation of actin filament polymerization|cortical cytoskeleton|cortical actin cytoskeleton|positive regulation of synaptic plasticity|maintenance of protein location in cell|actomyosin|postsynaptic membrane|cadherin binding|positive regulation of axon extension|regulation of neuronal synaptic plasticity|neuron projection morphogenesis|regulation of dendrite development|actin filament binding|cytoplasmic sequestering of protein|positive regulation of dendritic spine morphogenesis|neural precursor cell proliferation|postsynaptic actin cytoskeleton organization|glutamatergic synapse|postsynaptic cytosol|positive regulation of receptor localization to synapse DBNDD1 304.8527378 330.8756457 278.8298299 0.84270279 -0.246904193 0.602809289 1 6.502787813 5.715970054 79007 dysbindin domain containing 1 "GO:0005737,GO:0006469" cytoplasm|negative regulation of protein kinase activity DBNDD2 1655.220225 1581.301399 1729.139051 1.093491129 0.128941516 0.695015665 1 43.7157955 49.86198679 55861 dysbindin domain containing 2 "GO:0005515,GO:0005737,GO:0006469" protein binding|cytoplasm|negative regulation of protein kinase activity DBNL 3041.622362 3409.237098 2674.007627 0.784341936 -0.350445356 0.27080179 1 17.44804284 14.27473598 28988 drebrin like "GO:0000139,GO:0001726,GO:0002102,GO:0002250,GO:0003779,GO:0005515,GO:0005576,GO:0005737,GO:0005769,GO:0005829,GO:0005884,GO:0005886,GO:0005938,GO:0006898,GO:0007257,GO:0007416,GO:0008022,GO:0008047,GO:0014069,GO:0016601,GO:0019904,GO:0030027,GO:0030425,GO:0030427,GO:0030665,GO:0030833,GO:0030864,GO:0034774,GO:0043204,GO:0043312,GO:0045211,GO:0045296,GO:0045773,GO:0048812,GO:0051015,GO:0061003,GO:0070062,GO:0071800,GO:0097178,GO:0098974,GO:1904724,GO:1904813" Golgi membrane|ruffle|podosome|adaptive immune response|actin binding|protein binding|extracellular region|cytoplasm|early endosome|cytosol|actin filament|plasma membrane|cell cortex|receptor-mediated endocytosis|activation of JUN kinase activity|synapse assembly|protein C-terminus binding|enzyme activator activity|postsynaptic density|Rac protein signal transduction|protein domain specific binding|lamellipodium|dendrite|site of polarized growth|clathrin-coated vesicle membrane|regulation of actin filament polymerization|cortical actin cytoskeleton|secretory granule lumen|perikaryon|neutrophil degranulation|postsynaptic membrane|cadherin binding|positive regulation of axon extension|neuron projection morphogenesis|actin filament binding|positive regulation of dendritic spine morphogenesis|extracellular exosome|podosome assembly|ruffle assembly|postsynaptic actin cytoskeleton organization|tertiary granule lumen|ficolin-1-rich granule lumen DBP 61.38058774 53.79266632 68.96850916 1.28211732 0.358528281 0.663304145 1 1.255487917 1.67902141 1628 D-box binding PAR bZIP transcription factor "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001889,GO:0005634,GO:0006357,GO:0007623,GO:0045944,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|nucleus|regulation of transcription by RNA polymerase II|circadian rhythm|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TF_bZIP DBR1 285.464654 285.2026271 285.7266808 1.001837478 0.002648489 1 1 5.426185924 5.670323995 51163 debranching RNA lariats 1 "GO:0000375,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0008419,GO:0046872,GO:0090502" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|RNA lariat debranching enzyme activity|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" DBT 640.3107772 632.3175683 648.3039861 1.025282261 0.036021139 0.929656246 1 2.920358759 3.123169681 1629 dihydrolipoamide branched chain transacylase E2 "GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005947,GO:0009083,GO:0015630,GO:0016407,GO:0031405,GO:0031625,GO:0042645,GO:0043754" cytoplasm|mitochondrion|mitochondrial matrix|cytosol|mitochondrial alpha-ketoglutarate dehydrogenase complex|branched-chain amino acid catabolic process|microtubule cytoskeleton|acetyltransferase activity|lipoic acid binding|ubiquitin protein ligase binding|mitochondrial nucleoid|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity "hsa00280,hsa00640" "Valine, leucine and isoleucine degradation|Propanoate metabolism" DCAF1 1652.384436 1757.903737 1546.865134 0.879948715 -0.184508652 0.574137406 1 9.419342232 8.645574695 9730 DDB1 and CUL4 associated factor 1 "GO:0000122,GO:0001650,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0008180,GO:0016032,GO:0016567,GO:0030183,GO:0030331,GO:0033151,GO:0035212,GO:0080008,GO:0106310,GO:0106311,GO:1990244,GO:1990245" negative regulation of transcription by RNA polymerase II|fibrillar center|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|COP9 signalosome|viral process|protein ubiquitination|B cell differentiation|estrogen receptor binding|V(D)J recombination|cell competition in a multicellular organism|Cul4-RING E3 ubiquitin ligase complex|protein serine kinase activity|protein threonine kinase activity|histone kinase activity (H2A-T120 specific)|histone H2A-T120 phosphorylation hsa05170 Human immunodeficiency virus 1 infection DCAF10 1563.054948 1376.280293 1749.829604 1.271419501 0.346440122 0.293770983 1 8.541078498 11.3270681 79269 DDB1 and CUL4 associated factor 10 "GO:0005515,GO:0005654,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF11 1181.494601 1122.541301 1240.4479 1.105035422 0.144092616 0.675594126 1 14.10038611 16.25261077 80344 DDB1 and CUL4 associated factor 11 "GO:0005515,GO:0005654,GO:0016567,GO:0043161,GO:0043687,GO:0080008" protein binding|nucleoplasm|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF12 1423.200103 1278.84452 1567.555687 1.225759396 0.293675821 0.379146861 1 16.87131114 21.57098592 25853 DDB1 and CUL4 associated factor 12 "GO:0005515,GO:0005737,GO:0005813,GO:0016567,GO:0080008" protein binding|cytoplasm|centrosome|protein ubiquitination|Cul4-RING E3 ubiquitin ligase complex DCAF13 1604.531563 1854.324554 1354.738573 0.730583311 -0.452879297 0.168738745 1 47.67258731 36.32908 25879 DDB1 and CUL4 associated factor 13 "GO:0000462,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0006364,GO:0016567,GO:0030054,GO:0030331,GO:0032040,GO:0043687,GO:0080008" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|nucleolus|centrosome|cytosol|rRNA processing|protein ubiquitination|cell junction|estrogen receptor binding|small-subunit processome|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex" DCAF15 762.5253806 668.8559832 856.194778 1.280088389 0.356243431 0.337197784 1 14.98239538 20.00493488 90379 DDB1 and CUL4 associated factor 15 "GO:0000209,GO:0002376,GO:0005515,GO:0016567,GO:0032814,GO:0036094,GO:0046872,GO:0080008" protein polyubiquitination|immune system process|protein binding|protein ubiquitination|regulation of natural killer cell activation|small molecule binding|metal ion binding|Cul4-RING E3 ubiquitin ligase complex DCAF16 1013.06585 856.6228373 1169.508862 1.365255293 0.44917075 0.201598971 1 7.775076116 11.07221341 54876 DDB1 and CUL4 associated factor 16 "GO:0005515,GO:0005654,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF17 279.823013 269.9782876 289.6677385 1.072929757 0.101555628 0.840040876 1 2.049377674 2.293555325 80067 DDB1 and CUL4 associated factor 17 "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0016021,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleoplasm|nucleolus|cytosol|integral component of membrane|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF4 659.1386809 774.4114039 543.8659579 0.702295905 -0.509849071 0.182944525 1 13.4089592 9.822705766 26094 DDB1 and CUL4 associated factor 4 "GO:0005515,GO:0005654,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF5 1563.546097 1578.256531 1548.835663 0.981358627 -0.027147644 0.936399249 1 9.670109549 9.898629488 8816 DDB1 and CUL4 associated factor 5 "GO:0005515,GO:0005654,GO:0005737,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleoplasm|cytoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF6 1375.267559 1437.177651 1313.357467 0.9138449 -0.129978766 0.699490908 1 20.04626218 19.1082902 55827 DDB1 and CUL4 associated factor 6 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005925,GO:0016567,GO:0030374,GO:0043687,GO:0045944,GO:0080008" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|focal adhesion|protein ubiquitination|nuclear receptor coactivator activity|post-translational protein modification|positive regulation of transcription by RNA polymerase II|Cul4-RING E3 ubiquitin ligase complex DCAF7 4602.347016 3885.251447 5319.442585 1.369137277 0.453267106 0.157119164 1 31.11547746 44.43645388 10238 DDB1 and CUL4 associated factor 7 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007275,GO:0016363,GO:0016567,GO:0016604,GO:0030674,GO:0032991,GO:0043687,GO:0080008" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|multicellular organism development|nuclear matrix|protein ubiquitination|nuclear body|protein-macromolecule adaptor activity|protein-containing complex|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF8 2158.726468 2055.285836 2262.1671 1.100658147 0.138366453 0.66684701 1 26.91827695 30.9040672 50717 DDB1 and CUL4 associated factor 8 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAKD 315.8445473 274.0381115 357.6509832 1.305114027 0.38417586 0.410218025 1 4.151679209 5.651818105 79877 dephospho-CoA kinase domain containing "GO:0004140,GO:0005524,GO:0015937,GO:0016020,GO:0016310" dephospho-CoA kinase activity|ATP binding|coenzyme A biosynthetic process|membrane|phosphorylation DCBLD1 822.9367874 892.1462962 753.7272787 0.844847176 -0.243237699 0.506375226 1 10.61905114 9.357930138 285761 "discoidin, CUB and LCCL domain containing 1" GO:0016021 integral component of membrane DCBLD2 22230.60648 23749.96966 20711.2433 0.872053464 -0.197511509 0.593038207 1 192.3332553 174.9497891 131566 "discoidin, CUB and LCCL domain containing 2" "GO:0005515,GO:0005887,GO:0009986,GO:0030308,GO:0030522,GO:0042060" protein binding|integral component of plasma membrane|cell surface|negative regulation of cell growth|intracellular receptor signaling pathway|wound healing DCDC1 10.97152057 9.134603715 12.80843742 1.402188624 0.487680435 0.768959523 1 0.0277976 0.04065647 341019 doublecortin domain containing 1 "GO:0005515,GO:0005737,GO:0005874,GO:0007049,GO:0008017,GO:0030246,GO:0030496,GO:0035556,GO:0051301,GO:0072686,GO:0090543,GO:1902412" protein binding|cytoplasm|microtubule|cell cycle|microtubule binding|carbohydrate binding|midbody|intracellular signal transduction|cell division|mitotic spindle|Flemming body|regulation of mitotic cytokinesis DCDC2 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.031947756 0.010783025 51473 doublecortin domain containing 2 "GO:0001764,GO:0005515,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005874,GO:0005929,GO:0005930,GO:0006968,GO:0007605,GO:0015630,GO:0019894,GO:0030111,GO:0030864,GO:0034451,GO:0035556,GO:0045880,GO:0048813,GO:0060091,GO:0060271,GO:0072686,GO:1902017" neuron migration|protein binding|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|microtubule|cilium|axoneme|cellular defense response|sensory perception of sound|microtubule cytoskeleton|kinesin binding|regulation of Wnt signaling pathway|cortical actin cytoskeleton|centriolar satellite|intracellular signal transduction|positive regulation of smoothened signaling pathway|dendrite morphogenesis|kinocilium|cilium assembly|mitotic spindle|regulation of cilium assembly DCHS1 85.01208796 52.77771036 117.2464656 2.221514817 1.151543764 0.109436969 1 0.249510393 0.578167645 8642 dachsous cadherin-related 1 "GO:0000902,GO:0001658,GO:0003192,GO:0003273,GO:0005509,GO:0005912,GO:0007043,GO:0007156,GO:0007157,GO:0007275,GO:0007389,GO:0016020,GO:0016021,GO:0016339,GO:0016342,GO:0021915,GO:0022008,GO:0034332,GO:0035329,GO:0036342,GO:0043931,GO:0045177,GO:0045296,GO:0048565,GO:0072137,GO:0072659,GO:0090102,GO:0098742" cell morphogenesis|branching involved in ureteric bud morphogenesis|mitral valve formation|cell migration involved in endocardial cushion formation|calcium ion binding|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|multicellular organism development|pattern specification process|membrane|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|neural tube development|neurogenesis|adherens junction organization|hippo signaling|post-anal tail morphogenesis|ossification involved in bone maturation|apical part of cell|cadherin binding|digestive tract development|condensed mesenchymal cell proliferation|protein localization to plasma membrane|cochlea development|cell-cell adhesion via plasma-membrane adhesion molecules hsa04392 Hippo signaling pathway - multiple species DCHS2 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.009921625 0.006697505 54798 dachsous cadherin-related 2 "GO:0003674,GO:0005509,GO:0005575,GO:0005886,GO:0007156,GO:0008150,GO:0016021,GO:0072006,GO:0072137" molecular_function|calcium ion binding|cellular_component|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|biological_process|integral component of membrane|nephron development|condensed mesenchymal cell proliferation hsa04392 Hippo signaling pathway - multiple species DCK 895.3943 760.2020203 1030.58658 1.355674613 0.439010947 0.222135785 1 15.36374721 21.72543824 1633 deoxycytidine kinase "GO:0004136,GO:0004137,GO:0004138,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006170,GO:0006220,GO:0008144,GO:0016310,GO:0019136,GO:0042803,GO:0043097,GO:0043101" deoxyadenosine kinase activity|deoxycytidine kinase activity|deoxyguanosine kinase activity|ATP binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|dAMP biosynthetic process|pyrimidine nucleotide metabolic process|drug binding|phosphorylation|deoxynucleoside kinase activity|protein homodimerization activity|pyrimidine nucleoside salvage|purine-containing compound salvage "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism DCLK1 8.478667972 7.104691779 9.852644165 1.386779958 0.471738892 0.817532793 1 0.026395802 0.038181972 9201 doublecortin like kinase 1 "GO:0001764,GO:0004672,GO:0005524,GO:0005887,GO:0006468,GO:0007399,GO:0007417,GO:0009615,GO:0014069,GO:0016197,GO:0018105,GO:0021952,GO:0030900,GO:0035556,GO:0048675,GO:0048812,GO:0048813,GO:0106310,GO:0106311,GO:1900181" neuron migration|protein kinase activity|ATP binding|integral component of plasma membrane|protein phosphorylation|nervous system development|central nervous system development|response to virus|postsynaptic density|endosomal transport|peptidyl-serine phosphorylation|central nervous system projection neuron axonogenesis|forebrain development|intracellular signal transduction|axon extension|neuron projection morphogenesis|dendrite morphogenesis|protein serine kinase activity|protein threonine kinase activity|negative regulation of protein localization to nucleus DCLK2 53.82780108 42.62815067 65.02745149 1.525457954 0.609242415 0.468087656 1 0.467005288 0.743084102 166614 doublecortin like kinase 2 "GO:0000226,GO:0005524,GO:0005737,GO:0005856,GO:0006468,GO:0035556,GO:0106310,GO:0106311" microtubule cytoskeleton organization|ATP binding|cytoplasm|cytoskeleton|protein phosphorylation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity DCLRE1A 331.1997772 347.1149412 315.2846133 0.908300323 -0.138758701 0.767012316 1 3.765291759 3.567336129 9937 DNA cross-link repair 1A "GO:0001650,GO:0003684,GO:0005654,GO:0006303,GO:0007049,GO:0031848,GO:0035312,GO:0036297,GO:0046872,GO:0051301,GO:0090305" fibrillar center|damaged DNA binding|nucleoplasm|double-strand break repair via nonhomologous end joining|cell cycle|protection from non-homologous end joining at telomere|5'-3' exodeoxyribonuclease activity|interstrand cross-link repair|metal ion binding|cell division|nucleic acid phosphodiester bond hydrolysis DCLRE1B 874.831916 836.3237179 913.3401141 1.092089217 0.12709072 0.726832538 1 11.94496501 13.60689178 64858 DNA cross-link repair 1B "GO:0000723,GO:0000781,GO:0003684,GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0006303,GO:0007093,GO:0008409,GO:0010833,GO:0016233,GO:0016604,GO:0031627,GO:0031848,GO:0031860,GO:0035312,GO:0036297,GO:0042803,GO:0044877,GO:0090305" "telomere maintenance|chromosome, telomeric region|damaged DNA binding|protein binding|nucleoplasm|cytoplasm|centrosome|double-strand break repair via nonhomologous end joining|mitotic cell cycle checkpoint|5'-3' exonuclease activity|telomere maintenance via telomere lengthening|telomere capping|nuclear body|telomeric loop formation|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|5'-3' exodeoxyribonuclease activity|interstrand cross-link repair|protein homodimerization activity|protein-containing complex binding|nucleic acid phosphodiester bond hydrolysis" DCLRE1C 530.3310692 489.2087768 571.4533616 1.168117558 0.224185473 0.579555254 1 2.870996375 3.498123401 64421 DNA cross-link repair 1C "GO:0000014,GO:0002250,GO:0003684,GO:0004519,GO:0005515,GO:0005654,GO:0005794,GO:0006303,GO:0008409,GO:0010212,GO:0030183,GO:0031848,GO:0033151,GO:0035312,GO:0036297,GO:0070419,GO:0090305" single-stranded DNA endodeoxyribonuclease activity|adaptive immune response|damaged DNA binding|endonuclease activity|protein binding|nucleoplasm|Golgi apparatus|double-strand break repair via nonhomologous end joining|5'-3' exonuclease activity|response to ionizing radiation|B cell differentiation|protection from non-homologous end joining at telomere|V(D)J recombination|5'-3' exodeoxyribonuclease activity|interstrand cross-link repair|nonhomologous end joining complex|nucleic acid phosphodiester bond hydrolysis "hsa03450,hsa05340" Non-homologous end-joining|Primary immunodeficiency DCN 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.036565613 0.022214965 1634 decorin "GO:0001822,GO:0001890,GO:0003723,GO:0005515,GO:0005518,GO:0005539,GO:0005576,GO:0005589,GO:0005615,GO:0005796,GO:0007519,GO:0007568,GO:0009612,GO:0009887,GO:0010508,GO:0010596,GO:0014068,GO:0016239,GO:0016525,GO:0019800,GO:0030021,GO:0030198,GO:0030206,GO:0030207,GO:0030208,GO:0032496,GO:0042060,GO:0043202,GO:0045944,GO:0047485,GO:0050840,GO:0051901,GO:0062023,GO:0090141,GO:1900747" kidney development|placenta development|RNA binding|protein binding|collagen binding|glycosaminoglycan binding|extracellular region|collagen type VI trimer|extracellular space|Golgi lumen|skeletal muscle tissue development|aging|response to mechanical stimulus|animal organ morphogenesis|positive regulation of autophagy|negative regulation of endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of macroautophagy|negative regulation of angiogenesis|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix structural constituent conferring compression resistance|extracellular matrix organization|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|response to lipopolysaccharide|wound healing|lysosomal lumen|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|extracellular matrix binding|positive regulation of mitochondrial depolarization|collagen-containing extracellular matrix|positive regulation of mitochondrial fission|negative regulation of vascular endothelial growth factor signaling pathway "hsa04350,hsa05205" TGF-beta signaling pathway|Proteoglycans in cancer DCP1A 892.8472614 1057.584119 728.1104038 0.688465712 -0.538543289 0.134541537 1 8.955509897 6.431148885 55802 decapping mRNA 1A "GO:0000184,GO:0000290,GO:0000932,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008047,GO:0016020,GO:0016787,GO:0019894,GO:0030234,GO:0031087,GO:0036464,GO:0042802,GO:0043085,GO:0043488,GO:0043928,GO:1903608" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|enzyme activator activity|membrane|hydrolase activity|kinesin binding|enzyme regulator activity|deadenylation-independent decapping of nuclear-transcribed mRNA|cytoplasmic ribonucleoprotein granule|identical protein binding|positive regulation of catalytic activity|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|protein localization to cytoplasmic stress granule" hsa03018 RNA degradation DCP1B 248.4605768 247.6492563 249.2718974 1.006552174 0.009421956 0.994186367 1 3.161724521 3.31952733 196513 decapping mRNA 1B "GO:0000184,GO:0000290,GO:0000932,GO:0003729,GO:0005515,GO:0005634,GO:0005829,GO:0008047,GO:0016020,GO:0016787,GO:0030234,GO:0031087,GO:0043085,GO:0043231,GO:0043928" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|mRNA binding|protein binding|nucleus|cytosol|enzyme activator activity|membrane|hydrolase activity|enzyme regulator activity|deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of catalytic activity|intracellular membrane-bounded organelle|exonucleolytic catabolism of deadenylated mRNA" hsa03018 RNA degradation DCP2 947.5512094 789.6357434 1105.466675 1.39997041 0.485396334 0.172651623 1 3.886517467 5.675386072 167227 decapping mRNA 2 "GO:0000184,GO:0000290,GO:0000932,GO:0004534,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006402,GO:0016442,GO:0016896,GO:0030054,GO:0030145,GO:0032211,GO:0036464,GO:0043488,GO:0043928,GO:0050072,GO:0070034,GO:0071044,GO:0090503,GO:1904872" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|5'-3' exoribonuclease activity|protein binding|nucleoplasm|cytoplasm|cytosol|mRNA catabolic process|RISC complex|exoribonuclease activity, producing 5'-phosphomonoesters|cell junction|manganese ion binding|negative regulation of telomere maintenance via telomerase|cytoplasmic ribonucleoprotein granule|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|m7G(5')pppN diphosphatase activity|telomerase RNA binding|histone mRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic|regulation of telomerase RNA localization to Cajal body" hsa03018 RNA degradation DCPS 571.47588 641.452172 501.499588 0.781819144 -0.355093183 0.369707409 1 5.986233574 4.881753976 28960 "decapping enzyme, scavenger" "GO:0000288,GO:0000290,GO:0000340,GO:0000932,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0036245,GO:0042802,GO:0043069,GO:0043928,GO:0045292,GO:0050072,GO:0090503" "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|RNA 7-methylguanosine cap binding|P-body|exoribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|cellular response to menadione|identical protein binding|negative regulation of programmed cell death|exonucleolytic catabolism of deadenylated mRNA|mRNA cis splicing, via spliceosome|m7G(5')pppN diphosphatase activity|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation DCST1 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.022378728 0.113299224 149095 DC-STAMP domain containing 1 "GO:0005515,GO:0005886,GO:0006511,GO:0016021,GO:0016567,GO:0045087,GO:0046872,GO:0060339,GO:0061630" protein binding|plasma membrane|ubiquitin-dependent protein catabolic process|integral component of membrane|protein ubiquitination|innate immune response|metal ion binding|negative regulation of type I interferon-mediated signaling pathway|ubiquitin protein ligase activity DCST2 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.079968792 0.080973341 127579 DC-STAMP domain containing 2 GO:0016021 integral component of membrane DCTD 1939.71446 1867.518982 2011.909939 1.077316996 0.107442819 0.740371478 1 34.95315899 39.27768414 1635 dCMP deaminase "GO:0004132,GO:0005515,GO:0005829,GO:0006220,GO:0006226,GO:0006231,GO:0008270,GO:0015949,GO:0042802" dCMP deaminase activity|protein binding|cytosol|pyrimidine nucleotide metabolic process|dUMP biosynthetic process|dTMP biosynthetic process|zinc ion binding|nucleobase-containing small molecule interconversion|identical protein binding hsa00240 Pyrimidine metabolism DCTN1 3982.106736 4086.212729 3878.000744 0.949045241 -0.075451233 0.813402169 1 42.62662398 42.19721449 1639 dynactin subunit 1 "GO:0000086,GO:0000132,GO:0000278,GO:0000776,GO:0000922,GO:0003774,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005874,GO:0005875,GO:0005938,GO:0006888,GO:0007097,GO:0007399,GO:0007528,GO:0008017,GO:0010389,GO:0010457,GO:0015630,GO:0015631,GO:0016020,GO:0019886,GO:0019901,GO:0021517,GO:0030286,GO:0030424,GO:0030904,GO:0031116,GO:0031122,GO:0034454,GO:0035371,GO:0036498,GO:0042147,GO:0043005,GO:0043025,GO:0045171,GO:0048156,GO:0050905,GO:0051010,GO:0051081,GO:0051301,GO:0060236,GO:0061744,GO:0070050,GO:0072686,GO:0090063,GO:0097711,GO:0098930,GO:0099558,GO:0099738,GO:0120103,GO:1904398,GO:1905515,GO:1990535" "G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|mitotic cell cycle|kinetochore|spindle pole|motor activity|protein binding|nucleus|nuclear envelope|cytoplasm|centrosome|centriole|spindle|cytosol|microtubule|microtubule associated complex|cell cortex|endoplasmic reticulum to Golgi vesicle-mediated transport|nuclear migration|nervous system development|neuromuscular junction development|microtubule binding|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|microtubule cytoskeleton|tubulin binding|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|ventral spinal cord development|dynein complex|axon|retromer complex|positive regulation of microtubule polymerization|cytoplasmic microtubule organization|microtubule anchoring at centrosome|microtubule plus-end|IRE1-mediated unfolded protein response|retrograde transport, endosome to Golgi|neuron projection|neuronal cell body|intercellular bridge|tau protein binding|neuromuscular process|microtubule plus-end binding|nuclear envelope disassembly|cell division|regulation of mitotic spindle organization|motor behavior|neuron cellular homeostasis|mitotic spindle|positive regulation of microtubule nucleation|ciliary basal body-plasma membrane docking|axonal transport|maintenance of synapse structure|cell cortex region|centriolar subdistal appendage|positive regulation of neuromuscular junction development|non-motile cilium assembly|neuron projection maintenance" "hsa04962,hsa05014,hsa05016,hsa05022,hsa05132" Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTN2 3348.027718 3004.269666 3691.785769 1.228846335 0.297304521 0.350058952 1 61.05764855 78.26247589 10540 dynactin subunit 2 "GO:0000086,GO:0000776,GO:0003774,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005869,GO:0005874,GO:0006888,GO:0007052,GO:0007080,GO:0010389,GO:0016020,GO:0019886,GO:0019901,GO:0030286,GO:0030426,GO:0030507,GO:0031982,GO:0032402,GO:0042802,GO:0070062,GO:0071539,GO:0097711" G2/M transition of mitotic cell cycle|kinetochore|motor activity|protein binding|cytoplasm|centrosome|cytosol|dynactin complex|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|mitotic spindle organization|mitotic metaphase plate congression|regulation of G2/M transition of mitotic cell cycle|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|dynein complex|growth cone|spectrin binding|vesicle|melanosome transport|identical protein binding|extracellular exosome|protein localization to centrosome|ciliary basal body-plasma membrane docking "hsa04962,hsa05014,hsa05016,hsa05022,hsa05132" Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTN3 1347.857067 1280.874432 1414.839702 1.104588917 0.143509558 0.670646482 1 70.13164468 80.80358604 11258 dynactin subunit 3 "GO:0000086,GO:0000278,GO:0000777,GO:0005198,GO:0005515,GO:0005730,GO:0005813,GO:0005819,GO:0005829,GO:0005869,GO:0005874,GO:0006888,GO:0007017,GO:0010389,GO:0019886,GO:0030496,GO:0032154,GO:0048471,GO:0061640,GO:0097711" G2/M transition of mitotic cell cycle|mitotic cell cycle|condensed chromosome kinetochore|structural molecule activity|protein binding|nucleolus|centrosome|spindle|cytosol|dynactin complex|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based process|regulation of G2/M transition of mitotic cell cycle|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|cleavage furrow|perinuclear region of cytoplasm|cytoskeleton-dependent cytokinesis|ciliary basal body-plasma membrane docking "hsa05014,hsa05016,hsa05022,hsa05132" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTN4 1562.587802 1613.77999 1511.395615 0.936556175 -0.094562564 0.775738377 1 17.21404031 16.8163825 51164 dynactin subunit 4 "GO:0000776,GO:0000922,GO:0001725,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005868,GO:0005869,GO:0005925,GO:0005938,GO:0006888,GO:0019886,GO:0030017,GO:0047485" kinetochore|spindle pole|stress fiber|protein binding|nucleus|cytoplasm|centrosome|cytosol|cytoplasmic dynein complex|dynactin complex|focal adhesion|cell cortex|endoplasmic reticulum to Golgi vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|sarcomere|protein N-terminus binding "hsa04962,hsa05014,hsa05016,hsa05022,hsa05132" Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTN5 1549.069243 1902.027485 1196.111002 0.62886105 -0.669186813 0.043228109 0.94601832 8.46791334 5.554526348 84516 dynactin subunit 5 "GO:0000777,GO:0003281,GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0006888,GO:0019886,GO:0031965,GO:0035904,GO:0060976" condensed chromosome kinetochore|ventricular septum development|protein binding|nucleoplasm|centrosome|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|nuclear membrane|aorta development|coronary vasculature development "hsa04962,hsa05014,hsa05016,hsa05022,hsa05132" Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTN6 557.6458057 537.9266632 577.3649481 1.073315356 0.102074024 0.801044094 1 25.84828065 28.93842783 10671 dynactin subunit 6 "GO:0000777,GO:0005813,GO:0005829,GO:0005869,GO:0006888,GO:0007052,GO:0019886,GO:0070840" condensed chromosome kinetochore|centrosome|cytosol|dynactin complex|endoplasmic reticulum to Golgi vesicle-mediated transport|mitotic spindle organization|antigen processing and presentation of exogenous peptide antigen via MHC class II|dynein complex binding "hsa04962,hsa05014,hsa05016,hsa05022,hsa05132" Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTPP1 648.3507529 710.4691779 586.2323278 0.825134075 -0.277299535 0.471216466 1 30.46804189 26.22315826 79077 dCTP pyrophosphatase 1 "GO:0000287,GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0006253,GO:0009143,GO:0032556,GO:0042262,GO:0042802,GO:0046076,GO:0047429,GO:0047840" magnesium ion binding|protein binding|nucleus|mitochondrion|cytosol|dCTP catabolic process|nucleoside triphosphate catabolic process|pyrimidine deoxyribonucleotide binding|DNA protection|identical protein binding|dTTP catabolic process|nucleoside-triphosphate diphosphatase activity|dCTP diphosphatase activity hsa00240 Pyrimidine metabolism DCUN1D1 617.3149237 710.4691779 524.1606696 0.737766938 -0.438762958 0.258784197 1 4.159375503 3.200834712 54165 defective in cullin neddylation 1 domain containing 1 "GO:0000151,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0031396,GO:0031624,GO:0032182,GO:0043687,GO:0045116,GO:0051443,GO:0097602,GO:2000434,GO:2000436" ubiquitin ligase complex|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of protein ubiquitination|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|post-translational protein modification|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|regulation of protein neddylation|positive regulation of protein neddylation DCUN1D2 369.6965968 385.683268 353.7099255 0.917099483 -0.124849856 0.783026713 1 2.266329843 2.16798112 55208 defective in cullin neddylation 1 domain containing 2 "GO:0000151,GO:0005515,GO:0005634,GO:0005737,GO:0031624,GO:0032182,GO:0045116,GO:0051443,GO:0097602,GO:2000434,GO:2000436" ubiquitin ligase complex|protein binding|nucleus|cytoplasm|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|regulation of protein neddylation|positive regulation of protein neddylation DCUN1D3 147.2564523 131.9442759 162.5686287 1.232100655 0.30112012 0.618853107 1 1.089066509 1.399640566 123879 defective in cullin neddylation 1 domain containing 3 "GO:0000151,GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0010225,GO:0010332,GO:0010564,GO:0030308,GO:0031624,GO:0032182,GO:0043065,GO:0043687,GO:0045116,GO:0048471,GO:0051443,GO:0097602,GO:2000134,GO:2000434,GO:2000435,GO:2000436" ubiquitin ligase complex|molecular_function|protein binding|nucleus|cytoplasm|plasma membrane|response to UV-C|response to gamma radiation|regulation of cell cycle process|negative regulation of cell growth|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|positive regulation of apoptotic process|post-translational protein modification|protein neddylation|perinuclear region of cytoplasm|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|negative regulation of G1/S transition of mitotic cell cycle|regulation of protein neddylation|negative regulation of protein neddylation|positive regulation of protein neddylation DCUN1D4 692.1532037 673.930763 710.3756443 1.054078079 0.075981737 0.844253258 1 7.26062873 7.982941402 23142 defective in cullin neddylation 1 domain containing 4 "GO:0000151,GO:0005515,GO:0005634,GO:0031624,GO:0032182,GO:0045116,GO:0051443,GO:0097602,GO:2000436" ubiquitin ligase complex|protein binding|nucleus|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|positive regulation of protein neddylation DCUN1D5 849.5389267 892.1462962 806.9315572 0.904483447 -0.144833995 0.691785271 1 3.337819502 3.149048872 84259 defective in cullin neddylation 1 domain containing 5 "GO:0000151,GO:0001558,GO:0005515,GO:0005634,GO:0005819,GO:0006974,GO:0031624,GO:0032182,GO:0045116,GO:0051443,GO:0097602,GO:2000434,GO:2000436" ubiquitin ligase complex|regulation of cell growth|protein binding|nucleus|spindle|cellular response to DNA damage stimulus|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|regulation of protein neddylation|positive regulation of protein neddylation DCXR 327.4517147 360.3093688 294.5940605 0.817614212 -0.290507821 0.529973701 1 21.57021091 18.39580313 51181 dicarbonyl and L-xylulose reductase "GO:0004090,GO:0005515,GO:0005634,GO:0005881,GO:0005886,GO:0005902,GO:0005903,GO:0005997,GO:0006006,GO:0006739,GO:0016655,GO:0019640,GO:0042732,GO:0042802,GO:0044105,GO:0050038,GO:0055114,GO:0070062" "carbonyl reductase (NADPH) activity|protein binding|nucleus|cytoplasmic microtubule|plasma membrane|microvillus|brush border|xylulose metabolic process|glucose metabolic process|NADP metabolic process|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|glucuronate catabolic process to xylulose 5-phosphate|D-xylose metabolic process|identical protein binding|L-xylulose reductase (NAD+) activity|L-xylulose reductase (NADP+) activity|oxidation-reduction process|extracellular exosome" hsa00040 Pentose and glucuronate interconversions DDA1 839.7713978 763.2468882 916.2959074 1.200523607 0.263663773 0.469398233 1 11.23061078 14.06338967 79016 DET1 and DDB1 associated 1 "GO:0000209,GO:0005515,GO:0005654,GO:0032436,GO:0043687,GO:0080008" protein polyubiquitination|protein binding|nucleoplasm|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DDAH1 758.6961621 945.9389625 571.4533616 0.604112299 -0.727111336 0.050750393 1 9.025710509 5.687416155 23576 dimethylarginine dimethylaminohydrolase 1 "GO:0000052,GO:0003073,GO:0003824,GO:0005829,GO:0006525,GO:0006527,GO:0007263,GO:0008285,GO:0016403,GO:0016597,GO:0043116,GO:0045429,GO:0045766,GO:0046872,GO:0050999,GO:0070062,GO:1900038" citrulline metabolic process|regulation of systemic arterial blood pressure|catalytic activity|cytosol|arginine metabolic process|arginine catabolic process|nitric oxide mediated signal transduction|negative regulation of cell population proliferation|dimethylargininase activity|amino acid binding|negative regulation of vascular permeability|positive regulation of nitric oxide biosynthetic process|positive regulation of angiogenesis|metal ion binding|regulation of nitric-oxide synthase activity|extracellular exosome|negative regulation of cellular response to hypoxia DDAH2 754.0588368 696.2597943 811.8578792 1.16602723 0.22160148 0.552381849 1 19.05083864 23.17067687 23564 dimethylarginine dimethylaminohydrolase 2 "GO:0000052,GO:0003824,GO:0005515,GO:0005739,GO:0005829,GO:0006525,GO:0006527,GO:0006809,GO:0007263,GO:0016403,GO:0016597,GO:0043066,GO:0045429,GO:0050999,GO:0070062" citrulline metabolic process|catalytic activity|protein binding|mitochondrion|cytosol|arginine metabolic process|arginine catabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction|dimethylargininase activity|amino acid binding|negative regulation of apoptotic process|positive regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity|extracellular exosome DDB1 9428.755587 9381.238016 9476.273158 1.010130341 0.014541462 0.965686662 1 111.9261744 117.9301921 1642 damage specific DNA binding protein 1 "GO:0000715,GO:0000717,GO:0000781,GO:0003677,GO:0003684,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006511,GO:0006974,GO:0010498,GO:0016032,GO:0016567,GO:0030674,GO:0031461,GO:0031464,GO:0031465,GO:0032991,GO:0033683,GO:0035518,GO:0042769,GO:0043161,GO:0043687,GO:0044877,GO:0045070,GO:0045722,GO:0045732,GO:0046726,GO:0048511,GO:0051702,GO:0070062,GO:0070911,GO:0070914,GO:0071987,GO:0080008,GO:0097602,GO:1901990,GO:1902188" "nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|chromosome, telomeric region|DNA binding|damaged DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|proteasomal protein catabolic process|viral process|protein ubiquitination|protein-macromolecule adaptor activity|cullin-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|protein-containing complex|nucleotide-excision repair, DNA incision|histone H2A monoubiquitination|DNA damage response, detection of DNA damage|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|protein-containing complex binding|positive regulation of viral genome replication|positive regulation of gluconeogenesis|positive regulation of protein catabolic process|positive regulation by virus of viral protein levels in host cell|rhythmic process|biological process involved in interaction with symbiont|extracellular exosome|global genome nucleotide-excision repair|UV-damage excision repair|WD40-repeat domain binding|Cul4-RING E3 ubiquitin ligase complex|cullin family protein binding|regulation of mitotic cell cycle phase transition|positive regulation of viral release from host cell" "hsa03420,hsa04120,hsa05161,hsa05170,hsa05203" Nucleotide excision repair|Ubiquitin mediated proteolysis|Hepatitis B|Human immunodeficiency virus 1 infection|Viral carcinogenesis DDB2 510.4867257 547.061267 473.9121844 0.86628722 -0.20708266 0.612591765 1 15.26541226 13.79387782 1643 damage specific DNA binding protein 2 "GO:0000209,GO:0000715,GO:0000717,GO:0003677,GO:0003684,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006289,GO:0006290,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0009411,GO:0016579,GO:0030054,GO:0031465,GO:0032991,GO:0033683,GO:0035518,GO:0043687,GO:0044877,GO:0051865,GO:0070911,GO:0070914,GO:0080008" "protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|DNA binding|damaged DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|DNA repair|nucleotide-excision repair|pyrimidine dimer repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to UV|protein deubiquitination|cell junction|Cul4B-RING E3 ubiquitin ligase complex|protein-containing complex|nucleotide-excision repair, DNA incision|histone H2A monoubiquitination|post-translational protein modification|protein-containing complex binding|protein autoubiquitination|global genome nucleotide-excision repair|UV-damage excision repair|Cul4-RING E3 ubiquitin ligase complex" "hsa03420,hsa04115,hsa04120,hsa05161,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Nucleotide excision repair|p53 signaling pathway|Ubiquitin mediated proteolysis|Hepatitis B|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer DDHD1 771.8920735 770.35158 773.432567 1.003999456 0.005758487 0.991564295 1 2.98649647 3.127601501 80821 DDHD domain containing 1 "GO:0004620,GO:0005515,GO:0005737,GO:0005829,GO:0006654,GO:0016042,GO:0046872,GO:0090141" phospholipase activity|protein binding|cytoplasm|cytosol|phosphatidic acid biosynthetic process|lipid catabolic process|metal ion binding|positive regulation of mitochondrial fission DDHD2 969.0731256 846.4732776 1091.672974 1.289672105 0.367004311 0.300491244 1 7.405577014 9.962174363 23259 DDHD domain containing 2 "GO:0004620,GO:0004806,GO:0005737,GO:0005793,GO:0005794,GO:0005829,GO:0006654,GO:0007626,GO:0008542,GO:0016020,GO:0019433,GO:0030134,GO:0034389,GO:0034451,GO:0046872,GO:0090141" phospholipase activity|triglyceride lipase activity|cytoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|phosphatidic acid biosynthetic process|locomotory behavior|visual learning|membrane|triglyceride catabolic process|COPII-coated ER to Golgi transport vesicle|lipid droplet organization|centriolar satellite|metal ion binding|positive regulation of mitochondrial fission DDI2 717.2692815 774.4114039 660.1271591 0.852424378 -0.230356243 0.540990996 1 3.676873127 3.269267337 84301 DNA damage inducible 1 homolog 2 "GO:0004190,GO:0005515,GO:0005654,GO:0005694,GO:0005829,GO:0010498,GO:0016485,GO:0031647,GO:0042802,GO:0043130,GO:0072711,GO:0097752" aspartic-type endopeptidase activity|protein binding|nucleoplasm|chromosome|cytosol|proteasomal protein catabolic process|protein processing|regulation of protein stability|identical protein binding|ubiquitin binding|cellular response to hydroxyurea|regulation of DNA stability DDIAS 367.4709681 401.9225635 333.0193728 0.828566005 -0.271311465 0.543650561 1 5.587691447 4.829202946 220042 DNA damage induced apoptosis suppressor "GO:0003674,GO:0005575,GO:0005634,GO:0005737,GO:0006915,GO:0071850,GO:0097752,GO:1902230" molecular_function|cellular_component|nucleus|cytoplasm|apoptotic process|mitotic cell cycle arrest|regulation of DNA stability|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage DDIT3 276.9144787 239.5296085 314.2993489 1.312152392 0.391935283 0.420479996 1 13.36049522 18.2861704 1649 DNA damage inducible transcript 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001955,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005770,GO:0005829,GO:0006355,GO:0006357,GO:0006974,GO:0006983,GO:0006986,GO:0007050,GO:0007605,GO:0008134,GO:0008140,GO:0009948,GO:0010506,GO:0016055,GO:0030968,GO:0032088,GO:0032689,GO:0032700,GO:0032713,GO:0032757,GO:0032792,GO:0032993,GO:0034976,GO:0036488,GO:0036499,GO:0036500,GO:0042594,GO:0042803,GO:0043161,GO:0043433,GO:0043522,GO:0043525,GO:0043618,GO:0045454,GO:0045599,GO:0045662,GO:0045892,GO:0045893,GO:0045944,GO:0046982,GO:0051091,GO:0051209,GO:0051898,GO:0070059,GO:0072655,GO:0090090,GO:0120163,GO:0140416,GO:1902237,GO:1903026,GO:1990440,GO:1990442,GO:1990617,GO:1990622,GO:2000016,GO:2001244" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blood vessel maturation|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|late endosome|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|ER overload response|response to unfolded protein|cell cycle arrest|sensory perception of sound|transcription factor binding|cAMP response element binding protein binding|anterior/posterior axis specification|regulation of autophagy|Wnt signaling pathway|endoplasmic reticulum unfolded protein response|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-4 production|positive regulation of interleukin-8 production|negative regulation of CREB transcription factor activity|protein-DNA complex|response to endoplasmic reticulum stress|CHOP-C/EBP complex|PERK-mediated unfolded protein response|ATF6-mediated unfolded protein response|response to starvation|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA-binding transcription factor activity|leucine zipper domain binding|positive regulation of neuron apoptotic process|regulation of transcription from RNA polymerase II promoter in response to stress|cell redox homeostasis|negative regulation of fat cell differentiation|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of DNA-binding transcription factor activity|release of sequestered calcium ion into cytosol|negative regulation of protein kinase B signaling|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|establishment of protein localization to mitochondrion|negative regulation of canonical Wnt signaling pathway|negative regulation of cold-induced thermogenesis|transcription regulator inhibitor activity|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|intrinsic apoptotic signaling pathway in response to nitrosative stress|CHOP-ATF4 complex|CHOP-ATF3 complex|negative regulation of determination of dorsal identity|positive regulation of intrinsic apoptotic signaling pathway" "hsa04010,hsa04141,hsa04210,hsa04932,hsa05010,hsa05012,hsa05014,hsa05020,hsa05022,hsa05202" MAPK signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Transcriptional misregulation in cancer DDIT4 6013.83803 10190.15792 1837.518137 0.180322832 -2.471346015 5.30E-13 1.03E-09 295.9263475 55.66090758 54541 DNA damage inducible transcript 4 "GO:0001666,GO:0001764,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0007420,GO:0010801,GO:0030182,GO:0032006,GO:0032007,GO:0032984,GO:0033137,GO:0042771,GO:0045820,GO:0048011,GO:0051607,GO:0071549,GO:0071889,GO:0072593,GO:1901216,GO:1902532" response to hypoxia|neuron migration|protein binding|cytoplasm|mitochondrion|cytosol|apoptotic process|brain development|negative regulation of peptidyl-threonine phosphorylation|neuron differentiation|regulation of TOR signaling|negative regulation of TOR signaling|protein-containing complex disassembly|negative regulation of peptidyl-serine phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of glycolytic process|neurotrophin TRK receptor signaling pathway|defense response to virus|cellular response to dexamethasone stimulus|14-3-3 protein binding|reactive oxygen species metabolic process|positive regulation of neuron death|negative regulation of intracellular signal transduction "hsa04140,hsa04150,hsa04151,hsa05206" Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|MicroRNAs in cancer DDIT4L 22.03211579 24.35894324 19.70528833 0.808954975 -0.305868687 0.811270506 1 0.473769025 0.399767002 115265 DNA damage inducible transcript 4 like "GO:0005515,GO:0005737,GO:0009968" protein binding|cytoplasm|negative regulation of signal transduction DDN 39.55631282 43.64310664 35.469519 0.812717557 -0.299174035 0.762417238 1 0.483035268 0.40948162 23109 dendrin "GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0032591,GO:0042995,GO:0043204,GO:0045211" protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|dendritic spine membrane|cell projection|perikaryon|postsynaptic membrane DDO 5.970969603 4.059823873 7.882115332 1.941491941 0.957165719 0.632358107 1 0.065171397 0.13198013 8528 D-aspartate oxidase "GO:0003884,GO:0005515,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006533,GO:0006625,GO:0007320,GO:0007625,GO:0008445,GO:0019478,GO:0034641,GO:0042445,GO:0055114,GO:0071949" D-amino-acid oxidase activity|protein binding|cytoplasm|peroxisome|peroxisomal matrix|cytosol|aspartate catabolic process|protein targeting to peroxisome|insemination|grooming behavior|D-aspartate oxidase activity|D-amino acid catabolic process|cellular nitrogen compound metabolic process|hormone metabolic process|oxidation-reduction process|FAD binding "hsa00250,hsa04146" "Alanine, aspartate and glutamate metabolism|Peroxisome" DDOST 7003.698687 7271.144557 6736.252816 0.926436376 -0.110236193 0.736640995 1 189.7258221 183.3403147 1650 dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006486,GO:0006487,GO:0008047,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0031647,GO:0034097,GO:0035577,GO:0042110,GO:0043231,GO:0043312,GO:0050790" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|protein glycosylation|protein N-linked glycosylation|enzyme activator activity|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|regulation of protein stability|response to cytokine|azurophil granule membrane|T cell activation|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of catalytic activity "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum DDR1 1305.964524 1144.870332 1467.058716 1.281419105 0.357742405 0.289672891 1 12.024812 16.07257347 780 discoidin domain receptor tyrosine kinase 1 "GO:0001558,GO:0001952,GO:0004714,GO:0005515,GO:0005518,GO:0005524,GO:0005615,GO:0005886,GO:0005887,GO:0007155,GO:0007169,GO:0007275,GO:0007566,GO:0007595,GO:0008285,GO:0010715,GO:0014909,GO:0030198,GO:0033674,GO:0038062,GO:0038063,GO:0038083,GO:0043235,GO:0043583,GO:0044319,GO:0046777,GO:0046872,GO:0060444,GO:0060749,GO:0061302,GO:0061564,GO:0070062,GO:1990138" "regulation of cell growth|regulation of cell-matrix adhesion|transmembrane receptor protein tyrosine kinase activity|protein binding|collagen binding|ATP binding|extracellular space|plasma membrane|integral component of plasma membrane|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|embryo implantation|lactation|negative regulation of cell population proliferation|regulation of extracellular matrix disassembly|smooth muscle cell migration|extracellular matrix organization|positive regulation of kinase activity|protein tyrosine kinase collagen receptor activity|collagen-activated tyrosine kinase receptor signaling pathway|peptidyl-tyrosine autophosphorylation|receptor complex|ear development|wound healing, spreading of cells|protein autophosphorylation|metal ion binding|branching involved in mammary gland duct morphogenesis|mammary gland alveolus development|smooth muscle cell-matrix adhesion|axon development|extracellular exosome|neuron projection extension" DDR2 22.5841311 28.41876711 16.74949508 0.589381482 -0.762726362 0.489235248 1 0.116941038 0.071891801 4921 discoidin domain receptor tyrosine kinase 2 "GO:0001503,GO:0003416,GO:0004714,GO:0005515,GO:0005518,GO:0005524,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007165,GO:0007169,GO:0007275,GO:0010715,GO:0010763,GO:0015629,GO:0016324,GO:0018108,GO:0030198,GO:0030199,GO:0030500,GO:0031214,GO:0033674,GO:0034103,GO:0035988,GO:0038062,GO:0038063,GO:0043235,GO:0045669,GO:0045860,GO:0046777,GO:0048146,GO:0051091,GO:0090091" ossification|endochondral bone growth|transmembrane receptor protein tyrosine kinase activity|protein binding|collagen binding|ATP binding|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|regulation of extracellular matrix disassembly|positive regulation of fibroblast migration|actin cytoskeleton|apical plasma membrane|peptidyl-tyrosine phosphorylation|extracellular matrix organization|collagen fibril organization|regulation of bone mineralization|biomineral tissue development|positive regulation of kinase activity|regulation of tissue remodeling|chondrocyte proliferation|protein tyrosine kinase collagen receptor activity|collagen-activated tyrosine kinase receptor signaling pathway|receptor complex|positive regulation of osteoblast differentiation|positive regulation of protein kinase activity|protein autophosphorylation|positive regulation of fibroblast proliferation|positive regulation of DNA-binding transcription factor activity|positive regulation of extracellular matrix disassembly DDRGK1 2010.584713 1795.457108 2225.712317 1.239635471 0.309915941 0.336152344 1 69.78784998 90.23805857 65992 DDRGK domain containing 1 "GO:0001103,GO:0005515,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0008284,GO:0010628,GO:0010629,GO:0030335,GO:0031647,GO:0032435,GO:0032436,GO:0033146,GO:0034976,GO:0043066,GO:0044389,GO:0045944,GO:0051092,GO:0051216,GO:0061709,GO:0070972,GO:0071569,GO:1901800,GO:1902808,GO:1903721,GO:1903895,GO:1905050,GO:1905552,GO:1905636,GO:1990592" RNA polymerase II repressing transcription factor binding|protein binding|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|positive regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell migration|regulation of protein stability|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|negative regulation of apoptotic process|ubiquitin-like protein ligase binding|positive regulation of transcription by RNA polymerase II|positive regulation of NF-kappaB transcription factor activity|cartilage development|reticulophagy|protein localization to endoplasmic reticulum|protein ufmylation|positive regulation of proteasomal protein catabolic process|positive regulation of cell cycle G1/S phase transition|positive regulation of I-kappaB phosphorylation|negative regulation of IRE1-mediated unfolded protein response|positive regulation of metallopeptidase activity|positive regulation of protein localization to endoplasmic reticulum|positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding|protein K69-linked ufmylation DDT 512.4842244 582.5847258 442.383723 0.759346587 -0.397169573 0.328432848 1 32.24684276 25.54131039 1652 D-dopachrome tautomerase "GO:0004167,GO:0005126,GO:0005615,GO:0005737,GO:0010760,GO:0032760,GO:0033981,GO:0042438,GO:0050178,GO:0050729,GO:0070062,GO:0070374" dopachrome isomerase activity|cytokine receptor binding|extracellular space|cytoplasm|negative regulation of macrophage chemotaxis|positive regulation of tumor necrosis factor production|D-dopachrome decarboxylase activity|melanin biosynthetic process|phenylpyruvate tautomerase activity|positive regulation of inflammatory response|extracellular exosome|positive regulation of ERK1 and ERK2 cascade DDTL 68.67827461 81.19647747 56.16007174 0.691656504 -0.531872362 0.49319803 1 0.990441989 0.714554632 100037417 D-dopachrome tautomerase like "GO:0005737,GO:0016829,GO:0070062" cytoplasm|lyase activity|extracellular exosome DDX1 2176.651255 2472.432739 1880.869771 0.760736477 -0.394531312 0.218660263 1 50.41062641 40.00113044 1653 DEAD-box helicase 1 "GO:0000245,GO:0003677,GO:0003682,GO:0003712,GO:0003723,GO:0003724,GO:0004386,GO:0004518,GO:0004527,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006302,GO:0006355,GO:0006388,GO:0006446,GO:0007275,GO:0008143,GO:0010494,GO:0016020,GO:0016032,GO:0032508,GO:0033677,GO:0043123,GO:0045087,GO:0051607,GO:0071920,GO:0072669,GO:0090305,GO:1903608,GO:1990904" "spliceosomal complex assembly|DNA binding|chromatin binding|transcription coregulator activity|RNA binding|RNA helicase activity|helicase activity|nuclease activity|exonuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|double-strand break repair|regulation of transcription, DNA-templated|tRNA splicing, via endonucleolytic cleavage and ligation|regulation of translational initiation|multicellular organism development|poly(A) binding|cytoplasmic stress granule|membrane|viral process|DNA duplex unwinding|DNA/RNA helicase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|defense response to virus|cleavage body|tRNA-splicing ligase complex|nucleic acid phosphodiester bond hydrolysis|protein localization to cytoplasmic stress granule|ribonucleoprotein complex" DDX10 756.2438874 811.9647747 700.5230002 0.862750481 -0.212984721 0.567794987 1 12.78307473 11.5036714 1662 DEAD-box helicase 10 "GO:0003723,GO:0003724,GO:0005524,GO:0005634,GO:0006364,GO:0097065" RNA binding|RNA helicase activity|ATP binding|nucleus|rRNA processing|anterior head development DDX11 876.7754749 800.800259 952.7506908 1.18974823 0.250656308 0.488072313 1 5.636146202 6.994444803 1663 DEAD/H-box helicase 11 "GO:0000785,GO:0000922,GO:0001650,GO:0003677,GO:0003678,GO:0003682,GO:0003688,GO:0003690,GO:0003697,GO:0003727,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0006281,GO:0006974,GO:0007062,GO:0007275,GO:0008094,GO:0008186,GO:0016032,GO:0030496,GO:0030892,GO:0031297,GO:0031390,GO:0032079,GO:0032091,GO:0032508,GO:0034085,GO:0035563,GO:0036498,GO:0044806,GO:0045142,GO:0045876,GO:0046872,GO:0051539,GO:0051880,GO:0070062,GO:0072711,GO:0072719,GO:1901838,GO:1904976,GO:1990700,GO:2000781" "chromatin|spindle pole|fibrillar center|DNA binding|DNA helicase activity|chromatin binding|DNA replication origin binding|double-stranded DNA binding|single-stranded DNA binding|single-stranded RNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|DNA repair|cellular response to DNA damage stimulus|sister chromatid cohesion|multicellular organism development|DNA-dependent ATPase activity|RNA-dependent ATPase activity|viral process|midbody|mitotic cohesin complex|replication fork processing|Ctf18 RFC-like complex|positive regulation of endodeoxyribonuclease activity|negative regulation of protein binding|DNA duplex unwinding|establishment of sister chromatid cohesion|positive regulation of chromatin binding|IRE1-mediated unfolded protein response|G-quadruplex DNA unwinding|triplex DNA binding|positive regulation of sister chromatid cohesion|metal ion binding|4 iron, 4 sulfur cluster binding|G-quadruplex DNA binding|extracellular exosome|cellular response to hydroxyurea|cellular response to cisplatin|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|cellular response to bleomycin|nucleolar chromatin organization|positive regulation of double-strand break repair" DDX17 10857.04136 10536.25791 11177.82481 1.060891343 0.085276903 0.80147226 1 111.9413244 123.873177 10521 DEAD-box helicase 17 "GO:0000380,GO:0000381,GO:0001837,GO:0003713,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006357,GO:0006364,GO:0006396,GO:0008186,GO:0010586,GO:0016020,GO:0016607,GO:0030520,GO:0030521,GO:0031047,GO:0045445,GO:0045944,GO:0051607,GO:1990904,GO:2001014" "alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|epithelial to mesenchymal transition|transcription coactivator activity|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|rRNA processing|RNA processing|RNA-dependent ATPase activity|miRNA metabolic process|membrane|nuclear speck|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|gene silencing by RNA|myoblast differentiation|positive regulation of transcription by RNA polymerase II|defense response to virus|ribonucleoprotein complex|regulation of skeletal muscle cell differentiation" DDX18 1209.392282 1345.831614 1072.95295 0.7972416 -0.326911103 0.338786462 1 18.1619034 15.10313983 8886 DEAD-box helicase 18 "GO:0000463,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005694,GO:0005730,GO:0016020,GO:0071392" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|RNA helicase activity|protein binding|ATP binding|chromosome|nucleolus|membrane|cellular response to estradiol stimulus" DDX19A 826.6106211 873.8770888 779.3441535 0.891823534 -0.165169824 0.652536099 1 14.11313511 13.12859821 55308 DEAD-box helicase 19A "GO:0003674,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0008150,GO:0010494,GO:0016020,GO:0016973" molecular_function|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|biological_process|cytoplasmic stress granule|membrane|poly(A)+ mRNA export from nucleus "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway DDX19B 478.052672 485.1489529 470.9563911 0.970745971 -0.042834281 0.922592387 1 6.481425207 6.56284338 11269 DEAD-box helicase 19B "GO:0003723,GO:0003724,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0006406,GO:0010494,GO:0016020,GO:0016973,GO:0070062" RNA binding|RNA helicase activity|helicase activity|protein binding|ATP binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|mRNA export from nucleus|cytoplasmic stress granule|membrane|poly(A)+ mRNA export from nucleus|extracellular exosome "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway DDX20 560.0320162 566.3454304 553.7186021 0.977704723 -0.032529273 0.939450872 1 7.967610583 8.125530834 11218 DEAD-box helicase 20 "GO:0000122,GO:0000244,GO:0000387,GO:0003677,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006396,GO:0016020,GO:0032797,GO:0034719,GO:0043065,GO:0051170,GO:0070491,GO:0097504" negative regulation of transcription by RNA polymerase II|spliceosomal tri-snRNP complex assembly|spliceosomal snRNP assembly|DNA binding|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|RNA processing|membrane|SMN complex|SMN-Sm protein complex|positive regulation of apoptotic process|import into nucleus|repressing transcription factor binding|Gemini of coiled bodies hsa03013 RNA transport DDX21 5994.759963 6696.679479 5292.840446 0.790367892 -0.339403754 0.29558781 1 70.58547163 58.19163235 9188 DExD-box helicase 21 "GO:0001649,GO:0002735,GO:0003723,GO:0003724,GO:0003725,GO:0005515,GO:0005524,GO:0005654,GO:0005694,GO:0005730,GO:0005739,GO:0005829,GO:0006364,GO:0006366,GO:0016020,GO:0019843,GO:0030515,GO:0035198,GO:0042802,GO:0043123,GO:0043330,GO:0045087,GO:0045815,GO:0051607,GO:0062176,GO:0097322" "osteoblast differentiation|positive regulation of myeloid dendritic cell cytokine production|RNA binding|RNA helicase activity|double-stranded RNA binding|protein binding|ATP binding|nucleoplasm|chromosome|nucleolus|mitochondrion|cytosol|rRNA processing|transcription by RNA polymerase II|membrane|rRNA binding|snoRNA binding|miRNA binding|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|innate immune response|positive regulation of gene expression, epigenetic|defense response to virus|R-loop disassembly|7SK snRNA binding" DDX23 2843.317483 2650.050033 3036.584932 1.145859472 0.196430123 0.537434474 1 41.22103359 49.26813991 9416 DEAD-box helicase 23 "GO:0000354,GO:0000375,GO:0000398,GO:0000785,GO:0003723,GO:0003724,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005682,GO:0005730,GO:0008380,GO:0046540,GO:0062176,GO:0070062,GO:0071013" "cis assembly of pre-catalytic spliceosome|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|chromatin|RNA binding|RNA helicase activity|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|U5 snRNP|nucleolus|RNA splicing|U4/U6 x U5 tri-snRNP complex|R-loop disassembly|extracellular exosome|catalytic step 2 spliceosome" hsa03040 Spliceosome DDX24 3831.554522 3728.948228 3934.160815 1.055032297 0.077287164 0.808821977 1 33.88804464 37.29307504 57062 DEAD-box helicase 24 "GO:0003723,GO:0003724,GO:0005524,GO:0005730,GO:0016020,GO:0016070" RNA binding|RNA helicase activity|ATP binding|nucleolus|membrane|RNA metabolic process DDX27 2301.933737 2415.595205 2188.272269 0.905893614 -0.142586462 0.656291955 1 45.94118491 43.41055317 55661 DEAD-box helicase 27 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005694,GO:0005730,GO:0006364" RNA binding|RNA helicase activity|protein binding|ATP binding|chromosome|nucleolus|rRNA processing DDX28 217.8579968 243.5894324 192.1265612 0.788731101 -0.342394563 0.516346531 1 5.324534061 4.380528452 55794 DEAD-box helicase 28 "GO:0003723,GO:0003724,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005829,GO:0019843,GO:0035770,GO:0042645,GO:1902775" RNA binding|RNA helicase activity|ATP binding|nucleoplasm|nucleolus|mitochondrion|cytosol|rRNA binding|ribonucleoprotein granule|mitochondrial nucleoid|mitochondrial large ribosomal subunit assembly DDX31 465.5235827 537.9266632 393.1205022 0.730806872 -0.452437894 0.277190106 1 3.885906119 2.962175983 64794 DEAD-box helicase 31 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005730,GO:0005794,GO:0042254,GO:0043231" RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleolus|Golgi apparatus|ribosome biogenesis|intracellular membrane-bounded organelle DDX39A 1505.944501 1681.78204 1330.106962 0.790891406 -0.338448477 0.307197296 1 48.53351985 40.03820285 10212 DExD-box helicase 39A "GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006405,GO:0006406,GO:0016020,GO:0016607,GO:0016887,GO:0031124,GO:0042802" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|RNA export from nucleus|mRNA export from nucleus|membrane|nuclear speck|ATPase activity|mRNA 3'-end processing|identical protein binding" DDX39B 4497.120432 4403.893947 4590.346917 1.042338206 0.059823463 0.852128839 1 132.6839336 144.2590025 7919 DExD-box helicase 39B "GO:0000245,GO:0000346,GO:0000398,GO:0001889,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005681,GO:0005687,GO:0005688,GO:0005737,GO:0006405,GO:0006406,GO:0008186,GO:0008380,GO:0010501,GO:0016363,GO:0016607,GO:0016887,GO:0017070,GO:0030621,GO:0031124,GO:0032786,GO:0042802,GO:0043008,GO:0044877,GO:0045727,GO:0046784,GO:0061051,GO:1904707,GO:2000002,GO:2000573" "spliceosomal complex assembly|transcription export complex|mRNA splicing, via spliceosome|liver development|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|spliceosomal complex|U4 snRNP|U6 snRNP|cytoplasm|RNA export from nucleus|mRNA export from nucleus|RNA-dependent ATPase activity|RNA splicing|RNA secondary structure unwinding|nuclear matrix|nuclear speck|ATPase activity|U6 snRNA binding|U4 snRNA binding|mRNA 3'-end processing|positive regulation of DNA-templated transcription, elongation|identical protein binding|ATP-dependent protein binding|protein-containing complex binding|positive regulation of translation|viral mRNA export from host cell nucleus|positive regulation of cell growth involved in cardiac muscle cell development|positive regulation of vascular associated smooth muscle cell proliferation|negative regulation of DNA damage checkpoint|positive regulation of DNA biosynthetic process" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome DDX3X 9264.988164 9804.474654 8725.501673 0.889950964 -0.168202248 0.614953403 1 72.52257239 67.32172072 1654 DEAD-box helicase 3 X-linked "GO:0003677,GO:0003678,GO:0003723,GO:0003724,GO:0003729,GO:0003924,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005852,GO:0005886,GO:0006413,GO:0007059,GO:0007276,GO:0008134,GO:0008143,GO:0008190,GO:0008625,GO:0009615,GO:0010494,GO:0010501,GO:0010628,GO:0016032,GO:0016055,GO:0016887,GO:0017111,GO:0017148,GO:0022627,GO:0030027,GO:0030154,GO:0030307,GO:0030308,GO:0031252,GO:0031333,GO:0031369,GO:0031954,GO:0032508,GO:0032727,GO:0032728,GO:0033592,GO:0034063,GO:0034157,GO:0034161,GO:0034774,GO:0035556,GO:0035613,GO:0036493,GO:0042256,GO:0043015,GO:0043024,GO:0043065,GO:0043066,GO:0043154,GO:0043186,GO:0043273,GO:0043280,GO:0043312,GO:0043539,GO:0045070,GO:0045087,GO:0045296,GO:0045727,GO:0045944,GO:0045948,GO:0048027,GO:0055088,GO:0070062,GO:0071243,GO:0071470,GO:0071651,GO:0071902,GO:0072559,GO:0090263,GO:0097193,GO:0098586,GO:1900087,GO:1900227,GO:1901223,GO:1901224,GO:1901985,GO:1902042,GO:1902523,GO:1903608,GO:1904813,GO:2001243" DNA binding|DNA helicase activity|RNA binding|RNA helicase activity|mRNA binding|GTPase activity|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|eukaryotic translation initiation factor 3 complex|plasma membrane|translational initiation|chromosome segregation|gamete generation|transcription factor binding|poly(A) binding|eukaryotic initiation factor 4E binding|extrinsic apoptotic signaling pathway via death domain receptors|response to virus|cytoplasmic stress granule|RNA secondary structure unwinding|positive regulation of gene expression|viral process|Wnt signaling pathway|ATPase activity|nucleoside-triphosphatase activity|negative regulation of translation|cytosolic small ribosomal subunit|lamellipodium|cell differentiation|positive regulation of cell growth|negative regulation of cell growth|cell leading edge|negative regulation of protein-containing complex assembly|translation initiation factor binding|positive regulation of protein autophosphorylation|DNA duplex unwinding|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|RNA strand annealing activity|stress granule assembly|positive regulation of toll-like receptor 7 signaling pathway|positive regulation of toll-like receptor 8 signaling pathway|secretory granule lumen|intracellular signal transduction|RNA stem-loop binding|positive regulation of translation in response to endoplasmic reticulum stress|mature ribosome assembly|gamma-tubulin binding|ribosomal small subunit binding|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|P granule|CTPase activity|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|protein serine/threonine kinase activator activity|positive regulation of viral genome replication|innate immune response|cadherin binding|positive regulation of translation|positive regulation of transcription by RNA polymerase II|positive regulation of translational initiation|mRNA 5'-UTR binding|lipid homeostasis|extracellular exosome|cellular response to arsenic-containing substance|cellular response to osmotic stress|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of protein serine/threonine kinase activity|NLRP3 inflammasome complex|positive regulation of canonical Wnt signaling pathway|intrinsic apoptotic signaling pathway|cellular response to virus|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of NLRP3 inflammasome complex assembly|negative regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling|positive regulation of protein acetylation|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of protein K63-linked ubiquitination|protein localization to cytoplasmic stress granule|ficolin-1-rich granule lumen|negative regulation of intrinsic apoptotic signaling pathway "hsa04622,hsa05161,hsa05203" RIG-I-like receptor signaling pathway|Hepatitis B|Viral carcinogenesis DDX41 1637.039846 1921.311648 1352.768044 0.704085693 -0.506177067 0.123283111 1 42.56677909 31.26167466 51428 DEAD-box helicase 41 "GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005681,GO:0005829,GO:0006915,GO:0008283,GO:0016020,GO:0030154,GO:0032481,GO:0046872,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|spliceosomal complex|cytosol|apoptotic process|cell population proliferation|membrane|cell differentiation|positive regulation of type I interferon production|metal ion binding|catalytic step 2 spliceosome" DDX42 3488.939088 3510.732695 3467.145482 0.987584582 -0.018023781 0.955764113 1 35.94223284 37.02501851 11325 DEAD-box helicase 42 "GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008104,GO:0015030,GO:0016020,GO:0016607,GO:0042981" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein localization|Cajal body|membrane|nuclear speck|regulation of apoptotic process" hsa03040 Spliceosome DDX46 2163.597613 1815.756227 2511.438998 1.383136657 0.467943705 0.144873213 1 15.14769351 21.85382849 9879 DEAD-box helicase 46 "GO:0000398,GO:0001650,GO:0003723,GO:0003724,GO:0005524,GO:0005634,GO:0005654,GO:0015030,GO:0016020,GO:0016607" "mRNA splicing, via spliceosome|fibrillar center|RNA binding|RNA helicase activity|ATP binding|nucleus|nucleoplasm|Cajal body|membrane|nuclear speck" hsa03040 Spliceosome DDX47 1119.924977 1190.543351 1049.306604 0.881367825 -0.182183864 0.599286875 1 33.18482154 30.50792066 51202 DEAD-box helicase 47 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0006397,GO:0008380,GO:0008625,GO:0016020" RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|rRNA processing|mRNA processing|RNA splicing|extrinsic apoptotic signaling pathway via death domain receptors|membrane DDX49 495.3905549 592.7342855 398.0468243 0.671543445 -0.574447357 0.160968501 1 15.95954307 11.17919412 54555 DEAD-box helicase 49 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006364,GO:0030307,GO:0044357" RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|rRNA processing|positive regulation of cell growth|regulation of rRNA stability DDX5 11953.006 10998.06287 12907.94912 1.173656604 0.231010357 0.499464925 1 135.4274461 165.792036 1655 DEAD-box helicase 5 "GO:0000122,GO:0000380,GO:0000381,GO:0000398,GO:0000956,GO:0001837,GO:0003723,GO:0003724,GO:0003730,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006357,GO:0009299,GO:0016020,GO:0030509,GO:0030520,GO:0030521,GO:0035500,GO:0036002,GO:0043021,GO:0043517,GO:0045445,GO:0045667,GO:0046332,GO:0048511,GO:0050681,GO:0060765,GO:0061614,GO:0070062,GO:0070412,GO:0070878,GO:0071013,GO:0072332,GO:1902893,GO:1903800,GO:1990841,GO:1990904,GO:2001014" "negative regulation of transcription by RNA polymerase II|alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process|epithelial to mesenchymal transition|RNA binding|RNA helicase activity|mRNA 3'-UTR binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|regulation of transcription by RNA polymerase II|mRNA transcription|membrane|BMP signaling pathway|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|MH2 domain binding|pre-mRNA binding|ribonucleoprotein complex binding|positive regulation of DNA damage response, signal transduction by p53 class mediator|myoblast differentiation|regulation of osteoblast differentiation|SMAD binding|rhythmic process|androgen receptor binding|regulation of androgen receptor signaling pathway|pri-miRNA transcription by RNA polymerase II|extracellular exosome|R-SMAD binding|primary miRNA binding|catalytic step 2 spliceosome|intrinsic apoptotic signaling pathway by p53 class mediator|regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of production of miRNAs involved in gene silencing by miRNA|promoter-specific chromatin binding|ribonucleoprotein complex|regulation of skeletal muscle cell differentiation" "hsa03040,hsa05202,hsa05205" Spliceosome|Transcriptional misregulation in cancer|Proteoglycans in cancer other DDX50 1234.797356 1196.633087 1272.961626 1.063786085 0.08920807 0.795151333 1 9.656667364 10.71513153 79009 DExD-box helicase 50 "GO:0003723,GO:0003724,GO:0005524,GO:0005730,GO:0005886,GO:0016020" RNA binding|RNA helicase activity|ATP binding|nucleolus|plasma membrane|membrane DDX51 881.8717815 913.4603715 850.2831915 0.930837525 -0.103398723 0.776525019 1 9.772612024 9.488563536 317781 DEAD-box helicase 51 "GO:0003723,GO:0003724,GO:0005524,GO:0005634,GO:0005730,GO:0006364,GO:0016020" RNA binding|RNA helicase activity|ATP binding|nucleus|nucleolus|rRNA processing|membrane DDX52 1275.367141 1444.282343 1106.45194 0.766091163 -0.384412015 0.256821823 1 10.9519098 8.751575437 11056 DExD-box helicase 52 "GO:0003723,GO:0003724,GO:0005524,GO:0005654,GO:0005730,GO:0006364,GO:0016020,GO:0030490" RNA binding|RNA helicase activity|ATP binding|nucleoplasm|nucleolus|rRNA processing|membrane|maturation of SSU-rRNA DDX54 2384.218161 2416.610161 2351.826162 0.973192201 -0.039203335 0.903564334 1 27.94355693 28.36587837 79039 DEAD-box helicase 54 "GO:0003714,GO:0003723,GO:0003724,GO:0005102,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005794,GO:0006364,GO:0006396,GO:0016020,GO:0016070,GO:0030331,GO:0030520,GO:0045892" "transcription corepressor activity|RNA binding|RNA helicase activity|signaling receptor binding|ATP binding|nucleus|nucleoplasm|nucleolus|Golgi apparatus|rRNA processing|RNA processing|membrane|RNA metabolic process|estrogen receptor binding|intracellular estrogen receptor signaling pathway|negative regulation of transcription, DNA-templated" DDX55 556.7441727 611.003493 502.4848524 0.822392766 -0.282100521 0.479448753 1 8.503756919 7.294676694 57696 DEAD-box helicase 55 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005829,GO:0016020" RNA binding|RNA helicase activity|protein binding|ATP binding|nucleoplasm|nucleolus|cytosol|membrane DDX56 1608.738607 1704.111071 1513.366144 0.888067785 -0.171258295 0.603152615 1 46.5268 43.0988051 54606 DEAD-box helicase 56 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005730,GO:0006364,GO:0010976,GO:0016020" RNA binding|RNA helicase activity|protein binding|ATP binding|nucleolus|rRNA processing|positive regulation of neuron projection development|membrane DDX58 1266.808801 1499.089965 1034.527637 0.690103771 -0.535114779 0.115054864 1 16.35932305 11.77594202 23586 DExD/H-box helicase 58 "GO:0002230,GO:0002735,GO:0003724,GO:0003725,GO:0003727,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005923,GO:0008270,GO:0009597,GO:0009615,GO:0010628,GO:0015629,GO:0016032,GO:0016579,GO:0030334,GO:0031625,GO:0032480,GO:0032587,GO:0032725,GO:0032727,GO:0032728,GO:0032755,GO:0032757,GO:0032760,GO:0034344,GO:0039528,GO:0039529,GO:0042802,GO:0043330,GO:0045087,GO:0045944,GO:0051091,GO:0051607,GO:0060760,GO:0071360,GO:0140374,GO:1990904" positive regulation of defense response to virus by host|positive regulation of myeloid dendritic cell cytokine production|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|bicellular tight junction|zinc ion binding|detection of virus|response to virus|positive regulation of gene expression|actin cytoskeleton|viral process|protein deubiquitination|regulation of cell migration|ubiquitin protein ligase binding|negative regulation of type I interferon production|ruffle membrane|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|regulation of type III interferon production|cytoplasmic pattern recognition receptor signaling pathway in response to virus|RIG-I signaling pathway|identical protein binding|response to exogenous dsRNA|innate immune response|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|defense response to virus|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA|antiviral innate immune response|ribonucleoprotein complex "hsa04064,hsa04622,hsa04623,hsa05160,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05171" NF-kappa B signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 DDX59 363.5056621 332.9055576 394.1057666 1.183836549 0.243469904 0.587614434 1 5.029979736 6.211177053 83479 DEAD-box helicase 59 "GO:0003723,GO:0003724,GO:0005524,GO:0005634,GO:0005737,GO:0046872" RNA binding|RNA helicase activity|ATP binding|nucleus|cytoplasm|metal ion binding DDX6 3240.381272 3357.474343 3123.2882 0.930249313 -0.104310675 0.743487136 1 26.82085663 26.02483185 1656 DEAD-box helicase 6 "GO:0000792,GO:0000932,GO:0001520,GO:0003723,GO:0003724,GO:0003729,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005912,GO:0010494,GO:0016020,GO:0016442,GO:0017148,GO:0019074,GO:0019827,GO:0019904,GO:0033391,GO:0033962,GO:0034063,GO:0036464,GO:0043928,GO:0045296,GO:0045665,GO:0048471,GO:0048515,GO:0061830,GO:0097227,GO:1905618" heterochromatin|P-body|outer dense fiber|RNA binding|RNA helicase activity|mRNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|adherens junction|cytoplasmic stress granule|membrane|RISC complex|negative regulation of translation|viral RNA genome packaging|stem cell population maintenance|protein domain specific binding|chromatoid body|P-body assembly|stress granule assembly|cytoplasmic ribonucleoprotein granule|exonucleolytic catabolism of deadenylated mRNA|cadherin binding|negative regulation of neuron differentiation|perinuclear region of cytoplasm|spermatid differentiation|concave side of sperm head|sperm annulus|positive regulation of miRNA mediated inhibition of translation hsa03018 RNA degradation DDX60 560.0805129 704.3794421 415.7815838 0.590280691 -0.760526945 0.056195742 1 3.528967637 2.172812156 55601 DExD/H-box helicase 60 "GO:0003690,GO:0003724,GO:0003725,GO:0003727,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0009615,GO:0045087,GO:0045111,GO:0051607,GO:1900245,GO:1900246" double-stranded DNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|protein binding|ATP binding|cytoplasm|cytosol|response to virus|innate immune response|intermediate filament cytoskeleton|defense response to virus|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway DDX60L 323.0355922 327.8307778 318.2404065 0.970745971 -0.042834281 0.93308034 1 1.946023485 1.970468985 91351 DExD/H-box 60 like "GO:0003723,GO:0003724,GO:0005524" RNA binding|RNA helicase activity|ATP binding DEAF1 890.2438074 946.9539185 833.5336964 0.88022625 -0.184053699 0.610318515 1 13.03966159 11.97227175 10522 DEAF1 transcription factor "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0001650,GO:0001843,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006366,GO:0007281,GO:0009653,GO:0033599,GO:0045892,GO:0045893,GO:0046872,GO:0048706" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|fibrillar center|neural tube closure|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|germ cell development|anatomical structure morphogenesis|regulation of mammary gland epithelial cell proliferation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|embryonic skeletal system development" DECR1 886.1273221 901.2808999 870.9737442 0.966373241 -0.049347588 0.894006517 1 25.03932971 25.23966139 1666 "2,4-dienoyl-CoA reductase 1" "GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006635,GO:0008670,GO:0042802,GO:0070402,GO:0120162,GO:1902494" "nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|fatty acid beta-oxidation|2,4-dienoyl-CoA reductase (NADPH) activity|identical protein binding|NADPH binding|positive regulation of cold-induced thermogenesis|catalytic complex" DECR2 314.1385209 325.8008658 302.4761759 0.92840814 -0.107168923 0.823867339 1 10.6387263 10.30254465 26063 "2,4-dienoyl-CoA reductase 2" "GO:0005515,GO:0005778,GO:0005829,GO:0006625,GO:0006636,GO:0008670,GO:0019166,GO:0033540" "protein binding|peroxisomal membrane|cytosol|protein targeting to peroxisome|unsaturated fatty acid biosynthetic process|2,4-dienoyl-CoA reductase (NADPH) activity|trans-2-enoyl-CoA reductase (NADPH) activity|fatty acid beta-oxidation using acyl-CoA oxidase" hsa04146 Peroxisome DEDD 976.4638465 1014.955968 937.9717246 0.924150164 -0.113800803 0.749689968 1 13.41789069 12.93429388 9191 death effector domain containing "GO:0003677,GO:0005515,GO:0005730,GO:0005737,GO:0007283,GO:0008625,GO:0042981" DNA binding|protein binding|nucleolus|cytoplasm|spermatogenesis|extrinsic apoptotic signaling pathway via death domain receptors|regulation of apoptotic process DEDD2 427.9877793 430.3413306 425.6342279 0.989061932 -0.015867234 0.976355425 1 9.555138203 9.857717984 162989 death effector domain containing 2 "GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0006396,GO:0008625,GO:0016075,GO:0019725,GO:0030159,GO:0030262,GO:0035556,GO:0045892,GO:2001238" "DNA binding|protein binding|nucleoplasm|nucleolus|RNA processing|extrinsic apoptotic signaling pathway via death domain receptors|rRNA catabolic process|cellular homeostasis|signaling receptor complex adaptor activity|apoptotic nuclear changes|intracellular signal transduction|negative regulation of transcription, DNA-templated|positive regulation of extrinsic apoptotic signaling pathway" DEF6 212.5956651 153.2583512 271.932979 1.774343628 0.827285436 0.118259076 1 3.380659768 6.256841108 50619 DEF6 guanine nucleotide exchange factor "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0016020,GO:0030175,GO:0048471" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|membrane|filopodium|perinuclear region of cytoplasm DEF8 854.1683332 871.8471768 836.4894896 0.959445086 -0.059727859 0.87213831 1 9.887143711 9.894797243 54849 differentially expressed in FDCP 8 homolog "GO:0032418,GO:0035556,GO:0045780,GO:0046872,GO:1900029" lysosome localization|intracellular signal transduction|positive regulation of bone resorption|metal ion binding|positive regulation of ruffle assembly DEGS1 2736.298765 2810.413076 2662.184454 0.947257354 -0.07817166 0.806943265 1 59.38152181 58.67258712 8560 "delta 4-desaturase, sphingolipid 1" "GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0006636,GO:0009055,GO:0016020,GO:0022900,GO:0030148,GO:0031966,GO:0035579,GO:0042284,GO:0043217,GO:0043312,GO:0046513,GO:0050251" protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|unsaturated fatty acid biosynthetic process|electron transfer activity|membrane|electron transport chain|sphingolipid biosynthetic process|mitochondrial membrane|specific granule membrane|sphingolipid delta-4 desaturase activity|myelin maintenance|neutrophil degranulation|ceramide biosynthetic process|retinol isomerase activity "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway DEGS2 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.025580462 0.038852697 123099 "delta 4-desaturase, sphingolipid 2" "GO:0000170,GO:0005789,GO:0006667,GO:0016021,GO:0030148,GO:0042284,GO:0046513,GO:0055114" sphingosine hydroxylase activity|endoplasmic reticulum membrane|sphinganine metabolic process|integral component of membrane|sphingolipid biosynthetic process|sphingolipid delta-4 desaturase activity|ceramide biosynthetic process|oxidation-reduction process "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway DEK 2934.682571 2598.287279 3271.077863 1.258936181 0.33220515 0.296653144 1 35.25156295 46.29115551 7913 DEK proto-oncogene "GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006357,GO:0006366,GO:0007165,GO:0019079,GO:0042393,GO:0045815,GO:2000779" "DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|signal transduction|viral genome replication|histone binding|positive regulation of gene expression, epigenetic|regulation of double-strand break repair" DELE1 1566.075568 1313.353023 1818.798113 1.384850898 0.469730654 0.154653824 1 10.76496155 15.55003709 9812 DAP3 binding cell death enhancer 1 "GO:0005515,GO:0005739,GO:0005743,GO:0005829,GO:0008625,GO:0043281" protein binding|mitochondrion|mitochondrial inner membrane|cytosol|extrinsic apoptotic signaling pathway via death domain receptors|regulation of cysteine-type endopeptidase activity involved in apoptotic process DENND10 505.7615635 459.7750537 551.7480733 1.200039169 0.263081496 0.519958086 1 7.950148337 9.951454994 404636 DENN domain containing 10 "GO:0005085,GO:0005770,GO:0015031,GO:0031267,GO:0032509,GO:0050790,GO:2000641" guanyl-nucleotide exchange factor activity|late endosome|protein transport|small GTPase binding|endosome transport via multivesicular body sorting pathway|regulation of catalytic activity|regulation of early endosome to late endosome transport DENND11 1219.972615 1025.105528 1414.839702 1.38018932 0.464866175 0.173264641 1 6.928864092 9.975085691 57189 DENN domain containing 11 "GO:0005085,GO:0005737,GO:0050790" guanyl-nucleotide exchange factor activity|cytoplasm|regulation of catalytic activity DENND1A 750.5186151 723.6636055 777.3736247 1.074219594 0.103288942 0.784059989 1 3.409079033 3.81984789 57706 DENN domain containing 1A "GO:0005085,GO:0005654,GO:0005829,GO:0006897,GO:0015031,GO:0017124,GO:0030136,GO:0030425,GO:0030665,GO:0031267,GO:0032266,GO:0032456,GO:0032483,GO:0042734,GO:0043025,GO:0043231,GO:0043547,GO:0048488,GO:1901981" guanyl-nucleotide exchange factor activity|nucleoplasm|cytosol|endocytosis|protein transport|SH3 domain binding|clathrin-coated vesicle|dendrite|clathrin-coated vesicle membrane|small GTPase binding|phosphatidylinositol-3-phosphate binding|endocytic recycling|regulation of Rab protein signal transduction|presynaptic membrane|neuronal cell body|intracellular membrane-bounded organelle|positive regulation of GTPase activity|synaptic vesicle endocytosis|phosphatidylinositol phosphate binding DENND1B 303.6150952 313.6213942 293.6087961 0.936188671 -0.095128789 0.846110245 1 0.652661266 0.637334091 163486 DENN domain containing 1B "GO:0005085,GO:0005829,GO:0006897,GO:0015031,GO:0016607,GO:0030136,GO:0031267,GO:0032456,GO:0035745,GO:0043231,GO:0043547,GO:0050776,GO:0050852,GO:1901981" guanyl-nucleotide exchange factor activity|cytosol|endocytosis|protein transport|nuclear speck|clathrin-coated vesicle|small GTPase binding|endocytic recycling|T-helper 2 cell cytokine production|intracellular membrane-bounded organelle|positive regulation of GTPase activity|regulation of immune response|T cell receptor signaling pathway|phosphatidylinositol phosphate binding DENND1C 6.956234019 4.059823873 9.852644165 2.426864926 1.279093814 0.45903564 1 0.062898671 0.159221975 79958 DENN domain containing 1C "GO:0005085,GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0006897,GO:0030136,GO:0032456,GO:0043231,GO:0050790,GO:1901981" guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|centrosome|cytosol|endocytosis|clathrin-coated vesicle|endocytic recycling|intracellular membrane-bounded organelle|regulation of catalytic activity|phosphatidylinositol phosphate binding DENND2A 1406.870496 1071.793503 1741.947488 1.625264087 0.700674159 0.036603591 0.862826216 10.47723603 17.76178449 27147 DENN domain containing 2A "GO:0005085,GO:0005829,GO:0015031,GO:0015629,GO:0042147,GO:0050790" "guanyl-nucleotide exchange factor activity|cytosol|protein transport|actin cytoskeleton|retrograde transport, endosome to Golgi|regulation of catalytic activity" DENND2B 808.8367675 803.845127 813.8284081 1.012419409 0.01780707 0.964928403 1 6.496237416 6.860223747 6764 DENN domain containing 2B "GO:0005085,GO:0005515,GO:0005886,GO:0005938,GO:0050790,GO:0055037,GO:0070374" guanyl-nucleotide exchange factor activity|protein binding|plasma membrane|cell cortex|regulation of catalytic activity|recycling endosome|positive regulation of ERK1 and ERK2 cascade DENND2C 125.0461872 95.40586103 154.6865134 1.621352312 0.697197616 0.268968454 1 0.782251949 1.322939486 163259 DENN domain containing 2C "GO:0005085,GO:0005654,GO:0050790" guanyl-nucleotide exchange factor activity|nucleoplasm|regulation of catalytic activity DENND2D 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.021986287 0.033393711 79961 DENN domain containing 2D "GO:0005085,GO:0005515,GO:0005654,GO:0005829,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|cytosol|regulation of catalytic activity DENND3 1037.754122 894.1762081 1181.332035 1.321140089 0.401783453 0.251356041 1 5.21017838 7.179883431 22898 DENN domain containing 3 "GO:0005085,GO:0005829,GO:0008333,GO:0031410,GO:0032483,GO:0044257,GO:0050790" guanyl-nucleotide exchange factor activity|cytosol|endosome to lysosome transport|cytoplasmic vesicle|regulation of Rab protein signal transduction|cellular protein catabolic process|regulation of catalytic activity DENND4A 677.4187747 676.9756309 677.8619186 1.001309187 0.001887522 1 1 2.514405066 2.626149064 10260 DENN domain containing 4A "GO:0003677,GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0006355,GO:0031410,GO:0032483,GO:0050790" "DNA binding|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|regulation of transcription, DNA-templated|cytoplasmic vesicle|regulation of Rab protein signal transduction|regulation of catalytic activity" DENND4B 1542.761026 1639.153889 1446.368163 0.882387049 -0.180516478 0.585485689 1 14.18130541 13.05242677 9909 DENN domain containing 4B "GO:0005085,GO:0005654,GO:0005794,GO:0005829,GO:0031410,GO:0032483,GO:0050790" guanyl-nucleotide exchange factor activity|nucleoplasm|Golgi apparatus|cytosol|cytoplasmic vesicle|regulation of Rab protein signal transduction|regulation of catalytic activity DENND4C 801.1328015 816.0245986 786.2410044 0.963501598 -0.053641036 0.887081625 1 5.492924928 5.520418878 55667 DENN domain containing 4C "GO:0005085,GO:0005794,GO:0005829,GO:0005886,GO:0015031,GO:0030659,GO:0030904,GO:0031410,GO:0032483,GO:0032593,GO:0032869,GO:0043231,GO:0050790,GO:0072659" guanyl-nucleotide exchange factor activity|Golgi apparatus|cytosol|plasma membrane|protein transport|cytoplasmic vesicle membrane|retromer complex|cytoplasmic vesicle|regulation of Rab protein signal transduction|insulin-responsive compartment|cellular response to insulin stimulus|intracellular membrane-bounded organelle|regulation of catalytic activity|protein localization to plasma membrane DENND5A 4890.752125 4910.356975 4871.147275 0.992014898 -0.011566307 0.971925522 1 49.47130656 51.19027996 23258 DENN domain containing 5A "GO:0000139,GO:0005085,GO:0005515,GO:0005802,GO:0005829,GO:0010977,GO:0030904,GO:0042147,GO:0050790" "Golgi membrane|guanyl-nucleotide exchange factor activity|protein binding|trans-Golgi network|cytosol|negative regulation of neuron projection development|retromer complex|retrograde transport, endosome to Golgi|regulation of catalytic activity" DENND5B 1103.411777 1038.299956 1168.523598 1.12542006 0.170463584 0.62401125 1 4.317424454 5.068218486 160518 DENN domain containing 5B "GO:0005085,GO:0005829,GO:0016021,GO:0050790" guanyl-nucleotide exchange factor activity|cytosol|integral component of membrane|regulation of catalytic activity DENND6A 558.6041001 502.4032043 614.8049959 1.223728254 0.291283223 0.46484096 1 5.208792206 6.648718557 201627 DENN domain containing 6A "GO:0005085,GO:0005737,GO:0005829,GO:0043231,GO:0050790,GO:0055037,GO:2000049" guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|intracellular membrane-bounded organelle|regulation of catalytic activity|recycling endosome|positive regulation of cell-cell adhesion mediated by cadherin DENND6B 339.0170663 410.0422112 267.9919213 0.653571545 -0.613582923 0.17804441 1 4.283661604 2.920278162 414918 DENN domain containing 6B "GO:0005085,GO:0005829,GO:0050790,GO:0055037" guanyl-nucleotide exchange factor activity|cytosol|regulation of catalytic activity|recycling endosome DENR 2300.758199 2368.90723 2232.609168 0.94246374 -0.085490981 0.790179847 1 44.12533807 43.37791025 8562 density regulated re-initiation and release factor "GO:0001731,GO:0002188,GO:0003674,GO:0003729,GO:0003743,GO:0005515,GO:0005575,GO:0032790,GO:0075522" formation of translation preinitiation complex|translation reinitiation|molecular_function|mRNA binding|translation initiation factor activity|protein binding|cellular_component|ribosome disassembly|IRES-dependent viral translational initiation DEPDC1 1468.817698 1501.119877 1436.515519 0.956962559 -0.063465614 0.850329481 1 14.34731575 14.32126999 55635 DEP domain containing 1 "GO:0005096,GO:0005515,GO:0005634,GO:0017053,GO:0035556,GO:0043547,GO:0045892" "GTPase activator activity|protein binding|nucleus|transcription repressor complex|intracellular signal transduction|positive regulation of GTPase activity|negative regulation of transcription, DNA-templated" DEPDC1B 753.3583637 682.0504107 824.6663166 1.209098776 0.273932109 0.462115391 1 6.028524812 7.60306606 55789 DEP domain containing 1B "GO:0005096,GO:0005829,GO:0016477,GO:0030177,GO:0035556,GO:0043547,GO:0051056" GTPase activator activity|cytosol|cell migration|positive regulation of Wnt signaling pathway|intracellular signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction DEPDC4 26.98812942 26.38885518 27.58740366 1.045418737 0.064080923 0.991192066 1 0.166335087 0.181380284 120863 DEP domain containing 4 GO:0035556 intracellular signal transduction DEPDC5 386.1640221 366.3991046 405.9289396 1.107887368 0.147811219 0.73983635 1 2.90449555 3.356466027 9681 "DEP domain containing 5, GATOR1 subcomplex subunit" "GO:0005096,GO:0005764,GO:0005765,GO:0005829,GO:0010506,GO:0031463,GO:0032007,GO:0034198,GO:0035556,GO:0043547,GO:0044877,GO:0048471,GO:1904262,GO:1990130" GTPase activator activity|lysosome|lysosomal membrane|cytosol|regulation of autophagy|Cul3-RING ubiquitin ligase complex|negative regulation of TOR signaling|cellular response to amino acid starvation|intracellular signal transduction|positive regulation of GTPase activity|protein-containing complex binding|perinuclear region of cytoplasm|negative regulation of TORC1 signaling|GATOR1 complex hsa04150 mTOR signaling pathway DEPDC7 42.63087227 51.76275439 33.49899016 0.64716398 -0.627796782 0.487952554 1 1.186244752 0.800764057 91614 DEP domain containing 7 "GO:0003674,GO:0005575,GO:0005829,GO:0008150,GO:0035556,GO:0051056" molecular_function|cellular_component|cytosol|biological_process|intracellular signal transduction|regulation of small GTPase mediated signal transduction DEPP1 202.6997214 318.6961741 86.70326866 0.272056196 -1.878023412 0.000684068 0.072436431 7.613602323 2.160552078 11067 DEPP1 autophagy regulator "GO:0005737,GO:0005739,GO:0005777,GO:0006914,GO:0010506,GO:0043231" cytoplasm|mitochondrion|peroxisome|autophagy|regulation of autophagy|intracellular membrane-bounded organelle DEPTOR 60.0335815 96.420817 23.646346 0.245241087 -2.027727389 0.014219074 0.528014603 1.900885258 0.486256103 64798 DEP domain containing MTOR interacting protein "GO:0005515,GO:0006469,GO:0032007,GO:0035556,GO:0045792,GO:2001236" protein binding|negative regulation of protein kinase activity|negative regulation of TOR signaling|intracellular signal transduction|negative regulation of cell size|regulation of extrinsic apoptotic signaling pathway "hsa04140,hsa04150" Autophagy - animal|mTOR signaling pathway DERA 490.4305819 455.7152298 525.145934 1.152355462 0.204585807 0.620631121 1 12.57100693 15.11027819 51071 deoxyribose-phosphate aldolase "GO:0004139,GO:0005515,GO:0005576,GO:0005654,GO:0005829,GO:0006098,GO:0009264,GO:0016052,GO:0034774,GO:0043312,GO:0046121,GO:0046386,GO:1904813" deoxyribose-phosphate aldolase activity|protein binding|extracellular region|nucleoplasm|cytosol|pentose-phosphate shunt|deoxyribonucleotide catabolic process|carbohydrate catabolic process|secretory granule lumen|neutrophil degranulation|deoxyribonucleoside catabolic process|deoxyribose phosphate catabolic process|ficolin-1-rich granule lumen hsa00030 Pentose phosphate pathway DERL1 3246.424987 3568.585185 2924.264788 0.819446542 -0.28727826 0.366511649 1 55.38959559 47.34397851 79139 derlin 1 "GO:0000839,GO:0002020,GO:0005047,GO:0005515,GO:0005769,GO:0005770,GO:0005783,GO:0005789,GO:0006457,GO:0006986,GO:0016020,GO:0016021,GO:0016032,GO:0016567,GO:0030176,GO:0030433,GO:0030968,GO:0030970,GO:0031398,GO:0031625,GO:0031648,GO:0032092,GO:0036502,GO:0036503,GO:0036513,GO:0038023,GO:0042288,GO:0042802,GO:0044322,GO:0044877,GO:0045184,GO:0051117,GO:0051787,GO:0055085,GO:0071712,GO:1990381" "Hrd1p ubiquitin ligase ERAD-L complex|protease binding|signal recognition particle binding|protein binding|early endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|response to unfolded protein|membrane|integral component of membrane|viral process|protein ubiquitination|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein destabilization|positive regulation of protein binding|Derlin-1-VIMP complex|ERAD pathway|Derlin-1 retrotranslocation complex|signaling receptor activity|MHC class I protein binding|identical protein binding|endoplasmic reticulum quality control compartment|protein-containing complex binding|establishment of protein localization|ATPase binding|misfolded protein binding|transmembrane transport|ER-associated misfolded protein catabolic process|ubiquitin-specific protease binding" "hsa04141,hsa05014,hsa05022" Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases DERL2 754.8226523 849.5181455 660.1271591 0.777060693 -0.363900808 0.327862722 1 10.3251973 8.368916411 51009 derlin 2 "GO:0000839,GO:0001967,GO:0005047,GO:0005515,GO:0005769,GO:0005770,GO:0005783,GO:0005789,GO:0008284,GO:0016020,GO:0016032,GO:0030176,GO:0030307,GO:0030433,GO:0030968,GO:0030970,GO:0044322,GO:0044877,GO:0051787,GO:1904153,GO:1904380,GO:1990381" "Hrd1p ubiquitin ligase ERAD-L complex|suckling behavior|signal recognition particle binding|protein binding|early endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum membrane|positive regulation of cell population proliferation|membrane|viral process|integral component of endoplasmic reticulum membrane|positive regulation of cell growth|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|endoplasmic reticulum quality control compartment|protein-containing complex binding|misfolded protein binding|negative regulation of retrograde protein transport, ER to cytosol|endoplasmic reticulum mannose trimming|ubiquitin-specific protease binding" hsa04141 Protein processing in endoplasmic reticulum DERL3 3.448425458 0 6.896850916 Inf Inf 0.09953452 1 0 0.10333172 91319 derlin 3 "GO:0000839,GO:0005047,GO:0005515,GO:0018279,GO:0030176,GO:0030433,GO:0030968,GO:0044877,GO:0051787,GO:1904153,GO:1990381" "Hrd1p ubiquitin ligase ERAD-L complex|signal recognition particle binding|protein binding|protein N-linked glycosylation via asparagine|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|protein-containing complex binding|misfolded protein binding|negative regulation of retrograde protein transport, ER to cytosol|ubiquitin-specific protease binding" hsa04141 Protein processing in endoplasmic reticulum DESI1 1023.691712 1077.883238 969.5001859 0.899448244 -0.152887827 0.664524117 1 11.59044235 10.87406987 27351 desumoylating isopeptidase 1 "GO:0005515,GO:0005634,GO:0005829,GO:0006611,GO:0016926,GO:0032434,GO:0032991,GO:0042802,GO:0061676,GO:0070140,GO:0070646" protein binding|nucleus|cytosol|protein export from nucleus|protein desumoylation|regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|identical protein binding|importin-alpha family protein binding|SUMO-specific isopeptidase activity|protein modification by small protein removal DESI2 1770.938813 1645.243625 1896.634002 1.152798268 0.205140074 0.529009883 1 13.90153245 16.71598309 51029 desumoylating isopeptidase 2 "GO:0004843,GO:0005515,GO:0005737,GO:0016579,GO:0018215,GO:0061578,GO:0070536,GO:0070646,GO:0071108,GO:0101005,GO:1990380" thiol-dependent ubiquitin-specific protease activity|protein binding|cytoplasm|protein deubiquitination|protein phosphopantetheinylation|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein modification by small protein removal|protein K48-linked deubiquitination|ubiquitinyl hydrolase activity|Lys48-specific deubiquitinase activity DET1 147.0607356 152.2433953 141.878076 0.931916132 -0.10172797 0.875153328 1 3.033277296 2.948525403 55070 DET1 partner of COP1 E3 ubiquitin ligase "GO:0005515,GO:0005634,GO:0016567,GO:0031461,GO:0031464,GO:0031625,GO:0032436,GO:0044877,GO:0065003,GO:0080008,GO:1990756" protein binding|nucleus|protein ubiquitination|cullin-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex binding|protein-containing complex assembly|Cul4-RING E3 ubiquitin ligase complex|ubiquitin ligase-substrate adaptor activity hsa04120 Ubiquitin mediated proteolysis DEXI 369.9516966 369.4439725 370.4594206 1.002748585 0.00395993 0.99989533 1 11.92545181 12.47334197 28955 Dexi homolog GO:0005515 protein binding DFFA 2363.307644 2367.892274 2358.723013 0.99612767 -0.005597436 0.987513157 1 16.22806364 16.86155547 1676 DNA fragmentation factor subunit alpha "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006309,GO:0019904,GO:0032076,GO:0032991,GO:0042981,GO:0043065,GO:0044183,GO:0060703,GO:0061077,GO:0070242,GO:1900118,GO:1902511" chromatin|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|apoptotic DNA fragmentation|protein domain specific binding|negative regulation of deoxyribonuclease activity|protein-containing complex|regulation of apoptotic process|positive regulation of apoptotic process|protein folding chaperone|deoxyribonuclease inhibitor activity|chaperone-mediated protein folding|thymocyte apoptotic process|negative regulation of execution phase of apoptosis|negative regulation of apoptotic DNA fragmentation hsa04210 Apoptosis DFFB 168.988931 169.4976467 168.4802152 0.993997371 -0.008686059 0.999786135 1 2.655260704 2.753013453 1677 DNA fragmentation factor subunit beta "GO:0000785,GO:0004536,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006308,GO:0006309,GO:0019899,GO:0019904,GO:0030263,GO:0032991,GO:0042802,GO:0097718" chromatin|deoxyribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA catabolic process|apoptotic DNA fragmentation|enzyme binding|protein domain specific binding|apoptotic chromosome condensation|protein-containing complex|identical protein binding|disordered domain specific binding hsa04210 Apoptosis DGAT1 913.2936008 939.8492267 886.7379749 0.943489604 -0.083921473 0.817190565 1 12.33801134 12.14222326 8694 diacylglycerol O-acyltransferase 1 "GO:0003846,GO:0004144,GO:0005515,GO:0005789,GO:0005886,GO:0006640,GO:0006641,GO:0008374,GO:0016021,GO:0016746,GO:0019432,GO:0019915,GO:0034379,GO:0035336,GO:0035579,GO:0036155,GO:0042572,GO:0042802,GO:0043312,GO:0046339,GO:0050252,GO:0055089" "2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity|protein binding|endoplasmic reticulum membrane|plasma membrane|monoacylglycerol biosynthetic process|triglyceride metabolic process|O-acyltransferase activity|integral component of membrane|transferase activity, transferring acyl groups|triglyceride biosynthetic process|lipid storage|very-low-density lipoprotein particle assembly|long-chain fatty-acyl-CoA metabolic process|specific granule membrane|acylglycerol acyl-chain remodeling|retinol metabolic process|identical protein binding|neutrophil degranulation|diacylglycerol metabolic process|retinol O-fatty-acyltransferase activity|fatty acid homeostasis" "hsa00561,hsa00830,hsa04975" Glycerolipid metabolism|Retinol metabolism|Fat digestion and absorption DGAT2 61.12548795 70.03196182 52.21901408 0.745645456 -0.423438283 0.60390916 1 1.423874672 1.107439653 84649 diacylglycerol O-acyltransferase 2 "GO:0003846,GO:0004144,GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0006071,GO:0006629,GO:0006640,GO:0006651,GO:0008374,GO:0010867,GO:0016021,GO:0019432,GO:0019915,GO:0030176,GO:0034383,GO:0035336,GO:0035356,GO:0036155,GO:0038183,GO:0042572,GO:0042632,GO:0042803,GO:0043231,GO:0045722,GO:0046322,GO:0046339,GO:0048471,GO:0050252,GO:0050746,GO:0055089,GO:0060613,GO:0071400,GO:0090181,GO:0097006,GO:1990578" 2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cytosol|glycerol metabolic process|lipid metabolic process|monoacylglycerol biosynthetic process|diacylglycerol biosynthetic process|O-acyltransferase activity|positive regulation of triglyceride biosynthetic process|integral component of membrane|triglyceride biosynthetic process|lipid storage|integral component of endoplasmic reticulum membrane|low-density lipoprotein particle clearance|long-chain fatty-acyl-CoA metabolic process|cellular triglyceride homeostasis|acylglycerol acyl-chain remodeling|bile acid signaling pathway|retinol metabolic process|cholesterol homeostasis|protein homodimerization activity|intracellular membrane-bounded organelle|positive regulation of gluconeogenesis|negative regulation of fatty acid oxidation|diacylglycerol metabolic process|perinuclear region of cytoplasm|retinol O-fatty-acyltransferase activity|regulation of lipoprotein metabolic process|fatty acid homeostasis|fat pad development|cellular response to oleic acid|regulation of cholesterol metabolic process|regulation of plasma lipoprotein particle levels|perinuclear endoplasmic reticulum membrane "hsa00561,hsa04975" Glycerolipid metabolism|Fat digestion and absorption DGCR2 2731.98112 2852.026271 2611.935968 0.91581764 -0.126867741 0.690939748 1 32.54733422 31.0914057 9993 DiGeorge syndrome critical region gene 2 "GO:0007155,GO:0009887,GO:0016020,GO:0016021,GO:0030246,GO:0050890" cell adhesion|animal organ morphogenesis|membrane|integral component of membrane|carbohydrate binding|cognition DGCR6L 687.9152305 653.6316436 722.1988173 1.104901858 0.143918229 0.706566297 1 28.24585058 32.5532453 85359 DiGeorge syndrome critical region gene 6 like "GO:0005515,GO:0005634" protein binding|nucleus DGCR8 1008.610387 1124.571213 892.6495614 0.793768817 -0.333209207 0.343848689 1 13.59321353 11.25465282 54487 DGCR8 microprocessor complex subunit "GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0010586,GO:0016604,GO:0020037,GO:0031053,GO:0042802,GO:0042803,GO:0046872,GO:0070877,GO:0070878,GO:0140517" double-stranded RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|miRNA metabolic process|nuclear body|heme binding|primary miRNA processing|identical protein binding|protein homodimerization activity|metal ion binding|microprocessor complex|primary miRNA binding|protein-RNA adaptor activity DGKA 787.1894041 637.3923481 936.9864601 1.47003092 0.555846501 0.131831602 1 8.426435356 12.92070744 1606 diacylglycerol kinase alpha "GO:0003951,GO:0004143,GO:0005509,GO:0005524,GO:0005543,GO:0005829,GO:0005886,GO:0006654,GO:0007205,GO:0008289,GO:0016020,GO:0016301,GO:0030168,GO:0035556,GO:0046339,GO:0046486,GO:0046834" NAD+ kinase activity|diacylglycerol kinase activity|calcium ion binding|ATP binding|phospholipid binding|cytosol|plasma membrane|phosphatidic acid biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|lipid binding|membrane|kinase activity|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKD 701.5820013 745.9926368 657.1713658 0.880935459 -0.18289177 0.629807504 1 3.774792222 3.468590838 8527 diacylglycerol kinase delta "GO:0003951,GO:0004143,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005905,GO:0006654,GO:0006897,GO:0007165,GO:0007173,GO:0007205,GO:0007275,GO:0010033,GO:0015031,GO:0019900,GO:0019932,GO:0019992,GO:0030168,GO:0035556,GO:0042802,GO:0042803,GO:0045742,GO:0046339,GO:0046834,GO:0046872,GO:0046982,GO:0090038,GO:2000370" NAD+ kinase activity|diacylglycerol kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|clathrin-coated pit|phosphatidic acid biosynthetic process|endocytosis|signal transduction|epidermal growth factor receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|multicellular organism development|response to organic substance|protein transport|kinase binding|second-messenger-mediated signaling|diacylglycerol binding|platelet activation|intracellular signal transduction|identical protein binding|protein homodimerization activity|positive regulation of epidermal growth factor receptor signaling pathway|diacylglycerol metabolic process|lipid phosphorylation|metal ion binding|protein heterodimerization activity|negative regulation of protein kinase C signaling|positive regulation of clathrin-dependent endocytosis "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKE 624.7543874 646.5269519 602.9818229 0.93264762 -0.100596001 0.79830749 1 3.621356923 3.522936761 8526 diacylglycerol kinase epsilon "GO:0003951,GO:0004143,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006654,GO:0006661,GO:0007205,GO:0016020,GO:0016021,GO:0016301,GO:0030168,GO:0035556,GO:0046339,GO:0046834,GO:0046872,GO:0050804,GO:0098978" NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|phosphatidic acid biosynthetic process|phosphatidylinositol biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|membrane|integral component of membrane|kinase activity|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|lipid phosphorylation|metal ion binding|modulation of chemical synaptic transmission|glutamatergic synapse "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKG 88.82893621 111.6451565 66.01271591 0.591272546 -0.758104804 0.28344317 1 0.974566239 0.601056096 1608 diacylglycerol kinase gamma "GO:0003951,GO:0004143,GO:0005509,GO:0005524,GO:0005829,GO:0005856,GO:0005886,GO:0006654,GO:0007205,GO:0008289,GO:0016020,GO:0030168,GO:0035556,GO:0046339,GO:0046486,GO:0046834,GO:0048666,GO:0050773,GO:0090038" NAD+ kinase activity|diacylglycerol kinase activity|calcium ion binding|ATP binding|cytosol|cytoskeleton|plasma membrane|phosphatidic acid biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|lipid binding|membrane|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation|neuron development|regulation of dendrite development|negative regulation of protein kinase C signaling "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKH 846.6182682 827.1891142 866.0474221 1.046976329 0.066228825 0.858236633 1 2.36770716 2.585715745 160851 diacylglycerol kinase eta "GO:0003951,GO:0004143,GO:0005524,GO:0005737,GO:0005768,GO:0005886,GO:0006654,GO:0007205,GO:0015629,GO:0030168,GO:0035556,GO:0043231,GO:0046339,GO:0046473,GO:0046834,GO:0046872" NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|cytoplasm|endosome|plasma membrane|phosphatidic acid biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|actin cytoskeleton|platelet activation|intracellular signal transduction|intracellular membrane-bounded organelle|diacylglycerol metabolic process|phosphatidic acid metabolic process|lipid phosphorylation|metal ion binding "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKQ 276.6890705 257.798816 295.579325 1.146550359 0.197299722 0.688696094 1 2.72182626 3.255138443 1609 diacylglycerol kinase theta "GO:0003951,GO:0004143,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0005856,GO:0005886,GO:0006111,GO:0006357,GO:0006654,GO:0007171,GO:0007186,GO:0007205,GO:0008277,GO:0010628,GO:0010629,GO:0010801,GO:0012506,GO:0016363,GO:0016607,GO:0018105,GO:0019900,GO:0019933,GO:0030168,GO:0030297,GO:0033198,GO:0033613,GO:0035556,GO:0043274,GO:0046339,GO:0046486,GO:0046834,GO:0046872,GO:0050731,GO:0051591,GO:0070493,GO:0070528,GO:0090181,GO:0098793,GO:0098794,GO:0098978,GO:1900242,GO:1903432,GO:2000064,GO:2000182" NAD+ kinase activity|diacylglycerol kinase activity|protein binding|ATP binding|nucleus|cytoplasm|endosome|cytosol|cytoskeleton|plasma membrane|regulation of gluconeogenesis|regulation of transcription by RNA polymerase II|phosphatidic acid biosynthetic process|activation of transmembrane receptor protein tyrosine kinase activity|G protein-coupled receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|positive regulation of gene expression|negative regulation of gene expression|negative regulation of peptidyl-threonine phosphorylation|vesicle membrane|nuclear matrix|nuclear speck|peptidyl-serine phosphorylation|kinase binding|cAMP-mediated signaling|platelet activation|transmembrane receptor protein tyrosine kinase activator activity|response to ATP|activating transcription factor binding|intracellular signal transduction|phospholipase binding|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|response to cAMP|thrombin-activated receptor signaling pathway|protein kinase C signaling|regulation of cholesterol metabolic process|presynapse|postsynapse|glutamatergic synapse|regulation of synaptic vesicle endocytosis|regulation of TORC1 signaling|regulation of cortisol biosynthetic process|regulation of progesterone biosynthetic process "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKZ 1104.047424 1115.436609 1092.658238 0.979578964 -0.029766302 0.93424437 1 9.864314516 10.07911246 8525 diacylglycerol kinase zeta "GO:0003951,GO:0004143,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006654,GO:0007205,GO:0014069,GO:0016301,GO:0016477,GO:0016607,GO:0030027,GO:0030168,GO:0035556,GO:0046339,GO:0046486,GO:0046834,GO:0046872,GO:0050860,GO:0051966,GO:0090216,GO:0098978" "NAD+ kinase activity|diacylglycerol kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|phosphatidic acid biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|postsynaptic density|kinase activity|cell migration|nuclear speck|lamellipodium|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation|metal ion binding|negative regulation of T cell receptor signaling pathway|regulation of synaptic transmission, glutamatergic|positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity|glutamatergic synapse" "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGLUCY 462.0927246 505.4480723 418.737377 0.828447866 -0.271517182 0.516437564 1 5.85793175 5.062038232 80017 D-glutamate cyclase "GO:0003674,GO:0005515,GO:0005575,GO:0005759,GO:0006536,GO:0008150,GO:0047820" molecular_function|protein binding|cellular_component|mitochondrial matrix|glutamate metabolic process|biological_process|D-glutamate cyclase activity hsa00471 D-Glutamine and D-glutamate metabolism DGUOK 734.5762351 711.4841338 757.6683363 1.064912484 0.090734873 0.811153556 1 30.2046617 33.55087292 1716 deoxyguanosine kinase "GO:0004136,GO:0004138,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006170,GO:0006468,GO:0006754,GO:0008617,GO:0010977,GO:0019136,GO:0042775,GO:0043101,GO:0046070,GO:0046122" deoxyadenosine kinase activity|deoxyguanosine kinase activity|ATP binding|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|dAMP biosynthetic process|protein phosphorylation|ATP biosynthetic process|guanosine metabolic process|negative regulation of neuron projection development|deoxynucleoside kinase activity|mitochondrial ATP synthesis coupled electron transport|purine-containing compound salvage|dGTP metabolic process|purine deoxyribonucleoside metabolic process hsa00230 Purine metabolism DHCR24 5608.93541 5275.741124 5942.129696 1.126311841 0.17160632 0.595421297 1 63.12253159 74.15816721 1718 24-dehydrocholesterol reductase "GO:0000139,GO:0000246,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0006695,GO:0006915,GO:0006979,GO:0007050,GO:0008202,GO:0009888,GO:0016020,GO:0016021,GO:0016628,GO:0019899,GO:0033489,GO:0033490,GO:0042605,GO:0043066,GO:0043154,GO:0043588,GO:0050614,GO:0055114,GO:0071949,GO:1901214" "Golgi membrane|delta24(24-1) sterol reductase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|apoptotic process|response to oxidative stress|cell cycle arrest|steroid metabolic process|tissue development|membrane|integral component of membrane|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|enzyme binding|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|peptide antigen binding|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|skin development|delta24-sterol reductase activity|oxidation-reduction process|FAD binding|regulation of neuron death" hsa00100 Steroid biosynthesis DHCR7 825.0463715 834.293806 815.7989369 0.977831708 -0.032341907 0.932833432 1 15.30388919 15.60924359 1717 7-dehydrocholesterol reductase "GO:0005515,GO:0005640,GO:0005783,GO:0005789,GO:0006695,GO:0009918,GO:0016020,GO:0016126,GO:0016132,GO:0016627,GO:0030176,GO:0033489,GO:0033490,GO:0045540,GO:0047598,GO:0050661,GO:0055114" "protein binding|nuclear outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|sterol delta7 reductase activity|membrane|sterol biosynthetic process|brassinosteroid biosynthetic process|oxidoreductase activity, acting on the CH-CH group of donors|integral component of endoplasmic reticulum membrane|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|regulation of cholesterol biosynthetic process|7-dehydrocholesterol reductase activity|NADP binding|oxidation-reduction process" hsa00100 Steroid biosynthesis DHDDS 419.4470066 452.6703619 386.2236513 0.853211705 -0.229024337 0.594866303 1 6.917971305 6.1567496 79947 dehydrodolichyl diphosphate synthase subunit "GO:0002094,GO:0005515,GO:0005783,GO:0005789,GO:0006489,GO:0016094,GO:0045547,GO:0046872,GO:1904423" polyprenyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|dolichyl diphosphate biosynthetic process|polyprenol biosynthetic process|dehydrodolichyl diphosphate synthase activity|metal ion binding|dehydrodolichyl diphosphate synthase complex hsa00900 Terpenoid backbone biosynthesis DHDH 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.087869982 0.059315856 27294 dihydrodiol dehydrogenase "GO:0005975,GO:0008746,GO:0009055,GO:0022900,GO:0042843,GO:0047115,GO:0047837" "carbohydrate metabolic process|NAD(P)+ transhydrogenase activity|electron transfer activity|electron transport chain|D-xylose catabolic process|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|D-xylose 1-dehydrogenase (NADP+) activity" "hsa00040,hsa00980" Pentose and glucuronate interconversions|Metabolism of xenobiotics by cytochrome P450 DHFR 1285.561484 1097.167402 1473.955567 1.34341903 0.425909371 0.20853051 1 14.17904014 19.86891985 1719 dihydrofolate reductase "GO:0000083,GO:0000900,GO:0003729,GO:0004146,GO:0005542,GO:0005739,GO:0005829,GO:0006545,GO:0006729,GO:0006730,GO:0008144,GO:0017148,GO:0031103,GO:0031427,GO:0046452,GO:0046653,GO:0046654,GO:0046655,GO:0050661,GO:0051000,GO:0051870,GO:0055114,GO:0070402,GO:1990825,GO:2000121" "regulation of transcription involved in G1/S transition of mitotic cell cycle|translation repressor activity, mRNA regulatory element binding|mRNA binding|dihydrofolate reductase activity|folic acid binding|mitochondrion|cytosol|glycine biosynthetic process|tetrahydrobiopterin biosynthetic process|one-carbon metabolic process|drug binding|negative regulation of translation|axon regeneration|response to methotrexate|dihydrofolate metabolic process|tetrahydrofolate metabolic process|tetrahydrofolate biosynthetic process|folic acid metabolic process|NADP binding|positive regulation of nitric-oxide synthase activity|methotrexate binding|oxidation-reduction process|NADPH binding|sequence-specific mRNA binding|regulation of removal of superoxide radicals" "hsa00670,hsa00790,hsa01523" One carbon pool by folate|Folate biosynthesis|Antifolate resistance DHFR2 173.1054163 215.1706653 131.0401674 0.609005727 -0.7154723 0.205961437 1 2.718292622 1.726766095 200895 dihydrofolate reductase 2 "GO:0003729,GO:0004146,GO:0005739,GO:0005743,GO:0005759,GO:0006545,GO:0006730,GO:0046105,GO:0046452,GO:0046653,GO:0046654,GO:0046655,GO:0050661,GO:0055114" mRNA binding|dihydrofolate reductase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|glycine biosynthetic process|one-carbon metabolic process|thymidine biosynthetic process|dihydrofolate metabolic process|tetrahydrofolate metabolic process|tetrahydrofolate biosynthetic process|folic acid metabolic process|NADP binding|oxidation-reduction process "hsa00670,hsa00790,hsa01523" One carbon pool by folate|Folate biosynthesis|Antifolate resistance DHH 7.030462899 9.134603715 4.926322083 0.539303317 -0.890831188 0.625563046 1 0.084391728 0.047473243 50846 desert hedgehog signaling molecule "GO:0001649,GO:0001708,GO:0005113,GO:0005509,GO:0005515,GO:0005615,GO:0005886,GO:0007224,GO:0007267,GO:0007286,GO:0008233,GO:0008270,GO:0010468,GO:0016540,GO:0030238,GO:0032355,GO:0033327,GO:0042552,GO:0043627,GO:0050810" osteoblast differentiation|cell fate specification|patched binding|calcium ion binding|protein binding|extracellular space|plasma membrane|smoothened signaling pathway|cell-cell signaling|spermatid development|peptidase activity|zinc ion binding|regulation of gene expression|protein autoprocessing|male sex determination|response to estradiol|Leydig cell differentiation|myelination|response to estrogen|regulation of steroid biosynthetic process hsa04340 Hedgehog signaling pathway DHODH 112.8909639 140.0639236 85.71800424 0.611992025 -0.708415242 0.277545047 1 2.387661937 1.524173929 1723 dihydroorotate dehydrogenase (quinone) "GO:0004152,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005829,GO:0006207,GO:0007565,GO:0007595,GO:0008144,GO:0009220,GO:0010181,GO:0016021,GO:0031000,GO:0042493,GO:0042594,GO:0043025,GO:0043065,GO:0044205,GO:0046134,GO:0048039,GO:0055114,GO:0090140,GO:1903576" dihydroorotate dehydrogenase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|cytosol|'de novo' pyrimidine nucleobase biosynthetic process|female pregnancy|lactation|drug binding|pyrimidine ribonucleotide biosynthetic process|FMN binding|integral component of membrane|response to caffeine|response to drug|response to starvation|neuronal cell body|positive regulation of apoptotic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process|ubiquinone binding|oxidation-reduction process|regulation of mitochondrial fission|response to L-arginine hsa00240 Pyrimidine metabolism DHPS 1131.420305 999.7316288 1263.108982 1.263448055 0.337366351 0.32864677 1 30.08489611 39.64805043 1725 deoxyhypusine synthase "GO:0005515,GO:0005737,GO:0005829,GO:0006412,GO:0008216,GO:0008284,GO:0008612,GO:0034038,GO:0042802" protein binding|cytoplasm|cytosol|translation|spermidine metabolic process|positive regulation of cell population proliferation|peptidyl-lysine modification to peptidyl-hypusine|deoxyhypusine synthase activity|identical protein binding DHRS1 637.0162527 575.4800341 698.5524713 1.213860482 0.279602611 0.46934808 1 17.43183825 22.07129878 115817 dehydrogenase/reductase 1 "GO:0005515,GO:0005783,GO:0016491,GO:0055114" protein binding|endoplasmic reticulum|oxidoreductase activity|oxidation-reduction process DHRS11 139.6888199 119.7648043 159.6128355 1.332719044 0.414372672 0.497963616 1 3.918388134 5.44705783 79154 dehydrogenase/reductase 11 "GO:0000166,GO:0000253,GO:0004303,GO:0005575,GO:0005576,GO:0006694,GO:0006703,GO:0055114,GO:0072555,GO:0072582" nucleotide binding|3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity|cellular_component|extracellular region|steroid biosynthetic process|estrogen biosynthetic process|oxidation-reduction process|17-beta-ketosteroid reductase activity|17-beta-hydroxysteroid dehydrogenase (NADP+) activity hsa00140 Steroid hormone biosynthesis DHRS12 67.36640312 58.86744617 75.86536007 1.288748961 0.365971264 0.645303507 1 1.137081799 1.528537035 79758 dehydrogenase/reductase 12 "GO:0016491,GO:0055114" oxidoreductase activity|oxidation-reduction process DHRS13 363.8510743 491.2386887 236.46346 0.481361638 -1.054806923 0.018710944 0.589604582 12.89761876 6.475852405 147015 dehydrogenase/reductase 13 "GO:0005576,GO:0005743,GO:0016020,GO:0042572,GO:0042574,GO:0052650,GO:0055114" extracellular region|mitochondrial inner membrane|membrane|retinol metabolic process|retinal metabolic process|NADP-retinol dehydrogenase activity|oxidation-reduction process DHRS2 23.04707175 26.38885518 19.70528833 0.74672767 -0.421345905 0.719107993 1 0.520039852 0.405055749 10202 dehydrogenase/reductase 2 "GO:0004090,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0008207,GO:0008285,GO:0009636,GO:0034599,GO:0043011,GO:0043066,GO:0055114" carbonyl reductase (NADPH) activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|C21-steroid hormone metabolic process|negative regulation of cell population proliferation|response to toxic substance|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptotic process|oxidation-reduction process DHRS3 2586.756309 2151.706653 3021.805966 1.404376364 0.489929621 0.12478764 1 44.99436466 65.91094905 9249 dehydrogenase/reductase 3 "GO:0000166,GO:0001523,GO:0003151,GO:0004745,GO:0005789,GO:0005811,GO:0007601,GO:0009055,GO:0016021,GO:0016616,GO:0022900,GO:0030278,GO:0042572,GO:0042622,GO:0048385,GO:0048387,GO:0052650,GO:0060021,GO:0060349,GO:0060411" "nucleotide binding|retinoid metabolic process|outflow tract morphogenesis|retinol dehydrogenase activity|endoplasmic reticulum membrane|lipid droplet|visual perception|electron transfer activity|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|electron transport chain|regulation of ossification|retinol metabolic process|photoreceptor outer segment membrane|regulation of retinoic acid receptor signaling pathway|negative regulation of retinoic acid receptor signaling pathway|NADP-retinol dehydrogenase activity|roof of mouth development|bone morphogenesis|cardiac septum morphogenesis" hsa00830 Retinol metabolism DHRS4 278.1399971 222.2753571 334.0046372 1.502661571 0.587520122 0.225576555 1 8.394826768 13.15796868 10901 dehydrogenase/reductase 4 "GO:0000253,GO:0004090,GO:0005634,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0005789,GO:0005829,GO:0006066,GO:0006625,GO:0008202,GO:0016655,GO:0018455,GO:0042180,GO:0042802,GO:0055114" "3-keto sterol reductase activity|carbonyl reductase (NADPH) activity|nucleus|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|endoplasmic reticulum membrane|cytosol|alcohol metabolic process|protein targeting to peroxisome|steroid metabolic process|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|alcohol dehydrogenase [NAD(P)+] activity|cellular ketone metabolic process|identical protein binding|oxidation-reduction process" "hsa00830,hsa04146" Retinol metabolism|Peroxisome DHRS4L2 195.0687465 167.4677348 222.6697581 1.329627814 0.411022467 0.45157693 1 4.622152575 6.410476293 317749 dehydrogenase/reductase 4 like 2 "GO:0005576,GO:0016491,GO:0055114" extracellular region|oxidoreductase activity|oxidation-reduction process hsa00830 Retinol metabolism DHRS7 1200.199779 1121.526345 1278.873213 1.140297077 0.189409732 0.580608541 1 21.9819477 26.14569021 51635 dehydrogenase/reductase 7 "GO:0005515,GO:0016020,GO:0016491,GO:0055114" protein binding|membrane|oxidoreductase activity|oxidation-reduction process DHRS7B 212.8129085 235.4697847 190.1560324 0.807560225 -0.308358239 0.562744077 1 4.810695404 4.052273133 25979 dehydrogenase/reductase 7B "GO:0003674,GO:0005789,GO:0008150,GO:0016020,GO:0016021,GO:0016491,GO:0055114" molecular_function|endoplasmic reticulum membrane|biological_process|membrane|integral component of membrane|oxidoreductase activity|oxidation-reduction process DHRSX-2 9.49362394 9.134603715 9.852644165 1.078606634 0.109168812 1 1 0.179385596 0.201821108 207063 dehydrogenase/reductase X-linked DHTKD1 1687.056488 1467.62633 1906.486646 1.299027284 0.377431733 0.248707057 1 14.36885679 19.46957264 55526 dehydrogenase E1 and transketolase domain containing 1 "GO:0002244,GO:0004591,GO:0005515,GO:0005739,GO:0005759,GO:0006091,GO:0006096,GO:0006099,GO:0030976" hematopoietic progenitor cell differentiation|oxoglutarate dehydrogenase (succinyl-transferring) activity|protein binding|mitochondrion|mitochondrial matrix|generation of precursor metabolites and energy|glycolytic process|tricarboxylic acid cycle|thiamine pyrophosphate binding "hsa00310,hsa00380" Lysine degradation|Tryptophan metabolism DHX15 3030.008514 3221.470244 2838.546784 0.881133945 -0.182566749 0.566314734 1 54.42164882 50.01837263 1665 DEAH-box helicase 15 "GO:0000398,GO:0003723,GO:0003724,GO:0003725,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005681,GO:0005689,GO:0005730,GO:0006397,GO:0008380,GO:0009636,GO:0016607,GO:0043279,GO:0071008" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|double-stranded RNA binding|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|nucleolus|mRNA processing|RNA splicing|response to toxic substance|nuclear speck|response to alkaloid|U2-type post-mRNA release spliceosomal complex" hsa03040 Spliceosome DHX16 1273.169967 1294.06886 1252.271073 0.967700493 -0.047367498 0.891056896 1 13.24843795 13.37277594 8449 DEAH-box helicase 16 "GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005681,GO:0008380,GO:0016887,GO:0071005" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|spliceosomal complex|RNA splicing|ATPase activity|U2-type precatalytic spliceosome" hsa03040 Spliceosome DHX29 985.5120971 993.641893 977.3823012 0.983636366 -0.02380302 0.949318565 1 10.59239245 10.86787337 54505 DExH-box helicase 29 "GO:0001731,GO:0003723,GO:0003724,GO:0003743,GO:0005524,GO:0005622,GO:0008494,GO:0016282,GO:0017111,GO:0022627,GO:0042255,GO:0043024,GO:0045296,GO:0045948" formation of translation preinitiation complex|RNA binding|RNA helicase activity|translation initiation factor activity|ATP binding|intracellular anatomical structure|translation activator activity|eukaryotic 43S preinitiation complex|nucleoside-triphosphatase activity|cytosolic small ribosomal subunit|ribosome assembly|ribosomal small subunit binding|cadherin binding|positive regulation of translational initiation DHX30 2512.152594 2608.436839 2415.868349 0.926174755 -0.110643662 0.729428691 1 26.3531067 25.45896178 22907 DExH-box helicase 30 "GO:0003682,GO:0003723,GO:0003724,GO:0003725,GO:0005515,GO:0005524,GO:0005622,GO:0005737,GO:0005739,GO:0005829,GO:0007417,GO:0035770,GO:0042645,GO:1902775" chromatin binding|RNA binding|RNA helicase activity|double-stranded RNA binding|protein binding|ATP binding|intracellular anatomical structure|cytoplasm|mitochondrion|cytosol|central nervous system development|ribonucleoprotein granule|mitochondrial nucleoid|mitochondrial large ribosomal subunit assembly DHX32 742.4529072 778.4712277 706.4345867 0.907463965 -0.14008774 0.709433677 1 12.92682669 12.23593734 55760 DEAH-box helicase 32 (putative) "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0005681,GO:0005739" RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|spliceosomal complex|mitochondrion DHX33 1435.313265 1568.106971 1302.519559 0.830631827 -0.267718943 0.422243506 1 14.70179307 12.73781107 56919 DEAH-box helicase 33 "GO:0000182,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006413,GO:0032481,GO:0033613,GO:0043023,GO:0043410,GO:0045943,GO:0051092,GO:0072559,GO:1900227" rDNA binding|RNA binding|RNA helicase activity|double-stranded RNA binding|mRNA binding|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|nucleolus|cytoplasm|translational initiation|positive regulation of type I interferon production|activating transcription factor binding|ribosomal large subunit binding|positive regulation of MAPK cascade|positive regulation of transcription by RNA polymerase I|positive regulation of NF-kappaB transcription factor activity|NLRP3 inflammasome complex|positive regulation of NLRP3 inflammasome complex assembly hsa04621 NOD-like receptor signaling pathway DHX34 504.2876262 594.7641975 413.8110549 0.695756498 -0.523345618 0.199475108 1 5.196258133 3.771064129 9704 DExH-box helicase 34 "GO:0000184,GO:0000956,GO:0003723,GO:0003724,GO:0005524,GO:0005622,GO:0016020,GO:2000623" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process|RNA binding|RNA helicase activity|ATP binding|intracellular anatomical structure|membrane|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" DHX35 637.1862372 688.1401466 586.2323278 0.851908337 -0.231229886 0.550105639 1 10.00915302 8.89418435 60625 DEAH-box helicase 35 "GO:0000398,GO:0001701,GO:0003723,GO:0003724,GO:0005524,GO:0005622,GO:0071013" "mRNA splicing, via spliceosome|in utero embryonic development|RNA binding|RNA helicase activity|ATP binding|intracellular anatomical structure|catalytic step 2 spliceosome" DHX36 962.7861892 1056.569163 869.0032154 0.822476413 -0.281953789 0.427146075 1 7.959467612 6.828469937 170506 DEAH-box helicase 36 "GO:0000287,GO:0000781,GO:0000976,GO:0000978,GO:0001503,GO:0002151,GO:0002735,GO:0003678,GO:0003697,GO:0003723,GO:0003724,GO:0003725,GO:0003730,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006359,GO:0007283,GO:0008094,GO:0010494,GO:0010501,GO:0010628,GO:0016607,GO:0017148,GO:0030424,GO:0030425,GO:0031442,GO:0032206,GO:0032481,GO:0032508,GO:0032727,GO:0034605,GO:0034644,GO:0035925,GO:0042826,GO:0043123,GO:0043204,GO:0043330,GO:0043488,GO:0044806,GO:0045087,GO:0045944,GO:0045995,GO:0048027,GO:0051607,GO:0051880,GO:0051891,GO:0060261,GO:0061003,GO:0061158,GO:0070034,GO:0070062,GO:0070883,GO:0090669,GO:1900153,GO:1901534,GO:1902064,GO:1903843,GO:1904358,GO:1904582,GO:2000767" "magnesium ion binding|chromosome, telomeric region|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|ossification|G-quadruplex RNA binding|positive regulation of myeloid dendritic cell cytokine production|DNA helicase activity|single-stranded DNA binding|RNA binding|RNA helicase activity|double-stranded RNA binding|mRNA 3'-UTR binding|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase III|spermatogenesis|DNA-dependent ATPase activity|cytoplasmic stress granule|RNA secondary structure unwinding|positive regulation of gene expression|nuclear speck|negative regulation of translation|axon|dendrite|positive regulation of mRNA 3'-end processing|positive regulation of telomere maintenance|positive regulation of type I interferon production|DNA duplex unwinding|positive regulation of interferon-alpha production|cellular response to heat|cellular response to UV|mRNA 3'-UTR AU-rich region binding|histone deacetylase binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|perikaryon|response to exogenous dsRNA|regulation of mRNA stability|G-quadruplex DNA unwinding|innate immune response|positive regulation of transcription by RNA polymerase II|regulation of embryonic development|mRNA 5'-UTR binding|defense response to virus|G-quadruplex DNA binding|positive regulation of cardioblast differentiation|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of dendritic spine morphogenesis|3'-UTR-mediated mRNA destabilization|telomerase RNA binding|extracellular exosome|pre-miRNA binding|telomerase RNA stabilization|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of hematopoietic progenitor cell differentiation|regulation of transcription from RNA polymerase II promoter involved in spermatogenesis|cellular response to arsenite ion|positive regulation of telomere maintenance via telomere lengthening|positive regulation of intracellular mRNA localization|positive regulation of cytoplasmic translation" hsa03018 RNA degradation DHX37 757.268246 881.9967365 632.5397554 0.717167909 -0.479617161 0.196825231 1 9.146196398 6.841909111 57647 DEAH-box helicase 37 "GO:0000462,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0007420,GO:0031965,GO:0034511,GO:0042254,GO:0042255,GO:2000020" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|nucleoplasm|nucleolus|cytoplasm|rRNA processing|brain development|nuclear membrane|U3 snoRNA binding|ribosome biogenesis|ribosome assembly|positive regulation of male gonad development" DHX38 1418.607069 1402.669148 1434.54499 1.022725132 0.032418459 0.924781152 1 16.10889888 17.18465087 9785 DEAH-box helicase 38 "GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005681,GO:0006405,GO:0006406,GO:0016020,GO:0031124,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|spliceosomal complex|RNA export from nucleus|mRNA export from nucleus|membrane|mRNA 3'-end processing|catalytic step 2 spliceosome" hsa03040 Spliceosome DHX40 995.9937071 969.2829498 1022.704464 1.055114468 0.077399524 0.82861679 1 17.15860258 18.88414922 79665 DEAH-box helicase 40 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622" RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure DHX57 611.30486 636.3773922 586.2323278 0.921202317 -0.118410056 0.763994894 1 6.3507921 6.102374366 90957 DExH-box helicase 57 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0046872" RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|metal ion binding DHX58 191.6621367 204.0061496 179.3181238 0.878983914 -0.186091332 0.740004186 1 3.976979134 3.646281291 79132 DExH-box helicase 58 "GO:0003677,GO:0003724,GO:0003725,GO:0003727,GO:0005515,GO:0005524,GO:0005737,GO:0008270,GO:0009615,GO:0009617,GO:0016032,GO:0032480,GO:0032481,GO:0032728,GO:0039534,GO:0039536,GO:0045087,GO:0045088,GO:0045824,GO:0051607,GO:1900245,GO:1900246" DNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|protein binding|ATP binding|cytoplasm|zinc ion binding|response to virus|response to bacterium|viral process|negative regulation of type I interferon production|positive regulation of type I interferon production|positive regulation of interferon-beta production|negative regulation of MDA-5 signaling pathway|negative regulation of RIG-I signaling pathway|innate immune response|regulation of innate immune response|negative regulation of innate immune response|defense response to virus|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway hsa04622 RIG-I-like receptor signaling pathway DHX8 2318.343263 2190.27498 2446.411546 1.116942653 0.159555115 0.618249962 1 16.20121234 18.87531985 1659 DEAH-box helicase 8 "GO:0000390,GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0006396,GO:0008380,GO:0016604,GO:0042802,GO:0071007,GO:0071013" "spliceosomal complex disassembly|mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|spliceosomal complex|cytosol|RNA processing|RNA splicing|nuclear body|identical protein binding|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome DHX9 5449.390868 6088.720854 4810.060882 0.789995304 -0.340084018 0.291910767 1 68.63392645 56.55607795 1660 DExH-box helicase 9 "GO:0000380,GO:0000398,GO:0000978,GO:0000993,GO:0001069,GO:0001085,GO:0001649,GO:0003677,GO:0003678,GO:0003688,GO:0003690,GO:0003697,GO:0003712,GO:0003713,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003729,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005726,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005844,GO:0006260,GO:0006353,GO:0006357,GO:0006954,GO:0010501,GO:0015629,GO:0016020,GO:0016442,GO:0016604,GO:0016887,GO:0017111,GO:0030423,GO:0031490,GO:0032481,GO:0032508,GO:0032727,GO:0032728,GO:0032741,GO:0032755,GO:0032760,GO:0032991,GO:0033679,GO:0034458,GO:0034622,GO:0035197,GO:0035613,GO:0036464,GO:0039695,GO:0042788,GO:0043138,GO:0044806,GO:0045087,GO:0045089,GO:0045142,GO:0045739,GO:0045740,GO:0045944,GO:0046833,GO:0046872,GO:0047429,GO:0048146,GO:0048511,GO:0050434,GO:0050684,GO:0050691,GO:0050729,GO:0051028,GO:0051092,GO:0060760,GO:0061676,GO:0070063,GO:0070269,GO:0070578,GO:0070922,GO:0070934,GO:0070937,GO:0071356,GO:0071360,GO:0097165,GO:1903608,GO:1904973,GO:1905172,GO:1905538,GO:1905698,GO:1990518,GO:1990825,GO:1990841,GO:1990904,GO:2000373,GO:2000637,GO:2000765,GO:2000767" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II complex binding|regulatory region RNA binding|RNA polymerase II transcription factor binding|osteoblast differentiation|DNA binding|DNA helicase activity|DNA replication origin binding|double-stranded DNA binding|single-stranded DNA binding|transcription coregulator activity|transcription coactivator activity|RNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|mRNA binding|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|perichromatin fibrils|nucleolus|cytoplasm|centrosome|cytosol|polysome|DNA replication|DNA-templated transcription, termination|regulation of transcription by RNA polymerase II|inflammatory response|RNA secondary structure unwinding|actin cytoskeleton|membrane|RISC complex|nuclear body|ATPase activity|nucleoside-triphosphatase activity|targeting of mRNA for destruction involved in RNA interference|chromatin DNA binding|positive regulation of type I interferon production|DNA duplex unwinding|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|protein-containing complex|3'-5' DNA/RNA helicase activity|3'-5' RNA helicase activity|cellular protein-containing complex assembly|siRNA binding|RNA stem-loop binding|cytoplasmic ribonucleoprotein granule|DNA-templated viral transcription|polysomal ribosome|3'-5' DNA helicase activity|G-quadruplex DNA unwinding|innate immune response|positive regulation of innate immune response|triplex DNA binding|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of transcription by RNA polymerase II|positive regulation of RNA export from nucleus|metal ion binding|nucleoside-triphosphate diphosphatase activity|positive regulation of fibroblast proliferation|rhythmic process|positive regulation of viral transcription|regulation of mRNA processing|regulation of defense response to virus by host|positive regulation of inflammatory response|mRNA transport|positive regulation of NF-kappaB transcription factor activity|positive regulation of response to cytokine stimulus|importin-alpha family protein binding|RNA polymerase binding|pyroptosis|RISC-loading complex|small RNA loading onto RISC|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|cellular response to tumor necrosis factor|cellular response to exogenous dsRNA|nuclear stress granule|protein localization to cytoplasmic stress granule|positive regulation of viral translation|RISC complex binding|polysome binding|positive regulation of polysome binding|single-stranded 3'-5' DNA helicase activity|sequence-specific mRNA binding|promoter-specific chromatin binding|ribonucleoprotein complex|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|positive regulation of gene silencing by miRNA|regulation of cytoplasmic translation|positive regulation of cytoplasmic translation" DIABLO 1124.693439 1112.391741 1136.995137 1.022117564 0.031561144 0.929850697 1 20.82762197 22.20529091 56616 diablo IAP-binding mitochondrial protein "GO:0005515,GO:0005739,GO:0005758,GO:0005829,GO:0006915,GO:0006919,GO:0008625,GO:0008631,GO:0008635,GO:0009898,GO:0035631,GO:0043065,GO:0051402,GO:0097193" protein binding|mitochondrion|mitochondrial intermembrane space|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to oxidative stress|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|cytoplasmic side of plasma membrane|CD40 receptor complex|positive regulation of apoptotic process|neuron apoptotic process|intrinsic apoptotic signaling pathway "hsa04210,hsa04215" Apoptosis|Apoptosis - multiple species DIAPH1 6722.843889 5920.238164 7525.449614 1.271139675 0.346122565 0.289615034 1 44.58575132 59.11603441 1729 diaphanous related formin 1 "GO:0003723,GO:0003779,GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005815,GO:0005829,GO:0005886,GO:0007010,GO:0007605,GO:0008360,GO:0030036,GO:0030041,GO:0030667,GO:0032587,GO:0032886,GO:0035372,GO:0043312,GO:0044325,GO:0051279,GO:0051493,GO:0071420,GO:0072686,GO:0101003,GO:2000145" RNA binding|actin binding|signaling receptor binding|protein binding|nucleus|cytoplasm|microtubule organizing center|cytosol|plasma membrane|cytoskeleton organization|sensory perception of sound|regulation of cell shape|actin cytoskeleton organization|actin filament polymerization|secretory granule membrane|ruffle membrane|regulation of microtubule-based process|protein localization to microtubule|neutrophil degranulation|ion channel binding|regulation of release of sequestered calcium ion into cytosol|regulation of cytoskeleton organization|cellular response to histamine|mitotic spindle|ficolin-1-rich granule membrane|regulation of cell motility "hsa04510,hsa04810,hsa04933,hsa05131" Focal adhesion|Regulation of actin cytoskeleton|AGE-RAGE signaling pathway in diabetic complications|Shigellosis DIAPH2 703.1477348 583.5996818 822.6957878 1.409691975 0.49537996 0.189448105 1 3.162557786 4.650274898 1730 diaphanous related formin 2 "GO:0003779,GO:0005102,GO:0005730,GO:0005769,GO:0005783,GO:0005829,GO:0007015,GO:0007275,GO:0007292,GO:0043231,GO:0048477" actin binding|signaling receptor binding|nucleolus|early endosome|endoplasmic reticulum|cytosol|actin filament organization|multicellular organism development|female gamete generation|intracellular membrane-bounded organelle|oogenesis hsa04810 Regulation of actin cytoskeleton DIAPH3 1038.240073 792.6806113 1283.799535 1.619567221 0.695608349 0.047488641 0.996379323 3.017851353 5.098151681 81624 diaphanous related formin 3 "GO:0003779,GO:0005634,GO:0005737,GO:0005829,GO:0007010,GO:0030036,GO:0030041,GO:0045296" actin binding|nucleus|cytoplasm|cytosol|cytoskeleton organization|actin cytoskeleton organization|actin filament polymerization|cadherin binding hsa04810 Regulation of actin cytoskeleton DICER1 1127.714059 1049.464471 1205.963646 1.14912289 0.200533091 0.562381304 1 2.889777262 3.463751883 23405 "dicer 1, ribonuclease III" "GO:0000122,GO:0003677,GO:0003723,GO:0003725,GO:0004386,GO:0004521,GO:0004525,GO:0004530,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005793,GO:0005829,GO:0006309,GO:0010586,GO:0010626,GO:0010629,GO:0014040,GO:0016442,GO:0019904,GO:0021675,GO:0030422,GO:0030423,GO:0030425,GO:0030426,GO:0031054,GO:0031643,GO:0032290,GO:0032720,GO:0033167,GO:0033168,GO:0035087,GO:0035148,GO:0035196,GO:0035197,GO:0035280,GO:0036404,GO:0038061,GO:0046872,GO:0048471,GO:0048812,GO:0070062,GO:0070578,GO:0070883,GO:0090501,GO:0090502" "negative regulation of transcription by RNA polymerase II|DNA binding|RNA binding|double-stranded RNA binding|helicase activity|endoribonuclease activity|ribonuclease III activity|deoxyribonuclease I activity|protein binding|ATP binding|nucleus|cytoplasm|endoplasmic reticulum-Golgi intermediate compartment|cytosol|apoptotic DNA fragmentation|miRNA metabolic process|negative regulation of Schwann cell proliferation|negative regulation of gene expression|positive regulation of Schwann cell differentiation|RISC complex|protein domain specific binding|nerve development|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|dendrite|growth cone|pre-miRNA processing|positive regulation of myelination|peripheral nervous system myelin formation|negative regulation of tumor necrosis factor production|ARC complex|conversion of ds siRNA to ss siRNA involved in RNA interference|siRNA loading onto RISC involved in RNA interference|tube formation|production of miRNAs involved in gene silencing by miRNA|siRNA binding|miRNA loading onto RISC involved in gene silencing by miRNA|conversion of ds siRNA to ss siRNA|NIK/NF-kappaB signaling|metal ion binding|perinuclear region of cytoplasm|neuron projection morphogenesis|extracellular exosome|RISC-loading complex|pre-miRNA binding|RNA phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic" hsa05206 MicroRNAs in cancer DIDO1 3851.227151 4130.870791 3571.58351 0.864607898 -0.209882081 0.510050918 1 15.47784514 13.95872094 11083 death inducer-obliterator 1 "GO:0003723,GO:0005634,GO:0005737,GO:0005819,GO:0006351,GO:0046872,GO:0097190" "RNA binding|nucleus|cytoplasm|spindle|transcription, DNA-templated|metal ion binding|apoptotic signaling pathway" DIMT1 417.5858414 392.7879598 442.383723 1.126265997 0.171547597 0.692207921 1 6.214721802 7.300936896 27292 DIMT1 rRNA methyltransferase and ribosome maturation factor "GO:0000179,GO:0003723,GO:0005654,GO:0005730,GO:0005759,GO:0005829,GO:0031167,GO:0052909,GO:2000234" "rRNA (adenine-N6,N6-)-dimethyltransferase activity|RNA binding|nucleoplasm|nucleolus|mitochondrial matrix|cytosol|rRNA methylation|18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity|positive regulation of rRNA processing" DIO2 29.36221581 20.29911937 38.42531225 1.892954642 0.920639843 0.359730447 1 0.153490413 0.303066122 1734 iodothyronine deiodinase 2 "GO:0001514,GO:0004800,GO:0005886,GO:0006590,GO:0008430,GO:0016020,GO:0016021,GO:0031625,GO:0033798,GO:0042403,GO:0042404,GO:0042446,GO:0050873,GO:0055114,GO:0120162" selenocysteine incorporation|thyroxine 5'-deiodinase activity|plasma membrane|thyroid hormone generation|selenium binding|membrane|integral component of membrane|ubiquitin protein ligase binding|thyroxine 5-deiodinase activity|thyroid hormone metabolic process|thyroid hormone catabolic process|hormone biosynthetic process|brown fat cell differentiation|oxidation-reduction process|positive regulation of cold-induced thermogenesis hsa04919 Thyroid hormone signaling pathway DIP2A 1541.850237 1273.76974 1809.930733 1.42092458 0.506829981 0.125399258 1 8.51418025 12.61914112 23181 disco interacting protein 2 homolog A "GO:0003987,GO:0005515,GO:0005634,GO:0005739,GO:0006085,GO:0009986,GO:0010629,GO:0016020,GO:0043197,GO:0060997,GO:2000758" acetate-CoA ligase activity|protein binding|nucleus|mitochondrion|acetyl-CoA biosynthetic process|cell surface|negative regulation of gene expression|membrane|dendritic spine|dendritic spine morphogenesis|positive regulation of peptidyl-lysine acetylation DIP2B 2275.604265 2366.877318 2184.331211 0.922874707 -0.1157933 0.718178841 1 13.77070492 13.25607173 57609 disco interacting protein 2 homolog B "GO:0003674,GO:0005634,GO:0005737,GO:0008150,GO:0016020,GO:0030424,GO:0030425,GO:0030517,GO:0043014,GO:0043204,GO:0070062,GO:2000758" molecular_function|nucleus|cytoplasm|biological_process|membrane|axon|dendrite|negative regulation of axon extension|alpha-tubulin binding|perikaryon|extracellular exosome|positive regulation of peptidyl-lysine acetylation DIP2C 816.7809875 774.4114039 859.1505712 1.109423966 0.149810797 0.684058957 1 3.879446651 4.489347849 22982 disco interacting protein 2 homolog C "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process DIPK1A 398.9346032 464.8498335 333.0193728 0.716402048 -0.481158633 0.267839811 1 7.764843066 5.802370163 388650 divergent protein kinase domain 1A "GO:0005789,GO:0016021" endoplasmic reticulum membrane|integral component of membrane DIPK2A 212.4781366 313.6213942 111.3348791 0.354997717 -1.494118347 0.00542031 0.28256493 3.283815842 1.215962787 205428 divergent protein kinase domain 2A "GO:0000139,GO:0005615,GO:0014066,GO:0030126,GO:0034392,GO:0060038,GO:1900020" Golgi membrane|extracellular space|regulation of phosphatidylinositol 3-kinase signaling|COPI vesicle coat|negative regulation of smooth muscle cell apoptotic process|cardiac muscle cell proliferation|positive regulation of protein kinase C activity DIRAS3 4.537610306 7.104691779 1.970528833 0.277355992 -1.850189203 0.383956367 1 0.242962576 0.07028989 9077 DIRAS family GTPase 3 "GO:0000079,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0006349,GO:0007264,GO:0019003" regulation of cyclin-dependent protein serine/threonine kinase activity|GTPase activity|protein binding|GTP binding|plasma membrane|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction|GDP binding DIS3 1392.722971 1384.399941 1401.046 1.012024025 0.017243539 0.96122793 1 6.59037251 6.956915292 22894 "DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease" "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0003723,GO:0004519,GO:0005085,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0016020,GO:0016075,GO:0043488,GO:0043928,GO:0050790,GO:0071034,GO:0090503" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|RNA binding|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|nucleolus|cytosol|rRNA processing|membrane|rRNA catabolic process|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|regulation of catalytic activity|CUT catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation DIS3L 435.8726162 396.8477836 474.8974488 1.196674061 0.259030258 0.54259991 1 3.540415756 4.419224574 115752 DIS3 like exosome 3'-5' exoribonuclease "GO:0000175,GO:0000177,GO:0000178,GO:0003723,GO:0005515,GO:0005813,GO:0005829,GO:0005886,GO:0016075,GO:0019899,GO:0090503" "3'-5'-exoribonuclease activity|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|RNA binding|protein binding|centrosome|cytosol|plasma membrane|rRNA catabolic process|enzyme binding|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation DIS3L2 431.661613 412.0721232 451.2511028 1.095077967 0.13103359 0.761546895 1 4.597928913 5.251981929 129563 DIS3 like 3'-5' exoribonuclease 2 "GO:0000175,GO:0000178,GO:0000278,GO:0000287,GO:0000291,GO:0000932,GO:0004540,GO:0005515,GO:0005737,GO:0005844,GO:0006402,GO:0008266,GO:0008285,GO:0010587,GO:0019827,GO:0034427,GO:0051301,GO:0051306,GO:0090503,GO:1990074" "3'-5'-exoribonuclease activity|exosome (RNase complex)|mitotic cell cycle|magnesium ion binding|nuclear-transcribed mRNA catabolic process, exonucleolytic|P-body|ribonuclease activity|protein binding|cytoplasm|polysome|mRNA catabolic process|poly(U) RNA binding|negative regulation of cell population proliferation|miRNA catabolic process|stem cell population maintenance|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|cell division|mitotic sister chromatid separation|RNA phosphodiester bond hydrolysis, exonucleolytic|polyuridylation-dependent mRNA catabolic process" DISC1 197.876082 157.3181751 238.4339888 1.515616289 0.599904551 0.268070316 1 0.593313767 0.937971451 27185 DISC1 scaffold protein "GO:0000226,GO:0001764,GO:0001954,GO:0002052,GO:0005515,GO:0005634,GO:0005739,GO:0005783,GO:0005813,GO:0005829,GO:0005871,GO:0005874,GO:0008021,GO:0010975,GO:0010976,GO:0014069,GO:0019894,GO:0021846,GO:0021852,GO:0030177,GO:0030286,GO:0031929,GO:0032091,GO:0036064,GO:0044297,GO:0044877,GO:0045111,GO:0045773,GO:0048471,GO:0051560,GO:0051602,GO:0051966,GO:0060070,GO:0060090,GO:0060271,GO:0060998,GO:0071539,GO:0090128,GO:0090724,GO:0097546,GO:1905515,GO:2000060" "microtubule cytoskeleton organization|neuron migration|positive regulation of cell-matrix adhesion|positive regulation of neuroblast proliferation|protein binding|nucleus|mitochondrion|endoplasmic reticulum|centrosome|cytosol|kinesin complex|microtubule|synaptic vesicle|regulation of neuron projection development|positive regulation of neuron projection development|postsynaptic density|kinesin binding|cell proliferation in forebrain|pyramidal neuron migration|positive regulation of Wnt signaling pathway|dynein complex|TOR signaling|negative regulation of protein binding|ciliary basal body|cell body|protein-containing complex binding|intermediate filament cytoskeleton|positive regulation of axon extension|perinuclear region of cytoplasm|mitochondrial calcium ion homeostasis|response to electrical stimulus|regulation of synaptic transmission, glutamatergic|canonical Wnt signaling pathway|molecular adaptor activity|cilium assembly|regulation of dendritic spine development|protein localization to centrosome|regulation of synapse maturation|central region of growth cone|ciliary base|non-motile cilium assembly|positive regulation of ubiquitin-dependent protein catabolic process" DISP1 97.65177864 108.6002886 86.70326866 0.798370518 -0.324869649 0.642026644 1 0.771095121 0.642138007 84976 dispatched RND transporter family member 1 "GO:0005515,GO:0015833,GO:0016021,GO:0016323,GO:0050708,GO:0060539,GO:0070207,GO:0098656,GO:1904680" protein binding|peptide transport|integral component of membrane|basolateral plasma membrane|regulation of protein secretion|diaphragm development|protein homotrimerization|anion transmembrane transport|peptide transmembrane transporter activity DISP2 107.8013383 128.899408 86.70326866 0.672642877 -0.572087349 0.388996732 1 0.442087105 0.310176096 85455 dispatched RND transporter family member 2 "GO:0003674,GO:0005575,GO:0005886,GO:0007224,GO:0016021" molecular_function|cellular_component|plasma membrane|smoothened signaling pathway|integral component of membrane DIXDC1 509.7471585 462.8199216 556.6743953 1.202788319 0.266382762 0.513842458 1 3.295402263 4.134410234 85458 DIX domain containing 1 "GO:0003779,GO:0005515,GO:0005829,GO:0005856,GO:0005925,GO:0019904,GO:0021799,GO:0021869,GO:0030177,GO:0032956,GO:0043015,GO:0045665,GO:0060070,GO:0070507" actin binding|protein binding|cytosol|cytoskeleton|focal adhesion|protein domain specific binding|cerebral cortex radially oriented cell migration|forebrain ventricular zone progenitor cell division|positive regulation of Wnt signaling pathway|regulation of actin cytoskeleton organization|gamma-tubulin binding|negative regulation of neuron differentiation|canonical Wnt signaling pathway|regulation of microtubule cytoskeleton organization DKC1 2035.466971 2385.146526 1685.787417 0.706785683 -0.500655278 0.120202588 1 49.2254512 36.2905357 1736 dyskerin pseudouridine synthase 1 "GO:0000455,GO:0000495,GO:0001650,GO:0003720,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005697,GO:0005730,GO:0005737,GO:0006364,GO:0006396,GO:0007004,GO:0009982,GO:0031118,GO:0031120,GO:0031429,GO:0032212,GO:0034513,GO:0051973,GO:0070034,GO:0072589,GO:0090661,GO:0090666,GO:0090669,GO:1904851,GO:1904871,GO:1904872,GO:1904874,GO:1990481" enzyme-directed rRNA pseudouridine synthesis|box H/ACA RNA 3'-end processing|fibrillar center|telomerase activity|RNA binding|protein binding|nucleus|nucleoplasm|telomerase holoenzyme complex|nucleolus|cytoplasm|rRNA processing|RNA processing|telomere maintenance via telomerase|pseudouridine synthase activity|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis|box H/ACA snoRNP complex|positive regulation of telomere maintenance via telomerase|box H/ACA snoRNA binding|positive regulation of telomerase activity|telomerase RNA binding|box H/ACA scaRNP complex|box H/ACA telomerase RNP complex|scaRNA localization to Cajal body|telomerase RNA stabilization|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|regulation of telomerase RNA localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body|mRNA pseudouridine synthesis hsa03008 Ribosome biogenesis in eukaryotes DKK1 375.8726856 437.4460224 314.2993489 0.718487157 -0.476965727 0.280320725 1 12.27429242 9.198804832 22943 dickkopf WNT signaling pathway inhibitor 1 "GO:0000122,GO:0002090,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007611,GO:0008083,GO:0010628,GO:0010942,GO:0016055,GO:0030178,GO:0030279,GO:0031901,GO:0032091,GO:0033137,GO:0039706,GO:0042662,GO:0042663,GO:0043066,GO:0043507,GO:0045813,GO:0048019,GO:0050750,GO:0060173,GO:0060394,GO:0090082,GO:0090090,GO:0090647,GO:0098883,GO:1901216,GO:1901296,GO:1902949,GO:1904338,GO:1904723,GO:2000096,GO:2000272,GO:2000726" "negative regulation of transcription by RNA polymerase II|regulation of receptor internalization|protein binding|extracellular region|extracellular space|plasma membrane|learning or memory|growth factor activity|positive regulation of gene expression|positive regulation of cell death|Wnt signaling pathway|negative regulation of Wnt signaling pathway|negative regulation of ossification|early endosome membrane|negative regulation of protein binding|negative regulation of peptidyl-serine phosphorylation|co-receptor binding|negative regulation of mesodermal cell fate specification|regulation of endodermal cell fate specification|negative regulation of apoptotic process|positive regulation of JUN kinase activity|positive regulation of Wnt signaling pathway, calcium modulating pathway|receptor antagonist activity|low-density lipoprotein particle receptor binding|limb development|negative regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|modulation of age-related behavioral decline|synapse pruning|positive regulation of neuron death|negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|positive regulation of tau-protein kinase activity|regulation of dopaminergic neuron differentiation|negative regulation of Wnt-Frizzled-LRP5/6 complex assembly|positive regulation of Wnt signaling pathway, planar cell polarity pathway|negative regulation of signaling receptor activity|negative regulation of cardiac muscle cell differentiation" "hsa04310,hsa05010,hsa05022" Wnt signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases DKK3 9503.572094 9612.647976 9394.496212 0.977305757 -0.033118104 0.921535774 1 146.508188 149.3510513 27122 dickkopf WNT signaling pathway inhibitor 3 "GO:0005515,GO:0005615,GO:0009653,GO:0016055,GO:0017015,GO:0030325,GO:0032348,GO:0039706,GO:0045892,GO:0048019,GO:0090090,GO:1902613,GO:2000065,GO:2000272" "protein binding|extracellular space|anatomical structure morphogenesis|Wnt signaling pathway|regulation of transforming growth factor beta receptor signaling pathway|adrenal gland development|negative regulation of aldosterone biosynthetic process|co-receptor binding|negative regulation of transcription, DNA-templated|receptor antagonist activity|negative regulation of canonical Wnt signaling pathway|negative regulation of anti-Mullerian hormone signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of signaling receptor activity" DLAT 1645.383664 1750.799045 1539.968283 0.879580262 -0.185112865 0.573059172 1 23.52661056 21.58493616 1737 dihydrolipoamide S-acetyltransferase "GO:0004742,GO:0005515,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006086,GO:0006090,GO:0006099,GO:0018215,GO:0030431,GO:0034604,GO:0042802,GO:0043231,GO:0045254" dihydrolipoyllysine-residue acetyltransferase activity|protein binding|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|acetyl-CoA biosynthetic process from pyruvate|pyruvate metabolic process|tricarboxylic acid cycle|protein phosphopantetheinylation|sleep|pyruvate dehydrogenase (NAD+) activity|identical protein binding|intracellular membrane-bounded organelle|pyruvate dehydrogenase complex "hsa00010,hsa00020,hsa00620" Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism DLC1 2576.479819 2223.768527 2929.19111 1.31721943 0.397495698 0.212756105 1 12.2981034 16.89710092 10395 DLC1 Rho GTPase activating protein "GO:0001843,GO:0003007,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005901,GO:0005925,GO:0006915,GO:0006919,GO:0007165,GO:0008285,GO:0008289,GO:0008360,GO:0021575,GO:0030036,GO:0030336,GO:0030864,GO:0030900,GO:0032587,GO:0032956,GO:0035023,GO:0035024,GO:0035307,GO:0042169,GO:0043547,GO:0045121,GO:0048041,GO:0051056,GO:0051497,GO:0051895,GO:1900119" neural tube closure|heart morphogenesis|GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|caveola|focal adhesion|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|negative regulation of cell population proliferation|lipid binding|regulation of cell shape|hindbrain morphogenesis|actin cytoskeleton organization|negative regulation of cell migration|cortical actin cytoskeleton|forebrain development|ruffle membrane|regulation of actin cytoskeleton organization|regulation of Rho protein signal transduction|negative regulation of Rho protein signal transduction|positive regulation of protein dephosphorylation|SH2 domain binding|positive regulation of GTPase activity|membrane raft|focal adhesion assembly|regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly|positive regulation of execution phase of apoptosis DLD 1743.128477 2000.478214 1485.77874 0.742711783 -0.429125629 0.188289426 1 28.04239254 21.72457594 1738 dihydrolipoamide dehydrogenase "GO:0004148,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0006090,GO:0006099,GO:0006103,GO:0006120,GO:0006508,GO:0006554,GO:0007369,GO:0007568,GO:0009083,GO:0009106,GO:0031514,GO:0034604,GO:0042391,GO:0043159,GO:0043544,GO:0045252,GO:0045254,GO:0045454,GO:0048240,GO:0050660,GO:0051068,GO:0051287,GO:0055114,GO:0061732,GO:0106077" "dihydrolipoyl dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial matrix|pyruvate metabolic process|tricarboxylic acid cycle|2-oxoglutarate metabolic process|mitochondrial electron transport, NADH to ubiquinone|proteolysis|lysine catabolic process|gastrulation|aging|branched-chain amino acid catabolic process|lipoate metabolic process|motile cilium|pyruvate dehydrogenase (NAD+) activity|regulation of membrane potential|acrosomal matrix|lipoamide binding|oxoglutarate dehydrogenase complex|pyruvate dehydrogenase complex|cell redox homeostasis|sperm capacitation|flavin adenine dinucleotide binding|dihydrolipoamide metabolic process|NAD binding|oxidation-reduction process|mitochondrial acetyl-CoA biosynthetic process from pyruvate|histone succinylation" "hsa00010,hsa00020,hsa00260,hsa00280,hsa00310,hsa00380,hsa00620,hsa00630,hsa00640" "Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Glycine, serine and threonine metabolism|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism" DLEC1 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.020401087 0.013771574 9940 DLEC1 cilia and flagella associated protein "GO:0003674,GO:0005737,GO:0005829,GO:0008285" molecular_function|cytoplasm|cytosol|negative regulation of cell population proliferation DLG1 2113.308303 2318.159432 1908.457175 0.823263986 -0.280572978 0.382397154 1 13.00471835 11.16750095 1739 discs large MAGUK scaffold protein 1 "GO:0000122,GO:0000165,GO:0001658,GO:0001771,GO:0001772,GO:0001935,GO:0002088,GO:0004385,GO:0004721,GO:0005515,GO:0005604,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005874,GO:0005886,GO:0005911,GO:0005923,GO:0006470,GO:0007015,GO:0007163,GO:0007268,GO:0008022,GO:0008092,GO:0008284,GO:0008328,GO:0008360,GO:0009790,GO:0009898,GO:0014704,GO:0015459,GO:0016032,GO:0016323,GO:0016324,GO:0016328,GO:0019901,GO:0019902,GO:0030054,GO:0030432,GO:0030838,GO:0030866,GO:0030953,GO:0031253,GO:0031434,GO:0031579,GO:0031594,GO:0031641,GO:0032147,GO:0033268,GO:0034629,GO:0035748,GO:0042110,GO:0042130,GO:0042383,GO:0042391,GO:0042982,GO:0043005,GO:0043113,GO:0043219,GO:0043268,GO:0043622,GO:0044325,GO:0045121,GO:0045197,GO:0045296,GO:0046037,GO:0046710,GO:0048471,GO:0048608,GO:0048704,GO:0048745,GO:0050680,GO:0051660,GO:0051898,GO:0060022,GO:0060090,GO:0070062,GO:0070373,GO:0070830,GO:0072659,GO:0097016,GO:0097025,GO:0097060,GO:0097120,GO:0098609,GO:0098839,GO:0098911,GO:0098919,GO:0098978,GO:0099562,GO:0099645,GO:1901222,GO:1902305,GO:1902473,GO:1903078,GO:1903286,GO:1903753,GO:1903760,GO:1903764,GO:2000134,GO:2000310" negative regulation of transcription by RNA polymerase II|MAPK cascade|branching involved in ureteric bud morphogenesis|immunological synapse formation|immunological synapse|endothelial cell proliferation|lens development in camera-type eye|guanylate kinase activity|phosphoprotein phosphatase activity|protein binding|basement membrane|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|microtubule|plasma membrane|cell-cell junction|bicellular tight junction|protein dephosphorylation|actin filament organization|establishment or maintenance of cell polarity|chemical synaptic transmission|protein C-terminus binding|cytoskeletal protein binding|positive regulation of cell population proliferation|ionotropic glutamate receptor complex|regulation of cell shape|embryo development|cytoplasmic side of plasma membrane|intercalated disc|potassium channel regulator activity|viral process|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|protein kinase binding|phosphatase binding|cell junction|peristalsis|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|astral microtubule organization|cell projection membrane|mitogen-activated protein kinase kinase binding|membrane raft organization|neuromuscular junction|regulation of myelination|activation of protein kinase activity|node of Ranvier|cellular protein-containing complex localization|myelin sheath abaxonal region|T cell activation|negative regulation of T cell proliferation|sarcolemma|regulation of membrane potential|amyloid precursor protein metabolic process|neuron projection|receptor clustering|lateral loop|positive regulation of potassium ion transport|cortical microtubule organization|ion channel binding|membrane raft|establishment or maintenance of epithelial cell apical/basal polarity|cadherin binding|GMP metabolic process|GDP metabolic process|perinuclear region of cytoplasm|reproductive structure development|embryonic skeletal system morphogenesis|smooth muscle tissue development|negative regulation of epithelial cell proliferation|establishment of centrosome localization|negative regulation of protein kinase B signaling|hard palate development|molecular adaptor activity|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|bicellular tight junction assembly|protein localization to plasma membrane|L27 domain binding|MPP7-DLG1-LIN7 complex|synaptic membrane|receptor localization to synapse|cell-cell adhesion|postsynaptic density membrane|regulation of ventricular cardiac muscle cell action potential|structural constituent of postsynaptic density|glutamatergic synapse|maintenance of postsynaptic density structure|neurotransmitter receptor localization to postsynaptic specialization membrane|regulation of NIK/NF-kappaB signaling|regulation of sodium ion transmembrane transport|regulation of protein localization to synapse|positive regulation of protein localization to plasma membrane|regulation of potassium ion import|negative regulation of p38MAPK cascade|regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|regulation of potassium ion export across plasma membrane|negative regulation of G1/S transition of mitotic cell cycle|regulation of NMDA receptor activity "hsa04390,hsa04530,hsa04660,hsa05165,hsa05166,hsa05203" Hippo signaling pathway|Tight junction|T cell receptor signaling pathway|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis DLG2 36.55598224 40.59823873 32.51372575 0.800865426 -0.320368257 0.751518299 1 0.107787669 0.09004188 1740 discs large MAGUK scaffold protein 2 "GO:0000165,GO:0004385,GO:0005515,GO:0005829,GO:0005886,GO:0007268,GO:0008076,GO:0008328,GO:0009790,GO:0010923,GO:0014069,GO:0016020,GO:0016323,GO:0019900,GO:0030054,GO:0031594,GO:0035865,GO:0043005,GO:0043113,GO:0043204,GO:0044224,GO:0045197,GO:0046037,GO:0046710,GO:0097120,GO:0098609,GO:0098839,GO:0099641,GO:0099642,GO:1904115,GO:2000310" MAPK cascade|guanylate kinase activity|protein binding|cytosol|plasma membrane|chemical synaptic transmission|voltage-gated potassium channel complex|ionotropic glutamate receptor complex|embryo development|negative regulation of phosphatase activity|postsynaptic density|membrane|basolateral plasma membrane|kinase binding|cell junction|neuromuscular junction|cellular response to potassium ion|neuron projection|receptor clustering|perikaryon|juxtaparanode region of axon|establishment or maintenance of epithelial cell apical/basal polarity|GMP metabolic process|GDP metabolic process|receptor localization to synapse|cell-cell adhesion|postsynaptic density membrane|anterograde axonal protein transport|retrograde axonal protein transport|axon cytoplasm|regulation of NMDA receptor activity "hsa04390,hsa04530,hsa05165" Hippo signaling pathway|Tight junction|Human papillomavirus infection DLG3 1206.466426 977.4025975 1435.530255 1.468719501 0.554558893 0.105052749 1 5.544578125 8.494215952 1741 discs large MAGUK scaffold protein 3 "GO:0000165,GO:0005515,GO:0005615,GO:0005829,GO:0005886,GO:0008285,GO:0008328,GO:0009790,GO:0010923,GO:0016323,GO:0019900,GO:0019902,GO:0030054,GO:0043113,GO:0045197,GO:0061098,GO:0097120,GO:0098609,GO:2000310" MAPK cascade|protein binding|extracellular space|cytosol|plasma membrane|negative regulation of cell population proliferation|ionotropic glutamate receptor complex|embryo development|negative regulation of phosphatase activity|basolateral plasma membrane|kinase binding|phosphatase binding|cell junction|receptor clustering|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of protein tyrosine kinase activity|receptor localization to synapse|cell-cell adhesion|regulation of NMDA receptor activity "hsa04390,hsa04530,hsa05165" Hippo signaling pathway|Tight junction|Human papillomavirus infection DLG4 1199.755889 889.1014283 1510.410351 1.698805448 0.764520641 0.025931747 0.715842983 6.193927205 10.97553431 1742 discs large MAGUK scaffold protein 4 "GO:0000165,GO:0002091,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0007165,GO:0007204,GO:0007268,GO:0007399,GO:0007612,GO:0008021,GO:0008022,GO:0008076,GO:0008328,GO:0014069,GO:0016188,GO:0019900,GO:0019903,GO:0030054,GO:0030165,GO:0030666,GO:0030863,GO:0031234,GO:0031594,GO:0031697,GO:0031748,GO:0031812,GO:0032281,GO:0032839,GO:0033130,GO:0035176,GO:0035255,GO:0035418,GO:0035641,GO:0035865,GO:0043005,GO:0043113,GO:0043197,GO:0044224,GO:0044300,GO:0044306,GO:0044309,GO:0044877,GO:0045184,GO:0045202,GO:0045211,GO:0048169,GO:0050806,GO:0050885,GO:0060076,GO:0060997,GO:0061098,GO:0065003,GO:0071625,GO:0097060,GO:0097109,GO:0097110,GO:0097113,GO:0097120,GO:0098609,GO:0098839,GO:0098970,GO:0098978,GO:0150012,GO:2000310,GO:2000463,GO:2000821" MAPK cascade|negative regulation of receptor internalization|protein binding|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|signal transduction|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|nervous system development|learning|synaptic vesicle|protein C-terminus binding|voltage-gated potassium channel complex|ionotropic glutamate receptor complex|postsynaptic density|synaptic vesicle maturation|kinase binding|protein phosphatase binding|cell junction|PDZ domain binding|endocytic vesicle membrane|cortical cytoskeleton|extrinsic component of cytoplasmic side of plasma membrane|neuromuscular junction|beta-1 adrenergic receptor binding|D1 dopamine receptor binding|P2Y1 nucleotide receptor binding|AMPA glutamate receptor complex|dendrite cytoplasm|acetylcholine receptor binding|social behavior|ionotropic glutamate receptor binding|protein localization to synapse|locomotory exploration behavior|cellular response to potassium ion|neuron projection|receptor clustering|dendritic spine|juxtaparanode region of axon|cerebellar mossy fiber|neuron projection terminus|neuron spine|protein-containing complex binding|establishment of protein localization|synapse|postsynaptic membrane|regulation of long-term neuronal synaptic plasticity|positive regulation of synaptic transmission|neuromuscular process controlling balance|excitatory synapse|dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|protein-containing complex assembly|vocalization behavior|synaptic membrane|neuroligin family protein binding|scaffold protein binding|AMPA glutamate receptor clustering|receptor localization to synapse|cell-cell adhesion|postsynaptic density membrane|postsynaptic neurotransmitter receptor diffusion trapping|glutamatergic synapse|positive regulation of neuron projection arborization|regulation of NMDA receptor activity|positive regulation of excitatory postsynaptic potential|regulation of grooming behavior "hsa04390,hsa04724,hsa05016,hsa05022,hsa05030" Hippo signaling pathway|Glutamatergic synapse|Huntington disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction DLG5 4782.645953 4491.18016 5074.111745 1.129794745 0.176060696 0.582911912 1 22.44990438 26.45635295 9231 discs large MAGUK scaffold protein 5 "GO:0001837,GO:0005515,GO:0005737,GO:0005886,GO:0005912,GO:0007165,GO:0008013,GO:0008092,GO:0008285,GO:0014069,GO:0030011,GO:0030054,GO:0030159,GO:0030336,GO:0030859,GO:0030901,GO:0035331,GO:0035332,GO:0035556,GO:0036064,GO:0042130,GO:0042981,GO:0045176,GO:0045186,GO:0045197,GO:0045880,GO:0051965,GO:0060441,GO:0060999,GO:0065003,GO:0071896,GO:0072205,GO:0098609" epithelial to mesenchymal transition|protein binding|cytoplasm|plasma membrane|adherens junction|signal transduction|beta-catenin binding|cytoskeletal protein binding|negative regulation of cell population proliferation|postsynaptic density|maintenance of cell polarity|cell junction|signaling receptor complex adaptor activity|negative regulation of cell migration|polarized epithelial cell differentiation|midbrain development|negative regulation of hippo signaling|positive regulation of hippo signaling|intracellular signal transduction|ciliary basal body|negative regulation of T cell proliferation|regulation of apoptotic process|apical protein localization|zonula adherens assembly|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of smoothened signaling pathway|positive regulation of synapse assembly|epithelial tube branching involved in lung morphogenesis|positive regulation of dendritic spine development|protein-containing complex assembly|protein localization to adherens junction|metanephric collecting duct development|cell-cell adhesion hsa04390 Hippo signaling pathway DLGAP4 2020.120152 1841.130127 2199.110178 1.194434954 0.25632829 0.426250185 1 15.03252391 18.7288166 22839 DLG associated protein 4 "GO:0005515,GO:0005886,GO:0023052,GO:0031594,GO:0060090,GO:0098962,GO:0098978,GO:0098981,GO:0099572" protein binding|plasma membrane|signaling|neuromuscular junction|molecular adaptor activity|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse|cholinergic synapse|postsynaptic specialization DLGAP5 1536.607948 1487.92545 1585.290446 1.065436744 0.091444941 0.783467484 1 22.98907106 25.5484774 9787 DLG associated protein 5 "GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0007052,GO:0007059,GO:0007079,GO:0007221,GO:0007346,GO:0008017,GO:0031616,GO:0034451,GO:0045842,GO:0051382,GO:0051642" protein binding|nucleus|cytoplasm|mitochondrion|cytosol|mitotic spindle organization|chromosome segregation|mitotic chromosome movement towards spindle pole|positive regulation of transcription of Notch receptor target|regulation of mitotic cell cycle|microtubule binding|spindle pole centrosome|centriolar satellite|positive regulation of mitotic metaphase/anaphase transition|kinetochore assembly|centrosome localization DLK2 144.4639626 143.1087915 145.8191336 1.018939033 0.027067732 0.976848531 1 2.771684678 2.945831827 65989 delta like non-canonical Notch ligand 2 "GO:0005112,GO:0005509,GO:0016021,GO:0045598,GO:0045746" Notch binding|calcium ion binding|integral component of membrane|regulation of fat cell differentiation|negative regulation of Notch signaling pathway DLL1 30.46624643 28.41876711 32.51372575 1.144093465 0.194204916 0.874368142 1 0.380266922 0.453801559 28514 delta like canonical Notch ligand 1 "GO:0001709,GO:0001756,GO:0001757,GO:0001947,GO:0002315,GO:0003323,GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0005912,GO:0007219,GO:0007368,GO:0007386,GO:0008217,GO:0008284,GO:0008285,GO:0009954,GO:0014002,GO:0014807,GO:0016324,GO:0021510,GO:0021688,GO:0021693,GO:0030097,GO:0030154,GO:0030155,GO:0030857,GO:0030957,GO:0031410,GO:0032693,GO:0034351,GO:0035265,GO:0040008,GO:0045121,GO:0045596,GO:0045605,GO:0045608,GO:0045638,GO:0045662,GO:0045665,GO:0045746,GO:0045747,GO:0045807,GO:0045944,GO:0046331,GO:0048630,GO:0048631,GO:0048633,GO:0048665,GO:0048839,GO:0050767,GO:0051302,GO:0060041,GO:0060042,GO:0060853,GO:0070986,GO:0072006,GO:0072014,GO:0072070,GO:0072583,GO:0097009,GO:0097102,GO:0097110,GO:0097150,GO:0098773,GO:1900746,GO:1903672,GO:2000726" cell fate determination|somitogenesis|somite specification|heart looping|marginal zone B cell differentiation|type B pancreatic cell development|Notch binding|calcium ion binding|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|adherens junction|Notch signaling pathway|determination of left/right symmetry|compartment pattern specification|regulation of blood pressure|positive regulation of cell population proliferation|negative regulation of cell population proliferation|proximal/distal pattern formation|astrocyte development|regulation of somitogenesis|apical plasma membrane|spinal cord development|cerebellar molecular layer formation|cerebellar Purkinje cell layer structural organization|hemopoiesis|cell differentiation|regulation of cell adhesion|negative regulation of epithelial cell differentiation|Tat protein binding|cytoplasmic vesicle|negative regulation of interleukin-10 production|negative regulation of glial cell apoptotic process|organ growth|regulation of growth|membrane raft|negative regulation of cell differentiation|negative regulation of epidermal cell differentiation|negative regulation of inner ear auditory receptor cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of myoblast differentiation|negative regulation of neuron differentiation|negative regulation of Notch signaling pathway|positive regulation of Notch signaling pathway|positive regulation of endocytosis|positive regulation of transcription by RNA polymerase II|lateral inhibition|skeletal muscle tissue growth|regulation of skeletal muscle tissue growth|positive regulation of skeletal muscle tissue growth|neuron fate specification|inner ear development|regulation of neurogenesis|regulation of cell division|retina development in camera-type eye|retina morphogenesis in camera-type eye|Notch signaling pathway involved in arterial endothelial cell fate commitment|left/right axis specification|nephron development|proximal tubule development|loop of Henle development|clathrin-dependent endocytosis|energy homeostasis|endothelial tip cell fate specification|scaffold protein binding|neuronal stem cell population maintenance|skin epidermis development|regulation of vascular endothelial growth factor signaling pathway|positive regulation of sprouting angiogenesis|negative regulation of cardiac muscle cell differentiation "hsa01522,hsa04330,hsa04658,hsa05200,hsa05224" Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Pathways in cancer|Breast cancer DLST 3793.319483 3775.636202 3811.002763 1.009367047 0.013450892 0.967195091 1 51.6259865 54.35423845 1743 dihydrolipoamide S-succinyltransferase "GO:0004149,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006091,GO:0006099,GO:0006103,GO:0006104,GO:0006554,GO:0016020,GO:0016746,GO:0018215,GO:0033512,GO:0034451,GO:0045252,GO:0106077" "dihydrolipoyllysine-residue succinyltransferase activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|generation of precursor metabolites and energy|tricarboxylic acid cycle|2-oxoglutarate metabolic process|succinyl-CoA metabolic process|lysine catabolic process|membrane|transferase activity, transferring acyl groups|protein phosphopantetheinylation|L-lysine catabolic process to acetyl-CoA via saccharopine|centriolar satellite|oxoglutarate dehydrogenase complex|histone succinylation" "hsa00020,hsa00310,hsa00380" Citrate cycle (TCA cycle)|Lysine degradation|Tryptophan metabolism DLX1 365.2008022 415.1169911 315.2846133 0.75950785 -0.396863219 0.37351088 1 8.923688944 7.069563831 1745 distal-less homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003682,GO:0005515,GO:0005634,GO:0006357,GO:0009790,GO:0009954,GO:0021544,GO:0021766,GO:0021879,GO:0021893,GO:0030154,GO:0030514,GO:0042475,GO:0043524,GO:0045597,GO:0045746,GO:0045944,GO:0046533,GO:0048706,GO:0048715,GO:0071560,GO:0071773,GO:1902871,GO:1903845,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|chromatin binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|embryo development|proximal/distal pattern formation|subpallium development|hippocampus development|forebrain neuron differentiation|cerebral cortex GABAergic interneuron fate commitment|cell differentiation|negative regulation of BMP signaling pathway|odontogenesis of dentin-containing tooth|negative regulation of neuron apoptotic process|positive regulation of cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|negative regulation of photoreceptor cell differentiation|embryonic skeletal system development|negative regulation of oligodendrocyte differentiation|cellular response to transforming growth factor beta stimulus|cellular response to BMP stimulus|positive regulation of amacrine cell differentiation|negative regulation of cellular response to transforming growth factor beta stimulus|sequence-specific double-stranded DNA binding" DLX2 24.59919726 31.46363502 17.7347595 0.563658951 -0.82710559 0.438078399 1 0.649357016 0.381782374 1746 distal-less homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003682,GO:0003700,GO:0003727,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0009790,GO:0009954,GO:0021544,GO:0021766,GO:0021772,GO:0021879,GO:0021893,GO:0030154,GO:0042475,GO:0045597,GO:0045746,GO:0045944,GO:0046533,GO:0048701,GO:0048715,GO:0048755,GO:0051216,GO:1902871,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|single-stranded RNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|embryo development|proximal/distal pattern formation|subpallium development|hippocampus development|olfactory bulb development|forebrain neuron differentiation|cerebral cortex GABAergic interneuron fate commitment|cell differentiation|odontogenesis of dentin-containing tooth|positive regulation of cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|negative regulation of photoreceptor cell differentiation|embryonic cranial skeleton morphogenesis|negative regulation of oligodendrocyte differentiation|branching morphogenesis of a nerve|cartilage development|positive regulation of amacrine cell differentiation|sequence-specific double-stranded DNA binding" Homeobox DLX4 38.52651107 40.59823873 36.45478341 0.897940023 -0.155309011 0.892691791 1 0.828761616 0.776234404 1748 distal-less homeobox 4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0007275,GO:0009790,GO:0030154,GO:0043565,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|embryo development|cell differentiation|sequence-specific DNA binding|sequence-specific double-stranded DNA binding" Homeobox DMAC1 488.4546099 522.7023237 454.206896 0.868959014 -0.202639963 0.624340014 1 10.72651082 9.722404769 90871 distal membrane arm assembly component 1 "GO:0005743,GO:0005747,GO:0016021,GO:0032981" mitochondrial inner membrane|mitochondrial respiratory chain complex I|integral component of membrane|mitochondrial respiratory chain complex I assembly DMAC2 850.2030272 802.830171 897.5758835 1.118014639 0.160939078 0.659170149 1 21.72036108 25.32972417 55101 distal membrane arm assembly component 2 "GO:0005747,GO:0019005,GO:0031146,GO:0032981" mitochondrial respiratory chain complex I|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrial respiratory chain complex I assembly DMAC2L 205.8297046 195.8865019 215.7729072 1.101520039 0.139495741 0.801184513 1 1.387935125 1.594694509 27109 distal membrane arm assembly component 2 like "GO:0005743,GO:0006754,GO:0015078,GO:0042407,GO:0042776,GO:0045263,GO:0046872,GO:1902600" "mitochondrial inner membrane|ATP biosynthetic process|proton transmembrane transporter activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|metal ion binding|proton transmembrane transport" DMAP1 813.5849403 791.6656553 835.5042252 1.055375106 0.07775586 0.834654394 1 25.68550456 28.275538 55929 DNA methyltransferase 1 associated protein 1 "GO:0000122,GO:0000812,GO:0001103,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005829,GO:0006281,GO:0006306,GO:0035267,GO:0040008,GO:0042307,GO:0043486,GO:0043967,GO:0043968,GO:0045471,GO:0045892" "negative regulation of transcription by RNA polymerase II|Swr1 complex|RNA polymerase II repressing transcription factor binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|replication fork|cytoplasm|cytosol|DNA repair|DNA methylation|NuA4 histone acetyltransferase complex|regulation of growth|positive regulation of protein import into nucleus|histone exchange|histone H4 acetylation|histone H2A acetylation|response to ethanol|negative regulation of transcription, DNA-templated" DMBX1 92.1491929 35.52345889 148.7749269 4.188075473 2.066287441 0.004243166 0.24063543 0.565055865 2.468435685 127343 diencephalon/mesencephalon homeobox 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005634,GO:0005667,GO:0006357,GO:0007417,GO:0007420,GO:0008343,GO:0008344,GO:0042802,GO:0043565,GO:0045892,GO:0048589,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|central nervous system development|brain development|adult feeding behavior|adult locomotory behavior|identical protein binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|developmental growth|sequence-specific double-stranded DNA binding" DMC1 5.508028946 6.08973581 4.926322083 0.808954975 -0.305868687 0.976518791 1 0.116518185 0.098318216 11144 DNA meiotic recombinase 1 "GO:0000150,GO:0000730,GO:0000781,GO:0000794,GO:0001541,GO:0001556,GO:0003677,GO:0003690,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0006312,GO:0007129,GO:0007131,GO:0007141,GO:0007283,GO:0007286,GO:0007292,GO:0008094,GO:0010212,GO:0042148,GO:0042802,GO:0051321,GO:0070192" "recombinase activity|DNA recombinase assembly|chromosome, telomeric region|condensed nuclear chromosome|ovarian follicle development|oocyte maturation|DNA binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|chromosome|mitotic recombination|homologous chromosome pairing at meiosis|reciprocal meiotic recombination|male meiosis I|spermatogenesis|spermatid development|female gamete generation|DNA-dependent ATPase activity|response to ionizing radiation|strand invasion|identical protein binding|meiotic cell cycle|chromosome organization involved in meiotic cell cycle" DMD 292.5963157 334.9354696 250.2571618 0.747180232 -0.420471809 0.378614717 1 0.717173295 0.558940286 1756 dystrophin "GO:0002027,GO:0002162,GO:0003779,GO:0005200,GO:0005515,GO:0005829,GO:0005856,GO:0007010,GO:0007517,GO:0008270,GO:0008307,GO:0009986,GO:0010880,GO:0010881,GO:0014809,GO:0014819,GO:0016010,GO:0016013,GO:0016328,GO:0017022,GO:0017166,GO:0030018,GO:0030049,GO:0030055,GO:0030175,GO:0031527,GO:0032991,GO:0033137,GO:0034613,GO:0034622,GO:0035633,GO:0035994,GO:0042383,GO:0043034,GO:0043043,GO:0044306,GO:0045121,GO:0045202,GO:0045211,GO:0046716,GO:0048747,GO:0050998,GO:0060048,GO:0060314,GO:0086001,GO:1901385,GO:1902083,GO:2000651" regulation of heart rate|dystroglycan binding|actin binding|structural constituent of cytoskeleton|protein binding|cytosol|cytoskeleton|cytoskeleton organization|muscle organ development|zinc ion binding|structural constituent of muscle|cell surface|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|regulation of skeletal muscle contraction|dystrophin-associated glycoprotein complex|syntrophin complex|lateral plasma membrane|myosin binding|vinculin binding|Z disc|muscle filament sliding|cell-substrate junction|filopodium|filopodium membrane|protein-containing complex|negative regulation of peptidyl-serine phosphorylation|cellular protein localization|cellular protein-containing complex assembly|maintenance of blood-brain barrier|response to muscle stretch|sarcolemma|costamere|peptide biosynthetic process|neuron projection terminus|membrane raft|synapse|postsynaptic membrane|muscle cell cellular homeostasis|muscle fiber development|nitric-oxide synthase binding|cardiac muscle contraction|regulation of ryanodine-sensitive calcium-release channel activity|cardiac muscle cell action potential|regulation of voltage-gated calcium channel activity|negative regulation of peptidyl-cysteine S-nitrosylation|positive regulation of sodium ion transmembrane transporter activity "hsa05410,hsa05412,hsa05414,hsa05416" Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis DMKN 187.5753429 160.363043 214.7876428 1.339383681 0.421569295 0.445862688 1 3.181285704 4.444507124 93099 dermokine "GO:0005515,GO:0005615,GO:1903575" protein binding|extracellular space|cornified envelope assembly DMPK 518.2461154 403.9524754 632.5397554 1.565876666 0.646970585 0.110565835 1 6.914081724 11.29296522 1760 DM1 protein kinase "GO:0002028,GO:0004674,GO:0005515,GO:0005524,GO:0005640,GO:0005789,GO:0005829,GO:0005886,GO:0006468,GO:0006874,GO:0006998,GO:0008016,GO:0010657,GO:0010830,GO:0014722,GO:0014853,GO:0017020,GO:0018105,GO:0031307,GO:0031965,GO:0033017,GO:0035556,GO:0043666,GO:0046872,GO:0051823,GO:0106310,GO:0106311,GO:1903779" regulation of sodium ion transport|protein serine/threonine kinase activity|protein binding|ATP binding|nuclear outer membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|protein phosphorylation|cellular calcium ion homeostasis|nuclear envelope organization|regulation of heart contraction|muscle cell apoptotic process|regulation of myotube differentiation|regulation of skeletal muscle contraction by calcium ion signaling|regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction|myosin phosphatase regulator activity|peptidyl-serine phosphorylation|integral component of mitochondrial outer membrane|nuclear membrane|sarcoplasmic reticulum membrane|intracellular signal transduction|regulation of phosphoprotein phosphatase activity|metal ion binding|regulation of synapse structural plasticity|protein serine kinase activity|protein threonine kinase activity|regulation of cardiac conduction DMRTA1 60.05114888 63.94222601 56.16007174 0.878293973 -0.187224191 0.832764667 1 0.579743676 0.531119017 63951 DMRT like family A1 "GO:0000785,GO:0000978,GO:0000981,GO:0001541,GO:0005515,GO:0005634,GO:0006357,GO:0007281,GO:0007548,GO:0042802,GO:0046872,GO:0060179,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|ovarian follicle development|protein binding|nucleus|regulation of transcription by RNA polymerase II|germ cell development|sex differentiation|identical protein binding|metal ion binding|male mating behavior|sequence-specific double-stranded DNA binding" DMTF1 1629.209195 1655.393184 1603.025206 0.968365232 -0.046376812 0.889408634 1 10.94228986 11.0525715 9988 cyclin D binding myb like transcription factor 1 "GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0007049,GO:0045944" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle|positive regulation of transcription by RNA polymerase II" DMTN 656.2101037 439.4759343 872.9442731 1.986330092 0.990105393 0.010234815 0.428156442 5.416866803 11.22316915 2039 dematin actin binding protein "GO:0003779,GO:0005102,GO:0005515,GO:0005829,GO:0005884,GO:0005886,GO:0007010,GO:0008360,GO:0010591,GO:0010763,GO:0010801,GO:0010812,GO:0012505,GO:0014069,GO:0014731,GO:0015629,GO:0030032,GO:0030036,GO:0030194,GO:0030507,GO:0030863,GO:0031095,GO:0031253,GO:0031410,GO:0032956,GO:0033137,GO:0035584,GO:0035585,GO:0043621,GO:0048471,GO:0048821,GO:0050732,GO:0051015,GO:0051017,GO:0051489,GO:0051693,GO:0051895,GO:0055085,GO:0065003,GO:0070560,GO:0071277,GO:0071320,GO:0090303,GO:0090315,GO:0090527,GO:1900025,GO:1900026,GO:1901731,GO:2001046" actin binding|signaling receptor binding|protein binding|cytosol|actin filament|plasma membrane|cytoskeleton organization|regulation of cell shape|regulation of lamellipodium assembly|positive regulation of fibroblast migration|negative regulation of peptidyl-threonine phosphorylation|negative regulation of cell-substrate adhesion|endomembrane system|postsynaptic density|spectrin-associated cytoskeleton|actin cytoskeleton|lamellipodium assembly|actin cytoskeleton organization|positive regulation of blood coagulation|spectrin binding|cortical cytoskeleton|platelet dense tubular network membrane|cell projection membrane|cytoplasmic vesicle|regulation of actin cytoskeleton organization|negative regulation of peptidyl-serine phosphorylation|calcium-mediated signaling using intracellular calcium source|calcium-mediated signaling using extracellular calcium source|protein self-association|perinuclear region of cytoplasm|erythrocyte development|negative regulation of peptidyl-tyrosine phosphorylation|actin filament binding|actin filament bundle assembly|regulation of filopodium assembly|actin filament capping|negative regulation of focal adhesion assembly|transmembrane transport|protein-containing complex assembly|protein secretion by platelet|cellular response to calcium ion|cellular response to cAMP|positive regulation of wound healing|negative regulation of protein targeting to membrane|actin filament reorganization|negative regulation of substrate adhesion-dependent cell spreading|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of platelet aggregation|positive regulation of integrin-mediated signaling pathway DMWD 679.9643295 581.5697699 778.3588891 1.338375771 0.420483233 0.268818912 1 8.63767073 12.05842649 1762 "DM1 locus, WD repeat containing" "GO:0003674,GO:0005575,GO:0005634,GO:0030425,GO:0043204" molecular_function|cellular_component|nucleus|dendrite|perikaryon DMXL1 1109.015561 1151.975024 1066.056099 0.925415982 -0.11182608 0.748508883 1 5.074669135 4.898472309 1657 Dmx like 1 "GO:0007035,GO:0043291" vacuolar acidification|RAVE complex DMXL2 1405.856777 1238.246281 1573.467273 1.270722389 0.345648884 0.301330425 1 5.628505285 7.460358368 23312 Dmx like 2 "GO:0005615,GO:0007035,GO:0008021,GO:0030672,GO:0031267,GO:0043291,GO:0098992" extracellular space|vacuolar acidification|synaptic vesicle|synaptic vesicle membrane|small GTPase binding|RAVE complex|neuronal dense core vesicle DNA2 629.5498191 603.8988012 655.200837 1.084951379 0.117630391 0.763909274 1 6.787692821 7.681541581 1763 DNA replication helicase/nuclease 2 "GO:0000076,GO:0000723,GO:0000729,GO:0000781,GO:0003677,GO:0003678,GO:0003723,GO:0004386,GO:0004518,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005760,GO:0006260,GO:0006264,GO:0006284,GO:0016887,GO:0016890,GO:0017108,GO:0017116,GO:0032201,GO:0032508,GO:0033567,GO:0042645,GO:0043137,GO:0043139,GO:0043504,GO:0044806,GO:0045740,GO:0046872,GO:0051539,GO:0071932,GO:0090305,GO:0090656,GO:1901796,GO:1902990" "DNA replication checkpoint|telomere maintenance|DNA double-strand break processing|chromosome, telomeric region|DNA binding|DNA helicase activity|RNA binding|helicase activity|nuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|gamma DNA polymerase complex|DNA replication|mitochondrial DNA replication|base-excision repair|ATPase activity|site-specific endodeoxyribonuclease activity, specific for altered base|5'-flap endonuclease activity|single-stranded DNA helicase activity|telomere maintenance via semi-conservative replication|DNA duplex unwinding|DNA replication, Okazaki fragment processing|mitochondrial nucleoid|DNA replication, removal of RNA primer|5'-3' DNA helicase activity|mitochondrial DNA repair|G-quadruplex DNA unwinding|positive regulation of DNA replication|metal ion binding|4 iron, 4 sulfur cluster binding|replication fork reversal|nucleic acid phosphodiester bond hydrolysis|t-circle formation|regulation of signal transduction by p53 class mediator|mitotic telomere maintenance via semi-conservative replication" hsa03030 DNA replication DNAAF10 248.3566564 240.5445645 256.1687483 1.064953385 0.090790283 0.86390272 1 3.7964268 4.217174373 116143 dynein axonemal assembly factor 10 DNAAF11 116.609335 124.8395841 108.3790858 0.868146803 -0.203989073 0.761055482 1 1.166762231 1.056553425 23639 dynein axonemal assembly factor 11 DNAAF2 353.4424555 352.189721 354.69519 1.007113975 0.010226963 0.988984554 1 5.991658354 6.294215295 55172 dynein axonemal assembly factor 2 "GO:0001539,GO:0001701,GO:0003351,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0032526,GO:0036158,GO:0036159,GO:0060285,GO:0061966,GO:0070286" cilium or flagellum-dependent cell motility|in utero embryonic development|epithelial cilium movement involved in extracellular fluid movement|protein binding|extracellular region|cytoplasm|cytosol|response to retinoic acid|outer dynein arm assembly|inner dynein arm assembly|cilium-dependent cell motility|establishment of left/right asymmetry|axonemal dynein complex assembly DNAAF3 134.5816269 141.0788796 128.0843742 0.907891915 -0.139407541 0.830690253 1 3.234562044 3.063130956 352909 dynein axonemal assembly factor 3 "GO:0005737,GO:0044458,GO:0070286" cytoplasm|motile cilium assembly|axonemal dynein complex assembly DNAAF4 62.90302169 56.83753423 68.96850916 1.213432463 0.279093814 0.737187942 1 1.213583726 1.536035607 161582 dynein axonemal assembly factor 4 "GO:0001764,GO:0003341,GO:0003351,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0007368,GO:0007507,GO:0030331,GO:0033146,GO:0036158,GO:0036159,GO:0061136,GO:0097730" neuron migration|cilium movement|epithelial cilium movement involved in extracellular fluid movement|protein binding|extracellular region|nucleus|cytoplasm|centrosome|cytosol|plasma membrane|determination of left/right symmetry|heart development|estrogen receptor binding|regulation of intracellular estrogen receptor signaling pathway|outer dynein arm assembly|inner dynein arm assembly|regulation of proteasomal protein catabolic process|non-motile cilium DNAAF5 1944.46783 2158.811345 1730.124315 0.801424506 -0.31936147 0.322786524 1 28.02773104 23.42968712 54919 dynein axonemal assembly factor 5 "GO:0003341,GO:0005737,GO:0031514,GO:0036158,GO:0036159,GO:0045505" cilium movement|cytoplasm|motile cilium|outer dynein arm assembly|inner dynein arm assembly|dynein intermediate chain binding DNAAF8 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.088292579 0.035760676 146562 dynein axonemal assembly factor 8 DNAAF9 1759.072587 1440.222519 2077.922654 1.442778895 0.528850224 0.104875042 1 9.615369074 14.47043775 25943 dynein axonemal assembly factor 9 DNAH1 74.12692045 83.22638941 65.02745149 0.781332123 -0.355992167 0.643332668 1 0.255106398 0.207908843 25981 dynein axonemal heavy chain 1 "GO:0003341,GO:0003777,GO:0005524,GO:0005858,GO:0005874,GO:0005930,GO:0007018,GO:0007288,GO:0008569,GO:0030286,GO:0030317,GO:0036126,GO:0036156,GO:0036159,GO:0045505,GO:0051959,GO:0060285" "cilium movement|microtubule motor activity|ATP binding|axonemal dynein complex|microtubule|axoneme|microtubule-based movement|sperm axoneme assembly|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|flagellated sperm motility|sperm flagellum|inner dynein arm|inner dynein arm assembly|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH10 4.52276453 6.08973581 2.95579325 0.485372985 -1.042834281 0.660953233 1 0.021491439 0.010880705 196385 dynein axonemal heavy chain 10 "GO:0005524,GO:0005874,GO:0005930,GO:0007018,GO:0008569,GO:0030286,GO:0045505,GO:0051959" "ATP binding|microtubule|axoneme|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|dynein intermediate chain binding|dynein light intermediate chain binding" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH11 7.537940883 10.14955968 4.926322083 0.485372985 -1.042834281 0.538494358 1 0.035839043 0.018144622 8701 dynein axonemal heavy chain 11 "GO:0003341,GO:0003356,GO:0005524,GO:0005874,GO:0005930,GO:0007018,GO:0007368,GO:0008569,GO:0030286,GO:0030317,GO:0031514,GO:0045505,GO:0051959,GO:0097729,GO:0120134" "cilium movement|regulation of cilium beat frequency|ATP binding|microtubule|axoneme|microtubule-based movement|determination of left/right symmetry|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|flagellated sperm motility|motile cilium|dynein intermediate chain binding|dynein light intermediate chain binding|9+2 motile cilium|proximal portion of axoneme" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH14 188.4836568 188.7818101 188.1855036 0.996841292 -0.004564264 1 1 0.448816256 0.466670693 127602 dynein axonemal heavy chain 14 "GO:0005524,GO:0005858,GO:0005874,GO:0007018,GO:0008569,GO:0030286,GO:0045505,GO:0051959,GO:0060285" "ATP binding|axonemal dynein complex|microtubule|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH17 23.26975839 41.6131947 4.926322083 0.118383655 -3.078458191 0.008744349 0.39115812 0.15264442 0.018849013 8632 dynein axonemal heavy chain 17 "GO:0003341,GO:0003777,GO:0005524,GO:0005858,GO:0005874,GO:0005930,GO:0007018,GO:0008569,GO:0030286,GO:0031514,GO:0036126,GO:0036157,GO:0036158,GO:0045505,GO:0051959,GO:0060285" "cilium movement|microtubule motor activity|ATP binding|axonemal dynein complex|microtubule|axoneme|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|motile cilium|sperm flagellum|outer dynein arm|outer dynein arm assembly|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH3 24.31712752 12.17947162 36.45478341 2.993133409 1.581656584 0.138148882 1 0.042304867 0.132078565 55567 dynein axonemal heavy chain 3 "GO:0003777,GO:0005524,GO:0005858,GO:0005874,GO:0007018,GO:0008569,GO:0030286,GO:0045505,GO:0051959,GO:0060285" "microtubule motor activity|ATP binding|axonemal dynein complex|microtubule|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH5 95.78517023 115.7049804 75.86536007 0.655679296 -0.608937755 0.377978681 1 0.292300931 0.199911418 1767 dynein axonemal heavy chain 5 "GO:0003341,GO:0003351,GO:0005524,GO:0005576,GO:0005737,GO:0005874,GO:0005930,GO:0007018,GO:0007368,GO:0007507,GO:0008569,GO:0021670,GO:0030286,GO:0030317,GO:0031514,GO:0036157,GO:0036158,GO:0045505,GO:0051649,GO:0051959,GO:0060271,GO:0097729" "cilium movement|epithelial cilium movement involved in extracellular fluid movement|ATP binding|extracellular region|cytoplasm|microtubule|axoneme|microtubule-based movement|determination of left/right symmetry|heart development|ATP-dependent microtubule motor activity, minus-end-directed|lateral ventricle development|dynein complex|flagellated sperm motility|motile cilium|outer dynein arm|outer dynein arm assembly|dynein intermediate chain binding|establishment of localization in cell|dynein light intermediate chain binding|cilium assembly|9+2 motile cilium" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH7 26.19586009 39.58328277 12.80843742 0.32358199 -1.627796782 0.118486837 1 0.158165967 0.05338427 56171 dynein axonemal heavy chain 7 "GO:0003341,GO:0003777,GO:0005509,GO:0005524,GO:0005829,GO:0005858,GO:0005874,GO:0005929,GO:0007018,GO:0008569,GO:0030286,GO:0036156,GO:0036159,GO:0045505,GO:0051959,GO:0060285" "cilium movement|microtubule motor activity|calcium ion binding|ATP binding|cytosol|axonemal dynein complex|microtubule|cilium|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|inner dynein arm|inner dynein arm assembly|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAI1 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.060689421 0 27019 dynein axonemal intermediate chain 1 "GO:0003341,GO:0003774,GO:0005515,GO:0005856,GO:0005874,GO:0005929,GO:0007018,GO:0007368,GO:0030317,GO:0036157,GO:0036158,GO:0045503,GO:0045504" cilium movement|motor activity|protein binding|cytoskeleton|microtubule|cilium|microtubule-based movement|determination of left/right symmetry|flagellated sperm motility|outer dynein arm|outer dynein arm assembly|dynein light chain binding|dynein heavy chain binding "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAI3 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.085959765 0.087039571 126820 dynein axonemal intermediate chain 3 "GO:0005515,GO:0005737,GO:0005858,GO:0007018,GO:0030336,GO:0034316,GO:0036156,GO:0036159,GO:0045503,GO:0045504,GO:0045669,GO:0060294,GO:0071933" protein binding|cytoplasm|axonemal dynein complex|microtubule-based movement|negative regulation of cell migration|negative regulation of Arp2/3 complex-mediated actin nucleation|inner dynein arm|inner dynein arm assembly|dynein light chain binding|dynein heavy chain binding|positive regulation of osteoblast differentiation|cilium movement involved in cell motility|Arp2/3 complex binding DNAI4 17.4202766 12.17947162 22.66108158 1.860596443 0.895765174 0.45402894 1 0.144867842 0.281151307 79819 dynein axonemal intermediate chain 4 "GO:0002244,GO:0003341,GO:0005858,GO:0005930,GO:0007018,GO:0031514,GO:0045503,GO:0045504,GO:0070286" hematopoietic progenitor cell differentiation|cilium movement|axonemal dynein complex|axoneme|microtubule-based movement|motile cilium|dynein light chain binding|dynein heavy chain binding|axonemal dynein complex assembly DNAI7 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.076539516 0.046500593 55259 dynein axonemal intermediate chain 7 DNAJA1 7507.80272 7920.716377 7094.889064 0.895738305 -0.158850792 0.62940921 1 172.9867796 161.6255405 3301 DnaJ heat shock protein family (Hsp40) member A1 "GO:0001664,GO:0001671,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005829,GO:0006457,GO:0006986,GO:0007283,GO:0009408,GO:0015630,GO:0016020,GO:0030317,GO:0030521,GO:0030544,GO:0030957,GO:0031397,GO:0031625,GO:0032781,GO:0042769,GO:0043065,GO:0043066,GO:0043508,GO:0046872,GO:0048471,GO:0050750,GO:0051082,GO:0051087,GO:0051223,GO:0055131,GO:0070062,GO:0070585,GO:0098554,GO:1901998,GO:1903748,GO:1905259" "G protein-coupled receptor binding|ATPase activator activity|protein binding|ATP binding|nucleus|mitochondrion|cytosol|protein folding|response to unfolded protein|spermatogenesis|response to heat|microtubule cytoskeleton|membrane|flagellated sperm motility|androgen receptor signaling pathway|Hsp70 protein binding|Tat protein binding|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|positive regulation of ATPase activity|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of JUN kinase activity|metal ion binding|perinuclear region of cytoplasm|low-density lipoprotein particle receptor binding|unfolded protein binding|chaperone binding|regulation of protein transport|C3HC4-type RING finger domain binding|extracellular exosome|protein localization to mitochondrion|cytoplasmic side of endoplasmic reticulum membrane|toxin transport|negative regulation of establishment of protein localization to mitochondrion|negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" hsa04141 Protein processing in endoplasmic reticulum DNAJA2 1484.383491 1554.912544 1413.854438 0.90928229 -0.137199842 0.680430745 1 26.18046374 24.83087348 10294 DnaJ heat shock protein family (Hsp40) member A2 "GO:0001671,GO:0005515,GO:0005524,GO:0005829,GO:0008284,GO:0009408,GO:0016020,GO:0031072,GO:0032781,GO:0042026,GO:0046872,GO:0051082,GO:0051087,GO:0070062" ATPase activator activity|protein binding|ATP binding|cytosol|positive regulation of cell population proliferation|response to heat|membrane|heat shock protein binding|positive regulation of ATPase activity|protein refolding|metal ion binding|unfolded protein binding|chaperone binding|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum DNAJA3 1044.325603 1040.329868 1048.321339 1.007681671 0.01103996 0.977863377 1 19.51445842 20.51142303 9093 DnaJ heat shock protein family (Hsp40) member A3 "GO:0000122,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0005884,GO:0006264,GO:0006457,GO:0006924,GO:0007005,GO:0007264,GO:0007569,GO:0008285,GO:0009408,GO:0019897,GO:0030544,GO:0030695,GO:0031594,GO:0033077,GO:0042102,GO:0042981,GO:0043069,GO:0043231,GO:0045211,GO:0046872,GO:0050790,GO:0051082,GO:0071340" negative regulation of transcription by RNA polymerase II|protein binding|ATP binding|nucleus|mitochondrion|mitochondrial matrix|cytosol|actin filament|mitochondrial DNA replication|protein folding|activation-induced cell death of T cells|mitochondrion organization|small GTPase mediated signal transduction|cell aging|negative regulation of cell population proliferation|response to heat|extrinsic component of plasma membrane|Hsp70 protein binding|GTPase regulator activity|neuromuscular junction|T cell differentiation in thymus|positive regulation of T cell proliferation|regulation of apoptotic process|negative regulation of programmed cell death|intracellular membrane-bounded organelle|postsynaptic membrane|metal ion binding|regulation of catalytic activity|unfolded protein binding|skeletal muscle acetylcholine-gated channel clustering hsa05203 Viral carcinogenesis DNAJA4 604.7482242 491.2386887 718.2577597 1.462135976 0.548077486 0.160459493 1 7.460121918 11.37757267 55466 DnaJ heat shock protein family (Hsp40) member A4 "GO:0005515,GO:0005524,GO:0005829,GO:0009408,GO:0010596,GO:0010628,GO:0016020,GO:0031072,GO:0042026,GO:0046872,GO:0051082,GO:0051087,GO:0090084" protein binding|ATP binding|cytosol|response to heat|negative regulation of endothelial cell migration|positive regulation of gene expression|membrane|heat shock protein binding|protein refolding|metal ion binding|unfolded protein binding|chaperone binding|negative regulation of inclusion body assembly DNAJB1 2179.279203 2281.621017 2076.93739 0.910290261 -0.13560145 0.672976417 1 28.30175249 26.87256701 3337 DnaJ heat shock protein family (Hsp40) member B1 "GO:0000122,GO:0001671,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006986,GO:0014069,GO:0030544,GO:0030900,GO:0032781,GO:0043025,GO:0043197,GO:0044183,GO:0045296,GO:0051082,GO:0051085,GO:0051087,GO:0051117,GO:0061827,GO:0070062,GO:0090084,GO:0097201,GO:0098978,GO:1900034" negative regulation of transcription by RNA polymerase II|ATPase activator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|response to unfolded protein|postsynaptic density|Hsp70 protein binding|forebrain development|positive regulation of ATPase activity|neuronal cell body|dendritic spine|protein folding chaperone|cadherin binding|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|ATPase binding|sperm head|extracellular exosome|negative regulation of inclusion body assembly|negative regulation of transcription from RNA polymerase II promoter in response to stress|glutamatergic synapse|regulation of cellular response to heat "hsa04141,hsa05164" Protein processing in endoplasmic reticulum|Influenza A DNAJB11 2113.752439 2180.12542 2047.379458 0.93911086 -0.09063262 0.778763261 1 67.32662287 65.95073243 51726 DnaJ heat shock protein family (Hsp40) member B11 "GO:0005515,GO:0005783,GO:0005788,GO:0006457,GO:0016020,GO:0032781,GO:0036498,GO:0051082,GO:0051604,GO:0051787,GO:0101031" protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|membrane|positive regulation of ATPase activity|IRE1-mediated unfolded protein response|unfolded protein binding|protein maturation|misfolded protein binding|chaperone complex hsa04141 Protein processing in endoplasmic reticulum DNAJB12 2381.617429 2272.486413 2490.748445 1.096045473 0.132307654 0.67937059 1 28.09212106 32.11656086 54788 DnaJ heat shock protein family (Hsp40) member B12 "GO:0005783,GO:0005789,GO:0016020,GO:0016032,GO:0030176,GO:0030433,GO:0030544,GO:0031965,GO:0034622,GO:0036503,GO:0051085,GO:0071218" endoplasmic reticulum|endoplasmic reticulum membrane|membrane|viral process|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|nuclear membrane|cellular protein-containing complex assembly|ERAD pathway|chaperone cofactor-dependent protein refolding|cellular response to misfolded protein hsa04141 Protein processing in endoplasmic reticulum DNAJB14 659.1874237 541.9864871 776.3883602 1.432486563 0.518521607 0.17567509 1 4.278987305 6.393629774 79982 DnaJ heat shock protein family (Hsp40) member B14 "GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0016032,GO:0030433,GO:0030544,GO:0031965,GO:0034622,GO:0051085,GO:0071218" endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|viral process|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|nuclear membrane|cellular protein-containing complex assembly|chaperone cofactor-dependent protein refolding|cellular response to misfolded protein DNAJB2 708.4585632 811.9647747 604.9523518 0.745047532 -0.424595626 0.259860944 1 21.40715846 16.63638392 3300 DnaJ heat shock protein family (Hsp40) member B2 "GO:0000502,GO:0001671,GO:0005515,GO:0005634,GO:0005829,GO:0006986,GO:0008285,GO:0030308,GO:0030433,GO:0030544,GO:0031227,GO:0031396,GO:0031965,GO:0032091,GO:0032436,GO:0032781,GO:0042026,GO:0043130,GO:0051082,GO:0051087,GO:0061077,GO:0070050,GO:0090084,GO:0140036,GO:1903644" proteasome complex|ATPase activator activity|protein binding|nucleus|cytosol|response to unfolded protein|negative regulation of cell population proliferation|negative regulation of cell growth|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|intrinsic component of endoplasmic reticulum membrane|regulation of protein ubiquitination|nuclear membrane|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ATPase activity|protein refolding|ubiquitin binding|unfolded protein binding|chaperone binding|chaperone-mediated protein folding|neuron cellular homeostasis|negative regulation of inclusion body assembly|ubiquitin-dependent protein binding|regulation of chaperone-mediated protein folding hsa04141 Protein processing in endoplasmic reticulum DNAJB4 182.8568617 174.5724266 191.1412968 1.094911153 0.130813806 0.821907305 1 2.700512386 3.084188992 11080 DnaJ heat shock protein family (Hsp40) member B4 "GO:0001671,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006986,GO:0009408,GO:0032781,GO:0051082,GO:0051085,GO:0051087" ATPase activator activity|protein binding|nucleoplasm|cytosol|plasma membrane|response to unfolded protein|response to heat|positive regulation of ATPase activity|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding DNAJB5 802.1289523 682.0504107 922.2074939 1.352110459 0.435213016 0.236073016 1 11.62296338 16.39249167 25822 DnaJ heat shock protein family (Hsp40) member B5 "GO:0005515,GO:0005829,GO:0006986,GO:0051082,GO:0051085,GO:0051087" protein binding|cytosol|response to unfolded protein|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding DNAJB6 3204.502752 3430.551173 2978.454331 0.868214517 -0.203876549 0.521706969 1 60.05714299 54.38857013 10049 DnaJ heat shock protein family (Hsp40) member B6 "GO:0001671,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006457,GO:0016020,GO:0030018,GO:0031072,GO:0032781,GO:0032880,GO:0043154,GO:0045109,GO:0048471,GO:0051082,GO:0051087,GO:0090084,GO:1900034" ATPase activator activity|protein binding|nucleus|nucleoplasm|cytosol|protein folding|membrane|Z disc|heat shock protein binding|positive regulation of ATPase activity|regulation of protein localization|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|intermediate filament organization|perinuclear region of cytoplasm|unfolded protein binding|chaperone binding|negative regulation of inclusion body assembly|regulation of cellular response to heat DNAJB9 260.7912278 248.6642123 272.9182434 1.097537281 0.134269946 0.792047318 1 5.227880912 5.984955105 4189 DnaJ heat shock protein family (Hsp40) member B9 "GO:0002377,GO:0005515,GO:0005730,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0030183,GO:0030433,GO:0030544,GO:0034976,GO:0036498,GO:0051087,GO:0051787,GO:0070062,GO:1903895" immunoglobulin production|protein binding|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|B cell differentiation|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|chaperone binding|misfolded protein binding|extracellular exosome|negative regulation of IRE1-mediated unfolded protein response DNAJC1 699.4590553 600.8539333 798.0641774 1.328216615 0.409490451 0.278590435 1 11.03777005 15.2920666 64215 DnaJ heat shock protein family (Hsp40) member C1 "GO:0001671,GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006417,GO:0006457,GO:0016020,GO:0016021,GO:0031965,GO:0032781,GO:0045861,GO:0050708,GO:0051087" ATPase activator activity|DNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|regulation of translation|protein folding|membrane|integral component of membrane|nuclear membrane|positive regulation of ATPase activity|negative regulation of proteolysis|regulation of protein secretion|chaperone binding hsa04141 Protein processing in endoplasmic reticulum DNAJC10 2942.449633 3095.615704 2789.283563 0.901043227 -0.150331775 0.637008551 1 7.783062684 7.31496217 54431 DnaJ heat shock protein family (Hsp40) member C10 "GO:0001671,GO:0001933,GO:0005515,GO:0005783,GO:0005788,GO:0015035,GO:0015036,GO:0016020,GO:0016671,GO:0030433,GO:0030544,GO:0032781,GO:0034663,GO:0034975,GO:0034976,GO:0051087,GO:0051117,GO:0051787,GO:0055114,GO:0070059" "ATPase activator activity|negative regulation of protein phosphorylation|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein disulfide oxidoreductase activity|disulfide oxidoreductase activity|membrane|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|positive regulation of ATPase activity|endoplasmic reticulum chaperone complex|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|chaperone binding|ATPase binding|misfolded protein binding|oxidation-reduction process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" hsa04141 Protein processing in endoplasmic reticulum DNAJC11 1525.208375 1786.322504 1264.094246 0.70765175 -0.49888854 0.131882158 1 28.24568626 20.849116 55735 DnaJ heat shock protein family (Hsp40) member C11 "GO:0001401,GO:0005515,GO:0005654,GO:0005739,GO:0007007,GO:0016607,GO:0042407,GO:0061617,GO:0140275" SAM complex|protein binding|nucleoplasm|mitochondrion|inner mitochondrial membrane organization|nuclear speck|cristae formation|MICOS complex|MIB complex DNAJC12 133.4209348 95.40586103 171.4360085 1.796912754 0.845520363 0.170759459 1 2.949920812 5.529085156 56521 DnaJ heat shock protein family (Hsp40) member C12 "GO:0005515,GO:0005737" protein binding|cytoplasm DNAJC13 1742.654896 1766.023385 1719.286407 0.97353547 -0.038694551 0.9072218 1 11.44795268 11.62506888 23317 DnaJ heat shock protein family (Hsp40) member C13 "GO:0001649,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0006898,GO:0007032,GO:0010008,GO:0015031,GO:0016020,GO:0030667,GO:0031901,GO:0035577,GO:0043231,GO:0043312,GO:0070062,GO:0071203,GO:1902954,GO:2000641" osteoblast differentiation|protein binding|lysosomal membrane|cytosol|plasma membrane|receptor-mediated endocytosis|endosome organization|endosome membrane|protein transport|membrane|secretory granule membrane|early endosome membrane|azurophil granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|WASH complex|regulation of early endosome to recycling endosome transport|regulation of early endosome to late endosome transport DNAJC14 1365.702428 1389.474721 1341.930135 0.965782332 -0.050230024 0.883046902 1 21.61301991 21.77261731 85406 DnaJ heat shock protein family (Hsp40) member C14 "GO:0005789,GO:0015031,GO:0016020,GO:0016021" endoplasmic reticulum membrane|protein transport|membrane|integral component of membrane DNAJC15 290.7499963 276.0680234 305.4319691 1.106364893 0.145827283 0.765381073 1 1.874496779 2.163211657 29103 DnaJ heat shock protein family (Hsp40) member C15 "GO:0001405,GO:0001671,GO:0005515,GO:0009267,GO:0016021,GO:0019216,GO:0030150,GO:0031333,GO:0032781,GO:1902957" "PAM complex, Tim23 associated import motor|ATPase activator activity|protein binding|cellular response to starvation|integral component of membrane|regulation of lipid metabolic process|protein import into mitochondrial matrix|negative regulation of protein-containing complex assembly|positive regulation of ATPase activity|negative regulation of mitochondrial electron transport, NADH to ubiquinone" DNAJC16 447.3461715 473.9844372 420.7079059 0.887598564 -0.172020761 0.685560618 1 3.978395696 3.68332887 23341 DnaJ heat shock protein family (Hsp40) member C16 GO:0016021 integral component of membrane DNAJC17 174.6305719 184.7219862 164.5391576 0.890739434 -0.166924629 0.774615969 1 1.825110601 1.695726461 55192 DnaJ heat shock protein family (Hsp40) member C17 "GO:0000122,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:1901998" negative regulation of transcription by RNA polymerase II|RNA binding|protein binding|nucleus|cytoplasm|toxin transport DNAJC18 522.2356698 541.9864871 502.4848524 0.927116938 -0.109176776 0.790721486 1 5.380184939 5.202926008 202052 DnaJ heat shock protein family (Hsp40) member C18 "GO:0005789,GO:0016021,GO:0030433,GO:0030544,GO:0051085,GO:0071218" endoplasmic reticulum membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|chaperone cofactor-dependent protein refolding|cellular response to misfolded protein DNAJC19 421.687481 437.4460224 405.9289396 0.927952065 -0.107877813 0.805121488 1 12.40487 12.00697729 131118 DnaJ heat shock protein family (Hsp40) member C19 "GO:0001405,GO:0001671,GO:0005515,GO:0005739,GO:0005743,GO:0006457,GO:0006626,GO:0007601,GO:0016021,GO:0030150,GO:0032781,GO:0032991,GO:0048806,GO:0098800,GO:0099617,GO:1900208" "PAM complex, Tim23 associated import motor|ATPase activator activity|protein binding|mitochondrion|mitochondrial inner membrane|protein folding|protein targeting to mitochondrion|visual perception|integral component of membrane|protein import into mitochondrial matrix|positive regulation of ATPase activity|protein-containing complex|genitalia development|inner mitochondrial membrane protein complex|matrix side of mitochondrial inner membrane|regulation of cardiolipin metabolic process" DNAJC2 496.8414816 557.2108266 436.4721365 0.783315965 -0.352333732 0.389943086 1 12.17987166 9.951662073 27000 DnaJ heat shock protein family (Hsp40) member C2 "GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006260,GO:0006325,GO:0030544,GO:0031965,GO:0042393,GO:0045893,GO:0051083,GO:0061649,GO:1900034,GO:2000279" "chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|DNA replication|chromatin organization|Hsp70 protein binding|nuclear membrane|histone binding|positive regulation of transcription, DNA-templated|'de novo' cotranslational protein folding|ubiquitin modification-dependent histone binding|regulation of cellular response to heat|negative regulation of DNA biosynthetic process" DNAJC21 1105.426843 1041.344824 1169.508862 1.123075504 0.167454923 0.630085006 1 6.118380704 7.167395687 134218 DnaJ heat shock protein family (Hsp40) member C21 "GO:0003723,GO:0005515,GO:0005730,GO:0005829,GO:0005840,GO:0006457,GO:0008270" RNA binding|protein binding|nucleolus|cytosol|ribosome|protein folding|zinc ion binding DNAJC22 74.27809981 59.88240213 88.67379749 1.480798938 0.566375766 0.452953433 1 1.34136772 2.071857467 79962 DnaJ heat shock protein family (Hsp40) member C22 "GO:0005515,GO:0016021" protein binding|integral component of membrane DNAJC24 374.3556949 367.4140606 381.2973292 1.037786438 0.053509588 0.909657359 1 6.265395962 6.782228907 120526 DnaJ heat shock protein family (Hsp40) member C24 "GO:0001671,GO:0005737,GO:0005856,GO:0008198,GO:0008270,GO:0017183,GO:0032781,GO:0055114,GO:0061077" ATPase activator activity|cytoplasm|cytoskeleton|ferrous iron binding|zinc ion binding|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|positive regulation of ATPase activity|oxidation-reduction process|chaperone-mediated protein folding DNAJC25 130.6675392 176.6023385 84.73273982 0.479793985 -1.059513022 0.088910824 1 3.922932206 1.963276789 548645 DnaJ heat shock protein family (Hsp40) member C25 "GO:0005789,GO:0006457,GO:0016021" endoplasmic reticulum membrane|protein folding|integral component of membrane DNAJC27 103.3258327 92.36099312 114.2906723 1.237434424 0.307352074 0.654414572 1 0.921544222 1.18947222 51277 DnaJ heat shock protein family (Hsp40) member C27 "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0006886,GO:0070374,GO:0071701" GTPase activity|protein binding|GTP binding|nucleus|intracellular protein transport|positive regulation of ERK1 and ERK2 cascade|regulation of MAPK export from nucleus DNAJC28 30.91434131 25.37389921 36.45478341 1.436704036 0.522762895 0.608580815 1 0.705710314 1.057571421 54943 DnaJ heat shock protein family (Hsp40) member C28 "GO:0005515,GO:0006890,GO:0007030,GO:0017119,GO:0048213" "protein binding|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|Golgi transport complex|Golgi vesicle prefusion complex stabilization" DNAJC3 1390.853641 1424.99818 1356.709102 0.952077779 -0.070848657 0.834173142 1 10.57297549 10.49991019 5611 DnaJ heat shock protein family (Hsp40) member C3 "GO:0004860,GO:0005576,GO:0005737,GO:0005783,GO:0005788,GO:0005790,GO:0005829,GO:0006469,GO:0016020,GO:0019901,GO:0034975,GO:0035578,GO:0036494,GO:0036498,GO:0043066,GO:0043312,GO:0043687,GO:0044267,GO:0051087,GO:0051603,GO:0051607,GO:0051787,GO:0070062,GO:0070417,GO:1903561,GO:1903912" protein kinase inhibitor activity|extracellular region|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|smooth endoplasmic reticulum|cytosol|negative regulation of protein kinase activity|membrane|protein kinase binding|protein folding in endoplasmic reticulum|azurophil granule lumen|positive regulation of translation initiation in response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|negative regulation of apoptotic process|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|chaperone binding|proteolysis involved in cellular protein catabolic process|defense response to virus|misfolded protein binding|extracellular exosome|cellular response to cold|extracellular vesicle|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation "hsa04141,hsa05164" Protein processing in endoplasmic reticulum|Influenza A DNAJC30 296.7155227 347.1149412 246.3161041 0.709609628 -0.494902511 0.297446582 1 6.932234709 5.131078835 84277 DnaJ heat shock protein family (Hsp40) member C30 "GO:0005515,GO:0005743,GO:0006754,GO:0007420,GO:0016021,GO:1905706" protein binding|mitochondrial inner membrane|ATP biosynthetic process|brain development|integral component of membrane|regulation of mitochondrial ATP synthesis coupled proton transport DNAJC4 406.4307283 438.4609783 374.4004783 0.853896919 -0.227866175 0.600079206 1 17.77942494 15.83576638 3338 DnaJ heat shock protein family (Hsp40) member C4 "GO:0005515,GO:0006457,GO:0006986,GO:0016020,GO:0016021,GO:0051082" protein binding|protein folding|response to unfolded protein|membrane|integral component of membrane|unfolded protein binding DNAJC5 5106.457238 5377.23672 4835.677756 0.899286754 -0.153146876 0.633923445 1 40.20937105 37.71737036 80331 DnaJ heat shock protein family (Hsp40) member C5 "GO:0005515,GO:0005739,GO:0005765,GO:0005794,GO:0005829,GO:0005886,GO:0006887,GO:0007269,GO:0016020,GO:0016079,GO:0031225,GO:0031594,GO:0035577,GO:0035579,GO:0042470,GO:0042584,GO:0043008,GO:0043231,GO:0043312,GO:0043524,GO:0045055,GO:0061077,GO:0061202,GO:0098693,GO:0098993" protein binding|mitochondrion|lysosomal membrane|Golgi apparatus|cytosol|plasma membrane|exocytosis|neurotransmitter secretion|membrane|synaptic vesicle exocytosis|anchored component of membrane|neuromuscular junction|azurophil granule membrane|specific granule membrane|melanosome|chromaffin granule membrane|ATP-dependent protein binding|intracellular membrane-bounded organelle|neutrophil degranulation|negative regulation of neuron apoptotic process|regulated exocytosis|chaperone-mediated protein folding|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|regulation of synaptic vesicle cycle|anchored component of synaptic vesicle membrane hsa04141 Protein processing in endoplasmic reticulum DNAJC6 88.51989652 56.83753423 120.2022588 2.114839436 1.080548134 0.127536308 1 0.459917015 1.014548486 9829 DnaJ heat shock protein family (Hsp40) member C6 "GO:0004725,GO:0005737,GO:0005829,GO:0014069,GO:0016191,GO:0017124,GO:0030276,GO:0031982,GO:0035335,GO:0043231,GO:0061024,GO:0072318,GO:0072583,GO:0098793,GO:2000369" protein tyrosine phosphatase activity|cytoplasm|cytosol|postsynaptic density|synaptic vesicle uncoating|SH3 domain binding|clathrin binding|vesicle|peptidyl-tyrosine dephosphorylation|intracellular membrane-bounded organelle|membrane organization|clathrin coat disassembly|clathrin-dependent endocytosis|presynapse|regulation of clathrin-dependent endocytosis hsa04144 Endocytosis DNAJC7 2041.430022 2119.228062 1963.631982 0.926578889 -0.110014283 0.733354212 1 49.23459869 47.5848531 7266 DnaJ heat shock protein family (Hsp40) member C7 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006457,GO:0016020,GO:0031072,GO:0051085,GO:0070062,GO:1900034" protein binding|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein folding|membrane|heat shock protein binding|chaperone cofactor-dependent protein refolding|extracellular exosome|regulation of cellular response to heat DNAJC8 1694.45389 1737.604618 1651.303162 0.950333088 -0.073494834 0.823572847 1 49.91692796 49.48113237 22826 DnaJ heat shock protein family (Hsp40) member C8 "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0030544,GO:0045171" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|cytosol|Hsp70 protein binding|intercellular bridge" DNAJC9 2374.080972 2060.360616 2687.801328 1.30452956 0.383529636 0.230151161 1 45.46840814 61.86992706 23234 DnaJ heat shock protein family (Hsp40) member C9 "GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0031072,GO:0032781" protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|heat shock protein binding|positive regulation of ATPase activity DNAL1 375.6257506 353.204677 398.0468243 1.126957966 0.172433706 0.699865495 1 2.592922287 3.047987264 83544 dynein axonemal light chain 1 "GO:0003774,GO:0005515,GO:0005737,GO:0005874,GO:0036157,GO:0036158,GO:0043014,GO:0045504" motor activity|protein binding|cytoplasm|microtubule|outer dynein arm|outer dynein arm assembly|alpha-tubulin binding|dynein heavy chain binding "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAL4 205.3519181 196.9014579 213.8023784 1.08583441 0.118804109 0.831860405 1 6.765511679 7.66267098 10126 dynein axonemal light chain 4 "GO:0003777,GO:0005515,GO:0005737,GO:0005874,GO:0005886,GO:0005929,GO:0007018,GO:0030286,GO:0042802,GO:0045505,GO:0051959,GO:2000582" "microtubule motor activity|protein binding|cytoplasm|microtubule|plasma membrane|cilium|microtubule-based movement|dynein complex|identical protein binding|dynein intermediate chain binding|dynein light intermediate chain binding|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNASE1 428.7760892 282.1577592 575.3944193 2.039264916 1.028049205 0.016343388 0.564119327 1.486095581 3.161086065 1773 deoxyribonuclease 1 "GO:0000737,GO:0002283,GO:0002673,GO:0003677,GO:0003779,GO:0004530,GO:0005515,GO:0005576,GO:0005634,GO:0005635,GO:0006308,GO:0006915,GO:0070062,GO:0070948" "DNA catabolic process, endonucleolytic|neutrophil activation involved in immune response|regulation of acute inflammatory response|DNA binding|actin binding|deoxyribonuclease I activity|protein binding|extracellular region|nucleus|nuclear envelope|DNA catabolic process|apoptotic process|extracellular exosome|regulation of neutrophil mediated cytotoxicity" DNASE1L1 551.3724773 580.5548139 522.1901408 0.89946742 -0.152857069 0.704311566 1 7.556682922 7.089776861 1774 deoxyribonuclease 1 like 1 "GO:0000737,GO:0003677,GO:0004530,GO:0004536,GO:0005515,GO:0005576,GO:0005634,GO:0005783,GO:0006259,GO:0006308,GO:0035580,GO:0043312" "DNA catabolic process, endonucleolytic|DNA binding|deoxyribonuclease I activity|deoxyribonuclease activity|protein binding|extracellular region|nucleus|endoplasmic reticulum|DNA metabolic process|DNA catabolic process|specific granule lumen|neutrophil degranulation" DNASE1L2 23.92841574 19.2841634 28.57266808 1.481664902 0.5672192 0.609483674 1 0.723999144 1.118932726 1775 deoxyribonuclease 1 like 2 "GO:0000737,GO:0001942,GO:0003335,GO:0003677,GO:0004530,GO:0004536,GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0006259,GO:0006308" "DNA catabolic process, endonucleolytic|hair follicle development|corneocyte development|DNA binding|deoxyribonuclease I activity|deoxyribonuclease activity|calcium ion binding|extracellular region|nucleus|cytoplasm|DNA metabolic process|DNA catabolic process" DNASE2 1088.592233 1170.244232 1006.940234 0.860453063 -0.216831598 0.53325667 1 30.58242619 27.44827467 1777 "deoxyribonuclease 2, lysosomal" "GO:0003677,GO:0004531,GO:0005764,GO:0006259,GO:0006309,GO:0030218,GO:0050776,GO:0070062" DNA binding|deoxyribonuclease II activity|lysosome|DNA metabolic process|apoptotic DNA fragmentation|erythrocyte differentiation|regulation of immune response|extracellular exosome hsa04142 Lysosome DND1 20.95777671 18.26920743 23.646346 1.294327961 0.372203218 0.766546876 1 0.580107151 0.783192432 373863 DND microRNA-mediated repression inhibitor 1 "GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0007275,GO:0007281,GO:0035198,GO:0048255,GO:0060965,GO:0061158" RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|multicellular organism development|germ cell development|miRNA binding|mRNA stabilization|negative regulation of gene silencing by miRNA|3'-UTR-mediated mRNA destabilization DNER 2345.412548 1952.775283 2738.049814 1.402132563 0.487622754 0.127472708 1 30.6195601 44.78204812 92737 delta/notch like EGF repeat containing "GO:0001764,GO:0004888,GO:0005112,GO:0005509,GO:0005515,GO:0005769,GO:0005886,GO:0006897,GO:0007219,GO:0007220,GO:0007416,GO:0007417,GO:0010001,GO:0016021,GO:0030276,GO:0030425,GO:0043025,GO:0048741" neuron migration|transmembrane signaling receptor activity|Notch binding|calcium ion binding|protein binding|early endosome|plasma membrane|endocytosis|Notch signaling pathway|Notch receptor processing|synapse assembly|central nervous system development|glial cell differentiation|integral component of membrane|clathrin binding|dendrite|neuronal cell body|skeletal muscle fiber development DNHD1 166.1667497 178.6322504 153.701249 0.860433928 -0.216863681 0.711578964 1 0.576799063 0.517675967 144132 dynein heavy chain domain 1 "GO:0003341,GO:0005524,GO:0007018,GO:0008569,GO:0030286,GO:0036156,GO:0045505,GO:0051959,GO:0070062" "cilium movement|ATP binding|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|inner dynein arm|dynein intermediate chain binding|dynein light intermediate chain binding|extracellular exosome" DNLZ 176.7522801 161.377999 192.1265612 1.190537511 0.251613077 0.659401324 1 2.639930989 3.278321842 728489 DNL-type zinc finger "GO:0005654,GO:0005739,GO:0006457,GO:0008270,GO:0030150,GO:0050821,GO:0051087" nucleoplasm|mitochondrion|protein folding|zinc ion binding|protein import into mitochondrial matrix|protein stabilization|chaperone binding DNM1 2639.50136 2659.184637 2619.818084 0.985196006 -0.021517316 0.947402584 1 33.35272928 34.27440708 1759 dynamin 1 "GO:0000266,GO:0003374,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005874,GO:0005886,GO:0006897,GO:0006898,GO:0007032,GO:0008017,GO:0014069,GO:0015630,GO:0016020,GO:0016185,GO:0019901,GO:0030424,GO:0031410,GO:0031623,GO:0031966,GO:0042802,GO:0044327,GO:0048013,GO:0048285,GO:0050803,GO:0061025,GO:0070062,GO:0098793,GO:0098844,GO:0098884" mitochondrial fission|dynamin family protein polymerization involved in mitochondrial fission|RNA binding|GTPase activity|protein binding|GTP binding|nucleoplasm|cytoplasm|microtubule|plasma membrane|endocytosis|receptor-mediated endocytosis|endosome organization|microtubule binding|postsynaptic density|microtubule cytoskeleton|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|protein kinase binding|axon|cytoplasmic vesicle|receptor internalization|mitochondrial membrane|identical protein binding|dendritic spine head|ephrin receptor signaling pathway|organelle fission|regulation of synapse structure or activity|membrane fusion|extracellular exosome|presynapse|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization "hsa04072,hsa04144,hsa04721,hsa04961,hsa05100" Phospholipase D signaling pathway|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Bacterial invasion of epithelial cells DNM1L 2627.101924 2586.107807 2668.09604 1.031703331 0.04502818 0.888735634 1 29.40005324 31.63871814 10059 dynamin 1 like "GO:0000139,GO:0000266,GO:0001836,GO:0003374,GO:0003924,GO:0005096,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005741,GO:0005777,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005874,GO:0005903,GO:0005905,GO:0006816,GO:0007005,GO:0007029,GO:0008017,GO:0008289,GO:0010468,GO:0010637,GO:0010821,GO:0016020,GO:0016559,GO:0030276,GO:0030672,GO:0030742,GO:0031267,GO:0031625,GO:0031966,GO:0032991,GO:0036466,GO:0042802,GO:0042803,GO:0043065,GO:0043231,GO:0043547,GO:0043653,GO:0044877,GO:0048285,GO:0048312,GO:0048471,GO:0048488,GO:0048511,GO:0050714,GO:0051259,GO:0051433,GO:0060047,GO:0061003,GO:0061025,GO:0065003,GO:0070266,GO:0070584,GO:0070585,GO:0090023,GO:0090141,GO:0090149,GO:0090200,GO:0090650,GO:0097194,GO:0098835,GO:0099073,GO:1900063,GO:1900244,GO:1903146,GO:1903578,GO:1904579,GO:1904666,GO:1905395,GO:1990910,GO:2000302,GO:2001244" Golgi membrane|mitochondrial fission|release of cytochrome c from mitochondria|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|GTPase activator activity|protein binding|GTP binding|cytoplasm|mitochondrion|mitochondrial outer membrane|peroxisome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|microtubule|brush border|clathrin-coated pit|calcium ion transport|mitochondrion organization|endoplasmic reticulum organization|microtubule binding|lipid binding|regulation of gene expression|negative regulation of mitochondrial fusion|regulation of mitochondrion organization|membrane|peroxisome fission|clathrin binding|synaptic vesicle membrane|GTP-dependent protein binding|small GTPase binding|ubiquitin protein ligase binding|mitochondrial membrane|protein-containing complex|synaptic vesicle recycling via endosome|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of GTPase activity|mitochondrial fragmentation involved in apoptotic process|protein-containing complex binding|organelle fission|intracellular distribution of mitochondria|perinuclear region of cytoplasm|synaptic vesicle endocytosis|rhythmic process|positive regulation of protein secretion|protein complex oligomerization|BH2 domain binding|heart contraction|positive regulation of dendritic spine morphogenesis|membrane fusion|protein-containing complex assembly|necroptotic process|mitochondrion morphogenesis|protein localization to mitochondrion|positive regulation of neutrophil chemotaxis|positive regulation of mitochondrial fission|mitochondrial membrane fission|positive regulation of release of cytochrome c from mitochondria|cellular response to oxygen-glucose deprivation|execution phase of apoptosis|presynaptic endocytic zone membrane|mitochondrion-derived vesicle|regulation of peroxisome organization|positive regulation of synaptic vesicle endocytosis|regulation of autophagy of mitochondrion|regulation of ATP metabolic process|cellular response to thapsigargin|regulation of ubiquitin protein ligase activity|response to flavonoid|response to hypobaric hypoxia|positive regulation of synaptic vesicle exocytosis|positive regulation of intrinsic apoptotic signaling pathway "hsa04217,hsa04621,hsa04668" Necroptosis|NOD-like receptor signaling pathway|TNF signaling pathway DNM2 3112.066292 3072.271716 3151.860869 1.025905636 0.036898036 0.908606108 1 41.25125241 44.14286166 1785 dynamin 2 "GO:0000086,GO:0000139,GO:0000266,GO:0001891,GO:0002031,GO:0003374,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0005813,GO:0005829,GO:0005874,GO:0005886,GO:0005905,GO:0005925,GO:0006355,GO:0006893,GO:0006897,GO:0006898,GO:0006909,GO:0007165,GO:0007283,GO:0008017,GO:0009416,GO:0010592,GO:0014069,GO:0015630,GO:0016020,GO:0016185,GO:0017124,GO:0019886,GO:0019899,GO:0019901,GO:0030027,GO:0030424,GO:0030426,GO:0030496,GO:0030512,GO:0030516,GO:0030666,GO:0030670,GO:0031410,GO:0031623,GO:0031749,GO:0031966,GO:0032587,GO:0032991,GO:0033572,GO:0035020,GO:0036312,GO:0042220,GO:0043065,GO:0044327,GO:0044351,GO:0044877,GO:0045211,GO:0045334,GO:0045429,GO:0045893,GO:0048285,GO:0048471,GO:0048489,GO:0048812,GO:0050699,GO:0050766,GO:0050803,GO:0050998,GO:0050999,GO:0061024,GO:0061025,GO:0070062,GO:0071245,GO:0071481,GO:0071732,GO:0098793,GO:0098844,GO:0098884,GO:0098978,GO:0099092,GO:1900026,GO:1902856,GO:1903351,GO:1903358,GO:1903408,GO:1903526,GO:2000370" "G2/M transition of mitotic cell cycle|Golgi membrane|mitochondrial fission|phagocytic cup|G protein-coupled receptor internalization|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|endosome|Golgi apparatus|trans-Golgi network|centrosome|cytosol|microtubule|plasma membrane|clathrin-coated pit|focal adhesion|regulation of transcription, DNA-templated|Golgi to plasma membrane transport|endocytosis|receptor-mediated endocytosis|phagocytosis|signal transduction|spermatogenesis|microtubule binding|response to light stimulus|positive regulation of lamellipodium assembly|postsynaptic density|microtubule cytoskeleton|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|SH3 domain binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|enzyme binding|protein kinase binding|lamellipodium|axon|growth cone|midbody|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of axon extension|endocytic vesicle membrane|phagocytic vesicle membrane|cytoplasmic vesicle|receptor internalization|D2 dopamine receptor binding|mitochondrial membrane|ruffle membrane|protein-containing complex|transferrin transport|regulation of Rac protein signal transduction|phosphatidylinositol 3-kinase regulatory subunit binding|response to cocaine|positive regulation of apoptotic process|dendritic spine head|macropinocytosis|protein-containing complex binding|postsynaptic membrane|clathrin-coated endocytic vesicle|positive regulation of nitric oxide biosynthetic process|positive regulation of transcription, DNA-templated|organelle fission|perinuclear region of cytoplasm|synaptic vesicle transport|neuron projection morphogenesis|WW domain binding|positive regulation of phagocytosis|regulation of synapse structure or activity|nitric-oxide synthase binding|regulation of nitric-oxide synthase activity|membrane organization|membrane fusion|extracellular exosome|cellular response to carbon monoxide|cellular response to X-ray|cellular response to nitric oxide|presynapse|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization|glutamatergic synapse|postsynaptic density, intracellular component|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of non-motile cilium assembly|cellular response to dopamine|regulation of Golgi organization|positive regulation of sodium:potassium-exchanging ATPase activity|negative regulation of membrane tubulation|positive regulation of clathrin-dependent endocytosis" "hsa04072,hsa04144,hsa04666,hsa04721,hsa04961,hsa05100,hsa05132" Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Bacterial invasion of epithelial cells|Salmonella infection DNM3 34.07797542 39.58328277 28.57266808 0.721836747 -0.470255505 0.636416315 1 0.162039576 0.122004546 26052 dynamin 3 "GO:0000266,GO:0003374,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0005874,GO:0005886,GO:0006897,GO:0007416,GO:0008017,GO:0014069,GO:0015630,GO:0016020,GO:0016185,GO:0030424,GO:0031410,GO:0031623,GO:0031798,GO:0031802,GO:0031966,GO:0043083,GO:0043197,GO:0044327,GO:0046847,GO:0048285,GO:0048471,GO:0050803,GO:0050998,GO:0051491,GO:0061002,GO:0061025,GO:0061828,GO:0061829,GO:0070062,GO:0098793,GO:0098844,GO:0098884,GO:0098978,GO:0099173,GO:0099186,GO:1903423" mitochondrial fission|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|protein binding|GTP binding|cytoplasm|Golgi apparatus|microtubule|plasma membrane|endocytosis|synapse assembly|microtubule binding|postsynaptic density|microtubule cytoskeleton|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|axon|cytoplasmic vesicle|receptor internalization|type 1 metabotropic glutamate receptor binding|type 5 metabotropic glutamate receptor binding|mitochondrial membrane|synaptic cleft|dendritic spine|dendritic spine head|filopodium assembly|organelle fission|perinuclear region of cytoplasm|regulation of synapse structure or activity|nitric-oxide synthase binding|positive regulation of filopodium assembly|negative regulation of dendritic spine morphogenesis|membrane fusion|apical tubulobulbar complex|basal tubulobulbar complex|extracellular exosome|presynapse|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization|glutamatergic synapse|postsynapse organization|structural constituent of postsynapse|positive regulation of synaptic vesicle recycling "hsa04072,hsa04144,hsa04721,hsa04961,hsa05100" Phospholipase D signaling pathway|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Bacterial invasion of epithelial cells DNMBP 3027.36745 2838.831844 3215.903056 1.132826188 0.179926522 0.571962874 1 18.06922434 21.35102455 23268 dynamin binding protein "GO:0005085,GO:0005515,GO:0005794,GO:0005795,GO:0005856,GO:0005911,GO:0007568,GO:0008360,GO:0035556,GO:0045202,GO:0050790,GO:0098793" guanyl-nucleotide exchange factor activity|protein binding|Golgi apparatus|Golgi stack|cytoskeleton|cell-cell junction|aging|regulation of cell shape|intracellular signal transduction|synapse|regulation of catalytic activity|presynapse DNMT1 3539.584204 3773.60629 3305.562118 0.875968997 -0.191048285 0.548381372 1 36.17638579 33.05444288 1786 DNA methyltransferase 1 "GO:0000122,GO:0003677,GO:0003886,GO:0005515,GO:0005634,GO:0005654,GO:0006306,GO:0006325,GO:0007265,GO:0008270,GO:0009008,GO:0010216,GO:0010628,GO:0010629,GO:0045814,GO:0051571,GO:0051573,GO:0090116,GO:0090309,GO:1904707,GO:1905460,GO:1905931,GO:1990841" "negative regulation of transcription by RNA polymerase II|DNA binding|DNA (cytosine-5-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|DNA methylation|chromatin organization|Ras protein signal transduction|zinc ion binding|DNA-methyltransferase activity|maintenance of DNA methylation|positive regulation of gene expression|negative regulation of gene expression|negative regulation of gene expression, epigenetic|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|C-5 methylation of cytosine|positive regulation of DNA methylation-dependent heterochromatin assembly|positive regulation of vascular associated smooth muscle cell proliferation|negative regulation of vascular associated smooth muscle cell apoptotic process|negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|promoter-specific chromatin binding" "hsa00270,hsa05206" Cysteine and methionine metabolism|MicroRNAs in cancer DNMT3A 281.585701 255.768904 307.402498 1.201875963 0.265288014 0.585506059 1 1.071181071 1.342883906 1788 DNA methyltransferase 3 alpha "GO:0000122,GO:0000278,GO:0000775,GO:0000791,GO:0000792,GO:0000978,GO:0001741,GO:0003677,GO:0003682,GO:0003714,GO:0003886,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006306,GO:0006346,GO:0006349,GO:0007283,GO:0007568,GO:0008134,GO:0009008,GO:0009636,GO:0010212,GO:0010288,GO:0010942,GO:0016363,GO:0030182,GO:0032355,GO:0033189,GO:0042220,GO:0042493,GO:0042802,GO:0043045,GO:0043046,GO:0045814,GO:0046872,GO:0071230,GO:0071361,GO:0071456,GO:0090116,GO:0097284" "negative regulation of transcription by RNA polymerase II|mitotic cell cycle|chromosome, centromeric region|euchromatin|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|XY body|DNA binding|chromatin binding|transcription corepressor activity|DNA (cytosine-5-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA methylation|DNA methylation-dependent heterochromatin assembly|regulation of gene expression by genetic imprinting|spermatogenesis|aging|transcription factor binding|DNA-methyltransferase activity|response to toxic substance|response to ionizing radiation|response to lead ion|positive regulation of cell death|nuclear matrix|neuron differentiation|response to estradiol|response to vitamin A|response to cocaine|response to drug|identical protein binding|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|negative regulation of gene expression, epigenetic|metal ion binding|cellular response to amino acid stimulus|cellular response to ethanol|cellular response to hypoxia|C-5 methylation of cytosine|hepatocyte apoptotic process" "hsa00270,hsa05206" Cysteine and methionine metabolism|MicroRNAs in cancer DNMT3B 378.3885488 340.0102494 416.7668482 1.225747897 0.293662287 0.506897217 1 3.719291501 4.75529325 1789 DNA methyltransferase 3 beta "GO:0000122,GO:0001666,GO:0003677,GO:0003682,GO:0003714,GO:0003886,GO:0005515,GO:0005634,GO:0005654,GO:0006306,GO:0009008,GO:0009636,GO:0010212,GO:0010628,GO:0014823,GO:0031000,GO:0032355,GO:0033189,GO:0042220,GO:0042493,GO:0042826,GO:0045666,GO:0045814,GO:0046872,GO:0051571,GO:0051573,GO:0071455,GO:0071549,GO:0090116" "negative regulation of transcription by RNA polymerase II|response to hypoxia|DNA binding|chromatin binding|transcription corepressor activity|DNA (cytosine-5-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|DNA methylation|DNA-methyltransferase activity|response to toxic substance|response to ionizing radiation|positive regulation of gene expression|response to activity|response to caffeine|response to estradiol|response to vitamin A|response to cocaine|response to drug|histone deacetylase binding|positive regulation of neuron differentiation|negative regulation of gene expression, epigenetic|metal ion binding|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|cellular response to hyperoxia|cellular response to dexamethasone stimulus|C-5 methylation of cytosine" "hsa00270,hsa05206" Cysteine and methionine metabolism|MicroRNAs in cancer DNPEP 669.4651521 638.4073041 700.5230002 1.097297909 0.133955261 0.727951581 1 7.475856136 8.556603675 23549 aspartyl aminopeptidase "GO:0004177,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0008237,GO:0008270,GO:0042802,GO:0072562" aminopeptidase activity|protein binding|nucleus|cytoplasm|cytosol|proteolysis|peptide metabolic process|metallopeptidase activity|zinc ion binding|identical protein binding|blood microparticle DNPH1 251.8765891 279.1128913 224.640287 0.804836659 -0.313232075 0.533705919 1 17.56035192 14.74201655 10591 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 "GO:0005515,GO:0005634,GO:0005829,GO:0006195,GO:0009116,GO:0009159,GO:0030307,GO:0030855,GO:0042802,GO:0042803,GO:0070062,GO:0070694" protein binding|nucleus|cytosol|purine nucleotide catabolic process|nucleoside metabolic process|deoxyribonucleoside monophosphate catabolic process|positive regulation of cell growth|epithelial cell differentiation|identical protein binding|protein homodimerization activity|extracellular exosome|deoxyribonucleoside 5'-monophosphate N-glycosidase activity DNTTIP1 2153.655402 2550.584349 1756.726455 0.688754503 -0.53793825 0.093990441 1 95.54593146 68.64241893 116092 deoxynucleotidyltransferase terminal interacting protein 1 "GO:0000118,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0031491,GO:0042803" histone deacetylase complex|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|nucleosome binding|protein homodimerization activity DNTTIP2 1259.189951 1382.370029 1136.009872 0.821784217 -0.283168472 0.404599538 1 11.87451921 10.17864014 30836 deoxynucleotidyltransferase terminal interacting protein 2 "GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730" RNA binding|protein binding|nucleoplasm|chromosome|nucleolus DOC2A 42.60118072 49.73284245 35.469519 0.713201121 -0.487619124 0.595341233 1 0.658163842 0.489623176 8448 double C2 domain alpha "GO:0005509,GO:0005515,GO:0005544,GO:0005654,GO:0005730,GO:0005764,GO:0007268,GO:0007399,GO:0016079,GO:0017158,GO:0030054,GO:0043005,GO:0061669,GO:0098850" calcium ion binding|protein binding|calcium-dependent phospholipid binding|nucleoplasm|nucleolus|lysosome|chemical synaptic transmission|nervous system development|synaptic vesicle exocytosis|regulation of calcium ion-dependent exocytosis|cell junction|neuron projection|spontaneous neurotransmitter secretion|extrinsic component of synaptic vesicle membrane DOCK1 2122.481009 1867.518982 2377.443037 1.273048928 0.348287868 0.278120813 1 7.890485377 10.47767069 1793 dedicator of cytokinesis 1 "GO:0005085,GO:0005096,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006911,GO:0006915,GO:0007165,GO:0007229,GO:0007264,GO:0007596,GO:0010634,GO:0016020,GO:0016607,GO:0017124,GO:0032045,GO:0038096,GO:0043547,GO:0048010,GO:1900026" "guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleoplasm|cytoplasm|cytosol|phagocytosis, engulfment|apoptotic process|signal transduction|integrin-mediated signaling pathway|small GTPase mediated signal transduction|blood coagulation|positive regulation of epithelial cell migration|membrane|nuclear speck|SH3 domain binding|guanyl-nucleotide exchange factor complex|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of GTPase activity|vascular endothelial growth factor receptor signaling pathway|positive regulation of substrate adhesion-dependent cell spreading" "hsa04510,hsa04666,hsa04810,hsa05100,hsa05131,hsa05135" Focal adhesion|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection DOCK10 161.6264178 205.0211056 118.23173 0.576680775 -0.794155168 0.170049404 1 1.030834481 0.620069457 55619 dedicator of cytokinesis 10 "GO:0001782,GO:0002315,GO:0003674,GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007264,GO:0016020,GO:0030334,GO:0043197,GO:0043547,GO:0060997,GO:0070062" B cell homeostasis|marginal zone B cell differentiation|molecular_function|guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|small GTPase mediated signal transduction|membrane|regulation of cell migration|dendritic spine|positive regulation of GTPase activity|dendritic spine morphogenesis|extracellular exosome DOCK11 776.6308437 690.1700585 863.0916289 1.250549221 0.322561842 0.383202023 1 4.766113811 6.217003737 139818 dedicator of cytokinesis 11 "GO:0001782,GO:0002315,GO:0005085,GO:0005515,GO:0005829,GO:0007264,GO:0007596,GO:0043547,GO:0051491" B cell homeostasis|marginal zone B cell differentiation|guanyl-nucleotide exchange factor activity|protein binding|cytosol|small GTPase mediated signal transduction|blood coagulation|positive regulation of GTPase activity|positive regulation of filopodium assembly DOCK2 11.40476967 5.074779842 17.7347595 3.494685494 1.805162625 0.190072376 1 0.019038496 0.069399552 1794 dedicator of cytokinesis 2 "GO:0001766,GO:0001768,GO:0001771,GO:0002277,GO:0005085,GO:0005096,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0006935,GO:0007264,GO:0016020,GO:0030036,GO:0035580,GO:0042608,GO:0043312,GO:0043547,GO:0044351,GO:0045059,GO:0045060,GO:0046633,GO:0050690,GO:0050766,GO:0070062" membrane raft polarization|establishment of T cell polarity|immunological synapse formation|myeloid dendritic cell activation involved in immune response|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|extracellular region|cytosol|cytoskeleton|chemotaxis|small GTPase mediated signal transduction|membrane|actin cytoskeleton organization|specific granule lumen|T cell receptor binding|neutrophil degranulation|positive regulation of GTPase activity|macropinocytosis|positive thymic T cell selection|negative thymic T cell selection|alpha-beta T cell proliferation|regulation of defense response to virus by virus|positive regulation of phagocytosis|extracellular exosome hsa04062 Chemokine signaling pathway DOCK3 8.478667972 7.104691779 9.852644165 1.386779958 0.471738892 0.817532793 1 0.022558308 0.032630972 1795 dedicator of cytokinesis 3 "GO:0005085,GO:0005515,GO:0005829,GO:0007264,GO:0017124,GO:1903997" guanyl-nucleotide exchange factor activity|protein binding|cytosol|small GTPase mediated signal transduction|SH3 domain binding|positive regulation of non-membrane spanning protein tyrosine kinase activity DOCK4 2129.528794 2214.633923 2044.423664 0.923142937 -0.115374046 0.720084773 1 11.94371158 11.50069771 9732 dedicator of cytokinesis 4 "GO:0005085,GO:0005096,GO:0005515,GO:0005730,GO:0005794,GO:0005829,GO:0005886,GO:0007264,GO:0016020,GO:0017124,GO:0030165,GO:0030971,GO:0031267,GO:0032420,GO:0032421,GO:0043547,GO:0060326,GO:1904694,GO:1904754" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleolus|Golgi apparatus|cytosol|plasma membrane|small GTPase mediated signal transduction|membrane|SH3 domain binding|PDZ domain binding|receptor tyrosine kinase binding|small GTPase binding|stereocilium|stereocilium bundle|positive regulation of GTPase activity|cell chemotaxis|negative regulation of vascular associated smooth muscle contraction|positive regulation of vascular associated smooth muscle cell migration hsa04015 Rap1 signaling pathway DOCK5 1267.568904 1146.900244 1388.237563 1.210425728 0.275514558 0.417014098 1 5.439825 6.868137869 80005 dedicator of cytokinesis 5 "GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007264,GO:0010634,GO:0016477,GO:0043547,GO:1900026,GO:1904694,GO:1904754" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|small GTPase mediated signal transduction|positive regulation of epithelial cell migration|cell migration|positive regulation of GTPase activity|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of vascular associated smooth muscle contraction|positive regulation of vascular associated smooth muscle cell migration DOCK6 622.6799381 639.4222601 605.9376162 0.947632971 -0.077599699 0.844928094 1 4.765226858 4.710203529 57572 dedicator of cytokinesis 6 "GO:0005085,GO:0005515,GO:0005829,GO:0007264,GO:0007596,GO:0048471,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|cytosol|small GTPase mediated signal transduction|blood coagulation|perinuclear region of cytoplasm|regulation of catalytic activity DOCK7 2324.446361 2405.445645 2243.447076 0.932653407 -0.100587049 0.753878796 1 14.07107138 13.68873692 85440 dedicator of cytokinesis 7 "GO:0000226,GO:0005085,GO:0005515,GO:0005925,GO:0007264,GO:0007409,GO:0008180,GO:0022027,GO:0030424,GO:0030426,GO:0031175,GO:0031267,GO:0033138,GO:0043005,GO:0045178,GO:0045200,GO:0050767,GO:0090630,GO:0120163,GO:1904754" microtubule cytoskeleton organization|guanyl-nucleotide exchange factor activity|protein binding|focal adhesion|small GTPase mediated signal transduction|axonogenesis|COP9 signalosome|interkinetic nuclear migration|axon|growth cone|neuron projection development|small GTPase binding|positive regulation of peptidyl-serine phosphorylation|neuron projection|basal part of cell|establishment of neuroblast polarity|regulation of neurogenesis|activation of GTPase activity|negative regulation of cold-induced thermogenesis|positive regulation of vascular associated smooth muscle cell migration DOCK8 14.46448335 12.17947162 16.74949508 1.375223458 0.459666059 0.748947294 1 0.075252808 0.107947332 81704 dedicator of cytokinesis 8 "GO:0001771,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0007264,GO:0007596,GO:0016020,GO:0031256,GO:0031258,GO:0036336,GO:0043547,GO:0061485,GO:0070233,GO:1903905,GO:1990869,GO:2000406" immunological synapse formation|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|small GTPase mediated signal transduction|blood coagulation|membrane|leading edge membrane|lamellipodium membrane|dendritic cell migration|positive regulation of GTPase activity|memory T cell proliferation|negative regulation of T cell apoptotic process|positive regulation of establishment of T cell polarity|cellular response to chemokine|positive regulation of T cell migration DOCK9 1746.004844 1691.931599 1800.078089 1.063918949 0.089388248 0.785164984 1 9.52326814 10.56843027 23348 dedicator of cytokinesis 9 "GO:0005085,GO:0005515,GO:0005829,GO:0007264,GO:0007596,GO:0008150,GO:0012505,GO:0016020,GO:0043547,GO:0045296" guanyl-nucleotide exchange factor activity|protein binding|cytosol|small GTPase mediated signal transduction|blood coagulation|biological_process|endomembrane system|membrane|positive regulation of GTPase activity|cadherin binding DOHH 240.0858293 247.6492563 232.5224023 0.938918234 -0.090928569 0.865412742 1 5.855537431 5.734696842 83475 deoxyhypusine hydroxylase "GO:0005506,GO:0005515,GO:0005575,GO:0005829,GO:0008612,GO:0016491,GO:0018215,GO:0019135,GO:0055114" iron ion binding|protein binding|cellular_component|cytosol|peptidyl-lysine modification to peptidyl-hypusine|oxidoreductase activity|protein phosphopantetheinylation|deoxyhypusine monooxygenase activity|oxidation-reduction process DOK1 474.5448634 481.089129 468.0005979 0.972793958 -0.039793827 0.92866146 1 9.805016983 9.94913089 1796 docking protein 1 "GO:0005515,GO:0005634,GO:0005829,GO:0007165,GO:0007166,GO:0007169,GO:0007265,GO:0007411,GO:0038145,GO:0045742,GO:0048471" protein binding|nucleus|cytosol|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|Ras protein signal transduction|axon guidance|macrophage colony-stimulating factor signaling pathway|positive regulation of epidermal growth factor receptor signaling pathway|perinuclear region of cytoplasm DOK3 96.7380215 147.1686154 46.30742758 0.31465559 -1.66815452 0.016988359 0.570200991 1.794311794 0.588910495 79930 docking protein 3 "GO:0005515,GO:0005886,GO:0030667,GO:0043312,GO:0101003" protein binding|plasma membrane|secretory granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane DOK4 292.654461 170.5126027 414.7963194 2.432643176 1.282524719 0.007821608 0.364181927 2.79477728 7.091556123 55715 docking protein 4 "GO:0005515,GO:0005829,GO:0007411" protein binding|cytosol|axon guidance DOLK 532.7118365 584.6146378 480.8090353 0.822437558 -0.282021945 0.484346847 1 14.27611813 12.2469797 22845 dolichol kinase "GO:0004168,GO:0005515,GO:0005789,GO:0006489,GO:0016310,GO:0030176,GO:0043048" dolichol kinase activity|protein binding|endoplasmic reticulum membrane|dolichyl diphosphate biosynthetic process|phosphorylation|integral component of endoplasmic reticulum membrane|dolichyl monophosphate biosynthetic process hsa00510 N-Glycan biosynthesis DOLPP1 706.2141295 692.1999704 720.2282885 1.040491649 0.057265386 0.882787138 1 16.16297214 17.54186453 57171 dolichyldiphosphatase 1 "GO:0005789,GO:0006487,GO:0006489,GO:0008610,GO:0030176,GO:0043231,GO:0047874" endoplasmic reticulum membrane|protein N-linked glycosylation|dolichyl diphosphate biosynthetic process|lipid biosynthetic process|integral component of endoplasmic reticulum membrane|intracellular membrane-bounded organelle|dolichyldiphosphatase activity hsa00510 N-Glycan biosynthesis DONSON 993.2445169 815.0096426 1171.479391 1.43738102 0.523442541 0.138183103 1 16.51094529 24.75482006 29980 DNA replication fork stabilization factor DONSON "GO:0000077,GO:0005515,GO:0005634,GO:0005657,GO:0006260,GO:0007095,GO:0007275,GO:0030894,GO:0033260,GO:0048478" DNA damage checkpoint|protein binding|nucleus|replication fork|DNA replication|mitotic G2 DNA damage checkpoint|multicellular organism development|replisome|nuclear DNA replication|replication fork protection DOP1A 312.8239278 336.9653815 288.682474 0.856712558 -0.223116858 0.636009308 1 1.728213451 1.544359642 23033 DOP1 leucine zipper like protein A "GO:0000139,GO:0005768,GO:0005802,GO:0005829,GO:0006895,GO:0015031" Golgi membrane|endosome|trans-Golgi network|cytosol|Golgi to endosome transport|protein transport DOP1B 288.5122435 257.798816 319.225671 1.238274388 0.308331035 0.521879024 1 1.67285081 2.160677904 9980 DOP1 leucine zipper like protein B "GO:0000139,GO:0003674,GO:0005768,GO:0005802,GO:0005829,GO:0006895,GO:0007029,GO:0007275,GO:0015031,GO:0050890,GO:0070062" Golgi membrane|molecular_function|endosome|trans-Golgi network|cytosol|Golgi to endosome transport|endoplasmic reticulum organization|multicellular organism development|protein transport|cognition|extracellular exosome DOT1L 913.0021285 852.5630134 973.4412435 1.141782165 0.191287433 0.594495991 1 4.308882244 5.131730141 84444 DOT1 like histone lysine methyltransferase "GO:0000077,GO:0000781,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006348,GO:0008284,GO:0010467,GO:0018024,GO:0031151,GO:0032200,GO:0032991,GO:0034729,GO:0042054,GO:0043231,GO:0045944,GO:0046425,GO:2000677" "DNA damage checkpoint|chromosome, telomeric region|DNA binding|protein binding|nucleus|nucleoplasm|DNA repair|chromatin silencing at telomere|positive regulation of cell population proliferation|gene expression|histone-lysine N-methyltransferase activity|histone methyltransferase activity (H3-K79 specific)|telomere organization|protein-containing complex|histone H3-K79 methylation|histone methyltransferase activity|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|regulation of receptor signaling pathway via JAK-STAT|regulation of transcription regulatory region DNA binding" "hsa00310,hsa05202" Lysine degradation|Transcriptional misregulation in cancer DPAGT1 1128.1337 1212.872382 1043.395017 0.860267768 -0.21714231 0.530254274 1 32.02695902 28.73857866 1798 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 "GO:0003975,GO:0003976,GO:0005515,GO:0005789,GO:0006047,GO:0006487,GO:0006488,GO:0006489,GO:0008963,GO:0016020,GO:0016021,GO:0016757,GO:0019348,GO:0030176,GO:0042802,GO:0043231,GO:0046872" "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|protein binding|endoplasmic reticulum membrane|UDP-N-acetylglucosamine metabolic process|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|dolichyl diphosphate biosynthetic process|phospho-N-acetylmuramoyl-pentapeptide-transferase activity|membrane|integral component of membrane|transferase activity, transferring glycosyl groups|dolichol metabolic process|integral component of endoplasmic reticulum membrane|identical protein binding|intracellular membrane-bounded organelle|metal ion binding" hsa00510 N-Glycan biosynthesis DPCD 769.1062647 883.0116925 655.200837 0.742006977 -0.430495342 0.245147774 1 19.0547197 14.74777434 25911 deleted in primary ciliary dyskinesia homolog (mouse) "GO:0003351,GO:0005515,GO:0005576,GO:0005634,GO:0007283,GO:0007368,GO:0021670,GO:0021678,GO:0030317,GO:0060972" epithelial cilium movement involved in extracellular fluid movement|protein binding|extracellular region|nucleus|spermatogenesis|determination of left/right symmetry|lateral ventricle development|third ventricle development|flagellated sperm motility|left/right pattern formation DPF1 109.8636634 101.4955968 118.23173 1.164895165 0.220200125 0.747191078 1 2.039838859 2.478555415 8193 double PHD fingers 1 "GO:0003712,GO:0005737,GO:0006915,GO:0007399,GO:0008270,GO:0042393,GO:0045892,GO:0045944,GO:0071565,GO:1990837" "transcription coregulator activity|cytoplasm|apoptotic process|nervous system development|zinc ion binding|histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|nBAF complex|sequence-specific double-stranded DNA binding" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma other DPF2 1482.619565 1400.639236 1564.599893 1.117061305 0.159708364 0.631367107 1 26.52858495 30.91057067 5977 double PHD fingers 2 "GO:0000122,GO:0000785,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006325,GO:0006915,GO:0007399,GO:0042393,GO:0043231,GO:0045892,GO:0045944,GO:0046872,GO:0062072,GO:0070577,GO:0071565,GO:0097190,GO:1905454" "negative regulation of transcription by RNA polymerase II|chromatin|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|centrosome|cytosol|chromatin organization|apoptotic process|nervous system development|histone binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|H3K9me3 modified histone binding|lysine-acetylated histone binding|nBAF complex|apoptotic signaling pathway|negative regulation of myeloid progenitor cell differentiation" DPF3 364.547588 370.4589285 358.6362476 0.968086393 -0.046792295 0.922606029 1 1.231858566 1.24391554 8110 double PHD fingers 3 "GO:0003712,GO:0005654,GO:0006325,GO:0007399,GO:0008150,GO:0008270,GO:0042393,GO:0045892,GO:0045944,GO:0071565" "transcription coregulator activity|nucleoplasm|chromatin organization|nervous system development|biological_process|zinc ion binding|histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma DPH1 454.0230574 425.2665507 482.7795641 1.135239918 0.182997224 0.665068354 1 8.015724058 9.491751104 1801 diphthamide biosynthesis 1 "GO:0005515,GO:0005654,GO:0005829,GO:0016740,GO:0017183,GO:0030054" protein binding|nucleoplasm|cytosol|transferase activity|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|cell junction DPH2 705.8523876 734.8281211 676.8766542 0.921136025 -0.11851388 0.75587357 1 14.6579173 14.0835443 1802 diphthamide biosynthesis 2 "GO:0005515,GO:0005829,GO:0017183,GO:0090560" protein binding|cytosol|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|2-(3-amino-3-carboxypropyl)histidine synthase activity DPH3 981.7370646 971.3128617 992.1612675 1.021464151 0.030638572 0.933901603 1 12.24025127 13.04155545 285381 diphthamide biosynthesis 3 "GO:0002098,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0017183,GO:0046872,GO:0050709,GO:0051099" tRNA wobble uridine modification|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|metal ion binding|negative regulation of protein secretion|positive regulation of binding DPH5 498.4017719 461.8049656 534.9985782 1.158494642 0.212251371 0.605910055 1 1.442328093 1.742906228 51611 diphthamide biosynthesis 5 "GO:0004164,GO:0005575,GO:0005829,GO:0017183,GO:0032259" diphthine synthase activity|cellular_component|cytosol|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|methylation DPH6 118.5501722 122.8096722 114.2906723 0.930632501 -0.103716523 0.883826938 1 0.623671578 0.605410708 89978 diphthamine biosynthesis 6 "GO:0005524,GO:0005654,GO:0005730,GO:0005829,GO:0017178,GO:0017183" ATP binding|nucleoplasm|nucleolus|cytosol|diphthine-ammonia ligase activity|peptidyl-diphthamide biosynthetic process from peptidyl-histidine DPH7 432.7507978 419.1768149 446.3247807 1.064764951 0.090534987 0.835705039 1 7.10978798 7.896348848 92715 diphthamide biosynthesis 7 "GO:0005515,GO:0017183,GO:0061685" protein binding|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|diphthine methylesterase activity DPM1 1542.742221 1503.149789 1582.334653 1.05267929 0.074065971 0.824191138 1 64.84602558 71.20252122 8813 "dolichyl-phosphate mannosyltransferase subunit 1, catalytic" "GO:0004169,GO:0004582,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0006506,GO:0016020,GO:0018279,GO:0019348,GO:0033185,GO:0035268,GO:0035269" dolichyl-phosphate-mannose-protein mannosyltransferase activity|dolichyl-phosphate beta-D-mannosyltransferase activity|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|membrane|protein N-linked glycosylation via asparagine|dolichol metabolic process|dolichol-phosphate-mannose synthase complex|protein mannosylation|protein O-linked mannosylation hsa00510 N-Glycan biosynthesis DPM2 1097.802549 991.6119811 1203.993117 1.214177662 0.279979537 0.420013245 1 35.71952251 45.23804342 8818 "dolichyl-phosphate mannosyltransferase subunit 2, regulatory" "GO:0000506,GO:0004582,GO:0005515,GO:0005789,GO:0006506,GO:0008047,GO:0016254,GO:0018279,GO:0019348,GO:0030176,GO:0030234,GO:0031647,GO:0033185,GO:0035269,GO:0050790" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|dolichyl-phosphate beta-D-mannosyltransferase activity|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|enzyme activator activity|preassembly of GPI anchor in ER membrane|protein N-linked glycosylation via asparagine|dolichol metabolic process|integral component of endoplasmic reticulum membrane|enzyme regulator activity|regulation of protein stability|dolichol-phosphate-mannose synthase complex|protein O-linked mannosylation|regulation of catalytic activity "hsa00510,hsa00563" N-Glycan biosynthesis|Glycosylphosphatidylinositol (GPI)-anchor biosynthesis DPM3 221.9772038 255.768904 188.1855036 0.735763811 -0.442685377 0.396867091 1 23.21468224 17.81628274 54344 "dolichyl-phosphate mannosyltransferase subunit 3, regulatory" "GO:0004582,GO:0005515,GO:0005783,GO:0005789,GO:0005975,GO:0006506,GO:0008047,GO:0016020,GO:0018279,GO:0018406,GO:0030176,GO:0031501,GO:0031647,GO:0033185,GO:0035268,GO:0035269,GO:0050790" dolichyl-phosphate beta-D-mannosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|carbohydrate metabolic process|GPI anchor biosynthetic process|enzyme activator activity|membrane|protein N-linked glycosylation via asparagine|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan|integral component of endoplasmic reticulum membrane|mannosyltransferase complex|regulation of protein stability|dolichol-phosphate-mannose synthase complex|protein mannosylation|protein O-linked mannosylation|regulation of catalytic activity hsa00510 N-Glycan biosynthesis DPP3 1030.504932 1004.806409 1056.203455 1.051151192 0.071970194 0.839685668 1 19.1315413 20.97640582 10072 dipeptidyl peptidase 3 "GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0008239,GO:0008270,GO:0070006,GO:0070062" protein binding|cytoplasm|cytosol|proteolysis|dipeptidyl-peptidase activity|zinc ion binding|metalloaminopeptidase activity|extracellular exosome DPP4 311.5296237 282.1577592 340.9014881 1.208194625 0.272852874 0.561927233 1 3.999522841 5.040353664 1803 dipeptidyl peptidase 4 "GO:0001618,GO:0001662,GO:0001666,GO:0002020,GO:0004177,GO:0004252,GO:0005102,GO:0005515,GO:0005576,GO:0005765,GO:0005886,GO:0005925,GO:0006508,GO:0007155,GO:0008236,GO:0008239,GO:0008284,GO:0009986,GO:0010716,GO:0016020,GO:0016021,GO:0016324,GO:0030027,GO:0030139,GO:0031258,GO:0031295,GO:0033632,GO:0035641,GO:0036343,GO:0042110,GO:0042802,GO:0042803,GO:0043542,GO:0045121,GO:0045499,GO:0046581,GO:0046718,GO:0050796,GO:0050919,GO:0070062,GO:0071438,GO:0090024" virus receptor activity|behavioral fear response|response to hypoxia|protease binding|aminopeptidase activity|serine-type endopeptidase activity|signaling receptor binding|protein binding|extracellular region|lysosomal membrane|plasma membrane|focal adhesion|proteolysis|cell adhesion|serine-type peptidase activity|dipeptidyl-peptidase activity|positive regulation of cell population proliferation|cell surface|negative regulation of extracellular matrix disassembly|membrane|integral component of membrane|apical plasma membrane|lamellipodium|endocytic vesicle|lamellipodium membrane|T cell costimulation|regulation of cell-cell adhesion mediated by integrin|locomotory exploration behavior|psychomotor behavior|T cell activation|identical protein binding|protein homodimerization activity|endothelial cell migration|membrane raft|chemorepellent activity|intercellular canaliculus|viral entry into host cell|regulation of insulin secretion|negative chemotaxis|extracellular exosome|invadopodium membrane|negative regulation of neutrophil chemotaxis hsa04974 Protein digestion and absorption DPP7 1377.950685 1485.895538 1270.005833 0.854707347 -0.226497571 0.499733409 1 45.0900941 40.19893141 29952 dipeptidyl peptidase 7 "GO:0004177,GO:0005576,GO:0005794,GO:0005829,GO:0006508,GO:0008236,GO:0008239,GO:0031982,GO:0035578,GO:0043231,GO:0043312,GO:0070062" aminopeptidase activity|extracellular region|Golgi apparatus|cytosol|proteolysis|serine-type peptidase activity|dipeptidyl-peptidase activity|vesicle|azurophil granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome DPP8 1240.31355 1102.242182 1378.384919 1.250528189 0.322537578 0.343472071 1 7.068204359 9.219736582 54878 dipeptidyl peptidase 8 "GO:0004177,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0006955,GO:0008236,GO:0008239" aminopeptidase activity|cytoplasm|cytosol|proteolysis|apoptotic process|immune response|serine-type peptidase activity|dipeptidyl-peptidase activity DPP9 2953.444411 2634.825694 3272.063127 1.241851837 0.312493058 0.326194677 1 23.19565901 30.04639895 91039 dipeptidyl peptidase 9 "GO:0004177,GO:0005634,GO:0005829,GO:0005874,GO:0006508,GO:0008236,GO:0008239,GO:0031252,GO:0042802" aminopeptidase activity|nucleus|cytosol|microtubule|proteolysis|serine-type peptidase activity|dipeptidyl-peptidase activity|cell leading edge|identical protein binding DPY19L1 1764.846356 1666.5577 1863.135012 1.117954099 0.160860955 0.62200065 1 16.11095023 18.78715672 23333 dpy-19 like C-mannosyltransferase 1 "GO:0000030,GO:0005637,GO:0016020,GO:0016021,GO:0018406" mannosyltransferase activity|nuclear inner membrane|membrane|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY19L2 64.81416742 52.77771036 76.85062449 1.456118956 0.542128219 0.493474968 1 0.357114875 0.542401305 283417 dpy-19 like 2 "GO:0000030,GO:0005634,GO:0005637,GO:0007275,GO:0007286,GO:0016021,GO:0018406" mannosyltransferase activity|nucleus|nuclear inner membrane|multicellular organism development|spermatid development|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY19L3 574.8918923 672.915807 476.8679776 0.7086592 -0.496836104 0.208503493 1 5.534396187 4.090944663 147991 dpy-19 like C-mannosyltransferase 3 "GO:0000030,GO:0005637,GO:0016021,GO:0018406" mannosyltransferase activity|nuclear inner membrane|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY19L4 1624.005009 1400.639236 1847.370781 1.31894833 0.399388047 0.224158697 1 15.19979348 20.91131765 286148 dpy-19 like 4 "GO:0000030,GO:0005637,GO:0016021,GO:0018406" mannosyltransferase activity|nuclear inner membrane|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY30 563.8745967 492.2536447 635.4955487 1.290992064 0.368480132 0.353470553 1 8.29371608 11.16834102 84661 dpy-30 histone methyltransferase complex regulatory subunit "GO:0000781,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005802,GO:0006348,GO:0016197,GO:0035097,GO:0042802,GO:0042803,GO:0044666,GO:0045652,GO:0048188,GO:0051568" "chromosome, telomeric region|protein binding|nucleus|nucleoplasm|Golgi apparatus|trans-Golgi network|chromatin silencing at telomere|endosomal transport|histone methyltransferase complex|identical protein binding|protein homodimerization activity|MLL3/4 complex|regulation of megakaryocyte differentiation|Set1C/COMPASS complex|histone H3-K4 methylation" DPYD 546.7066983 497.3284245 596.084972 1.198574106 0.261319112 0.51459029 1 2.972728695 3.716516764 1806 dihydropyrimidine dehydrogenase "GO:0002058,GO:0005515,GO:0005737,GO:0005829,GO:0006145,GO:0006208,GO:0006210,GO:0006212,GO:0006214,GO:0017113,GO:0019483,GO:0042803,GO:0046050,GO:0046079,GO:0046135,GO:0046872,GO:0050660,GO:0050661,GO:0051536,GO:0051539,GO:0055114" "uracil binding|protein binding|cytoplasm|cytosol|purine nucleobase catabolic process|pyrimidine nucleobase catabolic process|thymine catabolic process|uracil catabolic process|thymidine catabolic process|dihydropyrimidine dehydrogenase (NADP+) activity|beta-alanine biosynthetic process|protein homodimerization activity|UMP catabolic process|dUMP catabolic process|pyrimidine nucleoside catabolic process|metal ion binding|flavin adenine dinucleotide binding|NADP binding|iron-sulfur cluster binding|4 iron, 4 sulfur cluster binding|oxidation-reduction process" "hsa00240,hsa00410,hsa00770,hsa00983" Pyrimidine metabolism|beta-Alanine metabolism|Pantothenate and CoA biosynthesis|Drug metabolism - other enzymes DPYSL2 1385.577701 1502.134833 1269.020569 0.844811358 -0.243298864 0.468025571 1 14.41960388 12.70658962 1808 dihydropyrimidinase like 2 "GO:0004157,GO:0005515,GO:0005829,GO:0005874,GO:0005886,GO:0006139,GO:0006208,GO:0006897,GO:0007010,GO:0007165,GO:0007399,GO:0007411,GO:0007420,GO:0008017,GO:0016020,GO:0030516,GO:0042802,GO:0045664,GO:0070062" dihydropyrimidinase activity|protein binding|cytosol|microtubule|plasma membrane|nucleobase-containing compound metabolic process|pyrimidine nucleobase catabolic process|endocytosis|cytoskeleton organization|signal transduction|nervous system development|axon guidance|brain development|microtubule binding|membrane|regulation of axon extension|identical protein binding|regulation of neuron differentiation|extracellular exosome hsa04360 Axon guidance DPYSL3 2364.438398 2781.994309 1946.882487 0.69981541 -0.514953662 0.107462265 1 23.38559294 17.07056191 1809 dihydropyrimidinase like 3 "GO:0004157,GO:0005515,GO:0005615,GO:0005829,GO:0006208,GO:0010976,GO:0010977,GO:0017124,GO:0030027,GO:0030336,GO:0030426,GO:0031005,GO:0031941,GO:0035374,GO:0042802,GO:0044297,GO:0045202,GO:0048666,GO:0048678,GO:0051017,GO:0051491,GO:0051764,GO:0070382,GO:0071345" dihydropyrimidinase activity|protein binding|extracellular space|cytosol|pyrimidine nucleobase catabolic process|positive regulation of neuron projection development|negative regulation of neuron projection development|SH3 domain binding|lamellipodium|negative regulation of cell migration|growth cone|filamin binding|filamentous actin|chondroitin sulfate binding|identical protein binding|cell body|synapse|neuron development|response to axon injury|actin filament bundle assembly|positive regulation of filopodium assembly|actin crosslink formation|exocytic vesicle|cellular response to cytokine stimulus DQX1 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.100673598 0.020387647 165545 DEAQ-box RNA dependent ATPase 1 "GO:0003678,GO:0003723,GO:0005524,GO:0005622,GO:0005681,GO:0032508" DNA helicase activity|RNA binding|ATP binding|intracellular anatomical structure|spliceosomal complex|DNA duplex unwinding DR1 1548.270539 1443.267387 1653.273691 1.145507552 0.19598697 0.553468325 1 7.220110787 8.626959275 1810 down-regulator of transcription 1 "GO:0000122,GO:0001046,GO:0003713,GO:0003714,GO:0005515,GO:0005654,GO:0005671,GO:0006338,GO:0016251,GO:0017025,GO:0017054,GO:0043966,GO:0045944,GO:0046982,GO:0051123,GO:0090575" negative regulation of transcription by RNA polymerase II|core promoter sequence-specific DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|negative cofactor 2 complex|histone H3 acetylation|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|RNA polymerase II preinitiation complex assembly|RNA polymerase II transcription regulator complex DRAM1 1098.467887 1070.778547 1126.157228 1.051718146 0.072748123 0.836080857 1 14.84158618 16.28154505 55332 DNA damage regulated autophagy modulator 1 "GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0006914,GO:0006915,GO:0010506,GO:0016021" protein binding|cytoplasm|lysosome|lysosomal membrane|autophagy|apoptotic process|regulation of autophagy|integral component of membrane DRAM2 742.1965696 626.2278325 858.1653068 1.370372351 0.454567948 0.223201115 1 13.82573257 19.76253578 128338 DNA damage regulated autophagy modulator 2 "GO:0001917,GO:0005737,GO:0005764,GO:0005765,GO:0005794,GO:0006914,GO:0006915,GO:0007601,GO:0010506,GO:0016021,GO:0016324,GO:0043231,GO:0045494" photoreceptor inner segment|cytoplasm|lysosome|lysosomal membrane|Golgi apparatus|autophagy|apoptotic process|visual perception|regulation of autophagy|integral component of membrane|apical plasma membrane|intracellular membrane-bounded organelle|photoreceptor cell maintenance DRAP1 4396.087776 4198.872841 4593.30271 1.093937084 0.129529766 0.685475523 1 258.7081468 295.2013774 10589 DR1 associated protein 1 "GO:0000122,GO:0001046,GO:0001091,GO:0003677,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0006355,GO:0006366,GO:0016251,GO:0017025,GO:0017054,GO:0042802,GO:0045944,GO:0046982,GO:0090575" "negative regulation of transcription by RNA polymerase II|core promoter sequence-specific DNA binding|RNA polymerase II general transcription initiation factor binding|DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|regulation of transcription, DNA-templated|transcription by RNA polymerase II|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|negative cofactor 2 complex|identical protein binding|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|RNA polymerase II transcription regulator complex" NF-YB/C DRC3 12.06070541 16.23929549 7.882115332 0.485372985 -1.042834281 0.44253226 1 0.195917825 0.09918945 83450 dynein regulatory complex subunit 3 "GO:0005515,GO:0005737,GO:0005930,GO:0031514" protein binding|cytoplasm|axoneme|motile cilium DRG1 1321.706982 1412.818708 1230.595256 0.871021349 -0.199220015 0.555308371 1 42.97554561 39.04506305 4733 developmentally regulated GTP binding protein 1 "GO:0002181,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006351,GO:0007275,GO:0008017,GO:0008134,GO:0016020,GO:0016604,GO:0030955,GO:0031116,GO:0042802,GO:1901673" "cytoplasmic translation|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|polysome|transcription, DNA-templated|multicellular organism development|microtubule binding|transcription factor binding|membrane|nuclear body|potassium ion binding|positive regulation of microtubule polymerization|identical protein binding|regulation of mitotic spindle assembly" DRG2 755.9172804 789.6357434 722.1988173 0.914597425 -0.128791238 0.731219347 1 19.57526419 18.67469579 1819 developmentally regulated GTP binding protein 2 "GO:0002181,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0016020,GO:0043231,GO:0046872" cytoplasmic translation|RNA binding|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|membrane|intracellular membrane-bounded organelle|metal ion binding DROSHA 2314.816649 2050.211056 2579.422243 1.258125223 0.331275523 0.300309227 1 16.79378251 22.03881928 29102 drosha ribonuclease III "GO:0001530,GO:0003723,GO:0003725,GO:0004525,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006396,GO:0010586,GO:0010628,GO:0014069,GO:0016075,GO:0017151,GO:0030422,GO:0031053,GO:0031054,GO:0042254,GO:0042803,GO:0045589,GO:0046332,GO:0046872,GO:0050727,GO:0050829,GO:0050830,GO:0070412,GO:0070877,GO:0070878,GO:0090502,GO:2000628" "lipopolysaccharide binding|RNA binding|double-stranded RNA binding|ribonuclease III activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|RNA processing|miRNA metabolic process|positive regulation of gene expression|postsynaptic density|rRNA catabolic process|DEAD/H-box RNA helicase binding|production of siRNA involved in RNA interference|primary miRNA processing|pre-miRNA processing|ribosome biogenesis|protein homodimerization activity|regulation of regulatory T cell differentiation|SMAD binding|metal ion binding|regulation of inflammatory response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|R-SMAD binding|microprocessor complex|primary miRNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic|regulation of miRNA metabolic process" "hsa03008,hsa05205" Ribosome biogenesis in eukaryotes|Proteoglycans in cancer DRP2 9.49362394 9.134603715 9.852644165 1.078606634 0.109168812 1 1 0.063575024 0.071526266 1821 dystrophin related protein 2 "GO:0005886,GO:0007417,GO:0008270,GO:0014069,GO:0030425,GO:0043204,GO:0050808,GO:0098978,GO:0099536" plasma membrane|central nervous system development|zinc ion binding|postsynaptic density|dendrite|perikaryon|synapse organization|glutamatergic synapse|synaptic signaling DSC2 600.0270214 538.9416192 661.1124235 1.226686528 0.294766624 0.451753686 1 2.199830089 2.814742452 1824 desmocollin 2 "GO:0001533,GO:0005509,GO:0005515,GO:0005886,GO:0005911,GO:0005912,GO:0007155,GO:0007156,GO:0009267,GO:0014704,GO:0016021,GO:0030057,GO:0031410,GO:0031424,GO:0070062,GO:0070268,GO:0086042,GO:0086073,GO:0086083,GO:0086091,GO:0098609,GO:0098911" cornified envelope|calcium ion binding|protein binding|plasma membrane|cell-cell junction|adherens junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cellular response to starvation|intercalated disc|integral component of membrane|desmosome|cytoplasmic vesicle|keratinization|extracellular exosome|cornification|cardiac muscle cell-cardiac muscle cell adhesion|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential hsa05412 Arrhythmogenic right ventricular cardiomyopathy DSC3 2040.880974 1711.215763 2370.546186 1.38529941 0.470197825 0.144322537 1 11.36467894 16.42164842 1825 desmocollin 3 "GO:0001533,GO:0001701,GO:0005509,GO:0005576,GO:0005737,GO:0005886,GO:0005911,GO:0007155,GO:0007156,GO:0016020,GO:0016021,GO:0030054,GO:0030057,GO:0031424,GO:0045295,GO:0070268,GO:0098609" cornified envelope|in utero embryonic development|calcium ion binding|extracellular region|cytoplasm|plasma membrane|cell-cell junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|membrane|integral component of membrane|cell junction|desmosome|keratinization|gamma-catenin binding|cornification|cell-cell adhesion DSCC1 418.0339363 389.7430919 446.3247807 1.145176887 0.195570458 0.650891388 1 8.915588379 10.64972794 79075 DNA replication and sister chromatid cohesion 1 "GO:0000775,GO:0000785,GO:0003689,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006275,GO:0017116,GO:0031390,GO:0032508,GO:0034088,GO:0034421,GO:1900264" "chromosome, centromeric region|chromatin|DNA clamp loader activity|protein binding|nucleus|nucleoplasm|DNA replication|regulation of DNA replication|single-stranded DNA helicase activity|Ctf18 RFC-like complex|DNA duplex unwinding|maintenance of mitotic sister chromatid cohesion|post-translational protein acetylation|positive regulation of DNA-directed DNA polymerase activity" DSE 1752.983843 1966.984667 1538.983019 0.782407227 -0.354008399 0.277397416 1 16.22753449 13.24345573 29940 dermatan sulfate epimerase "GO:0000139,GO:0005783,GO:0005794,GO:0015012,GO:0016021,GO:0030204,GO:0030205,GO:0030206,GO:0030208,GO:0047757" Golgi membrane|endoplasmic reticulum|Golgi apparatus|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|chondroitin sulfate metabolic process|dermatan sulfate metabolic process|chondroitin sulfate biosynthetic process|dermatan sulfate biosynthetic process|chondroitin-glucuronate 5-epimerase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate DSEL 309.1231241 319.71113 298.5351182 0.933765172 -0.098868316 0.838816269 1 1.747489841 1.702034114 92126 dermatan sulfate epimerase like "GO:0000139,GO:0008146,GO:0016021,GO:0030204,GO:0030205,GO:0030208,GO:0047757" Golgi membrane|sulfotransferase activity|integral component of membrane|chondroitin sulfate metabolic process|dermatan sulfate metabolic process|dermatan sulfate biosynthetic process|chondroitin-glucuronate 5-epimerase activity DSG2 5706.934331 4970.239377 6443.629284 1.296442444 0.374558158 0.247093612 1 59.55171292 80.53106237 1829 desmoglein 2 "GO:0001533,GO:0002934,GO:0003165,GO:0005509,GO:0005886,GO:0005911,GO:0007155,GO:0007156,GO:0009986,GO:0014704,GO:0016021,GO:0016324,GO:0016328,GO:0030054,GO:0030057,GO:0031424,GO:0032570,GO:0043231,GO:0050839,GO:0060135,GO:0070062,GO:0070268,GO:0086073,GO:0086083,GO:0086091,GO:0098609,GO:0098911" cornified envelope|desmosome organization|Purkinje myocyte development|calcium ion binding|plasma membrane|cell-cell junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell surface|intercalated disc|integral component of membrane|apical plasma membrane|lateral plasma membrane|cell junction|desmosome|keratinization|response to progesterone|intracellular membrane-bounded organelle|cell adhesion molecule binding|maternal process involved in female pregnancy|extracellular exosome|cornification|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential hsa05412 Arrhythmogenic right ventricular cardiomyopathy DSN1 1443.828551 1308.278243 1579.37886 1.207219388 0.271687881 0.415042302 1 26.93482833 33.91691501 79980 DSN1 component of MIS12 kinetochore complex "GO:0000070,GO:0000444,GO:0000776,GO:0000777,GO:0000818,GO:0000941,GO:0001650,GO:0005515,GO:0005576,GO:0005654,GO:0005730,GO:0005829,GO:0016604,GO:0035578,GO:0043312,GO:0051301" mitotic sister chromatid segregation|MIS12/MIND type complex|kinetochore|condensed chromosome kinetochore|nuclear MIS12/MIND complex|condensed nuclear chromosome inner kinetochore|fibrillar center|protein binding|extracellular region|nucleoplasm|nucleolus|cytosol|nuclear body|azurophil granule lumen|neutrophil degranulation|cell division DSP 2506.843003 2548.554437 2465.13157 0.967266594 -0.04801452 0.881488172 1 16.33864449 16.4845897 1832 desmoplakin "GO:0001533,GO:0002934,GO:0003223,GO:0003723,GO:0005080,GO:0005198,GO:0005200,GO:0005515,GO:0005634,GO:0005737,GO:0005882,GO:0005886,GO:0005916,GO:0008544,GO:0014704,GO:0016020,GO:0016323,GO:0018149,GO:0030057,GO:0030216,GO:0031424,GO:0034332,GO:0042060,GO:0043312,GO:0043588,GO:0045104,GO:0045109,GO:0070062,GO:0070268,GO:0086073,GO:0086083,GO:0086091,GO:0090136,GO:0097110,GO:0098609,GO:0098911,GO:0101003,GO:0150105" cornified envelope|desmosome organization|ventricular compact myocardium morphogenesis|RNA binding|protein kinase C binding|structural molecule activity|structural constituent of cytoskeleton|protein binding|nucleus|cytoplasm|intermediate filament|plasma membrane|fascia adherens|epidermis development|intercalated disc|membrane|basolateral plasma membrane|peptide cross-linking|desmosome|keratinocyte differentiation|keratinization|adherens junction organization|wound healing|neutrophil degranulation|skin development|intermediate filament cytoskeleton organization|intermediate filament organization|extracellular exosome|cornification|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|epithelial cell-cell adhesion|scaffold protein binding|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential|ficolin-1-rich granule membrane|protein localization to cell-cell junction hsa05412 Arrhythmogenic right ventricular cardiomyopathy DST 4034.529878 3594.97404 4474.085716 1.244539089 0.315611543 0.322310693 1 5.556249895 7.212839052 667 dystonin "GO:0003779,GO:0005178,GO:0005198,GO:0005509,GO:0005515,GO:0005604,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0005882,GO:0005925,GO:0005938,GO:0007010,GO:0007155,GO:0007229,GO:0008017,GO:0008022,GO:0008090,GO:0009611,GO:0009925,GO:0015630,GO:0016020,GO:0016021,GO:0030011,GO:0030018,GO:0030056,GO:0031122,GO:0031252,GO:0031410,GO:0031581,GO:0031673,GO:0035371,GO:0042060,GO:0045104,GO:0048870,GO:0051010,GO:1904115" actin binding|integrin binding|structural molecule activity|calcium ion binding|protein binding|basement membrane|nucleus|nuclear envelope|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|intermediate filament|focal adhesion|cell cortex|cytoskeleton organization|cell adhesion|integrin-mediated signaling pathway|microtubule binding|protein C-terminus binding|retrograde axonal transport|response to wounding|basal plasma membrane|microtubule cytoskeleton|membrane|integral component of membrane|maintenance of cell polarity|Z disc|hemidesmosome|cytoplasmic microtubule organization|cell leading edge|cytoplasmic vesicle|hemidesmosome assembly|H zone|microtubule plus-end|wound healing|intermediate filament cytoskeleton organization|cell motility|microtubule plus-end binding|axon cytoplasm DSTN 5196.459237 5198.60447 5194.314004 0.999174689 -0.001191164 0.997730614 1 67.23467233 70.07298955 11034 "destrin, actin depolymerizing factor" "GO:0005515,GO:0005737,GO:0008154,GO:0015629,GO:0030042,GO:0030043,GO:0030836,GO:0030864,GO:0048870,GO:0051014,GO:0051015,GO:0070062" protein binding|cytoplasm|actin polymerization or depolymerization|actin cytoskeleton|actin filament depolymerization|actin filament fragmentation|positive regulation of actin filament depolymerization|cortical actin cytoskeleton|cell motility|actin filament severing|actin filament binding|extracellular exosome DSTYK 1269.732428 1160.094672 1379.370183 1.189015187 0.249767142 0.461883646 1 7.277926739 9.026325925 25778 dual serine/threonine and tyrosine protein kinase "GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005737,GO:0016323,GO:0016324,GO:0018108,GO:0030054,GO:0033674,GO:0043066,GO:0044344,GO:0045743,GO:0070374" protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|cytoplasm|basolateral plasma membrane|apical plasma membrane|peptidyl-tyrosine phosphorylation|cell junction|positive regulation of kinase activity|negative regulation of apoptotic process|cellular response to fibroblast growth factor stimulus|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade DTD1 1546.553626 1629.004329 1464.102923 0.898771659 -0.153973463 0.641957996 1 19.28999824 18.08412445 92675 D-aminoacyl-tRNA deacylase 1 "GO:0000049,GO:0003677,GO:0005634,GO:0005737,GO:0006260,GO:0006399,GO:0046872,GO:0051500,GO:0106074" tRNA binding|DNA binding|nucleus|cytoplasm|DNA replication|tRNA metabolic process|metal ion binding|D-tyrosyl-tRNA(Tyr) deacylase activity|aminoacyl-tRNA metabolism involved in translational fidelity DTD2 188.3918606 216.1856213 160.5980999 0.74287133 -0.428815747 0.43719602 1 4.035768175 3.127200584 112487 D-aminoacyl-tRNA deacylase 2 "GO:0000049,GO:0005515,GO:0005737,GO:0006399,GO:0051500,GO:0106074,GO:0106105" tRNA binding|protein binding|cytoplasm|tRNA metabolic process|D-tyrosyl-tRNA(Tyr) deacylase activity|aminoacyl-tRNA metabolism involved in translational fidelity|Ala-tRNA(Thr) hydrolase activity DTL 1268.3248 1030.180308 1506.469293 1.462335556 0.548274398 0.106398075 1 12.0357551 18.3584627 51514 denticleless E3 ubiquitin protein ligase homolog "GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005813,GO:0005829,GO:0006260,GO:0006511,GO:0006513,GO:0006974,GO:0009411,GO:0010971,GO:0019985,GO:0031464,GO:0031465,GO:0031965,GO:0042769,GO:0043687,GO:0045732,GO:0048511,GO:0051726,GO:0072425,GO:0080008" "protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|centrosome|cytosol|DNA replication|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|response to UV|positive regulation of G2/M transition of mitotic cell cycle|translesion synthesis|Cul4A-RING E3 ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|nuclear membrane|DNA damage response, detection of DNA damage|post-translational protein modification|positive regulation of protein catabolic process|rhythmic process|regulation of cell cycle|signal transduction involved in G2 DNA damage checkpoint|Cul4-RING E3 ubiquitin ligase complex" DTNA 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.014462329 0.009762668 1837 dystrobrevin alpha "GO:0005515,GO:0005654,GO:0005737,GO:0005886,GO:0006941,GO:0007165,GO:0007268,GO:0007274,GO:0008270,GO:0030054,GO:0032991,GO:0045111,GO:0045202,GO:0099536" protein binding|nucleoplasm|cytoplasm|plasma membrane|striated muscle contraction|signal transduction|chemical synaptic transmission|neuromuscular synaptic transmission|zinc ion binding|cell junction|protein-containing complex|intermediate filament cytoskeleton|synapse|synaptic signaling DTNB 200.2892625 221.2604011 179.3181238 0.810439296 -0.303223966 0.577259878 1 1.395002957 1.17926538 1838 dystrobrevin beta "GO:0005515,GO:0005737,GO:0005886,GO:0008270,GO:0045202,GO:0099536" protein binding|cytoplasm|plasma membrane|zinc ion binding|synapse|synaptic signaling DTNBP1 221.876005 215.1706653 228.5813446 1.062325779 0.087226259 0.875143542 1 3.23371962 3.583240944 84062 dystrobrevin binding protein 1 "GO:0001956,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0006469,GO:0007596,GO:0008089,GO:0010008,GO:0010628,GO:0014059,GO:0014069,GO:0015630,GO:0016528,GO:0030424,GO:0030426,GO:0030496,GO:0030672,GO:0031083,GO:0031175,GO:0031532,GO:0032091,GO:0032438,GO:0033162,GO:0042383,GO:0043005,GO:0043197,GO:0043506,GO:0045211,GO:0048490,GO:0048812,GO:0048813,GO:0060155,GO:0060159,GO:0071901,GO:0098685,GO:0098686,GO:0098978,GO:1904115,GO:2000300" positive regulation of neurotransmitter secretion|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|negative regulation of protein kinase activity|blood coagulation|anterograde axonal transport|endosome membrane|positive regulation of gene expression|regulation of dopamine secretion|postsynaptic density|microtubule cytoskeleton|sarcoplasm|axon|growth cone|midbody|synaptic vesicle membrane|BLOC-1 complex|neuron projection development|actin cytoskeleton reorganization|negative regulation of protein binding|melanosome organization|melanosome membrane|sarcolemma|neuron projection|dendritic spine|regulation of JUN kinase activity|postsynaptic membrane|anterograde synaptic vesicle transport|neuron projection morphogenesis|dendrite morphogenesis|platelet dense granule organization|regulation of dopamine receptor signaling pathway|negative regulation of protein serine/threonine kinase activity|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|axon cytoplasm|regulation of synaptic vesicle exocytosis DTWD1 230.8176136 220.2454451 241.3897821 1.096003515 0.132252425 0.803895751 1 1.138230083 1.301241593 56986 DTW domain containing 1 "GO:0005634,GO:0006400,GO:0016432" nucleus|tRNA modification|tRNA-uridine aminocarboxypropyltransferase activity DTWD2 196.2118712 245.6193443 146.8043981 0.597690701 -0.742528998 0.171479997 1 2.099536422 1.308928252 285605 DTW domain containing 2 "GO:0005634,GO:0005737,GO:0006400,GO:0016432" nucleus|cytoplasm|tRNA modification|tRNA-uridine aminocarboxypropyltransferase activity DTX2 396.2096614 379.5935322 412.8257905 1.087546956 0.121077693 0.785120755 1 4.153180661 4.711343507 113878 deltex E3 ubiquitin ligase 2 "GO:0005515,GO:0005654,GO:0005737,GO:0007219,GO:0008270,GO:0016567,GO:0031965,GO:0061630" protein binding|nucleoplasm|cytoplasm|Notch signaling pathway|zinc ion binding|protein ubiquitination|nuclear membrane|ubiquitin protein ligase activity hsa04330 Notch signaling pathway DTX3 493.988371 395.8328277 592.1439143 1.495944431 0.581056586 0.156589332 1 6.302274853 9.833966642 196403 deltex E3 ubiquitin ligase 3 "GO:0005515,GO:0005654,GO:0005737,GO:0007219,GO:0016567,GO:0046872,GO:0061630" protein binding|nucleoplasm|cytoplasm|Notch signaling pathway|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity hsa04330 Notch signaling pathway DTX3L 995.2811098 920.5650633 1069.997156 1.162326487 0.217015366 0.539189019 1 8.083109032 9.799919346 151636 deltex E3 ubiquitin ligase 3L "GO:0000209,GO:0002230,GO:0004842,GO:0004857,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005765,GO:0005769,GO:0005829,GO:0006302,GO:0006511,GO:0006974,GO:0007219,GO:0008047,GO:0008333,GO:0010390,GO:0015031,GO:0016032,GO:0016567,GO:0019899,GO:0031901,GO:0032092,GO:0032991,GO:0033522,GO:0033523,GO:0035563,GO:0042393,GO:0044389,GO:0045087,GO:0045893,GO:0046872,GO:0051444,GO:0051607,GO:0051865,GO:0061630,GO:0070936,GO:0097677,GO:1900182,GO:1901666,GO:1902966,GO:2000646,GO:2001034" "protein polyubiquitination|positive regulation of defense response to virus by host|ubiquitin-protein transferase activity|enzyme inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|lysosome|lysosomal membrane|early endosome|cytosol|double-strand break repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|Notch signaling pathway|enzyme activator activity|endosome to lysosome transport|histone monoubiquitination|protein transport|viral process|protein ubiquitination|enzyme binding|early endosome membrane|positive regulation of protein binding|protein-containing complex|histone H2A ubiquitination|histone H2B ubiquitination|positive regulation of chromatin binding|histone binding|ubiquitin-like protein ligase binding|innate immune response|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of ubiquitin-protein transferase activity|defense response to virus|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination|STAT family protein binding|positive regulation of protein localization to nucleus|positive regulation of NAD+ ADP-ribosyltransferase activity|positive regulation of protein localization to early endosome|positive regulation of receptor catabolic process|positive regulation of double-strand break repair via nonhomologous end joining" hsa04330 Notch signaling pathway DTX4 360.7913607 484.1339969 237.4487244 0.490460752 -1.027790401 0.022220883 0.64869087 3.979821299 2.036028072 23220 deltex E3 ubiquitin ligase 4 "GO:0004842,GO:0005654,GO:0005829,GO:0007219,GO:0008270,GO:0016567,GO:0032479,GO:0061630" ubiquitin-protein transferase activity|nucleoplasm|cytosol|Notch signaling pathway|zinc ion binding|protein ubiquitination|regulation of type I interferon production|ubiquitin protein ligase activity hsa04330 Notch signaling pathway DTYMK 827.3368264 755.1272405 899.5464123 1.19125144 0.252477958 0.489837011 1 31.81741331 39.53522709 1841 deoxythymidylate kinase "GO:0004550,GO:0004798,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005758,GO:0005759,GO:0005829,GO:0006165,GO:0006227,GO:0006233,GO:0006235,GO:0009041,GO:0015949,GO:0043627,GO:0045445,GO:0046105,GO:0046686,GO:0046940,GO:0071363" nucleoside diphosphate kinase activity|thymidylate kinase activity|ATP binding|nucleus|cytoplasm|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|cytosol|nucleoside diphosphate phosphorylation|dUDP biosynthetic process|dTDP biosynthetic process|dTTP biosynthetic process|uridylate kinase activity|nucleobase-containing small molecule interconversion|response to estrogen|myoblast differentiation|thymidine biosynthetic process|response to cadmium ion|nucleoside monophosphate phosphorylation|cellular response to growth factor stimulus hsa00240 Pyrimidine metabolism DUS1L 959.6631331 910.4155036 1008.910763 1.10818715 0.148201544 0.677867931 1 20.06498412 23.19358383 64118 dihydrouridine synthase 1 like "GO:0002943,GO:0005515,GO:0017150,GO:0050660,GO:0055114" tRNA dihydrouridine synthesis|protein binding|tRNA dihydrouridine synthase activity|flavin adenine dinucleotide binding|oxidation-reduction process DUS2 238.8778782 232.4249168 245.3308397 1.055527278 0.077963863 0.886048505 1 5.939203879 6.539034442 54920 dihydrouridine synthase 2 "GO:0002943,GO:0003725,GO:0004860,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0006469,GO:0010181,GO:0017150,GO:0050660,GO:0055114,GO:0060548,GO:0070402,GO:0102264" tRNA dihydrouridine synthesis|double-stranded RNA binding|protein kinase inhibitor activity|protein binding|cytoplasm|endoplasmic reticulum|cytosol|negative regulation of protein kinase activity|FMN binding|tRNA dihydrouridine synthase activity|flavin adenine dinucleotide binding|oxidation-reduction process|negative regulation of cell death|NADPH binding|tRNA-dihydrouridine20 synthase activity DUS3L 307.8827599 335.9504255 279.8150943 0.832905908 -0.263774569 0.576612383 1 8.332372131 7.239032563 56931 dihydrouridine synthase 3 like "GO:0002943,GO:0003723,GO:0005515,GO:0017150,GO:0046872,GO:0050660,GO:0055114" tRNA dihydrouridine synthesis|RNA binding|protein binding|tRNA dihydrouridine synthase activity|metal ion binding|flavin adenine dinucleotide binding|oxidation-reduction process DUS4L 65.9478896 62.92727004 68.96850916 1.096003515 0.132252425 0.883289477 1 1.506164572 1.721869782 11062 dihydrouridine synthase 4 like "GO:0002943,GO:0017150,GO:0050660,GO:0055114" tRNA dihydrouridine synthesis|tRNA dihydrouridine synthase activity|flavin adenine dinucleotide binding|oxidation-reduction process DUS4L-BCAP29 127.5390398 97.43577296 157.6423066 1.617909951 0.694131313 0.267913979 1 0.722726738 1.219675775 115253422 DUS4L-BCAP29 readthrough DUSP1 559.432742 592.7342855 526.1311984 0.887634158 -0.171962908 0.667707773 1 14.91301566 13.80751139 1843 dual specificity phosphatase 1 "GO:0000188,GO:0001706,GO:0004721,GO:0004722,GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0006470,GO:0007162,GO:0008138,GO:0008330,GO:0009416,GO:0017017,GO:0019838,GO:0032355,GO:0032526,GO:0032870,GO:0033574,GO:0035335,GO:0035556,GO:0035970,GO:0042542,GO:0043065,GO:0043066,GO:0043407,GO:0043409,GO:0051019,GO:0051384,GO:0051447,GO:0051591,GO:0051592,GO:0070262,GO:0070373,GO:0071850,GO:0090027,GO:0090266,GO:0106306,GO:0106307,GO:1903753,GO:1990869,GO:2000279" inactivation of MAPK activity|endoderm formation|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|protein dephosphorylation|negative regulation of cell adhesion|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine/threonine phosphatase activity|response to light stimulus|MAP kinase tyrosine/serine/threonine phosphatase activity|growth factor binding|response to estradiol|response to retinoic acid|cellular response to hormone stimulus|response to testosterone|peptidyl-tyrosine dephosphorylation|intracellular signal transduction|peptidyl-threonine dephosphorylation|response to hydrogen peroxide|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|mitogen-activated protein kinase binding|response to glucocorticoid|negative regulation of meiotic cell cycle|response to cAMP|response to calcium ion|peptidyl-serine dephosphorylation|negative regulation of ERK1 and ERK2 cascade|mitotic cell cycle arrest|negative regulation of monocyte chemotaxis|regulation of mitotic cell cycle spindle assembly checkpoint|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of p38MAPK cascade|cellular response to chemokine|negative regulation of DNA biosynthetic process "hsa04010,hsa04726,hsa05012,hsa05418" MAPK signaling pathway|Serotonergic synapse|Parkinson disease|Fluid shear stress and atherosclerosis DUSP10 310.2095874 360.3093688 260.109806 0.721906863 -0.470115376 0.315601791 1 2.19042113 1.649395177 11221 dual specificity phosphatase 10 "GO:0000188,GO:0002819,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006470,GO:0008330,GO:0008432,GO:0010633,GO:0016311,GO:0016607,GO:0016791,GO:0017017,GO:0030336,GO:0032496,GO:0033549,GO:0035335,GO:0035970,GO:0043508,GO:0044387,GO:0045591,GO:0046329,GO:0048273,GO:0048709,GO:0048715,GO:0050680,GO:0051019,GO:0060266,GO:0070373,GO:0090335,GO:0106306,GO:0106307,GO:1903753,GO:1905042,GO:1990264" inactivation of MAPK activity|regulation of adaptive immune response|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|JUN kinase binding|negative regulation of epithelial cell migration|dephosphorylation|nuclear speck|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|negative regulation of cell migration|response to lipopolysaccharide|MAP kinase phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|negative regulation of JUN kinase activity|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of regulatory T cell differentiation|negative regulation of JNK cascade|mitogen-activated protein kinase p38 binding|oligodendrocyte differentiation|negative regulation of oligodendrocyte differentiation|negative regulation of epithelial cell proliferation|mitogen-activated protein kinase binding|negative regulation of respiratory burst involved in inflammatory response|negative regulation of ERK1 and ERK2 cascade|regulation of brown fat cell differentiation|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of p38MAPK cascade|negative regulation of epithelium regeneration|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity hsa04010 MAPK signaling pathway DUSP11 374.8631729 368.4290165 381.2973292 1.034927522 0.049529737 0.916829092 1 11.38476507 12.289945 8446 dual specificity phosphatase 11 "GO:0001650,GO:0003723,GO:0004651,GO:0004725,GO:0005634,GO:0005654,GO:0006396,GO:0006470,GO:0008138,GO:0016070,GO:0016607,GO:0016791,GO:0035335,GO:0045171,GO:0098507,GO:0098519" "fibrillar center|RNA binding|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|nucleus|nucleoplasm|RNA processing|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|RNA metabolic process|nuclear speck|phosphatase activity|peptidyl-tyrosine dephosphorylation|intercellular bridge|polynucleotide 5' dephosphorylation|nucleotide phosphatase activity, acting on free nucleotides" DUSP12 580.1529863 594.7641975 565.5417751 0.950867213 -0.072684209 0.857563637 1 23.77482904 23.58051063 11266 dual specificity phosphatase 12 "GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006470,GO:0008138,GO:0008270,GO:0016311,GO:0016791,GO:0019900,GO:0033133,GO:0035335,GO:0106306,GO:0106307" protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding|dephosphorylation|phosphatase activity|kinase binding|positive regulation of glucokinase activity|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity DUSP14 441.3130972 499.3583364 383.267858 0.767520696 -0.381722442 0.366350515 1 8.211278607 6.573804929 11072 dual specificity phosphatase 14 "GO:0000188,GO:0003723,GO:0004725,GO:0005515,GO:0017017,GO:0035335,GO:0106306,GO:0106307" inactivation of MAPK activity|RNA binding|protein tyrosine phosphatase activity|protein binding|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity DUSP15 27.34714965 17.25425146 37.44004783 2.169902758 1.117630391 0.275051179 1 0.226860583 0.513470203 128853 dual specificity phosphatase 15 "GO:0004725,GO:0005515,GO:0005829,GO:0005886,GO:0007179,GO:0008138,GO:0016311,GO:0016791,GO:0035335,GO:0042127,GO:0046330,GO:0106306,GO:0106307" protein tyrosine phosphatase activity|protein binding|cytosol|plasma membrane|transforming growth factor beta receptor signaling pathway|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|peptidyl-tyrosine dephosphorylation|regulation of cell population proliferation|positive regulation of JNK cascade|protein serine phosphatase activity|protein threonine phosphatase activity DUSP16 784.2645402 807.9049508 760.6241296 0.941477248 -0.087001865 0.816316912 1 6.28147615 6.168612278 80824 dual specificity phosphatase 16 "GO:0000188,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0008330,GO:0016311,GO:0016791,GO:0017017,GO:0031410,GO:0035335,GO:0035970,GO:0045204,GO:0045209,GO:0051019,GO:0106306,GO:0106307" "inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|cytoplasmic vesicle|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity" hsa04010 MAPK signaling pathway DUSP18 286.7522771 238.5146526 334.9899016 1.404483532 0.490039708 0.307613834 1 2.284835582 3.347245254 150290 dual specificity phosphatase 18 "GO:0000188,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005743,GO:0008138,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970,GO:0106306,GO:0106307" inactivation of MAPK activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial inner membrane|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity DUSP19 9.538161268 12.17947162 6.896850916 0.566268483 -0.82044186 0.599184136 1 0.118830143 0.070188335 142679 dual specificity phosphatase 19 "GO:0004725,GO:0004860,GO:0005078,GO:0005515,GO:0005737,GO:0006469,GO:0008579,GO:0030295,GO:0031435,GO:0032147,GO:0035335,GO:0043405,GO:0043410,GO:0043507,GO:0043508,GO:0045860,GO:0046329,GO:0046330,GO:0106306,GO:0106307" protein tyrosine phosphatase activity|protein kinase inhibitor activity|MAP-kinase scaffold activity|protein binding|cytoplasm|negative regulation of protein kinase activity|JUN kinase phosphatase activity|protein kinase activator activity|mitogen-activated protein kinase kinase kinase binding|activation of protein kinase activity|peptidyl-tyrosine dephosphorylation|regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|negative regulation of JUN kinase activity|positive regulation of protein kinase activity|negative regulation of JNK cascade|positive regulation of JNK cascade|protein serine phosphatase activity|protein threonine phosphatase activity DUSP22 178.0965647 152.2433953 203.9497342 1.339629439 0.421833986 0.453463605 1 1.114730503 1.557652217 56940 dual specificity phosphatase 22 "GO:0000122,GO:0004725,GO:0004726,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007179,GO:0008138,GO:0030336,GO:0031941,GO:0035335,GO:0042127,GO:0046330,GO:0051895,GO:0061851,GO:0071364,GO:0106306,GO:0106307,GO:1903996,GO:1990782" negative regulation of transcription by RNA polymerase II|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|nucleus|cytoplasm|cytosol|plasma membrane|transforming growth factor beta receptor signaling pathway|protein tyrosine/serine/threonine phosphatase activity|negative regulation of cell migration|filamentous actin|peptidyl-tyrosine dephosphorylation|regulation of cell population proliferation|positive regulation of JNK cascade|negative regulation of focal adhesion assembly|leading edge of lamellipodium|cellular response to epidermal growth factor stimulus|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of non-membrane spanning protein tyrosine kinase activity|protein tyrosine kinase binding DUSP23 128.3704033 154.2733072 102.4674993 0.664194611 -0.590322077 0.345396727 1 11.29103868 7.822492811 54935 dual specificity phosphatase 23 "GO:0004725,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008138,GO:0016311,GO:0016791,GO:0035335,GO:0106306,GO:0106307" protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|cytosol|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity DUSP28 62.6479219 73.07682972 52.21901408 0.714576895 -0.484838828 0.546469632 1 0.747542643 0.557186867 285193 dual specificity phosphatase 28 "GO:0004725,GO:0008138,GO:0016311,GO:0016791,GO:0035335,GO:0106306,GO:0106307" protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity DUSP3 2575.21323 3113.884911 2036.541549 0.654019531 -0.612594375 0.055240896 1 38.51215766 26.2726874 1845 dual specificity phosphatase 3 "GO:0000188,GO:0001772,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0008092,GO:0008138,GO:0016311,GO:0016791,GO:0019901,GO:0030336,GO:0030971,GO:0033549,GO:0035335,GO:0042059,GO:0043409,GO:0045931,GO:0046329,GO:0050860,GO:0050868,GO:0050922,GO:0051893,GO:0070373,GO:0071364,GO:0106306,GO:0106307,GO:0120183,GO:1990264,GO:1990782" inactivation of MAPK activity|immunological synapse|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytosol|cytoskeletal protein binding|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|protein kinase binding|negative regulation of cell migration|receptor tyrosine kinase binding|MAP kinase phosphatase activity|peptidyl-tyrosine dephosphorylation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAPK cascade|positive regulation of mitotic cell cycle|negative regulation of JNK cascade|negative regulation of T cell receptor signaling pathway|negative regulation of T cell activation|negative regulation of chemotaxis|regulation of focal adhesion assembly|negative regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of focal adhesion disassembly|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity|protein tyrosine kinase binding hsa04010 MAPK signaling pathway DUSP4 208.1268405 218.2155332 198.0381477 0.907534605 -0.13997544 0.799651957 1 1.51957197 1.438468638 1846 dual specificity phosphatase 4 "GO:0000188,GO:0001706,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006470,GO:0008330,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970,GO:0051019,GO:0070373,GO:0106306,GO:0106307,GO:1990439" inactivation of MAPK activity|endoderm formation|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|mitogen-activated protein kinase binding|negative regulation of ERK1 and ERK2 cascade|protein serine phosphatase activity|protein threonine phosphatase activity|MAP kinase serine/threonine phosphatase activity hsa04010 MAPK signaling pathway DUSP5 1143.761597 1237.231325 1050.291868 0.848905008 -0.236324969 0.493439438 1 25.2972959 22.40005713 1847 dual specificity phosphatase 5 "GO:0000165,GO:0000187,GO:0000188,GO:0001706,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006470,GO:0008138,GO:0008330,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970,GO:0051019,GO:0106306,GO:0106307" MAPK cascade|activation of MAPK activity|inactivation of MAPK activity|endoderm formation|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity hsa04010 MAPK signaling pathway DUSP6 1517.30102 1178.363879 1856.238161 1.575267363 0.655596711 0.048191804 1 16.45436269 27.03654988 1848 dual specificity phosphatase 6 "GO:0000165,GO:0000187,GO:0000188,GO:0004721,GO:0004725,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0008330,GO:0014070,GO:0017017,GO:0030154,GO:0035335,GO:0035970,GO:0042493,GO:0043065,GO:0051019,GO:0051409,GO:0060420,GO:0070373,GO:0070848,GO:0106306,GO:0106307" MAPK cascade|activation of MAPK activity|inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|response to organic cyclic compound|MAP kinase tyrosine/serine/threonine phosphatase activity|cell differentiation|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|response to drug|positive regulation of apoptotic process|mitogen-activated protein kinase binding|response to nitrosative stress|regulation of heart growth|negative regulation of ERK1 and ERK2 cascade|response to growth factor|protein serine phosphatase activity|protein threonine phosphatase activity "hsa04010,hsa05202,hsa05221" MAPK signaling pathway|Transcriptional misregulation in cancer|Acute myeloid leukemia DUSP7 1072.298997 1066.718723 1077.879272 1.010462504 0.015015788 0.968536669 1 16.0742458 16.94208036 1849 dual specificity phosphatase 7 "GO:0000165,GO:0000187,GO:0000188,GO:0004721,GO:0004725,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0008330,GO:0017017,GO:0035335,GO:0035970,GO:0043407,GO:0051019,GO:0106306,GO:0106307" MAPK cascade|activation of MAPK activity|inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|negative regulation of MAP kinase activity|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity hsa04010 MAPK signaling pathway DUSP8 71.00782366 72.06187375 69.95377357 0.970745971 -0.042834281 0.975546187 1 0.613597795 0.62130567 1850 dual specificity phosphatase 8 "GO:0000188,GO:0004721,GO:0004725,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0008330,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970,GO:0051019,GO:0106306,GO:0106307" inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|nucleus|cytoplasm|cytosol|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity hsa04010 MAPK signaling pathway DUSP9 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.070853121 0.071743162 1852 dual specificity phosphatase 9 "GO:0000165,GO:0000187,GO:0000188,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0007254,GO:0008330,GO:0017017,GO:0035335,GO:0035970,GO:0043065,GO:0051019,GO:0060420,GO:0070373,GO:0106306,GO:0106307" MAPK cascade|activation of MAPK activity|inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|cytosol|protein dephosphorylation|JNK cascade|protein tyrosine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|positive regulation of apoptotic process|mitogen-activated protein kinase binding|regulation of heart growth|negative regulation of ERK1 and ERK2 cascade|protein serine phosphatase activity|protein threonine phosphatase activity "hsa04010,hsa04550" MAPK signaling pathway|Signaling pathways regulating pluripotency of stem cells DUT 1272.358892 1171.259188 1373.458597 1.172634214 0.229753056 0.498530174 1 18.5491388 22.68831495 1854 deoxyuridine triphosphatase "GO:0000287,GO:0001889,GO:0003723,GO:0004170,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006139,GO:0006226,GO:0006260,GO:0014070,GO:0015949,GO:0030547,GO:0032556,GO:0042802,GO:0042975,GO:0043254,GO:0046081,GO:0070062,GO:2000272" magnesium ion binding|liver development|RNA binding|dUTP diphosphatase activity|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|nucleobase-containing compound metabolic process|dUMP biosynthetic process|DNA replication|response to organic cyclic compound|nucleobase-containing small molecule interconversion|receptor inhibitor activity|pyrimidine deoxyribonucleotide binding|identical protein binding|peroxisome proliferator activated receptor binding|regulation of protein-containing complex assembly|dUTP catabolic process|extracellular exosome|negative regulation of signaling receptor activity "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes DVL1 2578.369191 2487.657078 2669.081304 1.072929757 0.101555628 0.750835397 1 41.09297296 45.98908643 1855 dishevelled segment polarity protein 1 "GO:0001505,GO:0001934,GO:0003674,GO:0005109,GO:0005515,GO:0005829,GO:0005874,GO:0006355,GO:0006469,GO:0007269,GO:0007411,GO:0007507,GO:0007528,GO:0008013,GO:0010976,GO:0014069,GO:0016328,GO:0019899,GO:0019901,GO:0021915,GO:0022007,GO:0030136,GO:0030426,GO:0031122,GO:0031410,GO:0032091,GO:0032436,GO:0034504,GO:0035176,GO:0035372,GO:0035556,GO:0035567,GO:0042802,GO:0043005,GO:0043025,GO:0043113,GO:0043197,GO:0045202,GO:0045944,GO:0048668,GO:0048675,GO:0048813,GO:0050808,GO:0050821,GO:0060070,GO:0060071,GO:0060134,GO:0060997,GO:0071340,GO:0090090,GO:0090103,GO:0090179,GO:0098685,GO:0098793,GO:0098978,GO:0099054,GO:0150012,GO:1903827,GO:1904886,GO:1905386,GO:1990909,GO:2000300,GO:2000463" "regulation of neurotransmitter levels|positive regulation of protein phosphorylation|molecular_function|frizzled binding|protein binding|cytosol|microtubule|regulation of transcription, DNA-templated|negative regulation of protein kinase activity|neurotransmitter secretion|axon guidance|heart development|neuromuscular junction development|beta-catenin binding|positive regulation of neuron projection development|postsynaptic density|lateral plasma membrane|enzyme binding|protein kinase binding|neural tube development|convergent extension involved in neural plate elongation|clathrin-coated vesicle|growth cone|cytoplasmic microtubule organization|cytoplasmic vesicle|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein localization to nucleus|social behavior|protein localization to microtubule|intracellular signal transduction|non-canonical Wnt signaling pathway|identical protein binding|neuron projection|neuronal cell body|receptor clustering|dendritic spine|synapse|positive regulation of transcription by RNA polymerase II|collateral sprouting|axon extension|dendrite morphogenesis|synapse organization|protein stabilization|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|prepulse inhibition|dendritic spine morphogenesis|skeletal muscle acetylcholine-gated channel clustering|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|Schaffer collateral - CA1 synapse|presynapse|glutamatergic synapse|presynapse assembly|positive regulation of neuron projection arborization|regulation of cellular protein localization|beta-catenin destruction complex disassembly|positive regulation of protein localization to presynapse|Wnt signalosome|regulation of synaptic vesicle exocytosis|positive regulation of excitatory postsynaptic potential" "hsa04150,hsa04310,hsa04330,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Notch signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer DVL2 1710.477426 1485.895538 1935.059314 1.302284895 0.381045095 0.243541485 1 25.17743963 34.20058197 1856 dishevelled segment polarity protein 2 "GO:0001843,GO:0001934,GO:0003151,GO:0005109,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0007379,GO:0007507,GO:0016235,GO:0016328,GO:0016604,GO:0019901,GO:0019904,GO:0022007,GO:0030674,GO:0031267,GO:0031410,GO:0034613,GO:0035329,GO:0035567,GO:0042802,GO:0043507,GO:0043547,GO:0043621,GO:0044340,GO:0045177,GO:0045334,GO:0045944,GO:0051091,GO:0060070,GO:0060071,GO:0061024,GO:0061098,GO:0090090,GO:0090103,GO:0090179,GO:0150012,GO:1904886" "neural tube closure|positive regulation of protein phosphorylation|outflow tract morphogenesis|frizzled binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|segment specification|heart development|aggresome|lateral plasma membrane|nuclear body|protein kinase binding|protein domain specific binding|convergent extension involved in neural plate elongation|protein-macromolecule adaptor activity|small GTPase binding|cytoplasmic vesicle|cellular protein localization|hippo signaling|non-canonical Wnt signaling pathway|identical protein binding|positive regulation of JUN kinase activity|positive regulation of GTPase activity|protein self-association|canonical Wnt signaling pathway involved in regulation of cell proliferation|apical part of cell|clathrin-coated endocytic vesicle|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|membrane organization|positive regulation of protein tyrosine kinase activity|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|positive regulation of neuron projection arborization|beta-catenin destruction complex disassembly" "hsa04150,hsa04310,hsa04330,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Notch signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer DVL3 2504.909093 2281.621017 2728.197169 1.195727577 0.257888737 0.419058582 1 20.89621256 26.0624808 1857 dishevelled segment polarity protein 3 "GO:0000785,GO:0001934,GO:0002020,GO:0005102,GO:0005109,GO:0005515,GO:0005829,GO:0008013,GO:0031267,GO:0035556,GO:0035567,GO:0038031,GO:0042493,GO:0043507,GO:0043547,GO:0045893,GO:0045944,GO:0050821,GO:0060070,GO:0060071,GO:0090090,GO:0090179,GO:0150012,GO:1903827,GO:1904886" "chromatin|positive regulation of protein phosphorylation|protease binding|signaling receptor binding|frizzled binding|protein binding|cytosol|beta-catenin binding|small GTPase binding|intracellular signal transduction|non-canonical Wnt signaling pathway|non-canonical Wnt signaling pathway via JNK cascade|response to drug|positive regulation of JUN kinase activity|positive regulation of GTPase activity|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein stabilization|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|negative regulation of canonical Wnt signaling pathway|planar cell polarity pathway involved in neural tube closure|positive regulation of neuron projection arborization|regulation of cellular protein localization|beta-catenin destruction complex disassembly" "hsa04150,hsa04310,hsa04330,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Notch signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer DXO 291.3317031 282.1577592 300.505647 1.065027054 0.090890078 0.85542341 1 9.340062164 10.37591335 1797 decapping exoribonuclease "GO:0000166,GO:0000287,GO:0000956,GO:0003729,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006402,GO:0008409,GO:0034353,GO:0050779,GO:0071028,GO:0090305,GO:0110152,GO:0110155" nucleotide binding|magnesium ion binding|nuclear-transcribed mRNA catabolic process|mRNA binding|nucleus|nucleoplasm|cytosol|plasma membrane|mRNA catabolic process|5'-3' exonuclease activity|RNA pyrophosphohydrolase activity|RNA destabilization|nuclear mRNA surveillance|nucleic acid phosphodiester bond hydrolysis|RNA NAD-cap (NAD-forming) hydrolase activity|NAD-cap decapping DYM 1571.518771 1382.370029 1760.667512 1.273658627 0.34897865 0.289942667 1 4.777356892 6.346826956 54808 dymeclin "GO:0005515,GO:0005737,GO:0005794,GO:0007030,GO:0016020,GO:0019899,GO:0060348" protein binding|cytoplasm|Golgi apparatus|Golgi organization|membrane|enzyme binding|bone development DYNAP 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.099684433 0 284254 dynactin associated protein "GO:0000139,GO:0005515,GO:0005794,GO:0005886,GO:0008284,GO:0016021,GO:0032148,GO:0042981,GO:1901625" Golgi membrane|protein binding|Golgi apparatus|plasma membrane|positive regulation of cell population proliferation|integral component of membrane|activation of protein kinase B activity|regulation of apoptotic process|cellular response to ergosterol DYNC1H1 20526.13144 19676.95136 21375.31152 1.086312159 0.119438731 0.743589696 1 49.97834354 56.630765 1778 dynein cytoplasmic 1 heavy chain 1 "GO:0000086,GO:0000278,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0005881,GO:0005938,GO:0006888,GO:0007018,GO:0007052,GO:0007097,GO:0008090,GO:0008569,GO:0010389,GO:0016020,GO:0019886,GO:0030286,GO:0031122,GO:0032388,GO:0033962,GO:0034063,GO:0035578,GO:0043312,GO:0045505,GO:0051293,GO:0051301,GO:0051959,GO:0060236,GO:0070062,GO:0072382,GO:0090235,GO:0097711,GO:0120162,GO:1904115,GO:1905832" "G2/M transition of mitotic cell cycle|mitotic cell cycle|RNA binding|protein binding|ATP binding|extracellular region|centrosome|cytosol|cytoplasmic dynein complex|microtubule|cytoplasmic microtubule|cell cortex|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|mitotic spindle organization|nuclear migration|retrograde axonal transport|ATP-dependent microtubule motor activity, minus-end-directed|regulation of G2/M transition of mitotic cell cycle|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|dynein complex|cytoplasmic microtubule organization|positive regulation of intracellular transport|P-body assembly|stress granule assembly|azurophil granule lumen|neutrophil degranulation|dynein intermediate chain binding|establishment of spindle localization|cell division|dynein light intermediate chain binding|regulation of mitotic spindle organization|extracellular exosome|minus-end-directed vesicle transport along microtubule|regulation of metaphase plate congression|ciliary basal body-plasma membrane docking|positive regulation of cold-induced thermogenesis|axon cytoplasm|positive regulation of spindle assembly" "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1I1 14.1203089 22.3290313 5.911586499 0.264748901 -1.917303399 0.133452681 1 0.338386195 0.093446434 1780 dynein cytoplasmic 1 intermediate chain 1 "GO:0000776,GO:0000777,GO:0000922,GO:0003774,GO:0003777,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005868,GO:0005874,GO:0006888,GO:0007018,GO:0008017,GO:0010970,GO:0019886,GO:0030507,GO:0031982,GO:0036464,GO:0045503,GO:0045504,GO:0047496,GO:0048471,GO:0055037" kinetochore|condensed chromosome kinetochore|spindle pole|motor activity|microtubule motor activity|protein binding|nucleus|cytoplasm|cytosol|cytoplasmic dynein complex|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|microtubule binding|transport along microtubule|antigen processing and presentation of exogenous peptide antigen via MHC class II|spectrin binding|vesicle|cytoplasmic ribonucleoprotein granule|dynein light chain binding|dynein heavy chain binding|vesicle transport along microtubule|perinuclear region of cytoplasm|recycling endosome "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1I2 2105.824548 2008.597861 2203.051235 1.096810505 0.133314295 0.678810323 1 22.47148128 25.70864768 1781 dynein cytoplasmic 1 intermediate chain 2 "GO:0000086,GO:0003777,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0006888,GO:0007018,GO:0010389,GO:0010970,GO:0016032,GO:0019886,GO:0031982,GO:0045503,GO:0045504,GO:0097711" G2/M transition of mitotic cell cycle|microtubule motor activity|protein binding|cytoplasm|centrosome|cytosol|cytoplasmic dynein complex|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|regulation of G2/M transition of mitotic cell cycle|transport along microtubule|viral process|antigen processing and presentation of exogenous peptide antigen via MHC class II|vesicle|dynein light chain binding|dynein heavy chain binding|ciliary basal body-plasma membrane docking "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1LI1 1076.89995 1212.872382 940.9275178 0.775784437 -0.366272261 0.292705244 1 24.71939936 20.00298947 51143 dynein cytoplasmic 1 light intermediate chain 1 "GO:0000226,GO:0000776,GO:0000777,GO:0000922,GO:0003723,GO:0003774,GO:0005515,GO:0005524,GO:0005525,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0005886,GO:0006888,GO:0007018,GO:0007049,GO:0016020,GO:0016032,GO:0019003,GO:0019886,GO:0030667,GO:0043312,GO:0045504,GO:0051301,GO:0090267,GO:0101003" microtubule cytoskeleton organization|kinetochore|condensed chromosome kinetochore|spindle pole|RNA binding|motor activity|protein binding|ATP binding|GTP binding|centrosome|cytosol|cytoplasmic dynein complex|microtubule|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|cell cycle|membrane|viral process|GDP binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|secretory granule membrane|neutrophil degranulation|dynein heavy chain binding|cell division|positive regulation of mitotic cell cycle spindle assembly checkpoint|ficolin-1-rich granule membrane "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1LI2 2485.850338 2224.783483 2746.917193 1.234689674 0.304148482 0.340643215 1 25.52728474 32.87595433 1783 dynein cytoplasmic 1 light intermediate chain 2 "GO:0000226,GO:0000776,GO:0003774,GO:0005524,GO:0005764,GO:0005770,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0006888,GO:0007018,GO:0016020,GO:0019886,GO:0042802,GO:0045504,GO:0051642,GO:1990090" microtubule cytoskeleton organization|kinetochore|motor activity|ATP binding|lysosome|late endosome|centrosome|cytosol|cytoplasmic dynein complex|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|identical protein binding|dynein heavy chain binding|centrosome localization|cellular response to nerve growth factor stimulus "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC2H1 1168.614656 1083.972974 1253.256338 1.156169358 0.209352742 0.542912462 1 4.071448169 4.910054304 79659 dynein cytoplasmic 2 heavy chain 1 "GO:0001822,GO:0003774,GO:0005515,GO:0005524,GO:0005794,GO:0005868,GO:0005874,GO:0005886,GO:0005929,GO:0005930,GO:0007018,GO:0007030,GO:0007368,GO:0008569,GO:0009953,GO:0016485,GO:0021522,GO:0030286,GO:0030326,GO:0030900,GO:0031514,GO:0035721,GO:0035735,GO:0045177,GO:0045505,GO:0045880,GO:0051959,GO:0060271,GO:0060976,GO:0061512,GO:0070062,GO:0097542,GO:1905515" "kidney development|motor activity|protein binding|ATP binding|Golgi apparatus|cytoplasmic dynein complex|microtubule|plasma membrane|cilium|axoneme|microtubule-based movement|Golgi organization|determination of left/right symmetry|ATP-dependent microtubule motor activity, minus-end-directed|dorsal/ventral pattern formation|protein processing|spinal cord motor neuron differentiation|dynein complex|embryonic limb morphogenesis|forebrain development|motile cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|apical part of cell|dynein intermediate chain binding|positive regulation of smoothened signaling pathway|dynein light intermediate chain binding|cilium assembly|coronary vasculature development|protein localization to cilium|extracellular exosome|ciliary tip|non-motile cilium assembly" "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC2I1 574.2089866 626.2278325 522.1901408 0.833866069 -0.262112411 0.508191383 1 6.442459987 5.603559164 55112 dynein 2 intermediate chain 1 "GO:0000242,GO:0000922,GO:0005515,GO:0005615,GO:0005813,GO:0005868,GO:0005929,GO:0007018,GO:0031021,GO:0035721,GO:0035735,GO:0042073,GO:0045503,GO:0045504,GO:0048704,GO:0060271,GO:0097014,GO:0097542,GO:0097546" pericentriolar material|spindle pole|protein binding|extracellular space|centrosome|cytoplasmic dynein complex|cilium|microtubule-based movement|interphase microtubule organizing center|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|intraciliary transport|dynein light chain binding|dynein heavy chain binding|embryonic skeletal system morphogenesis|cilium assembly|ciliary plasm|ciliary tip|ciliary base DYNC2I2 2379.595682 2167.945948 2591.245416 1.1952537 0.257316871 0.420704085 1 65.51241899 81.67697825 89891 dynein 2 intermediate chain 2 "GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005868,GO:0005929,GO:0005930,GO:0007018,GO:0030175,GO:0035721,GO:0035735,GO:0036064,GO:0042073,GO:0045503,GO:0045504,GO:0060271,GO:0097014,GO:0097542" protein binding|cytoplasm|centrosome|centriole|cytosol|cytoplasmic dynein complex|cilium|axoneme|microtubule-based movement|filopodium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|dynein light chain binding|dynein heavy chain binding|cilium assembly|ciliary plasm|ciliary tip DYNC2LI1 157.8837984 151.2284393 164.5391576 1.088017296 0.121701491 0.844026767 1 2.516158656 2.855549881 51626 dynein cytoplasmic 2 light intermediate chain 1 "GO:0003774,GO:0005515,GO:0005737,GO:0005794,GO:0005813,GO:0005868,GO:0005881,GO:0005929,GO:0005930,GO:0007368,GO:0030990,GO:0031514,GO:0035721,GO:0035735,GO:0035869,GO:0036064,GO:0045177,GO:0045504,GO:0097542,GO:1902017" motor activity|protein binding|cytoplasm|Golgi apparatus|centrosome|cytoplasmic dynein complex|cytoplasmic microtubule|cilium|axoneme|determination of left/right symmetry|intraciliary transport particle|motile cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|apical part of cell|dynein heavy chain binding|ciliary tip|regulation of cilium assembly "hsa04962,hsa05132" Vasopressin-regulated water reabsorption|Salmonella infection DYNLL1 4066.746196 4315.592778 3817.899614 0.884675596 -0.176779568 0.57946122 1 232.5207975 214.5664328 8655 dynein light chain LC8-type 1 "GO:0000086,GO:0000776,GO:0003774,GO:0004857,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0005886,GO:0005929,GO:0006888,GO:0006915,GO:0007286,GO:0008022,GO:0008180,GO:0010389,GO:0016020,GO:0016032,GO:0016236,GO:0019886,GO:0019899,GO:0019904,GO:0021762,GO:0030235,GO:0030286,GO:0035721,GO:0035735,GO:0035774,GO:0042326,GO:0042802,GO:0043086,GO:0043312,GO:0044458,GO:0044877,GO:0045019,GO:0045505,GO:0051959,GO:0060271,GO:0070821,GO:0072686,GO:0097110,GO:0097542,GO:0097711,GO:0101003,GO:1902857,GO:1904115,GO:2000582" "G2/M transition of mitotic cell cycle|kinetochore|motor activity|enzyme inhibitor activity|protein binding|nucleus|cytoplasm|mitochondrion|centrosome|cytosol|cytoplasmic dynein complex|microtubule|plasma membrane|cilium|endoplasmic reticulum to Golgi vesicle-mediated transport|apoptotic process|spermatid development|protein C-terminus binding|COP9 signalosome|regulation of G2/M transition of mitotic cell cycle|membrane|viral process|macroautophagy|antigen processing and presentation of exogenous peptide antigen via MHC class II|enzyme binding|protein domain specific binding|substantia nigra development|nitric-oxide synthase regulator activity|dynein complex|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|positive regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of phosphorylation|identical protein binding|negative regulation of catalytic activity|neutrophil degranulation|motile cilium assembly|protein-containing complex binding|negative regulation of nitric oxide biosynthetic process|dynein intermediate chain binding|dynein light intermediate chain binding|cilium assembly|tertiary granule membrane|mitotic spindle|scaffold protein binding|ciliary tip|ciliary basal body-plasma membrane docking|ficolin-1-rich granule membrane|positive regulation of non-motile cilium assembly|axon cytoplasm|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed" "hsa04962,hsa05132" Vasopressin-regulated water reabsorption|Salmonella infection DYNLL2 1496.804454 1730.499926 1263.108982 0.729909873 -0.454209759 0.171000799 1 12.87552761 9.802801362 140735 dynein light chain LC8-type 2 "GO:0003774,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0005886,GO:0005929,GO:0006888,GO:0014069,GO:0016020,GO:0016236,GO:0019886,GO:0030286,GO:0031475,GO:0035735,GO:0042802,GO:0044877,GO:0045505,GO:0051959,GO:0060271,GO:0097110,GO:0097542,GO:0097731,GO:0098794,GO:0098978,GO:2000582" "motor activity|protein binding|nucleus|centrosome|cytosol|cytoplasmic dynein complex|microtubule|plasma membrane|cilium|endoplasmic reticulum to Golgi vesicle-mediated transport|postsynaptic density|membrane|macroautophagy|antigen processing and presentation of exogenous peptide antigen via MHC class II|dynein complex|myosin V complex|intraciliary transport involved in cilium assembly|identical protein binding|protein-containing complex binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium assembly|scaffold protein binding|ciliary tip|9+0 non-motile cilium|postsynapse|glutamatergic synapse|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed" "hsa04962,hsa05132" Vasopressin-regulated water reabsorption|Salmonella infection DYNLRB1 3647.693098 4159.289558 3136.096638 0.753998151 -0.407367109 0.200855483 1 133.2405712 104.7906892 83658 dynein light chain roadblock-type 1 "GO:0003777,GO:0005515,GO:0005737,GO:0005813,GO:0005868,GO:0005874,GO:0005929,GO:0007018,GO:0007632,GO:0016020,GO:0035735,GO:0045505,GO:0097542" microtubule motor activity|protein binding|cytoplasm|centrosome|cytoplasmic dynein complex|microtubule|cilium|microtubule-based movement|visual behavior|membrane|intraciliary transport involved in cilium assembly|dynein intermediate chain binding|ciliary tip hsa05132 Salmonella infection DYNLRB2 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.095902872 0.194215163 83657 dynein light chain roadblock-type 2 "GO:0003777,GO:0005737,GO:0005813,GO:0005868,GO:0005874,GO:0005929,GO:0007018,GO:0035735,GO:0045505,GO:0097542" microtubule motor activity|cytoplasm|centrosome|cytoplasmic dynein complex|microtubule|cilium|microtubule-based movement|intraciliary transport involved in cilium assembly|dynein intermediate chain binding|ciliary tip hsa05132 Salmonella infection DYNLT1 941.9756325 879.9668246 1003.98444 1.140934422 0.190215872 0.59443044 1 61.0509799 72.65562646 6993 dynein light chain Tctex-type 1 "GO:0000132,GO:0003774,GO:0005515,GO:0005576,GO:0005739,GO:0005794,GO:0005819,GO:0005868,GO:0005881,GO:0008022,GO:0008277,GO:0010976,GO:0016358,GO:0019060,GO:0030027,GO:0034774,GO:0035022,GO:0035795,GO:0042802,GO:0043025,GO:0043087,GO:0043312,GO:0043657,GO:0044295,GO:0046718,GO:0048812,GO:0050768,GO:0051301,GO:0051493,GO:0060548,GO:0061564,GO:0075521,GO:0099503,GO:1904813" establishment of mitotic spindle orientation|motor activity|protein binding|extracellular region|mitochondrion|Golgi apparatus|spindle|cytoplasmic dynein complex|cytoplasmic microtubule|protein C-terminus binding|regulation of G protein-coupled receptor signaling pathway|positive regulation of neuron projection development|dendrite development|intracellular transport of viral protein in host cell|lamellipodium|secretory granule lumen|positive regulation of Rac protein signal transduction|negative regulation of mitochondrial membrane permeability|identical protein binding|neuronal cell body|regulation of GTPase activity|neutrophil degranulation|host cell|axonal growth cone|viral entry into host cell|neuron projection morphogenesis|negative regulation of neurogenesis|cell division|regulation of cytoskeleton organization|negative regulation of cell death|axon development|microtubule-dependent intracellular transport of viral material towards nucleus|secretory vesicle|ficolin-1-rich granule lumen hsa05132 Salmonella infection DYNLT2 11.94193921 8.119647747 15.76423066 1.941491941 0.957165719 0.487279695 1 0.473223837 0.958336731 6991 dynein light chain Tctex-type 2 "GO:0003774,GO:0005515,GO:0005737,GO:0005874,GO:0016020,GO:0030286" motor activity|protein binding|cytoplasm|microtubule|membrane|dynein complex DYNLT2B 105.5042024 106.5703767 104.4380282 0.97999117 -0.029159344 0.980988581 1 8.635861794 8.827622965 255758 dynein light chain Tctex-type 2B "GO:0000922,GO:0005515,GO:0005813,GO:0005868,GO:0005930,GO:0031021,GO:0035721,GO:0045505,GO:0060271,GO:0097546,GO:1902017,GO:1905799" spindle pole|protein binding|centrosome|cytoplasmic dynein complex|axoneme|interphase microtubule organizing center|intraciliary retrograde transport|dynein intermediate chain binding|cilium assembly|ciliary base|regulation of cilium assembly|regulation of intraciliary retrograde transport DYNLT3 432.6468774 412.0721232 453.2216316 1.099859967 0.137319853 0.750035124 1 9.702463661 11.1310299 6990 dynein light chain Tctex-type 3 "GO:0000776,GO:0000777,GO:0003774,GO:0005515,GO:0005634,GO:0005737,GO:0005868,GO:0005874,GO:0007049,GO:0007346,GO:0042802,GO:0051301" kinetochore|condensed chromosome kinetochore|motor activity|protein binding|nucleus|cytoplasm|cytoplasmic dynein complex|microtubule|cell cycle|regulation of mitotic cell cycle|identical protein binding|cell division hsa05132 Salmonella infection DYRK1A 1296.320959 1327.562407 1265.079511 0.952934118 -0.06955162 0.838929257 1 5.8057467 5.770811519 1859 dual specificity tyrosine phosphorylation regulated kinase 1A "GO:0000381,GO:0003713,GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005856,GO:0006468,GO:0007399,GO:0007623,GO:0016032,GO:0016607,GO:0018105,GO:0018107,GO:0018108,GO:0030424,GO:0030425,GO:0031115,GO:0033120,GO:0034205,GO:0036289,GO:0038083,GO:0042802,GO:0043518,GO:0043621,GO:0045893,GO:0046777,GO:0048025,GO:0048156,GO:0050321,GO:0090312,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|transcription coactivator activity|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytoskeleton|protein phosphorylation|nervous system development|circadian rhythm|viral process|nuclear speck|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|axon|dendrite|negative regulation of microtubule polymerization|positive regulation of RNA splicing|amyloid-beta formation|peptidyl-serine autophosphorylation|peptidyl-tyrosine autophosphorylation|identical protein binding|negative regulation of DNA damage response, signal transduction by p53 class mediator|protein self-association|positive regulation of transcription, DNA-templated|protein autophosphorylation|negative regulation of mRNA splicing, via spliceosome|tau protein binding|tau-protein kinase activity|positive regulation of protein deacetylation|ribonucleoprotein complex" DYRK1B 283.6007672 258.8137719 308.3877624 1.191543093 0.252831129 0.602701804 1 4.149415799 5.157184153 9149 dual specificity tyrosine phosphorylation regulated kinase 1B "GO:0003713,GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0006468,GO:0007520,GO:0018105,GO:0018107,GO:0018108,GO:0045893,GO:0046777,GO:0060612" "transcription coactivator activity|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|protein phosphorylation|myoblast fusion|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|positive regulation of transcription, DNA-templated|protein autophosphorylation|adipose tissue development" DYRK2 781.8580407 845.4583217 718.2577597 0.849548394 -0.235231962 0.524879822 1 4.446467434 3.940208187 8445 dual specificity tyrosine phosphorylation regulated kinase 2 "GO:0000151,GO:0000287,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0006974,GO:0007224,GO:0018105,GO:0018107,GO:0018108,GO:0030145,GO:0042771,GO:0045725,GO:0070885,GO:1901796,GO:1990904" ubiquitin ligase complex|magnesium ion binding|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|cellular response to DNA damage stimulus|smoothened signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|manganese ion binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of glycogen biosynthetic process|negative regulation of calcineurin-NFAT signaling cascade|regulation of signal transduction by p53 class mediator|ribonucleoprotein complex DYRK3 582.324675 507.4779842 657.1713658 1.294975125 0.372924385 0.343959747 1 3.09252432 4.177250113 8444 dual specificity tyrosine phosphorylation regulated kinase 3 "GO:0000242,GO:0000287,GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0007049,GO:0010494,GO:0016607,GO:0018105,GO:0018107,GO:0018108,GO:0030218,GO:0035063,GO:0035617,GO:0043066,GO:0043231,GO:0043518,GO:0051301,GO:0080135,GO:1902751,GO:1903008,GO:1903432" "pericentriolar material|magnesium ion binding|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|cell cycle|cytoplasmic stress granule|nuclear speck|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|erythrocyte differentiation|nuclear speck organization|stress granule disassembly|negative regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of DNA damage response, signal transduction by p53 class mediator|cell division|regulation of cellular response to stress|positive regulation of cell cycle G2/M phase transition|organelle disassembly|regulation of TORC1 signaling" DYRK4 288.274711 241.5595205 334.9899016 1.386779958 0.471738892 0.325298088 1 3.452070412 4.993477895 8798 dual specificity tyrosine phosphorylation regulated kinase 4 "GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005856,GO:0018105,GO:0018107,GO:0018108,GO:0043231,GO:0046872" protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytoskeleton|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|intracellular membrane-bounded organelle|metal ion binding DYSF 500.0820662 543.0014431 457.1626893 0.841918001 -0.248248367 0.545118732 1 3.543043996 3.111446014 8291 dysferlin "GO:0001778,GO:0002280,GO:0002281,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005768,GO:0005769,GO:0005770,GO:0005886,GO:0006906,GO:0006936,GO:0007009,GO:0016021,GO:0030139,GO:0030315,GO:0030659,GO:0031410,GO:0033292,GO:0034451,GO:0042383,GO:0050765,GO:0061025,GO:0070062" plasma membrane repair|monocyte activation involved in immune response|macrophage activation involved in immune response|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|endosome|early endosome|late endosome|plasma membrane|vesicle fusion|muscle contraction|plasma membrane organization|integral component of membrane|endocytic vesicle|T-tubule|cytoplasmic vesicle membrane|cytoplasmic vesicle|T-tubule organization|centriolar satellite|sarcolemma|negative regulation of phagocytosis|membrane fusion|extracellular exosome DZANK1 177.7793602 197.9164138 157.6423066 0.796509514 -0.3282365 0.561655025 1 1.529879144 1.271054059 55184 double zinc ribbon and ankyrin repeat domains 1 GO:0046872 metal ion binding DZIP1 968.2241947 822.1143344 1114.334055 1.355449003 0.438770835 0.215836643 1 5.287262323 7.475323131 22873 DAZ interacting zinc finger protein 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005814,GO:0005829,GO:0007224,GO:0007275,GO:0007281,GO:0007283,GO:0034451,GO:0036064,GO:0043393,GO:0045184,GO:0045724,GO:0046872,GO:0051220,GO:0060271,GO:0061512,GO:0097539" protein binding|nucleus|nucleoplasm|cytoplasm|centriole|cytosol|smoothened signaling pathway|multicellular organism development|germ cell development|spermatogenesis|centriolar satellite|ciliary basal body|regulation of protein binding|establishment of protein localization|positive regulation of cilium assembly|metal ion binding|cytoplasmic sequestering of protein|cilium assembly|protein localization to cilium|ciliary transition fiber DZIP1L 226.4163369 188.7818101 264.0508636 1.398709248 0.484096098 0.350787267 1 0.856809096 1.250050172 199221 DAZ interacting zinc finger protein 1 like "GO:0005515,GO:0005737,GO:0005814,GO:0005930,GO:0007224,GO:0021532,GO:0032880,GO:0033504,GO:0036064,GO:0046872,GO:0060271,GO:0061512,GO:1905349" protein binding|cytoplasm|centriole|axoneme|smoothened signaling pathway|neural tube patterning|regulation of protein localization|floor plate development|ciliary basal body|metal ion binding|cilium assembly|protein localization to cilium|ciliary transition zone assembly DZIP3 382.9719342 518.6424998 247.3013686 0.476824342 -1.068470208 0.015659703 0.552928428 4.684753515 2.330027749 9666 DAZ interacting zinc finger protein 3 "GO:0000209,GO:0003723,GO:0004842,GO:0005515,GO:0005737,GO:0019902,GO:0031593,GO:0046872,GO:0061630" protein polyubiquitination|RNA binding|ubiquitin-protein transferase activity|protein binding|cytoplasm|phosphatase binding|polyubiquitin modification-dependent protein binding|metal ion binding|ubiquitin protein ligase activity E2F1 2104.749218 1463.566506 2745.931929 1.876192108 0.907807557 0.004981606 0.269006715 27.55556892 53.92654749 1869 E2F transcription factor 1 "GO:0000077,GO:0000082,GO:0000083,GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001216,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005813,GO:0006351,GO:0006355,GO:0006357,GO:0006977,GO:0007283,GO:0008134,GO:0008630,GO:0010628,GO:0016032,GO:0019901,GO:0030900,GO:0032991,GO:0035189,GO:0043065,GO:0043276,GO:0043392,GO:0043565,GO:0045599,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0048146,GO:0048255,GO:0060252,GO:0070317,GO:0070345,GO:0071398,GO:0071456,GO:0071466,GO:0071930,GO:0072332,GO:0090575,GO:1900740,GO:1990086,GO:1990090,GO:1990837,GO:2000045" "DNA damage checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|centrosome|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|spermatogenesis|transcription factor binding|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of gene expression|viral process|protein kinase binding|forebrain development|protein-containing complex|Rb-E2F complex|positive regulation of apoptotic process|anoikis|negative regulation of DNA binding|sequence-specific DNA binding|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|positive regulation of fibroblast proliferation|mRNA stabilization|positive regulation of glial cell proliferation|negative regulation of G0 to G1 transition|negative regulation of fat cell proliferation|cellular response to fatty acid|cellular response to hypoxia|cellular response to xenobiotic stimulus|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|intrinsic apoptotic signaling pathway by p53 class mediator|RNA polymerase II transcription regulator complex|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|lens fiber cell apoptotic process|cellular response to nerve growth factor stimulus|sequence-specific double-stranded DNA binding|regulation of G1/S transition of mitotic cell cycle" "hsa01522,hsa04110,hsa04137,hsa04218,hsa04934,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05206,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Endocrine resistance|Cell cycle|Mitophagy - animal|Cellular senescence|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer E2F E2F2 175.3810255 134.9891438 215.7729072 1.598446372 0.676670343 0.229789627 1 1.145179886 1.909359523 1870 E2F transcription factor 2 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0007049,GO:0008134,GO:0043565,GO:0045944,GO:0046983,GO:0051726,GO:0072332,GO:0090575,GO:1903671,GO:1990086,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|cell cycle|transcription factor binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of cell cycle|intrinsic apoptotic signaling pathway by p53 class mediator|RNA polymerase II transcription regulator complex|negative regulation of sprouting angiogenesis|lens fiber cell apoptotic process|sequence-specific double-stranded DNA binding" "hsa01522,hsa04110,hsa04218,hsa04934,hsa05160,hsa05161,hsa05163,hsa05166,hsa05167,hsa05169,hsa05200,hsa05206,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Endocrine resistance|Cell cycle|Cellular senescence|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer E2F E2F3 782.9323797 851.5480575 714.316702 0.838844849 -0.253524097 0.492838561 1 4.769203254 4.172952138 1871 E2F transcription factor 3 "GO:0000082,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001216,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0006606,GO:0008284,GO:0043565,GO:0045944,GO:0046983,GO:0070345,GO:0090575,GO:1905461,GO:1990837" "G1/S transition of mitotic cell cycle|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein import into nucleus|positive regulation of cell population proliferation|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|protein dimerization activity|negative regulation of fat cell proliferation|RNA polymerase II transcription regulator complex|positive regulation of vascular associated smooth muscle cell apoptotic process|sequence-specific double-stranded DNA binding" "hsa01522,hsa04110,hsa04218,hsa04934,hsa05160,hsa05161,hsa05163,hsa05166,hsa05167,hsa05169,hsa05200,hsa05206,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Endocrine resistance|Cell cycle|Cellular senescence|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer E2F E2F4 1447.464529 1388.459765 1506.469293 1.084993121 0.117685895 0.725062118 1 33.32729331 37.71750512 1874 E2F transcription factor 4 "GO:0000083,GO:0000785,GO:0000978,GO:0000981,GO:0001216,GO:0001228,GO:0002064,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0006884,GO:0006977,GO:0008015,GO:0008134,GO:0009887,GO:0019904,GO:0042127,GO:0044458,GO:0045944,GO:0046983,GO:0090575,GO:0098534,GO:1903251,GO:1990837,GO:1990841" "regulation of transcription involved in G1/S transition of mitotic cell cycle|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|epithelial cell development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|cell volume homeostasis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|blood circulation|transcription factor binding|animal organ morphogenesis|protein domain specific binding|regulation of cell population proliferation|motile cilium assembly|positive regulation of transcription by RNA polymerase II|protein dimerization activity|RNA polymerase II transcription regulator complex|centriole assembly|multi-ciliated epithelial cell differentiation|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" "hsa04110,hsa04218,hsa04350" Cell cycle|Cellular senescence|TGF-beta signaling pathway E2F E2F5 381.1162122 391.7730038 370.4594206 0.945597111 -0.080702467 0.859763946 1 9.466565148 9.337153413 1875 E2F transcription factor 5 "GO:0000785,GO:0000978,GO:0000981,GO:0001216,GO:0001650,GO:0003700,GO:0005515,GO:0005654,GO:0005730,GO:0006357,GO:0008134,GO:0030030,GO:0043231,GO:0045944,GO:0046983,GO:0051726,GO:0090575" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity|fibrillar center|DNA-binding transcription factor activity|protein binding|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|transcription factor binding|cell projection organization|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of cell cycle|RNA polymerase II transcription regulator complex" "hsa04110,hsa04218,hsa04350" Cell cycle|Cellular senescence|TGF-beta signaling pathway E2F6 288.1356559 299.4120107 276.859301 0.92467667 -0.112979105 0.819526772 1 2.941641528 2.837236761 1876 E2F transcription factor 6 "GO:0000083,GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0046983,GO:0070317,GO:0071339,GO:0090575" "regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|protein dimerization activity|negative regulation of G0 to G1 transition|MLL1 complex|RNA polymerase II transcription regulator complex" E2F E2F7 2281.539108 1896.952705 2666.125511 1.405478115 0.491060989 0.125191535 1 17.07071117 25.02601101 144455 E2F transcription factor 7 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001217,GO:0001227,GO:0001890,GO:0002040,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0006977,GO:0008285,GO:0016607,GO:0030330,GO:0032466,GO:0032877,GO:0042802,GO:0045944,GO:0060707,GO:0060718,GO:0070365,GO:0071930,GO:0090575,GO:1990837,GO:2000134" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity|DNA-binding transcription repressor activity, RNA polymerase II-specific|placenta development|sprouting angiogenesis|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell population proliferation|nuclear speck|DNA damage response, signal transduction by p53 class mediator|negative regulation of cytokinesis|positive regulation of DNA endoreduplication|identical protein binding|positive regulation of transcription by RNA polymerase II|trophoblast giant cell differentiation|chorionic trophoblast cell differentiation|hepatocyte differentiation|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding|negative regulation of G1/S transition of mitotic cell cycle" E2F E2F8 248.6238804 258.8137719 238.4339888 0.92125696 -0.118324481 0.820386124 1 3.314286854 3.184834037 79733 E2F transcription factor 8 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001217,GO:0001227,GO:0001890,GO:0002040,GO:0003700,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0006977,GO:0008283,GO:0032466,GO:0032877,GO:0033301,GO:0042802,GO:0045944,GO:0060707,GO:0060718,GO:0070365,GO:0090575,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity|DNA-binding transcription repressor activity, RNA polymerase II-specific|placenta development|sprouting angiogenesis|DNA-binding transcription factor activity|protein binding|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell population proliferation|negative regulation of cytokinesis|positive regulation of DNA endoreduplication|cell cycle comprising mitosis without cytokinesis|identical protein binding|positive regulation of transcription by RNA polymerase II|trophoblast giant cell differentiation|chorionic trophoblast cell differentiation|hepatocyte differentiation|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" E2F E4F1 471.5148413 476.0143492 467.0153334 0.981095075 -0.027535145 0.952533945 1 9.366141223 9.584903107 1877 E4F transcription factor 1 "GO:0000122,GO:0000977,GO:0000978,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005654,GO:0005737,GO:0005819,GO:0006260,GO:0006357,GO:0009794,GO:0010564,GO:0016032,GO:0016567,GO:0016740,GO:0035497,GO:0040008,GO:0045944,GO:0046872,GO:0051301,GO:0071850" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytoplasm|spindle|DNA replication|regulation of transcription by RNA polymerase II|regulation of mitotic cell cycle, embryonic|regulation of cell cycle process|viral process|protein ubiquitination|transferase activity|cAMP response element binding|regulation of growth|positive regulation of transcription by RNA polymerase II|metal ion binding|cell division|mitotic cell cycle arrest" EAF1 925.4070084 858.6527492 992.1612675 1.155486043 0.208499834 0.560530235 1 8.844362946 10.65975419 85403 ELL associated factor 1 "GO:0003711,GO:0005515,GO:0005654,GO:0006366,GO:0006368,GO:0008023,GO:0015030,GO:0016604,GO:0016607,GO:0032783,GO:0034243,GO:0043231,GO:0045171" transcription elongation regulator activity|protein binding|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|Cajal body|nuclear body|nuclear speck|super elongation complex|regulation of transcription elongation from RNA polymerase II promoter|intracellular membrane-bounded organelle|intercellular bridge EAF2 25.59930745 32.47859099 18.72002391 0.57638042 -0.794906768 0.451170008 1 0.393711359 0.236702635 55840 ELL associated factor 2 "GO:0003711,GO:0005515,GO:0005654,GO:0006366,GO:0006368,GO:0006915,GO:0008023,GO:0016607,GO:0032783,GO:0034243,GO:0045944" transcription elongation regulator activity|protein binding|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|apoptotic process|transcription elongation factor complex|nuclear speck|super elongation complex|regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription by RNA polymerase II EAPP 552.9273244 552.1360468 553.7186021 1.002866242 0.004129198 0.996937069 1 14.39204475 15.05502368 55837 E2F associated phosphoprotein "GO:0005515,GO:0005634,GO:0005737,GO:0008284,GO:0032968,GO:0034244" protein binding|nucleus|cytoplasm|positive regulation of cell population proliferation|positive regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter EARS2 561.0185184 734.8281211 387.2089157 0.526938075 -0.924294666 0.020566255 0.616714654 6.461189586 3.55130518 124454 "glutamyl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0004818,GO:0005524,GO:0005739,GO:0005759,GO:0006424,GO:0008270,GO:0050561,GO:0070127" tRNA binding|glutamate-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|glutamyl-tRNA aminoacylation|zinc ion binding|glutamate-tRNA(Gln) ligase activity|tRNA aminoacylation for mitochondrial protein translation "hsa00860,hsa00970" Porphyrin and chlorophyll metabolism|Aminoacyl-tRNA biosynthesis EBAG9 372.67936 421.2067269 324.151993 0.769579336 -0.377858034 0.394128384 1 7.368785764 5.915143129 9166 estrogen receptor binding site associated antigen 9 "GO:0000139,GO:0001558,GO:0005515,GO:0006915,GO:0016021,GO:0016505,GO:0030141" Golgi membrane|regulation of cell growth|protein binding|apoptotic process|integral component of membrane|peptidase activator activity involved in apoptotic process|secretory granule hsa04915 Estrogen signaling pathway EBF1 12.03101386 14.20938356 9.852644165 0.693389979 -0.528261108 0.729410839 1 0.014491063 0.010480783 1879 EBF transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0007275,GO:0046872,GO:0046983,GO:0070742" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding|protein dimerization activity|C2H2 zinc finger domain binding" COE EBF3 10.3898137 3.044867905 17.7347595 5.824475823 2.542128219 0.086398849 1 0.029328988 0.178184471 253738 EBF transcription factor 3 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0007275,GO:0045893,GO:0046872,GO:0046983" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|positive regulation of transcription, DNA-templated|metal ion binding|protein dimerization activity" COE EBF4 582.1438041 528.7920595 635.4955487 1.201787238 0.265181507 0.501825708 1 8.766432847 10.98920887 57593 EBF family member 4 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0007275,GO:0046872,GO:0046983" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding|protein dimerization activity" EBI3 48.33189631 71.04691779 25.61687483 0.360562789 -1.47167758 0.089417652 1 2.594286768 0.975696652 10148 Epstein-Barr virus induced 3 "GO:0004896,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006959,GO:0009897,GO:0017046,GO:0019221,GO:0019955,GO:0032729,GO:0033210,GO:0042088,GO:0043235,GO:0046641,GO:0070106,GO:0070757" cytokine receptor activity|cytokine activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|humoral immune response|external side of plasma membrane|peptide hormone binding|cytokine-mediated signaling pathway|cytokine binding|positive regulation of interferon-gamma production|leptin-mediated signaling pathway|T-helper 1 type immune response|receptor complex|positive regulation of alpha-beta T cell proliferation|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway hsa04060 Cytokine-cytokine receptor interaction EBLN2 44.99011288 44.65806261 45.32216316 1.014870787 0.021296056 1 1 1.34709549 1.426018184 55096 endogenous Bornavirus like nucleoprotein 2 EBNA1BP2 1477.570271 1627.989373 1327.151169 0.815208742 -0.294758572 0.375039208 1 50.21432311 42.69847565 10969 EBNA1 binding protein 2 "GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0006364,GO:0030687,GO:0034399,GO:0042273" "RNA binding|protein binding|chromosome|nucleolus|rRNA processing|preribosome, large subunit precursor|nuclear periphery|ribosomal large subunit biogenesis" EBP 1351.543025 1297.113728 1405.972322 1.083923709 0.116263217 0.730786178 1 58.39487499 66.02210676 10682 EBP cholestenol delta-isomerase "GO:0000247,GO:0001501,GO:0004769,GO:0004888,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005887,GO:0006695,GO:0008203,GO:0016126,GO:0031410,GO:0033489,GO:0033490,GO:0042802,GO:0042908,GO:0042910,GO:0047750" C-8 sterol isomerase activity|skeletal system development|steroid delta-isomerase activity|transmembrane signaling receptor activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|cholesterol biosynthetic process|cholesterol metabolic process|sterol biosynthetic process|cytoplasmic vesicle|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|identical protein binding|xenobiotic transport|xenobiotic transmembrane transporter activity|cholestenol delta-isomerase activity hsa00100 Steroid biosynthesis EBPL 436.2680089 491.2386887 381.2973292 0.776195642 -0.365507762 0.388661585 1 23.9226025 19.36848063 84650 EBP like "GO:0005783,GO:0005789,GO:0016021,GO:0016125,GO:0047750" endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|sterol metabolic process|cholestenol delta-isomerase activity ECD 1621.668533 1678.737172 1564.599893 0.932010037 -0.101582603 0.758382945 1 26.6360011 25.89438157 11319 ecdysoneless cell cycle regulator "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0008380,GO:0035035,GO:0045944" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|RNA splicing|histone acetyltransferase binding|positive regulation of transcription by RNA polymerase II ECE1 12758.5052 15581.60403 9935.406376 0.637636944 -0.649192875 0.060223098 1 114.6525171 76.25581997 1889 endothelin converting enzyme 1 "GO:0001921,GO:0003100,GO:0004175,GO:0004222,GO:0005515,GO:0005765,GO:0005768,GO:0005886,GO:0007507,GO:0008270,GO:0009897,GO:0010814,GO:0010815,GO:0010816,GO:0016020,GO:0016021,GO:0016485,GO:0016486,GO:0017046,GO:0019229,GO:0031302,GO:0031982,GO:0033093,GO:0034959,GO:0042447,GO:0042733,GO:0042803,GO:0043583,GO:0048471,GO:0070062" positive regulation of receptor recycling|regulation of systemic arterial blood pressure by endothelin|endopeptidase activity|metalloendopeptidase activity|protein binding|lysosomal membrane|endosome|plasma membrane|heart development|zinc ion binding|external side of plasma membrane|substance P catabolic process|bradykinin catabolic process|calcitonin catabolic process|membrane|integral component of membrane|protein processing|peptide hormone processing|peptide hormone binding|regulation of vasoconstriction|intrinsic component of endosome membrane|vesicle|Weibel-Palade body|endothelin maturation|hormone catabolic process|embryonic digit morphogenesis|protein homodimerization activity|ear development|perinuclear region of cytoplasm|extracellular exosome ECH1 1098.932066 1237.231325 960.6328061 0.776437507 -0.365058283 0.292705022 1 44.4722512 36.01733294 1891 enoyl-CoA hydratase 1 "GO:0005515,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0016020,GO:0051750,GO:0070062" "protein binding|mitochondrion|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|membrane|delta3,5-delta2,4-dienoyl-CoA isomerase activity|extracellular exosome" hsa04146 Peroxisome ECHDC1 557.0113967 629.2727004 484.7500929 0.770333899 -0.376444181 0.344495154 1 9.384700334 7.540764 55862 ethylmalonyl-CoA decarboxylase 1 "GO:0004300,GO:0005515,GO:0005829,GO:0006635,GO:0016831" enoyl-CoA hydratase activity|protein binding|cytosol|fatty acid beta-oxidation|carboxy-lyase activity hsa00640 Propanoate metabolism ECHDC2 968.8004584 895.1911641 1042.409753 1.164454917 0.219654785 0.536203081 1 6.860080862 8.332356514 55268 enoyl-CoA hydratase domain containing 2 "GO:0004300,GO:0005739,GO:0006635" enoyl-CoA hydratase activity|mitochondrion|fatty acid beta-oxidation ECHS1 1324.345571 1458.491727 1190.199415 0.816048109 -0.293273888 0.384501772 1 57.84452678 49.23726998 1892 "enoyl-CoA hydratase, short chain 1" "GO:0004300,GO:0005515,GO:0005739,GO:0005759,GO:0006635" enoyl-CoA hydratase activity|protein binding|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation "hsa00062,hsa00071,hsa00280,hsa00310,hsa00380,hsa00410,hsa00640,hsa00650" "Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism" ECI1 544.3568602 572.4351662 516.2785543 0.901898739 -0.148962632 0.712522541 1 19.23810334 18.09822414 1632 enoyl-CoA delta isomerase 1 "GO:0004165,GO:0004300,GO:0005739,GO:0005759,GO:0006635,GO:0016863" "dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|intramolecular oxidoreductase activity, transposing C=C bonds" hsa00071 Fatty acid degradation ECI2 596.1196146 675.9606749 516.2785543 0.763770103 -0.388789647 0.321031429 1 23.28913166 18.55375768 10455 enoyl-CoA delta isomerase 2 "GO:0000062,GO:0004165,GO:0005515,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0016020,GO:0033540,GO:0043231" fatty-acyl-CoA binding|dodecenoyl-CoA delta-isomerase activity|protein binding|mitochondrion|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|membrane|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular membrane-bounded organelle "hsa00071,hsa04146" Fatty acid degradation|Peroxisome ECM1 174.843856 131.9442759 217.7434361 1.65026815 0.722700465 0.200107208 1 3.141754632 5.408075073 1893 extracellular matrix protein 1 "GO:0001503,GO:0001525,GO:0001938,GO:0001960,GO:0002020,GO:0002063,GO:0002576,GO:0002828,GO:0003416,GO:0005134,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0006357,GO:0006954,GO:0007165,GO:0008022,GO:0010466,GO:0019899,GO:0030500,GO:0030502,GO:0031012,GO:0031089,GO:0031214,GO:0043123,GO:0043236,GO:0045766,GO:0062023,GO:0070062,GO:2000404" ossification|angiogenesis|positive regulation of endothelial cell proliferation|negative regulation of cytokine-mediated signaling pathway|protease binding|chondrocyte development|platelet degranulation|regulation of type 2 immune response|endochondral bone growth|interleukin-2 receptor binding|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|regulation of transcription by RNA polymerase II|inflammatory response|signal transduction|protein C-terminus binding|negative regulation of peptidase activity|enzyme binding|regulation of bone mineralization|negative regulation of bone mineralization|extracellular matrix|platelet dense granule lumen|biomineral tissue development|positive regulation of I-kappaB kinase/NF-kappaB signaling|laminin binding|positive regulation of angiogenesis|collagen-containing extracellular matrix|extracellular exosome|regulation of T cell migration ECPAS 3560.740419 3738.082832 3383.398006 0.905115847 -0.143825639 0.65157691 1 22.4340216 21.18006223 23392 Ecm29 proteasome adaptor and scaffold "GO:0000502,GO:0005515,GO:0005634,GO:0005654,GO:0005769,GO:0005770,GO:0005771,GO:0005783,GO:0005793,GO:0005802,GO:0005813,GO:0016020,GO:0030134,GO:0030139,GO:0030433,GO:0031410,GO:0043248,GO:0060090,GO:0070628" proteasome complex|protein binding|nucleus|nucleoplasm|early endosome|late endosome|multivesicular body|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|trans-Golgi network|centrosome|membrane|COPII-coated ER to Golgi transport vesicle|endocytic vesicle|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|proteasome assembly|molecular adaptor activity|proteasome binding ECSIT 315.0968153 290.277407 339.9162237 1.171004755 0.227746934 0.628120245 1 8.926245674 10.90293502 51295 ECSIT signaling integrator "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005829,GO:0032981,GO:0045087,GO:0051341,GO:0061635" protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|cytosol|mitochondrial respiratory chain complex I assembly|innate immune response|regulation of oxidoreductase activity|regulation of protein complex stability hsa04010 MAPK signaling pathway ECT2 2610.540227 2295.8304 2925.250053 1.274157731 0.349543883 0.272992324 1 21.34674327 28.37074565 1894 epithelial cell transforming 2 "GO:0000281,GO:0000902,GO:0005085,GO:0005096,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005911,GO:0005923,GO:0005938,GO:0007186,GO:0007399,GO:0015031,GO:0016604,GO:0030154,GO:0030496,GO:0031267,GO:0032147,GO:0032154,GO:0032467,GO:0035556,GO:0042307,GO:0042803,GO:0043065,GO:0043123,GO:0043547,GO:0045666,GO:0045859,GO:0051056,GO:0051260,GO:0051988,GO:0070301,GO:0070830,GO:0071277,GO:0071479,GO:0072686,GO:0090630,GO:0097149,GO:2000431" "mitotic cytokinesis|cell morphogenesis|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell-cell junction|bicellular tight junction|cell cortex|G protein-coupled receptor signaling pathway|nervous system development|protein transport|nuclear body|cell differentiation|midbody|small GTPase binding|activation of protein kinase activity|cleavage furrow|positive regulation of cytokinesis|intracellular signal transduction|positive regulation of protein import into nucleus|protein homodimerization activity|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of GTPase activity|positive regulation of neuron differentiation|regulation of protein kinase activity|regulation of small GTPase mediated signal transduction|protein homooligomerization|regulation of attachment of spindle microtubules to kinetochore|cellular response to hydrogen peroxide|bicellular tight junction assembly|cellular response to calcium ion|cellular response to ionizing radiation|mitotic spindle|activation of GTPase activity|centralspindlin complex|regulation of cytokinesis, actomyosin contractile ring assembly" EDA 39.3187804 27.40381115 51.23374966 1.869584832 0.902717935 0.326011146 1 0.121532956 0.237003723 1896 ectodysplasin A "GO:0005102,GO:0005123,GO:0005164,GO:0005515,GO:0005576,GO:0005581,GO:0005789,GO:0005811,GO:0005856,GO:0005886,GO:0005887,GO:0006955,GO:0007160,GO:0010467,GO:0010628,GO:0016020,GO:0016021,GO:0030154,GO:0033209,GO:0038177,GO:0042475,GO:0043123,GO:0043231,GO:0043473,GO:0045177,GO:0051092,GO:0060662,GO:0060789,GO:0061153,GO:0090263,GO:1901224" signaling receptor binding|death receptor binding|tumor necrosis factor receptor binding|protein binding|extracellular region|collagen trimer|endoplasmic reticulum membrane|lipid droplet|cytoskeleton|plasma membrane|integral component of plasma membrane|immune response|cell-matrix adhesion|gene expression|positive regulation of gene expression|membrane|integral component of membrane|cell differentiation|tumor necrosis factor-mediated signaling pathway|death receptor agonist activity|odontogenesis of dentin-containing tooth|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|pigmentation|apical part of cell|positive regulation of NF-kappaB transcription factor activity|salivary gland cavitation|hair follicle placode formation|trachea gland development|positive regulation of canonical Wnt signaling pathway|positive regulation of NIK/NF-kappaB signaling "hsa04060,hsa04064" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway EDARADD 257.8826935 218.2155332 297.5498538 1.363559456 0.447377608 0.368413098 1 3.333890479 4.741779318 128178 EDAR associated death domain "GO:0005515,GO:0005829,GO:0007275,GO:0030154,GO:0033209,GO:1901224" protein binding|cytosol|multicellular organism development|cell differentiation|tumor necrosis factor-mediated signaling pathway|positive regulation of NIK/NF-kappaB signaling hsa04064 NF-kappa B signaling pathway EDC3 1690.803067 1656.40814 1725.197993 1.041529531 0.058703745 0.859106713 1 16.87612731 18.33413019 80153 enhancer of mRNA decapping 3 "GO:0000932,GO:0003729,GO:0005515,GO:0005829,GO:0016020,GO:0031087,GO:0033962,GO:0036464,GO:0042802,GO:0043928,GO:0090502,GO:1990174" "P-body|mRNA binding|protein binding|cytosol|membrane|deadenylation-independent decapping of nuclear-transcribed mRNA|P-body assembly|cytoplasmic ribonucleoprotein granule|identical protein binding|exonucleolytic catabolism of deadenylated mRNA|RNA phosphodiester bond hydrolysis, endonucleolytic|phosphodiesterase decapping endonuclease activity" hsa03018 RNA degradation EDC4 1475.17342 1363.085866 1587.260975 1.164461473 0.219662908 0.508976027 1 14.48195729 17.59010032 23644 enhancer of mRNA decapping 4 "GO:0000932,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008150,GO:0016020,GO:0031087,GO:0036464,GO:0043928" P-body|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|biological_process|membrane|deadenylation-independent decapping of nuclear-transcribed mRNA|cytoplasmic ribonucleoprotein granule|exonucleolytic catabolism of deadenylated mRNA hsa03018 RNA degradation EDEM1 3592.407935 3680.230341 3504.58553 0.952273419 -0.070552232 0.82517747 1 26.42714926 26.24991547 9695 ER degradation enhancing alpha-mannosidase like protein 1 "GO:0004571,GO:0005509,GO:0005515,GO:0005783,GO:0005975,GO:0016235,GO:0030176,GO:0030433,GO:0036498,GO:0036510,GO:0044322,GO:0045047,GO:0051787,GO:0097466,GO:1904154,GO:1904382" "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|protein binding|endoplasmic reticulum|carbohydrate metabolic process|aggresome|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|IRE1-mediated unfolded protein response|trimming of terminal mannose on C branch|endoplasmic reticulum quality control compartment|protein targeting to ER|misfolded protein binding|ubiquitin-dependent glycoprotein ERAD pathway|positive regulation of retrograde protein transport, ER to cytosol|mannose trimming involved in glycoprotein ERAD pathway" hsa04141 Protein processing in endoplasmic reticulum EDEM2 42.70510115 56.83753423 28.57266808 0.502707735 -0.992208208 0.267202304 1 1.527930254 0.801189091 55741 ER degradation enhancing alpha-mannosidase like protein 2 "GO:0004571,GO:0005509,GO:0005783,GO:0005788,GO:0005975,GO:0006986,GO:0016020,GO:0036509,GO:0036510,GO:0036511,GO:0036512,GO:0044322,GO:0097466,GO:1904154,GO:1904382" "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum lumen|carbohydrate metabolic process|response to unfolded protein|membrane|trimming of terminal mannose on B branch|trimming of terminal mannose on C branch|trimming of first mannose on A branch|trimming of second mannose on A branch|endoplasmic reticulum quality control compartment|ubiquitin-dependent glycoprotein ERAD pathway|positive regulation of retrograde protein transport, ER to cytosol|mannose trimming involved in glycoprotein ERAD pathway" hsa04141 Protein processing in endoplasmic reticulum EDEM3 1335.554624 1483.865626 1187.243622 0.800101843 -0.321744446 0.339410587 1 8.661122413 7.228286823 80267 ER degradation enhancing alpha-mannosidase like protein 3 "GO:0004571,GO:0005509,GO:0005788,GO:0005975,GO:0006486,GO:0006986,GO:0016020,GO:0044322,GO:1904382" "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum lumen|carbohydrate metabolic process|protein glycosylation|response to unfolded protein|membrane|endoplasmic reticulum quality control compartment|mannose trimming involved in glycoprotein ERAD pathway" hsa04141 Protein processing in endoplasmic reticulum EDF1 3282.473737 3237.709539 3327.237935 1.027651769 0.039351474 0.90242115 1 156.170063 167.4016327 8721 endothelial differentiation related factor 1 "GO:0001094,GO:0003677,GO:0003713,GO:0003723,GO:0005515,GO:0005516,GO:0005622,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006355,GO:0007275,GO:0019216,GO:0043388,GO:0045446,GO:0045893" "TFIID-class transcription factor complex binding|DNA binding|transcription coactivator activity|RNA binding|protein binding|calmodulin binding|intracellular anatomical structure|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of transcription, DNA-templated|multicellular organism development|regulation of lipid metabolic process|positive regulation of DNA binding|endothelial cell differentiation|positive regulation of transcription, DNA-templated" EDIL3 172.2295156 155.2882632 189.170768 1.218191022 0.284740377 0.619818923 1 1.63815928 2.081552891 10085 EGF like repeats and discoidin domains 3 "GO:0005178,GO:0005201,GO:0005509,GO:0007155,GO:0007275,GO:0010811,GO:0062023,GO:0070062,GO:1903561" integrin binding|extracellular matrix structural constituent|calcium ion binding|cell adhesion|multicellular organism development|positive regulation of cell-substrate adhesion|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle EDN1 36.10788736 43.64310664 28.57266808 0.654689143 -0.611118041 0.523020943 1 0.83441653 0.569815118 1906 endothelin 1 "GO:0000122,GO:0001516,GO:0001569,GO:0001701,GO:0001821,GO:0003100,GO:0005125,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0006874,GO:0006885,GO:0007166,GO:0007186,GO:0007193,GO:0007204,GO:0007205,GO:0007267,GO:0007507,GO:0007585,GO:0007589,GO:0008284,GO:0009953,GO:0010193,GO:0010259,GO:0010460,GO:0010595,GO:0010613,GO:0010827,GO:0014032,GO:0014065,GO:0014823,GO:0014824,GO:0014826,GO:0019229,GO:0019233,GO:0019722,GO:0030072,GO:0030133,GO:0030185,GO:0030195,GO:0030335,GO:0030593,GO:0031583,GO:0031707,GO:0031708,GO:0032269,GO:0032308,GO:0032496,GO:0033093,GO:0033574,GO:0034392,GO:0034696,GO:0035094,GO:0035690,GO:0035810,GO:0035815,GO:0035994,GO:0042045,GO:0042310,GO:0042313,GO:0042474,GO:0042482,GO:0042554,GO:0043179,GO:0043200,GO:0043406,GO:0043507,GO:0044321,GO:0045178,GO:0045321,GO:0045429,GO:0045793,GO:0045840,GO:0045944,GO:0045987,GO:0046887,GO:0046888,GO:0048016,GO:0048237,GO:0048661,GO:0051091,GO:0051216,GO:0051482,GO:0051771,GO:0051899,GO:0051930,GO:0060137,GO:0060298,GO:0060585,GO:0061051,GO:0070101,GO:0071277,GO:0071346,GO:0071347,GO:0071356,GO:0071375,GO:0071385,GO:0071389,GO:0071398,GO:0071456,GO:0071548,GO:0071560,GO:0086100,GO:0090023,GO:1901224,GO:1902074,GO:1904707,GO:2000273" negative regulation of transcription by RNA polymerase II|prostaglandin biosynthetic process|branching involved in blood vessel morphogenesis|in utero embryonic development|histamine secretion|regulation of systemic arterial blood pressure by endothelin|cytokine activity|hormone activity|protein binding|extracellular region|extracellular space|cytoplasm|cellular calcium ion homeostasis|regulation of pH|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G protein-coupled receptor signaling pathway|cell-cell signaling|heart development|respiratory gaseous exchange by respiratory system|body fluid secretion|positive regulation of cell population proliferation|dorsal/ventral pattern formation|response to ozone|multicellular organism aging|positive regulation of heart rate|positive regulation of endothelial cell migration|positive regulation of cardiac muscle hypertrophy|regulation of glucose transmembrane transport|neural crest cell development|phosphatidylinositol 3-kinase signaling|response to activity|artery smooth muscle contraction|vein smooth muscle contraction|regulation of vasoconstriction|sensory perception of pain|calcium-mediated signaling|peptide hormone secretion|transport vesicle|nitric oxide transport|negative regulation of blood coagulation|positive regulation of cell migration|neutrophil chemotaxis|phospholipase D-activating G protein-coupled receptor signaling pathway|endothelin A receptor binding|endothelin B receptor binding|negative regulation of cellular protein metabolic process|positive regulation of prostaglandin secretion|response to lipopolysaccharide|Weibel-Palade body|response to testosterone|negative regulation of smooth muscle cell apoptotic process|response to prostaglandin F|response to nicotine|cellular response to drug|positive regulation of urine volume|positive regulation of renal sodium excretion|response to muscle stretch|epithelial fluid transport|vasoconstriction|protein kinase C deactivation|middle ear morphogenesis|positive regulation of odontogenesis|superoxide anion generation|rhythmic excitation|response to amino acid|positive regulation of MAP kinase activity|positive regulation of JUN kinase activity|response to leptin|basal part of cell|leukocyte activation|positive regulation of nitric oxide biosynthetic process|positive regulation of cell size|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle contraction|positive regulation of hormone secretion|negative regulation of hormone secretion|inositol phosphate-mediated signaling|rough endoplasmic reticulum lumen|positive regulation of smooth muscle cell proliferation|positive regulation of DNA-binding transcription factor activity|cartilage development|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|negative regulation of nitric-oxide synthase biosynthetic process|membrane depolarization|regulation of sensory perception of pain|maternal process involved in parturition|positive regulation of sarcomere organization|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of cell growth involved in cardiac muscle cell development|positive regulation of chemokine-mediated signaling pathway|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to peptide hormone stimulus|cellular response to glucocorticoid stimulus|cellular response to mineralocorticoid stimulus|cellular response to fatty acid|cellular response to hypoxia|response to dexamethasone|cellular response to transforming growth factor beta stimulus|endothelin receptor signaling pathway|positive regulation of neutrophil chemotaxis|positive regulation of NIK/NF-kappaB signaling|response to salt|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of signaling receptor activity "hsa04024,hsa04066,hsa04080,hsa04270,hsa04668,hsa04916,hsa04924,hsa04926,hsa04933,hsa05200,hsa05410,hsa05418" cAMP signaling pathway|HIF-1 signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|TNF signaling pathway|Melanogenesis|Renin secretion|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer|Hypertrophic cardiomyopathy|Fluid shear stress and atherosclerosis EDNRA 71.69072936 118.7498483 24.63161041 0.207424353 -2.269342811 0.004110009 0.236073713 1.197106069 0.259005094 1909 endothelin receptor type A "GO:0001569,GO:0001666,GO:0001701,GO:0004435,GO:0004962,GO:0005515,GO:0005886,GO:0005887,GO:0006939,GO:0007165,GO:0007186,GO:0007190,GO:0007193,GO:0007202,GO:0007204,GO:0007507,GO:0007585,GO:0008217,GO:0008283,GO:0010827,GO:0014032,GO:0014824,GO:0042310,GO:0048484,GO:0060322,GO:0086100" branching involved in blood vessel morphogenesis|response to hypoxia|in utero embryonic development|phosphatidylinositol phospholipase C activity|endothelin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|smooth muscle contraction|signal transduction|G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|heart development|respiratory gaseous exchange by respiratory system|regulation of blood pressure|cell population proliferation|regulation of glucose transmembrane transport|neural crest cell development|artery smooth muscle contraction|vasoconstriction|enteric nervous system development|head development|endothelin receptor signaling pathway "hsa04020,hsa04022,hsa04024,hsa04080,hsa04270,hsa04924,hsa05200" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Renin secretion|Pathways in cancer EDRF1 382.2202428 399.8926515 364.5478341 0.911614236 -0.13350464 0.765561951 1 4.453199662 4.234471322 26098 erythroid differentiation regulatory factor 1 "GO:0005515,GO:0005575,GO:0005634,GO:0045893" "protein binding|cellular_component|nucleus|positive regulation of transcription, DNA-templated" EEA1 945.9894352 1087.017842 804.9610283 0.74052237 -0.433384778 0.223394955 1 5.427210069 4.192091409 8411 early endosome antigen 1 "GO:0005515,GO:0005516,GO:0005545,GO:0005737,GO:0005769,GO:0005829,GO:0005969,GO:0006897,GO:0006906,GO:0008270,GO:0016020,GO:0016189,GO:0019897,GO:0030742,GO:0031901,GO:0039694,GO:0042803,GO:0044308,GO:0045022,GO:0055037,GO:0070062" protein binding|calmodulin binding|1-phosphatidylinositol binding|cytoplasm|early endosome|cytosol|serine-pyruvate aminotransferase complex|endocytosis|vesicle fusion|zinc ion binding|membrane|synaptic vesicle to endosome fusion|extrinsic component of plasma membrane|GTP-dependent protein binding|early endosome membrane|viral RNA genome replication|protein homodimerization activity|axonal spine|early endosome to late endosome transport|recycling endosome|extracellular exosome "hsa04144,hsa04145,hsa05152" Endocytosis|Phagosome|Tuberculosis EED 671.1630138 687.1251906 655.200837 0.953539247 -0.068635774 0.860603214 1 10.19345837 10.13855488 8726 embryonic ectoderm development "GO:0000122,GO:0001226,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006342,GO:0016032,GO:0031491,GO:0035098,GO:0042054,GO:0042802,GO:0045814,GO:0045892,GO:0046976,GO:0070317,GO:0070734" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|chromatin silencing|viral process|nucleosome binding|ESC/E(Z) complex|histone methyltransferase activity|identical protein binding|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K27 specific)|negative regulation of G0 to G1 transition|histone H3-K27 methylation" chromosome_remodelling_factor EEF1A1 176612.4077 167375.3738 185849.4416 1.110375065 0.151047076 0.784378184 1 2413.716463 2795.579731 1915 eukaryotic translation elongation factor 1 alpha 1 "GO:0000049,GO:0003723,GO:0003746,GO:0003924,GO:0005515,GO:0005516,GO:0005525,GO:0005576,GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005853,GO:0005886,GO:0006412,GO:0006414,GO:0016020,GO:0019900,GO:0019901,GO:0030864,GO:0032587,GO:0034774,GO:0043312,GO:0070062,GO:0071364,GO:0098574,GO:1900022,GO:1904714,GO:1904813" tRNA binding|RNA binding|translation elongation factor activity|GTPase activity|protein binding|calmodulin binding|GTP binding|extracellular region|extracellular space|nucleus|nucleolus|cytoplasm|cytosol|eukaryotic translation elongation factor 1 complex|plasma membrane|translation|translational elongation|membrane|kinase binding|protein kinase binding|cortical actin cytoskeleton|ruffle membrane|secretory granule lumen|neutrophil degranulation|extracellular exosome|cellular response to epidermal growth factor stimulus|cytoplasmic side of lysosomal membrane|regulation of D-erythro-sphingosine kinase activity|regulation of chaperone-mediated autophagy|ficolin-1-rich granule lumen "hsa03013,hsa05134,hsa05140" RNA transport|Legionellosis|Leishmaniasis EEF1A2 4612.294431 5474.672493 3749.916369 0.684957205 -0.545914241 0.088657634 1 156.3862653 111.7321038 1917 eukaryotic translation elongation factor 1 alpha 2 "GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005853,GO:0006412,GO:0006414,GO:0008135,GO:0010035,GO:0019901,GO:0043025,GO:0043065,GO:0045202,GO:0051602,GO:0090218,GO:0098574,GO:1904714" "translation elongation factor activity|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|eukaryotic translation elongation factor 1 complex|translation|translational elongation|translation factor activity, RNA binding|response to inorganic substance|protein kinase binding|neuronal cell body|positive regulation of apoptotic process|synapse|response to electrical stimulus|positive regulation of lipid kinase activity|cytoplasmic side of lysosomal membrane|regulation of chaperone-mediated autophagy" "hsa03013,hsa05134,hsa05140" RNA transport|Legionellosis|Leishmaniasis EEF1AKMT1 81.26130378 99.4656849 63.05692266 0.633956552 -0.657544125 0.367308449 1 4.014012786 2.65432548 221143 EEF1A lysine methyltransferase 1 "GO:0003676,GO:0005829,GO:0006479,GO:0008168,GO:0016279,GO:0018022" nucleic acid binding|cytosol|protein methylation|methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation EEF1AKMT2 161.4037312 189.7967661 133.0106962 0.700805915 -0.512913144 0.376521265 1 2.667925795 1.950237191 399818 EEF1A lysine methyltransferase 2 "GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006479,GO:0008168,GO:0016279,GO:0016604,GO:0018022,GO:0018026,GO:0018027,GO:0043231" nucleus|nucleoplasm|cytoplasm|cytosol|protein methylation|methyltransferase activity|protein-lysine N-methyltransferase activity|nuclear body|peptidyl-lysine methylation|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|intracellular membrane-bounded organelle EEF1AKMT3 223.7547375 242.5744764 204.9349986 0.844833313 -0.243261371 0.644126567 1 4.347325365 3.830973125 25895 EEF1A lysine methyltransferase 3 "GO:0005515,GO:0005654,GO:0005694,GO:0005737,GO:0005813,GO:0005829,GO:0008168,GO:0016279,GO:0018022,GO:0031072,GO:0032991" protein binding|nucleoplasm|chromosome|cytoplasm|centrosome|cytosol|methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|heat shock protein binding|protein-containing complex EEF1AKMT4 56.31793207 78.15160956 34.48425458 0.441248168 -1.180337805 0.150665026 1 4.059593151 1.868449466 110599564 EEF1A lysine methyltransferase 4 "GO:0008168,GO:0016279,GO:0018022" methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation EEF1AKNMT 926.7619333 1086.002886 767.5209805 0.706739356 -0.500749844 0.161127041 1 18.07499671 13.32457707 51603 eEF1A lysine and N-terminal methyltransferase "GO:0005515,GO:0008168,GO:0032259" protein binding|methyltransferase activity|methylation EEF1B2 5856.278102 6053.197395 5659.358809 0.934937098 -0.09705879 0.764706953 1 346.8021422 338.2050547 1933 eukaryotic translation elongation factor 1 beta 2 "GO:0003746,GO:0005085,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005853,GO:0006414,GO:0050790" translation elongation factor activity|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|eukaryotic translation elongation factor 1 complex|translational elongation|regulation of catalytic activity EEF1D 13053.82471 12532.6763 13574.97313 1.083166341 0.115254814 0.738444489 1 160.4083502 181.2333249 1936 eukaryotic translation elongation factor 1 delta "GO:0001650,GO:0003677,GO:0003746,GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0005853,GO:0006414,GO:0008135,GO:0043123,GO:0045296,GO:0050790,GO:0071479" "fibrillar center|DNA binding|translation elongation factor activity|guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|eukaryotic translation elongation factor 1 complex|translational elongation|translation factor activity, RNA binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|cadherin binding|regulation of catalytic activity|cellular response to ionizing radiation" EEF1E1 573.3155185 598.8240213 547.8070156 0.914804677 -0.128464353 0.748142113 1 25.31579646 24.15660519 9521 eukaryotic translation elongation factor 1 epsilon 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006418,GO:0008285,GO:0017101,GO:0043065,GO:0043517,GO:2000774" "protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|tRNA aminoacylation for protein translation|negative regulation of cell population proliferation|aminoacyl-tRNA synthetase multienzyme complex|positive regulation of apoptotic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of cellular senescence" EEF1G 34956.98542 35114.43164 34799.53919 0.991032392 -0.012995882 0.974158472 1 1229.890793 1271.36523 1937 eukaryotic translation elongation factor 1 gamma "GO:0003746,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0006414,GO:0006749,GO:0009615,GO:0016020,GO:0045296,GO:0070062" translation elongation factor activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|translational elongation|glutathione metabolic process|response to virus|membrane|cadherin binding|extracellular exosome hsa05134 Legionellosis EEF2 59742.75539 56296.5627 63188.94809 1.122429951 0.166625411 0.70584773 1 902.8569659 1057.04659 1938 eukaryotic translation elongation factor 2 "GO:0002039,GO:0002244,GO:0002931,GO:0003009,GO:0003723,GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006414,GO:0007568,GO:0008097,GO:0014009,GO:0016020,GO:0016235,GO:0019901,GO:0032355,GO:0034774,GO:0034976,GO:0035914,GO:0042493,GO:0042542,GO:0042788,GO:0043022,GO:0043312,GO:0045121,GO:0045202,GO:0045296,GO:0045471,GO:0045727,GO:0051015,GO:0051593,GO:0070062,GO:1904813,GO:1990416,GO:1990904,GO:2000767" p53 binding|hematopoietic progenitor cell differentiation|response to ischemia|skeletal muscle contraction|RNA binding|translation elongation factor activity|GTPase activity|protein binding|GTP binding|extracellular region|nucleus|cytoplasm|cytosol|plasma membrane|translational elongation|aging|5S rRNA binding|glial cell proliferation|membrane|aggresome|protein kinase binding|response to estradiol|secretory granule lumen|response to endoplasmic reticulum stress|skeletal muscle cell differentiation|response to drug|response to hydrogen peroxide|polysomal ribosome|ribosome binding|neutrophil degranulation|membrane raft|synapse|cadherin binding|response to ethanol|positive regulation of translation|actin filament binding|response to folic acid|extracellular exosome|ficolin-1-rich granule lumen|cellular response to brain-derived neurotrophic factor stimulus|ribonucleoprotein complex|positive regulation of cytoplasmic translation "hsa04152,hsa04921" AMPK signaling pathway|Oxytocin signaling pathway EEF2K 613.3914334 677.9905869 548.79228 0.80943938 -0.305005056 0.433689302 1 6.348277208 5.359893268 29904 eukaryotic elongation factor 2 kinase "GO:0002931,GO:0004672,GO:0004686,GO:0005509,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0006414,GO:0008135,GO:0014069,GO:0031952,GO:0032869,GO:0043066,GO:0043197,GO:0045807,GO:0046777,GO:0051965,GO:0061003,GO:0071277,GO:0071320,GO:0071454,GO:1990416,GO:1990637" "response to ischemia|protein kinase activity|elongation factor-2 kinase activity|calcium ion binding|calmodulin binding|ATP binding|cytoplasm|cytosol|translational elongation|translation factor activity, RNA binding|postsynaptic density|regulation of protein autophosphorylation|cellular response to insulin stimulus|negative regulation of apoptotic process|dendritic spine|positive regulation of endocytosis|protein autophosphorylation|positive regulation of synapse assembly|positive regulation of dendritic spine morphogenesis|cellular response to calcium ion|cellular response to cAMP|cellular response to anoxia|cellular response to brain-derived neurotrophic factor stimulus|response to prolactin" "hsa04152,hsa04921" AMPK signaling pathway|Oxytocin signaling pathway EEF2KMT 152.1031023 193.85659 110.3496147 0.569233239 -0.812908187 0.168702116 1 3.978181684 2.362059293 196483 eukaryotic elongation factor 2 lysine methyltransferase "GO:0005515,GO:0005737,GO:0005829,GO:0006479,GO:0016279,GO:0018023,GO:0032991" protein binding|cytoplasm|cytosol|protein methylation|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|protein-containing complex EEFSEC 273.4160727 303.4718345 243.3603109 0.801920584 -0.318468724 0.515452604 1 3.781933522 3.16345151 60678 "eukaryotic elongation factor, selenocysteine-tRNA specific" "GO:0000049,GO:0001514,GO:0003746,GO:0003924,GO:0005525,GO:0005634,GO:0005737,GO:0006414,GO:0035368,GO:0043021,GO:1990904" tRNA binding|selenocysteine incorporation|translation elongation factor activity|GTPase activity|GTP binding|nucleus|cytoplasm|translational elongation|selenocysteine insertion sequence binding|ribonucleoprotein complex binding|ribonucleoprotein complex EEPD1 36.00396693 36.53841486 35.469519 0.970745971 -0.042834281 0.997501379 1 0.228857508 0.231732364 80820 endonuclease/exonuclease/phosphatase family domain containing 1 "GO:0003677,GO:0005515,GO:0006281,GO:0010875,GO:0046658" DNA binding|protein binding|DNA repair|positive regulation of cholesterol efflux|anchored component of plasma membrane EFCAB1 15.44974777 12.17947162 18.72002391 1.537014453 0.620130731 0.635142419 1 0.08924295 0.143076333 79645 EF-hand calcium binding domain 1 GO:0005509 calcium ion binding EFCAB11 236.0732644 209.0809295 263.0655992 1.258199874 0.331361123 0.519097495 1 2.222756399 2.917141102 90141 EF-hand calcium binding domain 11 "GO:0005509,GO:0005515" calcium ion binding|protein binding EFCAB12 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.027730242 90288 EF-hand calcium binding domain 12 "GO:0005509,GO:0005515" calcium ion binding|protein binding EFCAB13 17.13548526 26.38885518 7.882115332 0.298691068 -1.743273999 0.143408453 1 0.283999664 0.088482216 124989 EF-hand calcium binding domain 13 EFCAB14 2656.284752 2425.744764 2886.82474 1.190077696 0.251055765 0.43093214 1 21.12006443 26.2172107 9813 EF-hand calcium binding domain 14 GO:0005509 calcium ion binding EFCAB2 93.68375102 73.07682972 114.2906723 1.563979619 0.645221712 0.353680888 1 0.266879408 0.435373593 84288 EF-hand calcium binding domain 2 "GO:0005509,GO:0005737,GO:0005856,GO:0031514" calcium ion binding|cytoplasm|cytoskeleton|motile cilium EFCAB5 7.971189988 6.08973581 9.852644165 1.617909951 0.694131313 0.702268135 1 0.046716697 0.078839236 374786 EF-hand calcium binding domain 5 GO:0005509 calcium ion binding EFCAB6 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.022427548 0.015139518 64800 EF-hand calcium binding domain 6 "GO:0005509,GO:0005654" calcium ion binding|nucleoplasm EFCAB7 162.1987221 143.1087915 181.2886526 1.266789068 0.341176322 0.558588586 1 1.499680413 1.981613516 84455 EF-hand calcium binding domain 7 "GO:0005509,GO:0005929,GO:0019898,GO:0042307,GO:0045944,GO:0060170,GO:0098797,GO:1903569" calcium ion binding|cilium|extrinsic component of membrane|positive regulation of protein import into nucleus|positive regulation of transcription by RNA polymerase II|ciliary membrane|plasma membrane protein complex|positive regulation of protein localization to ciliary membrane EFCAB8 35.49648894 35.52345889 35.469519 0.99848157 -0.002192297 1 1 0.184963285 0.192637801 388795 EF-hand calcium binding domain 8 GO:0005509 calcium ion binding EFEMP1 1702.352089 1907.102265 1497.601913 0.785276144 -0.348728024 0.286033978 1 32.11037295 26.30169177 2202 EGF containing fibulin extracellular matrix protein 1 "GO:0005006,GO:0005154,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006355,GO:0007173,GO:0007601,GO:0008083,GO:0018108,GO:0031012,GO:0032331,GO:0043010,GO:0048048,GO:0048050,GO:0062023,GO:0070062" "epidermal growth factor-activated receptor activity|epidermal growth factor receptor binding|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|extracellular space|regulation of transcription, DNA-templated|epidermal growth factor receptor signaling pathway|visual perception|growth factor activity|peptidyl-tyrosine phosphorylation|extracellular matrix|negative regulation of chondrocyte differentiation|camera-type eye development|embryonic eye morphogenesis|post-embryonic eye morphogenesis|collagen-containing extracellular matrix|extracellular exosome" EFEMP2 2043.216958 2174.035684 1912.398233 0.879653562 -0.184992643 0.565803469 1 56.93238773 52.23805442 30008 EGF containing fibulin extracellular matrix protein 2 "GO:0001527,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0008201,GO:0031012,GO:0035904,GO:0042803,GO:0048251,GO:0060414,GO:0062023,GO:0070062,GO:0071953,GO:0097084,GO:1903561,GO:1904026,GO:1904028,GO:1904706,GO:1904831,GO:1905609" microfibril|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|basement membrane|heparin binding|extracellular matrix|aorta development|protein homodimerization activity|elastic fiber assembly|aorta smooth muscle tissue morphogenesis|collagen-containing extracellular matrix|extracellular exosome|elastic fiber|vascular associated smooth muscle cell development|extracellular vesicle|regulation of collagen fibril organization|positive regulation of collagen fibril organization|negative regulation of vascular associated smooth muscle cell proliferation|positive regulation of aortic smooth muscle cell differentiation|positive regulation of smooth muscle cell-matrix adhesion EFHB 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.058413567 0.044360509 151651 EF-hand domain family member B "GO:0005515,GO:0005737,GO:0006816,GO:0032091,GO:0061891,GO:0070884,GO:2001256" protein binding|cytoplasm|calcium ion transport|negative regulation of protein binding|calcium ion sensor activity|regulation of calcineurin-NFAT signaling cascade|regulation of store-operated calcium entry EFHC1 634.6394447 615.0633168 654.2155726 1.063655651 0.089031167 0.820933359 1 4.426085136 4.910624709 114327 EF-hand domain containing 1 "GO:0000281,GO:0000922,GO:0005509,GO:0005515,GO:0005813,GO:0005930,GO:0007052,GO:0008022,GO:0021795,GO:0043014,GO:0043025,GO:0051302,GO:0060285,GO:0072686" mitotic cytokinesis|spindle pole|calcium ion binding|protein binding|centrosome|axoneme|mitotic spindle organization|protein C-terminus binding|cerebral cortex cell migration|alpha-tubulin binding|neuronal cell body|regulation of cell division|cilium-dependent cell motility|mitotic spindle EFHC2 8.493513748 8.119647747 8.867379749 1.092089217 0.12709072 1 1 0.081983954 0.093390545 80258 EF-hand domain containing 2 "GO:0000281,GO:0005509,GO:0005515,GO:0005874,GO:0005930,GO:0007052,GO:0010975,GO:0036064,GO:0043014,GO:0060285,GO:0072686,GO:1990830" mitotic cytokinesis|calcium ion binding|protein binding|microtubule|axoneme|mitotic spindle organization|regulation of neuron projection development|ciliary basal body|alpha-tubulin binding|cilium-dependent cell motility|mitotic spindle|cellular response to leukemia inhibitory factor EFHD2 2521.115237 3456.940028 1585.290446 0.458581993 -1.12474839 0.000486708 0.054973644 72.28811605 34.57799707 79180 EF-hand domain family member D2 "GO:0005509,GO:0045121,GO:0045296" calcium ion binding|membrane raft|cadherin binding EFL1 1613.484305 1354.966218 1872.002391 1.381586025 0.466325395 0.156245488 1 16.61202104 23.93956936 79631 elongation factor like GTPase 1 "GO:0003746,GO:0003924,GO:0005525,GO:0005829,GO:0006414,GO:0042256,GO:0043022,GO:0046039,GO:1990904" translation elongation factor activity|GTPase activity|GTP binding|cytosol|translational elongation|mature ribosome assembly|ribosome binding|GTP metabolic process|ribonucleoprotein complex hsa03008 Ribosome biogenesis in eukaryotes EFNA1 1315.626403 1839.100215 792.1525909 0.430728345 -1.21514983 0.000374289 0.044894865 60.01542392 26.96387218 1942 ephrin A1 "GO:0000122,GO:0001525,GO:0001934,GO:0003180,GO:0003183,GO:0003199,GO:0005102,GO:0005515,GO:0005576,GO:0005886,GO:0007267,GO:0007411,GO:0010719,GO:0014028,GO:0016477,GO:0033628,GO:0034446,GO:0043409,GO:0043410,GO:0043535,GO:0045765,GO:0046658,GO:0046875,GO:0048013,GO:0050730,GO:0050731,GO:0050770,GO:0050821,GO:0061002,GO:0061098,GO:0070244,GO:1902004,GO:1902961,GO:1903051" negative regulation of transcription by RNA polymerase II|angiogenesis|positive regulation of protein phosphorylation|aortic valve morphogenesis|mitral valve morphogenesis|endocardial cushion to mesenchymal transition involved in heart valve formation|signaling receptor binding|protein binding|extracellular region|plasma membrane|cell-cell signaling|axon guidance|negative regulation of epithelial to mesenchymal transition|notochord formation|cell migration|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading|negative regulation of MAPK cascade|positive regulation of MAPK cascade|regulation of blood vessel endothelial cell migration|regulation of angiogenesis|anchored component of plasma membrane|ephrin receptor binding|ephrin receptor signaling pathway|regulation of peptidyl-tyrosine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of axonogenesis|protein stabilization|negative regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|negative regulation of thymocyte apoptotic process|positive regulation of amyloid-beta formation|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of proteolysis involved in cellular protein catabolic process "hsa04010,hsa04014,hsa04015,hsa04151,hsa04360,hsa05206" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance|MicroRNAs in cancer EFNA3 144.4139821 207.0510175 81.77694657 0.39496037 -1.340220192 0.027089166 0.726163375 5.771273311 2.377612596 1944 ephrin A3 "GO:0005005,GO:0005515,GO:0005886,GO:0007267,GO:0007411,GO:0016525,GO:0031225,GO:0031226,GO:0045664,GO:0046875,GO:0048013,GO:1902961" transmembrane-ephrin receptor activity|protein binding|plasma membrane|cell-cell signaling|axon guidance|negative regulation of angiogenesis|anchored component of membrane|intrinsic component of plasma membrane|regulation of neuron differentiation|ephrin receptor binding|ephrin receptor signaling pathway|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process "hsa04010,hsa04014,hsa04015,hsa04151,hsa04360,hsa05206" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance|MicroRNAs in cancer EFNA4 211.5901117 219.2304892 203.9497342 0.930298222 -0.104234826 0.851797885 1 8.854267048 8.591930133 1945 ephrin A4 "GO:0005005,GO:0005515,GO:0005576,GO:0005886,GO:0007267,GO:0007411,GO:0031225,GO:0031226,GO:0046875,GO:0048013" transmembrane-ephrin receptor activity|protein binding|extracellular region|plasma membrane|cell-cell signaling|axon guidance|anchored component of membrane|intrinsic component of plasma membrane|ephrin receptor binding|ephrin receptor signaling pathway "hsa04010,hsa04014,hsa04015,hsa04151,hsa04360,hsa05206" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance|MicroRNAs in cancer EFNA5 322.8722886 316.6662621 329.0783151 1.039196007 0.055467792 0.911156019 1 1.817340402 1.969924949 1946 ephrin A5 "GO:0001934,GO:0005168,GO:0005169,GO:0005170,GO:0005515,GO:0005886,GO:0005901,GO:0006915,GO:0007171,GO:0007399,GO:0007411,GO:0022407,GO:0022604,GO:0030297,GO:0031362,GO:0032956,GO:0043087,GO:0046875,GO:0048013,GO:0050731,GO:0051893,GO:0061178,GO:0070507,GO:1900025" positive regulation of protein phosphorylation|neurotrophin TRKA receptor binding|neurotrophin TRKB receptor binding|neurotrophin TRKC receptor binding|protein binding|plasma membrane|caveola|apoptotic process|activation of transmembrane receptor protein tyrosine kinase activity|nervous system development|axon guidance|regulation of cell-cell adhesion|regulation of cell morphogenesis|transmembrane receptor protein tyrosine kinase activator activity|anchored component of external side of plasma membrane|regulation of actin cytoskeleton organization|regulation of GTPase activity|ephrin receptor binding|ephrin receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|regulation of focal adhesion assembly|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of microtubule cytoskeleton organization|negative regulation of substrate adhesion-dependent cell spreading "hsa04010,hsa04014,hsa04015,hsa04151,hsa04360,hsa05206" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance|MicroRNAs in cancer EFNB1 182.3911994 210.0958855 154.6865134 0.736266267 -0.44170049 0.428373497 1 3.22150028 2.474053043 1947 ephrin B1 "GO:0001755,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0007155,GO:0007267,GO:0007411,GO:0009880,GO:0031295,GO:0042102,GO:0045121,GO:0045202,GO:0046875,GO:0048013,GO:0070062" neural crest cell migration|protein binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|cell adhesion|cell-cell signaling|axon guidance|embryonic pattern specification|T cell costimulation|positive regulation of T cell proliferation|membrane raft|synapse|ephrin receptor binding|ephrin receptor signaling pathway|extracellular exosome hsa04360 Axon guidance EFNB2 510.7066907 595.7791534 425.6342279 0.714416115 -0.485163472 0.232778838 1 2.085143552 1.553828673 1948 ephrin B2 "GO:0001618,GO:0002042,GO:0005515,GO:0005886,GO:0005887,GO:0005912,GO:0005925,GO:0007155,GO:0007267,GO:0007411,GO:0008284,GO:0009653,GO:0010977,GO:0046718,GO:0046875,GO:0048013,GO:0048514,GO:0050920,GO:0098978,GO:0099054,GO:0099056,GO:1901216,GO:2000727" virus receptor activity|cell migration involved in sprouting angiogenesis|protein binding|plasma membrane|integral component of plasma membrane|adherens junction|focal adhesion|cell adhesion|cell-cell signaling|axon guidance|positive regulation of cell population proliferation|anatomical structure morphogenesis|negative regulation of neuron projection development|viral entry into host cell|ephrin receptor binding|ephrin receptor signaling pathway|blood vessel morphogenesis|regulation of chemotaxis|glutamatergic synapse|presynapse assembly|integral component of presynaptic membrane|positive regulation of neuron death|positive regulation of cardiac muscle cell differentiation hsa04360 Axon guidance EFNB3 699.4914685 569.3902983 829.5926387 1.456984148 0.542985181 0.150882914 1 8.966918507 13.62743061 1949 ephrin B3 "GO:0001618,GO:0005005,GO:0005515,GO:0005886,GO:0005887,GO:0007267,GO:0007399,GO:0007411,GO:0007628,GO:0016198,GO:0031295,GO:0046718,GO:0046875,GO:0048013,GO:0050771,GO:0098686,GO:0098978,GO:0099056,GO:0099061,GO:0099557" "virus receptor activity|transmembrane-ephrin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell-cell signaling|nervous system development|axon guidance|adult walking behavior|axon choice point recognition|T cell costimulation|viral entry into host cell|ephrin receptor binding|ephrin receptor signaling pathway|negative regulation of axonogenesis|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|integral component of presynaptic membrane|integral component of postsynaptic density membrane|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission" hsa04360 Axon guidance EFR3A 3317.038655 3714.738844 2919.338466 0.785879866 -0.347619303 0.274596573 1 33.89881399 27.7879556 23167 EFR3 homolog A "GO:0005829,GO:0005886,GO:0046854,GO:0072659" cytosol|plasma membrane|phosphatidylinositol phosphorylation|protein localization to plasma membrane EFR3B 12.01616809 13.19442759 10.83790858 0.821400437 -0.283842381 0.889026967 1 0.086898727 0.074453355 22979 EFR3 homolog B "GO:0005515,GO:0005829,GO:0005886,GO:0015629,GO:0046854,GO:0072659" protein binding|cytosol|plasma membrane|actin cytoskeleton|phosphatidylinositol phosphorylation|protein localization to plasma membrane EFTUD2 4254.853265 4545.987782 3963.718748 0.871915838 -0.197739209 0.535740192 1 48.77928896 44.36351633 9343 elongation factor Tu GTP binding domain containing 2 "GO:0000398,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005829,GO:0015030,GO:0016020,GO:0016607,GO:0030623,GO:0035690,GO:0042220,GO:0043231,GO:0046540,GO:0071005,GO:0071007,GO:0071013,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytosol|Cajal body|membrane|nuclear speck|U5 snRNA binding|cellular response to drug|response to cocaine|intracellular membrane-bounded organelle|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|ribonucleoprotein complex" hsa03040 Spliceosome EGF 9.04552906 12.17947162 5.911586499 0.485372985 -1.042834281 0.499104294 1 0.101605546 0.051440946 1950 epidermal growth factor "GO:0000165,GO:0000186,GO:0000187,GO:0001525,GO:0001938,GO:0002092,GO:0002576,GO:0005085,GO:0005154,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005765,GO:0005886,GO:0007165,GO:0007171,GO:0007173,GO:0008083,GO:0008284,GO:0010595,GO:0010628,GO:0010800,GO:0014068,GO:0016021,GO:0018108,GO:0021940,GO:0030297,GO:0030335,GO:0030665,GO:0031093,GO:0038029,GO:0038128,GO:0042059,GO:0042327,GO:0043388,GO:0043406,GO:0043410,GO:0045740,GO:0045741,GO:0045746,GO:0045840,GO:0045893,GO:0046425,GO:0048754,GO:0051048,GO:0051897,GO:0060749,GO:0061024,GO:0070062,GO:0070371,GO:0090263,GO:0090279,GO:0090370,GO:1900127,GO:1901185,GO:1902966,GO:1905278,GO:2000008,GO:2000060,GO:2000145" "MAPK cascade|activation of MAPKK activity|activation of MAPK activity|angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of receptor internalization|platelet degranulation|guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|calcium ion binding|protein binding|extracellular region|extracellular space|lysosomal membrane|plasma membrane|signal transduction|activation of transmembrane receptor protein tyrosine kinase activity|epidermal growth factor receptor signaling pathway|growth factor activity|positive regulation of cell population proliferation|positive regulation of endothelial cell migration|positive regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|peptidyl-tyrosine phosphorylation|positive regulation of cerebellar granule cell precursor proliferation|transmembrane receptor protein tyrosine kinase activator activity|positive regulation of cell migration|clathrin-coated vesicle membrane|platelet alpha granule lumen|epidermal growth factor receptor signaling pathway via MAPK cascade|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphorylation|positive regulation of DNA binding|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of DNA replication|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of Notch signaling pathway|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|regulation of receptor signaling pathway via JAK-STAT|branching morphogenesis of an epithelial tube|negative regulation of secretion|positive regulation of protein kinase B signaling|mammary gland alveolus development|membrane organization|extracellular exosome|ERK1 and ERK2 cascade|positive regulation of canonical Wnt signaling pathway|regulation of calcium ion import|negative regulation of cholesterol efflux|positive regulation of hyaluronan biosynthetic process|negative regulation of ERBB signaling pathway|positive regulation of protein localization to early endosome|positive regulation of epithelial tube formation|regulation of protein localization to cell surface|positive regulation of ubiquitin-dependent protein catabolic process|regulation of cell motility" "hsa01521,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04068,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05160,hsa05165,hsa05200,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05223,hsa05224,hsa05226,hsa05231,hsa05235" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|Hepatitis C|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Non-small cell lung cancer|Breast cancer|Gastric cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer EGFL7 383.5766516 425.2665507 341.8867525 0.803935207 -0.314848862 0.474580349 1 7.933057291 6.652387958 51162 EGF like domain multiple 7 "GO:0001525,GO:0001568,GO:0001570,GO:0001938,GO:0005102,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0007155,GO:0009986,GO:0045746,GO:0048856,GO:0062023" angiogenesis|blood vessel development|vasculogenesis|positive regulation of endothelial cell proliferation|signaling receptor binding|calcium ion binding|protein binding|extracellular region|extracellular space|cell adhesion|cell surface|negative regulation of Notch signaling pathway|anatomical structure development|collagen-containing extracellular matrix EGFL8 102.6995885 83.22638941 122.1727877 1.467957321 0.553810025 0.412526488 1 3.247398319 4.97238698 80864 EGF like domain multiple 8 "GO:0001701,GO:0005102,GO:0005509,GO:0005515,GO:0005576,GO:0009986,GO:0048856" in utero embryonic development|signaling receptor binding|calcium ion binding|protein binding|extracellular region|cell surface|anatomical structure development EGFLAM 151.897983 146.1536594 157.6423066 1.078606634 0.109168812 0.863367717 1 1.415869788 1.592950687 133584 "EGF like, fibronectin type III and laminin G domains" "GO:0005509,GO:0005539,GO:0005604,GO:0005614,GO:0009887,GO:0009888,GO:0010811,GO:0019800,GO:0030198,GO:0042995,GO:0043083,GO:0048786" calcium ion binding|glycosaminoglycan binding|basement membrane|interstitial matrix|animal organ morphogenesis|tissue development|positive regulation of cell-substrate adhesion|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix organization|cell projection|synaptic cleft|presynaptic active zone EGFR 12663.52318 13297.9531 12029.09326 0.90458232 -0.144676296 0.67410468 1 61.96470807 58.46667993 1956 epidermal growth factor receptor "GO:0000139,GO:0000165,GO:0000186,GO:0001503,GO:0001618,GO:0001934,GO:0001942,GO:0003682,GO:0003690,GO:0004709,GO:0004713,GO:0004714,GO:0004888,GO:0005006,GO:0005178,GO:0005515,GO:0005516,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005768,GO:0005789,GO:0005886,GO:0005887,GO:0005925,GO:0006357,GO:0006412,GO:0006970,GO:0007165,GO:0007166,GO:0007169,GO:0007173,GO:0007202,GO:0007275,GO:0007494,GO:0007611,GO:0007623,GO:0008284,GO:0009925,GO:0009986,GO:0010008,GO:0010750,GO:0010960,GO:0014066,GO:0016020,GO:0016101,GO:0016323,GO:0016324,GO:0018108,GO:0019899,GO:0019900,GO:0019901,GO:0019903,GO:0030054,GO:0030139,GO:0030154,GO:0030235,GO:0030307,GO:0030324,GO:0030335,GO:0030665,GO:0031625,GO:0031901,GO:0031965,GO:0032930,GO:0032991,GO:0033138,GO:0033590,GO:0033594,GO:0033674,GO:0034614,GO:0035690,GO:0038083,GO:0038128,GO:0042059,GO:0042060,GO:0042177,GO:0042327,GO:0042698,GO:0042743,GO:0042802,GO:0043006,GO:0043066,GO:0043235,GO:0043406,GO:0043586,GO:0045121,GO:0045202,GO:0045296,GO:0045737,GO:0045739,GO:0045740,GO:0045746,GO:0045780,GO:0045893,GO:0045907,GO:0045930,GO:0045944,GO:0046328,GO:0046718,GO:0046777,GO:0048143,GO:0048408,GO:0048471,GO:0048661,GO:0048812,GO:0050679,GO:0050729,GO:0050730,GO:0050999,GO:0051015,GO:0051117,GO:0051205,GO:0051592,GO:0051897,GO:0051968,GO:0061024,GO:0070141,GO:0070372,GO:0070374,GO:0070435,GO:0071260,GO:0071276,GO:0071364,GO:0071392,GO:0071549,GO:0090263,GO:0097421,GO:0097489,GO:0098609,GO:1900020,GO:1900087,GO:1901185,GO:1901224,GO:1902722,GO:1903078,GO:1903800,GO:1905208,GO:2000145" "Golgi membrane|MAPK cascade|activation of MAPKK activity|ossification|virus receptor activity|positive regulation of protein phosphorylation|hair follicle development|chromatin binding|double-stranded DNA binding|MAP kinase kinase kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane signaling receptor activity|epidermal growth factor-activated receptor activity|integrin binding|protein binding|calmodulin binding|ATP binding|extracellular space|nucleus|cytoplasm|endosome|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|focal adhesion|regulation of transcription by RNA polymerase II|translation|response to osmotic stress|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|multicellular organism development|midgut development|learning or memory|circadian rhythm|positive regulation of cell population proliferation|basal plasma membrane|cell surface|endosome membrane|positive regulation of nitric oxide mediated signal transduction|magnesium ion homeostasis|regulation of phosphatidylinositol 3-kinase signaling|membrane|diterpenoid metabolic process|basolateral plasma membrane|apical plasma membrane|peptidyl-tyrosine phosphorylation|enzyme binding|kinase binding|protein kinase binding|protein phosphatase binding|cell junction|endocytic vesicle|cell differentiation|nitric-oxide synthase regulator activity|positive regulation of cell growth|lung development|positive regulation of cell migration|clathrin-coated vesicle membrane|ubiquitin protein ligase binding|early endosome membrane|nuclear membrane|positive regulation of superoxide anion generation|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|response to cobalamin|response to hydroxyisoflavone|positive regulation of kinase activity|cellular response to reactive oxygen species|cellular response to drug|peptidyl-tyrosine autophosphorylation|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|wound healing|negative regulation of protein catabolic process|positive regulation of phosphorylation|ovulation cycle|hydrogen peroxide metabolic process|identical protein binding|activation of phospholipase A2 activity by calcium-mediated signaling|negative regulation of apoptotic process|receptor complex|positive regulation of MAP kinase activity|tongue development|membrane raft|synapse|cadherin binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of DNA repair|positive regulation of DNA replication|negative regulation of Notch signaling pathway|positive regulation of bone resorption|positive regulation of transcription, DNA-templated|positive regulation of vasoconstriction|negative regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|regulation of JNK cascade|viral entry into host cell|protein autophosphorylation|astrocyte activation|epidermal growth factor binding|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|neuron projection morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of inflammatory response|regulation of peptidyl-tyrosine phosphorylation|regulation of nitric-oxide synthase activity|actin filament binding|ATPase binding|protein insertion into membrane|response to calcium ion|positive regulation of protein kinase B signaling|positive regulation of synaptic transmission, glutamatergic|membrane organization|response to UV-A|regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|Shc-EGFR complex|cellular response to mechanical stimulus|cellular response to cadmium ion|cellular response to epidermal growth factor stimulus|cellular response to estradiol stimulus|cellular response to dexamethasone stimulus|positive regulation of canonical Wnt signaling pathway|liver regeneration|multivesicular body, internal vesicle lumen|cell-cell adhesion|positive regulation of protein kinase C activity|positive regulation of G1/S transition of mitotic cell cycle|negative regulation of ERBB signaling pathway|positive regulation of NIK/NF-kappaB signaling|positive regulation of prolactin secretion|positive regulation of protein localization to plasma membrane|positive regulation of production of miRNAs involved in gene silencing by miRNA|negative regulation of cardiocyte differentiation|regulation of cell motility" "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04068,hsa04072,hsa04144,hsa04151,hsa04510,hsa04520,hsa04540,hsa04630,hsa04810,hsa04912,hsa04915,hsa04921,hsa04926,hsa04928,hsa04934,hsa05120,hsa05131,hsa05160,hsa05163,hsa05165,hsa05171,hsa05200,hsa05205,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Focal adhesion|Adherens junction|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|GnRH signaling pathway|Estrogen signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Hepatitis C|Human cytomegalovirus infection|Human papillomavirus infection|Coronavirus disease - COVID-19|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" EGLN1 1683.257953 2285.680841 1080.835065 0.47287226 -1.080477583 0.001070685 0.094234211 26.41754249 13.03023302 54583 egl-9 family hypoxia inducible factor 1 "GO:0001666,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008198,GO:0016706,GO:0018401,GO:0019899,GO:0031418,GO:0031543,GO:0031545,GO:0032364,GO:0043433,GO:0045765,GO:0051344,GO:0055114,GO:0061418,GO:0071456,GO:0071731" response to hypoxia|protein binding|nucleus|cytoplasm|cytosol|ferrous iron binding|2-oxoglutarate-dependent dioxygenase activity|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|enzyme binding|L-ascorbic acid binding|peptidyl-proline dioxygenase activity|peptidyl-proline 4-dioxygenase activity|oxygen homeostasis|negative regulation of DNA-binding transcription factor activity|regulation of angiogenesis|negative regulation of cyclic-nucleotide phosphodiesterase activity|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|response to nitric oxide "hsa04066,hsa05200,hsa05211" HIF-1 signaling pathway|Pathways in cancer|Renal cell carcinoma EGLN2 1216.412104 1118.481477 1314.342732 1.175113543 0.232800161 0.495777466 1 25.55125893 31.3190128 112398 egl-9 family hypoxia inducible factor 2 "GO:0001558,GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008198,GO:0016706,GO:0018401,GO:0019826,GO:0030520,GO:0031418,GO:0031543,GO:0031545,GO:0043523,GO:0045454,GO:0045732,GO:0055114,GO:0061418,GO:0071456" regulation of cell growth|response to hypoxia|protein binding|nucleus|nucleoplasm|cytoplasm|ferrous iron binding|2-oxoglutarate-dependent dioxygenase activity|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|oxygen sensor activity|intracellular estrogen receptor signaling pathway|L-ascorbic acid binding|peptidyl-proline dioxygenase activity|peptidyl-proline 4-dioxygenase activity|regulation of neuron apoptotic process|cell redox homeostasis|positive regulation of protein catabolic process|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia "hsa04066,hsa05200,hsa05211" HIF-1 signaling pathway|Pathways in cancer|Renal cell carcinoma other EGLN3 81.9293637 145.1387035 18.72002391 0.128980234 -2.954778105 0.000176622 0.02519926 2.716468334 0.365463271 112399 egl-9 family hypoxia inducible factor 3 "GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0006974,GO:0008198,GO:0016706,GO:0018126,GO:0018401,GO:0031418,GO:0031543,GO:0031545,GO:0042127,GO:0043523,GO:0055114,GO:0061418,GO:0071456" response to hypoxia|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|ferrous iron binding|2-oxoglutarate-dependent dioxygenase activity|protein hydroxylation|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|L-ascorbic acid binding|peptidyl-proline dioxygenase activity|peptidyl-proline 4-dioxygenase activity|regulation of cell population proliferation|regulation of neuron apoptotic process|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia "hsa04066,hsa05200,hsa05211" HIF-1 signaling pathway|Pathways in cancer|Renal cell carcinoma EGR1 267.6638304 179.6472064 355.6804544 1.979883025 0.985415196 0.045516019 0.96408227 2.900381653 5.98977641 1958 early growth response 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0002931,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0008270,GO:0009749,GO:0010385,GO:0010628,GO:0030217,GO:0030509,GO:0032722,GO:0032731,GO:0032868,GO:0032922,GO:0033233,GO:0035035,GO:0035914,GO:0042981,GO:0043565,GO:0044729,GO:0044849,GO:0045475,GO:0045893,GO:0045944,GO:0046886,GO:0060086,GO:0060337,GO:0061418,GO:0070498,GO:0071480,GO:0071504,GO:0071506,GO:0072110,GO:0072303,GO:0090090,GO:0098759,GO:1901216,GO:1902895,GO:1902949,GO:1990837,GO:1990841,GO:2000182" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|response to ischemia|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|zinc ion binding|response to glucose|double-stranded methylated DNA binding|positive regulation of gene expression|T cell differentiation|BMP signaling pathway|positive regulation of chemokine production|positive regulation of interleukin-1 beta production|response to insulin|circadian regulation of gene expression|regulation of protein sumoylation|histone acetyltransferase binding|skeletal muscle cell differentiation|regulation of apoptotic process|sequence-specific DNA binding|hemi-methylated DNA-binding|estrous cycle|locomotor rhythm|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of hormone biosynthetic process|circadian temperature homeostasis|type I interferon signaling pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|cellular response to gamma radiation|cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|positive regulation of glomerular metanephric mesangial cell proliferation|negative regulation of canonical Wnt signaling pathway|cellular response to interleukin-8|positive regulation of neuron death|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of tau-protein kinase activity|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding|regulation of progesterone biosynthetic process" "hsa04371,hsa04912,hsa04928,hsa04933,hsa05020,hsa05166" "Apelin signaling pathway|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action|AGE-RAGE signaling pathway in diabetic complications|Prion disease|Human T-cell leukemia virus 1 infection" zf-C2H2 EGR3 7.448866228 4.059823873 10.83790858 2.669551419 1.416597337 0.391522599 1 0.04452485 0.123981442 1960 early growth response 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001938,GO:0002042,GO:0003700,GO:0005634,GO:0006357,GO:0007274,GO:0007422,GO:0007517,GO:0007623,GO:0033089,GO:0035767,GO:0035924,GO:0043066,GO:0044344,GO:0045202,GO:0045586,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|neuromuscular synaptic transmission|peripheral nervous system development|muscle organ development|circadian rhythm|positive regulation of T cell differentiation in thymus|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|negative regulation of apoptotic process|cellular response to fibroblast growth factor stimulus|synapse|regulation of gamma-delta T cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" "hsa04625,hsa05161,hsa05203" C-type lectin receptor signaling pathway|Hepatitis B|Viral carcinogenesis zf-C2H2 EGR4 11.98647653 11.16451565 12.80843742 1.147245238 0.198173818 0.947374756 1 0.254704203 0.304795328 1961 early growth response 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0008284,GO:0043565,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" EHBP1 1449.250227 1274.784696 1623.715758 1.273717643 0.349045497 0.294667794 1 8.55030429 11.35979947 23301 EH domain binding protein 1 "GO:0005654,GO:0005768,GO:0005815,GO:0005829,GO:0005886,GO:0006897,GO:0015031,GO:0030036,GO:0031941" nucleoplasm|endosome|microtubule organizing center|cytosol|plasma membrane|endocytosis|protein transport|actin cytoskeleton organization|filamentous actin EHBP1L1 2913.708465 2780.979353 3046.437576 1.095454942 0.131530145 0.679868414 1 26.0586112 29.77568181 254102 EH domain binding protein 1 like 1 "GO:0003674,GO:0005768,GO:0005815,GO:0008150,GO:0016020,GO:0030036,GO:0031941" molecular_function|endosome|microtubule organizing center|biological_process|membrane|actin cytoskeleton organization|filamentous actin EHD1 2780.933571 3369.653815 2192.213327 0.650575236 -0.620212187 0.051997939 1 35.1371378 23.84403989 10938 EH domain containing 1 "GO:0005509,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005769,GO:0005811,GO:0005886,GO:0006886,GO:0006897,GO:0007596,GO:0010008,GO:0010886,GO:0016020,GO:0016197,GO:0020018,GO:0030139,GO:0031095,GO:0031175,GO:0031267,GO:0031901,GO:0032456,GO:0034383,GO:0042632,GO:0042802,GO:0043231,GO:0045296,GO:0048471,GO:0051260,GO:0055038,GO:0060271,GO:0061512,GO:0070062,GO:0072659,GO:1901741,GO:1990090,GO:2001137" calcium ion binding|protein binding|ATP binding|GTP binding|cytoplasm|early endosome|lipid droplet|plasma membrane|intracellular protein transport|endocytosis|blood coagulation|endosome membrane|positive regulation of cholesterol storage|membrane|endosomal transport|ciliary pocket membrane|endocytic vesicle|platelet dense tubular network membrane|neuron projection development|small GTPase binding|early endosome membrane|endocytic recycling|low-density lipoprotein particle clearance|cholesterol homeostasis|identical protein binding|intracellular membrane-bounded organelle|cadherin binding|perinuclear region of cytoplasm|protein homooligomerization|recycling endosome membrane|cilium assembly|protein localization to cilium|extracellular exosome|protein localization to plasma membrane|positive regulation of myoblast fusion|cellular response to nerve growth factor stimulus|positive regulation of endocytic recycling hsa04144 Endocytosis EHD2 3198.955875 2983.970547 3413.941203 1.144093465 0.194204916 0.541686484 1 43.10541397 51.44098253 30846 EH domain containing 2 "GO:0003676,GO:0005509,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0005901,GO:0006897,GO:0007596,GO:0010008,GO:0015630,GO:0016197,GO:0016787,GO:0019898,GO:0019904,GO:0030139,GO:0030866,GO:0032456,GO:0042802,GO:0043231,GO:0045171,GO:0048471,GO:0055038,GO:0060271,GO:0070062,GO:0072659,GO:0097320,GO:1901741,GO:2001137" nucleic acid binding|calcium ion binding|protein binding|ATP binding|GTP binding|nucleus|cytoplasm|early endosome|cytosol|plasma membrane|caveola|endocytosis|blood coagulation|endosome membrane|microtubule cytoskeleton|endosomal transport|hydrolase activity|extrinsic component of membrane|protein domain specific binding|endocytic vesicle|cortical actin cytoskeleton organization|endocytic recycling|identical protein binding|intracellular membrane-bounded organelle|intercellular bridge|perinuclear region of cytoplasm|recycling endosome membrane|cilium assembly|extracellular exosome|protein localization to plasma membrane|plasma membrane tubulation|positive regulation of myoblast fusion|positive regulation of endocytic recycling hsa04144 Endocytosis EHD3 347.4484753 447.5955821 247.3013686 0.552510745 -0.855925573 0.05895564 1 4.627298879 2.666761705 30845 EH domain containing 3 "GO:0001881,GO:0003676,GO:0005509,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0005925,GO:0006897,GO:0007596,GO:0010008,GO:0015031,GO:0016197,GO:0020018,GO:0030139,GO:0032456,GO:0034498,GO:0043231,GO:0048471,GO:0051260,GO:0055038,GO:0055117,GO:0060271,GO:0072659,GO:0086036,GO:0090160,GO:1901387,GO:1903358,GO:1903779" receptor recycling|nucleic acid binding|calcium ion binding|protein binding|ATP binding|GTP binding|nucleus|cytoplasm|early endosome|cytosol|plasma membrane|focal adhesion|endocytosis|blood coagulation|endosome membrane|protein transport|endosomal transport|ciliary pocket membrane|endocytic vesicle|endocytic recycling|early endosome to Golgi transport|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|protein homooligomerization|recycling endosome membrane|regulation of cardiac muscle contraction|cilium assembly|protein localization to plasma membrane|regulation of cardiac muscle cell membrane potential|Golgi to lysosome transport|positive regulation of voltage-gated calcium channel activity|regulation of Golgi organization|regulation of cardiac conduction hsa04144 Endocytosis EHD4 1487.124762 1439.207563 1535.041961 1.066588309 0.09300342 0.780749698 1 11.38740601 12.6688605 30844 EH domain containing 4 "GO:0003676,GO:0005509,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005886,GO:0006897,GO:0006907,GO:0016020,GO:0016197,GO:0030100,GO:0030139,GO:0031901,GO:0032456,GO:0043231,GO:0045296,GO:0048471,GO:0050731,GO:0051260,GO:0055038,GO:0060271,GO:0070062,GO:0071363,GO:0072659" nucleic acid binding|calcium ion binding|protein binding|ATP binding|GTP binding|nucleus|cytoplasm|early endosome|endoplasmic reticulum|plasma membrane|endocytosis|pinocytosis|membrane|endosomal transport|regulation of endocytosis|endocytic vesicle|early endosome membrane|endocytic recycling|intracellular membrane-bounded organelle|cadherin binding|perinuclear region of cytoplasm|positive regulation of peptidyl-tyrosine phosphorylation|protein homooligomerization|recycling endosome membrane|cilium assembly|extracellular exosome|cellular response to growth factor stimulus|protein localization to plasma membrane hsa04144 Endocytosis EHF 205.6649172 386.698224 24.63161041 0.063697242 -3.972625279 1.56E-10 1.76E-07 2.715222633 0.180402273 26298 ETS homologous factor "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005794,GO:0006357,GO:0006366,GO:0007275,GO:0030154,GO:0030855,GO:0045893,GO:0045944,GO:0050673" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|Golgi apparatus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|multicellular organism development|cell differentiation|epithelial cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|epithelial cell proliferation" ETS EHHADH 368.8085718 291.2923629 446.3247807 1.532222734 0.615626032 0.165908366 1 3.730197361 5.961693466 1962 enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase "GO:0003857,GO:0004165,GO:0004300,GO:0005515,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0016508,GO:0016509,GO:0016863,GO:0019899,GO:0033540" "3-hydroxyacyl-CoA dehydrogenase activity|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity|protein binding|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|long-chain-enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|intramolecular oxidoreductase activity, transposing C=C bonds|enzyme binding|fatty acid beta-oxidation using acyl-CoA oxidase" "hsa00071,hsa00280,hsa00310,hsa00380,hsa00410,hsa00640,hsa00650,hsa03320,hsa04146" "Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism|PPAR signaling pathway|Peroxisome" EHMT1 1570.252674 1531.568556 1608.936792 1.050515686 0.071097704 0.830837811 1 7.538245318 8.26016529 79813 euchromatic histone lysine methyltransferase 1 "GO:0000122,GO:0001226,GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006306,GO:0006325,GO:0008168,GO:0008270,GO:0016279,GO:0016571,GO:0016604,GO:0018024,GO:0018026,GO:0018027,GO:0045892,GO:0045995,GO:0046974,GO:0046976,GO:0051567,GO:0060992,GO:0070317,GO:0070734,GO:0070742,GO:0120162,GO:1901796" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|p53 binding|protein binding|nucleus|nucleoplasm|chromosome|DNA methylation|chromatin organization|methyltransferase activity|zinc ion binding|protein-lysine N-methyltransferase activity|histone methylation|nuclear body|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|negative regulation of transcription, DNA-templated|regulation of embryonic development|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K27 specific)|histone H3-K9 methylation|response to fungicide|negative regulation of G0 to G1 transition|histone H3-K27 methylation|C2H2 zinc finger domain binding|positive regulation of cold-induced thermogenesis|regulation of signal transduction by p53 class mediator" "hsa00310,hsa04211" Lysine degradation|Longevity regulating pathway EHMT2 1324.734283 1451.387035 1198.081531 0.825473497 -0.276706199 0.411965652 1 17.12267252 14.74316121 10919 euchromatic histone lysine methyltransferase 2 "GO:0000122,GO:0000785,GO:0001226,GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0006275,GO:0006306,GO:0008270,GO:0009267,GO:0016279,GO:0016571,GO:0016607,GO:0018024,GO:0018027,GO:0034968,GO:0046974,GO:0046976,GO:0051567,GO:0070317,GO:0070734,GO:0070742,GO:1901796,GO:1990841" negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription corepressor binding|p53 binding|protein binding|nucleus|nucleoplasm|regulation of DNA replication|DNA methylation|zinc ion binding|cellular response to starvation|protein-lysine N-methyltransferase activity|histone methylation|nuclear speck|histone-lysine N-methyltransferase activity|peptidyl-lysine dimethylation|histone lysine methylation|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K27 specific)|histone H3-K9 methylation|negative regulation of G0 to G1 transition|histone H3-K27 methylation|C2H2 zinc finger domain binding|regulation of signal transduction by p53 class mediator|promoter-specific chromatin binding "hsa00310,hsa04211" Lysine degradation|Longevity regulating pathway other EI24 3221.480377 3378.788419 3064.172335 0.906884941 -0.141008571 0.657901585 1 67.39807552 63.75520052 9538 EI24 autophagy associated transmembrane protein "GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006915,GO:0016020,GO:0016021,GO:0016236,GO:0030308,GO:0031965,GO:0061676" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|apoptotic process|membrane|integral component of membrane|macroautophagy|negative regulation of cell growth|nuclear membrane|importin-alpha family protein binding hsa04115 p53 signaling pathway EID1 2609.703174 2676.438889 2542.967459 0.950130963 -0.073801711 0.817807494 1 66.44715088 65.85303041 23741 EP300 interacting inhibitor of differentiation 1 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0007049,GO:0030154,GO:0035034,GO:0035035,GO:0035065,GO:0036464,GO:0045595,GO:0045892" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cell cycle|cell differentiation|histone acetyltransferase regulator activity|histone acetyltransferase binding|regulation of histone acetylation|cytoplasmic ribonucleoprotein granule|regulation of cell differentiation|negative regulation of transcription, DNA-templated" EID2 270.3887722 264.9035077 275.8740366 1.041413302 0.058542739 0.912228399 1 9.220912814 10.01643013 163126 EP300 interacting inhibitor of differentiation 2 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0007181,GO:0007183,GO:0007517,GO:0017015,GO:0030154,GO:0030512,GO:0042127,GO:0045892,GO:0046332" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transforming growth factor beta receptor complex assembly|SMAD protein complex assembly|muscle organ development|regulation of transforming growth factor beta receptor signaling pathway|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell population proliferation|negative regulation of transcription, DNA-templated|SMAD binding" EID2B 54.46889105 52.77771036 56.16007174 1.064086929 0.089616015 0.936726712 1 1.432478479 1.589941496 126272 EP300 interacting inhibitor of differentiation 2B "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0007517,GO:0030154,GO:0042802,GO:0045662,GO:0045892" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|muscle organ development|cell differentiation|identical protein binding|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-templated" EID3 11.5680732 16.23929549 6.896850916 0.424701362 -1.235479359 0.365657923 1 0.560642828 0.248362404 493861 EP300 interacting inhibitor of differentiation 3 "GO:0000781,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006281,GO:0006310,GO:0030915" "chromosome, telomeric region|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA repair|DNA recombination|Smc5-Smc6 complex" EIF1 10248.18407 8989.465012 11506.90312 1.280043151 0.356192445 0.29112544 1 194.7325449 260.0034313 10209 eukaryotic translation initiation factor 1 "GO:0003723,GO:0003743,GO:0005515,GO:0005634,GO:0005737,GO:0006413,GO:0006446,GO:0008135,GO:0016282,GO:0043024" "RNA binding|translation initiation factor activity|protein binding|nucleus|cytoplasm|translational initiation|regulation of translational initiation|translation factor activity, RNA binding|eukaryotic 43S preinitiation complex|ribosomal small subunit binding" hsa03013 RNA transport EIF1AD 636.0228235 675.9606749 596.084972 0.881833802 -0.181421316 0.640133322 1 11.1988955 10.30096387 84285 eukaryotic translation initiation factor 1A domain containing "GO:0003743,GO:0005515,GO:0005654,GO:0006413,GO:0043231,GO:0045111" translation initiation factor activity|protein binding|nucleoplasm|translational initiation|intracellular membrane-bounded organelle|intermediate filament cytoskeleton EIF1AX 1636.103324 1688.886731 1583.319917 0.937493254 -0.093119786 0.77790477 1 19.37837674 18.94966234 1964 eukaryotic translation initiation factor 1A X-linked "GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0006413,GO:0008135" "RNA binding|translation initiation factor activity|protein binding|cytosol|translational initiation|translation factor activity, RNA binding" hsa03013 RNA transport EIF1B 818.6233476 698.2897062 938.956989 1.344652485 0.427233368 0.242867752 1 35.8317226 50.25666617 10289 eukaryotic translation initiation factor 1B "GO:0003723,GO:0003743,GO:0005515,GO:0005575,GO:0006413,GO:0006446,GO:0016282,GO:0043024" RNA binding|translation initiation factor activity|protein binding|cellular_component|translational initiation|regulation of translational initiation|eukaryotic 43S preinitiation complex|ribosomal small subunit binding hsa03013 RNA transport EIF2A 1553.971563 1462.55155 1645.391576 1.125014414 0.169943486 0.607436918 1 24.60082247 28.86846177 83939 eukaryotic translation initiation factor 2A "GO:0000049,GO:0003729,GO:0003743,GO:0005515,GO:0005615,GO:0005737,GO:0005850,GO:0006413,GO:0006417,GO:0006468,GO:0009967,GO:0022627,GO:0032933,GO:0042255,GO:0043022,GO:0045296,GO:0072562,GO:1990928" tRNA binding|mRNA binding|translation initiation factor activity|protein binding|extracellular space|cytoplasm|eukaryotic translation initiation factor 2 complex|translational initiation|regulation of translation|protein phosphorylation|positive regulation of signal transduction|cytosolic small ribosomal subunit|SREBP signaling pathway|ribosome assembly|ribosome binding|cadherin binding|blood microparticle|response to amino acid starvation EIF2AK1 4374.986984 4103.46698 4646.506988 1.132336878 0.179303233 0.574785344 1 45.3471801 53.56016017 27102 eukaryotic translation initiation factor 2 alpha kinase 1 "GO:0002526,GO:0004672,GO:0004694,GO:0005515,GO:0005524,GO:0005737,GO:0006909,GO:0008285,GO:0010998,GO:0010999,GO:0020037,GO:0030225,GO:0042803,GO:0045993,GO:0046501,GO:0046777,GO:0046986,GO:0055072,GO:0106310,GO:0106311,GO:0140467,GO:0140468,GO:1990641" acute inflammatory response|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|ATP binding|cytoplasm|phagocytosis|negative regulation of cell population proliferation|regulation of translational initiation by eIF2 alpha phosphorylation|regulation of eIF2 alpha phosphorylation by heme|heme binding|macrophage differentiation|protein homodimerization activity|negative regulation of translational initiation by iron|protoporphyrinogen IX metabolic process|protein autophosphorylation|negative regulation of hemoglobin biosynthetic process|iron ion homeostasis|protein serine kinase activity|protein threonine kinase activity|integrated stress response signaling|HRI-mediated signaling|response to iron ion starvation "hsa04141,hsa05160,hsa05162,hsa05168" Protein processing in endoplasmic reticulum|Hepatitis C|Measles|Herpes simplex virus 1 infection EIF2AK2 2158.085378 2045.136276 2271.03448 1.110456309 0.151152631 0.638051031 1 10.38697729 12.03113466 5610 eukaryotic translation initiation factor 2 alpha kinase 2 "GO:0000186,GO:0001819,GO:0003723,GO:0003725,GO:0004672,GO:0004674,GO:0004694,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005840,GO:0006468,GO:0008285,GO:0009615,GO:0010998,GO:0016020,GO:0017148,GO:0018108,GO:0019888,GO:0030683,GO:0032722,GO:0032874,GO:0033689,GO:0034198,GO:0035455,GO:0042802,GO:0043666,GO:0045071,GO:0045087,GO:0046777,GO:0048471,GO:0051092,GO:0051607,GO:0106310,GO:0106311,GO:1900225,GO:1901224,GO:1901532,GO:1902033,GO:1902036" activation of MAPKK activity|positive regulation of cytokine production|RNA binding|double-stranded RNA binding|protein kinase activity|protein serine/threonine kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|ribosome|protein phosphorylation|negative regulation of cell population proliferation|response to virus|regulation of translational initiation by eIF2 alpha phosphorylation|membrane|negative regulation of translation|peptidyl-tyrosine phosphorylation|protein phosphatase regulator activity|mitigation of host immune response by virus|positive regulation of chemokine production|positive regulation of stress-activated MAPK cascade|negative regulation of osteoblast proliferation|cellular response to amino acid starvation|response to interferon-alpha|identical protein binding|regulation of phosphoprotein phosphatase activity|negative regulation of viral genome replication|innate immune response|protein autophosphorylation|perinuclear region of cytoplasm|positive regulation of NF-kappaB transcription factor activity|defense response to virus|protein serine kinase activity|protein threonine kinase activity|regulation of NLRP3 inflammasome complex assembly|positive regulation of NIK/NF-kappaB signaling|regulation of hematopoietic progenitor cell differentiation|regulation of hematopoietic stem cell proliferation|regulation of hematopoietic stem cell differentiation "hsa04141,hsa04217,hsa05010,hsa05160,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05203" Protein processing in endoplasmic reticulum|Necroptosis|Alzheimer disease|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Viral carcinogenesis EIF2AK3 360.3608331 454.7002738 266.0213925 0.585047795 -0.773373606 0.084193702 1 4.874886703 2.974896105 9451 eukaryotic translation initiation factor 2 alpha kinase 3 "GO:0001501,GO:0001503,GO:0001525,GO:0002063,GO:0004672,GO:0004674,GO:0004694,GO:0005515,GO:0005524,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006468,GO:0006919,GO:0006983,GO:0007029,GO:0010575,GO:0010628,GO:0010998,GO:0016020,GO:0017148,GO:0018105,GO:0019722,GO:0019899,GO:0019903,GO:0030176,GO:0030282,GO:0030968,GO:0031018,GO:0031642,GO:0032057,GO:0034198,GO:0034976,GO:0036492,GO:0036499,GO:0042149,GO:0042802,GO:0045943,GO:0046777,GO:0048009,GO:0048471,GO:0051879,GO:0060734,GO:0070417,GO:0106310,GO:0106311,GO:1900182,GO:1902235,GO:1990737" skeletal system development|ossification|angiogenesis|chondrocyte development|protein kinase activity|protein serine/threonine kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|ATP binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|ER overload response|endoplasmic reticulum organization|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|regulation of translational initiation by eIF2 alpha phosphorylation|membrane|negative regulation of translation|peptidyl-serine phosphorylation|calcium-mediated signaling|enzyme binding|protein phosphatase binding|integral component of endoplasmic reticulum membrane|bone mineralization|endoplasmic reticulum unfolded protein response|endocrine pancreas development|negative regulation of myelination|negative regulation of translational initiation in response to stress|cellular response to amino acid starvation|response to endoplasmic reticulum stress|eiF2alpha phosphorylation in response to endoplasmic reticulum stress|PERK-mediated unfolded protein response|cellular response to glucose starvation|identical protein binding|positive regulation of transcription by RNA polymerase I|protein autophosphorylation|insulin-like growth factor receptor signaling pathway|perinuclear region of cytoplasm|Hsp90 protein binding|regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|cellular response to cold|protein serine kinase activity|protein threonine kinase activity|positive regulation of protein localization to nucleus|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|response to manganese-induced endoplasmic reticulum stress "hsa04137,hsa04140,hsa04141,hsa04210,hsa04932,hsa05010,hsa05012,hsa05014,hsa05020,hsa05022,hsa05160,hsa05162,hsa05168" Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Hepatitis C|Measles|Herpes simplex virus 1 infection EIF2AK4 2236.612338 1991.34361 2481.881065 1.246334913 0.317691799 0.321227874 1 18.21136309 23.67517206 440275 eukaryotic translation initiation factor 2 alpha kinase 4 "GO:0000049,GO:0000077,GO:0002230,GO:0002250,GO:0002286,GO:0002821,GO:0004672,GO:0004674,GO:0004694,GO:0005524,GO:0005829,GO:0005844,GO:0006446,GO:0006468,GO:0007050,GO:0007612,GO:0007616,GO:0010998,GO:0019081,GO:0022626,GO:0032057,GO:0032792,GO:0034198,GO:0034644,GO:0036492,GO:0039520,GO:0044828,GO:0045665,GO:0045947,GO:0046777,GO:0051607,GO:0060259,GO:0070417,GO:0071264,GO:0106310,GO:0106311,GO:0140469,GO:1900273,GO:1990138,GO:1990253" tRNA binding|DNA damage checkpoint|positive regulation of defense response to virus by host|adaptive immune response|T cell activation involved in immune response|positive regulation of adaptive immune response|protein kinase activity|protein serine/threonine kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|ATP binding|cytosol|polysome|regulation of translational initiation|protein phosphorylation|cell cycle arrest|learning|long-term memory|regulation of translational initiation by eIF2 alpha phosphorylation|viral translation|cytosolic ribosome|negative regulation of translational initiation in response to stress|negative regulation of CREB transcription factor activity|cellular response to amino acid starvation|cellular response to UV|eiF2alpha phosphorylation in response to endoplasmic reticulum stress|induction by virus of host autophagy|negative regulation by host of viral genome replication|negative regulation of neuron differentiation|negative regulation of translational initiation|protein autophosphorylation|defense response to virus|regulation of feeding behavior|cellular response to cold|positive regulation of translational initiation in response to starvation|protein serine kinase activity|protein threonine kinase activity|GCN2-mediated signaling|positive regulation of long-term synaptic potentiation|neuron projection extension|cellular response to leucine starvation "hsa04140,hsa04141,hsa05160,hsa05162,hsa05168" Autophagy - animal|Protein processing in endoplasmic reticulum|Hepatitis C|Measles|Herpes simplex virus 1 infection EIF2B1 1073.542083 1016.98588 1130.098286 1.111223182 0.152148602 0.663485182 1 21.48800464 24.90653495 1967 eukaryotic translation initiation factor 2B subunit alpha "GO:0003743,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005851,GO:0005886,GO:0006413,GO:0006446,GO:0009408,GO:0009749,GO:0014003,GO:0016020,GO:0042802,GO:0043434,GO:0050790,GO:0050852" translation initiation factor activity|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|eukaryotic translation initiation factor 2B complex|plasma membrane|translational initiation|regulation of translational initiation|response to heat|response to glucose|oligodendrocyte development|membrane|identical protein binding|response to peptide hormone|regulation of catalytic activity|T cell receptor signaling pathway "hsa03013,hsa05168" RNA transport|Herpes simplex virus 1 infection EIF2B2 1039.512604 1115.436609 963.5885994 0.863866751 -0.211119297 0.547282126 1 13.12568058 11.82727024 8892 eukaryotic translation initiation factor 2B subunit beta "GO:0001541,GO:0003743,GO:0005085,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005829,GO:0005851,GO:0006413,GO:0006446,GO:0007417,GO:0009408,GO:0009749,GO:0014003,GO:0042552,GO:0043434,GO:0050790,GO:0050852" ovarian follicle development|translation initiation factor activity|guanyl-nucleotide exchange factor activity|protein binding|ATP binding|GTP binding|cytoplasm|cytosol|eukaryotic translation initiation factor 2B complex|translational initiation|regulation of translational initiation|central nervous system development|response to heat|response to glucose|oligodendrocyte development|myelination|response to peptide hormone|regulation of catalytic activity|T cell receptor signaling pathway "hsa03013,hsa05168" RNA transport|Herpes simplex virus 1 infection EIF2B3 429.9731539 431.3562866 428.5900212 0.993587052 -0.009281722 0.988771292 1 9.027551314 9.356034592 8891 eukaryotic translation initiation factor 2B subunit gamma "GO:0002183,GO:0003743,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005851,GO:0006413,GO:0008135,GO:0009408,GO:0009749,GO:0014003,GO:0021766,GO:0032045,GO:0043434,GO:0050790,GO:0050852" "cytoplasmic translational initiation|translation initiation factor activity|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|eukaryotic translation initiation factor 2B complex|translational initiation|translation factor activity, RNA binding|response to heat|response to glucose|oligodendrocyte development|hippocampus development|guanyl-nucleotide exchange factor complex|response to peptide hormone|regulation of catalytic activity|T cell receptor signaling pathway" "hsa03013,hsa05168" RNA transport|Herpes simplex virus 1 infection EIF2B4 588.2902014 578.524902 598.0555008 1.033759305 0.047900316 0.907202655 1 15.1972227 16.38700512 8890 eukaryotic translation initiation factor 2B subunit delta "GO:0001541,GO:0003743,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005851,GO:0006413,GO:0006417,GO:0009408,GO:0009749,GO:0014003,GO:0031369,GO:0042552,GO:0043434,GO:0050790,GO:0050852" ovarian follicle development|translation initiation factor activity|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|eukaryotic translation initiation factor 2B complex|translational initiation|regulation of translation|response to heat|response to glucose|oligodendrocyte development|translation initiation factor binding|myelination|response to peptide hormone|regulation of catalytic activity|T cell receptor signaling pathway "hsa03013,hsa05168" RNA transport|Herpes simplex virus 1 infection EIF2B5 1238.486036 1179.378835 1297.593237 1.100234461 0.137810996 0.686879814 1 22.92071274 26.30445399 8893 eukaryotic translation initiation factor 2B subunit epsilon "GO:0001541,GO:0003743,GO:0005085,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005851,GO:0006413,GO:0009408,GO:0009749,GO:0014002,GO:0014003,GO:0031369,GO:0034976,GO:0042552,GO:0043434,GO:0045948,GO:0048708,GO:0050790,GO:0050852" ovarian follicle development|translation initiation factor activity|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytoplasm|cytosol|eukaryotic translation initiation factor 2B complex|translational initiation|response to heat|response to glucose|astrocyte development|oligodendrocyte development|translation initiation factor binding|response to endoplasmic reticulum stress|myelination|response to peptide hormone|positive regulation of translational initiation|astrocyte differentiation|regulation of catalytic activity|T cell receptor signaling pathway "hsa03013,hsa05168" RNA transport|Herpes simplex virus 1 infection EIF2D 1108.415049 1009.881189 1206.94891 1.195139511 0.257179037 0.458273912 1 9.881553236 12.31855449 1939 eukaryotic translation initiation factor 2D "GO:0001731,GO:0003743,GO:0005737,GO:0005829,GO:0006886,GO:0016604,GO:0022627,GO:0032790,GO:0038023,GO:0075522" formation of translation preinitiation complex|translation initiation factor activity|cytoplasm|cytosol|intracellular protein transport|nuclear body|cytosolic small ribosomal subunit|ribosome disassembly|signaling receptor activity|IRES-dependent viral translational initiation EIF2S1 2040.106026 2062.390528 2017.821525 0.97838964 -0.031518968 0.923492585 1 25.14511424 25.66146155 1965 eukaryotic translation initiation factor 2 subunit alpha "GO:0003723,GO:0003743,GO:0005515,GO:0005634,GO:0005829,GO:0005844,GO:0005850,GO:0005851,GO:0006413,GO:0007568,GO:0010494,GO:0016020,GO:0032057,GO:0033290,GO:0034063,GO:0034198,GO:0034599,GO:0034605,GO:0034644,GO:0034976,GO:0036499,GO:0043022,GO:0043614,GO:0044207,GO:0045202,GO:0046777,GO:0055085,GO:0070062,GO:0097451,GO:1901216,GO:1905098,GO:1990737,GO:2000676" RNA binding|translation initiation factor activity|protein binding|nucleus|cytosol|polysome|eukaryotic translation initiation factor 2 complex|eukaryotic translation initiation factor 2B complex|translational initiation|aging|cytoplasmic stress granule|membrane|negative regulation of translational initiation in response to stress|eukaryotic 48S preinitiation complex|stress granule assembly|cellular response to amino acid starvation|cellular response to oxidative stress|cellular response to heat|cellular response to UV|response to endoplasmic reticulum stress|PERK-mediated unfolded protein response|ribosome binding|multi-eIF complex|translation initiation ternary complex|synapse|protein autophosphorylation|transmembrane transport|extracellular exosome|glial limiting end-foot|positive regulation of neuron death|negative regulation of guanyl-nucleotide exchange factor activity|response to manganese-induced endoplasmic reticulum stress|positive regulation of type B pancreatic cell apoptotic process "hsa03013,hsa04140,hsa04141,hsa04210,hsa04932,hsa05010,hsa05012,hsa05014,hsa05020,hsa05022,hsa05160,hsa05162,hsa05164,hsa05168" RNA transport|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Hepatitis C|Measles|Influenza A|Herpes simplex virus 1 infection EIF2S2 5478.41905 5075.794798 5881.043302 1.158644811 0.212438367 0.510335328 1 86.49767839 104.5371611 8894 eukaryotic translation initiation factor 2 subunit beta "GO:0001701,GO:0001731,GO:0001732,GO:0002176,GO:0003723,GO:0003729,GO:0003743,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005850,GO:0006413,GO:0008135,GO:0008584,GO:0031369,GO:0046872,GO:0055085" "in utero embryonic development|formation of translation preinitiation complex|formation of cytoplasmic translation initiation complex|male germ cell proliferation|RNA binding|mRNA binding|translation initiation factor activity|protein binding|nucleus|cytoplasm|cytosol|eukaryotic translation initiation factor 2 complex|translational initiation|translation factor activity, RNA binding|male gonad development|translation initiation factor binding|metal ion binding|transmembrane transport" hsa03013 RNA transport EIF2S3 6948.381357 6453.090047 7443.672667 1.15350516 0.206024458 0.52921185 1 94.54042399 113.7504221 1968 eukaryotic translation initiation factor 2 subunit gamma "GO:0000049,GO:0001731,GO:0003743,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005850,GO:0006413,GO:0008135,GO:0045296,GO:0045903,GO:0055085,GO:0070062" "tRNA binding|formation of translation preinitiation complex|translation initiation factor activity|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|eukaryotic translation initiation factor 2 complex|translational initiation|translation factor activity, RNA binding|cadherin binding|positive regulation of translational fidelity|transmembrane transport|extracellular exosome" hsa03013 RNA transport EIF2S3B 193.5287451 196.9014579 190.1560324 0.965742125 -0.050290086 0.93632626 1 3.146848916 3.169954274 255308 eukaryotic translation initiation factor 2 subunit gamma B "GO:0000049,GO:0001731,GO:0003743,GO:0003924,GO:0005525,GO:0005829,GO:0005850,GO:0045903" tRNA binding|formation of translation preinitiation complex|translation initiation factor activity|GTPase activity|GTP binding|cytosol|eukaryotic translation initiation factor 2 complex|positive regulation of translational fidelity EIF3A 6062.024175 6176.007068 5948.041283 0.963088484 -0.054259743 0.867627095 1 46.97296446 47.18783898 8661 eukaryotic translation initiation factor 3 subunit A "GO:0001732,GO:0002188,GO:0003723,GO:0003729,GO:0003743,GO:0005198,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005852,GO:0005874,GO:0006413,GO:0014069,GO:0016020,GO:0016282,GO:0030971,GO:0033290,GO:0043614,GO:0070373,GO:0071540,GO:0071541,GO:0075522,GO:0075525" "formation of cytoplasmic translation initiation complex|translation reinitiation|RNA binding|mRNA binding|translation initiation factor activity|structural molecule activity|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|microtubule|translational initiation|postsynaptic density|membrane|eukaryotic 43S preinitiation complex|receptor tyrosine kinase binding|eukaryotic 48S preinitiation complex|multi-eIF complex|negative regulation of ERK1 and ERK2 cascade|eukaryotic translation initiation factor 3 complex, eIF3e|eukaryotic translation initiation factor 3 complex, eIF3m|IRES-dependent viral translational initiation|viral translational termination-reinitiation" hsa03013 RNA transport EIF3B 3852.864145 4377.505092 3328.223199 0.760301388 -0.395356669 0.214786971 1 62.36432911 49.45816146 8662 eukaryotic translation initiation factor 3 subunit B "GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0016282,GO:0031369,GO:0033290,GO:0045202,GO:0060090,GO:0070062,GO:0071541,GO:0075522,GO:0075525" "formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|eukaryotic 43S preinitiation complex|translation initiation factor binding|eukaryotic 48S preinitiation complex|synapse|molecular adaptor activity|extracellular exosome|eukaryotic translation initiation factor 3 complex, eIF3m|IRES-dependent viral translational initiation|viral translational termination-reinitiation" hsa03013 RNA transport EIF3C 300.8077597 323.7709539 277.8445655 0.85815161 -0.220695543 0.644017377 1 4.976587745 4.454629792 8663 eukaryotic translation initiation factor 3 subunit C "GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016282,GO:0031369,GO:0033290,GO:0043022,GO:0045727,GO:1902416" formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|eukaryotic 43S preinitiation complex|translation initiation factor binding|eukaryotic 48S preinitiation complex|ribosome binding|positive regulation of translation|positive regulation of mRNA binding hsa03013 RNA transport EIF3CL 237.0194346 139.0489677 334.9899016 2.409150584 1.268524572 0.013882416 0.521881214 2.153620696 5.411891639 728689 eukaryotic translation initiation factor 3 subunit C like "GO:0001732,GO:0003743,GO:0005515,GO:0005852,GO:0006413,GO:0016282,GO:0031369,GO:0033290" formation of cytoplasmic translation initiation complex|translation initiation factor activity|protein binding|eukaryotic translation initiation factor 3 complex|translational initiation|eukaryotic 43S preinitiation complex|translation initiation factor binding|eukaryotic 48S preinitiation complex hsa03013 RNA transport EIF3D 5209.761544 5367.087161 5052.435928 0.941373929 -0.087160196 0.7868286 1 144.5872504 141.9737636 8664 eukaryotic translation initiation factor 3 subunit D "GO:0001732,GO:0002191,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016020,GO:0016282,GO:0033290,GO:0045727,GO:0071541,GO:0075522,GO:0075525,GO:0098808,GO:1902416" "formation of cytoplasmic translation initiation complex|cap-dependent translational initiation|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|membrane|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|positive regulation of translation|eukaryotic translation initiation factor 3 complex, eIF3m|IRES-dependent viral translational initiation|viral translational termination-reinitiation|mRNA cap binding|positive regulation of mRNA binding" hsa03013 RNA transport EIF3E 8611.349839 8395.71577 8826.983908 1.051367644 0.072267241 0.828111461 1 176.5103302 193.5711653 3646 eukaryotic translation initiation factor 3 subunit E "GO:0000184,GO:0000785,GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0016020,GO:0016282,GO:0016605,GO:0033290,GO:0045296,GO:0045727,GO:0045947,GO:0047485,GO:0070062,GO:0071540,GO:1902416" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|chromatin|formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|membrane|eukaryotic 43S preinitiation complex|PML body|eukaryotic 48S preinitiation complex|cadherin binding|positive regulation of translation|negative regulation of translational initiation|protein N-terminus binding|extracellular exosome|eukaryotic translation initiation factor 3 complex, eIF3e|positive regulation of mRNA binding" "hsa03013,hsa05160" RNA transport|Hepatitis C EIF3F 4761.464005 4659.662851 4863.26516 1.043694644 0.061699681 0.847808364 1 34.1033938 37.12675434 8665 eukaryotic translation initiation factor 3 subunit F "GO:0001732,GO:0003743,GO:0004843,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0008234,GO:0008237,GO:0016020,GO:0016282,GO:0016579,GO:0018215,GO:0031369,GO:0033290,GO:0042802,GO:0070122,GO:0071541,GO:0075522,GO:0101005" "formation of cytoplasmic translation initiation complex|translation initiation factor activity|thiol-dependent ubiquitin-specific protease activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|cysteine-type peptidase activity|metallopeptidase activity|membrane|eukaryotic 43S preinitiation complex|protein deubiquitination|protein phosphopantetheinylation|translation initiation factor binding|eukaryotic 48S preinitiation complex|identical protein binding|isopeptidase activity|eukaryotic translation initiation factor 3 complex, eIF3m|IRES-dependent viral translational initiation|ubiquitinyl hydrolase activity" hsa03013 RNA transport EIF3G 2199.686449 2093.854163 2305.518735 1.101088498 0.138930427 0.665250464 1 96.14354186 110.4226773 8666 eukaryotic translation initiation factor 3 subunit G "GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005852,GO:0006413,GO:0016282,GO:0033290,GO:0048471,GO:0075525" formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|nucleus|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|perinuclear region of cytoplasm|viral translational termination-reinitiation hsa03013 RNA transport EIF3H 7146.835932 7390.909362 6902.762502 0.933953072 -0.098578034 0.763963273 1 94.50226852 92.0625963 8667 eukaryotic translation initiation factor 3 subunit H "GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0006508,GO:0008237,GO:0016020,GO:0016282,GO:0018215,GO:0032435,GO:0033290,GO:0042788,GO:0070062,GO:0070122,GO:0101005" formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|proteolysis|metallopeptidase activity|membrane|eukaryotic 43S preinitiation complex|protein phosphopantetheinylation|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|eukaryotic 48S preinitiation complex|polysomal ribosome|extracellular exosome|isopeptidase activity|ubiquitinyl hydrolase activity "hsa03013,hsa05162" RNA transport|Measles EIF3I 3863.808942 3980.657308 3746.960576 0.941291924 -0.087285878 0.784571098 1 105.0579728 103.150011 8668 eukaryotic translation initiation factor 3 subunit I "GO:0001732,GO:0002183,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016282,GO:0033290,GO:0070062,GO:0071541" "formation of cytoplasmic translation initiation complex|cytoplasmic translational initiation|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|extracellular exosome|eukaryotic translation initiation factor 3 complex, eIF3m" hsa03013 RNA transport EIF3J 839.1706397 991.6119811 686.7292983 0.692538323 -0.530034187 0.14549986 1 20.25883366 14.63437499 8669 eukaryotic translation initiation factor 3 subunit J "GO:0001732,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016282,GO:0033290,GO:0042802" formation of cytoplasmic translation initiation complex|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|identical protein binding hsa03013 RNA transport EIF3K 2013.189404 2074.569999 1951.808809 0.940825718 -0.088000597 0.78577957 1 137.8866822 135.3154643 27335 eukaryotic translation initiation factor 3 subunit K "GO:0001732,GO:0003743,GO:0005515,GO:0005634,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0016020,GO:0016282,GO:0033290,GO:0043022" formation of cytoplasmic translation initiation complex|translation initiation factor activity|protein binding|nucleus|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|membrane|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|ribosome binding EIF3L 10001.56511 9777.070843 10226.05938 1.045922602 0.064776097 0.847529883 1 153.7807909 167.7712608 51386 eukaryotic translation initiation factor 3 subunit L "GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016020,GO:0016282,GO:0033290,GO:0075525" formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|membrane|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|viral translational termination-reinitiation EIF3M 3317.790839 3092.570836 3543.010842 1.145652284 0.19616924 0.53759089 1 30.47233519 36.41451181 10480 eukaryotic translation initiation factor 3 subunit M "GO:0001732,GO:0002183,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016032,GO:0016282,GO:0031369,GO:0033290,GO:0071541" "formation of cytoplasmic translation initiation complex|cytoplasmic translational initiation|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|viral process|eukaryotic 43S preinitiation complex|translation initiation factor binding|eukaryotic 48S preinitiation complex|eukaryotic translation initiation factor 3 complex, eIF3m" EIF4A1 22288.38994 24164.0717 20412.70818 0.844754495 -0.243395973 0.510385729 1 696.1461807 613.4043986 1973 eukaryotic translation initiation factor 4A1 "GO:0000339,GO:0002183,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0003743,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006413,GO:0008135,GO:0016020,GO:0016032,GO:0016281,GO:0070062" "RNA cap binding|cytoplasmic translational initiation|RNA binding|RNA helicase activity|double-stranded RNA binding|mRNA binding|translation initiation factor activity|helicase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|translational initiation|translation factor activity, RNA binding|membrane|viral process|eukaryotic translation initiation factor 4F complex|extracellular exosome" hsa03013 RNA transport EIF4A2 6536.17859 5215.858721 7856.498458 1.506271331 0.590981672 0.07065606 1 140.066195 220.0657574 1974 eukaryotic translation initiation factor 4A2 "GO:0002183,GO:0003723,GO:0003724,GO:0003743,GO:0004386,GO:0005515,GO:0005524,GO:0005829,GO:0006413,GO:0006446,GO:0016032,GO:0016281,GO:0016887,GO:0048471,GO:1900260,GO:1990830" cytoplasmic translational initiation|RNA binding|RNA helicase activity|translation initiation factor activity|helicase activity|protein binding|ATP binding|cytosol|translational initiation|regulation of translational initiation|viral process|eukaryotic translation initiation factor 4F complex|ATPase activity|perinuclear region of cytoplasm|negative regulation of RNA-directed 5'-3' RNA polymerase activity|cellular response to leukemia inhibitory factor hsa03013 RNA transport EIF4A3 1697.020971 1744.70931 1649.332633 0.945333772 -0.081104298 0.805415303 1 35.00925973 34.52105271 9775 eukaryotic translation initiation factor 4A3 "GO:0000184,GO:0000398,GO:0003723,GO:0003724,GO:0003729,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006405,GO:0006406,GO:0008143,GO:0008306,GO:0014070,GO:0016020,GO:0016607,GO:0017148,GO:0030425,GO:0031124,GO:0035145,GO:0035368,GO:0035613,GO:0035640,GO:0043021,GO:0043025,GO:0045182,GO:0045727,GO:0048701,GO:0071006,GO:0071013,GO:0072715,GO:0090394,GO:0098978,GO:0099524,GO:0099578,GO:1904570,GO:1904574,GO:1990416" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|mRNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|RNA export from nucleus|mRNA export from nucleus|poly(A) binding|associative learning|response to organic cyclic compound|membrane|nuclear speck|negative regulation of translation|dendrite|mRNA 3'-end processing|exon-exon junction complex|selenocysteine insertion sequence binding|RNA stem-loop binding|exploration behavior|ribonucleoprotein complex binding|neuronal cell body|translation regulator activity|positive regulation of translation|embryonic cranial skeleton morphogenesis|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome|cellular response to selenite ion|negative regulation of excitatory postsynaptic potential|glutamatergic synapse|postsynaptic cytosol|regulation of translation at postsynapse, modulating synaptic transmission|negative regulation of selenocysteine incorporation|negative regulation of selenocysteine insertion sequence binding|cellular response to brain-derived neurotrophic factor stimulus" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome EIF4B 14459.49715 12916.32965 16002.66465 1.238948299 0.309115985 0.375921642 1 169.6489966 219.2403107 1975 eukaryotic translation initiation factor 4B "GO:0001731,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0006413,GO:0006446,GO:0016281,GO:0033592,GO:0034057,GO:0043024,GO:0097010" formation of translation preinitiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|translational initiation|regulation of translational initiation|eukaryotic translation initiation factor 4F complex|RNA strand annealing activity|RNA strand-exchange activity|ribosomal small subunit binding|eukaryotic translation initiation factor 4F complex assembly "hsa03013,hsa04150,hsa04151,hsa05205" RNA transport|mTOR signaling pathway|PI3K-Akt signaling pathway|Proteoglycans in cancer EIF4E 708.5921752 821.0993784 596.084972 0.725959595 -0.462038842 0.220141958 1 13.85269382 10.48968905 1977 eukaryotic translation initiation factor 4E "GO:0000082,GO:0000339,GO:0000340,GO:0000932,GO:0001662,GO:0003723,GO:0003743,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005845,GO:0006405,GO:0006406,GO:0006413,GO:0006417,GO:0010494,GO:0010507,GO:0016032,GO:0016281,GO:0016442,GO:0017148,GO:0019827,GO:0019899,GO:0030324,GO:0031370,GO:0033391,GO:0036464,GO:0045665,GO:0045931,GO:0048471,GO:0070062,GO:0070491,GO:0071549,GO:0098978,GO:0099524,GO:0099578" "G1/S transition of mitotic cell cycle|RNA cap binding|RNA 7-methylguanosine cap binding|P-body|behavioral fear response|RNA binding|translation initiation factor activity|protein binding|nucleus|cytoplasm|cytosol|mRNA cap binding complex|RNA export from nucleus|mRNA export from nucleus|translational initiation|regulation of translation|cytoplasmic stress granule|negative regulation of autophagy|viral process|eukaryotic translation initiation factor 4F complex|RISC complex|negative regulation of translation|stem cell population maintenance|enzyme binding|lung development|eukaryotic initiation factor 4G binding|chromatoid body|cytoplasmic ribonucleoprotein granule|negative regulation of neuron differentiation|positive regulation of mitotic cell cycle|perinuclear region of cytoplasm|extracellular exosome|repressing transcription factor binding|cellular response to dexamethasone stimulus|glutamatergic synapse|postsynaptic cytosol|regulation of translation at postsynapse, modulating synaptic transmission" "hsa01521,hsa03013,hsa04066,hsa04150,hsa04151,hsa04211,hsa04910" EGFR tyrosine kinase inhibitor resistance|RNA transport|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Longevity regulating pathway|Insulin signaling pathway EIF4E2 1091.298369 1119.496433 1063.100305 0.949623665 -0.074572207 0.83214409 1 14.39414699 14.25782867 9470 eukaryotic translation initiation factor 4E family member 2 "GO:0000339,GO:0000340,GO:0000932,GO:0003723,GO:0003743,GO:0005515,GO:0005737,GO:0005829,GO:0005845,GO:0006413,GO:0008135,GO:0016281,GO:0017148,GO:0031047,GO:0031625,GO:1905618" "RNA cap binding|RNA 7-methylguanosine cap binding|P-body|RNA binding|translation initiation factor activity|protein binding|cytoplasm|cytosol|mRNA cap binding complex|translational initiation|translation factor activity, RNA binding|eukaryotic translation initiation factor 4F complex|negative regulation of translation|gene silencing by RNA|ubiquitin protein ligase binding|positive regulation of miRNA mediated inhibition of translation" "hsa01521,hsa03013,hsa04066,hsa04150,hsa04151,hsa04211,hsa04910" EGFR tyrosine kinase inhibitor resistance|RNA transport|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Longevity regulating pathway|Insulin signaling pathway EIF4E3 167.2910693 120.7797602 213.8023784 1.770183829 0.823899188 0.150208378 1 0.580918212 1.072628397 317649 eukaryotic translation initiation factor 4E family member 3 "GO:0000340,GO:0003743,GO:0005829,GO:0005845,GO:0006413,GO:0006417,GO:0016281" RNA 7-methylguanosine cap binding|translation initiation factor activity|cytosol|mRNA cap binding complex|translational initiation|regulation of translation|eukaryotic translation initiation factor 4F complex EIF4EBP1 1311.530452 1356.99613 1266.064775 0.932990705 -0.100065387 0.768456125 1 83.10407107 80.87523321 1978 eukaryotic translation initiation factor 4E binding protein 1 "GO:0000082,GO:0002931,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008190,GO:0030324,GO:0030371,GO:0031333,GO:0031929,GO:0032991,GO:0045471,GO:0045931,GO:0045947,GO:0051721,GO:0071456,GO:0098978,GO:0099524,GO:1990928" G1/S transition of mitotic cell cycle|response to ischemia|protein binding|nucleus|cytoplasm|cytosol|eukaryotic initiation factor 4E binding|lung development|translation repressor activity|negative regulation of protein-containing complex assembly|TOR signaling|protein-containing complex|response to ethanol|positive regulation of mitotic cell cycle|negative regulation of translational initiation|protein phosphatase 2A binding|cellular response to hypoxia|glutamatergic synapse|postsynaptic cytosol|response to amino acid starvation "hsa01521,hsa03013,hsa04012,hsa04066,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04910,hsa05163,hsa05165,hsa05168,hsa05221,hsa05231" EGFR tyrosine kinase inhibitor resistance|RNA transport|ErbB signaling pathway|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Insulin signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Acute myeloid leukemia|Choline metabolism in cancer EIF4EBP2 2777.547742 2599.302235 2955.79325 1.137148735 0.185420967 0.56065168 1 17.57382037 20.84487934 1979 eukaryotic translation initiation factor 4E binding protein 2 "GO:0005515,GO:0005737,GO:0006412,GO:0007613,GO:0008190,GO:0008286,GO:0019933,GO:0030371,GO:0031929,GO:0035176,GO:0045947,GO:0048167,GO:0050804,GO:0098794" protein binding|cytoplasm|translation|memory|eukaryotic initiation factor 4E binding|insulin receptor signaling pathway|cAMP-mediated signaling|translation repressor activity|TOR signaling|social behavior|negative regulation of translational initiation|regulation of synaptic plasticity|modulation of chemical synaptic transmission|postsynapse "hsa03013,hsa04213" RNA transport|Longevity regulating pathway - multiple species EIF4EBP3 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.074175959 0.300430959 8637 eukaryotic translation initiation factor 4E binding protein 3 "GO:0005515,GO:0005737,GO:0008190,GO:0016020,GO:0016281,GO:0030371,GO:0045947" protein binding|cytoplasm|eukaryotic initiation factor 4E binding|membrane|eukaryotic translation initiation factor 4F complex|translation repressor activity|negative regulation of translational initiation hsa03013 RNA transport EIF4ENIF1 707.2115181 726.7084734 687.7145627 0.946341742 -0.079566832 0.835969477 1 6.038592371 5.960732612 56478 eukaryotic translation initiation factor 4E nuclear import factor 1 "GO:0000932,GO:0003723,GO:0003729,GO:0005049,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006606,GO:0016020,GO:0016605,GO:0016607,GO:0017148,GO:0019827,GO:0019900,GO:0031047,GO:0033962,GO:0043231,GO:0045665,GO:0048255,GO:0051168,GO:0060213,GO:0106289,GO:1905618" P-body|RNA binding|mRNA binding|nuclear export signal receptor activity|protein binding|nucleus|cytoplasm|cytosol|protein import into nucleus|membrane|PML body|nuclear speck|negative regulation of translation|stem cell population maintenance|kinase binding|gene silencing by RNA|P-body assembly|intracellular membrane-bounded organelle|negative regulation of neuron differentiation|mRNA stabilization|nuclear export|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of miRNA mediated inhibition of translation EIF4G1 13311.80738 14643.78471 11979.83004 0.818082912 -0.289681028 0.402356913 1 119.9896514 102.3898821 1981 eukaryotic translation initiation factor 4 gamma 1 "GO:0000184,GO:0001662,GO:0002191,GO:0003723,GO:0003729,GO:0003743,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006412,GO:0006413,GO:0006446,GO:0008135,GO:0008190,GO:0010494,GO:0010507,GO:0010801,GO:0010942,GO:0016020,GO:0016032,GO:0016281,GO:0030307,GO:0031369,GO:0031669,GO:0032270,GO:0032502,GO:0033138,GO:0034645,GO:0036493,GO:0042802,GO:0043488,GO:0045666,GO:0060090,GO:0060964,GO:0080135,GO:0097009,GO:1900087,GO:1901215,GO:1905537,GO:1905606,GO:1905612,GO:1905618,GO:1905696" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|behavioral fear response|cap-dependent translational initiation|RNA binding|mRNA binding|translation initiation factor activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|polysome|translation|translational initiation|regulation of translational initiation|translation factor activity, RNA binding|eukaryotic initiation factor 4E binding|cytoplasmic stress granule|negative regulation of autophagy|negative regulation of peptidyl-threonine phosphorylation|positive regulation of cell death|membrane|viral process|eukaryotic translation initiation factor 4F complex|positive regulation of cell growth|translation initiation factor binding|cellular response to nutrient levels|positive regulation of cellular protein metabolic process|developmental process|positive regulation of peptidyl-serine phosphorylation|cellular macromolecule biosynthetic process|positive regulation of translation in response to endoplasmic reticulum stress|identical protein binding|regulation of mRNA stability|positive regulation of neuron differentiation|molecular adaptor activity|regulation of gene silencing by miRNA|regulation of cellular response to stress|energy homeostasis|positive regulation of G1/S transition of mitotic cell cycle|negative regulation of neuron death|positive regulation of eukaryotic translation initiation factor 4F complex assembly|regulation of presynapse assembly|positive regulation of mRNA cap binding|positive regulation of miRNA mediated inhibition of translation|regulation of polysome binding" "hsa03013,hsa05416" RNA transport|Viral myocarditis EIF4G2 15960.84813 15462.85418 16458.84208 1.064411647 0.090056201 0.79870682 1 184.2680034 204.5857958 1982 eukaryotic translation initiation factor 4 gamma 2 "GO:0003723,GO:0003729,GO:0003743,GO:0005515,GO:0005829,GO:0005912,GO:0006413,GO:0006446,GO:0007050,GO:0007507,GO:0008135,GO:0008219,GO:0010507,GO:0016020,GO:0016281,GO:0030307,GO:0030424,GO:0034645,GO:0045296,GO:0045727,GO:0045773,GO:0060999" "RNA binding|mRNA binding|translation initiation factor activity|protein binding|cytosol|adherens junction|translational initiation|regulation of translational initiation|cell cycle arrest|heart development|translation factor activity, RNA binding|cell death|negative regulation of autophagy|membrane|eukaryotic translation initiation factor 4F complex|positive regulation of cell growth|axon|cellular macromolecule biosynthetic process|cadherin binding|positive regulation of translation|positive regulation of axon extension|positive regulation of dendritic spine development" "hsa03013,hsa05416" RNA transport|Viral myocarditis EIF4G3 2649.991135 2534.345053 2765.637217 1.091263091 0.125998961 0.69313477 1 14.9372322 17.00260747 8672 eukaryotic translation initiation factor 4 gamma 3 "GO:0000339,GO:0003723,GO:0003729,GO:0003743,GO:0005829,GO:0006413,GO:0006446,GO:0008135,GO:0010507,GO:0016281" "RNA cap binding|RNA binding|mRNA binding|translation initiation factor activity|cytosol|translational initiation|regulation of translational initiation|translation factor activity, RNA binding|negative regulation of autophagy|eukaryotic translation initiation factor 4F complex" "hsa03013,hsa05416" RNA transport|Viral myocarditis EIF4H 8081.957521 8846.35622 7317.558822 0.827183378 -0.273720899 0.408154117 1 174.8094945 150.8282686 7458 eukaryotic translation initiation factor 4H "GO:0001731,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0006413,GO:0006446,GO:0008135,GO:0016020,GO:0016032,GO:0016281,GO:0019953,GO:0033592,GO:0034057,GO:0043024,GO:0045296,GO:0048471,GO:0048589,GO:0097010" "formation of translation preinitiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|translational initiation|regulation of translational initiation|translation factor activity, RNA binding|membrane|viral process|eukaryotic translation initiation factor 4F complex|sexual reproduction|RNA strand annealing activity|RNA strand-exchange activity|ribosomal small subunit binding|cadherin binding|perinuclear region of cytoplasm|developmental growth|eukaryotic translation initiation factor 4F complex assembly" EIF5 4421.989196 4555.122386 4288.856005 0.941545724 -0.086896937 0.786124813 1 38.39894796 37.71174869 1983 eukaryotic translation initiation factor 5 "GO:0001731,GO:0001732,GO:0003723,GO:0003743,GO:0005092,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006446,GO:0045296,GO:0071074,GO:0090630" formation of translation preinitiation complex|formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|GDP-dissociation inhibitor activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|plasma membrane|regulation of translational initiation|cadherin binding|eukaryotic initiation factor eIF2 binding|activation of GTPase activity hsa03013 RNA transport EIF5A 9951.737758 11759.27985 8144.195667 0.692576057 -0.529955583 0.115849854 1 164.8853932 119.114762 1984 eukaryotic translation initiation factor 5A "GO:0003723,GO:0003746,GO:0005515,GO:0005634,GO:0005642,GO:0005643,GO:0005737,GO:0005789,GO:0005829,GO:0006406,GO:0006414,GO:0006611,GO:0006913,GO:0006915,GO:0008284,GO:0016020,GO:0017070,GO:0043022,GO:0045901,GO:0045905,GO:0047485" RNA binding|translation elongation factor activity|protein binding|nucleus|annulate lamellae|nuclear pore|cytoplasm|endoplasmic reticulum membrane|cytosol|mRNA export from nucleus|translational elongation|protein export from nucleus|nucleocytoplasmic transport|apoptotic process|positive regulation of cell population proliferation|membrane|U6 snRNA binding|ribosome binding|positive regulation of translational elongation|positive regulation of translational termination|protein N-terminus binding EIF5A2 646.4168426 443.5357582 849.2979271 1.914835301 0.937220308 0.015309109 0.546932731 4.059183493 8.107482854 56648 eukaryotic translation initiation factor 5A2 "GO:0003746,GO:0005515,GO:0005643,GO:0005789,GO:0005829,GO:0006414,GO:0007283,GO:0008284,GO:0010509,GO:0015031,GO:0043022,GO:0043231,GO:0045901,GO:0045905,GO:0051028" translation elongation factor activity|protein binding|nuclear pore|endoplasmic reticulum membrane|cytosol|translational elongation|spermatogenesis|positive regulation of cell population proliferation|polyamine homeostasis|protein transport|ribosome binding|intracellular membrane-bounded organelle|positive regulation of translational elongation|positive regulation of translational termination|mRNA transport EIF5AL1 303.0576367 376.5486643 229.5666091 0.609659868 -0.713923513 0.130315712 1 4.879954315 3.103268077 143244 eukaryotic translation initiation factor 5A like 1 "GO:0003746,GO:0005643,GO:0005789,GO:0006414,GO:0015031,GO:0043022,GO:0045901,GO:0045905,GO:0051028" translation elongation factor activity|nuclear pore|endoplasmic reticulum membrane|translational elongation|protein transport|ribosome binding|positive regulation of translational elongation|positive regulation of translational termination|mRNA transport EIF5B 1900.349659 2039.04654 1761.652777 0.863959082 -0.210965109 0.514677754 1 17.9882449 16.21055543 9669 eukaryotic translation initiation factor 5B "GO:0003723,GO:0003743,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0006413,GO:0006446,GO:0046872" RNA binding|translation initiation factor activity|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|translational initiation|regulation of translational initiation|metal ion binding hsa03013 RNA transport EIF6 4372.345428 4461.746437 4282.944419 0.959925554 -0.059005572 0.854023262 1 185.0710212 185.3070337 3692 eukaryotic translation initiation factor 6 "GO:0000054,GO:0000460,GO:0000470,GO:0003743,GO:0005515,GO:0005634,GO:0005638,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006110,GO:0006413,GO:0030687,GO:0032868,GO:0035195,GO:0035278,GO:0042256,GO:0042304,GO:0043022,GO:0043023,GO:0045652,GO:0045727,GO:0070062,GO:1902626,GO:2000377" "ribosomal subunit export from nucleus|maturation of 5.8S rRNA|maturation of LSU-rRNA|translation initiation factor activity|protein binding|nucleus|lamin filament|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of glycolytic process|translational initiation|preribosome, large subunit precursor|response to insulin|gene silencing by miRNA|miRNA mediated inhibition of translation|mature ribosome assembly|regulation of fatty acid biosynthetic process|ribosome binding|ribosomal large subunit binding|regulation of megakaryocyte differentiation|positive regulation of translation|extracellular exosome|assembly of large subunit precursor of preribosome|regulation of reactive oxygen species metabolic process" hsa03008 Ribosome biogenesis in eukaryotes EIPR1 375.4866954 411.0571672 339.9162237 0.826931753 -0.274159827 0.536732846 1 7.745013168 6.680481391 7260 EARP complex and GARP complex interacting protein 1 "GO:0000938,GO:0005515,GO:0005802,GO:0016567,GO:0032456,GO:0050796,GO:1905281,GO:1990745,GO:2001137" "GARP complex|protein binding|trans-Golgi network|protein ubiquitination|endocytic recycling|regulation of insulin secretion|positive regulation of retrograde transport, endosome to Golgi|EARP complex|positive regulation of endocytic recycling" ELAC1 101.7116025 116.7199364 86.70326866 0.742831699 -0.428892714 0.529342032 1 2.673655818 2.071628406 55520 elaC ribonuclease Z 1 "GO:0005634,GO:0005654,GO:0005829,GO:0034414,GO:0042781,GO:0046872" "nucleus|nucleoplasm|cytosol|tRNA 3'-trailer cleavage, endonucleolytic|3'-tRNA processing endoribonuclease activity|metal ion binding" hsa03013 RNA transport ELAC2 2638.703648 2739.366159 2538.041137 0.926506714 -0.110126665 0.73034411 1 34.21436055 33.06533507 60528 elaC ribonuclease Z 2 "GO:0003723,GO:0004549,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0042645,GO:0042780,GO:0042781,GO:0046872,GO:0072684,GO:0090646" "RNA binding|tRNA-specific ribonuclease activity|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|mitochondrial nucleoid|tRNA 3'-end processing|3'-tRNA processing endoribonuclease activity|metal ion binding|mitochondrial tRNA 3'-trailer cleavage, endonucleolytic|mitochondrial tRNA processing" hsa03013 RNA transport ELAPOR1 16.65769882 27.40381115 5.911586499 0.215721327 -2.212759283 0.071396572 1 0.167925754 0.0377856 57535 endosome-lysosome associated apoptosis and autophagy regulator 1 "GO:0000045,GO:0003723,GO:0005764,GO:0005765,GO:0005770,GO:0005789,GO:0005802,GO:0005886,GO:0005887,GO:0009267,GO:0016021,GO:0031902,GO:0044090,GO:0070062,GO:2000786" autophagosome assembly|RNA binding|lysosome|lysosomal membrane|late endosome|endoplasmic reticulum membrane|trans-Golgi network|plasma membrane|integral component of plasma membrane|cellular response to starvation|integral component of membrane|late endosome membrane|positive regulation of vacuole organization|extracellular exosome|positive regulation of autophagosome assembly ELAPOR2 896.4604743 866.772397 926.1485516 1.06850259 0.095590406 0.79260581 1 5.227311755 5.825992365 222223 endosome-lysosome associated apoptosis and autophagy regulator family member 2 "GO:0005886,GO:0016021,GO:0030513,GO:0045684,GO:0051961,GO:0070700" plasma membrane|integral component of membrane|positive regulation of BMP signaling pathway|positive regulation of epidermis development|negative regulation of nervous system development|BMP receptor binding ELAVL1 2115.785072 2150.691697 2080.878448 0.967539165 -0.047608034 0.883466416 1 17.99222783 18.15805909 1994 ELAV like RNA binding protein 1 "GO:0000398,GO:0003723,GO:0003725,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006606,GO:0010494,GO:0016020,GO:0016441,GO:0019901,GO:0035198,GO:0035925,GO:0042803,GO:0043488,GO:0045727,GO:0048255,GO:0051260,GO:0060965,GO:0070935,GO:0098794,GO:0098978,GO:1990904,GO:2000036" "mRNA splicing, via spliceosome|RNA binding|double-stranded RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|protein import into nucleus|cytoplasmic stress granule|membrane|posttranscriptional gene silencing|protein kinase binding|miRNA binding|mRNA 3'-UTR AU-rich region binding|protein homodimerization activity|regulation of mRNA stability|positive regulation of translation|mRNA stabilization|protein homooligomerization|negative regulation of gene silencing by miRNA|3'-UTR-mediated mRNA stabilization|postsynapse|glutamatergic synapse|ribonucleoprotein complex|regulation of stem cell population maintenance" "hsa04152,hsa04657" AMPK signaling pathway|IL-17 signaling pathway ELF1 738.0164957 811.9647747 664.0682168 0.81785348 -0.29008569 0.43795399 1 8.747745458 7.462555486 1997 E74 like ETS transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001959,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030154,GO:0045893,GO:0045944,GO:0050855,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|regulation of cytokine-mediated signaling pathway|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of B cell receptor signaling pathway|sequence-specific double-stranded DNA binding" ETS ELF2 498.4760008 466.8797455 530.0722561 1.135350722 0.18313803 0.656857093 1 5.169613479 6.122151088 1998 E74 like ETS transcription factor 2 "GO:0000785,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0016604,GO:0030154,GO:0045893,GO:0050855,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|nuclear body|cell differentiation|positive regulation of transcription, DNA-templated|regulation of B cell receptor signaling pathway|sequence-specific double-stranded DNA binding" ETS ELF3 96.1117773 138.0340117 54.18954291 0.392581091 -1.348937409 0.051747534 1 2.181939993 0.893486737 1999 E74 like ETS transcription factor 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001824,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006357,GO:0006366,GO:0006954,GO:0030154,GO:0030198,GO:0030855,GO:0045747,GO:0045892,GO:0045944,GO:0060056,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blastocyst development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|inflammatory response|cell differentiation|extracellular matrix organization|epithelial cell differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|mammary gland involution|sequence-specific double-stranded DNA binding" ETS ELF4 1833.891816 1638.138933 2029.644698 1.238994237 0.309169478 0.340827419 1 13.98616958 18.07523723 2000 E74 like ETS transcription factor 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001787,GO:0001866,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0016604,GO:0016605,GO:0030154,GO:0045087,GO:0045893,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|natural killer cell proliferation|NK T cell proliferation|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nuclear body|PML body|cell differentiation|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" ELF5 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.104098702 0.021081273 2001 E74 like ETS transcription factor 5 "GO:0000785,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0030154,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|cell differentiation|sequence-specific double-stranded DNA binding" hsa04917 Prolactin signaling pathway ETS ELFN1 13.55344781 17.25425146 9.852644165 0.571027041 -0.808369028 0.542896236 1 0.091132231 0.054280596 392617 extracellular leucine rich repeat and fibronectin type III domain containing 1 "GO:0004864,GO:0005615,GO:0010923,GO:0016021,GO:0030425,GO:0031012,GO:0032515,GO:0050808,GO:0060076" protein phosphatase inhibitor activity|extracellular space|negative regulation of phosphatase activity|integral component of membrane|dendrite|extracellular matrix|negative regulation of phosphoprotein phosphatase activity|synapse organization|excitatory synapse ELFN2 723.8449685 685.0952787 762.5946584 1.113122046 0.154611783 0.682194336 1 4.145478972 4.813194708 114794 extracellular leucine rich repeat and fibronectin type III domain containing 2 "GO:0004864,GO:0005615,GO:0010923,GO:0016021,GO:0031012,GO:0032515" protein phosphatase inhibitor activity|extracellular space|negative regulation of phosphatase activity|integral component of membrane|extracellular matrix|negative regulation of phosphoprotein phosphatase activity ELK1 2011.541523 1961.909887 2061.173159 1.050595225 0.071206933 0.82626918 1 34.53730086 37.8477221 2002 ETS transcription factor ELK1 "GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001228,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0009416,GO:0030154,GO:0030425,GO:0043025,GO:0043679,GO:0045893,GO:0045944,GO:0071394,GO:0071480,GO:0071774,GO:1901216,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|response to light stimulus|cell differentiation|dendrite|neuronal cell body|axon terminus|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cellular response to testosterone stimulus|cellular response to gamma radiation|response to fibroblast growth factor|positive regulation of neuron death|sequence-specific double-stranded DNA binding" "hsa04010,hsa04012,hsa04014,hsa04510,hsa04910,hsa04912,hsa04921,hsa05140,hsa05161,hsa05163,hsa05166,hsa05200,hsa05205,hsa05213,hsa05225" MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Focal adhesion|Insulin signaling pathway|GnRH signaling pathway|Oxytocin signaling pathway|Leishmaniasis|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Endometrial cancer|Hepatocellular carcinoma ETS ELK3 3876.915779 3798.98019 3954.851368 1.041029742 0.058011287 0.856141957 1 44.01851856 47.79852439 2004 ETS transcription factor ELK3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001525,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0007165,GO:0030154,GO:0032422,GO:0042060,GO:0045892,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|signal transduction|cell differentiation|purine-rich negative regulatory element binding|wound healing|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" ETS ELK4 1055.052911 931.729579 1178.376242 1.264719151 0.33881705 0.332110287 1 3.983186987 5.254612796 2005 ETS transcription factor ELK4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0030154,GO:0045944,GO:0070932,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|cell differentiation|positive regulation of transcription by RNA polymerase II|histone H3 deacetylation|sequence-specific double-stranded DNA binding" "hsa04010,hsa05166,hsa05202" MAPK signaling pathway|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer ETS ELL 439.3898273 468.9096574 409.8699973 0.87409161 -0.194143605 0.648659733 1 4.811308738 4.386681544 8178 elongation factor for RNA polymerase II "GO:0001701,GO:0005515,GO:0005654,GO:0005829,GO:0006366,GO:0006368,GO:0008023,GO:0010923,GO:0015030,GO:0016604,GO:0016607,GO:0019902,GO:0032786,GO:0032968,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0045945" "in utero embryonic development|protein binding|nucleoplasm|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|negative regulation of phosphatase activity|Cajal body|nuclear body|nuclear speck|phosphatase binding|positive regulation of DNA-templated transcription, elongation|positive regulation of transcription elongation from RNA polymerase II promoter|transcriptionally active chromatin|histone locus body|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III|positive regulation of transcription by RNA polymerase III" ELL2 629.0072064 667.8410272 590.1733855 0.883703399 -0.178365862 0.646700867 1 4.58254871 4.224054811 22936 elongation factor for RNA polymerase II 2 "GO:0005515,GO:0005654,GO:0006368,GO:0008023,GO:0042795" protein binding|nucleoplasm|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|snRNA transcription by RNA polymerase II other ELL3 16.97218172 15.22433953 18.72002391 1.229611563 0.298202637 0.842951169 1 0.439349908 0.563500633 80237 elongation factor for RNA polymerase II 3 "GO:0000987,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006354,GO:0006366,GO:0006368,GO:0007283,GO:0008023,GO:0010717,GO:0016607,GO:0030054,GO:0032786,GO:0042795,GO:0045944,GO:0048863,GO:0050769,GO:1902166,GO:2000179" "cis-regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|DNA-templated transcription, elongation|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|spermatogenesis|transcription elongation factor complex|regulation of epithelial to mesenchymal transition|nuclear speck|cell junction|positive regulation of DNA-templated transcription, elongation|snRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|stem cell differentiation|positive regulation of neurogenesis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of neural precursor cell proliferation" ELMO1 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.018380431 0.012407548 9844 engulfment and cell motility 1 "GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006911,GO:0006915,GO:0007015,GO:0016020,GO:0016477,GO:0016601,GO:0017124,GO:0030036,GO:0032045,GO:0038096,GO:0048010,GO:0048870,GO:0050690,GO:0050790" "guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|plasma membrane|phagocytosis, engulfment|apoptotic process|actin filament organization|membrane|cell migration|Rac protein signal transduction|SH3 domain binding|actin cytoskeleton organization|guanyl-nucleotide exchange factor complex|Fc-gamma receptor signaling pathway involved in phagocytosis|vascular endothelial growth factor receptor signaling pathway|cell motility|regulation of defense response to virus by virus|regulation of catalytic activity" "hsa04062,hsa05100,hsa05131,hsa05132,hsa05135" Chemokine signaling pathway|Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Yersinia infection ELMO2 1759.380143 1697.006379 1821.753906 1.073510347 0.102336096 0.754520346 1 23.34892323 26.1450226 63916 engulfment and cell motility 2 "GO:0005515,GO:0005829,GO:0006915,GO:0007015,GO:0016020,GO:0017124,GO:0030971,GO:0038096,GO:0048010,GO:0048870,GO:0060326,GO:0098609" protein binding|cytosol|apoptotic process|actin filament organization|membrane|SH3 domain binding|receptor tyrosine kinase binding|Fc-gamma receptor signaling pathway involved in phagocytosis|vascular endothelial growth factor receptor signaling pathway|cell motility|cell chemotaxis|cell-cell adhesion "hsa05100,hsa05131,hsa05132,hsa05135" Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Yersinia infection ELMO3 27.07720408 32.47859099 21.67581716 0.667387855 -0.583402663 0.581356938 1 0.620024899 0.431621787 79767 engulfment and cell motility 3 "GO:0005515,GO:0005737,GO:0006909,GO:0006915,GO:0007015,GO:0016477,GO:0017124,GO:0048870" protein binding|cytoplasm|phagocytosis|apoptotic process|actin filament organization|cell migration|SH3 domain binding|cell motility hsa05100 Bacterial invasion of epithelial cells ELMOD1 58.67717268 71.04691779 46.30742758 0.65178658 -0.617528447 0.448561387 1 1.108184708 0.753413672 55531 ELMO domain containing 1 "GO:0005096,GO:0043547" GTPase activator activity|positive regulation of GTPase activity ELMOD2 365.3371358 390.7580478 339.9162237 0.869889246 -0.201096365 0.654728965 1 2.386124501 2.165075233 255520 ELMO domain containing 2 "GO:0005096,GO:0016020,GO:0043547,GO:0050688,GO:0051607" GTPase activator activity|membrane|positive regulation of GTPase activity|regulation of defense response to virus|defense response to virus ELMOD3 230.3128572 185.7369422 274.8887722 1.479989758 0.565587192 0.272571479 1 3.353625983 5.177132326 84173 ELMO domain containing 3 "GO:0005096,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0032420,GO:0043547,GO:0060091" GTPase activator activity|protein binding|cytoplasm|cytoskeleton|plasma membrane|stereocilium|positive regulation of GTPase activity|kinocilium ELOA 1002.426134 1173.289099 831.5631676 0.708745328 -0.496660775 0.15873633 1 12.02163742 8.887298436 6924 elongin A "GO:0005515,GO:0005615,GO:0005654,GO:0006357,GO:0006366,GO:0006368,GO:0070449,GO:0090734" protein binding|extracellular space|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|elongin complex|site of DNA damage ELOB 1652.310207 1752.828957 1551.791456 0.885306835 -0.175750536 0.592523901 1 91.14435635 84.16655066 6923 elongin B "GO:0005515,GO:0005654,GO:0005829,GO:0006366,GO:0006368,GO:0016032,GO:0016567,GO:0030891,GO:0031462,GO:0031466,GO:0031625,GO:0032436,GO:0043687,GO:0061418,GO:0065003,GO:0070449" protein binding|nucleoplasm|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|viral process|protein ubiquitination|VCB complex|Cul2-RING ubiquitin ligase complex|Cul5-RING ubiquitin ligase complex|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|regulation of transcription from RNA polymerase II promoter in response to hypoxia|protein-containing complex assembly|elongin complex "hsa04066,hsa04120,hsa05170,hsa05200,hsa05211" HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection|Pathways in cancer|Renal cell carcinoma ELOC 2319.856048 2495.776726 2143.93537 0.859025308 -0.21922746 0.493152694 1 51.88928022 46.49428088 6921 elongin C "GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0006368,GO:0006511,GO:0016032,GO:0016567,GO:0030891,GO:0031462,GO:0043687,GO:0044877,GO:0061418,GO:0070449" protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|viral process|protein ubiquitination|VCB complex|Cul2-RING ubiquitin ligase complex|post-translational protein modification|protein-containing complex binding|regulation of transcription from RNA polymerase II promoter in response to hypoxia|elongin complex "hsa04066,hsa04120,hsa05170,hsa05200,hsa05211" HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection|Pathways in cancer|Renal cell carcinoma ELOF1 639.7384729 694.2298824 585.2470634 0.843016238 -0.246367675 0.523705054 1 22.08561209 19.42054035 84337 elongation factor 1 homolog "GO:0000993,GO:0005515,GO:0006368,GO:0008023,GO:0046872,GO:0048096" RNA polymerase II complex binding|protein binding|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|metal ion binding|chromatin-mediated maintenance of transcription ELOVL1 3170.744949 2941.342396 3400.147502 1.155984936 0.209122598 0.511056283 1 87.88708905 105.9725012 64834 ELOVL fatty acid elongase 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0016020,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0036109,GO:0042761,GO:0043651,GO:0046513,GO:0061436,GO:0102336,GO:0102337,GO:0102338,GO:0102756" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|membrane|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|linoleic acid metabolic process|ceramide biosynthetic process|establishment of skin barrier|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL3 25.45084969 22.3290313 28.57266808 1.279619688 0.355715095 0.758670687 1 0.444181722 0.59286734 83401 ELOVL fatty acid elongase 3 "GO:0005515,GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0036109,GO:0042761,GO:0043651,GO:0102336,GO:0102337,GO:0102338,GO:0102756,GO:0120162" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|linoleic acid metabolic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity|positive regulation of cold-induced thermogenesis" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL4 207.802955 162.3929549 253.2129551 1.559260715 0.640862173 0.229229595 1 2.729714663 4.439682566 6785 ELOVL fatty acid elongase 4 "GO:0005515,GO:0005783,GO:0006633,GO:0006636,GO:0008020,GO:0009584,GO:0009922,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0042761,GO:0102336,GO:0102337,GO:0102338,GO:0102756" "protein binding|endoplasmic reticulum|fatty acid biosynthetic process|unsaturated fatty acid biosynthetic process|G protein-coupled photoreceptor activity|detection of visible light|fatty acid elongase activity|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL5 2592.20075 2389.20635 2795.19515 1.169926218 0.226417549 0.477777858 1 32.55444525 39.72690232 60481 ELOVL fatty acid elongase 5 "GO:0005515,GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0016020,GO:0019367,GO:0030148,GO:0030176,GO:0030425,GO:0034625,GO:0034626,GO:0035338,GO:0036109,GO:0042761,GO:0043025,GO:0043651,GO:0045723,GO:0097447,GO:0102336,GO:0102337,GO:0102338,GO:0102756" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|membrane|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|dendrite|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|neuronal cell body|linoleic acid metabolic process|positive regulation of fatty acid biosynthetic process|dendritic tree|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL6 635.1105502 512.552764 757.6683363 1.478225052 0.563865929 0.144265341 1 3.883750646 5.988358975 79071 ELOVL fatty acid elongase 6 "GO:0005515,GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0009923,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0042759,GO:0042761,GO:0045540,GO:0102336,GO:0102337,GO:0102338,GO:0102756,GO:0120162" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|fatty acid elongase complex|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|long-chain fatty acid biosynthetic process|very long-chain fatty acid biosynthetic process|regulation of cholesterol biosynthetic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity|positive regulation of cold-induced thermogenesis" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL7 605.4338515 504.4331163 706.4345867 1.400452436 0.485892986 0.213190534 1 4.274344622 6.243869647 79993 ELOVL fatty acid elongase 7 "GO:0005515,GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0042761,GO:0102336,GO:0102337,GO:0102338,GO:0102756" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELP1 1777.243071 1773.128077 1781.358065 1.004641508 0.006680788 0.985562875 1 15.67510593 16.42621609 8518 elongator acetyltransferase complex subunit 1 "GO:0000049,GO:0002926,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0033588" tRNA binding|tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation|protein binding|nucleus|cytoplasm|cytosol|elongator holoenzyme complex ELP2 1345.863528 1380.340117 1311.386938 0.95004624 -0.073930361 0.827800961 1 8.103553655 8.030381638 55250 elongator acetyltransferase complex subunit 2 "GO:0000993,GO:0002098,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006368,GO:0008023,GO:0019901,GO:0033588,GO:0046425" RNA polymerase II complex binding|tRNA wobble uridine modification|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|protein kinase binding|elongator holoenzyme complex|regulation of receptor signaling pathway via JAK-STAT ELP3 524.1562181 605.9287131 442.383723 0.730092028 -0.453849768 0.261270623 1 8.983650975 6.841422425 55140 elongator acetyltransferase complex subunit 3 "GO:0000049,GO:0001764,GO:0002098,GO:0002926,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006357,GO:0007417,GO:0008080,GO:0008607,GO:0016407,GO:0030335,GO:0033588,GO:0045859,GO:0046872,GO:0051539,GO:0106261" "tRNA binding|neuron migration|tRNA wobble uridine modification|tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation|protein binding|nucleus|nucleolus|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|central nervous system development|N-acetyltransferase activity|phosphorylase kinase regulator activity|acetyltransferase activity|positive regulation of cell migration|elongator holoenzyme complex|regulation of protein kinase activity|metal ion binding|4 iron, 4 sulfur cluster binding|tRNA uridine(34) acetyltransferase activity" ELP4 397.8953988 393.8029157 401.987882 1.020784423 0.029678219 0.9517054 1 2.339832054 2.491349459 26610 elongator acetyltransferase complex subunit 4 "GO:0000993,GO:0002098,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0006368,GO:0008023,GO:0008607,GO:0033588,GO:0045859" RNA polymerase II complex binding|tRNA wobble uridine modification|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|phosphorylase kinase regulator activity|elongator holoenzyme complex|regulation of protein kinase activity ELP5 922.1070407 868.8023089 975.4117724 1.122708541 0.166983447 0.641893163 1 24.84572106 29.0960853 23587 elongator acetyltransferase complex subunit 5 "GO:0000049,GO:0002098,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006400,GO:0030335,GO:0033588" tRNA binding|tRNA wobble uridine modification|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|tRNA modification|positive regulation of cell migration|elongator holoenzyme complex ELP6 937.4353006 906.3556798 968.5149215 1.068581511 0.09569696 0.790585607 1 9.431624769 10.51259902 54859 elongator acetyltransferase complex subunit 6 "GO:0002098,GO:0003674,GO:0005634,GO:0005829,GO:0008150,GO:0030335,GO:0033588" tRNA wobble uridine modification|molecular_function|nucleus|cytosol|biological_process|positive regulation of cell migration|elongator holoenzyme complex EMB 932.3753665 897.221076 967.529657 1.078362605 0.108842374 0.762423446 1 10.45824679 11.76358337 133418 embigin "GO:0005886,GO:0005887,GO:0007156,GO:0007411,GO:0030424,GO:0035879,GO:0045202,GO:0070593,GO:0098632" plasma membrane|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|axon|plasma membrane lactate transport|synapse|dendrite self-avoidance|cell-cell adhesion mediator activity EMC1 2085.812696 2290.755621 1880.869771 0.821069587 -0.284423597 0.376267883 1 17.4490436 14.94402286 23065 ER membrane protein complex subunit 1 "GO:0005789,GO:0016021,GO:0030176,GO:0032977,GO:0032991,GO:0045050,GO:0071816,GO:0072546" endoplasmic reticulum membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|membrane insertase activity|protein-containing complex|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC10 1075.584119 1055.554207 1095.614031 1.037951461 0.053738978 0.879769946 1 5.009379387 5.423465709 284361 ER membrane protein complex subunit 10 "GO:0001525,GO:0001938,GO:0005576,GO:0010595,GO:0016021,GO:0030176,GO:0032977,GO:0045050,GO:0045766,GO:0071816,GO:0072546,GO:1900745" angiogenesis|positive regulation of endothelial cell proliferation|extracellular region|positive regulation of endothelial cell migration|integral component of membrane|integral component of endoplasmic reticulum membrane|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|positive regulation of angiogenesis|tail-anchored membrane protein insertion into ER membrane|EMC complex|positive regulation of p38MAPK cascade EMC2 737.9828448 674.945719 801.0199707 1.18679169 0.24706673 0.509278326 1 8.537367533 10.56852562 9694 ER membrane protein complex subunit 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0032977,GO:0042406,GO:0045050,GO:0071816,GO:0072546" protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|membrane insertase activity|extrinsic component of endoplasmic reticulum membrane|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC3 1500.815781 1600.585562 1401.046 0.875333399 -0.192095476 0.562896049 1 29.95713681 27.35204057 55831 ER membrane protein complex subunit 3 "GO:0003674,GO:0005515,GO:0016021,GO:0030176,GO:0032977,GO:0045050,GO:0071816,GO:0072546" molecular_function|protein binding|integral component of membrane|integral component of endoplasmic reticulum membrane|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC4 1145.185553 1166.184408 1124.186699 0.963987078 -0.052914288 0.880282906 1 57.96185103 58.28132119 51234 ER membrane protein complex subunit 4 "GO:0005515,GO:0006915,GO:0016021,GO:0030176,GO:0032977,GO:0045050,GO:0071816,GO:0072546" protein binding|apoptotic process|integral component of membrane|integral component of endoplasmic reticulum membrane|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC6 550.0160685 555.1809147 544.8512224 0.981394007 -0.027095634 0.950723084 1 42.86273593 43.87723175 83460 ER membrane protein complex subunit 6 "GO:0000045,GO:0005515,GO:0016021,GO:0030176,GO:0032977,GO:0045050,GO:0071816,GO:0072546,GO:0097631" autophagosome assembly|protein binding|integral component of membrane|integral component of endoplasmic reticulum membrane|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex|integral component of omegasome membrane EMC7 907.0257157 915.4902835 898.5611479 0.981508121 -0.02692789 0.943360657 1 43.37357643 44.40532582 56851 ER membrane protein complex subunit 7 "GO:0005515,GO:0016021,GO:0030176,GO:0030246,GO:0032977,GO:0045050,GO:0071816,GO:0072546" protein binding|integral component of membrane|integral component of endoplasmic reticulum membrane|carbohydrate binding|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC8 578.1230743 590.7043736 565.5417751 0.957402383 -0.062802697 0.877556593 1 12.93432453 12.91677776 10328 ER membrane protein complex subunit 8 "GO:0005515,GO:0005737,GO:0005829,GO:0016020,GO:0032977,GO:0045050,GO:0071816,GO:0072546" protein binding|cytoplasm|cytosol|membrane|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC9 434.2259728 452.6703619 415.7815838 0.918508519 -0.122634992 0.776398031 1 20.18147615 19.33535043 51016 ER membrane protein complex subunit 9 "GO:0005515,GO:0005737,GO:0032977,GO:0045050,GO:0071816,GO:0072546" protein binding|cytoplasm|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMD 2091.366746 2097.913987 2084.819505 0.993758333 -0.009033043 0.979222329 1 79.29249435 82.19185702 2010 emerin "GO:0003779,GO:0005515,GO:0005635,GO:0005637,GO:0005640,GO:0005654,GO:0005737,GO:0005783,GO:0005819,GO:0005874,GO:0006936,GO:0007084,GO:0007517,GO:0016020,GO:0016021,GO:0031616,GO:0031965,GO:0032541,GO:0035914,GO:0045296,GO:0046827,GO:0048147,GO:0048487,GO:0060828,GO:0071363,GO:0071763,GO:0090090" actin binding|protein binding|nuclear envelope|nuclear inner membrane|nuclear outer membrane|nucleoplasm|cytoplasm|endoplasmic reticulum|spindle|microtubule|muscle contraction|mitotic nuclear envelope reassembly|muscle organ development|membrane|integral component of membrane|spindle pole centrosome|nuclear membrane|cortical endoplasmic reticulum|skeletal muscle cell differentiation|cadherin binding|positive regulation of protein export from nucleus|negative regulation of fibroblast proliferation|beta-tubulin binding|regulation of canonical Wnt signaling pathway|cellular response to growth factor stimulus|nuclear membrane organization|negative regulation of canonical Wnt signaling pathway "hsa05410,hsa05412,hsa05414" Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy EME1 465.3508766 458.7600977 471.9416555 1.028733009 0.040868602 0.927064314 1 12.23516616 13.12890412 146956 essential meiotic structure-specific endonuclease 1 "GO:0000712,GO:0000792,GO:0003677,GO:0004519,GO:0005515,GO:0005654,GO:0005730,GO:0006302,GO:0031297,GO:0031573,GO:0036297,GO:0046872,GO:0048476,GO:0072429,GO:0090305" resolution of meiotic recombination intermediates|heterochromatin|DNA binding|endonuclease activity|protein binding|nucleoplasm|nucleolus|double-strand break repair|replication fork processing|intra-S DNA damage checkpoint|interstrand cross-link repair|metal ion binding|Holliday junction resolvase complex|response to intra-S DNA damage checkpoint signaling|nucleic acid phosphodiester bond hydrolysis "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway EME2 38.73435194 54.80762229 22.66108158 0.413465876 -1.274159827 0.167077423 1 1.364706352 0.588565519 197342 essential meiotic structure-specific endonuclease subunit 2 "GO:0000712,GO:0003677,GO:0004519,GO:0005515,GO:0005634,GO:0006302,GO:0031297,GO:0031573,GO:0048476,GO:0090305" resolution of meiotic recombination intermediates|DNA binding|endonuclease activity|protein binding|nucleus|double-strand break repair|replication fork processing|intra-S DNA damage checkpoint|Holliday junction resolvase complex|nucleic acid phosphodiester bond hydrolysis hsa03460 Fanconi anemia pathway EMG1 1233.242509 1225.051854 1241.433165 1.013371933 0.019163776 0.957686276 1 12.73231165 13.45835754 10436 EMG1 N1-specific pseudouridine methyltransferase "GO:0001824,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0006364,GO:0017126,GO:0019843,GO:0032040,GO:0042274,GO:0042802,GO:0070037,GO:0070475" blastocyst development|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytoplasm|rRNA processing|nucleologenesis|rRNA binding|small-subunit processome|ribosomal small subunit biogenesis|identical protein binding|rRNA (pseudouridine) methyltransferase activity|rRNA base methylation hsa03008 Ribosome biogenesis in eukaryotes EMID1 10.89729169 4.059823873 17.7347595 4.368356867 2.12709072 0.134038196 1 0.036257407 0.16520789 129080 EMI domain containing 1 "GO:0005576,GO:0005581" extracellular region|collagen trimer EMILIN1 26.09193966 32.47859099 19.70528833 0.606716232 -0.720906186 0.494172706 1 0.422860169 0.267607525 11117 elastin microfibril interfacer 1 "GO:0003180,GO:0005201,GO:0005515,GO:0005576,GO:0005581,GO:0005615,GO:0007155,GO:0007160,GO:0010628,GO:0010629,GO:0010811,GO:0016477,GO:0016525,GO:0030023,GO:0030512,GO:0030948,GO:0032966,GO:0034668,GO:0042802,GO:0048251,GO:0050866,GO:0060394,GO:0062023,GO:0070062,GO:0070373,GO:0098640,GO:1901203,GO:1904027,GO:1905522,GO:1990971" aortic valve morphogenesis|extracellular matrix structural constituent|protein binding|extracellular region|collagen trimer|extracellular space|cell adhesion|cell-matrix adhesion|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell-substrate adhesion|cell migration|negative regulation of angiogenesis|extracellular matrix constituent conferring elasticity|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of vascular endothelial growth factor receptor signaling pathway|negative regulation of collagen biosynthetic process|integrin alpha4-beta1 complex|identical protein binding|elastic fiber assembly|negative regulation of cell activation|negative regulation of pathway-restricted SMAD protein phosphorylation|collagen-containing extracellular matrix|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|integrin binding involved in cell-matrix adhesion|positive regulation of extracellular matrix assembly|negative regulation of collagen fibril organization|negative regulation of macrophage migration|EMILIN complex EMILIN2 98.14441084 108.6002886 87.68853307 0.80744291 -0.308567837 0.658993185 1 0.889283993 0.748976567 84034 elastin microfibril interfacer 2 "GO:0005515,GO:0005576,GO:0005581,GO:0007155,GO:0008150,GO:0030023,GO:0062023" protein binding|extracellular region|collagen trimer|cell adhesion|biological_process|extracellular matrix constituent conferring elasticity|collagen-containing extracellular matrix EMILIN3 33.24389037 16.23929549 50.24848524 3.094252781 1.629591061 0.094349892 1 0.216951471 0.700219691 90187 elastin microfibril interfacer 3 "GO:0005515,GO:0005737,GO:0030023,GO:0042802,GO:0062023" protein binding|cytoplasm|extracellular matrix constituent conferring elasticity|identical protein binding|collagen-containing extracellular matrix EML1 5.552566274 9.134603715 1.970528833 0.215721327 -2.212759283 0.247208451 1 0.088695447 0.019957693 2009 EMAP like 1 "GO:0000226,GO:0005509,GO:0005515,GO:0005829,GO:0005874,GO:0005875,GO:0007052,GO:0007405,GO:0007420,GO:0008017,GO:0015630,GO:0015631,GO:0048471,GO:0072686,GO:0097431,GO:1990023" microtubule cytoskeleton organization|calcium ion binding|protein binding|cytosol|microtubule|microtubule associated complex|mitotic spindle organization|neuroblast proliferation|brain development|microtubule binding|microtubule cytoskeleton|tubulin binding|perinuclear region of cytoplasm|mitotic spindle|mitotic spindle pole|mitotic spindle midzone EML2 773.0933436 684.0803227 862.1063645 1.260241431 0.333700144 0.367388015 1 8.931749176 11.7410301 24139 EMAP like 2 "GO:0000226,GO:0005102,GO:0005515,GO:0005737,GO:0005874,GO:0005875,GO:0007601,GO:0007605,GO:0008017,GO:0008022,GO:0010968,GO:0015631,GO:0031115,GO:0072686" microtubule cytoskeleton organization|signaling receptor binding|protein binding|cytoplasm|microtubule|microtubule associated complex|visual perception|sensory perception of sound|microtubule binding|protein C-terminus binding|regulation of microtubule nucleation|tubulin binding|negative regulation of microtubule polymerization|mitotic spindle EML3 1046.586367 959.1333901 1134.039343 1.18235832 0.241667318 0.490100685 1 15.00671072 18.50761907 256364 EMAP like 3 "GO:0000226,GO:0005515,GO:0005634,GO:0005737,GO:0005819,GO:0005876,GO:0007080,GO:0008017,GO:0015630,GO:0030496,GO:0072686,GO:1901673,GO:1990498" microtubule cytoskeleton organization|protein binding|nucleus|cytoplasm|spindle|spindle microtubule|mitotic metaphase plate congression|microtubule binding|microtubule cytoskeleton|midbody|mitotic spindle|regulation of mitotic spindle assembly|mitotic spindle microtubule EML4 1319.100807 1335.682054 1302.519559 0.975171864 -0.036271593 0.916582936 1 11.59937998 11.79863776 27436 EMAP like 4 "GO:0000226,GO:0000278,GO:0003674,GO:0005515,GO:0005737,GO:0005815,GO:0005874,GO:0007017,GO:0007080,GO:0008017,GO:0008608,GO:0016020,GO:0030496,GO:0043014,GO:0048487,GO:0072686" microtubule cytoskeleton organization|mitotic cell cycle|molecular_function|protein binding|cytoplasm|microtubule organizing center|microtubule|microtubule-based process|mitotic metaphase plate congression|microtubule binding|attachment of spindle microtubules to kinetochore|membrane|midbody|alpha-tubulin binding|beta-tubulin binding|mitotic spindle "hsa05200,hsa05223,hsa05235" Pathways in cancer|Non-small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer EML5 38.1971824 51.76275439 24.63161041 0.475855868 -1.071403433 0.246622533 1 0.218012549 0.108211359 161436 EMAP like 5 "GO:0003674,GO:0003824,GO:0005737,GO:0005874,GO:0008017,GO:0008150,GO:0070062" molecular_function|catalytic activity|cytoplasm|microtubule|microtubule binding|biological_process|extracellular exosome EML6 66.73743733 83.22638941 50.24848524 0.60375664 -0.727960944 0.349308539 1 0.42092301 0.26508217 400954 EMAP like 6 "GO:0005737,GO:0005874,GO:0008017" cytoplasm|microtubule|microtubule binding EMP1 4045.190875 3751.277259 4339.10449 1.156700556 0.210015431 0.510185337 1 66.63941054 80.4022164 2012 epithelial membrane protein 1 "GO:0005515,GO:0005886,GO:0008219,GO:0008544,GO:0016021,GO:0032060" protein binding|plasma membrane|cell death|epidermis development|integral component of membrane|bleb assembly EMP2 127.4229952 55.82257826 199.0234121 3.565285201 1.834017488 0.004340682 0.243721434 0.537595866 1.999245497 2013 epithelial membrane protein 2 "GO:0000139,GO:0001765,GO:0001913,GO:0001952,GO:0001954,GO:0003093,GO:0005178,GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0005901,GO:0007015,GO:0007155,GO:0007160,GO:0007566,GO:0008219,GO:0008283,GO:0008284,GO:0009986,GO:0010594,GO:0016021,GO:0016324,GO:0016477,GO:0019900,GO:0019901,GO:0031410,GO:0032060,GO:0032147,GO:0034394,GO:0043534,GO:0043549,GO:0045022,GO:0045121,GO:0045177,GO:0045765,GO:0070252,GO:0070836,GO:0072659,GO:2001046,GO:2001212" Golgi membrane|membrane raft assembly|T cell mediated cytotoxicity|regulation of cell-matrix adhesion|positive regulation of cell-matrix adhesion|regulation of glomerular filtration|integrin binding|protein binding|nucleus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|caveola|actin filament organization|cell adhesion|cell-matrix adhesion|embryo implantation|cell death|cell population proliferation|positive regulation of cell population proliferation|cell surface|regulation of endothelial cell migration|integral component of membrane|apical plasma membrane|cell migration|kinase binding|protein kinase binding|cytoplasmic vesicle|bleb assembly|activation of protein kinase activity|protein localization to cell surface|blood vessel endothelial cell migration|regulation of kinase activity|early endosome to late endosome transport|membrane raft|apical part of cell|regulation of angiogenesis|actin-mediated cell contraction|caveola assembly|protein localization to plasma membrane|positive regulation of integrin-mediated signaling pathway|regulation of vasculogenesis EMP3 1698.928158 1605.660342 1792.195974 1.11617378 0.158561662 0.628349664 1 107.0013578 124.5767609 2014 epithelial membrane protein 3 "GO:0005515,GO:0005886,GO:0008219,GO:0016021,GO:0032060" protein binding|plasma membrane|cell death|integral component of membrane|bleb assembly EMSY 1137.979663 1111.376785 1164.58254 1.047873733 0.067464884 0.847105597 1 7.780939104 8.504658903 56946 "EMSY transcriptional repressor, BRCA2 interacting" "GO:0005515,GO:0005654,GO:0006281,GO:0006325,GO:0006355,GO:0042802" "protein binding|nucleoplasm|DNA repair|chromatin organization|regulation of transcription, DNA-templated|identical protein binding" EN1 10.49373413 10.14955968 10.83790858 1.067820568 0.094669242 1 1 0.211800327 0.235907005 2019 engrailed homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001501,GO:0005634,GO:0006357,GO:0008344,GO:0009653,GO:0009953,GO:0009954,GO:0016020,GO:0021549,GO:0030182,GO:0030901,GO:0030917,GO:0035115,GO:0035176,GO:0035264,GO:0042220,GO:0042756,GO:0043473,GO:0043524,GO:0045944,GO:0048666,GO:0061743,GO:0071542,GO:1990403,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|nucleus|regulation of transcription by RNA polymerase II|adult locomotory behavior|anatomical structure morphogenesis|dorsal/ventral pattern formation|proximal/distal pattern formation|membrane|cerebellum development|neuron differentiation|midbrain development|midbrain-hindbrain boundary development|embryonic forelimb morphogenesis|social behavior|multicellular organism growth|response to cocaine|drinking behavior|pigmentation|negative regulation of neuron apoptotic process|positive regulation of transcription by RNA polymerase II|neuron development|motor learning|dopaminergic neuron differentiation|embryonic brain development|sequence-specific double-stranded DNA binding" ENAH 1522.94489 1901.012529 1144.877252 0.602246032 -0.731575112 0.027544268 0.734583991 6.35173362 3.990085053 55740 ENAH actin regulator "GO:0003779,GO:0005515,GO:0005522,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007411,GO:0008154,GO:0017124,GO:0030027,GO:0030054,GO:0030175,GO:0045202,GO:0050699,GO:0070358" actin binding|protein binding|profilin binding|cytosol|cytoskeleton|plasma membrane|focal adhesion|axon guidance|actin polymerization or depolymerization|SH3 domain binding|lamellipodium|cell junction|filopodium|synapse|WW domain binding|actin polymerization-dependent cell motility "hsa04015,hsa04360,hsa04810" Rap1 signaling pathway|Axon guidance|Regulation of actin cytoskeleton ENC1 1078.886562 1382.370029 775.4030958 0.560922965 -0.834125444 0.016970737 0.570200991 13.92168727 8.145373899 8507 ectodermal-neural cortex 1 "GO:0003779,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005856,GO:0007275,GO:0007399,GO:0010499,GO:0010976,GO:0016363,GO:0016567,GO:0017148,GO:0031463,GO:0043025" actin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytoskeleton|multicellular organism development|nervous system development|proteasomal ubiquitin-independent protein catabolic process|positive regulation of neuron projection development|nuclear matrix|protein ubiquitination|negative regulation of translation|Cul3-RING ubiquitin ligase complex|neuronal cell body ENDOD1 1129.410436 1300.158595 958.6622773 0.737342568 -0.439593047 0.203165104 1 14.15791145 10.88891051 23052 endonuclease domain containing 1 "GO:0002576,GO:0003676,GO:0004519,GO:0005515,GO:0005576,GO:0005829,GO:0016020,GO:0046872,GO:0070062,GO:0090305" platelet degranulation|nucleic acid binding|endonuclease activity|protein binding|extracellular region|cytosol|membrane|metal ion binding|extracellular exosome|nucleic acid phosphodiester bond hydrolysis ENDOG 283.8058864 306.5167024 261.0950704 0.851813517 -0.231390471 0.634275472 1 11.33137931 10.06800064 2021 endonuclease G "GO:0000014,GO:0001701,GO:0003676,GO:0004519,GO:0004521,GO:0005515,GO:0005634,GO:0005743,GO:0005829,GO:0006309,GO:0006310,GO:0007568,GO:0009612,GO:0032355,GO:0034612,GO:0036475,GO:0043065,GO:0043204,GO:0046677,GO:0046872,GO:0071277,GO:0071333,GO:0071456,GO:0090502,GO:1901300,GO:1902512" "single-stranded DNA endodeoxyribonuclease activity|in utero embryonic development|nucleic acid binding|endonuclease activity|endoribonuclease activity|protein binding|nucleus|mitochondrial inner membrane|cytosol|apoptotic DNA fragmentation|DNA recombination|aging|response to mechanical stimulus|response to estradiol|response to tumor necrosis factor|neuron death in response to oxidative stress|positive regulation of apoptotic process|perikaryon|response to antibiotic|metal ion binding|cellular response to calcium ion|cellular response to glucose stimulus|cellular response to hypoxia|RNA phosphodiester bond hydrolysis, endonucleolytic|positive regulation of hydrogen peroxide-mediated programmed cell death|positive regulation of apoptotic DNA fragmentation" hsa04210 Apoptosis ENDOV 121.5059655 122.8096722 120.2022588 0.978768664 -0.030960181 0.975499009 1 1.29851287 1.325690808 284131 endonuclease V "GO:0000287,GO:0003677,GO:0003727,GO:0005515,GO:0005730,GO:0005737,GO:0006281,GO:0010494,GO:0016888,GO:0016891,GO:0090502" "magnesium ion binding|DNA binding|single-stranded RNA binding|protein binding|nucleolus|cytoplasm|DNA repair|cytoplasmic stress granule|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|endoribonuclease activity, producing 5'-phosphomonoesters|RNA phosphodiester bond hydrolysis, endonucleolytic" ENG 2262.629802 2389.20635 2136.053255 0.894043018 -0.161583845 0.614118059 1 36.90298048 34.41405029 2022 endoglin "GO:0001525,GO:0001569,GO:0001570,GO:0001837,GO:0001934,GO:0001947,GO:0002040,GO:0003148,GO:0003198,GO:0003203,GO:0003208,GO:0003209,GO:0003222,GO:0003273,GO:0004888,GO:0005024,GO:0005114,GO:0005515,GO:0005534,GO:0005539,GO:0005615,GO:0005886,GO:0005925,GO:0006355,GO:0007155,GO:0007179,GO:0009897,GO:0009986,GO:0010629,GO:0010665,GO:0010862,GO:0015026,GO:0016021,GO:0016477,GO:0016604,GO:0017015,GO:0022009,GO:0030336,GO:0030509,GO:0030513,GO:0031953,GO:0031960,GO:0032967,GO:0034713,GO:0035912,GO:0036122,GO:0042493,GO:0042802,GO:0042803,GO:0043235,GO:0045766,GO:0045944,GO:0048185,GO:0048745,GO:0048844,GO:0048845,GO:0050431,GO:0051897,GO:0055009,GO:0060348,GO:0070278,GO:0071260,GO:0072563,GO:0090500,GO:0097084,GO:1905007,GO:1905065,GO:1905222,GO:1905310,GO:2000136" "angiogenesis|branching involved in blood vessel morphogenesis|vasculogenesis|epithelial to mesenchymal transition|positive regulation of protein phosphorylation|heart looping|sprouting angiogenesis|outflow tract septum morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|endocardial cushion morphogenesis|cardiac ventricle morphogenesis|cardiac atrium morphogenesis|ventricular trabecula myocardium morphogenesis|cell migration involved in endocardial cushion formation|transmembrane signaling receptor activity|transforming growth factor beta-activated receptor activity|type II transforming growth factor beta receptor binding|protein binding|galactose binding|glycosaminoglycan binding|extracellular space|plasma membrane|focal adhesion|regulation of transcription, DNA-templated|cell adhesion|transforming growth factor beta receptor signaling pathway|external side of plasma membrane|cell surface|negative regulation of gene expression|regulation of cardiac muscle cell apoptotic process|positive regulation of pathway-restricted SMAD protein phosphorylation|coreceptor activity|integral component of membrane|cell migration|nuclear body|regulation of transforming growth factor beta receptor signaling pathway|central nervous system vasculogenesis|negative regulation of cell migration|BMP signaling pathway|positive regulation of BMP signaling pathway|negative regulation of protein autophosphorylation|response to corticosteroid|positive regulation of collagen biosynthetic process|type I transforming growth factor beta receptor binding|dorsal aorta morphogenesis|BMP binding|response to drug|identical protein binding|protein homodimerization activity|receptor complex|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|activin binding|smooth muscle tissue development|artery morphogenesis|venous blood vessel morphogenesis|transforming growth factor beta binding|positive regulation of protein kinase B signaling|atrial cardiac muscle tissue morphogenesis|bone development|extracellular matrix constituent secretion|cellular response to mechanical stimulus|endothelial microparticle|endocardial cushion to mesenchymal transition|vascular associated smooth muscle cell development|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of vascular associated smooth muscle cell differentiation|atrioventricular canal morphogenesis|regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|regulation of cell proliferation involved in heart morphogenesis" ENGASE 346.7858586 334.9354696 358.6362476 1.070762222 0.098638145 0.832779404 1 3.234184929 3.61221689 64772 endo-beta-N-acetylglucosaminidase "GO:0004553,GO:0005829,GO:0006457,GO:0006517,GO:0033925" "hydrolase activity, hydrolyzing O-glycosyl compounds|cytosol|protein folding|protein deglycosylation|mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity" hsa00511 Other glycan degradation ENHO 7.045308675 10.14955968 3.941057666 0.388298388 -1.364762376 0.421596647 1 0.50003832 0.202527874 375704 energy homeostasis associated "GO:0005179,GO:0005576,GO:0005886,GO:0007165,GO:0045747,GO:0046627,GO:0046676,GO:0051055,GO:1903026" hormone activity|extracellular region|plasma membrane|signal transduction|positive regulation of Notch signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|negative regulation of lipid biosynthetic process|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding ENKD1 291.7555497 210.0958855 373.4152139 1.777356149 0.829732799 0.082775451 1 4.834445899 8.962663582 84080 enkurin domain containing 1 "GO:0005515,GO:0005881,GO:0015630,GO:0097546" protein binding|cytoplasmic microtubule|microtubule cytoskeleton|ciliary base ENKUR 5.552566274 9.134603715 1.970528833 0.215721327 -2.212759283 0.247208451 1 0.122325609 0.027524941 219670 "enkurin, TRPC channel interacting protein" "GO:0001669,GO:0005515,GO:0005516,GO:0017124,GO:0030317,GO:0061966,GO:0097228,GO:0097728,GO:0097729" acrosomal vesicle|protein binding|calmodulin binding|SH3 domain binding|flagellated sperm motility|establishment of left/right asymmetry|sperm principal piece|9+0 motile cilium|9+2 motile cilium ENO1 42747.71371 56012.37503 29483.0524 0.526366761 -0.925859707 0.026902946 0.724502122 897.4467559 492.7346209 2023 enolase 1 "GO:0000015,GO:0000122,GO:0000287,GO:0000977,GO:0001227,GO:0003723,GO:0004634,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006094,GO:0006096,GO:0009615,GO:0009986,GO:0010756,GO:0016020,GO:0030308,GO:0031430,GO:0032889,GO:0042803,GO:0045296,GO:0045892,GO:0045933,GO:0051020,GO:0061621,GO:0070062,GO:0099738,GO:1903298,GO:2001171" "phosphopyruvate hydratase complex|negative regulation of transcription by RNA polymerase II|magnesium ion binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|RNA binding|phosphopyruvate hydratase activity|protein binding|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|gluconeogenesis|glycolytic process|response to virus|cell surface|positive regulation of plasminogen activation|membrane|negative regulation of cell growth|M band|regulation of vacuole fusion, non-autophagic|protein homodimerization activity|cadherin binding|negative regulation of transcription, DNA-templated|positive regulation of muscle contraction|GTPase binding|canonical glycolysis|extracellular exosome|cell cortex region|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|positive regulation of ATP biosynthetic process" "hsa00010,hsa03018,hsa04066" Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENO2 3024.595994 3693.424769 2355.76722 0.637827319 -0.648762202 0.041992699 0.939853769 81.54269177 54.25054312 2026 enolase 2 "GO:0000015,GO:0000287,GO:0001917,GO:0004634,GO:0005515,GO:0005615,GO:0005829,GO:0005886,GO:0006094,GO:0006096,GO:0016020,GO:0032889,GO:0043204,GO:0061621,GO:0070062" "phosphopyruvate hydratase complex|magnesium ion binding|photoreceptor inner segment|phosphopyruvate hydratase activity|protein binding|extracellular space|cytosol|plasma membrane|gluconeogenesis|glycolytic process|membrane|regulation of vacuole fusion, non-autophagic|perikaryon|canonical glycolysis|extracellular exosome" "hsa00010,hsa03018,hsa04066" Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENO3 114.4430894 145.1387035 83.74747541 0.577016836 -0.793314682 0.221743458 1 4.471267222 2.691132248 2027 enolase 3 "GO:0000015,GO:0000287,GO:0004634,GO:0005615,GO:0005829,GO:0005886,GO:0006094,GO:0006096,GO:0007568,GO:0016020,GO:0032889,GO:0042493,GO:0042802,GO:0043403,GO:0044877,GO:0061621,GO:0070062" "phosphopyruvate hydratase complex|magnesium ion binding|phosphopyruvate hydratase activity|extracellular space|cytosol|plasma membrane|gluconeogenesis|glycolytic process|aging|membrane|regulation of vacuole fusion, non-autophagic|response to drug|identical protein binding|skeletal muscle tissue regeneration|protein-containing complex binding|canonical glycolysis|extracellular exosome" "hsa00010,hsa03018,hsa04066" Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENO4 7.463712004 5.074779842 9.852644165 1.941491941 0.957165719 0.581982097 1 0.054685042 0.110743965 387712 enolase 4 "GO:0000015,GO:0000287,GO:0003674,GO:0004634,GO:0005575,GO:0006096,GO:0008150,GO:0032889" "phosphopyruvate hydratase complex|magnesium ion binding|molecular_function|phosphopyruvate hydratase activity|cellular_component|glycolytic process|biological_process|regulation of vacuole fusion, non-autophagic" "hsa00010,hsa03018,hsa04066" Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENOPH1 598.7960597 623.1829646 574.4091548 0.921734366 -0.117577053 0.766798337 1 15.366124 14.77359004 58478 enolase-phosphatase 1 "GO:0000287,GO:0005515,GO:0005634,GO:0005829,GO:0016311,GO:0019284,GO:0019509,GO:0043715,GO:0043716,GO:0043874" "magnesium ion binding|protein binding|nucleus|cytosol|dephosphorylation|L-methionine salvage from S-adenosylmethionine|L-methionine salvage from methylthioadenosine|2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity" hsa00270 Cysteine and methionine metabolism ENOSF1 665.9667461 702.3495301 629.5839622 0.896396929 -0.157790388 0.681618369 1 6.152114486 5.752289019 55556 enolase superfamily member 1 "GO:0000287,GO:0005575,GO:0005739,GO:0009063,GO:0016052,GO:0016836,GO:0016853,GO:0044275,GO:0050023" magnesium ion binding|cellular_component|mitochondrion|cellular amino acid catabolic process|carbohydrate catabolic process|hydro-lyase activity|isomerase activity|cellular carbohydrate catabolic process|L-fuconate dehydratase activity hsa00051 Fructose and mannose metabolism ENOX1 39.60085015 46.68797455 32.51372575 0.696404718 -0.522002118 0.577442658 1 0.173802367 0.126250562 55068 ecto-NOX disulfide-thiol exchanger 1 "GO:0003676,GO:0005515,GO:0005615,GO:0005886,GO:0007624,GO:0009897,GO:0016491,GO:0055114" nucleic acid binding|protein binding|extracellular space|plasma membrane|ultradian rhythm|external side of plasma membrane|oxidoreductase activity|oxidation-reduction process ENOX2 378.5639765 385.683268 371.444685 0.963082187 -0.054269176 0.907902353 1 3.451757716 3.467524866 10495 ecto-NOX disulfide-thiol exchanger 2 "GO:0003676,GO:0005615,GO:0005829,GO:0007624,GO:0009897,GO:0015035,GO:0040008,GO:0055114" nucleic acid binding|extracellular space|cytosol|ultradian rhythm|external side of plasma membrane|protein disulfide oxidoreductase activity|regulation of growth|oxidation-reduction process ENPEP 27.4362243 23.34398727 31.52846133 1.350603089 0.433603763 0.690361961 1 0.248798528 0.350502786 2028 glutamyl aminopeptidase "GO:0001525,GO:0002003,GO:0003081,GO:0004177,GO:0005737,GO:0005765,GO:0005886,GO:0005887,GO:0005903,GO:0006508,GO:0007165,GO:0007267,GO:0008217,GO:0008270,GO:0008283,GO:0009897,GO:0016324,GO:0016477,GO:0031410,GO:0032835,GO:0042277,GO:0043171,GO:0045177,GO:0070006,GO:0070062" angiogenesis|angiotensin maturation|regulation of systemic arterial blood pressure by renin-angiotensin|aminopeptidase activity|cytoplasm|lysosomal membrane|plasma membrane|integral component of plasma membrane|brush border|proteolysis|signal transduction|cell-cell signaling|regulation of blood pressure|zinc ion binding|cell population proliferation|external side of plasma membrane|apical plasma membrane|cell migration|cytoplasmic vesicle|glomerulus development|peptide binding|peptide catabolic process|apical part of cell|metalloaminopeptidase activity|extracellular exosome hsa04614 Renin-angiotensin system ENPP1 260.6548942 273.0231555 248.286633 0.909397712 -0.13701672 0.787728746 1 1.859056152 1.763446525 5167 ectonucleotide pyrophosphatase/phosphodiesterase 1 "GO:0003676,GO:0004527,GO:0004528,GO:0004551,GO:0005044,GO:0005158,GO:0005509,GO:0005515,GO:0005524,GO:0005615,GO:0005765,GO:0005886,GO:0005887,GO:0006091,GO:0006771,GO:0006796,GO:0006897,GO:0006955,GO:0008270,GO:0009143,GO:0009986,GO:0016021,GO:0016323,GO:0030247,GO:0030308,GO:0030318,GO:0030500,GO:0030502,GO:0030505,GO:0030643,GO:0030730,GO:0031214,GO:0031953,GO:0032869,GO:0035529,GO:0036218,GO:0042803,GO:0045599,GO:0045719,GO:0046034,GO:0046325,GO:0046627,GO:0047429,GO:0050427,GO:0050656,GO:0090305,GO:0106177,GO:1990787" nucleic acid binding|exonuclease activity|phosphodiesterase I activity|nucleotide diphosphatase activity|scavenger receptor activity|insulin receptor binding|calcium ion binding|protein binding|ATP binding|extracellular space|lysosomal membrane|plasma membrane|integral component of plasma membrane|generation of precursor metabolites and energy|riboflavin metabolic process|phosphate-containing compound metabolic process|endocytosis|immune response|zinc ion binding|nucleoside triphosphate catabolic process|cell surface|integral component of membrane|basolateral plasma membrane|polysaccharide binding|negative regulation of cell growth|melanocyte differentiation|regulation of bone mineralization|negative regulation of bone mineralization|inorganic diphosphate transport|cellular phosphate ion homeostasis|sequestering of triglyceride|biomineral tissue development|negative regulation of protein autophosphorylation|cellular response to insulin stimulus|NADH pyrophosphatase activity|dTTP diphosphatase activity|protein homodimerization activity|negative regulation of fat cell differentiation|negative regulation of glycogen biosynthetic process|ATP metabolic process|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|nucleoside-triphosphate diphosphatase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|3'-phosphoadenosine 5'-phosphosulfate binding|nucleic acid phosphodiester bond hydrolysis|cyclic-GMP-AMP hydrolase activity|negative regulation of hh target transcription factor activity "hsa00230,hsa00240,hsa00500,hsa00740,hsa00760,hsa00770" Purine metabolism|Pyrimidine metabolism|Starch and sucrose metabolism|Riboflavin metabolism|Nicotinate and nicotinamide metabolism|Pantothenate and CoA biosynthesis ENPP2 13.94215959 10.14955968 17.7347595 1.747342747 0.805162625 0.540804743 1 0.148695225 0.27101358 5168 ectonucleotide pyrophosphatase/phosphodiesterase 2 "GO:0003676,GO:0004528,GO:0004551,GO:0004622,GO:0005044,GO:0005509,GO:0005615,GO:0005886,GO:0006897,GO:0006935,GO:0006955,GO:0008134,GO:0008270,GO:0009395,GO:0010634,GO:0016787,GO:0030149,GO:0030247,GO:0030334,GO:0034638,GO:0045765,GO:0047391,GO:0048870,GO:0050731,GO:0090305,GO:2000394" nucleic acid binding|phosphodiesterase I activity|nucleotide diphosphatase activity|lysophospholipase activity|scavenger receptor activity|calcium ion binding|extracellular space|plasma membrane|endocytosis|chemotaxis|immune response|transcription factor binding|zinc ion binding|phospholipid catabolic process|positive regulation of epithelial cell migration|hydrolase activity|sphingolipid catabolic process|polysaccharide binding|regulation of cell migration|phosphatidylcholine catabolic process|regulation of angiogenesis|alkylglycerophosphoethanolamine phosphodiesterase activity|cell motility|positive regulation of peptidyl-tyrosine phosphorylation|nucleic acid phosphodiester bond hydrolysis|positive regulation of lamellipodium morphogenesis hsa00565 Ether lipid metabolism ENPP3 3.970749218 2.029911937 5.911586499 2.912237912 1.542128219 0.515744462 1 0.028243923 0.085796149 5169 ectonucleotide pyrophosphatase/phosphodiesterase 3 "GO:0002276,GO:0003676,GO:0004528,GO:0005509,GO:0006220,GO:0006796,GO:0008270,GO:0009143,GO:0009897,GO:0016021,GO:0016324,GO:0030505,GO:0033007,GO:0035529,GO:0036218,GO:0046034,GO:0047429,GO:0048471,GO:0050728,GO:0070062,GO:0070667,GO:0090305" basophil activation involved in immune response|nucleic acid binding|phosphodiesterase I activity|calcium ion binding|pyrimidine nucleotide metabolic process|phosphate-containing compound metabolic process|zinc ion binding|nucleoside triphosphate catabolic process|external side of plasma membrane|integral component of membrane|apical plasma membrane|inorganic diphosphate transport|negative regulation of mast cell activation involved in immune response|NADH pyrophosphatase activity|dTTP diphosphatase activity|ATP metabolic process|nucleoside-triphosphate diphosphatase activity|perinuclear region of cytoplasm|negative regulation of inflammatory response|extracellular exosome|negative regulation of mast cell proliferation|nucleic acid phosphodiester bond hydrolysis "hsa00230,hsa00240,hsa00500,hsa00740,hsa00760,hsa00770" Purine metabolism|Pyrimidine metabolism|Starch and sucrose metabolism|Riboflavin metabolism|Nicotinate and nicotinamide metabolism|Pantothenate and CoA biosynthesis ENPP4 195.4223235 225.320225 165.524422 0.734618572 -0.444932725 0.414260763 1 2.457294253 1.882933571 22875 ectonucleotide pyrophosphatase/phosphodiesterase 4 "GO:0005515,GO:0005886,GO:0007596,GO:0016020,GO:0016021,GO:0030194,GO:0043312,GO:0046130,GO:0046872,GO:0047710,GO:0070062,GO:0101003" protein binding|plasma membrane|blood coagulation|membrane|integral component of membrane|positive regulation of blood coagulation|neutrophil degranulation|purine ribonucleoside catabolic process|metal ion binding|bis(5'-adenosyl)-triphosphatase activity|extracellular exosome|ficolin-1-rich granule membrane hsa00230 Purine metabolism ENPP5 6.419064483 1.014955968 11.823173 11.64895165 3.542128219 0.075977894 1 0.013358612 0.162317039 59084 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 "GO:0000210,GO:0005576,GO:0005886,GO:0007154,GO:0008270,GO:0016021" NAD+ diphosphatase activity|extracellular region|plasma membrane|cell communication|zinc ion binding|integral component of membrane ENSA 3527.654635 3429.536217 3625.773053 1.057219642 0.080275135 0.801409814 1 34.61417113 38.1711364 2029 endosulfine alpha "GO:0000086,GO:0000278,GO:0004864,GO:0005102,GO:0005515,GO:0005654,GO:0005737,GO:0007584,GO:0008200,GO:0019212,GO:0019870,GO:0019888,GO:0032515,GO:0035308,GO:0050796,GO:0051301,GO:0051721" G2/M transition of mitotic cell cycle|mitotic cell cycle|protein phosphatase inhibitor activity|signaling receptor binding|protein binding|nucleoplasm|cytoplasm|response to nutrient|ion channel inhibitor activity|phosphatase inhibitor activity|potassium channel inhibitor activity|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|regulation of insulin secretion|cell division|protein phosphatase 2A binding ENTPD1 18.07621234 23.34398727 12.80843742 0.548682505 -0.865956519 0.463554687 1 0.07248425 0.041484006 953 ectonucleoside triphosphate diphosphohydrolase 1 "GO:0004382,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0007155,GO:0007596,GO:0009134,GO:0016020,GO:0017110,GO:0034656,GO:0045134,GO:0070062,GO:0102485,GO:0102486,GO:0102487,GO:0102488,GO:0102489,GO:0102490,GO:0102491" guanosine-diphosphatase activity|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|cell adhesion|blood coagulation|nucleoside diphosphate catabolic process|membrane|nucleoside-diphosphatase activity|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|extracellular exosome|dATP phosphohydrolase activity|dCTP phosphohydrolase activity|dUTP phosphohydrolase activity|dTTP phosphohydrolase activity|GTP phosphohydrolase activity|8-oxo-dGTP phosphohydrolase activity|dGTP phosphohydrolase activity "hsa00230,hsa00240,hsa05169" Purine metabolism|Pyrimidine metabolism|Epstein-Barr virus infection ENTPD2 23.42093776 18.26920743 28.57266808 1.563979619 0.645221712 0.559318094 1 0.443775015 0.723952157 954 ectonucleoside triphosphate diphosphohydrolase 2 "GO:0004382,GO:0005515,GO:0005524,GO:0005604,GO:0005789,GO:0005886,GO:0007186,GO:0009134,GO:0009181,GO:0016020,GO:0016021,GO:0017110,GO:0017111,GO:0030168,GO:0034656,GO:0045134,GO:0070062" guanosine-diphosphatase activity|protein binding|ATP binding|basement membrane|endoplasmic reticulum membrane|plasma membrane|G protein-coupled receptor signaling pathway|nucleoside diphosphate catabolic process|purine ribonucleoside diphosphate catabolic process|membrane|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|platelet activation|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|extracellular exosome "hsa00230,hsa04742" Purine metabolism|Taste transduction ENTPD3 19.03178521 21.31407534 16.74949508 0.785841976 -0.347688863 0.794651386 1 0.20038662 0.164255482 956 ectonucleoside triphosphate diphosphohydrolase 3 "GO:0004382,GO:0005515,GO:0005524,GO:0005886,GO:0009134,GO:0009143,GO:0016020,GO:0016021,GO:0017110,GO:0017111,GO:0034656,GO:0045134,GO:0102485,GO:0102486,GO:0102487,GO:0102488,GO:0102489,GO:0102490,GO:0102491" guanosine-diphosphatase activity|protein binding|ATP binding|plasma membrane|nucleoside diphosphate catabolic process|nucleoside triphosphate catabolic process|membrane|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|dATP phosphohydrolase activity|dCTP phosphohydrolase activity|dUTP phosphohydrolase activity|dTTP phosphohydrolase activity|GTP phosphohydrolase activity|8-oxo-dGTP phosphohydrolase activity|dGTP phosphohydrolase activity "hsa00230,hsa00240,hsa05169" Purine metabolism|Pyrimidine metabolism|Epstein-Barr virus infection ENTPD4 1710.097871 1931.461208 1488.734533 0.770781483 -0.375606182 0.250314952 1 16.85709054 13.55282472 9583 ectonucleoside triphosphate diphosphohydrolase 4 "GO:0000139,GO:0004382,GO:0005794,GO:0006256,GO:0009134,GO:0016020,GO:0017110,GO:0017111,GO:0030173,GO:0031410,GO:0034656,GO:0036384,GO:0043273,GO:0045134,GO:0046036,GO:0046712,GO:0097637" Golgi membrane|guanosine-diphosphatase activity|Golgi apparatus|UDP catabolic process|nucleoside diphosphate catabolic process|membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|integral component of Golgi membrane|cytoplasmic vesicle|nucleobase-containing small molecule catabolic process|cytidine-diphosphatase activity|CTPase activity|uridine-diphosphatase activity|CTP metabolic process|GDP catabolic process|integral component of autophagosome membrane "hsa00230,hsa00240,hsa04142" Purine metabolism|Pyrimidine metabolism|Lysosome ENTPD5 524.3168 650.5867757 398.0468243 0.611827414 -0.708803345 0.079687182 1 3.610950691 2.304445385 957 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) "GO:0004382,GO:0005515,GO:0005576,GO:0005783,GO:0006487,GO:0009134,GO:0014066,GO:0016020,GO:0017110,GO:0034656,GO:0045134,GO:0045821,GO:0046034,GO:0051084" guanosine-diphosphatase activity|protein binding|extracellular region|endoplasmic reticulum|protein N-linked glycosylation|nucleoside diphosphate catabolic process|regulation of phosphatidylinositol 3-kinase signaling|membrane|nucleoside-diphosphatase activity|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|positive regulation of glycolytic process|ATP metabolic process|'de novo' posttranslational protein folding "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism ENTPD6 2498.170103 2359.772626 2636.567579 1.117297298 0.160013119 0.616458751 1 27.28633761 31.8002055 955 ectonucleoside triphosphate diphosphohydrolase 6 "GO:0000139,GO:0004382,GO:0005576,GO:0005615,GO:0005794,GO:0005886,GO:0008894,GO:0009134,GO:0009986,GO:0016020,GO:0016021,GO:0016311,GO:0017110,GO:0017111,GO:0032026,GO:0034656,GO:0036384,GO:0045134,GO:0051592,GO:1990003" "Golgi membrane|guanosine-diphosphatase activity|extracellular region|extracellular space|Golgi apparatus|plasma membrane|guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity|nucleoside diphosphate catabolic process|cell surface|membrane|integral component of membrane|dephosphorylation|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|response to magnesium ion|nucleobase-containing small molecule catabolic process|cytidine-diphosphatase activity|uridine-diphosphatase activity|response to calcium ion|inosine-diphosphatase activity" "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism ENTPD7 1001.886242 1203.737778 800.0347062 0.664625403 -0.589386659 0.094676902 1 6.904311659 4.786446991 57089 ectonucleoside triphosphate diphosphohydrolase 7 "GO:0003924,GO:0004382,GO:0005794,GO:0006254,GO:0006256,GO:0009134,GO:0016020,GO:0016021,GO:0017110,GO:0017111,GO:0030659,GO:0030666,GO:0034656,GO:0043273,GO:0045134,GO:0046039,GO:0046052,GO:0046872,GO:0050776,GO:0072539" GTPase activity|guanosine-diphosphatase activity|Golgi apparatus|CTP catabolic process|UDP catabolic process|nucleoside diphosphate catabolic process|membrane|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|cytoplasmic vesicle membrane|endocytic vesicle membrane|nucleobase-containing small molecule catabolic process|CTPase activity|uridine-diphosphatase activity|GTP metabolic process|UTP catabolic process|metal ion binding|regulation of immune response|T-helper 17 cell differentiation ENTPD8 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.211732473 0.095285426 377841 ectonucleoside triphosphate diphosphohydrolase 8 "GO:0004382,GO:0005524,GO:0005886,GO:0009124,GO:0009133,GO:0009134,GO:0016020,GO:0016021,GO:0017110,GO:0017111,GO:0034656,GO:0045134,GO:0046872,GO:0102485,GO:0102486,GO:0102487,GO:0102488,GO:0102489,GO:0102490,GO:0102491" guanosine-diphosphatase activity|ATP binding|plasma membrane|nucleoside monophosphate biosynthetic process|nucleoside diphosphate biosynthetic process|nucleoside diphosphate catabolic process|membrane|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|metal ion binding|dATP phosphohydrolase activity|dCTP phosphohydrolase activity|dUTP phosphohydrolase activity|dTTP phosphohydrolase activity|GTP phosphohydrolase activity|8-oxo-dGTP phosphohydrolase activity|dGTP phosphohydrolase activity "hsa00230,hsa00240,hsa05169" Purine metabolism|Pyrimidine metabolism|Epstein-Barr virus infection ENTR1 984.3999017 1086.002886 882.7969172 0.812886345 -0.29887444 0.39798109 1 22.2051736 18.82781537 10807 endosome associated trafficking regulator 1 "GO:0005515,GO:0005768,GO:0005769,GO:0005813,GO:0007049,GO:0015031,GO:0030030,GO:0030496,GO:0030904,GO:0032465,GO:0036064,GO:0045724,GO:0051301,GO:0055037,GO:1903566,GO:1990126" "protein binding|endosome|early endosome|centrosome|cell cycle|protein transport|cell projection organization|midbody|retromer complex|regulation of cytokinesis|ciliary basal body|positive regulation of cilium assembly|cell division|recycling endosome|positive regulation of protein localization to cilium|retrograde transport, endosome to plasma membrane" ENY2 1478.940288 1485.895538 1471.985038 0.990638306 -0.013569687 0.969633413 1 26.60140228 27.48752124 56943 ENY2 transcription and export complex 2 subunit "GO:0000124,GO:0003682,GO:0003713,GO:0005515,GO:0005654,GO:0005739,GO:0006357,GO:0006368,GO:0016578,GO:0016973,GO:0030374,GO:0044615,GO:0045893,GO:0061179,GO:0070390,GO:0071819" "SAGA complex|chromatin binding|transcription coactivator activity|protein binding|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|histone deubiquitination|poly(A)+ mRNA export from nucleus|nuclear receptor coactivator activity|nuclear pore nuclear basket|positive regulation of transcription, DNA-templated|negative regulation of insulin secretion involved in cellular response to glucose stimulus|transcription export complex 2|DUBm complex" EOGT 1252.762967 1111.376785 1394.149149 1.254434291 0.327036902 0.33604923 1 10.5664189 13.82584459 285203 EGF domain specific O-linked N-acetylglucosamine transferase "GO:0005788,GO:0006493,GO:0016262,GO:0016757,GO:0018215,GO:0097363,GO:0097370" "endoplasmic reticulum lumen|protein O-linked glycosylation|protein N-acetylglucosaminyltransferase activity|transferase activity, transferring glycosyl groups|protein phosphopantetheinylation|protein O-GlcNAc transferase activity|protein O-GlcNAcylation via threonine" hsa00514 Other types of O-glycan biosynthesis EOLA1 240.6972277 255.768904 225.6255514 0.88214614 -0.180910417 0.7268833 1 1.580694654 1.454468943 91966 endothelium and lymphocyte associated ASCH domain 1 "GO:0005515,GO:0010468,GO:0032675" protein binding|regulation of gene expression|regulation of interleukin-6 production EOLA2 596.3032071 621.1530526 571.4533616 0.919988011 -0.120313034 0.76166569 1 3.763963965 3.611965177 541578 endothelium and lymphocyte associated ASCH domain 2 EP300 4303.418734 4498.284852 4108.552617 0.913359814 -0.130744779 0.682491515 1 25.95082114 24.72344204 2033 E1A binding protein p300 "GO:0000122,GO:0000123,GO:0000977,GO:0000978,GO:0001085,GO:0001102,GO:0001666,GO:0001756,GO:0001966,GO:0002039,GO:0002209,GO:0002223,GO:0003677,GO:0003682,GO:0003684,GO:0003713,GO:0004402,GO:0004468,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005694,GO:0005829,GO:0006110,GO:0006283,GO:0006355,GO:0006473,GO:0006475,GO:0006915,GO:0006977,GO:0006990,GO:0007219,GO:0007221,GO:0007399,GO:0007507,GO:0007519,GO:0007611,GO:0007623,GO:0008013,GO:0008022,GO:0008134,GO:0008270,GO:0009887,GO:0010506,GO:0010742,GO:0010821,GO:0010976,GO:0016032,GO:0016407,GO:0016573,GO:0016579,GO:0016746,GO:0018076,GO:0018215,GO:0018393,GO:0018394,GO:0030183,GO:0030220,GO:0030324,GO:0030511,GO:0031333,GO:0031490,GO:0031648,GO:0032092,GO:0032481,GO:0032993,GO:0033613,GO:0034644,GO:0035257,GO:0035264,GO:0035855,GO:0036268,GO:0042771,GO:0043627,GO:0043923,GO:0043967,GO:0043969,GO:0045444,GO:0045652,GO:0045721,GO:0045747,GO:0045815,GO:0045893,GO:0045944,GO:0048156,GO:0050681,GO:0050821,GO:0051059,GO:0051091,GO:0051726,GO:0060325,GO:0060765,GO:0061418,GO:0061733,GO:0061920,GO:0061921,GO:0090043,GO:0097157,GO:0097677,GO:0140065,GO:0140066,GO:0140067,GO:0140068,GO:0140069,GO:1900034,GO:1901224,GO:1901796,GO:1904837,GO:1905636" "negative regulation of transcription by RNA polymerase II|histone acetyltransferase complex|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|response to hypoxia|somitogenesis|thigmotaxis|p53 binding|behavioral defense response|stimulatory C-type lectin receptor signaling pathway|DNA binding|chromatin binding|damaged DNA binding|transcription coactivator activity|histone acetyltransferase activity|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|protein binding|nucleus|nucleoplasm|transcription regulator complex|chromosome|cytosol|regulation of glycolytic process|transcription-coupled nucleotide-excision repair|regulation of transcription, DNA-templated|protein acetylation|internal protein amino acid acetylation|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|Notch signaling pathway|positive regulation of transcription of Notch receptor target|nervous system development|heart development|skeletal muscle tissue development|learning or memory|circadian rhythm|beta-catenin binding|protein C-terminus binding|transcription factor binding|zinc ion binding|animal organ morphogenesis|regulation of autophagy|macrophage derived foam cell differentiation|regulation of mitochondrion organization|positive regulation of neuron projection development|viral process|acetyltransferase activity|histone acetylation|protein deubiquitination|transferase activity, transferring acyl groups|N-terminal peptidyl-lysine acetylation|protein phosphopantetheinylation|internal peptidyl-lysine acetylation|peptidyl-lysine acetylation|B cell differentiation|platelet formation|lung development|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of protein-containing complex assembly|chromatin DNA binding|protein destabilization|positive regulation of protein binding|positive regulation of type I interferon production|protein-DNA complex|activating transcription factor binding|cellular response to UV|nuclear hormone receptor binding|multicellular organism growth|megakaryocyte development|swimming|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|response to estrogen|positive regulation by host of viral transcription|histone H4 acetylation|histone H2B acetylation|fat cell differentiation|regulation of megakaryocyte differentiation|negative regulation of gluconeogenesis|positive regulation of Notch signaling pathway|positive regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|tau protein binding|androgen receptor binding|protein stabilization|NF-kappaB binding|positive regulation of DNA-binding transcription factor activity|regulation of cell cycle|face morphogenesis|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|peptide-lysine-N-acetyltransferase activity|protein propionyltransferase activity|peptidyl-lysine propionylation|regulation of tubulin deacetylation|pre-mRNA intronic binding|STAT family protein binding|peptide butyryltransferase activity|peptidyl-lysine crotonylation|peptidyl-lysine butyrylation|histone crotonyltransferase activity|histone butyryltransferase activity|regulation of cellular response to heat|positive regulation of NIK/NF-kappaB signaling|regulation of signal transduction by p53 class mediator|beta-catenin-TCF complex assembly|positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding" "hsa04024,hsa04066,hsa04068,hsa04110,hsa04310,hsa04330,hsa04350,hsa04520,hsa04630,hsa04720,hsa04916,hsa04919,hsa04922,hsa04935,hsa05016,hsa05152,hsa05161,hsa05164,hsa05165,hsa05166,hsa05167,hsa05200,hsa05203,hsa05206,hsa05211,hsa05215" "cAMP signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|Wnt signaling pathway|Notch signaling pathway|TGF-beta signaling pathway|Adherens junction|JAK-STAT signaling pathway|Long-term potentiation|Melanogenesis|Thyroid hormone signaling pathway|Glucagon signaling pathway|Growth hormone synthesis, secretion and action|Huntington disease|Tuberculosis|Hepatitis B|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Renal cell carcinoma|Prostate cancer" other EP400 3111.365819 3058.062333 3164.669306 1.034860955 0.049436939 0.877371422 1 12.60314663 13.60432255 57634 E1A binding protein p400 "GO:0000812,GO:0003677,GO:0003682,GO:0004386,GO:0005515,GO:0005524,GO:0005654,GO:0016607,GO:0035267,GO:0043967,GO:0043968,GO:1990405" Swr1 complex|DNA binding|chromatin binding|helicase activity|protein binding|ATP binding|nucleoplasm|nuclear speck|NuA4 histone acetyltransferase complex|histone H4 acetylation|histone H2A acetylation|protein antigen binding EPAS1 1167.714261 1325.532495 1009.896027 0.761879494 -0.392365268 0.253463054 1 12.3203422 9.790953441 2034 endothelial PAS domain protein 1 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0001666,GO:0001892,GO:0001974,GO:0002027,GO:0003677,GO:0005515,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0007005,GO:0007165,GO:0007601,GO:0008134,GO:0016567,GO:0016607,GO:0030218,GO:0030324,GO:0035035,GO:0042415,GO:0043129,GO:0043565,GO:0043619,GO:0043687,GO:0045944,GO:0046982,GO:0048469,GO:0048625,GO:0055072,GO:0061418,GO:0071456,GO:0120162,GO:2000434" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|response to hypoxia|embryonic placenta development|blood vessel remodeling|regulation of heart rate|DNA binding|protein binding|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|mitochondrion organization|signal transduction|visual perception|transcription factor binding|protein ubiquitination|nuclear speck|erythrocyte differentiation|lung development|histone acetyltransferase binding|norepinephrine metabolic process|surfactant homeostasis|sequence-specific DNA binding|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|post-translational protein modification|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|cell maturation|myoblast fate commitment|iron ion homeostasis|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|positive regulation of cold-induced thermogenesis|regulation of protein neddylation" "hsa05200,hsa05211" Pathways in cancer|Renal cell carcinoma other EPB41 765.386656 729.7533413 801.0199707 1.097658517 0.1344293 0.719066295 1 2.313289874 2.648580872 2035 erythrocyte membrane protein band 4.1 "GO:0003779,GO:0005200,GO:0005515,GO:0005516,GO:0005545,GO:0005829,GO:0005856,GO:0005886,GO:0007049,GO:0008022,GO:0008360,GO:0009898,GO:0014069,GO:0014731,GO:0016323,GO:0016604,GO:0030036,GO:0030054,GO:0030507,GO:0030863,GO:0030866,GO:0031032,GO:0032092,GO:0032991,GO:0045171,GO:0047485,GO:0051219,GO:0051301,GO:0051924,GO:0065003,GO:0072686,GO:0099738,GO:1904478,GO:1904778" actin binding|structural constituent of cytoskeleton|protein binding|calmodulin binding|1-phosphatidylinositol binding|cytosol|cytoskeleton|plasma membrane|cell cycle|protein C-terminus binding|regulation of cell shape|cytoplasmic side of plasma membrane|postsynaptic density|spectrin-associated cytoskeleton|basolateral plasma membrane|nuclear body|actin cytoskeleton organization|cell junction|spectrin binding|cortical cytoskeleton|cortical actin cytoskeleton organization|actomyosin structure organization|positive regulation of protein binding|protein-containing complex|intercellular bridge|protein N-terminus binding|phosphoprotein binding|cell division|regulation of calcium ion transport|protein-containing complex assembly|mitotic spindle|cell cortex region|regulation of intestinal absorption|positive regulation of protein localization to cell cortex EPB41L1 1513.75115 1508.224569 1519.27773 1.007328591 0.010534368 0.976831652 1 7.201494647 7.566756051 2036 erythrocyte membrane protein band 4.1 like 1 "GO:0003779,GO:0005198,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0030866,GO:0031032" actin binding|structural molecule activity|protein binding|cytosol|cytoskeleton|plasma membrane|cortical actin cytoskeleton organization|actomyosin structure organization EPB41L2 2294.457901 2376.011922 2212.90388 0.931352178 -0.102601288 0.74921399 1 22.37571993 21.7373642 2037 erythrocyte membrane protein band 4.1 like 2 "GO:0003779,GO:0005198,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007049,GO:0008091,GO:0008180,GO:0030054,GO:0030507,GO:0030866,GO:0031032,GO:0042731,GO:0051301,GO:0070062,GO:0099738,GO:1904778" actin binding|structural molecule activity|protein binding|nucleoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cycle|spectrin|COP9 signalosome|cell junction|spectrin binding|cortical actin cytoskeleton organization|actomyosin structure organization|PH domain binding|cell division|extracellular exosome|cell cortex region|positive regulation of protein localization to cell cortex EPB41L3 81.73636861 131.9442759 31.52846133 0.238952854 -2.065202094 0.005925613 0.301938934 1.254696226 0.312727983 23136 erythrocyte membrane protein band 4.1 like 3 "GO:0001558,GO:0002175,GO:0003779,GO:0005200,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0006915,GO:0008150,GO:0008360,GO:0030054,GO:0030673,GO:0030865,GO:0030866,GO:0030913,GO:0031032,GO:0033270,GO:0043217,GO:0044224,GO:0048812,GO:0071205,GO:0072659,GO:0106006" regulation of cell growth|protein localization to paranode region of axon|actin binding|structural constituent of cytoskeleton|protein binding|cytosol|cytoskeleton|plasma membrane|cell-cell junction|apoptotic process|biological_process|regulation of cell shape|cell junction|axolemma|cortical cytoskeleton organization|cortical actin cytoskeleton organization|paranodal junction assembly|actomyosin structure organization|paranode region of axon|myelin maintenance|juxtaparanode region of axon|neuron projection morphogenesis|protein localization to juxtaparanode region of axon|protein localization to plasma membrane|cytoskeletal protein-membrane anchor activity EPB41L4A 62.71002661 43.64310664 81.77694657 1.873765478 0.905940395 0.25316011 1 0.269163345 0.526074292 64097 erythrocyte membrane protein band 4.1 like 4A "GO:0003674,GO:0005575,GO:0005737,GO:0005856,GO:0008092,GO:0008150,GO:0031032" molecular_function|cellular_component|cytoplasm|cytoskeleton|cytoskeletal protein binding|biological_process|actomyosin structure organization EPB41L4B 173.6898448 187.7668541 159.6128355 0.850058634 -0.234365739 0.683917 1 1.187676878 1.053084241 54566 erythrocyte membrane protein band 4.1 like 4B "GO:0005200,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005923,GO:0008092,GO:0010628,GO:0010837,GO:0031032,GO:0042060,GO:0045177,GO:0045785,GO:0051549" structural constituent of cytoskeleton|cytoplasm|cytosol|cytoskeleton|plasma membrane|bicellular tight junction|cytoskeletal protein binding|positive regulation of gene expression|regulation of keratinocyte proliferation|actomyosin structure organization|wound healing|apical part of cell|positive regulation of cell adhesion|positive regulation of keratinocyte migration hsa04530 Tight junction EPB41L5 440.1699725 421.2067269 459.1332181 1.090042463 0.124384337 0.77235432 1 1.929507488 2.193844364 57669 erythrocyte membrane protein band 4.1 like 5 "GO:0001701,GO:0001837,GO:0001839,GO:0001917,GO:0003383,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0006931,GO:0007398,GO:0007492,GO:0007509,GO:0008092,GO:0009826,GO:0010608,GO:0010634,GO:0019904,GO:0022408,GO:0031032,GO:0032091,GO:0032092,GO:0032525,GO:0032587,GO:0048319,GO:0048339,GO:0048617,GO:0051894,GO:0070201,GO:0070986,GO:0071560" "in utero embryonic development|epithelial to mesenchymal transition|neural plate morphogenesis|photoreceptor inner segment|apical constriction|protein binding|nucleoplasm|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|substrate-dependent cell migration, cell attachment to substrate|ectoderm development|endoderm development|mesoderm migration involved in gastrulation|cytoskeletal protein binding|unidimensional cell growth|posttranscriptional regulation of gene expression|positive regulation of epithelial cell migration|protein domain specific binding|negative regulation of cell-cell adhesion|actomyosin structure organization|negative regulation of protein binding|positive regulation of protein binding|somite rostral/caudal axis specification|ruffle membrane|axial mesoderm morphogenesis|paraxial mesoderm development|embryonic foregut morphogenesis|positive regulation of focal adhesion assembly|regulation of establishment of protein localization|left/right axis specification|cellular response to transforming growth factor beta stimulus" EPC1 495.2084462 445.5656701 544.8512224 1.222830346 0.290224259 0.479837903 1 4.584788568 5.847920364 80314 enhancer of polycomb homolog 1 "GO:0000122,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0031965,GO:0032777,GO:0035267,GO:0035886,GO:0040008,GO:0043231,GO:0043967,GO:0043968,GO:0045814,GO:0045892,GO:0045893,GO:0045944,GO:0070317" "negative regulation of transcription by RNA polymerase II|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex|vascular associated smooth muscle cell differentiation|regulation of growth|intracellular membrane-bounded organelle|histone H4 acetylation|histone H2A acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of G0 to G1 transition" EPC2 507.0140519 478.0442611 535.9838426 1.121201291 0.16504531 0.6880629 1 4.806681633 5.621405014 26122 enhancer of polycomb homolog 2 "GO:0004402,GO:0006281,GO:0006357,GO:0016573,GO:0032777" histone acetyltransferase activity|DNA repair|regulation of transcription by RNA polymerase II|histone acetylation|Piccolo NuA4 histone acetyltransferase complex EPCAM 51.79788915 38.5683268 65.02745149 1.686032475 0.753632325 0.372648372 1 1.262669484 2.220606209 4072 epithelial cell adhesion molecule "GO:0005515,GO:0005886,GO:0005923,GO:0008284,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0023019,GO:0044877,GO:0045944,GO:0048863,GO:0050900,GO:0070062,GO:0098609,GO:0098641,GO:2000048,GO:2000648" protein binding|plasma membrane|bicellular tight junction|positive regulation of cell population proliferation|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|signal transduction involved in regulation of gene expression|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|stem cell differentiation|leukocyte migration|extracellular exosome|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|negative regulation of cell-cell adhesion mediated by cadherin|positive regulation of stem cell proliferation EPG5 1234.998516 1109.346873 1360.650159 1.226532649 0.294585637 0.387293741 1 3.798817147 4.860080161 57724 ectopic P-granules autophagy protein 5 homolog "GO:0005515,GO:0005737,GO:0005764,GO:0006862,GO:0008333,GO:0032456,GO:0034162,GO:0048471,GO:0097352,GO:1990786" protein binding|cytoplasm|lysosome|nucleotide transport|endosome to lysosome transport|endocytic recycling|toll-like receptor 9 signaling pathway|perinuclear region of cytoplasm|autophagosome maturation|cellular response to dsDNA EPHA10 40.10832813 47.70293051 32.51372575 0.681587596 -0.553029014 0.551906477 1 0.346775534 0.246539242 284656 EPH receptor A10 "GO:0004714,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007411,GO:0008150,GO:0018108,GO:0033674,GO:0043005,GO:0043235,GO:0048013" transmembrane receptor protein tyrosine kinase activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|extracellular region|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|biological_process|peptidyl-tyrosine phosphorylation|positive regulation of kinase activity|neuron projection|receptor complex|ephrin receptor signaling pathway EPHA2 4751.241947 4061.853785 5440.630108 1.33944509 0.421635439 0.188585472 1 48.17764985 67.31106393 1969 EPH receptor A2 "GO:0001501,GO:0001570,GO:0001618,GO:0001649,GO:0002043,GO:0004714,GO:0005005,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0005925,GO:0006954,GO:0007155,GO:0007169,GO:0007275,GO:0007411,GO:0008630,GO:0009986,GO:0010591,GO:0014028,GO:0016477,GO:0016525,GO:0018108,GO:0021915,GO:0030027,GO:0030216,GO:0030316,GO:0031256,GO:0031258,GO:0032587,GO:0032682,GO:0033598,GO:0033628,GO:0033674,GO:0036342,GO:0043005,GO:0043235,GO:0043491,GO:0043535,GO:0045296,GO:0045765,GO:0046058,GO:0046718,GO:0046849,GO:0048013,GO:0048320,GO:0048870,GO:0050830,GO:0051898,GO:0060035,GO:0060326,GO:0060444,GO:0070160,GO:0070309,GO:0070372,GO:0070848,GO:0072659,GO:0090630,GO:1901491,GO:1903078,GO:1903348,GO:1904238" skeletal system development|vasculogenesis|virus receptor activity|osteoblast differentiation|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|transmembrane receptor protein tyrosine kinase activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|focal adhesion|inflammatory response|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|intrinsic apoptotic signaling pathway in response to DNA damage|cell surface|regulation of lamellipodium assembly|notochord formation|cell migration|negative regulation of angiogenesis|peptidyl-tyrosine phosphorylation|neural tube development|lamellipodium|keratinocyte differentiation|osteoclast differentiation|leading edge membrane|lamellipodium membrane|ruffle membrane|negative regulation of chemokine production|mammary gland epithelial cell proliferation|regulation of cell adhesion mediated by integrin|positive regulation of kinase activity|post-anal tail morphogenesis|neuron projection|receptor complex|protein kinase B signaling|regulation of blood vessel endothelial cell migration|cadherin binding|regulation of angiogenesis|cAMP metabolic process|viral entry into host cell|bone remodeling|ephrin receptor signaling pathway|axial mesoderm formation|cell motility|defense response to Gram-positive bacterium|negative regulation of protein kinase B signaling|notochord cell development|cell chemotaxis|branching involved in mammary gland duct morphogenesis|tight junction|lens fiber cell morphogenesis|regulation of ERK1 and ERK2 cascade|response to growth factor|protein localization to plasma membrane|activation of GTPase activity|negative regulation of lymphangiogenesis|positive regulation of protein localization to plasma membrane|positive regulation of bicellular tight junction assembly|pericyte cell differentiation "hsa04010,hsa04014,hsa04015,hsa04151,hsa04360" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance EPHA3 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.065754959 0 2042 EPH receptor A3 "GO:0004714,GO:0005003,GO:0005004,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005769,GO:0005829,GO:0005886,GO:0005887,GO:0007155,GO:0007169,GO:0007275,GO:0007411,GO:0010717,GO:0010976,GO:0015629,GO:0016477,GO:0018108,GO:0031965,GO:0032956,GO:0033674,GO:0043005,GO:0043087,GO:0043235,GO:0045806,GO:0048013,GO:0051893,GO:0070507,GO:0071300,GO:0097155,GO:0097156,GO:1903078" transmembrane receptor protein tyrosine kinase activity|ephrin receptor activity|GPI-linked ephrin receptor activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|extracellular region|nucleoplasm|early endosome|cytosol|plasma membrane|integral component of plasma membrane|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|regulation of epithelial to mesenchymal transition|positive regulation of neuron projection development|actin cytoskeleton|cell migration|peptidyl-tyrosine phosphorylation|nuclear membrane|regulation of actin cytoskeleton organization|positive regulation of kinase activity|neuron projection|regulation of GTPase activity|receptor complex|negative regulation of endocytosis|ephrin receptor signaling pathway|regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|cellular response to retinoic acid|fasciculation of sensory neuron axon|fasciculation of motor neuron axon|positive regulation of protein localization to plasma membrane hsa04360 Axon guidance EPHA4 171.9919832 139.0489677 204.9349986 1.473833298 0.559573354 0.324153254 1 1.0617126 1.632192078 2043 EPH receptor A4 "GO:0001540,GO:0004672,GO:0004714,GO:0005004,GO:0005005,GO:0005515,GO:0005524,GO:0005737,GO:0005741,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005912,GO:0007155,GO:0007169,GO:0007275,GO:0007411,GO:0007628,GO:0008045,GO:0008347,GO:0009986,GO:0010977,GO:0016301,GO:0018108,GO:0021957,GO:0030175,GO:0030424,GO:0030425,GO:0031594,GO:0031901,GO:0033674,GO:0034332,GO:0042731,GO:0042802,GO:0043005,GO:0043087,GO:0043197,GO:0043198,GO:0043204,GO:0043235,GO:0043507,GO:0043679,GO:0044295,GO:0046777,GO:0046875,GO:0048013,GO:0048681,GO:0048710,GO:0050770,GO:0050775,GO:0050821,GO:0061001,GO:0061098,GO:0072178,GO:0090102,GO:0097155,GO:0097156,GO:0097161,GO:0097485,GO:0098685,GO:0098839,GO:0098883,GO:0098978,GO:0099055,GO:0099056,GO:0106030,GO:1900272,GO:1902004,GO:1902961,GO:1903051,GO:1904646,GO:1905244,GO:1990782,GO:2001108" amyloid-beta binding|protein kinase activity|transmembrane receptor protein tyrosine kinase activity|GPI-linked ephrin receptor activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|adherens junction|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|adult walking behavior|motor neuron axon guidance|glial cell migration|cell surface|negative regulation of neuron projection development|kinase activity|peptidyl-tyrosine phosphorylation|corticospinal tract morphogenesis|filopodium|axon|dendrite|neuromuscular junction|early endosome membrane|positive regulation of kinase activity|adherens junction organization|PH domain binding|identical protein binding|neuron projection|regulation of GTPase activity|dendritic spine|dendritic shaft|perikaryon|receptor complex|positive regulation of JUN kinase activity|axon terminus|axonal growth cone|protein autophosphorylation|ephrin receptor binding|ephrin receptor signaling pathway|negative regulation of axon regeneration|regulation of astrocyte differentiation|regulation of axonogenesis|positive regulation of dendrite morphogenesis|protein stabilization|regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|nephric duct morphogenesis|cochlea development|fasciculation of sensory neuron axon|fasciculation of motor neuron axon|DH domain binding|neuron projection guidance|Schaffer collateral - CA1 synapse|postsynaptic density membrane|synapse pruning|glutamatergic synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|neuron projection fasciculation|negative regulation of long-term synaptic potentiation|positive regulation of amyloid-beta formation|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of proteolysis involved in cellular protein catabolic process|cellular response to amyloid-beta|regulation of modification of synaptic structure|protein tyrosine kinase binding|positive regulation of Rho guanyl-nucleotide exchange factor activity hsa04360 Axon guidance EPHB1 117.9184848 180.6621624 55.17480733 0.305403227 -1.71121279 0.009080605 0.400907229 1.289444925 0.410763975 2047 EPH receptor B1 "GO:0001525,GO:0004714,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005783,GO:0005829,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007411,GO:0014719,GO:0018108,GO:0021952,GO:0022008,GO:0030010,GO:0030425,GO:0031290,GO:0031589,GO:0031901,GO:0033674,GO:0043005,GO:0043235,GO:0046328,GO:0046777,GO:0048013,GO:0050965,GO:0051965,GO:0060326,GO:0060996,GO:0060997,GO:0061351,GO:0070062,GO:0070372,GO:1901214,GO:1902723,GO:1902725" angiogenesis|transmembrane receptor protein tyrosine kinase activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|extracellular region|endoplasmic reticulum|cytosol|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|skeletal muscle satellite cell activation|peptidyl-tyrosine phosphorylation|central nervous system projection neuron axonogenesis|neurogenesis|establishment of cell polarity|dendrite|retinal ganglion cell axon guidance|cell-substrate adhesion|early endosome membrane|positive regulation of kinase activity|neuron projection|receptor complex|regulation of JNK cascade|protein autophosphorylation|ephrin receptor signaling pathway|detection of temperature stimulus involved in sensory perception of pain|positive regulation of synapse assembly|cell chemotaxis|dendritic spine development|dendritic spine morphogenesis|neural precursor cell proliferation|extracellular exosome|regulation of ERK1 and ERK2 cascade|regulation of neuron death|negative regulation of skeletal muscle satellite cell proliferation|negative regulation of satellite cell differentiation hsa04360 Axon guidance EPHB2 2516.483355 3140.273766 1892.692944 0.602715905 -0.730449959 0.022530495 0.653915053 13.94020405 8.763906037 2048 EPH receptor B2 "GO:0001525,GO:0001540,GO:0001655,GO:0001933,GO:0004713,GO:0004714,GO:0005005,GO:0005102,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007399,GO:0007411,GO:0007413,GO:0007611,GO:0007612,GO:0008046,GO:0010628,GO:0016310,GO:0018108,GO:0021631,GO:0021952,GO:0022038,GO:0030193,GO:0030424,GO:0030425,GO:0031290,GO:0031915,GO:0033674,GO:0042472,GO:0042802,GO:0043005,GO:0043025,GO:0043235,GO:0044877,GO:0046580,GO:0048013,GO:0048168,GO:0048170,GO:0048593,GO:0050771,GO:0050878,GO:0051389,GO:0051965,GO:0060021,GO:0060996,GO:0060997,GO:0070373,GO:0071679,GO:0097104,GO:0098794,GO:0098978,GO:0099055,GO:0099056,GO:0099557,GO:0106028,GO:1900273,GO:1903078,GO:1904782,GO:1904783" "angiogenesis|amyloid-beta binding|urogenital system development|negative regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane-ephrin receptor activity|signaling receptor binding|protein binding|ATP binding|extracellular region|nucleoplasm|cytosol|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|nervous system development|axon guidance|axonal fasciculation|learning or memory|learning|axon guidance receptor activity|positive regulation of gene expression|phosphorylation|peptidyl-tyrosine phosphorylation|optic nerve morphogenesis|central nervous system projection neuron axonogenesis|corpus callosum development|regulation of blood coagulation|axon|dendrite|retinal ganglion cell axon guidance|positive regulation of synaptic plasticity|positive regulation of kinase activity|inner ear morphogenesis|identical protein binding|neuron projection|neuronal cell body|receptor complex|protein-containing complex binding|negative regulation of Ras protein signal transduction|ephrin receptor signaling pathway|regulation of neuronal synaptic plasticity|positive regulation of long-term neuronal synaptic plasticity|camera-type eye morphogenesis|negative regulation of axonogenesis|regulation of body fluid levels|inactivation of MAPKK activity|positive regulation of synapse assembly|roof of mouth development|dendritic spine development|dendritic spine morphogenesis|negative regulation of ERK1 and ERK2 cascade|commissural neuron axon guidance|postsynaptic membrane assembly|postsynapse|glutamatergic synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission|neuron projection retraction|positive regulation of long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|negative regulation of NMDA glutamate receptor activity|positive regulation of NMDA glutamate receptor activity" hsa04360 Axon guidance EPHB3 83.03883753 86.27125731 79.80641774 0.925063807 -0.112375215 0.892133988 1 1.031963825 0.995754077 2049 EPH receptor B3 "GO:0001525,GO:0001655,GO:0004714,GO:0005003,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005829,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007411,GO:0007413,GO:0008046,GO:0016477,GO:0018108,GO:0021952,GO:0022038,GO:0022407,GO:0030425,GO:0031290,GO:0033674,GO:0034446,GO:0043005,GO:0043087,GO:0043235,GO:0046777,GO:0048013,GO:0048538,GO:0048546,GO:0050770,GO:0051965,GO:0060021,GO:0060996,GO:0060997" angiogenesis|urogenital system development|transmembrane receptor protein tyrosine kinase activity|ephrin receptor activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|extracellular region|cytosol|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|axonal fasciculation|axon guidance receptor activity|cell migration|peptidyl-tyrosine phosphorylation|central nervous system projection neuron axonogenesis|corpus callosum development|regulation of cell-cell adhesion|dendrite|retinal ganglion cell axon guidance|positive regulation of kinase activity|substrate adhesion-dependent cell spreading|neuron projection|regulation of GTPase activity|receptor complex|protein autophosphorylation|ephrin receptor signaling pathway|thymus development|digestive tract morphogenesis|regulation of axonogenesis|positive regulation of synapse assembly|roof of mouth development|dendritic spine development|dendritic spine morphogenesis hsa04360 Axon guidance EPHB4 1261.601647 1648.288493 874.9148019 0.530801984 -0.913754332 0.0074501 0.354102287 20.82834265 11.53196142 2050 EPH receptor B4 "GO:0001525,GO:0002042,GO:0003007,GO:0004714,GO:0005003,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005829,GO:0005886,GO:0005887,GO:0007155,GO:0007169,GO:0007275,GO:0007411,GO:0018108,GO:0033674,GO:0043005,GO:0043235,GO:0046777,GO:0048013,GO:0070062" angiogenesis|cell migration involved in sprouting angiogenesis|heart morphogenesis|transmembrane receptor protein tyrosine kinase activity|ephrin receptor activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|extracellular region|cytosol|plasma membrane|integral component of plasma membrane|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|peptidyl-tyrosine phosphorylation|positive regulation of kinase activity|neuron projection|receptor complex|protein autophosphorylation|ephrin receptor signaling pathway|extracellular exosome hsa04360 Axon guidance EPHX1 1080.887029 1013.941012 1147.833045 1.132051107 0.17893909 0.607992637 1 24.5002554 28.93027587 2052 epoxide hydrolase 1 "GO:0004301,GO:0005515,GO:0005789,GO:0006805,GO:0009636,GO:0016021,GO:0019369,GO:0019439,GO:0033961,GO:0097176" epoxide hydrolase activity|protein binding|endoplasmic reticulum membrane|xenobiotic metabolic process|response to toxic substance|integral component of membrane|arachidonic acid metabolic process|aromatic compound catabolic process|cis-stilbene-oxide hydrolase activity|epoxide metabolic process "hsa00980,hsa04976,hsa05204" Metabolism of xenobiotics by cytochrome P450|Bile secretion|Chemical carcinogenesis EPHX2 8.508359524 9.134603715 7.882115332 0.862885307 -0.212759283 0.973293498 1 0.131021086 0.117926171 2053 epoxide hydrolase 2 "GO:0000287,GO:0004301,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0009636,GO:0010628,GO:0015643,GO:0016311,GO:0016787,GO:0016791,GO:0019373,GO:0033885,GO:0042577,GO:0042632,GO:0042759,GO:0042803,GO:0046272,GO:0046839,GO:0052642,GO:0070062,GO:0090181,GO:0097176" magnesium ion binding|epoxide hydrolase activity|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|response to toxic substance|positive regulation of gene expression|toxic substance binding|dephosphorylation|hydrolase activity|phosphatase activity|epoxygenase P450 pathway|10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity|lipid phosphatase activity|cholesterol homeostasis|long-chain fatty acid biosynthetic process|protein homodimerization activity|stilbene catabolic process|phospholipid dephosphorylation|lysophosphatidic acid phosphatase activity|extracellular exosome|regulation of cholesterol metabolic process|epoxide metabolic process "hsa00590,hsa04146" Arachidonic acid metabolism|Peroxisome EPHX4 152.1503612 163.4079109 140.8928116 0.862215365 -0.213879823 0.724091529 1 5.763255027 5.1832186 253152 epoxide hydrolase 4 "GO:0005515,GO:0016021,GO:0016787" protein binding|integral component of membrane|hydrolase activity EPM2A 64.87355053 56.83753423 72.90956682 1.282771461 0.359264162 0.656165371 1 0.467840175 0.625983279 7957 "EPM2A glucan phosphatase, laforin" "GO:0005515,GO:0005634,GO:0016239,GO:0032007" protein binding|nucleus|positive regulation of macroautophagy|negative regulation of TOR signaling EPM2AIP1 1289.293217 1284.934256 1293.652179 1.006784723 0.00975523 0.979553304 1 8.04517086 8.448659717 9852 EPM2A interacting protein 1 "GO:0005515,GO:0005634,GO:0032868,GO:0042802,GO:0045725,GO:0098554,GO:2000467" protein binding|nucleus|response to insulin|identical protein binding|positive regulation of glycogen biosynthetic process|cytoplasmic side of endoplasmic reticulum membrane|positive regulation of glycogen (starch) synthase activity EPN1 2269.409371 2179.110464 2359.708278 1.082876851 0.114869184 0.720382079 1 6.494307259 7.335468082 29924 epsin 1 "GO:0005515,GO:0005543,GO:0005634,GO:0005768,GO:0005829,GO:0005886,GO:0005905,GO:0006897,GO:0030125,GO:0030276,GO:0042059,GO:0043231,GO:0061024,GO:1903671" protein binding|phospholipid binding|nucleus|endosome|cytosol|plasma membrane|clathrin-coated pit|endocytosis|clathrin vesicle coat|clathrin binding|negative regulation of epidermal growth factor receptor signaling pathway|intracellular membrane-bounded organelle|membrane organization|negative regulation of sprouting angiogenesis hsa04144 Endocytosis EPN2 1199.234803 1055.554207 1342.9154 1.272237267 0.347367753 0.310056451 1 11.05689696 14.67294553 22905 epsin 2 "GO:0005515,GO:0005543,GO:0005768,GO:0005829,GO:0005886,GO:0006897,GO:0030125,GO:0030128,GO:0030276,GO:0030948,GO:0043231,GO:0045296,GO:0045747,GO:0061024,GO:1903671" protein binding|phospholipid binding|endosome|cytosol|plasma membrane|endocytosis|clathrin vesicle coat|clathrin coat of endocytic vesicle|clathrin binding|negative regulation of vascular endothelial growth factor receptor signaling pathway|intracellular membrane-bounded organelle|cadherin binding|positive regulation of Notch signaling pathway|membrane organization|negative regulation of sprouting angiogenesis hsa04144 Endocytosis EPOP 552.062064 728.7383853 375.3857427 0.515117291 -0.957027128 0.016974358 0.570200991 11.33887201 6.092449116 100170841 elongin BC and polycomb repressive complex 2 associated protein "GO:0003682,GO:0005694,GO:0006357,GO:0035098,GO:0035616,GO:0048663,GO:0048863,GO:0070449" chromatin binding|chromosome|regulation of transcription by RNA polymerase II|ESC/E(Z) complex|histone H2B conserved C-terminal lysine deubiquitination|neuron fate commitment|stem cell differentiation|elongin complex EPOR 463.0807107 471.9545253 454.206896 0.962395468 -0.055298247 0.899472062 1 9.914073725 9.952258386 2057 erythropoietin receptor "GO:0004900,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007165,GO:0007420,GO:0007507,GO:0014068,GO:0016607,GO:0038162,GO:0042802,GO:0046579,GO:0046697" erythropoietin receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|signal transduction|brain development|heart development|positive regulation of phosphatidylinositol 3-kinase signaling|nuclear speck|erythropoietin-mediated signaling pathway|identical protein binding|positive regulation of Ras protein signal transduction|decidualization "hsa04060,hsa04151,hsa04630,hsa04640,hsa05200" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer EPRS1 3869.68391 4247.590728 3491.777092 0.822060626 -0.2826833 0.374934422 1 44.07405977 37.79225736 2058 glutamyl-prolyl-tRNA synthetase 1 "GO:0004818,GO:0004827,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006418,GO:0006424,GO:0006433,GO:0008270,GO:0016020,GO:0017101,GO:0017148,GO:0032869,GO:0035613,GO:0042802,GO:0042803,GO:0051020,GO:0065003,GO:0071346,GO:0097452,GO:0140212,GO:1990904" glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|tRNA aminoacylation for protein translation|glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|zinc ion binding|membrane|aminoacyl-tRNA synthetase multienzyme complex|negative regulation of translation|cellular response to insulin stimulus|RNA stem-loop binding|identical protein binding|protein homodimerization activity|GTPase binding|protein-containing complex assembly|cellular response to interferon-gamma|GAIT complex|regulation of long-chain fatty acid import into cell|ribonucleoprotein complex "hsa00860,hsa00970" Porphyrin and chlorophyll metabolism|Aminoacyl-tRNA biosynthesis EPS15 1203.876334 1069.763591 1337.989078 1.250733423 0.322774331 0.345312387 1 9.831201591 12.82588338 2060 epidermal growth factor receptor pathway substrate 15 "GO:0001921,GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005905,GO:0006895,GO:0006897,GO:0009925,GO:0016020,GO:0016050,GO:0016197,GO:0016235,GO:0016324,GO:0017124,GO:0019065,GO:0030132,GO:0031593,GO:0031901,GO:0032456,GO:0042059,GO:0042127,GO:0043231,GO:0045296,GO:0046718,GO:0048268,GO:0061024,GO:0098794,GO:0098884,GO:0098978" positive regulation of receptor recycling|calcium ion binding|protein binding|cytoplasm|cytosol|plasma membrane|clathrin-coated pit|Golgi to endosome transport|endocytosis|basal plasma membrane|membrane|vesicle organization|endosomal transport|aggresome|apical plasma membrane|SH3 domain binding|receptor-mediated endocytosis of virus by host cell|clathrin coat of coated pit|polyubiquitin modification-dependent protein binding|early endosome membrane|endocytic recycling|negative regulation of epidermal growth factor receptor signaling pathway|regulation of cell population proliferation|intracellular membrane-bounded organelle|cadherin binding|viral entry into host cell|clathrin coat assembly|membrane organization|postsynapse|postsynaptic neurotransmitter receptor internalization|glutamatergic synapse hsa04144 Endocytosis EPS15L1 863.3514336 1028.150396 698.5524713 0.679426351 -0.557610923 0.123693746 1 6.802376285 4.820798376 58513 epidermal growth factor receptor pathway substrate 15 like 1 "GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006897,GO:0016020,GO:0016197,GO:0030132,GO:0042059,GO:0045296,GO:0061024" calcium ion binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|endocytosis|membrane|endosomal transport|clathrin coat of coated pit|negative regulation of epidermal growth factor receptor signaling pathway|cadherin binding|membrane organization hsa04144 Endocytosis EPS8 716.2503661 637.3923481 795.1083842 1.247439488 0.318969833 0.396580781 1 4.961068672 6.455214171 2059 epidermal growth factor receptor pathway substrate 8 "GO:0003779,GO:0005515,GO:0005886,GO:0005938,GO:0007266,GO:0008360,GO:0010458,GO:0016601,GO:0030426,GO:0030832,GO:0031267,GO:0031982,GO:0032420,GO:0032587,GO:0035023,GO:0035591,GO:0036336,GO:0045202,GO:0050790,GO:0051016,GO:0051017,GO:0051764,GO:0070062,GO:0070358,GO:1900029" actin binding|protein binding|plasma membrane|cell cortex|Rho protein signal transduction|regulation of cell shape|exit from mitosis|Rac protein signal transduction|growth cone|regulation of actin filament length|small GTPase binding|vesicle|stereocilium|ruffle membrane|regulation of Rho protein signal transduction|signaling adaptor activity|dendritic cell migration|synapse|regulation of catalytic activity|barbed-end actin filament capping|actin filament bundle assembly|actin crosslink formation|extracellular exosome|actin polymerization-dependent cell motility|positive regulation of ruffle assembly EPS8L1 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.045737842 54869 EPS8 like 1 "GO:0003779,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0007266,GO:0032587,GO:0032991,GO:0035023,GO:0042608,GO:0045296,GO:0050790,GO:0070062,GO:1900029" actin binding|guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|Rho protein signal transduction|ruffle membrane|protein-containing complex|regulation of Rho protein signal transduction|T cell receptor binding|cadherin binding|regulation of catalytic activity|extracellular exosome|positive regulation of ruffle assembly EPS8L2 3070.253422 2874.355302 3266.151541 1.136307518 0.184353324 0.562486414 1 43.74277523 51.84634471 64787 EPS8 like 2 "GO:0003779,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0007266,GO:0007605,GO:0031982,GO:0032421,GO:0032426,GO:0032587,GO:0032991,GO:0035023,GO:0045296,GO:0050790,GO:0070062,GO:1900029" actin binding|guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|Rho protein signal transduction|sensory perception of sound|vesicle|stereocilium bundle|stereocilium tip|ruffle membrane|protein-containing complex|regulation of Rho protein signal transduction|cadherin binding|regulation of catalytic activity|extracellular exosome|positive regulation of ruffle assembly EPSTI1 36.51144491 37.55337083 35.469519 0.944509593 -0.082362645 0.961392727 1 0.258311253 0.254487015 94240 epithelial stromal interaction 1 ERAL1 1440.493449 1383.384985 1497.601913 1.082563371 0.11445148 0.732552991 1 38.11946093 43.0443356 26284 Era like 12S mitochondrial rRNA chaperone 1 "GO:0000028,GO:0003723,GO:0005515,GO:0005525,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0019843,GO:0043024,GO:0070125,GO:0070126" ribosomal small subunit assembly|RNA binding|protein binding|GTP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|rRNA binding|ribosomal small subunit binding|mitochondrial translational elongation|mitochondrial translational termination ERAP1 2247.348801 2321.2043 2173.493303 0.9363645 -0.094857856 0.767896667 1 11.92179384 11.64400752 51752 endoplasmic reticulum aminopeptidase 1 "GO:0001525,GO:0002250,GO:0002474,GO:0004177,GO:0005138,GO:0005151,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0005829,GO:0005886,GO:0006508,GO:0006509,GO:0007165,GO:0008217,GO:0008235,GO:0008270,GO:0009617,GO:0016020,GO:0016021,GO:0019885,GO:0042277,GO:0043171,GO:0045088,GO:0045444,GO:0070006,GO:0070062" "angiogenesis|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|aminopeptidase activity|interleukin-6 receptor binding|interleukin-1, type II receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|cytosol|plasma membrane|proteolysis|membrane protein ectodomain proteolysis|signal transduction|regulation of blood pressure|metalloexopeptidase activity|zinc ion binding|response to bacterium|membrane|integral component of membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|peptide binding|peptide catabolic process|regulation of innate immune response|fat cell differentiation|metalloaminopeptidase activity|extracellular exosome" ERAP2 142.7755035 162.3929549 123.1580521 0.758395289 -0.398978091 0.511108583 1 1.444945587 1.143044266 64167 endoplasmic reticulum aminopeptidase 2 "GO:0002250,GO:0002474,GO:0004177,GO:0005737,GO:0005788,GO:0005789,GO:0005886,GO:0006508,GO:0007165,GO:0008217,GO:0008237,GO:0008270,GO:0016021,GO:0019885,GO:0042277,GO:0043171,GO:0070006" adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|aminopeptidase activity|cytoplasm|endoplasmic reticulum lumen|endoplasmic reticulum membrane|plasma membrane|proteolysis|signal transduction|regulation of blood pressure|metallopeptidase activity|zinc ion binding|integral component of membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|peptide binding|peptide catabolic process|metalloaminopeptidase activity ERBB2 3526.968016 2877.40017 4176.535862 1.451496356 0.53754095 0.091670959 1 24.2640972 36.73635106 2064 erb-b2 receptor tyrosine kinase 2 "GO:0000165,GO:0001042,GO:0001934,GO:0004713,GO:0004714,GO:0004888,GO:0005515,GO:0005524,GO:0005634,GO:0005769,GO:0005829,GO:0005886,GO:0005887,GO:0006357,GO:0006468,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007275,GO:0007422,GO:0007507,GO:0007528,GO:0008022,GO:0008045,GO:0008284,GO:0009925,GO:0010008,GO:0014065,GO:0016021,GO:0016323,GO:0016324,GO:0018108,GO:0019838,GO:0019903,GO:0030182,GO:0030307,GO:0032886,GO:0033088,GO:0033674,GO:0035556,GO:0038128,GO:0038143,GO:0042060,GO:0042552,GO:0042802,GO:0043125,GO:0043209,GO:0043235,GO:0043406,GO:0043410,GO:0043547,GO:0045727,GO:0045765,GO:0045785,GO:0045943,GO:0046777,GO:0046982,GO:0048471,GO:0048709,GO:0050679,GO:0051897,GO:0070372,GO:0071363,GO:0071364,GO:0090314,GO:1901185,GO:2000145" MAPK cascade|RNA polymerase I core binding|positive regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane signaling receptor activity|protein binding|ATP binding|nucleus|early endosome|cytosol|plasma membrane|integral component of plasma membrane|regulation of transcription by RNA polymerase II|protein phosphorylation|signal transduction|cell surface receptor signaling pathway|enzyme linked receptor protein signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|peripheral nervous system development|heart development|neuromuscular junction development|protein C-terminus binding|motor neuron axon guidance|positive regulation of cell population proliferation|basal plasma membrane|endosome membrane|phosphatidylinositol 3-kinase signaling|integral component of membrane|basolateral plasma membrane|apical plasma membrane|peptidyl-tyrosine phosphorylation|growth factor binding|protein phosphatase binding|neuron differentiation|positive regulation of cell growth|regulation of microtubule-based process|negative regulation of immature T cell proliferation in thymus|positive regulation of kinase activity|intracellular signal transduction|ERBB2 signaling pathway|ERBB3:ERBB2 complex|wound healing|myelination|identical protein binding|ErbB-3 class receptor binding|myelin sheath|receptor complex|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of GTPase activity|positive regulation of translation|regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of transcription by RNA polymerase I|protein autophosphorylation|protein heterodimerization activity|perinuclear region of cytoplasm|oligodendrocyte differentiation|positive regulation of epithelial cell proliferation|positive regulation of protein kinase B signaling|regulation of ERK1 and ERK2 cascade|cellular response to growth factor stimulus|cellular response to epidermal growth factor stimulus|positive regulation of protein targeting to membrane|negative regulation of ERBB signaling pathway|regulation of cell motility "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04020,hsa04066,hsa04151,hsa04510,hsa04520,hsa04530,hsa05200,hsa05205,hsa05206,hsa05212,hsa05213,hsa05215,hsa05219,hsa05223,hsa05224,hsa05226,hsa05230" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Adherens junction|Tight junction|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Pancreatic cancer|Endometrial cancer|Prostate cancer|Bladder cancer|Non-small cell lung cancer|Breast cancer|Gastric cancer|Central carbon metabolism in cancer ERBB3 125.4915605 125.8545401 125.1285809 0.99423176 -0.008345905 1 1 1.123781465 1.165427943 2065 erb-b2 receptor tyrosine kinase 3 "GO:0000165,GO:0003197,GO:0004713,GO:0004714,GO:0004888,GO:0005515,GO:0005524,GO:0005615,GO:0005886,GO:0005887,GO:0007162,GO:0007165,GO:0007169,GO:0007275,GO:0007399,GO:0007422,GO:0007507,GO:0008284,GO:0009925,GO:0009968,GO:0010628,GO:0014037,GO:0014065,GO:0014068,GO:0016323,GO:0016324,GO:0016328,GO:0018108,GO:0019838,GO:0021545,GO:0030296,GO:0031625,GO:0033674,GO:0038128,GO:0038131,GO:0038132,GO:0038143,GO:0042060,GO:0042127,GO:0042802,GO:0043125,GO:0043235,GO:0043524,GO:0046982,GO:0051048,GO:0051402,GO:0051897,GO:0055025,GO:0061098,GO:0070886,GO:0097192,GO:2000145" MAPK cascade|endocardial cushion development|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane signaling receptor activity|protein binding|ATP binding|extracellular space|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|nervous system development|peripheral nervous system development|heart development|positive regulation of cell population proliferation|basal plasma membrane|negative regulation of signal transduction|positive regulation of gene expression|Schwann cell differentiation|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|peptidyl-tyrosine phosphorylation|growth factor binding|cranial nerve development|protein tyrosine kinase activator activity|ubiquitin protein ligase binding|positive regulation of kinase activity|ERBB2 signaling pathway|neuregulin receptor activity|neuregulin binding|ERBB3:ERBB2 complex|wound healing|regulation of cell population proliferation|identical protein binding|ErbB-3 class receptor binding|receptor complex|negative regulation of neuron apoptotic process|protein heterodimerization activity|negative regulation of secretion|neuron apoptotic process|positive regulation of protein kinase B signaling|positive regulation of cardiac muscle tissue development|positive regulation of protein tyrosine kinase activity|positive regulation of calcineurin-NFAT signaling cascade|extrinsic apoptotic signaling pathway in absence of ligand|regulation of cell motility "hsa01521,hsa04010,hsa04012,hsa04020,hsa04151,hsa05205,hsa05206" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Proteoglycans in cancer|MicroRNAs in cancer ERBB4 6.060044258 10.14955968 1.970528833 0.194149194 -2.364762376 0.199637567 1 0.041615883 0.008427731 2066 erb-b2 receptor tyrosine kinase 4 "GO:0000165,GO:0000976,GO:0001755,GO:0001934,GO:0004713,GO:0004714,GO:0005154,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0005887,GO:0007165,GO:0007169,GO:0007275,GO:0007399,GO:0007416,GO:0007507,GO:0007595,GO:0008284,GO:0008285,GO:0009880,GO:0009925,GO:0014068,GO:0016323,GO:0016477,GO:0018108,GO:0021551,GO:0021889,GO:0030334,GO:0033674,GO:0038128,GO:0042531,GO:0042803,GO:0043235,GO:0043653,GO:0045165,GO:0045211,GO:0045893,GO:0046427,GO:0046777,GO:0051897,GO:0060045,GO:0060644,GO:0060749,GO:0061026,GO:0070374,GO:0071364,GO:0098978,GO:0098982,GO:0099056,GO:0099061,GO:2000010,GO:2000145,GO:2001223" "MAPK cascade|transcription regulatory region sequence-specific DNA binding|neural crest cell migration|positive regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|epidermal growth factor receptor binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|plasma membrane|integral component of plasma membrane|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|nervous system development|synapse assembly|heart development|lactation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|embryonic pattern specification|basal plasma membrane|positive regulation of phosphatidylinositol 3-kinase signaling|basolateral plasma membrane|cell migration|peptidyl-tyrosine phosphorylation|central nervous system morphogenesis|olfactory bulb interneuron differentiation|regulation of cell migration|positive regulation of kinase activity|ERBB2 signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|receptor complex|mitochondrial fragmentation involved in apoptotic process|cell fate commitment|postsynaptic membrane|positive regulation of transcription, DNA-templated|positive regulation of receptor signaling pathway via JAK-STAT|protein autophosphorylation|positive regulation of protein kinase B signaling|positive regulation of cardiac muscle cell proliferation|mammary gland epithelial cell differentiation|mammary gland alveolus development|cardiac muscle tissue regeneration|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|glutamatergic synapse|GABA-ergic synapse|integral component of presynaptic membrane|integral component of postsynaptic density membrane|positive regulation of protein localization to cell surface|regulation of cell motility|negative regulation of neuron migration" "hsa04010,hsa04012,hsa04020,hsa04151,hsa05014,hsa05205" MAPK signaling pathway|ErbB signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Amyotrophic lateral sclerosis|Proteoglycans in cancer ERBIN 2651.030339 2605.391971 2696.668708 1.035033783 0.049677858 0.877161931 1 17.82197624 19.24094132 55914 erbb2 interacting protein "GO:0005102,GO:0005176,GO:0005200,GO:0005515,GO:0005604,GO:0005634,GO:0005737,GO:0005886,GO:0006605,GO:0007155,GO:0007165,GO:0007173,GO:0007229,GO:0009925,GO:0016323,GO:0016607,GO:0030054,GO:0030056,GO:0031965,GO:0032088,GO:0032495,GO:0032496,GO:0038128,GO:0045104,GO:0045175,GO:0045197,GO:0046579,GO:0070433,GO:0071356,GO:0071638,GO:0098794,GO:0098978,GO:0099072" signaling receptor binding|ErbB-2 class receptor binding|structural constituent of cytoskeleton|protein binding|basement membrane|nucleus|cytoplasm|plasma membrane|protein targeting|cell adhesion|signal transduction|epidermal growth factor receptor signaling pathway|integrin-mediated signaling pathway|basal plasma membrane|basolateral plasma membrane|nuclear speck|cell junction|hemidesmosome|nuclear membrane|negative regulation of NF-kappaB transcription factor activity|response to muramyl dipeptide|response to lipopolysaccharide|ERBB2 signaling pathway|intermediate filament cytoskeleton organization|basal protein localization|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of Ras protein signal transduction|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to tumor necrosis factor|negative regulation of monocyte chemotactic protein-1 production|postsynapse|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels hsa04621 NOD-like receptor signaling pathway ERC1 2082.060674 2168.960904 1995.160444 0.919869251 -0.120499281 0.708531653 1 14.29410776 13.71510332 23085 ELKS/RAB6-interacting/CAST family member 1 "GO:0000139,GO:0005515,GO:0005737,GO:0005813,GO:0006355,GO:0007252,GO:0007275,GO:0008385,GO:0015031,GO:0030165,GO:0031267,GO:0036064,GO:0042147,GO:0042734,GO:0043066,GO:0043522,GO:0045202,GO:0045296,GO:0051092" "Golgi membrane|protein binding|cytoplasm|centrosome|regulation of transcription, DNA-templated|I-kappaB phosphorylation|multicellular organism development|IkappaB kinase complex|protein transport|PDZ domain binding|small GTPase binding|ciliary basal body|retrograde transport, endosome to Golgi|presynaptic membrane|negative regulation of apoptotic process|leucine zipper domain binding|synapse|cadherin binding|positive regulation of NF-kappaB transcription factor activity" hsa04064 NF-kappa B signaling pathway ERCC1 1548.579579 1498.075009 1599.084148 1.067425955 0.094135997 0.776984078 1 15.93284635 17.73973209 2067 "ERCC excision repair 1, endonuclease non-catalytic subunit" "GO:0000014,GO:0000109,GO:0000110,GO:0000710,GO:0000720,GO:0000781,GO:0001094,GO:0003677,GO:0003684,GO:0003697,GO:0005515,GO:0005654,GO:0005737,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006295,GO:0006296,GO:0006303,GO:0006310,GO:0006312,GO:0006949,GO:0006979,GO:0007283,GO:0007584,GO:0008022,GO:0008283,GO:0008584,GO:0009650,GO:0009744,GO:0010165,GO:0010259,GO:0019904,GO:0032205,GO:0033683,GO:0035166,GO:0035264,GO:0035902,GO:0036297,GO:0045190,GO:0046686,GO:0048477,GO:0048568,GO:0060261,GO:0061819,GO:0070522,GO:0070911,GO:0070914,GO:0090399,GO:0090656,GO:1904431,GO:1905765,GO:1990599,GO:1990841" "single-stranded DNA endodeoxyribonuclease activity|nucleotide-excision repair complex|nucleotide-excision repair factor 1 complex|meiotic mismatch repair|pyrimidine dimer repair by nucleotide-excision repair|chromosome, telomeric region|TFIID-class transcription factor complex binding|DNA binding|damaged DNA binding|single-stranded DNA binding|protein binding|nucleoplasm|cytoplasm|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via nonhomologous end joining|DNA recombination|mitotic recombination|syncytium formation|response to oxidative stress|spermatogenesis|response to nutrient|protein C-terminus binding|cell population proliferation|male gonad development|UV protection|response to sucrose|response to X-ray|multicellular organism aging|protein domain specific binding|negative regulation of telomere maintenance|nucleotide-excision repair, DNA incision|post-embryonic hemopoiesis|multicellular organism growth|response to immobilization stress|interstrand cross-link repair|isotype switching|response to cadmium ion|oogenesis|embryonic organ development|positive regulation of transcription initiation from RNA polymerase II promoter|telomeric DNA-containing double minutes formation|ERCC4-ERCC1 complex|global genome nucleotide-excision repair|UV-damage excision repair|replicative senescence|t-circle formation|positive regulation of t-circle formation|negative regulation of protection from non-homologous end joining at telomere|3' overhang single-stranded DNA endodeoxyribonuclease activity|promoter-specific chromatin binding" "hsa01524,hsa03420,hsa03460" Platinum drug resistance|Nucleotide excision repair|Fanconi anemia pathway ERCC2 1833.998211 1982.209006 1685.787417 0.850458963 -0.233686471 0.471692091 1 22.10301483 19.60743606 2068 "ERCC excision repair 2, TFIIH core complex helicase subunit" "GO:0000439,GO:0000462,GO:0000717,GO:0001666,GO:0001701,GO:0003678,GO:0003684,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0005737,GO:0005819,GO:0005829,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006915,GO:0006979,GO:0007059,GO:0007568,GO:0008022,GO:0008283,GO:0009411,GO:0009650,GO:0009791,GO:0016032,GO:0021510,GO:0030198,GO:0030282,GO:0030674,GO:0032289,GO:0033683,GO:0035264,GO:0035315,GO:0040016,GO:0043139,GO:0043249,GO:0043388,GO:0045951,GO:0046872,GO:0047485,GO:0048568,GO:0048820,GO:0051539,GO:0060218,GO:0070516,GO:0070911,GO:0071817,GO:1901990" "transcription factor TFIIH core complex|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nucleotide-excision repair, DNA duplex unwinding|response to hypoxia|in utero embryonic development|DNA helicase activity|damaged DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|cytoplasm|spindle|cytosol|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|apoptotic process|response to oxidative stress|chromosome segregation|aging|protein C-terminus binding|cell population proliferation|response to UV|UV protection|post-embryonic development|viral process|spinal cord development|extracellular matrix organization|bone mineralization|protein-macromolecule adaptor activity|central nervous system myelin formation|nucleotide-excision repair, DNA incision|multicellular organism growth|hair cell differentiation|embryonic cleavage|5'-3' DNA helicase activity|erythrocyte maturation|positive regulation of DNA binding|positive regulation of mitotic recombination|metal ion binding|protein N-terminus binding|embryonic organ development|hair follicle maturation|4 iron, 4 sulfur cluster binding|hematopoietic stem cell differentiation|CAK-ERCC2 complex|global genome nucleotide-excision repair|MMXD complex|regulation of mitotic cell cycle phase transition" "hsa03022,hsa03420" Basal transcription factors|Nucleotide excision repair ERCC3 1305.389498 1240.276193 1370.502803 1.104998073 0.144043853 0.67094043 1 21.10030694 24.32014854 2071 "ERCC excision repair 3, TFIIH core complex helicase subunit" "GO:0000112,GO:0000439,GO:0000717,GO:0003677,GO:0003684,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0006265,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006915,GO:0006979,GO:0008022,GO:0008104,GO:0008134,GO:0009411,GO:0016032,GO:0016887,GO:0033683,GO:0035315,GO:0043065,GO:0043138,GO:0047485,GO:0048568,GO:0070911,GO:0097550,GO:1901990" "nucleotide-excision repair factor 3 complex|transcription factor TFIIH core complex|nucleotide-excision repair, DNA duplex unwinding|DNA binding|damaged DNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|DNA topological change|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|apoptotic process|response to oxidative stress|protein C-terminus binding|protein localization|transcription factor binding|response to UV|viral process|ATPase activity|nucleotide-excision repair, DNA incision|hair cell differentiation|positive regulation of apoptotic process|3'-5' DNA helicase activity|protein N-terminus binding|embryonic organ development|global genome nucleotide-excision repair|transcription preinitiation complex|regulation of mitotic cell cycle phase transition" "hsa03022,hsa03420" Basal transcription factors|Nucleotide excision repair ERCC4 341.829845 332.9055576 350.7541323 1.053614529 0.075347145 0.874230701 1 2.346297255 2.578580612 2072 "ERCC excision repair 4, endonuclease catalytic subunit" "GO:0000014,GO:0000109,GO:0000110,GO:0000712,GO:0000723,GO:0000724,GO:0000781,GO:0001094,GO:0003677,GO:0003684,GO:0003697,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006295,GO:0006296,GO:0006303,GO:0008022,GO:0009411,GO:0009650,GO:0010506,GO:0010521,GO:0032205,GO:0033683,GO:0034644,GO:0036297,GO:0042802,GO:0047485,GO:0051974,GO:0061819,GO:0070522,GO:0070911,GO:1901255,GO:1904357,GO:1905765,GO:1905768,GO:1990599,GO:1990841" "single-stranded DNA endodeoxyribonuclease activity|nucleotide-excision repair complex|nucleotide-excision repair factor 1 complex|resolution of meiotic recombination intermediates|telomere maintenance|double-strand break repair via homologous recombination|chromosome, telomeric region|TFIID-class transcription factor complex binding|DNA binding|damaged DNA binding|single-stranded DNA binding|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via nonhomologous end joining|protein C-terminus binding|response to UV|UV protection|regulation of autophagy|telomerase inhibitor activity|negative regulation of telomere maintenance|nucleotide-excision repair, DNA incision|cellular response to UV|interstrand cross-link repair|identical protein binding|protein N-terminus binding|negative regulation of telomerase activity|telomeric DNA-containing double minutes formation|ERCC4-ERCC1 complex|global genome nucleotide-excision repair|nucleotide-excision repair involved in interstrand cross-link repair|negative regulation of telomere maintenance via telomere lengthening|negative regulation of protection from non-homologous end joining at telomere|negative regulation of double-stranded telomeric DNA binding|3' overhang single-stranded DNA endodeoxyribonuclease activity|promoter-specific chromatin binding" "hsa03420,hsa03460" Nucleotide excision repair|Fanconi anemia pathway ERCC5 37.3927889 30.44867905 44.33689874 1.456118956 0.542128219 0.569704215 1 0.396635334 0.602426663 2073 "ERCC excision repair 5, endonuclease" "GO:0000109,GO:0000405,GO:0000993,GO:0003690,GO:0003697,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0009411,GO:0009650,GO:0010225,GO:0033683,GO:0042803,GO:0043066,GO:0044877,GO:0046872,GO:0047485" "nucleotide-excision repair complex|bubble DNA binding|RNA polymerase II complex binding|double-stranded DNA binding|single-stranded DNA binding|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to UV|UV protection|response to UV-C|nucleotide-excision repair, DNA incision|protein homodimerization activity|negative regulation of apoptotic process|protein-containing complex binding|metal ion binding|protein N-terminus binding" hsa03420 Nucleotide excision repair ERCC6 266.9876057 234.4548287 299.5203826 1.277518507 0.353344191 0.473475595 1 0.38778322 0.516740073 2074 "ERCC excision repair 6, chromatin remodeling factor" "GO:0000012,GO:0000077,GO:0000303,GO:0003677,GO:0003678,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006283,GO:0006284,GO:0006290,GO:0006362,GO:0006366,GO:0006979,GO:0007256,GO:0007257,GO:0008022,GO:0008023,GO:0008094,GO:0008630,GO:0009411,GO:0009636,GO:0010165,GO:0010224,GO:0010332,GO:0022008,GO:0030182,GO:0030296,GO:0031175,GO:0032508,GO:0032784,GO:0032786,GO:0035264,GO:0043044,GO:0043565,GO:0044877,GO:0045494,GO:0045739,GO:0045815,GO:0047485,GO:0060261,GO:0061098,GO:0090734,GO:0097680,GO:1905168,GO:2001033" "single strand break repair|DNA damage checkpoint|response to superoxide|DNA binding|DNA helicase activity|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|transcription-coupled nucleotide-excision repair|base-excision repair|pyrimidine dimer repair|transcription elongation from RNA polymerase I promoter|transcription by RNA polymerase II|response to oxidative stress|activation of JNKK activity|activation of JUN kinase activity|protein C-terminus binding|transcription elongation factor complex|DNA-dependent ATPase activity|intrinsic apoptotic signaling pathway in response to DNA damage|response to UV|response to toxic substance|response to X-ray|response to UV-B|response to gamma radiation|neurogenesis|neuron differentiation|protein tyrosine kinase activator activity|neuron projection development|DNA duplex unwinding|regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|multicellular organism growth|ATP-dependent chromatin remodeling|sequence-specific DNA binding|protein-containing complex binding|photoreceptor cell maintenance|positive regulation of DNA repair|positive regulation of gene expression, epigenetic|protein N-terminus binding|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of protein tyrosine kinase activity|site of DNA damage|double-strand break repair via classical nonhomologous end joining|positive regulation of double-strand break repair via homologous recombination|negative regulation of double-strand break repair via nonhomologous end joining" hsa03420 Nucleotide excision repair ERCC6L 663.8680485 626.2278325 701.5082646 1.12021253 0.163772471 0.670341431 1 7.314628809 8.546900498 54821 "ERCC excision repair 6 like, spindle assembly checkpoint helicase" "GO:0000777,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005829,GO:0007049,GO:0015616,GO:0016020,GO:0032508,GO:0051301" condensed chromosome kinetochore|DNA binding|DNA helicase activity|protein binding|ATP binding|cytosol|cell cycle|DNA translocase activity|membrane|DNA duplex unwinding|cell division ERCC6L2 697.2522319 753.0973285 641.4071352 0.851692219 -0.231595925 0.541305091 1 2.951460413 2.622017416 375748 ERCC excision repair 6 like 2 "GO:0003677,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005813,GO:0019901,GO:0032991,GO:0034614,GO:0036297" DNA binding|helicase activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|centrosome|protein kinase binding|protein-containing complex|cellular response to reactive oxygen species|interstrand cross-link repair ERCC8 313.9779389 281.1428032 346.8130746 1.233583327 0.302855171 0.51806685 1 1.435372094 1.846923551 1161 "ERCC excision repair 8, CSA ubiquitin ligase complex subunit" "GO:0000012,GO:0000109,GO:0000209,GO:0003678,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006283,GO:0006289,GO:0006974,GO:0006979,GO:0008094,GO:0009411,GO:0010165,GO:0010996,GO:0014070,GO:0016363,GO:0031464,GO:0032508,GO:0032991,GO:0043161,GO:0043204,GO:0043687,GO:0044877,GO:0045739,GO:0051865,GO:0080008,GO:0097680" single strand break repair|nucleotide-excision repair complex|protein polyubiquitination|DNA helicase activity|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|cellular response to DNA damage stimulus|response to oxidative stress|DNA-dependent ATPase activity|response to UV|response to X-ray|response to auditory stimulus|response to organic cyclic compound|nuclear matrix|Cul4A-RING E3 ubiquitin ligase complex|DNA duplex unwinding|protein-containing complex|proteasome-mediated ubiquitin-dependent protein catabolic process|perikaryon|post-translational protein modification|protein-containing complex binding|positive regulation of DNA repair|protein autoubiquitination|Cul4-RING E3 ubiquitin ligase complex|double-strand break repair via classical nonhomologous end joining "hsa03420,hsa04120" Nucleotide excision repair|Ubiquitin mediated proteolysis other EREG 778.7565113 801.815215 755.6978075 0.942483746 -0.085460357 0.819858686 1 8.799374216 8.650507489 2069 epiregulin "GO:0000165,GO:0001525,GO:0001550,GO:0001556,GO:0001819,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005887,GO:0007143,GO:0007165,GO:0007173,GO:0007267,GO:0008083,GO:0008284,GO:0008285,GO:0009299,GO:0009653,GO:0009887,GO:0019221,GO:0030216,GO:0030665,GO:0030728,GO:0032755,GO:0038128,GO:0042059,GO:0042060,GO:0042327,GO:0042700,GO:0043434,GO:0043616,GO:0045089,GO:0045740,GO:0045741,GO:0045840,GO:0045860,GO:0045892,GO:0048146,GO:0048160,GO:0048661,GO:0050680,GO:0051151,GO:0051781,GO:0051897,GO:0061024,GO:2000145" "MAPK cascade|angiogenesis|ovarian cumulus expansion|oocyte maturation|positive regulation of cytokine production|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|integral component of plasma membrane|female meiotic nuclear division|signal transduction|epidermal growth factor receptor signaling pathway|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|mRNA transcription|anatomical structure morphogenesis|animal organ morphogenesis|cytokine-mediated signaling pathway|keratinocyte differentiation|clathrin-coated vesicle membrane|ovulation|positive regulation of interleukin-6 production|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|wound healing|positive regulation of phosphorylation|luteinizing hormone signaling pathway|response to peptide hormone|keratinocyte proliferation|positive regulation of innate immune response|positive regulation of DNA replication|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitotic nuclear division|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of fibroblast proliferation|primary follicle stage|positive regulation of smooth muscle cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|positive regulation of cell division|positive regulation of protein kinase B signaling|membrane organization|regulation of cell motility" "hsa04010,hsa04012,hsa04151,hsa05210" MAPK signaling pathway|ErbB signaling pathway|PI3K-Akt signaling pathway|Colorectal cancer ERF 1422.002793 1500.104921 1343.900664 0.895871112 -0.158636906 0.635534461 1 24.38222792 22.78425587 2077 ETS2 repressor factor "GO:0000122,GO:0000785,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0030154,GO:0043565" "negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|cell differentiation|sequence-specific DNA binding" ETS ERFE 178.1411021 155.2882632 200.993941 1.294327961 0.372203218 0.509171023 1 2.676013169 3.612838175 151176 erythroferrone "GO:0005179,GO:0005576,GO:0005615,GO:0006879,GO:0007165,GO:0019217,GO:0045721,GO:0046326,GO:0046628,GO:2000193" hormone activity|extracellular region|extracellular space|cellular iron ion homeostasis|signal transduction|regulation of fatty acid metabolic process|negative regulation of gluconeogenesis|positive regulation of glucose import|positive regulation of insulin receptor signaling pathway|positive regulation of fatty acid transport ERG 4.493072978 4.059823873 4.926322083 1.213432463 0.279093814 1 1 0.032845968 0.041573214 2078 ETS transcription factor ERG "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0006468,GO:0007165,GO:0007275,GO:0030154,GO:0045944,GO:1990837,GO:1990904" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|chromatin binding|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|protein phosphorylation|signal transduction|multicellular organism development|cell differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding|ribonucleoprotein complex" "hsa05202,hsa05215" Transcriptional misregulation in cancer|Prostate cancer ETS ERG28 725.6225023 671.9008511 779.3441535 1.15990946 0.214012196 0.569360558 1 14.66784818 17.7462431 11161 ergosterol biosynthesis 28 homolog "GO:0003674,GO:0005515,GO:0005783,GO:0005789,GO:0008150,GO:0016021,GO:0016126,GO:0030133,GO:0030674,GO:0042802" molecular_function|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|biological_process|integral component of membrane|sterol biosynthetic process|transport vesicle|protein-macromolecule adaptor activity|identical protein binding ERGIC1 5697.747524 6329.265419 5066.22963 0.800445122 -0.321125599 0.32085779 1 74.39196221 62.11171288 57222 endoplasmic reticulum-golgi intermediate compartment 1 "GO:0005515,GO:0005654,GO:0005783,GO:0005793,GO:0006888,GO:0006890,GO:0016020,GO:0030134,GO:0030173,GO:0030176,GO:0033116,GO:0043231" "protein binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|membrane|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|intracellular membrane-bounded organelle" ERGIC2 1138.192947 1058.599075 1217.786819 1.150375858 0.202105304 0.558711779 1 8.946155287 10.7347546 51290 ERGIC and golgi 2 "GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0006888,GO:0006890,GO:0016020,GO:0016021,GO:0030134,GO:0033116,GO:0043231" "protein binding|nucleus|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|membrane|integral component of membrane|COPII-coated ER to Golgi transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|intracellular membrane-bounded organelle" ERGIC3 7851.009755 7472.105839 8229.913671 1.101418241 0.139362407 0.67303833 1 287.3468495 330.1221268 51614 ERGIC and golgi 3 "GO:0005515,GO:0005783,GO:0006888,GO:0006890,GO:0016020,GO:0030134,GO:0030173,GO:0030176,GO:0033116" "protein binding|endoplasmic reticulum|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|membrane|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment membrane" ERH 2882.117653 3180.872005 2583.3633 0.812155691 -0.300171776 0.345729747 1 203.6661765 172.5337778 2079 ERH mRNA splicing and mitosis factor "GO:0003723,GO:0005515,GO:0005634,GO:0006139,GO:0006213,GO:0007049,GO:0008327,GO:0030496,GO:0034709" RNA binding|protein binding|nucleus|nucleobase-containing compound metabolic process|pyrimidine nucleoside metabolic process|cell cycle|methyl-CpG binding|midbody|methylosome ERI1 436.1371186 448.610538 423.6636991 0.944390876 -0.082543991 0.85020627 1 2.697760763 2.657486986 90459 exoribonuclease 1 "GO:0000175,GO:0000467,GO:0000738,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008408,GO:0019843,GO:0031047,GO:0031125,GO:0043022,GO:0046872,GO:0071044,GO:0071204,GO:0071207" "3'-5'-exoribonuclease activity|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA catabolic process, exonucleolytic|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|3'-5' exonuclease activity|rRNA binding|gene silencing by RNA|rRNA 3'-end processing|ribosome binding|metal ion binding|histone mRNA catabolic process|histone pre-mRNA 3'end processing complex|histone pre-mRNA stem-loop binding" ERI2 201.2475569 185.7369422 216.7581716 1.167017014 0.222825594 0.684130747 1 2.236547999 2.722521639 112479 ERI1 exoribonuclease family member 2 "GO:0000175,GO:0000467,GO:0000738,GO:0003676,GO:0008270" "3'-5'-exoribonuclease activity|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA catabolic process, exonucleolytic|nucleic acid binding|zinc ion binding" ERI3 1277.395816 1279.859476 1274.932155 0.996150108 -0.00556494 0.989510885 1 37.08259004 38.53104396 79033 ERI1 exoribonuclease family member 3 "GO:0000175,GO:0000467,GO:0000738,GO:0003723,GO:0046872" "3'-5'-exoribonuclease activity|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA catabolic process, exonucleolytic|RNA binding|metal ion binding" ERICH1 361.1018842 336.9653815 385.2383869 1.143258056 0.193151085 0.668943702 1 0.578120184 0.689411196 157697 glutamate rich 1 GO:0005515 protein binding ERICH2 37.09315178 43.64310664 30.54319691 0.699840118 -0.514902726 0.591267843 1 0.714405103 0.521506004 285141 glutamate rich 2 GO:0005515 protein binding ERICH3 4.567301858 9.134603715 0 0 #NAME? 0.049060223 1 0.048473958 0 127254 glutamate rich 3 ERICH5 74.51835383 42.62815067 106.408557 2.496203924 1.319735798 0.079909288 1 1.436437424 3.740095596 203111 glutamate rich 5 GO:0005515 protein binding ERICH6 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.096478865 0.039076324 131831 glutamate rich 6 ERLEC1 1071.111335 985.5222453 1156.700425 1.173692862 0.231054926 0.507785979 1 7.792853241 9.540406744 27248 endoplasmic reticulum lectin 1 "GO:0005515,GO:0005788,GO:0036503,GO:0044322,GO:0051082,GO:0055085,GO:1904153" "protein binding|endoplasmic reticulum lumen|ERAD pathway|endoplasmic reticulum quality control compartment|unfolded protein binding|transmembrane transport|negative regulation of retrograde protein transport, ER to cytosol" hsa04141 Protein processing in endoplasmic reticulum ERLIN1 3781.814752 3898.445875 3665.18363 0.940165324 -0.089013624 0.780337245 1 56.62246362 55.52760223 10613 ER lipid raft associated 1 "GO:0005515,GO:0005783,GO:0005789,GO:0008203,GO:0015485,GO:0016021,GO:0030433,GO:0031625,GO:0032933,GO:0032991,GO:0045541,GO:0045717,GO:0055085" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol metabolic process|cholesterol binding|integral component of membrane|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|SREBP signaling pathway|protein-containing complex|negative regulation of cholesterol biosynthetic process|negative regulation of fatty acid biosynthetic process|transmembrane transport ERLIN2 473.1600008 622.1680086 324.151993 0.521003955 -0.940633771 0.023876957 0.684653464 10.75080681 5.842490399 11160 ER lipid raft associated 2 "GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0008203,GO:0015485,GO:0016021,GO:0030433,GO:0031625,GO:0032933,GO:0032991,GO:0045121,GO:0045541,GO:0045717,GO:0055085" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|cholesterol metabolic process|cholesterol binding|integral component of membrane|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|SREBP signaling pathway|protein-containing complex|membrane raft|negative regulation of cholesterol biosynthetic process|negative regulation of fatty acid biosynthetic process|transmembrane transport ERMAP 292.441177 223.290313 361.5920409 1.619380778 0.695442258 0.145109741 1 2.988601119 5.04815713 114625 erythroblast membrane associated protein (Scianna blood group) "GO:0001817,GO:0005102,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0009897,GO:0016021,GO:0050852" regulation of cytokine production|signaling receptor binding|protein binding|Golgi apparatus|cytosol|plasma membrane|external side of plasma membrane|integral component of membrane|T cell receptor signaling pathway other ERMARD 244.4101555 307.5316584 181.2886526 0.589495903 -0.762446309 0.131612472 1 4.542255349 2.792982829 55780 ER membrane associated RNA degradation "GO:0003674,GO:0005789,GO:0007275,GO:0008150,GO:0016021" molecular_function|endoplasmic reticulum membrane|multicellular organism development|biological_process|integral component of membrane ERMP1 1075.500242 1352.936306 798.0641774 0.589875646 -0.761517249 0.029199443 0.762561169 12.42456047 7.644646891 79956 endoplasmic reticulum metallopeptidase 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006508,GO:0008237,GO:0016020,GO:0016021,GO:0030968,GO:0034599,GO:0046872" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|proteolysis|metallopeptidase activity|membrane|integral component of membrane|endoplasmic reticulum unfolded protein response|cellular response to oxidative stress|metal ion binding ERN1 386.1882704 435.4161104 336.9604305 0.773881403 -0.369815604 0.399405783 1 2.023702848 1.633567495 2081 endoplasmic reticulum to nucleus signaling 1 "GO:0000287,GO:0001935,GO:0004521,GO:0004674,GO:0005161,GO:0005515,GO:0005524,GO:0005637,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0006379,GO:0006402,GO:0006468,GO:0007050,GO:0007257,GO:0016241,GO:0019899,GO:0030176,GO:0030544,GO:0033120,GO:0034620,GO:0034976,GO:0035924,GO:0036289,GO:0036498,GO:0042802,GO:0042803,GO:0043531,GO:0046777,GO:0051082,GO:0051879,GO:0070054,GO:0070059,GO:0070301,GO:0071333,GO:0090502,GO:0098787,GO:0106310,GO:0106311,GO:1900103,GO:1901142,GO:1904707,GO:1990332,GO:1990579,GO:1990597,GO:1990604,GO:1990630" "magnesium ion binding|endothelial cell proliferation|endoribonuclease activity|protein serine/threonine kinase activity|platelet-derived growth factor receptor binding|protein binding|ATP binding|nuclear inner membrane|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|mRNA cleavage|mRNA catabolic process|protein phosphorylation|cell cycle arrest|activation of JUN kinase activity|regulation of macroautophagy|enzyme binding|integral component of endoplasmic reticulum membrane|Hsp70 protein binding|positive regulation of RNA splicing|cellular response to unfolded protein|response to endoplasmic reticulum stress|cellular response to vascular endothelial growth factor stimulus|peptidyl-serine autophosphorylation|IRE1-mediated unfolded protein response|identical protein binding|protein homodimerization activity|ADP binding|protein autophosphorylation|unfolded protein binding|Hsp90 protein binding|mRNA splicing, via endonucleolytic cleavage and ligation|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to hydrogen peroxide|cellular response to glucose stimulus|RNA phosphodiester bond hydrolysis, endonucleolytic|mRNA cleavage involved in mRNA processing|protein serine kinase activity|protein threonine kinase activity|positive regulation of endoplasmic reticulum unfolded protein response|insulin metabolic process|positive regulation of vascular associated smooth muscle cell proliferation|Ire1 complex|peptidyl-serine trans-autophosphorylation|AIP1-IRE1 complex|IRE1-TRAF2-ASK1 complex|IRE1-RACK1-PP2A complex" "hsa04140,hsa04141,hsa04210,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ERO1A 2435.941576 2820.562636 2051.320515 0.727273519 -0.459430047 0.150464624 1 26.13456772 19.82572262 30001 endoplasmic reticulum oxidoreductase 1 alpha "GO:0003756,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0006457,GO:0006464,GO:0009266,GO:0010260,GO:0015035,GO:0016020,GO:0016491,GO:0016671,GO:0018215,GO:0018401,GO:0022417,GO:0030198,GO:0030425,GO:0030968,GO:0034599,GO:0034975,GO:0034976,GO:0043231,GO:0045454,GO:0050873,GO:0051085,GO:0051209,GO:0055114,GO:0070059,GO:0071456" "protein disulfide isomerase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein folding|cellular protein modification process|response to temperature stimulus|animal organ senescence|protein disulfide oxidoreductase activity|membrane|oxidoreductase activity|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|protein phosphopantetheinylation|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|protein maturation by protein folding|extracellular matrix organization|dendrite|endoplasmic reticulum unfolded protein response|cellular response to oxidative stress|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|intracellular membrane-bounded organelle|cell redox homeostasis|brown fat cell differentiation|chaperone cofactor-dependent protein refolding|release of sequestered calcium ion into cytosol|oxidation-reduction process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to hypoxia" "hsa04141,hsa05110" Protein processing in endoplasmic reticulum|Vibrio cholerae infection ERO1B 309.9829414 210.0958855 409.8699973 1.950871129 0.964118479 0.040348726 0.926926504 1.373869003 2.7956953 56605 endoplasmic reticulum oxidoreductase 1 beta "GO:0003756,GO:0005515,GO:0005783,GO:0005789,GO:0006457,GO:0015035,GO:0016491,GO:0016671,GO:0016972,GO:0018215,GO:0034975,GO:0051082,GO:0055114" "protein disulfide isomerase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|protein disulfide oxidoreductase activity|oxidoreductase activity|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|thiol oxidase activity|protein phosphopantetheinylation|protein folding in endoplasmic reticulum|unfolded protein binding|oxidation-reduction process" hsa04141 Protein processing in endoplasmic reticulum ERP29 3319.635674 3353.41452 3285.856829 0.979854059 -0.029361207 0.927380724 1 99.37894399 101.5714619 10961 endoplasmic reticulum protein 29 "GO:0000187,GO:0001934,GO:0003756,GO:0005515,GO:0005783,GO:0005788,GO:0005790,GO:0006457,GO:0006886,GO:0009306,GO:0009986,GO:0010628,GO:0010629,GO:0016020,GO:0018215,GO:0030133,GO:0042470,GO:0042803,GO:0043335,GO:0050709,GO:0051087,GO:1902235" activation of MAPK activity|positive regulation of protein phosphorylation|protein disulfide isomerase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|smooth endoplasmic reticulum|protein folding|intracellular protein transport|protein secretion|cell surface|positive regulation of gene expression|negative regulation of gene expression|membrane|protein phosphopantetheinylation|transport vesicle|melanosome|protein homodimerization activity|protein unfolding|negative regulation of protein secretion|chaperone binding|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum ERP44 1930.784976 1896.952705 1964.617247 1.035670126 0.050564559 0.877079202 1 19.98210534 21.5863206 23071 endoplasmic reticulum protein 44 "GO:0003756,GO:0005515,GO:0005576,GO:0005788,GO:0005789,GO:0005793,GO:0006457,GO:0006986,GO:0009100,GO:0009986,GO:0018215,GO:0034976,GO:0035580,GO:0043312,GO:0045454,GO:0070062" protein disulfide isomerase activity|protein binding|extracellular region|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|protein folding|response to unfolded protein|glycoprotein metabolic process|cell surface|protein phosphopantetheinylation|response to endoplasmic reticulum stress|specific granule lumen|neutrophil degranulation|cell redox homeostasis|extracellular exosome ERRFI1 4429.225769 5150.901539 3707.549999 0.719786618 -0.474358814 0.138227333 1 38.30763461 28.76106968 54206 ERBB receptor feedback inhibitor 1 "GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007175,GO:0017124,GO:0019901,GO:0031234,GO:0031267,GO:0031953,GO:0032691,GO:0032869,GO:0032966,GO:0036120,GO:0042059,GO:0043547,GO:0043589,GO:0045616,GO:0048286,GO:0060426,GO:0060428,GO:0061469,GO:0070373,GO:0071364,GO:0071474,GO:0071549,GO:1903243" GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|negative regulation of epidermal growth factor-activated receptor activity|SH3 domain binding|protein kinase binding|extrinsic component of cytoplasmic side of plasma membrane|small GTPase binding|negative regulation of protein autophosphorylation|negative regulation of interleukin-1 beta production|cellular response to insulin stimulus|negative regulation of collagen biosynthetic process|cellular response to platelet-derived growth factor stimulus|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of GTPase activity|skin morphogenesis|regulation of keratinocyte differentiation|lung alveolus development|lung vasculature development|lung epithelium development|regulation of type B pancreatic cell proliferation|negative regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|cellular hyperosmotic response|cellular response to dexamethasone stimulus|negative regulation of cardiac muscle hypertrophy in response to stress ERV3-1 69.44085238 65.97213794 72.90956682 1.105156951 0.144251271 0.867543423 1 1.042188413 1.201395856 2086 "endogenous retrovirus group 3 member 1, envelope" "GO:0003674,GO:0008150" molecular_function|biological_process ERVMER34-1 9.015837508 10.14955968 7.882115332 0.776596776 -0.364762376 0.872363928 1 0.13766454 0.11151508 100288413 "endogenous retrovirus group MER34 member 1, envelope" "GO:0005576,GO:0005886,GO:0016021" extracellular region|plasma membrane|integral component of membrane ERVV-2 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.08474108 0 100271846 "endogenous retrovirus group V member 2, envelope" GO:0016021 integral component of membrane ESAM 29.13680756 38.5683268 19.70528833 0.510918932 -0.9688337 0.335051083 1 1.067987803 0.5691598 90952 endothelial cell adhesion molecule "GO:0005515,GO:0005886,GO:0005911,GO:0005912,GO:0005923,GO:0007156,GO:0016021,GO:0030833,GO:0032991,GO:0034613,GO:0035633,GO:0050900,GO:0070830,GO:0098609,GO:0098632,GO:2000249" protein binding|plasma membrane|cell-cell junction|adherens junction|bicellular tight junction|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|regulation of actin filament polymerization|protein-containing complex|cellular protein localization|maintenance of blood-brain barrier|leukocyte migration|bicellular tight junction assembly|cell-cell adhesion|cell-cell adhesion mediator activity|regulation of actin cytoskeleton reorganization "hsa04514,hsa04670" Cell adhesion molecules|Leukocyte transendothelial migration ESCO1 537.8041837 562.2856065 513.322761 0.912921752 -0.131436885 0.74643939 1 6.060392071 5.770988464 114799 establishment of sister chromatid cohesion N-acetyltransferase 1 "GO:0000785,GO:0005654,GO:0005694,GO:0006275,GO:0007062,GO:0008080,GO:0008270,GO:0016407,GO:0018215,GO:0018394,GO:0034421,GO:0061733" chromatin|nucleoplasm|chromosome|regulation of DNA replication|sister chromatid cohesion|N-acetyltransferase activity|zinc ion binding|acetyltransferase activity|protein phosphopantetheinylation|peptidyl-lysine acetylation|post-translational protein acetylation|peptide-lysine-N-acetyltransferase activity ESCO2 375.0737353 349.1448531 401.0026175 1.148527936 0.199785948 0.654307881 1 4.205221189 5.037862813 157570 establishment of sister chromatid cohesion N-acetyltransferase 2 "GO:0000785,GO:0001741,GO:0002244,GO:0004468,GO:0005515,GO:0005654,GO:0005694,GO:0005721,GO:0005794,GO:0006275,GO:0006302,GO:0007062,GO:0010369,GO:0016407,GO:0030054,GO:0034421,GO:0035861,GO:0046872,GO:0071168" "chromatin|XY body|hematopoietic progenitor cell differentiation|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|protein binding|nucleoplasm|chromosome|pericentric heterochromatin|Golgi apparatus|regulation of DNA replication|double-strand break repair|sister chromatid cohesion|chromocenter|acetyltransferase activity|cell junction|post-translational protein acetylation|site of double-strand break|metal ion binding|protein localization to chromatin" ESD 1195.250446 1220.99203 1169.508862 0.957834968 -0.062150989 0.858044174 1 21.01221166 20.9931875 2098 esterase D "GO:0005515,GO:0005788,GO:0005829,GO:0008150,GO:0016788,GO:0018738,GO:0031410,GO:0042802,GO:0046294,GO:0047374,GO:0052689,GO:0070062,GO:1901687" "protein binding|endoplasmic reticulum lumen|cytosol|biological_process|hydrolase activity, acting on ester bonds|S-formylglutathione hydrolase activity|cytoplasmic vesicle|identical protein binding|formaldehyde catabolic process|methylumbelliferyl-acetate deacetylase activity|carboxylic ester hydrolase activity|extracellular exosome|glutathione derivative biosynthetic process" ESF1 714.2541051 770.35158 658.1566303 0.854358772 -0.227086064 0.5471612 1 8.304723263 7.400846181 51575 ESF1 nucleolar pre-rRNA processing protein homolog "GO:0003723,GO:0005615,GO:0005654,GO:0005730,GO:0006364" RNA binding|extracellular space|nucleoplasm|nucleolus|rRNA processing ESM1 98.32528176 87.28621328 109.3643502 1.252939567 0.32531683 0.640833146 1 2.109131095 2.756446885 11082 endothelial cell specific molecule 1 "GO:0001525,GO:0002040,GO:0005171,GO:0005178,GO:0005515,GO:0005520,GO:0005576,GO:0008284,GO:1902204" angiogenesis|sprouting angiogenesis|hepatocyte growth factor receptor binding|integrin binding|protein binding|insulin-like growth factor binding|extracellular region|positive regulation of cell population proliferation|positive regulation of hepatocyte growth factor receptor signaling pathway ESPL1 1801.039359 1581.301399 2020.777318 1.277920401 0.353797977 0.276480216 1 11.78101461 15.70371584 9700 "extra spindle pole bodies like 1, separase" "GO:0000070,GO:0000212,GO:0000281,GO:0003824,GO:0004197,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0006508,GO:0006915,GO:0008234,GO:0040001,GO:0045143,GO:0045842,GO:0045875,GO:0051307,GO:0072686" mitotic sister chromatid segregation|meiotic spindle organization|mitotic cytokinesis|catalytic activity|cysteine-type endopeptidase activity|protein binding|nucleus|cytoplasm|centrosome|cytosol|proteolysis|apoptotic process|cysteine-type peptidase activity|establishment of mitotic spindle localization|homologous chromosome segregation|positive regulation of mitotic metaphase/anaphase transition|negative regulation of sister chromatid cohesion|meiotic chromosome separation|mitotic spindle "hsa04110,hsa04114,hsa05166" Cell cycle|Oocyte meiosis|Human T-cell leukemia virus 1 infection ESPNL 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.040427793 0.040935638 339768 espin like "GO:0005515,GO:0005737,GO:0007605,GO:0032426,GO:0051015,GO:0051017" protein binding|cytoplasm|sensory perception of sound|stereocilium tip|actin filament binding|actin filament bundle assembly ESR2 11.00121212 11.16451565 10.83790858 0.970745971 -0.042834281 1 1 0.057271684 0.057991117 2100 estrogen receptor 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003677,GO:0003707,GO:0004879,GO:0005496,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006355,GO:0006357,GO:0006367,GO:0007165,GO:0007267,GO:0008270,GO:0019899,GO:0030284,GO:0030308,GO:0030518,GO:0030520,GO:0034056,GO:0042802,GO:0045893,GO:0048019,GO:0051091,GO:0071392,GO:2000272" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|steroid hormone receptor activity|nuclear receptor activity|steroid binding|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|cell-cell signaling|zinc ion binding|enzyme binding|estrogen receptor activity|negative regulation of cell growth|intracellular steroid hormone receptor signaling pathway|intracellular estrogen receptor signaling pathway|estrogen response element binding|identical protein binding|positive regulation of transcription, DNA-templated|receptor antagonist activity|positive regulation of DNA-binding transcription factor activity|cellular response to estradiol stimulus|negative regulation of signaling receptor activity" "hsa01522,hsa04915,hsa04917,hsa04929,hsa05200,hsa05224" Endocrine resistance|Estrogen signaling pathway|Prolactin signaling pathway|GnRH secretion|Pathways in cancer|Breast cancer ThyrH_rcpt ESRP1 122.6748224 68.00204988 177.347595 2.607974249 1.382929625 0.030977386 0.786268719 0.876129211 2.383347613 54845 epithelial splicing regulatory protein 1 "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0008543,GO:0016604,GO:0042669,GO:0043484,GO:1990904" RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|fibroblast growth factor receptor signaling pathway|nuclear body|regulation of inner ear auditory receptor cell fate specification|regulation of RNA splicing|ribonucleoprotein complex ESRP2 4.985705186 4.059823873 5.911586499 1.456118956 0.542128219 0.871693704 1 0.030416532 0.046197926 80004 epithelial splicing regulatory protein 2 "GO:0000380,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0008543,GO:0043484,GO:0050679,GO:0060441,GO:0060445,GO:1990904" "alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|fibroblast growth factor receptor signaling pathway|regulation of RNA splicing|positive regulation of epithelial cell proliferation|epithelial tube branching involved in lung morphogenesis|branching involved in salivary gland morphogenesis|ribonucleoprotein complex" ESRRA 819.348069 781.5160956 857.1800424 1.096816876 0.133322674 0.717453515 1 11.12451749 12.72715217 2101 estrogen related receptor alpha "GO:0000785,GO:0000978,GO:0000981,GO:0001650,GO:0003700,GO:0003707,GO:0004879,GO:0005496,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0006367,GO:0007005,GO:0008270,GO:0015630,GO:0019904,GO:0030522,GO:0043401,GO:0043565,GO:0045171,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|fibrillar center|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|steroid binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|mitochondrion organization|zinc ion binding|microtubule cytoskeleton|protein domain specific binding|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|sequence-specific DNA binding|intercellular bridge|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" Retinoic_acid_rcpt ESRRB 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.03114132 0.03153251 2103 estrogen related receptor beta "GO:0000785,GO:0000793,GO:0000978,GO:0000981,GO:0000987,GO:0000993,GO:0001228,GO:0001892,GO:0003700,GO:0003707,GO:0004879,GO:0005496,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006367,GO:0008134,GO:0008270,GO:0017145,GO:0019827,GO:0030522,GO:0032039,GO:0043401,GO:0043565,GO:0043697,GO:0045494,GO:0045725,GO:0045821,GO:0045893,GO:0045944,GO:0048839,GO:0071931,GO:0090282,GO:1902459,GO:1990837,GO:2000035,GO:2000737" "chromatin|condensed chromosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II complex binding|DNA-binding transcription activator activity, RNA polymerase II-specific|embryonic placenta development|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|steroid binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|zinc ion binding|stem cell division|stem cell population maintenance|intracellular receptor signaling pathway|integrator complex|steroid hormone mediated signaling pathway|sequence-specific DNA binding|cell dedifferentiation|photoreceptor cell maintenance|positive regulation of glycogen biosynthetic process|positive regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|inner ear development|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|positive regulation of transcription involved in G2/M transition of mitotic cell cycle|positive regulation of stem cell population maintenance|sequence-specific double-stranded DNA binding|regulation of stem cell division|negative regulation of stem cell differentiation" hsa04550 Signaling pathways regulating pluripotency of stem cells ESRRG 34.07797542 39.58328277 28.57266808 0.721836747 -0.470255505 0.636416315 1 0.176552499 0.13293177 2104 estrogen related receptor gamma "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003707,GO:0004879,GO:0005496,GO:0005515,GO:0005654,GO:0006355,GO:0006357,GO:0006367,GO:0008270,GO:0043401,GO:0045893,GO:0045944,GO:0048384,GO:0050682,GO:0120162,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|steroid hormone receptor activity|nuclear receptor activity|steroid binding|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|zinc ion binding|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|AF-2 domain binding|positive regulation of cold-induced thermogenesis|sequence-specific double-stranded DNA binding" ESS2 531.2960446 555.1809147 507.4111745 0.913956444 -0.129802682 0.7503147 1 4.346568986 4.143697142 8220 ess-2 splicing factor homolog "GO:0000398,GO:0003674,GO:0005515,GO:0005634,GO:0007399,GO:0071013" "mRNA splicing, via spliceosome|molecular_function|protein binding|nucleus|nervous system development|catalytic step 2 spliceosome" ESYT1 6114.941187 5853.25107 6376.631304 1.089417014 0.123556304 0.703778717 1 70.4148498 80.01554003 23344 extended synaptotagmin 1 "GO:0005509,GO:0005515,GO:0005544,GO:0005783,GO:0005789,GO:0006687,GO:0006869,GO:0008429,GO:0016020,GO:0030176,GO:0031210,GO:0031227,GO:0031234,GO:0035091,GO:0042802,GO:0061817" calcium ion binding|protein binding|calcium-dependent phospholipid binding|endoplasmic reticulum|endoplasmic reticulum membrane|glycosphingolipid metabolic process|lipid transport|phosphatidylethanolamine binding|membrane|integral component of endoplasmic reticulum membrane|phosphatidylcholine binding|intrinsic component of endoplasmic reticulum membrane|extrinsic component of cytoplasmic side of plasma membrane|phosphatidylinositol binding|identical protein binding|endoplasmic reticulum-plasma membrane tethering ESYT2 2971.809128 3149.40837 2794.209885 0.887217394 -0.172640446 0.587712598 1 23.16723653 21.43977433 57488 extended synaptotagmin 2 "GO:0005509,GO:0005515,GO:0005544,GO:0005789,GO:0005887,GO:0006687,GO:0006869,GO:0006897,GO:0008429,GO:0016020,GO:0031210,GO:0031227,GO:0031234,GO:0035091,GO:0042802,GO:0044232,GO:0045296,GO:0061817,GO:0140268" calcium ion binding|protein binding|calcium-dependent phospholipid binding|endoplasmic reticulum membrane|integral component of plasma membrane|glycosphingolipid metabolic process|lipid transport|endocytosis|phosphatidylethanolamine binding|membrane|phosphatidylcholine binding|intrinsic component of endoplasmic reticulum membrane|extrinsic component of cytoplasmic side of plasma membrane|phosphatidylinositol binding|identical protein binding|organelle membrane contact site|cadherin binding|endoplasmic reticulum-plasma membrane tethering|endoplasmic reticulum-plasma membrane contact site ETAA1 443.9153135 441.5058462 446.3247807 1.010914769 0.015661368 0.976293501 1 4.504575659 4.749898803 54465 ETAA1 activator of ATR kinase "GO:0005515,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0031297,GO:0043539,GO:0043596,GO:0071902,GO:2000001" protein binding|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|replication fork processing|protein serine/threonine kinase activator activity|nuclear replication fork|positive regulation of protein serine/threonine kinase activity|regulation of DNA damage checkpoint ETF1 3894.746048 4277.024451 3512.467645 0.821240955 -0.284122519 0.372563419 1 51.8716954 44.43415975 2107 eukaryotic translation termination factor 1 "GO:0000184,GO:0002184,GO:0003723,GO:0003747,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006415,GO:0006449,GO:0006479,GO:0008079,GO:0016149,GO:0018444,GO:0043022,GO:1990825" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translational termination|RNA binding|translation release factor activity|protein binding|nucleus|cytoplasm|cytosol|translational termination|regulation of translational termination|protein methylation|translation termination factor activity|translation release factor activity, codon specific|translation release factor complex|ribosome binding|sequence-specific mRNA binding" hsa03015 mRNA surveillance pathway ETFA 2023.630436 2182.155332 1865.105541 0.854707964 -0.22649653 0.482064459 1 48.28242437 43.04500367 2108 electron transfer flavoprotein subunit alpha "GO:0005515,GO:0005739,GO:0005759,GO:0009055,GO:0016491,GO:0022904,GO:0033539,GO:0050660" protein binding|mitochondrion|mitochondrial matrix|electron transfer activity|oxidoreductase activity|respiratory electron transport chain|fatty acid beta-oxidation using acyl-CoA dehydrogenase|flavin adenine dinucleotide binding ETFB 632.5865222 710.4691779 554.7038665 0.780757116 -0.357054281 0.355645506 1 35.45099259 28.87089721 2109 electron transfer flavoprotein subunit beta "GO:0005515,GO:0005739,GO:0005759,GO:0009055,GO:0022904,GO:0033539" protein binding|mitochondrion|mitochondrial matrix|electron transfer activity|respiratory electron transport chain|fatty acid beta-oxidation using acyl-CoA dehydrogenase ETFBKMT 25.10667524 32.47859099 17.7347595 0.546044608 -0.87290928 0.408830722 1 0.224012809 0.127590079 254013 electron transfer flavoprotein subunit beta lysine methyltransferase "GO:0005737,GO:0005759,GO:0006479,GO:0016279,GO:0018022,GO:0018023,GO:0031072,GO:0032991,GO:1904733,GO:1904736" cytoplasm|mitochondrial matrix|protein methylation|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|peptidyl-lysine trimethylation|heat shock protein binding|protein-containing complex|negative regulation of electron transfer activity|negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase ETFDH 259.7911176 247.6492563 271.932979 1.098056917 0.134952838 0.791250016 1 5.328190814 6.102679347 2110 electron transfer flavoprotein dehydrogenase "GO:0004174,GO:0005515,GO:0005759,GO:0006979,GO:0009055,GO:0016491,GO:0022900,GO:0022904,GO:0031305,GO:0031966,GO:0033539,GO:0043783,GO:0046872,GO:0048038,GO:0048039,GO:0050660,GO:0051539" "electron-transferring-flavoprotein dehydrogenase activity|protein binding|mitochondrial matrix|response to oxidative stress|electron transfer activity|oxidoreductase activity|electron transport chain|respiratory electron transport chain|integral component of mitochondrial inner membrane|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|metal ion binding|quinone binding|ubiquinone binding|flavin adenine dinucleotide binding|4 iron, 4 sulfur cluster binding" ETFRF1 109.9675838 108.6002886 111.3348791 1.025180324 0.035877695 0.971717435 1 2.054621404 2.197090773 144363 electron transfer flavoprotein regulatory factor 1 "GO:0005515,GO:0005739,GO:0022904" protein binding|mitochondrion|respiratory electron transport chain ETHE1 1094.943749 1267.680004 922.2074939 0.727476564 -0.459027323 0.186124912 1 59.44770382 45.10970855 23474 ETHE1 persulfide dioxygenase "GO:0005506,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006749,GO:0016788,GO:0042802,GO:0050313,GO:0070221,GO:0070813" "iron ion binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|glutathione metabolic process|hydrolase activity, acting on ester bonds|identical protein binding|sulfur dioxygenase activity|sulfide oxidation, using sulfide:quinone oxidoreductase|hydrogen sulfide metabolic process" hsa00920 Sulfur metabolism ETNK1 1163.129638 978.4175535 1347.841722 1.37757312 0.462128897 0.178996331 1 4.294055237 6.170185438 55500 ethanolamine kinase 1 "GO:0004305,GO:0005515,GO:0005524,GO:0005829,GO:0006646,GO:0016020,GO:0016310" ethanolamine kinase activity|protein binding|ATP binding|cytosol|phosphatidylethanolamine biosynthetic process|membrane|phosphorylation hsa00564 Glycerophospholipid metabolism ETNK2 825.1733025 741.9328129 908.4137921 1.224388215 0.292061063 0.424305716 1 11.56193218 14.76608921 55224 ethanolamine kinase 2 "GO:0001701,GO:0001890,GO:0004305,GO:0005515,GO:0005524,GO:0005575,GO:0005829,GO:0006646,GO:0008150,GO:0009791,GO:0016310,GO:0035264" in utero embryonic development|placenta development|ethanolamine kinase activity|protein binding|ATP binding|cellular_component|cytosol|phosphatidylethanolamine biosynthetic process|biological_process|post-embryonic development|phosphorylation|multicellular organism growth hsa00564 Glycerophospholipid metabolism ETS1 4653.430086 5188.45491 4118.405261 0.793763333 -0.333219175 0.298132147 1 46.61645156 38.59634456 2113 "ETS proto-oncogene 1, transcription factor" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006955,GO:0007565,GO:0008134,GO:0008284,GO:0008285,GO:0009612,GO:0010595,GO:0010628,GO:0010715,GO:0021854,GO:0021983,GO:0030154,GO:0030578,GO:0032355,GO:0034616,GO:0035035,GO:0042802,GO:0043536,GO:0044849,GO:0045648,GO:0045765,GO:0045766,GO:0045893,GO:0045944,GO:0048870,GO:0050729,GO:0051272,GO:0060055,GO:0070301,GO:0070555,GO:1902895,GO:1904996" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|immune response|female pregnancy|transcription factor binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to mechanical stimulus|positive regulation of endothelial cell migration|positive regulation of gene expression|regulation of extracellular matrix disassembly|hypothalamus development|pituitary gland development|cell differentiation|PML body organization|response to estradiol|response to laminar fluid shear stress|histone acetyltransferase binding|identical protein binding|positive regulation of blood vessel endothelial cell migration|estrous cycle|positive regulation of erythrocyte differentiation|regulation of angiogenesis|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell motility|positive regulation of inflammatory response|positive regulation of cellular component movement|angiogenesis involved in wound healing|cellular response to hydrogen peroxide|response to interleukin-1|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of leukocyte adhesion to vascular endothelial cell" "hsa04014,hsa04218,hsa05166,hsa05200,hsa05211" Ras signaling pathway|Cellular senescence|Human T-cell leukemia virus 1 infection|Pathways in cancer|Renal cell carcinoma ETS ETS2 1534.599563 1586.376179 1482.822947 0.934723407 -0.097388573 0.769670988 1 10.82078883 10.55013386 2114 "ETS proto-oncogene 2, transcription factor" "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001501,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0019904,GO:0030154,GO:0045893,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|protein domain specific binding|cell differentiation|positive regulation of transcription, DNA-templated|sequence-specific double-stranded DNA binding" "hsa04014,hsa05166" Ras signaling pathway|Human T-cell leukemia virus 1 infection ETS ETV1 965.7892414 1026.120484 905.4579988 0.882409047 -0.180480512 0.611927323 1 6.882450348 6.334742544 2115 ETS variant transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0030154,GO:0045944,GO:0048935,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|cell differentiation|positive regulation of transcription by RNA polymerase II|peripheral nervous system neuron development|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer ETS ETV2 6.478447587 5.074779842 7.882115332 1.553193553 0.635237624 0.773446698 1 0.119156095 0.19304465 2116 ETS variant transcription factor 2 "GO:0000978,GO:0000981,GO:0001228,GO:0001824,GO:0001890,GO:0005634,GO:0006357,GO:0007219,GO:0016055,GO:0030154,GO:0030218,GO:0045603,GO:0045944,GO:0048514,GO:0060803,GO:1990837,GO:2000382" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blastocyst development|placenta development|nucleus|regulation of transcription by RNA polymerase II|Notch signaling pathway|Wnt signaling pathway|cell differentiation|erythrocyte differentiation|positive regulation of endothelial cell differentiation|positive regulation of transcription by RNA polymerase II|blood vessel morphogenesis|BMP signaling pathway involved in mesodermal cell fate specification|sequence-specific double-stranded DNA binding|positive regulation of mesoderm development" ETV3 722.807002 782.5310516 663.0829523 0.847356729 -0.238958637 0.525186546 1 6.342204698 5.605604685 2117 ETS variant transcription factor 3 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0005654,GO:0006357,GO:0008150,GO:0008285,GO:0017151,GO:0030154,GO:0043231,GO:0090571,GO:0097011,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|biological_process|negative regulation of cell population proliferation|DEAD/H-box RNA helicase binding|cell differentiation|intracellular membrane-bounded organelle|RNA polymerase II transcription repressor complex|cellular response to granulocyte macrophage colony-stimulating factor stimulus|sequence-specific double-stranded DNA binding" ETV4 1954.462497 1697.006379 2211.918615 1.303423866 0.382306316 0.236441933 1 31.69151417 43.08683445 2118 ETS variant transcription factor 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0006357,GO:0030154,GO:0045618,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|regulation of transcription by RNA polymerase II|cell differentiation|positive regulation of keratinocyte differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer ETS ETV5 2278.191881 1937.550944 2618.832819 1.35162011 0.434689721 0.174538648 1 24.03971583 33.8922112 2119 ETS variant transcription factor 5 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030154,GO:0034599,GO:0045666,GO:0045944,GO:0048133,GO:0060252,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell differentiation|cellular response to oxidative stress|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|male germ-line stem cell asymmetric division|positive regulation of glial cell proliferation|sequence-specific double-stranded DNA binding" "hsa05202,hsa05215" Transcriptional misregulation in cancer|Prostate cancer ETS ETV6 1671.54439 1855.33951 1487.749269 0.801874407 -0.318551802 0.330716464 1 9.714297627 8.125193032 2120 ETS variant transcription factor 6 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005730,GO:0005829,GO:0006357,GO:0007296,GO:0019904,GO:0022008,GO:0030154,GO:0045944,GO:0071425,GO:0097152" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleolus|cytosol|regulation of transcription by RNA polymerase II|vitellogenesis|protein domain specific binding|neurogenesis|cell differentiation|positive regulation of transcription by RNA polymerase II|hematopoietic stem cell proliferation|mesenchymal cell apoptotic process" hsa05202 Transcriptional misregulation in cancer ETS ETV7 4.463381426 2.029911937 6.896850916 3.397610897 1.764520641 0.414871268 1 0.042979882 0.15231925 51513 ETS variant transcription factor 7 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0009887,GO:0030154,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|animal organ morphogenesis|cell differentiation|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer ETS EVA1A 672.8784428 703.3644861 642.3923996 0.913313669 -0.130817669 0.733859865 1 15.95294666 15.19766267 84141 "eva-1 homolog A, regulator of programmed cell death" "GO:0005515,GO:0005765,GO:0005788,GO:0005789,GO:0005886,GO:0006914,GO:0006915,GO:0016021,GO:0043231,GO:0043687,GO:0044267" protein binding|lysosomal membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|plasma membrane|autophagy|apoptotic process|integral component of membrane|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process EVA1B 554.8169434 445.5656701 664.0682168 1.490393586 0.57569337 0.148631064 1 18.16934729 28.24595277 55194 eva-1 homolog B "GO:0005515,GO:0016021" protein binding|integral component of membrane EVA1C 46.84187551 36.53841486 57.14533616 1.563979619 0.645221712 0.462116207 1 0.511764882 0.834867394 59271 eva-1 homolog C "GO:0005576,GO:0008150,GO:0008201,GO:0016021,GO:0030246" extracellular region|biological_process|heparin binding|integral component of membrane|carbohydrate binding EVC 1906.790496 1772.113121 2041.467871 1.151996364 0.204136163 0.528316507 1 9.862777794 11.85130804 2121 EvC ciliary complex subunit 1 "GO:0001501,GO:0003416,GO:0005737,GO:0005929,GO:0007224,GO:0007517,GO:0016021,GO:0036064,GO:0045880,GO:0051216,GO:0060170,GO:0098797" skeletal system development|endochondral bone growth|cytoplasm|cilium|smoothened signaling pathway|muscle organ development|integral component of membrane|ciliary basal body|positive regulation of smoothened signaling pathway|cartilage development|ciliary membrane|plasma membrane protein complex hsa04340 Hedgehog signaling pathway EVC2 5.970969603 4.059823873 7.882115332 1.941491941 0.957165719 0.632358107 1 0.031574901 0.063943076 132884 EvC ciliary complex subunit 2 "GO:0005634,GO:0005737,GO:0005856,GO:0005929,GO:0007224,GO:0016021,GO:0060170,GO:0098797" nucleus|cytoplasm|cytoskeleton|cilium|smoothened signaling pathway|integral component of membrane|ciliary membrane|plasma membrane protein complex hsa04340 Hedgehog signaling pathway EVI2A 14.00154269 14.20938356 13.79370183 0.970745971 -0.042834281 1 1 0.249620239 0.252755911 2123 ecotropic viral integration site 2A "GO:0004888,GO:0005515,GO:0016021" transmembrane signaling receptor activity|protein binding|integral component of membrane EVI2B 14.01638847 15.22433953 12.80843742 0.841313174 -0.249285159 0.896625813 1 0.383611487 0.336639616 2124 ecotropic viral integration site 2B "GO:0005887,GO:0030854,GO:0043066,GO:0045660,GO:0061515,GO:0071157,GO:2000035" integral component of plasma membrane|positive regulation of granulocyte differentiation|negative regulation of apoptotic process|positive regulation of neutrophil differentiation|myeloid cell development|negative regulation of cell cycle arrest|regulation of stem cell division EVI5 761.8667232 691.1850145 832.548432 1.204523267 0.268462262 0.470109805 1 3.987479511 5.009906121 7813 ecotropic viral integration site 5 "GO:0005096,GO:0005515,GO:0005634,GO:0005815,GO:0005819,GO:0005829,GO:0006886,GO:0007049,GO:0031267,GO:0042147,GO:0043547,GO:0051301,GO:0090630,GO:1902017" "GTPase activator activity|protein binding|nucleus|microtubule organizing center|spindle|cytosol|intracellular protein transport|cell cycle|small GTPase binding|retrograde transport, endosome to Golgi|positive regulation of GTPase activity|cell division|activation of GTPase activity|regulation of cilium assembly" EVI5L 436.7539602 389.7430919 483.7648285 1.24124029 0.311782432 0.462565872 1 5.057420618 6.547882367 115704 ecotropic viral integration site 5 like "GO:0005096,GO:0005515,GO:0006886,GO:0031267,GO:0043547,GO:0090630,GO:1902018" GTPase activator activity|protein binding|intracellular protein transport|small GTPase binding|positive regulation of GTPase activity|activation of GTPase activity|negative regulation of cilium assembly EVL 384.8021701 408.0122993 361.5920409 0.886228287 -0.17424972 0.69462861 1 5.439427107 5.028224949 51466 Enah/Vasp-like "GO:0003779,GO:0005515,GO:0005522,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0007015,GO:0007166,GO:0007399,GO:0007411,GO:0008154,GO:0009887,GO:0010633,GO:0016020,GO:0017124,GO:0030027,GO:0030838,GO:0045010,GO:0051289,GO:0051496,GO:1900028" actin binding|protein binding|profilin binding|cytoplasm|cytosol|cytoskeleton|focal adhesion|actin filament organization|cell surface receptor signaling pathway|nervous system development|axon guidance|actin polymerization or depolymerization|animal organ morphogenesis|negative regulation of epithelial cell migration|membrane|SH3 domain binding|lamellipodium|positive regulation of actin filament polymerization|actin nucleation|protein homotetramerization|positive regulation of stress fiber assembly|negative regulation of ruffle assembly hsa04015 Rap1 signaling pathway EVPL 213.9075366 175.5873825 252.2276906 1.436479586 0.522537491 0.322664205 1 1.361016451 2.039288936 2125 envoplakin "GO:0001533,GO:0005198,GO:0005737,GO:0005829,GO:0005882,GO:0008544,GO:0016020,GO:0018149,GO:0019215,GO:0030057,GO:0030216,GO:0042060,GO:0045104,GO:0045111,GO:0045296,GO:0070062,GO:0070268" cornified envelope|structural molecule activity|cytoplasm|cytosol|intermediate filament|epidermis development|membrane|peptide cross-linking|intermediate filament binding|desmosome|keratinocyte differentiation|wound healing|intermediate filament cytoskeleton organization|intermediate filament cytoskeleton|cadherin binding|extracellular exosome|cornification EWSR1 6454.263087 6553.570688 6354.955487 0.96969359 -0.044399148 0.892010035 1 51.18199471 51.76874802 2130 EWS RNA binding protein 1 "GO:0003712,GO:0003723,GO:0005515,GO:0005516,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005886,GO:0006355,GO:0042802,GO:0046872" "transcription coregulator activity|RNA binding|protein binding|calmodulin binding|nucleus|nucleoplasm|nucleolus|cytoplasm|plasma membrane|regulation of transcription, DNA-templated|identical protein binding|metal ion binding" hsa05202 Transcriptional misregulation in cancer other EXD2 711.8854619 709.4542219 714.316702 1.006853832 0.009854258 0.983299877 1 7.285351487 7.651258351 55218 exonuclease 3'-5' domain containing 2 "GO:0000175,GO:0000287,GO:0000724,GO:0000729,GO:0003676,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005759,GO:0006302,GO:0008296,GO:0008310,GO:0008408,GO:0008852,GO:0016021,GO:0030145,GO:0031297,GO:0042803,GO:0045111,GO:0090305,GO:0090503,GO:0090734" "3'-5'-exoribonuclease activity|magnesium ion binding|double-strand break repair via homologous recombination|DNA double-strand break processing|nucleic acid binding|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial matrix|double-strand break repair|3'-5'-exodeoxyribonuclease activity|single-stranded DNA 3'-5' exodeoxyribonuclease activity|3'-5' exonuclease activity|exodeoxyribonuclease I activity|integral component of membrane|manganese ion binding|replication fork processing|protein homodimerization activity|intermediate filament cytoskeleton|nucleic acid phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, exonucleolytic|site of DNA damage" EXD3 37.00407712 37.55337083 36.45478341 0.970745971 -0.042834281 0.996505263 1 0.353982087 0.358428728 54932 exonuclease 3'-5' domain containing 3 "GO:0003676,GO:0005515,GO:0008408,GO:0046872,GO:0090305" nucleic acid binding|protein binding|3'-5' exonuclease activity|metal ion binding|nucleic acid phosphodiester bond hydrolysis EXO1 777.4203914 710.4691779 844.371605 1.188470424 0.249106001 0.501106436 1 9.380280885 11.62840506 9156 exonuclease 1 "GO:0002455,GO:0003677,GO:0003682,GO:0004523,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0008409,GO:0016446,GO:0016604,GO:0017108,GO:0035312,GO:0045145,GO:0045190,GO:0046872,GO:0048256,GO:0051321,GO:0051908,GO:0090502,GO:0090656,GO:1901796" "humoral immune response mediated by circulating immunoglobulin|DNA binding|chromatin binding|RNA-DNA hybrid ribonuclease activity|exonuclease activity|protein binding|nucleus|nucleoplasm|plasma membrane|DNA replication|DNA repair|mismatch repair|DNA recombination|5'-3' exonuclease activity|somatic hypermutation of immunoglobulin genes|nuclear body|5'-flap endonuclease activity|5'-3' exodeoxyribonuclease activity|single-stranded DNA 5'-3' exodeoxyribonuclease activity|isotype switching|metal ion binding|flap endonuclease activity|meiotic cell cycle|double-stranded DNA 5'-3' exodeoxyribonuclease activity|RNA phosphodiester bond hydrolysis, endonucleolytic|t-circle formation|regulation of signal transduction by p53 class mediator" hsa03430 Mismatch repair EXO5 281.5263179 251.7090802 311.3435556 1.236918253 0.306750157 0.527363506 1 5.13005108 6.618790234 64789 exonuclease 5 "GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0008310,GO:0036297,GO:0045145,GO:0046872,GO:0051539,GO:0090305" "DNA binding|nucleus|nucleoplasm|cytosol|single-stranded DNA 3'-5' exodeoxyribonuclease activity|interstrand cross-link repair|single-stranded DNA 5'-3' exodeoxyribonuclease activity|metal ion binding|4 iron, 4 sulfur cluster binding|nucleic acid phosphodiester bond hydrolysis" EXOC1 839.4123776 772.3814919 906.4432632 1.173569373 0.230903126 0.526705392 1 6.606721461 8.087432969 55763 exocyst complex component 1 "GO:0000145,GO:0005515,GO:0005546,GO:0005737,GO:0005829,GO:0005886,GO:0006887,GO:0006893,GO:0015031,GO:0016020,GO:0016032,GO:0016241,GO:0048015,GO:0048471,GO:0050714,GO:0051601,GO:0051607,GO:0090543,GO:0098592" "exocyst|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|plasma membrane|exocytosis|Golgi to plasma membrane transport|protein transport|membrane|viral process|regulation of macroautophagy|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|positive regulation of protein secretion|exocyst localization|defense response to virus|Flemming body|cytoplasmic side of apical plasma membrane" EXOC2 939.0319634 914.4753275 963.5885994 1.053706503 0.075473078 0.83476656 1 4.006830112 4.403890571 55770 exocyst complex component 2 "GO:0000145,GO:0005515,GO:0005829,GO:0005886,GO:0006887,GO:0006893,GO:0015031,GO:0016020,GO:0019901,GO:0031267,GO:0047485,GO:0090543,GO:2000535" exocyst|protein binding|cytosol|plasma membrane|exocytosis|Golgi to plasma membrane transport|protein transport|membrane|protein kinase binding|small GTPase binding|protein N-terminus binding|Flemming body|regulation of entry of bacterium into host cell "hsa04014,hsa05132" Ras signaling pathway|Salmonella infection EXOC3 1297.923065 1268.69496 1327.151169 1.046075858 0.064987475 0.849512427 1 22.93999431 25.03066655 11336 exocyst complex component 3 "GO:0000145,GO:0000149,GO:0005515,GO:0005794,GO:0005829,GO:0006887,GO:0015031,GO:0030426,GO:0030496,GO:0030667,GO:0042734,GO:0045296,GO:0048471,GO:0051601" exocyst|SNARE binding|protein binding|Golgi apparatus|cytosol|exocytosis|protein transport|growth cone|midbody|secretory granule membrane|presynaptic membrane|cadherin binding|perinuclear region of cytoplasm|exocyst localization EXOC3L4 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.025935388 0 91828 exocyst complex component 3 like 4 "GO:0000145,GO:0000149,GO:0006887,GO:0051601" exocyst|SNARE binding|exocytosis|exocyst localization EXOC4 2384.689267 2314.099608 2455.278926 1.061008315 0.085435963 0.790035165 1 13.98746646 15.48010048 60412 exocyst complex component 4 "GO:0000145,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0006612,GO:0006887,GO:0006893,GO:0006904,GO:0007268,GO:0016020,GO:0016241,GO:0030165,GO:0031267,GO:0032584,GO:0035748,GO:0045202,GO:0047485,GO:0048341,GO:0090522,GO:0090543" exocyst|protein binding|cytoplasm|cytosol|plasma membrane|microvillus|protein targeting to membrane|exocytosis|Golgi to plasma membrane transport|vesicle docking involved in exocytosis|chemical synaptic transmission|membrane|regulation of macroautophagy|PDZ domain binding|small GTPase binding|growth cone membrane|myelin sheath abaxonal region|synapse|protein N-terminus binding|paraxial mesoderm formation|vesicle tethering involved in exocytosis|Flemming body hsa05132 Salmonella infection EXOC5 1822.588245 1673.662392 1971.514098 1.177964031 0.236295487 0.467013139 1 7.996707153 9.825601611 10640 exocyst complex component 5 "GO:0000145,GO:0005515,GO:0005737,GO:0005829,GO:0006887,GO:0006892,GO:0006893,GO:0015031,GO:0030496,GO:0031267" exocyst|protein binding|cytoplasm|cytosol|exocytosis|post-Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein transport|midbody|small GTPase binding hsa05132 Salmonella infection EXOC6 593.96005 797.7553911 390.164709 0.489078123 -1.031863163 0.008925907 0.396661435 6.926709455 3.533630521 54536 exocyst complex component 6 "GO:0000145,GO:0005515,GO:0005829,GO:0005886,GO:0006887,GO:0006893,GO:0006904,GO:0015031,GO:0016020,GO:0030426,GO:0048471,GO:0090543" exocyst|protein binding|cytosol|plasma membrane|exocytosis|Golgi to plasma membrane transport|vesicle docking involved in exocytosis|protein transport|membrane|growth cone|perinuclear region of cytoplasm|Flemming body EXOC6B 1022.791563 948.9838304 1096.599296 1.155551086 0.208581041 0.553269599 1 5.194281119 6.260810084 23233 exocyst complex component 6B "GO:0000145,GO:0005515,GO:0006887,GO:0006893,GO:0006904,GO:0015031,GO:0016020" exocyst|protein binding|exocytosis|Golgi to plasma membrane transport|vesicle docking involved in exocytosis|protein transport|membrane EXOC7 3027.710386 2660.199593 3395.221179 1.276303172 0.351971067 0.268751918 1 22.67413746 30.18565149 23265 exocyst complex component 7 "GO:0000145,GO:0005515,GO:0005815,GO:0005829,GO:0005886,GO:0006887,GO:0015031,GO:0016020,GO:0016241,GO:0032584,GO:0034451,GO:0090543,GO:2000535" exocyst|protein binding|microtubule organizing center|cytosol|plasma membrane|exocytosis|protein transport|membrane|regulation of macroautophagy|growth cone membrane|centriolar satellite|Flemming body|regulation of entry of bacterium into host cell "hsa04910,hsa05132" Insulin signaling pathway|Salmonella infection EXOC8 485.0116276 455.7152298 514.3080254 1.128573266 0.174500081 0.674540407 1 4.525562495 5.327436168 149371 exocyst complex component 8 "GO:0000145,GO:0005515,GO:0005770,GO:0005829,GO:0005886,GO:0006887,GO:0006893,GO:0007032,GO:0008104,GO:0015031,GO:0016020,GO:0016241,GO:0022617,GO:0030426,GO:0031252,GO:0031267,GO:0034613,GO:0035091,GO:0048471" exocyst|protein binding|late endosome|cytosol|plasma membrane|exocytosis|Golgi to plasma membrane transport|endosome organization|protein localization|protein transport|membrane|regulation of macroautophagy|extracellular matrix disassembly|growth cone|cell leading edge|small GTPase binding|cellular protein localization|phosphatidylinositol binding|perinuclear region of cytoplasm EXOG 404.4480753 403.9524754 404.9436752 1.002453753 0.003535682 1 1 3.242790905 3.390776951 9941 exo/endonuclease G "GO:0000014,GO:0003676,GO:0004519,GO:0004521,GO:0005634,GO:0005739,GO:0005743,GO:0006309,GO:0008150,GO:0008409,GO:0032991,GO:0046872,GO:0090502" "single-stranded DNA endodeoxyribonuclease activity|nucleic acid binding|endonuclease activity|endoribonuclease activity|nucleus|mitochondrion|mitochondrial inner membrane|apoptotic DNA fragmentation|biological_process|5'-3' exonuclease activity|protein-containing complex|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" EXOSC1 1167.638794 1151.975024 1183.302564 1.027194635 0.038709572 0.912734428 1 45.12256075 48.34620736 51013 exosome component 1 "GO:0000176,GO:0000178,GO:0003723,GO:0004532,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0043488,GO:0043928,GO:0090503" "nuclear exosome (RNase complex)|exosome (RNase complex)|RNA binding|exoribonuclease activity|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation EXOSC10 2659.911327 2437.924236 2881.898418 1.182111559 0.241366192 0.4489351 1 41.78418344 51.52124073 5394 exosome component 10 "GO:0000166,GO:0000175,GO:0000176,GO:0000178,GO:0000184,GO:0000460,GO:0000467,GO:0000956,GO:0003723,GO:0003727,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0009048,GO:0016020,GO:0032211,GO:0035327,GO:0070034,GO:0071028,GO:0071034,GO:0071035,GO:0071036,GO:0071037,GO:0071038,GO:0071039,GO:0071040,GO:0071044,GO:0071048,GO:0071051,GO:1904872" "nucleotide binding|3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|exosome (RNase complex)|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of 5.8S rRNA|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process|RNA binding|single-stranded RNA binding|exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|dosage compensation by inactivation of X chromosome|membrane|negative regulation of telomere maintenance via telomerase|transcriptionally active chromatin|telomerase RNA binding|nuclear mRNA surveillance|CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|histone mRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing|regulation of telomerase RNA localization to Cajal body" hsa03018 RNA degradation EXOSC2 813.606467 894.1762081 733.0367259 0.819790014 -0.286673679 0.43419553 1 22.28684571 19.05755403 23404 exosome component 2 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0003723,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0008312,GO:0030307,GO:0034427,GO:0034475,GO:0043488,GO:0043928,GO:0071034,GO:0071035,GO:0071038,GO:0071049,GO:0071051" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|7S RNA binding|positive regulation of cell growth|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing" hsa03018 RNA degradation EXOSC3 774.2013336 827.1891142 721.2135529 0.871884724 -0.197790692 0.594144286 1 23.10767264 21.01508761 51010 exosome component 3 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0003723,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0034427,GO:0034475,GO:0035327,GO:0043488,GO:0043928,GO:0045006,GO:0045190,GO:0045830,GO:0071034,GO:0071035,GO:0071038,GO:0071049,GO:0071051" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|transcriptionally active chromatin|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|DNA deamination|isotype switching|positive regulation of isotype switching|CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing" hsa03018 RNA degradation EXOSC4 687.3726177 717.5738696 657.1713658 0.915823992 -0.126857735 0.74052253 1 35.9116453 34.30546017 54512 exosome component 4 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000460,GO:0000956,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0016075,GO:0030307,GO:0034427,GO:0034475,GO:0035327,GO:0035925,GO:0043231,GO:0043488,GO:0043928,GO:0045006,GO:0051607,GO:0071028,GO:0071044,GO:0071051,GO:0090503" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|maturation of 5.8S rRNA|nuclear-transcribed mRNA catabolic process|exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|rRNA catabolic process|positive regulation of cell growth|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|transcriptionally active chromatin|mRNA 3'-UTR AU-rich region binding|intracellular membrane-bounded organelle|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|DNA deamination|defense response to virus|nuclear mRNA surveillance|histone mRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation EXOSC5 161.3767612 154.2733072 168.4802152 1.092089217 0.12709072 0.835269248 1 7.82905688 8.918329152 56915 exosome component 5 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0003723,GO:0004532,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0016075,GO:0034427,GO:0034475,GO:0035327,GO:0043488,GO:0043928,GO:0045006,GO:0051607,GO:0071028,GO:0071051,GO:0090503" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|RNA binding|exoribonuclease activity|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|rRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|transcriptionally active chromatin|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|DNA deamination|defense response to virus|nuclear mRNA surveillance|polyadenylation-dependent snoRNA 3'-end processing|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation EXOSC6 536.4895907 573.4501221 499.5290592 0.871094172 -0.199099402 0.622138298 1 5.625261607 5.11121044 118460 exosome component 6 "GO:0000176,GO:0000177,GO:0000178,GO:0003723,GO:0004532,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0016075,GO:0034427,GO:0034475,GO:0043488,GO:0043928,GO:0045006,GO:0045190,GO:0045830,GO:0071028,GO:0071051,GO:0090503" "nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|RNA binding|exoribonuclease activity|nucleoplasm|nucleolus|cytosol|rRNA processing|rRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|DNA deamination|isotype switching|positive regulation of isotype switching|nuclear mRNA surveillance|polyadenylation-dependent snoRNA 3'-end processing|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation EXOSC7 569.1787441 619.1231407 519.2343475 0.838660863 -0.253840562 0.522666861 1 29.77816044 26.04954679 23016 exosome component 7 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0003723,GO:0004532,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0006401,GO:0016075,GO:0034427,GO:0034473,GO:0034475,GO:0034476,GO:0035925,GO:0043488,GO:0043928,GO:0071028,GO:0071035,GO:0071038,GO:0071042" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|exoribonuclease activity|protein binding|nucleoplasm|nucleolus|cytosol|rRNA processing|RNA catabolic process|rRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U1 snRNA 3'-end processing|U4 snRNA 3'-end processing|U5 snRNA 3'-end processing|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process" hsa03018 RNA degradation EXOSC8 638.1796664 587.6595057 688.6998272 1.171936845 0.228894826 0.554064731 1 18.84919622 23.04161807 11340 exosome component 8 "GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0001650,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006364,GO:0008150,GO:0016075,GO:0034427,GO:0034473,GO:0034475,GO:0034476,GO:0035925,GO:0042802,GO:0043231,GO:0043488,GO:0043928,GO:0071028,GO:0071035,GO:0071038,GO:0071042" "nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|fibrillar center|exoribonuclease activity|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|rRNA processing|biological_process|rRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U1 snRNA 3'-end processing|U4 snRNA 3'-end processing|U5 snRNA 3'-end processing|mRNA 3'-UTR AU-rich region binding|identical protein binding|intracellular membrane-bounded organelle|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process" hsa03018 RNA degradation EXOSC9 502.5034115 506.4630282 498.5437948 0.984363649 -0.022736712 0.960851463 1 13.48610183 13.84707142 5393 exosome component 9 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000228,GO:0000467,GO:0000956,GO:0001102,GO:0003723,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006955,GO:0016075,GO:0030307,GO:0034427,GO:0034473,GO:0034475,GO:0034476,GO:0035925,GO:0043488,GO:0043928,GO:0045944,GO:0070062,GO:0071028,GO:0071035,GO:0071038,GO:0071042" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|nuclear chromosome|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process|RNA polymerase II activating transcription factor binding|RNA binding|exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|immune response|rRNA catabolic process|positive regulation of cell growth|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U1 snRNA 3'-end processing|U4 snRNA 3'-end processing|U5 snRNA 3'-end processing|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|positive regulation of transcription by RNA polymerase II|extracellular exosome|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process" hsa03018 RNA degradation EXPH5 147.7842193 66.98709391 228.5813446 3.412319169 1.770752595 0.003746719 0.21983998 0.265799122 0.946060951 23086 exophilin 5 "GO:0003334,GO:0005768,GO:0006886,GO:0031267,GO:0045921,GO:0050714,GO:0071985" keratinocyte development|endosome|intracellular protein transport|small GTPase binding|positive regulation of exocytosis|positive regulation of protein secretion|multivesicular body sorting pathway EXT1 3553.487269 3713.723888 3393.250651 0.913705691 -0.130198554 0.682768518 1 22.81778645 21.74682055 2131 exostosin glycosyltransferase 1 "GO:0000139,GO:0001501,GO:0001503,GO:0001958,GO:0001974,GO:0002062,GO:0002067,GO:0002524,GO:0003128,GO:0003416,GO:0005783,GO:0005789,GO:0005794,GO:0006024,GO:0006486,GO:0007033,GO:0007165,GO:0007369,GO:0007411,GO:0007492,GO:0007498,GO:0008217,GO:0008375,GO:0008543,GO:0009615,GO:0009642,GO:0010467,GO:0014033,GO:0015012,GO:0015014,GO:0015020,GO:0016021,GO:0016757,GO:0017145,GO:0019882,GO:0021554,GO:0021772,GO:0030163,GO:0030176,GO:0030199,GO:0030210,GO:0030509,GO:0032836,GO:0033627,GO:0033692,GO:0035176,GO:0035249,GO:0035988,GO:0036022,GO:0036336,GO:0036339,GO:0042044,GO:0042060,GO:0042311,GO:0042328,GO:0042596,GO:0042803,GO:0045165,GO:0045202,GO:0046872,GO:0046982,GO:0050508,GO:0050509,GO:0050891,GO:0050901,GO:0051923,GO:0055078,GO:0060047,GO:0060070,GO:0060218,GO:0060351,GO:0060441,GO:0060506,GO:0060560,GO:0061744,GO:0061974,GO:0062094,GO:0065003,GO:0070593,GO:0071503,GO:0071625,GO:0071711,GO:0072112,GO:0072498,GO:0097021,GO:0120193,GO:1901706,GO:1904888,GO:1990823" "Golgi membrane|skeletal system development|ossification|endochondral ossification|blood vessel remodeling|chondrocyte differentiation|glandular epithelial cell differentiation|hypersensitivity|heart field specification|endochondral bone growth|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|glycosaminoglycan biosynthetic process|protein glycosylation|vacuole organization|signal transduction|gastrulation|axon guidance|endoderm development|mesoderm development|regulation of blood pressure|acetylglucosaminyltransferase activity|fibroblast growth factor receptor signaling pathway|response to virus|response to light intensity|gene expression|neural crest cell differentiation|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|glucuronosyltransferase activity|integral component of membrane|transferase activity, transferring glycosyl groups|stem cell division|antigen processing and presentation|optic nerve development|olfactory bulb development|protein catabolic process|integral component of endoplasmic reticulum membrane|collagen fibril organization|heparin biosynthetic process|BMP signaling pathway|glomerular basement membrane development|cell adhesion mediated by integrin|cellular polysaccharide biosynthetic process|social behavior|synaptic transmission, glutamatergic|chondrocyte proliferation|limb joint morphogenesis|dendritic cell migration|lymphocyte adhesion to endothelial cell of high endothelial venule|fluid transport|wound healing|vasodilation|heparan sulfate N-acetylglucosaminyltransferase activity|fear response|protein homodimerization activity|cell fate commitment|synapse|metal ion binding|protein heterodimerization activity|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|multicellular organismal water homeostasis|leukocyte tethering or rolling|sulfation|sodium ion homeostasis|heart contraction|canonical Wnt signaling pathway|hematopoietic stem cell differentiation|cartilage development involved in endochondral bone morphogenesis|epithelial tube branching involved in lung morphogenesis|smoothened signaling pathway involved in lung development|developmental growth involved in morphogenesis|motor behavior|perichondral bone morphogenesis|stomach development|protein-containing complex assembly|dendrite self-avoidance|response to heparin|vocalization behavior|basement membrane organization|glomerular visceral epithelial cell differentiation|embryonic skeletal joint development|lymphocyte migration into lymphoid organs|tight junction organization|mesenchymal cell differentiation involved in bone development|cranial skeletal system development|response to leukemia inhibitory factor" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXT2 4010.813016 4095.347332 3926.2787 0.9587169 -0.060823231 0.849278887 1 53.72051149 53.72129238 2132 exostosin glycosyltransferase 2 "GO:0000139,GO:0001503,GO:0001707,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006024,GO:0006487,GO:0007165,GO:0008217,GO:0008375,GO:0010467,GO:0015012,GO:0015014,GO:0015020,GO:0016020,GO:0016021,GO:0016757,GO:0030154,GO:0030210,GO:0033692,GO:0042044,GO:0042311,GO:0042328,GO:0042803,GO:0043541,GO:0044344,GO:0046872,GO:0046982,GO:0050508,GO:0050509,GO:0050891,GO:0051923,GO:0055078,GO:0060047,GO:0060350,GO:0070062" "Golgi membrane|ossification|mesoderm formation|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|glycosaminoglycan biosynthetic process|protein N-linked glycosylation|signal transduction|regulation of blood pressure|acetylglucosaminyltransferase activity|gene expression|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|glucuronosyltransferase activity|membrane|integral component of membrane|transferase activity, transferring glycosyl groups|cell differentiation|heparin biosynthetic process|cellular polysaccharide biosynthetic process|fluid transport|vasodilation|heparan sulfate N-acetylglucosaminyltransferase activity|protein homodimerization activity|UDP-N-acetylglucosamine transferase complex|cellular response to fibroblast growth factor stimulus|metal ion binding|protein heterodimerization activity|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|multicellular organismal water homeostasis|sulfation|sodium ion homeostasis|heart contraction|endochondral bone morphogenesis|extracellular exosome" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXTL2 344.9907575 380.6084881 309.3730268 0.812837959 -0.298960318 0.511065366 1 6.090514129 5.163852892 2135 exostosin like glycosyltransferase 2 "GO:0001888,GO:0005515,GO:0005539,GO:0005576,GO:0005654,GO:0005783,GO:0005789,GO:0005829,GO:0006044,GO:0006486,GO:0015012,GO:0016021,GO:0019276,GO:0030145,GO:0035248,GO:0036498,GO:0047237" "glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding|glycosaminoglycan binding|extracellular region|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|N-acetylglucosamine metabolic process|protein glycosylation|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|UDP-N-acetylgalactosamine metabolic process|manganese ion binding|alpha-1,4-N-acetylgalactosaminyltransferase activity|IRE1-mediated unfolded protein response|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXTL3 1745.76459 1709.185851 1782.34333 1.04280253 0.060465988 0.854344971 1 13.45000524 14.62986974 2137 exostosin like glycosyltransferase 3 "GO:0001888,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006486,GO:0015012,GO:0016021,GO:0016757,GO:0030307,GO:0036498,GO:0046872" "glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein glycosylation|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|transferase activity, transferring glycosyl groups|positive regulation of cell growth|IRE1-mediated unfolded protein response|metal ion binding" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EYA2 56.365191 47.70293051 65.02745149 1.363175193 0.446970986 0.593731602 1 0.973010529 1.383519051 2139 EYA transcriptional coactivator and phosphatase 2 "GO:0000287,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006281,GO:0007501,GO:0008134,GO:0014706,GO:0016576,GO:0030154,GO:0035335,GO:0045739,GO:0048856,GO:0097192,GO:0097345,GO:2001240" magnesium ion binding|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|DNA repair|mesodermal cell fate specification|transcription factor binding|striated muscle tissue development|histone dephosphorylation|cell differentiation|peptidyl-tyrosine dephosphorylation|positive regulation of DNA repair|anatomical structure development|extrinsic apoptotic signaling pathway in absence of ligand|mitochondrial outer membrane permeabilization|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand EYA3 560.3707475 623.1829646 497.5585304 0.798414845 -0.324789549 0.414363215 1 4.818628809 4.012989339 2140 EYA transcriptional coactivator and phosphatase 3 "GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0006302,GO:0007275,GO:0007601,GO:0009653,GO:0010212,GO:0016576,GO:0030154,GO:0035335,GO:0045739,GO:0046872,GO:0048856,GO:2001240" protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|centrosome|double-strand break repair|multicellular organism development|visual perception|anatomical structure morphogenesis|response to ionizing radiation|histone dephosphorylation|cell differentiation|peptidyl-tyrosine dephosphorylation|positive regulation of DNA repair|metal ion binding|anatomical structure development|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand EZH1 780.2250053 733.8131651 826.6368455 1.126494978 0.171840882 0.643333293 1 8.021810506 9.425786283 2145 enhancer of zeste 1 polycomb repressive complex 2 subunit "GO:0000122,GO:0000781,GO:0003677,GO:0003682,GO:0003714,GO:0005654,GO:0006338,GO:0006348,GO:0009653,GO:0018024,GO:0021766,GO:0031493,GO:0031507,GO:0035098,GO:0045944,GO:0070734" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|DNA binding|chromatin binding|transcription corepressor activity|nucleoplasm|chromatin remodeling|chromatin silencing at telomere|anatomical structure morphogenesis|histone-lysine N-methyltransferase activity|hippocampus development|nucleosomal histone binding|heterochromatin assembly|ESC/E(Z) complex|positive regulation of transcription by RNA polymerase II|histone H3-K27 methylation" hsa00310 Lysine degradation chromosome_remodelling_factor EZH2 855.7852851 813.9946866 897.5758835 1.102680273 0.141014536 0.699194846 1 6.638640785 7.635626995 2146 enhancer of zeste 2 polycomb repressive complex 2 subunit "GO:0000122,GO:0000781,GO:0000785,GO:0000978,GO:0000979,GO:0001226,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005677,GO:0005737,GO:0006306,GO:0006325,GO:0006348,GO:0006355,GO:0008284,GO:0010718,GO:0014013,GO:0014834,GO:0014898,GO:0016279,GO:0016571,GO:0018024,GO:0021695,GO:0021766,GO:0030183,GO:0031490,GO:0032355,GO:0034244,GO:0035098,GO:0035984,GO:0036333,GO:0042054,GO:0042752,GO:0043021,GO:0043406,GO:0043433,GO:0043547,GO:0045120,GO:0045605,GO:0045814,GO:0045892,GO:0046976,GO:0048387,GO:0048468,GO:0048511,GO:0051154,GO:0070301,GO:0070314,GO:0070317,GO:0070734,GO:0070878,GO:0071168,GO:0071902,GO:0097421,GO:0098532,GO:1900006,GO:1902808,GO:1904772,GO:1990841,GO:2000134" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II transcription corepressor binding|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|chromatin silencing complex|cytoplasm|DNA methylation|chromatin organization|chromatin silencing at telomere|regulation of transcription, DNA-templated|positive regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|regulation of gliogenesis|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|cardiac muscle hypertrophy in response to stress|protein-lysine N-methyltransferase activity|histone methylation|histone-lysine N-methyltransferase activity|cerebellar cortex development|hippocampus development|B cell differentiation|chromatin DNA binding|response to estradiol|negative regulation of transcription elongation from RNA polymerase II promoter|ESC/E(Z) complex|cellular response to trichostatin A|hepatocyte homeostasis|histone methyltransferase activity|regulation of circadian rhythm|ribonucleoprotein complex binding|positive regulation of MAP kinase activity|negative regulation of DNA-binding transcription factor activity|positive regulation of GTPase activity|pronucleus|negative regulation of epidermal cell differentiation|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K27 specific)|negative regulation of retinoic acid receptor signaling pathway|cell development|rhythmic process|negative regulation of striated muscle cell differentiation|cellular response to hydrogen peroxide|G1 to G0 transition|negative regulation of G0 to G1 transition|histone H3-K27 methylation|primary miRNA binding|protein localization to chromatin|positive regulation of protein serine/threonine kinase activity|liver regeneration|histone H3-K27 trimethylation|positive regulation of dendrite development|positive regulation of cell cycle G1/S phase transition|response to tetrachloromethane|promoter-specific chromatin binding|negative regulation of G1/S transition of mitotic cell cycle" "hsa00310,hsa05206" Lysine degradation|MicroRNAs in cancer chromosome_remodelling_factor EZR 3415.740771 3389.952934 3441.528607 1.015214274 0.021784259 0.94634628 1 54.94053027 58.17903211 7430 ezrin "GO:0000122,GO:0001650,GO:0001726,GO:0001772,GO:0001931,GO:0001951,GO:0003376,GO:0003723,GO:0003779,GO:0005515,GO:0005615,GO:0005737,GO:0005768,GO:0005829,GO:0005884,GO:0005886,GO:0005902,GO:0005903,GO:0005925,GO:0007159,GO:0007411,GO:0008017,GO:0008022,GO:0008360,GO:0008361,GO:0010628,GO:0010737,GO:0015629,GO:0016020,GO:0016323,GO:0016324,GO:0019898,GO:0019904,GO:0022612,GO:0022614,GO:0030033,GO:0030175,GO:0030315,GO:0030863,GO:0030953,GO:0031528,GO:0031532,GO:0031623,GO:0031982,GO:0032532,GO:0032587,GO:0032703,GO:0032956,GO:0032991,GO:0034236,GO:0034237,GO:0034629,GO:0036064,GO:0040018,GO:0042802,GO:0042995,GO:0043622,GO:0044297,GO:0044393,GO:0044548,GO:0044853,GO:0045177,GO:0045198,GO:0045296,GO:0046847,GO:0048015,GO:0048471,GO:0050714,GO:0050839,GO:0050860,GO:0051015,GO:0051017,GO:0051018,GO:0051117,GO:0051286,GO:0051660,GO:0061028,GO:0070062,GO:0070373,GO:0071320,GO:0071944,GO:0072659,GO:0072697,GO:0097449,GO:0097454,GO:0097718,GO:0098592,GO:1901222,GO:1902115,GO:1902896,GO:1902966,GO:1903078,GO:1903364,GO:1903753,GO:2000643" negative regulation of transcription by RNA polymerase II|fibrillar center|ruffle|immunological synapse|uropod|intestinal D-glucose absorption|sphingosine-1-phosphate receptor signaling pathway|RNA binding|actin binding|protein binding|extracellular space|cytoplasm|endosome|cytosol|actin filament|plasma membrane|microvillus|brush border|focal adhesion|leukocyte cell-cell adhesion|axon guidance|microtubule binding|protein C-terminus binding|regulation of cell shape|regulation of cell size|positive regulation of gene expression|protein kinase A signaling|actin cytoskeleton|membrane|basolateral plasma membrane|apical plasma membrane|extrinsic component of membrane|protein domain specific binding|gland morphogenesis|membrane to membrane docking|microvillus assembly|filopodium|T-tubule|cortical cytoskeleton|astral microtubule organization|microvillus membrane|actin cytoskeleton reorganization|receptor internalization|vesicle|regulation of microvillus length|ruffle membrane|negative regulation of interleukin-2 production|regulation of actin cytoskeleton organization|protein-containing complex|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|cellular protein-containing complex localization|ciliary basal body|positive regulation of multicellular organism growth|identical protein binding|cell projection|cortical microtubule organization|cell body|microspike|S100 protein binding|plasma membrane raft|apical part of cell|establishment of epithelial cell apical/basal polarity|cadherin binding|filopodium assembly|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|positive regulation of protein secretion|cell adhesion molecule binding|negative regulation of T cell receptor signaling pathway|actin filament binding|actin filament bundle assembly|protein kinase A binding|ATPase binding|cell tip|establishment of centrosome localization|establishment of endothelial barrier|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|cellular response to cAMP|cell periphery|protein localization to plasma membrane|protein localization to cell cortex|astrocyte projection|Schwann cell microvillus|disordered domain specific binding|cytoplasmic side of apical plasma membrane|regulation of NIK/NF-kappaB signaling|regulation of organelle assembly|terminal web assembly|positive regulation of protein localization to early endosome|positive regulation of protein localization to plasma membrane|positive regulation of cellular protein catabolic process|negative regulation of p38MAPK cascade|positive regulation of early endosome to late endosome transport "hsa04530,hsa04670,hsa04810,hsa04971,hsa05130,hsa05205,hsa05206" Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Gastric acid secretion|Pathogenic Escherichia coli infection|Proteoglycans in cancer|MicroRNAs in cancer F11R 1219.017042 1027.13544 1410.898644 1.373624733 0.457987921 0.179751123 1 11.01435243 15.78130816 50848 F11 receptor "GO:0001618,GO:0001817,GO:0005178,GO:0005515,GO:0005886,GO:0005911,GO:0005923,GO:0006954,GO:0007159,GO:0007179,GO:0008360,GO:0009314,GO:0016021,GO:0030054,GO:0030165,GO:0030198,GO:0031032,GO:0031410,GO:0032956,GO:0032991,GO:0034260,GO:0035025,GO:0035633,GO:0035683,GO:0036057,GO:0042803,GO:0043547,GO:0045296,GO:0045777,GO:0046718,GO:0050892,GO:0050900,GO:0051493,GO:0051497,GO:0070062,GO:0070160,GO:0070830,GO:0071260,GO:0072659,GO:0090557,GO:0090559,GO:0098609,GO:1901731,GO:1902396,GO:1903142,GO:2000249,GO:2000810" virus receptor activity|regulation of cytokine production|integrin binding|protein binding|plasma membrane|cell-cell junction|bicellular tight junction|inflammatory response|leukocyte cell-cell adhesion|transforming growth factor beta receptor signaling pathway|regulation of cell shape|response to radiation|integral component of membrane|cell junction|PDZ domain binding|extracellular matrix organization|actomyosin structure organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|protein-containing complex|negative regulation of GTPase activity|positive regulation of Rho protein signal transduction|maintenance of blood-brain barrier|memory T cell extravasation|slit diaphragm|protein homodimerization activity|positive regulation of GTPase activity|cadherin binding|positive regulation of blood pressure|viral entry into host cell|intestinal absorption|leukocyte migration|regulation of cytoskeleton organization|negative regulation of stress fiber assembly|extracellular exosome|tight junction|bicellular tight junction assembly|cellular response to mechanical stimulus|protein localization to plasma membrane|establishment of endothelial intestinal barrier|regulation of membrane permeability|cell-cell adhesion|positive regulation of platelet aggregation|protein localization to bicellular tight junction|positive regulation of establishment of endothelial barrier|regulation of actin cytoskeleton reorganization|regulation of bicellular tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05120" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Epithelial cell signaling in Helicobacter pylori infection F12 150.0731904 189.7967661 110.3496147 0.581409351 -0.782373819 0.187168885 1 4.353503913 2.640200333 2161 coagulation factor XII "GO:0002353,GO:0002542,GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005791,GO:0005886,GO:0006508,GO:0007596,GO:0007597,GO:0010756,GO:0016485,GO:0016540,GO:0030194,GO:0031638,GO:0042730,GO:0045087,GO:0051787,GO:0051788,GO:0051919,GO:0062023,GO:0070062" "plasma kallikrein-kinin cascade|Factor XII activation|serine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|extracellular space|rough endoplasmic reticulum|plasma membrane|proteolysis|blood coagulation|blood coagulation, intrinsic pathway|positive regulation of plasminogen activation|protein processing|protein autoprocessing|positive regulation of blood coagulation|zymogen activation|fibrinolysis|innate immune response|misfolded protein binding|response to misfolded protein|positive regulation of fibrinolysis|collagen-containing extracellular matrix|extracellular exosome" hsa04610 Complement and coagulation cascades F2R 1556.371136 1693.961511 1418.78076 0.837551946 -0.255749424 0.438685903 1 22.289731 19.47298408 2149 coagulation factor II thrombin receptor "GO:0000186,GO:0001965,GO:0002248,GO:0003105,GO:0004930,GO:0005102,GO:0005515,GO:0005576,GO:0005769,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0005901,GO:0006919,GO:0006954,GO:0007186,GO:0007200,GO:0007204,GO:0007205,GO:0007529,GO:0007596,GO:0008284,GO:0008285,GO:0009611,GO:0009653,GO:0009986,GO:0014068,GO:0015057,GO:0030168,GO:0030193,GO:0030194,GO:0030335,GO:0031094,GO:0031594,GO:0031681,GO:0032496,GO:0032651,GO:0032755,GO:0032757,GO:0032967,GO:0035025,GO:0043123,GO:0043280,GO:0043410,GO:0043524,GO:0043547,GO:0045211,GO:0045217,GO:0045893,GO:0045907,GO:0045987,GO:0046427,GO:0048873,GO:0051209,GO:0051281,GO:0051482,GO:0051928,GO:0051930,GO:0060155,GO:0070374,GO:0070493,GO:0099553,GO:1900134" "activation of MAPKK activity|G-protein alpha-subunit binding|connective tissue replacement involved in inflammatory response wound healing|negative regulation of glomerular filtration|G protein-coupled receptor activity|signaling receptor binding|protein binding|extracellular region|early endosome|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|caveola|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G protein-coupled receptor signaling pathway|establishment of synaptic specificity at neuromuscular junction|blood coagulation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to wounding|anatomical structure morphogenesis|cell surface|positive regulation of phosphatidylinositol 3-kinase signaling|thrombin-activated receptor activity|platelet activation|regulation of blood coagulation|positive regulation of blood coagulation|positive regulation of cell migration|platelet dense tubular network|neuromuscular junction|G-protein beta-subunit binding|response to lipopolysaccharide|regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of collagen biosynthetic process|positive regulation of Rho protein signal transduction|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of MAPK cascade|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|postsynaptic membrane|cell-cell junction maintenance|positive regulation of transcription, DNA-templated|positive regulation of vasoconstriction|positive regulation of smooth muscle contraction|positive regulation of receptor signaling pathway via JAK-STAT|homeostasis of number of cells within a tissue|release of sequestered calcium ion into cytosol|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of calcium ion transport|regulation of sensory perception of pain|platelet dense granule organization|positive regulation of ERK1 and ERK2 cascade|thrombin-activated receptor signaling pathway|trans-synaptic signaling by endocannabinoid, modulating synaptic transmission|negative regulation of renin secretion into blood stream" "hsa04015,hsa04020,hsa04024,hsa04072,hsa04080,hsa04151,hsa04610,hsa04611,hsa04810,hsa05130,hsa05200" Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Complement and coagulation cascades|Platelet activation|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Pathways in cancer F2RL1 254.0913314 396.8477836 111.3348791 0.280548068 -1.833680116 0.000353692 0.04318862 6.695183293 1.959231179 2150 F2R like trypsin receptor 1 "GO:0001965,GO:0002286,GO:0002690,GO:0002720,GO:0003104,GO:0004930,GO:0005102,GO:0005515,GO:0005769,GO:0005794,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007204,GO:0007596,GO:0010804,GO:0014068,GO:0015057,GO:0030193,GO:0030335,GO:0030836,GO:0031143,GO:0031274,GO:0031681,GO:0032602,GO:0032609,GO:0032611,GO:0032613,GO:0032682,GO:0032755,GO:0032757,GO:0032930,GO:0034137,GO:0034140,GO:0034141,GO:0034145,GO:0035025,GO:0038023,GO:0042119,GO:0042311,GO:0043122,GO:0043123,GO:0043311,GO:0043547,GO:0045087,GO:0045217,GO:0045944,GO:0046328,GO:0046329,GO:0046330,GO:0050900,GO:0050921,GO:0050927,GO:0051482,GO:0051607,GO:0060100,GO:0061028,GO:0070374,GO:0070493,GO:0070661,GO:0070963,GO:0097029,GO:1900135,GO:2000341" "G-protein alpha-subunit binding|T cell activation involved in immune response|positive regulation of leukocyte chemotaxis|positive regulation of cytokine production involved in immune response|positive regulation of glomerular filtration|G protein-coupled receptor activity|signaling receptor binding|protein binding|early endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|blood coagulation|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of phosphatidylinositol 3-kinase signaling|thrombin-activated receptor activity|regulation of blood coagulation|positive regulation of cell migration|positive regulation of actin filament depolymerization|pseudopodium|positive regulation of pseudopodium assembly|G-protein beta-subunit binding|chemokine production|interferon-gamma production|interleukin-1 beta production|interleukin-10 production|negative regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of superoxide anion generation|positive regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of Rho protein signal transduction|signaling receptor activity|neutrophil activation|vasodilation|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of eosinophil degranulation|positive regulation of GTPase activity|innate immune response|cell-cell junction maintenance|positive regulation of transcription by RNA polymerase II|regulation of JNK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|leukocyte migration|positive regulation of chemotaxis|positive regulation of positive chemotaxis|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|defense response to virus|positive regulation of phagocytosis, engulfment|establishment of endothelial barrier|positive regulation of ERK1 and ERK2 cascade|thrombin-activated receptor signaling pathway|leukocyte proliferation|positive regulation of neutrophil mediated killing of gram-negative bacterium|mature conventional dendritic cell differentiation|positive regulation of renin secretion into blood stream|regulation of chemokine (C-X-C motif) ligand 2 production" "hsa04080,hsa04750,hsa05143" Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels|African trypanosomiasis F2RL2 12.12008852 20.29911937 3.941057666 0.194149194 -2.364762376 0.086240025 1 0.302554086 0.06127094 2151 coagulation factor II thrombin receptor like 2 "GO:0004435,GO:0004930,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007186,GO:0007596,GO:0009611,GO:0015057,GO:0016324,GO:0030168,GO:0032991,GO:0035025,GO:0051482,GO:0070493" phosphatidylinositol phospholipase C activity|G protein-coupled receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|blood coagulation|response to wounding|thrombin-activated receptor activity|apical plasma membrane|platelet activation|protein-containing complex|positive regulation of Rho protein signal transduction|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|thrombin-activated receptor signaling pathway "hsa04080,hsa04610" Neuroactive ligand-receptor interaction|Complement and coagulation cascades F2RL3 129.1248162 239.5296085 18.72002391 0.078153277 -3.677549817 2.29E-07 0.000124049 3.638671165 0.296623758 9002 F2R like thrombin or trypsin receptor 3 "GO:0004930,GO:0005576,GO:0005886,GO:0005887,GO:0007165,GO:0007186,GO:0007200,GO:0007596,GO:0009611,GO:0015057,GO:0030168,GO:0035025,GO:0051281,GO:0051482,GO:0060155,GO:0070493" G protein-coupled receptor activity|extracellular region|plasma membrane|integral component of plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|blood coagulation|response to wounding|thrombin-activated receptor activity|platelet activation|positive regulation of Rho protein signal transduction|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|platelet dense granule organization|thrombin-activated receptor signaling pathway "hsa04015,hsa04080,hsa04610,hsa04611,hsa05200" Rap1 signaling pathway|Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Platelet activation|Pathways in cancer F3 5779.389375 6522.107053 5036.671697 0.772246094 -0.372867426 0.249574018 1 143.7431304 115.7867193 2152 "coagulation factor III, tissue factor" "GO:0001938,GO:0002020,GO:0002541,GO:0002543,GO:0004252,GO:0004896,GO:0005515,GO:0005543,GO:0005615,GO:0005886,GO:0006919,GO:0007596,GO:0007598,GO:0009986,GO:0010628,GO:0010641,GO:0016021,GO:0016485,GO:0019221,GO:0030335,GO:0031233,GO:0032757,GO:0045766,GO:0050927,GO:0051897,GO:0062023,GO:1905286" "positive regulation of endothelial cell proliferation|protease binding|activation of plasma proteins involved in acute inflammatory response|activation of blood coagulation via clotting cascade|serine-type endopeptidase activity|cytokine receptor activity|protein binding|phospholipid binding|extracellular space|plasma membrane|activation of cysteine-type endopeptidase activity involved in apoptotic process|blood coagulation|blood coagulation, extrinsic pathway|cell surface|positive regulation of gene expression|positive regulation of platelet-derived growth factor receptor signaling pathway|integral component of membrane|protein processing|cytokine-mediated signaling pathway|positive regulation of cell migration|intrinsic component of external side of plasma membrane|positive regulation of interleukin-8 production|positive regulation of angiogenesis|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling|collagen-containing extracellular matrix|serine-type peptidase complex" "hsa04610,hsa04933" Complement and coagulation cascades|AGE-RAGE signaling pathway in diabetic complications F8 133.4182131 128.899408 137.9370183 1.070113668 0.097764049 0.885455601 1 0.708365916 0.790684996 2157 coagulation factor VIII "GO:0000139,GO:0002576,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006888,GO:0006953,GO:0007596,GO:0007597,GO:0016491,GO:0030134,GO:0031093,GO:0033116,GO:0048208,GO:0055114" "Golgi membrane|platelet degranulation|copper ion binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|acute-phase response|blood coagulation|blood coagulation, intrinsic pathway|oxidoreductase activity|COPII-coated ER to Golgi transport vesicle|platelet alpha granule lumen|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating|oxidation-reduction process" hsa04610 Complement and coagulation cascades F8A1 551.2240196 570.4052542 532.0427849 0.932745239 -0.100445004 0.804803131 1 16.92385112 16.46562297 8263 coagulation factor VIII associated 1 "GO:0003674,GO:0005515,GO:0005634,GO:0005769,GO:0016604,GO:0099518,GO:1901799" molecular_function|protein binding|nucleus|early endosome|nuclear body|vesicle cytoskeletal trafficking|negative regulation of proteasomal protein catabolic process F8A2 8.493513748 8.119647747 8.867379749 1.092089217 0.12709072 1 1 0.240908913 0.274427049 474383 coagulation factor VIII associated 2 "GO:0003674,GO:0005515,GO:0005634,GO:0005769,GO:0016604,GO:0099518,GO:1901799" molecular_function|protein binding|nucleus|early endosome|nuclear body|vesicle cytoskeletal trafficking|negative regulation of proteasomal protein catabolic process F8A3 47.10909948 54.80762229 39.41057666 0.719071089 -0.475793689 0.592191472 1 1.626135161 1.219675775 474384 coagulation factor VIII associated 3 "GO:0003674,GO:0005515,GO:0005634,GO:0005769,GO:0016604,GO:0099518,GO:1901799" molecular_function|protein binding|nucleus|early endosome|nuclear body|vesicle cytoskeletal trafficking|negative regulation of proteasomal protein catabolic process FA2H 7.986035764 7.104691779 8.867379749 1.248101962 0.319735798 0.916631795 1 0.080878304 0.105292644 79152 fatty acid 2-hydroxylase "GO:0001949,GO:0005506,GO:0005515,GO:0005783,GO:0005789,GO:0006631,GO:0006633,GO:0006679,GO:0006682,GO:0016020,GO:0016021,GO:0020037,GO:0030148,GO:0030258,GO:0032286,GO:0032287,GO:0042127,GO:0042634,GO:0044857,GO:0046513,GO:0055114,GO:0061436,GO:0080132" sebaceous gland cell differentiation|iron ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|fatty acid biosynthetic process|glucosylceramide biosynthetic process|galactosylceramide biosynthetic process|membrane|integral component of membrane|heme binding|sphingolipid biosynthetic process|lipid modification|central nervous system myelin maintenance|peripheral nervous system myelin maintenance|regulation of cell population proliferation|regulation of hair cycle|plasma membrane raft organization|ceramide biosynthetic process|oxidation-reduction process|establishment of skin barrier|fatty acid alpha-hydroxylase activity FAAH 40.66306504 18.26920743 63.05692266 3.451541228 1.787240717 0.052973791 1 0.453119935 1.631331282 2166 fatty acid amide hydrolase "GO:0004040,GO:0005515,GO:0005789,GO:0005856,GO:0009062,GO:0016021,GO:0017064,GO:0019369,GO:0031090,GO:0047372,GO:0052651,GO:0102077,GO:0103073" amidase activity|protein binding|endoplasmic reticulum membrane|cytoskeleton|fatty acid catabolic process|integral component of membrane|fatty acid amide hydrolase activity|arachidonic acid metabolic process|organelle membrane|acylglycerol lipase activity|monoacylglycerol catabolic process|oleamide hydrolase activity|anandamide amidohydrolase activity hsa04723 Retrograde endocannabinoid signaling FAAP100 522.8025309 547.061267 498.5437948 0.911312544 -0.133982169 0.743439044 1 7.304698986 6.94361451 80233 FA core complex associated protein 100 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0036297,GO:0043240" DNA binding|protein binding|nucleoplasm|cytosol|interstrand cross-link repair|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FAAP20 1029.570885 1109.346873 949.7948976 0.856174854 -0.224022631 0.523622243 1 10.61086036 9.476086084 199990 FA core complex associated protein 20 "GO:0005515,GO:0005654,GO:0005694,GO:0006974,GO:0016604,GO:0019985,GO:0030054,GO:0031593,GO:0036297,GO:0043130,GO:0043240,GO:0046872,GO:0070530,GO:0140036" protein binding|nucleoplasm|chromosome|cellular response to DNA damage stimulus|nuclear body|translesion synthesis|cell junction|polyubiquitin modification-dependent protein binding|interstrand cross-link repair|ubiquitin binding|Fanconi anaemia nuclear complex|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|ubiquitin-dependent protein binding FAAP24 209.7410707 193.85659 225.6255514 1.163878677 0.218940679 0.685260774 1 4.19041929 5.087227055 91442 FA core complex associated protein 24 "GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0036297,GO:0043231,GO:0043240" DNA binding|chromatin binding|protein binding|nucleoplasm|interstrand cross-link repair|intracellular membrane-bounded organelle|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FABP4 6.552676467 10.14955968 2.95579325 0.291223791 -1.779799875 0.306941875 1 0.564258389 0.171403942 2167 fatty acid binding protein 4 "GO:0005324,GO:0005504,GO:0005634,GO:0005737,GO:0005811,GO:0005829,GO:0006469,GO:0009617,GO:0015909,GO:0019433,GO:0036041,GO:0042632,GO:0045892,GO:0050729,GO:0050872,GO:0050873,GO:0051427,GO:0070062,GO:0071285,GO:0071356,GO:0120162" "long-chain fatty acid transporter activity|fatty acid binding|nucleus|cytoplasm|lipid droplet|cytosol|negative regulation of protein kinase activity|response to bacterium|long-chain fatty acid transport|triglyceride catabolic process|long-chain fatty acid binding|cholesterol homeostasis|negative regulation of transcription, DNA-templated|positive regulation of inflammatory response|white fat cell differentiation|brown fat cell differentiation|hormone receptor binding|extracellular exosome|cellular response to lithium ion|cellular response to tumor necrosis factor|positive regulation of cold-induced thermogenesis" "hsa03320,hsa04923" PPAR signaling pathway|Regulation of lipolysis in adipocytes FABP5 1694.017673 2145.616917 1242.418429 0.579049512 -0.788241382 0.016356714 0.564119327 160.7513721 97.09264192 2171 fatty acid binding protein 5 "GO:0001972,GO:0005324,GO:0005504,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006006,GO:0006629,GO:0006656,GO:0008289,GO:0008544,GO:0010829,GO:0014069,GO:0015909,GO:0019433,GO:0030667,GO:0031392,GO:0035360,GO:0035578,GO:0042593,GO:0042802,GO:0043312,GO:0045202,GO:0051930,GO:0070062,GO:0099178,GO:0120162,GO:1990379" retinoic acid binding|long-chain fatty acid transporter activity|fatty acid binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|glucose metabolic process|lipid metabolic process|phosphatidylcholine biosynthetic process|lipid binding|epidermis development|negative regulation of glucose transmembrane transport|postsynaptic density|long-chain fatty acid transport|triglyceride catabolic process|secretory granule membrane|regulation of prostaglandin biosynthetic process|positive regulation of peroxisome proliferator activated receptor signaling pathway|azurophil granule lumen|glucose homeostasis|identical protein binding|neutrophil degranulation|synapse|regulation of sensory perception of pain|extracellular exosome|regulation of retrograde trans-synaptic signaling by endocanabinoid|positive regulation of cold-induced thermogenesis|lipid transport across blood-brain barrier hsa03320 PPAR signaling pathway FABP6 5.56741205 10.14955968 0.985264417 0.097074597 -3.364762376 0.106651607 1 0.666717759 0.067509291 2172 fatty acid binding protein 6 "GO:0005737,GO:0005829,GO:0006629,GO:0006869,GO:0008285,GO:0008289,GO:0016020,GO:0019433" cytoplasm|cytosol|lipid metabolic process|lipid transport|negative regulation of cell population proliferation|lipid binding|membrane|triglyceride catabolic process hsa03320 PPAR signaling pathway FADD 1045.156967 1097.167402 993.1465319 0.905191432 -0.143705165 0.682625865 1 32.5337578 30.71783432 8772 Fas associated via death domain "GO:0001822,GO:0001916,GO:0002020,GO:0002821,GO:0005123,GO:0005164,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0006919,GO:0007166,GO:0008625,GO:0016032,GO:0031264,GO:0031265,GO:0032729,GO:0032757,GO:0032760,GO:0032813,GO:0033077,GO:0033612,GO:0034138,GO:0035666,GO:0035877,GO:0036462,GO:0042104,GO:0042802,GO:0043005,GO:0043029,GO:0043065,GO:0043123,GO:0043278,GO:0044297,GO:0044877,GO:0045087,GO:0045121,GO:0045651,GO:0045862,GO:0045944,GO:0048148,GO:0048535,GO:0048536,GO:0048538,GO:0051607,GO:0060340,GO:0060546,GO:0070236,GO:0071260,GO:0071550,GO:0089720,GO:0097049,GO:0097190,GO:0097191,GO:0097192,GO:0097202,GO:0097342,GO:0097527,GO:1902041,GO:1902042,GO:2000454,GO:2001238" "kidney development|positive regulation of T cell mediated cytotoxicity|protease binding|positive regulation of adaptive immune response|death receptor binding|tumor necrosis factor receptor binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell surface receptor signaling pathway|extrinsic apoptotic signaling pathway via death domain receptors|viral process|death-inducing signaling complex|CD95 death-inducing signaling complex|positive regulation of interferon-gamma production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|tumor necrosis factor receptor superfamily binding|T cell differentiation in thymus|receptor serine/threonine kinase binding|toll-like receptor 3 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|death effector domain binding|TRAIL-activated apoptotic signaling pathway|positive regulation of activated T cell proliferation|identical protein binding|neuron projection|T cell homeostasis|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to morphine|cell body|protein-containing complex binding|innate immune response|membrane raft|positive regulation of macrophage differentiation|positive regulation of proteolysis|positive regulation of transcription by RNA polymerase II|behavioral response to cocaine|lymph node development|spleen development|thymus development|defense response to virus|positive regulation of type I interferon-mediated signaling pathway|negative regulation of necroptotic process|negative regulation of activation-induced cell death of T cells|cellular response to mechanical stimulus|death-inducing signaling complex assembly|caspase binding|motor neuron apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|activation of cysteine-type endopeptidase activity|ripoptosome|necroptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation|positive regulation of extrinsic apoptotic signaling pathway" "hsa01524,hsa04210,hsa04215,hsa04217,hsa04620,hsa04621,hsa04622,hsa04657,hsa04668,hsa05010,hsa05022,hsa05130,hsa05132,hsa05142,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200" Platinum drug resistance|Apoptosis|Apoptosis - multiple species|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection|Chagas disease|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer FADS1 4828.305609 4379.535004 5277.076215 1.204939842 0.26896112 0.401635971 1 48.84562824 61.39132324 3992 fatty acid desaturase 1 "GO:0000248,GO:0005739,GO:0005789,GO:0006355,GO:0006636,GO:0007267,GO:0008654,GO:0009267,GO:0016020,GO:0016021,GO:0016213,GO:0016491,GO:0019216,GO:0036109,GO:0042759,GO:0043231,GO:0043651,GO:0045485,GO:0045595,GO:0046456,GO:0055114,GO:0062076" "C-5 sterol desaturase activity|mitochondrion|endoplasmic reticulum membrane|regulation of transcription, DNA-templated|unsaturated fatty acid biosynthetic process|cell-cell signaling|phospholipid biosynthetic process|cellular response to starvation|membrane|integral component of membrane|linoleoyl-CoA desaturase activity|oxidoreductase activity|regulation of lipid metabolic process|alpha-linolenic acid metabolic process|long-chain fatty acid biosynthetic process|intracellular membrane-bounded organelle|linoleic acid metabolic process|omega-6 fatty acid desaturase activity|regulation of cell differentiation|icosanoid biosynthetic process|oxidation-reduction process|acyl-CoA delta5-desaturase activity" hsa01040 Biosynthesis of unsaturated fatty acids FADS2 1370.159128 1290.009036 1450.309221 1.124262839 0.16897936 0.61536676 1 18.22438125 21.3715774 9415 fatty acid desaturase 2 "GO:0004768,GO:0005789,GO:0005887,GO:0006636,GO:0016020,GO:0016213,GO:0036109,GO:0043651,GO:0055114" stearoyl-CoA 9-desaturase activity|endoplasmic reticulum membrane|integral component of plasma membrane|unsaturated fatty acid biosynthetic process|membrane|linoleoyl-CoA desaturase activity|alpha-linolenic acid metabolic process|linoleic acid metabolic process|oxidation-reduction process "hsa00592,hsa01040,hsa03320" alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway FADS3 2068.508464 2320.189344 1816.827584 0.78305143 -0.352821029 0.272633706 1 53.8293198 43.96682541 3995 fatty acid desaturase 3 "GO:0003674,GO:0005515,GO:0005789,GO:0006636,GO:0006665,GO:0016020,GO:0016021,GO:0016491,GO:0055114" molecular_function|protein binding|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|sphingolipid metabolic process|membrane|integral component of membrane|oxidoreductase activity|oxidation-reduction process FAF1 1337.024602 1213.887338 1460.161865 1.202880877 0.266493777 0.428892455 1 9.151400914 11.48222709 11124 Fas associated factor 1 "GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005829,GO:0006915,GO:0007253,GO:0008219,GO:0010942,GO:0019887,GO:0019901,GO:0019904,GO:0030155,GO:0031072,GO:0031265,GO:0031334,GO:0031625,GO:0034098,GO:0042176,GO:0043065,GO:0043130,GO:0043161,GO:0045740,GO:0045859,GO:0048471,GO:0051059,GO:1902043,GO:1903364" protein binding|nucleus|nuclear envelope|nucleoplasm|cytosol|apoptotic process|cytoplasmic sequestering of NF-kappaB|cell death|positive regulation of cell death|protein kinase regulator activity|protein kinase binding|protein domain specific binding|regulation of cell adhesion|heat shock protein binding|CD95 death-inducing signaling complex|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|VCP-NPL4-UFD1 AAA ATPase complex|regulation of protein catabolic process|positive regulation of apoptotic process|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of DNA replication|regulation of protein kinase activity|perinuclear region of cytoplasm|NF-kappaB binding|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of cellular protein catabolic process hsa04217 Necroptosis FAF2 2919.768263 3161.587841 2677.948684 0.8470265 -0.239520988 0.451791287 1 35.25391254 31.14728885 23197 Fas associated factor family member 2 "GO:0005515,GO:0005576,GO:0005783,GO:0005811,GO:0006986,GO:0030433,GO:0030970,GO:0031625,GO:0034098,GO:0034389,GO:0035473,GO:0035578,GO:0043086,GO:0043130,GO:0043312,GO:0055102" "protein binding|extracellular region|endoplasmic reticulum|lipid droplet|response to unfolded protein|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|ubiquitin protein ligase binding|VCP-NPL4-UFD1 AAA ATPase complex|lipid droplet organization|lipase binding|azurophil granule lumen|negative regulation of catalytic activity|ubiquitin binding|neutrophil degranulation|lipase inhibitor activity" FAH 908.5196958 1084.98793 732.0514615 0.674709313 -0.567662018 0.113623693 1 36.41538175 25.62816444 2184 fumarylacetoacetate hydrolase "GO:0004334,GO:0005515,GO:0005829,GO:0006527,GO:0006559,GO:0006572,GO:0046872,GO:0070062,GO:1902000" fumarylacetoacetase activity|protein binding|cytosol|arginine catabolic process|L-phenylalanine catabolic process|tyrosine catabolic process|metal ion binding|extracellular exosome|homogentisate catabolic process hsa00350 Tyrosine metabolism FAHD1 529.1743364 578.524902 479.8237709 0.829391733 -0.269874428 0.504228114 1 10.6585105 9.220875309 81889 fumarylacetoacetate hydrolase domain containing 1 "GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006099,GO:0008948,GO:0018773,GO:0034545,GO:0046872,GO:0047621" nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|tricarboxylic acid cycle|oxaloacetate decarboxylase activity|acetylpyruvate hydrolase activity|fumarylpyruvate hydrolase activity|metal ion binding|acylpyruvate hydrolase activity hsa00350 Tyrosine metabolism FAHD2A 297.9910216 265.9184637 330.0635795 1.241220993 0.311760003 0.512786392 1 2.638164953 3.415599871 51011 fumarylacetoacetate hydrolase domain containing 2A "GO:0005515,GO:0016787,GO:0016836,GO:0046872" protein binding|hydrolase activity|hydro-lyase activity|metal ion binding FAHD2B 140.5553181 111.6451565 169.4654796 1.517893699 0.60207076 0.321182132 1 1.43005395 2.264173535 151313 fumarylacetoacetate hydrolase domain containing 2B "GO:0016787,GO:0016836,GO:0046872" hydrolase activity|hydro-lyase activity|metal ion binding FAIM 158.3170475 147.1686154 169.4654796 1.151505565 0.203521383 0.733884631 1 3.254834581 3.909407056 55179 Fas apoptotic inhibitory molecule "GO:0005515,GO:0005737,GO:0006915,GO:0007249,GO:0050769,GO:1902042" protein binding|cytoplasm|apoptotic process|I-kappaB kinase/NF-kappaB signaling|positive regulation of neurogenesis|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors FAIM2 5.911586499 0 11.823173 Inf Inf 0.024866408 0.697803913 0 0.129961707 23017 Fas apoptotic inhibitory molecule 2 "GO:0002931,GO:0005515,GO:0005783,GO:0005794,GO:0006915,GO:0016021,GO:0021549,GO:0021680,GO:0021681,GO:0021702,GO:0043066,GO:0043523,GO:0043524,GO:0045121,GO:0045211,GO:1902042" response to ischemia|protein binding|endoplasmic reticulum|Golgi apparatus|apoptotic process|integral component of membrane|cerebellum development|cerebellar Purkinje cell layer development|cerebellar granular layer development|cerebellar Purkinje cell differentiation|negative regulation of apoptotic process|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|membrane raft|postsynaptic membrane|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors FAM102A 1296.025527 1105.28705 1486.764005 1.345138356 0.427754571 0.2060347 1 11.74300185 16.4763882 399665 family with sequence similarity 102 member A GO:0005515 protein binding FAM102B 793.4424435 660.7363354 926.1485516 1.40169157 0.487168932 0.185739295 1 5.99283031 8.761941956 284611 family with sequence similarity 102 member B FAM104A 879.6906902 932.7445349 826.6368455 0.886241425 -0.174228332 0.630459865 1 14.0889413 13.02405841 84923 family with sequence similarity 104 member A GO:0005515 protein binding FAM104B 214.8873578 242.5744764 187.2002391 0.771722738 -0.373845481 0.479982506 1 3.278767409 2.639294397 90736 family with sequence similarity 104 member B FAM106B 6.493293363 6.08973581 6.896850916 1.132536966 0.17955814 1 1 0.205752926 0.243060471 100996259 family with sequence similarity 106 member B FAM107B 686.9069555 753.0973285 620.7165824 0.824218277 -0.278901639 0.462875777 1 7.371805745 6.337705477 83641 family with sequence similarity 107 member B FAM110A 356.2525126 308.5466144 403.9584108 1.309229763 0.388718305 0.387084052 1 5.448674174 7.440851506 83541 family with sequence similarity 110 member A "GO:0000922,GO:0005515,GO:0005737,GO:0005815" spindle pole|protein binding|cytoplasm|microtubule organizing center FAM110C 19.53926319 22.3290313 16.74949508 0.750121886 -0.414803059 0.742804045 1 0.247567133 0.193704966 642273 family with sequence similarity 110 member C "GO:0000922,GO:0005515,GO:0005634,GO:0005815,GO:0005874,GO:0005938,GO:0030335,GO:0043014,GO:0051897,GO:0060491" spindle pole|protein binding|nucleus|microtubule organizing center|microtubule|cell cortex|positive regulation of cell migration|alpha-tubulin binding|positive regulation of protein kinase B signaling|regulation of cell projection assembly FAM111A 1052.114685 899.250988 1204.978381 1.339980047 0.422211519 0.226993636 1 10.9217962 15.26540497 63901 FAM111 trypsin like peptidase A "GO:0000785,GO:0001650,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006508,GO:0006974,GO:0008233,GO:0016032,GO:0016540,GO:0031297,GO:0045071,GO:0106300" chromatin|fibrillar center|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|DNA replication|proteolysis|cellular response to DNA damage stimulus|peptidase activity|viral process|protein autoprocessing|replication fork processing|negative regulation of viral genome replication|protein-DNA covalent cross-linking repair FAM111B 471.710558 455.7152298 487.7058862 1.070198787 0.097878799 0.817636621 1 6.583105739 7.34871179 374393 FAM111 trypsin like peptidase B "GO:0000785,GO:0005515,GO:0005634,GO:0006260,GO:0006508,GO:0008233" chromatin|protein binding|nucleus|DNA replication|proteolysis|peptidase activity FAM114A1 1535.975023 1377.295249 1694.654796 1.230422306 0.299153563 0.365671129 1 10.5529721 13.5439367 92689 family with sequence similarity 114 member A1 "GO:0005515,GO:0005654,GO:0005794,GO:0005829" protein binding|nucleoplasm|Golgi apparatus|cytosol FAM114A2 253.3369184 311.5914823 195.0823545 0.62608372 -0.675572507 0.176282333 1 2.259594695 1.475634796 10827 family with sequence similarity 114 member A2 "GO:0005515,GO:0005575,GO:0008150,GO:0017076" protein binding|cellular_component|biological_process|purine nucleotide binding FAM117A 176.5295935 146.1536594 206.9055275 1.415671207 0.501486235 0.373207492 1 2.206309166 3.257952125 81558 family with sequence similarity 117 member A FAM117B 215.8550548 275.0530674 156.6570422 0.569552064 -0.812100367 0.123112775 1 2.328730782 1.383466488 150864 family with sequence similarity 117 member B GO:0005515 protein binding FAM118A 365.8473354 358.2794568 373.4152139 1.042245674 0.059695384 0.899286888 1 2.977615779 3.237089358 55007 family with sequence similarity 118 member A "GO:0005515,GO:0016021,GO:0042802" protein binding|integral component of membrane|identical protein binding FAM118B 380.4008934 376.5486643 384.2531225 1.020460724 0.029220656 0.95345243 1 7.848091136 8.353649731 79607 family with sequence similarity 118 member B "GO:0005515,GO:0015030,GO:0030576,GO:0042802" protein binding|Cajal body|Cajal body organization|identical protein binding FAM120A 5589.795499 5482.792141 5696.798856 1.039032433 0.055240688 0.864642941 1 29.2452954 31.69575098 23196 family with sequence similarity 120A "GO:0003723,GO:0005634,GO:0005829,GO:0005886,GO:0016020" RNA binding|nucleus|cytosol|plasma membrane|membrane FAM120AOS 795.6072052 842.4134538 748.8009566 0.888875828 -0.169946199 0.645674561 1 6.621957097 6.139646813 158293 family with sequence similarity 120A opposite strand GO:0005515 protein binding FAM120B 547.8943603 578.524902 517.2638187 0.894108131 -0.161478778 0.68869226 1 3.787518792 3.532325937 84498 family with sequence similarity 120B "GO:0005515,GO:0005634,GO:0035357,GO:0045444" protein binding|nucleus|peroxisome proliferator activated receptor signaling pathway|fat cell differentiation FAM120C 573.9957026 679.0055428 468.9858623 0.69069519 -0.533878919 0.176743422 1 4.062040557 2.926487116 54954 family with sequence similarity 120C "GO:0003723,GO:0005634" RNA binding|nucleus FAM124A 31.5405855 34.50850292 28.57266808 0.82798921 -0.272316127 0.805571575 1 0.275624339 0.238044512 220108 family with sequence similarity 124 member A GO:0005515 protein binding FAM126A 1668.166234 1725.425146 1610.907321 0.933629213 -0.099078392 0.763464749 1 6.321832939 6.156492814 84668 family with sequence similarity 126 member A "GO:0005515,GO:0005829,GO:0005886,GO:0042552,GO:0046854,GO:0072659" protein binding|cytosol|plasma membrane|myelination|phosphatidylinositol phosphorylation|protein localization to plasma membrane FAM126B 342.8475225 301.4419226 384.2531225 1.274716931 0.350176912 0.441622606 1 1.422167672 1.890951919 285172 family with sequence similarity 126 member B "GO:0005515,GO:0005829,GO:0005886,GO:0046854,GO:0072659" protein binding|cytosol|plasma membrane|phosphatidylinositol phosphorylation|protein localization to plasma membrane FAM131A 408.228551 359.2944128 457.1626893 1.272390199 0.347541164 0.421260504 1 6.393884221 8.485960633 131408 family with sequence similarity 131 member A FAM131B 9.956564597 7.104691779 12.80843742 1.802813945 0.850250515 0.576368418 1 0.072356239 0.136063871 9715 family with sequence similarity 131 member B "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol FAM131C 24.0768735 29.43372308 18.72002391 0.636005981 -0.652887763 0.549857351 1 0.866694325 0.574967215 348487 family with sequence similarity 131 member C GO:0005515 protein binding FAM133B 225.5619628 231.4099608 219.7139649 0.949457682 -0.074824395 0.893469534 1 3.975609955 3.937271033 257415 family with sequence similarity 133 member B GO:0003723 RNA binding FAM135A 100.9517463 98.45072893 103.4527637 1.050807494 0.071498394 0.930860141 1 0.769116475 0.843007048 57579 family with sequence similarity 135 member A GO:0044255 cellular lipid metabolic process FAM136A 736.6600869 786.5908755 686.7292983 0.873045086 -0.195871936 0.601605889 1 17.29832953 15.75276405 84908 family with sequence similarity 136 member A "GO:0005515,GO:0005737" protein binding|cytoplasm FAM13A 332.5710318 373.5037964 291.6382673 0.780817411 -0.356942872 0.437023727 1 1.654131658 1.347210603 10144 family with sequence similarity 13 member A "GO:0005096,GO:0005829,GO:0007165,GO:0043547,GO:0051056" GTPase activator activity|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction FAM13B 658.8214764 820.0844224 497.5585304 0.606716232 -0.720906186 0.06014501 1 6.664695589 4.217759976 51306 family with sequence similarity 13 member B "GO:0005096,GO:0005829,GO:0007165,GO:0043547,GO:0051056" GTPase activator activity|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction FAM149A 120.6273431 96.420817 144.8338692 1.50210166 0.586982455 0.358491613 1 0.728861825 1.141985159 25854 family with sequence similarity 149 member A FAM149B1 552.1444577 633.3325243 470.9563911 0.743616304 -0.427369692 0.284030685 1 5.57553591 4.324654833 317662 family with sequence similarity 149 member B1 "GO:0005515,GO:0005929,GO:0060271,GO:0061512" protein binding|cilium|cilium assembly|protein localization to cilium FAM151B 30.0478431 33.49354696 26.60213925 0.794246703 -0.332340898 0.760436199 1 0.460834011 0.381782374 167555 family with sequence similarity 151 member B GO:0005515 protein binding FAM155A 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.022644907 0.005732342 728215 family with sequence similarity 155 member A "GO:0005886,GO:0015275,GO:0016021,GO:0098703" "plasma membrane|stretch-activated, cation-selective, calcium channel activity|integral component of membrane|calcium ion import across plasma membrane" FAM156A 14.00154269 14.20938356 13.79370183 0.970745971 -0.042834281 1 1 0.134666009 0.136357652 29057 family with sequence similarity 156 member A "GO:0005515,GO:0005635,GO:0016021,GO:0035064" protein binding|nuclear envelope|integral component of membrane|methylated histone binding FAM156B 7.060154451 11.16451565 2.95579325 0.264748901 -1.917303399 0.254779046 1 0.135015122 0.037284859 727866 family with sequence similarity 156 member B "GO:0005515,GO:0005635,GO:0016021,GO:0035064" protein binding|nuclear envelope|integral component of membrane|methylated histone binding FAM161A 153.2125761 134.9891438 171.4360085 1.269998488 0.344826779 0.5620405 1 1.702795497 2.255701491 84140 FAM161 centrosomal protein A "GO:0000235,GO:0001917,GO:0005515,GO:0005813,GO:0005876,GO:0005929,GO:0007601,GO:0008017,GO:0032391,GO:0036064,GO:0042802,GO:0044782,GO:0050896,GO:0060271,GO:0072686,GO:0097431,GO:1901985" astral microtubule|photoreceptor inner segment|protein binding|centrosome|spindle microtubule|cilium|visual perception|microtubule binding|photoreceptor connecting cilium|ciliary basal body|identical protein binding|cilium organization|response to stimulus|cilium assembly|mitotic spindle|mitotic spindle pole|positive regulation of protein acetylation FAM161B 139.8224319 128.899408 150.7454557 1.169481366 0.225868875 0.717153011 1 1.54078364 1.879537066 145483 FAM161 centrosomal protein B "GO:0005515,GO:0005881,GO:0005929,GO:0008150,GO:0015630,GO:0044782" protein binding|cytoplasmic microtubule|cilium|biological_process|microtubule cytoskeleton|cilium organization FAM162A 858.6908517 1248.395841 468.9858623 0.375670798 -1.412459118 0.000126599 0.019280092 20.7165286 8.117837459 26355 family with sequence similarity 162 member A "GO:0005515,GO:0005739,GO:0005829,GO:0006919,GO:0016021,GO:0043065,GO:0051402,GO:0071456,GO:0090200" protein binding|mitochondrion|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|integral component of membrane|positive regulation of apoptotic process|neuron apoptotic process|cellular response to hypoxia|positive regulation of release of cytochrome c from mitochondria FAM166A 6.971079795 5.074779842 8.867379749 1.747342747 0.805162625 0.671092798 1 0.171689844 0.31292383 401565 family with sequence similarity 166 member A "GO:0005515,GO:0005634,GO:0036064" protein binding|nucleus|ciliary basal body FAM166C 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.023498944 0.035691198 339778 family with sequence similarity 166 member C GO:0005634 nucleus FAM167A 843.0659223 820.0844224 866.0474221 1.056046668 0.078673591 0.831424211 1 7.756187285 8.543726312 83648 family with sequence similarity 167 member A GO:0005515 protein binding FAM167B 11.46415277 9.134603715 13.79370183 1.510049287 0.594595639 0.696434627 1 0.488527406 0.769477605 84734 family with sequence similarity 167 member B FAM168A 2907.746898 2844.921579 2970.572216 1.044166643 0.062351977 0.845538044 1 19.9591691 21.73843137 23201 family with sequence similarity 168 member A "GO:0005515,GO:1905053" protein binding|positive regulation of base-excision repair FAM168B 2559.16693 3094.600748 2023.733112 0.653956124 -0.61273425 0.055216467 1 24.38627832 16.6345121 130074 family with sequence similarity 168 member B "GO:0005886,GO:0016021,GO:0030424,GO:0048471,GO:0070062" plasma membrane|integral component of membrane|axon|perinuclear region of cytoplasm|extracellular exosome FAM169A 327.6825661 275.0530674 380.3120648 1.382686143 0.467473715 0.310154796 1 1.698009207 2.448948097 26049 family with sequence similarity 169 member A "GO:0005515,GO:0005637" protein binding|nuclear inner membrane FAM171A1 1701.291358 1733.544794 1669.037922 0.962789036 -0.054708382 0.868648284 1 18.13632064 18.21361915 221061 family with sequence similarity 171 member A1 "GO:0005515,GO:0005886,GO:0008360,GO:0016021,GO:0043149" protein binding|plasma membrane|regulation of cell shape|integral component of membrane|stress fiber assembly FAM171A2 449.0400738 387.7131799 510.3669678 1.316351866 0.396545178 0.345760646 1 5.955809764 8.177654171 284069 family with sequence similarity 171 member A2 GO:0016021 integral component of membrane FAM171B 354.2050333 336.9653815 371.444685 1.102322985 0.140547001 0.758957489 1 2.977858634 3.423961476 165215 family with sequence similarity 171 member B GO:0016021 integral component of membrane FAM172A 393.0729972 400.9076075 385.2383869 0.960915632 -0.057518327 0.900704209 1 0.541079678 0.542328479 83989 family with sequence similarity 172 member A "GO:0000381,GO:0005515,GO:0005634,GO:0005783,GO:0006397,GO:0008380,GO:0014032,GO:0031048,GO:0035197" "regulation of alternative mRNA splicing, via spliceosome|protein binding|nucleus|endoplasmic reticulum|mRNA processing|RNA splicing|neural crest cell development|heterochromatin assembly by small RNA|siRNA binding" FAM174A 268.6288058 245.6193443 291.6382673 1.187358708 0.247755847 0.616555187 1 9.066875582 11.22937351 345757 family with sequence similarity 174 member A "GO:0005515,GO:0016021" protein binding|integral component of membrane FAM174C 428.9851679 464.8498335 393.1205022 0.845693542 -0.241793133 0.571772994 1 27.06092434 23.87105267 55009 family with sequence similarity 174 member C "GO:0005576,GO:0005737,GO:0016021" extracellular region|cytoplasm|integral component of membrane FAM177A1 821.7897033 679.0055428 964.5738638 1.420568468 0.506468368 0.165982841 1 10.15630105 15.04920873 283635 family with sequence similarity 177 member A1 FAM180A 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.010004659 0.030391006 389558 family with sequence similarity 180 member A GO:0005576 extracellular region FAM183A 44.91588401 39.58328277 50.24848524 1.269437038 0.344188842 0.710598818 1 0.556257944 0.736551845 440585 family with sequence similarity 183 member A GO:0097546 ciliary base FAM184A 57.8579334 48.71788648 66.99798033 1.375223458 0.459666059 0.579271871 1 0.59042572 0.846943559 79632 family with sequence similarity 184 member A "GO:0003674,GO:0005515,GO:0005615,GO:0008150" molecular_function|protein binding|extracellular space|biological_process FAM185A 89.23521537 72.06187375 106.408557 1.476627673 0.562306101 0.427662542 1 1.852629283 2.853484102 222234 family with sequence similarity 185 member A GO:0005515 protein binding FAM189A2 51.02046559 52.77771036 49.26322083 0.933409587 -0.09941781 0.929970433 1 0.746232507 0.72654472 9413 family with sequence similarity 189 member A2 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane FAM189B 2303.934203 2047.166188 2560.702219 1.250852145 0.322911269 0.312756981 1 32.50211457 42.40660689 10712 family with sequence similarity 189 member B "GO:0005515,GO:0008150,GO:0016021,GO:0050699" protein binding|biological_process|integral component of membrane|WW domain binding FAM193A 673.8933988 705.394398 642.3923996 0.910685428 -0.134975295 0.725514035 1 5.773390074 5.484224424 8603 family with sequence similarity 193 member A FAM193B 558.5595628 499.3583364 617.7607892 1.237109194 0.306972846 0.440992309 1 5.719298532 7.380176197 54540 family with sequence similarity 193 member B "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0016607" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|nuclear speck FAM199X 2277.083645 2164.901081 2389.26621 1.10363759 0.1422665 0.657167222 1 14.62903301 16.84061834 139231 "family with sequence similarity 199, X-linked" GO:0005515 protein binding FAM200A 164.8845698 158.3331311 171.4360085 1.082755121 0.114706996 0.851053725 1 2.355762198 2.66058798 221786 family with sequence similarity 200 member A "GO:0005515,GO:0016021" protein binding|integral component of membrane FAM200B 210.3524691 201.9762377 218.7287005 1.082942741 0.114956965 0.83609722 1 2.179246679 2.461658573 285550 family with sequence similarity 200 member B FAM204A 335.2474769 320.726086 349.7688679 1.090553226 0.125060185 0.789350684 1 1.153831851 1.312518157 63877 family with sequence similarity 204 member A GO:0005515 protein binding FAM207A 506.4781201 643.4820839 369.4741562 0.574179399 -0.800426526 0.049997396 1 19.87201066 11.90159993 85395 family with sequence similarity 207 member A "GO:0000462,GO:0005515,GO:0005730,GO:0030686,GO:0030688" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|protein binding|nucleolus|90S preribosome|preribosome, small subunit precursor" FAM209B 3.47811701 2.029911937 4.926322083 2.426864926 1.279093814 0.644064692 1 0.084965189 0.215081255 388799 family with sequence similarity 209 member B "GO:0005634,GO:0016021" nucleus|integral component of membrane FAM20A 8.493513748 8.119647747 8.867379749 1.092089217 0.12709072 1 1 0.041992394 0.047834879 54757 FAM20A golgi associated secretory pathway pseudokinase "GO:0001934,GO:0004674,GO:0005515,GO:0005615,GO:0005737,GO:0005783,GO:0005794,GO:0006468,GO:0009617,GO:0016773,GO:0031214,GO:0043539,GO:0044691,GO:0055074,GO:0070062,GO:0070166,GO:0071902" "positive regulation of protein phosphorylation|protein serine/threonine kinase activity|protein binding|extracellular space|cytoplasm|endoplasmic reticulum|Golgi apparatus|protein phosphorylation|response to bacterium|phosphotransferase activity, alcohol group as acceptor|biomineral tissue development|protein serine/threonine kinase activator activity|tooth eruption|calcium ion homeostasis|extracellular exosome|enamel mineralization|positive regulation of protein serine/threonine kinase activity" FAM20B 1647.927981 1486.910494 1808.945469 1.216579933 0.282831113 0.388609109 1 12.18556165 15.46329815 9917 FAM20B glycosaminoglycan xylosylkinase "GO:0000139,GO:0005515,GO:0005524,GO:0005654,GO:0005794,GO:0006468,GO:0016021,GO:0016301,GO:0016773,GO:0030166,GO:0046872" "Golgi membrane|protein binding|ATP binding|nucleoplasm|Golgi apparatus|protein phosphorylation|integral component of membrane|kinase activity|phosphotransferase activity, alcohol group as acceptor|proteoglycan biosynthetic process|metal ion binding" FAM20C 23997.3976 17466.37726 30528.41795 1.747839148 0.805572421 0.032282779 0.804339684 112.8041814 205.656571 56975 FAM20C golgi associated secretory pathway kinase "GO:0004674,GO:0005515,GO:0005524,GO:0005615,GO:0005788,GO:0005794,GO:0006468,GO:0016773,GO:0030145,GO:0031214,GO:0043687,GO:0044267,GO:0046034,GO:0070062,GO:0070166,GO:0071895,GO:0106310,GO:0106311" "protein serine/threonine kinase activity|protein binding|ATP binding|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|protein phosphorylation|phosphotransferase activity, alcohol group as acceptor|manganese ion binding|biomineral tissue development|post-translational protein modification|cellular protein metabolic process|ATP metabolic process|extracellular exosome|enamel mineralization|odontoblast differentiation|protein serine kinase activity|protein threonine kinase activity" FAM210A 718.4515003 922.5949753 514.3080254 0.557458082 -0.843064769 0.025354462 0.707471111 8.22788885 4.784279707 125228 family with sequence similarity 210 member A "GO:0003674,GO:0005737,GO:0005739,GO:0008150,GO:0016021" molecular_function|cytoplasm|mitochondrion|biological_process|integral component of membrane FAM210B 1921.438572 1729.48497 2113.392173 1.221977762 0.289218031 0.371046548 1 29.32451037 37.37747862 116151 family with sequence similarity 210 member B "GO:0005515,GO:0005739,GO:0005741,GO:0016021,GO:0031224,GO:0043249,GO:0045648,GO:0071392" protein binding|mitochondrion|mitochondrial outer membrane|integral component of membrane|intrinsic component of membrane|erythrocyte maturation|positive regulation of erythrocyte differentiation|cellular response to estradiol stimulus FAM214A 190.872589 183.7070303 198.0381477 1.078010719 0.108371523 0.851553107 1 1.662933513 1.86988068 56204 family with sequence similarity 214 member A GO:0005515 protein binding FAM214B 978.0147342 851.5480575 1104.481411 1.297027691 0.375209281 0.289021332 1 11.99329951 16.22571552 80256 family with sequence similarity 214 member B "GO:0005515,GO:0005634" protein binding|nucleus FAM216A 250.0545181 289.262451 210.8465851 0.728911009 -0.456185404 0.36373344 1 9.242979612 7.027525573 29902 family with sequence similarity 216 member A FAM217B 440.1469619 520.6724118 359.621512 0.690686704 -0.533896643 0.206375191 1 4.960538155 3.573763592 63939 family with sequence similarity 217 member B "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol FAM219A 1429.493475 1540.70316 1318.283789 0.855637753 -0.224927956 0.500586119 1 21.40773108 19.10629631 203259 family with sequence similarity 219 member A FAM219B 1172.72446 1028.150396 1317.298525 1.281231355 0.35753101 0.297784522 1 15.43337002 20.62548915 57184 family with sequence similarity 219 member B GO:0005515 protein binding FAM220A 340.6340181 352.189721 329.0783151 0.934377966 -0.097921841 0.835004511 1 8.034759874 7.830895351 84792 family with sequence similarity 220 member A "GO:0000122,GO:0005515,GO:0005634,GO:0006470,GO:0097677" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|protein dephosphorylation|STAT family protein binding FAM221A 103.2367581 86.27125731 120.2022588 1.393305981 0.47851212 0.479448871 1 1.860082944 2.703303096 340277 family with sequence similarity 221 member A GO:0005515 protein binding FAM222A 18.5985361 25.37389921 11.823173 0.465958066 -1.10172797 0.340345687 1 0.299766382 0.14569535 84915 family with sequence similarity 222 member A FAM222B 704.0654513 680.0204988 728.1104038 1.070718317 0.098578988 0.796763374 1 4.496754054 5.022157133 55731 family with sequence similarity 222 member B "GO:0005515,GO:0005654" protein binding|nucleoplasm FAM227A 105.9374515 102.5105528 109.3643502 1.066859433 0.093370102 0.902262039 1 0.483722898 0.538294295 646851 family with sequence similarity 227 member A FAM227B 16.53893262 19.2841634 13.79370183 0.715286505 -0.483406873 0.715031449 1 0.123022402 0.091786786 196951 family with sequence similarity 227 member B FAM228B 53.7535722 37.55337083 69.95377357 1.862782808 0.897459473 0.28145808 1 1.135490001 2.206284253 375190 family with sequence similarity 228 member B FAM229A 21.95788691 19.2841634 24.63161041 1.27729733 0.353094395 0.775922981 1 1.397245845 1.861575955 100128071 family with sequence similarity 229 member A FAM229B 99.58989431 140.0639236 59.11586499 0.422063465 -1.244468142 0.068723157 1 10.86331335 4.782511214 619208 family with sequence similarity 229 member B GO:0005515 protein binding FAM234A 1172.203374 1194.603175 1149.803574 0.962498341 -0.055144041 0.874643369 1 14.35407746 14.41090333 83986 family with sequence similarity 234 member A "GO:0003674,GO:0008150,GO:0009986,GO:0016021,GO:0070062" molecular_function|biological_process|cell surface|integral component of membrane|extracellular exosome FAM234B 720.289901 711.4841338 729.0956682 1.024753236 0.035276545 0.928919733 1 7.648941077 8.175918307 57613 family with sequence similarity 234 member B "GO:0005856,GO:0016021,GO:0150051" cytoskeleton|integral component of membrane|postsynaptic Golgi apparatus FAM241A 206.7083269 222.2753571 191.1412968 0.85993022 -0.217708499 0.688436103 1 1.272892661 1.141749747 132720 family with sequence similarity 241 member A "GO:0005794,GO:0016021,GO:0043231" Golgi apparatus|integral component of membrane|intracellular membrane-bounded organelle FAM241B 33.52596011 35.52345889 31.52846133 0.887539173 -0.172117298 0.886634916 1 0.884097235 0.81847137 219738 family with sequence similarity 241 member B "GO:0005515,GO:0016021,GO:0043231" protein binding|integral component of membrane|intracellular membrane-bounded organelle FAM24B 19.98735807 19.2841634 20.69055275 1.072929757 0.101555628 0.977329228 1 1.288489242 1.442009153 196792 family with sequence similarity 24 member B "GO:0005515,GO:0005576" protein binding|extracellular region FAM32A 1086.4584 1159.079716 1013.837085 0.874691422 -0.19315395 0.579259872 1 34.75624548 31.71054112 26017 family with sequence similarity 32 member A "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006915,GO:0007049,GO:0008150" RNA binding|protein binding|nucleoplasm|nucleolus|apoptotic process|cell cycle|biological_process FAM3A 827.1289855 740.9178569 913.3401141 1.232714404 0.301838594 0.408682462 1 19.77074586 25.42151647 60343 FAM3 metabolism regulating signaling molecule A "GO:0003674,GO:0005575,GO:0005615,GO:0019732,GO:0045721,GO:0046890,GO:0061844,GO:1905035" molecular_function|cellular_component|extracellular space|antifungal humoral response|negative regulation of gluconeogenesis|regulation of lipid biosynthetic process|antimicrobial humoral immune response mediated by antimicrobial peptide|negative regulation of antifungal innate immune response FAM3C 2159.194852 1986.26883 2332.120874 1.174121468 0.231581669 0.470519911 1 36.17314243 44.30117008 10447 FAM3 metabolism regulating signaling molecule C "GO:0002576,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0007165,GO:0007275,GO:0008150,GO:0031089,GO:0045721,GO:0070062" platelet degranulation|cytokine activity|protein binding|extracellular region|extracellular space|Golgi apparatus|signal transduction|multicellular organism development|biological_process|platelet dense granule lumen|negative regulation of gluconeogenesis|extracellular exosome FAM43A 734.2238958 822.1143344 646.3334573 0.786184391 -0.347060374 0.353594061 1 13.19720786 10.82237065 131583 family with sequence similarity 43 member A GO:0005515 protein binding FAM43B 6.463601811 4.059823873 8.867379749 2.184178434 1.12709072 0.538620937 1 0.083993365 0.191359058 163933 family with sequence similarity 43 member B FAM47E 4.463381426 2.029911937 6.896850916 3.397610897 1.764520641 0.414871268 1 0.05069422 0.179658603 100129583 family with sequence similarity 47 member E "GO:0003674,GO:0005737,GO:0008150" molecular_function|cytoplasm|biological_process FAM50A 2580.592098 2504.91133 2656.272867 1.060425906 0.084643821 0.79148638 1 94.88775024 104.9557916 9130 family with sequence similarity 50 member A "GO:0003723,GO:0005634,GO:0005654,GO:0006325,GO:0007283" RNA binding|nucleus|nucleoplasm|chromatin organization|spermatogenesis FAM53A 24.89883438 18.26920743 31.52846133 1.725770614 0.787240717 0.460488023 1 0.156852162 0.282351117 152877 family with sequence similarity 53 member A "GO:0005634,GO:0006606" nucleus|protein import into nucleus FAM53B 298.3918576 293.3222749 303.4614403 1.03456664 0.049026577 0.924797019 1 2.579569099 2.783694465 9679 family with sequence similarity 53 member B "GO:0005634,GO:0006606,GO:0016055,GO:0060828,GO:0090263" nucleus|protein import into nucleus|Wnt signaling pathway|regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway FAM53C 1884.277872 1782.26268 1986.293064 1.11447829 0.156368513 0.629746945 1 20.39894177 23.71347391 51307 family with sequence similarity 53 member C "GO:0005515,GO:0005634,GO:0006606" protein binding|nucleus|protein import into nucleus FAM71D 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.054568938 0 161142 family with sequence similarity 71 member D FAM71E1 16.46470374 14.20938356 18.72002391 1.31744096 0.39773831 0.775274639 1 0.473457335 0.650620796 112703 family with sequence similarity 71 member E1 FAM71F2 13.04596983 16.23929549 9.852644165 0.606716232 -0.720906186 0.599404122 1 0.211158672 0.133631999 346653 family with sequence similarity 71 member F2 FAM72A 139.5848994 112.6601125 166.5096864 1.477982604 0.563629289 0.354457531 1 1.175491812 1.812194719 729533 family with sequence similarity 72 member A "GO:0005515,GO:0005739,GO:0005829,GO:0016020,GO:0043231" protein binding|mitochondrion|cytosol|membrane|intracellular membrane-bounded organelle FAM72B 210.0852451 183.7070303 236.46346 1.287176977 0.364210427 0.494900811 1 3.919171442 5.261971057 653820 family with sequence similarity 72 member B "GO:0005829,GO:0016020,GO:0043231" cytosol|membrane|intracellular membrane-bounded organelle FAM72C 36.39267871 29.43372308 43.35163433 1.472855955 0.558616342 0.560827267 1 0.511218875 0.785385872 554282 family with sequence similarity 72 member C "GO:0005829,GO:0016020,GO:0043231" cytosol|membrane|intracellular membrane-bounded organelle FAM72D 116.5972108 90.33108119 142.8633404 1.581552424 0.661341378 0.305888853 1 1.045942065 1.725468961 728833 family with sequence similarity 72 member D "GO:0005515,GO:0005829,GO:0016020,GO:0043231" protein binding|cytosol|membrane|intracellular membrane-bounded organelle FAM76A 135.4035878 129.914364 140.8928116 1.084505264 0.117037056 0.859452638 1 1.273902076 1.441065229 199870 family with sequence similarity 76 member A GO:0005654 nucleoplasm FAM76B 316.6516624 261.8586398 371.444685 1.418493143 0.504359177 0.278514487 1 3.243388683 4.798905164 143684 family with sequence similarity 76 member B "GO:0005515,GO:0016607" protein binding|nuclear speck FAM78A 107.890413 134.9891438 80.79168216 0.598505034 -0.740564712 0.263475261 1 1.356492841 0.846839767 286336 family with sequence similarity 78 member A GO:0005515 protein binding FAM78B 6.971079795 5.074779842 8.867379749 1.747342747 0.805162625 0.671092798 1 0.023579789 0.042976787 149297 family with sequence similarity 78 member B FAM81A 28.07731427 33.49354696 22.66108158 0.676580525 -0.563666445 0.590620908 1 0.390949526 0.275902804 145773 family with sequence similarity 81 member A GO:0005515 protein binding FAM83A 41.54168743 44.65806261 38.42531225 0.860433928 -0.216863681 0.831722718 1 0.477570382 0.42861843 84985 family with sequence similarity 83 member A "GO:0005515,GO:0005737,GO:0007165,GO:0007173,GO:0008283,GO:0019901,GO:0036312,GO:0042802" protein binding|cytoplasm|signal transduction|epidermal growth factor receptor signaling pathway|cell population proliferation|protein kinase binding|phosphatidylinositol 3-kinase regulatory subunit binding|identical protein binding FAM83B 38.82614819 27.40381115 50.24848524 1.833631278 0.874703559 0.343396918 1 0.270652566 0.517654612 222584 family with sequence similarity 83 member B "GO:0004630,GO:0005154,GO:0005515,GO:0005737,GO:0007165,GO:0007173,GO:0008283,GO:0016020,GO:0019901,GO:0036312,GO:0036313" phospholipase D activity|epidermal growth factor receptor binding|protein binding|cytoplasm|signal transduction|epidermal growth factor receptor signaling pathway|cell population proliferation|membrane|protein kinase binding|phosphatidylinositol 3-kinase regulatory subunit binding|phosphatidylinositol 3-kinase catalytic subunit binding FAM83D 2138.312542 2141.557093 2135.067991 0.996969914 -0.004378127 0.99076487 1 38.44817859 39.9828505 81610 family with sequence similarity 83 member D "GO:0001837,GO:0005515,GO:0005737,GO:0005819,GO:0005829,GO:0007165,GO:0008017,GO:0008283,GO:0015630,GO:0016477,GO:0019894,GO:0019901,GO:0032006,GO:0042176,GO:0045171,GO:0051301,GO:0051310,GO:0070372,GO:0072686,GO:0097431,GO:1902480,GO:1902808" epithelial to mesenchymal transition|protein binding|cytoplasm|spindle|cytosol|signal transduction|microtubule binding|cell population proliferation|microtubule cytoskeleton|cell migration|kinesin binding|protein kinase binding|regulation of TOR signaling|regulation of protein catabolic process|intercellular bridge|cell division|metaphase plate congression|regulation of ERK1 and ERK2 cascade|mitotic spindle|mitotic spindle pole|protein localization to mitotic spindle|positive regulation of cell cycle G1/S phase transition FAM83G 957.2351068 845.4583217 1069.011892 1.26441702 0.338472361 0.340751224 1 8.006634516 10.55981397 644815 family with sequence similarity 83 member G "GO:0005515,GO:0005634,GO:0005829,GO:0007165,GO:0019901,GO:0030509" protein binding|nucleus|cytosol|signal transduction|protein kinase binding|BMP signaling pathway FAM83H 2546.09176 2335.413683 2756.769837 1.18042035 0.239300698 0.453233065 1 21.00150288 25.85847995 286077 family with sequence similarity 83 member H "GO:0005515,GO:0005737,GO:0007165,GO:0019901,GO:0030335,GO:0031214,GO:0044380,GO:0045095,GO:0045104,GO:1990254" protein binding|cytoplasm|signal transduction|protein kinase binding|positive regulation of cell migration|biomineral tissue development|protein localization to cytoskeleton|keratin filament|intermediate filament cytoskeleton organization|keratin filament binding FAM86B1 35.5855636 41.6131947 29.5579325 0.71030193 -0.49349569 0.613036513 1 0.493689742 0.365774165 85002 family with sequence similarity 86 member B1 "GO:0008168,GO:0032259" methyltransferase activity|methylation FAM86B2 17.12063948 25.37389921 8.867379749 0.349468549 -1.51676547 0.200683113 1 0.510364766 0.186039306 653333 family with sequence similarity 86 member B2 "GO:0005515,GO:0008150,GO:0008168,GO:0032259,GO:0032991" protein binding|biological_process|methyltransferase activity|methylation|protein-containing complex FAM89A 164.6942963 111.6451565 217.7434361 1.950316904 0.963708565 0.094596548 1 3.762098016 7.653343765 375061 family with sequence similarity 89 member A FAM89B 534.6972111 585.6295938 483.7648285 0.826059396 -0.275682576 0.493900062 1 23.52107292 20.26676041 23625 family with sequence similarity 89 member B "GO:0001222,GO:0005737,GO:0030010,GO:0030027,GO:0030335,GO:0030512,GO:0060392" transcription corepressor binding|cytoplasm|establishment of cell polarity|lamellipodium|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of SMAD protein signal transduction FAM8A1 281.7462829 300.4269666 263.0655992 0.875639102 -0.191591715 0.695666294 1 3.219544227 2.940596744 51439 family with sequence similarity 8 member A1 "GO:0000839,GO:0005515,GO:0016021" Hrd1p ubiquitin ligase ERAD-L complex|protein binding|integral component of membrane FAM91A1 3650.923288 3538.136506 3763.710071 1.063754907 0.089165788 0.77989555 1 30.68918175 34.05201496 157769 family with sequence similarity 91 member A1 "GO:0005515,GO:0005802,GO:0006886,GO:0031410,GO:0099041" protein binding|trans-Golgi network|intracellular protein transport|cytoplasmic vesicle|vesicle tethering to Golgi FAM98A 1205.232497 1465.596418 944.8685755 0.644699021 -0.633302303 0.06438416 1 26.98192958 18.14453926 25940 family with sequence similarity 98 member A "GO:0003723,GO:0005515,GO:0006479,GO:0008276,GO:0008284,GO:0010628,GO:0032418,GO:0072669,GO:1900029" RNA binding|protein binding|protein methylation|protein methyltransferase activity|positive regulation of cell population proliferation|positive regulation of gene expression|lysosome localization|tRNA-splicing ligase complex|positive regulation of ruffle assembly FAM98B 750.7561475 739.9029009 761.609394 1.029336948 0.041715318 0.914317157 1 8.539988995 9.169186428 283742 family with sequence similarity 98 member B "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006388,GO:0006479,GO:0008276,GO:0008284,GO:0010628,GO:0042802,GO:0043231,GO:0072669" "RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|tRNA splicing, via endonucleolytic cleavage and ligation|protein methylation|protein methyltransferase activity|positive regulation of cell population proliferation|positive regulation of gene expression|identical protein binding|intracellular membrane-bounded organelle|tRNA-splicing ligase complex" FAM98C 140.4338303 137.0190557 143.8486048 1.04984379 0.070174681 0.919645565 1 5.396214462 5.90921532 147965 family with sequence similarity 98 member C "GO:0005515,GO:0072669" protein binding|tRNA-splicing ligase complex FAN1 534.3584799 528.7920595 539.9249003 1.021053343 0.030058239 0.945303164 1 4.389682404 4.67517058 22909 FANCD2 and FANCI associated nuclease 1 "GO:0000287,GO:0000724,GO:0004528,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006289,GO:0008409,GO:0017108,GO:0033683,GO:0036297,GO:0045171,GO:0070336,GO:0140036" "magnesium ion binding|double-strand break repair via homologous recombination|phosphodiesterase I activity|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|nucleotide-excision repair|5'-3' exonuclease activity|5'-flap endonuclease activity|nucleotide-excision repair, DNA incision|interstrand cross-link repair|intercellular bridge|flap-structured DNA binding|ubiquitin-dependent protein binding" hsa03460 Fanconi anemia pathway FANCA 1032.142172 880.9817805 1183.302564 1.343163491 0.425634922 0.224742759 1 7.217505543 10.11188064 2175 FA complementation group A "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0007140,GO:0008584,GO:0008585,GO:0036297,GO:0042127,GO:0043240,GO:0045589,GO:0050727,GO:0051090,GO:0065003,GO:2000348" protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|male meiotic nuclear division|male gonad development|female gonad development|interstrand cross-link repair|regulation of cell population proliferation|Fanconi anaemia nuclear complex|regulation of regulatory T cell differentiation|regulation of inflammatory response|regulation of DNA-binding transcription factor activity|protein-containing complex assembly|regulation of CD40 signaling pathway hsa03460 Fanconi anemia pathway FANCB 339.6960126 321.741042 357.6509832 1.111611316 0.152652427 0.741719348 1 2.119543281 2.457599886 2187 FA complementation group B "GO:0005515,GO:0005654,GO:0036297,GO:0043240,GO:1905168,GO:1990414,GO:2000042" protein binding|nucleoplasm|interstrand cross-link repair|Fanconi anaemia nuclear complex|positive regulation of double-strand break repair via homologous recombination|replication-born double-strand break repair via sister chromatid exchange|negative regulation of double-strand break repair via homologous recombination hsa03460 Fanconi anemia pathway FANCC 485.4448767 451.6554059 519.2343475 1.149625003 0.201163345 0.627495371 1 2.44414499 2.930887143 2176 FA complementation group C "GO:0002262,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006289,GO:0007281,GO:0019430,GO:0034599,GO:0036297,GO:0043240,GO:0048854,GO:0065003,GO:0097150" myeloid cell homeostasis|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|nucleotide-excision repair|germ cell development|removal of superoxide radicals|cellular response to oxidative stress|interstrand cross-link repair|Fanconi anaemia nuclear complex|brain morphogenesis|protein-containing complex assembly|neuronal stem cell population maintenance hsa03460 Fanconi anemia pathway FANCD2 1796.953802 1706.140983 1887.766622 1.106454063 0.145943555 0.654246757 1 14.57904874 16.82590782 2177 FA complementation group D2 "GO:0000793,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0007129,GO:0007276,GO:0010332,GO:0016604,GO:0031573,GO:0034599,GO:0036297,GO:0045589,GO:0048854,GO:0050727,GO:0051090,GO:0070182,GO:0097150,GO:1990918,GO:2000348" condensed chromosome|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|homologous chromosome pairing at meiosis|gamete generation|response to gamma radiation|nuclear body|intra-S DNA damage checkpoint|cellular response to oxidative stress|interstrand cross-link repair|regulation of regulatory T cell differentiation|brain morphogenesis|regulation of inflammatory response|regulation of DNA-binding transcription factor activity|DNA polymerase binding|neuronal stem cell population maintenance|double-strand break repair involved in meiotic recombination|regulation of CD40 signaling pathway hsa03460 Fanconi anemia pathway other FANCE 198.5617092 170.5126027 226.6108158 1.32899746 0.410338347 0.449662298 1 3.165638487 4.388351412 2178 FA complementation group E "GO:0003674,GO:0005634,GO:0005654,GO:0036297,GO:0043240" molecular_function|nucleus|nucleoplasm|interstrand cross-link repair|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FANCF 292.6314504 269.9782876 315.2846133 1.167814701 0.223811378 0.642328878 1 4.154800316 5.061042961 2188 FA complementation group F "GO:0003674,GO:0005515,GO:0005654,GO:0006974,GO:0008150,GO:0036297,GO:0043240" molecular_function|protein binding|nucleoplasm|cellular response to DNA damage stimulus|biological_process|interstrand cross-link repair|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FANCG 1798.089008 1514.314305 2081.863712 1.374789702 0.45921095 0.158029754 1 30.00574232 43.02853655 2189 FA complementation group G "GO:0001541,GO:0003684,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005829,GO:0005886,GO:0006281,GO:0006974,GO:0007005,GO:0007286,GO:0009314,GO:0036297,GO:0043240" ovarian follicle development|damaged DNA binding|protein binding|nucleoplasm|nucleolus|mitochondrion|cytosol|plasma membrane|DNA repair|cellular response to DNA damage stimulus|mitochondrion organization|spermatid development|response to radiation|interstrand cross-link repair|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FANCI 4624.5793 3283.382558 5965.776042 1.816960387 0.861526966 0.007471835 0.354102287 34.84008872 66.02990022 55215 FA complementation group I "GO:0003677,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007049,GO:0016020,GO:0031398,GO:0036297,GO:0070182" DNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|cell cycle|membrane|positive regulation of protein ubiquitination|interstrand cross-link repair|DNA polymerase binding hsa03460 Fanconi anemia pathway FANCL 238.6430674 182.6920743 294.5940605 1.612516918 0.689314297 0.17611341 1 4.211519829 7.083682043 55120 FA complementation group L "GO:0004842,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0006281,GO:0006513,GO:0006974,GO:0007276,GO:0016604,GO:0031625,GO:0036297,GO:0042127,GO:0043231,GO:0043240,GO:0046872,GO:0061630" ubiquitin-protein transferase activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|DNA repair|protein monoubiquitination|cellular response to DNA damage stimulus|gamete generation|nuclear body|ubiquitin protein ligase binding|interstrand cross-link repair|regulation of cell population proliferation|intracellular membrane-bounded organelle|Fanconi anaemia nuclear complex|metal ion binding|ubiquitin protein ligase activity "hsa03460,hsa04120" Fanconi anemia pathway|Ubiquitin mediated proteolysis FANCM 358.7871809 347.1149412 370.4594206 1.06725288 0.093902056 0.839230799 1 2.547478224 2.835918498 57697 FA complementation group M "GO:0000400,GO:0000712,GO:0003682,GO:0003724,GO:0004518,GO:0005515,GO:0005524,GO:0005654,GO:0009378,GO:0031297,GO:0032508,GO:0036297,GO:0043138,GO:0043240,GO:0045003,GO:0071821,GO:0071932,GO:0090305,GO:1902527" four-way junction DNA binding|resolution of meiotic recombination intermediates|chromatin binding|RNA helicase activity|nuclease activity|protein binding|ATP binding|nucleoplasm|four-way junction helicase activity|replication fork processing|DNA duplex unwinding|interstrand cross-link repair|3'-5' DNA helicase activity|Fanconi anaemia nuclear complex|double-strand break repair via synthesis-dependent strand annealing|FANCM-MHF complex|replication fork reversal|nucleic acid phosphodiester bond hydrolysis|positive regulation of protein monoubiquitination hsa03460 Fanconi anemia pathway FANK1 31.01826174 32.47859099 29.5579325 0.910074347 -0.135943686 0.922810365 1 0.446021165 0.423397481 92565 fibronectin type III and ankyrin repeat domains 1 "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005929,GO:0036064,GO:0042981,GO:0043065,GO:0043066,GO:0045893,GO:0051091,GO:0097546" "chromatin|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cilium|ciliary basal body|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|ciliary base" FAR1 1982.248093 2013.672641 1950.823545 0.968788821 -0.045745877 0.888625929 1 19.35941827 19.56308545 84188 fatty acyl-CoA reductase 1 "GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0005782,GO:0008611,GO:0010025,GO:0016491,GO:0035336,GO:0043231,GO:0046474,GO:0055114,GO:0080019,GO:0102965" protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|peroxisomal matrix|ether lipid biosynthetic process|wax biosynthetic process|oxidoreductase activity|long-chain fatty-acyl-CoA metabolic process|intracellular membrane-bounded organelle|glycerophospholipid biosynthetic process|oxidation-reduction process|fatty-acyl-CoA reductase (alcohol-forming) activity|alcohol-forming fatty acyl-CoA reductase activity hsa04146 Peroxisome FAR2 436.6770097 418.161859 455.1921604 1.088554948 0.122414233 0.776461411 1 3.68512667 4.18426042 55711 fatty acyl-CoA reductase 2 "GO:0005777,GO:0005779,GO:0005782,GO:0006629,GO:0010025,GO:0016491,GO:0035336,GO:0043231,GO:0055114,GO:0080019,GO:0102965" peroxisome|integral component of peroxisomal membrane|peroxisomal matrix|lipid metabolic process|wax biosynthetic process|oxidoreductase activity|long-chain fatty-acyl-CoA metabolic process|intracellular membrane-bounded organelle|oxidation-reduction process|fatty-acyl-CoA reductase (alcohol-forming) activity|alcohol-forming fatty acyl-CoA reductase activity hsa04146 Peroxisome FARP1 1300.040814 1110.361829 1489.719798 1.341652566 0.42401112 0.20982275 1 7.563673105 10.58494842 10160 "FERM, ARH/RhoGEF and pleckstrin domain protein 1" "GO:0005085,GO:0005515,GO:0005829,GO:0005856,GO:0007416,GO:0008092,GO:0010923,GO:0030175,GO:0030425,GO:0031234,GO:0043197,GO:0048813" guanyl-nucleotide exchange factor activity|protein binding|cytosol|cytoskeleton|synapse assembly|cytoskeletal protein binding|negative regulation of phosphatase activity|filopodium|dendrite|extrinsic component of cytoplasmic side of plasma membrane|dendritic spine|dendrite morphogenesis FARP2 169.122543 178.6322504 159.6128355 0.893527541 -0.162415897 0.783379198 1 1.57559967 1.46848581 9855 "FERM, ARH/RhoGEF and pleckstrin domain protein 2" "GO:0005085,GO:0005737,GO:0005829,GO:0005856,GO:0007155,GO:0008092,GO:0016322,GO:0016601,GO:0022405,GO:0030316,GO:0031532,GO:0033623,GO:0050790,GO:0071526,GO:0071800" guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|cytoskeleton|cell adhesion|cytoskeletal protein binding|neuron remodeling|Rac protein signal transduction|hair cycle process|osteoclast differentiation|actin cytoskeleton reorganization|regulation of integrin activation|regulation of catalytic activity|semaphorin-plexin signaling pathway|podosome assembly "hsa04015,hsa04520" Rap1 signaling pathway|Adherens junction FARS2 139.6712525 152.2433953 127.0991097 0.834841535 -0.260425716 0.674352882 1 1.163687125 1.013342381 10667 "phenylalanyl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0004826,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0006418,GO:0006432,GO:0008033" tRNA binding|phenylalanine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|phenylalanyl-tRNA aminoacylation|tRNA processing hsa00970 Aminoacyl-tRNA biosynthesis FARSA 1298.286044 1394.549501 1202.022588 0.861943293 -0.214335138 0.526650421 1 39.00000692 35.06382646 2193 phenylalanyl-tRNA synthetase subunit alpha "GO:0000049,GO:0003723,GO:0004826,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006418,GO:0006432,GO:0009328,GO:0016020,GO:0051290" tRNA binding|RNA binding|phenylalanine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|tRNA aminoacylation for protein translation|phenylalanyl-tRNA aminoacylation|phenylalanine-tRNA ligase complex|membrane|protein heterotetramerization hsa00970 Aminoacyl-tRNA biosynthesis FARSB 999.4109571 1169.229276 829.5926387 0.709520926 -0.49508286 0.160277784 1 6.442970081 4.768340424 10056 phenylalanyl-tRNA synthetase subunit beta "GO:0000287,GO:0003723,GO:0004826,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006432,GO:0009328,GO:0016020,GO:0051290" magnesium ion binding|RNA binding|phenylalanine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|phenylalanyl-tRNA aminoacylation|phenylalanine-tRNA ligase complex|membrane|protein heterotetramerization hsa00970 Aminoacyl-tRNA biosynthesis FAS 1355.37076 1222.006986 1488.734533 1.218270068 0.284833987 0.396837661 1 7.726634564 9.818606974 355 Fas cell surface death receptor "GO:0001934,GO:0005031,GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0006915,GO:0006919,GO:0006924,GO:0006955,GO:0007165,GO:0009897,GO:0009986,GO:0016021,GO:0016604,GO:0019900,GO:0031264,GO:0031265,GO:0032872,GO:0033209,GO:0034198,GO:0036337,GO:0038023,GO:0042802,GO:0042981,GO:0043065,GO:0043066,GO:0045121,GO:0065003,GO:0070062,GO:0071260,GO:0071455,GO:0097049,GO:0097190,GO:0097191,GO:0097192,GO:0097527,GO:1902041,GO:1902042,GO:2001235,GO:2001269" positive regulation of protein phosphorylation|tumor necrosis factor-activated receptor activity|protein binding|calmodulin binding|cytosol|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|activation-induced cell death of T cells|immune response|signal transduction|external side of plasma membrane|cell surface|integral component of membrane|nuclear body|kinase binding|death-inducing signaling complex|CD95 death-inducing signaling complex|regulation of stress-activated MAPK cascade|tumor necrosis factor-mediated signaling pathway|cellular response to amino acid starvation|Fas signaling pathway|signaling receptor activity|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|membrane raft|protein-containing complex assembly|extracellular exosome|cellular response to mechanical stimulus|cellular response to hyperoxia|motor neuron apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|necroptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of apoptotic signaling pathway|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway "hsa01524,hsa04010,hsa04060,hsa04115,hsa04210,hsa04217,hsa04650,hsa04668,hsa04932,hsa04940,hsa05010,hsa05022,hsa05130,hsa05142,hsa05143,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05205,hsa05320,hsa05330,hsa05332" Platinum drug resistance|MAPK signaling pathway|Cytokine-cytokine receptor interaction|p53 signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|TNF signaling pathway|Non-alcoholic fatty liver disease|Type I diabetes mellitus|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Chagas disease|African trypanosomiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease FASN 3148.616585 3550.315977 2746.917193 0.773710625 -0.370134009 0.244758174 1 21.24420835 17.1449034 2194 fatty acid synthase "GO:0001649,GO:0002068,GO:0003723,GO:0004313,GO:0004314,GO:0004315,GO:0004316,GO:0004317,GO:0004320,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0006084,GO:0006631,GO:0006633,GO:0008611,GO:0008659,GO:0008693,GO:0016020,GO:0016295,GO:0016296,GO:0030223,GO:0030224,GO:0030879,GO:0031177,GO:0031325,GO:0042470,GO:0042587,GO:0042802,GO:0045296,GO:0045540,GO:0046949,GO:0047117,GO:0047451,GO:0055114,GO:0070062,GO:0071353,GO:0090557,GO:0102131,GO:0102132" "osteoblast differentiation|glandular epithelial cell development|RNA binding|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|protein binding|Golgi apparatus|cytosol|plasma membrane|acetyl-CoA metabolic process|fatty acid metabolic process|fatty acid biosynthetic process|ether lipid biosynthetic process|(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity|3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity|membrane|myristoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|neutrophil differentiation|monocyte differentiation|mammary gland development|phosphopantetheine binding|positive regulation of cellular metabolic process|melanosome|glycogen granule|identical protein binding|cadherin binding|regulation of cholesterol biosynthetic process|fatty-acyl-CoA biosynthetic process|enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity|3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity|oxidation-reduction process|extracellular exosome|cellular response to interleukin-4|establishment of endothelial intestinal barrier|3-oxo-glutaryl-[acp] methyl ester reductase activity|3-oxo-pimeloyl-[acp] methyl ester reductase activity" "hsa00061,hsa04152,hsa04910" Fatty acid biosynthesis|AMPK signaling pathway|Insulin signaling pathway FASTK 1333.689499 1288.99408 1378.384919 1.069349301 0.096733184 0.775494852 1 28.49541809 31.78414645 10922 Fas activated serine/threonine kinase "GO:0003723,GO:0004674,GO:0005515,GO:0005524,GO:0005759,GO:0006468,GO:0033867,GO:0043484,GO:0044528,GO:0097190" RNA binding|protein serine/threonine kinase activity|protein binding|ATP binding|mitochondrial matrix|protein phosphorylation|Fas-activated serine/threonine kinase activity|regulation of RNA splicing|regulation of mitochondrial mRNA stability|apoptotic signaling pathway FASTKD1 367.3522019 393.8029157 340.9014881 0.865665221 -0.208118896 0.642719328 1 3.165829909 2.858600578 79675 FAST kinase domains 1 "GO:0000959,GO:0003723,GO:0005515,GO:0005739,GO:0044528" mitochondrial RNA metabolic process|RNA binding|protein binding|mitochondrion|regulation of mitochondrial mRNA stability FASTKD2 528.2633009 583.5996818 472.9269199 0.810361854 -0.303361831 0.452606295 1 4.465518215 3.774563919 22868 FAST kinase domains 2 "GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0019843,GO:0035770,GO:0042645,GO:0044528,GO:0070131,GO:0140208,GO:1902775" RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|rRNA binding|ribonucleoprotein granule|mitochondrial nucleoid|regulation of mitochondrial mRNA stability|positive regulation of mitochondrial translation|apoptotic process in response to mitochondrial fragmentation|mitochondrial large ribosomal subunit assembly FASTKD3 297.4781004 331.8906017 263.0655992 0.792627444 -0.335285175 0.481270083 1 6.914474757 5.716684578 79072 FAST kinase domains 3 "GO:0003723,GO:0005515,GO:0005654,GO:0005739,GO:0033617,GO:0044528,GO:0070131" RNA binding|protein binding|nucleoplasm|mitochondrion|mitochondrial cytochrome c oxidase assembly|regulation of mitochondrial mRNA stability|positive regulation of mitochondrial translation FASTKD5 957.073041 1002.776497 911.3695853 0.908846177 -0.137891957 0.699481923 1 17.87019422 16.94086521 60493 FAST kinase domains 5 "GO:0000963,GO:0003723,GO:0005515,GO:0005739,GO:0006397,GO:0019843,GO:0035770,GO:0042645,GO:0044528" mitochondrial RNA processing|RNA binding|protein binding|mitochondrion|mRNA processing|rRNA binding|ribonucleoprotein granule|mitochondrial nucleoid|regulation of mitochondrial mRNA stability FAT1 7030.743232 7705.545712 6355.940751 0.824852773 -0.277791457 0.396629148 1 25.74265876 22.14857392 2195 FAT atypical cadherin 1 "GO:0005509,GO:0005515,GO:0005634,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0007015,GO:0007155,GO:0007156,GO:0007163,GO:0007267,GO:0009653,GO:0016477,GO:0048471,GO:0070062,GO:0098609" calcium ion binding|protein binding|nucleus|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|actin filament organization|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|establishment or maintenance of cell polarity|cell-cell signaling|anatomical structure morphogenesis|cell migration|perinuclear region of cytoplasm|extracellular exosome|cell-cell adhesion FAT4 373.0586692 346.0999852 400.0173531 1.155785525 0.208873707 0.639953835 1 1.019824487 1.229471926 79633 FAT atypical cadherin 4 "GO:0001658,GO:0003007,GO:0005509,GO:0005515,GO:0005886,GO:0007009,GO:0007156,GO:0007157,GO:0007219,GO:0008543,GO:0016021,GO:0021987,GO:0022008,GO:0035329,GO:0043931,GO:0045177,GO:0048565,GO:0060122,GO:0070062,GO:0072137,GO:0072307,GO:0098609" branching involved in ureteric bud morphogenesis|heart morphogenesis|calcium ion binding|protein binding|plasma membrane|plasma membrane organization|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|Notch signaling pathway|fibroblast growth factor receptor signaling pathway|integral component of membrane|cerebral cortex development|neurogenesis|hippo signaling|ossification involved in bone maturation|apical part of cell|digestive tract development|inner ear receptor cell stereocilium organization|extracellular exosome|condensed mesenchymal cell proliferation|regulation of metanephric nephron tubule epithelial cell differentiation|cell-cell adhesion hsa04392 Hippo signaling pathway - multiple species FAU 4165.317175 4318.637645 4011.996704 0.928995909 -0.106255852 0.739480252 1 432.2603982 418.8660684 2197 FAU ubiquitin like and ribosomal protein S30 fusion "GO:0003723,GO:0005575,GO:0008150" RNA binding|cellular_component|biological_process "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 FAXC 112.9854818 79.16656553 146.8043981 1.854373713 0.89093202 0.172196219 1 0.340134651 0.657906336 84553 "failed axon connections homolog, metaxin like GST domain containing" "GO:0005737,GO:0016021" cytoplasm|integral component of membrane FAXDC2 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.030695027 0.020720408 10826 fatty acid hydroxylase domain containing 2 "GO:0000254,GO:0001934,GO:0005506,GO:0005515,GO:0005737,GO:0005789,GO:0016020,GO:0016021,GO:0016126,GO:0016491,GO:0045654,GO:0055114" C-4 methylsterol oxidase activity|positive regulation of protein phosphorylation|iron ion binding|protein binding|cytoplasm|endoplasmic reticulum membrane|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity|positive regulation of megakaryocyte differentiation|oxidation-reduction process FBF1 259.1176145 268.9633316 249.2718974 0.926787662 -0.109689256 0.831440881 1 2.911315217 2.81439729 85302 Fas binding factor 1 "GO:0000922,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0036064,GO:0043296,GO:0043297,GO:0045095,GO:0060271,GO:0090162,GO:0097539,GO:0097711" spindle pole|protein binding|centrosome|centriole|cytosol|ciliary basal body|apical junction complex|apical junction assembly|keratin filament|cilium assembly|establishment of epithelial cell polarity|ciliary transition fiber|ciliary basal body-plasma membrane docking FBH1 1956.489687 1734.55975 2178.419625 1.255891949 0.328712347 0.308615831 1 16.5161369 21.63598542 84893 F-box DNA helicase 1 "GO:0000724,GO:0000725,GO:0000737,GO:0000785,GO:0001934,GO:0003678,GO:0003690,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0006974,GO:0008219,GO:0015616,GO:0016567,GO:0019005,GO:0031297,GO:0032508,GO:0035562,GO:0043138,GO:0048478,GO:0072429,GO:1902231,GO:2000042" "double-strand break repair via homologous recombination|recombinational repair|DNA catabolic process, endonucleolytic|chromatin|positive regulation of protein phosphorylation|DNA helicase activity|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|cellular response to DNA damage stimulus|cell death|DNA translocase activity|protein ubiquitination|SCF ubiquitin ligase complex|replication fork processing|DNA duplex unwinding|negative regulation of chromatin binding|3'-5' DNA helicase activity|replication fork protection|response to intra-S DNA damage checkpoint signaling|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of double-strand break repair via homologous recombination" FBL 2688.513441 2810.413076 2566.613805 0.913251446 -0.130915962 0.681665453 1 128.0013559 121.9328902 2091 fibrillarin "GO:0000494,GO:0001094,GO:0001649,GO:0001650,GO:0001651,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0006364,GO:0008649,GO:0015030,GO:0016020,GO:0031167,GO:0031428,GO:0032040,GO:0048254,GO:0051117,GO:0070062,GO:1990258,GO:1990259" box C/D RNA 3'-end processing|TFIID-class transcription factor complex binding|osteoblast differentiation|fibrillar center|dense fibrillar component|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|rRNA processing|rRNA methyltransferase activity|Cajal body|membrane|rRNA methylation|box C/D RNP complex|small-subunit processome|snoRNA localization|ATPase binding|extracellular exosome|histone glutamine methylation|histone-glutamine methyltransferase activity hsa03008 Ribosome biogenesis in eukaryotes FBLIM1 2028.377371 2001.49317 2055.261573 1.026864145 0.038245325 0.906906884 1 20.28182637 21.72380922 54751 filamin binding LIM protein 1 "GO:0001650,GO:0001725,GO:0005515,GO:0005737,GO:0005829,GO:0005925,GO:0008360,GO:0030054,GO:0031005,GO:0033623,GO:0034329,GO:0046872,GO:0071944,GO:0098609" fibrillar center|stress fiber|protein binding|cytoplasm|cytosol|focal adhesion|regulation of cell shape|cell junction|filamin binding|regulation of integrin activation|cell junction assembly|metal ion binding|cell periphery|cell-cell adhesion FBLN1 3498.052165 3426.491349 3569.612981 1.04176915 0.05903562 0.853509899 1 36.00408691 39.12363726 2192 fibulin 1 "GO:0001933,GO:0001968,GO:0005201,GO:0005509,GO:0005576,GO:0005615,GO:0007162,GO:0007229,GO:0008022,GO:0010952,GO:0016032,GO:0016504,GO:0030198,GO:0031012,GO:0042802,GO:0044877,GO:0062023,GO:0070051,GO:0070062,GO:0070373,GO:0071953,GO:0072378,GO:1900025,GO:2000146,GO:2000647" "negative regulation of protein phosphorylation|fibronectin binding|extracellular matrix structural constituent|calcium ion binding|extracellular region|extracellular space|negative regulation of cell adhesion|integrin-mediated signaling pathway|protein C-terminus binding|positive regulation of peptidase activity|viral process|peptidase activator activity|extracellular matrix organization|extracellular matrix|identical protein binding|protein-containing complex binding|collagen-containing extracellular matrix|fibrinogen binding|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|elastic fiber|blood coagulation, fibrin clot formation|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of cell motility|negative regulation of stem cell proliferation" FBLN5 137.498326 71.04691779 203.9497342 2.870634513 1.521369659 0.014134312 0.527758864 1.074112163 3.216203101 10516 fibulin 5 "GO:0005178,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0007160,GO:0008022,GO:0030023,GO:0030198,GO:0031012,GO:0034394,GO:0042803,GO:0046903,GO:0048251,GO:0062023,GO:0070062,GO:0071953,GO:2000121" integrin binding|calcium ion binding|protein binding|extracellular region|extracellular space|cell-matrix adhesion|protein C-terminus binding|extracellular matrix constituent conferring elasticity|extracellular matrix organization|extracellular matrix|protein localization to cell surface|protein homodimerization activity|secretion|elastic fiber assembly|collagen-containing extracellular matrix|extracellular exosome|elastic fiber|regulation of removal of superoxide radicals FBLN7 119.847198 144.1237475 95.57064841 0.663115205 -0.592668559 0.354670155 1 0.975198313 0.6745247 129804 fibulin 7 "GO:0005509,GO:0005615,GO:0005925,GO:0007155,GO:0008201,GO:0031012,GO:0043395,GO:0110151" calcium ion binding|extracellular space|focal adhesion|cell adhesion|heparin binding|extracellular matrix|heparan sulfate proteoglycan binding|positive regulation of biomineralization FBN1 1060.664614 1315.382935 805.9462927 0.612708491 -0.706727251 0.043306549 0.94601832 5.73860843 3.667553184 2200 fibrillin 1 "GO:0001501,GO:0001527,GO:0001656,GO:0005178,GO:0005179,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005788,GO:0007165,GO:0007507,GO:0008201,GO:0009653,GO:0030023,GO:0030198,GO:0031012,GO:0033627,GO:0035582,GO:0035583,GO:0042802,GO:0043010,GO:0043687,GO:0044267,GO:0044877,GO:0045671,GO:0048048,GO:0048050,GO:0062023,GO:0071560,GO:1990314,GO:2001205" skeletal system development|microfibril|metanephros development|integrin binding|hormone activity|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|basement membrane|extracellular space|endoplasmic reticulum lumen|signal transduction|heart development|heparin binding|anatomical structure morphogenesis|extracellular matrix constituent conferring elasticity|extracellular matrix organization|extracellular matrix|cell adhesion mediated by integrin|sequestering of BMP in extracellular matrix|sequestering of TGFbeta in extracellular matrix|identical protein binding|camera-type eye development|post-translational protein modification|cellular protein metabolic process|protein-containing complex binding|negative regulation of osteoclast differentiation|embryonic eye morphogenesis|post-embryonic eye morphogenesis|collagen-containing extracellular matrix|cellular response to transforming growth factor beta stimulus|cellular response to insulin-like growth factor stimulus|negative regulation of osteoclast development hsa04350 TGF-beta signaling pathway FBRS 1674.66497 1664.527788 1684.802152 1.01218025 0.017466229 0.959403756 1 16.22449199 17.12950826 64319 fibrosin FBRSL1 734.9676685 670.8858951 799.0494418 1.191036282 0.252217361 0.500805906 1 3.85500384 4.789230459 57666 fibrosin like 1 GO:0003723 RNA binding FBXL12 336.2624329 322.7559979 349.7688679 1.083694401 0.115957978 0.804695306 1 6.699365853 7.572799433 54850 F-box and leucine rich repeat protein 12 "GO:0000086,GO:0000209,GO:0005515,GO:0005634,GO:0005829,GO:0019005,GO:0031146,GO:0043153,GO:0043687,GO:0051726" G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|nucleus|cytosol|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|entrainment of circadian clock by photoperiod|post-translational protein modification|regulation of cell cycle FBXL13 73.91635798 102.5105528 45.32216316 0.442121927 -1.177483808 0.117746905 1 0.796410165 0.367277885 222235 F-box and leucine rich repeat protein 13 "GO:0000209,GO:0005829,GO:0005856,GO:0019005,GO:0031146,GO:0031514,GO:0043687" protein polyubiquitination|cytosol|cytoskeleton|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|motile cilium|post-translational protein modification FBXL14 426.8904296 523.7172797 330.0635795 0.630232365 -0.666044251 0.118191542 1 2.929258161 1.925636371 144699 F-box and leucine rich repeat protein 14 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006511,GO:0019005,GO:0031146,GO:0043687" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL15 505.7143045 490.2237327 521.2048764 1.063197968 0.088410252 0.832345328 1 11.66734147 12.93903764 79176 F-box and leucine rich repeat protein 15 "GO:0000086,GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0009953,GO:0016567,GO:0019005,GO:0030282,GO:0030513,GO:0031146,GO:0043687" G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|cytoplasm|cytosol|dorsal/ventral pattern formation|protein ubiquitination|SCF ubiquitin ligase complex|bone mineralization|positive regulation of BMP signaling pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL16 1.970528833 0 3.941057666 Inf Inf 0.26888406 1 0 0.048519845 146330 F-box and leucine rich repeat protein 16 "GO:0000209,GO:0005829,GO:0019005,GO:0031146,GO:0043687" protein polyubiquitination|cytosol|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL17 665.8170506 523.7172797 807.9168216 1.542658325 0.625418563 0.101865179 1 1.402370342 2.256567846 64839 F-box and leucine rich repeat protein 17 "GO:0000086,GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006515,GO:0007399,GO:0008589,GO:0014033,GO:0016567,GO:0019005,GO:0031146,GO:0043153,GO:0043161,GO:0051726" G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein quality control for misfolded or incompletely synthesized proteins|nervous system development|regulation of smoothened signaling pathway|neural crest cell differentiation|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|entrainment of circadian clock by photoperiod|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of cell cycle FBXL18 1351.047671 1330.607275 1371.488068 1.03072341 0.043657244 0.898765569 1 6.934612508 7.455559979 80028 F-box and leucine rich repeat protein 18 "GO:0000209,GO:0005829,GO:0019005,GO:0031146,GO:0043687" protein polyubiquitination|cytosol|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL19 1232.637792 1318.427803 1146.847781 0.869860131 -0.201144654 0.555608889 1 13.39224169 12.15118503 54620 F-box and leucine rich repeat protein 19 "GO:0000209,GO:0003712,GO:0005515,GO:0005829,GO:0006357,GO:0006482,GO:0008270,GO:0016577,GO:0019005,GO:0032452,GO:0043161,GO:0043687,GO:0045322" protein polyubiquitination|transcription coregulator activity|protein binding|cytosol|regulation of transcription by RNA polymerase II|protein demethylation|zinc ion binding|histone demethylation|SCF ubiquitin ligase complex|histone demethylase activity|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|unmethylated CpG binding FBXL2 285.8709331 245.6193443 326.1225219 1.327755852 0.408989888 0.395503308 1 2.897683042 4.013146678 25827 F-box and leucine rich repeat protein 2 "GO:0005515,GO:0005516,GO:0005737,GO:0006464,GO:0006508,GO:0006513,GO:0010506,GO:0014066,GO:0016020,GO:0016032,GO:0016567,GO:0019005,GO:0019903,GO:0031146,GO:0036312,GO:0044830" protein binding|calmodulin binding|cytoplasm|cellular protein modification process|proteolysis|protein monoubiquitination|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|membrane|viral process|protein ubiquitination|SCF ubiquitin ligase complex|protein phosphatase binding|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|phosphatidylinositol 3-kinase regulatory subunit binding|modulation by host of viral RNA genome replication FBXL20 690.0342171 663.7812033 716.2872308 1.079101408 0.109830447 0.774711284 1 3.137194501 3.531178193 84961 F-box and leucine rich repeat protein 20 "GO:0000209,GO:0005515,GO:0005829,GO:0019005,GO:0031146,GO:0043687" protein polyubiquitination|protein binding|cytosol|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL22 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.06552446 0.049760673 283807 F-box and leucine rich repeat protein 22 "GO:0000086,GO:0000209,GO:0005515,GO:0005634,GO:0005730,GO:0005829,GO:0019005,GO:0030018,GO:0031146,GO:0043153,GO:0043161,GO:0043687,GO:0051726,GO:0061630" G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|nucleus|nucleolus|cytosol|SCF ubiquitin ligase complex|Z disc|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|entrainment of circadian clock by photoperiod|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|regulation of cell cycle|ubiquitin protein ligase activity FBXL3 692.2422783 680.0204988 704.4640578 1.035945327 0.050947865 0.896635854 1 8.908597852 9.626360463 26224 F-box and leucine rich repeat protein 3 "GO:0000086,GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005829,GO:0016567,GO:0016604,GO:0019005,GO:0031146,GO:0031648,GO:0042752,GO:0043153,GO:0043687,GO:0048511,GO:0051726" G2/M transition of mitotic cell cycle|ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|cytosol|protein ubiquitination|nuclear body|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein destabilization|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|post-translational protein modification|rhythmic process|regulation of cell cycle hsa04710 Circadian rhythm FBXL4 351.6379518 329.8606897 373.4152139 1.132039147 0.178923849 0.694931346 1 2.0257403 2.391999824 26235 F-box and leucine rich repeat protein 4 "GO:0000151,GO:0000209,GO:0005515,GO:0005758,GO:0005829,GO:0006511,GO:0016607,GO:0019005,GO:0031146,GO:0043687" ubiquitin ligase complex|protein polyubiquitination|protein binding|mitochondrial intermembrane space|cytosol|ubiquitin-dependent protein catabolic process|nuclear speck|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL5 1056.070588 900.2659439 1211.875232 1.346130264 0.428818025 0.219523728 1 10.00335544 14.04587239 26234 F-box and leucine rich repeat protein 5 "GO:0000151,GO:0000209,GO:0004842,GO:0005506,GO:0005515,GO:0005829,GO:0006879,GO:0016567,GO:0019005,GO:0031146,GO:0043687,GO:0048471,GO:0055072,GO:1903364" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|iron ion binding|protein binding|cytosol|cellular iron ion homeostasis|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|perinuclear region of cytoplasm|iron ion homeostasis|positive regulation of cellular protein catabolic process FBXL6 688.3578822 717.5738696 659.1418947 0.918570091 -0.122538285 0.749115996 1 20.8266963 19.95485675 26233 F-box and leucine rich repeat protein 6 "GO:0000086,GO:0004842,GO:0005634,GO:0005829,GO:0006508,GO:0016567,GO:0019005,GO:0031146,GO:0043153,GO:0051726" G2/M transition of mitotic cell cycle|ubiquitin-protein transferase activity|nucleus|cytosol|proteolysis|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|entrainment of circadian clock by photoperiod|regulation of cell cycle FBXL7 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.005308679 0.016126096 23194 F-box and leucine rich repeat protein 7 "GO:0000086,GO:0000151,GO:0000209,GO:0000278,GO:0005515,GO:0005813,GO:0005829,GO:0006511,GO:0010265,GO:0010972,GO:0016567,GO:0019005,GO:0031146,GO:0043687,GO:0051301" G2/M transition of mitotic cell cycle|ubiquitin ligase complex|protein polyubiquitination|mitotic cell cycle|protein binding|centrosome|cytosol|ubiquitin-dependent protein catabolic process|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|cell division FBXL8 43.0492756 46.68797455 39.41057666 0.844126931 -0.244468142 0.803823244 1 1.450663316 1.277292361 55336 F-box and leucine rich repeat protein 8 "GO:0000086,GO:0000209,GO:0005515,GO:0005634,GO:0005829,GO:0019005,GO:0031146,GO:0043153,GO:0043687,GO:0051726" G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|nucleus|cytosol|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|entrainment of circadian clock by photoperiod|post-translational protein modification|regulation of cell cycle FBXO10 452.4330756 518.6424998 386.2236513 0.74468184 -0.425303918 0.31073678 1 4.668932271 3.626638495 26267 F-box protein 10 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006511,GO:0006915,GO:0016567,GO:0042981,GO:0043687" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|protein ubiquitination|regulation of apoptotic process|post-translational protein modification FBXO11 933.7196512 888.0864723 979.35283 1.102767423 0.141128554 0.694072161 1 10.67357543 12.27749543 80204 F-box protein 11 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0006464,GO:0006511,GO:0007605,GO:0008270,GO:0016274,GO:0016567,GO:0035246,GO:0042981,GO:0043687" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|sensory perception of sound|zinc ion binding|protein-arginine N-methyltransferase activity|protein ubiquitination|peptidyl-arginine N-methylation|regulation of apoptotic process|post-translational protein modification FBXO15 9.597544372 16.23929549 2.95579325 0.182014869 -2.457871781 0.104356556 1 0.070211971 0.013330117 201456 F-box protein 15 "GO:0000209,GO:0005515,GO:0005829,GO:0043687" protein polyubiquitination|protein binding|cytosol|post-translational protein modification FBXO16 44.06423157 48.71788648 39.41057666 0.808954975 -0.305868687 0.746371813 1 1.967614899 1.660276354 157574 F-box protein 16 GO:0005515 protein binding FBXO17 456.536199 361.3243247 551.7480733 1.527016133 0.610715305 0.144606961 1 7.843893001 12.4937041 115290 F-box protein 17 "GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0006516,GO:0019005,GO:0030433,GO:0031146,GO:0043687,GO:0061630" protein polyubiquitination|protein binding|cytoplasm|cytosol|glycoprotein catabolic process|SCF ubiquitin ligase complex|ubiquitin-dependent ERAD pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin protein ligase activity FBXO2 391.2684935 378.5785762 403.9584108 1.067039807 0.093613998 0.835175801 1 14.89795597 16.58147795 26232 F-box protein 2 "GO:0000209,GO:0001540,GO:0004842,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0006464,GO:0006508,GO:0006516,GO:0008285,GO:0016567,GO:0019005,GO:0030246,GO:0030433,GO:0031090,GO:0031146,GO:0031396,GO:0043197,GO:0043687,GO:0061630" protein polyubiquitination|amyloid-beta binding|ubiquitin-protein transferase activity|protein binding|cytoplasm|endoplasmic reticulum|cytosol|cellular protein modification process|proteolysis|glycoprotein catabolic process|negative regulation of cell population proliferation|protein ubiquitination|SCF ubiquitin ligase complex|carbohydrate binding|ubiquitin-dependent ERAD pathway|organelle membrane|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of protein ubiquitination|dendritic spine|post-translational protein modification|ubiquitin protein ligase activity "hsa04120,hsa04141" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum FBXO21 1152.189046 1139.795552 1164.58254 1.021746872 0.031037827 0.930729146 1 9.609892421 10.24183494 23014 F-box protein 21 "GO:0000151,GO:0000209,GO:0003677,GO:0004842,GO:0005829,GO:0006511,GO:0043687" ubiquitin ligase complex|protein polyubiquitination|DNA binding|ubiquitin-protein transferase activity|cytosol|ubiquitin-dependent protein catabolic process|post-translational protein modification FBXO22 1077.512832 1019.015792 1136.009872 1.114810861 0.156798962 0.653577426 1 21.63015717 25.15224738 26263 F-box protein 22 "GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0006464,GO:0006511,GO:0030018,GO:0032436,GO:0043687,GO:0048742" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|Z disc|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|regulation of skeletal muscle fiber development hsa05132 Salmonella infection FBXO24 12.9420494 9.134603715 16.74949508 1.833631278 0.874703559 0.515481793 1 0.088712455 0.169672921 26261 F-box protein 24 "GO:0000151,GO:0004842,GO:0005515,GO:0016567" ubiquitin ligase complex|ubiquitin-protein transferase activity|protein binding|protein ubiquitination FBXO25 179.5150783 148.1835714 210.8465851 1.422874231 0.508808146 0.363521039 1 4.098839503 6.083357746 26260 F-box protein 25 "GO:0000151,GO:0003779,GO:0004842,GO:0005634,GO:0005730,GO:0016567,GO:0019005" ubiquitin ligase complex|actin binding|ubiquitin-protein transferase activity|nucleus|nucleolus|protein ubiquitination|SCF ubiquitin ligase complex hsa04068 FoxO signaling pathway FBXO27 734.8813154 631.3026123 838.4600185 1.328142799 0.40941027 0.273626657 1 11.41086731 15.80808844 126433 F-box protein 27 "GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0006516,GO:0019005,GO:0030433,GO:0031146,GO:0043687,GO:0061630" protein polyubiquitination|protein binding|cytoplasm|cytosol|glycoprotein catabolic process|SCF ubiquitin ligase complex|ubiquitin-dependent ERAD pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin protein ligase activity FBXO28 1188.18757 1243.321061 1133.054079 0.911312544 -0.133982169 0.697091034 1 11.60306349 11.02950309 23219 F-box protein 28 "GO:0000209,GO:0000776,GO:0000777,GO:0005515,GO:0042802" protein polyubiquitination|kinetochore|condensed chromosome kinetochore|protein binding|identical protein binding FBXO3 522.1520383 468.9096574 575.3944193 1.227090145 0.295241236 0.466231317 1 4.835801249 6.189575159 26273 F-box protein 3 "GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0006508,GO:0016567" ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|proteolysis|protein ubiquitination FBXO30 540.8045143 565.3304744 516.2785543 0.913233193 -0.130944797 0.747022796 1 2.021177055 1.925315811 84085 F-box protein 30 "GO:0000209,GO:0005829,GO:0008270,GO:0043687,GO:0061630" protein polyubiquitination|cytosol|zinc ion binding|post-translational protein modification|ubiquitin protein ligase activity FBXO31 603.2770085 592.7342855 613.8197315 1.035573184 0.050429513 0.901378772 1 4.918070203 5.312408337 79791 F-box protein 31 "GO:0000209,GO:0005515,GO:0005813,GO:0005829,GO:0006974,GO:0019005,GO:0030332,GO:0031145,GO:0031146,GO:0031571,GO:0043025,GO:0043687,GO:0050775,GO:2001224" protein polyubiquitination|protein binding|centrosome|cytosol|cellular response to DNA damage stimulus|SCF ubiquitin ligase complex|cyclin binding|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic G1 DNA damage checkpoint|neuronal cell body|post-translational protein modification|positive regulation of dendrite morphogenesis|positive regulation of neuron migration FBXO32 413.7702309 502.4032043 325.1372575 0.64716398 -0.627796782 0.144167 1 3.689277936 2.490414531 114907 F-box protein 32 "GO:0000209,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0014894,GO:0016567,GO:0019005,GO:0030018,GO:0043687,GO:0071549" protein polyubiquitination|protein binding|nucleoplasm|cytoplasm|cytosol|response to denervation involved in regulation of muscle adaptation|protein ubiquitination|SCF ubiquitin ligase complex|Z disc|post-translational protein modification|cellular response to dexamethasone stimulus hsa04068 FoxO signaling pathway FBXO33 515.0621923 455.7152298 574.4091548 1.260456349 0.333946157 0.411088136 1 4.482495382 5.89336841 254170 F-box protein 33 "GO:0005515,GO:0016567,GO:0019005,GO:0031146" protein binding|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process FBXO34 838.6228299 752.0823726 925.1632871 1.230135582 0.298817334 0.412135822 1 6.409274606 8.223899415 55030 F-box protein 34 GO:0005515 protein binding FBXO36 51.0798487 56.83753423 45.32216316 0.797398476 -0.326627247 0.71287215 1 0.770508725 0.64086845 130888 F-box protein 36 FBXO38 1345.505991 1187.498483 1503.5135 1.266118249 0.340412151 0.311630553 1 10.61090489 14.013371 81545 F-box protein 38 "GO:0002250,GO:0002842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0010976,GO:0019005,GO:0031146,GO:0070936" adaptive immune response|positive regulation of T cell mediated immune response to tumor cell|protein binding|nucleus|cytoplasm|cytosol|positive regulation of neuron projection development|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination FBXO4 248.6832635 262.8735958 234.4929311 0.892036838 -0.164824806 0.748325785 1 1.251633004 1.164597157 26272 F-box protein 4 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0007568,GO:0010608,GO:0016567,GO:0019005,GO:0019725,GO:0031146,GO:0031398,GO:0031647,GO:0031648,GO:0032212,GO:0035726,GO:0042803,GO:0043687,GO:0048147,GO:0061630,GO:0071479,GO:1900181,GO:1902916,GO:2000001" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|aging|posttranscriptional regulation of gene expression|protein ubiquitination|SCF ubiquitin ligase complex|cellular homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|regulation of protein stability|protein destabilization|positive regulation of telomere maintenance via telomerase|common myeloid progenitor cell proliferation|protein homodimerization activity|post-translational protein modification|negative regulation of fibroblast proliferation|ubiquitin protein ligase activity|cellular response to ionizing radiation|negative regulation of protein localization to nucleus|positive regulation of protein polyubiquitination|regulation of DNA damage checkpoint hsa04120 Ubiquitin mediated proteolysis FBXO41 925.8254117 853.5779694 998.072854 1.169281413 0.225622187 0.528555637 1 4.373364988 5.333971607 150726 F-box protein 41 "GO:0000209,GO:0005829,GO:0043687" protein polyubiquitination|cytosol|post-translational protein modification FBXO42 540.6627375 656.6765115 424.6489635 0.646663854 -0.628912124 0.116924024 1 5.215359682 3.517861856 54455 F-box protein 42 GO:0005515 protein binding FBXO43 228.2829453 181.6771183 274.8887722 1.513062155 0.597471253 0.247758426 1 2.911805419 4.595524106 286151 F-box protein 43 "GO:0005515,GO:0005634,GO:0007088,GO:0016567,GO:0045835,GO:0046872,GO:0051321" protein binding|nucleus|regulation of mitotic nuclear division|protein ubiquitination|negative regulation of meiotic nuclear division|metal ion binding|meiotic cell cycle hsa04114 Oocyte meiosis FBXO44 451.275105 439.4759343 463.0742758 1.05369655 0.075459451 0.862050277 1 8.974961974 9.864250783 93611 F-box protein 44 "GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0006516,GO:0010498,GO:0019005,GO:0030433,GO:0031146,GO:0043687,GO:0061630" protein polyubiquitination|protein binding|cytoplasm|cytosol|glycoprotein catabolic process|proteasomal protein catabolic process|SCF ubiquitin ligase complex|ubiquitin-dependent ERAD pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin protein ligase activity FBXO45 744.6164311 791.6656553 697.5672069 0.88113865 -0.182559045 0.625973077 1 6.76481738 6.217506648 200933 F-box protein 45 "GO:0001764,GO:0005515,GO:0006511,GO:0006974,GO:0014069,GO:0016567,GO:0019005,GO:0021799,GO:0021800,GO:0021957,GO:0021960,GO:0042734,GO:0042995,GO:0043161,GO:0045202,GO:0045211,GO:0060386,GO:0098978,GO:0099523,GO:0099524" neuron migration|protein binding|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|postsynaptic density|protein ubiquitination|SCF ubiquitin ligase complex|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration|corticospinal tract morphogenesis|anterior commissure morphogenesis|presynaptic membrane|cell projection|proteasome-mediated ubiquitin-dependent protein catabolic process|synapse|postsynaptic membrane|synapse assembly involved in innervation|glutamatergic synapse|presynaptic cytosol|postsynaptic cytosol FBXO46 379.282017 367.4140606 391.1499734 1.064602625 0.090315029 0.842718574 1 4.935868968 5.481091908 23403 F-box protein 46 GO:0005515 protein binding FBXO48 69.94833037 66.98709391 72.90956682 1.088412149 0.122224965 0.890598714 1 0.591364823 0.671374432 554251 F-box protein 48 "GO:0005515,GO:0019005,GO:0031146" protein binding|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process FBXO5 556.0370187 495.2985126 616.7755248 1.2452602 0.316447228 0.427445378 1 10.45213431 13.57628728 26271 F-box protein 5 "GO:0000083,GO:0001556,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0006275,GO:0007057,GO:0007088,GO:0007346,GO:0008284,GO:0010971,GO:0010997,GO:0016050,GO:0016567,GO:0019901,GO:0031145,GO:0032876,GO:0045669,GO:0045835,GO:0045841,GO:0046785,GO:0046872,GO:0051301,GO:0051444,GO:0070169,GO:0072687,GO:1901990,GO:1904667,GO:1905322,GO:1990948,GO:2000773,GO:2001021" regulation of transcription involved in G1/S transition of mitotic cell cycle|oocyte maturation|protein binding|nucleus|nucleoplasm|cytoplasm|spindle|cytosol|regulation of DNA replication|spindle assembly involved in female meiosis I|regulation of mitotic nuclear division|regulation of mitotic cell cycle|positive regulation of cell population proliferation|positive regulation of G2/M transition of mitotic cell cycle|anaphase-promoting complex binding|vesicle organization|protein ubiquitination|protein kinase binding|anaphase-promoting complex-dependent catabolic process|negative regulation of DNA endoreduplication|positive regulation of osteoblast differentiation|negative regulation of meiotic nuclear division|negative regulation of mitotic metaphase/anaphase transition|microtubule polymerization|metal ion binding|cell division|negative regulation of ubiquitin-protein transferase activity|positive regulation of biomineral tissue development|meiotic spindle|regulation of mitotic cell cycle phase transition|negative regulation of ubiquitin protein ligase activity|positive regulation of mesenchymal stem cell migration|ubiquitin ligase inhibitor activity|negative regulation of cellular senescence|negative regulation of response to DNA damage stimulus hsa04114 Oocyte meiosis FBXO6 113.6832333 126.869496 100.4969705 0.792128712 -0.336193224 0.610926433 1 3.332724277 2.753664781 26270 F-box protein 6 "GO:0000077,GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0006281,GO:0006508,GO:0006516,GO:0006986,GO:0019005,GO:0030246,GO:0030433,GO:0031146,GO:0043687,GO:0044322,GO:0061630" DNA damage checkpoint|protein polyubiquitination|protein binding|cytoplasm|cytosol|DNA repair|proteolysis|glycoprotein catabolic process|response to unfolded protein|SCF ubiquitin ligase complex|carbohydrate binding|ubiquitin-dependent ERAD pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|endoplasmic reticulum quality control compartment|ubiquitin protein ligase activity hsa04141 Protein processing in endoplasmic reticulum FBXO7 2028.045321 2046.151232 2009.93941 0.98230247 -0.025760768 0.937791994 1 44.66825066 45.76780774 25793 F-box protein 7 "GO:0000151,GO:0000209,GO:0000422,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006511,GO:0006626,GO:0010975,GO:0016567,GO:0019005,GO:0019901,GO:0031625,GO:0031647,GO:0032991,GO:0040012,GO:0043130,GO:0043687,GO:0045620,GO:0045736,GO:0046982,GO:0097409,GO:0097414,GO:0097462,GO:1903204,GO:1903599,GO:1990037,GO:1990038,GO:1990756,GO:2000134" ubiquitin ligase complex|protein polyubiquitination|autophagy of mitochondrion|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|ubiquitin-dependent protein catabolic process|protein targeting to mitochondrion|regulation of neuron projection development|protein ubiquitination|SCF ubiquitin ligase complex|protein kinase binding|ubiquitin protein ligase binding|regulation of protein stability|protein-containing complex|regulation of locomotion|ubiquitin binding|post-translational protein modification|negative regulation of lymphocyte differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|protein heterodimerization activity|glial cytoplasmic inclusion|classical Lewy body|Lewy neurite|negative regulation of oxidative stress-induced neuron death|positive regulation of autophagy of mitochondrion|Lewy body core|Lewy body corona|ubiquitin ligase-substrate adaptor activity|negative regulation of G1/S transition of mitotic cell cycle FBXO8 224.0895094 164.4228669 283.756152 1.725770614 0.787240717 0.130349031 1 3.992060479 7.186147242 26269 F-box protein 8 "GO:0000151,GO:0005085,GO:0006511,GO:0032012,GO:0050790" ubiquitin ligase complex|guanyl-nucleotide exchange factor activity|ubiquitin-dependent protein catabolic process|regulation of ARF protein signal transduction|regulation of catalytic activity FBXO9 763.2473804 785.5759195 740.9188412 0.943153708 -0.084435186 0.822811759 1 7.614669661 7.491166911 26268 F-box protein 9 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0016567,GO:0019005,GO:0031146,GO:0032006,GO:0043687,GO:0045087,GO:0045444" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of TOR signaling|post-translational protein modification|innate immune response|fat cell differentiation FBXW11 2170.611746 2025.852113 2315.371379 1.14291234 0.192714755 0.548209203 1 20.4142982 24.33679063 23291 F-box and WD repeat domain containing 11 "GO:0000086,GO:0000132,GO:0000151,GO:0000209,GO:0000776,GO:0002223,GO:0004842,GO:0005515,GO:0005634,GO:0005635,GO:0005813,GO:0005829,GO:0005875,GO:0005881,GO:0006470,GO:0007097,GO:0007281,GO:0008090,GO:0016032,GO:0016055,GO:0016567,GO:0019005,GO:0031023,GO:0031146,GO:0031648,GO:0038061,GO:0038095,GO:0042753,GO:0043005,GO:0043025,GO:0043161,GO:0043687,GO:0045862,GO:0045892,GO:0045893,GO:0046983,GO:0047496,GO:0048511,GO:0048854,GO:0050852,GO:0051010,GO:0051403,GO:0070498,GO:0070840,GO:1904115,GO:2000574" "G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|ubiquitin ligase complex|protein polyubiquitination|kinetochore|stimulatory C-type lectin receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|nucleus|nuclear envelope|centrosome|cytosol|microtubule associated complex|cytoplasmic microtubule|protein dephosphorylation|nuclear migration|germ cell development|retrograde axonal transport|viral process|Wnt signaling pathway|protein ubiquitination|SCF ubiquitin ligase complex|microtubule organizing center organization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein destabilization|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|positive regulation of circadian rhythm|neuron projection|neuronal cell body|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|positive regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|vesicle transport along microtubule|rhythmic process|brain morphogenesis|T cell receptor signaling pathway|microtubule plus-end binding|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|dynein complex binding|axon cytoplasm|regulation of microtubule motor activity" "hsa04114,hsa04120,hsa04218,hsa04310,hsa04340,hsa04390,hsa04710,hsa05131,hsa05170" Oocyte meiosis|Ubiquitin mediated proteolysis|Cellular senescence|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Circadian rhythm|Shigellosis|Human immunodeficiency virus 1 infection FBXW2 2061.229828 2058.330704 2064.128953 1.002816967 0.00405831 0.991643958 1 11.22506609 11.74157914 26190 F-box and WD repeat domain containing 2 "GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0006464,GO:0006508,GO:0043687" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|cellular protein modification process|proteolysis|post-translational protein modification FBXW4 1363.602493 1144.870332 1582.334653 1.382108181 0.466870544 0.164563186 1 25.59984259 36.90585427 6468 F-box and WD repeat domain containing 4 "GO:0000151,GO:0000209,GO:0005515,GO:0005829,GO:0006511,GO:0016055,GO:0019005,GO:0030326,GO:0031146,GO:0043687" ubiquitin ligase complex|protein polyubiquitination|protein binding|cytosol|ubiquitin-dependent protein catabolic process|Wnt signaling pathway|SCF ubiquitin ligase complex|embryonic limb morphogenesis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXW5 2146.185255 2073.555043 2218.815466 1.070053806 0.097683342 0.761720563 1 46.61262667 52.02656133 54461 F-box and WD repeat domain containing 5 "GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0007088,GO:0010824,GO:0016567,GO:0019005,GO:0019901,GO:0031146,GO:0043161,GO:0043687,GO:0080008" protein polyubiquitination|protein binding|cytoplasm|cytosol|regulation of mitotic nuclear division|regulation of centrosome duplication|protein ubiquitination|SCF ubiquitin ligase complex|protein kinase binding|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex FBXW7 261.8061838 250.6941242 272.9182434 1.088650339 0.122540653 0.810347495 1 2.182326056 2.4781294 55294 F-box and WD repeat domain containing 7 "GO:0000209,GO:0001570,GO:0001944,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0005829,GO:0007062,GO:0007219,GO:0010629,GO:0010868,GO:0010883,GO:0010992,GO:0016032,GO:0016567,GO:0019005,GO:0030324,GO:0030332,GO:0030674,GO:0031146,GO:0031398,GO:0031625,GO:0031648,GO:0032880,GO:0042752,GO:0042802,GO:0043130,GO:0043161,GO:0043687,GO:0045741,GO:0045746,GO:0048471,GO:0048511,GO:0050816,GO:0050821,GO:0051443,GO:0055088,GO:0070374,GO:0090049,GO:0097027,GO:1901800,GO:1902806,GO:1903026,GO:1903146,GO:1903378,GO:1903955,GO:1990452,GO:2000060,GO:2000346,GO:2000639,GO:2001205" protein polyubiquitination|vasculogenesis|vasculature development|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|sister chromatid cohesion|Notch signaling pathway|negative regulation of gene expression|negative regulation of triglyceride biosynthetic process|regulation of lipid storage|ubiquitin recycling|viral process|protein ubiquitination|SCF ubiquitin ligase complex|lung development|cyclin binding|protein-macromolecule adaptor activity|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein destabilization|regulation of protein localization|regulation of circadian rhythm|identical protein binding|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of Notch signaling pathway|perinuclear region of cytoplasm|rhythmic process|phosphothreonine residue binding|protein stabilization|positive regulation of ubiquitin-protein transferase activity|lipid homeostasis|positive regulation of ERK1 and ERK2 cascade|regulation of cell migration involved in sprouting angiogenesis|ubiquitin-protein transferase activator activity|positive regulation of proteasomal protein catabolic process|regulation of cell cycle G1/S phase transition|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|regulation of autophagy of mitochondrion|positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|positive regulation of protein targeting to mitochondrion|Parkin-FBXW7-Cul1 ubiquitin ligase complex|positive regulation of ubiquitin-dependent protein catabolic process|negative regulation of hepatocyte proliferation|negative regulation of SREBP signaling pathway|negative regulation of osteoclast development hsa04120 Ubiquitin mediated proteolysis FBXW8 584.4948799 622.1680086 546.8217512 0.878897249 -0.186233584 0.63800933 1 3.860648709 3.539275099 26259 F-box and WD repeat domain containing 8 "GO:0000209,GO:0004842,GO:0005515,GO:0005794,GO:0005829,GO:0007030,GO:0008283,GO:0016567,GO:0019005,GO:0031467,GO:0043687,GO:0048471,GO:0050775,GO:0060716,GO:1901485,GO:1990393" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|Golgi apparatus|cytosol|Golgi organization|cell population proliferation|protein ubiquitination|SCF ubiquitin ligase complex|Cul7-RING ubiquitin ligase complex|post-translational protein modification|perinuclear region of cytoplasm|positive regulation of dendrite morphogenesis|labyrinthine layer blood vessel development|positive regulation of transcription factor catabolic process|3M complex hsa04120 Ubiquitin mediated proteolysis FBXW9 127.417552 122.8096722 132.0254318 1.075040992 0.104391672 0.879227144 1 3.601549884 4.038595794 84261 F-box and WD repeat domain containing 9 "GO:0000209,GO:0005515,GO:0005829,GO:0030687,GO:0043687" "protein polyubiquitination|protein binding|cytosol|preribosome, large subunit precursor|post-translational protein modification" FCER1G 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.348501283 0.088219769 2207 Fc fragment of IgE receptor Ig "GO:0002223,GO:0002283,GO:0002292,GO:0002431,GO:0005515,GO:0005886,GO:0005887,GO:0007596,GO:0009897,GO:0009986,GO:0010543,GO:0016064,GO:0019767,GO:0019863,GO:0019864,GO:0019886,GO:0030168,GO:0030593,GO:0031623,GO:0032753,GO:0032998,GO:0038094,GO:0038095,GO:0038156,GO:0042590,GO:0042742,GO:0042802,GO:0043312,GO:0045087,GO:0050766,GO:0050900,GO:0070821,GO:0071404,GO:0101003" stimulatory C-type lectin receptor signaling pathway|neutrophil activation involved in immune response|T cell differentiation involved in immune response|Fc receptor mediated stimulatory signaling pathway|protein binding|plasma membrane|integral component of plasma membrane|blood coagulation|external side of plasma membrane|cell surface|regulation of platelet activation|immunoglobulin mediated immune response|IgE receptor activity|IgE binding|IgG binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|platelet activation|neutrophil chemotaxis|receptor internalization|positive regulation of interleukin-4 production|Fc-epsilon receptor I complex|Fc-gamma receptor signaling pathway|Fc-epsilon receptor signaling pathway|interleukin-3-mediated signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I|defense response to bacterium|identical protein binding|neutrophil degranulation|innate immune response|positive regulation of phagocytosis|leukocyte migration|tertiary granule membrane|cellular response to low-density lipoprotein particle stimulus|ficolin-1-rich granule membrane "hsa04071,hsa04072,hsa04611,hsa04625,hsa04650,hsa04664,hsa05152,hsa05310" Sphingolipid signaling pathway|Phospholipase D signaling pathway|Platelet activation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Fc epsilon RI signaling pathway|Tuberculosis|Asthma FCF1 918.7031525 871.8471768 965.5591282 1.107486672 0.147289337 0.682225954 1 29.49631517 34.07392814 51077 FCF1 rRNA-processing protein "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0032040" RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|small-subunit processome hsa03008 Ribosome biogenesis in eukaryotes FCGBP 3.537500113 6.08973581 0.985264417 0.161790995 -2.627796782 0.2971307 1 0.024046752 0.004058137 8857 Fc fragment of IgG binding protein "GO:0005515,GO:0005615,GO:0031012,GO:0070062" protein binding|extracellular space|extracellular matrix|extracellular exosome FCGR2A 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.070843356 0.02869331 2212 Fc fragment of IgG receptor IIa "GO:0004888,GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0007166,GO:0019864,GO:0030667,GO:0038096,GO:0043312,GO:0050776" transmembrane signaling receptor activity|protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|IgG binding|secretory granule membrane|Fc-gamma receptor signaling pathway involved in phagocytosis|neutrophil degranulation|regulation of immune response "hsa04145,hsa04380,hsa04611,hsa04666,hsa05130,hsa05135,hsa05140,hsa05150,hsa05152,hsa05171,hsa05322" Phagosome|Osteoclast differentiation|Platelet activation|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Yersinia infection|Leishmaniasis|Staphylococcus aureus infection|Tuberculosis|Coronavirus disease - COVID-19|Systemic lupus erythematosus FCGRT 457.9789609 426.2815067 489.676415 1.148716065 0.200022243 0.63478736 1 13.22895495 15.85090862 2217 Fc fragment of IgG receptor and transporter "GO:0002416,GO:0005515,GO:0005615,GO:0006955,GO:0009897,GO:0010008,GO:0016021,GO:0019864,GO:0030881,GO:0042605" IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor|protein binding|extracellular space|immune response|external side of plasma membrane|endosome membrane|integral component of membrane|IgG binding|beta-2-microglobulin binding|peptide antigen binding FCHO1 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.068374487 0.013846678 23149 FCH and mu domain containing endocytic adaptor 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005905,GO:0030136,GO:0035612,GO:0048268,GO:0061024,GO:0072583" protein binding|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|clathrin-coated pit|clathrin-coated vesicle|AP-2 adaptor complex binding|clathrin coat assembly|membrane organization|clathrin-dependent endocytosis FCHO2 561.829839 487.1788648 636.4808131 1.306462285 0.385665478 0.331818434 1 4.284405424 5.838528 115548 FCH and mu domain containing endocytic adaptor 2 "GO:0001786,GO:0005515,GO:0005546,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005905,GO:0010324,GO:0030136,GO:0035091,GO:0042802,GO:0048268,GO:0048488,GO:0061024,GO:0072583,GO:0072659,GO:0098835" "phosphatidylserine binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|clathrin-coated pit|membrane invagination|clathrin-coated vesicle|phosphatidylinositol binding|identical protein binding|clathrin coat assembly|synaptic vesicle endocytosis|membrane organization|clathrin-dependent endocytosis|protein localization to plasma membrane|presynaptic endocytic zone membrane" FCHSD1 723.8882681 519.6574558 928.1190804 1.786020907 0.836748968 0.026248882 0.720197064 5.710309589 10.63805234 89848 FCH and double SH3 domains 1 "GO:0007274,GO:0008289,GO:0030833,GO:0030838,GO:0031594,GO:0032437,GO:0042995,GO:0043204,GO:0044803,GO:0055037" neuromuscular synaptic transmission|lipid binding|regulation of actin filament polymerization|positive regulation of actin filament polymerization|neuromuscular junction|cuticular plate|cell projection|perikaryon|multi-organism membrane organization|recycling endosome FCHSD2 1086.392336 1053.524295 1119.260377 1.062396361 0.08732211 0.803644473 1 10.24328834 11.3512033 9873 FCH and double SH3 domains 2 "GO:0005515,GO:0005547,GO:0005886,GO:0005905,GO:0007274,GO:0015031,GO:0030833,GO:0030838,GO:0031594,GO:0043325,GO:0055037,GO:0072583,GO:0120043,GO:2000601" "protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|plasma membrane|clathrin-coated pit|neuromuscular synaptic transmission|protein transport|regulation of actin filament polymerization|positive regulation of actin filament polymerization|neuromuscular junction|phosphatidylinositol-3,4-bisphosphate binding|recycling endosome|clathrin-dependent endocytosis|stereocilium shaft|positive regulation of Arp2/3 complex-mediated actin nucleation" FCMR 53.36486043 44.65806261 62.07165824 1.389931731 0.475014024 0.576849365 1 0.754679121 1.094137075 9214 Fc fragment of IgM receptor "GO:0002376,GO:0004888,GO:0005576,GO:0005886,GO:0006968,GO:0016021,GO:0043066" immune system process|transmembrane signaling receptor activity|extracellular region|plasma membrane|cellular defense response|integral component of membrane|negative regulation of apoptotic process FCRLB 22.65835998 33.49354696 11.823173 0.352998535 -1.5022659 0.166371257 1 0.838107705 0.308594844 127943 Fc receptor like B "GO:0004888,GO:0005737,GO:0005783,GO:0005887,GO:0007166,GO:0050777" transmembrane signaling receptor activity|cytoplasm|endoplasmic reticulum|integral component of plasma membrane|cell surface receptor signaling pathway|negative regulation of immune response FCSK 184.1835789 197.9164138 170.4507441 0.861225912 -0.215536367 0.70311431 1 1.960831016 1.761461624 197258 fucose kinase "GO:0005515,GO:0005524,GO:0005829,GO:0042352,GO:0046835,GO:0050201,GO:1903350" protein binding|ATP binding|cytosol|GDP-L-fucose salvage|carbohydrate phosphorylation|fucokinase activity|response to dopamine "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism FDFT1 1404.034706 1248.395841 1559.673571 1.249342172 0.321168659 0.336970359 1 15.09354148 19.66928089 2222 farnesyl-diphosphate farnesyltransferase 1 "GO:0004310,GO:0005515,GO:0005783,GO:0005789,GO:0006694,GO:0006695,GO:0016021,GO:0019216,GO:0045338,GO:0045540,GO:0046872,GO:0051996" farnesyl-diphosphate farnesyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|steroid biosynthetic process|cholesterol biosynthetic process|integral component of membrane|regulation of lipid metabolic process|farnesyl diphosphate metabolic process|regulation of cholesterol biosynthetic process|metal ion binding|squalene synthase activity hsa00100 Steroid biosynthesis FDPS 2265.232265 1960.894931 2569.569598 1.310406569 0.390014494 0.223144158 1 58.48787434 79.9443598 2224 farnesyl diphosphate synthase "GO:0003723,GO:0004161,GO:0004337,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006695,GO:0016032,GO:0033384,GO:0045337,GO:0045540,GO:0046872" RNA binding|dimethylallyltranstransferase activity|geranyltranstransferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|cholesterol biosynthetic process|viral process|geranyl diphosphate biosynthetic process|farnesyl diphosphate biosynthetic process|regulation of cholesterol biosynthetic process|metal ion binding "hsa00900,hsa05164,hsa05166" Terpenoid backbone biosynthesis|Influenza A|Human T-cell leukemia virus 1 infection FDX1 303.342428 362.3392807 244.3455753 0.674355744 -0.568418235 0.228015959 1 5.836897682 4.105698664 2230 ferredoxin 1 "GO:0005506,GO:0005739,GO:0005759,GO:0006700,GO:0008203,GO:0009055,GO:0016125,GO:0022900,GO:0042446,GO:0044281,GO:0051537,GO:0071320,GO:1904322" "iron ion binding|mitochondrion|mitochondrial matrix|C21-steroid hormone biosynthetic process|cholesterol metabolic process|electron transfer activity|sterol metabolic process|electron transport chain|hormone biosynthetic process|small molecule metabolic process|2 iron, 2 sulfur cluster binding|cellular response to cAMP|cellular response to forskolin" FDX2 320.9017598 316.6662621 325.1372575 1.026750546 0.038085714 0.941523661 1 15.84785479 16.97271643 112812 ferredoxin 2 "GO:0005515,GO:0005759,GO:0006700,GO:0009055,GO:0016125,GO:0022900,GO:0044281,GO:0046872,GO:0051537" "protein binding|mitochondrial matrix|C21-steroid hormone biosynthetic process|electron transfer activity|sterol metabolic process|electron transport chain|small molecule metabolic process|metal ion binding|2 iron, 2 sulfur cluster binding" FDXACB1 105.3233315 127.884452 82.76221099 0.64716398 -0.627796782 0.347700415 1 2.334858091 1.576125361 91893 ferredoxin-fold anticodon binding domain containing 1 "GO:0005515,GO:0005737,GO:0070042,GO:0070475" protein binding|cytoplasm|rRNA (uridine-N3-)-methyltransferase activity|rRNA base methylation FDXR 415.5707752 389.7430919 441.3984586 1.132536966 0.17955814 0.678780856 1 9.189531039 10.85579578 2232 ferredoxin reductase "GO:0004324,GO:0005739,GO:0005743,GO:0005759,GO:0006091,GO:0006694,GO:0006700,GO:0006744,GO:0008203,GO:0015039,GO:0016125,GO:0016491,GO:0055114" ferredoxin-NADP+ reductase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|generation of precursor metabolites and energy|steroid biosynthetic process|C21-steroid hormone biosynthetic process|ubiquinone biosynthetic process|cholesterol metabolic process|NADPH-adrenodoxin reductase activity|sterol metabolic process|oxidoreductase activity|oxidation-reduction process FECH 1375.671117 1431.087915 1320.254318 0.922552908 -0.116296443 0.73004106 1 9.197912987 8.851084945 2235 ferrochelatase "GO:0004325,GO:0005515,GO:0005739,GO:0005743,GO:0005759,GO:0006091,GO:0006783,GO:0008198,GO:0009416,GO:0010288,GO:0017085,GO:0042493,GO:0045471,GO:0046501,GO:0046685,GO:0051537,GO:0051597,GO:0070541,GO:0071549" "ferrochelatase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|generation of precursor metabolites and energy|heme biosynthetic process|ferrous iron binding|response to light stimulus|response to lead ion|response to insecticide|response to drug|response to ethanol|protoporphyrinogen IX metabolic process|response to arsenic-containing substance|2 iron, 2 sulfur cluster binding|response to methylmercury|response to platinum ion|cellular response to dexamethasone stimulus" hsa00860 Porphyrin and chlorophyll metabolism FEM1A 535.7891176 559.2407386 512.3374966 0.916130498 -0.126374977 0.756312233 1 2.968927728 2.837088588 55527 fem-1 homolog A "GO:0000151,GO:0005515,GO:0005829,GO:0006511,GO:0016567,GO:0031867,GO:0043687,GO:0050728,GO:0051438" ubiquitin ligase complex|protein binding|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|EP4 subtype prostaglandin E2 receptor binding|post-translational protein modification|negative regulation of inflammatory response|regulation of ubiquitin-protein transferase activity FEM1B 1025.907938 993.641893 1058.173983 1.064945018 0.090778947 0.797954542 1 7.011906998 7.788956224 10116 fem-1 homolog B "GO:0005123,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0016567,GO:0043687,GO:0051438,GO:0060442,GO:0060743,GO:1902041,GO:2000001" death receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|protein ubiquitination|post-translational protein modification|regulation of ubiquitin-protein transferase activity|branching involved in prostate gland morphogenesis|epithelial cell maturation involved in prostate gland development|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of DNA damage checkpoint FEM1C 609.7527345 631.3026123 588.2028567 0.93172885 -0.10201793 0.796655587 1 5.215013899 5.068284005 56929 fem-1 homolog C "GO:0000151,GO:0005515,GO:0005654,GO:0005829,GO:0006511,GO:0016567,GO:0043687" ubiquitin ligase complex|protein binding|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|post-translational protein modification FEN1 2367.565906 2322.219256 2412.912556 1.039054581 0.055271441 0.863794862 1 58.33939137 63.22898136 2237 flap structure-specific endonuclease 1 "GO:0000287,GO:0000724,GO:0000781,GO:0003677,GO:0003684,GO:0003690,GO:0004519,GO:0004523,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0006260,GO:0006281,GO:0006284,GO:0006302,GO:0007613,GO:0008309,GO:0008409,GO:0009650,GO:0016020,GO:0017108,GO:0030145,GO:0032201,GO:0032991,GO:0043137,GO:0045876,GO:0048256,GO:0090305,GO:0090502" "magnesium ion binding|double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|damaged DNA binding|double-stranded DNA binding|endonuclease activity|RNA-DNA hybrid ribonuclease activity|exonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|mitochondrion|DNA replication|DNA repair|base-excision repair|double-strand break repair|memory|double-stranded DNA exodeoxyribonuclease activity|5'-3' exonuclease activity|UV protection|membrane|5'-flap endonuclease activity|manganese ion binding|telomere maintenance via semi-conservative replication|protein-containing complex|DNA replication, removal of RNA primer|positive regulation of sister chromatid cohesion|flap endonuclease activity|nucleic acid phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03030,hsa03410,hsa03450" DNA replication|Base excision repair|Non-homologous end-joining FER 1241.509377 1082.958018 1400.060736 1.292811644 0.370512097 0.276374108 1 3.356465527 4.526196201 2241 FER tyrosine kinase "GO:0000226,GO:0000785,GO:0001932,GO:0004713,GO:0004715,GO:0005102,GO:0005154,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005938,GO:0006468,GO:0006935,GO:0007155,GO:0007169,GO:0007260,GO:0008157,GO:0008283,GO:0008284,GO:0008289,GO:0010591,GO:0010762,GO:0015629,GO:0015630,GO:0018108,GO:0019221,GO:0030027,GO:0030054,GO:0030154,GO:0030335,GO:0030838,GO:0031234,GO:0031532,GO:0032496,GO:0032869,GO:0033007,GO:0034446,GO:0034614,GO:0035426,GO:0035556,GO:0036006,GO:0036119,GO:0038028,GO:0038083,GO:0038095,GO:0038109,GO:0042058,GO:0042127,GO:0043304,GO:0044331,GO:0045087,GO:0046777,GO:0048008,GO:0050904,GO:0051092,GO:0070102" microtubule cytoskeleton organization|chromatin|regulation of protein phosphorylation|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|epidermal growth factor receptor binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cell cortex|protein phosphorylation|chemotaxis|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|tyrosine phosphorylation of STAT protein|protein phosphatase 1 binding|cell population proliferation|positive regulation of cell population proliferation|lipid binding|regulation of lamellipodium assembly|regulation of fibroblast migration|actin cytoskeleton|microtubule cytoskeleton|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|lamellipodium|cell junction|cell differentiation|positive regulation of cell migration|positive regulation of actin filament polymerization|extrinsic component of cytoplasmic side of plasma membrane|actin cytoskeleton reorganization|response to lipopolysaccharide|cellular response to insulin stimulus|negative regulation of mast cell activation involved in immune response|substrate adhesion-dependent cell spreading|cellular response to reactive oxygen species|extracellular matrix-cell signaling|intracellular signal transduction|cellular response to macrophage colony-stimulating factor stimulus|response to platelet-derived growth factor|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|Kit signaling pathway|regulation of epidermal growth factor receptor signaling pathway|regulation of cell population proliferation|regulation of mast cell degranulation|cell-cell adhesion mediated by cadherin|innate immune response|protein autophosphorylation|platelet-derived growth factor receptor signaling pathway|diapedesis|positive regulation of NF-kappaB transcription factor activity|interleukin-6-mediated signaling pathway hsa04520 Adherens junction FER1L6 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.025718043 0.026041108 654463 fer-1 like family member 6 "GO:0007009,GO:0009617,GO:0016021,GO:0046872" plasma membrane organization|response to bacterium|integral component of membrane|metal ion binding FERMT1 444.7493985 464.8498335 424.6489635 0.913518588 -0.13049401 0.760505941 1 5.07720599 4.837913534 55612 FERM domain containing kindlin 1 "GO:0001954,GO:0005178,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0007155,GO:0007160,GO:0007229,GO:0010629,GO:0030054,GO:0030055,GO:0030511,GO:0032587,GO:0033625,GO:0033630,GO:0042308,GO:0043616,GO:0051015,GO:0051546,GO:0051886,GO:0071636,GO:0071711,GO:0071944,GO:0090090,GO:0090162,GO:1903691,GO:2000647" "positive regulation of cell-matrix adhesion|integrin binding|cytoplasm|cytosol|cytoskeleton|focal adhesion|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|negative regulation of gene expression|cell junction|cell-substrate junction|positive regulation of transforming growth factor beta receptor signaling pathway|ruffle membrane|positive regulation of integrin activation|positive regulation of cell adhesion mediated by integrin|negative regulation of protein import into nucleus|keratinocyte proliferation|actin filament binding|keratinocyte migration|negative regulation of timing of anagen|positive regulation of transforming growth factor beta production|basement membrane organization|cell periphery|negative regulation of canonical Wnt signaling pathway|establishment of epithelial cell polarity|positive regulation of wound healing, spreading of epidermal cells|negative regulation of stem cell proliferation" FERMT2 1465.863143 1669.602568 1262.123718 0.755942607 -0.40365139 0.224878587 1 23.27538675 18.3527716 10979 FERM domain containing kindlin 2 "GO:0001725,GO:0003779,GO:0005178,GO:0005515,GO:0005547,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005925,GO:0005938,GO:0007155,GO:0007160,GO:0007179,GO:0007229,GO:0008360,GO:0009986,GO:0010718,GO:0016055,GO:0019901,GO:0022604,GO:0030054,GO:0030055,GO:0030335,GO:0031234,GO:0031258,GO:0031674,GO:0033622,GO:0033625,GO:0034329,GO:0034334,GO:0034446,GO:0034713,GO:0035505,GO:0043116,GO:0043547,GO:0045599,GO:0045669,GO:0046332,GO:0048041,GO:0051015,GO:0051496,GO:0051894,GO:0051897,GO:0060173,GO:0060548,GO:0070374,GO:0072657,GO:1900026,GO:1900182,GO:1902414,GO:1902462,GO:1903691" "stress fiber|actin binding|integrin binding|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|adherens junction|focal adhesion|cell cortex|cell adhesion|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|regulation of cell shape|cell surface|positive regulation of epithelial to mesenchymal transition|Wnt signaling pathway|protein kinase binding|regulation of cell morphogenesis|cell junction|cell-substrate junction|positive regulation of cell migration|extrinsic component of cytoplasmic side of plasma membrane|lamellipodium membrane|I band|integrin activation|positive regulation of integrin activation|cell junction assembly|adherens junction maintenance|substrate adhesion-dependent cell spreading|type I transforming growth factor beta receptor binding|positive regulation of myosin light chain kinase activity|negative regulation of vascular permeability|positive regulation of GTPase activity|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|SMAD binding|focal adhesion assembly|actin filament binding|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|limb development|negative regulation of cell death|positive regulation of ERK1 and ERK2 cascade|protein localization to membrane|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of protein localization to nucleus|protein localization to cell junction|positive regulation of mesenchymal stem cell proliferation|positive regulation of wound healing, spreading of epidermal cells" FERMT3 16.55377839 20.29911937 12.80843742 0.630984881 -0.664322658 0.596432277 1 0.353777971 0.232844332 83706 FERM domain containing kindlin 3 "GO:0002102,GO:0002576,GO:0005178,GO:0005576,GO:0007159,GO:0007160,GO:0007229,GO:0016020,GO:0030055,GO:0030335,GO:0031093,GO:0033622,GO:0033632,GO:0034446,GO:0042995,GO:0070062,GO:0070527" podosome|platelet degranulation|integrin binding|extracellular region|leukocyte cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|membrane|cell-substrate junction|positive regulation of cell migration|platelet alpha granule lumen|integrin activation|regulation of cell-cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading|cell projection|extracellular exosome|platelet aggregation hsa04611 Platelet activation FES 14.67232421 26.38885518 2.95579325 0.11200915 -3.158311499 0.021168788 0.629214381 0.473937029 0.055371983 2242 "FES proto-oncogene, tyrosine kinase" "GO:0001578,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0005925,GO:0006935,GO:0007098,GO:0007155,GO:0007169,GO:0008017,GO:0008360,GO:0010976,GO:0015630,GO:0018108,GO:0030154,GO:0030155,GO:0031116,GO:0031234,GO:0031410,GO:0034987,GO:0035091,GO:0038083,GO:0042127,GO:0043304,GO:0045087,GO:0045595,GO:0045639,GO:0045657,GO:0046777,GO:0060627,GO:0071305,GO:2000145,GO:2000251" microtubule bundle formation|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|cytoplasm|Golgi apparatus|cytosol|focal adhesion|chemotaxis|centrosome cycle|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|microtubule binding|regulation of cell shape|positive regulation of neuron projection development|microtubule cytoskeleton|peptidyl-tyrosine phosphorylation|cell differentiation|regulation of cell adhesion|positive regulation of microtubule polymerization|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|immunoglobulin receptor binding|phosphatidylinositol binding|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|regulation of mast cell degranulation|innate immune response|regulation of cell differentiation|positive regulation of myeloid cell differentiation|positive regulation of monocyte differentiation|protein autophosphorylation|regulation of vesicle-mediated transport|cellular response to vitamin D|regulation of cell motility|positive regulation of actin cytoskeleton reorganization hsa04360 Axon guidance FEZ1 3054.066336 3485.358795 2622.773877 0.752511873 -0.410213749 0.197499225 1 27.70697338 21.74795241 9638 fasciculation and elongation protein zeta 1 "GO:0005080,GO:0005515,GO:0005737,GO:0005739,GO:0005794,GO:0005813,GO:0005874,GO:0005886,GO:0007155,GO:0007399,GO:0007411,GO:0010976,GO:0021766,GO:0030010,GO:0030424,GO:0030425,GO:0030426,GO:0043015,GO:0043025,GO:0045666,GO:0047485,GO:0051654,GO:0061881,GO:0070584,GO:0071363,GO:1902902" protein kinase C binding|protein binding|cytoplasm|mitochondrion|Golgi apparatus|centrosome|microtubule|plasma membrane|cell adhesion|nervous system development|axon guidance|positive regulation of neuron projection development|hippocampus development|establishment of cell polarity|axon|dendrite|growth cone|gamma-tubulin binding|neuronal cell body|positive regulation of neuron differentiation|protein N-terminus binding|establishment of mitochondrion localization|positive regulation of anterograde axonal transport of mitochondrion|mitochondrion morphogenesis|cellular response to growth factor stimulus|negative regulation of autophagosome assembly FEZ2 586.3966231 550.1061349 622.6871113 1.131939951 0.178797426 0.651424725 1 12.50490802 14.76453656 9637 fasciculation and elongation protein zeta 2 "GO:0005515,GO:0005737,GO:0007165,GO:0007399,GO:0007411,GO:0030424,GO:1902902" protein binding|cytoplasm|signal transduction|nervous system development|axon guidance|axon|negative regulation of autophagosome assembly FEZF1 21.88365803 14.20938356 29.5579325 2.080169937 1.056701392 0.336231713 1 0.176342845 0.382624335 389549 FEZ family zinc finger 1 "GO:0000122,GO:0000978,GO:0001227,GO:0001764,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0007411,GO:0008285,GO:0021772,GO:0021797,GO:0043697,GO:0045666,GO:0045893,GO:0046872,GO:0050767" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|neuron migration|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|axon guidance|negative regulation of cell population proliferation|olfactory bulb development|forebrain anterior/posterior pattern specification|cell dedifferentiation|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|metal ion binding|regulation of neurogenesis" zf-C2H2 FFAR4 8.463822196 6.08973581 10.83790858 1.779700946 0.831634837 0.617753532 1 0.070739366 0.131317959 338557 free fatty acid receptor 4 "GO:0001818,GO:0004930,GO:0005504,GO:0005765,GO:0005886,GO:0005887,GO:0005929,GO:0006954,GO:0007186,GO:0007200,GO:0007204,GO:0008527,GO:0010008,GO:0010827,GO:0030139,GO:0032691,GO:0036321,GO:0043066,GO:0043950,GO:0045669,GO:0046879,GO:0050728,GO:0050872,GO:0050873,GO:0050912,GO:0060170,GO:0070094,GO:0070374,GO:0090275,GO:0090336,GO:0120162" negative regulation of cytokine production|G protein-coupled receptor activity|fatty acid binding|lysosomal membrane|plasma membrane|integral component of plasma membrane|cilium|inflammatory response|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|taste receptor activity|endosome membrane|regulation of glucose transmembrane transport|endocytic vesicle|negative regulation of interleukin-1 beta production|ghrelin secretion|negative regulation of apoptotic process|positive regulation of cAMP-mediated signaling|positive regulation of osteoblast differentiation|hormone secretion|negative regulation of inflammatory response|white fat cell differentiation|brown fat cell differentiation|detection of chemical stimulus involved in sensory perception of taste|ciliary membrane|positive regulation of glucagon secretion|positive regulation of ERK1 and ERK2 cascade|negative regulation of somatostatin secretion|positive regulation of brown fat cell differentiation|positive regulation of cold-induced thermogenesis FGD1 795.8731914 692.1999704 899.5464123 1.299547025 0.37800884 0.304230086 1 8.072182033 10.94205456 2245 "FYVE, RhoGEF and PH domain containing 1" "GO:0001726,GO:0005085,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0007010,GO:0007165,GO:0007186,GO:0007275,GO:0008360,GO:0009887,GO:0030027,GO:0030036,GO:0031267,GO:0043065,GO:0043087,GO:0046847,GO:0046872,GO:0051056" ruffle|guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|cytoskeleton organization|signal transduction|G protein-coupled receptor signaling pathway|multicellular organism development|regulation of cell shape|animal organ morphogenesis|lamellipodium|actin cytoskeleton organization|small GTPase binding|positive regulation of apoptotic process|regulation of GTPase activity|filopodium assembly|metal ion binding|regulation of small GTPase mediated signal transduction hsa04810 Regulation of actin cytoskeleton FGD3 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.051097355 0.012934807 89846 "FYVE, RhoGEF and PH domain containing 3" "GO:0001726,GO:0005085,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0007010,GO:0007186,GO:0008360,GO:0030027,GO:0030036,GO:0031267,GO:0043065,GO:0043087,GO:0046847,GO:0046872,GO:0051056" ruffle|guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|cytoskeleton organization|G protein-coupled receptor signaling pathway|regulation of cell shape|lamellipodium|actin cytoskeleton organization|small GTPase binding|positive regulation of apoptotic process|regulation of GTPase activity|filopodium assembly|metal ion binding|regulation of small GTPase mediated signal transduction hsa04810 Regulation of actin cytoskeleton FGD4 313.550133 218.2155332 408.8847329 1.873765478 0.905940395 0.05296742 1 1.11152036 2.172443975 121512 "FYVE, RhoGEF and PH domain containing 4" "GO:0001726,GO:0003779,GO:0005085,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0007010,GO:0007186,GO:0008360,GO:0030027,GO:0030036,GO:0030175,GO:0031267,GO:0043065,GO:0043087,GO:0046847,GO:0046872,GO:0051056" ruffle|actin binding|guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|cytoskeleton organization|G protein-coupled receptor signaling pathway|regulation of cell shape|lamellipodium|actin cytoskeleton organization|filopodium|small GTPase binding|positive regulation of apoptotic process|regulation of GTPase activity|filopodium assembly|metal ion binding|regulation of small GTPase mediated signal transduction FGD6 187.4538551 185.7369422 189.170768 1.018487576 0.026428381 0.972420444 1 1.012476685 1.07561462 55785 "FYVE, RhoGEF and PH domain containing 6" "GO:0001726,GO:0005085,GO:0005737,GO:0005794,GO:0005856,GO:0007010,GO:0008360,GO:0030027,GO:0030036,GO:0031267,GO:0043087,GO:0046847,GO:0046872" ruffle|guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytoskeleton|cytoskeleton organization|regulation of cell shape|lamellipodium|actin cytoskeleton organization|small GTPase binding|regulation of GTPase activity|filopodium assembly|metal ion binding FGF1 3.970749218 2.029911937 5.911586499 2.912237912 1.542128219 0.515744462 1 0.021298504 0.064698153 2246 fibroblast growth factor 1 "GO:0000165,GO:0000187,GO:0001525,GO:0001759,GO:0001934,GO:0005104,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005938,GO:0007165,GO:0007275,GO:0008083,GO:0008201,GO:0008284,GO:0008543,GO:0009653,GO:0009887,GO:0010595,GO:0010628,GO:0030154,GO:0030324,GO:0030334,GO:0030335,GO:0030544,GO:0031012,GO:0032148,GO:0034605,GO:0042060,GO:0043406,GO:0044548,GO:0045542,GO:0045766,GO:0045944,GO:0050679,GO:0051781,GO:0051897,GO:0060681,GO:0072163,GO:1901509,GO:1902533,GO:1903672,GO:2000347,GO:2000544" MAPK cascade|activation of MAPK activity|angiogenesis|organ induction|positive regulation of protein phosphorylation|fibroblast growth factor receptor binding|integrin binding|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|cell cortex|signal transduction|multicellular organism development|growth factor activity|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|anatomical structure morphogenesis|animal organ morphogenesis|positive regulation of endothelial cell migration|positive regulation of gene expression|cell differentiation|lung development|regulation of cell migration|positive regulation of cell migration|Hsp70 protein binding|extracellular matrix|activation of protein kinase B activity|cellular response to heat|wound healing|positive regulation of MAP kinase activity|S100 protein binding|positive regulation of cholesterol biosynthetic process|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of epithelial cell proliferation|positive regulation of cell division|positive regulation of protein kinase B signaling|branch elongation involved in ureteric bud branching|mesonephric epithelium development|regulation of endothelial tube morphogenesis|positive regulation of intracellular signal transduction|positive regulation of sprouting angiogenesis|positive regulation of hepatocyte proliferation|regulation of endothelial cell chemotaxis to fibroblast growth factor "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04390,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Hippo signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF11 106.7715366 125.8545401 87.68853307 0.696745092 -0.521297161 0.434719905 1 2.408042488 1.75006425 2256 fibroblast growth factor 11 "GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0007165,GO:0007267,GO:0007399,GO:0008083,GO:0017080,GO:1905150" protein binding|extracellular region|nucleus|cytoplasm|signal transduction|cell-cell signaling|nervous system development|growth factor activity|sodium channel regulator activity|regulation of voltage-gated sodium channel activity FGF12 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.02102984 0.042588024 2257 fibroblast growth factor 12 "GO:0003254,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0007165,GO:0007267,GO:0007268,GO:0007399,GO:0007507,GO:0008083,GO:0008344,GO:0008543,GO:0010765,GO:0017080,GO:0044325,GO:0045202,GO:0050905,GO:0086002,GO:0098908,GO:1902305,GO:1905150,GO:2000649,GO:2001258" regulation of membrane depolarization|protein binding|extracellular space|nucleus|cytoplasm|signal transduction|cell-cell signaling|chemical synaptic transmission|nervous system development|heart development|growth factor activity|adult locomotory behavior|fibroblast growth factor receptor signaling pathway|positive regulation of sodium ion transport|sodium channel regulator activity|ion channel binding|synapse|neuromuscular process|cardiac muscle cell action potential involved in contraction|regulation of neuronal action potential|regulation of sodium ion transmembrane transport|regulation of voltage-gated sodium channel activity|regulation of sodium ion transmembrane transporter activity|negative regulation of cation channel activity FGF13 32.58523302 38.5683268 26.60213925 0.689740558 -0.535874293 0.591775103 1 0.094501678 0.067989401 2258 fibroblast growth factor 13 "GO:0000165,GO:0001764,GO:0005515,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005874,GO:0005886,GO:0006814,GO:0007026,GO:0007165,GO:0007267,GO:0007399,GO:0007612,GO:0007613,GO:0008017,GO:0008083,GO:0014704,GO:0016328,GO:0017080,GO:0021766,GO:0021795,GO:0030175,GO:0030295,GO:0030424,GO:0030425,GO:0030426,GO:0032147,GO:0043005,GO:0044325,GO:0045200,GO:0046785,GO:0048487,GO:0048671,GO:0072659,GO:0098909,GO:1904862,GO:1905150" MAPK cascade|neuron migration|protein binding|extracellular region|nucleus|nucleolus|cytoplasm|cytosol|microtubule|plasma membrane|sodium ion transport|negative regulation of microtubule depolymerization|signal transduction|cell-cell signaling|nervous system development|learning|memory|microtubule binding|growth factor activity|intercalated disc|lateral plasma membrane|sodium channel regulator activity|hippocampus development|cerebral cortex cell migration|filopodium|protein kinase activator activity|axon|dendrite|growth cone|activation of protein kinase activity|neuron projection|ion channel binding|establishment of neuroblast polarity|microtubule polymerization|beta-tubulin binding|negative regulation of collateral sprouting|protein localization to plasma membrane|regulation of cardiac muscle cell action potential involved in regulation of contraction|inhibitory synapse assembly|regulation of voltage-gated sodium channel activity FGF18 4.552456082 8.119647747 0.985264417 0.121343246 -3.042834281 0.175274214 1 0.205821579 0.026050883 8817 fibroblast growth factor 18 "GO:0000165,GO:0001525,GO:0001934,GO:0001936,GO:0001957,GO:0001958,GO:0002063,GO:0005104,GO:0005105,GO:0005111,GO:0005576,GO:0005615,GO:0005730,GO:0005737,GO:0007165,GO:0007267,GO:0008083,GO:0008284,GO:0008543,GO:0009653,GO:0009887,GO:0010628,GO:0030154,GO:0030324,GO:0030334,GO:0030949,GO:0032332,GO:0043406,GO:0043536,GO:0045766,GO:0051897,GO:0070374,GO:1903670,GO:2000546" MAPK cascade|angiogenesis|positive regulation of protein phosphorylation|regulation of endothelial cell proliferation|intramembranous ossification|endochondral ossification|chondrocyte development|fibroblast growth factor receptor binding|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding|extracellular region|extracellular space|nucleolus|cytoplasm|signal transduction|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|anatomical structure morphogenesis|animal organ morphogenesis|positive regulation of gene expression|cell differentiation|lung development|regulation of cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of chondrocyte differentiation|positive regulation of MAP kinase activity|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|regulation of sprouting angiogenesis|positive regulation of endothelial cell chemotaxis to fibroblast growth factor "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF2 914.8726963 980.4474654 849.2979271 0.866235017 -0.207169601 0.563864049 1 7.329329198 6.622407397 2247 fibroblast growth factor 2 "GO:0000165,GO:0000187,GO:0001658,GO:0001934,GO:0001938,GO:0002042,GO:0005104,GO:0005125,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0006661,GO:0006935,GO:0007165,GO:0007265,GO:0007399,GO:0008083,GO:0008201,GO:0008284,GO:0008543,GO:0009887,GO:0010595,GO:0010628,GO:0010629,GO:0010764,GO:0010863,GO:0014068,GO:0014843,GO:0019221,GO:0019956,GO:0030154,GO:0030198,GO:0030214,GO:0030324,GO:0030334,GO:0030374,GO:0032958,GO:0035019,GO:0038001,GO:0040037,GO:0042056,GO:0042060,GO:0042660,GO:0042802,GO:0043406,GO:0043410,GO:0043536,GO:0043537,GO:0043552,GO:0045765,GO:0045766,GO:0045893,GO:0045944,GO:0048598,GO:0050679,GO:0050918,GO:0051209,GO:0051781,GO:0051897,GO:0060045,GO:0060548,GO:0060591,GO:0061045,GO:0070374,GO:0072089,GO:0090049,GO:0090050,GO:0090722,GO:1902748,GO:1902895,GO:1903587,GO:1903672,GO:1904707,GO:1905278,GO:1905564,GO:2000544,GO:2000546,GO:2000573,GO:2001028" "MAPK cascade|activation of MAPK activity|branching involved in ureteric bud morphogenesis|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|fibroblast growth factor receptor binding|cytokine activity|integrin binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|phosphatidylinositol biosynthetic process|chemotaxis|signal transduction|Ras protein signal transduction|nervous system development|growth factor activity|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|animal organ morphogenesis|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|negative regulation of fibroblast migration|positive regulation of phospholipase C activity|positive regulation of phosphatidylinositol 3-kinase signaling|growth factor dependent regulation of skeletal muscle satellite cell proliferation|cytokine-mediated signaling pathway|chemokine binding|cell differentiation|extracellular matrix organization|hyaluronan catabolic process|lung development|regulation of cell migration|nuclear receptor coactivator activity|inositol phosphate biosynthetic process|somatic stem cell population maintenance|paracrine signaling|negative regulation of fibroblast growth factor receptor signaling pathway|chemoattractant activity|wound healing|positive regulation of cell fate specification|identical protein binding|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|regulation of angiogenesis|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic morphogenesis|positive regulation of epithelial cell proliferation|positive chemotaxis|release of sequestered calcium ion into cytosol|positive regulation of cell division|positive regulation of protein kinase B signaling|positive regulation of cardiac muscle cell proliferation|negative regulation of cell death|chondroblast differentiation|negative regulation of wound healing|positive regulation of ERK1 and ERK2 cascade|stem cell proliferation|regulation of cell migration involved in sprouting angiogenesis|positive regulation of cell migration involved in sprouting angiogenesis|receptor-receptor interaction|positive regulation of lens fiber cell differentiation|positive regulation of pri-miRNA transcription by RNA polymerase II|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of sprouting angiogenesis|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of epithelial tube formation|positive regulation of vascular endothelial cell proliferation|regulation of endothelial cell chemotaxis to fibroblast growth factor|positive regulation of endothelial cell chemotaxis to fibroblast growth factor|positive regulation of DNA biosynthetic process|positive regulation of endothelial cell chemotaxis" "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04550,hsa04810,hsa05167,hsa05200,hsa05205,hsa05218,hsa05224,hsa05226" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|Melanoma|Breast cancer|Gastric cancer FGF5 300.4690284 266.9334197 334.0046372 1.251265719 0.323388193 0.495837161 1 2.375964152 3.101025658 2250 fibroblast growth factor 5 "GO:0000165,GO:0001934,GO:0005104,GO:0005576,GO:0005615,GO:0005737,GO:0007267,GO:0007399,GO:0008083,GO:0008284,GO:0008543,GO:0009887,GO:0010001,GO:0010628,GO:0023019,GO:0030154,GO:0030334,GO:0051781,GO:0051897" MAPK cascade|positive regulation of protein phosphorylation|fibroblast growth factor receptor binding|extracellular region|extracellular space|cytoplasm|cell-cell signaling|nervous system development|growth factor activity|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|animal organ morphogenesis|glial cell differentiation|positive regulation of gene expression|signal transduction involved in regulation of gene expression|cell differentiation|regulation of cell migration|positive regulation of cell division|positive regulation of protein kinase B signaling "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGFBP1 62.2740559 81.19647747 43.35163433 0.533910284 -0.905330758 0.254193483 1 3.043904619 1.695177797 9982 fibroblast growth factor binding protein 1 "GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007165,GO:0007267,GO:0008201,GO:0008285,GO:0008543,GO:0009986,GO:0017134,GO:0019838,GO:0045743,GO:0090050,GO:1903589" protein binding|extracellular region|extracellular space|plasma membrane|signal transduction|cell-cell signaling|heparin binding|negative regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|cell surface|fibroblast growth factor binding|growth factor binding|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis FGFBP3 55.21390145 70.03196182 40.39584108 0.576820069 -0.793806733 0.33688184 1 1.389295655 0.835893542 143282 fibroblast growth factor binding protein 3 "GO:0005576,GO:0007267,GO:0008201,GO:0017134,GO:0019838,GO:0043117,GO:0045743,GO:0062023" extracellular region|cell-cell signaling|heparin binding|fibroblast growth factor binding|growth factor binding|positive regulation of vascular permeability|positive regulation of fibroblast growth factor receptor signaling pathway|collagen-containing extracellular matrix FGFR1 1460.528066 1372.220469 1548.835663 1.128707593 0.174671785 0.6002925 1 9.41453886 11.08399774 2260 fibroblast growth factor receptor 1 "GO:0000165,GO:0001501,GO:0001764,GO:0001837,GO:0004713,GO:0004714,GO:0005007,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005829,GO:0005886,GO:0005887,GO:0006468,GO:0007169,GO:0007275,GO:0008201,GO:0008284,GO:0008543,GO:0010518,GO:0010863,GO:0014068,GO:0016021,GO:0016477,GO:0017134,GO:0018108,GO:0031410,GO:0033674,GO:0042802,GO:0042803,GO:0043009,GO:0043235,GO:0043406,GO:0043410,GO:0043536,GO:0045595,GO:0045597,GO:0045666,GO:0046777,GO:0048015,GO:0048705,GO:0051897,GO:0090722,GO:1905564,GO:2000546,GO:2001239" MAPK cascade|skeletal system development|neuron migration|epithelial to mesenchymal transition|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|fibroblast growth factor-activated receptor activity|protein binding|ATP binding|extracellular region|nucleus|cytosol|plasma membrane|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|positive regulation of phospholipase activity|positive regulation of phospholipase C activity|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|cell migration|fibroblast growth factor binding|peptidyl-tyrosine phosphorylation|cytoplasmic vesicle|positive regulation of kinase activity|identical protein binding|protein homodimerization activity|chordate embryonic development|receptor complex|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of blood vessel endothelial cell migration|regulation of cell differentiation|positive regulation of cell differentiation|positive regulation of neuron differentiation|protein autophosphorylation|phosphatidylinositol-mediated signaling|skeletal system morphogenesis|positive regulation of protein kinase B signaling|receptor-receptor interaction|positive regulation of vascular endothelial cell proliferation|positive regulation of endothelial cell chemotaxis to fibroblast growth factor|regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04520,hsa04550,hsa04714,hsa04810,hsa04928,hsa05200,hsa05205,hsa05215,hsa05218,hsa05224,hsa05230" "MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Thermogenesis|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Proteoglycans in cancer|Prostate cancer|Melanoma|Breast cancer|Central carbon metabolism in cancer" FGFR1OP2 595.1249476 607.9586251 582.2912702 0.957781083 -0.062232154 0.877757467 1 10.07887385 10.06918208 26127 FGFR1 oncogene partner 2 "GO:0005515,GO:0005829,GO:0009611,GO:0042060,GO:0042802" protein binding|cytosol|response to wounding|wound healing|identical protein binding FGFR3 51.81273492 39.58328277 64.04218708 1.617909951 0.694131313 0.412445724 1 0.449194181 0.758061425 2261 fibroblast growth factor receptor 3 "GO:0000165,GO:0001501,GO:0001958,GO:0002062,GO:0003416,GO:0004713,GO:0004714,GO:0005007,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005925,GO:0007169,GO:0007267,GO:0007275,GO:0008284,GO:0008543,GO:0009986,GO:0010518,GO:0017134,GO:0018108,GO:0030133,GO:0030282,GO:0033674,GO:0035988,GO:0042531,GO:0042802,GO:0043235,GO:0043410,GO:0043552,GO:0046777,GO:0048640,GO:0051897,GO:0060349,GO:0070374,GO:0070977,GO:1902178" MAPK cascade|skeletal system development|endochondral ossification|chondrocyte differentiation|endochondral bone growth|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|fibroblast growth factor-activated receptor activity|protein binding|ATP binding|extracellular region|nucleus|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|focal adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|cell-cell signaling|multicellular organism development|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|cell surface|positive regulation of phospholipase activity|fibroblast growth factor binding|peptidyl-tyrosine phosphorylation|transport vesicle|bone mineralization|positive regulation of kinase activity|chondrocyte proliferation|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|receptor complex|positive regulation of MAPK cascade|positive regulation of phosphatidylinositol 3-kinase activity|protein autophosphorylation|negative regulation of developmental growth|positive regulation of protein kinase B signaling|bone morphogenesis|positive regulation of ERK1 and ERK2 cascade|bone maturation|fibroblast growth factor receptor apoptotic signaling pathway "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04144,hsa04151,hsa04550,hsa04810,hsa05200,hsa05206,hsa05219,hsa05230" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer|MicroRNAs in cancer|Bladder cancer|Central carbon metabolism in cancer FGFR4 87.42526847 116.7199364 58.13060058 0.498034889 -1.005681283 0.157127053 1 1.903236643 0.988709002 2264 fibroblast growth factor receptor 4 "GO:0000165,GO:0004714,GO:0005007,GO:0005515,GO:0005524,GO:0005576,GO:0005768,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005911,GO:0007169,GO:0007275,GO:0008201,GO:0008284,GO:0008543,GO:0010628,GO:0010715,GO:0016477,GO:0017134,GO:0018108,GO:0019216,GO:0030133,GO:0033674,GO:0042593,GO:0042632,GO:0043085,GO:0043235,GO:0045862,GO:0046777,GO:0051897,GO:0055062,GO:0070374,GO:0070857,GO:1903412,GO:2000573" MAPK cascade|transmembrane receptor protein tyrosine kinase activity|fibroblast growth factor-activated receptor activity|protein binding|ATP binding|extracellular region|endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell-cell junction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|positive regulation of gene expression|regulation of extracellular matrix disassembly|cell migration|fibroblast growth factor binding|peptidyl-tyrosine phosphorylation|regulation of lipid metabolic process|transport vesicle|positive regulation of kinase activity|glucose homeostasis|cholesterol homeostasis|positive regulation of catalytic activity|receptor complex|positive regulation of proteolysis|protein autophosphorylation|positive regulation of protein kinase B signaling|phosphate ion homeostasis|positive regulation of ERK1 and ERK2 cascade|regulation of bile acid biosynthetic process|response to bile acid|positive regulation of DNA biosynthetic process "hsa04010,hsa04014,hsa04015,hsa04020,hsa04144,hsa04151,hsa04550,hsa04810,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer FGFRL1 956.8624786 1022.06066 891.664297 0.872418176 -0.196908267 0.580322219 1 11.3343041 10.31419874 53834 fibroblast growth factor receptor like 1 "GO:0005007,GO:0005794,GO:0005886,GO:0008201,GO:0008543,GO:0016021,GO:0017134,GO:0030133,GO:0042802,GO:0044291,GO:0098742" fibroblast growth factor-activated receptor activity|Golgi apparatus|plasma membrane|heparin binding|fibroblast growth factor receptor signaling pathway|integral component of membrane|fibroblast growth factor binding|transport vesicle|identical protein binding|cell-cell contact zone|cell-cell adhesion via plasma-membrane adhesion molecules FGGY 58.67717268 71.04691779 46.30742758 0.65178658 -0.617528447 0.448561387 1 0.320673358 0.21801392 55277 FGGY carbohydrate kinase domain containing "GO:0005575,GO:0019150,GO:0019321,GO:0046835,GO:0070050" cellular_component|D-ribulokinase activity|pentose metabolic process|carbohydrate phosphorylation|neuron cellular homeostasis FH 1701.994552 1714.260631 1689.728474 0.985689366 -0.020795033 0.951158774 1 37.39072067 38.44322707 2271 fumarate hydratase "GO:0004333,GO:0005515,GO:0005634,GO:0005694,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006099,GO:0006106,GO:0006108,GO:0006281,GO:0045239,GO:0048873,GO:0070062,GO:0120162" fumarate hydratase activity|protein binding|nucleus|chromosome|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|tricarboxylic acid cycle|fumarate metabolic process|malate metabolic process|DNA repair|tricarboxylic acid cycle enzyme complex|homeostasis of number of cells within a tissue|extracellular exosome|positive regulation of cold-induced thermogenesis "hsa00020,hsa00620,hsa04934,hsa05200,hsa05211" Citrate cycle (TCA cycle)|Pyruvate metabolism|Cushing syndrome|Pathways in cancer|Renal cell carcinoma FHAD1 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.036333008 0.014715766 114827 forkhead associated phosphopeptide binding domain 1 FHDC1 93.96854237 58.86744617 129.0696386 2.192546933 1.132607725 0.103592978 1 0.404480868 0.925044898 85462 FH2 domain containing 1 "GO:0003779,GO:0005794,GO:0005874,GO:0005881,GO:0005929,GO:0008017,GO:0043149,GO:0060271,GO:0090161" actin binding|Golgi apparatus|microtubule|cytoplasmic microtubule|cilium|microtubule binding|stress fiber assembly|cilium assembly|Golgi ribbon formation FHIP1A 407.5995852 383.653356 431.5458144 1.124832632 0.169710354 0.697451649 1 1.463595137 1.717215479 729830 FHF complex subunit HOOK interacting protein 1A FHIP1B 522.4786454 491.2386887 553.7186021 1.127188503 0.172728802 0.671722865 1 6.810705337 8.00764057 84067 FHF complex subunit HOOK interacting protein 1B FHIP2A 335.0990192 310.5765263 359.621512 1.157915945 0.21153053 0.646797602 1 2.571457481 3.105791606 57700 FHF complex subunit HOOK interacting protein 2A FHIP2B 741.5945738 686.1102346 797.078913 1.161735932 0.216282175 0.563416715 1 8.531564678 10.33836925 64760 FHF complex subunit HOOK interacting protein 2B FHIT 32.34770061 22.3290313 42.36636991 1.897367124 0.923998855 0.343491938 1 0.187450135 0.370982188 2272 fragile histidine triad diadenosine triphosphatase "GO:0000166,GO:0001650,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006163,GO:0015964,GO:0031625,GO:0032435,GO:0042802,GO:0047710,GO:0072332" nucleotide binding|fibrillar center|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|plasma membrane|purine nucleotide metabolic process|diadenosine triphosphate catabolic process|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|bis(5'-adenosyl)-triphosphatase activity|intrinsic apoptotic signaling pathway by p53 class mediator "hsa00230,hsa05222,hsa05223" Purine metabolism|Small cell lung cancer|Non-small cell lung cancer FHL1 5206.901753 5104.213565 5309.589941 1.040236635 0.056911752 0.860065269 1 66.31873024 71.95886037 2273 four and a half LIM domains 1 "GO:0003254,GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0007517,GO:0009887,GO:0010972,GO:0030154,GO:0030308,GO:0043268,GO:0044325,GO:0046872,GO:1901016,GO:2000134" regulation of membrane depolarization|molecular_function|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|muscle organ development|animal organ morphogenesis|negative regulation of G2/M transition of mitotic cell cycle|cell differentiation|negative regulation of cell growth|positive regulation of potassium ion transport|ion channel binding|metal ion binding|regulation of potassium ion transmembrane transporter activity|negative regulation of G1/S transition of mitotic cell cycle hsa04630 JAK-STAT signaling pathway FHL2 1262.556228 1107.316961 1417.795495 1.280388132 0.356581209 0.293627778 1 10.19667231 13.61808474 2274 four and a half LIM domains 2 "GO:0000122,GO:0001649,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005925,GO:0008134,GO:0009725,GO:0019216,GO:0030018,GO:0031430,GO:0042802,GO:0043066,GO:0043425,GO:0046872,GO:0055014,GO:0055015,GO:0060347,GO:0070885" negative regulation of transcription by RNA polymerase II|osteoblast differentiation|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|focal adhesion|transcription factor binding|response to hormone|regulation of lipid metabolic process|Z disc|M band|identical protein binding|negative regulation of apoptotic process|bHLH transcription factor binding|metal ion binding|atrial cardiac muscle cell development|ventricular cardiac muscle cell development|heart trabecula formation|negative regulation of calcineurin-NFAT signaling cascade hsa04380 Osteoclast differentiation FHL3 231.5653456 204.0061496 259.1245416 1.270180051 0.345033017 0.504489676 1 6.063492834 8.033486828 2275 four and a half LIM domains 3 "GO:0001725,GO:0003712,GO:0003779,GO:0005515,GO:0005634,GO:0005925,GO:0006355,GO:0007517,GO:0030018,GO:0030036,GO:0046872" "stress fiber|transcription coregulator activity|actin binding|protein binding|nucleus|focal adhesion|regulation of transcription, DNA-templated|muscle organ development|Z disc|actin cytoskeleton organization|metal ion binding" FHOD1 353.1967583 436.4310664 269.9624501 0.618568363 -0.692995048 0.12372029 1 5.126088561 3.307422972 29109 formin homology 2 domain containing 1 "GO:0001725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0007097,GO:0014704,GO:0016020,GO:0019904,GO:0030866,GO:0032059,GO:0042802,GO:0043621,GO:0045944,GO:0051015,GO:0051492,GO:0051496,GO:0051639,GO:0051660" stress fiber|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|nuclear migration|intercalated disc|membrane|protein domain specific binding|cortical actin cytoskeleton organization|bleb|identical protein binding|protein self-association|positive regulation of transcription by RNA polymerase II|actin filament binding|regulation of stress fiber assembly|positive regulation of stress fiber assembly|actin filament network formation|establishment of centrosome localization hsa05132 Salmonella infection FHOD3 1174.130604 1360.040998 988.2202098 0.726610603 -0.460745676 0.179619951 1 8.868453533 6.721489983 80206 formin homology 2 domain containing 3 "GO:0005515,GO:0005737,GO:0005856,GO:0005865,GO:0030018,GO:0030837,GO:0030866,GO:0045214,GO:0051015,GO:0051639,GO:0055003" protein binding|cytoplasm|cytoskeleton|striated muscle thin filament|Z disc|negative regulation of actin filament polymerization|cortical actin cytoskeleton organization|sarcomere organization|actin filament binding|actin filament network formation|cardiac myofibril assembly FIBCD1 47.5247812 83.22638941 11.823173 0.142060386 -2.815423785 0.002458153 0.160955592 1.154828224 0.171122182 84929 fibrinogen C domain containing 1 "GO:0005102,GO:0005515,GO:0005615,GO:0007155,GO:0008061,GO:0016020,GO:0016021,GO:0046872,GO:0062023" signaling receptor binding|protein binding|extracellular space|cell adhesion|chitin binding|membrane|integral component of membrane|metal ion binding|collagen-containing extracellular matrix FIBP 1468.098174 1721.365322 1214.831026 0.7057369 -0.502797651 0.130705055 1 55.21284418 40.64422758 9158 FGF1 intracellular binding protein "GO:0005634,GO:0005739,GO:0008543,GO:0012505,GO:0016020,GO:0016607,GO:0017134,GO:0070527" nucleus|mitochondrion|fibroblast growth factor receptor signaling pathway|endomembrane system|membrane|nuclear speck|fibroblast growth factor binding|platelet aggregation FICD 263.8266932 186.7518982 340.9014881 1.825424488 0.86823199 0.078888537 1 2.905783355 5.532775313 11153 FIC domain protein adenylyltransferase "GO:0005515,GO:0005524,GO:0006986,GO:0018117,GO:0030176,GO:0030544,GO:0034260,GO:0034976,GO:0042802,GO:0042803,GO:0044602,GO:0044603,GO:0051087,GO:0070733,GO:1903894" protein binding|ATP binding|response to unfolded protein|protein adenylylation|integral component of endoplasmic reticulum membrane|Hsp70 protein binding|negative regulation of GTPase activity|response to endoplasmic reticulum stress|identical protein binding|protein homodimerization activity|protein deadenylylation|protein adenylylhydrolase activity|chaperone binding|protein adenylyltransferase activity|regulation of IRE1-mediated unfolded protein response FIG4 165.9440631 163.4079109 168.4802152 1.031040751 0.044101356 0.949861185 1 1.790961744 1.926096623 9896 FIG4 phosphoinositide 5-phosphatase "GO:0000139,GO:0005515,GO:0005811,GO:0006661,GO:0010008,GO:0031901,GO:0031902,GO:0036092,GO:0043231,GO:0043813,GO:0046856" "Golgi membrane|protein binding|lipid droplet|phosphatidylinositol biosynthetic process|endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol-3-phosphate biosynthetic process|intracellular membrane-bounded organelle|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol dephosphorylation" "hsa00562,hsa05014,hsa05022" Inositol phosphate metabolism|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases FIGN 373.7415749 392.7879598 354.69519 0.903019507 -0.147170941 0.743449596 1 1.004003457 0.945688853 55137 "fidgetin, microtubule severing factor" "GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005874,GO:0007049,GO:0008022,GO:0008568,GO:0016363,GO:0016887,GO:0031122,GO:0051013,GO:0051301" protein binding|ATP binding|nucleus|cytoplasm|microtubule organizing center|microtubule|cell cycle|protein C-terminus binding|microtubule-severing ATPase activity|nuclear matrix|ATPase activity|cytoplasmic microtubule organization|microtubule severing|cell division FIGNL1 1470.440093 1376.280293 1564.599893 1.136832302 0.185019453 0.578440557 1 6.435577659 7.631323605 63979 fidgetin like 1 "GO:0000228,GO:0000287,GO:0001649,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0007140,GO:0008568,GO:0010569,GO:0016787,GO:0016887,GO:0031122,GO:0033687,GO:0043066,GO:0046034,GO:0048471,GO:0051013,GO:0051726,GO:0070062,GO:0071479,GO:2001243" nuclear chromosome|magnesium ion binding|osteoblast differentiation|protein binding|ATP binding|nucleus|cytoplasm|male meiotic nuclear division|microtubule-severing ATPase activity|regulation of double-strand break repair via homologous recombination|hydrolase activity|ATPase activity|cytoplasmic microtubule organization|osteoblast proliferation|negative regulation of apoptotic process|ATP metabolic process|perinuclear region of cytoplasm|microtubule severing|regulation of cell cycle|extracellular exosome|cellular response to ionizing radiation|negative regulation of intrinsic apoptotic signaling pathway FIGNL2 5.956123827 3.044867905 8.867379749 2.912237912 1.542128219 0.403727794 1 0.026442356 0.080323555 401720 fidgetin like 2 "GO:0005524,GO:0005634,GO:0008568,GO:0016887,GO:0031122,GO:0051013" ATP binding|nucleus|microtubule-severing ATPase activity|ATPase activity|cytoplasmic microtubule organization|microtubule severing FILIP1L 545.7011449 563.3005624 528.1017273 0.937513226 -0.093089052 0.819688176 1 4.246678518 4.152816277 11259 filamin A interacting protein 1 like "GO:0003674,GO:0005634,GO:0005737,GO:0008150,GO:0016020" molecular_function|nucleus|cytoplasm|biological_process|membrane FIP1L1 730.4246149 730.7682972 730.0809327 0.999059395 -0.001357645 1 1 7.194952616 7.497822863 81608 factor interacting with PAPOLA and CPSF1 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006406,GO:0031124,GO:0098789" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA export from nucleus|mRNA 3'-end processing|pre-mRNA cleavage required for polyadenylation" hsa03015 mRNA surveillance pathway FIS1 1335.556108 1281.889388 1389.222827 1.083730656 0.116006242 0.731813419 1 74.62433939 84.35635153 51024 "fission, mitochondrial 1" "GO:0000266,GO:0000422,GO:0001836,GO:0005515,GO:0005739,GO:0005777,GO:0005779,GO:0005783,GO:0006626,GO:0007204,GO:0008053,GO:0010821,GO:0016020,GO:0016559,GO:0031307,GO:0032471,GO:0032991,GO:0035584,GO:0042802,GO:0043280,GO:0043653,GO:0051561,GO:0070584,GO:0090141,GO:0090314,GO:1903579,GO:2000192,GO:2001244" mitochondrial fission|autophagy of mitochondrion|release of cytochrome c from mitochondria|protein binding|mitochondrion|peroxisome|integral component of peroxisomal membrane|endoplasmic reticulum|protein targeting to mitochondrion|positive regulation of cytosolic calcium ion concentration|mitochondrial fusion|regulation of mitochondrion organization|membrane|peroxisome fission|integral component of mitochondrial outer membrane|negative regulation of endoplasmic reticulum calcium ion concentration|protein-containing complex|calcium-mediated signaling using intracellular calcium source|identical protein binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|mitochondrial fragmentation involved in apoptotic process|positive regulation of mitochondrial calcium ion concentration|mitochondrion morphogenesis|positive regulation of mitochondrial fission|positive regulation of protein targeting to membrane|negative regulation of ATP metabolic process|negative regulation of fatty acid transport|positive regulation of intrinsic apoptotic signaling pathway hsa04137 Mitophagy - animal FITM1 6.015506931 7.104691779 4.926322083 0.693389979 -0.528261108 0.84291128 1 0.199019676 0.143942654 161247 fat storage inducing transmembrane protein 1 "GO:0003674,GO:0005789,GO:0008654,GO:0010890,GO:0017129,GO:0019915,GO:0019992,GO:0030176,GO:0034389,GO:0140042" molecular_function|endoplasmic reticulum membrane|phospholipid biosynthetic process|positive regulation of sequestering of triglyceride|triglyceride binding|lipid storage|diacylglycerol binding|integral component of endoplasmic reticulum membrane|lipid droplet organization|lipid droplet formation FITM2 719.3882681 784.5609636 654.2155726 0.833861998 -0.262119454 0.486009757 1 8.585835142 7.467799633 128486 fat storage inducing transmembrane protein 2 "GO:0005515,GO:0005789,GO:0007010,GO:0008654,GO:0010866,GO:0010890,GO:0017129,GO:0019915,GO:0019992,GO:0022604,GO:0030176,GO:0030730,GO:0034389,GO:0035356,GO:0036115,GO:0055088,GO:0140042" protein binding|endoplasmic reticulum membrane|cytoskeleton organization|phospholipid biosynthetic process|regulation of triglyceride biosynthetic process|positive regulation of sequestering of triglyceride|triglyceride binding|lipid storage|diacylglycerol binding|regulation of cell morphogenesis|integral component of endoplasmic reticulum membrane|sequestering of triglyceride|lipid droplet organization|cellular triglyceride homeostasis|fatty-acyl-CoA catabolic process|lipid homeostasis|lipid droplet formation FIZ1 220.7098696 236.4847406 204.9349986 0.866588678 -0.206580708 0.697562912 1 3.156025783 2.852787892 84922 FLT3 interacting zinc finger 1 "GO:0000785,GO:0001102,GO:0001934,GO:0003713,GO:0005634,GO:0005737,GO:0030971,GO:0045944,GO:0046872" chromatin|RNA polymerase II activating transcription factor binding|positive regulation of protein phosphorylation|transcription coactivator activity|nucleus|cytoplasm|receptor tyrosine kinase binding|positive regulation of transcription by RNA polymerase II|metal ion binding FJX1 596.3719928 693.2149264 499.5290592 0.720597668 -0.472734113 0.227407479 1 14.59222382 10.96807128 24147 four-jointed box kinase 1 "GO:0005615,GO:0007267,GO:0010842" extracellular space|cell-cell signaling|retina layer formation FKBP10 8185.434041 9656.291083 6714.576999 0.695357766 -0.52417265 0.114151491 1 180.5971485 130.9890909 60681 FKBP prolyl isomerase 10 "GO:0000413,GO:0001701,GO:0003755,GO:0005509,GO:0005515,GO:0005528,GO:0005758,GO:0005783,GO:0005788,GO:0016020,GO:0017185,GO:0018208,GO:0030199,GO:0035909,GO:0042060,GO:0085029" protein peptidyl-prolyl isomerization|in utero embryonic development|peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|protein binding|FK506 binding|mitochondrial intermembrane space|endoplasmic reticulum|endoplasmic reticulum lumen|membrane|peptidyl-lysine hydroxylation|peptidyl-proline modification|collagen fibril organization|aorta morphogenesis|wound healing|extracellular matrix assembly FKBP11 386.9535698 386.698224 387.2089157 1.001320647 0.001904034 1 1 14.14072264 14.76932696 51303 FKBP prolyl isomerase 11 "GO:0000413,GO:0003755,GO:0016020,GO:0016021" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|membrane|integral component of membrane FKBP14 916.4072544 1018.000836 814.8136725 0.800405701 -0.321196653 0.369788624 1 10.3572019 8.647061448 55033 FKBP prolyl isomerase 14 "GO:0000413,GO:0003755,GO:0005509,GO:0005515,GO:0005788,GO:0036498" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|protein binding|endoplasmic reticulum lumen|IRE1-mediated unfolded protein response FKBP15 1353.042448 1399.62428 1306.460616 0.933436662 -0.099375963 0.768980882 1 8.04243615 7.830480381 23307 FKBP prolyl isomerase family member 15 "GO:0000413,GO:0003755,GO:0003779,GO:0005515,GO:0005769,GO:0006897,GO:0010923,GO:0016020,GO:0030426" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|actin binding|protein binding|early endosome|endocytosis|negative regulation of phosphatase activity|membrane|growth cone FKBP1A 31833.26593 30134.0427 33532.48915 1.112777648 0.154165346 0.695110314 1 813.9642434 944.7777358 2280 FKBP prolyl isomerase 1A "GO:0000413,GO:0003007,GO:0003755,GO:0005160,GO:0005515,GO:0005527,GO:0005528,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0007183,GO:0014802,GO:0016020,GO:0016529,GO:0019855,GO:0022417,GO:0030018,GO:0031312,GO:0031398,GO:0032092,GO:0032515,GO:0032880,GO:0032925,GO:0034713,GO:0042026,GO:0042110,GO:0043123,GO:0044325,GO:0046332,GO:0048185,GO:0050776,GO:0051280,GO:0055010,GO:0060314,GO:0060315,GO:0060347,GO:0061077,GO:0070588,GO:0097435,GO:0098562,GO:1901393,GO:1902991,GO:1990000,GO:1990425" protein peptidyl-prolyl isomerization|heart morphogenesis|peptidyl-prolyl cis-trans isomerase activity|transforming growth factor beta receptor binding|protein binding|macrolide binding|FK506 binding|cytoplasm|cytosol|protein folding|'de novo' protein folding|SMAD protein complex assembly|terminal cisterna|membrane|sarcoplasmic reticulum|calcium channel inhibitor activity|protein maturation by protein folding|Z disc|extrinsic component of organelle membrane|positive regulation of protein ubiquitination|positive regulation of protein binding|negative regulation of phosphoprotein phosphatase activity|regulation of protein localization|regulation of activin receptor signaling pathway|type I transforming growth factor beta receptor binding|protein refolding|T cell activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|ion channel binding|SMAD binding|activin binding|regulation of immune response|negative regulation of release of sequestered calcium ion into cytosol|ventricular cardiac muscle tissue morphogenesis|regulation of ryanodine-sensitive calcium-release channel activity|negative regulation of ryanodine-sensitive calcium-release channel activity|heart trabecula formation|chaperone-mediated protein folding|calcium ion transmembrane transport|supramolecular fiber organization|cytoplasmic side of membrane|negative regulation of transforming growth factor beta1 activation|regulation of amyloid precursor protein catabolic process|amyloid fibril formation|ryanodine receptor complex FKBP1B 422.6457755 401.9225635 443.3689874 1.103120421 0.14159029 0.74404059 1 5.554150052 6.390818191 2281 FKBP prolyl isomerase 1B "GO:0000413,GO:0003755,GO:0005102,GO:0005219,GO:0005515,GO:0005528,GO:0005737,GO:0005829,GO:0006458,GO:0006939,GO:0009749,GO:0010459,GO:0010880,GO:0010881,GO:0016020,GO:0019227,GO:0019855,GO:0022417,GO:0030018,GO:0030073,GO:0030551,GO:0032515,GO:0033017,GO:0033197,GO:0034220,GO:0034704,GO:0035584,GO:0042026,GO:0042098,GO:0042542,GO:0044325,GO:0048680,GO:0051209,GO:0051280,GO:0051284,GO:0051480,GO:0051775,GO:0060314,GO:0060315,GO:0061077,GO:0061179,GO:0086064,GO:1903779" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|signaling receptor binding|ryanodine-sensitive calcium-release channel activity|protein binding|FK506 binding|cytoplasm|cytosol|'de novo' protein folding|smooth muscle contraction|response to glucose|negative regulation of heart rate|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|membrane|neuronal action potential propagation|calcium channel inhibitor activity|protein maturation by protein folding|Z disc|insulin secretion|cyclic nucleotide binding|negative regulation of phosphoprotein phosphatase activity|sarcoplasmic reticulum membrane|response to vitamin E|ion transmembrane transport|calcium channel complex|calcium-mediated signaling using intracellular calcium source|protein refolding|T cell proliferation|response to hydrogen peroxide|ion channel binding|positive regulation of axon regeneration|release of sequestered calcium ion into cytosol|negative regulation of release of sequestered calcium ion into cytosol|positive regulation of sequestering of calcium ion|regulation of cytosolic calcium ion concentration|response to redox state|regulation of ryanodine-sensitive calcium-release channel activity|negative regulation of ryanodine-sensitive calcium-release channel activity|chaperone-mediated protein folding|negative regulation of insulin secretion involved in cellular response to glucose stimulus|cell communication by electrical coupling involved in cardiac conduction|regulation of cardiac conduction FKBP3 1722.30728 1587.391135 1857.223425 1.169984753 0.22648973 0.488114015 1 20.59845272 25.13800053 2287 FKBP prolyl isomerase 3 "GO:0000413,GO:0003723,GO:0003755,GO:0005515,GO:0005528,GO:0005634,GO:0038023" protein peptidyl-prolyl isomerization|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|FK506 binding|nucleus|signaling receptor activity FKBP4 2630.950939 2983.970547 2277.931331 0.763389348 -0.389509038 0.221867642 1 42.65525865 33.96523356 2288 FKBP prolyl isomerase 4 "GO:0000413,GO:0003723,GO:0003755,GO:0005515,GO:0005528,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0006457,GO:0006825,GO:0010977,GO:0030674,GO:0031072,GO:0031111,GO:0031115,GO:0032767,GO:0032991,GO:0043025,GO:0044295,GO:0048156,GO:0048471,GO:0061077,GO:0070062,GO:1900034" protein peptidyl-prolyl isomerization|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|FK506 binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|microtubule|protein folding|copper ion transport|negative regulation of neuron projection development|protein-macromolecule adaptor activity|heat shock protein binding|negative regulation of microtubule polymerization or depolymerization|negative regulation of microtubule polymerization|copper-dependent protein binding|protein-containing complex|neuronal cell body|axonal growth cone|tau protein binding|perinuclear region of cytoplasm|chaperone-mediated protein folding|extracellular exosome|regulation of cellular response to heat hsa04915 Estrogen signaling pathway FKBP5 327.2911327 315.6513062 338.9309593 1.07375117 0.102659703 0.829124702 1 1.508741516 1.689796557 2289 FKBP prolyl isomerase 5 "GO:0000413,GO:0003755,GO:0005515,GO:0005528,GO:0005654,GO:0005737,GO:0005829,GO:0006457,GO:0009617,GO:0016020,GO:0031072,GO:0061077,GO:0070062" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|FK506 binding|nucleoplasm|cytoplasm|cytosol|protein folding|response to bacterium|membrane|heat shock protein binding|chaperone-mediated protein folding|extracellular exosome hsa04915 Estrogen signaling pathway FKBP7 99.60474009 141.0788796 58.13060058 0.412043254 -1.279132305 0.061546951 1 2.532842097 1.088596299 51661 FKBP prolyl isomerase 7 "GO:0000413,GO:0003755,GO:0005509,GO:0005515,GO:0005528,GO:0005783,GO:0005788,GO:0018208" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|protein binding|FK506 binding|endoplasmic reticulum|endoplasmic reticulum lumen|peptidyl-proline modification FKBP8 4633.152739 4879.908296 4386.397182 0.898868773 -0.153817585 0.631038326 1 140.3464735 131.5872248 23770 FKBP prolyl isomerase 8 "GO:0000413,GO:0001708,GO:0001933,GO:0003755,GO:0005515,GO:0005739,GO:0005783,GO:0005829,GO:0006457,GO:0006915,GO:0007224,GO:0010468,GO:0016020,GO:0016032,GO:0021904,GO:0030176,GO:0030513,GO:0031966,GO:0032991,GO:0035264,GO:0035556,GO:0042802,GO:0043010,GO:0043066,GO:0044183,GO:0046872,GO:0097718" protein peptidyl-prolyl isomerization|cell fate specification|negative regulation of protein phosphorylation|peptidyl-prolyl cis-trans isomerase activity|protein binding|mitochondrion|endoplasmic reticulum|cytosol|protein folding|apoptotic process|smoothened signaling pathway|regulation of gene expression|membrane|viral process|dorsal/ventral neural tube patterning|integral component of endoplasmic reticulum membrane|positive regulation of BMP signaling pathway|mitochondrial membrane|protein-containing complex|multicellular organism growth|intracellular signal transduction|identical protein binding|camera-type eye development|negative regulation of apoptotic process|protein folding chaperone|metal ion binding|disordered domain specific binding FKBP9 3730.802451 3745.187523 3716.417379 0.992318103 -0.011125422 0.97303722 1 32.7543664 33.90283742 11328 FKBP prolyl isomerase 9 "GO:0000413,GO:0003755,GO:0005509,GO:0005783,GO:0006457" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|endoplasmic reticulum|protein folding FKBPL 120.9094129 115.7049804 126.1138453 1.089960388 0.124275705 0.856859042 1 4.366653558 4.964498476 63943 FKBP prolyl isomerase like "GO:0005515,GO:0005576,GO:0005829,GO:0009314,GO:0050821,GO:1905553" protein binding|extracellular region|cytosol|response to radiation|protein stabilization|regulation of blood vessel branching FKRP 433.2285842 418.161859 448.2953095 1.072061691 0.100387927 0.817396848 1 6.183481159 6.914626857 79147 fukutin related protein "GO:0000139,GO:0002162,GO:0005615,GO:0005654,GO:0005791,GO:0005794,GO:0005829,GO:0016021,GO:0016485,GO:0016740,GO:0035269,GO:0042383" Golgi membrane|dystroglycan binding|extracellular space|nucleoplasm|rough endoplasmic reticulum|Golgi apparatus|cytosol|integral component of membrane|protein processing|transferase activity|protein O-linked mannosylation|sarcolemma hsa00515 Mannose type O-glycan biosynthesis FKTN 722.5870369 733.8131651 711.3609087 0.969403307 -0.044831091 0.908509913 1 2.671822292 2.70164322 2218 fukutin "GO:0005515,GO:0005615,GO:0005634,GO:0005783,GO:0005794,GO:0005801,GO:0006493,GO:0007399,GO:0007517,GO:0008285,GO:0016740,GO:0030173,GO:0035269,GO:0046329,GO:0060049" protein binding|extracellular space|nucleus|endoplasmic reticulum|Golgi apparatus|cis-Golgi network|protein O-linked glycosylation|nervous system development|muscle organ development|negative regulation of cell population proliferation|transferase activity|integral component of Golgi membrane|protein O-linked mannosylation|negative regulation of JNK cascade|regulation of protein glycosylation hsa00515 Mannose type O-glycan biosynthesis FLACC1 10.56796301 15.22433953 5.911586499 0.388298388 -1.364762376 0.333261624 1 0.246896922 0.099999354 130540 flagellum associated containing coiled-coil domains 1 "GO:0001520,GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0035686,GO:0036126" outer dense fiber|molecular_function|protein binding|cellular_component|cytoplasm|sperm fibrous sheath|sperm flagellum FLAD1 604.5861584 648.5568638 560.615453 0.864404471 -0.21022156 0.591839999 1 12.89639465 11.62789896 80308 flavin adenine dinucleotide synthetase 1 "GO:0003919,GO:0005515,GO:0005524,GO:0005759,GO:0005829,GO:0005886,GO:0006747,GO:0006771,GO:0042802" FMN adenylyltransferase activity|protein binding|ATP binding|mitochondrial matrix|cytosol|plasma membrane|FAD biosynthetic process|riboflavin metabolic process|identical protein binding hsa00740 Riboflavin metabolism FLCN 1036.398951 1037.285 1035.512902 0.9982916 -0.002466808 0.997539313 1 8.577114435 8.931297397 201163 folliculin "GO:0000122,GO:0001701,GO:0001932,GO:0001934,GO:0005085,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005813,GO:0005829,GO:0005886,GO:0005929,GO:0007043,GO:0009267,GO:0010508,GO:0010629,GO:0010823,GO:0030097,GO:0030308,GO:0030336,GO:0030496,GO:0030511,GO:0031929,GO:0032006,GO:0032007,GO:0032008,GO:0032418,GO:0032465,GO:0034198,GO:0035024,GO:0035065,GO:0043065,GO:0043547,GO:0044291,GO:0044877,GO:0045785,GO:0045944,GO:0046578,GO:0051898,GO:0070373,GO:0072686,GO:0097009,GO:0120163,GO:1900181,GO:1901723,GO:1903444,GO:1904263,GO:2000973,GO:2001170" negative regulation of transcription by RNA polymerase II|in utero embryonic development|regulation of protein phosphorylation|positive regulation of protein phosphorylation|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleus|cytoplasm|lysosome|lysosomal membrane|centrosome|cytosol|plasma membrane|cilium|cell-cell junction assembly|cellular response to starvation|positive regulation of autophagy|negative regulation of gene expression|negative regulation of mitochondrion organization|hemopoiesis|negative regulation of cell growth|negative regulation of cell migration|midbody|positive regulation of transforming growth factor beta receptor signaling pathway|TOR signaling|regulation of TOR signaling|negative regulation of TOR signaling|positive regulation of TOR signaling|lysosome localization|regulation of cytokinesis|cellular response to amino acid starvation|negative regulation of Rho protein signal transduction|regulation of histone acetylation|positive regulation of apoptotic process|positive regulation of GTPase activity|cell-cell contact zone|protein-containing complex binding|positive regulation of cell adhesion|positive regulation of transcription by RNA polymerase II|regulation of Ras protein signal transduction|negative regulation of protein kinase B signaling|negative regulation of ERK1 and ERK2 cascade|mitotic spindle|energy homeostasis|negative regulation of cold-induced thermogenesis|negative regulation of protein localization to nucleus|negative regulation of cell proliferation involved in kidney development|negative regulation of brown fat cell differentiation|positive regulation of TORC1 signaling|regulation of pro-B cell differentiation|negative regulation of ATP biosynthetic process "hsa04150,hsa05211" mTOR signaling pathway|Renal cell carcinoma FLI1 782.7690762 840.3835418 725.1546106 0.862885307 -0.212759283 0.565412667 1 8.339040301 7.50559414 2313 "Fli-1 proto-oncogene, ETS transcription factor" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007599,GO:0008015,GO:0009887,GO:0016604,GO:0030154,GO:0035855,GO:0045893,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|hemostasis|blood circulation|animal organ morphogenesis|nuclear body|cell differentiation|megakaryocyte development|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer ETS FLII 7087.835366 6523.122009 7652.548723 1.17314205 0.230377712 0.482270019 1 69.89065317 85.52353248 2314 FLII actin remodeling protein "GO:0003779,GO:0005515,GO:0005546,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005903,GO:0005925,GO:0007275,GO:0008154,GO:0015629,GO:0030239,GO:0034451,GO:0051014,GO:0051015,GO:0051016" "actin binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|nucleoplasm|cytoplasm|cytosol|brush border|focal adhesion|multicellular organism development|actin polymerization or depolymerization|actin cytoskeleton|myofibril assembly|centriolar satellite|actin filament severing|actin filament binding|barbed-end actin filament capping" FLNA 55965.85834 63343.40199 48588.3147 0.76706197 -0.382584959 0.380885275 1 377.115299 301.7314172 2316 filamin A "GO:0001525,GO:0001664,GO:0001837,GO:0001974,GO:0002576,GO:0003007,GO:0003723,GO:0005080,GO:0005515,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0005802,GO:0005829,GO:0005884,GO:0005886,GO:0005903,GO:0005911,GO:0005925,GO:0007195,GO:0008134,GO:0010977,GO:0015459,GO:0015629,GO:0016020,GO:0016479,GO:0019900,GO:0021943,GO:0021987,GO:0030018,GO:0030168,GO:0030334,GO:0030863,GO:0031267,GO:0031523,GO:0031532,GO:0031852,GO:0032233,GO:0032432,GO:0034329,GO:0034394,GO:0034988,GO:0042177,GO:0042307,GO:0042789,GO:0042803,GO:0043066,GO:0043113,GO:0043123,GO:0043198,GO:0043204,GO:0043433,GO:0044295,GO:0044319,GO:0044325,GO:0045022,GO:0045184,GO:0045216,GO:0045296,GO:0046332,GO:0048471,GO:0048680,GO:0050808,GO:0050821,GO:0051015,GO:0051020,GO:0051220,GO:0051607,GO:0051764,GO:0060271,GO:0070062,GO:0070527,GO:0071526,GO:0072659,GO:0090042,GO:0090307,GO:0097368,GO:0097440,GO:0098794,GO:0098978,GO:1900026,GO:1901381,GO:1902396,GO:1905000,GO:1905031,GO:2000179,GO:2001046,GO:2001224" "angiogenesis|G protein-coupled receptor binding|epithelial to mesenchymal transition|blood vessel remodeling|platelet degranulation|heart morphogenesis|RNA binding|protein kinase C binding|protein binding|extracellular region|nucleus|nucleolus|cytoplasm|trans-Golgi network|cytosol|actin filament|plasma membrane|brush border|cell-cell junction|focal adhesion|adenylate cyclase-inhibiting dopamine receptor signaling pathway|transcription factor binding|negative regulation of neuron projection development|potassium channel regulator activity|actin cytoskeleton|membrane|negative regulation of transcription by RNA polymerase I|kinase binding|formation of radial glial scaffolds|cerebral cortex development|Z disc|platelet activation|regulation of cell migration|cortical cytoskeleton|small GTPase binding|Myb complex|actin cytoskeleton reorganization|mu-type opioid receptor binding|positive regulation of actin filament bundle assembly|actin filament bundle|cell junction assembly|protein localization to cell surface|Fc-gamma receptor I complex binding|negative regulation of protein catabolic process|positive regulation of protein import into nucleus|mRNA transcription by RNA polymerase II|protein homodimerization activity|negative regulation of apoptotic process|receptor clustering|positive regulation of I-kappaB kinase/NF-kappaB signaling|dendritic shaft|perikaryon|negative regulation of DNA-binding transcription factor activity|axonal growth cone|wound healing, spreading of cells|ion channel binding|early endosome to late endosome transport|establishment of protein localization|cell-cell junction organization|cadherin binding|SMAD binding|perinuclear region of cytoplasm|positive regulation of axon regeneration|synapse organization|protein stabilization|actin filament binding|GTPase binding|cytoplasmic sequestering of protein|defense response to virus|actin crosslink formation|cilium assembly|extracellular exosome|platelet aggregation|semaphorin-plexin signaling pathway|protein localization to plasma membrane|tubulin deacetylation|mitotic spindle assembly|establishment of Sertoli cell barrier|apical dendrite|postsynapse|glutamatergic synapse|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of potassium ion transmembrane transport|protein localization to bicellular tight junction|regulation of membrane repolarization during atrial cardiac muscle cell action potential|regulation of membrane repolarization during cardiac muscle cell action potential|positive regulation of neural precursor cell proliferation|positive regulation of integrin-mediated signaling pathway|positive regulation of neuron migration" "hsa04010,hsa04510,hsa05132,hsa05205" MAPK signaling pathway|Focal adhesion|Salmonella infection|Proteoglycans in cancer FLNB 13354.68097 12994.48126 13714.88068 1.055438874 0.077843028 0.822056909 1 69.26898581 76.25842741 2317 filamin B "GO:0003723,GO:0003779,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0005938,GO:0007165,GO:0007517,GO:0015629,GO:0016021,GO:0030018,GO:0030036,GO:0030154,GO:0042802,GO:0043005,GO:0043025,GO:0045296,GO:0070062" RNA binding|actin binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|cell cortex|signal transduction|muscle organ development|actin cytoskeleton|integral component of membrane|Z disc|actin cytoskeleton organization|cell differentiation|identical protein binding|neuron projection|neuronal cell body|cadherin binding|extracellular exosome "hsa04010,hsa04510,hsa05132,hsa05205" MAPK signaling pathway|Focal adhesion|Salmonella infection|Proteoglycans in cancer FLNC 6752.866745 6996.09149 6509.642 0.930468392 -0.103970952 0.750556061 1 38.68624885 37.54690775 2318 filamin C "GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0008092,GO:0016528,GO:0030018,GO:0030506,GO:0034329,GO:0042383,GO:0043034,GO:0048747" actin binding|protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|cytoskeletal protein binding|sarcoplasm|Z disc|ankyrin binding|cell junction assembly|sarcolemma|costamere|muscle fiber development "hsa04010,hsa04510,hsa05132,hsa05205" MAPK signaling pathway|Focal adhesion|Salmonella infection|Proteoglycans in cancer FLOT1 3396.111195 3193.051477 3599.170914 1.127188503 0.172728802 0.587364703 1 80.65675455 94.83163168 10211 flotillin 1 "GO:0001765,GO:0001819,GO:0001931,GO:0001934,GO:0002020,GO:0002090,GO:0005515,GO:0005765,GO:0005768,GO:0005769,GO:0005815,GO:0005886,GO:0005901,GO:0005911,GO:0005912,GO:0005925,GO:0007409,GO:0008180,GO:0009897,GO:0016020,GO:0016323,GO:0016324,GO:0016600,GO:0022617,GO:0030027,GO:0030864,GO:0031410,GO:0032092,GO:0032226,GO:0032728,GO:0033227,GO:0034116,GO:0034141,GO:0034143,GO:0034451,GO:0034976,GO:0035023,GO:0035255,GO:0042383,GO:0042470,GO:0044291,GO:0044854,GO:0045121,GO:0045807,GO:0048643,GO:0048786,GO:0050821,GO:0051092,GO:0051580,GO:0060355,GO:0070062,GO:0070528,GO:0071360,GO:0072659,GO:0098691,GO:0098978,GO:0098982,GO:1901741,GO:1901890,GO:1903044,GO:2000049" "membrane raft assembly|positive regulation of cytokine production|uropod|positive regulation of protein phosphorylation|protease binding|regulation of receptor internalization|protein binding|lysosomal membrane|endosome|early endosome|microtubule organizing center|plasma membrane|caveola|cell-cell junction|adherens junction|focal adhesion|axonogenesis|COP9 signalosome|external side of plasma membrane|membrane|basolateral plasma membrane|apical plasma membrane|flotillin complex|extracellular matrix disassembly|lamellipodium|cortical actin cytoskeleton|cytoplasmic vesicle|positive regulation of protein binding|positive regulation of synaptic transmission, dopaminergic|positive regulation of interferon-beta production|dsRNA transport|positive regulation of heterotypic cell-cell adhesion|positive regulation of toll-like receptor 3 signaling pathway|regulation of toll-like receptor 4 signaling pathway|centriolar satellite|response to endoplasmic reticulum stress|regulation of Rho protein signal transduction|ionotropic glutamate receptor binding|sarcolemma|melanosome|cell-cell contact zone|plasma membrane raft assembly|membrane raft|positive regulation of endocytosis|positive regulation of skeletal muscle tissue development|presynaptic active zone|protein stabilization|positive regulation of NF-kappaB transcription factor activity|regulation of neurotransmitter uptake|positive regulation of cell adhesion molecule production|extracellular exosome|protein kinase C signaling|cellular response to exogenous dsRNA|protein localization to plasma membrane|dopaminergic synapse|glutamatergic synapse|GABA-ergic synapse|positive regulation of myoblast fusion|positive regulation of cell junction assembly|protein localization to membrane raft|positive regulation of cell-cell adhesion mediated by cadherin" hsa04910 Insulin signaling pathway FLOT2 2483.960473 2701.812788 2266.108158 0.838736188 -0.253710991 0.426719265 1 48.59278632 42.51215431 2319 flotillin 2 "GO:0001765,GO:0001931,GO:0005515,GO:0005768,GO:0005886,GO:0005901,GO:0005912,GO:0005925,GO:0007155,GO:0008544,GO:0010629,GO:0016020,GO:0016323,GO:0016324,GO:0016600,GO:0030027,GO:0030139,GO:0030864,GO:0031410,GO:0031982,GO:0034114,GO:0034139,GO:0043231,GO:0044291,GO:0044860,GO:0045661,GO:0048471,GO:0050821,GO:0051092,GO:0070062,GO:0072659,GO:1902992,GO:1903905" membrane raft assembly|uropod|protein binding|endosome|plasma membrane|caveola|adherens junction|focal adhesion|cell adhesion|epidermis development|negative regulation of gene expression|membrane|basolateral plasma membrane|apical plasma membrane|flotillin complex|lamellipodium|endocytic vesicle|cortical actin cytoskeleton|cytoplasmic vesicle|vesicle|regulation of heterotypic cell-cell adhesion|regulation of toll-like receptor 3 signaling pathway|intracellular membrane-bounded organelle|cell-cell contact zone|protein localization to plasma membrane raft|regulation of myoblast differentiation|perinuclear region of cytoplasm|protein stabilization|positive regulation of NF-kappaB transcription factor activity|extracellular exosome|protein localization to plasma membrane|negative regulation of amyloid precursor protein catabolic process|positive regulation of establishment of T cell polarity hsa04910 Insulin signaling pathway FLRT1 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.004107714 0.016637259 23769 fibronectin leucine rich transmembrane protein 1 "GO:0005615,GO:0005789,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0007155,GO:0008543,GO:0016358,GO:0030659,GO:0030674,GO:0031012,GO:0031410,GO:0032809,GO:0044306,GO:0048471,GO:1990138" extracellular space|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|cell adhesion|fibroblast growth factor receptor signaling pathway|dendrite development|cytoplasmic vesicle membrane|protein-macromolecule adaptor activity|extracellular matrix|cytoplasmic vesicle|neuronal cell body membrane|neuron projection terminus|perinuclear region of cytoplasm|neuron projection extension FLRT2 158.9702617 191.826678 126.1138453 0.657436424 -0.605076705 0.298625116 1 0.462437266 0.317119185 23768 fibronectin leucine rich transmembrane protein 2 "GO:0003007,GO:0005104,GO:0005615,GO:0005789,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0007411,GO:0008150,GO:0008543,GO:0030674,GO:0031012,GO:0043005,GO:0045202,GO:0045499,GO:0050919,GO:0051965,GO:0061343,GO:0070062,GO:0071711,GO:2001222" heart morphogenesis|fibroblast growth factor receptor binding|extracellular space|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|axon guidance|biological_process|fibroblast growth factor receptor signaling pathway|protein-macromolecule adaptor activity|extracellular matrix|neuron projection|synapse|chemorepellent activity|negative chemotaxis|positive regulation of synapse assembly|cell adhesion involved in heart morphogenesis|extracellular exosome|basement membrane organization|regulation of neuron migration FLT3LG 103.3852158 96.420817 110.3496147 1.144458407 0.194665032 0.782542126 1 3.44141947 4.1082187 2323 fms related receptor tyrosine kinase 3 ligand "GO:0000165,GO:0005102,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007165,GO:0008284,GO:0009986,GO:0016020,GO:0016021,GO:0019221,GO:0030971,GO:0032819,GO:0035162" MAPK cascade|signaling receptor binding|cytokine activity|protein binding|extracellular region|extracellular space|plasma membrane|signal transduction|positive regulation of cell population proliferation|cell surface|membrane|integral component of membrane|cytokine-mediated signaling pathway|receptor tyrosine kinase binding|positive regulation of natural killer cell proliferation|embryonic hemopoiesis "hsa04010,hsa04014,hsa04151,hsa04640,hsa05200" MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Hematopoietic cell lineage|Pathways in cancer FLVCR1 279.9390576 311.5914823 248.286633 0.796833826 -0.327649203 0.499943104 1 5.295640721 4.401515186 28982 FLVCR heme transporter 1 "GO:0001568,GO:0001701,GO:0005515,GO:0005739,GO:0005886,GO:0006839,GO:0006879,GO:0015232,GO:0015886,GO:0016021,GO:0020037,GO:0030218,GO:0031966,GO:0035264,GO:0042733,GO:0043249,GO:0046620,GO:0048536,GO:0048704,GO:0055085,GO:0060323,GO:0097037" blood vessel development|in utero embryonic development|protein binding|mitochondrion|plasma membrane|mitochondrial transport|cellular iron ion homeostasis|heme transmembrane transporter activity|heme transport|integral component of membrane|heme binding|erythrocyte differentiation|mitochondrial membrane|multicellular organism growth|embryonic digit morphogenesis|erythrocyte maturation|regulation of organ growth|spleen development|embryonic skeletal system morphogenesis|transmembrane transport|head morphogenesis|heme export FLVCR2 39.54146704 42.62815067 36.45478341 0.855180974 -0.225698338 0.827515647 1 0.581304644 0.518534614 55640 FLVCR heme transporter 2 "GO:0005886,GO:0015232,GO:0016021,GO:0020037,GO:0055085,GO:0097037" plasma membrane|heme transmembrane transporter activity|integral component of membrane|heme binding|transmembrane transport|heme export FLYWCH1 791.6594665 740.9178569 842.4010761 1.136969596 0.185193675 0.616441975 1 7.109677084 8.431690502 84256 FLYWCH-type zinc finger 1 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0016604,GO:0046872" DNA binding|protein binding|nucleoplasm|cytosol|nuclear body|metal ion binding FLYWCH2 303.0630799 309.5615704 296.5645894 0.958014876 -0.061880037 0.90242019 1 11.19072196 11.18269006 114984 FLYWCH family member 2 "GO:0003723,GO:0005575,GO:0008150" RNA binding|cellular_component|biological_process FMN1 28.07731427 33.49354696 22.66108158 0.676580525 -0.563666445 0.590620908 1 0.066475821 0.04691364 342184 formin 1 "GO:0003779,GO:0005634,GO:0005737,GO:0005789,GO:0005884,GO:0005886,GO:0005912,GO:0008017,GO:0010467,GO:0017124,GO:0035136,GO:0035137,GO:0045010,GO:0048705,GO:0051127,GO:0051894,GO:0072092" actin binding|nucleus|cytoplasm|endoplasmic reticulum membrane|actin filament|plasma membrane|adherens junction|microtubule binding|gene expression|SH3 domain binding|forelimb morphogenesis|hindlimb morphogenesis|actin nucleation|skeletal system morphogenesis|positive regulation of actin nucleation|positive regulation of focal adhesion assembly|ureteric bud invasion FMNL1 1177.847737 1176.333967 1179.361507 1.002573707 0.003708305 0.994199034 1 9.462701015 9.895719101 752 formin like 1 "GO:0003674,GO:0005515,GO:0005829,GO:0005886,GO:0005938,GO:0008360,GO:0016020,GO:0016477,GO:0030866,GO:0031267,GO:0032059,GO:0032794,GO:0045335,GO:0051014,GO:0051015,GO:0070062" molecular_function|protein binding|cytosol|plasma membrane|cell cortex|regulation of cell shape|membrane|cell migration|cortical actin cytoskeleton organization|small GTPase binding|bleb|GTPase activating protein binding|phagocytic vesicle|actin filament severing|actin filament binding|extracellular exosome FMNL2 1831.706519 1892.892881 1770.520157 0.935351479 -0.096419503 0.767503713 1 13.7821085 13.44641255 114793 formin like 2 "GO:0005829,GO:0007010,GO:0008360,GO:0016477,GO:0022604,GO:0030866,GO:0045296,GO:0051015" cytosol|cytoskeleton organization|regulation of cell shape|cell migration|regulation of cell morphogenesis|cortical actin cytoskeleton organization|cadherin binding|actin filament binding FMNL3 1643.57248 1626.974417 1660.170542 1.020403593 0.029139885 0.93109428 1 5.939631991 6.321897452 91010 formin like 3 "GO:0001525,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0007010,GO:0008360,GO:0016477,GO:0030866,GO:0032794,GO:0043231,GO:0051015" angiogenesis|cytoplasm|Golgi apparatus|cytosol|plasma membrane|cytoskeleton organization|regulation of cell shape|cell migration|cortical actin cytoskeleton organization|GTPase activating protein binding|intracellular membrane-bounded organelle|actin filament binding FMO3 8.015727316 9.134603715 6.896850916 0.755024644 -0.405404361 0.864587159 1 0.20858226 0.164268551 2328 flavin containing dimethylaniline monoxygenase 3 "GO:0004497,GO:0004499,GO:0005515,GO:0005789,GO:0006805,GO:0016021,GO:0034899,GO:0043231,GO:0050660,GO:0050661,GO:0055114" "monooxygenase activity|N,N-dimethylaniline monooxygenase activity|protein binding|endoplasmic reticulum membrane|xenobiotic metabolic process|integral component of membrane|trimethylamine monooxygenase activity|intracellular membrane-bounded organelle|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process" hsa00982 Drug metabolism - cytochrome P450 FMO4 33.37750235 25.37389921 41.38110549 1.63085323 0.705626952 0.469281137 1 0.383726032 0.652757801 2329 flavin containing dimethylaniline monoxygenase 4 "GO:0004497,GO:0004499,GO:0005515,GO:0005789,GO:0016021,GO:0042737,GO:0050660,GO:0050661,GO:0055114" "monooxygenase activity|N,N-dimethylaniline monooxygenase activity|protein binding|endoplasmic reticulum membrane|integral component of membrane|drug catabolic process|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process" hsa00982 Drug metabolism - cytochrome P450 FMO5 114.8048313 102.5105528 127.0991097 1.239863665 0.310181491 0.638734251 1 0.664592661 0.859499055 2330 flavin containing dimethylaniline monoxygenase 5 "GO:0004031,GO:0004497,GO:0004499,GO:0005783,GO:0005789,GO:0005829,GO:0016021,GO:0016174,GO:0017144,GO:0050660,GO:0050661,GO:0055114,GO:0070995,GO:0090181" "aldehyde oxidase activity|monooxygenase activity|N,N-dimethylaniline monooxygenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|integral component of membrane|NAD(P)H oxidase H2O2-forming activity|drug metabolic process|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process|NADPH oxidation|regulation of cholesterol metabolic process" hsa00982 Drug metabolism - cytochrome P450 FMOD 9.374857733 1.014955968 17.7347595 17.47342747 4.12709072 0.021809424 0.642619421 0.01746651 0.318346567 2331 fibromodulin "GO:0005576,GO:0005615,GO:0005796,GO:0007181,GO:0018146,GO:0030021,GO:0030199,GO:0031012,GO:0042340,GO:0043202,GO:0062023" extracellular region|extracellular space|Golgi lumen|transforming growth factor beta receptor complex assembly|keratan sulfate biosynthetic process|extracellular matrix structural constituent conferring compression resistance|collagen fibril organization|extracellular matrix|keratan sulfate catabolic process|lysosomal lumen|collagen-containing extracellular matrix hsa04350 TGF-beta signaling pathway FMR1 1182.263859 1208.812558 1155.715161 0.956074747 -0.064804681 0.852206409 1 13.7856545 13.74786209 2332 FMRP translational regulator 1 "GO:0000381,GO:0000775,GO:0001934,GO:0002092,GO:0002151,GO:0003682,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0005844,GO:0005845,GO:0006397,GO:0006974,GO:0007215,GO:0007399,GO:0008017,GO:0008266,GO:0008380,GO:0010369,GO:0010494,GO:0014069,GO:0015030,GO:0016020,GO:0016032,GO:0017148,GO:0019897,GO:0030371,GO:0030424,GO:0030425,GO:0030426,GO:0031047,GO:0031369,GO:0032433,GO:0032797,GO:0033129,GO:0033592,GO:0034046,GO:0034644,GO:0035064,GO:0035197,GO:0035198,GO:0035613,GO:0036464,GO:0042734,GO:0042788,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043022,GO:0043025,GO:0043197,GO:0043204,GO:0043488,GO:0043679,GO:0044325,GO:0044326,GO:0044830,GO:0045182,GO:0045202,GO:0045211,GO:0045727,GO:0045947,GO:0046928,GO:0046982,GO:0048027,GO:0048471,GO:0051028,GO:0051489,GO:0051491,GO:0060964,GO:0060998,GO:0060999,GO:0070840,GO:0071598,GO:0072711,GO:0097386,GO:0098586,GO:0098793,GO:0098794,GO:0098908,GO:1900453,GO:1901254,GO:1901386,GO:1901800,GO:1902373,GO:1902416,GO:1902737,GO:1990124,GO:1990812,GO:1990825,GO:1990904,GO:2000301,GO:2000637,GO:2000766,GO:2001022" "regulation of alternative mRNA splicing, via spliceosome|chromosome, centromeric region|positive regulation of protein phosphorylation|positive regulation of receptor internalization|G-quadruplex RNA binding|chromatin binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytoplasm|cytosol|polysome|mRNA cap binding complex|mRNA processing|cellular response to DNA damage stimulus|glutamate receptor signaling pathway|nervous system development|microtubule binding|poly(U) RNA binding|RNA splicing|chromocenter|cytoplasmic stress granule|postsynaptic density|Cajal body|membrane|viral process|negative regulation of translation|extrinsic component of plasma membrane|translation repressor activity|axon|dendrite|growth cone|gene silencing by RNA|translation initiation factor binding|filopodium tip|SMN complex|positive regulation of histone phosphorylation|RNA strand annealing activity|poly(G) binding|cellular response to UV|methylated histone binding|siRNA binding|miRNA binding|RNA stem-loop binding|cytoplasmic ribonucleoprotein granule|presynaptic membrane|polysomal ribosome|identical protein binding|protein homodimerization activity|cell projection|neuron projection|ribosome binding|neuronal cell body|dendritic spine|perikaryon|regulation of mRNA stability|axon terminus|ion channel binding|dendritic spine neck|modulation by host of viral RNA genome replication|translation regulator activity|synapse|postsynaptic membrane|positive regulation of translation|negative regulation of translational initiation|regulation of neurotransmitter secretion|protein heterodimerization activity|mRNA 5'-UTR binding|perinuclear region of cytoplasm|mRNA transport|regulation of filopodium assembly|positive regulation of filopodium assembly|regulation of gene silencing by miRNA|regulation of dendritic spine development|positive regulation of dendritic spine development|dynein complex binding|neuronal ribonucleoprotein granule|cellular response to hydroxyurea|glial cell projection|cellular response to virus|presynapse|postsynapse|regulation of neuronal action potential|negative regulation of long-term synaptic depression|positive regulation of intracellular transport of viral material|negative regulation of voltage-gated calcium channel activity|positive regulation of proteasomal protein catabolic process|negative regulation of mRNA catabolic process|positive regulation of mRNA binding|dendritic filopodium|messenger ribonucleoprotein complex|growth cone filopodium|sequence-specific mRNA binding|ribonucleoprotein complex|negative regulation of synaptic vesicle exocytosis|positive regulation of gene silencing by miRNA|negative regulation of cytoplasmic translation|positive regulation of response to DNA damage stimulus" hsa03013 RNA transport FN1 757498.0306 950044.4594 564951.6017 0.594658067 -0.749867749 0.387965052 1 5535.711035 3433.654995 2335 fibronectin 1 "GO:0001525,GO:0001932,GO:0002020,GO:0002576,GO:0005102,GO:0005178,GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005577,GO:0005604,GO:0005615,GO:0005788,GO:0005793,GO:0006953,GO:0007044,GO:0007155,GO:0007160,GO:0007161,GO:0007229,GO:0007399,GO:0007507,GO:0008022,GO:0008201,GO:0008284,GO:0008360,GO:0009611,GO:0010628,GO:0010952,GO:0014068,GO:0016324,GO:0016504,GO:0018149,GO:0019221,GO:0019899,GO:0030198,GO:0031012,GO:0031093,GO:0033622,GO:0034446,GO:0035987,GO:0042802,GO:0043394,GO:0043687,GO:0044267,GO:0045773,GO:0048146,GO:0050900,GO:0051087,GO:0051702,GO:0062023,GO:0070062,GO:0070372,GO:0070527,GO:0071635,GO:0072378,GO:0072562,GO:0097718,GO:1901166,GO:1904237" "angiogenesis|regulation of protein phosphorylation|protease binding|platelet degranulation|signaling receptor binding|integrin binding|extracellular matrix structural constituent|protein binding|collagen binding|extracellular region|fibrinogen complex|basement membrane|extracellular space|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|acute-phase response|cell-substrate junction assembly|cell adhesion|cell-matrix adhesion|calcium-independent cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development|heart development|protein C-terminus binding|heparin binding|positive regulation of cell population proliferation|regulation of cell shape|response to wounding|positive regulation of gene expression|positive regulation of peptidase activity|positive regulation of phosphatidylinositol 3-kinase signaling|apical plasma membrane|peptidase activator activity|peptide cross-linking|cytokine-mediated signaling pathway|enzyme binding|extracellular matrix organization|extracellular matrix|platelet alpha granule lumen|integrin activation|substrate adhesion-dependent cell spreading|endodermal cell differentiation|identical protein binding|proteoglycan binding|post-translational protein modification|cellular protein metabolic process|positive regulation of axon extension|positive regulation of fibroblast proliferation|leukocyte migration|chaperone binding|biological process involved in interaction with symbiont|collagen-containing extracellular matrix|extracellular exosome|regulation of ERK1 and ERK2 cascade|platelet aggregation|negative regulation of transforming growth factor beta production|blood coagulation, fibrin clot formation|blood microparticle|disordered domain specific binding|neural crest cell migration involved in autonomic nervous system development|positive regulation of substrate-dependent cell migration, cell attachment to substrate" "hsa04151,hsa04510,hsa04512,hsa04810,hsa04933,hsa05100,hsa05135,hsa05146,hsa05165,hsa05200,hsa05205,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|AGE-RAGE signaling pathway in diabetic complications|Bacterial invasion of epithelial cells|Yersinia infection|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer FN3K 233.1174711 209.0809295 257.1540127 1.22992572 0.298571188 0.563643631 1 5.902570505 7.572442713 64122 fructosamine 3 kinase "GO:0005524,GO:0005575,GO:0005829,GO:0016301,GO:0016310,GO:0018215,GO:0030387,GO:0030389,GO:0030393,GO:0030855,GO:0036525,GO:0043687,GO:0102193,GO:0102194" ATP binding|cellular_component|cytosol|kinase activity|phosphorylation|protein phosphopantetheinylation|fructosamine-3-kinase activity|fructosamine metabolic process|fructoselysine metabolic process|epithelial cell differentiation|protein deglycation|post-translational protein modification|protein-ribulosamine 3-kinase activity|protein-fructosamine 3-kinase activity FN3KRP 841.5719421 650.5867757 1032.557109 1.587116657 0.666408174 0.067429654 1 15.89480225 26.31357818 79672 fructosamine 3 kinase related protein "GO:0005524,GO:0005829,GO:0016301,GO:0016310,GO:0018215,GO:0043687,GO:0102193" ATP binding|cytosol|kinase activity|phosphorylation|protein phosphopantetheinylation|post-translational protein modification|protein-ribulosamine 3-kinase activity FNBP1 1191.498424 1099.197314 1283.799535 1.167942751 0.22396956 0.513692724 1 8.481180105 10.33222301 23048 formin binding protein 1 "GO:0005515,GO:0005764,GO:0005829,GO:0005856,GO:0005886,GO:0005905,GO:0005938,GO:0006897,GO:0007165,GO:0008289,GO:0031410,GO:0042802,GO:0043231,GO:0061024" protein binding|lysosome|cytosol|cytoskeleton|plasma membrane|clathrin-coated pit|cell cortex|endocytosis|signal transduction|lipid binding|cytoplasmic vesicle|identical protein binding|intracellular membrane-bounded organelle|membrane organization hsa05131 Shigellosis FNBP1L 788.6334038 870.8322209 706.4345867 0.811217787 -0.30183881 0.413119712 1 8.895639346 7.527149834 54874 formin binding protein 1 like "GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0006900,GO:0006914,GO:0007165,GO:0008289,GO:0010324,GO:0016050,GO:0030050,GO:0031410,GO:0045296,GO:0051020,GO:0051491,GO:0060271,GO:0061024,GO:0072583,GO:0097320" protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|cell cortex|vesicle budding from membrane|autophagy|signal transduction|lipid binding|membrane invagination|vesicle organization|vesicle transport along actin filament|cytoplasmic vesicle|cadherin binding|GTPase binding|positive regulation of filopodium assembly|cilium assembly|membrane organization|clathrin-dependent endocytosis|plasma membrane tubulation hsa05131 Shigellosis FNBP4 1677.373828 1580.286443 1774.461214 1.122873149 0.167194956 0.610165479 1 13.81120508 16.17626304 23360 formin binding protein 4 "GO:0005515,GO:0016607" protein binding|nuclear speck FNDC10 397.9669061 432.3712425 363.5625697 0.840857425 -0.250066895 0.566925251 1 10.30982962 9.042526322 643988 fibronectin type III domain containing 10 GO:0016021 integral component of membrane FNDC11 94.29514944 81.19647747 107.3938214 1.322641385 0.403421949 0.565430724 1 2.029770553 2.800302736 79025 fibronectin type III domain containing 11 GO:0005515 protein binding FNDC3A 1528.77037 1490.970318 1566.570422 1.050705305 0.071358088 0.830798403 1 9.138616333 10.01560756 22862 fibronectin type III domain containing 3A "GO:0000139,GO:0003723,GO:0005794,GO:0016020,GO:0016021" Golgi membrane|RNA binding|Golgi apparatus|membrane|integral component of membrane FNDC3B 3817.232807 4164.364338 3470.101275 0.833284745 -0.263118526 0.408772107 1 18.1929063 15.81289706 64778 fibronectin type III domain containing 3B "GO:0003723,GO:0016021" RNA binding|integral component of membrane FNDC4 446.2557489 298.3970547 594.1144432 1.991019797 0.993507566 0.018921434 0.592288939 9.375160136 19.47019058 64838 fibronectin type III domain containing 4 "GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0016021,GO:0050728,GO:0071559" extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|integral component of membrane|negative regulation of inflammatory response|response to transforming growth factor beta FNDC5 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.052776118 0.017813027 252995 fibronectin type III domain containing 5 "GO:0003674,GO:0005179,GO:0005576,GO:0005778,GO:0005783,GO:0005886,GO:0007165,GO:0008150,GO:0014850,GO:0016021,GO:0090336" molecular_function|hormone activity|extracellular region|peroxisomal membrane|endoplasmic reticulum|plasma membrane|signal transduction|biological_process|response to muscle activity|integral component of membrane|positive regulation of brown fat cell differentiation FNIP1 1078.593852 1126.601125 1030.58658 0.914775032 -0.128511106 0.713435669 1 8.540394038 8.149071731 96459 folliculin interacting protein 1 "GO:0000122,GO:0001932,GO:0001934,GO:0002327,GO:0002904,GO:0005085,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0009267,GO:0010823,GO:0019899,GO:0031334,GO:0031929,GO:0032007,GO:0032008,GO:0033138,GO:0042030,GO:0043154,GO:0051087,GO:1904262,GO:2000973" negative regulation of transcription by RNA polymerase II|regulation of protein phosphorylation|positive regulation of protein phosphorylation|immature B cell differentiation|positive regulation of B cell apoptotic process|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|lysosomal membrane|cytosol|cellular response to starvation|negative regulation of mitochondrion organization|enzyme binding|positive regulation of protein-containing complex assembly|TOR signaling|negative regulation of TOR signaling|positive regulation of TOR signaling|positive regulation of peptidyl-serine phosphorylation|ATPase inhibitor activity|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|chaperone binding|negative regulation of TORC1 signaling|regulation of pro-B cell differentiation hsa04150 mTOR signaling pathway FNIP2 206.5841175 281.1428032 132.0254318 0.469602744 -1.090487257 0.042090249 0.939853769 1.143961691 0.560348272 57600 folliculin interacting protein 2 "GO:0000122,GO:0001932,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0006468,GO:0008630,GO:0031334,GO:0033138,GO:0034451,GO:0042030,GO:0043086,GO:0051087" negative regulation of transcription by RNA polymerase II|regulation of protein phosphorylation|protein binding|cytoplasm|lysosomal membrane|cytosol|protein phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of protein-containing complex assembly|positive regulation of peptidyl-serine phosphorylation|centriolar satellite|ATPase inhibitor activity|negative regulation of catalytic activity|chaperone binding hsa04150 mTOR signaling pathway FNTA 822.0069468 761.2169763 882.7969172 1.159717853 0.213773855 0.559667385 1 23.12714723 27.97630395 2339 "farnesyltransferase, CAAX box, alpha" "GO:0004660,GO:0004661,GO:0004662,GO:0004663,GO:0005515,GO:0005737,GO:0005829,GO:0005875,GO:0005886,GO:0005953,GO:0005965,GO:0007179,GO:0008017,GO:0018215,GO:0018343,GO:0018344,GO:0022400,GO:0030548,GO:0030971,GO:0043014,GO:0045213,GO:0071340,GO:0090044,GO:0090045,GO:0099601" protein farnesyltransferase activity|protein geranylgeranyltransferase activity|CAAX-protein geranylgeranyltransferase activity|Rab geranylgeranyltransferase activity|protein binding|cytoplasm|cytosol|microtubule associated complex|plasma membrane|CAAX-protein geranylgeranyltransferase complex|protein farnesyltransferase complex|transforming growth factor beta receptor signaling pathway|microtubule binding|protein phosphopantetheinylation|protein farnesylation|protein geranylgeranylation|regulation of rhodopsin mediated signaling pathway|acetylcholine receptor regulator activity|receptor tyrosine kinase binding|alpha-tubulin binding|neurotransmitter receptor metabolic process|skeletal muscle acetylcholine-gated channel clustering|positive regulation of tubulin deacetylation|positive regulation of deacetylase activity|regulation of neurotransmitter receptor activity hsa00900 Terpenoid backbone biosynthesis FNTB 51.96119268 49.73284245 54.18954291 1.089612824 0.123815588 0.905147904 1 0.929101078 1.055968832 2342 "farnesyltransferase, CAAX box, beta" "GO:0004660,GO:0005515,GO:0005829,GO:0005875,GO:0005965,GO:0008270,GO:0018215,GO:0018342,GO:0018343,GO:0022400" protein farnesyltransferase activity|protein binding|cytosol|microtubule associated complex|protein farnesyltransferase complex|zinc ion binding|protein phosphopantetheinylation|protein prenylation|protein farnesylation|regulation of rhodopsin mediated signaling pathway hsa00900 Terpenoid backbone biosynthesis FOCAD 1005.799092 999.7316288 1011.866556 1.012138184 0.017406271 0.963628845 1 6.626472996 6.995812672 54914 focadhesin "GO:0005515,GO:0005925,GO:0016021" protein binding|focal adhesion|integral component of membrane FOS 43.90092804 37.55337083 50.24848524 1.338055257 0.420137695 0.647567205 1 0.903966612 1.261660099 2353 "Fos proto-oncogene, AP-1 transcription factor subunit" "GO:0000785,GO:0000976,GO:0000978,GO:0000979,GO:0000981,GO:0001102,GO:0001228,GO:0001661,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0006306,GO:0006357,GO:0006366,GO:0006954,GO:0007179,GO:0007399,GO:0007565,GO:0007568,GO:0008134,GO:0009409,GO:0009416,GO:0009629,GO:0009636,GO:0016020,GO:0019221,GO:0030431,GO:0031668,GO:0032496,GO:0032570,GO:0032870,GO:0032993,GO:0034614,GO:0035902,GO:0035914,GO:0035976,GO:0035994,GO:0038095,GO:0042493,GO:0043005,GO:0044877,GO:0045672,GO:0045893,GO:0045944,GO:0051090,GO:0051412,GO:0051591,GO:0060395,GO:0070412,GO:0071276,GO:0071277,GO:1901216,GO:1902895,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|conditioned taste aversion|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|DNA methylation|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|inflammatory response|transforming growth factor beta receptor signaling pathway|nervous system development|female pregnancy|aging|transcription factor binding|response to cold|response to light stimulus|response to gravity|response to toxic substance|membrane|cytokine-mediated signaling pathway|sleep|cellular response to extracellular stimulus|response to lipopolysaccharide|response to progesterone|cellular response to hormone stimulus|protein-DNA complex|cellular response to reactive oxygen species|response to immobilization stress|skeletal muscle cell differentiation|transcription factor AP-1 complex|response to muscle stretch|Fc-epsilon receptor signaling pathway|response to drug|neuron projection|protein-containing complex binding|positive regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of DNA-binding transcription factor activity|response to corticosterone|response to cAMP|SMAD protein signal transduction|R-SMAD binding|cellular response to cadmium ion|cellular response to calcium ion|positive regulation of neuron death|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa01522,hsa04010,hsa04024,hsa04210,hsa04380,hsa04620,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04713,hsa04725,hsa04728,hsa04915,hsa04917,hsa04921,hsa04926,hsa04928,hsa04932,hsa04935,hsa05031,hsa05130,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05161,hsa05162,hsa05166,hsa05167,hsa05170,hsa05171,hsa05200,hsa05210,hsa05224,hsa05231,hsa05235,hsa05323,hsa05418" "Endocrine resistance|MAPK signaling pathway|cAMP signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Circadian entrainment|Cholinergic synapse|Dopaminergic synapse|Estrogen signaling pathway|Prolactin signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Non-alcoholic fatty liver disease|Growth hormone synthesis, secretion and action|Amphetamine addiction|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Colorectal cancer|Breast cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Rheumatoid arthritis|Fluid shear stress and atherosclerosis" TF_bZIP FOSB 471.823881 530.8219715 412.8257905 0.777710443 -0.362694984 0.382429319 1 7.121658338 5.777167972 2354 "FosB proto-oncogene, AP-1 transcription factor subunit" "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0007565,GO:0008134,GO:0009612,GO:0032570,GO:0032870,GO:0042493,GO:0043231,GO:0043278,GO:0045944,GO:0051412,GO:0051591,GO:0071277,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|female pregnancy|transcription factor binding|response to mechanical stimulus|response to progesterone|cellular response to hormone stimulus|response to drug|intracellular membrane-bounded organelle|response to morphine|positive regulation of transcription by RNA polymerase II|response to corticosterone|response to cAMP|cellular response to calcium ion|sequence-specific double-stranded DNA binding" "hsa04380,hsa04657,hsa05030,hsa05031,hsa05034" Osteoclast differentiation|IL-17 signaling pathway|Cocaine addiction|Amphetamine addiction|Alcoholism FOSL1 8010.605516 6763.666573 9257.544458 1.368716858 0.452824031 0.171373237 1 201.2666576 287.3435019 8061 "FOS like 1, AP-1 transcription factor subunit" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001701,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006935,GO:0006968,GO:0007296,GO:0007565,GO:0007612,GO:0008284,GO:0008285,GO:0009612,GO:0009615,GO:0009629,GO:0031668,GO:0032570,GO:0034097,GO:0042493,GO:0042542,GO:0042734,GO:0043005,GO:0043065,GO:0045787,GO:0051091,GO:0051412,GO:0051591,GO:0060674,GO:1902895,GO:1990837,GO:2000144" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|chemotaxis|cellular defense response|vitellogenesis|female pregnancy|learning|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to mechanical stimulus|response to virus|response to gravity|cellular response to extracellular stimulus|response to progesterone|response to cytokine|response to drug|response to hydrogen peroxide|presynaptic membrane|neuron projection|positive regulation of apoptotic process|positive regulation of cell cycle|positive regulation of DNA-binding transcription factor activity|response to corticosterone|response to cAMP|placenta blood vessel development|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding|positive regulation of DNA-templated transcription, initiation" "hsa04310,hsa04380,hsa04657,hsa05166" Wnt signaling pathway|Osteoclast differentiation|IL-17 signaling pathway|Human T-cell leukemia virus 1 infection TF_bZIP FOSL2 2803.713173 3748.232391 1859.193954 0.496018859 -1.011533121 0.001632285 0.125704511 21.60404548 11.17761641 2355 "FOS like 2, AP-1 transcription factor subunit" "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003334,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008219,GO:0045944,GO:0048146" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|keratinocyte development|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell death|positive regulation of transcription by RNA polymerase II|positive regulation of fibroblast proliferation" hsa04380 Osteoclast differentiation TF_bZIP FOXA1 138.626605 148.1835714 129.0696386 0.871011795 -0.199235839 0.751535001 1 1.749003759 1.589024923 3169 forkhead box A1 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005902,GO:0006338,GO:0006357,GO:0007219,GO:0008134,GO:0009653,GO:0010719,GO:0019904,GO:0021904,GO:0030154,GO:0032355,GO:0033148,GO:0042445,GO:0042593,GO:0043065,GO:0045666,GO:0045880,GO:0045931,GO:0045944,GO:0048646,GO:0048665,GO:0051091,GO:0060441,GO:0060487,GO:0060528,GO:0060738,GO:0060740,GO:0060741,GO:0060743,GO:0061144,GO:0071542,GO:1902691,GO:1990837,GO:2000049" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|microvillus|chromatin remodeling|regulation of transcription by RNA polymerase II|Notch signaling pathway|transcription factor binding|anatomical structure morphogenesis|negative regulation of epithelial to mesenchymal transition|protein domain specific binding|dorsal/ventral neural tube patterning|cell differentiation|response to estradiol|positive regulation of intracellular estrogen receptor signaling pathway|hormone metabolic process|glucose homeostasis|positive regulation of apoptotic process|positive regulation of neuron differentiation|positive regulation of smoothened signaling pathway|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|anatomical structure formation involved in morphogenesis|neuron fate specification|positive regulation of DNA-binding transcription factor activity|epithelial tube branching involved in lung morphogenesis|lung epithelial cell differentiation|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|epithelial-mesenchymal signaling involved in prostate gland development|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|epithelial cell maturation involved in prostate gland development|alveolar secondary septum development|dopaminergic neuron differentiation|respiratory basal cell differentiation|sequence-specific double-stranded DNA binding|positive regulation of cell-cell adhesion mediated by cadherin" chromosome_remodelling_factor FOXA2 124.179689 103.5255088 144.8338692 1.399016252 0.484412722 0.445370965 1 1.903849602 2.778250024 3170 forkhead box A2 "GO:0000432,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001708,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006325,GO:0006357,GO:0008134,GO:0008344,GO:0009653,GO:0010719,GO:0019904,GO:0030054,GO:0030154,GO:0030193,GO:0031018,GO:0033132,GO:0040019,GO:0043433,GO:0045893,GO:0045944,GO:0061178,GO:0061987,GO:0070741,GO:0071542,GO:0090009,GO:1990837,GO:2000049,GO:2000543,GO:2000971" "positive regulation of transcription from RNA polymerase II promoter by glucose|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cell fate specification|DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|chromatin organization|regulation of transcription by RNA polymerase II|transcription factor binding|adult locomotory behavior|anatomical structure morphogenesis|negative regulation of epithelial to mesenchymal transition|protein domain specific binding|cell junction|cell differentiation|regulation of blood coagulation|endocrine pancreas development|negative regulation of glucokinase activity|positive regulation of embryonic development|negative regulation of DNA-binding transcription factor activity|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of transcription from RNA polymerase II promoter by glucose|response to interleukin-6|dopaminergic neuron differentiation|primitive streak formation|sequence-specific double-stranded DNA binding|positive regulation of cell-cell adhesion mediated by cadherin|positive regulation of gastrulation|negative regulation of detection of glucose" "hsa04213,hsa04950" Longevity regulating pathway - multiple species|Maturity onset diabetes of the young Fork_head FOXC1 140.0127053 175.5873825 104.4380282 0.594792329 -0.749542054 0.216858065 1 2.232709387 1.385203202 2296 forkhead box C1 "GO:0000122,GO:0000785,GO:0000792,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0001541,GO:0001654,GO:0001657,GO:0001701,GO:0001756,GO:0001822,GO:0001945,GO:0001958,GO:0001974,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0007219,GO:0007507,GO:0008134,GO:0008283,GO:0008301,GO:0008354,GO:0009653,GO:0010718,GO:0014031,GO:0014032,GO:0016477,GO:0016525,GO:0021549,GO:0030154,GO:0030199,GO:0030203,GO:0032808,GO:0035050,GO:0036438,GO:0038084,GO:0042475,GO:0043010,GO:0043388,GO:0043565,GO:0045618,GO:0045893,GO:0045930,GO:0045944,GO:0046620,GO:0048010,GO:0048341,GO:0048844,GO:0055010,GO:0060038,GO:0070098,GO:0071364,GO:0072010,GO:0097746,GO:1901491,GO:1901534,GO:1902038,GO:1902257,GO:1904798,GO:1990841,GO:1990869" "negative regulation of transcription by RNA polymerase II|chromatin|heterochromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|ovarian follicle development|eye development|ureteric bud development|in utero embryonic development|somitogenesis|kidney development|lymph vessel development|endochondral ossification|blood vessel remodeling|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|Notch signaling pathway|heart development|transcription factor binding|cell population proliferation|DNA binding, bending|germ cell migration|anatomical structure morphogenesis|positive regulation of epithelial to mesenchymal transition|mesenchymal cell development|neural crest cell development|cell migration|negative regulation of angiogenesis|cerebellum development|cell differentiation|collagen fibril organization|glycosaminoglycan metabolic process|lacrimal gland development|embryonic heart tube development|maintenance of lens transparency|vascular endothelial growth factor signaling pathway|odontogenesis of dentin-containing tooth|camera-type eye development|positive regulation of DNA binding|sequence-specific DNA binding|positive regulation of keratinocyte differentiation|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|regulation of organ growth|vascular endothelial growth factor receptor signaling pathway|paraxial mesoderm formation|artery morphogenesis|ventricular cardiac muscle tissue morphogenesis|cardiac muscle cell proliferation|chemokine-mediated signaling pathway|cellular response to epidermal growth factor stimulus|glomerular epithelium development|blood vessel diameter maintenance|negative regulation of lymphangiogenesis|positive regulation of hematopoietic progenitor cell differentiation|positive regulation of hematopoietic stem cell differentiation|negative regulation of apoptotic process involved in outflow tract morphogenesis|positive regulation of core promoter binding|promoter-specific chromatin binding|cellular response to chemokine" FOXC2 59.31826265 81.19647747 37.44004783 0.461104336 -1.116834863 0.166498962 1 1.418039703 0.682030076 2303 forkhead box C2 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001216,GO:0001228,GO:0001503,GO:0001569,GO:0001656,GO:0001657,GO:0001756,GO:0001946,GO:0001974,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007219,GO:0007498,GO:0007507,GO:0008286,GO:0009653,GO:0009725,GO:0010595,GO:0014032,GO:0016604,GO:0030154,GO:0030199,GO:0031490,GO:0033630,GO:0035050,GO:0035470,GO:0042802,GO:0043010,GO:0043565,GO:0045893,GO:0045944,GO:0046620,GO:0048010,GO:0048343,GO:0048703,GO:0048844,GO:0055010,GO:0060038,GO:0072011,GO:0072112,GO:0072144,GO:0090050,GO:0097746,GO:0120163,GO:1902257,GO:1990837,GO:1990841" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|ossification|branching involved in blood vessel morphogenesis|metanephros development|ureteric bud development|somitogenesis|lymphangiogenesis|blood vessel remodeling|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|Notch signaling pathway|mesoderm development|heart development|insulin receptor signaling pathway|anatomical structure morphogenesis|response to hormone|positive regulation of endothelial cell migration|neural crest cell development|nuclear body|cell differentiation|collagen fibril organization|chromatin DNA binding|positive regulation of cell adhesion mediated by integrin|embryonic heart tube development|positive regulation of vascular wound healing|identical protein binding|camera-type eye development|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of organ growth|vascular endothelial growth factor receptor signaling pathway|paraxial mesodermal cell fate commitment|embryonic viscerocranium morphogenesis|artery morphogenesis|ventricular cardiac muscle tissue morphogenesis|cardiac muscle cell proliferation|glomerular endothelium development|glomerular visceral epithelial cell differentiation|glomerular mesangial cell development|positive regulation of cell migration involved in sprouting angiogenesis|blood vessel diameter maintenance|negative regulation of cold-induced thermogenesis|negative regulation of apoptotic process involved in outflow tract morphogenesis|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" FOXD1 474.307331 464.8498335 483.7648285 1.040690549 0.057541145 0.894410297 1 9.372215038 10.1737201 2297 forkhead box D1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0006357,GO:0007411,GO:0008301,GO:0009653,GO:0010628,GO:0030154,GO:0030513,GO:0032275,GO:0043565,GO:0045892,GO:0045944,GO:0060678,GO:0072076,GO:0072210,GO:0072213,GO:0072267,GO:0090184" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|axon guidance|DNA binding, bending|anatomical structure morphogenesis|positive regulation of gene expression|cell differentiation|positive regulation of BMP signaling pathway|luteinizing hormone secretion|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|dichotomous subdivision of terminal units involved in ureteric bud branching|nephrogenic mesenchyme development|metanephric nephron development|metanephric capsule development|metanephric capsule specification|positive regulation of kidney development" FOXD2 34.81086165 22.3290313 47.29269199 2.117991208 1.082696601 0.255423883 1 0.427072003 0.943498436 2306 forkhead box D2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0009653,GO:0030154,GO:0043565,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" Fork_head FOXD4 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.094017264 0.095198288 2298 forkhead box D4 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0008301,GO:0009653,GO:0030154,GO:0043565" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|DNA binding, bending|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding" FOXF1 122.3400506 146.1536594 98.52644165 0.674129146 -0.568903093 0.371193484 1 2.102888424 1.478683628 2294 forkhead box F1 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001568,GO:0001570,GO:0001701,GO:0001756,GO:0001763,GO:0002053,GO:0003197,GO:0003214,GO:0003677,GO:0005634,GO:0005667,GO:0006357,GO:0007224,GO:0007368,GO:0007494,GO:0007507,GO:0009887,GO:0010811,GO:0014822,GO:0030198,GO:0030323,GO:0030324,GO:0030335,GO:0031016,GO:0043305,GO:0043565,GO:0045198,GO:0045893,GO:0045944,GO:0048286,GO:0048371,GO:0048557,GO:0048565,GO:0048613,GO:0048617,GO:0050728,GO:0051145,GO:0060426,GO:0060438,GO:0060441,GO:0060461,GO:0060463,GO:0060841,GO:0061030,GO:0071345,GO:0071407,GO:0072189,GO:0090131,GO:0097070,GO:0098609" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blood vessel development|vasculogenesis|in utero embryonic development|somitogenesis|morphogenesis of a branching structure|positive regulation of mesenchymal cell proliferation|endocardial cushion development|cardiac left ventricle morphogenesis|DNA binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|smoothened signaling pathway|determination of left/right symmetry|midgut development|heart development|animal organ morphogenesis|positive regulation of cell-substrate adhesion|detection of wounding|extracellular matrix organization|respiratory tube development|lung development|positive regulation of cell migration|pancreas development|negative regulation of mast cell degranulation|sequence-specific DNA binding|establishment of epithelial cell apical/basal polarity|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lung alveolus development|lateral mesodermal cell differentiation|embryonic digestive tract morphogenesis|digestive tract development|embryonic ectodermal digestive tract morphogenesis|embryonic foregut morphogenesis|negative regulation of inflammatory response|smooth muscle cell differentiation|lung vasculature development|trachea development|epithelial tube branching involved in lung morphogenesis|right lung morphogenesis|lung lobe morphogenesis|venous blood vessel development|epithelial cell differentiation involved in mammary gland alveolus development|cellular response to cytokine stimulus|cellular response to organic cyclic compound|ureter development|mesenchyme migration|ductus arteriosus closure|cell-cell adhesion" FOXF2 174.3188106 163.4079109 185.2297103 1.133541879 0.180837692 0.755673089 1 3.376594949 3.992385466 2295 forkhead box F2 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001837,GO:0003677,GO:0003700,GO:0005634,GO:0005667,GO:0006357,GO:0008134,GO:0009887,GO:0030198,GO:0032434,GO:0042249,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0048566,GO:0048596,GO:0048806,GO:0060021,GO:1902914" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|epithelial to mesenchymal transition|DNA binding|DNA-binding transcription factor activity|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription factor binding|animal organ morphogenesis|extracellular matrix organization|regulation of proteasomal ubiquitin-dependent protein catabolic process|establishment of planar polarity of embryonic epithelium|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic digestive tract development|embryonic camera-type eye morphogenesis|genitalia development|roof of mouth development|regulation of protein polyubiquitination" FOXG1 7.030462899 9.134603715 4.926322083 0.539303317 -0.890831188 0.625563046 1 0.13252233 0.074548358 2290 forkhead box G1 "GO:0000122,GO:0000785,GO:0000981,GO:0002052,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007346,GO:0007420,GO:0007568,GO:0009953,GO:0016199,GO:0021852,GO:0042472,GO:0045665,GO:0045666,GO:0045787,GO:0045892,GO:0048664,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|positive regulation of neuroblast proliferation|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|regulation of mitotic cell cycle|brain development|aging|dorsal/ventral pattern formation|axon midline choice point recognition|pyramidal neuron migration|inner ear morphogenesis|negative regulation of neuron differentiation|positive regulation of neuron differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|neuron fate determination|sequence-specific double-stranded DNA binding" hsa04068 FoxO signaling pathway Fork_head FOXH1 5.508028946 6.08973581 4.926322083 0.808954975 -0.305868687 0.976518791 1 0.152912065 0.129027426 8928 forkhead box H1 "GO:0000122,GO:0000785,GO:0000976,GO:0000981,GO:0000987,GO:0001228,GO:0001947,GO:0003139,GO:0003151,GO:0003215,GO:0003222,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0007179,GO:0019904,GO:0032444,GO:0033147,GO:0035054,GO:0035909,GO:0043425,GO:0043433,GO:0043565,GO:0045893,GO:0045944,GO:0046332,GO:0048318,GO:0050681,GO:0060766,GO:0070410,GO:0070412,GO:0071345,GO:1900164" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|heart looping|secondary heart field specification|outflow tract morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|transforming growth factor beta receptor signaling pathway|protein domain specific binding|activin responsive factor complex|negative regulation of intracellular estrogen receptor signaling pathway|embryonic heart tube anterior/posterior pattern specification|aorta morphogenesis|bHLH transcription factor binding|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|axial mesoderm development|androgen receptor binding|negative regulation of androgen receptor signaling pathway|co-SMAD binding|R-SMAD binding|cellular response to cytokine stimulus|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" Fork_head FOXJ2 1065.410311 966.2380819 1164.58254 1.205274934 0.269362276 0.440185453 1 8.249587014 10.37132544 55810 forkhead box J2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0016525,GO:0042802,GO:0045944,GO:0110059,GO:1904707,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|negative regulation of angiogenesis|identical protein binding|positive regulation of transcription by RNA polymerase II|negative regulation of blood vessel endothelial cell differentiation|positive regulation of vascular associated smooth muscle cell proliferation|sequence-specific double-stranded DNA binding" FOXJ3 1784.772847 1883.758277 1685.787417 0.894906442 -0.160191232 0.623068334 1 15.57389997 14.53754074 22887 forkhead box J3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0043565,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" FOXK1 2154.510022 2137.497269 2171.522774 1.015918385 0.022784506 0.944875618 1 9.670957304 10.24812032 221937 forkhead box K1 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001678,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007517,GO:0010507,GO:0010906,GO:0016032,GO:0016579,GO:0030154,GO:0042594,GO:0045892,GO:0045893,GO:0061621,GO:0071889,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cellular glucose homeostasis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|muscle organ development|negative regulation of autophagy|regulation of glucose metabolic process|viral process|protein deubiquitination|cell differentiation|response to starvation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|canonical glycolysis|14-3-3 protein binding|sequence-specific double-stranded DNA binding" Fork_head FOXK2 1887.228222 1849.249774 1925.20667 1.041074438 0.058073227 0.859025137 1 17.86343264 19.39825346 3607 forkhead box K2 "GO:0000122,GO:0000287,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001678,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006355,GO:0006357,GO:0010507,GO:0010906,GO:0016579,GO:0042594,GO:0043231,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0061621" "negative regulation of transcription by RNA polymerase II|magnesium ion binding|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cellular glucose homeostasis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|negative regulation of autophagy|regulation of glucose metabolic process|protein deubiquitination|response to starvation|intracellular membrane-bounded organelle|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|canonical glycolysis" FOXL1 186.513128 188.7818101 184.2444459 0.975965035 -0.035098632 0.959768474 1 1.93937783 1.974297589 2300 forkhead box L1 "GO:0000785,GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005634,GO:0006357,GO:0007275,GO:0007495,GO:0007507,GO:0008301,GO:0009653,GO:0030111,GO:0030154,GO:0030166,GO:0043565,GO:0061146" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|visceral mesoderm-endoderm interaction involved in midgut development|heart development|DNA binding, bending|anatomical structure morphogenesis|regulation of Wnt signaling pathway|cell differentiation|proteoglycan biosynthetic process|sequence-specific DNA binding|Peyer's patch morphogenesis" FOXL2 123.1944246 103.5255088 142.8633404 1.379982017 0.464649467 0.465731666 1 1.799314277 2.589979834 668 forkhead box L2 "GO:0000785,GO:0000978,GO:0000981,GO:0001541,GO:0002074,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006309,GO:0006357,GO:0009653,GO:0030154,GO:0031624,GO:0043028,GO:0043065,GO:0043280,GO:0045892,GO:0045893,GO:0090543,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|ovarian follicle development|extraocular skeletal muscle development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|apoptotic DNA fragmentation|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|cell differentiation|ubiquitin conjugating enzyme binding|cysteine-type endopeptidase regulator activity involved in apoptotic process|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|Flemming body|sequence-specific double-stranded DNA binding" FOXL2NB 92.25039172 76.12169763 108.3790858 1.423760757 0.509706742 0.468048055 1 0.804024076 1.194048594 401089 FOXL2 neighbor GO:0001650 fibrillar center FOXM1 4274.69142 3645.721838 4903.661001 1.345045294 0.427654756 0.180779461 1 49.75557795 69.80629918 2305 forkhead box M1 "GO:0000086,GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006357,GO:0006978,GO:0008284,GO:0019901,GO:0032873,GO:0042127,GO:0045892,GO:0045893,GO:0045944,GO:0046578,GO:0051726,GO:0071156,GO:0090344,GO:2000377,GO:2000781" "G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|DNA repair|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|positive regulation of cell population proliferation|protein kinase binding|negative regulation of stress-activated MAPK cascade|regulation of cell population proliferation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of Ras protein signal transduction|regulation of cell cycle|regulation of cell cycle arrest|negative regulation of cell aging|regulation of reactive oxygen species metabolic process|positive regulation of double-strand break repair" hsa04218 Cellular senescence Fork_head FOXN2 392.8948479 388.7281359 397.0615599 1.021437666 0.030601165 0.950257475 1 3.307746763 3.52419598 3344 forkhead box N2 "GO:0000785,GO:0000981,GO:0000987,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0035914,GO:0043231,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|skeletal muscle cell differentiation|intracellular membrane-bounded organelle|sequence-specific double-stranded DNA binding" FOXN3 2008.537233 1823.875875 2193.198591 1.202493339 0.266028903 0.409118634 1 11.23074515 14.08663239 1112 forkhead box N3 "GO:0000785,GO:0000981,GO:0000987,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007095,GO:0008022,GO:0045892,GO:0097094" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|mitotic G2 DNA damage checkpoint|protein C-terminus binding|negative regulation of transcription, DNA-templated|craniofacial suture morphogenesis" FOXO1 611.0294712 718.5888256 503.4701169 0.700637275 -0.51326035 0.187547443 1 3.424671966 2.502811532 2308 forkhead box O1 "GO:0000785,GO:0000978,GO:0000981,GO:0001223,GO:0001228,GO:0001659,GO:0001678,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006357,GO:0006473,GO:0006914,GO:0006915,GO:0006974,GO:0008013,GO:0008286,GO:0009267,GO:0010508,GO:0019221,GO:0031018,GO:0031625,GO:0032869,GO:0032873,GO:0034599,GO:0043065,GO:0043066,GO:0043565,GO:0045444,GO:0045599,GO:0045732,GO:0045892,GO:0045893,GO:0045944,GO:0051721,GO:0070166,GO:0070301,GO:0070417,GO:0070542,GO:0071455,GO:0071549,GO:0071732,GO:0097009,GO:1902617,GO:1903243" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|temperature homeostasis|cellular glucose homeostasis|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|protein acetylation|autophagy|apoptotic process|cellular response to DNA damage stimulus|beta-catenin binding|insulin receptor signaling pathway|cellular response to starvation|positive regulation of autophagy|cytokine-mediated signaling pathway|endocrine pancreas development|ubiquitin protein ligase binding|cellular response to insulin stimulus|negative regulation of stress-activated MAPK cascade|cellular response to oxidative stress|positive regulation of apoptotic process|negative regulation of apoptotic process|sequence-specific DNA binding|fat cell differentiation|negative regulation of fat cell differentiation|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein phosphatase 2A binding|enamel mineralization|cellular response to hydrogen peroxide|cellular response to cold|response to fatty acid|cellular response to hyperoxia|cellular response to dexamethasone stimulus|cellular response to nitric oxide|energy homeostasis|response to fluoride|negative regulation of cardiac muscle hypertrophy in response to stress" "hsa04068,hsa04152,hsa04211,hsa04213,hsa04218,hsa04910,hsa04919,hsa04922,hsa04931,hsa04933,hsa05131,hsa05165,hsa05200,hsa05202,hsa05215" FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Insulin signaling pathway|Thyroid hormone signaling pathway|Glucagon signaling pathway|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Shigellosis|Human papillomavirus infection|Pathways in cancer|Transcriptional misregulation in cancer|Prostate cancer Fork_head FOXO3 778.5229382 920.5650633 636.4808131 0.691402312 -0.532402667 0.149718664 1 3.196446791 2.305229861 2309 forkhead box O3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005759,GO:0005829,GO:0006357,GO:0006390,GO:0006417,GO:0006915,GO:0008013,GO:0010508,GO:0014737,GO:0019221,GO:0019901,GO:0030336,GO:0031490,GO:0032991,GO:0033209,GO:0034246,GO:0034599,GO:0042149,GO:0042594,GO:0043065,GO:0043525,GO:0043565,GO:0045648,GO:0045893,GO:0045944,GO:0070542,GO:1902895,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial matrix|cytosol|regulation of transcription by RNA polymerase II|mitochondrial transcription|regulation of translation|apoptotic process|beta-catenin binding|positive regulation of autophagy|positive regulation of muscle atrophy|cytokine-mediated signaling pathway|protein kinase binding|negative regulation of cell migration|chromatin DNA binding|protein-containing complex|tumor necrosis factor-mediated signaling pathway|mitochondrial transcription factor activity|cellular response to oxidative stress|cellular response to glucose starvation|response to starvation|positive regulation of apoptotic process|positive regulation of neuron apoptotic process|sequence-specific DNA binding|positive regulation of erythrocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|response to fatty acid|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa01521,hsa04062,hsa04068,hsa04137,hsa04151,hsa04152,hsa04211,hsa04213,hsa04218,hsa04722,hsa04917,hsa05131,hsa05213,hsa05223" EGFR tyrosine kinase inhibitor resistance|Chemokine signaling pathway|FoxO signaling pathway|Mitophagy - animal|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Neurotrophin signaling pathway|Prolactin signaling pathway|Shigellosis|Endometrial cancer|Non-small cell lung cancer Fork_head FOXO3B 331.0067822 333.9205136 328.0930507 0.982548353 -0.025399688 0.96300074 1 2.844247564 2.914991257 2310 forkhead box O3B "GO:0003700,GO:0005829,GO:0006355,GO:0043565" "DNA-binding transcription factor activity|cytosol|regulation of transcription, DNA-templated|sequence-specific DNA binding" FOXO4 274.3028599 229.3800489 319.225671 1.391688913 0.476836759 0.327809691 1 3.112885924 4.518781094 4303 forkhead box O4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0007050,GO:0007095,GO:0007517,GO:0007568,GO:0008013,GO:0008134,GO:0008285,GO:0008286,GO:0014911,GO:0016525,GO:0016579,GO:0016607,GO:0019899,GO:0031667,GO:0042802,GO:0043565,GO:0045944,GO:0048863,GO:0051151,GO:0070317,GO:0071158,GO:1990785,GO:1990837,GO:1990841" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle arrest|mitotic G2 DNA damage checkpoint|muscle organ development|aging|beta-catenin binding|transcription factor binding|negative regulation of cell population proliferation|insulin receptor signaling pathway|positive regulation of smooth muscle cell migration|negative regulation of angiogenesis|protein deubiquitination|nuclear speck|enzyme binding|response to nutrient levels|identical protein binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|stem cell differentiation|negative regulation of smooth muscle cell differentiation|negative regulation of G0 to G1 transition|positive regulation of cell cycle arrest|response to water-immersion restraint stress|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" "hsa04014,hsa04068,hsa05131" Ras signaling pathway|FoxO signaling pathway|Shigellosis Fork_head FOXO6 22.37629024 14.20938356 30.54319691 2.149508935 1.104007107 0.311132957 1 0.249447192 0.559285815 100132074 forkhead box O6 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0007613,GO:0060999" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|memory|positive regulation of dendritic spine development" "hsa04068,hsa05131" FoxO signaling pathway|Shigellosis FOXP1 638.5183977 644.4970399 632.5397554 0.981447107 -0.027017576 0.948421986 1 2.427599392 2.48519144 27086 forkhead box P1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001046,GO:0001227,GO:0002903,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006974,GO:0010468,GO:0010595,GO:0010629,GO:0030316,GO:0032496,GO:0032625,GO:0032651,GO:0032655,GO:0032680,GO:0035019,GO:0036035,GO:0042116,GO:0042117,GO:0042118,GO:0042802,GO:0043621,GO:0045655,GO:0045892,GO:0046872,GO:0048661,GO:0050681,GO:0050727,GO:0050861,GO:0060766,GO:0061470,GO:1900424,GO:1901256,GO:1901509,GO:1990837,GO:2000341" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|core promoter sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|negative regulation of B cell apoptotic process|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|regulation of gene expression|positive regulation of endothelial cell migration|negative regulation of gene expression|osteoclast differentiation|response to lipopolysaccharide|interleukin-21 production|regulation of interleukin-1 beta production|regulation of interleukin-12 production|regulation of tumor necrosis factor production|somatic stem cell population maintenance|osteoclast development|macrophage activation|monocyte activation|endothelial cell activation|identical protein binding|protein self-association|regulation of monocyte differentiation|negative regulation of transcription, DNA-templated|metal ion binding|positive regulation of smooth muscle cell proliferation|androgen receptor binding|regulation of inflammatory response|positive regulation of B cell receptor signaling pathway|negative regulation of androgen receptor signaling pathway|T follicular helper cell differentiation|regulation of defense response to bacterium|regulation of macrophage colony-stimulating factor production|regulation of endothelial tube morphogenesis|sequence-specific double-stranded DNA binding|regulation of chemokine (C-X-C motif) ligand 2 production" hsa05206 MicroRNAs in cancer Fork_head FOXP2 76.3970864 70.03196182 82.76221099 1.181777703 0.240958685 0.757627664 1 0.456306678 0.562481893 93986 forkhead box P2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0021757,GO:0021758,GO:0021987,GO:0033574,GO:0042802,GO:0042803,GO:0043565,GO:0045892,GO:0046872,GO:0050681,GO:0098582" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|caudate nucleus development|putamen development|cerebral cortex development|response to testosterone|identical protein binding|protein homodimerization activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|androgen receptor binding|innate vocalization behavior" Fork_head FOXP4 530.5888906 439.4759343 621.7018468 1.414643666 0.500438699 0.21411843 1 3.783427791 5.582753323 116113 forkhead box P4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" FOXQ1 36.73413155 52.77771036 20.69055275 0.392032027 -1.350956577 0.149756623 1 1.004511402 0.410763975 94234 forkhead box Q1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0009653,GO:0030154,GO:0031069,GO:0043524,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|cell differentiation|hair follicle morphogenesis|negative regulation of neuron apoptotic process|sequence-specific double-stranded DNA binding" FOXRED1 1154.092027 1236.216369 1071.967685 0.867135974 -0.205669858 0.550847963 1 16.51978839 14.94196151 55572 FAD dependent oxidoreductase domain containing 1 "GO:0005737,GO:0005739,GO:0005743,GO:0005747,GO:0016021,GO:0016491,GO:0032981,GO:0055114" cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|integral component of membrane|oxidoreductase activity|mitochondrial respiratory chain complex I assembly|oxidation-reduction process FOXRED2 1207.276017 1302.188507 1112.363526 0.854226189 -0.227309966 0.506512837 1 13.18234141 11.74576661 80020 FAD dependent oxidoreductase domain containing 2 "GO:0005515,GO:0005788,GO:0016491,GO:0030433,GO:0050660,GO:0055114" protein binding|endoplasmic reticulum lumen|oxidoreductase activity|ubiquitin-dependent ERAD pathway|flavin adenine dinucleotide binding|oxidation-reduction process FPGS 1308.648888 1362.07091 1255.226867 0.92155765 -0.117853675 0.728455351 1 23.81224939 22.88963464 2356 folylpolyglutamate synthase "GO:0001889,GO:0004326,GO:0005524,GO:0005737,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006139,GO:0006536,GO:0006730,GO:0006760,GO:0007420,GO:0009396,GO:0031100,GO:0046655,GO:0046872,GO:0046901" liver development|tetrahydrofolylpolyglutamate synthase activity|ATP binding|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|nucleobase-containing compound metabolic process|glutamate metabolic process|one-carbon metabolic process|folic acid-containing compound metabolic process|brain development|folic acid-containing compound biosynthetic process|animal organ regeneration|folic acid metabolic process|metal ion binding|tetrahydrofolylpolyglutamate biosynthetic process "hsa00790,hsa01523" Folate biosynthesis|Antifolate resistance FPGT 83.02127015 118.7498483 47.29269199 0.398254757 -1.3282365 0.067738421 1 1.526074827 0.633946678 8790 fucose-1-phosphate guanylyltransferase "GO:0003824,GO:0005525,GO:0005737,GO:0005829,GO:0006004,GO:0047341" catalytic activity|GTP binding|cytoplasm|cytosol|fucose metabolic process|fucose-1-phosphate guanylyltransferase activity "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism FRA10AC1 592.2164133 577.509946 606.9228806 1.050930611 0.071667417 0.858853092 1 7.818455341 8.570594184 118924 FRA10A associated CGG repeat 1 "GO:0005515,GO:0005634,GO:0016311,GO:0016791" protein binding|nucleus|dephosphorylation|phosphatase activity FRAS1 885.8383253 1150.960068 620.7165824 0.539303317 -0.890831188 0.01385127 0.521881214 3.471418956 1.95279229 80144 Fraser extracellular matrix complex subunit 1 "GO:0002009,GO:0003338,GO:0005201,GO:0005604,GO:0005886,GO:0007154,GO:0015031,GO:0016021,GO:0030326,GO:0043588,GO:0046872,GO:0060021,GO:0062023" morphogenesis of an epithelium|metanephros morphogenesis|extracellular matrix structural constituent|basement membrane|plasma membrane|cell communication|protein transport|integral component of membrane|embryonic limb morphogenesis|skin development|metal ion binding|roof of mouth development|collagen-containing extracellular matrix hsa04512 ECM-receptor interaction FRAT1 194.350706 185.7369422 202.9644698 1.092752295 0.127966408 0.821959825 1 3.556491827 4.05377343 10023 FRAT regulator of WNT signaling pathway 1 "GO:0005515,GO:0005737,GO:0005829,GO:0043231,GO:0060070,GO:0090263,GO:1904886" protein binding|cytoplasm|cytosol|intracellular membrane-bounded organelle|canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|beta-catenin destruction complex disassembly "hsa04310,hsa05010,hsa05022,hsa05200,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer FRAT2 378.7124343 395.8328277 361.5920409 0.913496849 -0.130528342 0.771429467 1 8.977848772 8.554512575 23401 FRAT regulator of WNT signaling pathway 2 "GO:0003674,GO:0005575,GO:0005737,GO:0005829,GO:1904886" molecular_function|cellular_component|cytoplasm|cytosol|beta-catenin destruction complex disassembly "hsa04310,hsa05010,hsa05022,hsa05200,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer FREM2 7.986035764 7.104691779 8.867379749 1.248101962 0.319735798 0.916631795 1 0.022052312 0.028709136 341640 FRAS1 related extracellular matrix 2 "GO:0001654,GO:0001822,GO:0002009,GO:0005515,GO:0005604,GO:0005886,GO:0007154,GO:0007155,GO:0007507,GO:0016021,GO:0042733,GO:0046872,GO:0048839,GO:0070062" eye development|kidney development|morphogenesis of an epithelium|protein binding|basement membrane|plasma membrane|cell communication|cell adhesion|heart development|integral component of membrane|embryonic digit morphogenesis|metal ion binding|inner ear development|extracellular exosome hsa04512 ECM-receptor interaction FRG1 402.3587803 395.8328277 408.8847329 1.032973276 0.046802931 0.919723621 1 20.25003667 21.81879842 2483 FSHD region gene 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005730,GO:0006364,GO:0007517,GO:0015030,GO:0030018,GO:0051015,GO:0055120,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleolus|rRNA processing|muscle organ development|Cajal body|Z disc|actin filament binding|striated muscle dense body|catalytic step 2 spliceosome" FRK 22.45051911 19.2841634 25.61687483 1.328389223 0.409677923 0.73109464 1 0.069573646 0.096401999 2444 fyn related Src family tyrosine kinase "GO:0000122,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005576,GO:0005622,GO:0005634,GO:0005654,GO:0005829,GO:0006468,GO:0007169,GO:0008285,GO:0030154,GO:0031234,GO:0035578,GO:0035580,GO:0038083,GO:0042127,GO:0043312,GO:0045087,GO:0070062" negative regulation of transcription by RNA polymerase II|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|extracellular region|intracellular anatomical structure|nucleus|nucleoplasm|cytosol|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|negative regulation of cell population proliferation|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|azurophil granule lumen|specific granule lumen|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|neutrophil degranulation|innate immune response|extracellular exosome FRMD3 251.2354992 268.9633316 233.5076667 0.868176585 -0.203939582 0.688348143 1 1.197331801 1.084272682 257019 FERM domain containing 3 "GO:0005515,GO:0005856,GO:0008092,GO:0016021,GO:0031032" protein binding|cytoskeleton|cytoskeletal protein binding|integral component of membrane|actomyosin structure organization FRMD4A 2734.117674 2829.69724 2638.538108 0.932445376 -0.100908882 0.752067698 1 7.958803944 7.74082298 55691 FERM domain containing 4A "GO:0005737,GO:0005856,GO:0005912,GO:0005923,GO:0030674,GO:0050709,GO:0050714,GO:0090162" cytoplasm|cytoskeleton|adherens junction|bicellular tight junction|protein-macromolecule adaptor activity|negative regulation of protein secretion|positive regulation of protein secretion|establishment of epithelial cell polarity FRMD5 113.1609095 124.8395841 101.4822349 0.812901097 -0.298848259 0.653125686 1 1.149579005 0.974748248 84978 FERM domain containing 5 "GO:0005178,GO:0005515,GO:0005856,GO:0005912,GO:0008092,GO:0016021,GO:0019901,GO:0030334,GO:0031032,GO:0045785,GO:2000146" integrin binding|protein binding|cytoskeleton|adherens junction|cytoskeletal protein binding|integral component of membrane|protein kinase binding|regulation of cell migration|actomyosin structure organization|positive regulation of cell adhesion|negative regulation of cell motility FRMD6 2013.053317 1728.470014 2297.636619 1.329289256 0.410655072 0.202566374 1 13.76862355 19.09088011 122786 FERM domain containing 6 "GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0031032" protein binding|cytoplasm|cytoskeleton|plasma membrane|actomyosin structure organization "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species FRMD8 994.5400588 1038.299956 950.780162 0.915708565 -0.127039579 0.720464331 1 14.27034731 13.63037326 83786 FERM domain containing 8 "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0032760,GO:0034451" protein binding|nucleoplasm|cytosol|plasma membrane|positive regulation of tumor necrosis factor production|centriolar satellite FRMPD1 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.019532846 0.013185475 22844 FERM and PDZ domain containing 1 "GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0008277,GO:0032991,GO:0090150" protein binding|cytosol|cytoskeleton|plasma membrane|cell cortex|regulation of G protein-coupled receptor signaling pathway|protein-containing complex|establishment of protein localization to membrane FRMPD3 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.006211206 0.025156918 84443 FERM and PDZ domain containing 3 "GO:0005856,GO:0005886,GO:0030667,GO:0043312,GO:0070821" cytoskeleton|plasma membrane|secretory granule membrane|neutrophil degranulation|tertiary granule membrane FRMPD4 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.015748756 0.010631059 9758 FERM and PDZ domain containing 4 "GO:0005515,GO:0005546,GO:0005856,GO:0032991,GO:0043197,GO:0051835" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoskeleton|protein-containing complex|dendritic spine|positive regulation of synapse structural plasticity" FRRS1 57.36257959 82.21143344 32.51372575 0.395489099 -1.338290165 0.102211159 1 0.557392112 0.229938273 391059 ferric chelate reductase 1 "GO:0000293,GO:0016021,GO:0046872,GO:0055114" ferric-chelate reductase activity|integral component of membrane|metal ion binding|oxidation-reduction process FRS2 550.2887357 506.4630282 594.1144432 1.173065772 0.230283905 0.565592198 1 3.514257526 4.30003387 10818 fibroblast growth factor receptor substrate 2 "GO:0000165,GO:0000186,GO:0000187,GO:0001702,GO:0001759,GO:0003281,GO:0005068,GO:0005104,GO:0005168,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0005912,GO:0007185,GO:0007186,GO:0007405,GO:0007411,GO:0008543,GO:0008595,GO:0012505,GO:0016020,GO:0019211,GO:0030900,GO:0042981,GO:0046619,GO:0048011,GO:0050678,GO:0051897,GO:0060527,GO:0070307,GO:0070372,GO:2000726" "MAPK cascade|activation of MAPKK activity|activation of MAPK activity|gastrulation with mouth forming second|organ induction|ventricular septum development|transmembrane receptor protein tyrosine kinase adaptor activity|fibroblast growth factor receptor binding|neurotrophin TRKA receptor binding|protein binding|cytosol|plasma membrane|integral component of plasma membrane|adherens junction|transmembrane receptor protein tyrosine phosphatase signaling pathway|G protein-coupled receptor signaling pathway|neuroblast proliferation|axon guidance|fibroblast growth factor receptor signaling pathway|anterior/posterior axis specification, embryo|endomembrane system|membrane|phosphatase activator activity|forebrain development|regulation of apoptotic process|optic placode formation involved in camera-type eye formation|neurotrophin TRK receptor signaling pathway|regulation of epithelial cell proliferation|positive regulation of protein kinase B signaling|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|lens fiber cell development|regulation of ERK1 and ERK2 cascade|negative regulation of cardiac muscle cell differentiation" "hsa04714,hsa04722,hsa05205" Thermogenesis|Neurotrophin signaling pathway|Proteoglycans in cancer FRS3 138.6887097 118.7498483 158.6275711 1.335812831 0.417717877 0.495495741 1 1.553269858 2.164255128 10817 fibroblast growth factor receptor substrate 3 "GO:0000165,GO:0005104,GO:0005515,GO:0005886,GO:0007165,GO:0008543,GO:0042802" MAPK cascade|fibroblast growth factor receptor binding|protein binding|plasma membrane|signal transduction|fibroblast growth factor receptor signaling pathway|identical protein binding FRY 141.4366621 104.5404647 178.3328594 1.705873987 0.770511079 0.20295804 1 0.31637919 0.562951248 10129 FRY microtubule binding protein "GO:0000902,GO:0000922,GO:0005815,GO:0005938,GO:0030427,GO:0031175" cell morphogenesis|spindle pole|microtubule organizing center|cell cortex|site of polarized growth|neuron projection development FRYL 1821.057646 1771.098165 1871.017127 1.056416389 0.079178588 0.808619095 1 6.669135613 7.348870735 285527 FRY like transcription coactivator "GO:0000902,GO:0005515,GO:0005938,GO:0030427,GO:0031175" cell morphogenesis|protein binding|cell cortex|site of polarized growth|neuron projection development FRZB 38.9449144 35.52345889 42.36636991 1.192630764 0.254147457 0.803550293 1 0.682266922 0.848743094 2487 frizzled related protein "GO:0001501,GO:0005515,GO:0005615,GO:0005737,GO:0008285,GO:0010721,GO:0014033,GO:0016020,GO:0017147,GO:0030178,GO:0030308,GO:0035567,GO:0043065,GO:0045600,GO:0060029,GO:0060070,GO:0061037,GO:0061053,GO:0070367,GO:0090090,GO:0090103" skeletal system development|protein binding|extracellular space|cytoplasm|negative regulation of cell population proliferation|negative regulation of cell development|neural crest cell differentiation|membrane|Wnt-protein binding|negative regulation of Wnt signaling pathway|negative regulation of cell growth|non-canonical Wnt signaling pathway|positive regulation of apoptotic process|positive regulation of fat cell differentiation|convergent extension involved in organogenesis|canonical Wnt signaling pathway|negative regulation of cartilage development|somite development|negative regulation of hepatocyte differentiation|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis FSCN1 7243.145409 8586.527492 5899.763326 0.687095375 -0.541417723 0.099809601 1 156.2059361 111.9516474 6624 fascin actin-bundling protein 1 "GO:0001725,GO:0001726,GO:0002102,GO:0003723,GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005902,GO:0005911,GO:0005938,GO:0007043,GO:0007163,GO:0008144,GO:0010592,GO:0015629,GO:0016477,GO:0019221,GO:0030027,GO:0030035,GO:0030036,GO:0030046,GO:0030175,GO:0030426,GO:0030674,GO:0031253,GO:0032534,GO:0032956,GO:0035089,GO:0044393,GO:0045296,GO:0048870,GO:0051015,GO:0051017,GO:0051491,GO:0070062,GO:0071437,GO:0071803,GO:0090091" stress fiber|ruffle|podosome|RNA binding|actin binding|protein binding|cytoplasm|cytosol|cytoskeleton|microvillus|cell-cell junction|cell cortex|cell-cell junction assembly|establishment or maintenance of cell polarity|drug binding|positive regulation of lamellipodium assembly|actin cytoskeleton|cell migration|cytokine-mediated signaling pathway|lamellipodium|microspike assembly|actin cytoskeleton organization|parallel actin filament bundle assembly|filopodium|growth cone|protein-macromolecule adaptor activity|cell projection membrane|regulation of microvillus assembly|regulation of actin cytoskeleton organization|establishment of apical/basal cell polarity|microspike|cadherin binding|cell motility|actin filament binding|actin filament bundle assembly|positive regulation of filopodium assembly|extracellular exosome|invadopodium|positive regulation of podosome assembly|positive regulation of extracellular matrix disassembly hsa05206 MicroRNAs in cancer FSCN2 31.64450593 41.6131947 21.67581716 0.520888082 -0.940954667 0.337203364 1 0.361937405 0.19664994 25794 "fascin actin-bundling protein 2, retinal" "GO:0003779,GO:0005515,GO:0005737,GO:0007163,GO:0007601,GO:0009653,GO:0015629,GO:0016477,GO:0030036,GO:0030674,GO:0032420,GO:0042462,GO:0051015,GO:0051017" actin binding|protein binding|cytoplasm|establishment or maintenance of cell polarity|visual perception|anatomical structure morphogenesis|actin cytoskeleton|cell migration|actin cytoskeleton organization|protein-macromolecule adaptor activity|stereocilium|eye photoreceptor cell development|actin filament binding|actin filament bundle assembly FSCN3 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.048108507 0.073069252 29999 fascin actin-bundling protein 3 "GO:0001726,GO:0005737,GO:0005856,GO:0005902,GO:0007163,GO:0007286,GO:0015629,GO:0016477,GO:0030027,GO:0030175,GO:0030426,GO:0030674,GO:0031253,GO:0051015,GO:0051017" ruffle|cytoplasm|cytoskeleton|microvillus|establishment or maintenance of cell polarity|spermatid development|actin cytoskeleton|cell migration|lamellipodium|filopodium|growth cone|protein-macromolecule adaptor activity|cell projection membrane|actin filament binding|actin filament bundle assembly FSD1 761.6534392 743.9627248 779.3441535 1.047558066 0.067030215 0.859802941 1 21.62978615 23.63449138 79187 fibronectin type III and SPRY domain containing 1 "GO:0005634,GO:0005737,GO:0005813,GO:0005874,GO:0007049,GO:0008017,GO:0031122,GO:0032154,GO:0032465,GO:0042802,GO:0051301,GO:0051302,GO:0060236" nucleus|cytoplasm|centrosome|microtubule|cell cycle|microtubule binding|cytoplasmic microtubule organization|cleavage furrow|regulation of cytokinesis|identical protein binding|cell division|regulation of cell division|regulation of mitotic spindle organization FSD1L 207.7084371 223.290313 192.1265612 0.860433928 -0.216863681 0.689124698 1 1.18541579 1.06390822 83856 fibronectin type III and SPRY domain containing 1 like "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process FSIP1 8.538051076 11.16451565 5.911586499 0.529497802 -0.917303399 0.571398598 1 0.06574158 0.036309497 161835 fibrous sheath interacting protein 1 FSIP2 4.97085941 3.044867905 6.896850916 2.265073931 1.17955814 0.582594813 1 0.007531713 0.017794757 401024 fibrous sheath interacting protein 2 "GO:0003674,GO:0007288,GO:0030317,GO:0061512,GO:0097224,GO:0097225,GO:0097228,GO:0097229" molecular_function|sperm axoneme assembly|flagellated sperm motility|protein localization to cilium|sperm connecting piece|sperm midpiece|sperm principal piece|sperm end piece FST 392.3576783 385.683268 399.0320887 1.034610837 0.049088208 0.916249412 1 5.225654605 5.639409792 10468 follistatin "GO:0000122,GO:0001501,GO:0002244,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0007275,GO:0007276,GO:0007389,GO:0008585,GO:0030154,GO:0030509,GO:0030510,GO:0031069,GO:0032926,GO:0038102,GO:0042475,GO:0043395,GO:0043616,GO:0045596,GO:0048185,GO:0051798" negative regulation of transcription by RNA polymerase II|skeletal system development|hematopoietic progenitor cell differentiation|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|multicellular organism development|gamete generation|pattern specification process|female gonad development|cell differentiation|BMP signaling pathway|regulation of BMP signaling pathway|hair follicle morphogenesis|negative regulation of activin receptor signaling pathway|activin receptor antagonist activity|odontogenesis of dentin-containing tooth|heparan sulfate proteoglycan binding|keratinocyte proliferation|negative regulation of cell differentiation|activin binding|positive regulation of hair follicle development hsa04350 TGF-beta signaling pathway FSTL1 7368.835647 6267.353105 8470.318189 1.351498479 0.434559888 0.186621488 1 45.52772875 64.18114729 11167 follistatin like 1 "GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0007275,GO:0008201,GO:0030154,GO:0030509,GO:0030510,GO:0043066,GO:0043542,GO:0043687,GO:0044267,GO:0045446,GO:0061484,GO:0070062" calcium ion binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|multicellular organism development|heparin binding|cell differentiation|BMP signaling pathway|regulation of BMP signaling pathway|negative regulation of apoptotic process|endothelial cell migration|post-translational protein modification|cellular protein metabolic process|endothelial cell differentiation|hematopoietic stem cell homeostasis|extracellular exosome FSTL3 986.3164906 1014.955968 957.6770129 0.943565083 -0.083806062 0.814743478 1 20.55335436 20.22881772 10272 follistatin like 3 "GO:0001503,GO:0001822,GO:0001968,GO:0002244,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005788,GO:0005794,GO:0006357,GO:0007275,GO:0007283,GO:0008584,GO:0022409,GO:0030141,GO:0030154,GO:0030324,GO:0030325,GO:0030510,GO:0030514,GO:0032926,GO:0043687,GO:0044267,GO:0044306,GO:0045671,GO:0045944,GO:0048185,GO:0071248,GO:0090101" ossification|kidney development|fibronectin binding|hematopoietic progenitor cell differentiation|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|endoplasmic reticulum lumen|Golgi apparatus|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|male gonad development|positive regulation of cell-cell adhesion|secretory granule|cell differentiation|lung development|adrenal gland development|regulation of BMP signaling pathway|negative regulation of BMP signaling pathway|negative regulation of activin receptor signaling pathway|post-translational protein modification|cellular protein metabolic process|neuron projection terminus|negative regulation of osteoclast differentiation|positive regulation of transcription by RNA polymerase II|activin binding|cellular response to metal ion|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway FTCD 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.032377035 0 10841 formimidoyltransferase cyclodeaminase "GO:0000139,GO:0005515,GO:0005542,GO:0005737,GO:0005783,GO:0005793,GO:0005794,GO:0005814,GO:0005829,GO:0005886,GO:0006548,GO:0006760,GO:0007010,GO:0008017,GO:0019556,GO:0019557,GO:0030407,GO:0030409,GO:0030412,GO:0030868,GO:0035999,GO:0070062" Golgi membrane|protein binding|folic acid binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|centriole|cytosol|plasma membrane|histidine catabolic process|folic acid-containing compound metabolic process|cytoskeleton organization|microtubule binding|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate|formimidoyltransferase activity|glutamate formimidoyltransferase activity|formimidoyltetrahydrofolate cyclodeaminase activity|smooth endoplasmic reticulum membrane|tetrahydrofolate interconversion|extracellular exosome "hsa00340,hsa00670" Histidine metabolism|One carbon pool by folate FTCDNL1 24.59919726 31.46363502 17.7347595 0.563658951 -0.82710559 0.438078399 1 0.080056374 0.047068272 348751 formiminotransferase cyclodeaminase N-terminal like "GO:0005542,GO:0016740" folic acid binding|transferase activity FTH1 171910.5172 203196.2148 140624.8196 0.69206417 -0.531022281 0.334241293 1 8554.58973 6175.34863 2495 ferritin heavy chain 1 "GO:0004322,GO:0005506,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006826,GO:0006879,GO:0006880,GO:0006955,GO:0008043,GO:0008198,GO:0008199,GO:0008285,GO:0043312,GO:0044754,GO:0048147,GO:0055114,GO:0070062,GO:1904724,GO:1904813" ferroxidase activity|iron ion binding|protein binding|extracellular region|nucleus|cytoplasm|cytosol|iron ion transport|cellular iron ion homeostasis|intracellular sequestering of iron ion|immune response|intracellular ferritin complex|ferrous iron binding|ferric iron binding|negative regulation of cell population proliferation|neutrophil degranulation|autolysosome|negative regulation of fibroblast proliferation|oxidation-reduction process|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen "hsa04216,hsa04217,hsa04978" Ferroptosis|Necroptosis|Mineral absorption FTL 12983.49139 12978.24197 12988.7408 1.000808957 0.001166606 0.997556545 1 754.6523205 787.79646 2512 ferritin light chain "GO:0005506,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006826,GO:0006879,GO:0006880,GO:0008043,GO:0008198,GO:0008199,GO:0016020,GO:0035578,GO:0042802,GO:0043312,GO:0044754,GO:0055072,GO:0070062" iron ion binding|protein binding|extracellular region|cytoplasm|cytosol|iron ion transport|cellular iron ion homeostasis|intracellular sequestering of iron ion|intracellular ferritin complex|ferrous iron binding|ferric iron binding|membrane|azurophil granule lumen|identical protein binding|neutrophil degranulation|autolysosome|iron ion homeostasis|extracellular exosome "hsa04216,hsa04217,hsa04978" Ferroptosis|Necroptosis|Mineral absorption FTO 886.6875022 804.8600829 968.5149215 1.203333277 0.267036269 0.458995004 1 3.080895157 3.867040996 79068 FTO alpha-ketoglutarate dependent dioxygenase "GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006307,GO:0008198,GO:0010883,GO:0016607,GO:0016740,GO:0035515,GO:0035516,GO:0035552,GO:0035553,GO:0040014,GO:0042245,GO:0043231,GO:0043734,GO:0061157,GO:0070989,GO:0080111,GO:0090335,GO:1990931,GO:1990984" nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|DNA dealkylation involved in DNA repair|ferrous iron binding|regulation of lipid storage|nuclear speck|transferase activity|oxidative RNA demethylase activity|oxidative DNA demethylase activity|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|regulation of multicellular organism growth|RNA repair|intracellular membrane-bounded organelle|DNA-N1-methyladenine dioxygenase activity|mRNA destabilization|oxidative demethylation|DNA demethylation|regulation of brown fat cell differentiation|RNA N6-methyladenosine dioxygenase activity|tRNA demethylase activity FTSJ1 1669.139374 1690.916643 1647.362104 0.974242054 -0.037647835 0.910248904 1 39.22994173 39.86579831 24140 FtsJ RNA 2'-O-methyltransferase 1 "GO:0001510,GO:0002128,GO:0002181,GO:0005515,GO:0005737,GO:0005829,GO:0006400,GO:0008173,GO:0008175,GO:0009020,GO:0030488,GO:0052666" RNA methylation|tRNA nucleoside ribose methylation|cytoplasmic translation|protein binding|cytoplasm|cytosol|tRNA modification|RNA methyltransferase activity|tRNA methyltransferase activity|tRNA (guanosine-2'-O-)-methyltransferase activity|tRNA methylation|tRNA (cytosine-2'-O-)-methyltransferase activity FTSJ3 1362.329469 1563.032191 1161.626747 0.743187987 -0.428200914 0.202340094 1 22.19912127 17.20879235 117246 FtsJ RNA 2'-O-methyltransferase 3 "GO:0000453,GO:0000463,GO:0000466,GO:0001510,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0008173,GO:0008650,GO:0016435,GO:0030687,GO:0030688,GO:0031167,GO:0062105" "enzyme-directed rRNA 2'-O-methylation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA methylation|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|RNA methyltransferase activity|rRNA (uridine-2'-O-)-methyltransferase activity|rRNA (guanine) methyltransferase activity|preribosome, large subunit precursor|preribosome, small subunit precursor|rRNA methylation|RNA 2'-O-methyltransferase activity" FUBP1 2603.500115 2589.152675 2617.847555 1.01108273 0.015901048 0.961505254 1 19.23876893 20.28989972 8880 far upstream element binding protein 1 "GO:0003697,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0010468,GO:0010628" single-stranded DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of gene expression|positive regulation of gene expression FUBP3 2008.703012 2172.005772 1845.400252 0.849629534 -0.235094178 0.465787318 1 18.74968979 16.61650249 8939 far upstream element binding protein 3 "GO:0003697,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0006351,GO:0010468,GO:0010628,GO:0016020,GO:0045893,GO:0045944" "single-stranded DNA binding|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|transcription, DNA-templated|regulation of gene expression|positive regulation of gene expression|membrane|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II" FUCA1 934.1229627 1252.455665 615.7902603 0.491666314 -1.024248581 0.004369508 0.243721434 19.0088286 9.748588498 2517 alpha-L-fucosidase 1 "GO:0004560,GO:0005515,GO:0005576,GO:0005737,GO:0005764,GO:0006004,GO:0006027,GO:0016139,GO:0019377,GO:0035578,GO:0043202,GO:0043312,GO:0070062" alpha-L-fucosidase activity|protein binding|extracellular region|cytoplasm|lysosome|fucose metabolic process|glycosaminoglycan catabolic process|glycoside catabolic process|glycolipid catabolic process|azurophil granule lumen|lysosomal lumen|neutrophil degranulation|extracellular exosome "hsa00511,hsa04142" Other glycan degradation|Lysosome FUCA2 1787.311721 1686.856819 1887.766622 1.119103056 0.162342898 0.618349125 1 35.82110987 41.81432103 2519 alpha-L-fucosidase 2 "GO:0004560,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005788,GO:0006004,GO:0009617,GO:0016139,GO:0035578,GO:0043312,GO:0043687,GO:0044267,GO:0070062,GO:2000535" alpha-L-fucosidase activity|protein binding|extracellular region|extracellular space|lysosome|endoplasmic reticulum lumen|fucose metabolic process|response to bacterium|glycoside catabolic process|azurophil granule lumen|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|extracellular exosome|regulation of entry of bacterium into host cell "hsa00511,hsa04142" Other glycan degradation|Lysosome FUNDC1 417.4198163 415.1169911 419.7226414 1.011094825 0.015918306 0.976583644 1 19.9470694 21.03715061 139341 FUN14 domain containing 1 "GO:0000422,GO:0001666,GO:0005515,GO:0005741,GO:0010243,GO:0016236,GO:0031307" autophagy of mitochondrion|response to hypoxia|protein binding|mitochondrial outer membrane|response to organonitrogen compound|macroautophagy|integral component of mitochondrial outer membrane hsa04137 Mitophagy - animal FUNDC2 923.9318333 825.1592023 1022.704464 1.239402604 0.309644905 0.386618091 1 6.636716311 8.579887395 65991 FUN14 domain containing 2 "GO:0000422,GO:0005515,GO:0005634,GO:0005739,GO:0031307" autophagy of mitochondrion|protein binding|nucleus|mitochondrion|integral component of mitochondrial outer membrane FURIN 5098.42023 4895.132635 5301.707825 1.083057032 0.115109215 0.720511605 1 52.85039416 59.70565773 5045 "furin, paired basic amino acid cleaving enzyme" "GO:0000139,GO:0001825,GO:0002020,GO:0004175,GO:0004252,GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005796,GO:0005802,GO:0005886,GO:0006465,GO:0007179,GO:0008233,GO:0009966,GO:0009986,GO:0010008,GO:0010951,GO:0016020,GO:0016485,GO:0016486,GO:0019058,GO:0019082,GO:0022617,GO:0030140,GO:0030173,GO:0030198,GO:0030574,GO:0031638,GO:0032374,GO:0032455,GO:0032804,GO:0032902,GO:0032904,GO:0032911,GO:0032940,GO:0042176,GO:0042277,GO:0043043,GO:0044267,GO:0045121,GO:0046872,GO:0048406,GO:0051004,GO:0051044,GO:0052548,GO:0070062,GO:0070268,GO:0090472,GO:1901394" Golgi membrane|blastocyst formation|protease binding|endopeptidase activity|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum|Golgi lumen|trans-Golgi network|plasma membrane|signal peptide processing|transforming growth factor beta receptor signaling pathway|peptidase activity|regulation of signal transduction|cell surface|endosome membrane|negative regulation of endopeptidase activity|membrane|protein processing|peptide hormone processing|viral life cycle|viral protein processing|extracellular matrix disassembly|trans-Golgi network transport vesicle|integral component of Golgi membrane|extracellular matrix organization|collagen catabolic process|zymogen activation|regulation of cholesterol transport|nerve growth factor processing|negative regulation of low-density lipoprotein particle receptor catabolic process|nerve growth factor production|negative regulation of nerve growth factor production|negative regulation of transforming growth factor beta1 production|secretion by cell|regulation of protein catabolic process|peptide binding|peptide biosynthetic process|cellular protein metabolic process|membrane raft|metal ion binding|nerve growth factor binding|regulation of lipoprotein lipase activity|positive regulation of membrane protein ectodomain proteolysis|regulation of endopeptidase activity|extracellular exosome|cornification|dibasic protein processing|positive regulation of transforming growth factor beta1 activation FUS 5091.359338 5995.344905 4187.37377 0.698437511 -0.517797052 0.107742931 1 163.8656606 119.3799626 2521 FUS RNA binding protein "GO:0000398,GO:0003677,GO:0003682,GO:0003712,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0008380,GO:0042802,GO:0043484,GO:0045893,GO:0046872,GO:0048255,GO:0051260,GO:1905168" "mRNA splicing, via spliceosome|DNA binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|RNA splicing|identical protein binding|regulation of RNA splicing|positive regulation of transcription, DNA-templated|metal ion binding|mRNA stabilization|protein homooligomerization|positive regulation of double-strand break repair via homologous recombination" "hsa03013,hsa03015,hsa03040,hsa05014,hsa05022,hsa05202" RNA transport|mRNA surveillance pathway|Spliceosome|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Transcriptional misregulation in cancer FUT1 33.67713947 12.17947162 55.17480733 4.530147862 2.17955814 0.028295778 0.744700915 0.155103664 0.732909522 2523 fucosyltransferase 1 (H blood group) "GO:0001936,GO:0001954,GO:0005794,GO:0005887,GO:0005975,GO:0006486,GO:0008107,GO:0008417,GO:0010595,GO:0016020,GO:0021772,GO:0030155,GO:0031127,GO:0032580,GO:0036065,GO:0042355,GO:1903672,GO:1904906" "regulation of endothelial cell proliferation|positive regulation of cell-matrix adhesion|Golgi apparatus|integral component of plasma membrane|carbohydrate metabolic process|protein glycosylation|galactoside 2-alpha-L-fucosyltransferase activity|fucosyltransferase activity|positive regulation of endothelial cell migration|membrane|olfactory bulb development|regulation of cell adhesion|alpha-(1,2)-fucosyltransferase activity|Golgi cisterna membrane|fucosylation|L-fucose catabolic process|positive regulation of sprouting angiogenesis|positive regulation of endothelial cell-matrix adhesion via fibronectin" "hsa00601,hsa00603" Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series FUT10 195.1105622 204.0061496 186.2149747 0.912790987 -0.131643548 0.816332038 1 2.03589986 1.938401269 84750 fucosyltransferase 10 "GO:0005654,GO:0005783,GO:0005794,GO:0006457,GO:0006486,GO:0006605,GO:0007399,GO:0009566,GO:0016021,GO:0030097,GO:0032580,GO:0036065,GO:0042060,GO:0042355,GO:0046920" nucleoplasm|endoplasmic reticulum|Golgi apparatus|protein folding|protein glycosylation|protein targeting|nervous system development|fertilization|integral component of membrane|hemopoiesis|Golgi cisterna membrane|fucosylation|wound healing|L-fucose catabolic process|alpha-(1->3)-fucosyltransferase activity FUT11 1160.887433 1566.077059 755.6978075 0.482541905 -1.05127386 0.002428917 0.159813301 33.79475 17.00983897 170384 fucosyltransferase 11 "GO:0005515,GO:0006486,GO:0016021,GO:0032580,GO:0036065,GO:0046920" protein binding|protein glycosylation|integral component of membrane|Golgi cisterna membrane|fucosylation|alpha-(1->3)-fucosyltransferase activity FUT4 164.3446786 188.7818101 139.9075471 0.741107139 -0.432245973 0.454415669 1 1.600189573 1.236996192 2526 fucosyltransferase 4 "GO:0005794,GO:0005802,GO:0005975,GO:0006486,GO:0008417,GO:0009311,GO:0009986,GO:0016020,GO:0016021,GO:0017083,GO:0032580,GO:0036065,GO:0042355,GO:0046920,GO:0071944,GO:1903037,GO:1903238" Golgi apparatus|trans-Golgi network|carbohydrate metabolic process|protein glycosylation|fucosyltransferase activity|oligosaccharide metabolic process|cell surface|membrane|integral component of membrane|4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity|Golgi cisterna membrane|fucosylation|L-fucose catabolic process|alpha-(1->3)-fucosyltransferase activity|cell periphery|regulation of leukocyte cell-cell adhesion|positive regulation of leukocyte tethering or rolling "hsa00515,hsa00601" Mannose type O-glycan biosynthesis|Glycosphingolipid biosynthesis - lacto and neolacto series FUT8 1105.799225 1235.201414 976.3970368 0.790475971 -0.339206487 0.327771127 1 6.765285397 5.578156887 2530 fucosyltransferase 8 "GO:0000139,GO:0001701,GO:0005515,GO:0005794,GO:0006487,GO:0006491,GO:0007179,GO:0007229,GO:0007585,GO:0008424,GO:0009312,GO:0010468,GO:0016020,GO:0016021,GO:0016477,GO:0017124,GO:0018279,GO:0032580,GO:0033578,GO:0036071,GO:0042355,GO:0043112,GO:0046368,GO:0046921,GO:0070062,GO:1900407" Golgi membrane|in utero embryonic development|protein binding|Golgi apparatus|protein N-linked glycosylation|N-glycan processing|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|respiratory gaseous exchange by respiratory system|glycoprotein 6-alpha-L-fucosyltransferase activity|oligosaccharide biosynthetic process|regulation of gene expression|membrane|integral component of membrane|cell migration|SH3 domain binding|protein N-linked glycosylation via asparagine|Golgi cisterna membrane|protein glycosylation in Golgi|N-glycan fucosylation|L-fucose catabolic process|receptor metabolic process|GDP-L-fucose metabolic process|alpha-(1->6)-fucosyltransferase activity|extracellular exosome|regulation of cellular response to oxidative stress "hsa00510,hsa00513,hsa00533,hsa05202" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Transcriptional misregulation in cancer FUZ 317.1240057 327.8307778 306.4172335 0.934681105 -0.097453866 0.839782668 1 6.877991871 6.705652615 80199 fuzzy planar cell polarity protein "GO:0001736,GO:0001843,GO:0001942,GO:0005515,GO:0005737,GO:0005856,GO:0008285,GO:0008589,GO:0010172,GO:0015031,GO:0016192,GO:0030336,GO:0042995,GO:0045724,GO:0048704,GO:0060271,GO:0070062,GO:0090090,GO:0090301,GO:1905515,GO:2000314" establishment of planar polarity|neural tube closure|hair follicle development|protein binding|cytoplasm|cytoskeleton|negative regulation of cell population proliferation|regulation of smoothened signaling pathway|embryonic body morphogenesis|protein transport|vesicle-mediated transport|negative regulation of cell migration|cell projection|positive regulation of cilium assembly|embryonic skeletal system morphogenesis|cilium assembly|extracellular exosome|negative regulation of canonical Wnt signaling pathway|negative regulation of neural crest formation|non-motile cilium assembly|negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation FXN 246.6088142 255.768904 237.4487244 0.928372138 -0.107224869 0.838323069 1 1.856376138 1.797645307 2395 frataxin "GO:0004322,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0006119,GO:0006783,GO:0006811,GO:0006879,GO:0007005,GO:0007628,GO:0008198,GO:0008199,GO:0008284,GO:0009060,GO:0009792,GO:0010039,GO:0010722,GO:0016226,GO:0016540,GO:0018283,GO:0019230,GO:0030307,GO:0034986,GO:0040015,GO:0043066,GO:0043085,GO:0044281,GO:0046621,GO:0051349,GO:0051537,GO:0070301,GO:0090201,GO:1904231,GO:1904234,GO:1990221" "ferroxidase activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|oxidative phosphorylation|heme biosynthetic process|ion transport|cellular iron ion homeostasis|mitochondrion organization|adult walking behavior|ferrous iron binding|ferric iron binding|positive regulation of cell population proliferation|aerobic respiration|embryo development ending in birth or egg hatching|response to iron ion|regulation of ferrochelatase activity|iron-sulfur cluster assembly|protein autoprocessing|iron incorporation into metallo-sulfur cluster|proprioception|positive regulation of cell growth|iron chaperone activity|negative regulation of multicellular organism growth|negative regulation of apoptotic process|positive regulation of catalytic activity|small molecule metabolic process|negative regulation of organ growth|positive regulation of lyase activity|2 iron, 2 sulfur cluster binding|cellular response to hydrogen peroxide|negative regulation of release of cytochrome c from mitochondria|positive regulation of succinate dehydrogenase activity|positive regulation of aconitate hydratase activity|L-cysteine desulfurase complex" hsa00860 Porphyrin and chlorophyll metabolism FXR1 3809.827486 3624.407763 3995.247209 1.102317253 0.140539499 0.659286091 1 56.39430632 64.84220778 8087 FMR1 autosomal homolog 1 "GO:0000381,GO:0001934,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005844,GO:0006915,GO:0007517,GO:0014069,GO:0016020,GO:0017148,GO:0030154,GO:0030424,GO:0030426,GO:0033592,GO:0036464,GO:0042803,GO:0043025,GO:0043034,GO:0043197,GO:0043488,GO:0044326,GO:0045182,GO:0045727,GO:0046982,GO:0048471,GO:0051489,GO:0060538,GO:0098793,GO:0098978,GO:1902737,GO:2000637,GO:2001022" "regulation of alternative mRNA splicing, via spliceosome|positive regulation of protein phosphorylation|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleolus|cytoplasm|cytosol|polysome|apoptotic process|muscle organ development|postsynaptic density|membrane|negative regulation of translation|cell differentiation|axon|growth cone|RNA strand annealing activity|cytoplasmic ribonucleoprotein granule|protein homodimerization activity|neuronal cell body|costamere|dendritic spine|regulation of mRNA stability|dendritic spine neck|translation regulator activity|positive regulation of translation|protein heterodimerization activity|perinuclear region of cytoplasm|regulation of filopodium assembly|skeletal muscle organ development|presynapse|glutamatergic synapse|dendritic filopodium|positive regulation of gene silencing by miRNA|positive regulation of response to DNA damage stimulus" hsa03013 RNA transport FXR2 1517.423746 1321.472671 1713.37482 1.296564703 0.374694203 0.257860972 1 22.40640405 30.30276705 9513 FMR1 autosomal homolog 2 "GO:0000381,GO:0001934,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0014069,GO:0016020,GO:0017148,GO:0022625,GO:0030424,GO:0030426,GO:0036464,GO:0042802,GO:0042803,GO:0043025,GO:0043197,GO:0043488,GO:0044326,GO:0045182,GO:0045727,GO:0046982,GO:0051489,GO:0098793,GO:1902737,GO:2001022" "regulation of alternative mRNA splicing, via spliceosome|positive regulation of protein phosphorylation|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|polysome|postsynaptic density|membrane|negative regulation of translation|cytosolic large ribosomal subunit|axon|growth cone|cytoplasmic ribonucleoprotein granule|identical protein binding|protein homodimerization activity|neuronal cell body|dendritic spine|regulation of mRNA stability|dendritic spine neck|translation regulator activity|positive regulation of translation|protein heterodimerization activity|regulation of filopodium assembly|presynapse|dendritic filopodium|positive regulation of response to DNA damage stimulus" hsa03013 RNA transport FXYD1 7.523095107 9.134603715 5.911586499 0.64716398 -0.627796782 0.748279434 1 0.377046009 0.254521583 5348 FXYD domain containing ion transport regulator 1 "GO:0005254,GO:0005886,GO:0005887,GO:0005890,GO:0005901,GO:0006813,GO:0006814,GO:0006821,GO:0006936,GO:0008016,GO:0010734,GO:0014704,GO:0016324,GO:0017080,GO:0030315,GO:0034220,GO:0042383,GO:0044325,GO:0086036,GO:0099106,GO:1902476,GO:1903278,GO:1903779,GO:2000649" chloride channel activity|plasma membrane|integral component of plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|potassium ion transport|sodium ion transport|chloride transport|muscle contraction|regulation of heart contraction|negative regulation of protein glutathionylation|intercalated disc|apical plasma membrane|sodium channel regulator activity|T-tubule|ion transmembrane transport|sarcolemma|ion channel binding|regulation of cardiac muscle cell membrane potential|ion channel regulator activity|chloride transmembrane transport|positive regulation of sodium ion export across plasma membrane|regulation of cardiac conduction|regulation of sodium ion transmembrane transporter activity hsa04024 cAMP signaling pathway FXYD5 2527.383861 2369.922186 2684.845535 1.132883413 0.179999399 0.572903694 1 136.706376 161.5436601 53827 FXYD domain containing ion transport regulator 5 "GO:0003779,GO:0005515,GO:0006811,GO:0016021,GO:0017080,GO:0030033,GO:0045296,GO:0046588,GO:0099106,GO:2000649" actin binding|protein binding|ion transport|integral component of membrane|sodium channel regulator activity|microvillus assembly|cadherin binding|negative regulation of calcium-dependent cell-cell adhesion|ion channel regulator activity|regulation of sodium ion transmembrane transporter activity FXYD7 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.072604434 0.220549422 53822 FXYD domain containing ion transport regulator 7 "GO:0005515,GO:0005886,GO:0016021,GO:0017080,GO:0034220,GO:0099106,GO:1903779,GO:2000649" protein binding|plasma membrane|integral component of membrane|sodium channel regulator activity|ion transmembrane transport|ion channel regulator activity|regulation of cardiac conduction|regulation of sodium ion transmembrane transporter activity FYCO1 1366.327434 1230.126634 1502.528235 1.221441918 0.288585263 0.390105518 1 5.426966408 6.914262818 79443 FYVE and coiled-coil domain autophagy adaptor 1 "GO:0005515,GO:0005764,GO:0005770,GO:0005776,GO:0005794,GO:0016020,GO:0043231,GO:0046872,GO:0072383,GO:1901098" protein binding|lysosome|late endosome|autophagosome|Golgi apparatus|membrane|intracellular membrane-bounded organelle|metal ion binding|plus-end-directed vesicle transport along microtubule|positive regulation of autophagosome maturation hsa05132 Salmonella infection FYN 542.9816463 411.0571672 674.9061253 1.641878987 0.715347799 0.074530665 1 4.73580423 8.110559518 2534 "FYN proto-oncogene, Src family tyrosine kinase" "GO:0000165,GO:0000304,GO:0001764,GO:0002223,GO:0002250,GO:0003015,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005768,GO:0005829,GO:0005884,GO:0005886,GO:0006468,GO:0006816,GO:0007169,GO:0007411,GO:0007596,GO:0007612,GO:0007631,GO:0008360,GO:0010629,GO:0010730,GO:0010976,GO:0014068,GO:0014069,GO:0018108,GO:0019221,GO:0019899,GO:0030154,GO:0030168,GO:0030425,GO:0030900,GO:0031234,GO:0031295,GO:0031397,GO:0031802,GO:0035556,GO:0036120,GO:0038083,GO:0038096,GO:0042127,GO:0042177,GO:0042493,GO:0042531,GO:0042542,GO:0042608,GO:0042609,GO:0042610,GO:0042802,GO:0043014,GO:0043123,GO:0043524,GO:0043548,GO:0044297,GO:0044325,GO:0045087,GO:0045121,GO:0045471,GO:0046872,GO:0046875,GO:0048010,GO:0048013,GO:0048156,GO:0048471,GO:0048813,GO:0050321,GO:0050690,GO:0050730,GO:0050798,GO:0050804,GO:0050852,GO:0050900,GO:0050966,GO:0051428,GO:0051897,GO:0070851,GO:0071375,GO:0071560,GO:0090314,GO:0097038,GO:0097062,GO:0097386,GO:0097718,GO:0098685,GO:0098978,GO:0099092,GO:1900182,GO:1900449,GO:1901216,GO:1902951,GO:1903202,GO:1903997,GO:1904645,GO:1904646,GO:1905232,GO:1905430,GO:1905477,GO:1905664,GO:2001056,GO:2001240" "MAPK cascade|response to singlet oxygen|neuron migration|stimulatory C-type lectin receptor signaling pathway|adaptive immune response|heart process|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|nucleus|mitochondrion|endosome|cytosol|actin filament|plasma membrane|protein phosphorylation|calcium ion transport|transmembrane receptor protein tyrosine kinase signaling pathway|axon guidance|blood coagulation|learning|feeding behavior|regulation of cell shape|negative regulation of gene expression|negative regulation of hydrogen peroxide biosynthetic process|positive regulation of neuron projection development|positive regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|enzyme binding|cell differentiation|platelet activation|dendrite|forebrain development|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|negative regulation of protein ubiquitination|type 5 metabotropic glutamate receptor binding|intracellular signal transduction|cellular response to platelet-derived growth factor stimulus|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell population proliferation|negative regulation of protein catabolic process|response to drug|positive regulation of tyrosine phosphorylation of STAT protein|response to hydrogen peroxide|T cell receptor binding|CD4 receptor binding|CD8 receptor binding|identical protein binding|alpha-tubulin binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|cell body|ion channel binding|innate immune response|membrane raft|response to ethanol|metal ion binding|ephrin receptor binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|tau protein binding|perinuclear region of cytoplasm|dendrite morphogenesis|tau-protein kinase activity|regulation of defense response to virus by virus|regulation of peptidyl-tyrosine phosphorylation|activated T cell proliferation|modulation of chemical synaptic transmission|T cell receptor signaling pathway|leukocyte migration|detection of mechanical stimulus involved in sensory perception of pain|peptide hormone receptor binding|positive regulation of protein kinase B signaling|growth factor receptor binding|cellular response to peptide hormone stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of protein targeting to membrane|perinuclear endoplasmic reticulum|dendritic spine maintenance|glial cell projection|disordered domain specific binding|Schaffer collateral - CA1 synapse|glutamatergic synapse|postsynaptic density, intracellular component|positive regulation of protein localization to nucleus|regulation of glutamate receptor signaling pathway|positive regulation of neuron death|negative regulation of dendritic spine maintenance|negative regulation of oxidative stress-induced cell death|positive regulation of non-membrane spanning protein tyrosine kinase activity|response to amyloid-beta|cellular response to amyloid-beta|cellular response to L-glutamate|cellular response to glycine|positive regulation of protein localization to membrane|regulation of calcium ion import across plasma membrane|positive regulation of cysteine-type endopeptidase activity|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04071,hsa04072,hsa04360,hsa04380,hsa04510,hsa04520,hsa04611,hsa04650,hsa04660,hsa04664,hsa04725,hsa05020,hsa05130,hsa05416" Sphingolipid signaling pathway|Phospholipase D signaling pathway|Axon guidance|Osteoclast differentiation|Focal adhesion|Adherens junction|Platelet activation|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Cholinergic synapse|Prion disease|Pathogenic Escherichia coli infection|Viral myocarditis FYTTD1 1609.082782 1693.961511 1524.204052 0.899786708 -0.152345039 0.643938765 1 12.22821759 11.47674312 84248 forty-two-three domain containing 1 "GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0006406,GO:0016607" RNA binding|mRNA binding|protein binding|nucleoplasm|mRNA export from nucleus|nuclear speck FZD1 169.9120907 198.9313698 140.8928116 0.708248336 -0.497672789 0.382841377 1 1.461440686 1.079649247 8321 frizzled class receptor 1 "GO:0004930,GO:0005102,GO:0005109,GO:0005515,GO:0005886,GO:0005925,GO:0007186,GO:0007267,GO:0009986,GO:0010976,GO:0016021,GO:0017147,GO:0030165,GO:0030182,GO:0035425,GO:0035567,GO:0042493,GO:0042813,GO:0044338,GO:0044339,GO:0045893,GO:0051091,GO:0060070,GO:0060071,GO:0099054,GO:1904886,GO:1904953,GO:1990909" "G protein-coupled receptor activity|signaling receptor binding|frizzled binding|protein binding|plasma membrane|focal adhesion|G protein-coupled receptor signaling pathway|cell-cell signaling|cell surface|positive regulation of neuron projection development|integral component of membrane|Wnt-protein binding|PDZ domain binding|neuron differentiation|autocrine signaling|non-canonical Wnt signaling pathway|response to drug|Wnt-activated receptor activity|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt signaling pathway involved in osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|presynapse assembly|beta-catenin destruction complex disassembly|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt signalosome" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD2 1015.817762 977.4025975 1054.232926 1.078606634 0.109168812 0.758000208 1 13.09923088 14.73753378 2535 frizzled class receptor 2 "GO:0003149,GO:0003150,GO:0003151,GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0005925,GO:0007186,GO:0007223,GO:0007608,GO:0016021,GO:0016055,GO:0017147,GO:0030165,GO:0030182,GO:0030669,GO:0030855,GO:0035567,GO:0042813,GO:0045893,GO:0051091,GO:0060022,GO:0060070,GO:0060071,GO:0060119,GO:0090103,GO:0090179,GO:1904886" "membranous septum morphogenesis|muscular septum morphogenesis|outflow tract morphogenesis|G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|focal adhesion|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|sensory perception of smell|integral component of membrane|Wnt signaling pathway|Wnt-protein binding|PDZ domain binding|neuron differentiation|clathrin-coated endocytic vesicle membrane|epithelial cell differentiation|non-canonical Wnt signaling pathway|Wnt-activated receptor activity|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|hard palate development|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|inner ear receptor cell development|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|beta-catenin destruction complex disassembly" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD3 128.5930899 169.4976467 87.68853307 0.517343661 -0.950805143 0.128284961 1 2.022251556 1.091265034 7976 frizzled class receptor 3 "GO:0001736,GO:0001764,GO:0001843,GO:0001942,GO:0002052,GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0007186,GO:0007223,GO:0009986,GO:0016021,GO:0016324,GO:0016328,GO:0017147,GO:0030165,GO:0030182,GO:0030424,GO:0030425,GO:0032433,GO:0033278,GO:0035567,GO:0036342,GO:0036514,GO:0036515,GO:0042472,GO:0042493,GO:0042813,GO:0043025,GO:0045976,GO:0048786,GO:0051602,GO:0060070,GO:0060071,GO:0061549,GO:0071679,GO:1900118,GO:1904693,GO:1904938" "establishment of planar polarity|neuron migration|neural tube closure|hair follicle development|positive regulation of neuroblast proliferation|G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|cell surface|integral component of membrane|apical plasma membrane|lateral plasma membrane|Wnt-protein binding|PDZ domain binding|neuron differentiation|axon|dendrite|filopodium tip|cell proliferation in midbrain|non-canonical Wnt signaling pathway|post-anal tail morphogenesis|dopaminergic neuron axon guidance|serotonergic neuron axon guidance|inner ear morphogenesis|response to drug|Wnt-activated receptor activity|neuronal cell body|negative regulation of mitotic cell cycle, embryonic|presynaptic active zone|response to electrical stimulus|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|sympathetic ganglion development|commissural neuron axon guidance|negative regulation of execution phase of apoptosis|midbrain morphogenesis|planar cell polarity pathway involved in axon guidance" "hsa04150,hsa04310,hsa04360,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05206,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD4 242.2169401 292.3073189 192.1265612 0.657275918 -0.605428969 0.232305613 1 2.004106471 1.373992747 8322 frizzled class receptor 4 "GO:0001540,GO:0001570,GO:0004896,GO:0004930,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0005911,GO:0007186,GO:0007223,GO:0007605,GO:0009986,GO:0010812,GO:0016055,GO:0017147,GO:0019221,GO:0019955,GO:0030165,GO:0030182,GO:0030425,GO:0030665,GO:0030669,GO:0030947,GO:0031625,GO:0031987,GO:0034446,GO:0035426,GO:0035567,GO:0038023,GO:0042701,GO:0042803,GO:0042813,GO:0043507,GO:0044877,GO:0045893,GO:0046982,GO:0051091,GO:0060070,GO:0060071,GO:0061024,GO:0061299,GO:0061301,GO:0061304,GO:0071300,GO:0090090,GO:0098978,GO:0110135,GO:0150012,GO:1990830" "amyloid-beta binding|vasculogenesis|cytokine receptor activity|G protein-coupled receptor activity|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|cell-cell junction|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|sensory perception of sound|cell surface|negative regulation of cell-substrate adhesion|Wnt signaling pathway|Wnt-protein binding|cytokine-mediated signaling pathway|cytokine binding|PDZ domain binding|neuron differentiation|dendrite|clathrin-coated vesicle membrane|clathrin-coated endocytic vesicle membrane|regulation of vascular endothelial growth factor receptor signaling pathway|ubiquitin protein ligase binding|locomotion involved in locomotory behavior|substrate adhesion-dependent cell spreading|extracellular matrix-cell signaling|non-canonical Wnt signaling pathway|signaling receptor activity|progesterone secretion|protein homodimerization activity|Wnt-activated receptor activity|positive regulation of JUN kinase activity|protein-containing complex binding|positive regulation of transcription, DNA-templated|protein heterodimerization activity|positive regulation of DNA-binding transcription factor activity|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|membrane organization|retina vasculature morphogenesis in camera-type eye|cerebellum vasculature morphogenesis|retinal blood vessel morphogenesis|cellular response to retinoic acid|negative regulation of canonical Wnt signaling pathway|glutamatergic synapse|Norrin signaling pathway|positive regulation of neuron projection arborization|cellular response to leukemia inhibitory factor" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD5 170.7488973 188.7818101 152.7159846 0.808954975 -0.305868687 0.594399287 1 1.032854348 0.871524022 7855 frizzled class receptor 5 "GO:0000139,GO:0000578,GO:0001525,GO:0001540,GO:0002726,GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0005923,GO:0007186,GO:0007223,GO:0007416,GO:0008285,GO:0008289,GO:0008595,GO:0009986,GO:0016021,GO:0017147,GO:0019901,GO:0030182,GO:0030424,GO:0030425,GO:0030669,GO:0031077,GO:0031625,GO:0031901,GO:0032729,GO:0032731,GO:0032760,GO:0033077,GO:0035567,GO:0042813,GO:0043204,GO:0043507,GO:0044877,GO:0045202,GO:0045944,GO:0048469,GO:0048471,GO:0048596,GO:0060061,GO:0060070,GO:0060071,GO:0060561,GO:0060670,GO:0060715,GO:0060716,GO:0060718,GO:0071219,GO:1901382,GO:1903146,GO:1903955,GO:1904886,GO:2000810" "Golgi membrane|embryonic axis specification|angiogenesis|amyloid-beta binding|positive regulation of T cell cytokine production|G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|bicellular tight junction|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|synapse assembly|negative regulation of cell population proliferation|lipid binding|anterior/posterior axis specification, embryo|cell surface|integral component of membrane|Wnt-protein binding|protein kinase binding|neuron differentiation|axon|dendrite|clathrin-coated endocytic vesicle membrane|post-embryonic camera-type eye development|ubiquitin protein ligase binding|early endosome membrane|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of tumor necrosis factor production|T cell differentiation in thymus|non-canonical Wnt signaling pathway|Wnt-activated receptor activity|perikaryon|positive regulation of JUN kinase activity|protein-containing complex binding|synapse|positive regulation of transcription by RNA polymerase II|cell maturation|perinuclear region of cytoplasm|embryonic camera-type eye morphogenesis|Spemann organizer formation|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|apoptotic process involved in morphogenesis|branching involved in labyrinthine layer morphogenesis|syncytiotrophoblast cell differentiation involved in labyrinthine layer development|labyrinthine layer blood vessel development|chorionic trophoblast cell differentiation|cellular response to molecule of bacterial origin|regulation of chorionic trophoblast cell proliferation|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|beta-catenin destruction complex disassembly|regulation of bicellular tight junction assembly" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD6 2466.754964 2434.879368 2498.63056 1.026182485 0.037287307 0.90820689 1 33.41952581 35.7718014 8323 frizzled class receptor 6 "GO:0001540,GO:0001843,GO:0001942,GO:0004930,GO:0005515,GO:0005789,GO:0005886,GO:0005887,GO:0007186,GO:0007223,GO:0009986,GO:0016021,GO:0016324,GO:0016327,GO:0017147,GO:0030168,GO:0030659,GO:0031625,GO:0033278,GO:0035567,GO:0035880,GO:0042472,GO:0042813,GO:0043433,GO:0048105,GO:0060070,GO:0060071,GO:0090090,GO:1904693" "amyloid-beta binding|neural tube closure|hair follicle development|G protein-coupled receptor activity|protein binding|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|cell surface|integral component of membrane|apical plasma membrane|apicolateral plasma membrane|Wnt-protein binding|platelet activation|cytoplasmic vesicle membrane|ubiquitin protein ligase binding|cell proliferation in midbrain|non-canonical Wnt signaling pathway|embryonic nail plate morphogenesis|inner ear morphogenesis|Wnt-activated receptor activity|negative regulation of DNA-binding transcription factor activity|establishment of body hair planar orientation|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|negative regulation of canonical Wnt signaling pathway|midbrain morphogenesis" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD7 267.8244123 224.305269 311.3435556 1.388034962 0.473043908 0.335439008 1 2.47662319 3.585719148 8324 frizzled class receptor 7 "GO:0004930,GO:0005109,GO:0005515,GO:0005546,GO:0005886,GO:0006355,GO:0007186,GO:0010812,GO:0014834,GO:0016021,GO:0017147,GO:0019827,GO:0030165,GO:0030182,GO:0033077,GO:0034446,GO:0035567,GO:0038031,GO:0042327,GO:0042666,GO:0042813,GO:0043231,GO:0045893,GO:0046330,GO:0048103,GO:0055038,GO:0060054,GO:0060070,GO:0060071,GO:0060231,GO:0060828,GO:0071300,GO:2000726" "G protein-coupled receptor activity|frizzled binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane|regulation of transcription, DNA-templated|G protein-coupled receptor signaling pathway|negative regulation of cell-substrate adhesion|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|integral component of membrane|Wnt-protein binding|stem cell population maintenance|PDZ domain binding|neuron differentiation|T cell differentiation in thymus|substrate adhesion-dependent cell spreading|non-canonical Wnt signaling pathway|non-canonical Wnt signaling pathway via JNK cascade|positive regulation of phosphorylation|negative regulation of ectodermal cell fate specification|Wnt-activated receptor activity|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|somatic stem cell division|recycling endosome membrane|positive regulation of epithelial cell proliferation involved in wound healing|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|mesenchymal to epithelial transition|regulation of canonical Wnt signaling pathway|cellular response to retinoic acid|negative regulation of cardiac muscle cell differentiation" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD8 570.8427088 901.2808999 240.4045176 0.266736505 -1.90651281 3.11E-06 0.001004933 11.27078964 3.135831591 8325 frizzled class receptor 8 "GO:0004930,GO:0005515,GO:0005794,GO:0005886,GO:0007186,GO:0016021,GO:0017147,GO:0030165,GO:0030182,GO:0031625,GO:0035567,GO:0042813,GO:0060070" G protein-coupled receptor activity|protein binding|Golgi apparatus|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|Wnt-protein binding|PDZ domain binding|neuron differentiation|ubiquitin protein ligase binding|non-canonical Wnt signaling pathway|Wnt-activated receptor activity|canonical Wnt signaling pathway "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZR1 1481.213176 1439.207563 1523.218788 1.058373251 0.081848505 0.806859519 1 13.07927254 14.43904183 51343 fizzy and cell division cycle 20 related 1 "GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0006281,GO:0006511,GO:0007049,GO:0008284,GO:0010997,GO:0031145,GO:0031965,GO:0040020,GO:0045732,GO:0051301,GO:0070306,GO:0070979,GO:0072425,GO:0090344,GO:1901990,GO:1904668,GO:1905786,GO:1990757" protein binding|nucleoplasm|anaphase-promoting complex|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|cell cycle|positive regulation of cell population proliferation|anaphase-promoting complex binding|anaphase-promoting complex-dependent catabolic process|nuclear membrane|regulation of meiotic nuclear division|positive regulation of protein catabolic process|cell division|lens fiber cell differentiation|protein K11-linked ubiquitination|signal transduction involved in G2 DNA damage checkpoint|negative regulation of cell aging|regulation of mitotic cell cycle phase transition|positive regulation of ubiquitin protein ligase activity|positive regulation of anaphase-promoting complex-dependent catabolic process|ubiquitin ligase activator activity "hsa04110,hsa04120,hsa04914" Cell cycle|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation G0S2 10209.36584 9232.039488 11186.69219 1.211724906 0.277062206 0.411231072 1 533.7559719 674.6254358 50486 G0/G1 switch 2 "GO:0003674,GO:0005515,GO:0005739,GO:0005811,GO:0019216,GO:0097191,GO:0120162,GO:2001238" molecular_function|protein binding|mitochondrion|lipid droplet|regulation of lipid metabolic process|extrinsic apoptotic signaling pathway|positive regulation of cold-induced thermogenesis|positive regulation of extrinsic apoptotic signaling pathway G2E3 734.1578317 716.5589137 751.7567498 1.049120645 0.069180592 0.856441994 1 6.805021772 7.44682044 55632 G2/M-phase specific E3 ubiquitin protein ligase "GO:0004842,GO:0005515,GO:0005634,GO:0005730,GO:0005794,GO:0005829,GO:0006915,GO:0007275,GO:0016567,GO:0043231,GO:0046872" ubiquitin-protein transferase activity|protein binding|nucleus|nucleolus|Golgi apparatus|cytosol|apoptotic process|multicellular organism development|protein ubiquitination|intracellular membrane-bounded organelle|metal ion binding G3BP1 5686.595379 5970.985962 5402.204796 0.904742505 -0.144420844 0.655278234 1 29.56970515 27.90537852 10146 G3BP stress granule assembly factor 1 "GO:0003677,GO:0003678,GO:0003723,GO:0003724,GO:0003729,GO:0004519,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0007265,GO:0010494,GO:0016032,GO:0032508,GO:0032606,GO:0033677,GO:0034063,GO:0043204,GO:0045087,GO:0051607,GO:0062029,GO:0090305,GO:1990904" DNA binding|DNA helicase activity|RNA binding|RNA helicase activity|mRNA binding|endonuclease activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|focal adhesion|Ras protein signal transduction|cytoplasmic stress granule|viral process|DNA duplex unwinding|type I interferon production|DNA/RNA helicase activity|stress granule assembly|perikaryon|innate immune response|defense response to virus|positive regulation of stress granule assembly|nucleic acid phosphodiester bond hydrolysis|ribonucleoprotein complex G3BP2 2958.139635 3090.540924 2825.738347 0.914318372 -0.129231485 0.685121184 1 30.60715585 29.19015164 9908 G3BP stress granule assembly factor 2 "GO:0003723,GO:0003729,GO:0005515,GO:0005737,GO:0005829,GO:0007253,GO:0007265,GO:0010494,GO:0016032,GO:0030159,GO:0034063,GO:0045087,GO:0051028,GO:0051260,GO:0062029,GO:1990904" RNA binding|mRNA binding|protein binding|cytoplasm|cytosol|cytoplasmic sequestering of NF-kappaB|Ras protein signal transduction|cytoplasmic stress granule|viral process|signaling receptor complex adaptor activity|stress granule assembly|innate immune response|mRNA transport|protein homooligomerization|positive regulation of stress granule assembly|ribonucleoprotein complex G6PC3 2231.341595 2371.952098 2090.731092 0.881439003 -0.182067359 0.570050716 1 64.65608505 59.44531022 92579 glucose-6-phosphatase catalytic subunit 3 "GO:0004346,GO:0005783,GO:0005789,GO:0006094,GO:0015760,GO:0016020,GO:0016021,GO:0016311,GO:0051156" glucose-6-phosphatase activity|endoplasmic reticulum|endoplasmic reticulum membrane|gluconeogenesis|glucose-6-phosphate transport|membrane|integral component of membrane|dephosphorylation|glucose 6-phosphate metabolic process "hsa00010,hsa00052,hsa00500,hsa04068,hsa04151,hsa04152,hsa04910,hsa04920,hsa04922,hsa04931,hsa04973" Glycolysis / Gluconeogenesis|Galactose metabolism|Starch and sucrose metabolism|FoxO signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Carbohydrate digestion and absorption G6PD 3312.236543 3655.871398 2968.601687 0.812009331 -0.30043179 0.344992527 1 79.60317677 67.42288768 2539 glucose-6-phosphate dehydrogenase "GO:0004345,GO:0005515,GO:0005536,GO:0005634,GO:0005737,GO:0005829,GO:0006006,GO:0006098,GO:0006629,GO:0006695,GO:0006739,GO:0006740,GO:0006749,GO:0009051,GO:0009898,GO:0010041,GO:0010734,GO:0014070,GO:0016020,GO:0019322,GO:0021762,GO:0032094,GO:0034451,GO:0034599,GO:0042802,GO:0042803,GO:0043231,GO:0043249,GO:0043523,GO:0045471,GO:0046390,GO:0050661,GO:0051156,GO:0055114,GO:0061052,GO:0070062,GO:1904879,GO:2000378" "glucose-6-phosphate dehydrogenase activity|protein binding|glucose binding|nucleus|cytoplasm|cytosol|glucose metabolic process|pentose-phosphate shunt|lipid metabolic process|cholesterol biosynthetic process|NADP metabolic process|NADPH regeneration|glutathione metabolic process|pentose-phosphate shunt, oxidative branch|cytoplasmic side of plasma membrane|response to iron(III) ion|negative regulation of protein glutathionylation|response to organic cyclic compound|membrane|pentose biosynthetic process|substantia nigra development|response to food|centriolar satellite|cellular response to oxidative stress|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|erythrocyte maturation|regulation of neuron apoptotic process|response to ethanol|ribose phosphate biosynthetic process|NADP binding|glucose 6-phosphate metabolic process|oxidation-reduction process|negative regulation of cell growth involved in cardiac muscle cell development|extracellular exosome|positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|negative regulation of reactive oxygen species metabolic process" "hsa00030,hsa00480,hsa05230" Pentose phosphate pathway|Glutathione metabolism|Central carbon metabolism in cancer GAA 390.3074774 447.5955821 333.0193728 0.744018454 -0.426589691 0.329139756 1 6.130107412 4.757378673 2548 alpha glucosidase "GO:0000023,GO:0002026,GO:0002086,GO:0003007,GO:0004553,GO:0004558,GO:0005764,GO:0005765,GO:0005886,GO:0005980,GO:0005985,GO:0006006,GO:0007040,GO:0007626,GO:0009888,GO:0016020,GO:0030246,GO:0032450,GO:0035577,GO:0043181,GO:0043202,GO:0043231,GO:0043312,GO:0046716,GO:0050884,GO:0050885,GO:0060048,GO:0070062,GO:0070821,GO:0101003" "maltose metabolic process|regulation of the force of heart contraction|diaphragm contraction|heart morphogenesis|hydrolase activity, hydrolyzing O-glycosyl compounds|alpha-1,4-glucosidase activity|lysosome|lysosomal membrane|plasma membrane|glycogen catabolic process|sucrose metabolic process|glucose metabolic process|lysosome organization|locomotory behavior|tissue development|membrane|carbohydrate binding|maltose alpha-glucosidase activity|azurophil granule membrane|vacuolar sequestering|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|muscle cell cellular homeostasis|neuromuscular process controlling posture|neuromuscular process controlling balance|cardiac muscle contraction|extracellular exosome|tertiary granule membrane|ficolin-1-rich granule membrane" "hsa00052,hsa00500,hsa04142" Galactose metabolism|Starch and sucrose metabolism|Lysosome GAB1 330.0242393 300.4269666 359.621512 1.197034727 0.259465007 0.574570078 1 0.742983838 0.92768823 2549 GRB2 associated binding protein 1 "GO:0001525,GO:0005515,GO:0005829,GO:0005911,GO:0007173,GO:0007411,GO:0008286,GO:0014068,GO:0031532,GO:0035728,GO:0038084,GO:0038089,GO:0038128,GO:0045766,GO:0051897,GO:0090668" angiogenesis|protein binding|cytosol|cell-cell junction|epidermal growth factor receptor signaling pathway|axon guidance|insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase signaling|actin cytoskeleton reorganization|response to hepatocyte growth factor|vascular endothelial growth factor signaling pathway|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|ERBB2 signaling pathway|positive regulation of angiogenesis|positive regulation of protein kinase B signaling|endothelial cell chemotaxis to vascular endothelial growth factor "hsa01521,hsa04012,hsa04014,hsa04072,hsa04722,hsa05100,hsa05205,hsa05211,hsa05225,hsa05226" EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Neurotrophin signaling pathway|Bacterial invasion of epithelial cells|Proteoglycans in cancer|Renal cell carcinoma|Hepatocellular carcinoma|Gastric cancer GAB2 589.2376095 676.9756309 501.499588 0.740794151 -0.432855386 0.27043718 1 4.741588643 3.663847162 9846 GRB2 associated binding protein 2 "GO:0005068,GO:0005515,GO:0005547,GO:0005737,GO:0005829,GO:0005886,GO:0007169,GO:0007411,GO:0008284,GO:0019221,GO:0030316,GO:0038095,GO:0043306,GO:0043325,GO:0048015" "transmembrane receptor protein tyrosine kinase adaptor activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|axon guidance|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|osteoclast differentiation|Fc-epsilon receptor signaling pathway|positive regulation of mast cell degranulation|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-mediated signaling" "hsa04014,hsa04071,hsa04072,hsa04380,hsa04664,hsa04666,hsa05220" Ras signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Osteoclast differentiation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Chronic myeloid leukemia GAB3 26.97328364 25.37389921 28.57266808 1.126065326 0.171290524 0.902068316 1 0.371201179 0.436002382 139716 GRB2 associated binding protein 3 GO:0030225 macrophage differentiation GABARAP 3652.285387 3126.064383 4178.506391 1.336666773 0.418639851 0.188723246 1 120.0334594 167.3560453 11337 GABA type A receptor-associated protein "GO:0000045,GO:0000139,GO:0000226,GO:0000421,GO:0000422,GO:0005515,GO:0005764,GO:0005776,GO:0005790,GO:0005829,GO:0005874,GO:0005875,GO:0005886,GO:0005930,GO:0006605,GO:0006995,GO:0007268,GO:0008017,GO:0008625,GO:0015629,GO:0016236,GO:0031410,GO:0031625,GO:0044297,GO:0045202,GO:0048471,GO:0048487,GO:0050811,GO:0097225,GO:0097352" autophagosome assembly|Golgi membrane|microtubule cytoskeleton organization|autophagosome membrane|autophagy of mitochondrion|protein binding|lysosome|autophagosome|smooth endoplasmic reticulum|cytosol|microtubule|microtubule associated complex|plasma membrane|axoneme|protein targeting|cellular response to nitrogen starvation|chemical synaptic transmission|microtubule binding|extrinsic apoptotic signaling pathway via death domain receptors|actin cytoskeleton|macroautophagy|cytoplasmic vesicle|ubiquitin protein ligase binding|cell body|synapse|perinuclear region of cytoplasm|beta-tubulin binding|GABA receptor binding|sperm midpiece|autophagosome maturation "hsa04068,hsa04136,hsa04137,hsa04140,hsa04371,hsa04621,hsa04727,hsa05014,hsa05022,hsa05131,hsa05167" FoxO signaling pathway|Autophagy - other|Mitophagy - animal|Autophagy - animal|Apelin signaling pathway|NOD-like receptor signaling pathway|GABAergic synapse|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection GABARAPL1 1680.317744 1175.319011 2185.316476 1.859339001 0.894789831 0.006566479 0.328420883 25.80223739 50.04167928 23710 GABA type A receptor associated protein like 1 "GO:0000045,GO:0000421,GO:0000422,GO:0005515,GO:0005739,GO:0005776,GO:0005783,GO:0005794,GO:0005829,GO:0005874,GO:0006995,GO:0016236,GO:0030659,GO:0030957,GO:0031625,GO:0032590,GO:0032839,GO:0044297,GO:0048487,GO:0050811,GO:0097352" autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|protein binding|mitochondrion|autophagosome|endoplasmic reticulum|Golgi apparatus|cytosol|microtubule|cellular response to nitrogen starvation|macroautophagy|cytoplasmic vesicle membrane|Tat protein binding|ubiquitin protein ligase binding|dendrite membrane|dendrite cytoplasm|cell body|beta-tubulin binding|GABA receptor binding|autophagosome maturation "hsa04068,hsa04136,hsa04137,hsa04140,hsa04371,hsa04621,hsa04727,hsa05014,hsa05022,hsa05131,hsa05167" FoxO signaling pathway|Autophagy - other|Mitophagy - animal|Autophagy - animal|Apelin signaling pathway|NOD-like receptor signaling pathway|GABAergic synapse|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection GABARAPL2 832.0580292 707.42431 956.6917485 1.352359164 0.435478358 0.232401362 1 36.78495447 51.88934647 11345 GABA type A receptor associated protein like 2 "GO:0000045,GO:0000139,GO:0000149,GO:0000421,GO:0000422,GO:0005515,GO:0005737,GO:0005776,GO:0005789,GO:0005794,GO:0005829,GO:0006891,GO:0006914,GO:0006995,GO:0008017,GO:0015031,GO:0016236,GO:0031410,GO:0031625,GO:0032781,GO:0048487,GO:0050811,GO:0051117,GO:0070972,GO:0097352,GO:1901799" autophagosome assembly|Golgi membrane|SNARE binding|autophagosome membrane|autophagy of mitochondrion|protein binding|cytoplasm|autophagosome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|intra-Golgi vesicle-mediated transport|autophagy|cellular response to nitrogen starvation|microtubule binding|protein transport|macroautophagy|cytoplasmic vesicle|ubiquitin protein ligase binding|positive regulation of ATPase activity|beta-tubulin binding|GABA receptor binding|ATPase binding|protein localization to endoplasmic reticulum|autophagosome maturation|negative regulation of proteasomal protein catabolic process "hsa04068,hsa04136,hsa04137,hsa04140,hsa04371,hsa04621,hsa04727,hsa05014,hsa05022,hsa05131,hsa05167" FoxO signaling pathway|Autophagy - other|Mitophagy - animal|Autophagy - animal|Apelin signaling pathway|NOD-like receptor signaling pathway|GABAergic synapse|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection GABBR1 684.0632475 659.7213794 708.4051155 1.073794389 0.102717771 0.789634603 1 5.651650966 6.330126557 2550 gamma-aminobutyric acid type B receptor subunit 1 "GO:0004888,GO:0004965,GO:0005515,GO:0005576,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0007214,GO:0030425,GO:0038039,GO:0042734,GO:0045211,GO:0060078,GO:0098685,GO:0098982,GO:0099579,GO:0150099" transmembrane signaling receptor activity|G protein-coupled GABA receptor activity|protein binding|extracellular region|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|gamma-aminobutyric acid signaling pathway|dendrite|G protein-coupled receptor heterodimeric complex|presynaptic membrane|postsynaptic membrane|regulation of postsynaptic membrane potential|Schaffer collateral - CA1 synapse|GABA-ergic synapse|G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential|neuron-glial cell signaling "hsa04024,hsa04080,hsa04727,hsa04742,hsa04915,hsa04929,hsa05032" cAMP signaling pathway|Neuroactive ligand-receptor interaction|GABAergic synapse|Taste transduction|Estrogen signaling pathway|GnRH secretion|Morphine addiction GABBR2 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.041832633 0.01694325 9568 gamma-aminobutyric acid type B receptor subunit 2 "GO:0004888,GO:0004965,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007194,GO:0007214,GO:0007268,GO:0038039,GO:0043005,GO:0045211,GO:0046982,GO:0150099,GO:1902710" transmembrane signaling receptor activity|G protein-coupled GABA receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|G protein-coupled receptor heterodimeric complex|neuron projection|postsynaptic membrane|protein heterodimerization activity|neuron-glial cell signaling|GABA receptor complex "hsa04024,hsa04080,hsa04727,hsa04742,hsa04915,hsa04929,hsa05032" cAMP signaling pathway|Neuroactive ligand-receptor interaction|GABAergic synapse|Taste transduction|Estrogen signaling pathway|GnRH secretion|Morphine addiction GABPA 448.0466446 488.1938208 407.8994685 0.835527717 -0.259240408 0.539159418 1 4.881598179 4.254404891 2551 GA binding protein transcription factor subunit alpha "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001825,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007005,GO:0010628,GO:0030154,GO:0033613,GO:0045653,GO:0045944,GO:1903351,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blastocyst formation|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|mitochondrion organization|positive regulation of gene expression|cell differentiation|activating transcription factor binding|negative regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|cellular response to dopamine|sequence-specific double-stranded DNA binding" ETS GABPB1 566.01511 604.9137572 527.1164629 0.871391098 -0.19860772 0.618338304 1 5.989589011 5.444099723 2553 GA binding protein transcription factor subunit beta 1 "GO:0000976,GO:0005515,GO:0005634,GO:0005654,GO:0007005,GO:0036464,GO:0045944" transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|mitochondrion organization|cytoplasmic ribonucleoprotein granule|positive regulation of transcription by RNA polymerase II GABPB2 120.9094129 115.7049804 126.1138453 1.089960388 0.124275705 0.856859042 1 1.489969254 1.693963121 126626 GA binding protein transcription factor subunit beta 2 "GO:0000976,GO:0005515,GO:0005634,GO:0045944" transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|positive regulation of transcription by RNA polymerase II GABRA3 30.09238043 36.53841486 23.646346 0.64716398 -0.627796782 0.536087429 1 0.504372258 0.340472044 2556 gamma-aminobutyric acid type A receptor subunit alpha3 "GO:0004890,GO:0005237,GO:0005254,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0007214,GO:0007268,GO:0008503,GO:0022851,GO:0030594,GO:0032590,GO:0034220,GO:0034707,GO:0042391,GO:0043005,GO:0045202,GO:0050877,GO:0051932,GO:0060078,GO:0098794,GO:0098982,GO:0099060,GO:1902476,GO:1902711,GO:1904315" "GABA-A receptor activity|inhibitory extracellular ligand-gated ion channel activity|chloride channel activity|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|benzodiazepine receptor activity|GABA-gated chloride ion channel activity|neurotransmitter receptor activity|dendrite membrane|ion transmembrane transport|chloride channel complex|regulation of membrane potential|neuron projection|synapse|nervous system process|synaptic transmission, GABAergic|regulation of postsynaptic membrane potential|postsynapse|GABA-ergic synapse|integral component of postsynaptic specialization membrane|chloride transmembrane transport|GABA-A receptor complex|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" "hsa04080,hsa04723,hsa04727,hsa04742,hsa05032,hsa05033" Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Taste transduction|Morphine addiction|Nicotine addiction GABRG1 5.941278051 2.029911937 9.852644165 4.853729853 2.279093814 0.221443742 1 0.014893217 0.075401512 2565 gamma-aminobutyric acid type A receptor subunit gamma1 "GO:0004890,GO:0005237,GO:0005254,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0007214,GO:0007268,GO:0008503,GO:0022851,GO:0030594,GO:0032590,GO:0034220,GO:0034707,GO:0042391,GO:0043005,GO:0045202,GO:0045211,GO:0050811,GO:0050877,GO:0051932,GO:0060078,GO:0098794,GO:1902476,GO:1902711,GO:1904315" "GABA-A receptor activity|inhibitory extracellular ligand-gated ion channel activity|chloride channel activity|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|benzodiazepine receptor activity|GABA-gated chloride ion channel activity|neurotransmitter receptor activity|dendrite membrane|ion transmembrane transport|chloride channel complex|regulation of membrane potential|neuron projection|synapse|postsynaptic membrane|GABA receptor binding|nervous system process|synaptic transmission, GABAergic|regulation of postsynaptic membrane potential|postsynapse|chloride transmembrane transport|GABA-A receptor complex|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" "hsa04080,hsa04723,hsa04727,hsa05032,hsa05033" Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Morphine addiction|Nicotine addiction GABRR2 10.95667479 8.119647747 13.79370183 1.698805448 0.764520641 0.605113886 1 0.05159743 0.091429773 2570 gamma-aminobutyric acid type A receptor subunit rho2 "GO:0004890,GO:0005254,GO:0005886,GO:0005887,GO:0007165,GO:0007214,GO:0007268,GO:0007601,GO:0019904,GO:0030594,GO:0034220,GO:0034707,GO:0042391,GO:0043005,GO:0045202,GO:0045211,GO:0050877,GO:0060078,GO:0098982,GO:1902476,GO:1902711,GO:1904315" GABA-A receptor activity|chloride channel activity|plasma membrane|integral component of plasma membrane|signal transduction|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|visual perception|protein domain specific binding|neurotransmitter receptor activity|ion transmembrane transport|chloride channel complex|regulation of membrane potential|neuron projection|synapse|postsynaptic membrane|nervous system process|regulation of postsynaptic membrane potential|GABA-ergic synapse|chloride transmembrane transport|GABA-A receptor complex|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential "hsa04080,hsa04723,hsa04727,hsa05032,hsa05033" Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Morphine addiction|Nicotine addiction GAD1 95.23315492 111.6451565 78.82115332 0.705997069 -0.5022659 0.469675204 1 1.259619808 0.927594809 2571 glutamate decarboxylase 1 "GO:0004351,GO:0005515,GO:0005886,GO:0005938,GO:0006538,GO:0006540,GO:0007268,GO:0007269,GO:0009449,GO:0012506,GO:0016595,GO:0018352,GO:0030170,GO:0035176,GO:0035641,GO:0042136,GO:0042493,GO:0043679,GO:0044877,GO:0047485,GO:0048786,GO:0060077,GO:0061202" glutamate decarboxylase activity|protein binding|plasma membrane|cell cortex|glutamate catabolic process|glutamate decarboxylation to succinate|chemical synaptic transmission|neurotransmitter secretion|gamma-aminobutyric acid biosynthetic process|vesicle membrane|glutamate binding|protein-pyridoxal-5-phosphate linkage|pyridoxal phosphate binding|social behavior|locomotory exploration behavior|neurotransmitter biosynthetic process|response to drug|axon terminus|protein-containing complex binding|protein N-terminus binding|presynaptic active zone|inhibitory synapse|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane "hsa00250,hsa00410,hsa00430,hsa00650,hsa04727,hsa04940" "Alanine, aspartate and glutamate metabolism|beta-Alanine metabolism|Taurine and hypotaurine metabolism|Butanoate metabolism|GABAergic synapse|Type I diabetes mellitus" GADD45A 846.9179053 813.9946866 879.841124 1.080892957 0.112223657 0.759653197 1 30.49257343 34.37895687 1647 growth arrest and DNA damage inducible alpha "GO:0000079,GO:0000122,GO:0000185,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006915,GO:0006977,GO:0007050,GO:0007098,GO:0016525,GO:0016607,GO:0019900,GO:0033140,GO:0042770,GO:0042803,GO:0043065,GO:0043537,GO:0046330,GO:0046982,GO:0047485,GO:0051726,GO:0071260,GO:0071479,GO:0071850,GO:0071901,GO:1900745,GO:1990841,GO:2000379" "regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription by RNA polymerase II|activation of MAPKKK activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell cycle arrest|centrosome cycle|negative regulation of angiogenesis|nuclear speck|kinase binding|negative regulation of peptidyl-serine phosphorylation of STAT protein|signal transduction in response to DNA damage|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of blood vessel endothelial cell migration|positive regulation of JNK cascade|protein heterodimerization activity|protein N-terminus binding|regulation of cell cycle|cellular response to mechanical stimulus|cellular response to ionizing radiation|mitotic cell cycle arrest|negative regulation of protein serine/threonine kinase activity|positive regulation of p38MAPK cascade|promoter-specific chromatin binding|positive regulation of reactive oxygen species metabolic process" "hsa04010,hsa04064,hsa04068,hsa04110,hsa04115,hsa04210,hsa04218,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" MAPK signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Apoptosis|Cellular senescence|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer GADD45B 282.3928161 243.5894324 321.1961998 1.31859661 0.399003277 0.409097269 1 8.9985014 12.37650647 4616 growth arrest and DNA damage inducible beta "GO:0000185,GO:0005515,GO:0005634,GO:0005737,GO:0006915,GO:0007275,GO:0030154,GO:0043065,GO:0046330,GO:0051726,GO:1900745" activation of MAPKKK activity|protein binding|nucleus|cytoplasm|apoptotic process|multicellular organism development|cell differentiation|positive regulation of apoptotic process|positive regulation of JNK cascade|regulation of cell cycle|positive regulation of p38MAPK cascade "hsa04010,hsa04064,hsa04068,hsa04110,hsa04115,hsa04210,hsa04218,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" MAPK signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Apoptosis|Cellular senescence|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer GADD45GIP1 603.97476 640.437216 567.5123039 0.886132613 -0.174405475 0.657233011 1 18.3357183 16.94777066 90480 GADD45G interacting protein 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0005840,GO:0016032,GO:0070125,GO:0070126,GO:0071850" protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|ribosome|viral process|mitochondrial translational elongation|mitochondrial translational termination|mitotic cell cycle arrest GAK 1398.577896 1346.84657 1450.309221 1.076818439 0.106775019 0.75101069 1 11.4875425 12.90284691 2580 cyclin G associated kinase "GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0005925,GO:0006468,GO:0006898,GO:0007029,GO:0007030,GO:0007049,GO:0010977,GO:0016020,GO:0016191,GO:0030276,GO:0030332,GO:0031982,GO:0034067,GO:0043231,GO:0048471,GO:0051085,GO:0051087,GO:0061024,GO:0072318,GO:0072583,GO:0072659,GO:0090160,GO:0098793,GO:0106310,GO:0106311,GO:1905224" protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|Golgi apparatus|cytosol|focal adhesion|protein phosphorylation|receptor-mediated endocytosis|endoplasmic reticulum organization|Golgi organization|cell cycle|negative regulation of neuron projection development|membrane|synaptic vesicle uncoating|clathrin binding|cyclin binding|vesicle|protein localization to Golgi apparatus|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|chaperone cofactor-dependent protein refolding|chaperone binding|membrane organization|clathrin coat disassembly|clathrin-dependent endocytosis|protein localization to plasma membrane|Golgi to lysosome transport|presynapse|protein serine kinase activity|protein threonine kinase activity|clathrin-coated pit assembly GAL 13.50891049 14.20938356 12.80843742 0.901406973 -0.149749485 0.969790133 1 0.960821294 0.903398703 51083 galanin and GMAP prepropeptide "GO:0004966,GO:0005184,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0006954,GO:0007186,GO:0007218,GO:0007631,GO:0010737,GO:0019933,GO:0030073,GO:0030141,GO:0031763,GO:0031764,GO:0031765,GO:0031766,GO:0031943,GO:0032868,GO:0035902,GO:0042493,GO:0043025,GO:0043065,GO:0043627,GO:0045944,GO:0050672,GO:0051464,GO:0051795,GO:1902608" galanin receptor activity|neuropeptide hormone activity|protein binding|extracellular region|extracellular space|Golgi apparatus|inflammatory response|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|feeding behavior|protein kinase A signaling|cAMP-mediated signaling|insulin secretion|secretory granule|galanin receptor binding|type 1 galanin receptor binding|type 2 galanin receptor binding|type 3 galanin receptor binding|regulation of glucocorticoid metabolic process|response to insulin|response to immobilization stress|response to drug|neuronal cell body|positive regulation of apoptotic process|response to estrogen|positive regulation of transcription by RNA polymerase II|negative regulation of lymphocyte proliferation|positive regulation of cortisol secretion|positive regulation of timing of catagen|positive regulation of large conductance calcium-activated potassium channel activity hsa04080 Neuroactive ligand-receptor interaction GAL3ST1 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.053699597 0 9514 galactose-3-O-sulfotransferase 1 "GO:0000139,GO:0001733,GO:0005887,GO:0006487,GO:0006665,GO:0006681,GO:0006682,GO:0007283,GO:0008146,GO:0016020,GO:0042552,GO:0046486,GO:0050694" Golgi membrane|galactosylceramide sulfotransferase activity|integral component of plasma membrane|protein N-linked glycosylation|sphingolipid metabolic process|galactosylceramide metabolic process|galactosylceramide biosynthetic process|spermatogenesis|sulfotransferase activity|membrane|myelination|glycerolipid metabolic process|galactose 3-O-sulfotransferase activity "hsa00565,hsa00600" Ether lipid metabolism|Sphingolipid metabolism GAL3ST4 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.085495117 0.043284544 79690 galactose-3-O-sulfotransferase 4 "GO:0001733,GO:0006790,GO:0007267,GO:0008146,GO:0009100,GO:0009101,GO:0009247,GO:0009311,GO:0016020,GO:0016021,GO:0030166,GO:0032580,GO:0050656,GO:0050694,GO:0050698,GO:0070062" galactosylceramide sulfotransferase activity|sulfur compound metabolic process|cell-cell signaling|sulfotransferase activity|glycoprotein metabolic process|glycoprotein biosynthetic process|glycolipid biosynthetic process|oligosaccharide metabolic process|membrane|integral component of membrane|proteoglycan biosynthetic process|Golgi cisterna membrane|3'-phosphoadenosine 5'-phosphosulfate binding|galactose 3-O-sulfotransferase activity|proteoglycan sulfotransferase activity|extracellular exosome GALE 1046.16648 1166.184408 926.1485516 0.794169898 -0.332480417 0.341897289 1 32.47010786 26.89757223 2582 UDP-galactose-4-epimerase "GO:0003974,GO:0003978,GO:0005829,GO:0019388,GO:0033499,GO:0042802,GO:0042803" UDP-N-acetylglucosamine 4-epimerase activity|UDP-glucose 4-epimerase activity|cytosol|galactose catabolic process|galactose catabolic process via UDP-galactose|identical protein binding|protein homodimerization activity "hsa00052,hsa00520" Galactose metabolism|Amino sugar and nucleotide sugar metabolism GALK1 443.2769451 397.8627396 488.6911506 1.22829082 0.296652185 0.48297903 1 12.09504453 15.49617839 2584 galactokinase 1 "GO:0004335,GO:0005515,GO:0005524,GO:0005534,GO:0005737,GO:0005829,GO:0006012,GO:0016020,GO:0019388,GO:0019402,GO:0046835,GO:0061623,GO:0070062" galactokinase activity|protein binding|ATP binding|galactose binding|cytoplasm|cytosol|galactose metabolic process|membrane|galactose catabolic process|galactitol metabolic process|carbohydrate phosphorylation|glycolytic process from galactose|extracellular exosome "hsa00052,hsa00520" Galactose metabolism|Amino sugar and nucleotide sugar metabolism GALK2 295.1809645 309.5615704 280.8003587 0.907090497 -0.140681605 0.772532105 1 2.527111778 2.391062888 2585 galactokinase 2 "GO:0004335,GO:0005524,GO:0005829,GO:0005975,GO:0006012,GO:0033858,GO:0046835" galactokinase activity|ATP binding|cytosol|carbohydrate metabolic process|galactose metabolic process|N-acetylgalactosamine kinase activity|carbohydrate phosphorylation GALM 80.3260199 35.52345889 125.1285809 3.522421093 1.816567389 0.015100451 0.542895261 0.685385857 2.518212301 130589 galactose mutarotase "GO:0004034,GO:0005737,GO:0005975,GO:0006006,GO:0006012,GO:0030246,GO:0033499,GO:0042803,GO:0070062" aldose 1-epimerase activity|cytoplasm|carbohydrate metabolic process|glucose metabolic process|galactose metabolic process|carbohydrate binding|galactose catabolic process via UDP-galactose|protein homodimerization activity|extracellular exosome "hsa00010,hsa00052" Glycolysis / Gluconeogenesis|Galactose metabolism GALNS 695.1250805 843.4284097 546.8217512 0.648332146 -0.625194987 0.098746667 1 5.432617769 3.673860277 2588 galactosamine (N-acetyl)-6-sulfatase "GO:0003943,GO:0004065,GO:0005576,GO:0008484,GO:0035578,GO:0042340,GO:0043202,GO:0043312,GO:0043890,GO:0046872,GO:0070062" N-acetylgalactosamine-4-sulfatase activity|arylsulfatase activity|extracellular region|sulfuric ester hydrolase activity|azurophil granule lumen|keratan sulfate catabolic process|lysosomal lumen|neutrophil degranulation|N-acetylgalactosamine-6-sulfatase activity|metal ion binding|extracellular exosome "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome GALNT1 1075.088765 1089.047754 1061.129777 0.974364781 -0.037466107 0.916946685 1 11.71049402 11.90180208 2589 polypeptide N-acetylgalactosaminyltransferase 1 "GO:0000139,GO:0004653,GO:0005576,GO:0005789,GO:0005794,GO:0006493,GO:0016020,GO:0016021,GO:0016266,GO:0018215,GO:0018242,GO:0018243,GO:0030145,GO:0030246,GO:0032580,GO:0048471" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|extracellular region|endoplasmic reticulum membrane|Golgi apparatus|protein O-linked glycosylation|membrane|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|manganese ion binding|carbohydrate binding|Golgi cisterna membrane|perinuclear region of cytoplasm "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT10 937.4108062 1207.797602 667.02401 0.552264724 -0.856568116 0.016736385 0.570200991 10.2669835 5.914337417 55568 polypeptide N-acetylgalactosaminyltransferase 10 "GO:0000139,GO:0004653,GO:0005794,GO:0006493,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|protein O-linked glycosylation|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT11 654.7928279 612.0184489 697.5672069 1.139781339 0.188757077 0.62420884 1 6.408223148 7.618598698 63917 polypeptide N-acetylgalactosaminyltransferase 11 "GO:0000139,GO:0004653,GO:0005112,GO:0005794,GO:0007220,GO:0007368,GO:0008593,GO:0016021,GO:0016266,GO:0018215,GO:0018243,GO:0030246,GO:0046872,GO:0060271,GO:0061314" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Notch binding|Golgi apparatus|Notch receptor processing|determination of left/right symmetry|regulation of Notch signaling pathway|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|protein O-linked glycosylation via threonine|carbohydrate binding|metal ion binding|cilium assembly|Notch signaling involved in heart development "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT12 17.50935126 18.26920743 16.74949508 0.916815639 -0.125296441 0.967778525 1 0.229880971 0.219837089 79695 polypeptide N-acetylgalactosaminyltransferase 12 "GO:0000139,GO:0004653,GO:0005794,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT14 257.0283195 260.8436839 253.2129551 0.970745971 -0.042834281 0.939491189 1 4.090034795 4.141412871 79623 polypeptide N-acetylgalactosaminyltransferase 14 "GO:0000139,GO:0004653,GO:0005794,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT16 173.0663222 145.1387035 200.993941 1.384840405 0.469719724 0.407693552 1 0.933074805 1.34782069 57452 polypeptide N-acetylgalactosaminyltransferase 16 "GO:0000139,GO:0004653,GO:0005794,GO:0016021,GO:0018215,GO:0018242,GO:0018243,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|integral component of membrane|protein phosphopantetheinylation|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT18 5.030242514 7.104691779 2.95579325 0.416033987 -1.265226703 0.543955984 1 0.023826485 0.010339623 374378 polypeptide N-acetylgalactosaminyltransferase 18 "GO:0000139,GO:0004653,GO:0005575,GO:0005794,GO:0006493,GO:0016021,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|cellular_component|Golgi apparatus|protein O-linked glycosylation|integral component of membrane|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT2 3067.814509 2943.372308 3192.25671 1.084557567 0.117106632 0.7132974 1 23.69221612 26.80243331 2590 polypeptide N-acetylgalactosaminyltransferase 2 "GO:0000139,GO:0004653,GO:0005515,GO:0005576,GO:0005789,GO:0005794,GO:0005795,GO:0006493,GO:0016020,GO:0016266,GO:0018215,GO:0018242,GO:0018243,GO:0030145,GO:0030173,GO:0030246,GO:0032580,GO:0048471,GO:0051604" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|protein binding|extracellular region|endoplasmic reticulum membrane|Golgi apparatus|Golgi stack|protein O-linked glycosylation|membrane|O-glycan processing|protein phosphopantetheinylation|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|manganese ion binding|integral component of Golgi membrane|carbohydrate binding|Golgi cisterna membrane|perinuclear region of cytoplasm|protein maturation "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT3 6.478447587 5.074779842 7.882115332 1.553193553 0.635237624 0.773446698 1 0.043629213 0.070683638 2591 polypeptide N-acetylgalactosaminyltransferase 3 "GO:0000139,GO:0004653,GO:0005509,GO:0005794,GO:0005975,GO:0008543,GO:0016020,GO:0016021,GO:0016266,GO:0018215,GO:0018242,GO:0018243,GO:0030145,GO:0030246,GO:0032580,GO:0048471,GO:0070062" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|calcium ion binding|Golgi apparatus|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|membrane|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|manganese ion binding|carbohydrate binding|Golgi cisterna membrane|perinuclear region of cytoplasm|extracellular exosome "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT4 17.0464106 20.29911937 13.79370183 0.679522179 -0.557407454 0.661192297 1 0.19091528 0.13531946 8693 polypeptide N-acetylgalactosaminyltransferase 4 "GO:0000139,GO:0004653,GO:0005515,GO:0005794,GO:0016021,GO:0016266,GO:0018215,GO:0018242,GO:0018243,GO:0030145,GO:0030246,GO:0048471,GO:0070062" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|protein binding|Golgi apparatus|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|manganese ion binding|carbohydrate binding|perinuclear region of cytoplasm|extracellular exosome "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT5 11.92709343 7.104691779 16.74949508 2.357525928 1.237273638 0.360469127 1 0.034084264 0.083815884 11227 polypeptide N-acetylgalactosaminyltransferase 5 "GO:0000139,GO:0004653,GO:0005575,GO:0005794,GO:0006024,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|cellular_component|Golgi apparatus|glycosaminoglycan biosynthetic process|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT6 2006.173541 2436.90928 1575.437802 0.646490132 -0.629299746 0.051305833 1 21.33832264 14.38924832 11226 polypeptide N-acetylgalactosaminyltransferase 6 "GO:0000139,GO:0004653,GO:0005515,GO:0005794,GO:0006493,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872,GO:0048471" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|protein binding|Golgi apparatus|protein O-linked glycosylation|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding|perinuclear region of cytoplasm "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT7 1341.709186 1433.117827 1250.300545 0.872433879 -0.196882301 0.559131213 1 9.702227272 8.829170331 51809 polypeptide N-acetylgalactosaminyltransferase 7 "GO:0000139,GO:0004653,GO:0005794,GO:0005975,GO:0006493,GO:0016020,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872,GO:0070062" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|carbohydrate metabolic process|protein O-linked glycosylation|membrane|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding|extracellular exosome "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALR2 4.059823873 8.119647747 0 0 #NAME? 0.065967888 1 0.143938227 0 8811 galanin receptor 2 "GO:0004966,GO:0005515,GO:0005886,GO:0005887,GO:0005929,GO:0006936,GO:0007166,GO:0007186,GO:0007188,GO:0007189,GO:0007194,GO:0007200,GO:0007204,GO:0007218,GO:0007275,GO:0007611,GO:0007631,GO:0008528,GO:0016021,GO:0017046,GO:0031175,GO:0042923,GO:0043647,GO:0045944,GO:0046488,GO:0090663,GO:1902608" galanin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cilium|muscle contraction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|multicellular organism development|learning or memory|feeding behavior|G protein-coupled peptide receptor activity|integral component of membrane|peptide hormone binding|neuron projection development|neuropeptide binding|inositol phosphate metabolic process|positive regulation of transcription by RNA polymerase II|phosphatidylinositol metabolic process|galanin-activated signaling pathway|positive regulation of large conductance calcium-activated potassium channel activity hsa04080 Neuroactive ligand-receptor interaction GALT 822.8558776 785.5759195 860.1358356 1.094911153 0.130813806 0.722380265 1 22.65754498 25.87662666 2592 galactose-1-phosphate uridylyltransferase "GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0006011,GO:0006012,GO:0006258,GO:0008108,GO:0008270,GO:0019388,GO:0033499" protein binding|cytoplasm|Golgi apparatus|cytosol|UDP-glucose metabolic process|galactose metabolic process|UDP-glucose catabolic process|UDP-glucose:hexose-1-phosphate uridylyltransferase activity|zinc ion binding|galactose catabolic process|galactose catabolic process via UDP-galactose "hsa00052,hsa00520,hsa04917" Galactose metabolism|Amino sugar and nucleotide sugar metabolism|Prolactin signaling pathway GAMT 48.42369257 43.64310664 53.20427849 1.219076335 0.285788466 0.755820553 1 0.999714784 1.271226522 2593 guanidinoacetate N-methyltransferase "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006600,GO:0006601,GO:0006936,GO:0007283,GO:0008168,GO:0008757,GO:0009887,GO:0030731,GO:0032259,GO:0040014" protein binding|nucleus|cytoplasm|cytosol|creatine metabolic process|creatine biosynthetic process|muscle contraction|spermatogenesis|methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|animal organ morphogenesis|guanidinoacetate N-methyltransferase activity|methylation|regulation of multicellular organism growth "hsa00260,hsa00330" "Glycine, serine and threonine metabolism|Arginine and proline metabolism" GAN 189.7361452 207.0510175 172.4212729 0.832747769 -0.264048511 0.634898106 1 0.691760908 0.600876783 8139 gigaxonin "GO:0003674,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0007010,GO:0016567,GO:0031463,GO:0043687" molecular_function|protein binding|cytoplasm|cytosol|cytoskeleton|cytoskeleton organization|protein ubiquitination|Cul3-RING ubiquitin ligase complex|post-translational protein modification GANAB 18902.73881 16802.59606 21002.88157 1.249978366 0.321903126 0.372644347 1 202.9070611 264.5547642 23193 glucosidase II alpha subunit "GO:0003723,GO:0004553,GO:0005515,GO:0005788,GO:0005794,GO:0005975,GO:0006457,GO:0006491,GO:0016020,GO:0017177,GO:0030246,GO:0033919,GO:0042470,GO:0043231,GO:0070062,GO:0090599" "RNA binding|hydrolase activity, hydrolyzing O-glycosyl compounds|protein binding|endoplasmic reticulum lumen|Golgi apparatus|carbohydrate metabolic process|protein folding|N-glycan processing|membrane|glucosidase II complex|carbohydrate binding|glucan 1,3-alpha-glucosidase activity|melanosome|intracellular membrane-bounded organelle|extracellular exosome|alpha-glucosidase activity" "hsa00510,hsa04141" N-Glycan biosynthesis|Protein processing in endoplasmic reticulum GANC 244.4277229 275.0530674 213.8023784 0.777313194 -0.36343209 0.47369178 1 2.015403289 1.634082324 2595 "glucosidase alpha, neutral C" "GO:0000023,GO:0004553,GO:0004558,GO:0006491,GO:0030246,GO:0032450,GO:0090599" "maltose metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|alpha-1,4-glucosidase activity|N-glycan processing|carbohydrate binding|maltose alpha-glucosidase activity|alpha-glucosidase activity" "hsa00052,hsa00500" Galactose metabolism|Starch and sucrose metabolism GAP43 8.015727316 9.134603715 6.896850916 0.755024644 -0.405404361 0.864587159 1 0.129917285 0.102316104 2596 growth associated protein 43 "GO:0001786,GO:0005515,GO:0005516,GO:0005737,GO:0005886,GO:0007205,GO:0009611,GO:0010001,GO:0014069,GO:0016198,GO:0030425,GO:0031103,GO:0031527,GO:0032584,GO:0035727,GO:0040008,GO:0042246,GO:0043204,GO:0045165,GO:0051489,GO:0098982,GO:0099150,GO:1901981" phosphatidylserine binding|protein binding|calmodulin binding|cytoplasm|plasma membrane|protein kinase C-activating G protein-coupled receptor signaling pathway|response to wounding|glial cell differentiation|postsynaptic density|axon choice point recognition|dendrite|axon regeneration|filopodium membrane|growth cone membrane|lysophosphatidic acid binding|regulation of growth|tissue regeneration|perikaryon|cell fate commitment|regulation of filopodium assembly|GABA-ergic synapse|regulation of postsynaptic specialization assembly|phosphatidylinositol phosphate binding GAPDH 111742.4665 128399.0347 95085.89831 0.740549947 -0.433331053 0.385925954 1 4361.474274 3369.020084 2597 glyceraldehyde-3-phosphate dehydrogenase "GO:0000226,GO:0001819,GO:0004365,GO:0005515,GO:0005634,GO:0005737,GO:0005811,GO:0005829,GO:0005886,GO:0006094,GO:0006096,GO:0008017,GO:0010951,GO:0015630,GO:0016020,GO:0016241,GO:0017148,GO:0019828,GO:0031640,GO:0031965,GO:0031982,GO:0035605,GO:0035606,GO:0042802,GO:0043231,GO:0048471,GO:0050661,GO:0050821,GO:0050832,GO:0051287,GO:0051402,GO:0051873,GO:0061621,GO:0061844,GO:0070062,GO:0071346,GO:0097452,GO:0097718,GO:1990904" microtubule cytoskeleton organization|positive regulation of cytokine production|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|protein binding|nucleus|cytoplasm|lipid droplet|cytosol|plasma membrane|gluconeogenesis|glycolytic process|microtubule binding|negative regulation of endopeptidase activity|microtubule cytoskeleton|membrane|regulation of macroautophagy|negative regulation of translation|aspartic-type endopeptidase inhibitor activity|killing of cells of other organism|nuclear membrane|vesicle|peptidyl-cysteine S-nitrosylase activity|peptidyl-cysteine S-trans-nitrosylation|identical protein binding|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|NADP binding|protein stabilization|defense response to fungus|NAD binding|neuron apoptotic process|killing by host of symbiont cells|canonical glycolysis|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome|cellular response to interferon-gamma|GAIT complex|disordered domain specific binding|ribonucleoprotein complex "hsa00010,hsa04066,hsa05010,hsa05130,hsa05132" Glycolysis / Gluconeogenesis|HIF-1 signaling pathway|Alzheimer disease|Pathogenic Escherichia coli infection|Salmonella infection GAPVD1 2177.927 2020.777333 2335.076667 1.155533878 0.208559557 0.515657013 1 13.92641761 16.78564471 26130 GTPase activating protein and VPS9 domains 1 "GO:0005085,GO:0005096,GO:0005768,GO:0005829,GO:0005886,GO:0006897,GO:0007165,GO:0032794,GO:0043547,GO:0045296,GO:0051223,GO:0061024" guanyl-nucleotide exchange factor activity|GTPase activator activity|endosome|cytosol|plasma membrane|endocytosis|signal transduction|GTPase activating protein binding|positive regulation of GTPase activity|cadherin binding|regulation of protein transport|membrane organization GAR1 335.8291838 326.8158218 344.8425458 1.055158664 0.077459952 0.871332087 1 15.74887577 17.33337992 54433 GAR1 ribonucleoprotein "GO:0000454,GO:0000781,GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005697,GO:0007004,GO:0031118,GO:0031429,GO:0034513,GO:0070034,GO:0072589,GO:0090661" "snoRNA guided rRNA pseudouridine synthesis|chromosome, telomeric region|fibrillar center|RNA binding|protein binding|nucleoplasm|telomerase holoenzyme complex|telomere maintenance via telomerase|rRNA pseudouridine synthesis|box H/ACA snoRNP complex|box H/ACA snoRNA binding|telomerase RNA binding|box H/ACA scaRNP complex|box H/ACA telomerase RNP complex" hsa03008 Ribosome biogenesis in eukaryotes GAREM1 164.7455146 216.1856213 113.3054079 0.524111674 -0.932053851 0.105585395 1 1.27670698 0.697960742 64762 GRB2 associated regulator of MAPK1 subtype 1 "GO:0005515,GO:0005886,GO:0007173,GO:0008284,GO:0051781,GO:0070064,GO:0070374,GO:0071364" protein binding|plasma membrane|epidermal growth factor receptor signaling pathway|positive regulation of cell population proliferation|positive regulation of cell division|proline-rich region binding|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus GAREM2 76.21893709 57.8524902 94.58538399 1.634940582 0.709238205 0.34099357 1 0.435561846 0.742792882 150946 GRB2 associated regulator of MAPK1 subtype 2 GARNL3 61.64781171 72.06187375 51.23374966 0.71096888 -0.492141683 0.542438205 1 0.624090234 0.462821907 84253 GTPase activating Rap/RanGAP domain like 3 "GO:0005096,GO:0005737,GO:0051056,GO:0090630" GTPase activator activity|cytoplasm|regulation of small GTPase mediated signal transduction|activation of GTPase activity GARRE1 396.1678456 343.0551173 449.2805739 1.309645451 0.389176297 0.371566835 1 2.600977764 3.553090816 9710 granule associated Rac and RHOG effector 1 "GO:0000932,GO:0005515,GO:0016601,GO:0031267,GO:1905762" P-body|protein binding|Rac protein signal transduction|small GTPase binding|CCR4-NOT complex binding GARS1 3983.587846 3311.801325 4655.374368 1.405692525 0.491281061 0.123706013 1 62.35355159 91.42552454 2617 glycyl-tRNA synthetase 1 "GO:0004081,GO:0004820,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006418,GO:0006426,GO:0015966,GO:0016740,GO:0030424,GO:0042802,GO:0046983,GO:0070062,GO:0070150" bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity|glycine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|tRNA aminoacylation for protein translation|glycyl-tRNA aminoacylation|diadenosine tetraphosphate biosynthetic process|transferase activity|axon|identical protein binding|protein dimerization activity|extracellular exosome|mitochondrial glycyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis GART 2614.713127 2749.515718 2479.910536 0.901944484 -0.148889458 0.640891956 1 31.46966586 29.60655447 2618 "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" "GO:0003360,GO:0004637,GO:0004641,GO:0004644,GO:0005524,GO:0005829,GO:0006164,GO:0006189,GO:0006544,GO:0009168,GO:0010033,GO:0010035,GO:0021549,GO:0021987,GO:0046084,GO:0046654,GO:0046872,GO:0070062" brainstem development|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|ATP binding|cytosol|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|glycine metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to organic substance|response to inorganic substance|cerebellum development|cerebral cortex development|adenine biosynthetic process|tetrahydrofolate biosynthetic process|metal ion binding|extracellular exosome "hsa00230,hsa00670,hsa01523" Purine metabolism|One carbon pool by folate|Antifolate resistance GAS1 9.478778165 8.119647747 10.83790858 1.334775709 0.416597337 0.834100552 1 0.130757238 0.182049698 2619 growth arrest specific 1 "GO:0005515,GO:0005886,GO:0007050,GO:0008589,GO:0010955,GO:0016021,GO:0035924,GO:0042981,GO:0045165,GO:0045930,GO:0046658,GO:0048589,GO:0060628" protein binding|plasma membrane|cell cycle arrest|regulation of smoothened signaling pathway|negative regulation of protein processing|integral component of membrane|cellular response to vascular endothelial growth factor stimulus|regulation of apoptotic process|cell fate commitment|negative regulation of mitotic cell cycle|anchored component of plasma membrane|developmental growth|regulation of ER to Golgi vesicle-mediated transport hsa04340 Hedgehog signaling pathway GAS2L1 714.8615442 643.4820839 786.2410044 1.221853761 0.289071625 0.442714093 1 9.737107106 12.40980927 10634 growth arrest specific 2 like 1 "GO:0000226,GO:0001578,GO:0005515,GO:0005737,GO:0005884,GO:0007050,GO:0008017,GO:0008093,GO:0009267,GO:0031110,GO:0035371,GO:0046966,GO:0051015,GO:0051764,GO:0097067,GO:1904825" microtubule cytoskeleton organization|microtubule bundle formation|protein binding|cytoplasm|actin filament|cell cycle arrest|microtubule binding|cytoskeletal anchor activity|cellular response to starvation|regulation of microtubule polymerization or depolymerization|microtubule plus-end|thyroid hormone receptor binding|actin filament binding|actin crosslink formation|cellular response to thyroid hormone stimulus|protein localization to microtubule plus-end GAS2L3 390.8528118 350.1598091 431.5458144 1.232425319 0.301500227 0.491368181 1 4.025047445 5.174251635 283431 growth arrest specific 2 like 3 "GO:0000226,GO:0003779,GO:0005515,GO:0005737,GO:0005874,GO:0005884,GO:0008017,GO:0008093,GO:0015629,GO:0015630,GO:0030036,GO:0051015,GO:0051764" microtubule cytoskeleton organization|actin binding|protein binding|cytoplasm|microtubule|actin filament|microtubule binding|cytoskeletal anchor activity|actin cytoskeleton|microtubule cytoskeleton|actin cytoskeleton organization|actin filament binding|actin crosslink formation GAS6 2103.092926 1821.845963 2384.339888 1.308749442 0.388188922 0.22703714 1 36.79029942 50.22335972 2621 growth arrest specific 6 "GO:0001764,GO:0001786,GO:0001934,GO:0001961,GO:0002576,GO:0003104,GO:0005102,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005788,GO:0005796,GO:0006468,GO:0006888,GO:0006909,GO:0006915,GO:0007165,GO:0007167,GO:0007596,GO:0009267,GO:0010628,GO:0010804,GO:0018105,GO:0019064,GO:0019079,GO:0030296,GO:0030674,GO:0030971,GO:0031093,GO:0031100,GO:0031589,GO:0032008,GO:0032148,GO:0032689,GO:0032692,GO:0032715,GO:0032720,GO:0032825,GO:0033138,GO:0035457,GO:0035690,GO:0035754,GO:0040008,GO:0043027,GO:0043066,GO:0043154,GO:0043277,GO:0043433,GO:0043491,GO:0043687,GO:0044267,GO:0045860,GO:0045892,GO:0046718,GO:0046813,GO:0046827,GO:0048018,GO:0048146,GO:0050766,GO:0050900,GO:0051897,GO:0061098,GO:0070062,GO:0070168,GO:0070374,GO:0070588,GO:0071307,GO:0071333,GO:0071363,GO:0072659,GO:0085029,GO:0097028,GO:0097241,GO:1900142,GO:2000270,GO:2000352,GO:2000510,GO:2000533,GO:2000669" "neuron migration|phosphatidylserine binding|positive regulation of protein phosphorylation|positive regulation of cytokine-mediated signaling pathway|platelet degranulation|positive regulation of glomerular filtration|signaling receptor binding|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum lumen|Golgi lumen|protein phosphorylation|endoplasmic reticulum to Golgi vesicle-mediated transport|phagocytosis|apoptotic process|signal transduction|enzyme linked receptor protein signaling pathway|blood coagulation|cellular response to starvation|positive regulation of gene expression|negative regulation of tumor necrosis factor-mediated signaling pathway|peptidyl-serine phosphorylation|fusion of virus membrane with host plasma membrane|viral genome replication|protein tyrosine kinase activator activity|protein-macromolecule adaptor activity|receptor tyrosine kinase binding|platelet alpha granule lumen|animal organ regeneration|cell-substrate adhesion|positive regulation of TOR signaling|activation of protein kinase B activity|negative regulation of interferon-gamma production|negative regulation of interleukin-1 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of natural killer cell differentiation|positive regulation of peptidyl-serine phosphorylation|cellular response to interferon-alpha|cellular response to drug|B cell chemotaxis|regulation of growth|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|apoptotic cell clearance|negative regulation of DNA-binding transcription factor activity|protein kinase B signaling|post-translational protein modification|cellular protein metabolic process|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|viral entry into host cell|receptor-mediated virion attachment to host cell|positive regulation of protein export from nucleus|receptor ligand activity|positive regulation of fibroblast proliferation|positive regulation of phagocytosis|leukocyte migration|positive regulation of protein kinase B signaling|positive regulation of protein tyrosine kinase activity|extracellular exosome|negative regulation of biomineral tissue development|positive regulation of ERK1 and ERK2 cascade|calcium ion transmembrane transport|cellular response to vitamin K|cellular response to glucose stimulus|cellular response to growth factor stimulus|protein localization to plasma membrane|extracellular matrix assembly|dendritic cell differentiation|hematopoietic stem cell migration to bone marrow|negative regulation of oligodendrocyte apoptotic process|negative regulation of fibroblast apoptotic process|negative regulation of endothelial cell apoptotic process|positive regulation of dendritic cell chemotaxis|negative regulation of renal albumin absorption|negative regulation of dendritic cell apoptotic process" hsa01521 EGFR tyrosine kinase inhibitor resistance GAS8 463.365502 457.7451417 468.9858623 1.024556723 0.034999859 0.938465376 1 4.249115946 4.540989722 2622 growth arrest specific 8 "GO:0003674,GO:0005515,GO:0005794,GO:0005829,GO:0005874,GO:0005886,GO:0005929,GO:0005930,GO:0008017,GO:0008285,GO:0030317,GO:0031514,GO:0034613,GO:0035082,GO:0036064,GO:0045880,GO:0060294,GO:1903566,GO:1904526" molecular_function|protein binding|Golgi apparatus|cytosol|microtubule|plasma membrane|cilium|axoneme|microtubule binding|negative regulation of cell population proliferation|flagellated sperm motility|motile cilium|cellular protein localization|axoneme assembly|ciliary basal body|positive regulation of smoothened signaling pathway|cilium movement involved in cell motility|positive regulation of protein localization to cilium|regulation of microtubule binding GASK1A 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.015167878 0.046075241 729085 golgi associated kinase 1A "GO:0005576,GO:0005783,GO:0005794,GO:0005901,GO:0043231" extracellular region|endoplasmic reticulum|Golgi apparatus|caveola|intracellular membrane-bounded organelle GASK1B 7.060154451 11.16451565 2.95579325 0.264748901 -1.917303399 0.254779046 1 0.105967641 0.029263304 51313 golgi associated kinase 1B "GO:0000139,GO:0005794,GO:0016021" Golgi membrane|Golgi apparatus|integral component of membrane GATA2 125.3903617 85.25630134 165.524422 1.941491941 0.957165719 0.129169118 1 1.142914478 2.314543013 2624 GATA binding protein 2 "GO:0000122,GO:0000978,GO:0000981,GO:0001228,GO:0001655,GO:0001709,GO:0001764,GO:0001892,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006909,GO:0007204,GO:0007596,GO:0008134,GO:0008270,GO:0010628,GO:0010629,GO:0010725,GO:0021514,GO:0021533,GO:0021902,GO:0021954,GO:0021983,GO:0033993,GO:0035019,GO:0035065,GO:0035854,GO:0042472,GO:0043306,GO:0043536,GO:0045165,GO:0045599,GO:0045648,GO:0045650,GO:0045654,GO:0045666,GO:0045746,GO:0045766,GO:0045944,GO:0048469,GO:0048873,GO:0050766,GO:0060100,GO:0060216,GO:0060872,GO:0061042,GO:0070345,GO:0070742,GO:0090050,GO:0090102,GO:0097154,GO:1902036,GO:1902895,GO:1903589,GO:1990837,GO:2000178,GO:2000352,GO:2000977" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|urogenital system development|cell fate determination|neuron migration|embryonic placenta development|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|phagocytosis|positive regulation of cytosolic calcium ion concentration|blood coagulation|transcription factor binding|zinc ion binding|positive regulation of gene expression|negative regulation of gene expression|regulation of primitive erythrocyte differentiation|ventral spinal cord interneuron differentiation|cell differentiation in hindbrain|commitment of neuronal cell to specific neuron type in forebrain|central nervous system neuron development|pituitary gland development|response to lipid|somatic stem cell population maintenance|regulation of histone acetylation|eosinophil fate commitment|inner ear morphogenesis|positive regulation of mast cell degranulation|positive regulation of blood vessel endothelial cell migration|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of erythrocyte differentiation|negative regulation of macrophage differentiation|positive regulation of megakaryocyte differentiation|positive regulation of neuron differentiation|negative regulation of Notch signaling pathway|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|cell maturation|homeostasis of number of cells within a tissue|positive regulation of phagocytosis|positive regulation of phagocytosis, engulfment|definitive hemopoiesis|semicircular canal development|vascular wound healing|negative regulation of fat cell proliferation|C2H2 zinc finger domain binding|positive regulation of cell migration involved in sprouting angiogenesis|cochlea development|GABAergic neuron differentiation|regulation of hematopoietic stem cell differentiation|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|sequence-specific double-stranded DNA binding|negative regulation of neural precursor cell proliferation|negative regulation of endothelial cell apoptotic process|regulation of forebrain neuron differentiation" zf-GATA GATA3 66.60382534 74.09178569 59.11586499 0.7978734 -0.325768245 0.685296588 1 1.120480013 0.932511144 2625 GATA binding protein 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001227,GO:0001228,GO:0001701,GO:0001709,GO:0001764,GO:0001806,GO:0001817,GO:0001822,GO:0001823,GO:0002088,GO:0002520,GO:0002572,GO:0003180,GO:0003215,GO:0003281,GO:0003677,GO:0003700,GO:0005134,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0006952,GO:0006959,GO:0007165,GO:0007411,GO:0007596,GO:0008134,GO:0008270,GO:0008285,GO:0008584,GO:0009615,GO:0009653,GO:0009791,GO:0009967,GO:0010332,GO:0010595,GO:0010719,GO:0010975,GO:0014065,GO:0016579,GO:0019221,GO:0030217,GO:0030218,GO:0030856,GO:0031929,GO:0032689,GO:0032703,GO:0032736,GO:0032753,GO:0032754,GO:0033600,GO:0035162,GO:0035457,GO:0035799,GO:0035898,GO:0042421,GO:0042472,GO:0042493,GO:0042802,GO:0043370,GO:0043523,GO:0043583,GO:0043627,GO:0045061,GO:0045064,GO:0045087,GO:0045165,GO:0045471,GO:0045582,GO:0045599,GO:0045786,GO:0045892,GO:0045893,GO:0045944,GO:0048469,GO:0048485,GO:0048538,GO:0048568,GO:0048589,GO:0048646,GO:0050728,GO:0050852,GO:0051569,GO:0051897,GO:0060017,GO:0060037,GO:0060065,GO:0060231,GO:0060374,GO:0060676,GO:0061085,GO:0061290,GO:0070888,GO:0071353,GO:0071356,GO:0071442,GO:0071599,GO:0071773,GO:0071837,GO:0072107,GO:0072178,GO:0072179,GO:0072182,GO:0072197,GO:0072676,GO:0090102,GO:1901536,GO:1902036,GO:1902895,GO:1990837,GO:2000114,GO:2000146,GO:2000352,GO:2000553,GO:2000607,GO:2000611,GO:2000617,GO:2000679,GO:2000683,GO:2000703,GO:2000734" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|cell fate determination|neuron migration|type IV hypersensitivity|regulation of cytokine production|kidney development|mesonephros development|lens development in camera-type eye|immune system development|pro-T cell differentiation|aortic valve morphogenesis|cardiac right ventricle morphogenesis|ventricular septum development|DNA binding|DNA-binding transcription factor activity|interleukin-2 receptor binding|protein binding|nucleus|nucleoplasm|chromatin remodeling|defense response|humoral immune response|signal transduction|axon guidance|blood coagulation|transcription factor binding|zinc ion binding|negative regulation of cell population proliferation|male gonad development|response to virus|anatomical structure morphogenesis|post-embryonic development|positive regulation of signal transduction|response to gamma radiation|positive regulation of endothelial cell migration|negative regulation of epithelial to mesenchymal transition|regulation of neuron projection development|phosphatidylinositol 3-kinase signaling|protein deubiquitination|cytokine-mediated signaling pathway|T cell differentiation|erythrocyte differentiation|regulation of epithelial cell differentiation|TOR signaling|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|negative regulation of mammary gland epithelial cell proliferation|embryonic hemopoiesis|cellular response to interferon-alpha|ureter maturation|parathyroid hormone secretion|norepinephrine biosynthetic process|inner ear morphogenesis|response to drug|identical protein binding|regulation of CD4-positive, alpha-beta T cell differentiation|regulation of neuron apoptotic process|ear development|response to estrogen|thymic T cell selection|T-helper 2 cell differentiation|innate immune response|cell fate commitment|response to ethanol|positive regulation of T cell differentiation|negative regulation of fat cell differentiation|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell maturation|sympathetic nervous system development|thymus development|embryonic organ development|developmental growth|anatomical structure formation involved in morphogenesis|negative regulation of inflammatory response|T cell receptor signaling pathway|regulation of histone H3-K4 methylation|positive regulation of protein kinase B signaling|parathyroid gland development|pharyngeal system development|uterus development|mesenchymal to epithelial transition|mast cell differentiation|ureteric bud formation|regulation of histone H3-K27 methylation|canonical Wnt signaling pathway involved in metanephric kidney development|E-box binding|cellular response to interleukin-4|cellular response to tumor necrosis factor|positive regulation of histone H3-K14 acetylation|otic vesicle development|cellular response to BMP stimulus|HMG box domain binding|positive regulation of ureteric bud formation|nephric duct morphogenesis|nephric duct formation|regulation of nephron tubule epithelial cell differentiation|ureter morphogenesis|lymphocyte migration|cochlea development|negative regulation of DNA demethylation|regulation of hematopoietic stem cell differentiation|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding|regulation of establishment of cell polarity|negative regulation of cell motility|negative regulation of endothelial cell apoptotic process|positive regulation of T-helper 2 cell cytokine production|negative regulation of cell proliferation involved in mesonephros development|positive regulation of thyroid hormone generation|positive regulation of histone H3-K9 acetylation|positive regulation of transcription regulatory region DNA binding|regulation of cellular response to X-ray|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation" "hsa04658,hsa04659,hsa04928,hsa05321" "Th1 and Th2 cell differentiation|Th17 cell differentiation|Parathyroid hormone synthesis, secretion and action|Inflammatory bowel disease" zf-GATA GATA4 52.91676554 47.70293051 58.13060058 1.218596006 0.285219916 0.747974253 1 0.539402801 0.685628524 2626 GATA binding protein 4 "GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001085,GO:0001216,GO:0001228,GO:0001947,GO:0003180,GO:0003190,GO:0003197,GO:0003208,GO:0003215,GO:0003281,GO:0003289,GO:0003290,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0007267,GO:0007492,GO:0007596,GO:0008134,GO:0008270,GO:0008584,GO:0009612,GO:0010507,GO:0010575,GO:0010667,GO:0016604,GO:0019901,GO:0030513,GO:0033189,GO:0033613,GO:0035054,GO:0042060,GO:0042493,GO:0043565,GO:0045165,GO:0045766,GO:0045893,GO:0045944,GO:0048617,GO:0051525,GO:0051891,GO:0051896,GO:0060290,GO:0060413,GO:0060575,GO:0061026,GO:0061049,GO:0070374,GO:0070410,GO:0071333,GO:0086004,GO:0090575,GO:1903202,GO:1990837,GO:2001234" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|heart looping|aortic valve morphogenesis|atrioventricular valve formation|endocardial cushion development|cardiac ventricle morphogenesis|cardiac right ventricle morphogenesis|ventricular septum development|atrial septum primum morphogenesis|atrial septum secundum morphogenesis|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|cell-cell signaling|endoderm development|blood coagulation|transcription factor binding|zinc ion binding|male gonad development|response to mechanical stimulus|negative regulation of autophagy|positive regulation of vascular endothelial growth factor production|negative regulation of cardiac muscle cell apoptotic process|nuclear body|protein kinase binding|positive regulation of BMP signaling pathway|response to vitamin A|activating transcription factor binding|embryonic heart tube anterior/posterior pattern specification|wound healing|response to drug|sequence-specific DNA binding|cell fate commitment|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic foregut morphogenesis|NFAT protein binding|positive regulation of cardioblast differentiation|regulation of protein kinase B signaling|transdifferentiation|atrial septum morphogenesis|intestinal epithelial cell differentiation|cardiac muscle tissue regeneration|cell growth involved in cardiac muscle cell development|positive regulation of ERK1 and ERK2 cascade|co-SMAD binding|cellular response to glucose stimulus|regulation of cardiac muscle cell contraction|RNA polymerase II transcription regulator complex|negative regulation of oxidative stress-induced cell death|sequence-specific double-stranded DNA binding|negative regulation of apoptotic signaling pathway" "hsa04022,hsa04218,hsa04530,hsa04919" cGMP-PKG signaling pathway|Cellular senescence|Tight junction|Thyroid hormone signaling pathway zf-GATA GATA6 168.8674432 194.8715459 142.8633404 0.733115446 -0.447887692 0.433800255 1 2.72338751 2.082561048 2627 GATA binding protein 6 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001103,GO:0001701,GO:0001889,GO:0001949,GO:0002759,GO:0003148,GO:0003309,GO:0003310,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006644,GO:0007493,GO:0007596,GO:0008134,GO:0008270,GO:0008584,GO:0014898,GO:0019901,GO:0030855,GO:0031965,GO:0032526,GO:0032911,GO:0032912,GO:0035239,GO:0042493,GO:0043066,GO:0043627,GO:0044267,GO:0045165,GO:0045766,GO:0045892,GO:0045893,GO:0045944,GO:0048645,GO:0051145,GO:0051891,GO:0055007,GO:0060045,GO:0060430,GO:0060486,GO:0060510,GO:0060575,GO:0060947,GO:0070848,GO:0071158,GO:0071371,GO:0071456,GO:0071773,GO:0098773,GO:0110024,GO:1901390,GO:1904003,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|in utero embryonic development|liver development|sebaceous gland cell differentiation|regulation of antimicrobial humoral response|outflow tract septum morphogenesis|type B pancreatic cell differentiation|pancreatic A cell differentiation|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|phospholipid metabolic process|endodermal cell fate determination|blood coagulation|transcription factor binding|zinc ion binding|male gonad development|cardiac muscle hypertrophy in response to stress|protein kinase binding|epithelial cell differentiation|nuclear membrane|response to retinoic acid|negative regulation of transforming growth factor beta1 production|negative regulation of transforming growth factor beta2 production|tube morphogenesis|response to drug|negative regulation of apoptotic process|response to estrogen|cellular protein metabolic process|cell fate commitment|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|animal organ formation|smooth muscle cell differentiation|positive regulation of cardioblast differentiation|cardiac muscle cell differentiation|positive regulation of cardiac muscle cell proliferation|lung saccule development|club cell differentiation|type II pneumocyte differentiation|intestinal epithelial cell differentiation|cardiac vascular smooth muscle cell differentiation|response to growth factor|positive regulation of cell cycle arrest|cellular response to gonadotropin stimulus|cellular response to hypoxia|cellular response to BMP stimulus|skin epidermis development|positive regulation of cardiac muscle myoblast proliferation|positive regulation of transforming growth factor beta activation|negative regulation of sebum secreting cell proliferation|sequence-specific double-stranded DNA binding" zf-GATA GATAD1 736.5170724 709.4542219 763.5799228 1.076292027 0.106069574 0.779194424 1 13.19550258 14.81398802 57798 GATA zinc finger domain containing 1 "GO:0005634,GO:0005654,GO:0006325,GO:0006338,GO:0006355,GO:0008270,GO:0043565" "nucleus|nucleoplasm|chromatin organization|chromatin remodeling|regulation of transcription, DNA-templated|zinc ion binding|sequence-specific DNA binding" zf-GATA GATAD2A 1888.039297 1972.059447 1804.019147 0.914789435 -0.128488391 0.692239025 1 14.08913161 13.44377687 54815 GATA zinc finger domain containing 2A "GO:0000122,GO:0005515,GO:0005634,GO:0005654,GO:0006306,GO:0008270,GO:0016581,GO:0016607,GO:0030674,GO:0043565,GO:0045892" "negative regulation of transcription by RNA polymerase II|protein binding|nucleus|nucleoplasm|DNA methylation|zinc ion binding|NuRD complex|nuclear speck|protein-macromolecule adaptor activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated" GATAD2B 1192.721221 1115.436609 1270.005833 1.138572844 0.187226596 0.585372136 1 6.869276415 8.158075939 57459 GATA zinc finger domain containing 2B "GO:0000122,GO:0000785,GO:0005515,GO:0005654,GO:0008270,GO:0016581,GO:0016607,GO:0031492,GO:0032991,GO:0043044,GO:0043565" negative regulation of transcription by RNA polymerase II|chromatin|protein binding|nucleoplasm|zinc ion binding|NuRD complex|nuclear speck|nucleosomal DNA binding|protein-containing complex|ATP-dependent chromatin remodeling|sequence-specific DNA binding GATB 373.1301764 384.668312 361.5920409 0.94000995 -0.089252067 0.845437171 1 8.223762336 8.0634135 5188 glutamyl-tRNA amidotransferase subunit B "GO:0005515,GO:0005524,GO:0005739,GO:0030956,GO:0032543,GO:0050567,GO:0070681" protein binding|ATP binding|mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex|mitochondrial translation|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|glutaminyl-tRNAGln biosynthesis via transamidation hsa00970 Aminoacyl-tRNA biosynthesis GATC 1361.063619 1341.77179 1380.355448 1.028755752 0.040900498 0.90517284 1 16.03492395 17.2066019 283459 glutamyl-tRNA amidotransferase subunit C "GO:0005515,GO:0005524,GO:0005739,GO:0006450,GO:0030956,GO:0032543,GO:0050567,GO:0070681" protein binding|ATP binding|mitochondrion|regulation of translational fidelity|glutamyl-tRNA(Gln) amidotransferase complex|mitochondrial translation|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|glutaminyl-tRNAGln biosynthesis via transamidation hsa00970 Aminoacyl-tRNA biosynthesis GATD1 1137.311603 1065.703767 1208.919439 1.134386006 0.18191164 0.598929706 1 9.660665153 11.43098933 347862 glutamine amidotransferase like class 1 domain containing 1 "GO:0003674,GO:0008150,GO:0070062" molecular_function|biological_process|extracellular exosome GATD3A 245.3563258 237.4996966 253.2129551 1.066161173 0.092425548 0.861947938 1 5.550771474 6.172941196 8209 glutamine amidotransferase like class 1 domain containing 3A GO:0005739 mitochondrion GATD3B 228.5744176 268.9633316 188.1855036 0.699669737 -0.515254003 0.318822765 1 8.59977519 6.27619051 102724023 glutamine amidotransferase like class 1 domain containing 3B "GO:0005515,GO:0005739" protein binding|mitochondrion GATM 4.044978098 7.104691779 0.985264417 0.138677996 -2.850189203 0.227217187 1 0.121399317 0.017560615 2628 glycine amidinotransferase "GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0006600,GO:0006601,GO:0007275,GO:0007611,GO:0014889,GO:0015067,GO:0015068,GO:0070062,GO:0120162" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|creatine metabolic process|creatine biosynthetic process|multicellular organism development|learning or memory|muscle atrophy|amidinotransferase activity|glycine amidinotransferase activity|extracellular exosome|positive regulation of cold-induced thermogenesis "hsa00260,hsa00330" "Glycine, serine and threonine metabolism|Arginine and proline metabolism" GBA 2378.79228 2685.573492 2072.011068 0.771533929 -0.374198493 0.241626737 1 56.36751896 45.36280264 2629 glucosylceramidase beta "GO:0004348,GO:0005102,GO:0005124,GO:0005515,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005802,GO:0006680,GO:0006687,GO:0006914,GO:0007005,GO:0007040,GO:0008203,GO:0008340,GO:0009267,GO:0009268,GO:0014004,GO:0016241,GO:0019882,GO:0019898,GO:0019915,GO:0021694,GO:0021859,GO:0023021,GO:0030259,GO:0031175,GO:0031333,GO:0032006,GO:0032268,GO:0032436,GO:0032715,GO:0033077,GO:0033561,GO:0033574,GO:0035307,GO:0036473,GO:0043202,GO:0043243,GO:0043407,GO:0043524,GO:0043589,GO:0043627,GO:0046512,GO:0046513,GO:0046527,GO:0048469,GO:0048854,GO:0048872,GO:0050295,GO:0050728,GO:0050905,GO:0051247,GO:0051402,GO:0061518,GO:0061744,GO:0070062,GO:0071356,GO:0071425,GO:0071548,GO:0072676,GO:0097066,GO:1901215,GO:1901805,GO:1903052,GO:1903061,GO:1904457,GO:1904925,GO:1905037,GO:1905165" glucosylceramidase activity|signaling receptor binding|scavenger receptor binding|protein binding|lysosome|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|glucosylceramide catabolic process|glycosphingolipid metabolic process|autophagy|mitochondrion organization|lysosome organization|cholesterol metabolic process|determination of adult lifespan|cellular response to starvation|response to pH|microglia differentiation|regulation of macroautophagy|antigen processing and presentation|extrinsic component of membrane|lipid storage|cerebellar Purkinje cell layer formation|pyramidal neuron differentiation|termination of signal transduction|lipid glycosylation|neuron projection development|negative regulation of protein-containing complex assembly|regulation of TOR signaling|regulation of cellular protein metabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of interleukin-6 production|T cell differentiation in thymus|regulation of water loss via skin|response to testosterone|positive regulation of protein dephosphorylation|cell death in response to oxidative stress|lysosomal lumen|positive regulation of protein-containing complex disassembly|negative regulation of MAP kinase activity|negative regulation of neuron apoptotic process|skin morphogenesis|response to estrogen|sphingosine biosynthetic process|ceramide biosynthetic process|glucosyltransferase activity|cell maturation|brain morphogenesis|homeostasis of number of cells|steryl-beta-glucosidase activity|negative regulation of inflammatory response|neuromuscular process|positive regulation of protein metabolic process|neuron apoptotic process|microglial cell proliferation|motor behavior|extracellular exosome|cellular response to tumor necrosis factor|hematopoietic stem cell proliferation|response to dexamethasone|lymphocyte migration|response to thyroid hormone|negative regulation of neuron death|beta-glucoside catabolic process|positive regulation of proteolysis involved in cellular protein catabolic process|positive regulation of protein lipidation|positive regulation of neuronal action potential|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|autophagosome organization|regulation of lysosomal protein catabolic process "hsa00511,hsa00600,hsa04142" Other glycan degradation|Sphingolipid metabolism|Lysosome GBA2 1665.564263 1412.818708 1918.309819 1.357789084 0.441259392 0.178162346 1 20.52618572 29.07076742 57704 glucosylceramidase beta 2 "GO:0004348,GO:0005790,GO:0005829,GO:0005886,GO:0005975,GO:0006680,GO:0006687,GO:0007417,GO:0008203,GO:0008206,GO:0008422,GO:0016021,GO:0016139,GO:0019898,GO:0021954,GO:0030259,GO:0030833,GO:0031113,GO:0042406,GO:0046527,GO:0050295,GO:0090498,GO:0097035" glucosylceramidase activity|smooth endoplasmic reticulum|cytosol|plasma membrane|carbohydrate metabolic process|glucosylceramide catabolic process|glycosphingolipid metabolic process|central nervous system development|cholesterol metabolic process|bile acid metabolic process|beta-glucosidase activity|integral component of membrane|glycoside catabolic process|extrinsic component of membrane|central nervous system neuron development|lipid glycosylation|regulation of actin filament polymerization|regulation of microtubule polymerization|extrinsic component of endoplasmic reticulum membrane|glucosyltransferase activity|steryl-beta-glucosidase activity|extrinsic component of Golgi membrane|regulation of membrane lipid distribution "hsa00511,hsa00600" Other glycan degradation|Sphingolipid metabolism GBE1 1636.313887 1669.602568 1603.025206 0.960123826 -0.058707614 0.859637339 1 28.75194834 28.79456064 2632 "1,4-alpha-glucan branching enzyme 1" "GO:0003844,GO:0004553,GO:0005515,GO:0005737,GO:0005829,GO:0005975,GO:0005977,GO:0005978,GO:0006091,GO:0030246,GO:0043169,GO:0043524,GO:0070062,GO:0102752" "1,4-alpha-glucan branching enzyme activity|hydrolase activity, hydrolyzing O-glycosyl compounds|protein binding|cytoplasm|cytosol|carbohydrate metabolic process|glycogen metabolic process|glycogen biosynthetic process|generation of precursor metabolites and energy|carbohydrate binding|cation binding|negative regulation of neuron apoptotic process|extracellular exosome|1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)" hsa00500 Starch and sucrose metabolism GBF1 6649.883849 6725.098246 6574.669452 0.977631733 -0.032636981 0.920786524 1 50.23635715 51.22823096 8729 golgi brefeldin A resistant guanine nucleotide exchange factor 1 "GO:0000139,GO:0002263,GO:0005085,GO:0005515,GO:0005547,GO:0005793,GO:0005794,GO:0005801,GO:0005802,GO:0005811,GO:0005829,GO:0006888,GO:0006890,GO:0006892,GO:0006895,GO:0007030,GO:0007346,GO:0015031,GO:0016020,GO:0016032,GO:0030593,GO:0031252,GO:0032012,GO:0034067,GO:0042147,GO:0048205,GO:0050790,GO:0061162,GO:0070973,GO:0080025,GO:0090166,GO:0097111,GO:0098586,GO:1903409,GO:1903420,GO:2000008" "Golgi membrane|cell activation involved in immune response|guanyl-nucleotide exchange factor activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|trans-Golgi network|lipid droplet|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|post-Golgi vesicle-mediated transport|Golgi to endosome transport|Golgi organization|regulation of mitotic cell cycle|protein transport|membrane|viral process|neutrophil chemotaxis|cell leading edge|regulation of ARF protein signal transduction|protein localization to Golgi apparatus|retrograde transport, endosome to Golgi|COPI coating of Golgi vesicle|regulation of catalytic activity|establishment of monopolar cell polarity|protein localization to endoplasmic reticulum exit site|phosphatidylinositol-3,5-bisphosphate binding|Golgi disassembly|endoplasmic reticulum-Golgi intermediate compartment organization|cellular response to virus|reactive oxygen species biosynthetic process|protein localization to endoplasmic reticulum tubular network|regulation of protein localization to cell surface" hsa04144 Endocytosis GBGT1 184.6047039 159.348087 209.8613207 1.31699931 0.39725459 0.475293769 1 4.053449755 5.568346745 26301 "globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)" "GO:0000139,GO:0005794,GO:0005975,GO:0006486,GO:0009247,GO:0016021,GO:0016757,GO:0030259,GO:0031982,GO:0046872,GO:0047277" "Golgi membrane|Golgi apparatus|carbohydrate metabolic process|protein glycosylation|glycolipid biosynthetic process|integral component of membrane|transferase activity, transferring glycosyl groups|lipid glycosylation|vesicle|metal ion binding|globoside alpha-N-acetylgalactosaminyltransferase activity" hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series GBP1 250.9655536 284.1876711 217.7434361 0.766195927 -0.384214739 0.444490331 1 5.051984201 4.037548501 2633 guanylate binding protein 1 "GO:0000139,GO:0003779,GO:0003924,GO:0005515,GO:0005525,GO:0005576,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0012506,GO:0015629,GO:0019003,GO:0019899,GO:0019955,GO:0030507,GO:0031410,GO:0032703,GO:0042802,GO:0042803,GO:0050848,GO:0050860,GO:0051607,GO:0051879,GO:0060333,GO:0070373,GO:0071346,GO:0071347,GO:0071356,GO:0072665,GO:1900025,GO:1903076,GO:1903077" Golgi membrane|actin binding|GTPase activity|protein binding|GTP binding|extracellular region|cytoplasm|Golgi apparatus|cytosol|plasma membrane|vesicle membrane|actin cytoskeleton|GDP binding|enzyme binding|cytokine binding|spectrin binding|cytoplasmic vesicle|negative regulation of interleukin-2 production|identical protein binding|protein homodimerization activity|regulation of calcium-mediated signaling|negative regulation of T cell receptor signaling pathway|defense response to virus|Hsp90 protein binding|interferon-gamma-mediated signaling pathway|negative regulation of ERK1 and ERK2 cascade|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor|protein localization to vacuole|negative regulation of substrate adhesion-dependent cell spreading|regulation of protein localization to plasma membrane|negative regulation of protein localization to plasma membrane hsa04621 NOD-like receptor signaling pathway GBP2 284.930206 248.6642123 321.1961998 1.291686475 0.369255934 0.443925348 1 3.080715537 4.150731499 2634 guanylate binding protein 2 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006955,GO:0031410,GO:0034504,GO:0042803,GO:0042832,GO:0048471,GO:0050830,GO:0060333,GO:0060337,GO:0071346,GO:0071347,GO:0071356" Golgi membrane|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|immune response|cytoplasmic vesicle|protein localization to nucleus|protein homodimerization activity|defense response to protozoan|perinuclear region of cytoplasm|defense response to Gram-positive bacterium|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor hsa04621 NOD-like receptor signaling pathway GBP3 585.2144042 401.9225635 768.5062449 1.912075396 0.935139412 0.018010131 0.579832117 6.038552341 12.04352942 2635 guanylate binding protein 3 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005829,GO:0031410,GO:0042803,GO:0048471,GO:0051607,GO:0071346,GO:0071347,GO:0071356" Golgi membrane|GTPase activity|protein binding|GTP binding|cytoplasm|cytosol|cytoplasmic vesicle|protein homodimerization activity|perinuclear region of cytoplasm|defense response to virus|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor hsa04621 NOD-like receptor signaling pathway GBP4 19.58380052 25.37389921 13.79370183 0.543617743 -0.879335549 0.443480744 1 0.209265345 0.118660689 115361 guanylate binding protein 4 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005794,GO:0005829,GO:0005886,GO:0031410,GO:0042803,GO:0042832,GO:0048471,GO:0050830,GO:0071346" Golgi membrane|GTPase activity|protein binding|GTP binding|nucleus|Golgi apparatus|cytosol|plasma membrane|cytoplasmic vesicle|protein homodimerization activity|defense response to protozoan|perinuclear region of cytoplasm|defense response to Gram-positive bacterium|cellular response to interferon-gamma hsa04621 NOD-like receptor signaling pathway GBP5 18.68761076 31.46363502 5.911586499 0.187886317 -2.412068091 0.043987323 0.952191822 0.233928672 0.04584527 115362 guanylate binding protein 5 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0006954,GO:0016020,GO:0031410,GO:0032611,GO:0032621,GO:0034067,GO:0042802,GO:0042803,GO:0045089,GO:0048471,GO:0051289,GO:0071346,GO:1900017,GO:1900227" Golgi membrane|GTPase activity|protein binding|GTP binding|cytoplasm|Golgi apparatus|inflammatory response|membrane|cytoplasmic vesicle|interleukin-1 beta production|interleukin-18 production|protein localization to Golgi apparatus|identical protein binding|protein homodimerization activity|positive regulation of innate immune response|perinuclear region of cytoplasm|protein homotetramerization|cellular response to interferon-gamma|positive regulation of cytokine production involved in inflammatory response|positive regulation of NLRP3 inflammasome complex assembly hsa04621 NOD-like receptor signaling pathway GBX2 20.97262249 19.2841634 22.66108158 1.175113543 0.232800161 0.872211877 1 0.44863337 0.549904578 2637 gastrulation brain homeobox 2 "GO:0000785,GO:0000977,GO:0000979,GO:0000981,GO:0001085,GO:0001228,GO:0001569,GO:0001755,GO:0003700,GO:0005634,GO:0006357,GO:0007399,GO:0007411,GO:0021549,GO:0021555,GO:0021568,GO:0021794,GO:0021884,GO:0021930,GO:0042472,GO:0045944,GO:0048483,GO:0051960,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|branching involved in blood vessel morphogenesis|neural crest cell migration|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|nervous system development|axon guidance|cerebellum development|midbrain-hindbrain boundary morphogenesis|rhombomere 2 development|thalamus development|forebrain neuron development|cerebellar granule cell precursor proliferation|inner ear morphogenesis|positive regulation of transcription by RNA polymerase II|autonomic nervous system development|regulation of nervous system development|sequence-specific double-stranded DNA binding" GCA 153.2719592 139.0489677 167.4949508 1.204575292 0.268524572 0.653960588 1 1.40201865 1.761585274 25801 grancalcin "GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0005886,GO:0035578,GO:0042803,GO:0043312,GO:0046982,GO:0061025,GO:0070062" calcium ion binding|protein binding|extracellular region|cytoplasm|cytosol|plasma membrane|azurophil granule lumen|protein homodimerization activity|neutrophil degranulation|protein heterodimerization activity|membrane fusion|extracellular exosome GCAT 98.63704305 108.6002886 88.67379749 0.816515302 -0.292448171 0.676003131 1 2.659681576 2.265217473 23464 glycine C-acetyltransferase "GO:0005654,GO:0005739,GO:0005743,GO:0006520,GO:0008890,GO:0009058,GO:0016607,GO:0019518,GO:0030170" nucleoplasm|mitochondrion|mitochondrial inner membrane|cellular amino acid metabolic process|glycine C-acetyltransferase activity|biosynthetic process|nuclear speck|L-threonine catabolic process to glycine|pyridoxal phosphate binding hsa00260 "Glycine, serine and threonine metabolism" GCC1 448.0048289 451.6554059 444.3542519 0.98383468 -0.023512184 0.961150247 1 5.541364575 5.686627503 79571 GRIP and coiled-coil domain containing 1 "GO:0000138,GO:0000139,GO:0005515,GO:0005794,GO:0005829,GO:0031267" Golgi trans cisterna|Golgi membrane|protein binding|Golgi apparatus|cytosol|small GTPase binding GCC2 818.3412779 679.0055428 957.6770129 1.410411186 0.496115822 0.175146549 1 4.199955466 6.178831598 9648 GRIP and coiled-coil domain containing 2 "GO:0005515,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0006622,GO:0016020,GO:0031023,GO:0031267,GO:0034067,GO:0034453,GO:0034499,GO:0042147,GO:0042802,GO:0043001,GO:0070861,GO:0071955,GO:0090161" "protein binding|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|protein targeting to lysosome|membrane|microtubule organizing center organization|small GTPase binding|protein localization to Golgi apparatus|microtubule anchoring|late endosome to Golgi transport|retrograde transport, endosome to Golgi|identical protein binding|Golgi to plasma membrane protein transport|regulation of protein exit from endoplasmic reticulum|recycling endosome to Golgi transport|Golgi ribbon formation" hsa05132 Salmonella infection GCDH 222.1283832 232.4249168 211.8318496 0.911399055 -0.13384522 0.804151208 1 6.356102639 6.042482558 2639 glutaryl-CoA dehydrogenase "GO:0000062,GO:0004361,GO:0005739,GO:0005759,GO:0006554,GO:0006568,GO:0033539,GO:0046949,GO:0050660" fatty-acyl-CoA binding|glutaryl-CoA dehydrogenase activity|mitochondrion|mitochondrial matrix|lysine catabolic process|tryptophan metabolic process|fatty acid beta-oxidation using acyl-CoA dehydrogenase|fatty-acyl-CoA biosynthetic process|flavin adenine dinucleotide binding "hsa00071,hsa00310,hsa00380" Fatty acid degradation|Lysine degradation|Tryptophan metabolism GCFC2 189.3474334 214.1557093 164.5391576 0.768315531 -0.380229177 0.490934456 1 1.030814596 0.826106618 6936 GC-rich sequence DNA-binding factor 2 "GO:0000245,GO:0000398,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006355,GO:0045892,GO:0071008" "spliceosomal complex assembly|mRNA splicing, via spliceosome|DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|U2-type post-mRNA release spliceosomal complex" GCH1 163.7508476 148.1835714 179.3181238 1.210107991 0.2751358 0.637984633 1 1.947826403 2.458613754 2643 GTP cyclohydrolase 1 "GO:0003924,GO:0003934,GO:0005509,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006729,GO:0006809,GO:0008217,GO:0008270,GO:0010460,GO:0014916,GO:0030742,GO:0031369,GO:0031410,GO:0031965,GO:0032496,GO:0032991,GO:0034341,GO:0034612,GO:0035998,GO:0042311,GO:0042416,GO:0042559,GO:0042802,GO:0042803,GO:0044306,GO:0044877,GO:0045776,GO:0046654,GO:0048265,GO:0050884,GO:0051000,GO:0051019,GO:0065003,GO:2000121" "GTPase activity|GTP cyclohydrolase I activity|calcium ion binding|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|tetrahydrobiopterin biosynthetic process|nitric oxide biosynthetic process|regulation of blood pressure|zinc ion binding|positive regulation of heart rate|regulation of lung blood pressure|GTP-dependent protein binding|translation initiation factor binding|cytoplasmic vesicle|nuclear membrane|response to lipopolysaccharide|protein-containing complex|response to interferon-gamma|response to tumor necrosis factor|7,8-dihydroneopterin 3'-triphosphate biosynthetic process|vasodilation|dopamine biosynthetic process|pteridine-containing compound biosynthetic process|identical protein binding|protein homodimerization activity|neuron projection terminus|protein-containing complex binding|negative regulation of blood pressure|tetrahydrofolate biosynthetic process|response to pain|neuromuscular process controlling posture|positive regulation of nitric-oxide synthase activity|mitogen-activated protein kinase binding|protein-containing complex assembly|regulation of removal of superoxide radicals" hsa00790 Folate biosynthesis GCHFR 393.7559029 447.5955821 339.9162237 0.75942712 -0.397016575 0.36272636 1 31.18175682 24.70032184 2644 GTP cyclohydrolase I feedback regulator "GO:0004857,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006809,GO:0009890,GO:0016597,GO:0030425,GO:0030742,GO:0031965,GO:0032991,GO:0042133,GO:0042470,GO:0043105,GO:0044549,GO:0044877,GO:0065003" enzyme inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|nitric oxide biosynthetic process|negative regulation of biosynthetic process|amino acid binding|dendrite|GTP-dependent protein binding|nuclear membrane|protein-containing complex|neurotransmitter metabolic process|melanosome|negative regulation of GTP cyclohydrolase I activity|GTP cyclohydrolase binding|protein-containing complex binding|protein-containing complex assembly GCKR 8.552896852 12.17947162 4.926322083 0.404477488 -1.305868687 0.399342453 1 0.275870873 0.116390125 2646 glucokinase regulator "GO:0004857,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005975,GO:0006110,GO:0006606,GO:0009750,GO:0019899,GO:0030246,GO:0033132,GO:0042593,GO:0046415,GO:0070095,GO:0070328,GO:1901135" enzyme inhibitor activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|carbohydrate metabolic process|regulation of glycolytic process|protein import into nucleus|response to fructose|enzyme binding|carbohydrate binding|negative regulation of glucokinase activity|glucose homeostasis|urate metabolic process|fructose-6-phosphate binding|triglyceride homeostasis|carbohydrate derivative metabolic process GCLC 344.1418266 356.2495449 332.0341084 0.932026758 -0.10155672 0.828115331 1 5.248046154 5.102017647 2729 glutamate-cysteine ligase catalytic subunit "GO:0000287,GO:0004357,GO:0005515,GO:0005524,GO:0005829,GO:0006534,GO:0006536,GO:0006750,GO:0006979,GO:0009408,GO:0009725,GO:0016595,GO:0017109,GO:0043066,GO:0043531,GO:0045454,GO:0045892,GO:0097746" "magnesium ion binding|glutamate-cysteine ligase activity|protein binding|ATP binding|cytosol|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|response to oxidative stress|response to heat|response to hormone|glutamate binding|glutamate-cysteine ligase complex|negative regulation of apoptotic process|ADP binding|cell redox homeostasis|negative regulation of transcription, DNA-templated|blood vessel diameter maintenance" "hsa00270,hsa00480,hsa04216" Cysteine and methionine metabolism|Glutathione metabolism|Ferroptosis GCLM 970.4807527 976.3876416 964.5738638 0.987900525 -0.017562315 0.963612924 1 7.750876106 7.986931155 2730 glutamate-cysteine ligase modifier subunit "GO:0004357,GO:0005515,GO:0005829,GO:0006534,GO:0006536,GO:0006750,GO:0006979,GO:0007568,GO:0007584,GO:0008637,GO:0014823,GO:0017109,GO:0030234,GO:0035226,GO:0035229,GO:0035729,GO:0035733,GO:0042493,GO:0043524,GO:0044344,GO:0044752,GO:0044877,GO:0051409,GO:0051900,GO:0071333,GO:0071372,GO:0097069,GO:0097746,GO:1990830,GO:2001237" glutamate-cysteine ligase activity|protein binding|cytosol|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|response to oxidative stress|aging|response to nutrient|apoptotic mitochondrial changes|response to activity|glutamate-cysteine ligase complex|enzyme regulator activity|glutamate-cysteine ligase catalytic subunit binding|positive regulation of glutamate-cysteine ligase activity|cellular response to hepatocyte growth factor stimulus|hepatic stellate cell activation|response to drug|negative regulation of neuron apoptotic process|cellular response to fibroblast growth factor stimulus|response to human chorionic gonadotropin|protein-containing complex binding|response to nitrosative stress|regulation of mitochondrial depolarization|cellular response to glucose stimulus|cellular response to follicle-stimulating hormone stimulus|cellular response to thyroxine stimulus|blood vessel diameter maintenance|cellular response to leukemia inhibitory factor|negative regulation of extrinsic apoptotic signaling pathway "hsa00270,hsa00480,hsa04216" Cysteine and methionine metabolism|Glutathione metabolism|Ferroptosis GCN1 4529.965962 4729.694813 4330.237111 0.915542605 -0.127301071 0.690891106 1 27.59386671 26.35160373 10985 GCN1 activator of EIF2AK4 "GO:0003723,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006417,GO:0008135,GO:0016020,GO:0019887,GO:0019901,GO:0033674,GO:0034198,GO:0036003,GO:0043022,GO:0045296,GO:0045859,GO:1990253" "RNA binding|cytoplasm|cytosol|ribosome|polysome|translation|regulation of translation|translation factor activity, RNA binding|membrane|protein kinase regulator activity|protein kinase binding|positive regulation of kinase activity|cellular response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to stress|ribosome binding|cadherin binding|regulation of protein kinase activity|cellular response to leucine starvation" GCNA 14.59809533 21.31407534 7.882115332 0.369807989 -1.435151704 0.250679294 1 0.251042494 0.096836584 93953 germ cell nuclear acidic peptidase "GO:0005634,GO:0005654" nucleus|nucleoplasm GCNT2 268.8487709 294.3372308 243.3603109 0.826807775 -0.27437614 0.5782991 1 1.463780674 1.26239856 2651 glucosaminyl (N-acetyl) transferase 2 (I blood group) "GO:0000139,GO:0005794,GO:0006024,GO:0006486,GO:0007179,GO:0007275,GO:0008109,GO:0008284,GO:0010608,GO:0010718,GO:0010812,GO:0016020,GO:0016021,GO:0030335,GO:0034116,GO:0036438,GO:0051897,GO:0070374" "Golgi membrane|Golgi apparatus|glycosaminoglycan biosynthetic process|protein glycosylation|transforming growth factor beta receptor signaling pathway|multicellular organism development|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity|positive regulation of cell population proliferation|posttranscriptional regulation of gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of cell-substrate adhesion|membrane|integral component of membrane|positive regulation of cell migration|positive regulation of heterotypic cell-cell adhesion|maintenance of lens transparency|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series GCNT4 32.30316328 19.2841634 45.32216316 2.350227087 1.232800161 0.205631817 1 0.194440543 0.476664251 51301 glucosaminyl (N-acetyl) transferase 4 "GO:0000139,GO:0002121,GO:0003829,GO:0005975,GO:0006493,GO:0008109,GO:0016021,GO:0016266,GO:0018215,GO:0042403,GO:0048729,GO:0048872,GO:0060993" "Golgi membrane|inter-male aggressive behavior|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|carbohydrate metabolic process|protein O-linked glycosylation|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|thyroid hormone metabolic process|tissue morphogenesis|homeostasis of number of cells|kidney morphogenesis" hsa00512 Mucin type O-glycan biosynthesis GCSH 263.159871 309.5615704 216.7581716 0.700210208 -0.51414 0.297588039 1 9.393769605 6.860950279 2653 glycine cleavage system protein H "GO:0004047,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005960,GO:0006546,GO:0009249,GO:0019464" aminomethyltransferase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|glycine cleavage complex|glycine catabolic process|protein lipoylation|glycine decarboxylation via glycine cleavage system "hsa00260,hsa00630" "Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism" GDA 43.70521135 57.8524902 29.5579325 0.510918932 -0.9688337 0.275285877 1 0.545526818 0.290726105 9615 guanine deaminase "GO:0005622,GO:0005829,GO:0006139,GO:0006147,GO:0006195,GO:0007399,GO:0008270,GO:0008892,GO:0019239,GO:0046098" intracellular anatomical structure|cytosol|nucleobase-containing compound metabolic process|guanine catabolic process|purine nucleotide catabolic process|nervous system development|zinc ion binding|guanine deaminase activity|deaminase activity|guanine metabolic process hsa00230 Purine metabolism GDAP1 455.3388883 582.5847258 328.0930507 0.563167959 -0.828362841 0.048450954 1 6.543770488 3.84398714 54332 ganglioside induced differentiation associated protein 1 "GO:0000266,GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0006626,GO:0006749,GO:0008053,GO:0016020,GO:0031307" mitochondrial fission|protein binding|nucleus|mitochondrion|cytosol|protein targeting to mitochondrion|glutathione metabolic process|mitochondrial fusion|membrane|integral component of mitochondrial outer membrane GDAP2 438.6475385 418.161859 459.1332181 1.097979666 0.134851336 0.753539459 1 2.093557035 2.397700997 54834 ganglioside induced differentiation associated protein 2 "GO:0005515,GO:0005765,GO:0032526" protein binding|lysosomal membrane|response to retinoic acid GDE1 1245.57712 1361.055954 1130.098286 0.830309939 -0.268278127 0.430572509 1 23.71265309 20.53696741 51573 glycerophosphodiester phosphodiesterase 1 "GO:0004622,GO:0005515,GO:0005886,GO:0006580,GO:0006629,GO:0006644,GO:0008889,GO:0016021,GO:0030659,GO:0046475,GO:0046872,GO:0047395,GO:0070291" lysophospholipase activity|protein binding|plasma membrane|ethanolamine metabolic process|lipid metabolic process|phospholipid metabolic process|glycerophosphodiester phosphodiesterase activity|integral component of membrane|cytoplasmic vesicle membrane|glycerophospholipid catabolic process|metal ion binding|glycerophosphoinositol glycerophosphodiesterase activity|N-acylethanolamine metabolic process GDF11 463.0901132 539.9565752 386.2236513 0.715286505 -0.483406873 0.24622298 1 17.07047171 12.7362473 10220 growth differentiation factor 11 "GO:0001501,GO:0001656,GO:0001657,GO:0005125,GO:0005515,GO:0005615,GO:0005654,GO:0007399,GO:0007498,GO:0008083,GO:0008285,GO:0010862,GO:0021512,GO:0031016,GO:0032991,GO:0043231,GO:0045665,GO:0048469,GO:0048593,GO:0060021,GO:0060395" skeletal system development|metanephros development|ureteric bud development|cytokine activity|protein binding|extracellular space|nucleoplasm|nervous system development|mesoderm development|growth factor activity|negative regulation of cell population proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|spinal cord anterior/posterior patterning|pancreas development|protein-containing complex|intracellular membrane-bounded organelle|negative regulation of neuron differentiation|cell maturation|camera-type eye morphogenesis|roof of mouth development|SMAD protein signal transduction hsa04060 Cytokine-cytokine receptor interaction GDF15 702.7775821 1097.167402 308.3877624 0.281076308 -1.830966242 2.52E-06 0.000897622 32.32557203 9.477338418 9518 growth differentiation factor 15 "GO:0000187,GO:0002023,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005794,GO:0007165,GO:0007179,GO:0007267,GO:0008083,GO:0010862,GO:0030509,GO:0035860,GO:0040015,GO:0042803,GO:0043410,GO:0051897,GO:0060395,GO:0060400,GO:0062023,GO:0070062,GO:0070700,GO:1901741" activation of MAPK activity|reduction of food intake in response to dietary excess|cytokine activity|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|Golgi apparatus|signal transduction|transforming growth factor beta receptor signaling pathway|cell-cell signaling|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|BMP signaling pathway|glial cell-derived neurotrophic factor receptor signaling pathway|negative regulation of multicellular organism growth|protein homodimerization activity|positive regulation of MAPK cascade|positive regulation of protein kinase B signaling|SMAD protein signal transduction|negative regulation of growth hormone receptor signaling pathway|collagen-containing extracellular matrix|extracellular exosome|BMP receptor binding|positive regulation of myoblast fusion hsa04060 Cytokine-cytokine receptor interaction GDF5 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.097577713 0.079042769 8200 growth differentiation factor 5 "GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007179,GO:0007267,GO:0008083,GO:0009612,GO:0010862,GO:0030326,GO:0030509,GO:0030513,GO:0032331,GO:0032332,GO:0035136,GO:0035137,GO:0036122,GO:0040014,GO:0042802,GO:0043524,GO:0043932,GO:0045666,GO:0050680,GO:0060390,GO:0060395,GO:0060591,GO:2001054" cytokine activity|protein binding|extracellular region|extracellular space|plasma membrane|transforming growth factor beta receptor signaling pathway|cell-cell signaling|growth factor activity|response to mechanical stimulus|positive regulation of pathway-restricted SMAD protein phosphorylation|embryonic limb morphogenesis|BMP signaling pathway|positive regulation of BMP signaling pathway|negative regulation of chondrocyte differentiation|positive regulation of chondrocyte differentiation|forelimb morphogenesis|hindlimb morphogenesis|BMP binding|regulation of multicellular organism growth|identical protein binding|negative regulation of neuron apoptotic process|ossification involved in bone remodeling|positive regulation of neuron differentiation|negative regulation of epithelial cell proliferation|regulation of SMAD protein signal transduction|SMAD protein signal transduction|chondroblast differentiation|negative regulation of mesenchymal cell apoptotic process "hsa04060,hsa04350,hsa04390" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway GDF7 9.926873045 5.074779842 14.77896625 2.912237912 1.542128219 0.287072588 1 0.027734941 0.084250022 151449 growth differentiation factor 7 "GO:0005125,GO:0005515,GO:0005615,GO:0007411,GO:0008083,GO:0010862,GO:0021509,GO:0021527,GO:0022612,GO:0030509,GO:0030855,GO:0030901,GO:0032924,GO:0042802,GO:0045165,GO:0045666,GO:0045893,GO:0048608,GO:0048754,GO:0048853,GO:0060389,GO:0060395,GO:0060571,GO:2001051" "cytokine activity|protein binding|extracellular space|axon guidance|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|roof plate formation|spinal cord association neuron differentiation|gland morphogenesis|BMP signaling pathway|epithelial cell differentiation|midbrain development|activin receptor signaling pathway|identical protein binding|cell fate commitment|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|reproductive structure development|branching morphogenesis of an epithelial tube|forebrain morphogenesis|pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|morphogenesis of an epithelial fold|positive regulation of tendon cell differentiation" "hsa04060,hsa04350,hsa04360,hsa04390" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Axon guidance|Hippo signaling pathway GDF9 13.09050716 19.2841634 6.896850916 0.357643252 -1.483406873 0.25330742 1 0.496025823 0.185041974 2661 growth differentiation factor 9 "GO:0001555,GO:0005125,GO:0005615,GO:0005737,GO:0007179,GO:0007292,GO:0008083,GO:0008284,GO:0010862,GO:0030308,GO:0030509,GO:0060395,GO:0070698,GO:2000870" oocyte growth|cytokine activity|extracellular space|cytoplasm|transforming growth factor beta receptor signaling pathway|female gamete generation|growth factor activity|positive regulation of cell population proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of cell growth|BMP signaling pathway|SMAD protein signal transduction|type I activin receptor binding|regulation of progesterone secretion hsa04060 Cytokine-cytokine receptor interaction GDI1 5730.2271 4912.386887 6548.067312 1.332970603 0.414644964 0.200307787 1 111.0692259 154.4294933 2664 GDP dissociation inhibitor 1 "GO:0005092,GO:0005093,GO:0005096,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0007165,GO:0015031,GO:0016192,GO:0030424,GO:0030496,GO:0032482,GO:0032991,GO:0043025,GO:0043209,GO:0043547,GO:0045773,GO:0050771,GO:0051056,GO:0051592,GO:0090315" GDP-dissociation inhibitor activity|Rab GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|cytoplasm|Golgi apparatus|cytosol|signal transduction|protein transport|vesicle-mediated transport|axon|midbody|Rab protein signal transduction|protein-containing complex|neuronal cell body|myelin sheath|positive regulation of GTPase activity|positive regulation of axon extension|negative regulation of axonogenesis|regulation of small GTPase mediated signal transduction|response to calcium ion|negative regulation of protein targeting to membrane GDI2 6991.839141 7167.619049 6816.059234 0.95095166 -0.072556089 0.82495526 1 86.94960933 86.24660444 2665 GDP dissociation inhibitor 2 "GO:0003723,GO:0005093,GO:0005096,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0005925,GO:0007165,GO:0007264,GO:0015031,GO:0016020,GO:0016192,GO:0031982,GO:0034774,GO:0035578,GO:0043312,GO:0043547,GO:0045202,GO:0051056,GO:0070062" RNA binding|Rab GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|extracellular region|cytoplasm|cytosol|focal adhesion|signal transduction|small GTPase mediated signal transduction|protein transport|membrane|vesicle-mediated transport|vesicle|secretory granule lumen|azurophil granule lumen|neutrophil degranulation|positive regulation of GTPase activity|synapse|regulation of small GTPase mediated signal transduction|extracellular exosome GDPD1 103.8926938 97.43577296 110.3496147 1.132536966 0.17955814 0.799918836 1 1.80101393 2.127577495 284161 glycerophosphodiester phosphodiesterase domain containing 1 "GO:0004622,GO:0005783,GO:0005789,GO:0008081,GO:0016020,GO:0016021,GO:0046475,GO:0046872,GO:0048471,GO:0070291" lysophospholipase activity|endoplasmic reticulum|endoplasmic reticulum membrane|phosphoric diester hydrolase activity|membrane|integral component of membrane|glycerophospholipid catabolic process|metal ion binding|perinuclear region of cytoplasm|N-acylethanolamine metabolic process hsa00565 Ether lipid metabolism GDPD3 13.97185114 12.17947162 15.76423066 1.294327961 0.372203218 0.812338614 1 0.572214537 0.772536753 79153 glycerophosphodiester phosphodiesterase domain containing 3 "GO:0004622,GO:0005783,GO:0005789,GO:0008081,GO:0016021,GO:0034638,GO:0046475,GO:0046872,GO:0048471,GO:0070062,GO:0070291" lysophospholipase activity|endoplasmic reticulum|endoplasmic reticulum membrane|phosphoric diester hydrolase activity|integral component of membrane|phosphatidylcholine catabolic process|glycerophospholipid catabolic process|metal ion binding|perinuclear region of cytoplasm|extracellular exosome|N-acylethanolamine metabolic process hsa00565 Ether lipid metabolism GDPD5 824.2001622 776.4413158 871.9590086 1.123019848 0.167383426 0.648360484 1 7.028420648 8.233056726 81544 glycerophosphodiester phosphodiesterase domain containing 5 "GO:0004435,GO:0005515,GO:0006629,GO:0007399,GO:0012505,GO:0016021,GO:0030426,GO:0047389,GO:0048471" phosphatidylinositol phospholipase C activity|protein binding|lipid metabolic process|nervous system development|endomembrane system|integral component of membrane|growth cone|glycerophosphocholine phosphodiesterase activity|perinuclear region of cytoplasm GDPGP1 82.59074265 89.31612522 75.86536007 0.849402724 -0.235479359 0.756230135 1 0.862120574 0.763831543 390637 GDP-D-glucose phosphorylase 1 "GO:0000166,GO:0005085,GO:0005737,GO:0006006,GO:0016779,GO:0016787,GO:0050790,GO:0080048" nucleotide binding|guanyl-nucleotide exchange factor activity|cytoplasm|glucose metabolic process|nucleotidyltransferase activity|hydrolase activity|regulation of catalytic activity|GDP-D-glucose phosphorylase activity GEM 246.7545504 299.4120107 194.0970901 0.648260868 -0.625353606 0.214515202 1 6.401081502 4.328317328 2669 GTP binding protein overexpressed in skeletal muscle "GO:0000278,GO:0000287,GO:0003924,GO:0005246,GO:0005515,GO:0005516,GO:0005525,GO:0005634,GO:0005886,GO:0006955,GO:0007165,GO:0007166,GO:0009898,GO:0019003,GO:0030496,GO:0051233,GO:0051276,GO:0051310,GO:0072686,GO:1901842" mitotic cell cycle|magnesium ion binding|GTPase activity|calcium channel regulator activity|protein binding|calmodulin binding|GTP binding|nucleus|plasma membrane|immune response|signal transduction|cell surface receptor signaling pathway|cytoplasmic side of plasma membrane|GDP binding|midbody|spindle midzone|chromosome organization|metaphase plate congression|mitotic spindle|negative regulation of high voltage-gated calcium channel activity GEMIN2 199.484869 199.9463258 199.0234121 0.995384193 -0.006674618 1 1 7.327479039 7.607837966 8487 gem nuclear organelle associated protein 2 "GO:0000245,GO:0000375,GO:0000387,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005829,GO:0006397,GO:0008380,GO:0016604,GO:0032797,GO:0034719,GO:0051170,GO:0097504" "spliceosomal complex assembly|RNA splicing, via transesterification reactions|spliceosomal snRNP assembly|protein binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|cytosol|mRNA processing|RNA splicing|nuclear body|SMN complex|SMN-Sm protein complex|import into nucleus|Gemini of coiled bodies" hsa03013 RNA transport GEMIN4 1046.032868 1157.049804 935.0159313 0.808103444 -0.307388113 0.37965504 1 9.395621411 7.919693901 50628 gem nuclear organelle associated protein 4 "GO:0000387,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0015030,GO:0016020,GO:0016604,GO:0030532,GO:0032797,GO:0034719,GO:0043021,GO:0051170,GO:0070062,GO:0097504" spliceosomal snRNP assembly|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|Cajal body|membrane|nuclear body|small nuclear ribonucleoprotein complex|SMN complex|SMN-Sm protein complex|ribonucleoprotein complex binding|import into nucleus|extracellular exosome|Gemini of coiled bodies hsa03013 RNA transport GEMIN5 878.8660077 977.4025975 780.3294179 0.798370518 -0.324869649 0.368084961 1 9.160250462 7.628300084 25929 gem nuclear organelle associated protein 5 "GO:0000340,GO:0000387,GO:0000398,GO:0003723,GO:0003730,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006412,GO:0006417,GO:0016020,GO:0016604,GO:0017069,GO:0030619,GO:0030621,GO:0030622,GO:0032797,GO:0034718,GO:0034719,GO:0043022,GO:0051170,GO:0065003,GO:0097504" "RNA 7-methylguanosine cap binding|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|protein binding|nucleoplasm|cytoplasm|cytosol|translation|regulation of translation|membrane|nuclear body|snRNA binding|U1 snRNA binding|U4 snRNA binding|U4atac snRNA binding|SMN complex|SMN-Gemin2 complex|SMN-Sm protein complex|ribosome binding|import into nucleus|protein-containing complex assembly|Gemini of coiled bodies" hsa03013 RNA transport GEMIN6 190.3057279 178.6322504 201.9792054 1.130698432 0.1772142 0.753138786 1 2.441860542 2.879940907 79833 gem nuclear organelle associated protein 6 "GO:0000245,GO:0000387,GO:0000398,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0016604,GO:0032797,GO:0034719,GO:0051170,GO:0097504" "spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|protein binding|nucleoplasm|cytoplasm|cytosol|nuclear body|SMN complex|SMN-Sm protein complex|import into nucleus|Gemini of coiled bodies" hsa03013 RNA transport GEMIN7 258.8179774 282.1577592 235.4781956 0.834562183 -0.260908546 0.602083177 1 9.23145679 8.03609149 79760 gem nuclear organelle associated protein 7 "GO:0000387,GO:0000398,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0016604,GO:0032797,GO:0034719,GO:0051170,GO:0097504,GO:0120114" "spliceosomal snRNP assembly|mRNA splicing, via spliceosome|protein binding|nucleoplasm|cytoplasm|cytosol|nuclear body|SMN complex|SMN-Sm protein complex|import into nucleus|Gemini of coiled bodies|Sm-like protein family complex" hsa03013 RNA transport GEMIN8 219.6179632 262.8735958 176.3623306 0.670901655 -0.575826792 0.27127865 1 1.953575974 1.367115158 54960 gem nuclear organelle associated protein 8 "GO:0000387,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0032797,GO:0034719,GO:0051170,GO:0097504" spliceosomal snRNP assembly|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|SMN complex|SMN-Sm protein complex|import into nucleus|Gemini of coiled bodies hsa03013 RNA transport GEN1 473.206022 423.2366388 523.1754052 1.236129761 0.305830196 0.461651186 1 3.614745812 4.660770899 348654 GEN1 Holliday junction 5' flap endonuclease "GO:0000287,GO:0000400,GO:0000724,GO:0005654,GO:0005813,GO:0008821,GO:0010824,GO:0017108,GO:0031297,GO:0042803,GO:0071139,GO:0071140,GO:0090267,GO:0090305" magnesium ion binding|four-way junction DNA binding|double-strand break repair via homologous recombination|nucleoplasm|centrosome|crossover junction endodeoxyribonuclease activity|regulation of centrosome duplication|5'-flap endonuclease activity|replication fork processing|protein homodimerization activity|resolution of recombination intermediates|resolution of mitotic recombination intermediates|positive regulation of mitotic cell cycle spindle assembly checkpoint|nucleic acid phosphodiester bond hydrolysis GET1 247.8019195 269.9782876 225.6255514 0.835717396 -0.258912929 0.610187289 1 8.163252442 7.116043575 7485 guided entry of tail-anchored proteins factor 1 "GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0016021,GO:0071816" protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|tail-anchored membrane protein insertion into ER membrane GET3 1450.593028 1467.62633 1433.559726 0.976787958 -0.03388268 0.921004295 1 54.49420539 55.52218526 439 "guided entry of tail-anchored proteins factor 3, ATPase" "GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005789,GO:0006620,GO:0015105,GO:0015700,GO:0016887,GO:0036498,GO:0043529,GO:0046872,GO:0070062,GO:0071816" protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum membrane|posttranslational protein targeting to endoplasmic reticulum membrane|arsenite transmembrane transporter activity|arsenite transport|ATPase activity|IRE1-mediated unfolded protein response|GET complex|metal ion binding|extracellular exosome|tail-anchored membrane protein insertion into ER membrane GET4 1180.246072 1239.261237 1121.230906 0.904757506 -0.144396924 0.674983174 1 30.0307224 28.34091737 51608 guided entry of tail-anchored proteins factor 4 "GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0045048,GO:0051087,GO:0051220,GO:0071816,GO:0071818,GO:1904378" protein binding|nucleoplasm|chromosome|nucleolus|cytoplasm|cytosol|protein insertion into ER membrane|chaperone binding|cytoplasmic sequestering of protein|tail-anchored membrane protein insertion into ER membrane|BAT3 complex|maintenance of unfolded protein involved in ERAD pathway GFER 529.7169492 514.582676 544.8512224 1.058821542 0.082459452 0.841851877 1 11.0197874 12.1705979 2671 "growth factor, augmenter of liver regeneration" "GO:0001889,GO:0005515,GO:0005576,GO:0005739,GO:0005758,GO:0005829,GO:0007165,GO:0008083,GO:0015035,GO:0016971,GO:0050660,GO:0055114" liver development|protein binding|extracellular region|mitochondrion|mitochondrial intermembrane space|cytosol|signal transduction|growth factor activity|protein disulfide oxidoreductase activity|flavin-linked sulfhydryl oxidase activity|flavin adenine dinucleotide binding|oxidation-reduction process GFI1 85.2347746 68.00204988 102.4674993 1.506829566 0.591516246 0.410922056 1 0.555494182 0.873091133 2672 growth factor independent 1 transcriptional repressor "GO:0000083,GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0010956,GO:0010957,GO:0010977,GO:0016032,GO:0016363,GO:0016604,GO:0017053,GO:0030097,GO:0032088,GO:0034121,GO:0045892,GO:0046872,GO:0051569,GO:0070105,GO:0071222,GO:1990837" "regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of vitamin D biosynthetic process|negative regulation of neuron projection development|viral process|nuclear matrix|nuclear body|transcription repressor complex|hemopoiesis|negative regulation of NF-kappaB transcription factor activity|regulation of toll-like receptor signaling pathway|negative regulation of transcription, DNA-templated|metal ion binding|regulation of histone H3-K4 methylation|positive regulation of interleukin-6-mediated signaling pathway|cellular response to lipopolysaccharide|sequence-specific double-stranded DNA binding" GFM1 869.6274836 952.0286983 787.2262688 0.826893423 -0.274226701 0.448591057 1 12.68198186 10.93836962 85476 G elongation factor mitochondrial 1 "GO:0003723,GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005759,GO:0070125" RNA binding|translation elongation factor activity|GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial matrix|mitochondrial translational elongation GFM2 1017.593812 1166.184408 869.0032154 0.745167925 -0.424362518 0.227211193 1 14.00263779 10.88378459 84340 GTP dependent ribosome recycling factor mitochondrial 2 "GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005759,GO:0032543,GO:0032790,GO:0070125,GO:0070126" translation elongation factor activity|GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial matrix|mitochondrial translation|ribosome disassembly|mitochondrial translational elongation|mitochondrial translational termination GFOD1 207.0821929 214.1557093 200.0086766 0.933940436 -0.098597553 0.861436509 1 1.012719998 0.986562253 54438 glucose-fructose oxidoreductase domain containing 1 "GO:0005515,GO:0005576,GO:0016491,GO:0055114" protein binding|extracellular region|oxidoreductase activity|oxidation-reduction process GFOD2 510.2519148 497.3284245 523.1754052 1.051971654 0.073095831 0.861668744 1 3.466546963 3.803794581 81577 glucose-fructose oxidoreductase domain containing 2 "GO:0016491,GO:0030198,GO:0031012,GO:0055114" oxidoreductase activity|extracellular matrix organization|extracellular matrix|oxidation-reduction process GFPT1 1497.000171 1710.200807 1283.799535 0.75067181 -0.413745789 0.212300207 1 9.830398097 7.697277473 2673 glutamine--fructose-6-phosphate transaminase 1 "GO:0004360,GO:0005829,GO:0006002,GO:0006047,GO:0006048,GO:0006112,GO:0006487,GO:0006541,GO:0032922,GO:0036498,GO:0070062,GO:0097367" glutamine-fructose-6-phosphate transaminase (isomerizing) activity|cytosol|fructose 6-phosphate metabolic process|UDP-N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|energy reserve metabolic process|protein N-linked glycosylation|glutamine metabolic process|circadian regulation of gene expression|IRE1-mediated unfolded protein response|extracellular exosome|carbohydrate derivative binding "hsa00250,hsa00520,hsa04931" "Alanine, aspartate and glutamate metabolism|Amino sugar and nucleotide sugar metabolism|Insulin resistance" GFPT2 1581.785613 1612.765034 1550.806192 0.961582226 -0.056517865 0.865470737 1 26.92183898 27.00269304 9945 glutamine-fructose-6-phosphate transaminase 2 "GO:0004360,GO:0005515,GO:0005829,GO:0006002,GO:0006047,GO:0006048,GO:0006112,GO:0006487,GO:0006541,GO:0097367,GO:1990830" glutamine-fructose-6-phosphate transaminase (isomerizing) activity|protein binding|cytosol|fructose 6-phosphate metabolic process|UDP-N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|energy reserve metabolic process|protein N-linked glycosylation|glutamine metabolic process|carbohydrate derivative binding|cellular response to leukemia inhibitory factor "hsa00250,hsa00520,hsa04931" "Alanine, aspartate and glutamate metabolism|Amino sugar and nucleotide sugar metabolism|Insulin resistance" GFRA3 9.897181493 3.044867905 16.74949508 5.500893833 2.459666059 0.101534009 1 0.077571337 0.445092698 2676 GDNF family receptor alpha 3 "GO:0000165,GO:0001764,GO:0005102,GO:0005515,GO:0005829,GO:0005886,GO:0007165,GO:0007399,GO:0007411,GO:0007422,GO:0008046,GO:0009897,GO:0016167,GO:0019898,GO:0031225,GO:0035860,GO:0038023,GO:0043235,GO:0048485" MAPK cascade|neuron migration|signaling receptor binding|protein binding|cytosol|plasma membrane|signal transduction|nervous system development|axon guidance|peripheral nervous system development|axon guidance receptor activity|external side of plasma membrane|glial cell-derived neurotrophic factor receptor activity|extrinsic component of membrane|anchored component of membrane|glial cell-derived neurotrophic factor receptor signaling pathway|signaling receptor activity|receptor complex|sympathetic nervous system development GFUS 1583.386235 1755.873825 1410.898644 0.803530769 -0.315574827 0.338162225 1 58.08544409 48.68394411 7264 GDP-L-fucose synthase "GO:0005515,GO:0005829,GO:0007159,GO:0009055,GO:0010595,GO:0019673,GO:0022900,GO:0042351,GO:0042356,GO:0042802,GO:0047918,GO:0050577,GO:0070062,GO:1904906" "protein binding|cytosol|leukocyte cell-cell adhesion|electron transfer activity|positive regulation of endothelial cell migration|GDP-mannose metabolic process|electron transport chain|'de novo' GDP-L-fucose biosynthetic process|GDP-4-dehydro-D-rhamnose reductase activity|identical protein binding|GDP-mannose 3,5-epimerase activity|GDP-L-fucose synthase activity|extracellular exosome|positive regulation of endothelial cell-matrix adhesion via fibronectin" "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GGA1 1501.375961 1504.164745 1498.587178 0.996291917 -0.005359576 0.989372359 1 18.19021919 18.90342371 26088 "golgi associated, gamma adaptin ear containing, ARF binding protein 1" "GO:0003674,GO:0005515,GO:0005654,GO:0005769,GO:0005794,GO:0005829,GO:0006886,GO:0008104,GO:0010008,GO:0016020,GO:0031267,GO:0031901,GO:0032991,GO:0034394,GO:0042147,GO:0043001,GO:0043231,GO:0044267,GO:0045732,GO:1901998,GO:1903441" "molecular_function|protein binding|nucleoplasm|early endosome|Golgi apparatus|cytosol|intracellular protein transport|protein localization|endosome membrane|membrane|small GTPase binding|early endosome membrane|protein-containing complex|protein localization to cell surface|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport|intracellular membrane-bounded organelle|cellular protein metabolic process|positive regulation of protein catabolic process|toxin transport|protein localization to ciliary membrane" hsa04142 Lysosome GGA2 1120.613326 1170.244232 1070.982421 0.915178552 -0.127874854 0.713031587 1 9.294141752 8.872194519 23062 "golgi associated, gamma adaptin ear containing, ARF binding protein 2" "GO:0005515,GO:0005794,GO:0005802,GO:0006886,GO:0010008,GO:0030136,GO:0031267,GO:0031901,GO:0034394,GO:0043001,GO:0044267" protein binding|Golgi apparatus|trans-Golgi network|intracellular protein transport|endosome membrane|clathrin-coated vesicle|small GTPase binding|early endosome membrane|protein localization to cell surface|Golgi to plasma membrane protein transport|cellular protein metabolic process hsa04142 Lysosome GGA3 1178.868136 1111.376785 1246.359487 1.121455391 0.165372234 0.630797009 1 12.76645804 14.93373205 23163 "golgi associated, gamma adaptin ear containing, ARF binding protein 3" "GO:0005515,GO:0005764,GO:0005794,GO:0005802,GO:0006622,GO:0006886,GO:0010008,GO:0031267,GO:0031647,GO:0031648,GO:0031901,GO:0032456,GO:0032991,GO:0034394,GO:0043001,GO:0043130,GO:0044267,GO:0044877,GO:0045732,GO:0055038,GO:1902430" protein binding|lysosome|Golgi apparatus|trans-Golgi network|protein targeting to lysosome|intracellular protein transport|endosome membrane|small GTPase binding|regulation of protein stability|protein destabilization|early endosome membrane|endocytic recycling|protein-containing complex|protein localization to cell surface|Golgi to plasma membrane protein transport|ubiquitin binding|cellular protein metabolic process|protein-containing complex binding|positive regulation of protein catabolic process|recycling endosome membrane|negative regulation of amyloid-beta formation hsa04142 Lysosome GGACT 61.30363726 82.21143344 40.39584108 0.491365244 -1.02513228 0.199009102 1 0.677578369 0.3472801 87769 gamma-glutamylamine cyclotransferase "GO:0005515,GO:0005829,GO:0042219,GO:0061929,GO:0070062" protein binding|cytosol|cellular modified amino acid catabolic process|gamma-glutamylaminecyclotransferase activity|extracellular exosome GGCT 512.9107926 477.0293051 548.79228 1.150437246 0.20218229 0.620740317 1 18.38649273 22.06367023 79017 gamma-glutamylcyclotransferase "GO:0001836,GO:0003839,GO:0005829,GO:0006750,GO:0042803,GO:0070062" release of cytochrome c from mitochondria|gamma-glutamylcyclotransferase activity|cytosol|glutathione biosynthetic process|protein homodimerization activity|extracellular exosome hsa00480 Glutathione metabolism GGCX 898.0759422 1010.896145 785.25574 0.776791705 -0.364400299 0.310604058 1 6.512952995 5.27713802 2677 gamma-glutamyl carboxylase "GO:0005789,GO:0006464,GO:0007596,GO:0008488,GO:0016020,GO:0016021,GO:0017187,GO:0019842" endoplasmic reticulum membrane|cellular protein modification process|blood coagulation|gamma-glutamyl carboxylase activity|membrane|integral component of membrane|peptidyl-glutamic acid carboxylation|vitamin binding hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis GGH 2448.030981 2299.890224 2596.171738 1.128824198 0.174820819 0.584321816 1 50.66608366 59.65674809 8836 gamma-glutamyl hydrolase "GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005773,GO:0005829,GO:0006508,GO:0008238,GO:0008242,GO:0010043,GO:0032868,GO:0034722,GO:0035578,GO:0035580,GO:0042470,GO:0042493,GO:0043312,GO:0045471,GO:0046900,GO:0070062,GO:1904724" protein binding|extracellular region|extracellular space|nucleus|vacuole|cytosol|proteolysis|exopeptidase activity|omega peptidase activity|response to zinc ion|response to insulin|gamma-glutamyl-peptidase activity|azurophil granule lumen|specific granule lumen|melanosome|response to drug|neutrophil degranulation|response to ethanol|tetrahydrofolylpolyglutamate metabolic process|extracellular exosome|tertiary granule lumen "hsa00790,hsa01523" Folate biosynthesis|Antifolate resistance GGN 22.50990222 23.34398727 21.67581716 0.928539624 -0.106964619 0.965745175 1 0.413243832 0.400242084 199720 gametogenetin "GO:0005515,GO:0006302,GO:0007275,GO:0007276,GO:0007283,GO:0030154,GO:0031625" protein binding|double-strand break repair|multicellular organism development|gamete generation|spermatogenesis|cell differentiation|ubiquitin protein ligase binding GGNBP2 1591.951502 1432.102871 1751.800133 1.223236241 0.290703055 0.377373317 1 25.70196962 32.79387033 79893 gametogenetin binding protein 2 "GO:0005634,GO:0005737,GO:0007283,GO:0008285,GO:0010629,GO:0030154,GO:0031410,GO:0033140,GO:0042532,GO:0060716,GO:0061099" nucleus|cytoplasm|spermatogenesis|negative regulation of cell population proliferation|negative regulation of gene expression|cell differentiation|cytoplasmic vesicle|negative regulation of peptidyl-serine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|labyrinthine layer blood vessel development|negative regulation of protein tyrosine kinase activity GGPS1 819.3441097 646.5269519 992.1612675 1.534601558 0.617864125 0.091488069 1 6.919761053 11.07650282 9453 geranylgeranyl diphosphate synthase 1 "GO:0004161,GO:0004311,GO:0004337,GO:0004659,GO:0005515,GO:0005829,GO:0006695,GO:0006720,GO:0008299,GO:0033384,GO:0033386,GO:0042802,GO:0045337,GO:0045540,GO:0046872" dimethylallyltranstransferase activity|farnesyltranstransferase activity|geranyltranstransferase activity|prenyltransferase activity|protein binding|cytosol|cholesterol biosynthetic process|isoprenoid metabolic process|isoprenoid biosynthetic process|geranyl diphosphate biosynthetic process|geranylgeranyl diphosphate biosynthetic process|identical protein binding|farnesyl diphosphate biosynthetic process|regulation of cholesterol biosynthetic process|metal ion binding hsa00900 Terpenoid backbone biosynthesis GGT1 63.15812149 40.59823873 85.71800424 2.111372486 1.07818112 0.173162308 1 0.754553237 1.66176908 2678 gamma-glutamyltransferase 1 "GO:0000048,GO:0002682,GO:0002951,GO:0005515,GO:0005615,GO:0005886,GO:0006412,GO:0006508,GO:0006520,GO:0006536,GO:0006631,GO:0006691,GO:0006750,GO:0006751,GO:0006805,GO:0007283,GO:0016021,GO:0018215,GO:0019344,GO:0031179,GO:0031638,GO:0032355,GO:0032496,GO:0034612,GO:0036374,GO:0050727,GO:0070062,GO:0102953,GO:0103068,GO:1901750" peptidyltransferase activity|regulation of immune system process|leukotriene-C(4) hydrolase|protein binding|extracellular space|plasma membrane|translation|proteolysis|cellular amino acid metabolic process|glutamate metabolic process|fatty acid metabolic process|leukotriene metabolic process|glutathione biosynthetic process|glutathione catabolic process|xenobiotic metabolic process|spermatogenesis|integral component of membrane|protein phosphopantetheinylation|cysteine biosynthetic process|peptide modification|zymogen activation|response to estradiol|response to lipopolysaccharide|response to tumor necrosis factor|glutathione hydrolase activity|regulation of inflammatory response|extracellular exosome|hypoglycin A gamma-glutamyl transpeptidase activity|leukotriene C4 gamma-glutamyl transferase activity|leukotriene D4 biosynthetic process "hsa00430,hsa00480,hsa00590" Taurine and hypotaurine metabolism|Glutathione metabolism|Arachidonic acid metabolism GGT7 1105.598311 952.0286983 1259.167924 1.322615512 0.403393727 0.244514989 1 14.81773049 20.44236946 2686 gamma-glutamyltransferase 7 "GO:0000048,GO:0005515,GO:0005886,GO:0006412,GO:0006508,GO:0006750,GO:0006751,GO:0007283,GO:0016021,GO:0018215,GO:0032355,GO:0032496,GO:0034612,GO:0036374,GO:0102953,GO:0103068,GO:1901750,GO:1902883" peptidyltransferase activity|protein binding|plasma membrane|translation|proteolysis|glutathione biosynthetic process|glutathione catabolic process|spermatogenesis|integral component of membrane|protein phosphopantetheinylation|response to estradiol|response to lipopolysaccharide|response to tumor necrosis factor|glutathione hydrolase activity|hypoglycin A gamma-glutamyl transpeptidase activity|leukotriene C4 gamma-glutamyl transferase activity|leukotriene D4 biosynthetic process|negative regulation of response to oxidative stress "hsa00430,hsa00480" Taurine and hypotaurine metabolism|Glutathione metabolism GHDC 893.6707062 844.4433657 942.8980466 1.116591218 0.159101115 0.659747536 1 17.12778432 19.94854953 84514 GH3 domain containing "GO:0003674,GO:0005576,GO:0005635,GO:0005737,GO:0005783,GO:0008150,GO:0016020,GO:0016881,GO:0034774,GO:0035580,GO:0043312" molecular_function|extracellular region|nuclear envelope|cytoplasm|endoplasmic reticulum|biological_process|membrane|acid-amino acid ligase activity|secretory granule lumen|specific granule lumen|neutrophil degranulation GHITM 5735.268974 5694.917939 5775.62001 1.014170893 0.020300774 0.950509652 1 121.0862734 128.0919936 27069 growth hormone inducible transmembrane protein "GO:0003674,GO:0005515,GO:0005739,GO:0006915,GO:0007007,GO:0031305,GO:0070062,GO:0090201,GO:1905448" molecular_function|protein binding|mitochondrion|apoptotic process|inner mitochondrial membrane organization|integral component of mitochondrial inner membrane|extracellular exosome|negative regulation of release of cytochrome c from mitochondria|positive regulation of mitochondrial ATP synthesis coupled electron transport GHR 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.024662053 0.008323951 2690 growth hormone receptor "GO:0000187,GO:0004896,GO:0004903,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0005887,GO:0006897,GO:0007259,GO:0009897,GO:0009986,GO:0016021,GO:0017046,GO:0019221,GO:0019530,GO:0019838,GO:0019901,GO:0019955,GO:0032870,GO:0036464,GO:0040014,GO:0040018,GO:0042445,GO:0042531,GO:0042802,GO:0042803,GO:0042976,GO:0043235,GO:0046427,GO:0048009,GO:0050731,GO:0060396,GO:0060397,GO:0070064,GO:0070195" activation of MAPK activity|cytokine receptor activity|growth hormone receptor activity|protein binding|extracellular region|extracellular space|cytosol|plasma membrane|integral component of plasma membrane|endocytosis|receptor signaling pathway via JAK-STAT|external side of plasma membrane|cell surface|integral component of membrane|peptide hormone binding|cytokine-mediated signaling pathway|taurine metabolic process|growth factor binding|protein kinase binding|cytokine binding|cellular response to hormone stimulus|cytoplasmic ribonucleoprotein granule|regulation of multicellular organism growth|positive regulation of multicellular organism growth|hormone metabolic process|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|protein homodimerization activity|activation of Janus kinase activity|receptor complex|positive regulation of receptor signaling pathway via JAK-STAT|insulin-like growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|growth hormone receptor signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|proline-rich region binding|growth hormone receptor complex "hsa04060,hsa04080,hsa04151,hsa04630,hsa04935" "Cytokine-cytokine receptor interaction|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Growth hormone synthesis, secretion and action" GHRL 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.072810112 0.055293552 51738 ghrelin and obestatin prepropeptide "GO:0000187,GO:0001664,GO:0001696,GO:0001937,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006006,GO:0007186,GO:0007204,GO:0008154,GO:0008343,GO:0009725,GO:0009755,GO:0016358,GO:0016525,GO:0016608,GO:0030252,GO:0030296,GO:0030424,GO:0031768,GO:0032024,GO:0032095,GO:0032100,GO:0032691,GO:0032715,GO:0032720,GO:0034774,GO:0035483,GO:0035774,GO:0040010,GO:0040013,GO:0040018,GO:0042127,GO:0042322,GO:0043066,GO:0043400,GO:0043627,GO:0046010,GO:0046676,GO:0046697,GO:0050728,GO:0051216,GO:0051461,GO:0051464,GO:0051602,GO:0051965,GO:0051969,GO:0060079,GO:0060124,GO:0060399,GO:0061098,GO:0098685,GO:0098794,GO:0098978,GO:0099170,GO:0099175,GO:0120058,GO:0120162,GO:1903012,GO:1903672,GO:1904000,GO:1904179,GO:1904346,GO:1904349,GO:1905333,GO:1905564" "activation of MAPK activity|G protein-coupled receptor binding|gastric acid secretion|negative regulation of endothelial cell proliferation|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|glucose metabolic process|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|actin polymerization or depolymerization|adult feeding behavior|response to hormone|hormone-mediated signaling pathway|dendrite development|negative regulation of angiogenesis|growth hormone-releasing hormone activity|growth hormone secretion|protein tyrosine kinase activator activity|axon|ghrelin receptor binding|positive regulation of insulin secretion|regulation of response to food|positive regulation of appetite|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|secretory granule lumen|gastric emptying|positive regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of growth rate|negative regulation of locomotion|positive regulation of multicellular organism growth|regulation of cell population proliferation|negative regulation of circadian sleep/wake cycle, REM sleep|negative regulation of apoptotic process|cortisol secretion|response to estrogen|positive regulation of circadian sleep/wake cycle, non-REM sleep|negative regulation of insulin secretion|decidualization|negative regulation of inflammatory response|cartilage development|positive regulation of corticotropin secretion|positive regulation of cortisol secretion|response to electrical stimulus|positive regulation of synapse assembly|regulation of transmission of nerve impulse|excitatory postsynaptic potential|positive regulation of growth hormone secretion|positive regulation of growth hormone receptor signaling pathway|positive regulation of protein tyrosine kinase activity|Schaffer collateral - CA1 synapse|postsynapse|glutamatergic synapse|postsynaptic modulation of chemical synaptic transmission|regulation of postsynapse organization|positive regulation of small intestinal transit|positive regulation of cold-induced thermogenesis|positive regulation of bone development|positive regulation of sprouting angiogenesis|positive regulation of eating behavior|positive regulation of adipose tissue development|positive regulation of gastric mucosal blood circulation|positive regulation of small intestine smooth muscle contraction|regulation of gastric motility|positive regulation of vascular endothelial cell proliferation" "hsa04024,hsa04080,hsa04935" "cAMP signaling pathway|Neuroactive ligand-receptor interaction|Growth hormone synthesis, secretion and action" GID4 385.4783948 353.204677 417.7521126 1.182747964 0.242142677 0.583046287 1 3.513763673 4.334916011 79018 GID complex subunit 4 homolog "GO:0000151,GO:0016567,GO:0043161,GO:0061630" ubiquitin ligase complex|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity GID8 1914.65356 2006.567949 1822.739171 0.908386467 -0.138621882 0.668860093 1 23.26060606 22.03979809 54994 GID complex subunit 8 homolog "GO:0000151,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008284,GO:0016055,GO:0030054,GO:0042803,GO:0043161,GO:0090263" ubiquitin ligase complex|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|positive regulation of cell population proliferation|Wnt signaling pathway|cell junction|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of canonical Wnt signaling pathway GIGYF1 1597.606751 1279.859476 1915.354026 1.496534629 0.581625662 0.077598221 1 9.498881505 14.82774711 64599 GRB10 interacting GYF protein 1 "GO:0005515,GO:0008150,GO:0032991" protein binding|biological_process|protein-containing complex GIGYF2 1487.042368 1534.613424 1439.471313 0.938002555 -0.092336243 0.782294299 1 9.722636495 9.512704363 26058 GRB10 interacting GYF protein 2 "GO:0003723,GO:0005515,GO:0005768,GO:0005783,GO:0005794,GO:0005829,GO:0010494,GO:0016020,GO:0016441,GO:0017148,GO:0032991,GO:0043204,GO:0045296,GO:0048009,GO:0061157,GO:0070064,GO:1990635" RNA binding|protein binding|endosome|endoplasmic reticulum|Golgi apparatus|cytosol|cytoplasmic stress granule|membrane|posttranscriptional gene silencing|negative regulation of translation|protein-containing complex|perikaryon|cadherin binding|insulin-like growth factor receptor signaling pathway|mRNA destabilization|proline-rich region binding|proximal dendrite GIMAP2 20.92808516 16.23929549 25.61687483 1.577462202 0.657605437 0.567107483 1 0.569967448 0.937831779 26157 "GTPase, IMAP family member 2" "GO:0005515,GO:0005525,GO:0005783,GO:0005811,GO:0042802" protein binding|GTP binding|endoplasmic reticulum|lipid droplet|identical protein binding GIN1 76.57523571 82.21143344 70.93903799 0.862885307 -0.212759283 0.787291217 1 0.823032038 0.740774024 54826 gypsy retrotransposon integrase 1 "GO:0003676,GO:0015074" nucleic acid binding|DNA integration GINM1 863.0708477 806.8899949 919.2517006 1.139252818 0.188087939 0.604649076 1 21.03249187 24.99348237 116254 glycoprotein integral membrane 1 "GO:0005515,GO:0016021" protein binding|integral component of membrane GINS1 1751.125645 1503.149789 1999.101501 1.329941644 0.411362943 0.207026976 1 21.83856398 30.29511407 9837 GINS complex subunit 1 "GO:0000811,GO:0001833,GO:0005634,GO:0005654,GO:0005737,GO:0006271,GO:0071162,GO:1902983" GINS complex|inner cell mass cell proliferation|nucleus|nucleoplasm|cytoplasm|DNA strand elongation involved in DNA replication|CMG complex|DNA strand elongation involved in mitotic DNA replication GINS2 300.5877947 275.0530674 326.1225219 1.185671278 0.245704084 0.60631209 1 5.300786734 6.555722484 51659 GINS complex subunit 2 "GO:0000727,GO:0000811,GO:0005515,GO:0005654,GO:0006271,GO:0071162" double-strand break repair via break-induced replication|GINS complex|protein binding|nucleoplasm|DNA strand elongation involved in DNA replication|CMG complex GINS3 298.8844898 293.3222749 304.4467047 1.037925622 0.053703064 0.916810906 1 6.411626432 6.941452778 64785 GINS complex subunit 3 "GO:0000811,GO:0005515,GO:0005654,GO:0006271,GO:0071162,GO:1902975" GINS complex|protein binding|nucleoplasm|DNA strand elongation involved in DNA replication|CMG complex|mitotic DNA replication initiation GINS4 453.1565592 433.3861985 472.9269199 1.091236688 0.125964055 0.767595636 1 5.736926832 6.530015311 84296 GINS complex subunit 4 "GO:0000727,GO:0000811,GO:0001833,GO:0005515,GO:0005654,GO:0005737,GO:0006271,GO:0071162" double-strand break repair via break-induced replication|GINS complex|inner cell mass cell proliferation|protein binding|nucleoplasm|cytoplasm|DNA strand elongation involved in DNA replication|CMG complex GIPC1 1987.271655 1919.281736 2055.261573 1.070849336 0.098755513 0.76038574 1 50.57484345 56.49094615 10755 GIPC PDZ domain containing family member 1 "GO:0003779,GO:0005102,GO:0005515,GO:0005737,GO:0005829,GO:0005903,GO:0005938,GO:0006605,GO:0007186,GO:0007268,GO:0008021,GO:0012506,GO:0014047,GO:0016020,GO:0017022,GO:0030139,GO:0030165,GO:0030511,GO:0031410,GO:0031647,GO:0032435,GO:0032467,GO:0042802,GO:0043197,GO:0043198,GO:0043542,GO:0045296,GO:0048023,GO:0048167,GO:0070062,GO:0098685,GO:0098761,GO:0098978,GO:2000300" actin binding|signaling receptor binding|protein binding|cytoplasm|cytosol|brush border|cell cortex|protein targeting|G protein-coupled receptor signaling pathway|chemical synaptic transmission|synaptic vesicle|vesicle membrane|glutamate secretion|membrane|myosin binding|endocytic vesicle|PDZ domain binding|positive regulation of transforming growth factor beta receptor signaling pathway|cytoplasmic vesicle|regulation of protein stability|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cytokinesis|identical protein binding|dendritic spine|dendritic shaft|endothelial cell migration|cadherin binding|positive regulation of melanin biosynthetic process|regulation of synaptic plasticity|extracellular exosome|Schaffer collateral - CA1 synapse|cellular response to interleukin-7|glutamatergic synapse|regulation of synaptic vesicle exocytosis GIPC2 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.065851831 0.053343237 54810 GIPC PDZ domain containing family member 2 "GO:0003674,GO:0005515,GO:0005737,GO:0008150,GO:0042802,GO:0070062" molecular_function|protein binding|cytoplasm|biological_process|identical protein binding|extracellular exosome GIPC3 243.2197719 259.8287279 226.6108158 0.872154583 -0.19734423 0.701392157 1 2.975222349 2.706629585 126326 GIPC PDZ domain containing family member 3 GO:0005515 protein binding GIPR 31.95898883 29.43372308 34.48425458 1.171589964 0.228467741 0.841698646 1 0.387903783 0.474040653 2696 gastric inhibitory polypeptide receptor "GO:0002029,GO:0004888,GO:0005515,GO:0005886,GO:0006091,GO:0007166,GO:0007186,GO:0007188,GO:0007190,GO:0007204,GO:0007584,GO:0008528,GO:0009749,GO:0016021,GO:0016519,GO:0017046,GO:0031018,GO:0032024,GO:0038192,GO:0043950,GO:0048678,GO:0050796,GO:0051592,GO:0070542" desensitization of G protein-coupled receptor signaling pathway|transmembrane signaling receptor activity|protein binding|plasma membrane|generation of precursor metabolites and energy|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|positive regulation of cytosolic calcium ion concentration|response to nutrient|G protein-coupled peptide receptor activity|response to glucose|integral component of membrane|gastric inhibitory peptide receptor activity|peptide hormone binding|endocrine pancreas development|positive regulation of insulin secretion|gastric inhibitory peptide signaling pathway|positive regulation of cAMP-mediated signaling|response to axon injury|regulation of insulin secretion|response to calcium ion|response to fatty acid "hsa04024,hsa04080" cAMP signaling pathway|Neuroactive ligand-receptor interaction GIT1 1582.648398 1099.197314 2066.099481 1.87964386 0.910459337 0.006016616 0.305427758 15.56780375 30.52241186 28964 GIT ArfGAP 1 "GO:0001957,GO:0005096,GO:0005515,GO:0005739,GO:0005829,GO:0005925,GO:0007420,GO:0007626,GO:0008277,GO:0016020,GO:0032465,GO:0032691,GO:0043547,GO:0044305,GO:0044877,GO:0045454,GO:0045820,GO:0046872,GO:0048013,GO:0048666,GO:0061743,GO:0071222,GO:0099171,GO:0106015,GO:2000300" intramembranous ossification|GTPase activator activity|protein binding|mitochondrion|cytosol|focal adhesion|brain development|locomotory behavior|regulation of G protein-coupled receptor signaling pathway|membrane|regulation of cytokinesis|negative regulation of interleukin-1 beta production|positive regulation of GTPase activity|calyx of Held|protein-containing complex binding|cell redox homeostasis|negative regulation of glycolytic process|metal ion binding|ephrin receptor signaling pathway|neuron development|motor learning|cellular response to lipopolysaccharide|presynaptic modulation of chemical synaptic transmission|negative regulation of inflammatory response to wounding|regulation of synaptic vesicle exocytosis "hsa04144,hsa04810,hsa05120" Endocytosis|Regulation of actin cytoskeleton|Epithelial cell signaling in Helicobacter pylori infection GIT2 1868.031896 1648.288493 2087.775299 1.266632212 0.340997674 0.292669096 1 12.11962795 16.01237477 9815 GIT ArfGAP 2 "GO:0005096,GO:0005515,GO:0005654,GO:0005925,GO:0008277,GO:0043547,GO:0046872" GTPase activator activity|protein binding|nucleoplasm|focal adhesion|regulation of G protein-coupled receptor signaling pathway|positive regulation of GTPase activity|metal ion binding "hsa04144,hsa05135" Endocytosis|Yersinia infection GJA1 154.8010742 243.5894324 66.01271591 0.270999917 -1.883635686 0.001811143 0.132655503 4.001604093 1.131147411 2697 gap junction protein alpha 1 "GO:0000132,GO:0000139,GO:0001937,GO:0002544,GO:0002931,GO:0003104,GO:0003158,GO:0005243,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005764,GO:0005769,GO:0005771,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0005916,GO:0005921,GO:0005922,GO:0005925,GO:0006915,GO:0007165,GO:0007204,GO:0007267,GO:0007283,GO:0007507,GO:0008013,GO:0009268,GO:0009749,GO:0010232,GO:0010628,GO:0010644,GO:0010649,GO:0010652,GO:0014047,GO:0014704,GO:0015075,GO:0015562,GO:0015631,GO:0015867,GO:0016264,GO:0016324,GO:0017124,GO:0022898,GO:0030054,GO:0030165,GO:0030308,GO:0030660,GO:0032024,GO:0032277,GO:0032355,GO:0032496,GO:0032526,GO:0034220,GO:0034405,GO:0034613,GO:0034634,GO:0034775,GO:0035437,GO:0035633,GO:0042908,GO:0042981,GO:0043123,GO:0043231,GO:0043434,GO:0044291,GO:0045121,GO:0045732,GO:0045907,GO:0046697,GO:0046849,GO:0048812,GO:0051924,GO:0055077,GO:0060044,GO:0060348,GO:0061045,GO:0070160,GO:0071253,GO:0071260,GO:0071374,GO:0086014,GO:0086064,GO:0086075,GO:0097718,GO:0120162,GO:0140115,GO:1901164,GO:1903763,GO:1904646,GO:1904707,GO:1905332,GO:1905772,GO:1905867,GO:2000279,GO:2000648,GO:2000810,GO:2000987" establishment of mitotic spindle orientation|Golgi membrane|negative regulation of endothelial cell proliferation|chronic inflammatory response|response to ischemia|positive regulation of glomerular filtration|endothelium development|gap junction channel activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|lysosome|early endosome|multivesicular body|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|fascia adherens|gap junction|connexin complex|focal adhesion|apoptotic process|signal transduction|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|spermatogenesis|heart development|beta-catenin binding|response to pH|response to glucose|vascular transport|positive regulation of gene expression|cell communication by electrical coupling|regulation of cell communication by electrical coupling|positive regulation of cell communication by chemical coupling|glutamate secretion|intercalated disc|ion transmembrane transporter activity|efflux transmembrane transporter activity|tubulin binding|ATP transport|gap junction assembly|apical plasma membrane|SH3 domain binding|regulation of transmembrane transporter activity|cell junction|PDZ domain binding|negative regulation of cell growth|Golgi-associated vesicle membrane|positive regulation of insulin secretion|negative regulation of gonadotropin secretion|response to estradiol|response to lipopolysaccharide|response to retinoic acid|ion transmembrane transport|response to fluid shear stress|cellular protein localization|glutathione transmembrane transporter activity|glutathione transmembrane transport|maintenance of protein localization in endoplasmic reticulum|maintenance of blood-brain barrier|xenobiotic transport|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|response to peptide hormone|cell-cell contact zone|membrane raft|positive regulation of protein catabolic process|positive regulation of vasoconstriction|decidualization|bone remodeling|neuron projection morphogenesis|regulation of calcium ion transport|gap junction hemi-channel activity|negative regulation of cardiac muscle cell proliferation|bone development|negative regulation of wound healing|tight junction|connexin binding|cellular response to mechanical stimulus|cellular response to parathyroid hormone stimulus|atrial cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|gap junction channel activity involved in cardiac conduction electrical coupling|disordered domain specific binding|positive regulation of cold-induced thermogenesis|export across plasma membrane|negative regulation of trophoblast cell migration|gap junction channel activity involved in cell communication by electrical coupling|cellular response to amyloid-beta|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of morphogenesis of an epithelium|positive regulation of mesodermal cell differentiation|epididymis development|negative regulation of DNA biosynthetic process|positive regulation of stem cell proliferation|regulation of bicellular tight junction assembly|positive regulation of behavioral fear response "hsa04540,hsa05412" Gap junction|Arrhythmogenic right ventricular cardiomyopathy GJA3 125.5806351 131.9442759 119.2169944 0.90354048 -0.146338857 0.826516727 1 1.26586704 1.193030746 2700 gap junction protein alpha 3 "GO:0005243,GO:0005887,GO:0005922,GO:0007267,GO:0007601,GO:0055077,GO:0055085,GO:1990349" gap junction channel activity|integral component of plasma membrane|connexin complex|cell-cell signaling|visual perception|gap junction hemi-channel activity|transmembrane transport|gap junction-mediated intercellular transport GJB2 29.37433998 54.80762229 3.941057666 0.071907109 -3.797721783 0.001085197 0.094895204 1.121993824 0.084154671 2706 gap junction protein beta 2 "GO:0002931,GO:0005243,GO:0005509,GO:0005515,GO:0005793,GO:0005829,GO:0005886,GO:0005887,GO:0005921,GO:0005922,GO:0007267,GO:0007568,GO:0007605,GO:0010644,GO:0016264,GO:0016328,GO:0032355,GO:0032496,GO:0032526,GO:0032570,GO:0034599,GO:0042802,GO:0044297,GO:0044752,GO:0046677,GO:0046697,GO:0048471,GO:0048839,GO:0055085,GO:0071377,GO:0071549,GO:0097449,GO:1903763,GO:1905867,GO:1990349" response to ischemia|gap junction channel activity|calcium ion binding|protein binding|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|integral component of plasma membrane|gap junction|connexin complex|cell-cell signaling|aging|sensory perception of sound|cell communication by electrical coupling|gap junction assembly|lateral plasma membrane|response to estradiol|response to lipopolysaccharide|response to retinoic acid|response to progesterone|cellular response to oxidative stress|identical protein binding|cell body|response to human chorionic gonadotropin|response to antibiotic|decidualization|perinuclear region of cytoplasm|inner ear development|transmembrane transport|cellular response to glucagon stimulus|cellular response to dexamethasone stimulus|astrocyte projection|gap junction channel activity involved in cell communication by electrical coupling|epididymis development|gap junction-mediated intercellular transport GJB3 14.89773246 8.119647747 21.67581716 2.669551419 1.416597337 0.254699307 1 0.173735325 0.483773807 2707 gap junction protein beta 3 "GO:0001701,GO:0001890,GO:0005243,GO:0005515,GO:0005737,GO:0005921,GO:0005922,GO:0007267,GO:0007283,GO:0016021,GO:0030054,GO:0043231,GO:0043588,GO:0055085,GO:0071300" in utero embryonic development|placenta development|gap junction channel activity|protein binding|cytoplasm|gap junction|connexin complex|cell-cell signaling|spermatogenesis|integral component of membrane|cell junction|intracellular membrane-bounded organelle|skin development|transmembrane transport|cellular response to retinoic acid GJC1 2881.027476 2634.825694 3127.229258 1.186882785 0.247177464 0.437529654 1 16.52974437 20.46397035 10052 gap junction protein gamma 1 "GO:0001570,GO:0005216,GO:0005243,GO:0005515,GO:0005789,GO:0005886,GO:0005921,GO:0005922,GO:0006936,GO:0007043,GO:0007267,GO:0007268,GO:0007601,GO:0014704,GO:0016021,GO:0016264,GO:0034220,GO:0045202,GO:0048468,GO:0048738,GO:0086014,GO:0086020,GO:0086021,GO:0086053,GO:0086077" vasculogenesis|ion channel activity|gap junction channel activity|protein binding|endoplasmic reticulum membrane|plasma membrane|gap junction|connexin complex|muscle contraction|cell-cell junction assembly|cell-cell signaling|chemical synaptic transmission|visual perception|intercalated disc|integral component of membrane|gap junction assembly|ion transmembrane transport|synapse|cell development|cardiac muscle tissue development|atrial cardiac muscle cell action potential|gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling|SA node cell to atrial cardiac muscle cell communication by electrical coupling|AV node cell to bundle of His cell communication by electrical coupling|gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling GJC2 9.075220612 14.20938356 3.941057666 0.277355992 -1.850189203 0.218517863 1 0.332404226 0.09616566 57165 gap junction protein gamma 2 "GO:0001932,GO:0005243,GO:0005921,GO:0005922,GO:0007267,GO:0007420,GO:0009636,GO:0010628,GO:0010644,GO:0016021,GO:0033270,GO:0043204,GO:0043209,GO:0055085,GO:0070447,GO:1903763,GO:1904427,GO:1990769,GO:2000134" regulation of protein phosphorylation|gap junction channel activity|gap junction|connexin complex|cell-cell signaling|brain development|response to toxic substance|positive regulation of gene expression|cell communication by electrical coupling|integral component of membrane|paranode region of axon|perikaryon|myelin sheath|transmembrane transport|positive regulation of oligodendrocyte progenitor proliferation|gap junction channel activity involved in cell communication by electrical coupling|positive regulation of calcium ion transmembrane transport|proximal neuron projection|negative regulation of G1/S transition of mitotic cell cycle GJD3 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.050322016 0.012738537 125111 gap junction protein delta 3 "GO:0005216,GO:0005243,GO:0005515,GO:0005887,GO:0005922,GO:0007154,GO:0007267,GO:0009749,GO:0009986,GO:0016264,GO:0034220,GO:0086064,GO:0086065,GO:0086075" ion channel activity|gap junction channel activity|protein binding|integral component of plasma membrane|connexin complex|cell communication|cell-cell signaling|response to glucose|cell surface|gap junction assembly|ion transmembrane transport|cell communication by electrical coupling involved in cardiac conduction|cell communication involved in cardiac conduction|gap junction channel activity involved in cardiac conduction electrical coupling GK 193.4221031 223.290313 163.5538931 0.73247196 -0.449154563 0.41139299 1 2.786121368 2.128663261 2710 glycerol kinase "GO:0004370,GO:0005515,GO:0005524,GO:0005739,GO:0005741,GO:0005829,GO:0006071,GO:0006641,GO:0016310,GO:0016773,GO:0019432,GO:0019563,GO:0046167,GO:0070062" "glycerol kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial outer membrane|cytosol|glycerol metabolic process|triglyceride metabolic process|phosphorylation|phosphotransferase activity, alcohol group as acceptor|triglyceride biosynthetic process|glycerol catabolic process|glycerol-3-phosphate biosynthetic process|extracellular exosome" "hsa00561,hsa03320" Glycerolipid metabolism|PPAR signaling pathway GK5 371.0732946 345.0850292 397.0615599 1.150619489 0.202410811 0.651058003 1 1.664825619 1.998096254 256356 glycerol kinase 5 "GO:0004370,GO:0005524,GO:0005739,GO:0006071,GO:0006641,GO:0016310,GO:0016773,GO:0019563,GO:0046167" "glycerol kinase activity|ATP binding|mitochondrion|glycerol metabolic process|triglyceride metabolic process|phosphorylation|phosphotransferase activity, alcohol group as acceptor|glycerol catabolic process|glycerol-3-phosphate biosynthetic process" GKAP1 87.35376119 78.15160956 96.55591282 1.235494872 0.305089022 0.676155222 1 1.749051402 2.254028742 80318 G kinase anchoring protein 1 "GO:0005515,GO:0005794,GO:0007165,GO:0042802,GO:0046628" protein binding|Golgi apparatus|signal transduction|identical protein binding|positive regulation of insulin receptor signaling pathway GLA 851.7051722 871.8471768 831.5631676 0.953794644 -0.068249414 0.853654792 1 33.5022639 33.33074064 2717 galactosidase alpha "GO:0003824,GO:0004557,GO:0005102,GO:0005515,GO:0005576,GO:0005737,GO:0005764,GO:0005794,GO:0006687,GO:0009311,GO:0016139,GO:0016787,GO:0017041,GO:0035578,GO:0042803,GO:0043202,GO:0043312,GO:0045019,GO:0046477,GO:0046479,GO:0051001,GO:0052692,GO:0070062" catalytic activity|alpha-galactosidase activity|signaling receptor binding|protein binding|extracellular region|cytoplasm|lysosome|Golgi apparatus|glycosphingolipid metabolic process|oligosaccharide metabolic process|glycoside catabolic process|hydrolase activity|galactosylgalactosylglucosylceramidase activity|azurophil granule lumen|protein homodimerization activity|lysosomal lumen|neutrophil degranulation|negative regulation of nitric oxide biosynthetic process|glycosylceramide catabolic process|glycosphingolipid catabolic process|negative regulation of nitric-oxide synthase activity|raffinose alpha-galactosidase activity|extracellular exosome "hsa00052,hsa00561,hsa00600,hsa00603,hsa04142" Galactose metabolism|Glycerolipid metabolism|Sphingolipid metabolism|Glycosphingolipid biosynthesis - globo and isoglobo series|Lysosome GLB1 3189.561966 3217.41042 3161.713513 0.982688902 -0.025193332 0.937861367 1 49.60441017 50.84547057 2720 galactosidase beta 1 "GO:0004565,GO:0005515,GO:0005576,GO:0005737,GO:0005773,GO:0005794,GO:0006027,GO:0006687,GO:0016936,GO:0019388,GO:0035578,GO:0042340,GO:0042803,GO:0043202,GO:0043231,GO:0043312,GO:0044262,GO:0048471,GO:0051413,GO:0070062,GO:1904016,GO:1904813" beta-galactosidase activity|protein binding|extracellular region|cytoplasm|vacuole|Golgi apparatus|glycosaminoglycan catabolic process|glycosphingolipid metabolic process|galactoside binding|galactose catabolic process|azurophil granule lumen|keratan sulfate catabolic process|protein homodimerization activity|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|cellular carbohydrate metabolic process|perinuclear region of cytoplasm|response to cortisone|extracellular exosome|response to Thyroglobulin triiodothyronine|ficolin-1-rich granule lumen "hsa00052,hsa00511,hsa00531,hsa00600,hsa00604,hsa04142" Galactose metabolism|Other glycan degradation|Glycosaminoglycan degradation|Sphingolipid metabolism|Glycosphingolipid biosynthesis - ganglio series|Lysosome GLB1L 151.9425204 149.1985274 154.6865134 1.036783111 0.052114123 0.941330795 1 2.83647863 3.067491442 79411 galactosidase beta 1 like "GO:0004565,GO:0005576,GO:0005773,GO:0005975" beta-galactosidase activity|extracellular region|vacuole|carbohydrate metabolic process GLCCI1 222.7155332 171.5275587 273.9035078 1.596848401 0.675227355 0.195062602 1 1.832369908 3.052057901 113263 glucocorticoid induced 1 GO:0005737 cytoplasm GLCE 827.0641592 803.845127 850.2831915 1.057769915 0.081025848 0.827048465 1 4.994714745 5.510840361 26035 glucuronic acid epimerase "GO:0000139,GO:0005509,GO:0005794,GO:0015012,GO:0016021,GO:0016857,GO:0030210,GO:0042803,GO:0047464" "Golgi membrane|calcium ion binding|Golgi apparatus|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|racemase and epimerase activity, acting on carbohydrates and derivatives|heparin biosynthetic process|protein homodimerization activity|heparosan-N-sulfate-glucuronate 5-epimerase activity" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin GLDC 6.030352707 8.119647747 3.941057666 0.485372985 -1.042834281 0.589955466 1 0.10700794 0.054176075 2731 glycine decarboxylase "GO:0004375,GO:0005654,GO:0005739,GO:0005759,GO:0005886,GO:0005960,GO:0006546,GO:0009055,GO:0016594,GO:0016829,GO:0019464,GO:0019899,GO:0022900,GO:0030170,GO:0036255,GO:0042803,GO:0065003,GO:0070280,GO:1903442" glycine dehydrogenase (decarboxylating) activity|nucleoplasm|mitochondrion|mitochondrial matrix|plasma membrane|glycine cleavage complex|glycine catabolic process|electron transfer activity|glycine binding|lyase activity|glycine decarboxylation via glycine cleavage system|enzyme binding|electron transport chain|pyridoxal phosphate binding|response to methylamine|protein homodimerization activity|protein-containing complex assembly|pyridoxal binding|response to lipoic acid "hsa00260,hsa00630" "Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism" GLDN 19.49472587 19.2841634 19.70528833 1.021837864 0.0311663 1 1 0.120577141 0.128517688 342035 gliomedin "GO:0005581,GO:0005615,GO:0005886,GO:0009986,GO:0016021,GO:0030424,GO:0032528,GO:0034113,GO:0045162,GO:0086080" collagen trimer|extracellular space|plasma membrane|cell surface|integral component of membrane|axon|microvillus organization|heterotypic cell-cell adhesion|clustering of voltage-gated sodium channels|protein binding involved in heterotypic cell-cell adhesion GLE1 1464.795731 1394.549501 1535.041961 1.100743975 0.138478948 0.678138833 1 18.8746693 21.67113203 2733 GLE1 RNA export mediator "GO:0000822,GO:0005515,GO:0005543,GO:0005615,GO:0005635,GO:0005643,GO:0005730,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0006406,GO:0006446,GO:0006449,GO:0016020,GO:0016973,GO:0031369,GO:0031965,GO:0036064,GO:0042802,GO:0044614" inositol hexakisphosphate binding|protein binding|phospholipid binding|extracellular space|nuclear envelope|nuclear pore|nucleolus|cytoplasm|centrosome|centriole|cytosol|mRNA export from nucleus|regulation of translational initiation|regulation of translational termination|membrane|poly(A)+ mRNA export from nucleus|translation initiation factor binding|nuclear membrane|ciliary basal body|identical protein binding|nuclear pore cytoplasmic filaments "hsa03013,hsa03015,hsa05014" RNA transport|mRNA surveillance pathway|Amyotrophic lateral sclerosis GLG1 4705.271274 5061.585414 4348.957135 0.859208485 -0.218919855 0.494368447 1 27.60325671 24.73858249 2734 golgi glycoprotein 1 "GO:0000139,GO:0005102,GO:0005794,GO:0005856,GO:0005886,GO:0010955,GO:0016020,GO:0016021,GO:0017134,GO:0030512,GO:0031012,GO:0032330,GO:0050900,GO:0060349,GO:0070062,GO:0150051" Golgi membrane|signaling receptor binding|Golgi apparatus|cytoskeleton|plasma membrane|negative regulation of protein processing|membrane|integral component of membrane|fibroblast growth factor binding|negative regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|regulation of chondrocyte differentiation|leukocyte migration|bone morphogenesis|extracellular exosome|postsynaptic Golgi apparatus hsa04514 Cell adhesion molecules GLI1 26.03255656 28.41876711 23.646346 0.832067975 -0.265226703 0.827971702 1 0.354335376 0.307531248 2735 GLI family zinc finger 1 "GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001649,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005930,GO:0006357,GO:0007224,GO:0007283,GO:0007418,GO:0008017,GO:0008284,GO:0008589,GO:0009611,GO:0009913,GO:0009953,GO:0009954,GO:0021696,GO:0021938,GO:0021983,GO:0030324,GO:0030850,GO:0045667,GO:0045740,GO:0045880,GO:0045893,GO:0045944,GO:0046872,GO:0048546,GO:0060032,GO:0060045,GO:0060070,GO:0090090,GO:0097421,GO:0097542,GO:0097546,GO:1902808,GO:2000345" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|osteoblast differentiation|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|axoneme|regulation of transcription by RNA polymerase II|smoothened signaling pathway|spermatogenesis|ventral midline development|microtubule binding|positive regulation of cell population proliferation|regulation of smoothened signaling pathway|response to wounding|epidermal cell differentiation|dorsal/ventral pattern formation|proximal/distal pattern formation|cerebellar cortex morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|pituitary gland development|lung development|prostate gland development|regulation of osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|digestive tract morphogenesis|notochord regression|positive regulation of cardiac muscle cell proliferation|canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|liver regeneration|ciliary tip|ciliary base|positive regulation of cell cycle G1/S phase transition|regulation of hepatocyte proliferation" "hsa04024,hsa04340,hsa05200,hsa05217" cAMP signaling pathway|Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma zf-C2H2 GLI2 54.70914507 35.52345889 73.89483124 2.080169937 1.056701392 0.202188173 1 0.182338895 0.395634416 2736 GLI family zinc finger 2 "GO:0000122,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0001701,GO:0001822,GO:0002062,GO:0002076,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005929,GO:0005930,GO:0006357,GO:0007224,GO:0007389,GO:0007411,GO:0007418,GO:0007442,GO:0007507,GO:0008134,GO:0008270,GO:0009952,GO:0009954,GO:0016020,GO:0016607,GO:0021508,GO:0021513,GO:0021517,GO:0021696,GO:0021775,GO:0021776,GO:0021938,GO:0021965,GO:0021983,GO:0030324,GO:0030879,GO:0030902,GO:0031069,GO:0031514,GO:0032331,GO:0033089,GO:0035295,GO:0042475,GO:0042733,GO:0043066,GO:0043565,GO:0045666,GO:0045740,GO:0045879,GO:0045893,GO:0045944,GO:0048566,GO:0048589,GO:0048666,GO:0048754,GO:0060032,GO:0060513,GO:0060603,GO:0060831,GO:0071407,GO:0090103,GO:0097542,GO:0097546,GO:1901620,GO:1990837,GO:1990841" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|in utero embryonic development|kidney development|chondrocyte differentiation|osteoblast development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|cilium|axoneme|regulation of transcription by RNA polymerase II|smoothened signaling pathway|pattern specification process|axon guidance|ventral midline development|hindgut morphogenesis|heart development|transcription factor binding|zinc ion binding|anterior/posterior pattern specification|proximal/distal pattern formation|membrane|nuclear speck|floor plate formation|spinal cord dorsal/ventral patterning|ventral spinal cord development|cerebellar cortex morphogenesis|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|spinal cord ventral commissure morphogenesis|pituitary gland development|lung development|mammary gland development|hindbrain development|hair follicle morphogenesis|motile cilium|negative regulation of chondrocyte differentiation|positive regulation of T cell differentiation in thymus|tube development|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|negative regulation of apoptotic process|sequence-specific DNA binding|positive regulation of neuron differentiation|positive regulation of DNA replication|negative regulation of smoothened signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic digestive tract development|developmental growth|neuron development|branching morphogenesis of an epithelial tube|notochord regression|prostatic bud formation|mammary gland duct morphogenesis|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|cellular response to organic cyclic compound|cochlea morphogenesis|ciliary tip|ciliary base|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" "hsa04340,hsa04390,hsa05200,hsa05217" Hedgehog signaling pathway|Hippo signaling pathway|Pathways in cancer|Basal cell carcinoma zf-C2H2 GLI3 904.9688338 875.9070007 934.0306669 1.066358262 0.092692218 0.798489293 1 3.142646612 3.495542731 2737 GLI family zinc finger 3 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001656,GO:0001658,GO:0001701,GO:0002052,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005929,GO:0005930,GO:0006357,GO:0007224,GO:0007411,GO:0007442,GO:0007507,GO:0008013,GO:0008285,GO:0009952,GO:0009954,GO:0016485,GO:0016607,GO:0017053,GO:0021631,GO:0021766,GO:0021775,GO:0021776,GO:0021798,GO:0021819,GO:0021861,GO:0022018,GO:0030318,GO:0030324,GO:0030850,GO:0032332,GO:0033077,GO:0035035,GO:0035108,GO:0036033,GO:0042060,GO:0042307,GO:0042475,GO:0042733,GO:0042826,GO:0043066,GO:0043231,GO:0043585,GO:0043586,GO:0043627,GO:0045060,GO:0045665,GO:0045669,GO:0045879,GO:0045892,GO:0045893,GO:0045944,GO:0046638,GO:0046639,GO:0046872,GO:0048557,GO:0048566,GO:0048589,GO:0048593,GO:0048702,GO:0048709,GO:0060021,GO:0060364,GO:0060366,GO:0060367,GO:0060594,GO:0060831,GO:0060840,GO:0060873,GO:0060875,GO:0061005,GO:0070242,GO:0071625,GO:0090090,GO:0097421,GO:0097542,GO:0097546,GO:0120223,GO:1901620,GO:1903010,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|metanephros development|branching involved in ureteric bud morphogenesis|in utero embryonic development|positive regulation of neuroblast proliferation|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|cilium|axoneme|regulation of transcription by RNA polymerase II|smoothened signaling pathway|axon guidance|hindgut morphogenesis|heart development|beta-catenin binding|negative regulation of cell population proliferation|anterior/posterior pattern specification|proximal/distal pattern formation|protein processing|nuclear speck|transcription repressor complex|optic nerve morphogenesis|hippocampus development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|forebrain dorsal/ventral pattern formation|layer formation in cerebral cortex|forebrain radial glial cell differentiation|lateral ganglionic eminence cell proliferation|melanocyte differentiation|lung development|prostate gland development|positive regulation of chondrocyte differentiation|T cell differentiation in thymus|histone acetyltransferase binding|limb morphogenesis|mediator complex binding|wound healing|positive regulation of protein import into nucleus|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|histone deacetylase binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|nose morphogenesis|tongue development|response to estrogen|negative thymic T cell selection|negative regulation of neuron differentiation|positive regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of alpha-beta T cell differentiation|negative regulation of alpha-beta T cell differentiation|metal ion binding|embryonic digestive tract morphogenesis|embryonic digestive tract development|developmental growth|camera-type eye morphogenesis|embryonic neurocranium morphogenesis|oligodendrocyte differentiation|roof of mouth development|frontal suture morphogenesis|lambdoid suture morphogenesis|sagittal suture morphogenesis|mammary gland specification|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|artery development|anterior semicircular canal development|lateral semicircular canal development|cell differentiation involved in kidney development|thymocyte apoptotic process|vocalization behavior|negative regulation of canonical Wnt signaling pathway|liver regeneration|ciliary tip|ciliary base|larynx morphogenesis|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|regulation of bone development|sequence-specific double-stranded DNA binding" "hsa04024,hsa04340,hsa05200,hsa05217" cAMP signaling pathway|Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma GLI4 202.9926775 204.0061496 201.9792054 0.990064298 -0.014405873 0.98897359 1 7.739469505 7.992644989 2738 GLI family zinc finger 4 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" zf-C2H2 GLIPR1 1156.734575 1416.878532 896.5906191 0.63279286 -0.660194772 0.055457537 1 12.19576805 8.049829023 11010 GLI pathogenesis related 1 "GO:0005515,GO:0005615,GO:0005886,GO:0016020,GO:0016021,GO:0019216,GO:0035577,GO:0043312" protein binding|extracellular space|plasma membrane|membrane|integral component of membrane|regulation of lipid metabolic process|azurophil granule membrane|neutrophil degranulation GLIPR1L2 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.052488706 0.088580095 144321 GLIPR1 like 2 "GO:0005615,GO:0007339,GO:0016021" extracellular space|binding of sperm to zona pellucida|integral component of membrane GLIPR2 820.3778708 784.5609636 856.194778 1.091304332 0.126053482 0.732375934 1 18.82294886 21.42641296 152007 GLI pathogenesis related 2 "GO:0000139,GO:0005615,GO:0010634,GO:0010718,GO:0042803,GO:0070062,GO:0070374" Golgi membrane|extracellular space|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|protein homodimerization activity|extracellular exosome|positive regulation of ERK1 and ERK2 cascade GLIS1 17.00187327 17.25425146 16.74949508 0.970745971 -0.042834281 1 1 0.097562461 0.098788019 148979 GLIS family zinc finger 1 "GO:0000122,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0030154,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 GLIS2 423.7646519 411.0571672 436.4721365 1.061828308 0.08655051 0.844107211 1 4.472308356 4.953383678 84662 GLIS family zinc finger 2 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007417,GO:0016607,GO:0043433,GO:0045879,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0060994,GO:0061005,GO:0061484,GO:0097730,GO:1900182,GO:1990837" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|central nervous system development|nuclear speck|negative regulation of DNA-binding transcription factor activity|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|regulation of transcription from RNA polymerase II promoter involved in kidney development|cell differentiation involved in kidney development|hematopoietic stem cell homeostasis|non-motile cilium|positive regulation of protein localization to nucleus|sequence-specific double-stranded DNA binding" zf-C2H2 GLIS3 1081.832953 1314.367979 849.2979271 0.646164499 -0.630026605 0.070472629 1 4.992357982 3.364842517 169792 GLIS family zinc finger 3 "GO:0000122,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0006366,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 GLMN 201.5296267 205.0211056 198.0381477 0.965940297 -0.049994073 0.935511429 1 3.33555918 3.36073961 11146 "glomulin, FKBP associated protein" "GO:0001570,GO:0001819,GO:0001843,GO:0005102,GO:0005171,GO:0005515,GO:0005737,GO:0007166,GO:0008285,GO:0031397,GO:0031461,GO:0031462,GO:0031463,GO:0031464,GO:0031625,GO:0032434,GO:0032743,GO:0040029,GO:0042130,GO:0042327,GO:0042692,GO:0055105" "vasculogenesis|positive regulation of cytokine production|neural tube closure|signaling receptor binding|hepatocyte growth factor receptor binding|protein binding|cytoplasm|cell surface receptor signaling pathway|negative regulation of cell population proliferation|negative regulation of protein ubiquitination|cullin-RING ubiquitin ligase complex|Cul2-RING ubiquitin ligase complex|Cul3-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of interleukin-2 production|regulation of gene expression, epigenetic|negative regulation of T cell proliferation|positive regulation of phosphorylation|muscle cell differentiation|ubiquitin-protein transferase inhibitor activity" hsa05131 Shigellosis GLMP 1120.298843 1182.423703 1058.173983 0.894919461 -0.160170243 0.644404175 1 31.19041105 29.11528064 112770 glycosylated lysosomal membrane protein "GO:0005634,GO:0005764,GO:0005765,GO:0005829,GO:0016021,GO:0045944,GO:0050821,GO:0061462" nucleus|lysosome|lysosomal membrane|cytosol|integral component of membrane|positive regulation of transcription by RNA polymerase II|protein stabilization|protein localization to lysosome GLO1 2909.495978 2998.179931 2820.812025 0.940841474 -0.087976437 0.78292119 1 75.32104987 73.91775158 2739 glyoxalase I "GO:0004462,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006090,GO:0006357,GO:0006749,GO:0008270,GO:0009438,GO:0030316,GO:0043066,GO:0070062" lactoylglutathione lyase activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|carbohydrate metabolic process|pyruvate metabolic process|regulation of transcription by RNA polymerase II|glutathione metabolic process|zinc ion binding|methylglyoxal metabolic process|osteoclast differentiation|negative regulation of apoptotic process|extracellular exosome hsa00620 Pyruvate metabolism GLOD4 1336.280829 1365.115777 1307.445881 0.957754575 -0.062272083 0.855176834 1 19.55268617 19.53334382 51031 glyoxalase domain containing 4 "GO:0005739,GO:0045296,GO:0070062" mitochondrion|cadherin binding|extracellular exosome GLRB 61.00672174 61.91231407 60.10112941 0.970745971 -0.042834281 0.980081854 1 1.25125311 1.266971064 2743 glycine receptor beta "GO:0001964,GO:0004888,GO:0005254,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006811,GO:0007165,GO:0007218,GO:0007268,GO:0007340,GO:0007399,GO:0007601,GO:0007628,GO:0016594,GO:0016933,GO:0016934,GO:0016935,GO:0030425,GO:0030594,GO:0034220,GO:0042391,GO:0043005,GO:0043200,GO:0044877,GO:0045202,GO:0045211,GO:0050877,GO:0060012,GO:0060013,GO:0060079,GO:0097112,GO:0098690,GO:0098982,GO:1902476,GO:1904315" "startle response|transmembrane signaling receptor activity|chloride channel activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|ion transport|signal transduction|neuropeptide signaling pathway|chemical synaptic transmission|acrosome reaction|nervous system development|visual perception|adult walking behavior|glycine binding|extracellularly glycine-gated ion channel activity|extracellularly glycine-gated chloride channel activity|glycine-gated chloride channel complex|dendrite|neurotransmitter receptor activity|ion transmembrane transport|regulation of membrane potential|neuron projection|response to amino acid|protein-containing complex binding|synapse|postsynaptic membrane|nervous system process|synaptic transmission, glycinergic|righting reflex|excitatory postsynaptic potential|gamma-aminobutyric acid receptor clustering|glycinergic synapse|GABA-ergic synapse|chloride transmembrane transport|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" hsa04080 Neuroactive ligand-receptor interaction GLRX 346.2877832 401.9225635 290.6530029 0.72315672 -0.467619757 0.301714971 1 21.58638382 16.2827686 2745 glutaredoxin "GO:0005515,GO:0005634,GO:0005829,GO:0009055,GO:0015038,GO:0015949,GO:0022900,GO:0045838,GO:0047485,GO:0070062,GO:0080058,GO:0097573,GO:2000651" protein binding|nucleus|cytosol|electron transfer activity|glutathione disulfide oxidoreductase activity|nucleobase-containing small molecule interconversion|electron transport chain|positive regulation of membrane potential|protein N-terminus binding|extracellular exosome|protein deglutathionylation|glutathione oxidoreductase activity|positive regulation of sodium ion transmembrane transporter activity GLRX2 219.6949137 234.4548287 204.9349986 0.87409161 -0.194143605 0.715942162 1 9.240708145 8.425159573 51022 glutaredoxin 2 "GO:0003756,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0006355,GO:0006749,GO:0006915,GO:0007568,GO:0008794,GO:0009055,GO:0009266,GO:0009966,GO:0010033,GO:0015035,GO:0015038,GO:0018215,GO:0022900,GO:0030154,GO:0030425,GO:0042262,GO:0042542,GO:0043025,GO:0043231,GO:0045454,GO:0046872,GO:0051537,GO:0051775,GO:0071451" "protein disulfide isomerase activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|regulation of transcription, DNA-templated|glutathione metabolic process|apoptotic process|aging|arsenate reductase (glutaredoxin) activity|electron transfer activity|response to temperature stimulus|regulation of signal transduction|response to organic substance|protein disulfide oxidoreductase activity|glutathione disulfide oxidoreductase activity|protein phosphopantetheinylation|electron transport chain|cell differentiation|dendrite|DNA protection|response to hydrogen peroxide|neuronal cell body|intracellular membrane-bounded organelle|cell redox homeostasis|metal ion binding|2 iron, 2 sulfur cluster binding|response to redox state|cellular response to superoxide" GLRX3 1080.685869 1101.227226 1060.144512 0.9626937 -0.054851246 0.877126187 1 14.22787604 14.28710157 10539 glutaredoxin 3 "GO:0002026,GO:0003723,GO:0005080,GO:0005515,GO:0005634,GO:0005829,GO:0005938,GO:0006879,GO:0010614,GO:0015035,GO:0030018,GO:0030425,GO:0042802,GO:0044571,GO:0046872,GO:0051536,GO:0055114,GO:0097428" regulation of the force of heart contraction|RNA binding|protein kinase C binding|protein binding|nucleus|cytosol|cell cortex|cellular iron ion homeostasis|negative regulation of cardiac muscle hypertrophy|protein disulfide oxidoreductase activity|Z disc|dendrite|identical protein binding|[2Fe-2S] cluster assembly|metal ion binding|iron-sulfur cluster binding|oxidation-reduction process|protein maturation by iron-sulfur cluster transfer GLRX5 728.8225089 789.6357434 668.0092744 0.845971424 -0.241319163 0.520330142 1 36.25771961 31.99426291 51218 glutaredoxin 5 "GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0015035,GO:0030097,GO:0030425,GO:0043025,GO:0044281,GO:0044571,GO:0046872,GO:0051537,GO:0055114,GO:0106034,GO:0106035" "protein binding|nucleus|mitochondrion|mitochondrial matrix|protein disulfide oxidoreductase activity|hemopoiesis|dendrite|neuronal cell body|small molecule metabolic process|[2Fe-2S] cluster assembly|metal ion binding|2 iron, 2 sulfur cluster binding|oxidation-reduction process|protein maturation by [2Fe-2S] cluster transfer|protein maturation by [4Fe-4S] cluster transfer" GLS 1033.467406 1106.302006 960.6328061 0.868327818 -0.203688292 0.56194736 1 4.946613735 4.480305651 2744 glutaminase "GO:0001967,GO:0002087,GO:0004359,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0006537,GO:0006543,GO:0007268,GO:0008652,GO:0014047,GO:0045202,GO:0051289,GO:0090461" suckling behavior|regulation of respiratory gaseous exchange by nervous system process|glutaminase activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|glutamate biosynthetic process|glutamine catabolic process|chemical synaptic transmission|cellular amino acid biosynthetic process|glutamate secretion|synapse|protein homotetramerization|glutamate homeostasis "hsa00220,hsa00250,hsa00471,hsa04724,hsa04727,hsa04964,hsa05206,hsa05230" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Glutamatergic synapse|GABAergic synapse|Proximal tubule bicarbonate reclamation|MicroRNAs in cancer|Central carbon metabolism in cancer" GLS2 16.59831572 23.34398727 9.852644165 0.422063465 -1.244468142 0.298460188 1 0.474434431 0.208867029 27165 glutaminase 2 "GO:0004359,GO:0005515,GO:0005739,GO:0005759,GO:0006520,GO:0006537,GO:0006543,GO:0008652,GO:0014047,GO:0042981,GO:0072593" glutaminase activity|protein binding|mitochondrion|mitochondrial matrix|cellular amino acid metabolic process|glutamate biosynthetic process|glutamine catabolic process|cellular amino acid biosynthetic process|glutamate secretion|regulation of apoptotic process|reactive oxygen species metabolic process "hsa00220,hsa00250,hsa00471,hsa04724,hsa04727,hsa04964,hsa05206,hsa05230" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Glutamatergic synapse|GABAergic synapse|Proximal tubule bicarbonate reclamation|MicroRNAs in cancer|Central carbon metabolism in cancer" GLT8D1 1159.585211 1241.291149 1077.879272 0.868353305 -0.203645947 0.55449318 1 26.28219804 23.80532278 55830 glycosyltransferase 8 domain containing 1 "GO:0005794,GO:0016020,GO:0016021,GO:0016757" "Golgi apparatus|membrane|integral component of membrane|transferase activity, transferring glycosyl groups" GLT8D2 380.4360281 311.5914823 449.2805739 1.44188978 0.527960888 0.230440812 1 4.931565422 7.417077078 83468 glycosyltransferase 8 domain containing 2 "GO:0005794,GO:0016021,GO:0016757" "Golgi apparatus|integral component of membrane|transferase activity, transferring glycosyl groups" GLTP 1672.272079 1534.613424 1809.930733 1.179404992 0.238059206 0.467483411 1 29.42929047 36.20417729 51228 glycolipid transfer protein "GO:0005515,GO:0005829,GO:0006687,GO:0008289,GO:0016020,GO:0017089,GO:0035627,GO:0042802,GO:0046836,GO:0051861,GO:0120009,GO:0120013,GO:1902387,GO:1902388,GO:1902389" protein binding|cytosol|glycosphingolipid metabolic process|lipid binding|membrane|glycolipid transfer activity|ceramide transport|identical protein binding|glycolipid transport|glycolipid binding|intermembrane lipid transfer|lipid transfer activity|ceramide 1-phosphate binding|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport GLUD1 4130.928922 4055.76405 4206.093794 1.037065703 0.052507298 0.86987497 1 53.10500032 57.44571209 2746 glutamate dehydrogenase 1 "GO:0004352,GO:0004353,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005759,GO:0005783,GO:0006537,GO:0006538,GO:0006541,GO:0008652,GO:0021762,GO:0032024,GO:0042802,GO:0043531,GO:0055114,GO:0070403,GO:0070728,GO:0072350" glutamate dehydrogenase (NAD+) activity|glutamate dehydrogenase [NAD(P)+] activity|protein binding|ATP binding|GTP binding|cytoplasm|mitochondrion|mitochondrial matrix|endoplasmic reticulum|glutamate biosynthetic process|glutamate catabolic process|glutamine metabolic process|cellular amino acid biosynthetic process|substantia nigra development|positive regulation of insulin secretion|identical protein binding|ADP binding|oxidation-reduction process|NAD+ binding|leucine binding|tricarboxylic acid metabolic process "hsa00220,hsa00250,hsa00471,hsa00910,hsa04217,hsa04964" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Nitrogen metabolism|Necroptosis|Proximal tubule bicarbonate reclamation" GLUD2 10.97152057 9.134603715 12.80843742 1.402188624 0.487680435 0.768959523 1 0.186171209 0.272292003 2747 glutamate dehydrogenase 2 "GO:0004352,GO:0004353,GO:0005525,GO:0005739,GO:0005759,GO:0005829,GO:0006536,GO:0006537,GO:0006538,GO:0043531,GO:0055114,GO:0070728" glutamate dehydrogenase (NAD+) activity|glutamate dehydrogenase [NAD(P)+] activity|GTP binding|mitochondrion|mitochondrial matrix|cytosol|glutamate metabolic process|glutamate biosynthetic process|glutamate catabolic process|ADP binding|oxidation-reduction process|leucine binding "hsa00220,hsa00250,hsa00471,hsa00910,hsa04217,hsa04964" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Nitrogen metabolism|Necroptosis|Proximal tubule bicarbonate reclamation" GLUL 1498.890036 1233.171502 1764.60857 1.430951468 0.516974742 0.119303091 1 7.540237376 11.25449085 2752 glutamate-ammonia ligase "GO:0001504,GO:0001525,GO:0004356,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0006538,GO:0006542,GO:0008283,GO:0008652,GO:0010594,GO:0018215,GO:0018345,GO:0019706,GO:0042254,GO:0042802,GO:0046872,GO:0070062,GO:1903670,GO:1904749" neurotransmitter uptake|angiogenesis|glutamate-ammonia ligase activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|glutamate catabolic process|glutamine biosynthetic process|cell population proliferation|cellular amino acid biosynthetic process|regulation of endothelial cell migration|protein phosphopantetheinylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|ribosome biogenesis|identical protein binding|metal ion binding|extracellular exosome|regulation of sprouting angiogenesis|regulation of protein localization to nucleolus "hsa00220,hsa00250,hsa00630,hsa00910,hsa04217,hsa04724,hsa04727" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Glyoxylate and dicarboxylate metabolism|Nitrogen metabolism|Necroptosis|Glutamatergic synapse|GABAergic synapse" GLYCTK 289.643244 301.4419226 277.8445655 0.921718396 -0.11760205 0.811603207 1 3.689456249 3.547125463 132158 glycerate kinase "GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0006468,GO:0008887,GO:0061624" protein binding|ATP binding|cytoplasm|mitochondrion|Golgi apparatus|cytosol|protein phosphorylation|glycerate kinase activity|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate "hsa00030,hsa00260,hsa00561,hsa00630" "Pentose phosphate pathway|Glycine, serine and threonine metabolism|Glycerolipid metabolism|Glyoxylate and dicarboxylate metabolism" GLYR1 1519.102556 1604.645386 1433.559726 0.893381017 -0.162652496 0.62397221 1 17.3319744 16.15104728 84656 glyoxylate reductase 1 homolog "GO:0000786,GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0005829,GO:0016616,GO:0031491,GO:0035064,GO:0035066,GO:0042393,GO:0045944,GO:0050661,GO:0051287,GO:0055114" "nucleosome|DNA binding|chromatin binding|protein binding|nucleoplasm|cytosol|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|nucleosome binding|methylated histone binding|positive regulation of histone acetylation|histone binding|positive regulation of transcription by RNA polymerase II|NADP binding|NAD binding|oxidation-reduction process" other GM2A 916.783842 976.3876416 857.1800424 0.877909558 -0.187855774 0.600872053 1 13.77837547 12.61722135 2760 GM2 ganglioside activator "GO:0005319,GO:0005576,GO:0005829,GO:0006687,GO:0006689,GO:0006869,GO:0007611,GO:0009313,GO:0009898,GO:0016004,GO:0016323,GO:0016324,GO:0019915,GO:0030290,GO:0032428,GO:0035578,GO:0043202,GO:0043231,GO:0043312,GO:0050885,GO:0051345,GO:0070062" lipid transporter activity|extracellular region|cytosol|glycosphingolipid metabolic process|ganglioside catabolic process|lipid transport|learning or memory|oligosaccharide catabolic process|cytoplasmic side of plasma membrane|phospholipase activator activity|basolateral plasma membrane|apical plasma membrane|lipid storage|sphingolipid activator protein activity|beta-N-acetylgalactosaminidase activity|azurophil granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|neuromuscular process controlling balance|positive regulation of hydrolase activity|extracellular exosome hsa04142 Lysosome GMCL1 436.3031437 426.2815067 446.3247807 1.047018868 0.066287441 0.880671208 1 6.578200635 7.184185758 64395 "germ cell-less 1, spermatogenesis associated" "GO:0005515,GO:0005634,GO:0007275,GO:0007281,GO:0007283,GO:0016363,GO:0042802" protein binding|nucleus|multicellular organism development|germ cell development|spermatogenesis|nuclear matrix|identical protein binding GMDS 193.0333913 230.3950048 155.6717778 0.675673407 -0.56560202 0.300305499 1 1.116087442 0.786594631 2762 "GDP-mannose 4,6-dehydratase" "GO:0005515,GO:0005737,GO:0005829,GO:0007219,GO:0008446,GO:0019673,GO:0042351,GO:0042802,GO:0070062,GO:0070401" "protein binding|cytoplasm|cytosol|Notch signaling pathway|GDP-mannose 4,6-dehydratase activity|GDP-mannose metabolic process|'de novo' GDP-L-fucose biosynthetic process|identical protein binding|extracellular exosome|NADP+ binding" "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GMEB1 180.3194718 169.4976467 191.1412968 1.127692924 0.173374268 0.763085155 1 3.197191007 3.760757825 10691 glucocorticoid modulatory element binding protein 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0042802,GO:0045944,GO:0046872,GO:0051008,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|identical protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding|Hsp27 protein binding|sequence-specific double-stranded DNA binding" SAND GMEB2 1014.017217 1090.06271 937.9717246 0.860475013 -0.216794796 0.538251402 1 11.89823939 10.67915514 26205 glucocorticoid modulatory element binding protein 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0042802,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|identical protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" SAND GMFB 1554.025503 1533.598468 1574.452538 1.026639352 0.037929467 0.910425059 1 19.01379491 20.36116588 2764 glia maturation factor beta "GO:0003779,GO:0004860,GO:0006468,GO:0006469,GO:0007165,GO:0007399,GO:0008047,GO:0008083,GO:0034316,GO:0071846,GO:0071933" actin binding|protein kinase inhibitor activity|protein phosphorylation|negative regulation of protein kinase activity|signal transduction|nervous system development|enzyme activator activity|growth factor activity|negative regulation of Arp2/3 complex-mediated actin nucleation|actin filament debranching|Arp2/3 complex binding GMFG 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.334879083 0 9535 glia maturation factor gamma "GO:0003779,GO:0004860,GO:0005576,GO:0006468,GO:0006469,GO:0007165,GO:0008047,GO:0008083,GO:0034316,GO:0034774,GO:0043312,GO:0071846,GO:0071933,GO:1904813,GO:2000249" actin binding|protein kinase inhibitor activity|extracellular region|protein phosphorylation|negative regulation of protein kinase activity|signal transduction|enzyme activator activity|growth factor activity|negative regulation of Arp2/3 complex-mediated actin nucleation|secretory granule lumen|neutrophil degranulation|actin filament debranching|Arp2/3 complex binding|ficolin-1-rich granule lumen|regulation of actin cytoskeleton reorganization GMIP 352.8216545 276.0680234 429.5752856 1.556048688 0.637887202 0.156587036 1 3.921983584 6.365681171 51291 GEM interacting protein "GO:0005096,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0034260,GO:0035556,GO:0046872,GO:0051056,GO:0090630" GTPase activator activity|protein binding|nucleoplasm|cytosol|plasma membrane|negative regulation of GTPase activity|intracellular signal transduction|metal ion binding|regulation of small GTPase mediated signal transduction|activation of GTPase activity GMNC 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.042342619 0.014291506 647309 geminin coiled-coil domain containing "GO:0003682,GO:0005515,GO:0005634,GO:0006270,GO:0007049,GO:0008156,GO:0045786,GO:0060271" chromatin binding|protein binding|nucleus|DNA replication initiation|cell cycle|negative regulation of DNA replication|negative regulation of cell cycle|cilium assembly GMNN 396.7616767 383.653356 409.8699973 1.06833419 0.095363013 0.831280302 1 4.895613262 5.455444722 51053 geminin DNA replication inhibitor "GO:0000082,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006275,GO:0008156,GO:0009887,GO:0035563,GO:0042826,GO:0045786,GO:0045892,GO:0070491,GO:0071163,GO:2000104" "G1/S transition of mitotic cell cycle|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA replication|negative regulation of DNA replication|animal organ morphogenesis|positive regulation of chromatin binding|histone deacetylase binding|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|repressing transcription factor binding|DNA replication preinitiation complex assembly|negative regulation of DNA-dependent DNA replication" GMPPA 636.8366195 765.2768002 508.3964389 0.664330134 -0.590027739 0.126325031 1 25.46555203 17.64627232 29926 GDP-mannose pyrophosphorylase A "GO:0005515,GO:0005737,GO:0009058,GO:0016779,GO:0070062" protein binding|cytoplasm|biosynthetic process|nucleotidyltransferase activity|extracellular exosome "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GMPPB 1241.781798 1404.69906 1078.864536 0.768039623 -0.380747354 0.263274636 1 22.05986106 17.67267651 29925 GDP-mannose pyrophosphorylase B "GO:0004475,GO:0005515,GO:0005525,GO:0005737,GO:0009298" mannose-1-phosphate guanylyltransferase activity|protein binding|GTP binding|cytoplasm|GDP-mannose biosynthetic process "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GMPR 205.0050221 240.5445645 169.4654796 0.704507624 -0.505312775 0.345599608 1 7.379002787 5.422496764 2766 guanosine monophosphate reductase "GO:0003920,GO:0005829,GO:0006144,GO:0006163,GO:0009409,GO:0043101,GO:0046872,GO:0055114,GO:1902560" GMP reductase activity|cytosol|purine nucleobase metabolic process|purine nucleotide metabolic process|response to cold|purine-containing compound salvage|metal ion binding|oxidation-reduction process|GMP reductase complex hsa00230 Purine metabolism GMPR2 1563.596077 1514.314305 1612.87785 1.065087905 0.090972505 0.784106256 1 40.42945564 44.91581417 51292 guanosine monophosphate reductase 2 "GO:0003920,GO:0005515,GO:0005829,GO:0006144,GO:0043101,GO:0046037,GO:0046872,GO:0055114,GO:1902560" GMP reductase activity|protein binding|cytosol|purine nucleobase metabolic process|purine-containing compound salvage|GMP metabolic process|metal ion binding|oxidation-reduction process|GMP reductase complex hsa00230 Purine metabolism GMPS 1802.058274 1718.320454 1885.796093 1.09746473 0.134174575 0.680573516 1 9.680408137 11.08154131 8833 guanine monophosphate synthase "GO:0003921,GO:0003922,GO:0005524,GO:0005829,GO:0006177,GO:0006541,GO:0009113,GO:0009168,GO:0016462" GMP synthase activity|GMP synthase (glutamine-hydrolyzing) activity|ATP binding|cytosol|GMP biosynthetic process|glutamine metabolic process|purine nucleobase biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|pyrophosphatase activity "hsa00230,hsa00983" Purine metabolism|Drug metabolism - other enzymes GNA11 2050.398847 1789.367372 2311.430321 1.291758393 0.369336257 0.251120201 1 21.62891286 29.14284273 2767 G protein subunit alpha 11 "GO:0001501,GO:0001508,GO:0001664,GO:0001750,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005765,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0007188,GO:0007213,GO:0007507,GO:0007603,GO:0009649,GO:0030168,GO:0031683,GO:0031826,GO:0045202,GO:0045634,GO:0046872,GO:0048066,GO:0060158,GO:0070062,GO:0071467" "skeletal system development|action potential|G protein-coupled receptor binding|photoreceptor outer segment|GTPase activity|protein binding|GTP binding|cytoplasm|lysosomal membrane|heterotrimeric G-protein complex|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|heart development|phototransduction, visible light|entrainment of circadian clock|platelet activation|G-protein beta/gamma-subunit complex binding|type 2A serotonin receptor binding|synapse|regulation of melanocyte differentiation|metal ion binding|developmental pigmentation|phospholipase C-activating dopamine receptor signaling pathway|extracellular exosome|cellular response to pH" "hsa04020,hsa04022,hsa04270,hsa04540,hsa04725,hsa04730,hsa04911,hsa04912,hsa04925,hsa04927,hsa04928,hsa04929,hsa04934,hsa04935,hsa05142,hsa05146,hsa05163,hsa05170,hsa05200" "Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Cholinergic synapse|Long-term depression|Insulin secretion|GnRH signaling pathway|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Chagas disease|Amoebiasis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer" GNA12 4242.834621 4195.827973 4289.84127 1.022406375 0.031968738 0.920925039 1 39.72035231 42.35967024 2768 G protein subunit alpha 12 "GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005834,GO:0005886,GO:0005925,GO:0007186,GO:0007188,GO:0007266,GO:0007596,GO:0010762,GO:0016328,GO:0030168,GO:0031526,GO:0031683,GO:0031752,GO:0032006,GO:0032434,GO:0042493,GO:0046872" G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|cytoplasm|heterotrimeric G-protein complex|plasma membrane|focal adhesion|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|Rho protein signal transduction|blood coagulation|regulation of fibroblast migration|lateral plasma membrane|platelet activation|brush border membrane|G-protein beta/gamma-subunit complex binding|D5 dopamine receptor binding|regulation of TOR signaling|regulation of proteasomal ubiquitin-dependent protein catabolic process|response to drug|metal ion binding "hsa04010,hsa04022,hsa04071,hsa04072,hsa04270,hsa04730,hsa04810,hsa04928,hsa05130,hsa05163,hsa05200" "MAPK signaling pathway|cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Vascular smooth muscle contraction|Long-term depression|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Pathogenic Escherichia coli infection|Human cytomegalovirus infection|Pathways in cancer" GNA13 2236.875356 2245.082602 2228.66811 0.992688691 -0.010586737 0.975158649 1 15.91177073 16.47583813 10672 G protein subunit alpha 13 "GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005834,GO:0005886,GO:0005925,GO:0007165,GO:0007186,GO:0007188,GO:0007189,GO:0007204,GO:0007266,GO:0016020,GO:0030168,GO:0031526,GO:0031584,GO:0031683,GO:0031752,GO:0042470,GO:0043065,GO:0046872,GO:0051056,GO:0070062" G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|heterotrimeric G-protein complex|plasma membrane|focal adhesion|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|Rho protein signal transduction|membrane|platelet activation|brush border membrane|activation of phospholipase D activity|G-protein beta/gamma-subunit complex binding|D5 dopamine receptor binding|melanosome|positive regulation of apoptotic process|metal ion binding|regulation of small GTPase mediated signal transduction|extracellular exosome "hsa04022,hsa04071,hsa04072,hsa04270,hsa04371,hsa04611,hsa04730,hsa04810,hsa04928,hsa05130,hsa05163,hsa05200" "cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Platelet activation|Long-term depression|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Pathogenic Escherichia coli infection|Human cytomegalovirus infection|Pathways in cancer" GNA15 869.305082 694.2298824 1044.380282 1.50437241 0.589161753 0.103507289 1 15.46867332 24.27305039 2769 G protein subunit alpha 15 "GO:0001508,GO:0001664,GO:0003924,GO:0005525,GO:0005834,GO:0005886,GO:0007186,GO:0007188,GO:0007202,GO:0007207,GO:0030168,GO:0031683,GO:0031826,GO:0045202,GO:0046872,GO:0051482,GO:0060158" action potential|G protein-coupled receptor binding|GTPase activity|GTP binding|heterotrimeric G-protein complex|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway|platelet activation|G-protein beta/gamma-subunit complex binding|type 2A serotonin receptor binding|synapse|metal ion binding|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|phospholipase C-activating dopamine receptor signaling pathway "hsa04020,hsa04926,hsa05142,hsa05146" Calcium signaling pathway|Relaxin signaling pathway|Chagas disease|Amoebiasis GNAI1 525.1847821 440.4908903 609.8786738 1.384543216 0.469410086 0.245095994 1 2.150916856 3.106319112 2770 G protein subunit alpha i1 "GO:0000287,GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005765,GO:0005813,GO:0005834,GO:0005886,GO:0006457,GO:0007049,GO:0007186,GO:0007188,GO:0007193,GO:0019003,GO:0030496,GO:0031683,GO:0031821,GO:0032794,GO:0043434,GO:0043949,GO:0045121,GO:0050805,GO:0051301,GO:0060236,GO:0070062,GO:0099738,GO:1904322,GO:1904778" magnesium ion binding|G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|lysosomal membrane|centrosome|heterotrimeric G-protein complex|plasma membrane|protein folding|cell cycle|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|GDP binding|midbody|G-protein beta/gamma-subunit complex binding|G protein-coupled serotonin receptor binding|GTPase activating protein binding|response to peptide hormone|regulation of cAMP-mediated signaling|membrane raft|negative regulation of synaptic transmission|cell division|regulation of mitotic spindle organization|extracellular exosome|cell cortex region|cellular response to forskolin|positive regulation of protein localization to cell cortex "hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04261,hsa04360,hsa04371,hsa04540,hsa04611,hsa04670,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04914,hsa04915,hsa04916,hsa04921,hsa04923,hsa04924,hsa04926,hsa04928,hsa04934,hsa04935,hsa04971,hsa05012,hsa05030,hsa05032,hsa05034,hsa05133,hsa05142,hsa05145,hsa05163,hsa05170,hsa05200" "Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Axon guidance|Apelin signaling pathway|Gap junction|Platelet activation|Leukocyte transendothelial migration|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Gastric acid secretion|Parkinson disease|Cocaine addiction|Morphine addiction|Alcoholism|Pertussis|Chagas disease|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer" GNAI2 11987.73422 11486.25669 12489.21174 1.087317834 0.120773716 0.724135362 1 187.8393221 213.0389206 2771 G protein subunit alpha i2 "GO:0001664,GO:0001973,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005834,GO:0005886,GO:0006457,GO:0007049,GO:0007165,GO:0007186,GO:0007188,GO:0007189,GO:0007193,GO:0007194,GO:0007213,GO:0007214,GO:0007584,GO:0008283,GO:0008284,GO:0016020,GO:0030335,GO:0030425,GO:0030496,GO:0031683,GO:0032930,GO:0033864,GO:0035810,GO:0035815,GO:0044297,GO:0045121,GO:0045202,GO:0045955,GO:0046628,GO:0046872,GO:0050805,GO:0051301,GO:0051924,GO:0070062,GO:0070374,GO:0140199,GO:1903561,GO:1903614,GO:1904707,GO:2000179,GO:2001234" G protein-coupled receptor binding|G protein-coupled adenosine receptor signaling pathway|GTPase activity|protein binding|GTP binding|nucleoplasm|cytoplasm|centrosome|cytosol|heterotrimeric G-protein complex|plasma membrane|protein folding|cell cycle|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|G protein-coupled acetylcholine receptor signaling pathway|gamma-aminobutyric acid signaling pathway|response to nutrient|cell population proliferation|positive regulation of cell population proliferation|membrane|positive regulation of cell migration|dendrite|midbody|G-protein beta/gamma-subunit complex binding|positive regulation of superoxide anion generation|positive regulation of NAD(P)H oxidase activity|positive regulation of urine volume|positive regulation of renal sodium excretion|cell body|membrane raft|synapse|negative regulation of calcium ion-dependent exocytosis|positive regulation of insulin receptor signaling pathway|metal ion binding|negative regulation of synaptic transmission|cell division|regulation of calcium ion transport|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|extracellular vesicle|negative regulation of protein tyrosine phosphatase activity|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of neural precursor cell proliferation|negative regulation of apoptotic signaling pathway "hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04261,hsa04360,hsa04371,hsa04540,hsa04611,hsa04670,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04914,hsa04915,hsa04916,hsa04921,hsa04923,hsa04924,hsa04926,hsa04928,hsa04934,hsa04935,hsa04971,hsa05012,hsa05030,hsa05032,hsa05034,hsa05133,hsa05142,hsa05145,hsa05163,hsa05170,hsa05200" "Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Axon guidance|Apelin signaling pathway|Gap junction|Platelet activation|Leukocyte transendothelial migration|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Gastric acid secretion|Parkinson disease|Cocaine addiction|Morphine addiction|Alcoholism|Pertussis|Chagas disease|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer" GNAI3 2658.415617 2840.861755 2475.969479 0.871555778 -0.198335097 0.533924153 1 15.90884851 14.46271615 2773 G protein subunit alpha i3 "GO:0000139,GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005765,GO:0005789,GO:0005813,GO:0005834,GO:0005886,GO:0006457,GO:0006906,GO:0007049,GO:0007186,GO:0007188,GO:0007193,GO:0007194,GO:0007212,GO:0007420,GO:0016020,GO:0016239,GO:0019003,GO:0019904,GO:0030496,GO:0031683,GO:0031821,GO:0032794,GO:0032930,GO:0033864,GO:0042588,GO:0045121,GO:0046039,GO:0046872,GO:0051301,GO:0070062,GO:1904707,GO:2001234" Golgi membrane|G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|cytoplasm|lysosomal membrane|endoplasmic reticulum membrane|centrosome|heterotrimeric G-protein complex|plasma membrane|protein folding|vesicle fusion|cell cycle|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|dopamine receptor signaling pathway|brain development|membrane|positive regulation of macroautophagy|GDP binding|protein domain specific binding|midbody|G-protein beta/gamma-subunit complex binding|G protein-coupled serotonin receptor binding|GTPase activating protein binding|positive regulation of superoxide anion generation|positive regulation of NAD(P)H oxidase activity|zymogen granule|membrane raft|GTP metabolic process|metal ion binding|cell division|extracellular exosome|positive regulation of vascular associated smooth muscle cell proliferation|negative regulation of apoptotic signaling pathway "hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04261,hsa04360,hsa04371,hsa04540,hsa04611,hsa04670,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04914,hsa04915,hsa04916,hsa04921,hsa04923,hsa04924,hsa04926,hsa04928,hsa04934,hsa04935,hsa04971,hsa05012,hsa05030,hsa05032,hsa05034,hsa05133,hsa05142,hsa05145,hsa05163,hsa05170,hsa05200" "Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Axon guidance|Apelin signaling pathway|Gap junction|Platelet activation|Leukocyte transendothelial migration|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Gastric acid secretion|Parkinson disease|Cocaine addiction|Morphine addiction|Alcoholism|Pertussis|Chagas disease|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer" GNAL 503.5859154 412.0721232 595.0997076 1.444163956 0.530234541 0.193857829 1 2.583560205 3.891804516 2774 G protein subunit alpha L "GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005834,GO:0005886,GO:0007165,GO:0007188,GO:0007189,GO:0007191,GO:0007193,GO:0007606,GO:0031683,GO:0046872,GO:0070062" G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|sensory perception of chemical stimulus|G-protein beta/gamma-subunit complex binding|metal ion binding|extracellular exosome "hsa04020,hsa04728,hsa04740,hsa05012,hsa05142,hsa05146" Calcium signaling pathway|Dopaminergic synapse|Olfactory transduction|Parkinson disease|Chagas disease|Amoebiasis GNAO1 17.03156482 19.2841634 14.77896625 0.766378398 -0.383871199 0.780742428 1 0.122543895 0.097960471 2775 G protein subunit alpha o1 "GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005834,GO:0005886,GO:0006457,GO:0006936,GO:0007188,GO:0007212,GO:0007223,GO:0007568,GO:0007626,GO:0008016,GO:0030425,GO:0030900,GO:0031175,GO:0031683,GO:0031821,GO:0031852,GO:0032794,GO:0034097,GO:0042475,GO:0042493,GO:0042542,GO:0043209,GO:0043278,GO:0043547,GO:0044297,GO:0046872,GO:0051430,GO:0051926" "G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|heterotrimeric G-protein complex|plasma membrane|protein folding|muscle contraction|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|aging|locomotory behavior|regulation of heart contraction|dendrite|forebrain development|neuron projection development|G-protein beta/gamma-subunit complex binding|G protein-coupled serotonin receptor binding|mu-type opioid receptor binding|GTPase activating protein binding|response to cytokine|odontogenesis of dentin-containing tooth|response to drug|response to hydrogen peroxide|myelin sheath|response to morphine|positive regulation of GTPase activity|cell body|metal ion binding|corticotropin-releasing hormone receptor 1 binding|negative regulation of calcium ion transport" "hsa04015,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04915,hsa04916,hsa04921,hsa04926,hsa05032,hsa05034,hsa05142,hsa05145,hsa05163,hsa05170" Rap1 signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Relaxin signaling pathway|Morphine addiction|Alcoholism|Chagas disease|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection GNAQ 1688.407454 1559.987323 1816.827584 1.164642531 0.219887209 0.501798828 1 11.35007249 13.78818846 2776 G protein subunit alpha q "GO:0001508,GO:0001664,GO:0001750,GO:0003924,GO:0005096,GO:0005515,GO:0005525,GO:0005737,GO:0005765,GO:0005794,GO:0005834,GO:0005886,GO:0006469,GO:0007186,GO:0007188,GO:0007189,GO:0007202,GO:0007213,GO:0007215,GO:0007596,GO:0007603,GO:0009649,GO:0030168,GO:0031683,GO:0031826,GO:0031965,GO:0043547,GO:0045202,GO:0046872,GO:0050821,GO:0060828,GO:0070062" "action potential|G protein-coupled receptor binding|photoreceptor outer segment|GTPase activity|GTPase activator activity|protein binding|GTP binding|cytoplasm|lysosomal membrane|Golgi apparatus|heterotrimeric G-protein complex|plasma membrane|negative regulation of protein kinase activity|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|G protein-coupled acetylcholine receptor signaling pathway|glutamate receptor signaling pathway|blood coagulation|phototransduction, visible light|entrainment of circadian clock|platelet activation|G-protein beta/gamma-subunit complex binding|type 2A serotonin receptor binding|nuclear membrane|positive regulation of GTPase activity|synapse|metal ion binding|protein stabilization|regulation of canonical Wnt signaling pathway|extracellular exosome" "hsa04015,hsa04020,hsa04022,hsa04062,hsa04071,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04929,hsa04934,hsa04935,hsa04961,hsa04970,hsa04971,hsa04972,hsa05010,hsa05016,hsa05017,hsa05022,hsa05135,hsa05142,hsa05143,hsa05146,hsa05163,hsa05170,hsa05200" "Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Yersinia infection|Chagas disease|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer" GNAS 31322.30341 32686.65696 29957.94985 0.916519236 -0.125762935 0.748456386 1 234.7842666 224.4535633 2778 GNAS complex locus "GO:0001664,GO:0001894,GO:0001958,GO:0003924,GO:0005159,GO:0005515,GO:0005525,GO:0005829,GO:0005834,GO:0006112,GO:0006306,GO:0007188,GO:0007189,GO:0007191,GO:0007606,GO:0010856,GO:0016020,GO:0016324,GO:0030425,GO:0031683,GO:0031698,GO:0031748,GO:0031852,GO:0035116,GO:0035255,GO:0035264,GO:0040032,GO:0042493,GO:0043588,GO:0045669,GO:0045672,GO:0046872,GO:0048589,GO:0048701,GO:0050790,GO:0051216,GO:0051430,GO:0060348,GO:0070062,GO:0070527,GO:0071514,GO:0120162,GO:2000828" G protein-coupled receptor binding|tissue homeostasis|endochondral ossification|GTPase activity|insulin-like growth factor receptor binding|protein binding|GTP binding|cytosol|heterotrimeric G-protein complex|energy reserve metabolic process|DNA methylation|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|sensory perception of chemical stimulus|adenylate cyclase activator activity|membrane|apical plasma membrane|dendrite|G-protein beta/gamma-subunit complex binding|beta-2 adrenergic receptor binding|D1 dopamine receptor binding|mu-type opioid receptor binding|embryonic hindlimb morphogenesis|ionotropic glutamate receptor binding|multicellular organism growth|post-embryonic body morphogenesis|response to drug|skin development|positive regulation of osteoblast differentiation|positive regulation of osteoclast differentiation|metal ion binding|developmental growth|embryonic cranial skeleton morphogenesis|regulation of catalytic activity|cartilage development|corticotropin-releasing hormone receptor 1 binding|bone development|extracellular exosome|platelet aggregation|genetic imprinting|positive regulation of cold-induced thermogenesis|regulation of parathyroid hormone secretion "hsa01522,hsa04015,hsa04020,hsa04024,hsa04072,hsa04261,hsa04270,hsa04540,hsa04611,hsa04713,hsa04714,hsa04724,hsa04726,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04913,hsa04915,hsa04916,hsa04918,hsa04921,hsa04922,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04961,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05012,hsa05030,hsa05031,hsa05032,hsa05034,hsa05110,hsa05142,hsa05146,hsa05163,hsa05165,hsa05200,hsa05414" "Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Glutamatergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Parkinson disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Vibrio cholerae infection|Chagas disease|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Dilated cardiomyopathy" GNAT2 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.153353041 0.062111771 2780 G protein subunit alpha transducin 2 "GO:0001580,GO:0001664,GO:0001750,GO:0001917,GO:0003924,GO:0005525,GO:0005834,GO:0005886,GO:0006457,GO:0007186,GO:0007188,GO:0007223,GO:0007601,GO:0007602,GO:0008020,GO:0031683,GO:0042622,GO:0046872,GO:0050908" "detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor binding|photoreceptor outer segment|photoreceptor inner segment|GTPase activity|GTP binding|heterotrimeric G-protein complex|plasma membrane|protein folding|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|visual perception|phototransduction|G protein-coupled photoreceptor activity|G-protein beta/gamma-subunit complex binding|photoreceptor outer segment membrane|metal ion binding|detection of light stimulus involved in visual perception" hsa04744 Phototransduction GNAZ 160.797776 114.6900244 206.9055275 1.804041184 0.851232274 0.142397171 1 0.301779153 0.567873513 2781 G protein subunit alpha z "GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005635,GO:0005783,GO:0005829,GO:0005834,GO:0005886,GO:0006457,GO:0007186,GO:0007188,GO:0007193,GO:0031683,GO:0031821,GO:0046872" G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|nuclear envelope|endoplasmic reticulum|cytosol|heterotrimeric G-protein complex|plasma membrane|protein folding|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|G-protein beta/gamma-subunit complex binding|G protein-coupled serotonin receptor binding|metal ion binding hsa04730 Long-term depression GNB1 14158.55356 13896.77712 14420.33 1.03767441 0.053353842 0.878327929 1 215.8303392 233.6089782 2782 G protein subunit beta 1 "GO:0001917,GO:0003924,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0005834,GO:0005886,GO:0006457,GO:0007165,GO:0007186,GO:0007191,GO:0007200,GO:0007204,GO:0007213,GO:0007223,GO:0007265,GO:0008283,GO:0010659,GO:0016020,GO:0016056,GO:0030168,GO:0030425,GO:0030507,GO:0031682,GO:0042622,GO:0044297,GO:0044877,GO:0045202,GO:0047391,GO:0050909,GO:0051020,GO:0060041,GO:0070062,GO:0071380,GO:0071456,GO:0071870,GO:0097381,GO:1903561" "photoreceptor inner segment|GTPase activity|protein binding|cytoplasm|lysosomal membrane|cytosol|heterotrimeric G-protein complex|plasma membrane|protein folding|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|G protein-coupled acetylcholine receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|Ras protein signal transduction|cell population proliferation|cardiac muscle cell apoptotic process|membrane|rhodopsin mediated signaling pathway|platelet activation|dendrite|spectrin binding|G-protein gamma-subunit binding|photoreceptor outer segment membrane|cell body|protein-containing complex binding|synapse|alkylglycerophosphoethanolamine phosphodiesterase activity|sensory perception of taste|GTPase binding|retina development in camera-type eye|extracellular exosome|cellular response to prostaglandin E stimulus|cellular response to hypoxia|cellular response to catecholamine stimulus|photoreceptor disc membrane|extracellular vesicle" "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04744,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Phototransduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB1L 109.145623 119.7648043 98.52644165 0.822666077 -0.281621141 0.676758382 1 0.913228671 0.78364444 54584 G protein subunit beta 1 like "GO:0003674,GO:0007186,GO:0009898,GO:0035556" molecular_function|G protein-coupled receptor signaling pathway|cytoplasmic side of plasma membrane|intracellular signal transduction GNB2 4766.222819 4883.96812 4648.477517 0.951782936 -0.071295505 0.824390444 1 148.6512955 147.5783133 2783 G protein subunit beta 2 "GO:0003924,GO:0005246,GO:0005515,GO:0005615,GO:0005737,GO:0005765,GO:0005829,GO:0005834,GO:0005886,GO:0005925,GO:0006457,GO:0007186,GO:0016020,GO:0031682,GO:0031982,GO:0044297,GO:0044877,GO:0048471,GO:0051020,GO:0070062" GTPase activity|calcium channel regulator activity|protein binding|extracellular space|cytoplasm|lysosomal membrane|cytosol|heterotrimeric G-protein complex|plasma membrane|focal adhesion|protein folding|G protein-coupled receptor signaling pathway|membrane|G-protein gamma-subunit binding|vesicle|cell body|protein-containing complex binding|perinuclear region of cytoplasm|GTPase binding|extracellular exosome "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB3 85.62076477 94.39090506 76.85062449 0.81417404 -0.296590873 0.687244205 1 2.885073235 2.450135045 2784 G protein subunit beta 3 "GO:0003924,GO:0005515,GO:0005737,GO:0005829,GO:0005834,GO:0005886,GO:0006457,GO:0006884,GO:0007186,GO:0008217,GO:0010468,GO:0010906,GO:0030425,GO:0030507,GO:0031682,GO:0032350,GO:0044297,GO:0045598,GO:0051020,GO:0060259,GO:0070062,GO:0090181,GO:0090207,GO:0090325,GO:1903725" GTPase activity|protein binding|cytoplasm|cytosol|heterotrimeric G-protein complex|plasma membrane|protein folding|cell volume homeostasis|G protein-coupled receptor signaling pathway|regulation of blood pressure|regulation of gene expression|regulation of glucose metabolic process|dendrite|spectrin binding|G-protein gamma-subunit binding|regulation of hormone metabolic process|cell body|regulation of fat cell differentiation|GTPase binding|regulation of feeding behavior|extracellular exosome|regulation of cholesterol metabolic process|regulation of triglyceride metabolic process|regulation of locomotion involved in locomotory behavior|regulation of phospholipid metabolic process "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04742,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Taste transduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB4 1743.553807 1726.440102 1760.667512 1.019825426 0.028322212 0.932560419 1 13.16244177 14.0016181 59345 G protein subunit beta 4 "GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0005834,GO:0006457,GO:0007186,GO:0021762,GO:0031682,GO:0044877,GO:0070062" protein binding|cytoplasm|lysosomal membrane|cytosol|heterotrimeric G-protein complex|protein folding|G protein-coupled receptor signaling pathway|substantia nigra development|G-protein gamma-subunit binding|protein-containing complex binding|extracellular exosome "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB5 859.9868857 730.7682972 989.2054742 1.353651326 0.436856176 0.227952911 1 3.166296198 4.470687173 10681 G protein subunit beta 5 "GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005834,GO:0006457,GO:0007165,GO:0007186,GO:0007212,GO:0031682,GO:0043547,GO:0051087,GO:0098793,GO:1901386,GO:1902773" GTPase activity|GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|heterotrimeric G-protein complex|protein folding|signal transduction|G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|G-protein gamma-subunit binding|positive regulation of GTPase activity|chaperone binding|presynapse|negative regulation of voltage-gated calcium channel activity|GTPase activator complex "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNE 2109.208148 2071.525131 2146.891164 1.036381906 0.051555733 0.873772 1 19.25053945 20.81031509 10020 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase "GO:0004553,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006045,GO:0006047,GO:0006054,GO:0007155,GO:0008761,GO:0009384,GO:0046835,GO:0046872" "hydrolase activity, hydrolyzing O-glycosyl compounds|protein binding|ATP binding|cytoplasm|cytosol|N-acetylglucosamine biosynthetic process|UDP-N-acetylglucosamine metabolic process|N-acetylneuraminate metabolic process|cell adhesion|UDP-N-acetylglucosamine 2-epimerase activity|N-acylmannosamine kinase activity|carbohydrate phosphorylation|metal ion binding" hsa00520 Amino sugar and nucleotide sugar metabolism GNG10 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.171203794 0.086677209 2790 G protein subunit gamma 10 "GO:0003924,GO:0005515,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0031680,GO:0031681" GTPase activity|protein binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG11 3370.127381 2932.207793 3808.04697 1.29869615 0.377063929 0.236078469 1 49.19045395 66.63529322 2791 G protein subunit gamma 11 "GO:0003924,GO:0005515,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0031680,GO:0031681" GTPase activity|protein binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG12 3629.809135 3239.739451 4019.87882 1.24080312 0.311274219 0.328162832 1 34.40582388 44.52980246 55970 G protein subunit gamma 12 "GO:0005515,GO:0005834,GO:0005884,GO:0005886,GO:0007165,GO:0007186,GO:0021987,GO:0030165,GO:0031680,GO:0031681,GO:0032496,GO:0042301,GO:0070062" protein binding|heterotrimeric G-protein complex|actin filament|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|cerebral cortex development|PDZ domain binding|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|response to lipopolysaccharide|phosphate ion binding|extracellular exosome "hsa04010,hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04810,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Regulation of actin cytoskeleton|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG2 134.4061992 95.40586103 173.4065373 1.817566924 0.862008486 0.161592985 1 0.907753201 1.720973288 54331 G protein subunit gamma 2 "GO:0005515,GO:0005834,GO:0005886,GO:0006457,GO:0007186,GO:0007191,GO:0007223,GO:0016020,GO:0030168,GO:0031680,GO:0031681,GO:0070062,GO:0071380,GO:0071870" "protein binding|heterotrimeric G-protein complex|plasma membrane|protein folding|G protein-coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|membrane|platelet activation|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|extracellular exosome|cellular response to prostaglandin E stimulus|cellular response to catecholamine stimulus" "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG4 264.7444097 283.1727152 246.3161041 0.86984406 -0.201171308 0.687194143 1 2.831529921 2.569085079 2786 G protein subunit gamma 4 "GO:0005515,GO:0005834,GO:0005886,GO:0007186,GO:0008277,GO:0030308,GO:0031680,GO:0031681,GO:0070062" protein binding|heterotrimeric G-protein complex|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of cell growth|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|extracellular exosome "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG5 1840.181227 1765.008429 1915.354026 1.085181234 0.117936005 0.717137888 1 110.9075066 125.5391393 2787 G protein subunit gamma 5 "GO:0003924,GO:0005515,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0016020,GO:0030165,GO:0031680,GO:0031681,GO:0070062" GTPase activity|protein binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|membrane|PDZ domain binding|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|extracellular exosome "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNGT1 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.233300783 0.078743818 2792 G protein subunit gamma transducin 1 "GO:0001917,GO:0003924,GO:0005515,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0008104,GO:0010659,GO:0016056,GO:0031680,GO:0031681,GO:0042462,GO:0071456,GO:0097381" photoreceptor inner segment|GTPase activity|protein binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|protein localization|cardiac muscle cell apoptotic process|rhodopsin mediated signaling pathway|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|eye photoreceptor cell development|cellular response to hypoxia|photoreceptor disc membrane "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04744,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Phototransduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNL1 2020.476451 1865.48907 2175.463832 1.166162733 0.221769124 0.491335107 1 12.83352898 15.61065709 2794 G protein nucleolar 1 (putative) "GO:0002456,GO:0003924,GO:0005198,GO:0005525,GO:0005615,GO:0005634,GO:0006974,GO:0007165" T cell mediated immunity|GTPase activity|structural molecule activity|GTP binding|extracellular space|nucleus|cellular response to DNA damage stimulus|signal transduction GNL2 859.5427502 868.8023089 850.2831915 0.978684314 -0.031084518 0.934931214 1 15.4772325 15.79980998 29889 G protein nucleolar 2 "GO:0003723,GO:0003924,GO:0005525,GO:0005634,GO:0005730,GO:0008150,GO:0016020,GO:0042254" RNA binding|GTPase activity|GTP binding|nucleus|nucleolus|biological_process|membrane|ribosome biogenesis hsa03008 Ribosome biogenesis in eukaryotes GNL3 1650.749916 1848.234818 1453.265014 0.786298905 -0.346850249 0.290200019 1 45.77338551 37.54193348 26354 G protein nucleolar 3 "GO:0003723,GO:0005515,GO:0005525,GO:0005615,GO:0005634,GO:0005694,GO:0005730,GO:0008283,GO:0016020,GO:0016604,GO:0017145,GO:0019827,GO:0030496,GO:0032206,GO:0033235,GO:0042127,GO:0048027,GO:1902895,GO:1904816" "RNA binding|protein binding|GTP binding|extracellular space|nucleus|chromosome|nucleolus|cell population proliferation|membrane|nuclear body|stem cell division|stem cell population maintenance|midbody|positive regulation of telomere maintenance|positive regulation of protein sumoylation|regulation of cell population proliferation|mRNA 5'-UTR binding|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of protein localization to chromosome, telomeric region" hsa03008 Ribosome biogenesis in eukaryotes GNL3L 1120.387918 1188.513439 1052.262397 0.885360117 -0.17566371 0.612480729 1 7.026265071 6.488740614 54552 G protein nucleolar 3 like "GO:0003723,GO:0005515,GO:0005525,GO:0005654,GO:0005697,GO:0005730,GO:0005829,GO:0016020,GO:0031334,GO:0031397,GO:0031647,GO:0032091,GO:0032211,GO:0033234,GO:0042254,GO:1904816" "RNA binding|protein binding|GTP binding|nucleoplasm|telomerase holoenzyme complex|nucleolus|cytosol|membrane|positive regulation of protein-containing complex assembly|negative regulation of protein ubiquitination|regulation of protein stability|negative regulation of protein binding|negative regulation of telomere maintenance via telomerase|negative regulation of protein sumoylation|ribosome biogenesis|positive regulation of protein localization to chromosome, telomeric region" hsa03008 Ribosome biogenesis in eukaryotes GNPAT 1038.669117 1024.090572 1053.247661 1.028471202 0.040501397 0.910609639 1 20.28415123 21.76030133 8443 glyceronephosphate O-acyltransferase "GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006625,GO:0006631,GO:0006654,GO:0007416,GO:0007584,GO:0008611,GO:0008654,GO:0016020,GO:0016287,GO:0021587,GO:0030913,GO:0031966,GO:0042493,GO:0042594,GO:0061024,GO:0070542" peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid metabolic process|phosphatidic acid biosynthetic process|synapse assembly|response to nutrient|ether lipid biosynthetic process|phospholipid biosynthetic process|membrane|glycerone-phosphate O-acyltransferase activity|cerebellum morphogenesis|paranodal junction assembly|mitochondrial membrane|response to drug|response to starvation|membrane organization|response to fatty acid "hsa00564,hsa04146" Glycerophospholipid metabolism|Peroxisome GNPDA1 1582.336144 1818.801095 1345.871193 0.739977118 -0.434447435 0.187409427 1 34.93206641 26.9623969 10007 glucosamine-6-phosphate deaminase 1 "GO:0004342,GO:0005515,GO:0005737,GO:0005829,GO:0005975,GO:0006043,GO:0006046,GO:0006048,GO:0006091,GO:0007338,GO:0019262,GO:0042802,GO:0070062" glucosamine-6-phosphate deaminase activity|protein binding|cytoplasm|cytosol|carbohydrate metabolic process|glucosamine catabolic process|N-acetylglucosamine catabolic process|UDP-N-acetylglucosamine biosynthetic process|generation of precursor metabolites and energy|single fertilization|N-acetylneuraminate catabolic process|identical protein binding|extracellular exosome hsa00520 Amino sugar and nucleotide sugar metabolism GNPDA2 377.759583 364.3691926 391.1499734 1.073499026 0.102320882 0.821471219 1 8.256829615 9.245510735 132789 glucosamine-6-phosphate deaminase 2 "GO:0004342,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005975,GO:0006043,GO:0006046,GO:0006048,GO:0019262,GO:0042802" glucosamine-6-phosphate deaminase activity|protein binding|nucleus|cytoplasm|cytosol|carbohydrate metabolic process|glucosamine catabolic process|N-acetylglucosamine catabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylneuraminate catabolic process|identical protein binding hsa00520 Amino sugar and nucleotide sugar metabolism GNPNAT1 1117.800547 1247.380885 988.2202098 0.792236134 -0.335997591 0.33152686 1 15.28561368 12.63145722 64841 glucosamine-phosphate N-acetyltransferase 1 "GO:0000139,GO:0001889,GO:0004343,GO:0005515,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0006041,GO:0006044,GO:0006048,GO:0008080,GO:0010008,GO:0042802,GO:0048029" Golgi membrane|liver development|glucosamine 6-phosphate N-acetyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|glucosamine metabolic process|N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetyltransferase activity|endosome membrane|identical protein binding|monosaccharide binding hsa00520 Amino sugar and nucleotide sugar metabolism GNPTAB 911.0058675 985.5222453 836.4894896 0.848777888 -0.236541023 0.509933958 1 7.987393985 7.071557767 79158 N-acetylglucosamine-1-phosphate transferase subunits alpha and beta "GO:0000139,GO:0003976,GO:0005509,GO:0005515,GO:0005794,GO:0007040,GO:0016021,GO:0016256,GO:0033299,GO:0046835" Golgi membrane|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|calcium ion binding|protein binding|Golgi apparatus|lysosome organization|integral component of membrane|N-glycan processing to lysosome|secretion of lysosomal enzymes|carbohydrate phosphorylation hsa04142 Lysosome GNPTG 696.2602865 651.6017317 740.9188412 1.137073162 0.185325083 0.625818757 1 23.67383716 28.07844125 84572 N-acetylglucosamine-1-phosphate transferase subunit gamma "GO:0000139,GO:0003976,GO:0005794,GO:0042803,GO:0046835,GO:0070062" Golgi membrane|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|Golgi apparatus|protein homodimerization activity|carbohydrate phosphorylation|extracellular exosome hsa04142 Lysosome GNRH1 8.493513748 8.119647747 8.867379749 1.092089217 0.12709072 1 1 0.819186283 0.933161302 2796 gonadotropin releasing hormone 1 "GO:0000003,GO:0005179,GO:0005183,GO:0005576,GO:0005615,GO:0005739,GO:0005798,GO:0007165,GO:0007186,GO:0007267,GO:0007275,GO:0007565,GO:0007568,GO:0008285,GO:0010468,GO:0030238,GO:0030425,GO:0031530,GO:0031960,GO:0032496,GO:0033087,GO:0033574,GO:0034695,GO:0035864,GO:0043066,GO:0043204,GO:0043679,GO:0044849,GO:0045471,GO:0098556,GO:1990008,GO:1990637,GO:2000354,GO:2001223" reproduction|hormone activity|gonadotropin hormone-releasing hormone activity|extracellular region|extracellular space|mitochondrion|Golgi-associated vesicle|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|multicellular organism development|female pregnancy|aging|negative regulation of cell population proliferation|regulation of gene expression|male sex determination|dendrite|gonadotropin-releasing hormone receptor binding|response to corticosteroid|response to lipopolysaccharide|negative regulation of immature T cell proliferation|response to testosterone|response to prostaglandin E|response to potassium ion|negative regulation of apoptotic process|perikaryon|axon terminus|estrous cycle|response to ethanol|cytoplasmic side of rough endoplasmic reticulum membrane|neurosecretory vesicle|response to prolactin|regulation of ovarian follicle development|negative regulation of neuron migration "hsa04080,hsa04912,hsa04929" Neuroactive ligand-receptor interaction|GnRH signaling pathway|GnRH secretion GNRH2 8.045418867 11.16451565 4.926322083 0.441248168 -1.180337805 0.463589814 1 0.186491864 0.085833878 2797 gonadotropin releasing hormone 2 "GO:0000003,GO:0005179,GO:0005183,GO:0005576,GO:0005615,GO:0007165,GO:0007186,GO:0007275,GO:0031530" reproduction|hormone activity|gonadotropin hormone-releasing hormone activity|extracellular region|extracellular space|signal transduction|G protein-coupled receptor signaling pathway|multicellular organism development|gonadotropin-releasing hormone receptor binding "hsa04080,hsa04912,hsa04929" Neuroactive ligand-receptor interaction|GnRH signaling pathway|GnRH secretion GNS 7947.433048 8001.912855 7892.953241 0.986383304 -0.019779714 0.952649493 1 79.76159359 82.06452587 2799 glucosamine (N-acetyl)-6-sulfatase "GO:0005515,GO:0005539,GO:0005576,GO:0006027,GO:0008449,GO:0008484,GO:0035578,GO:0042340,GO:0043202,GO:0043312,GO:0046872,GO:0070062,GO:1904813" protein binding|glycosaminoglycan binding|extracellular region|glycosaminoglycan catabolic process|N-acetylglucosamine-6-sulfatase activity|sulfuric ester hydrolase activity|azurophil granule lumen|keratan sulfate catabolic process|lysosomal lumen|neutrophil degranulation|metal ion binding|extracellular exosome|ficolin-1-rich granule lumen "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome GOLGA1 311.6820408 427.2964627 196.0676189 0.458856171 -1.123886084 0.016976429 0.570200991 4.058713133 1.942588724 2800 golgin A1 "GO:0000139,GO:0001669,GO:0005515,GO:0005794,GO:0005802,GO:0005829,GO:0048471" Golgi membrane|acrosomal vesicle|protein binding|Golgi apparatus|trans-Golgi network|cytosol|perinuclear region of cytoplasm GOLGA2 2297.45155 2277.561193 2317.341908 1.017466365 0.024981103 0.939136714 1 26.46259226 28.08460863 2801 golgin A2 "GO:0000137,GO:0000139,GO:0000922,GO:0005515,GO:0005794,GO:0005801,GO:0005874,GO:0006486,GO:0006888,GO:0007020,GO:0007030,GO:0007098,GO:0008017,GO:0008356,GO:0010507,GO:0015031,GO:0019901,GO:0019905,GO:0030134,GO:0032091,GO:0032580,GO:0033116,GO:0042802,GO:0045296,GO:0048208,GO:0051225,GO:0051289,GO:0060050,GO:0061676,GO:0072686,GO:0090161,GO:0090166,GO:0090306,GO:0090307,GO:1904668" Golgi cis cisterna|Golgi membrane|spindle pole|protein binding|Golgi apparatus|cis-Golgi network|microtubule|protein glycosylation|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule nucleation|Golgi organization|centrosome cycle|microtubule binding|asymmetric cell division|negative regulation of autophagy|protein transport|protein kinase binding|syntaxin binding|COPII-coated ER to Golgi transport vesicle|negative regulation of protein binding|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|identical protein binding|cadherin binding|COPII vesicle coating|spindle assembly|protein homotetramerization|positive regulation of protein glycosylation|importin-alpha family protein binding|mitotic spindle|Golgi ribbon formation|Golgi disassembly|spindle assembly involved in meiosis|mitotic spindle assembly|positive regulation of ubiquitin protein ligase activity GOLGA3 3660.292703 3606.138556 3714.44685 1.030034424 0.042692554 0.894065418 1 17.32974629 18.61915098 2802 golgin A3 "GO:0000139,GO:0005515,GO:0005654,GO:0005730,GO:0005794,GO:0005829,GO:0006891,GO:0007283,GO:0016020,GO:0017119,GO:0032580,GO:0045296,GO:0090498" Golgi membrane|protein binding|nucleoplasm|nucleolus|Golgi apparatus|cytosol|intra-Golgi vesicle-mediated transport|spermatogenesis|membrane|Golgi transport complex|Golgi cisterna membrane|cadherin binding|extrinsic component of Golgi membrane GOLGA4 2885.649956 2883.489906 2887.810005 1.001498219 0.002159855 0.995829735 1 16.67107208 17.41524707 2803 golgin A4 "GO:0000139,GO:0005515,GO:0005654,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0016192,GO:0043001,GO:0045773,GO:0051020,GO:0070062" Golgi membrane|protein binding|nucleoplasm|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|vesicle-mediated transport|Golgi to plasma membrane protein transport|positive regulation of axon extension|GTPase binding|extracellular exosome GOLGA5 1127.738307 1118.481477 1136.995137 1.016552495 0.023684719 0.948038624 1 19.71706963 20.90682629 9950 golgin A5 "GO:0000139,GO:0000301,GO:0005794,GO:0005801,GO:0007030,GO:0016020,GO:0016021,GO:0030133,GO:0031267,GO:0031985,GO:0042803,GO:0048193" "Golgi membrane|retrograde transport, vesicle recycling within Golgi|Golgi apparatus|cis-Golgi network|Golgi organization|membrane|integral component of membrane|transport vesicle|small GTPase binding|Golgi cisterna|protein homodimerization activity|Golgi vesicle transport" GOLGA6L10 47.60173169 54.80762229 40.39584108 0.737047867 -0.440169779 0.620692029 1 0.623497915 0.479343264 647042 golgin A6 family like 10 GOLGA6L4 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.085673232 0.052049664 643707 golgin A6 family like 4 GOLGA6L9 192.0629727 231.4099608 152.7159846 0.659936954 -0.59959989 0.272855076 1 2.406590996 1.656611473 440295 golgin A6 family like 9 GO:0005515 protein binding GOLGA7 676.6440728 657.6914675 695.5966781 1.057633727 0.080840089 0.835045888 1 16.16978283 17.83837989 51125 golgin A7 "GO:0000139,GO:0002178,GO:0005515,GO:0005576,GO:0005795,GO:0006612,GO:0006893,GO:0018215,GO:0018230,GO:0019706,GO:0031228,GO:0043001,GO:0043312,GO:0050821,GO:0070062,GO:1904724" Golgi membrane|palmitoyltransferase complex|protein binding|extracellular region|Golgi stack|protein targeting to membrane|Golgi to plasma membrane transport|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity|intrinsic component of Golgi membrane|Golgi to plasma membrane protein transport|neutrophil degranulation|protein stabilization|extracellular exosome|tertiary granule lumen GOLGA7B 1238.145329 2065.435396 410.8552617 0.198919445 -2.329743787 7.51E-11 1.13E-07 15.28671874 3.171812037 401647 golgin A7 family member B "GO:0000139,GO:0002178,GO:0005515,GO:0006612,GO:0018215,GO:0018230,GO:0019706,GO:0019899" Golgi membrane|palmitoyltransferase complex|protein binding|protein targeting to membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity|enzyme binding GOLGA8A 411.25313 431.3562866 391.1499734 0.906790942 -0.141158115 0.746777439 1 3.781664217 3.576893975 23015 golgin A8 family member A "GO:0000137,GO:0005794,GO:0005801,GO:0005829,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|Golgi apparatus|cis-Golgi network|cytosol|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8B 816.8552164 779.4861837 854.2242491 1.095881193 0.132091401 0.720153847 1 7.040881994 8.048342863 440270 golgin A8 family member B "GO:0000137,GO:0005794,GO:0005801,GO:0005829,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|Golgi apparatus|cis-Golgi network|cytosol|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8H 39.46723816 37.55337083 41.38110549 1.101927858 0.140029776 0.905216405 1 0.36660481 0.42137353 728498 golgin A8 family member H "GO:0000137,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8J 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.034149769 0.017289375 653073 golgin A8 family member J "GO:0000137,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8K 7.971189988 6.08973581 9.852644165 1.617909951 0.694131313 0.702268135 1 0.059610289 0.1005985 653125 golgin A8 family member K "GO:0000137,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8N 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.009646076 0.039068991 643699 golgin A8 family member N "GO:0000137,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8O 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.028176835 0 728047 golgin A8 family member O "GO:0000137,GO:0005515,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|protein binding|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGB1 3349.23839 2986.000459 3712.476322 1.243293955 0.314167437 0.323423288 1 10.84866494 14.06909131 2804 golgin B1 "GO:0000139,GO:0003723,GO:0005515,GO:0005793,GO:0005794,GO:0005795,GO:0005801,GO:0006355,GO:0006888,GO:0007030,GO:0016020,GO:0016021,GO:0043565,GO:1905793" "Golgi membrane|RNA binding|protein binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|Golgi stack|cis-Golgi network|regulation of transcription, DNA-templated|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|membrane|integral component of membrane|sequence-specific DNA binding|protein localization to pericentriolar material" GOLIM4 1048.991382 1123.556257 974.426508 0.867269887 -0.205447077 0.557548766 1 12.27705734 11.1061742 27333 golgi integral membrane protein 4 "GO:0000139,GO:0005794,GO:0005796,GO:0005801,GO:0010008,GO:0016020,GO:0016021,GO:0030133,GO:0030139,GO:0032580" Golgi membrane|Golgi apparatus|Golgi lumen|cis-Golgi network|endosome membrane|membrane|integral component of membrane|transport vesicle|endocytic vesicle|Golgi cisterna membrane GOLM1 1939.695409 2101.973811 1777.417007 0.845594269 -0.241962496 0.453999477 1 33.57223531 29.61135078 51280 golgi membrane protein 1 "GO:0005515,GO:0005615,GO:0005788,GO:0005794,GO:0005887,GO:0006997,GO:0019216,GO:0043687,GO:0044267" protein binding|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|integral component of plasma membrane|nucleus organization|regulation of lipid metabolic process|post-translational protein modification|cellular protein metabolic process GOLM2 1551.547496 1532.583512 1570.51148 1.024747733 0.035268799 0.916860709 1 19.2844592 20.61295999 113201 golgi membrane protein 2 "GO:0005794,GO:0016021" Golgi apparatus|integral component of membrane GOLPH3 2218.090506 2308.009872 2128.17114 0.922080605 -0.117035223 0.715598312 1 32.85344515 31.59844677 64083 golgi phosphoprotein 3 "GO:0005515,GO:0005739,GO:0005758,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006890,GO:0007030,GO:0009101,GO:0009306,GO:0010467,GO:0010821,GO:0016477,GO:0019899,GO:0030032,GO:0031985,GO:0032008,GO:0032580,GO:0043001,GO:0043066,GO:0043231,GO:0045053,GO:0048194,GO:0050714,GO:0050901,GO:0060352,GO:0070273,GO:0072752,GO:0090161,GO:0090164" "protein binding|mitochondrion|mitochondrial intermembrane space|endosome|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|glycoprotein biosynthetic process|protein secretion|gene expression|regulation of mitochondrion organization|cell migration|enzyme binding|lamellipodium assembly|Golgi cisterna|positive regulation of TOR signaling|Golgi cisterna membrane|Golgi to plasma membrane protein transport|negative regulation of apoptotic process|intracellular membrane-bounded organelle|protein retention in Golgi apparatus|Golgi vesicle budding|positive regulation of protein secretion|leukocyte tethering or rolling|cell adhesion molecule production|phosphatidylinositol-4-phosphate binding|cellular response to rapamycin|Golgi ribbon formation|asymmetric Golgi ribbon formation" GOLPH3L 807.4412646 708.4392659 906.4432632 1.279493256 0.355572543 0.332487559 1 8.618772423 11.50268811 55204 golgi phosphoprotein 3 like "GO:0000139,GO:0005515,GO:0005794,GO:0005802,GO:0005829,GO:0006890,GO:0007030,GO:0031985,GO:0032580,GO:0032588,GO:0043001,GO:0048194,GO:0050714,GO:0070273" "Golgi membrane|protein binding|Golgi apparatus|trans-Golgi network|cytosol|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|Golgi cisterna|Golgi cisterna membrane|trans-Golgi network membrane|Golgi to plasma membrane protein transport|Golgi vesicle budding|positive regulation of protein secretion|phosphatidylinositol-4-phosphate binding" GOLT1A 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.197454312 0.33322448 127845 golgi transport 1A "GO:0000137,GO:0000139,GO:0003674,GO:0005515,GO:0005635,GO:0005783,GO:0005802,GO:0006888,GO:0008150,GO:0015031,GO:0016020,GO:0016021" Golgi cis cisterna|Golgi membrane|molecular_function|protein binding|nuclear envelope|endoplasmic reticulum|trans-Golgi network|endoplasmic reticulum to Golgi vesicle-mediated transport|biological_process|protein transport|membrane|integral component of membrane GOLT1B 1227.434843 1232.156546 1222.713141 0.992335873 -0.011099587 0.976670134 1 18.28967827 18.93131086 51026 golgi transport 1B "GO:0000139,GO:0005515,GO:0005783,GO:0015031,GO:0016020,GO:0016021,GO:0016192,GO:0032991,GO:0043123" Golgi membrane|protein binding|endoplasmic reticulum|protein transport|membrane|integral component of membrane|vesicle-mediated transport|protein-containing complex|positive regulation of I-kappaB kinase/NF-kappaB signaling GON4L 1364.853497 1365.115777 1364.591217 0.999615739 -0.000554478 1 1 7.963406852 8.303246284 54856 gon-4 like "GO:0003712,GO:0003714,GO:0005634,GO:0005654,GO:0006355,GO:0016604,GO:0030183,GO:0045892" "transcription coregulator activity|transcription corepressor activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|nuclear body|B cell differentiation|negative regulation of transcription, DNA-templated" GON7 214.5283376 251.7090802 177.347595 0.704573688 -0.505177495 0.338522852 1 11.33171283 8.327946193 84520 GON7 subunit of KEOPS complex "GO:0000408,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829" EKC/KEOPS complex|protein binding|nucleus|nucleoplasm|nucleolus|cytosol GOPC 931.7342766 887.0715164 976.3970368 1.10069709 0.138417496 0.69983482 1 9.614175669 11.03813754 57120 golgi associated PDZ and coiled-coil motif containing "GO:0000139,GO:0005515,GO:0005737,GO:0005765,GO:0005794,GO:0005886,GO:0006888,GO:0006893,GO:0010360,GO:0014069,GO:0015031,GO:0016020,GO:0030140,GO:0030425,GO:0030660,GO:0032991,GO:0042802,GO:0043004,GO:0044325,GO:0045176,GO:2000009" Golgi membrane|protein binding|cytoplasm|lysosomal membrane|Golgi apparatus|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|negative regulation of anion channel activity|postsynaptic density|protein transport|membrane|trans-Golgi network transport vesicle|dendrite|Golgi-associated vesicle membrane|protein-containing complex|identical protein binding|cytoplasmic sequestering of CFTR protein|ion channel binding|apical protein localization|negative regulation of protein localization to cell surface GORAB 289.5541694 295.3521868 283.756152 0.96073828 -0.057784623 0.911014056 1 5.201163533 5.212205545 92344 "golgin, RAB6 interacting" "GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0031069,GO:1901622,GO:1905515" protein binding|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|hair follicle morphogenesis|positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|non-motile cilium assembly hsa04115 p53 signaling pathway GORASP1 1307.882351 1242.306105 1373.458597 1.1055718 0.144792722 0.669231083 1 15.93274795 18.37357083 64689 golgi reassembly stacking protein 1 "GO:0000139,GO:0005515,GO:0005794,GO:0006487,GO:0006888,GO:0007030,GO:0015031,GO:0033116,GO:0046872,GO:0048208,GO:0050774,GO:0061951,GO:1904668" Golgi membrane|protein binding|Golgi apparatus|protein N-linked glycosylation|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|protein transport|endoplasmic reticulum-Golgi intermediate compartment membrane|metal ion binding|COPII vesicle coating|negative regulation of dendrite morphogenesis|establishment of protein localization to plasma membrane|positive regulation of ubiquitin protein ligase activity GORASP2 2049.75083 2048.181144 2051.320515 1.00153276 0.002209613 0.996255322 1 40.9850452 42.81604103 26003 golgi reassembly stacking protein 2 "GO:0000139,GO:0005515,GO:0005789,GO:0005794,GO:0006996,GO:0007030,GO:0007283,GO:0016020,GO:0030154,GO:0034976,GO:0061951,GO:0070925" Golgi membrane|protein binding|endoplasmic reticulum membrane|Golgi apparatus|organelle organization|Golgi organization|spermatogenesis|membrane|cell differentiation|response to endoplasmic reticulum stress|establishment of protein localization to plasma membrane|organelle assembly GOSR1 460.1964247 510.5228521 409.8699973 0.802843586 -0.316809153 0.448884115 1 14.78340849 12.38002293 9527 golgi SNAP receptor complex member 1 "GO:0000139,GO:0005484,GO:0005794,GO:0005797,GO:0005801,GO:0005829,GO:0006888,GO:0006891,GO:0006906,GO:0015031,GO:0016020,GO:0016021,GO:0030133,GO:0031201,GO:0042147,GO:0048209" "Golgi membrane|SNAP receptor activity|Golgi apparatus|Golgi medial cisterna|cis-Golgi network|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|vesicle fusion|protein transport|membrane|integral component of membrane|transport vesicle|SNARE complex|retrograde transport, endosome to Golgi|regulation of vesicle targeting, to, from or within Golgi" hsa04130 SNARE interactions in vesicular transport GOSR2 898.9181921 933.7594909 864.0768933 0.925374148 -0.1118913 0.757549058 1 6.283766158 6.065314253 9570 golgi SNAP receptor complex member 2 "GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005789,GO:0005794,GO:0005829,GO:0006623,GO:0006888,GO:0006891,GO:0006896,GO:0012507,GO:0016020,GO:0016021,GO:0031201,GO:0031902,GO:0033116,GO:0036498,GO:0042147,GO:0048208,GO:0048280" "Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to vacuole|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi to vacuole transport|ER to Golgi transport vesicle membrane|membrane|integral component of membrane|SNARE complex|late endosome membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|IRE1-mediated unfolded protein response|retrograde transport, endosome to Golgi|COPII vesicle coating|vesicle fusion with Golgi apparatus" hsa04130 SNARE interactions in vesicular transport GOT1 2044.39398 2018.747421 2070.040539 1.025408388 0.036198605 0.911903956 1 51.68980544 55.28632126 2805 glutamic-oxaloacetic transaminase 1 "GO:0004069,GO:0004609,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005829,GO:0006094,GO:0006103,GO:0006107,GO:0006114,GO:0006531,GO:0006532,GO:0006533,GO:0006536,GO:0007219,GO:0008652,GO:0009743,GO:0019550,GO:0019551,GO:0030170,GO:0030511,GO:0031406,GO:0032869,GO:0032966,GO:0035902,GO:0043679,GO:0046686,GO:0047801,GO:0051384,GO:0051481,GO:0051902,GO:0055089,GO:0060290,GO:0070062,GO:0071260,GO:1990267" L-aspartate:2-oxoglutarate aminotransferase activity|phosphatidylserine decarboxylase activity|nucleus|nucleoplasm|cytoplasm|lysosome|cytosol|gluconeogenesis|2-oxoglutarate metabolic process|oxaloacetate metabolic process|glycerol biosynthetic process|aspartate metabolic process|aspartate biosynthetic process|aspartate catabolic process|glutamate metabolic process|Notch signaling pathway|cellular amino acid biosynthetic process|response to carbohydrate|glutamate catabolic process to aspartate|glutamate catabolic process to 2-oxoglutarate|pyridoxal phosphate binding|positive regulation of transforming growth factor beta receptor signaling pathway|carboxylic acid binding|cellular response to insulin stimulus|negative regulation of collagen biosynthetic process|response to immobilization stress|axon terminus|response to cadmium ion|L-cysteine:2-oxoglutarate aminotransferase activity|response to glucocorticoid|negative regulation of cytosolic calcium ion concentration|negative regulation of mitochondrial depolarization|fatty acid homeostasis|transdifferentiation|extracellular exosome|cellular response to mechanical stimulus|response to transition metal nanoparticle "hsa00220,hsa00250,hsa00270,hsa00330,hsa00350,hsa00360,hsa00400" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Cysteine and methionine metabolism|Arginine and proline metabolism|Tyrosine metabolism|Phenylalanine metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis" GOT2 2456.458185 2572.91338 2340.002989 0.909476008 -0.136892515 0.668584283 1 53.82444692 51.0606986 2806 glutamic-oxaloacetic transaminase 2 "GO:0003723,GO:0004069,GO:0005543,GO:0005739,GO:0005743,GO:0005759,GO:0005886,GO:0006094,GO:0006103,GO:0006107,GO:0006531,GO:0006532,GO:0006533,GO:0006536,GO:0007565,GO:0007595,GO:0008652,GO:0009986,GO:0014850,GO:0015908,GO:0016212,GO:0016597,GO:0019470,GO:0019550,GO:0019551,GO:0019899,GO:0030170,GO:0030315,GO:0032868,GO:0032991,GO:0042802,GO:0043204,GO:0043278,GO:0045471,GO:0046487,GO:0070062,GO:0097052" RNA binding|L-aspartate:2-oxoglutarate aminotransferase activity|phospholipid binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|plasma membrane|gluconeogenesis|2-oxoglutarate metabolic process|oxaloacetate metabolic process|aspartate metabolic process|aspartate biosynthetic process|aspartate catabolic process|glutamate metabolic process|female pregnancy|lactation|cellular amino acid biosynthetic process|cell surface|response to muscle activity|fatty acid transport|kynurenine-oxoglutarate transaminase activity|amino acid binding|4-hydroxyproline catabolic process|glutamate catabolic process to aspartate|glutamate catabolic process to 2-oxoglutarate|enzyme binding|pyridoxal phosphate binding|T-tubule|response to insulin|protein-containing complex|identical protein binding|perikaryon|response to morphine|response to ethanol|glyoxylate metabolic process|extracellular exosome|L-kynurenine metabolic process "hsa00220,hsa00250,hsa00270,hsa00330,hsa00350,hsa00360,hsa00400,hsa04975" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Cysteine and methionine metabolism|Arginine and proline metabolism|Tyrosine metabolism|Phenylalanine metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis|Fat digestion and absorption" GP1BB 53.72388065 35.52345889 71.92430241 2.024698738 1.017707261 0.221916178 1 1.876056177 3.962070334 2812 glycoprotein Ib platelet subunit beta "GO:0004888,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007166,GO:0007596,GO:0007597,GO:0030168,GO:0042802" "transmembrane signaling receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|cell surface receptor signaling pathway|blood coagulation|blood coagulation, intrinsic pathway|platelet activation|identical protein binding" "hsa04512,hsa04611,hsa04640" ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage GPAA1 3179.674187 3282.367602 3076.980773 0.937427231 -0.093221391 0.770070555 1 80.93492674 79.13880222 8733 glycosylphosphatidylinositol anchor attachment 1 "GO:0003923,GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005813,GO:0005829,GO:0006508,GO:0006621,GO:0015631,GO:0016020,GO:0016255,GO:0034235,GO:0042765,GO:0065003" GPI-anchor transamidase activity|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|centrosome|cytosol|proteolysis|protein retention in ER lumen|tubulin binding|membrane|attachment of GPI anchor to protein|GPI anchor binding|GPI-anchor transamidase complex|protein-containing complex assembly hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis GPALPP1 376.4301441 374.5187523 378.341536 1.010207189 0.014651213 0.980248128 1 4.063421933 4.281720408 55425 GPALPP motifs containing 1 GPAM 413.2182156 498.3433805 328.0930507 0.65836743 -0.603035128 0.160766321 1 3.768752303 2.588104825 57678 "glycerol-3-phosphate acyltransferase, mitochondrial" "GO:0001817,GO:0004366,GO:0005515,GO:0005741,GO:0005886,GO:0006072,GO:0006631,GO:0006637,GO:0006651,GO:0006654,GO:0006655,GO:0008654,GO:0009749,GO:0016021,GO:0016024,GO:0019432,GO:0031966,GO:0033146,GO:0040018,GO:0042104,GO:0045540,GO:0051607,GO:0055089,GO:0055091,GO:0070236,GO:0102420" regulation of cytokine production|glycerol-3-phosphate O-acyltransferase activity|protein binding|mitochondrial outer membrane|plasma membrane|glycerol-3-phosphate metabolic process|fatty acid metabolic process|acyl-CoA metabolic process|diacylglycerol biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylglycerol biosynthetic process|phospholipid biosynthetic process|response to glucose|integral component of membrane|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|mitochondrial membrane|regulation of intracellular estrogen receptor signaling pathway|positive regulation of multicellular organism growth|positive regulation of activated T cell proliferation|regulation of cholesterol biosynthetic process|defense response to virus|fatty acid homeostasis|phospholipid homeostasis|negative regulation of activation-induced cell death of T cells|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism GPANK1 320.2579482 340.0102494 300.505647 0.883813496 -0.178186134 0.704711526 1 6.052836432 5.580016672 7918 G-patch domain and ankyrin repeats 1 "GO:0003676,GO:0005515" nucleic acid binding|protein binding GPAT3 254.0576804 259.8287279 248.286633 0.955578065 -0.065554358 0.903167964 1 2.499412811 2.491265955 84803 glycerol-3-phosphate acyltransferase 3 "GO:0003841,GO:0004366,GO:0005783,GO:0005789,GO:0006072,GO:0006654,GO:0016021,GO:0016024,GO:0019432,GO:0032006,GO:0102420" 1-acylglycerol-3-phosphate O-acyltransferase activity|glycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|glycerol-3-phosphate metabolic process|phosphatidic acid biosynthetic process|integral component of membrane|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|regulation of TOR signaling|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism GPAT4 2130.974277 2246.097558 2015.850996 0.8974904 -0.156031587 0.627439537 1 17.81348537 16.67610585 137964 glycerol-3-phosphate acyltransferase 4 "GO:0002071,GO:0003841,GO:0004366,GO:0005783,GO:0005789,GO:0006631,GO:0006637,GO:0006654,GO:0006656,GO:0007595,GO:0008610,GO:0016020,GO:0016021,GO:0016024,GO:0019432,GO:0040014,GO:0046339,GO:0102420" glandular epithelial cell maturation|1-acylglycerol-3-phosphate O-acyltransferase activity|glycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|acyl-CoA metabolic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|lactation|lipid biosynthetic process|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|regulation of multicellular organism growth|diacylglycerol metabolic process|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism GPATCH1 153.660671 131.9442759 175.3770661 1.329175252 0.410531337 0.487923039 1 2.085677935 2.891647984 55094 G-patch domain containing 1 "GO:0000398,GO:0003723,GO:0005634,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|nucleus|catalytic step 2 spliceosome" GPATCH11 373.4473809 338.9952934 407.8994685 1.203259975 0.266948384 0.548339275 1 4.369792749 5.484489889 253635 G-patch domain containing 11 "GO:0000776,GO:0000777,GO:0003676,GO:0005515" kinetochore|condensed chromosome kinetochore|nucleic acid binding|protein binding GPATCH2 343.91914 341.0252054 346.8130746 1.016971969 0.024279915 0.964284514 1 1.683567949 1.78589352 55105 G-patch domain containing 2 "GO:0003676,GO:0005730,GO:0010923,GO:0016607" nucleic acid binding|nucleolus|negative regulation of phosphatase activity|nuclear speck GPATCH2L 1731.470337 1439.207563 2023.733112 1.406144022 0.491744368 0.132067828 1 4.100055454 6.01361285 55668 G-patch domain containing 2 like GO:0005515 protein binding GPATCH3 209.1566422 221.2604011 197.0528833 0.890592633 -0.167162416 0.759479029 1 5.273439415 4.898791878 63906 G-patch domain containing 3 "GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0032480,GO:0039536,GO:0045893" "nucleic acid binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|negative regulation of type I interferon production|negative regulation of RIG-I signaling pathway|positive regulation of transcription, DNA-templated" GPATCH4 449.3436703 509.5078961 389.1794445 0.763833981 -0.388668992 0.355313937 1 11.97993385 9.544854765 54865 G-patch domain containing 4 "GO:0003723,GO:0005515" RNA binding|protein binding GPATCH8 2031.719155 2027.882025 2035.556285 1.003784372 0.00544939 0.988218562 1 13.85098727 14.50230684 23131 G-patch domain containing 8 "GO:0003723,GO:0005515,GO:0005575,GO:0005634,GO:0008150,GO:0046872" RNA binding|protein binding|cellular_component|nucleus|biological_process|metal ion binding GPBP1 1723.898499 1662.497876 1785.299123 1.073865506 0.102813317 0.753908872 1 18.33216906 20.53428927 65056 GC-rich promoter binding protein 1 "GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006351,GO:0006355,GO:0043231,GO:0045893" "DNA binding|RNA binding|protein binding|nucleus|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated" GPBP1L1 1917.608116 1838.085259 1997.130972 1.086527931 0.119725261 0.712017982 1 23.99910647 27.19893486 60313 GC-rich promoter binding protein 1 like 1 "GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0006351,GO:0006355,GO:0045893" "DNA binding|RNA binding|protein binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated" GPC1 493.460604 460.7900096 526.1311984 1.141802529 0.191313163 0.643251224 1 5.824154834 6.936491245 2817 glypican 1 "GO:0001523,GO:0005507,GO:0005576,GO:0005615,GO:0005654,GO:0005768,GO:0005796,GO:0005829,GO:0005886,GO:0006024,GO:0006027,GO:0007411,GO:0009986,GO:0014037,GO:0016477,GO:0017134,GO:0030200,GO:0031012,GO:0031226,GO:0032288,GO:0040037,GO:0043202,GO:0043236,GO:0045121,GO:0045202,GO:0046658,GO:0050900,GO:0062023,GO:0070062,GO:1905475,GO:2001016" retinoid metabolic process|copper ion binding|extracellular region|extracellular space|nucleoplasm|endosome|Golgi lumen|cytosol|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|axon guidance|cell surface|Schwann cell differentiation|cell migration|fibroblast growth factor binding|heparan sulfate proteoglycan catabolic process|extracellular matrix|intrinsic component of plasma membrane|myelin assembly|negative regulation of fibroblast growth factor receptor signaling pathway|lysosomal lumen|laminin binding|membrane raft|synapse|anchored component of plasma membrane|leukocyte migration|collagen-containing extracellular matrix|extracellular exosome|regulation of protein localization to membrane|positive regulation of skeletal muscle cell differentiation "hsa05205,hsa05418" Proteoglycans in cancer|Fluid shear stress and atherosclerosis GPC2 25.86925302 17.25425146 34.48425458 1.998594645 0.998985894 0.338410605 1 0.34323133 0.715529548 221914 glypican 2 "GO:0001523,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0007224,GO:0009966,GO:0009986,GO:0010976,GO:0016477,GO:0030182,GO:0043202,GO:0045202,GO:0046658,GO:0062023,GO:1905475" retinoid metabolic process|protein binding|extracellular region|extracellular space|endoplasmic reticulum|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|smoothened signaling pathway|regulation of signal transduction|cell surface|positive regulation of neuron projection development|cell migration|neuron differentiation|lysosomal lumen|synapse|anchored component of plasma membrane|collagen-containing extracellular matrix|regulation of protein localization to membrane GPC4 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.031488 2239 glypican 4 "GO:0001523,GO:0005515,GO:0005576,GO:0005634,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0009897,GO:0009966,GO:0009986,GO:0016055,GO:0016477,GO:0043202,GO:0045202,GO:0060071,GO:0062023,GO:0070062,GO:0098696,GO:0098978,GO:0099026,GO:0099560,GO:1904929,GO:1905475,GO:1905606" "retinoid metabolic process|protein binding|extracellular region|nucleus|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|external side of plasma membrane|regulation of signal transduction|cell surface|Wnt signaling pathway|cell migration|lysosomal lumen|synapse|Wnt signaling pathway, planar cell polarity pathway|collagen-containing extracellular matrix|extracellular exosome|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|glutamatergic synapse|anchored component of presynaptic membrane|synaptic membrane adhesion|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|regulation of protein localization to membrane|regulation of presynapse assembly" hsa04310 Wnt signaling pathway GPC5 13.49406471 13.19442759 13.79370183 1.045418737 0.064080923 1 1 0.069631261 0.075929488 2262 glypican 5 "GO:0001523,GO:0005515,GO:0005576,GO:0005615,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0009986,GO:0016021,GO:0016477,GO:0043202,GO:0046658,GO:0062023,GO:0090263,GO:1905475" retinoid metabolic process|protein binding|extracellular region|extracellular space|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cell surface|integral component of membrane|cell migration|lysosomal lumen|anchored component of plasma membrane|collagen-containing extracellular matrix|positive regulation of canonical Wnt signaling pathway|regulation of protein localization to membrane GPCPD1 415.3668937 510.5228521 320.2109354 0.627221552 -0.672952963 0.117187575 1 3.848791522 2.518032257 56261 glycerophosphocholine phosphodiesterase 1 "GO:0005829,GO:0007519,GO:0046475,GO:0047389,GO:2001070" cytosol|skeletal muscle tissue development|glycerophospholipid catabolic process|glycerophosphocholine phosphodiesterase activity|starch binding "hsa00564,hsa05231" Glycerophospholipid metabolism|Choline metabolism in cancer GPD1L 596.7485804 651.6017317 541.8954291 0.831635956 -0.26597596 0.497959309 1 8.348426258 7.241921335 23171 glycerol-3-phosphate dehydrogenase 1 like "GO:0002027,GO:0004367,GO:0005829,GO:0005886,GO:0005975,GO:0006116,GO:0006654,GO:0009331,GO:0010765,GO:0017080,GO:0019674,GO:0033137,GO:0042803,GO:0044325,GO:0046168,GO:0051287,GO:0060373,GO:0070062,GO:0086005,GO:0090038,GO:2000010,GO:2000649" regulation of heart rate|glycerol-3-phosphate dehydrogenase [NAD+] activity|cytosol|plasma membrane|carbohydrate metabolic process|NADH oxidation|phosphatidic acid biosynthetic process|glycerol-3-phosphate dehydrogenase complex|positive regulation of sodium ion transport|sodium channel regulator activity|NAD metabolic process|negative regulation of peptidyl-serine phosphorylation|protein homodimerization activity|ion channel binding|glycerol-3-phosphate catabolic process|NAD binding|regulation of ventricular cardiac muscle cell membrane depolarization|extracellular exosome|ventricular cardiac muscle cell action potential|negative regulation of protein kinase C signaling|positive regulation of protein localization to cell surface|regulation of sodium ion transmembrane transporter activity hsa00564 Glycerophospholipid metabolism GPD2 631.7309104 584.6146378 678.847183 1.161187454 0.21560089 0.578414855 1 4.678993206 5.667227923 2820 glycerol-3-phosphate dehydrogenase 2 "GO:0004368,GO:0005509,GO:0005739,GO:0005743,GO:0006072,GO:0006127,GO:0009331,GO:0019563,GO:0052591" glycerol-3-phosphate dehydrogenase (quinone) activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|glycerol-3-phosphate metabolic process|glycerophosphate shuttle|glycerol-3-phosphate dehydrogenase complex|glycerol catabolic process|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity hsa00564 Glycerophospholipid metabolism GPER1 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.018760562 0.094981138 2852 G protein-coupled estrogen receptor 1 "GO:0000139,GO:0001934,GO:0001956,GO:0002695,GO:0003682,GO:0003707,GO:0004930,GO:0005496,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005730,GO:0005737,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0006954,GO:0007049,GO:0007186,GO:0007189,GO:0007204,GO:0008284,GO:0008285,GO:0010628,GO:0010629,GO:0010948,GO:0014068,GO:0014069,GO:0019228,GO:0030263,GO:0030264,GO:0030284,GO:0030335,GO:0030424,GO:0030425,GO:0030518,GO:0030659,GO:0031966,GO:0032024,GO:0032591,GO:0032962,GO:0042311,GO:0042734,GO:0043065,GO:0043198,GO:0043231,GO:0043280,GO:0043401,GO:0043410,GO:0043679,GO:0044327,GO:0045087,GO:0045095,GO:0045599,GO:0045742,GO:0045745,GO:0045944,GO:0048471,GO:0048786,GO:0050728,GO:0050769,GO:0051055,GO:0051281,GO:0051480,GO:0051898,GO:0055037,GO:0070373,GO:0070374,GO:0070474,GO:0071157,GO:0071333,GO:0071356,GO:0071375,GO:0071389,GO:0071392,GO:0090200,GO:1903078,GO:1904706,GO:1990239,GO:2000353,GO:2000724,GO:2001238" Golgi membrane|positive regulation of protein phosphorylation|positive regulation of neurotransmitter secretion|negative regulation of leukocyte activation|chromatin binding|steroid hormone receptor activity|G protein-coupled receptor activity|steroid binding|protein binding|nucleus|nuclear envelope|nucleoplasm|nucleolus|cytoplasm|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|integral component of plasma membrane|inflammatory response|cell cycle|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|positive regulation of cell population proliferation|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|negative regulation of cell cycle process|positive regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|neuronal action potential|apoptotic chromosome condensation|nuclear fragmentation involved in apoptotic nuclear change|estrogen receptor activity|positive regulation of cell migration|axon|dendrite|intracellular steroid hormone receptor signaling pathway|cytoplasmic vesicle membrane|mitochondrial membrane|positive regulation of insulin secretion|dendritic spine membrane|positive regulation of inositol trisphosphate biosynthetic process|vasodilation|presynaptic membrane|positive regulation of apoptotic process|dendritic shaft|intracellular membrane-bounded organelle|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|steroid hormone mediated signaling pathway|positive regulation of MAPK cascade|axon terminus|dendritic spine head|innate immune response|keratin filament|negative regulation of fat cell differentiation|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of G protein-coupled receptor signaling pathway|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|presynaptic active zone|negative regulation of inflammatory response|positive regulation of neurogenesis|negative regulation of lipid biosynthetic process|positive regulation of release of sequestered calcium ion into cytosol|regulation of cytosolic calcium ion concentration|negative regulation of protein kinase B signaling|recycling endosome|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of uterine smooth muscle contraction|negative regulation of cell cycle arrest|cellular response to glucose stimulus|cellular response to tumor necrosis factor|cellular response to peptide hormone stimulus|cellular response to mineralocorticoid stimulus|cellular response to estradiol stimulus|positive regulation of release of cytochrome c from mitochondria|positive regulation of protein localization to plasma membrane|negative regulation of vascular associated smooth muscle cell proliferation|steroid hormone binding|positive regulation of endothelial cell apoptotic process|positive regulation of cardiac vascular smooth muscle cell differentiation|positive regulation of extrinsic apoptotic signaling pathway "hsa01522,hsa04915,hsa04929" Endocrine resistance|Estrogen signaling pathway|GnRH secretion GPHN 618.1247604 664.7961593 571.4533616 0.859591852 -0.218276288 0.575581088 1 7.76333415 6.960757425 10243 gephyrin "GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006777,GO:0007529,GO:0008940,GO:0010038,GO:0014069,GO:0018315,GO:0030425,GO:0032324,GO:0042802,GO:0043546,GO:0045211,GO:0046872,GO:0055114,GO:0061598,GO:0061599,GO:0072579,GO:0097060,GO:0097112,GO:0098970,GO:0099144,GO:0099572,GO:0099634" protein binding|ATP binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|Mo-molybdopterin cofactor biosynthetic process|establishment of synaptic specificity at neuromuscular junction|nitrate reductase activity|response to metal ion|postsynaptic density|molybdenum incorporation into molybdenum-molybdopterin complex|dendrite|molybdopterin cofactor biosynthetic process|identical protein binding|molybdopterin cofactor binding|postsynaptic membrane|metal ion binding|oxidation-reduction process|molybdopterin adenylyltransferase activity|molybdopterin molybdotransferase activity|glycine receptor clustering|synaptic membrane|gamma-aminobutyric acid receptor clustering|postsynaptic neurotransmitter receptor diffusion trapping|anchored component of synaptic membrane|postsynaptic specialization|postsynaptic specialization membrane "hsa00790,hsa04727" Folate biosynthesis|GABAergic synapse GPI 6308.972966 8677.87353 3940.072402 0.454036624 -1.13911942 0.000539259 0.060405875 39.88960615 18.89150528 2821 glucose-6-phosphate isomerase "GO:0002639,GO:0004347,GO:0005125,GO:0005515,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0005975,GO:0006094,GO:0006096,GO:0006959,GO:0007165,GO:0007599,GO:0008083,GO:0010595,GO:0016020,GO:0031625,GO:0034774,GO:0043312,GO:0048029,GO:0051156,GO:0061621,GO:0070062,GO:1904813" positive regulation of immunoglobulin production|glucose-6-phosphate isomerase activity|cytokine activity|protein binding|extracellular region|nucleoplasm|cytosol|plasma membrane|carbohydrate metabolic process|gluconeogenesis|glycolytic process|humoral immune response|signal transduction|hemostasis|growth factor activity|positive regulation of endothelial cell migration|membrane|ubiquitin protein ligase binding|secretory granule lumen|neutrophil degranulation|monosaccharide binding|glucose 6-phosphate metabolic process|canonical glycolysis|extracellular exosome|ficolin-1-rich granule lumen "hsa00010,hsa00030,hsa00500,hsa00520" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism GPKOW 777.0937844 688.1401466 866.0474221 1.258533493 0.331743611 0.369705719 1 19.48120224 25.57387054 27238 G-patch domain and KOW motifs "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex" GPLD1 7.463712004 5.074779842 9.852644165 1.941491941 0.957165719 0.581982097 1 0.03245608 0.065727571 2822 glycosylphosphatidylinositol specific phospholipase D1 "GO:0001503,GO:0002042,GO:0002062,GO:0002430,GO:0004621,GO:0004630,GO:0005576,GO:0005615,GO:0005737,GO:0005765,GO:0006501,GO:0006507,GO:0008285,GO:0008286,GO:0009749,GO:0010595,GO:0010694,GO:0010867,GO:0010897,GO:0010907,GO:0010983,GO:0017080,GO:0031012,GO:0032869,GO:0035690,GO:0035701,GO:0035774,GO:0043065,GO:0043231,GO:0046470,GO:0051044,GO:0051047,GO:0070062,GO:0070633,GO:0071277,GO:0071397,GO:0071401,GO:0071467,GO:0097241,GO:1900076" ossification|cell migration involved in sprouting angiogenesis|chondrocyte differentiation|complement receptor mediated signaling pathway|glycosylphosphatidylinositol phospholipase D activity|phospholipase D activity|extracellular region|extracellular space|cytoplasm|lysosomal membrane|C-terminal protein lipidation|GPI anchor release|negative regulation of cell population proliferation|insulin receptor signaling pathway|response to glucose|positive regulation of endothelial cell migration|positive regulation of alkaline phosphatase activity|positive regulation of triglyceride biosynthetic process|negative regulation of triglyceride catabolic process|positive regulation of glucose metabolic process|positive regulation of high-density lipoprotein particle clearance|sodium channel regulator activity|extracellular matrix|cellular response to insulin stimulus|cellular response to drug|hematopoietic stem cell migration|positive regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of apoptotic process|intracellular membrane-bounded organelle|phosphatidylcholine metabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of secretion|extracellular exosome|transepithelial transport|cellular response to calcium ion|cellular response to cholesterol|cellular response to triglyceride|cellular response to pH|hematopoietic stem cell migration to bone marrow|regulation of cellular response to insulin stimulus hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis GPM6A 11.47899855 10.14955968 12.80843742 1.261969762 0.335677342 0.860335721 1 0.145744086 0.191847357 2823 glycoprotein M6A "GO:0001764,GO:0003407,GO:0005262,GO:0005515,GO:0005886,GO:0007416,GO:0009617,GO:0030175,GO:0031175,GO:0043005,GO:0043025,GO:0043197,GO:0044295,GO:0048812,GO:0048863,GO:0050807,GO:0051491,GO:0070062,GO:0070588,GO:0098978,GO:0099059,GO:1903561" neuron migration|neural retina development|calcium channel activity|protein binding|plasma membrane|synapse assembly|response to bacterium|filopodium|neuron projection development|neuron projection|neuronal cell body|dendritic spine|axonal growth cone|neuron projection morphogenesis|stem cell differentiation|regulation of synapse organization|positive regulation of filopodium assembly|extracellular exosome|calcium ion transmembrane transport|glutamatergic synapse|integral component of presynaptic active zone membrane|extracellular vesicle GPM6B 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.032122812 2824 glycoprotein M6B "GO:0001503,GO:0003674,GO:0005886,GO:0007399,GO:0015031,GO:0016021,GO:0030501,GO:0031175,GO:0032956,GO:0045121,GO:0051612,GO:0051893,GO:0085029,GO:2000009" ossification|molecular_function|plasma membrane|nervous system development|protein transport|integral component of membrane|positive regulation of bone mineralization|neuron projection development|regulation of actin cytoskeleton organization|membrane raft|negative regulation of serotonin uptake|regulation of focal adhesion assembly|extracellular matrix assembly|negative regulation of protein localization to cell surface GPN1 690.7616601 713.5140458 668.0092744 0.936224421 -0.095073697 0.804831468 1 12.12243183 11.83819926 11321 GPN-loop GTPase 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005739,GO:0005829" GTPase activity|protein binding|GTP binding|nucleoplasm|mitochondrion|cytosol GPN2 979.7732167 1072.808459 886.7379749 0.826557591 -0.274812751 0.437560143 1 11.64715194 10.04173576 54707 GPN-loop GTPase 2 "GO:0003674,GO:0003924,GO:0005515,GO:0005525,GO:0005575,GO:0008150" molecular_function|GTPase activity|protein binding|GTP binding|cellular_component|biological_process GPN3 655.0654951 563.3005624 746.8304277 1.325811614 0.406875796 0.288619121 1 16.40551253 22.68754749 51184 GPN-loop GTPase 3 "GO:0003924,GO:0005515,GO:0005525,GO:0032991" GTPase activity|protein binding|GTP binding|protein-containing complex GPNMB 8.986145956 8.119647747 9.852644165 1.213432463 0.279093814 0.926248221 1 0.147289224 0.186424297 10457 glycoprotein nmb "GO:0001818,GO:0001934,GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007165,GO:0007267,GO:0008201,GO:0008285,GO:0016021,GO:0030335,GO:0031901,GO:0031954,GO:0033162,GO:0034103,GO:0042056,GO:0042130,GO:0045545,GO:0045765,GO:0048018,GO:0050868,GO:0050918,GO:0070374,GO:1901215,GO:2000134" negative regulation of cytokine production|positive regulation of protein phosphorylation|integrin binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|signal transduction|cell-cell signaling|heparin binding|negative regulation of cell population proliferation|integral component of membrane|positive regulation of cell migration|early endosome membrane|positive regulation of protein autophosphorylation|melanosome membrane|regulation of tissue remodeling|chemoattractant activity|negative regulation of T cell proliferation|syndecan binding|regulation of angiogenesis|receptor ligand activity|negative regulation of T cell activation|positive chemotaxis|positive regulation of ERK1 and ERK2 cascade|negative regulation of neuron death|negative regulation of G1/S transition of mitotic cell cycle GPR107 3914.458263 4008.061119 3820.855407 0.9532927 -0.069008846 0.829106667 1 29.5178357 29.35125721 57720 G protein-coupled receptor 107 "GO:0005654,GO:0005769,GO:0005794,GO:0005886,GO:0006810,GO:0016020,GO:0016021,GO:0030136,GO:0032050,GO:0072583" nucleoplasm|early endosome|Golgi apparatus|plasma membrane|transport|membrane|integral component of membrane|clathrin-coated vesicle|clathrin heavy chain binding|clathrin-dependent endocytosis GPR108 1186.217041 1243.321061 1129.113021 0.908142761 -0.139008986 0.686305348 1 25.03770401 23.71726227 56927 G protein-coupled receptor 108 "GO:0005515,GO:0005794,GO:0006810,GO:0016020,GO:0016021" protein binding|Golgi apparatus|transport|membrane|integral component of membrane GPR135 136.5818473 143.1087915 130.054903 0.908783462 -0.137991514 0.831543832 1 0.819626307 0.776948503 64582 G protein-coupled receptor 135 "GO:0004930,GO:0005515,GO:0005768,GO:0005886,GO:0007186,GO:0010008,GO:0016021,GO:1990763" G protein-coupled receptor activity|protein binding|endosome|plasma membrane|G protein-coupled receptor signaling pathway|endosome membrane|integral component of membrane|arrestin family protein binding GPR137 963.7108328 884.0266485 1043.395017 1.180275526 0.239123684 0.500910701 1 14.79115662 18.20964449 56834 G protein-coupled receptor 137 "GO:0005765,GO:0006914,GO:0010506,GO:0016021,GO:0045671,GO:0045779,GO:1904263" lysosomal membrane|autophagy|regulation of autophagy|integral component of membrane|negative regulation of osteoclast differentiation|negative regulation of bone resorption|positive regulation of TORC1 signaling GPR137B 520.5499323 527.7771036 513.322761 0.97261279 -0.040062532 0.925955226 1 3.522673749 3.573784237 7107 G protein-coupled receptor 137B "GO:0005515,GO:0005765,GO:0005887,GO:0006914,GO:0010506,GO:0016020,GO:0043030,GO:0043087,GO:0045671,GO:0045779,GO:0150032,GO:1904263" protein binding|lysosomal membrane|integral component of plasma membrane|autophagy|regulation of autophagy|membrane|regulation of macrophage activation|regulation of GTPase activity|negative regulation of osteoclast differentiation|negative regulation of bone resorption|positive regulation of protein localization to lysosome|positive regulation of TORC1 signaling GPR137C 112.6385857 122.8096722 102.4674993 0.834360173 -0.2612578 0.69666347 1 1.182036611 1.028727675 283554 G protein-coupled receptor 137C "GO:0005765,GO:0016021,GO:1904263" lysosomal membrane|integral component of membrane|positive regulation of TORC1 signaling GPR143 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.253221376 0.113956571 4935 G protein-coupled receptor 143 "GO:0004930,GO:0005515,GO:0005737,GO:0005765,GO:0005794,GO:0005886,GO:0006726,GO:0007165,GO:0007186,GO:0007218,GO:0007601,GO:0016020,GO:0016021,GO:0016324,GO:0032400,GO:0032402,GO:0032438,GO:0033162,GO:0035240,GO:0035584,GO:0035643,GO:0042470,GO:0048015,GO:0050848,GO:0072544,GO:0072545" G protein-coupled receptor activity|protein binding|cytoplasm|lysosomal membrane|Golgi apparatus|plasma membrane|eye pigment biosynthetic process|signal transduction|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|visual perception|membrane|integral component of membrane|apical plasma membrane|melanosome localization|melanosome transport|melanosome organization|melanosome membrane|dopamine binding|calcium-mediated signaling using intracellular calcium source|L-DOPA receptor activity|melanosome|phosphatidylinositol-mediated signaling|regulation of calcium-mediated signaling|L-DOPA binding|tyrosine binding GPR146 53.48090503 86.27125731 20.69055275 0.239831357 -2.059907795 0.016457338 0.56614915 1.808499518 0.452418435 115330 G protein-coupled receptor 146 "GO:0004930,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane GPR153 388.4287448 420.1917709 356.6657188 0.848816525 -0.236475352 0.591137197 1 4.727061495 4.185246171 387509 G protein-coupled receptor 153 "GO:0004930,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane GPR155 73.08227293 79.16656553 66.99798033 0.846291359 -0.240773659 0.761778123 1 0.509855959 0.450073389 151556 G protein-coupled receptor 155 "GO:0003674,GO:0016021,GO:0035556,GO:0050890,GO:0055085,GO:0070062" molecular_function|integral component of membrane|intracellular signal transduction|cognition|transmembrane transport|extracellular exosome GPR156 61.00672174 61.91231407 60.10112941 0.970745971 -0.042834281 0.980081854 1 0.600697374 0.608243197 165829 G protein-coupled receptor 156 "GO:0004888,GO:0004965,GO:0005886,GO:0007214,GO:0038039" transmembrane signaling receptor activity|G protein-coupled GABA receptor activity|plasma membrane|gamma-aminobutyric acid signaling pathway|G protein-coupled receptor heterodimeric complex hsa04080 Neuroactive ligand-receptor interaction GPR157 189.8252199 213.1407534 166.5096864 0.781219376 -0.356200363 0.518863692 1 2.083943483 1.698145399 80045 G protein-coupled receptor 157 "GO:0004930,GO:0007166,GO:0007186,GO:0016021,GO:0048512,GO:0051482,GO:0060019,GO:0060170" G protein-coupled receptor activity|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|integral component of membrane|circadian behavior|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|radial glial cell differentiation|ciliary membrane GPR158 79.21654607 94.39090506 64.04218708 0.678478366 -0.559625279 0.448334673 1 0.656581012 0.464665313 57512 G protein-coupled receptor 158 "GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0072659" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|protein localization to plasma membrane GPR160 82.33564285 105.5554207 59.11586499 0.560045752 -0.836383404 0.248370539 1 1.639377394 0.957675505 26996 G protein-coupled receptor 160 "GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0016021,GO:0043235" G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|receptor complex GPR161 1831.096604 1682.796996 1979.396213 1.176253712 0.234199276 0.470796568 1 8.927174115 10.95294589 23432 G protein-coupled receptor 161 "GO:0004930,GO:0005515,GO:0005929,GO:0007186,GO:0007189,GO:0007275,GO:0016021,GO:0030666,GO:0055037,GO:0060170,GO:1901621" G protein-coupled receptor activity|protein binding|cilium|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|multicellular organism development|integral component of membrane|endocytic vesicle membrane|recycling endosome|ciliary membrane|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning hsa04340 Hedgehog signaling pathway GPR162 108.3115379 96.420817 120.2022588 1.246642194 0.318047448 0.637022303 1 3.270846771 4.253221013 27239 G protein-coupled receptor 162 "GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane GPR173 825.0045557 797.7553911 852.2537203 1.068314586 0.095336539 0.796573899 1 8.13766289 9.068068299 54328 G protein-coupled receptor 173 "GO:0004930,GO:0004968,GO:0005886,GO:0007165,GO:0007186,GO:0016021,GO:0097211" G protein-coupled receptor activity|gonadotropin-releasing hormone receptor activity|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|integral component of membrane|cellular response to gonadotropin-releasing hormone GPR176 1885.012242 1563.032191 2206.992293 1.411994139 0.4977341 0.124526326 1 8.68767191 12.79535192 11245 G protein-coupled receptor 176 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0007268,GO:0045202,GO:0048512" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|chemical synaptic transmission|synapse|circadian behavior GPR179 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.016826167 0 440435 G protein-coupled receptor 179 "GO:0004930,GO:0005886,GO:0007186,GO:0007601,GO:0016021" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|visual perception|integral component of membrane GPR180 730.8551424 760.2020203 701.5082646 0.922791897 -0.115922759 0.759311701 1 4.333808025 4.171472373 160897 G protein-coupled receptor 180 "GO:0007186,GO:0016021,GO:0019236" G protein-coupled receptor signaling pathway|integral component of membrane|response to pheromone GPR19 20.42060718 15.22433953 25.61687483 1.682626349 0.750714841 0.512228503 1 0.111055608 0.194914483 2842 G protein-coupled receptor 19 "GO:0004930,GO:0005887,GO:0005929,GO:0007186" G protein-coupled receptor activity|integral component of plasma membrane|cilium|G protein-coupled receptor signaling pathway GPR3 170.4074445 165.4378228 175.3770661 1.060078422 0.084170995 0.892150764 1 3.920843284 4.335442274 2827 G protein-coupled receptor 3 "GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007189,GO:0019222,GO:0040020,GO:0120162" G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|adenylate cyclase-activating G protein-coupled receptor signaling pathway|regulation of metabolic process|regulation of meiotic nuclear division|positive regulation of cold-induced thermogenesis GPR35 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.110167037 0.044620372 2859 G protein-coupled receptor 35 "GO:0004930,GO:0005886,GO:0005887,GO:0007010,GO:0007186,GO:0007204,GO:0016494,GO:0035025,GO:0051482,GO:0070098,GO:1901386,GO:1904456" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|cytoskeleton organization|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|C-X-C chemokine receptor activity|positive regulation of Rho protein signal transduction|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|chemokine-mediated signaling pathway|negative regulation of voltage-gated calcium channel activity|negative regulation of neuronal action potential hsa04080 Neuroactive ligand-receptor interaction GPR39 263.6376574 308.5466144 218.7287005 0.708900018 -0.496345928 0.314418116 1 6.06630339 4.485646484 2863 G protein-coupled receptor 39 "GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0046872" G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|metal ion binding GPR4 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.03542656 0.011957194 2828 G protein-coupled receptor 4 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007189,GO:0007200,GO:0010447,GO:0016525,GO:0030155,GO:0035025,GO:0043114,GO:0050729,GO:0051482,GO:0060055,GO:0072144" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|response to acidic pH|negative regulation of angiogenesis|regulation of cell adhesion|positive regulation of Rho protein signal transduction|regulation of vascular permeability|positive regulation of inflammatory response|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|angiogenesis involved in wound healing|glomerular mesangial cell development GPR55 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.044000804 0 9290 G protein-coupled receptor 55 "GO:0004930,GO:0004949,GO:0005886,GO:0005887,GO:0007186,GO:0007202,GO:0035025,GO:0038171,GO:0045453,GO:0045671,GO:0051482,GO:0070374" G protein-coupled receptor activity|cannabinoid receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of Rho protein signal transduction|cannabinoid signaling pathway|bone resorption|negative regulation of osteoclast differentiation|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of ERK1 and ERK2 cascade GPR63 63.55895744 68.00204988 59.11586499 0.86932475 -0.202032876 0.813490313 1 0.472048236 0.428039998 81491 G protein-coupled receptor 63 "GO:0003674,GO:0004930,GO:0005654,GO:0005829,GO:0005886,GO:0007186,GO:0008150,GO:0016021,GO:0043235" molecular_function|G protein-coupled receptor activity|nucleoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|biological_process|integral component of membrane|receptor complex GPR68 40.48219413 39.58328277 41.38110549 1.045418737 0.064080923 0.973729017 1 0.326294536 0.355808248 8111 G protein-coupled receptor 68 "GO:0004930,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0035774,GO:0045656,GO:0071467,GO:2001206" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|positive regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of monocyte differentiation|cellular response to pH|positive regulation of osteoclast development GPR75 56.27339474 75.10674166 37.44004783 0.498491174 -1.004360133 0.220779759 1 1.816567099 0.944549771 10936 G protein-coupled receptor 75 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0016493,GO:0070098,GO:1901214" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|C-C chemokine receptor activity|chemokine-mediated signaling pathway|regulation of neuron death GPR83 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.060093452 0.036509 10888 G protein-coupled receptor 83 "GO:0004930,GO:0004983,GO:0005886,GO:0005929,GO:0007186,GO:0007218,GO:0016021,GO:0051384,GO:0097730" G protein-coupled receptor activity|neuropeptide Y receptor activity|plasma membrane|cilium|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|integral component of membrane|response to glucocorticoid|non-motile cilium "hsa04080,hsa05010" Neuroactive ligand-receptor interaction|Alzheimer disease GPR85 48.34946369 38.5683268 58.13060058 1.507210849 0.591881255 0.496904664 1 0.487727763 0.766774072 54329 G protein-coupled receptor 85 "GO:0004930,GO:0005515,GO:0005783,GO:0005886,GO:0007165,GO:0007186,GO:0016021" G protein-coupled receptor activity|protein binding|endoplasmic reticulum|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|integral component of membrane GPR89A 155.1952291 169.4976467 140.8928116 0.831237568 -0.266667237 0.654777578 1 2.820124131 2.445171455 653519 G protein-coupled receptor 89A "GO:0008308,GO:0015031,GO:0015698,GO:0016021,GO:0030217,GO:0030660,GO:0032580,GO:0034220,GO:0034765,GO:0043123,GO:0051452" voltage-gated anion channel activity|protein transport|inorganic anion transport|integral component of membrane|T cell differentiation|Golgi-associated vesicle membrane|Golgi cisterna membrane|ion transmembrane transport|regulation of ion transmembrane transport|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular pH reduction GPR89B 140.468965 72.06187375 208.8760563 2.898565433 1.535339054 0.01267784 0.498073746 1.299743478 3.929675465 51463 G protein-coupled receptor 89B "GO:0005515,GO:0008308,GO:0015031,GO:0015698,GO:0016021,GO:0030217,GO:0032580,GO:0034220,GO:0034765,GO:0051452" protein binding|voltage-gated anion channel activity|protein transport|inorganic anion transport|integral component of membrane|T cell differentiation|Golgi cisterna membrane|ion transmembrane transport|regulation of ion transmembrane transport|intracellular pH reduction GPRASP1 32.57038725 37.55337083 27.58740366 0.734618572 -0.444932725 0.661604067 1 0.322309058 0.246973493 9737 G protein-coupled receptor associated sorting protein 1 "GO:0005515,GO:0005829,GO:0008333,GO:1990172" protein binding|cytosol|endosome to lysosome transport|G protein-coupled receptor catabolic process GPRASP2 3.47811701 2.029911937 4.926322083 2.426864926 1.279093814 0.644064692 1 0.027763402 0.070280399 114928 G protein-coupled receptor associated sorting protein 2 "GO:0001540,GO:0001664,GO:0005515,GO:0005634,GO:0005737,GO:0061484" amyloid-beta binding|G protein-coupled receptor binding|protein binding|nucleus|cytoplasm|hematopoietic stem cell homeostasis GPRC5A 1959.895805 2438.939192 1480.852418 0.607170701 -0.71982592 0.026211228 0.720197064 18.7668894 11.88554308 9052 G protein-coupled receptor class C group 5 member A "GO:0004930,GO:0005515,GO:0005730,GO:0005886,GO:0005887,GO:0007165,GO:0007175,GO:0007186,GO:0030295,GO:0030659,GO:0031982,GO:0032147,GO:0043231,GO:0043235,GO:0045296,GO:0070062" G protein-coupled receptor activity|protein binding|nucleolus|plasma membrane|integral component of plasma membrane|signal transduction|negative regulation of epidermal growth factor-activated receptor activity|G protein-coupled receptor signaling pathway|protein kinase activator activity|cytoplasmic vesicle membrane|vesicle|activation of protein kinase activity|intracellular membrane-bounded organelle|receptor complex|cadherin binding|extracellular exosome GPRC5B 737.8098926 966.2380819 509.3817034 0.527180322 -0.923631574 0.013894862 0.521881214 8.457751497 4.650825464 51704 G protein-coupled receptor class C group 5 member B "GO:0001664,GO:0004930,GO:0005615,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0007186,GO:0009986,GO:0016021,GO:0019901,GO:0030295,GO:0030659,GO:0032147,GO:0043123,GO:0043231,GO:0043235,GO:0045666,GO:0050729,GO:0060907,GO:0061098,GO:0070062,GO:0090263" G protein-coupled receptor binding|G protein-coupled receptor activity|extracellular space|nucleoplasm|nucleolus|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|cell surface|integral component of membrane|protein kinase binding|protein kinase activator activity|cytoplasmic vesicle membrane|activation of protein kinase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|receptor complex|positive regulation of neuron differentiation|positive regulation of inflammatory response|positive regulation of macrophage cytokine production|positive regulation of protein tyrosine kinase activity|extracellular exosome|positive regulation of canonical Wnt signaling pathway GPRC5C 48.28735898 68.00204988 28.57266808 0.420173629 -1.250942477 0.146986278 1 0.636493057 0.278957725 55890 G protein-coupled receptor class C group 5 member C "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0030295,GO:0030659,GO:0031982,GO:0032147,GO:0043231,GO:0043235,GO:0070062" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|protein kinase activator activity|cytoplasmic vesicle membrane|vesicle|activation of protein kinase activity|intracellular membrane-bounded organelle|receptor complex|extracellular exosome GPRIN1 699.3254434 591.7193296 806.9315572 1.363706604 0.447533287 0.23634696 1 7.078057766 10.06818011 114787 G protein regulated inducer of neurite outgrowth 1 "GO:0005886,GO:0030426,GO:0031175,GO:0051219" plasma membrane|growth cone|neuron projection development|phosphoprotein binding GPRIN3 15.01649866 16.23929549 13.79370183 0.849402724 -0.235479359 0.899738079 1 0.04973171 0.044061875 285513 GPRIN family member 3 "GO:0005886,GO:0031175" plasma membrane|neuron projection development GPS1 1777.515738 1724.41019 1830.621286 1.061592709 0.086230368 0.792271533 1 41.13767913 45.55264963 2873 G protein pathway suppressor 1 "GO:0000188,GO:0000338,GO:0000715,GO:0005095,GO:0005515,GO:0005654,GO:0005829,GO:0006283,GO:0007254,GO:0008180,GO:0034260,GO:0043687" "inactivation of MAPK activity|protein deneddylation|nucleotide-excision repair, DNA damage recognition|GTPase inhibitor activity|protein binding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|JNK cascade|COP9 signalosome|negative regulation of GTPase activity|post-translational protein modification" GPS2 1179.13536 1129.645993 1228.624727 1.08761925 0.121173591 0.725392367 1 48.65015679 55.19211789 2874 G protein pathway suppressor 2 "GO:0000122,GO:0000188,GO:0003713,GO:0003714,GO:0005095,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0007254,GO:0010804,GO:0010875,GO:0016032,GO:0017053,GO:0019216,GO:0030183,GO:0030332,GO:0034122,GO:0034260,GO:0035360,GO:0045598,GO:0045599,GO:0045944,GO:0046329,GO:0050728,GO:0050859,GO:0098780,GO:1900045" negative regulation of transcription by RNA polymerase II|inactivation of MAPK activity|transcription coactivator activity|transcription corepressor activity|GTPase inhibitor activity|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|JNK cascade|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cholesterol efflux|viral process|transcription repressor complex|regulation of lipid metabolic process|B cell differentiation|cyclin binding|negative regulation of toll-like receptor signaling pathway|negative regulation of GTPase activity|positive regulation of peroxisome proliferator activated receptor signaling pathway|regulation of fat cell differentiation|negative regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|negative regulation of inflammatory response|negative regulation of B cell receptor signaling pathway|response to mitochondrial depolarisation|negative regulation of protein K63-linked ubiquitination hsa05166 Human T-cell leukemia virus 1 infection GPSM1 598.7502846 451.6554059 745.8451633 1.651358876 0.723653683 0.064874624 1 4.846345967 8.347795641 26086 G protein signaling modulator 1 "GO:0000139,GO:0005092,GO:0005515,GO:0005789,GO:0005829,GO:0005886,GO:0005938,GO:0007399,GO:0016239,GO:0030154,GO:0032991,GO:0034260,GO:1905098" Golgi membrane|GDP-dissociation inhibitor activity|protein binding|endoplasmic reticulum membrane|cytosol|plasma membrane|cell cortex|nervous system development|positive regulation of macroautophagy|cell differentiation|protein-containing complex|negative regulation of GTPase activity|negative regulation of guanyl-nucleotide exchange factor activity hsa05030 Cocaine addiction GPSM2 991.5330473 933.7594909 1049.306604 1.123743977 0.168313383 0.63472029 1 6.869788511 8.052424731 29899 G protein signaling modulator 2 "GO:0000132,GO:0000166,GO:0005092,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005938,GO:0007052,GO:0007186,GO:0008022,GO:0016328,GO:0019904,GO:0031291,GO:0032991,GO:0042802,GO:0043621,GO:0050790,GO:0051301,GO:0051661,GO:0060236,GO:0070840,GO:0097431,GO:0097575,GO:0099738,GO:1904778,GO:1905832" establishment of mitotic spindle orientation|nucleotide binding|GDP-dissociation inhibitor activity|protein binding|cytoplasm|centrosome|cytosol|cell cortex|mitotic spindle organization|G protein-coupled receptor signaling pathway|protein C-terminus binding|lateral plasma membrane|protein domain specific binding|Ran protein signal transduction|protein-containing complex|identical protein binding|protein self-association|regulation of catalytic activity|cell division|maintenance of centrosome location|regulation of mitotic spindle organization|dynein complex binding|mitotic spindle pole|lateral cell cortex|cell cortex region|positive regulation of protein localization to cell cortex|positive regulation of spindle assembly GPSM3 166.8496554 225.320225 108.3790858 0.481000256 -1.055890434 0.066136961 1 7.273215114 3.649116002 63940 G protein signaling modulator 3 "GO:0002690,GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0005886,GO:0008150,GO:0030695,GO:0050729,GO:0050790,GO:1900017" positive regulation of leukocyte chemotaxis|molecular_function|protein binding|cellular_component|cytoplasm|plasma membrane|biological_process|GTPase regulator activity|positive regulation of inflammatory response|regulation of catalytic activity|positive regulation of cytokine production involved in inflammatory response GPT 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.163533211 0.055195826 2875 glutamic--pyruvic transaminase "GO:0004021,GO:0005829,GO:0008652,GO:0030170,GO:0032869,GO:0042594,GO:0042853,GO:0045722,GO:0070062" L-alanine:2-oxoglutarate aminotransferase activity|cytosol|cellular amino acid biosynthetic process|pyridoxal phosphate binding|cellular response to insulin stimulus|response to starvation|L-alanine catabolic process|positive regulation of gluconeogenesis|extracellular exosome "hsa00220,hsa00250" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism" GPT2 1296.949925 1303.203463 1290.696386 0.99040282 -0.013912672 0.96967059 1 14.61529185 15.0985517 84706 glutamic--pyruvic transaminase 2 "GO:0004021,GO:0005759,GO:0006103,GO:0008652,GO:0030170,GO:0042851,GO:0042853" L-alanine:2-oxoglutarate aminotransferase activity|mitochondrial matrix|2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|pyridoxal phosphate binding|L-alanine metabolic process|L-alanine catabolic process "hsa00220,hsa00250" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism" GPX1 7441.412425 7423.387953 7459.436898 1.004856131 0.00698896 0.983497236 1 319.1582442 334.5229235 2876 glutathione peroxidase 1 "GO:0001659,GO:0001885,GO:0002862,GO:0004601,GO:0004602,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006195,GO:0006641,GO:0006749,GO:0007605,GO:0009410,GO:0009609,GO:0009650,GO:0010269,GO:0010332,GO:0017124,GO:0018158,GO:0019369,GO:0019372,GO:0033194,GO:0033599,GO:0034599,GO:0040029,GO:0042311,GO:0042542,GO:0042744,GO:0043154,GO:0043403,GO:0043534,GO:0045444,GO:0045454,GO:0047066,GO:0048741,GO:0051450,GO:0051702,GO:0051897,GO:0060047,GO:0060055,GO:0061136,GO:0090201,GO:0097413,GO:0098869,GO:1902042,GO:1902176,GO:1902905" "temperature homeostasis|endothelial cell development|negative regulation of inflammatory response to antigenic stimulus|peroxidase activity|glutathione peroxidase activity|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|purine nucleotide catabolic process|triglyceride metabolic process|glutathione metabolic process|sensory perception of sound|response to xenobiotic stimulus|response to symbiotic bacterium|UV protection|response to selenium ion|response to gamma radiation|SH3 domain binding|protein oxidation|arachidonic acid metabolic process|lipoxygenase pathway|response to hydroperoxide|regulation of mammary gland epithelial cell proliferation|cellular response to oxidative stress|regulation of gene expression, epigenetic|vasodilation|response to hydrogen peroxide|hydrogen peroxide catabolic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|skeletal muscle tissue regeneration|blood vessel endothelial cell migration|fat cell differentiation|cell redox homeostasis|phospholipid-hydroperoxide glutathione peroxidase activity|skeletal muscle fiber development|myoblast proliferation|biological process involved in interaction with symbiont|positive regulation of protein kinase B signaling|heart contraction|angiogenesis involved in wound healing|regulation of proteasomal protein catabolic process|negative regulation of release of cytochrome c from mitochondria|Lewy body|cellular oxidant detoxification|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of supramolecular fiber organization" "hsa00480,hsa00590,hsa04918,hsa05014,hsa05016,hsa05022" Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases GPX4 5929.727314 6393.207645 5466.246983 0.855008516 -0.225989305 0.485744415 1 280.8268979 250.4523281 2879 glutathione peroxidase 4 "GO:0004601,GO:0004602,GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0006644,GO:0006979,GO:0007275,GO:0007283,GO:0019369,GO:0019372,GO:0032991,GO:0042759,GO:0042802,GO:0047066,GO:0051258,GO:0055114,GO:0070062,GO:0098869,GO:0110076" peroxidase activity|glutathione peroxidase activity|protein binding|nucleus|mitochondrion|cytosol|phospholipid metabolic process|response to oxidative stress|multicellular organism development|spermatogenesis|arachidonic acid metabolic process|lipoxygenase pathway|protein-containing complex|long-chain fatty acid biosynthetic process|identical protein binding|phospholipid-hydroperoxide glutathione peroxidase activity|protein polymerization|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification|negative regulation of ferroptosis "hsa00480,hsa04216" Glutathione metabolism|Ferroptosis GPX7 184.7059027 199.9463258 169.4654796 0.847554858 -0.238621346 0.671683152 1 8.239687577 7.284411845 2882 glutathione peroxidase 7 "GO:0004096,GO:0004601,GO:0004602,GO:0005515,GO:0005576,GO:0005783,GO:0005788,GO:0034599,GO:0055114,GO:0098869" catalase activity|peroxidase activity|glutathione peroxidase activity|protein binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|cellular response to oxidative stress|oxidation-reduction process|cellular oxidant detoxification "hsa00480,hsa00590,hsa04918,hsa05014,hsa05016,hsa05022" Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases GPX8 1772.102227 1657.423096 1886.781358 1.138382446 0.18698532 0.566194276 1 22.38470208 26.58002827 493869 glutathione peroxidase 8 (putative) "GO:0004601,GO:0004602,GO:0005515,GO:0005788,GO:0016021,GO:0034599,GO:0055114,GO:0098869" peroxidase activity|glutathione peroxidase activity|protein binding|endoplasmic reticulum lumen|integral component of membrane|cellular response to oxidative stress|oxidation-reduction process|cellular oxidant detoxification "hsa00480,hsa00590,hsa04918,hsa05014,hsa05016,hsa05022" Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases GRAMD1A 1410.213517 1266.665049 1553.761985 1.226655766 0.294730445 0.378018482 1 15.54449144 19.88910096 57655 GRAM domain containing 1A "GO:0005515,GO:0005776,GO:0005829,GO:0005886,GO:0006914,GO:0015485,GO:0015918,GO:0016021,GO:0031227,GO:0031234,GO:0031410,GO:0044232,GO:0071397,GO:0120009,GO:0120020,GO:0140268" protein binding|autophagosome|cytosol|plasma membrane|autophagy|cholesterol binding|sterol transport|integral component of membrane|intrinsic component of endoplasmic reticulum membrane|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|organelle membrane contact site|cellular response to cholesterol|intermembrane lipid transfer|cholesterol transfer activity|endoplasmic reticulum-plasma membrane contact site GRAMD1B 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.008056623 0.002719276 57476 GRAM domain containing 1B "GO:0001786,GO:0005789,GO:0005886,GO:0015485,GO:0015918,GO:0016020,GO:0016021,GO:0042632,GO:0070300,GO:0071397,GO:0120009,GO:0120020,GO:0140268" phosphatidylserine binding|endoplasmic reticulum membrane|plasma membrane|cholesterol binding|sterol transport|membrane|integral component of membrane|cholesterol homeostasis|phosphatidic acid binding|cellular response to cholesterol|intermembrane lipid transfer|cholesterol transfer activity|endoplasmic reticulum-plasma membrane contact site GRAMD1C 104.0411516 107.5853326 100.4969705 0.934114047 -0.098329394 0.897070495 1 1.152457183 1.122898836 54762 GRAM domain containing 1C "GO:0005515,GO:0005789,GO:0005886,GO:0015485,GO:0015918,GO:0016021,GO:0071397,GO:0120009,GO:0120020,GO:0140268" protein binding|endoplasmic reticulum membrane|plasma membrane|cholesterol binding|sterol transport|integral component of membrane|cellular response to cholesterol|intermembrane lipid transfer|cholesterol transfer activity|endoplasmic reticulum-plasma membrane contact site GRAMD2A 3.463271234 1.014955968 5.911586499 5.824475823 2.542128219 0.321345721 1 0.010731511 0.065197909 196996 GRAM domain containing 2A "GO:0005515,GO:0005546,GO:0016021,GO:0031227,GO:0031234,GO:0035091,GO:0044232,GO:0061817,GO:2001256" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|integral component of membrane|intrinsic component of endoplasmic reticulum membrane|extrinsic component of cytoplasmic side of plasma membrane|phosphatidylinositol binding|organelle membrane contact site|endoplasmic reticulum-plasma membrane tethering|regulation of store-operated calcium entry" GRAMD2B 87.0986614 94.39090506 79.80641774 0.845488426 -0.242143089 0.744025983 1 0.972450437 0.857612441 65983 GRAM domain containing 2B "GO:0005515,GO:0005881,GO:0042802" protein binding|cytoplasmic microtubule|identical protein binding GRAMD4 500.9782559 536.9117073 465.0448046 0.866147633 -0.207315144 0.613916353 1 4.865393427 4.39567745 23151 GRAM domain containing 4 "GO:0003674,GO:0005515,GO:0005739,GO:0005789,GO:0006915,GO:0016021,GO:0031966,GO:0034164,GO:0043280" molecular_function|protein binding|mitochondrion|endoplasmic reticulum membrane|apoptotic process|integral component of membrane|mitochondrial membrane|negative regulation of toll-like receptor 9 signaling pathway|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GRB10 1806.933378 1613.77999 2000.086766 1.239380076 0.309618681 0.340769534 1 6.893165506 8.911260633 2887 growth factor receptor bound protein 10 "GO:0005158,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007411,GO:0008286,GO:0030178,GO:0030949,GO:0032991,GO:0046325,GO:0046627,GO:0120162" insulin receptor binding|protein binding|cytoplasm|cytosol|plasma membrane|axon guidance|insulin receptor signaling pathway|negative regulation of Wnt signaling pathway|positive regulation of vascular endothelial growth factor receptor signaling pathway|protein-containing complex|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|positive regulation of cold-induced thermogenesis hsa04150 mTOR signaling pathway GRB14 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.028478637 0.057672758 2888 growth factor receptor bound protein 14 "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0008286,GO:0010008,GO:0030674,GO:0030971,GO:0043231,GO:0046627,GO:0050900" protein binding|cytoplasm|cytosol|plasma membrane|signal transduction|insulin receptor signaling pathway|endosome membrane|protein-macromolecule adaptor activity|receptor tyrosine kinase binding|intracellular membrane-bounded organelle|negative regulation of insulin receptor signaling pathway|leukocyte migration GRB2 3145.841909 3158.542974 3133.140845 0.991957643 -0.011649576 0.971870694 1 48.87536173 50.57070901 2885 growth factor receptor bound protein 2 "GO:0000165,GO:0001784,GO:0003723,GO:0005154,GO:0005168,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0005911,GO:0007173,GO:0007265,GO:0007411,GO:0007568,GO:0008180,GO:0008286,GO:0008543,GO:0012506,GO:0016032,GO:0017124,GO:0019221,GO:0019901,GO:0019903,GO:0030674,GO:0030838,GO:0031295,GO:0031532,GO:0031623,GO:0035635,GO:0035723,GO:0038095,GO:0038096,GO:0038128,GO:0042059,GO:0042770,GO:0042802,GO:0043408,GO:0043560,GO:0044877,GO:0046579,GO:0046875,GO:0048011,GO:0048646,GO:0050900,GO:0051897,GO:0060670,GO:0061024,GO:0070062,GO:0070436,GO:0071479,GO:2000379" MAPK cascade|phosphotyrosine residue binding|RNA binding|epidermal growth factor receptor binding|neurotrophin TRKA receptor binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|cell-cell junction|epidermal growth factor receptor signaling pathway|Ras protein signal transduction|axon guidance|aging|COP9 signalosome|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|vesicle membrane|viral process|SH3 domain binding|cytokine-mediated signaling pathway|protein kinase binding|protein phosphatase binding|protein-macromolecule adaptor activity|positive regulation of actin filament polymerization|T cell costimulation|actin cytoskeleton reorganization|receptor internalization|entry of bacterium into host cell|interleukin-15-mediated signaling pathway|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|signal transduction in response to DNA damage|identical protein binding|regulation of MAPK cascade|insulin receptor substrate binding|protein-containing complex binding|positive regulation of Ras protein signal transduction|ephrin receptor binding|neurotrophin TRK receptor signaling pathway|anatomical structure formation involved in morphogenesis|leukocyte migration|positive regulation of protein kinase B signaling|branching involved in labyrinthine layer morphogenesis|membrane organization|extracellular exosome|Grb2-EGFR complex|cellular response to ionizing radiation|positive regulation of reactive oxygen species metabolic process "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04062,hsa04068,hsa04072,hsa04150,hsa04151,hsa04380,hsa04510,hsa04540,hsa04550,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04722,hsa04910,hsa04912,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05231" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Osteoclast differentiation|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer" GRB7 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.019238001 0.058438994 2886 growth factor receptor bound protein 7 "GO:0003723,GO:0005515,GO:0005829,GO:0005886,GO:0005925,GO:0007173,GO:0007411,GO:0008286,GO:0010494,GO:0017148,GO:0019901,GO:0030335,GO:0034063,GO:0035091,GO:0038128,GO:0042802,GO:0042995,GO:0046627,GO:0050900" RNA binding|protein binding|cytosol|plasma membrane|focal adhesion|epidermal growth factor receptor signaling pathway|axon guidance|insulin receptor signaling pathway|cytoplasmic stress granule|negative regulation of translation|protein kinase binding|positive regulation of cell migration|stress granule assembly|phosphatidylinositol binding|ERBB2 signaling pathway|identical protein binding|cell projection|negative regulation of insulin receptor signaling pathway|leukocyte migration GREB1 9.419395061 4.059823873 14.77896625 3.640297389 1.864056314 0.210034457 1 0.013542499 0.051422312 9687 growth regulating estrogen receptor binding 1 "GO:0005654,GO:0007275,GO:0016021,GO:0070062" nucleoplasm|multicellular organism development|integral component of membrane|extracellular exosome GREB1L 136.51034 104.5404647 168.4802152 1.611626805 0.688517706 0.260917354 1 0.389337874 0.654496102 80000 GREB1 like retinoic acid receptor coactivator "GO:0001822,GO:0007275,GO:0016021" kidney development|multicellular organism development|integral component of membrane GREM1 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.013898591 0.014073182 26585 "gremlin 1, DAN family BMP antagonist" "GO:0000902,GO:0002042,GO:0002092,GO:0003257,GO:0003337,GO:0005125,GO:0005515,GO:0005615,GO:0006915,GO:0007165,GO:0007171,GO:0007267,GO:0008284,GO:0009887,GO:0009954,GO:0009986,GO:0010717,GO:0016015,GO:0030199,GO:0030297,GO:0030308,GO:0030326,GO:0030502,GO:0030514,GO:0032331,GO:0032872,GO:0033689,GO:0036122,GO:0038098,GO:0042803,GO:0043066,GO:0043184,GO:0045668,GO:0045766,GO:0045892,GO:0045944,GO:0046851,GO:0048018,GO:0048263,GO:0051092,GO:0051893,GO:0051973,GO:0060173,GO:0060394,GO:0060676,GO:0061098,GO:0062023,GO:0072331,GO:0090027,GO:0090090,GO:0090190,GO:0090291,GO:1900086,GO:1900155,GO:1900158,GO:1901224,GO:2000273,GO:2000727" "cell morphogenesis|cell migration involved in sprouting angiogenesis|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|cytokine activity|protein binding|extracellular space|apoptotic process|signal transduction|activation of transmembrane receptor protein tyrosine kinase activity|cell-cell signaling|positive regulation of cell population proliferation|animal organ morphogenesis|proximal/distal pattern formation|cell surface|regulation of epithelial to mesenchymal transition|morphogen activity|collagen fibril organization|transmembrane receptor protein tyrosine kinase activator activity|negative regulation of cell growth|embryonic limb morphogenesis|negative regulation of bone mineralization|negative regulation of BMP signaling pathway|negative regulation of chondrocyte differentiation|regulation of stress-activated MAPK cascade|negative regulation of osteoblast proliferation|BMP binding|sequestering of BMP from receptor via BMP binding|protein homodimerization activity|negative regulation of apoptotic process|vascular endothelial growth factor receptor 2 binding|negative regulation of osteoblast differentiation|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of bone remodeling|receptor ligand activity|determination of dorsal identity|positive regulation of NF-kappaB transcription factor activity|regulation of focal adhesion assembly|positive regulation of telomerase activity|limb development|negative regulation of pathway-restricted SMAD protein phosphorylation|ureteric bud formation|positive regulation of protein tyrosine kinase activity|collagen-containing extracellular matrix|signal transduction by p53 class mediator|negative regulation of monocyte chemotaxis|negative regulation of canonical Wnt signaling pathway|positive regulation of branching involved in ureteric bud morphogenesis|negative regulation of osteoclast proliferation|positive regulation of peptidyl-tyrosine autophosphorylation|negative regulation of bone trabecula formation|negative regulation of bone mineralization involved in bone maturation|positive regulation of NIK/NF-kappaB signaling|positive regulation of signaling receptor activity|positive regulation of cardiac muscle cell differentiation" hsa04350 TGF-beta signaling pathway GRHL1 26.09193966 32.47859099 19.70528833 0.606716232 -0.720906186 0.494172706 1 0.436551501 0.2762721 29841 grainyhead like transcription factor 1 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0002934,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008544,GO:0019216,GO:0031490,GO:0042803,GO:0043231,GO:0043565,GO:0045616,GO:0045944,GO:0061436,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|desmosome organization|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|epidermis development|regulation of lipid metabolic process|chromatin DNA binding|protein homodimerization activity|intracellular membrane-bounded organelle|sequence-specific DNA binding|regulation of keratinocyte differentiation|positive regulation of transcription by RNA polymerase II|establishment of skin barrier|sequence-specific double-stranded DNA binding" CP2 GRHPR 2556.326189 2597.272323 2515.380055 0.968469896 -0.046220891 0.885865038 1 41.98617317 42.41391364 9380 glyoxylate and hydroxypyruvate reductase "GO:0005737,GO:0005782,GO:0005829,GO:0007588,GO:0008465,GO:0016618,GO:0030267,GO:0034641,GO:0042803,GO:0046487,GO:0051287,GO:0055114,GO:0070062,GO:0070402,GO:1902494" cytoplasm|peroxisomal matrix|cytosol|excretion|glycerate dehydrogenase activity|hydroxypyruvate reductase activity|glyoxylate reductase (NADP+) activity|cellular nitrogen compound metabolic process|protein homodimerization activity|glyoxylate metabolic process|NAD binding|oxidation-reduction process|extracellular exosome|NADPH binding|catalytic complex "hsa00260,hsa00620,hsa00630" "Glycine, serine and threonine metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism" GRID1 4.044978098 7.104691779 0.985264417 0.138677996 -2.850189203 0.227217187 1 0.061466958 0.008891299 2894 glutamate ionotropic receptor delta type subunit 1 "GO:0004970,GO:0005886,GO:0008066,GO:0015276,GO:0034220,GO:0035176,GO:0035235,GO:0035249,GO:0038023,GO:0045211,GO:0050804,GO:0060078,GO:0070062,GO:0098978,GO:0099061,GO:1904315" "ionotropic glutamate receptor activity|plasma membrane|glutamate receptor activity|ligand-gated ion channel activity|ion transmembrane transport|social behavior|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|signaling receptor activity|postsynaptic membrane|modulation of chemical synaptic transmission|regulation of postsynaptic membrane potential|extracellular exosome|glutamatergic synapse|integral component of postsynaptic density membrane|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" hsa04080 Neuroactive ligand-receptor interaction GRID2IP 7.448866228 4.059823873 10.83790858 2.669551419 1.416597337 0.391522599 1 0.043342276 0.120688512 392862 Grid2 interacting protein "GO:0045211,GO:0060292" postsynaptic membrane|long-term synaptic depression GRIK2 27.73586142 10.14955968 45.32216316 4.465431464 2.15879958 0.039921373 0.918666035 0.035258892 0.16422831 2898 glutamate ionotropic receptor kainate type subunit 2 "GO:0001662,GO:0005234,GO:0005886,GO:0005887,GO:0006874,GO:0007215,GO:0007268,GO:0008066,GO:0014069,GO:0015276,GO:0015277,GO:0019228,GO:0030165,GO:0031624,GO:0031625,GO:0032839,GO:0032983,GO:0034220,GO:0035235,GO:0035249,GO:0038023,GO:0042734,GO:0042802,GO:0043113,GO:0043195,GO:0043204,GO:0043524,GO:0043525,GO:0045211,GO:0046328,GO:0048169,GO:0048172,GO:0050804,GO:0050806,GO:0051402,GO:0051967,GO:0060079,GO:0060080,GO:0098686,GO:0098978,GO:0099505,GO:0099507,GO:0120169,GO:1904315" "behavioral fear response|extracellularly glutamate-gated ion channel activity|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|glutamate receptor signaling pathway|chemical synaptic transmission|glutamate receptor activity|postsynaptic density|ligand-gated ion channel activity|kainate selective glutamate receptor activity|neuronal action potential|PDZ domain binding|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|dendrite cytoplasm|kainate selective glutamate receptor complex|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|signaling receptor activity|presynaptic membrane|identical protein binding|receptor clustering|terminal bouton|perikaryon|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|postsynaptic membrane|regulation of JNK cascade|regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|modulation of chemical synaptic transmission|positive regulation of synaptic transmission|neuron apoptotic process|negative regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|inhibitory postsynaptic potential|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|regulation of presynaptic membrane potential|ligand-gated ion channel activity involved in regulation of presynaptic membrane potential|detection of cold stimulus involved in thermoception|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" "hsa04080,hsa04724" Neuroactive ligand-receptor interaction|Glutamatergic synapse GRIK4 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.005675603 0.017240697 2900 glutamate ionotropic receptor kainate type subunit 4 "GO:0005886,GO:0005887,GO:0007215,GO:0007268,GO:0008066,GO:0015276,GO:0015277,GO:0032983,GO:0034220,GO:0035235,GO:0035249,GO:0038023,GO:0042734,GO:0045211,GO:0050804,GO:0060078,GO:0098686,GO:0099055,GO:0099056,GO:1904315" "plasma membrane|integral component of plasma membrane|glutamate receptor signaling pathway|chemical synaptic transmission|glutamate receptor activity|ligand-gated ion channel activity|kainate selective glutamate receptor activity|kainate selective glutamate receptor complex|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|signaling receptor activity|presynaptic membrane|postsynaptic membrane|modulation of chemical synaptic transmission|regulation of postsynaptic membrane potential|hippocampal mossy fiber to CA3 synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" "hsa04080,hsa04724" Neuroactive ligand-receptor interaction|Glutamatergic synapse GRIK5 7.956344212 5.074779842 10.83790858 2.135641135 1.094669242 0.504649292 1 0.032135496 0.071586184 2901 glutamate ionotropic receptor kainate type subunit 5 "GO:0005654,GO:0005783,GO:0005886,GO:0006621,GO:0008066,GO:0015276,GO:0015277,GO:0017124,GO:0030165,GO:0030425,GO:0031630,GO:0032983,GO:0034220,GO:0035235,GO:0035249,GO:0038023,GO:0042802,GO:0043113,GO:0043195,GO:0043204,GO:0043525,GO:0045211,GO:0050804,GO:0051649,GO:0060079,GO:0071333,GO:0098686,GO:0098978,GO:0099056,GO:0099061,GO:1904315" "nucleoplasm|endoplasmic reticulum|plasma membrane|protein retention in ER lumen|glutamate receptor activity|ligand-gated ion channel activity|kainate selective glutamate receptor activity|SH3 domain binding|PDZ domain binding|dendrite|regulation of synaptic vesicle fusion to presynaptic active zone membrane|kainate selective glutamate receptor complex|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|signaling receptor activity|identical protein binding|receptor clustering|terminal bouton|perikaryon|positive regulation of neuron apoptotic process|postsynaptic membrane|modulation of chemical synaptic transmission|establishment of localization in cell|excitatory postsynaptic potential|cellular response to glucose stimulus|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|integral component of presynaptic membrane|integral component of postsynaptic density membrane|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" "hsa04080,hsa04724" Neuroactive ligand-receptor interaction|Glutamatergic synapse GRIN2D 870.1310022 818.0545105 922.2074939 1.127317901 0.17289441 0.63384515 1 7.20925266 8.477202928 2906 glutamate ionotropic receptor NMDA type subunit 2D "GO:0001964,GO:0004970,GO:0004972,GO:0005515,GO:0005886,GO:0005887,GO:0007420,GO:0008344,GO:0015276,GO:0017146,GO:0019722,GO:0022849,GO:0035235,GO:0038023,GO:0048167,GO:0051930,GO:0060079,GO:0060291,GO:0097553,GO:0098839,GO:0098976" startle response|ionotropic glutamate receptor activity|NMDA glutamate receptor activity|protein binding|plasma membrane|integral component of plasma membrane|brain development|adult locomotory behavior|ligand-gated ion channel activity|NMDA selective glutamate receptor complex|calcium-mediated signaling|glutamate-gated calcium ion channel activity|ionotropic glutamate receptor signaling pathway|signaling receptor activity|regulation of synaptic plasticity|regulation of sensory perception of pain|excitatory postsynaptic potential|long-term synaptic potentiation|calcium ion transmembrane import into cytosol|postsynaptic density membrane|excitatory chemical synaptic transmission "hsa04020,hsa04024,hsa04080,hsa04713,hsa04720,hsa04724,hsa05010,hsa05014,hsa05017,hsa05020,hsa05022,hsa05030,hsa05031,hsa05033,hsa05034" Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Long-term potentiation|Glutamatergic synapse|Alzheimer disease|Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction|Amphetamine addiction|Nicotine addiction|Alcoholism GRIN3B 234.0351876 305.5017465 162.5686287 0.532136495 -0.910131744 0.076433733 1 3.996019038 2.218025442 116444 glutamate ionotropic receptor NMDA type subunit 3B "GO:0004972,GO:0005261,GO:0005262,GO:0005886,GO:0015276,GO:0016594,GO:0017146,GO:0030594,GO:0035235,GO:0038023,GO:0042165,GO:0043025,GO:0045211,GO:0051205,GO:0051924,GO:0070588" NMDA glutamate receptor activity|cation channel activity|calcium channel activity|plasma membrane|ligand-gated ion channel activity|glycine binding|NMDA selective glutamate receptor complex|neurotransmitter receptor activity|ionotropic glutamate receptor signaling pathway|signaling receptor activity|neurotransmitter binding|neuronal cell body|postsynaptic membrane|protein insertion into membrane|regulation of calcium ion transport|calcium ion transmembrane transport "hsa04024,hsa04080,hsa04724,hsa05017,hsa05020,hsa05030,hsa05031,hsa05033,hsa05034" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Glutamatergic synapse|Spinocerebellar ataxia|Prion disease|Cocaine addiction|Amphetamine addiction|Nicotine addiction|Alcoholism GRINA 5887.38816 6058.272175 5716.504145 0.943586551 -0.08377324 0.79628384 1 165.1399964 162.5361404 2907 glutamate ionotropic receptor NMDA type subunit associated protein 1 "GO:0005515,GO:0005783,GO:0005794,GO:0016021,GO:0032469,GO:0044325,GO:1902236" protein binding|endoplasmic reticulum|Golgi apparatus|integral component of membrane|endoplasmic reticulum calcium ion homeostasis|ion channel binding|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GRIP2 7.448866228 4.059823873 10.83790858 2.669551419 1.416597337 0.391522599 1 0.016545889 0.046072769 80852 glutamate receptor interacting protein 2 "GO:0005829,GO:0005886,GO:0030159,GO:0098887" "cytosol|plasma membrane|signaling receptor complex adaptor activity|neurotransmitter receptor transport, endosome to postsynaptic membrane" GRIPAP1 1316.301636 1245.350973 1387.252298 1.113944846 0.155677804 0.645527743 1 20.80918293 24.17879462 56850 GRIP1 associated protein 1 "GO:0003674,GO:0005515,GO:0005654,GO:0005829,GO:0008150,GO:0030424,GO:0030425,GO:0042802,GO:0043231,GO:0055038,GO:0072562,GO:0098837,GO:0098887,GO:0098978,GO:0098998,GO:0099152,GO:0099158,GO:1905244" "molecular_function|protein binding|nucleoplasm|cytosol|biological_process|axon|dendrite|identical protein binding|intracellular membrane-bounded organelle|recycling endosome membrane|blood microparticle|postsynaptic recycling endosome|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|extrinsic component of postsynaptic early endosome membrane|regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane|regulation of recycling endosome localization within postsynapse|regulation of modification of synaptic structure" GRK2 2268.444395 2113.138326 2423.750465 1.146990916 0.197853966 0.536710398 1 29.92813241 35.80597671 156 G protein-coupled receptor kinase 2 "GO:0002029,GO:0003108,GO:0004672,GO:0004703,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005929,GO:0007186,GO:0007213,GO:0007217,GO:0007507,GO:0016020,GO:0018105,GO:0018107,GO:0019079,GO:0031623,GO:0031694,GO:0031755,GO:0033605,GO:0045202,GO:0045988,GO:0046718,GO:0047696,GO:0060048,GO:1901081" desensitization of G protein-coupled receptor signaling pathway|negative regulation of the force of heart contraction by chemical signal|protein kinase activity|G protein-coupled receptor kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|cilium|G protein-coupled receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|tachykinin receptor signaling pathway|heart development|membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|viral genome replication|receptor internalization|alpha-2A adrenergic receptor binding|Edg-2 lysophosphatidic acid receptor binding|positive regulation of catecholamine secretion|synapse|negative regulation of striated muscle contraction|viral entry into host cell|beta-adrenergic receptor kinase activity|cardiac muscle contraction|negative regulation of relaxation of smooth muscle "hsa04062,hsa04144,hsa04340,hsa04724,hsa04740,hsa05032" Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Glutamatergic synapse|Olfactory transduction|Morphine addiction GRK3 204.7405197 188.7818101 220.6992293 1.169070416 0.22536183 0.678819065 1 1.94608848 2.373117173 157 G protein-coupled receptor kinase 3 "GO:0004672,GO:0004703,GO:0005515,GO:0005524,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0007186,GO:0031623,GO:0047696" protein kinase activity|G protein-coupled receptor kinase activity|protein binding|ATP binding|cytosol|plasma membrane|protein phosphorylation|signal transduction|G protein-coupled receptor signaling pathway|receptor internalization|beta-adrenergic receptor kinase activity "hsa04062,hsa04144,hsa04340,hsa04724,hsa04740,hsa05032" Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Glutamatergic synapse|Olfactory transduction|Morphine addiction GRK4 27.01782097 28.41876711 25.61687483 0.901406973 -0.149749485 0.91966446 1 0.406125931 0.381854192 2868 G protein-coupled receptor kinase 4 "GO:0002031,GO:0004703,GO:0005524,GO:0005829,GO:0005938,GO:0006468,GO:0007165,GO:0008277,GO:0022400,GO:0030425,GO:0031623,GO:0043025,GO:0050254,GO:0097381" G protein-coupled receptor internalization|G protein-coupled receptor kinase activity|ATP binding|cytosol|cell cortex|protein phosphorylation|signal transduction|regulation of G protein-coupled receptor signaling pathway|regulation of rhodopsin mediated signaling pathway|dendrite|receptor internalization|neuronal cell body|rhodopsin kinase activity|photoreceptor disc membrane "hsa04062,hsa04144,hsa05032" Chemokine signaling pathway|Endocytosis|Morphine addiction GRK5 280.8825063 275.0530674 286.7119452 1.04238774 0.05989202 0.908610896 1 5.213498329 5.668582387 2869 G protein-coupled receptor kinase 5 "GO:0004674,GO:0004703,GO:0005080,GO:0005515,GO:0005524,GO:0005543,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0007186,GO:0007188,GO:0007217,GO:0008277,GO:0008284,GO:0016055,GO:0016607,GO:0031965,GO:0043066,GO:0046777,GO:0047696,GO:0051726" protein serine/threonine kinase activity|G protein-coupled receptor kinase activity|protein kinase C binding|protein binding|ATP binding|phospholipid binding|cytoplasm|cytosol|plasma membrane|apoptotic process|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|tachykinin receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|positive regulation of cell population proliferation|Wnt signaling pathway|nuclear speck|nuclear membrane|negative regulation of apoptotic process|protein autophosphorylation|beta-adrenergic receptor kinase activity|regulation of cell cycle "hsa04062,hsa04144,hsa05032" Chemokine signaling pathway|Endocytosis|Morphine addiction GRK6 1123.894489 1024.090572 1223.698405 1.194912285 0.256904718 0.457737993 1 13.23126906 16.49124549 2870 G protein-coupled receptor kinase 6 "GO:0004703,GO:0005515,GO:0005524,GO:0005886,GO:0006468,GO:0007186,GO:0008277,GO:0016020,GO:0016055,GO:0047696" G protein-coupled receptor kinase activity|protein binding|ATP binding|plasma membrane|protein phosphorylation|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|membrane|Wnt signaling pathway|beta-adrenergic receptor kinase activity "hsa04062,hsa04144,hsa05032" Chemokine signaling pathway|Endocytosis|Morphine addiction GRK7 2.95579325 0 5.911586499 Inf Inf 0.136075969 1 0 0.04797941 131890 G protein-coupled receptor kinase 7 "GO:0004703,GO:0005524,GO:0007165,GO:0007601,GO:0022400,GO:0046777,GO:0050254,GO:0097381" G protein-coupled receptor kinase activity|ATP binding|signal transduction|visual perception|regulation of rhodopsin mediated signaling pathway|protein autophosphorylation|rhodopsin kinase activity|photoreceptor disc membrane "hsa04062,hsa04144,hsa04744" Chemokine signaling pathway|Endocytosis|Phototransduction GRN 11019.9309 10996.03296 11043.82885 1.004346648 0.006257298 0.985584602 1 220.2967871 230.7850793 2896 granulin precursor "GO:0002265,GO:0002282,GO:0003723,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005765,GO:0005768,GO:0005770,GO:0005783,GO:0005794,GO:0005802,GO:0005886,GO:0007040,GO:0007041,GO:0007042,GO:0007165,GO:0008083,GO:0010595,GO:0016020,GO:0030335,GO:0035578,GO:0043312,GO:0043524,GO:0043525,GO:0045766,GO:0048680,GO:0050679,GO:0050727,GO:0050821,GO:0051087,GO:0060266,GO:0070062,GO:0106016,GO:1900426,GO:1902564,GO:1903334,GO:1903979,GO:1905247,GO:1905673" astrocyte activation involved in immune response|microglial cell activation involved in immune response|RNA binding|cytokine activity|protein binding|extracellular region|extracellular space|lysosome|lysosomal membrane|endosome|late endosome|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|plasma membrane|lysosome organization|lysosomal transport|lysosomal lumen acidification|signal transduction|growth factor activity|positive regulation of endothelial cell migration|membrane|positive regulation of cell migration|azurophil granule lumen|neutrophil degranulation|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|positive regulation of angiogenesis|positive regulation of axon regeneration|positive regulation of epithelial cell proliferation|regulation of inflammatory response|protein stabilization|chaperone binding|negative regulation of respiratory burst involved in inflammatory response|extracellular exosome|positive regulation of inflammatory response to wounding|positive regulation of defense response to bacterium|negative regulation of neutrophil activation|positive regulation of protein folding|negative regulation of microglial cell activation|positive regulation of aspartic-type peptidase activity|positive regulation of lysosome organization GRPEL1 766.6727953 885.0416044 648.3039861 0.732512441 -0.449074832 0.225670544 1 16.89567849 12.90941527 80273 "GrpE like 1, mitochondrial" "GO:0000774,GO:0001405,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0006457,GO:0030150,GO:0042802,GO:0042803,GO:0050790,GO:0051082,GO:0051087" "adenyl-nucleotide exchange factor activity|PAM complex, Tim23 associated import motor|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|protein folding|protein import into mitochondrial matrix|identical protein binding|protein homodimerization activity|regulation of catalytic activity|unfolded protein binding|chaperone binding" GRPEL2 470.5174527 441.5058462 499.5290592 1.131421166 0.178136065 0.670583547 1 5.56236656 6.564472512 134266 "GrpE like 2, mitochondrial" "GO:0000774,GO:0001405,GO:0005739,GO:0006457,GO:0030150,GO:0042803,GO:0050790,GO:0051082,GO:0051087" "adenyl-nucleotide exchange factor activity|PAM complex, Tim23 associated import motor|mitochondrion|protein folding|protein import into mitochondrial matrix|protein homodimerization activity|regulation of catalytic activity|unfolded protein binding|chaperone binding" GRPR 21.10623447 28.41876711 13.79370183 0.485372985 -1.042834281 0.347620678 1 0.595494538 0.301487502 2925 gastrin releasing peptide receptor "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007200,GO:0007218,GO:0007611,GO:0008188,GO:0008528,GO:0035176,GO:0036343,GO:0042127,GO:0042923,GO:0043207,GO:0061744" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|learning or memory|neuropeptide receptor activity|G protein-coupled peptide receptor activity|social behavior|psychomotor behavior|regulation of cell population proliferation|neuropeptide binding|response to external biotic stimulus|motor behavior "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction GRSF1 1788.919024 1931.461208 1646.37684 0.852399641 -0.230398109 0.478970813 1 14.49425047 12.88709261 2926 G-rich RNA sequence binding factor 1 "GO:0000962,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0006378,GO:0008033,GO:0009952,GO:0016331,GO:0035770,GO:0042645,GO:0043484,GO:1990904" positive regulation of mitochondrial RNA catabolic process|RNA binding|mRNA binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|mRNA polyadenylation|tRNA processing|anterior/posterior pattern specification|morphogenesis of embryonic epithelium|ribonucleoprotein granule|mitochondrial nucleoid|regulation of RNA splicing|ribonucleoprotein complex GRTP1 16.47954951 15.22433953 17.7347595 1.164895165 0.220200125 0.902537541 1 0.132598296 0.161116758 79774 growth hormone regulated TBC protein 1 "GO:0005096,GO:0006886,GO:0090630" GTPase activator activity|intracellular protein transport|activation of GTPase activity GRWD1 803.8577433 901.2808999 706.4345867 0.78381178 -0.351420839 0.338562949 1 8.514586468 6.961314844 83743 glutamate rich WD repeat containing 1 "GO:0003682,GO:0003688,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006260,GO:0006334,GO:0006337,GO:0032991,GO:0042393" chromatin binding|DNA replication origin binding|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|DNA replication|nucleosome assembly|nucleosome disassembly|protein-containing complex|histone binding GSAP 258.687087 239.5296085 277.8445655 1.159959168 0.214074022 0.670287807 1 3.421130757 4.139313357 54103 gamma-secretase activating protein "GO:0001540,GO:0005515,GO:0005802,GO:0030162,GO:1902004" amyloid-beta binding|protein binding|trans-Golgi network|regulation of proteolysis|positive regulation of amyloid-beta formation GSDMA 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.025359615 0.128390882 284110 gasdermin A "GO:0001786,GO:0005515,GO:0005546,GO:0005829,GO:0005886,GO:0006915,GO:0016021,GO:0042742,GO:0048471,GO:0070269,GO:0070273" "phosphatidylserine binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|apoptotic process|integral component of membrane|defense response to bacterium|perinuclear region of cytoplasm|pyroptosis|phosphatidylinositol-4-phosphate binding" GSDMB 88.82893621 111.6451565 66.01271591 0.591272546 -0.758104804 0.28344317 1 2.028860178 1.251283627 55876 gasdermin B "GO:0001786,GO:0003674,GO:0005546,GO:0005575,GO:0005737,GO:0005886,GO:0016021,GO:0019835,GO:0042742,GO:0070269,GO:0070273" "phosphatidylserine binding|molecular_function|phosphatidylinositol-4,5-bisphosphate binding|cellular_component|cytoplasm|plasma membrane|integral component of membrane|cytolysis|defense response to bacterium|pyroptosis|phosphatidylinositol-4-phosphate binding" GSDMC 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.046071198 0 56169 gasdermin C "GO:0001786,GO:0003674,GO:0005546,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016021,GO:0042742,GO:0070269,GO:0070273" "phosphatidylserine binding|molecular_function|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|plasma membrane|biological_process|integral component of membrane|defense response to bacterium|pyroptosis|phosphatidylinositol-4-phosphate binding" GSDMD 1143.68613 1063.673855 1223.698405 1.150445129 0.202192175 0.558234391 1 23.10091266 27.72113307 79792 gasdermin D "GO:0001786,GO:0005515,GO:0005546,GO:0005576,GO:0005615,GO:0005654,GO:0005829,GO:0005886,GO:0006954,GO:0016021,GO:0032731,GO:0035580,GO:0035915,GO:0042742,GO:0043312,GO:0045087,GO:0046931,GO:0050829,GO:0050830,GO:0051260,GO:0070269,GO:0070273,GO:0070300,GO:0072559,GO:1901612,GO:1904724,GO:1904813" "phosphatidylserine binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|extracellular space|nucleoplasm|cytosol|plasma membrane|inflammatory response|integral component of membrane|positive regulation of interleukin-1 beta production|specific granule lumen|pore formation in membrane of other organism|defense response to bacterium|neutrophil degranulation|innate immune response|pore complex assembly|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|protein homooligomerization|pyroptosis|phosphatidylinositol-4-phosphate binding|phosphatidic acid binding|NLRP3 inflammasome complex|cardiolipin binding|tertiary granule lumen|ficolin-1-rich granule lumen" "hsa04621,hsa05132" NOD-like receptor signaling pathway|Salmonella infection GSDME 1445.088959 1596.525738 1293.652179 0.810292091 -0.303486036 0.362418806 1 29.95865003 25.32093681 1687 gasdermin E "GO:0005515,GO:0005546,GO:0005829,GO:0005886,GO:0007605,GO:0008219,GO:0008285,GO:0016020,GO:0016021,GO:0043410,GO:0060113,GO:0070265,GO:0070269,GO:0071356,GO:0098586,GO:1901612,GO:2001244" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|sensory perception of sound|cell death|negative regulation of cell population proliferation|membrane|integral component of membrane|positive regulation of MAPK cascade|inner ear receptor cell differentiation|necrotic cell death|pyroptosis|cellular response to tumor necrosis factor|cellular response to virus|cardiolipin binding|positive regulation of intrinsic apoptotic signaling pathway" GSE1 351.8200605 477.0293051 226.6108158 0.4750459 -1.073861177 0.017832693 0.578240013 1.659672422 0.822382541 23199 Gse1 coiled-coil protein GO:0005515 protein binding GSK3A 1389.988626 1231.14159 1548.835663 1.258048364 0.331187386 0.322760398 1 28.43273065 37.31056605 2931 glycogen synthase kinase 3 alpha "GO:0003073,GO:0003214,GO:0004674,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0005977,GO:0006349,GO:0006468,GO:0007165,GO:0007212,GO:0007399,GO:0007568,GO:0008286,GO:0010508,GO:0010628,GO:0010800,GO:0010905,GO:0010975,GO:0016055,GO:0016477,GO:0018105,GO:0018107,GO:0030424,GO:0030877,GO:0031398,GO:0032007,GO:0032436,GO:0032869,GO:0033138,GO:0034236,GO:0036016,GO:0036498,GO:0043025,GO:0043161,GO:0043525,GO:0044027,GO:0045719,GO:0045732,GO:0045823,GO:0045944,GO:0046325,GO:0046627,GO:0048156,GO:0050321,GO:0060079,GO:0061052,GO:0071285,GO:0071879,GO:0090090,GO:0097191,GO:0097192,GO:0097440,GO:0098794,GO:0106071,GO:0106310,GO:0106311,GO:1901030,GO:1902004,GO:1903146,GO:1903955,GO:1904227,GO:1990635,GO:2000077,GO:2000171,GO:2000466,GO:2000467" "regulation of systemic arterial blood pressure|cardiac left ventricle morphogenesis|protein serine/threonine kinase activity|signaling receptor binding|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|cytosol|microtubule|glycogen metabolic process|regulation of gene expression by genetic imprinting|protein phosphorylation|signal transduction|dopamine receptor signaling pathway|nervous system development|aging|insulin receptor signaling pathway|positive regulation of autophagy|positive regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|negative regulation of UDP-glucose catabolic process|regulation of neuron projection development|Wnt signaling pathway|cell migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|axon|beta-catenin destruction complex|positive regulation of protein ubiquitination|negative regulation of TOR signaling|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to insulin stimulus|positive regulation of peptidyl-serine phosphorylation|protein kinase A catalytic subunit binding|cellular response to interleukin-3|IRE1-mediated unfolded protein response|neuronal cell body|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of neuron apoptotic process|hypermethylation of CpG island|negative regulation of glycogen biosynthetic process|positive regulation of protein catabolic process|positive regulation of heart contraction|positive regulation of transcription by RNA polymerase II|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|tau protein binding|tau-protein kinase activity|excitatory postsynaptic potential|negative regulation of cell growth involved in cardiac muscle cell development|cellular response to lithium ion|positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway|negative regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|apical dendrite|postsynapse|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|protein serine kinase activity|protein threonine kinase activity|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of amyloid-beta formation|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|negative regulation of glycogen synthase activity, transferring glucose-1-phosphate|proximal dendrite|negative regulation of type B pancreatic cell development|negative regulation of dendrite development|negative regulation of glycogen (starch) synthase activity|positive regulation of glycogen (starch) synthase activity" "hsa04062,hsa04728,hsa04932,hsa05131" Chemokine signaling pathway|Dopaminergic synapse|Non-alcoholic fatty liver disease|Shigellosis GSK3B 2390.373961 2534.345053 2246.40287 0.886383986 -0.173996278 0.586336869 1 18.01482615 16.65589239 2932 glycogen synthase kinase 3 beta "GO:0001085,GO:0001837,GO:0001954,GO:0002020,GO:0002039,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0005977,GO:0006468,GO:0006983,GO:0007165,GO:0007212,GO:0007623,GO:0008013,GO:0008286,GO:0010508,GO:0010628,GO:0010822,GO:0010975,GO:0016055,GO:0016301,GO:0018105,GO:0018107,GO:0019901,GO:0021766,GO:0030010,GO:0030011,GO:0030424,GO:0030425,GO:0030516,GO:0030877,GO:0031175,GO:0031333,GO:0031334,GO:0031625,GO:0032091,GO:0032092,GO:0032436,GO:0032515,GO:0032886,GO:0034236,GO:0034452,GO:0035556,GO:0036016,GO:0042752,GO:0043066,GO:0043547,GO:0045719,GO:0045732,GO:0046777,GO:0046827,GO:0048156,GO:0048814,GO:0050321,GO:0050770,GO:0051059,GO:0060079,GO:0070507,GO:0070885,GO:0071109,GO:0090090,GO:0097191,GO:0097192,GO:0098794,GO:0098978,GO:0106027,GO:0106310,GO:0106311,GO:0150101,GO:1900034,GO:1900181,GO:1900271,GO:1901030,GO:1901215,GO:1901216,GO:1901984,GO:1902042,GO:1904339,GO:1904646,GO:1904781,GO:1904885,GO:1904886,GO:1990909,GO:2000077,GO:2000300,GO:2000466" RNA polymerase II transcription factor binding|epithelial to mesenchymal transition|positive regulation of cell-matrix adhesion|protease binding|p53 binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|centrosome|cytosol|plasma membrane|glycogen metabolic process|protein phosphorylation|ER overload response|signal transduction|dopamine receptor signaling pathway|circadian rhythm|beta-catenin binding|insulin receptor signaling pathway|positive regulation of autophagy|positive regulation of gene expression|positive regulation of mitochondrion organization|regulation of neuron projection development|Wnt signaling pathway|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein kinase binding|hippocampus development|establishment of cell polarity|maintenance of cell polarity|axon|dendrite|regulation of axon extension|beta-catenin destruction complex|neuron projection development|negative regulation of protein-containing complex assembly|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|negative regulation of protein binding|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of phosphoprotein phosphatase activity|regulation of microtubule-based process|protein kinase A catalytic subunit binding|dynactin binding|intracellular signal transduction|cellular response to interleukin-3|regulation of circadian rhythm|negative regulation of apoptotic process|positive regulation of GTPase activity|negative regulation of glycogen biosynthetic process|positive regulation of protein catabolic process|protein autophosphorylation|positive regulation of protein export from nucleus|tau protein binding|regulation of dendrite morphogenesis|tau-protein kinase activity|regulation of axonogenesis|NF-kappaB binding|excitatory postsynaptic potential|regulation of microtubule cytoskeleton organization|negative regulation of calcineurin-NFAT signaling cascade|superior temporal gyrus development|negative regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|postsynapse|glutamatergic synapse|neuron projection organization|protein serine kinase activity|protein threonine kinase activity|regulation of microtubule anchoring at centrosome|regulation of cellular response to heat|negative regulation of protein localization to nucleus|regulation of long-term synaptic potentiation|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|negative regulation of neuron death|positive regulation of neuron death|negative regulation of protein acetylation|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of dopaminergic neuron differentiation|cellular response to amyloid-beta|positive regulation of protein localization to centrosome|beta-catenin destruction complex assembly|beta-catenin destruction complex disassembly|Wnt signalosome|negative regulation of type B pancreatic cell development|regulation of synaptic vesicle exocytosis|negative regulation of glycogen (starch) synthase activity "hsa01521,hsa04012,hsa04062,hsa04110,hsa04150,hsa04151,hsa04310,hsa04340,hsa04360,hsa04390,hsa04510,hsa04550,hsa04657,hsa04660,hsa04662,hsa04722,hsa04728,hsa04910,hsa04916,hsa04917,hsa04919,hsa04931,hsa04932,hsa04934,hsa04935,hsa05010,hsa05020,hsa05022,hsa05131,hsa05135,hsa05160,hsa05162,hsa05163,hsa05165,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05217,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Chemokine signaling pathway|Cell cycle|mTOR signaling pathway|PI3K-Akt signaling pathway|Wnt signaling pathway|Hedgehog signaling pathway|Axon guidance|Hippo signaling pathway|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|IL-17 signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Neurotrophin signaling pathway|Dopaminergic synapse|Insulin signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Cushing syndrome|Growth hormone synthesis, secretion and action|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Yersinia infection|Hepatitis C|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer" GSKIP 533.2801815 387.7131799 678.847183 1.750900455 0.808097063 0.045136246 0.96408227 7.267322277 13.27247161 51527 GSK3B interacting protein "GO:0004860,GO:0005515,GO:0005634,GO:0005737,GO:0006469,GO:0008013,GO:0008631,GO:0019207,GO:0019901,GO:0030111,GO:0034237,GO:0051018,GO:0090263" protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|negative regulation of protein kinase activity|beta-catenin binding|intrinsic apoptotic signaling pathway in response to oxidative stress|kinase regulator activity|protein kinase binding|regulation of Wnt signaling pathway|protein kinase A regulatory subunit binding|protein kinase A binding|positive regulation of canonical Wnt signaling pathway GSN 2575.283992 2243.05269 2907.515293 1.296231384 0.37432327 0.240598793 1 20.42112273 27.61074197 2934 gelsolin "GO:0001726,GO:0002102,GO:0003779,GO:0005509,GO:0005515,GO:0005546,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006911,GO:0007417,GO:0007568,GO:0008154,GO:0010628,GO:0014003,GO:0014891,GO:0015629,GO:0016528,GO:0022617,GO:0030027,GO:0030031,GO:0030041,GO:0030042,GO:0030155,GO:0030478,GO:0030864,GO:0031648,GO:0032991,GO:0034774,GO:0035994,GO:0036313,GO:0042060,GO:0042246,GO:0042989,GO:0043209,GO:0043312,GO:0044267,GO:0045010,GO:0045159,GO:0045335,GO:0045471,GO:0046597,GO:0048015,GO:0048471,GO:0051014,GO:0051015,GO:0051016,GO:0051127,GO:0051593,GO:0051693,GO:0055119,GO:0060271,GO:0070062,GO:0071276,GO:0071346,GO:0071801,GO:0072562,GO:0086003,GO:0090527,GO:0097017,GO:0097284,GO:1902174,GO:1903903,GO:1903906,GO:1903909,GO:1903923,GO:1904813,GO:1990000,GO:2001269" "ruffle|podosome|actin binding|calcium ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|phagocytosis, engulfment|central nervous system development|aging|actin polymerization or depolymerization|positive regulation of gene expression|oligodendrocyte development|striated muscle atrophy|actin cytoskeleton|sarcoplasm|extracellular matrix disassembly|lamellipodium|cell projection assembly|actin filament polymerization|actin filament depolymerization|regulation of cell adhesion|actin cap|cortical actin cytoskeleton|protein destabilization|protein-containing complex|secretory granule lumen|response to muscle stretch|phosphatidylinositol 3-kinase catalytic subunit binding|wound healing|tissue regeneration|sequestering of actin monomers|myelin sheath|neutrophil degranulation|cellular protein metabolic process|actin nucleation|myosin II binding|phagocytic vesicle|response to ethanol|negative regulation of viral entry into host cell|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|actin filament severing|actin filament binding|barbed-end actin filament capping|positive regulation of actin nucleation|response to folic acid|actin filament capping|relaxation of cardiac muscle|cilium assembly|extracellular exosome|cellular response to cadmium ion|cellular response to interferon-gamma|regulation of podosome assembly|blood microparticle|cardiac muscle cell contraction|actin filament reorganization|renal protein absorption|hepatocyte apoptotic process|positive regulation of keratinocyte apoptotic process|regulation of establishment of T cell polarity|regulation of plasma membrane raft polarization|regulation of receptor clustering|positive regulation of protein processing in phagocytic vesicle|ficolin-1-rich granule lumen|amyloid fibril formation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway" "hsa04666,hsa04810,hsa05203" Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Viral carcinogenesis GSPT1 3124.824749 3136.213942 3113.435556 0.99273698 -0.010516561 0.974725657 1 20.4846753 21.21188255 2935 G1 to S phase transition 1 "GO:0000082,GO:0000184,GO:0002184,GO:0003723,GO:0003747,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0006412,GO:0006449,GO:0006479,GO:0018444" "G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translational termination|RNA binding|translation release factor activity|GTPase activity|protein binding|GTP binding|cytosol|translation|regulation of translational termination|protein methylation|translation release factor complex" hsa03015 mRNA surveillance pathway GSR 776.2042756 795.7254792 756.6830719 0.950934828 -0.072581625 0.84734236 1 13.28302188 13.17539279 2936 glutathione-disulfide reductase "GO:0004362,GO:0005739,GO:0005759,GO:0005829,GO:0006749,GO:0009055,GO:0009897,GO:0015949,GO:0022900,GO:0034599,GO:0045454,GO:0050660,GO:0050661,GO:0070062,GO:0098869" glutathione-disulfide reductase activity|mitochondrion|mitochondrial matrix|cytosol|glutathione metabolic process|electron transfer activity|external side of plasma membrane|nucleobase-containing small molecule interconversion|electron transport chain|cellular response to oxidative stress|cell redox homeostasis|flavin adenine dinucleotide binding|NADP binding|extracellular exosome|cellular oxidant detoxification "hsa00480,hsa04918" Glutathione metabolism|Thyroid hormone synthesis GSS 2163.353153 2068.480264 2258.226043 1.091731975 0.126618711 0.693718886 1 35.07238975 39.93901212 2937 glutathione synthetase "GO:0000287,GO:0004363,GO:0005515,GO:0005524,GO:0005829,GO:0006520,GO:0006750,GO:0006979,GO:0007399,GO:0007568,GO:0009410,GO:0016594,GO:0031667,GO:0034612,GO:0042802,GO:0042803,GO:0043200,GO:0043295,GO:0046686,GO:0070062" magnesium ion binding|glutathione synthase activity|protein binding|ATP binding|cytosol|cellular amino acid metabolic process|glutathione biosynthetic process|response to oxidative stress|nervous system development|aging|response to xenobiotic stimulus|glycine binding|response to nutrient levels|response to tumor necrosis factor|identical protein binding|protein homodimerization activity|response to amino acid|glutathione binding|response to cadmium ion|extracellular exosome "hsa00270,hsa00480,hsa04216" Cysteine and methionine metabolism|Glutathione metabolism|Ferroptosis GSTA4 41.10843832 48.71788648 33.49899016 0.687611729 -0.540333941 0.55838685 1 1.988226498 1.426018184 2941 glutathione S-transferase alpha 4 "GO:0004364,GO:0005515,GO:0005829,GO:0006749,GO:0006805,GO:0042802,GO:0042803,GO:1901687" glutathione transferase activity|protein binding|cytosol|glutathione metabolic process|xenobiotic metabolic process|identical protein binding|protein homodimerization activity|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTCD 384.2177416 435.4161104 333.0193728 0.764830159 -0.386788682 0.378695494 1 4.663203624 3.720191654 79807 glutathione S-transferase C-terminal domain containing "GO:0003674,GO:0005515,GO:0005737,GO:0008150,GO:0070062" molecular_function|protein binding|cytoplasm|biological_process|extracellular exosome GSTK1 1101.183427 1088.032798 1114.334055 1.024173221 0.034459742 0.923473949 1 53.39633999 57.04280005 373156 glutathione S-transferase kappa 1 "GO:0004364,GO:0004602,GO:0005515,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006749,GO:0016020,GO:0030855,GO:0055114,GO:0070062,GO:0098869,GO:1901687" glutathione transferase activity|glutathione peroxidase activity|protein binding|mitochondrion|mitochondrial matrix|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|glutathione metabolic process|membrane|epithelial cell differentiation|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa04146,hsa05204" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Peroxisome|Chemical carcinogenesis GSTM2 9.000991732 9.134603715 8.867379749 0.970745971 -0.042834281 1 1 0.233300783 0.236231454 2946 glutathione S-transferase mu 2 "GO:0004364,GO:0004602,GO:0005102,GO:0005504,GO:0005515,GO:0005737,GO:0005829,GO:0006749,GO:0010880,GO:0010881,GO:0014809,GO:0016529,GO:0018916,GO:0019899,GO:0042178,GO:0042803,GO:0043295,GO:0043651,GO:0045171,GO:0051122,GO:0055119,GO:0060315,GO:0060316,GO:0070062,GO:0070458,GO:0071313,GO:0098869,GO:1901687" glutathione transferase activity|glutathione peroxidase activity|signaling receptor binding|fatty acid binding|protein binding|cytoplasm|cytosol|glutathione metabolic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|sarcoplasmic reticulum|nitrobenzene metabolic process|enzyme binding|xenobiotic catabolic process|protein homodimerization activity|glutathione binding|linoleic acid metabolic process|intercellular bridge|hepoxilin biosynthetic process|relaxation of cardiac muscle|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|extracellular exosome|cellular detoxification of nitrogen compound|cellular response to caffeine|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTM3 812.3000387 804.8600829 819.7399946 1.018487576 0.026428381 0.946019753 1 9.889210049 10.5059001 2947 glutathione S-transferase mu 3 "GO:0004364,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006749,GO:0008065,GO:0018916,GO:0019899,GO:0035686,GO:0042178,GO:0042802,GO:0042803,GO:0043295,GO:0043627,GO:0045171,GO:0070062,GO:0070458,GO:1901687" glutathione transferase activity|protein binding|nucleus|cytoplasm|cytosol|glutathione metabolic process|establishment of blood-nerve barrier|nitrobenzene metabolic process|enzyme binding|sperm fibrous sheath|xenobiotic catabolic process|identical protein binding|protein homodimerization activity|glutathione binding|response to estrogen|intercellular bridge|extracellular exosome|cellular detoxification of nitrogen compound|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTM4 233.8652031 192.841634 274.8887722 1.42546382 0.511431422 0.318929625 1 4.220721027 6.275650896 2948 glutathione S-transferase mu 4 "GO:0004364,GO:0004464,GO:0005515,GO:0005737,GO:0005829,GO:0006749,GO:0018916,GO:0019899,GO:0042178,GO:0042759,GO:0042803,GO:0043295,GO:0045171,GO:1901687" glutathione transferase activity|leukotriene-C4 synthase activity|protein binding|cytoplasm|cytosol|glutathione metabolic process|nitrobenzene metabolic process|enzyme binding|xenobiotic catabolic process|long-chain fatty acid biosynthetic process|protein homodimerization activity|glutathione binding|intercellular bridge|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTO1 3740.079078 3301.651765 4178.506391 1.265580591 0.339799379 0.285999818 1 146.6815916 193.6338805 9446 glutathione S-transferase omega 1 "GO:0004364,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006749,GO:0010880,GO:0010881,GO:0014810,GO:0016491,GO:0019852,GO:0032259,GO:0035722,GO:0042178,GO:0045174,GO:0050610,GO:0055114,GO:0060315,GO:0060316,GO:0070062,GO:0071243,GO:0098869,GO:1901687" glutathione transferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|glutathione metabolic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|oxidoreductase activity|L-ascorbic acid metabolic process|methylation|interleukin-12-mediated signaling pathway|xenobiotic catabolic process|glutathione dehydrogenase (ascorbate) activity|methylarsonate reductase activity|oxidation-reduction process|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|extracellular exosome|cellular response to arsenic-containing substance|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTO2 156.7473546 174.5724266 138.9222827 0.795785941 -0.329547684 0.576830256 1 0.869368491 0.721632506 119391 glutathione S-transferase omega 2 "GO:0004364,GO:0005515,GO:0005829,GO:0006749,GO:0006805,GO:0016491,GO:0019852,GO:0042802,GO:0045174,GO:0050610,GO:0055114,GO:0070062,GO:0071243,GO:0098869,GO:1901687" glutathione transferase activity|protein binding|cytosol|glutathione metabolic process|xenobiotic metabolic process|oxidoreductase activity|L-ascorbic acid metabolic process|identical protein binding|glutathione dehydrogenase (ascorbate) activity|methylarsonate reductase activity|oxidation-reduction process|extracellular exosome|cellular response to arsenic-containing substance|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTP1 6751.489056 6497.74811 7005.230002 1.078101195 0.108492602 0.740071541 1 444.1133861 499.4238987 2950 glutathione S-transferase pi 1 "GO:0000302,GO:0002674,GO:0004364,GO:0004602,GO:0005504,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006469,GO:0006693,GO:0006749,GO:0006805,GO:0007417,GO:0008144,GO:0008432,GO:0009890,GO:0010804,GO:0014003,GO:0019207,GO:0031100,GO:0031982,GO:0032355,GO:0032691,GO:0032720,GO:0032869,GO:0032872,GO:0032873,GO:0032930,GO:0033591,GO:0034599,GO:0034774,GO:0035726,GO:0035730,GO:0035731,GO:0035732,GO:0043066,GO:0043124,GO:0043200,GO:0043295,GO:0043312,GO:0043407,GO:0043409,GO:0043508,GO:0043651,GO:0045471,GO:0048147,GO:0051122,GO:0051771,GO:0070026,GO:0070062,GO:0070372,GO:0070373,GO:0070664,GO:0071222,GO:0071364,GO:0071385,GO:0071460,GO:0071638,GO:0071672,GO:0097057,GO:0098869,GO:1901687,GO:1904706,GO:1904813,GO:2001237" response to reactive oxygen species|negative regulation of acute inflammatory response|glutathione transferase activity|glutathione peroxidase activity|fatty acid binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|cytosol|plasma membrane|negative regulation of protein kinase activity|prostaglandin metabolic process|glutathione metabolic process|xenobiotic metabolic process|central nervous system development|drug binding|JUN kinase binding|negative regulation of biosynthetic process|negative regulation of tumor necrosis factor-mediated signaling pathway|oligodendrocyte development|kinase regulator activity|animal organ regeneration|vesicle|response to estradiol|negative regulation of interleukin-1 beta production|negative regulation of tumor necrosis factor production|cellular response to insulin stimulus|regulation of stress-activated MAPK cascade|negative regulation of stress-activated MAPK cascade|positive regulation of superoxide anion generation|response to L-ascorbic acid|cellular response to oxidative stress|secretory granule lumen|common myeloid progenitor cell proliferation|S-nitrosoglutathione binding|dinitrosyl-iron complex binding|nitric oxide storage|negative regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|response to amino acid|glutathione binding|neutrophil degranulation|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|negative regulation of JUN kinase activity|linoleic acid metabolic process|response to ethanol|negative regulation of fibroblast proliferation|hepoxilin biosynthetic process|negative regulation of nitric-oxide synthase biosynthetic process|nitric oxide binding|extracellular exosome|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|negative regulation of leukocyte proliferation|cellular response to lipopolysaccharide|cellular response to epidermal growth factor stimulus|cellular response to glucocorticoid stimulus|cellular response to cell-matrix adhesion|negative regulation of monocyte chemotactic protein-1 production|negative regulation of smooth muscle cell chemotaxis|TRAF2-GSTP1 complex|cellular oxidant detoxification|glutathione derivative biosynthetic process|negative regulation of vascular associated smooth muscle cell proliferation|ficolin-1-rich granule lumen|negative regulation of extrinsic apoptotic signaling pathway "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05215,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Prostate cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTT2B 277.7040264 259.8287279 295.579325 1.137592934 0.185984409 0.705789257 1 11.87672243 14.09286923 653689 glutathione S-transferase theta 2B "GO:0004364,GO:0005654,GO:0005737,GO:0005829,GO:0006749,GO:0070062,GO:1901687" glutathione transferase activity|nucleoplasm|cytoplasm|cytosol|glutathione metabolic process|extracellular exosome|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTZ1 250.8792005 244.6043884 257.1540127 1.051305802 0.072182379 0.893065778 1 4.162751801 4.564839458 2954 glutathione S-transferase zeta 1 "GO:0004364,GO:0004602,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0006559,GO:0006572,GO:0006749,GO:0010510,GO:0016034,GO:0042802,GO:0042803,GO:0098869,GO:1901687" glutathione transferase activity|glutathione peroxidase activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|L-phenylalanine catabolic process|tyrosine catabolic process|glutathione metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|maleylacetoacetate isomerase activity|identical protein binding|protein homodimerization activity|cellular oxidant detoxification|glutathione derivative biosynthetic process hsa00350 Tyrosine metabolism GSX2 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.061451212 0.124446297 170825 GS homeobox 2 "GO:0000785,GO:0000981,GO:0002087,GO:0005634,GO:0005737,GO:0006357,GO:0021527,GO:0021575,GO:0021798,GO:0021889,GO:0021978,GO:0030334,GO:0045747,GO:0048665,GO:0048714,GO:0048853,GO:0060163,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|regulation of respiratory gaseous exchange by nervous system process|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|spinal cord association neuron differentiation|hindbrain morphogenesis|forebrain dorsal/ventral pattern formation|olfactory bulb interneuron differentiation|telencephalon regionalization|regulation of cell migration|positive regulation of Notch signaling pathway|neuron fate specification|positive regulation of oligodendrocyte differentiation|forebrain morphogenesis|subpallium neuron fate commitment|sequence-specific double-stranded DNA binding" GTDC1 136.3740064 128.899408 143.8486048 1.115975683 0.158305591 0.805368168 1 0.348491981 0.405661181 79712 glycosyltransferase like domain containing 1 GTF2A1 1352.151702 1338.726922 1365.576481 1.020056039 0.028648412 0.934328981 1 10.19116126 10.84335396 2957 general transcription factor IIA subunit 1 "GO:0000979,GO:0001103,GO:0003677,GO:0005515,GO:0005654,GO:0005669,GO:0005672,GO:0005829,GO:0006366,GO:0006367,GO:0008134,GO:0016251,GO:0017025,GO:0042795,GO:0046982,GO:0097550" RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|DNA binding|protein binding|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIA complex|cytosol|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|snRNA transcription by RNA polymerase II|protein heterodimerization activity|transcription preinitiation complex "hsa03022,hsa05203" Basal transcription factors|Viral carcinogenesis GTF2A2 508.9642917 544.016399 473.9121844 0.871135843 -0.199030388 0.626926056 1 14.05740379 12.77341237 2958 general transcription factor IIA subunit 2 "GO:0001103,GO:0005515,GO:0005654,GO:0005669,GO:0005672,GO:0006366,GO:0006367,GO:0008134,GO:0016032,GO:0016251,GO:0017025,GO:0030054,GO:0042795,GO:0042803,GO:0045944,GO:0046982,GO:0051123" RNA polymerase II repressing transcription factor binding|protein binding|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIA complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|viral process|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|cell junction|snRNA transcription by RNA polymerase II|protein homodimerization activity|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|RNA polymerase II preinitiation complex assembly "hsa03022,hsa05203" Basal transcription factors|Viral carcinogenesis GTF2B 494.4607142 461.8049656 527.1164629 1.141426581 0.190838065 0.643911462 1 12.07475083 14.37613324 2959 general transcription factor IIB "GO:0000979,GO:0000993,GO:0001174,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005694,GO:0006352,GO:0006366,GO:0006367,GO:0006473,GO:0008134,GO:0008270,GO:0016251,GO:0016407,GO:0016573,GO:0016604,GO:0017025,GO:0019083,GO:0032993,GO:0042795,GO:0046966,GO:0051123,GO:0090575,GO:0097550,GO:1904798,GO:1990114,GO:1990841" "RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II complex binding|transcriptional start site selection at RNA polymerase II promoter|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|chromosome|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein acetylation|transcription factor binding|zinc ion binding|RNA polymerase II general transcription initiation factor activity|acetyltransferase activity|histone acetylation|nuclear body|TBP-class protein binding|viral transcription|protein-DNA complex|snRNA transcription by RNA polymerase II|thyroid hormone receptor binding|RNA polymerase II preinitiation complex assembly|RNA polymerase II transcription regulator complex|transcription preinitiation complex|positive regulation of core promoter binding|RNA polymerase II core complex assembly|promoter-specific chromatin binding" "hsa03022,hsa05017,hsa05203" Basal transcription factors|Spinocerebellar ataxia|Viral carcinogenesis other GTF2E1 472.3934637 502.4032043 442.383723 0.880535234 -0.183547361 0.660667007 1 8.481649976 7.790099668 2960 general transcription factor IIE subunit 1 "GO:0001113,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005673,GO:0005829,GO:0006366,GO:0006367,GO:0016032,GO:0016251,GO:0042795,GO:0046872,GO:0097550" transcription open complex formation at RNA polymerase II promoter|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIE complex|cytosol|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|viral process|RNA polymerase II general transcription initiation factor activity|snRNA transcription by RNA polymerase II|metal ion binding|transcription preinitiation complex "hsa03022,hsa05203" Basal transcription factors|Viral carcinogenesis GTF2E2 680.7011751 699.3046622 662.0976879 0.946794328 -0.078877031 0.838864189 1 12.03033768 11.8809015 2961 general transcription factor IIE subunit 2 "GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005669,GO:0005673,GO:0005829,GO:0006366,GO:0006367,GO:0016251,GO:0016607,GO:0042795" DNA binding|RNA binding|protein binding|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIE complex|cytosol|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|RNA polymerase II general transcription initiation factor activity|nuclear speck|snRNA transcription by RNA polymerase II "hsa03022,hsa05203" Basal transcription factors|Viral carcinogenesis GTF2F1 1957.586791 2011.642729 1903.530853 0.94625692 -0.07969615 0.8061484 1 41.84090661 41.29772086 2962 general transcription factor IIF subunit 1 "GO:0000398,GO:0001096,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005674,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008134,GO:0008543,GO:0009615,GO:0016070,GO:0016251,GO:0019211,GO:0019903,GO:0019904,GO:0030054,GO:0032091,GO:0032968,GO:0032991,GO:0042795,GO:0043231,GO:0045944,GO:0050434,GO:0050790,GO:1990841" "mRNA splicing, via spliceosome|TFIIF-class transcription factor complex binding|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIF complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription factor binding|fibroblast growth factor receptor signaling pathway|response to virus|RNA metabolic process|RNA polymerase II general transcription initiation factor activity|phosphatase activator activity|protein phosphatase binding|protein domain specific binding|cell junction|negative regulation of protein binding|positive regulation of transcription elongation from RNA polymerase II promoter|protein-containing complex|snRNA transcription by RNA polymerase II|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|positive regulation of viral transcription|regulation of catalytic activity|promoter-specific chromatin binding" hsa03022 Basal transcription factors GTF2F2 707.1966723 725.6935174 688.6998272 0.949022984 -0.075485068 0.844491992 1 7.542338716 7.466184061 2963 general transcription factor IIF subunit 2 "GO:0000398,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005674,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0015630,GO:0016070,GO:0016251,GO:0032508,GO:0042795,GO:0050434,GO:0097550" "mRNA splicing, via spliceosome|DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription factor TFIIF complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|microtubule cytoskeleton|RNA metabolic process|RNA polymerase II general transcription initiation factor activity|DNA duplex unwinding|snRNA transcription by RNA polymerase II|positive regulation of viral transcription|transcription preinitiation complex" hsa03022 Basal transcription factors GTF2H1 861.3472539 891.1313402 831.5631676 0.933154441 -0.099812222 0.785203266 1 13.74319691 13.37695377 2965 general transcription factor IIH subunit 1 "GO:0000079,GO:0000439,GO:0000717,GO:0003682,GO:0005515,GO:0005654,GO:0005675,GO:0006281,GO:0006283,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0009755,GO:0033683,GO:0045893,GO:0046966,GO:0070816,GO:0070911" "regulation of cyclin-dependent protein serine/threonine kinase activity|transcription factor TFIIH core complex|nucleotide-excision repair, DNA duplex unwinding|chromatin binding|protein binding|nucleoplasm|transcription factor TFIIH holo complex|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|hormone-mediated signaling pathway|nucleotide-excision repair, DNA incision|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|phosphorylation of RNA polymerase II C-terminal domain|global genome nucleotide-excision repair" "hsa03022,hsa03420,hsa05203" Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H2 226.4257394 256.78386 196.0676189 0.763551178 -0.389203235 0.454044189 1 4.658021716 3.709843509 2966 general transcription factor IIH subunit 2 "GO:0000438,GO:0000439,GO:0000717,GO:0002031,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006357,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008270,GO:0009411,GO:0016032,GO:0016251,GO:0016607,GO:0033683,GO:0047485,GO:0070911,GO:1905776" "core TFIIH complex portion of holo TFIIH complex|transcription factor TFIIH core complex|nucleotide-excision repair, DNA duplex unwinding|G protein-coupled receptor internalization|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|zinc ion binding|response to UV|viral process|RNA polymerase II general transcription initiation factor activity|nuclear speck|nucleotide-excision repair, DNA incision|protein N-terminus binding|global genome nucleotide-excision repair|positive regulation of DNA helicase activity" "hsa03022,hsa03420,hsa05203" Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H2C 280.090237 288.247495 271.932979 0.943401014 -0.084056944 0.868715741 1 7.823536306 7.698664085 728340 GTF2H2 family member C "GO:0000439,GO:0005515,GO:0005675,GO:0006289,GO:0006351,GO:0006357,GO:0008270,GO:0016607" "transcription factor TFIIH core complex|protein binding|transcription factor TFIIH holo complex|nucleotide-excision repair|transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|nuclear speck" "hsa03022,hsa03420,hsa05203" Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H3 890.3410469 852.5630134 928.1190804 1.088622267 0.122503451 0.735555892 1 19.50284958 22.14579188 2967 general transcription factor IIH subunit 3 "GO:0000438,GO:0000439,GO:0000717,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0016251,GO:0033683,GO:0046872,GO:0047485,GO:0070816,GO:0070911,GO:0097550" "core TFIIH complex portion of holo TFIIH complex|transcription factor TFIIH core complex|nucleotide-excision repair, DNA duplex unwinding|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|RNA polymerase II general transcription initiation factor activity|nucleotide-excision repair, DNA incision|metal ion binding|protein N-terminus binding|phosphorylation of RNA polymerase II C-terminal domain|global genome nucleotide-excision repair|transcription preinitiation complex" "hsa03022,hsa03420,hsa05203" Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H4 560.1980414 544.016399 576.3796837 1.059489539 0.083369343 0.837668991 1 16.09375668 17.78566196 2968 general transcription factor IIH subunit 4 "GO:0000438,GO:0000439,GO:0000717,GO:0001671,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0016251,GO:0016607,GO:0032781,GO:0033683,GO:0070816,GO:0070911" "core TFIIH complex portion of holo TFIIH complex|transcription factor TFIIH core complex|nucleotide-excision repair, DNA duplex unwinding|ATPase activator activity|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|RNA polymerase II general transcription initiation factor activity|nuclear speck|positive regulation of ATPase activity|nucleotide-excision repair, DNA incision|phosphorylation of RNA polymerase II C-terminal domain|global genome nucleotide-excision repair" "hsa03022,hsa03420,hsa05203" Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H5 349.5162436 353.204677 345.8278102 0.97911447 -0.030450557 0.952971811 1 2.379748684 2.43041532 404672 general transcription factor IIH subunit 5 "GO:0000439,GO:0000462,GO:0000717,GO:0005515,GO:0005654,GO:0005669,GO:0005675,GO:0005730,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0033683,GO:0070816,GO:0070911,GO:0071480" "transcription factor TFIIH core complex|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nucleotide-excision repair, DNA duplex unwinding|protein binding|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|nucleolus|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|nucleotide-excision repair, DNA incision|phosphorylation of RNA polymerase II C-terminal domain|global genome nucleotide-excision repair|cellular response to gamma radiation" "hsa03022,hsa03420" Basal transcription factors|Nucleotide excision repair GTF2I 1940.471595 1919.281736 1961.661453 1.02208103 0.031509577 0.923870322 1 20.99003436 22.37764639 2969 general transcription factor IIi "GO:0000981,GO:0001102,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016020,GO:0016525,GO:0045944,GO:0100026" "DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|membrane|negative regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of DNA repair by transcription from RNA polymerase II promoter" "hsa03022,hsa04022" Basal transcription factors|cGMP-PKG signaling pathway other GTF2IRD1 752.281303 709.4542219 795.1083842 1.120732472 0.164441937 0.660309007 1 6.928529413 8.099513809 9569 GTF2I repeat domain containing 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006366,GO:0007275,GO:0014886" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|transcription by RNA polymerase II|multicellular organism development|transition between slow and fast fiber" "hsa03022,hsa04022" Basal transcription factors|cGMP-PKG signaling pathway GTF2IRD2 22.9579971 20.29911937 25.61687483 1.261969762 0.335677342 0.784619382 1 0.181639361 0.239097395 84163 GTF2I repeat domain containing 2 "GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II" GTF2IRD2B 75.44151354 72.06187375 78.82115332 1.093798277 0.129346694 0.878647292 1 0.796351666 0.908569299 389524 GTF2I repeat domain containing 2B "GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II" GTF3A 1083.906165 1152.98998 1014.822349 0.880165801 -0.184152779 0.597319003 1 40.46768883 37.15256661 2971 general transcription factor IIIA "GO:0003677,GO:0005634,GO:0005654,GO:0006383,GO:0008097,GO:0009303,GO:0042273,GO:0046872" DNA binding|nucleus|nucleoplasm|transcription by RNA polymerase III|5S rRNA binding|rRNA transcription|ribosomal large subunit biogenesis|metal ion binding zf-C2H2 GTF3C1 2833.48216 2988.030371 2678.933949 0.896555127 -0.157535801 0.621073881 1 21.34459762 19.96093591 2975 general transcription factor IIIC subunit 1 "GO:0000127,GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0006383,GO:0006384,GO:0009303,GO:0009304,GO:0016020,GO:0042791,GO:0042797,GO:1990904" transcription factor TFIIIC complex|DNA binding|protein binding|nucleoplasm|nucleolus|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|rRNA transcription|tRNA transcription|membrane|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III|ribonucleoprotein complex other GTF3C2 1340.146174 1562.017235 1118.275113 0.715917269 -0.482135215 0.152181399 1 19.65482298 14.67735859 2976 general transcription factor IIIC subunit 2 "GO:0000127,GO:0003677,GO:0005515,GO:0005654,GO:0006383,GO:0042791,GO:0042797" transcription factor TFIIIC complex|DNA binding|protein binding|nucleoplasm|transcription by RNA polymerase III|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III other GTF3C3 971.8953068 837.3386739 1106.45194 1.321391182 0.402057622 0.25641101 1 8.785632873 12.10933755 9330 general transcription factor IIIC subunit 3 "GO:0000127,GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0006383,GO:0031965,GO:0042791,GO:0042797" transcription factor TFIIIC complex|DNA binding|protein binding|nucleoplasm|nucleolus|transcription by RNA polymerase III|nuclear membrane|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III GTF3C4 1432.843423 1466.611374 1399.075471 0.953951058 -0.068012844 0.840134646 1 10.84677164 10.79300854 9329 general transcription factor IIIC subunit 4 "GO:0000127,GO:0003677,GO:0004402,GO:0005515,GO:0005654,GO:0005739,GO:0006383,GO:0006384,GO:0008047,GO:0016573,GO:0042791,GO:0042797,GO:0050790" transcription factor TFIIIC complex|DNA binding|histone acetyltransferase activity|protein binding|nucleoplasm|mitochondrion|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|enzyme activator activity|histone acetylation|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III|regulation of catalytic activity GTF3C5 1594.299856 1558.972367 1629.627345 1.045321507 0.063946737 0.847559797 1 33.78538754 36.83788779 9328 general transcription factor IIIC subunit 5 "GO:0000127,GO:0003677,GO:0005515,GO:0005654,GO:0006383,GO:0006384,GO:0035914,GO:0042791,GO:0042797" transcription factor TFIIIC complex|DNA binding|protein binding|nucleoplasm|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|skeletal muscle cell differentiation|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III other GTF3C6 394.2067194 411.0571672 377.3562715 0.918014091 -0.123411797 0.781274054 1 26.4195373 25.29825025 112495 general transcription factor IIIC subunit 6 "GO:0000127,GO:0003677,GO:0005515,GO:0005654,GO:0006383,GO:0016604,GO:0042791,GO:0042797" transcription factor TFIIIC complex|DNA binding|protein binding|nucleoplasm|transcription by RNA polymerase III|nuclear body|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III GTPBP1 900.0034176 805.8750389 994.1317963 1.233605396 0.302880981 0.399408525 1 9.603465356 12.35720251 9567 GTP binding protein 1 "GO:0000177,GO:0003723,GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0006414,GO:0006955,GO:0007165,GO:0016020,GO:0046039,GO:0061014" cytoplasmic exosome (RNase complex)|RNA binding|translation elongation factor activity|GTPase activity|protein binding|GTP binding|cytosol|translational elongation|immune response|signal transduction|membrane|GTP metabolic process|positive regulation of mRNA catabolic process GTPBP10 416.8799251 445.5656701 388.1941801 0.87123898 -0.198859591 0.645556887 1 3.013263364 2.738358593 85865 GTP binding protein 10 "GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005694,GO:0005730,GO:0005739,GO:0042254" RNA binding|GTPase activity|protein binding|GTP binding|chromosome|nucleolus|mitochondrion|ribosome biogenesis GTPBP2 1543.224213 1266.665049 1819.783377 1.436672923 0.522731651 0.113978892 1 17.71668494 26.54949706 54676 GTP binding protein 2 "GO:0002576,GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005576,GO:0006414,GO:0008150,GO:0031093,GO:0042802" platelet degranulation|translation elongation factor activity|GTPase activity|protein binding|GTP binding|extracellular region|translational elongation|biological_process|platelet alpha granule lumen|identical protein binding GTPBP3 492.8492056 452.6703619 533.0280494 1.177519215 0.235750603 0.567261434 1 8.469212008 10.40224162 84705 "GTP binding protein 3, mitochondrial" "GO:0002098,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0030488" tRNA wobble uridine modification|GTPase activity|protein binding|GTP binding|cytoplasm|mitochondrion|tRNA methylation GTPBP4 1804.962603 1984.238918 1625.686287 0.819299668 -0.287536864 0.376370994 1 38.6369478 33.01881781 23560 GTP binding protein 4 "GO:0000079,GO:0000463,GO:0001649,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0008156,GO:0008285,GO:0016020,GO:0022408,GO:0030336,GO:0031397,GO:0031965,GO:0033342,GO:0048471,GO:0050821" "regulation of cyclin-dependent protein serine/threonine kinase activity|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|osteoblast differentiation|RNA binding|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|negative regulation of DNA replication|negative regulation of cell population proliferation|membrane|negative regulation of cell-cell adhesion|negative regulation of cell migration|negative regulation of protein ubiquitination|nuclear membrane|negative regulation of collagen binding|perinuclear region of cytoplasm|protein stabilization" hsa03008 Ribosome biogenesis in eukaryotes GTPBP6-2 67.28945264 87.28621328 47.29269199 0.541811704 -0.884136535 0.253501012 1 1.216159223 0.687313303 8225 GTP binding protein 6 (putative) GTPBP8 171.8974653 199.9463258 143.8486048 0.7194361 -0.475061542 0.403254664 1 5.27151277 3.955882822 29083 GTP binding protein 8 (putative) "GO:0005515,GO:0005525,GO:0005739,GO:0046872" protein binding|GTP binding|mitochondrion|metal ion binding GTSE1 2596.981336 2345.563243 2848.399428 1.214377586 0.280217068 0.37953578 1 20.53846881 26.01583295 51512 G2 and S-phase expressed 1 "GO:0003674,GO:0005515,GO:0005654,GO:0005829,GO:0005881,GO:0006977,GO:0007017,GO:0008017,GO:0015630,GO:0016020,GO:0030335,GO:0046827,GO:0050821,GO:1900182,GO:1902749" "molecular_function|protein binding|nucleoplasm|cytosol|cytoplasmic microtubule|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|microtubule-based process|microtubule binding|microtubule cytoskeleton|membrane|positive regulation of cell migration|positive regulation of protein export from nucleus|protein stabilization|positive regulation of protein localization to nucleus|regulation of cell cycle G2/M phase transition" hsa04115 p53 signaling pathway GUCA1B 9.000991732 9.134603715 8.867379749 0.970745971 -0.042834281 1 1 0.203804164 0.206364305 2979 guanylate cyclase activator 1B "GO:0001917,GO:0005509,GO:0005515,GO:0005886,GO:0007168,GO:0007267,GO:0007589,GO:0007601,GO:0008048,GO:0022400,GO:0031284,GO:0097381,GO:0120199" photoreceptor inner segment|calcium ion binding|protein binding|plasma membrane|receptor guanylyl cyclase signaling pathway|cell-cell signaling|body fluid secretion|visual perception|calcium sensitive guanylate cyclase activator activity|regulation of rhodopsin mediated signaling pathway|positive regulation of guanylate cyclase activity|photoreceptor disc membrane|cone photoreceptor outer segment hsa04744 Phototransduction GUCD1 2477.248944 2074.569999 2879.92789 1.388204732 0.473220352 0.138489996 1 28.25972346 40.92016326 83606 guanylyl cyclase domain containing 1 GO:0005515 protein binding GUCY1A1 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.015878482 0.005359315 2982 guanylate cyclase 1 soluble subunit alpha 1 "GO:0004383,GO:0005515,GO:0005525,GO:0006182,GO:0007263,GO:0008015,GO:0008074,GO:0008217,GO:0010750,GO:0020037,GO:0038023,GO:0060087,GO:0098925,GO:0098978,GO:0098982" "guanylate cyclase activity|protein binding|GTP binding|cGMP biosynthetic process|nitric oxide mediated signal transduction|blood circulation|guanylate cyclase complex, soluble|regulation of blood pressure|positive regulation of nitric oxide mediated signal transduction|heme binding|signaling receptor activity|relaxation of vascular associated smooth muscle|retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission|glutamatergic synapse|GABA-ergic synapse" "hsa00230,hsa04022,hsa04270,hsa04540,hsa04611,hsa04713,hsa04730,hsa04921,hsa04924,hsa04970" Purine metabolism|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Long-term depression|Oxytocin signaling pathway|Renin secretion|Salivary secretion GUCY1A2 175.9721349 209.0809295 142.8633404 0.683292067 -0.549425718 0.329240258 1 0.651924613 0.464643307 2977 guanylate cyclase 1 soluble subunit alpha 2 "GO:0004383,GO:0005515,GO:0005525,GO:0005737,GO:0006182,GO:0007165,GO:0010750,GO:0020037,GO:0035556,GO:0044877" guanylate cyclase activity|protein binding|GTP binding|cytoplasm|cGMP biosynthetic process|signal transduction|positive regulation of nitric oxide mediated signal transduction|heme binding|intracellular signal transduction|protein-containing complex binding "hsa00230,hsa04022,hsa04270,hsa04540,hsa04611,hsa04713,hsa04730,hsa04921,hsa04924,hsa04970" Purine metabolism|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Long-term depression|Oxytocin signaling pathway|Renin secretion|Salivary secretion GUCY2D 5.926432275 1.014955968 10.83790858 10.67820568 3.416597337 0.095128455 1 0.007581702 0.084446357 3000 "guanylate cyclase 2D, retinal" "GO:0001653,GO:0001750,GO:0004383,GO:0004672,GO:0005515,GO:0005524,GO:0005525,GO:0005640,GO:0005789,GO:0005886,GO:0005887,GO:0006182,GO:0006468,GO:0007165,GO:0007168,GO:0007601,GO:0022400,GO:0035556,GO:0038023,GO:0042622,GO:0042803,GO:0097381" peptide receptor activity|photoreceptor outer segment|guanylate cyclase activity|protein kinase activity|protein binding|ATP binding|GTP binding|nuclear outer membrane|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cGMP biosynthetic process|protein phosphorylation|signal transduction|receptor guanylyl cyclase signaling pathway|visual perception|regulation of rhodopsin mediated signaling pathway|intracellular signal transduction|signaling receptor activity|photoreceptor outer segment membrane|protein homodimerization activity|photoreceptor disc membrane "hsa00230,hsa04740,hsa04744" Purine metabolism|Olfactory transduction|Phototransduction GUF1 624.3035709 683.0653667 565.5417751 0.827946786 -0.272390049 0.482959247 1 8.211452911 7.091504146 60558 GTP binding elongation factor GUF1 "GO:0003924,GO:0005525,GO:0005739,GO:0005743,GO:0005759,GO:0006412,GO:0043022,GO:0045727" GTPase activity|GTP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|translation|ribosome binding|positive regulation of translation GUK1 1993.161468 2187.230112 1799.092825 0.822543917 -0.281835385 0.382062905 1 76.34423782 65.5015065 2987 guanylate kinase 1 "GO:0001917,GO:0004385,GO:0005515,GO:0005524,GO:0005829,GO:0006163,GO:0006185,GO:0006805,GO:0015949,GO:0016310,GO:0046037,GO:0046710" photoreceptor inner segment|guanylate kinase activity|protein binding|ATP binding|cytosol|purine nucleotide metabolic process|dGDP biosynthetic process|xenobiotic metabolic process|nucleobase-containing small molecule interconversion|phosphorylation|GMP metabolic process|GDP metabolic process hsa00230 Purine metabolism GULP1 585.2601793 573.4501221 597.0702364 1.041189483 0.058232645 0.886396696 1 4.526687294 4.916162127 51454 GULP PTB domain containing engulfment adaptor 1 "GO:0005737,GO:0006869,GO:0006911,GO:0006915" "cytoplasm|lipid transport|phagocytosis, engulfment|apoptotic process" GUSB 1444.105178 1394.549501 1493.660855 1.071070518 0.099053468 0.767640517 1 32.20657206 35.98143647 2990 glucuronidase beta "GO:0004566,GO:0005102,GO:0005576,GO:0005615,GO:0005975,GO:0006027,GO:0016020,GO:0019391,GO:0019904,GO:0030214,GO:0030246,GO:0035578,GO:0043202,GO:0043231,GO:0043312,GO:0070062,GO:1904813" beta-glucuronidase activity|signaling receptor binding|extracellular region|extracellular space|carbohydrate metabolic process|glycosaminoglycan catabolic process|membrane|glucuronoside catabolic process|protein domain specific binding|hyaluronan catabolic process|carbohydrate binding|azurophil granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|ficolin-1-rich granule lumen "hsa00040,hsa00053,hsa00531,hsa00860,hsa00983,hsa04142" Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Glycosaminoglycan degradation|Porphyrin and chlorophyll metabolism|Drug metabolism - other enzymes|Lysosome GVQW3 315.1804468 363.3542367 267.0066569 0.73483843 -0.444501017 0.34041978 1 1.022935534 0.784072199 100506127 GVQW motif containing 3 GXYLT1 494.4795194 597.8090654 391.1499734 0.654305858 -0.611962908 0.135599267 1 3.943847886 2.691639507 283464 glucoside xylosyltransferase 1 "GO:0016021,GO:0016266,GO:0035252,GO:0140563" "integral component of membrane|O-glycan processing|UDP-xylosyltransferase activity|UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity" hsa00514 Other types of O-glycan biosynthesis GXYLT2 122.4412494 186.7518982 58.13060058 0.311271806 -1.683753188 0.009275579 0.405005328 2.641252394 0.857562178 727936 glucoside xylosyltransferase 2 "GO:0016021,GO:0016266,GO:0035252,GO:0140563" "integral component of membrane|O-glycan processing|UDP-xylosyltransferase activity|UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity" hsa00514 Other types of O-glycan biosynthesis GYG1 344.907126 307.5316584 382.2825936 1.243067447 0.313904577 0.490025552 1 5.438335751 7.051420921 2992 glycogenin 1 "GO:0005515,GO:0005576,GO:0005829,GO:0005978,GO:0008466,GO:0016020,GO:0016757,GO:0030145,GO:0034774,GO:0042803,GO:0043202,GO:0043312,GO:0102751,GO:1904813" "protein binding|extracellular region|cytosol|glycogen biosynthetic process|glycogenin glucosyltransferase activity|membrane|transferase activity, transferring glycosyl groups|manganese ion binding|secretory granule lumen|protein homodimerization activity|lysosomal lumen|neutrophil degranulation|UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity|ficolin-1-rich granule lumen" hsa00500 Starch and sucrose metabolism GYPE 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.018587575 0.028231602 2996 glycophorin E (MNS blood group) "GO:0005886,GO:0005887" plasma membrane|integral component of plasma membrane GYS1 1826.886593 2236.962954 1416.810231 0.633363297 -0.658894829 0.042874571 0.945969192 31.7439849 20.97153724 2997 glycogen synthase 1 "GO:0004373,GO:0005515,GO:0005536,GO:0005737,GO:0005829,GO:0005978,GO:0007507,GO:0016020,GO:0016234,GO:0019901,GO:0061547" "glycogen (starch) synthase activity|protein binding|glucose binding|cytoplasm|cytosol|glycogen biosynthetic process|heart development|membrane|inclusion body|protein kinase binding|glycogen synthase activity, transferring glucose-1-phosphate" "hsa00500,hsa04151,hsa04152,hsa04910,hsa04922,hsa04931" Starch and sucrose metabolism|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance GZF1 773.4887363 778.4712277 768.5062449 0.987199292 -0.018586735 0.963718737 1 7.011705745 7.220120521 64412 GDNF inducible zinc finger protein 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001658,GO:0005654,GO:0005730,GO:0005737,GO:0006355,GO:0043565,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|branching involved in ureteric bud morphogenesis|nucleoplasm|nucleolus|cytoplasm|regulation of transcription, DNA-templated|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding" H1-0 13101.36583 12414.94141 13787.79025 1.110580372 0.151313804 0.661187341 1 285.2871982 330.4823021 3005 H1.0 linker histone "GO:0000122,GO:0000785,GO:0000786,GO:0000791,GO:0003680,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0006309,GO:0006334,GO:0006342,GO:0015629,GO:0016584,GO:0016604,GO:0017053,GO:0030261,GO:0031490,GO:0031492,GO:0031936,GO:0045910,GO:2000679" negative regulation of transcription by RNA polymerase II|chromatin|nucleosome|euchromatin|minor groove of adenine-thymine-rich DNA binding|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|Golgi apparatus|apoptotic DNA fragmentation|nucleosome assembly|chromatin silencing|actin cytoskeleton|nucleosome positioning|nuclear body|transcription repressor complex|chromosome condensation|chromatin DNA binding|nucleosomal DNA binding|negative regulation of chromatin silencing|negative regulation of DNA recombination|positive regulation of transcription regulatory region DNA binding H1-10 1954.036175 1432.102871 2475.969479 1.728904765 0.789858402 0.014845048 0.536559397 47.84364003 86.28021431 8971 H1.10 linker histone "GO:0000786,GO:0003690,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006334,GO:0016584,GO:0030261,GO:0031492,GO:0031936,GO:0045296,GO:0045910" nucleosome|double-stranded DNA binding|RNA binding|nucleus|nucleoplasm|nucleolus|nucleosome assembly|nucleosome positioning|chromosome condensation|nucleosomal DNA binding|negative regulation of chromatin silencing|cadherin binding|negative regulation of DNA recombination H1-2 74.09450729 114.6900244 33.49899016 0.292082858 -1.775550402 0.020323381 0.616714654 7.946162975 2.420914591 3006 "H1.2 linker histone, cluster member" "GO:0000786,GO:0000791,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0006334,GO:0016584,GO:0030261,GO:0031490,GO:0031492,GO:0031936,GO:0045910" nucleosome|euchromatin|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleosome assembly|nucleosome positioning|chromosome condensation|chromatin DNA binding|nucleosomal DNA binding|negative regulation of chromatin silencing|negative regulation of DNA recombination H1-4 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.065316314 0.198410408 3008 "H1.4 linker histone, cluster member" "GO:0000786,GO:0000792,GO:0003690,GO:0003723,GO:0005509,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0006334,GO:0016208,GO:0016584,GO:0030261,GO:0031490,GO:0031492,GO:0031936,GO:0032564,GO:0043531,GO:0045910" nucleosome|heterochromatin|double-stranded DNA binding|RNA binding|calcium ion binding|protein binding|ATP binding|GTP binding|nucleus|nucleosome assembly|AMP binding|nucleosome positioning|chromosome condensation|chromatin DNA binding|nucleosomal DNA binding|negative regulation of chromatin silencing|dATP binding|ADP binding|negative regulation of DNA recombination H2AC11 9.553007044 13.19442759 5.911586499 0.448036602 -1.158311499 0.436032871 1 1.355479128 0.633464467 8969 H2A clustered histone 11 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0006342,GO:0008150,GO:0019899,GO:0046982,GO:0070062" nucleosome|DNA binding|protein binding|nucleus|chromatin silencing|biological_process|enzyme binding|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC13 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.311539026 0.105150836 8329 H2A clustered histone 13 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0006342,GO:0008150,GO:0019899,GO:0046982,GO:0070062" nucleosome|DNA binding|protein binding|nucleus|chromatin silencing|biological_process|enzyme binding|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC15 3.044867905 6.08973581 0 0 #NAME? 0.124110187 1 0.621821846 0 8330 H2A clustered histone 15 "GO:0000786,GO:0003674,GO:0003677,GO:0005515,GO:0005634,GO:0006342,GO:0008150,GO:0019899,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|protein binding|nucleus|chromatin silencing|biological_process|enzyme binding|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC17 4.059823873 8.119647747 0 0 #NAME? 0.065967888 1 0.844417893 0 8336 H2A clustered histone 17 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0006342,GO:0008150,GO:0019899,GO:0046982,GO:0070062" nucleosome|DNA binding|protein binding|nucleus|chromatin silencing|biological_process|enzyme binding|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC20 10.0159477 11.16451565 8.867379749 0.794246703 -0.332340898 0.878848877 1 1.144622129 0.948273225 8338 H2A clustered histone 20 "GO:0000786,GO:0003674,GO:0003677,GO:0005634,GO:0006342,GO:0008150,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|nucleus|chromatin silencing|biological_process|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC6 74.1538904 118.7498483 29.5579325 0.248909223 -2.006308405 0.009393635 0.40793681 11.58817128 3.008651081 8334 H2A clustered histone 6 "GO:0000786,GO:0003674,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006342,GO:0008285,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|protein binding|nucleus|nucleoplasm|chromatin silencing|negative regulation of cell population proliferation|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC8 4.52276453 6.08973581 2.95579325 0.485372985 -1.042834281 0.660953233 1 0.547821733 0.277351672 3012 H2A clustered histone 8 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0006342,GO:0008285,GO:0046982,GO:0070062" nucleosome|DNA binding|protein binding|nucleus|chromatin silencing|negative regulation of cell population proliferation|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AJ 863.3420311 960.1483461 766.5357161 0.798351337 -0.32490431 0.369664539 1 78.43246214 65.31393285 55766 H2A.J histone "GO:0000786,GO:0003674,GO:0003677,GO:0005634,GO:0006342,GO:0008150,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|nucleus|chromatin silencing|biological_process|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AW 60.28868129 80.1815215 40.39584108 0.503804871 -0.989063025 0.217669543 1 7.962570982 4.184384729 92815 H2A.W histone "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0006337,GO:0006342,GO:0046982,GO:0070062,GO:0070914" nucleosome|DNA binding|protein binding|nucleus|nucleosome disassembly|chromatin silencing|protein heterodimerization activity|extracellular exosome|UV-damage excision repair "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AX 1738.496349 2054.27088 1422.721817 0.692567777 -0.529972829 0.104513199 1 65.35274688 47.21087588 3014 H2A.X variant histone "GO:0000077,GO:0000724,GO:0000781,GO:0000786,GO:0000794,GO:0001673,GO:0001741,GO:0003677,GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005813,GO:0006302,GO:0006303,GO:0006334,GO:0006342,GO:0006974,GO:0007283,GO:0010212,GO:0016032,GO:0016607,GO:0019899,GO:0021987,GO:0035861,GO:0042393,GO:0045739,GO:0046982,GO:0051321,GO:0070062,GO:0071480,GO:0090398,GO:0090734" "DNA damage checkpoint|double-strand break repair via homologous recombination|chromosome, telomeric region|nucleosome|condensed nuclear chromosome|male germ cell nucleus|XY body|DNA binding|damaged DNA binding|protein binding|nucleus|nucleoplasm|replication fork|centrosome|double-strand break repair|double-strand break repair via nonhomologous end joining|nucleosome assembly|chromatin silencing|cellular response to DNA damage stimulus|spermatogenesis|response to ionizing radiation|viral process|nuclear speck|enzyme binding|cerebral cortex development|site of double-strand break|histone binding|positive regulation of DNA repair|protein heterodimerization activity|meiotic cell cycle|extracellular exosome|cellular response to gamma radiation|cellular senescence|site of DNA damage" "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AZ1 5800.215516 5588.347562 6012.08347 1.075824902 0.105443289 0.744878614 1 326.8245837 366.7517875 3015 H2A.Z variant histone 1 "GO:0000786,GO:0000791,GO:0000792,GO:0000978,GO:0000979,GO:0001740,GO:0003677,GO:0005515,GO:0005634,GO:0006342,GO:0031490,GO:0031492,GO:0045944,GO:0046982,GO:0070062,GO:0071392" nucleosome|euchromatin|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|Barr body|DNA binding|protein binding|nucleus|chromatin silencing|chromatin DNA binding|nucleosomal DNA binding|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|extracellular exosome|cellular response to estradiol stimulus "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AZ2 4399.453807 4294.278702 4504.628912 1.048983828 0.068992437 0.829563679 1 34.516754 37.76718973 94239 H2A.Z variant histone 2 "GO:0000786,GO:0003674,GO:0003677,GO:0005634,GO:0006342,GO:0008150,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|nucleus|chromatin silencing|biological_process|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2BC11 10.59765456 17.25425146 3.941057666 0.228410817 -2.130297123 0.136104822 1 1.820556182 0.433747198 8970 H2B clustered histone 11 "GO:0000786,GO:0001530,GO:0002227,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006334,GO:0010804,GO:0016567,GO:0019731,GO:0031640,GO:0046982,GO:0050829,GO:0050830,GO:0061844" nucleosome|lipopolysaccharide binding|innate immune response in mucosa|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|plasma membrane|nucleosome assembly|negative regulation of tumor necrosis factor-mediated signaling pathway|protein ubiquitination|antibacterial humoral response|killing of cells of other organism|protein heterodimerization activity|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC12 176.9222646 274.0381115 79.80641774 0.291223791 -1.779799875 0.001991122 0.141296673 15.64719684 4.753125998 85236 H2B clustered histone 12 "GO:0000786,GO:0002227,GO:0003674,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0019731,GO:0031640,GO:0046982,GO:0050829,GO:0050830,GO:0061844" nucleosome|innate immune response in mucosa|molecular_function|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|antibacterial humoral response|killing of cells of other organism|protein heterodimerization activity|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC15 4.537610306 7.104691779 1.970528833 0.277355992 -1.850189203 0.383956367 1 0.663888514 0.19206518 8341 H2B clustered histone 15 "GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0046982,GO:0070062" nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|protein heterodimerization activity|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC17 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.330218025 0.111455383 8348 H2B clustered histone 17 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0046982" nucleosome|DNA binding|protein binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|protein heterodimerization activity "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC18 3.537500113 6.08973581 0.985264417 0.161790995 -2.627796782 0.2971307 1 0.289871838 0.048918857 440689 H2B clustered histone 18 "GO:0000786,GO:0003674,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein heterodimerization activity|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC21 71.84190872 95.40586103 48.27795641 0.506027155 -0.982713289 0.194816495 1 2.172648511 1.146777663 8349 H2B clustered histone 21 "GO:0000786,GO:0002227,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0019731,GO:0046982,GO:0050830,GO:0061844,GO:0070062" nucleosome|innate immune response in mucosa|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|nucleosome assembly|antibacterial humoral response|protein heterodimerization activity|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC4 16.64285305 26.38885518 6.896850916 0.261354684 -1.935919077 0.109957889 1 0.55090784 0.15018452 8347 H2B clustered histone 4 "GO:0000786,GO:0002227,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0019731,GO:0042802,GO:0046982,GO:0050830,GO:0061844,GO:0070062" nucleosome|innate immune response in mucosa|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|antibacterial humoral response|identical protein binding|protein heterodimerization activity|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC5 86.43728245 150.2134833 22.66108158 0.150859171 -2.728725691 0.000350597 0.04318862 5.763471976 0.906925959 3017 H2B clustered histone 5 "GO:0000786,GO:0003674,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|protein binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|protein heterodimerization activity|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC8 9.075220612 14.20938356 3.941057666 0.277355992 -1.850189203 0.218517863 1 1.471687422 0.42576412 8339 H2B clustered histone 8 "GO:0000786,GO:0002227,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0019731,GO:0042802,GO:0046982,GO:0050830,GO:0061844,GO:0070062" nucleosome|innate immune response in mucosa|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|antibacterial humoral response|identical protein binding|protein heterodimerization activity|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC9 25.03244636 27.40381115 22.66108158 0.826931753 -0.274159827 0.824255662 1 3.00412632 2.591217024 8345 H2B clustered histone 9 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0019899,GO:0032991,GO:0044389,GO:0046982,GO:0070062,GO:0097677" nucleosome|DNA binding|protein binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|enzyme binding|protein-containing complex|ubiquitin-like protein ligase binding|protein heterodimerization activity|extracellular exosome|STAT family protein binding "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BU1 6.985925571 6.08973581 7.882115332 1.294327961 0.372203218 0.905012836 1 0.676367622 0.913151995 128312 H2B.U histone 1 "GO:0000786,GO:0003674,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0046982" nucleosome|molecular_function|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein heterodimerization activity "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H3-2 49.76525561 68.00204988 31.52846133 0.463639867 -1.108923472 0.193642356 1 1.288463872 0.623116064 440686 H3.2 histone (putative) H3-3A 3348.918464 3065.167024 3632.669904 1.185145826 0.245064586 0.441142336 1 104.048188 128.6240684 3020 H3.3 histone A "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0000978,GO:0000979,GO:0001649,GO:0001740,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006334,GO:0006336,GO:0006997,GO:0007286,GO:0007338,GO:0007566,GO:0007596,GO:0008283,GO:0008584,GO:0030307,GO:0031492,GO:0031508,GO:0031509,GO:0032200,GO:0032991,GO:0035264,GO:0042692,GO:0044267,GO:0045652,GO:0045814,GO:0046982,GO:0048477,GO:0060964,GO:0070062,GO:0090230,GO:1902340" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|osteoblast differentiation|Barr body|protein binding|extracellular region|nucleus|nucleoplasm|nucleosome assembly|DNA replication-independent nucleosome assembly|nucleus organization|spermatid development|single fertilization|embryo implantation|blood coagulation|cell population proliferation|male gonad development|positive regulation of cell growth|nucleosomal DNA binding|pericentric heterochromatin assembly|subtelomeric heterochromatin assembly|telomere organization|protein-containing complex|multicellular organism growth|muscle cell differentiation|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|oogenesis|regulation of gene silencing by miRNA|extracellular exosome|regulation of centromere complex assembly|negative regulation of chromosome condensation" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3-3B 16302.81778 18668.08513 13937.55044 0.746597755 -0.421596925 0.234166223 1 349.5277836 272.1976129 3021 H3.3 histone B "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0000978,GO:0000979,GO:0001649,GO:0001740,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006334,GO:0006336,GO:0006997,GO:0007286,GO:0007338,GO:0007566,GO:0007596,GO:0008283,GO:0008584,GO:0030307,GO:0031492,GO:0031508,GO:0031509,GO:0032200,GO:0032991,GO:0035264,GO:0042692,GO:0044267,GO:0045652,GO:0045814,GO:0046982,GO:0048477,GO:0060964,GO:0070062,GO:0090230,GO:1902340" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|osteoblast differentiation|Barr body|protein binding|extracellular region|nucleus|nucleoplasm|nucleosome assembly|DNA replication-independent nucleosome assembly|nucleus organization|spermatid development|single fertilization|embryo implantation|blood coagulation|cell population proliferation|male gonad development|positive regulation of cell growth|nucleosomal DNA binding|pericentric heterochromatin assembly|subtelomeric heterochromatin assembly|telomere organization|protein-containing complex|multicellular organism growth|muscle cell differentiation|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|oogenesis|regulation of gene silencing by miRNA|extracellular exosome|regulation of centromere complex assembly|negative regulation of chromosome condensation" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3-5 81.78362754 101.4955968 62.07165824 0.611569961 -0.709410548 0.329189975 1 4.614357204 2.943562669 440093 H3.5 histone "GO:0000786,GO:0000791,GO:0005515,GO:0005634,GO:0030307,GO:0031492,GO:0046982" nucleosome|euchromatin|protein binding|nucleus|positive regulation of cell growth|nucleosomal DNA binding|protein heterodimerization activity "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C1 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.404755427 0 8350 H3 clustered histone 1 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C10 9.582698596 15.22433953 3.941057666 0.258865592 -1.949724877 0.186253211 1 1.586541335 0.428392294 8357 H3 clustered histone 10 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C2 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.301784379 0 8358 H3 clustered histone 2 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C4 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.164404923 0.221960186 8351 H3 clustered histone 4 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C6 16.59831572 23.34398727 9.852644165 0.422063465 -1.244468142 0.298460188 1 0.437885408 0.192776532 8353 H3 clustered histone 6 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C7 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.312169672 0.105363692 8968 H3 clustered histone 7 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C8 3.537500113 6.08973581 0.985264417 0.161790995 -2.627796782 0.2971307 1 0.621821846 0.104938838 8355 H3 clustered histone 8 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H4-16 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.499067371 0 121504 H4 histone 16 "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0003677,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006303,GO:0006334,GO:0006335,GO:0006336,GO:0006352,GO:0016020,GO:0016233,GO:0019904,GO:0032200,GO:0032991,GO:0034080,GO:0044267,GO:0045652,GO:0045653,GO:0045814,GO:0046982,GO:0060964,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|DNA-templated transcription, initiation|membrane|telomere capping|protein domain specific binding|telomere organization|protein-containing complex|CENP-A containing nucleosome assembly|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|extracellular exosome" "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H4C12 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.531306866 0 8362 H4 clustered histone 12 "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0003677,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006303,GO:0006334,GO:0006335,GO:0006336,GO:0006352,GO:0016020,GO:0016233,GO:0019904,GO:0032200,GO:0032991,GO:0034080,GO:0044267,GO:0045652,GO:0045653,GO:0045814,GO:0046982,GO:0060964,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|DNA-templated transcription, initiation|membrane|telomere capping|protein domain specific binding|telomere organization|protein-containing complex|CENP-A containing nucleosome assembly|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|extracellular exosome" "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H4C15 3.044867905 6.08973581 0 0 #NAME? 0.124110187 1 0.115861621 0 554313 H4 clustered histone 15 "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0003677,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006303,GO:0006334,GO:0006335,GO:0006336,GO:0006352,GO:0016020,GO:0016233,GO:0019904,GO:0032200,GO:0032991,GO:0034080,GO:0044267,GO:0045652,GO:0045653,GO:0045814,GO:0046982,GO:0060964,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|DNA-templated transcription, initiation|membrane|telomere capping|protein domain specific binding|telomere organization|protein-containing complex|CENP-A containing nucleosome assembly|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|extracellular exosome" "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H4C4 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.637765996 0 8360 H4 clustered histone 4 "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0003677,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006303,GO:0006334,GO:0006335,GO:0006336,GO:0006352,GO:0016020,GO:0016233,GO:0019904,GO:0032200,GO:0032991,GO:0034080,GO:0044267,GO:0045652,GO:0045653,GO:0045814,GO:0046982,GO:0060964,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|DNA-templated transcription, initiation|membrane|telomere capping|protein domain specific binding|telomere organization|protein-containing complex|CENP-A containing nucleosome assembly|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|extracellular exosome" "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H4C5 3.47811701 2.029911937 4.926322083 2.426864926 1.279093814 0.644064692 1 0.249533686 0.631670676 8367 H4 clustered histone 5 "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0003677,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006303,GO:0006334,GO:0006335,GO:0006336,GO:0006352,GO:0016020,GO:0016233,GO:0019904,GO:0032200,GO:0032991,GO:0034080,GO:0044267,GO:0045652,GO:0045653,GO:0045814,GO:0046982,GO:0060964,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|DNA-templated transcription, initiation|membrane|telomere capping|protein domain specific binding|telomere organization|protein-containing complex|CENP-A containing nucleosome assembly|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|extracellular exosome" "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H4C8 5.030242514 7.104691779 2.95579325 0.416033987 -1.265226703 0.543955984 1 0.879774021 0.381782374 8365 H4 clustered histone 8 "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0003677,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006303,GO:0006334,GO:0006335,GO:0006336,GO:0006352,GO:0016020,GO:0016233,GO:0019904,GO:0032200,GO:0032991,GO:0034080,GO:0044267,GO:0045652,GO:0045653,GO:0045814,GO:0046982,GO:0060964,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|DNA-templated transcription, initiation|membrane|telomere capping|protein domain specific binding|telomere organization|protein-containing complex|CENP-A containing nucleosome assembly|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|extracellular exosome" "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H4C9 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.647404776 0.131107465 8294 H4 clustered histone 9 "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0003677,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006303,GO:0006334,GO:0006335,GO:0006336,GO:0006352,GO:0016020,GO:0016233,GO:0019904,GO:0032200,GO:0032991,GO:0034080,GO:0044267,GO:0045652,GO:0045653,GO:0045814,GO:0046982,GO:0060964,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|DNA-templated transcription, initiation|membrane|telomere capping|protein domain specific binding|telomere organization|protein-containing complex|CENP-A containing nucleosome assembly|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|extracellular exosome" "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H6PD 1542.761026 1639.153889 1446.368163 0.882387049 -0.180516478 0.585485689 1 5.692749221 5.239587624 9563 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase "GO:0004345,GO:0005739,GO:0005788,GO:0006006,GO:0009051,GO:0017057,GO:0030246,GO:0047936,GO:0050661,GO:0097305,GO:2000064" "glucose-6-phosphate dehydrogenase activity|mitochondrion|endoplasmic reticulum lumen|glucose metabolic process|pentose-phosphate shunt, oxidative branch|6-phosphogluconolactonase activity|carbohydrate binding|glucose 1-dehydrogenase [NAD(P)] activity|NADP binding|response to alcohol|regulation of cortisol biosynthetic process" hsa00030 Pentose phosphate pathway HABP4 561.8446847 488.1938208 635.4955487 1.301727965 0.380427985 0.338445369 1 8.014682262 10.8823446 22927 hyaluronan binding protein 4 "GO:0002576,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0006397,GO:0008380,GO:0010494,GO:0015030,GO:0016528,GO:0016607,GO:0030017,GO:0030578,GO:0032183,GO:0033120,GO:0043392,GO:0045948,GO:0071260,GO:0097504" platelet degranulation|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|mRNA processing|RNA splicing|cytoplasmic stress granule|Cajal body|sarcoplasm|nuclear speck|sarcomere|PML body organization|SUMO binding|positive regulation of RNA splicing|negative regulation of DNA binding|positive regulation of translational initiation|cellular response to mechanical stimulus|Gemini of coiled bodies HACD1 460.394863 456.7301858 464.0595402 1.016047449 0.022967777 0.961764095 1 10.35905627 10.97867963 9200 3-hydroxyacyl-CoA dehydratase 1 "GO:0005515,GO:0005789,GO:0007275,GO:0018812,GO:0030148,GO:0030176,GO:0030497,GO:0035338,GO:0042761,GO:0102158,GO:0102343,GO:0102344,GO:0102345" protein binding|endoplasmic reticulum membrane|multicellular organism development|3-hydroxyacyl-CoA dehydratase activity|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACD2 985.8117342 980.4474654 991.176003 1.010942491 0.01570093 0.967686803 1 6.913017585 7.289706486 201562 3-hydroxyacyl-CoA dehydratase 2 "GO:0004725,GO:0005515,GO:0005783,GO:0005789,GO:0018812,GO:0019899,GO:0030148,GO:0030176,GO:0030497,GO:0035335,GO:0035338,GO:0042761,GO:0102158,GO:0102343,GO:0102344,GO:0102345" protein tyrosine phosphatase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|3-hydroxyacyl-CoA dehydratase activity|enzyme binding|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation|peptidyl-tyrosine dephosphorylation|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACD3 3873.477002 3496.523311 4250.430693 1.215616289 0.281687912 0.376635686 1 54.22124027 68.75145414 51495 3-hydroxyacyl-CoA dehydratase 3 "GO:0005096,GO:0005515,GO:0005783,GO:0005925,GO:0007249,GO:0007257,GO:0007264,GO:0016601,GO:0018812,GO:0019899,GO:0030148,GO:0030176,GO:0030497,GO:0031965,GO:0042761,GO:0043547,GO:0045070,GO:0046726,GO:0102158,GO:0102343,GO:0102344,GO:0102345" GTPase activator activity|protein binding|endoplasmic reticulum|focal adhesion|I-kappaB kinase/NF-kappaB signaling|activation of JUN kinase activity|small GTPase mediated signal transduction|Rac protein signal transduction|3-hydroxyacyl-CoA dehydratase activity|enzyme binding|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation|nuclear membrane|very long-chain fatty acid biosynthetic process|positive regulation of GTPase activity|positive regulation of viral genome replication|positive regulation by virus of viral protein levels in host cell|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACD4 384.0477571 322.7559979 445.3395163 1.379802449 0.464461726 0.290209972 1 1.866672683 2.686587644 401494 3-hydroxyacyl-CoA dehydratase 4 "GO:0005515,GO:0005783,GO:0018812,GO:0019899,GO:0030148,GO:0030176,GO:0030497,GO:0042761,GO:0102158,GO:0102343,GO:0102344,GO:0102345" protein binding|endoplasmic reticulum|3-hydroxyacyl-CoA dehydratase activity|enzyme binding|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation|very long-chain fatty acid biosynthetic process|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACE1 359.9236247 323.7709539 396.0762955 1.223322508 0.290804796 0.517426512 1 3.457275273 4.41154645 57531 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 "GO:0000139,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0006511,GO:0007030,GO:0007049,GO:0016567,GO:0016601,GO:0016604,GO:0030334,GO:0031267,GO:0032580,GO:0043161,GO:0045732,GO:0061025,GO:0061630,GO:0070936" Golgi membrane|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|ubiquitin-dependent protein catabolic process|Golgi organization|cell cycle|protein ubiquitination|Rac protein signal transduction|nuclear body|regulation of cell migration|small GTPase binding|Golgi cisterna membrane|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|membrane fusion|ubiquitin protein ligase activity|protein K48-linked ubiquitination HACL1 848.2082501 733.8131651 962.603335 1.311782591 0.391528634 0.281184807 1 18.49927729 25.31235512 26061 2-hydroxyacyl-CoA lyase 1 "GO:0000287,GO:0001561,GO:0005515,GO:0005524,GO:0005654,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006631,GO:0016830,GO:0030976,GO:0042802,GO:0043231,GO:0097089,GO:1903512" magnesium ion binding|fatty acid alpha-oxidation|protein binding|ATP binding|nucleoplasm|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid metabolic process|carbon-carbon lyase activity|thiamine pyrophosphate binding|identical protein binding|intracellular membrane-bounded organelle|methyl-branched fatty acid metabolic process|phytanic acid metabolic process hsa04146 Peroxisome HADH 672.8960102 670.8858951 674.9061253 1.00599242 0.008619435 0.986349087 1 15.72327804 16.49885222 3033 hydroxyacyl-CoA dehydrogenase "GO:0003857,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006635,GO:0016740,GO:0042802,GO:0050796,GO:0070403,GO:0120162" 3-hydroxyacyl-CoA dehydrogenase activity|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|transferase activity|identical protein binding|regulation of insulin secretion|NAD+ binding|positive regulation of cold-induced thermogenesis "hsa00062,hsa00071,hsa00280,hsa00310,hsa00380,hsa00650" "Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Butanoate metabolism" HADHA 3747.743704 3589.89926 3905.588147 1.087938091 0.121596462 0.702897035 1 61.77904625 70.10698843 3030 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha "GO:0003857,GO:0003985,GO:0004300,GO:0005515,GO:0005739,GO:0005743,GO:0006635,GO:0016507,GO:0016509,GO:0035965,GO:0042645" 3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|enoyl-CoA hydratase activity|protein binding|mitochondrion|mitochondrial inner membrane|fatty acid beta-oxidation|mitochondrial fatty acid beta-oxidation multienzyme complex|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|cardiolipin acyl-chain remodeling|mitochondrial nucleoid "hsa00062,hsa00071,hsa00280,hsa00310,hsa00380,hsa00410,hsa00640,hsa00650" "Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism" HADHB 1184.365279 1251.440709 1117.289848 0.892802863 -0.163586441 0.63424993 1 27.94579237 26.02483185 3032 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta "GO:0003723,GO:0003857,GO:0003988,GO:0004300,GO:0005515,GO:0005739,GO:0005740,GO:0005741,GO:0005743,GO:0005783,GO:0006635,GO:0035965,GO:0042645,GO:0050633" RNA binding|3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding|mitochondrion|mitochondrial envelope|mitochondrial outer membrane|mitochondrial inner membrane|endoplasmic reticulum|fatty acid beta-oxidation|cardiolipin acyl-chain remodeling|mitochondrial nucleoid|acetyl-CoA C-myristoyltransferase activity "hsa00062,hsa00071,hsa00280" "Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation" HAGH 635.6449981 549.0911789 722.1988173 1.315262101 0.395350323 0.305801486 1 10.0795691 13.82834487 3029 hydroxyacylglutathione hydrolase "GO:0004416,GO:0005515,GO:0005759,GO:0005829,GO:0006090,GO:0006750,GO:0019243,GO:0046872" hydroxyacylglutathione hydrolase activity|protein binding|mitochondrial matrix|cytosol|pyruvate metabolic process|glutathione biosynthetic process|methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione|metal ion binding hsa00620 Pyruvate metabolism HAGHL 131.536759 134.9891438 128.0843742 0.948849445 -0.075748904 0.914884872 1 3.760574213 3.721923147 84264 hydroxyacylglutathione hydrolase like "GO:0005515,GO:0016787,GO:0046872" protein binding|hydrolase activity|metal ion binding HAL 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.035304903 0.059580659 3034 histidine ammonia-lyase "GO:0004397,GO:0005829,GO:0006548,GO:0016841,GO:0019556,GO:0019557" histidine ammonia-lyase activity|cytosol|histidine catabolic process|ammonia-lyase activity|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate hsa00340 Histidine metabolism HAP1 17.06125638 21.31407534 12.80843742 0.600937982 -0.734711986 0.54859698 1 0.246569832 0.154555877 9001 huntingtin associated protein 1 "GO:0005102,GO:0005515,GO:0005730,GO:0005739,GO:0005764,GO:0005769,GO:0005776,GO:0005783,GO:0005813,GO:0005814,GO:0005829,GO:0005856,GO:0006605,GO:0006887,GO:0006914,GO:0007268,GO:0007420,GO:0008021,GO:0008089,GO:0008090,GO:0008104,GO:0015629,GO:0016234,GO:0017022,GO:0017157,GO:0021549,GO:0021979,GO:0022008,GO:0030030,GO:0030425,GO:0030426,GO:0031410,GO:0031587,GO:0032230,GO:0032901,GO:0043197,GO:0044325,GO:0045742,GO:0047496,GO:0048011,GO:0048311,GO:0048403,GO:0050769,GO:0098957,GO:1902430,GO:1902513,GO:1902857,GO:1904115" "signaling receptor binding|protein binding|nucleolus|mitochondrion|lysosome|early endosome|autophagosome|endoplasmic reticulum|centrosome|centriole|cytosol|cytoskeleton|protein targeting|exocytosis|autophagy|chemical synaptic transmission|brain development|synaptic vesicle|anterograde axonal transport|retrograde axonal transport|protein localization|actin cytoskeleton|inclusion body|myosin binding|regulation of exocytosis|cerebellum development|hypothalamus cell differentiation|neurogenesis|cell projection organization|dendrite|growth cone|cytoplasmic vesicle|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|positive regulation of synaptic transmission, GABAergic|positive regulation of neurotrophin production|dendritic spine|ion channel binding|positive regulation of epidermal growth factor receptor signaling pathway|vesicle transport along microtubule|neurotrophin TRK receptor signaling pathway|mitochondrion distribution|brain-derived neurotrophic factor binding|positive regulation of neurogenesis|anterograde axonal transport of mitochondrion|negative regulation of amyloid-beta formation|regulation of organelle transport along microtubule|positive regulation of non-motile cilium assembly|axon cytoplasm" "hsa04727,hsa05014,hsa05016,hsa05022" GABAergic synapse|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases HAPLN3 196.7220708 213.1407534 180.3033882 0.845935774 -0.241379961 0.661093163 1 5.167461581 4.559640239 145864 hyaluronan and proteoglycan link protein 3 "GO:0001501,GO:0005540,GO:0005615,GO:0007155,GO:0007417,GO:0031012" skeletal system development|hyaluronic acid binding|extracellular space|cell adhesion|central nervous system development|extracellular matrix HARBI1 98.27802283 117.7348923 78.82115332 0.66947998 -0.578887181 0.398227347 1 1.931602511 1.348873695 283254 harbinger transposase derived 1 "GO:0004518,GO:0005634,GO:0005829,GO:0005886,GO:0034451,GO:0046872,GO:0090305" nuclease activity|nucleus|cytosol|plasma membrane|centriolar satellite|metal ion binding|nucleic acid phosphodiester bond hydrolysis HARS1 2121.461848 2100.958855 2141.964842 1.019517749 0.027886891 0.932266329 1 54.62328247 58.08827972 3035 histidyl-tRNA synthetase 1 "GO:0004821,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006412,GO:0006418,GO:0006427,GO:0032543,GO:0042802,GO:0042803" histidine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrion|cytosol|translation|tRNA aminoacylation for protein translation|histidyl-tRNA aminoacylation|mitochondrial translation|identical protein binding|protein homodimerization activity hsa00970 Aminoacyl-tRNA biosynthesis HARS2 783.5910371 829.2190262 737.963048 0.889949488 -0.168204641 0.650130841 1 17.01662008 15.79627152 23438 "histidyl-tRNA synthetase 2, mitochondrial" "GO:0003723,GO:0004821,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006412,GO:0006418,GO:0006427,GO:0042802" RNA binding|histidine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|translation|tRNA aminoacylation for protein translation|histidyl-tRNA aminoacylation|identical protein binding hsa00970 Aminoacyl-tRNA biosynthesis HAS2 160.4063426 155.2882632 165.524422 1.065917144 0.092095299 0.883924707 1 1.854906298 2.062345166 3037 hyaluronan synthase 2 "GO:0001570,GO:0001822,GO:0005515,GO:0005887,GO:0008284,GO:0010838,GO:0014911,GO:0030213,GO:0030335,GO:0031410,GO:0035810,GO:0036120,GO:0036302,GO:0042802,GO:0044849,GO:0044853,GO:0045226,GO:0050501,GO:0051549,GO:0060349,GO:0070295,GO:0071347,GO:0071356,GO:0071498,GO:0085029,GO:0090500,GO:1900026,GO:1900127,GO:1900625,GO:1901201" vasculogenesis|kidney development|protein binding|integral component of plasma membrane|positive regulation of cell population proliferation|positive regulation of keratinocyte proliferation|positive regulation of smooth muscle cell migration|hyaluronan biosynthetic process|positive regulation of cell migration|cytoplasmic vesicle|positive regulation of urine volume|cellular response to platelet-derived growth factor stimulus|atrioventricular canal development|identical protein binding|estrous cycle|plasma membrane raft|extracellular polysaccharide biosynthetic process|hyaluronan synthase activity|positive regulation of keratinocyte migration|bone morphogenesis|renal water absorption|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to fluid shear stress|extracellular matrix assembly|endocardial cushion to mesenchymal transition|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of hyaluronan biosynthetic process|positive regulation of monocyte aggregation|regulation of extracellular matrix assembly HAS3 34.61514496 42.62815067 26.60213925 0.624050981 -0.680264202 0.480619339 1 0.435450877 0.283449157 3038 hyaluronan synthase 3 "GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0005975,GO:0016021,GO:0030213,GO:0036117,GO:0042802,GO:0045226,GO:0045893,GO:0050501,GO:0085029,GO:1900106" "protein binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|integral component of membrane|hyaluronan biosynthetic process|hyaluranon cable|identical protein binding|extracellular polysaccharide biosynthetic process|positive regulation of transcription, DNA-templated|hyaluronan synthase activity|extracellular matrix assembly|positive regulation of hyaluranon cable assembly" HASPIN 352.0415093 323.7709539 380.3120648 1.174633055 0.232210142 0.608828941 1 5.862658784 7.183114119 83903 histone H3 associated protein kinase "GO:0000278,GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005813,GO:0005819,GO:0006468,GO:0007064,GO:0035556,GO:0071459,GO:0072354,GO:0106310,GO:0106311,GO:2000751" "mitotic cell cycle|protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|cytoplasm|centrosome|spindle|protein phosphorylation|mitotic sister chromatid cohesion|intracellular signal transduction|protein localization to chromosome, centromeric region|histone kinase activity (H3-T3 specific)|protein serine kinase activity|protein threonine kinase activity|histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore" HAT1 1326.964117 1199.677955 1454.250279 1.212200552 0.277628405 0.410317607 1 23.36003698 29.53683338 8520 histone acetyltransferase 1 "GO:0000781,GO:0000785,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006323,GO:0006335,GO:0006336,GO:0006348,GO:0006475,GO:0007584,GO:0010485,GO:0016363,GO:0032991,GO:0042393,GO:0043967" "chromosome, telomeric region|chromatin|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA packaging|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|chromatin silencing at telomere|internal protein amino acid acetylation|response to nutrient|H4 histone acetyltransferase activity|nuclear matrix|protein-containing complex|histone binding|histone H4 acetylation" hsa05034 Alcoholism HAUS1 666.8441308 560.2556945 773.432567 1.380499252 0.465190106 0.223161062 1 26.4691926 38.11472576 115106 HAUS augmin like complex subunit 1 "GO:0000086,GO:0000922,GO:0003674,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|spindle pole|molecular_function|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS2 737.5671631 646.5269519 828.6073743 1.281628511 0.357978147 0.338199231 1 7.607878555 10.17048494 55142 HAUS augmin like complex subunit 2 "GO:0000086,GO:0003674,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|molecular_function|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS3 247.5495413 252.7240361 242.3750465 0.959050236 -0.060321708 0.912547958 1 2.177169735 2.177958373 79441 HAUS augmin like complex subunit 3 "GO:0000086,GO:0003674,GO:0005515,GO:0005654,GO:0005739,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0015630,GO:0045171,GO:0051225,GO:0051301,GO:0070652,GO:0072686,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|molecular_function|protein binding|nucleoplasm|mitochondrion|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|intercellular bridge|spindle assembly|cell division|HAUS complex|mitotic spindle|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS4 967.4183174 1002.776497 932.0601381 0.929479441 -0.105505139 0.768011875 1 32.02212609 31.04601631 54930 HAUS augmin like complex subunit 4 "GO:0000086,GO:0003674,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0051011,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|molecular_function|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|microtubule minus-end binding|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS5 389.8999605 318.6961741 461.1037469 1.446844313 0.532909689 0.222800306 1 3.832107532 5.783295967 23354 HAUS augmin like complex subunit 5 "GO:0000086,GO:0003674,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|molecular_function|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS6 1106.385137 1005.821365 1206.94891 1.199963485 0.262990505 0.448281123 1 7.44973732 9.324486406 54801 HAUS augmin like complex subunit 6 "GO:0000086,GO:0003674,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0016607,GO:0034451,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|molecular_function|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|nuclear speck|centriolar satellite|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS7 273.4957448 241.5595205 305.4319691 1.26441702 0.338472361 0.489098709 1 7.767706375 10.24469571 55559 HAUS augmin like complex subunit 7 "GO:0000086,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0031996,GO:0051011,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|thioesterase binding|microtubule minus-end binding|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS8 202.321896 191.826678 212.817114 1.109423966 0.149810797 0.787377926 1 6.542319541 7.570860176 93323 HAUS augmin like complex subunit 8 "GO:0000086,GO:0000922,GO:0003674,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005880,GO:0007098,GO:0008017,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|spindle pole|molecular_function|protein binding|cytoplasm|centrosome|cytosol|nuclear microtubule|centrosome cycle|microtubule binding|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAX1 1398.962648 1204.752734 1593.172562 1.322406263 0.403165463 0.228309587 1 55.01936509 75.89207053 10456 HCLS1 associated protein X-1 "GO:0000932,GO:0005515,GO:0005635,GO:0005667,GO:0005739,GO:0005741,GO:0005758,GO:0005783,GO:0005938,GO:0007005,GO:0014068,GO:0015629,GO:0016324,GO:0016529,GO:0019966,GO:0030027,GO:0030136,GO:0030833,GO:0030854,GO:0031965,GO:0033138,GO:0042981,GO:0043066,GO:0045944,GO:0047485,GO:0050731,GO:0051897,GO:0071345,GO:1903146,GO:1903214,GO:2000251" P-body|protein binding|nuclear envelope|transcription regulator complex|mitochondrion|mitochondrial outer membrane|mitochondrial intermembrane space|endoplasmic reticulum|cell cortex|mitochondrion organization|positive regulation of phosphatidylinositol 3-kinase signaling|actin cytoskeleton|apical plasma membrane|sarcoplasmic reticulum|interleukin-1 binding|lamellipodium|clathrin-coated vesicle|regulation of actin filament polymerization|positive regulation of granulocyte differentiation|nuclear membrane|positive regulation of peptidyl-serine phosphorylation|regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling|cellular response to cytokine stimulus|regulation of autophagy of mitochondrion|regulation of protein targeting to mitochondrion|positive regulation of actin cytoskeleton reorganization HBE1 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.082510336 0.417734059 3046 hemoglobin subunit epsilon 1 "GO:0004601,GO:0005344,GO:0005515,GO:0005829,GO:0005833,GO:0007596,GO:0014070,GO:0015671,GO:0019825,GO:0020037,GO:0031720,GO:0031721,GO:0031838,GO:0042744,GO:0043177,GO:0044877,GO:0046872,GO:0072562,GO:0098869" peroxidase activity|oxygen carrier activity|protein binding|cytosol|hemoglobin complex|blood coagulation|response to organic cyclic compound|oxygen transport|oxygen binding|heme binding|haptoglobin binding|hemoglobin alpha binding|haptoglobin-hemoglobin complex|hydrogen peroxide catabolic process|organic acid binding|protein-containing complex binding|metal ion binding|blood microparticle|cellular oxidant detoxification HBEGF 302.7607211 356.2495449 249.2718974 0.699711483 -0.515167927 0.274967063 1 7.651731415 5.584633129 1839 heparin binding EGF like growth factor "GO:0000165,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0005887,GO:0007165,GO:0007173,GO:0007517,GO:0008016,GO:0008083,GO:0008201,GO:0008284,GO:0009986,GO:0030307,GO:0030335,GO:0030665,GO:0030666,GO:0030669,GO:0035313,GO:0038128,GO:0042059,GO:0045741,GO:0048661,GO:0051545,GO:0051549,GO:0051897,GO:0060326,GO:0061024,GO:0090303,GO:2000145" "MAPK cascade|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|plasma membrane|integral component of plasma membrane|signal transduction|epidermal growth factor receptor signaling pathway|muscle organ development|regulation of heart contraction|growth factor activity|heparin binding|positive regulation of cell population proliferation|cell surface|positive regulation of cell growth|positive regulation of cell migration|clathrin-coated vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|wound healing, spreading of epidermal cells|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of smooth muscle cell proliferation|negative regulation of elastin biosynthetic process|positive regulation of keratinocyte migration|positive regulation of protein kinase B signaling|cell chemotaxis|membrane organization|positive regulation of wound healing|regulation of cell motility" "hsa01522,hsa04012,hsa04912,hsa04915,hsa04928,hsa05120,hsa05171,hsa05205,hsa05219" "Endocrine resistance|ErbB signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Parathyroid hormone synthesis, secretion and action|Epithelial cell signaling in Helicobacter pylori infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|Bladder cancer" HBP1 1347.521057 1190.543351 1504.498764 1.26370767 0.337662768 0.315455754 1 16.56961273 21.84112022 26959 HMG-box transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007050,GO:0016055,GO:0016607" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell cycle arrest|Wnt signaling pathway|nuclear speck" HMG HBS1L 988.0819002 967.2530379 1008.910763 1.043068073 0.060833315 0.865796528 1 5.21314825 5.671901206 10767 HBS1 like translational GTPase "GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0006412,GO:0006414,GO:0007165,GO:0016020,GO:0043928,GO:0070062" translation elongation factor activity|GTPase activity|protein binding|GTP binding|cytosol|translation|translational elongation|signal transduction|membrane|exonucleolytic catabolism of deadenylated mRNA|extracellular exosome "hsa03015,hsa05134" mRNA surveillance pathway|Legionellosis HCAR1 593.2677418 683.0653667 503.4701169 0.737074578 -0.440117495 0.261707971 1 7.25411011 5.577139475 27198 hydroxycarboxylic acid receptor 1 "GO:0004930,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane hsa04024 cAMP signaling pathway HCAR2 26.65880075 37.55337083 15.76423066 0.419782041 -1.252287647 0.224146092 1 0.921039105 0.403290373 338442 hydroxycarboxylic acid receptor 2 "GO:0001781,GO:0005886,GO:0007186,GO:0016021,GO:0030054,GO:0033031,GO:0050995,GO:0070165,GO:0070553" neutrophil apoptotic process|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|cell junction|positive regulation of neutrophil apoptotic process|negative regulation of lipid catabolic process|positive regulation of adiponectin secretion|nicotinic acid receptor activity hsa04024 cAMP signaling pathway HCAR3 52.92888972 82.21143344 23.646346 0.287628436 -1.797721783 0.034825695 0.836264269 2.025155194 0.607583623 8843 hydroxycarboxylic acid receptor 3 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0030054" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|cell junction hsa04024 cAMP signaling pathway HCCS 1568.95837 1476.760934 1661.155806 1.124864403 0.169751102 0.607430348 1 15.0246548 17.62871294 3052 holocytochrome c synthase "GO:0004408,GO:0005515,GO:0005739,GO:0005743,GO:0009887,GO:0016020,GO:0018063,GO:0018215,GO:0020037,GO:0046872,GO:0055114" holocytochrome-c synthase activity|protein binding|mitochondrion|mitochondrial inner membrane|animal organ morphogenesis|membrane|cytochrome c-heme linkage|protein phosphopantetheinylation|heme binding|metal ion binding|oxidation-reduction process hsa00860 Porphyrin and chlorophyll metabolism HCFC1 4797.289823 4684.021794 4910.557852 1.048363579 0.068139139 0.832120546 1 26.69695922 29.1937344 3054 host cell factor C1 "GO:0000122,GO:0000123,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0005737,GO:0006338,GO:0006355,GO:0007005,GO:0007049,GO:0010628,GO:0016020,GO:0016579,GO:0019046,GO:0030674,GO:0032991,GO:0033613,GO:0035097,GO:0042802,GO:0043025,GO:0043254,GO:0043981,GO:0043982,GO:0043984,GO:0045296,GO:0045787,GO:0045893,GO:0045944,GO:0048188,GO:0050821,GO:0070461,GO:0071339" "negative regulation of transcription by RNA polymerase II|histone acetyltransferase complex|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|chromatin remodeling|regulation of transcription, DNA-templated|mitochondrion organization|cell cycle|positive regulation of gene expression|membrane|protein deubiquitination|release from viral latency|protein-macromolecule adaptor activity|protein-containing complex|activating transcription factor binding|histone methyltransferase complex|identical protein binding|neuronal cell body|regulation of protein-containing complex assembly|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|cadherin binding|positive regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|Set1C/COMPASS complex|protein stabilization|SAGA-type complex|MLL1 complex" hsa05168 Herpes simplex virus 1 infection other HCFC1R1 893.8634552 1228.096722 559.6301886 0.455689018 -1.133878494 0.001792866 0.132156273 81.09356778 38.54525291 54985 host cell factor C1 regulator 1 "GO:0005654,GO:0005737" nucleoplasm|cytoplasm HCFC2 241.2343972 258.8137719 223.6550226 0.864154256 -0.210639231 0.682620966 1 2.136942372 1.926193945 29915 host cell factor C2 "GO:0000122,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006338,GO:0006355,GO:0006357,GO:0016032,GO:0016604,GO:0035097,GO:0045893,GO:0071339" "negative regulation of transcription by RNA polymerase II|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|chromatin remodeling|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|viral process|nuclear body|histone methyltransferase complex|positive regulation of transcription, DNA-templated|MLL1 complex" hsa05168 Herpes simplex virus 1 infection HCLS1 26.09193966 32.47859099 19.70528833 0.606716232 -0.720906186 0.494172706 1 0.825766092 0.522586985 3059 hematopoietic cell-specific Lyn substrate 1 "GO:0000122,GO:0001085,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0005739,GO:0005829,GO:0005884,GO:0005886,GO:0006355,GO:0008284,GO:0009725,GO:0014068,GO:0017124,GO:0019901,GO:0030041,GO:0030218,GO:0030427,GO:0030833,GO:0030854,GO:0030864,GO:0033138,GO:0035556,GO:0042307,GO:0042531,GO:0045651,GO:0045944,GO:0050731,GO:0051015,GO:0051091,GO:0051897,GO:0071345,GO:2000107,GO:2000251" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|protein binding|nucleus|transcription regulator complex|cytoplasm|mitochondrion|cytosol|actin filament|plasma membrane|regulation of transcription, DNA-templated|positive regulation of cell population proliferation|response to hormone|positive regulation of phosphatidylinositol 3-kinase signaling|SH3 domain binding|protein kinase binding|actin filament polymerization|erythrocyte differentiation|site of polarized growth|regulation of actin filament polymerization|positive regulation of granulocyte differentiation|cortical actin cytoskeleton|positive regulation of peptidyl-serine phosphorylation|intracellular signal transduction|positive regulation of protein import into nucleus|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of macrophage differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of peptidyl-tyrosine phosphorylation|actin filament binding|positive regulation of DNA-binding transcription factor activity|positive regulation of protein kinase B signaling|cellular response to cytokine stimulus|negative regulation of leukocyte apoptotic process|positive regulation of actin cytoskeleton reorganization" "hsa04530,hsa05100,hsa05130,hsa05131,hsa05205" Tight junction|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Proteoglycans in cancer HCN2 475.8446107 468.9096574 482.7795641 1.02957906 0.042054616 0.924225365 1 6.944040916 7.457407958 610 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 "GO:0005222,GO:0005248,GO:0005249,GO:0005515,GO:0005886,GO:0005887,GO:0007267,GO:0008076,GO:0030552,GO:0034765,GO:0035725,GO:0042391,GO:0042802,GO:0071320,GO:0071321,GO:0071805,GO:0086012,GO:0098719,GO:0098855,GO:1990573" intracellular cAMP-activated cation channel activity|voltage-gated sodium channel activity|voltage-gated potassium channel activity|protein binding|plasma membrane|integral component of plasma membrane|cell-cell signaling|voltage-gated potassium channel complex|cAMP binding|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|identical protein binding|cellular response to cAMP|cellular response to cGMP|potassium ion transmembrane transport|membrane depolarization during cardiac muscle cell action potential|sodium ion import across plasma membrane|HCN channel complex|potassium ion import across plasma membrane "hsa04024,hsa04929" cAMP signaling pathway|GnRH secretion HCN3 307.9354621 238.5146526 377.3562715 1.58210939 0.661849354 0.158648835 1 2.463280123 4.065053263 57657 hyperpolarization activated cyclic nucleotide gated potassium channel 3 "GO:0005248,GO:0005249,GO:0005515,GO:0005886,GO:0005887,GO:0030425,GO:0030552,GO:0034765,GO:0035725,GO:0042391,GO:0043025,GO:0044316,GO:0071320,GO:0071805,GO:0072718,GO:1903351" voltage-gated sodium channel activity|voltage-gated potassium channel activity|protein binding|plasma membrane|integral component of plasma membrane|dendrite|cAMP binding|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|neuronal cell body|cone cell pedicle|cellular response to cAMP|potassium ion transmembrane transport|response to cisplatin|cellular response to dopamine hsa04929 GnRH secretion HCN4 15.50913087 16.23929549 14.77896625 0.910074347 -0.135943686 0.968727396 1 0.118034304 0.112047209 10021 hyperpolarization activated cyclic nucleotide gated potassium channel 4 "GO:0002027,GO:0003254,GO:0005222,GO:0005248,GO:0005249,GO:0005886,GO:0006812,GO:0006936,GO:0008015,GO:0030552,GO:0031226,GO:0034765,GO:0035725,GO:0042391,GO:0042802,GO:0048471,GO:0055117,GO:0071320,GO:0071321,GO:0071805,GO:0086012,GO:0086015,GO:0086041,GO:0086046,GO:0086091,GO:0098719,GO:0098855,GO:0098909,GO:1990573" regulation of heart rate|regulation of membrane depolarization|intracellular cAMP-activated cation channel activity|voltage-gated sodium channel activity|voltage-gated potassium channel activity|plasma membrane|cation transport|muscle contraction|blood circulation|cAMP binding|intrinsic component of plasma membrane|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|identical protein binding|perinuclear region of cytoplasm|regulation of cardiac muscle contraction|cellular response to cAMP|cellular response to cGMP|potassium ion transmembrane transport|membrane depolarization during cardiac muscle cell action potential|SA node cell action potential|voltage-gated potassium channel activity involved in SA node cell action potential depolarization|membrane depolarization during SA node cell action potential|regulation of heart rate by cardiac conduction|sodium ion import across plasma membrane|HCN channel complex|regulation of cardiac muscle cell action potential involved in regulation of contraction|potassium ion import across plasma membrane "hsa04024,hsa04742" cAMP signaling pathway|Taste transduction HCST 4.537610306 7.104691779 1.970528833 0.277355992 -1.850189203 0.383956367 1 0.423326559 0.122469797 10870 hematopoietic cell signal transducer "GO:0005102,GO:0005515,GO:0005886,GO:0006468,GO:0009986,GO:0014068,GO:0016021,GO:0043548,GO:0050776" signaling receptor binding|protein binding|plasma membrane|protein phosphorylation|cell surface|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|phosphatidylinositol 3-kinase binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity HDAC1 3178.991282 3235.679627 3122.302936 0.964960471 -0.051458251 0.872322167 1 65.52409369 65.95177301 3065 histone deacetylase 1 "GO:0000118,GO:0000122,GO:0000785,GO:0000792,GO:0000978,GO:0000979,GO:0001046,GO:0001085,GO:0001103,GO:0002039,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0006338,GO:0006346,GO:0006357,GO:0006476,GO:0007492,GO:0007596,GO:0008134,GO:0008284,GO:0009913,GO:0010629,GO:0010832,GO:0016575,GO:0016580,GO:0016581,GO:0019213,GO:0019899,GO:0021766,GO:0030182,GO:0031492,GO:0032041,GO:0032922,GO:0032991,GO:0033558,GO:0033613,GO:0035851,GO:0042475,GO:0042733,GO:0042826,GO:0043025,GO:0043044,GO:0043066,GO:0043124,GO:0043922,GO:0045652,GO:0045892,GO:0045893,GO:0045944,GO:0047485,GO:0048714,GO:0051059,GO:0052548,GO:0060766,GO:0060789,GO:0061029,GO:0061198,GO:0070491,GO:0070888,GO:0070932,GO:0070933,GO:0090090,GO:1900221,GO:1901796,GO:1904837,GO:1990841,GO:2000273,GO:2001243" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|core promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|RNA polymerase II repressing transcription factor binding|p53 binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin organization|chromatin remodeling|DNA methylation-dependent heterochromatin assembly|regulation of transcription by RNA polymerase II|protein deacetylation|endoderm development|blood coagulation|transcription factor binding|positive regulation of cell population proliferation|epidermal cell differentiation|negative regulation of gene expression|negative regulation of myotube differentiation|histone deacetylation|Sin3 complex|NuRD complex|deacetylase activity|enzyme binding|hippocampus development|neuron differentiation|nucleosomal DNA binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|circadian regulation of gene expression|protein-containing complex|protein deacetylase activity|activating transcription factor binding|Krueppel-associated box domain binding|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|histone deacetylase binding|neuronal cell body|ATP-dependent chromatin remodeling|negative regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation by host of viral transcription|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|positive regulation of oligodendrocyte differentiation|NF-kappaB binding|regulation of endopeptidase activity|negative regulation of androgen receptor signaling pathway|hair follicle placode formation|eyelid development in camera-type eye|fungiform papilla formation|repressing transcription factor binding|E-box binding|histone H3 deacetylation|histone H4 deacetylation|negative regulation of canonical Wnt signaling pathway|regulation of amyloid-beta clearance|regulation of signal transduction by p53 class mediator|beta-catenin-TCF complex assembly|promoter-specific chromatin binding|positive regulation of signaling receptor activity|negative regulation of intrinsic apoptotic signaling pathway" "hsa04110,hsa04213,hsa04330,hsa04919,hsa05016,hsa05031,hsa05034,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05206,hsa05220" Cell cycle|Longevity regulating pathway - multiple species|Notch signaling pathway|Thyroid hormone signaling pathway|Huntington disease|Amphetamine addiction|Alcoholism|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Chronic myeloid leukemia chromosome_remodelling_factor HDAC10 428.1416802 373.5037964 482.7795641 1.292569363 0.370241702 0.385035678 1 7.369166203 9.93546366 83933 histone deacetylase 10 "GO:0000118,GO:0000122,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006325,GO:0006355,GO:0006476,GO:0008270,GO:0014003,GO:0016236,GO:0016575,GO:0019213,GO:0019899,GO:0032425,GO:0033558,GO:0034983,GO:0035825,GO:0042826,GO:0045892,GO:0047609,GO:0047611,GO:0106047,GO:0106048" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|chromatin organization|regulation of transcription, DNA-templated|protein deacetylation|zinc ion binding|oligodendrocyte development|macroautophagy|histone deacetylation|deacetylase activity|enzyme binding|positive regulation of mismatch repair|protein deacetylase activity|peptidyl-lysine deacetylation|homologous recombination|histone deacetylase binding|negative regulation of transcription, DNA-templated|acetylputrescine deacetylase activity|acetylspermidine deacetylase activity|polyamine deacetylation|spermidine deacetylation" "hsa05034,hsa05203" Alcoholism|Viral carcinogenesis HDAC11 351.3437579 276.0680234 426.6194924 1.545341931 0.627926092 0.163669455 1 2.936750993 4.733775338 79885 histone deacetylase 11 "GO:0000118,GO:0004407,GO:0005515,GO:0005634,GO:0005886,GO:0006325,GO:0008134,GO:0014003,GO:0016575,GO:0032041,GO:0070932" histone deacetylase complex|histone deacetylase activity|protein binding|nucleus|plasma membrane|chromatin organization|transcription factor binding|oligodendrocyte development|histone deacetylation|NAD-dependent histone deacetylase activity (H3-K14 specific)|histone H3 deacetylation "hsa05034,hsa05203" Alcoholism|Viral carcinogenesis HDAC2 1698.629758 1787.33746 1609.922057 0.900737601 -0.150821207 0.645292867 1 9.007197713 8.46260204 3066 histone deacetylase 2 "GO:0000118,GO:0000122,GO:0000785,GO:0001103,GO:0001975,GO:0003300,GO:0003682,GO:0003723,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006338,GO:0007596,GO:0008134,GO:0008284,GO:0009913,GO:0010718,GO:0010977,GO:0016358,GO:0016575,GO:0016580,GO:0016581,GO:0019213,GO:0019899,GO:0031000,GO:0031072,GO:0031492,GO:0032041,GO:0032496,GO:0032732,GO:0032760,GO:0032922,GO:0032967,GO:0032991,GO:0033558,GO:0034605,GO:0035094,GO:0035098,GO:0042220,GO:0042475,GO:0042493,GO:0042531,GO:0042733,GO:0042826,GO:0043044,GO:0043066,GO:0043392,GO:0043433,GO:0043565,GO:0045347,GO:0045862,GO:0045892,GO:0045893,GO:0045944,GO:0048149,GO:0048714,GO:0051059,GO:0055093,GO:0060789,GO:0061000,GO:0061029,GO:0061198,GO:0070301,GO:0070829,GO:0070932,GO:0070933,GO:0071300,GO:0071560,GO:1901796,GO:1902437,GO:1903351,GO:1990841,GO:2000273,GO:2000757" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II repressing transcription factor binding|response to amphetamine|cardiac muscle hypertrophy|chromatin binding|RNA binding|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|chromatin remodeling|blood coagulation|transcription factor binding|positive regulation of cell population proliferation|epidermal cell differentiation|positive regulation of epithelial to mesenchymal transition|negative regulation of neuron projection development|dendrite development|histone deacetylation|Sin3 complex|NuRD complex|deacetylase activity|enzyme binding|response to caffeine|heat shock protein binding|nucleosomal DNA binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|response to lipopolysaccharide|positive regulation of interleukin-1 production|positive regulation of tumor necrosis factor production|circadian regulation of gene expression|positive regulation of collagen biosynthetic process|protein-containing complex|protein deacetylase activity|cellular response to heat|response to nicotine|ESC/E(Z) complex|response to cocaine|odontogenesis of dentin-containing tooth|response to drug|positive regulation of tyrosine phosphorylation of STAT protein|embryonic digit morphogenesis|histone deacetylase binding|ATP-dependent chromatin remodeling|negative regulation of apoptotic process|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|negative regulation of MHC class II biosynthetic process|positive regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|behavioral response to ethanol|positive regulation of oligodendrocyte differentiation|NF-kappaB binding|response to hyperoxia|hair follicle placode formation|negative regulation of dendritic spine development|eyelid development in camera-type eye|fungiform papilla formation|cellular response to hydrogen peroxide|heterochromatin maintenance|histone H3 deacetylation|histone H4 deacetylation|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|regulation of signal transduction by p53 class mediator|positive regulation of male mating behavior|cellular response to dopamine|promoter-specific chromatin binding|positive regulation of signaling receptor activity|negative regulation of peptidyl-lysine acetylation" "hsa04110,hsa04213,hsa04330,hsa04919,hsa05016,hsa05031,hsa05034,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05206,hsa05220" Cell cycle|Longevity regulating pathway - multiple species|Notch signaling pathway|Thyroid hormone signaling pathway|Huntington disease|Amphetamine addiction|Alcoholism|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Chronic myeloid leukemia chromosome_remodelling_factor HDAC3 2117.222391 2282.635973 1951.808809 0.855067927 -0.225889062 0.481986651 1 50.72727484 45.24369627 8841 histone deacetylase 3 "GO:0000118,GO:0000122,GO:0001226,GO:0001934,GO:0003682,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006325,GO:0006476,GO:0007623,GO:0008134,GO:0010832,GO:0017053,GO:0019216,GO:0019899,GO:0030332,GO:0031398,GO:0031647,GO:0032008,GO:0032041,GO:0032922,GO:0033558,GO:0042307,GO:0042752,GO:0042826,GO:0043066,GO:0045892,GO:0045944,GO:0046329,GO:0051059,GO:0051225,GO:0070932,GO:0070933,GO:0071498,GO:0072686,GO:0120162" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|positive regulation of protein phosphorylation|chromatin binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|chromatin organization|protein deacetylation|circadian rhythm|transcription factor binding|negative regulation of myotube differentiation|transcription repressor complex|regulation of lipid metabolic process|enzyme binding|cyclin binding|positive regulation of protein ubiquitination|regulation of protein stability|positive regulation of TOR signaling|NAD-dependent histone deacetylase activity (H3-K14 specific)|circadian regulation of gene expression|protein deacetylase activity|positive regulation of protein import into nucleus|regulation of circadian rhythm|histone deacetylase binding|negative regulation of apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|NF-kappaB binding|spindle assembly|histone H3 deacetylation|histone H4 deacetylation|cellular response to fluid shear stress|mitotic spindle|positive regulation of cold-induced thermogenesis" "hsa04919,hsa05034,hsa05203" Thyroid hormone signaling pathway|Alcoholism|Viral carcinogenesis other HDAC4 196.5884588 204.0061496 189.170768 0.927279733 -0.108923472 0.849023697 1 0.41720944 0.403534643 9759 histone deacetylase 4 "GO:0000118,GO:0000122,GO:0000976,GO:0000978,GO:0001085,GO:0001501,GO:0002076,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006338,GO:0006476,GO:0006954,GO:0007399,GO:0008134,GO:0008270,GO:0008284,GO:0008285,GO:0010592,GO:0010832,GO:0010882,GO:0014894,GO:0014898,GO:0014911,GO:0016575,GO:0016607,GO:0016925,GO:0017053,GO:0019789,GO:0019901,GO:0030018,GO:0030183,GO:0030955,GO:0031594,GO:0031672,GO:0032041,GO:0033235,GO:0033558,GO:0033613,GO:0034983,GO:0040029,GO:0042113,GO:0042493,GO:0042641,GO:0042802,GO:0042826,GO:0043393,GO:0043433,GO:0043525,GO:0043565,GO:0045668,GO:0045820,GO:0045892,GO:0045893,GO:0045944,GO:0048661,GO:0048742,GO:0051091,GO:0070491,GO:0070555,GO:0070932,GO:0070933,GO:0071260,GO:0071356,GO:0071374,GO:1902437,GO:1902894,GO:1903428,GO:1990841" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding|skeletal system development|osteoblast development|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin remodeling|protein deacetylation|inflammatory response|nervous system development|transcription factor binding|zinc ion binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|positive regulation of lamellipodium assembly|negative regulation of myotube differentiation|regulation of cardiac muscle contraction by calcium ion signaling|response to denervation involved in regulation of muscle adaptation|cardiac muscle hypertrophy in response to stress|positive regulation of smooth muscle cell migration|histone deacetylation|nuclear speck|protein sumoylation|transcription repressor complex|SUMO transferase activity|protein kinase binding|Z disc|B cell differentiation|potassium ion binding|neuromuscular junction|A band|NAD-dependent histone deacetylase activity (H3-K14 specific)|positive regulation of protein sumoylation|protein deacetylase activity|activating transcription factor binding|peptidyl-lysine deacetylation|regulation of gene expression, epigenetic|B cell activation|response to drug|actomyosin|identical protein binding|histone deacetylase binding|regulation of protein binding|negative regulation of DNA-binding transcription factor activity|positive regulation of neuron apoptotic process|sequence-specific DNA binding|negative regulation of osteoblast differentiation|negative regulation of glycolytic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle cell proliferation|regulation of skeletal muscle fiber development|positive regulation of DNA-binding transcription factor activity|repressing transcription factor binding|response to interleukin-1|histone H3 deacetylation|histone H4 deacetylation|cellular response to mechanical stimulus|cellular response to tumor necrosis factor|cellular response to parathyroid hormone stimulus|positive regulation of male mating behavior|negative regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of reactive oxygen species biosynthetic process|promoter-specific chromatin binding" "hsa04371,hsa05034,hsa05203,hsa05206" Apelin signaling pathway|Alcoholism|Viral carcinogenesis|MicroRNAs in cancer HDAC5 1232.561087 976.3876416 1488.734533 1.524737174 0.60856058 0.074495501 1 8.794342799 13.98666937 10014 histone deacetylase 5 "GO:0000118,GO:0000122,GO:0000976,GO:0000978,GO:0001085,GO:0003682,GO:0004407,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006325,GO:0006338,GO:0006342,GO:0006476,GO:0006954,GO:0008134,GO:0010830,GO:0010832,GO:0014823,GO:0016575,GO:0016607,GO:0030182,GO:0030183,GO:0032041,GO:0032869,GO:0033558,GO:0040029,GO:0042113,GO:0042220,GO:0042493,GO:0042802,GO:0042826,GO:0043393,GO:0045892,GO:0045944,GO:0046872,GO:0051091,GO:0070491,GO:0070932,GO:0071222,GO:0090051,GO:2000615" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding|chromatin binding|histone deacetylase activity|protein kinase C binding|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|chromatin organization|chromatin remodeling|chromatin silencing|protein deacetylation|inflammatory response|transcription factor binding|regulation of myotube differentiation|negative regulation of myotube differentiation|response to activity|histone deacetylation|nuclear speck|neuron differentiation|B cell differentiation|NAD-dependent histone deacetylase activity (H3-K14 specific)|cellular response to insulin stimulus|protein deacetylase activity|regulation of gene expression, epigenetic|B cell activation|response to cocaine|response to drug|identical protein binding|histone deacetylase binding|regulation of protein binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of DNA-binding transcription factor activity|repressing transcription factor binding|histone H3 deacetylation|cellular response to lipopolysaccharide|negative regulation of cell migration involved in sprouting angiogenesis|regulation of histone H3-K9 acetylation" "hsa04371,hsa05034,hsa05203,hsa05206" Apelin signaling pathway|Alcoholism|Viral carcinogenesis|MicroRNAs in cancer HDAC6 1199.507471 1006.836321 1392.178621 1.382725863 0.467515159 0.171939384 1 9.236136159 13.32116914 10013 histone deacetylase 6 "GO:0000118,GO:0000209,GO:0000978,GO:0001226,GO:0003779,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005771,GO:0005829,GO:0005874,GO:0005875,GO:0005901,GO:0006476,GO:0006515,GO:0006886,GO:0006914,GO:0007026,GO:0008013,GO:0008017,GO:0008270,GO:0010506,GO:0010634,GO:0010727,GO:0016234,GO:0016235,GO:0016241,GO:0016575,GO:0019899,GO:0030286,GO:0030424,GO:0030425,GO:0031252,GO:0031333,GO:0031593,GO:0031625,GO:0031647,GO:0031648,GO:0032041,GO:0032418,GO:0032984,GO:0033138,GO:0033558,GO:0034983,GO:0035967,GO:0040029,GO:0042826,GO:0042903,GO:0043014,GO:0043130,GO:0043162,GO:0043204,GO:0043242,GO:0045598,GO:0045861,GO:0045892,GO:0047611,GO:0048156,GO:0048471,GO:0048487,GO:0048668,GO:0051354,GO:0051646,GO:0051787,GO:0051788,GO:0051879,GO:0060271,GO:0060632,GO:0060765,GO:0060997,GO:0061734,GO:0070201,GO:0070301,GO:0070840,GO:0070842,GO:0070845,GO:0070846,GO:0070848,GO:0070932,GO:0071218,GO:0090042,GO:0106047,GO:0106048,GO:1901300,GO:1903146,GO:2000273" "histone deacetylase complex|protein polyubiquitination|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II transcription corepressor binding|actin binding|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|multivesicular body|cytosol|microtubule|microtubule associated complex|caveola|protein deacetylation|protein quality control for misfolded or incompletely synthesized proteins|intracellular protein transport|autophagy|negative regulation of microtubule depolymerization|beta-catenin binding|microtubule binding|zinc ion binding|regulation of autophagy|positive regulation of epithelial cell migration|negative regulation of hydrogen peroxide metabolic process|inclusion body|aggresome|regulation of macroautophagy|histone deacetylation|enzyme binding|dynein complex|axon|dendrite|cell leading edge|negative regulation of protein-containing complex assembly|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|regulation of protein stability|protein destabilization|NAD-dependent histone deacetylase activity (H3-K14 specific)|lysosome localization|protein-containing complex disassembly|positive regulation of peptidyl-serine phosphorylation|protein deacetylase activity|peptidyl-lysine deacetylation|cellular response to topologically incorrect protein|regulation of gene expression, epigenetic|histone deacetylase binding|tubulin deacetylase activity|alpha-tubulin binding|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|perikaryon|negative regulation of protein-containing complex disassembly|regulation of fat cell differentiation|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|acetylspermidine deacetylase activity|tau protein binding|perinuclear region of cytoplasm|beta-tubulin binding|collateral sprouting|negative regulation of oxidoreductase activity|mitochondrion localization|misfolded protein binding|response to misfolded protein|Hsp90 protein binding|cilium assembly|regulation of microtubule-based movement|regulation of androgen receptor signaling pathway|dendritic spine morphogenesis|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|regulation of establishment of protein localization|cellular response to hydrogen peroxide|dynein complex binding|aggresome assembly|polyubiquitinated misfolded protein transport|Hsp90 deacetylation|response to growth factor|histone H3 deacetylation|cellular response to misfolded protein|tubulin deacetylation|polyamine deacetylation|spermidine deacetylation|positive regulation of hydrogen peroxide-mediated programmed cell death|regulation of autophagy of mitochondrion|positive regulation of signaling receptor activity" "hsa05014,hsa05034,hsa05203" Amyotrophic lateral sclerosis|Alcoholism|Viral carcinogenesis other HDAC7 1776.414429 1682.796996 1870.031863 1.111264084 0.152201704 0.640746828 1 14.47727727 16.78108743 51564 histone deacetylase 7 "GO:0000118,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006476,GO:0019901,GO:0032041,GO:0032703,GO:0033558,GO:0033613,GO:0045668,GO:0046872,GO:0070491,GO:0070932,GO:0071889,GO:0090050,GO:1901223" histone deacetylase complex|protein kinase C binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein deacetylation|protein kinase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|negative regulation of interleukin-2 production|protein deacetylase activity|activating transcription factor binding|negative regulation of osteoblast differentiation|metal ion binding|repressing transcription factor binding|histone H3 deacetylation|14-3-3 protein binding|positive regulation of cell migration involved in sprouting angiogenesis|negative regulation of NIK/NF-kappaB signaling "hsa05034,hsa05203" Alcoholism|Viral carcinogenesis HDAC8 597.3505762 591.7193296 602.9818229 1.019033506 0.027201488 0.94913282 1 8.23536592 8.753612033 55869 histone deacetylase 8 "GO:0000118,GO:0000122,GO:0000228,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006325,GO:0006333,GO:0007062,GO:0008134,GO:0030544,GO:0031397,GO:0031647,GO:0032041,GO:0032204,GO:0045944,GO:0046872,GO:0051879,GO:0070932,GO:0070933,GO:0071922" histone deacetylase complex|negative regulation of transcription by RNA polymerase II|nuclear chromosome|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|chromatin organization|chromatin assembly or disassembly|sister chromatid cohesion|transcription factor binding|Hsp70 protein binding|negative regulation of protein ubiquitination|regulation of protein stability|NAD-dependent histone deacetylase activity (H3-K14 specific)|regulation of telomere maintenance|positive regulation of transcription by RNA polymerase II|metal ion binding|Hsp90 protein binding|histone H3 deacetylation|histone H4 deacetylation|regulation of cohesin loading "hsa05034,hsa05203" Alcoholism|Viral carcinogenesis chromosome_remodelling_factor HDAC9 311.4553948 277.0829794 345.8278102 1.248101962 0.319735798 0.495830815 1 1.03658409 1.349492684 9734 histone deacetylase 9 "GO:0000118,GO:0000122,GO:0001818,GO:0001975,GO:0003714,GO:0004407,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006954,GO:0007507,GO:0008134,GO:0016575,GO:0030182,GO:0030183,GO:0032041,GO:0032869,GO:0033558,GO:0034739,GO:0034983,GO:0035097,GO:0042113,GO:0042632,GO:0042826,GO:0045892,GO:0046872,GO:0048742,GO:0051005,GO:0051153,GO:0070491,GO:0070932,GO:0070933,GO:0090050,GO:1990678" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|negative regulation of cytokine production|response to amphetamine|transcription corepressor activity|histone deacetylase activity|protein kinase C binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|inflammatory response|heart development|transcription factor binding|histone deacetylation|neuron differentiation|B cell differentiation|NAD-dependent histone deacetylase activity (H3-K14 specific)|cellular response to insulin stimulus|protein deacetylase activity|histone deacetylase activity (H4-K16 specific)|peptidyl-lysine deacetylation|histone methyltransferase complex|B cell activation|cholesterol homeostasis|histone deacetylase binding|negative regulation of transcription, DNA-templated|metal ion binding|regulation of skeletal muscle fiber development|negative regulation of lipoprotein lipase activity|regulation of striated muscle cell differentiation|repressing transcription factor binding|histone H3 deacetylation|histone H4 deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|histone H4-K16 deacetylation" "hsa05034,hsa05203" Alcoholism|Viral carcinogenesis HDDC2 223.9598568 290.277407 157.6423066 0.543074669 -0.880777523 0.090830832 1 9.008288373 5.102908207 51020 HD domain containing 2 "GO:0002953,GO:0005515,GO:0005737,GO:0016311,GO:0046872" 5'-deoxynucleotidase activity|protein binding|cytoplasm|dephosphorylation|metal ion binding HDDC3 195.3629404 221.2604011 169.4654796 0.765909665 -0.384753851 0.481116653 1 5.528396032 4.416646353 374659 HD domain containing 3 "GO:0005515,GO:0008893,GO:0046872" "protein binding|guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity|metal ion binding" hsa00230 Purine metabolism HDGF 10319.99406 10396.19398 10243.79414 0.985340804 -0.021305293 0.949929246 1 156.9858526 161.34775 3068 heparin binding growth factor "GO:0000122,GO:0000166,GO:0001222,GO:0003690,GO:0003712,GO:0003714,GO:0003723,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007165,GO:0008083,GO:0008201,GO:0017053,GO:0036498,GO:0062023,GO:0098761" negative regulation of transcription by RNA polymerase II|nucleotide binding|transcription corepressor binding|double-stranded DNA binding|transcription coregulator activity|transcription corepressor activity|RNA binding|extracellular region|extracellular space|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|signal transduction|growth factor activity|heparin binding|transcription repressor complex|IRE1-mediated unfolded protein response|collagen-containing extracellular matrix|cellular response to interleukin-7 HDGFL2 1725.613929 1678.737172 1772.490685 1.055847643 0.078401671 0.811507211 1 29.6554292 32.6603924 84717 HDGF like 2 "GO:0003690,GO:0003712,GO:0005515,GO:0005634,GO:0006357,GO:0030307" double-stranded DNA binding|transcription coregulator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of cell growth HDGFL3 1544.204034 1333.652142 1754.755926 1.315752339 0.39588796 0.230941227 1 4.345951369 5.964512358 50810 HDGF like 3 "GO:0003690,GO:0003712,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007026,GO:0007165,GO:0008017,GO:0008083,GO:0015631,GO:0031175,GO:0046785" double-stranded DNA binding|transcription coregulator activity|extracellular region|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|negative regulation of microtubule depolymerization|signal transduction|microtubule binding|growth factor activity|tubulin binding|neuron projection development|microtubule polymerization HDHD2 574.4398381 540.9715311 607.908145 1.123734078 0.168300675 0.67246837 1 5.256772759 6.161673543 84064 haloacid dehalogenase like hydrolase domain containing 2 "GO:0005515,GO:0008150,GO:0016311,GO:0016791,GO:0019899,GO:0046872,GO:0070062" protein binding|biological_process|dephosphorylation|phosphatase activity|enzyme binding|metal ion binding|extracellular exosome HDHD3 324.899479 354.219633 295.579325 0.834452124 -0.261098817 0.573979068 1 7.119037618 6.196388537 81932 haloacid dehalogenase like hydrolase domain containing 3 "GO:0005515,GO:0005730,GO:0016787,GO:0043231" protein binding|nucleolus|hydrolase activity|intracellular membrane-bounded organelle HDHD5 772.3441277 902.2958559 642.3923996 0.711953175 -0.490145736 0.185409204 1 13.84371463 10.28063639 27440 haloacid dehalogenase like hydrolase domain containing 5 "GO:0005739,GO:0046474" mitochondrion|glycerophospholipid biosynthetic process HDLBP 11002.9137 13739.45894 8266.368455 0.601651673 -0.732999617 0.031536493 0.795035182 94.04718551 59.02104048 3069 high density lipoprotein binding protein "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0005886,GO:0006869,GO:0008203,GO:0008289,GO:0034364,GO:0034384,GO:0045296" RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|polysome|plasma membrane|lipid transport|cholesterol metabolic process|lipid binding|high-density lipoprotein particle|high-density lipoprotein particle clearance|cadherin binding HDX 122.1025181 129.914364 114.2906723 0.879738536 -0.184853286 0.780488248 1 1.011017859 0.927744467 139324 highly divergent homeobox "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II" HEATR1 2444.979186 2562.76382 2327.194552 0.908079993 -0.139108704 0.663566636 1 15.34400598 14.53378717 55127 HEAT repeat containing 1 "GO:0000462,GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0006364,GO:0016020,GO:0030515,GO:0030686,GO:0032040,GO:0034455,GO:0045943,GO:2000234" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|fibrillar center|RNA binding|protein binding|nucleoplasm|nucleolus|mitochondrion|rRNA processing|membrane|snoRNA binding|90S preribosome|small-subunit processome|t-UTP complex|positive regulation of transcription by RNA polymerase I|positive regulation of rRNA processing" hsa03008 Ribosome biogenesis in eukaryotes HEATR3 287.5809189 328.8457338 246.3161041 0.749032385 -0.416899999 0.385350473 1 3.50407665 2.737726894 55027 HEAT repeat containing 3 "GO:0006606,GO:0042273,GO:0051082" protein import into nucleus|ribosomal large subunit biogenesis|unfolded protein binding HEATR4 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.059440263 0.024074775 399671 HEAT repeat containing 4 "GO:0008612,GO:0016491,GO:0018215,GO:0019135,GO:0055114" peptidyl-lysine modification to peptidyl-hypusine|oxidoreductase activity|protein phosphopantetheinylation|deoxyhypusine monooxygenase activity|oxidation-reduction process HEATR5A 738.5415411 780.5011397 696.5819425 0.892480366 -0.164107664 0.662206227 1 5.060764215 4.711190915 25938 HEAT repeat containing 5A "GO:0005829,GO:0006897,GO:0008104,GO:0030139,GO:0042147" "cytosol|endocytosis|protein localization|endocytic vesicle|retrograde transport, endosome to Golgi" HEATR5B 898.2798237 890.1163843 906.4432632 1.018342409 0.026222737 0.945068843 1 6.129334428 6.510630946 54497 HEAT repeat containing 5B "GO:0005515,GO:0005829,GO:0006897,GO:0008104,GO:0016020,GO:0030139,GO:0042147" "protein binding|cytosol|endocytosis|protein localization|membrane|endocytic vesicle|retrograde transport, endosome to Golgi" HEATR6 979.3684214 910.4155036 1048.321339 1.151475711 0.203483979 0.566048361 1 7.549006795 9.066935525 63897 HEAT repeat containing 6 GO:0003723 RNA binding HEBP1 969.4915289 841.3984978 1097.58456 1.304476491 0.383470945 0.279271533 1 36.76778743 50.02875355 50865 heme binding protein 1 "GO:0005576,GO:0005737,GO:0007186,GO:0007623,GO:0020037,GO:0070062" extracellular region|cytoplasm|G protein-coupled receptor signaling pathway|circadian rhythm|heme binding|extracellular exosome HEBP2 1017.619544 1033.225176 1002.013912 0.969792389 -0.044252163 0.902471001 1 5.201710751 5.261879522 23593 heme binding protein 2 "GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0010917,GO:0010940,GO:0020037,GO:0035578,GO:0035794,GO:0043312,GO:0070062,GO:1901031" protein binding|extracellular region|cytoplasm|mitochondrion|negative regulation of mitochondrial membrane potential|positive regulation of necrotic cell death|heme binding|azurophil granule lumen|positive regulation of mitochondrial membrane permeability|neutrophil degranulation|extracellular exosome|regulation of response to reactive oxygen species HECA 695.9391226 562.2856065 829.5926387 1.475393695 0.561099976 0.138191112 1 5.043886352 7.762277159 51696 "hdc homolog, cell cycle regulator" "GO:0003674,GO:0005634,GO:0005737,GO:0016020,GO:0030323,GO:0045930" molecular_function|nucleus|cytoplasm|membrane|respiratory tube development|negative regulation of mitotic cell cycle HECTD1 3642.074714 3674.140606 3610.008822 0.982545093 -0.025404475 0.937241592 1 20.17370556 20.67540848 25831 HECT domain E3 ubiquitin protein ligase 1 "GO:0003170,GO:0003281,GO:0005515,GO:0032436,GO:0035904,GO:0046872,GO:0048856,GO:0061630,GO:0070534" heart valve development|ventricular septum development|protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|aorta development|metal ion binding|anatomical structure development|ubiquitin protein ligase activity|protein K63-linked ubiquitination HECTD2 649.4035652 614.0483609 684.7587695 1.115154462 0.157243554 0.684441399 1 5.697944897 6.627797046 143279 HECT domain E3 ubiquitin protein ligase 2 "GO:0000209,GO:0004842,GO:0005829" protein polyubiquitination|ubiquitin-protein transferase activity|cytosol HECTD3 1431.920263 1437.177651 1426.662875 0.992683733 -0.010593944 0.976977164 1 20.23012173 20.94716872 79654 HECT domain E3 ubiquitin protein ligase 3 "GO:0004842,GO:0005515,GO:0016567,GO:0019905,GO:0043161,GO:0048471" ubiquitin-protein transferase activity|protein binding|protein ubiquitination|syntaxin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|perinuclear region of cytoplasm HECTD4 2833.83054 2742.411027 2925.250053 1.066670905 0.093115137 0.770612231 1 8.800750466 9.791880088 283450 HECT domain E3 ubiquitin protein ligase 4 "GO:0004842,GO:0005515,GO:0006006,GO:0016021,GO:0016567,GO:0042593" ubiquitin-protein transferase activity|protein binding|glucose metabolic process|integral component of membrane|protein ubiquitination|glucose homeostasis HECW1 33.36265658 24.35894324 42.36636991 1.739253197 0.798467973 0.410510098 1 0.100948739 0.183138494 23072 "HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1" "GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0016567,GO:0043161,GO:0045732,GO:0048814,GO:0061630,GO:0090090,GO:2000650" protein polyubiquitination|protein binding|cytoplasm|cytosol|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|regulation of dendrite morphogenesis|ubiquitin protein ligase activity|negative regulation of canonical Wnt signaling pathway|negative regulation of sodium ion transmembrane transporter activity HECW2 158.2725102 144.1237475 172.4212729 1.196341865 0.258629711 0.662743711 1 0.56518462 0.705279996 57520 "HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2" "GO:0000209,GO:0005515,GO:0005737,GO:0016567,GO:0030071,GO:0043161,GO:0045732,GO:0048814,GO:0061630,GO:0072686,GO:2000650" protein polyubiquitination|protein binding|cytoplasm|protein ubiquitination|regulation of mitotic metaphase/anaphase transition|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|regulation of dendrite morphogenesis|ubiquitin protein ligase activity|mitotic spindle|negative regulation of sodium ion transmembrane transporter activity HEG1 1185.308727 1214.902294 1155.715161 0.951282392 -0.07205442 0.835514715 1 6.510476699 6.460084174 57493 heart development protein with EGF like domains 1 "GO:0001570,GO:0001701,GO:0001886,GO:0001945,GO:0003017,GO:0003209,GO:0003222,GO:0003281,GO:0005509,GO:0005515,GO:0005576,GO:0005911,GO:0007043,GO:0007507,GO:0009791,GO:0009897,GO:0016021,GO:0030324,GO:0035024,GO:0035264,GO:0048845,GO:0050878,GO:0055017,GO:0060039,GO:0090271,GO:1902414,GO:1905709,GO:2000299" vasculogenesis|in utero embryonic development|endothelial cell morphogenesis|lymph vessel development|lymph circulation|cardiac atrium morphogenesis|ventricular trabecula myocardium morphogenesis|ventricular septum development|calcium ion binding|protein binding|extracellular region|cell-cell junction|cell-cell junction assembly|heart development|post-embryonic development|external side of plasma membrane|integral component of membrane|lung development|negative regulation of Rho protein signal transduction|multicellular organism growth|venous blood vessel morphogenesis|regulation of body fluid levels|cardiac muscle tissue growth|pericardium development|positive regulation of fibroblast growth factor production|protein localization to cell junction|negative regulation of membrane permeability|negative regulation of Rho-dependent protein serine/threonine kinase activity HELB 67.73754752 84.24134538 51.23374966 0.608178198 -0.717433994 0.354056213 1 1.214151098 0.770228376 92797 DNA helicase B "GO:0000462,GO:0003723,GO:0005524,GO:0005622,GO:0005634,GO:0005662,GO:0005730,GO:0005737,GO:0006260,GO:0006269,GO:0006281,GO:0006974,GO:0017116,GO:0032508,GO:0035861,GO:0043139,GO:0044877,GO:1903775,GO:2000042" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|ATP binding|intracellular anatomical structure|nucleus|DNA replication factor A complex|nucleolus|cytoplasm|DNA replication|DNA replication, synthesis of RNA primer|DNA repair|cellular response to DNA damage stimulus|single-stranded DNA helicase activity|DNA duplex unwinding|site of double-strand break|5'-3' DNA helicase activity|protein-containing complex binding|regulation of DNA double-strand break processing|negative regulation of double-strand break repair via homologous recombination" HELLS 1767.345889 1770.083209 1764.60857 0.996907129 -0.004468984 0.99101839 1 11.66690136 12.13182557 3070 "helicase, lymphoid specific" "GO:0000775,GO:0003682,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005721,GO:0006306,GO:0006346,GO:0007049,GO:0007275,GO:0010216,GO:0031508,GO:0046651,GO:0051301" "chromosome, centromeric region|chromatin binding|helicase activity|protein binding|ATP binding|nucleus|pericentric heterochromatin|DNA methylation|DNA methylation-dependent heterochromatin assembly|cell cycle|multicellular organism development|maintenance of DNA methylation|pericentric heterochromatin assembly|lymphocyte proliferation|cell division" HELQ 181.8270599 171.5275587 192.1265612 1.120091504 0.163616596 0.776004812 1 1.765345607 2.062524776 113510 "helicase, POLQ like" "GO:0000724,GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0006364,GO:0032508,GO:1990518" double-strand break repair via homologous recombination|DNA binding|protein binding|ATP binding|nucleus|rRNA processing|DNA duplex unwinding|single-stranded 3'-5' DNA helicase activity HELZ 1558.71949 1820.831007 1296.607972 0.712096821 -0.489854682 0.137978619 1 6.509399803 4.834993819 9931 helicase with zinc finger "GO:0003723,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0016020,GO:0035194,GO:0043186,GO:0046872" RNA binding|helicase activity|protein binding|ATP binding|nucleus|cytosol|membrane|post-transcriptional gene silencing by RNA|P granule|metal ion binding HELZ2 2293.251434 2158.811345 2427.691522 1.124550104 0.169347941 0.596946764 1 10.89114242 12.7752138 85441 helicase with zinc finger 2 "GO:0000184,GO:0003677,GO:0003723,GO:0003724,GO:0004540,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0016020,GO:0019216,GO:0030374,GO:0045944,GO:0046872,GO:0090501" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|DNA binding|RNA binding|RNA helicase activity|ribonuclease activity|protein binding|ATP binding|nucleoplasm|cytoplasm|membrane|regulation of lipid metabolic process|nuclear receptor coactivator activity|positive regulation of transcription by RNA polymerase II|metal ion binding|RNA phosphodiester bond hydrolysis" HEMK1 606.9332748 606.9436691 606.9228806 0.999965749 -4.94E-05 1 1 1.714324671 1.788109578 51409 HemK methyltransferase family member 1 "GO:0003677,GO:0005515,GO:0005739,GO:0006306,GO:0006479,GO:0008170,GO:0008276,GO:0102559" DNA binding|protein binding|mitochondrion|DNA methylation|protein methylation|N-methyltransferase activity|protein methyltransferase activity|protein-(glutamine-N5) methyltransferase activity HENMT1 205.4679627 238.5146526 172.4212729 0.722895935 -0.468140116 0.382204015 1 6.341168359 4.78146517 113802 HEN methyltransferase 1 "GO:0001510,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0008171,GO:0008173,GO:0030422,GO:0034587,GO:0043186,GO:0046872,GO:0090486" RNA methylation|RNA binding|protein binding|nucleus|cytoplasm|O-methyltransferase activity|RNA methyltransferase activity|production of siRNA involved in RNA interference|piRNA metabolic process|P granule|metal ion binding|small RNA 2'-O-methyltransferase HERC1 1561.80246 1358.011086 1765.593834 1.300132122 0.37865824 0.251223226 1 4.450816716 6.035915186 8925 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 "GO:0004842,GO:0005085,GO:0005737,GO:0005794,GO:0005829,GO:0010507,GO:0016020,GO:0016567,GO:0021702,GO:0031175,GO:0050790,GO:0050885" ubiquitin-protein transferase activity|guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|negative regulation of autophagy|membrane|protein ubiquitination|cerebellar Purkinje cell differentiation|neuron projection development|regulation of catalytic activity|neuromuscular process controlling balance hsa04120 Ubiquitin mediated proteolysis HERC2 3328.549075 3154.48315 3502.615001 1.11036098 0.151028775 0.635237052 1 9.843711841 11.40089676 8924 HECT and RLD domain containing E3 ubiquitin protein ligase 2 "GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005814,GO:0005829,GO:0005886,GO:0006303,GO:0006886,GO:0006974,GO:0008270,GO:0016020,GO:0016567,GO:0031625,GO:0032183,GO:0050790,GO:0061630" guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|centriole|cytosol|plasma membrane|double-strand break repair via nonhomologous end joining|intracellular protein transport|cellular response to DNA damage stimulus|zinc ion binding|membrane|protein ubiquitination|ubiquitin protein ligase binding|SUMO binding|regulation of catalytic activity|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis HERC3 452.4318378 350.1598091 554.7038665 1.584144874 0.663704279 0.113861446 1 1.544535712 2.552165186 8916 HECT and RLD domain containing E3 ubiquitin protein ligase 3 "GO:0004842,GO:0005829,GO:0016567,GO:0031410" ubiquitin-protein transferase activity|cytosol|protein ubiquitination|cytoplasmic vesicle hsa04120 Ubiquitin mediated proteolysis HERC4 1810.005216 1655.393184 1964.617247 1.186797955 0.247074346 0.447185901 1 9.934805654 12.29849857 26091 HECT and RLD domain containing E3 ubiquitin protein ligase 4 "GO:0001650,GO:0004842,GO:0005829,GO:0007283,GO:0016567,GO:0030154,GO:0045879" fibrillar center|ubiquitin-protein transferase activity|cytosol|spermatogenesis|protein ubiquitination|cell differentiation|negative regulation of smoothened signaling pathway hsa04120 Ubiquitin mediated proteolysis HERC5 313.3610973 340.0102494 286.7119452 0.843245007 -0.245976224 0.600960597 1 4.277277608 3.762159001 51191 HECT and RLD domain containing E3 ubiquitin protein ligase 5 "GO:0000079,GO:0000209,GO:0003723,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0016567,GO:0018215,GO:0032020,GO:0032480,GO:0042296,GO:0045087,GO:0048471,GO:0050688,GO:0051607,GO:0061630" regulation of cyclin-dependent protein serine/threonine kinase activity|protein polyubiquitination|RNA binding|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|protein ubiquitination|protein phosphopantetheinylation|ISG15-protein conjugation|negative regulation of type I interferon production|ISG15 transferase activity|innate immune response|perinuclear region of cytoplasm|regulation of defense response to virus|defense response to virus|ubiquitin protein ligase activity HERC6 230.3992103 225.320225 235.4781956 1.045082374 0.06361666 0.910044611 1 2.730718955 2.976757508 55008 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 "GO:0000209,GO:0004842,GO:0005654,GO:0005829" protein polyubiquitination|ubiquitin-protein transferase activity|nucleoplasm|cytosol HERPUD1 641.053066 683.0653667 599.0407653 0.87698893 -0.189369462 0.624747421 1 12.12578027 11.0922522 9709 homocysteine inducible ER protein with ubiquitin like domain 1 "GO:0003674,GO:0005515,GO:0005783,GO:0005789,GO:0006511,GO:0006986,GO:0016020,GO:0016021,GO:0016567,GO:0030433,GO:0030968,GO:0030970,GO:0031396,GO:0032469,GO:0034976,GO:0036499,GO:0043154,GO:0044322,GO:0044325,GO:0045047,GO:1902236,GO:1903069,GO:1903071,GO:1990037,GO:1990756,GO:2001243" "molecular_function|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|ubiquitin-dependent protein catabolic process|response to unfolded protein|membrane|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|regulation of protein ubiquitination|endoplasmic reticulum calcium ion homeostasis|response to endoplasmic reticulum stress|PERK-mediated unfolded protein response|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|endoplasmic reticulum quality control compartment|ion channel binding|protein targeting to ER|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|Lewy body core|ubiquitin ligase-substrate adaptor activity|negative regulation of intrinsic apoptotic signaling pathway" hsa04141 Protein processing in endoplasmic reticulum HERPUD2 666.6808272 549.0911789 784.2704756 1.428306456 0.514305555 0.178120483 1 7.827056328 11.66099981 64224 HERPUD family member 2 "GO:0005515,GO:0007283,GO:0016021,GO:0030968" protein binding|spermatogenesis|integral component of membrane|endoplasmic reticulum unfolded protein response HES1 241.7864126 262.8735958 220.6992293 0.839564083 -0.252287647 0.622465491 1 8.453092232 7.402618838 3280 hes family bHLH transcription factor 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001085,GO:0001227,GO:0001889,GO:0003143,GO:0003151,GO:0003266,GO:0003281,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007155,GO:0007219,GO:0007224,GO:0007399,GO:0008134,GO:0008284,GO:0009952,GO:0016477,GO:0021537,GO:0021555,GO:0021557,GO:0021558,GO:0021575,GO:0021861,GO:0021984,GO:0030324,GO:0030513,GO:0030901,GO:0031016,GO:0032991,GO:0035019,GO:0035910,GO:0042102,GO:0042531,GO:0042803,GO:0042826,GO:0043388,GO:0043398,GO:0043433,GO:0043565,GO:0045598,GO:0045608,GO:0045665,GO:0045747,GO:0045892,GO:0045893,GO:0045944,GO:0045977,GO:0046331,GO:0046425,GO:0046427,GO:0048469,GO:0048538,GO:0048667,GO:0048711,GO:0048715,GO:0048844,GO:0050678,GO:0050767,GO:0051087,GO:0060122,GO:0060164,GO:0060253,GO:0060412,GO:0060675,GO:0060716,GO:0061009,GO:0061106,GO:0061309,GO:0061626,GO:0065003,GO:0070888,GO:0071820,GO:0072012,GO:0072049,GO:0072050,GO:0072141,GO:0072282,GO:0090102,GO:0090162,GO:0097084,GO:0097150,GO:1905934,GO:1990837,GO:2000227,GO:2000737,GO:2000974,GO:2000978" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|liver development|embryonic heart tube morphogenesis|outflow tract morphogenesis|regulation of secondary heart field cardioblast proliferation|ventricular septum development|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|cell adhesion|Notch signaling pathway|smoothened signaling pathway|nervous system development|transcription factor binding|positive regulation of cell population proliferation|anterior/posterior pattern specification|cell migration|telencephalon development|midbrain-hindbrain boundary morphogenesis|oculomotor nerve development|trochlear nerve development|hindbrain morphogenesis|forebrain radial glial cell differentiation|adenohypophysis development|lung development|positive regulation of BMP signaling pathway|midbrain development|pancreas development|protein-containing complex|somatic stem cell population maintenance|ascending aorta morphogenesis|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|histone deacetylase binding|positive regulation of DNA binding|HLH domain binding|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|regulation of fat cell differentiation|negative regulation of inner ear auditory receptor cell differentiation|negative regulation of neuron differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of mitotic cell cycle, embryonic|lateral inhibition|regulation of receptor signaling pathway via JAK-STAT|positive regulation of receptor signaling pathway via JAK-STAT|cell maturation|thymus development|cell morphogenesis involved in neuron differentiation|positive regulation of astrocyte differentiation|negative regulation of oligodendrocyte differentiation|artery morphogenesis|regulation of epithelial cell proliferation|regulation of neurogenesis|chaperone binding|inner ear receptor cell stereocilium organization|regulation of timing of neuron differentiation|negative regulation of glial cell proliferation|ventricular septum morphogenesis|ureteric bud morphogenesis|labyrinthine layer blood vessel development|common bile duct development|negative regulation of stomach neuroendocrine cell differentiation|cardiac neural crest cell development involved in outflow tract morphogenesis|pharyngeal arch artery morphogenesis|protein-containing complex assembly|E-box binding|N-box binding|glomerulus vasculature development|comma-shaped body morphogenesis|S-shaped body morphogenesis|renal interstitial fibroblast development|metanephric nephron tubule morphogenesis|cochlea development|establishment of epithelial cell polarity|vascular associated smooth muscle cell development|neuronal stem cell population maintenance|negative regulation of cell fate determination|sequence-specific double-stranded DNA binding|negative regulation of pancreatic A cell differentiation|negative regulation of stem cell differentiation|negative regulation of pro-B cell differentiation|negative regulation of forebrain neuron differentiation" "hsa03460,hsa04330,hsa04950,hsa05165,hsa05169,hsa05200,hsa05224" Fanconi anemia pathway|Notch signaling pathway|Maturity onset diabetes of the young|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Breast cancer bHLH HES2 4.44853565 1.014955968 7.882115332 7.765967764 2.957165719 0.193307679 1 0.01206099 0.097699979 54626 hes family bHLH transcription factor 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0008134,GO:0009952,GO:0046983,GO:0050767,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|transcription factor binding|anterior/posterior pattern specification|protein dimerization activity|regulation of neurogenesis|sequence-specific double-stranded DNA binding" hsa05165 Human papillomavirus infection HES4 219.012008 187.7668541 250.2571618 1.332807981 0.414468945 0.430137368 1 9.854641203 13.70011874 57801 hes family bHLH transcription factor 4 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0007399,GO:0008134,GO:0009952,GO:0030154,GO:0046983" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|nervous system development|transcription factor binding|anterior/posterior pattern specification|cell differentiation|protein dimerization activity" hsa05165 Human papillomavirus infection bHLH HES6 41.8710161 33.49354696 50.24848524 1.500243773 0.585196941 0.52214853 1 1.240007306 1.940447989 55502 hes family bHLH transcription factor 6 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0006355,GO:0006357,GO:0008134,GO:0009952,GO:0043433,GO:0046983,GO:0050767,GO:0061629,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription factor binding|anterior/posterior pattern specification|negative regulation of DNA-binding transcription factor activity|protein dimerization activity|regulation of neurogenesis|RNA polymerase II-specific DNA-binding transcription factor binding|sequence-specific double-stranded DNA binding" hsa05165 Human papillomavirus infection HES7 29.70366865 43.64310664 15.76423066 0.361207803 -1.469099036 0.142075485 1 0.836944107 0.315333063 84667 hes family bHLH transcription factor 7 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001501,GO:0001756,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007219,GO:0007498,GO:0008134,GO:0009952,GO:0036342,GO:0046983,GO:0048511,GO:0050767,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|skeletal system development|somitogenesis|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|Notch signaling pathway|mesoderm development|transcription factor binding|anterior/posterior pattern specification|post-anal tail morphogenesis|protein dimerization activity|rhythmic process|regulation of neurogenesis|sequence-specific double-stranded DNA binding" hsa05165 Human papillomavirus infection HESX1 26.52518876 28.41876711 24.63161041 0.866737474 -0.206333014 0.87428341 1 0.721458796 0.652251425 8820 HESX homeobox 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0008022,GO:0008406,GO:0010467,GO:0021983,GO:0030878,GO:0030916,GO:0035264,GO:0043010,GO:0043584,GO:0045995,GO:0047485,GO:0048853,GO:0048861,GO:0048863,GO:0060070,GO:0070371,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|chromatin binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|protein C-terminus binding|gonad development|gene expression|pituitary gland development|thyroid gland development|otic vesicle formation|multicellular organism growth|camera-type eye development|nose development|regulation of embryonic development|protein N-terminus binding|forebrain morphogenesis|leukemia inhibitory factor signaling pathway|stem cell differentiation|canonical Wnt signaling pathway|ERK1 and ERK2 cascade|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells HEXA 4452.383935 4544.972826 4359.795043 0.95925657 -0.060011354 0.85162303 1 47.77643004 47.80401866 3073 hexosaminidase subunit alpha "GO:0004563,GO:0005515,GO:0005829,GO:0005975,GO:0006024,GO:0006687,GO:0006689,GO:0008375,GO:0016020,GO:0030207,GO:0030214,GO:0042340,GO:0042582,GO:0043202,GO:0043231,GO:0046982,GO:0070062,GO:0102148" beta-N-acetylhexosaminidase activity|protein binding|cytosol|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|glycosphingolipid metabolic process|ganglioside catabolic process|acetylglucosaminyltransferase activity|membrane|chondroitin sulfate catabolic process|hyaluronan catabolic process|keratan sulfate catabolic process|azurophil granule|lysosomal lumen|intracellular membrane-bounded organelle|protein heterodimerization activity|extracellular exosome|N-acetyl-beta-D-galactosaminidase activity "hsa00511,hsa00513,hsa00520,hsa00531,hsa00603,hsa00604,hsa04142" Other glycan degradation|Various types of N-glycan biosynthesis|Amino sugar and nucleotide sugar metabolism|Glycosaminoglycan degradation|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series|Lysosome HEXB 2061.496806 2447.05884 1675.934773 0.684877186 -0.546082791 0.089950755 1 52.78317612 37.70718823 3074 hexosaminidase subunit beta "GO:0001501,GO:0001669,GO:0004563,GO:0005515,GO:0005576,GO:0006687,GO:0006689,GO:0006874,GO:0007040,GO:0007341,GO:0007605,GO:0007626,GO:0008049,GO:0008360,GO:0008375,GO:0008654,GO:0009313,GO:0016020,GO:0019915,GO:0030207,GO:0030214,GO:0035578,GO:0042340,GO:0042552,GO:0042582,GO:0042802,GO:0043202,GO:0043312,GO:0043615,GO:0044267,GO:0045944,GO:0048477,GO:0050885,GO:0070062,GO:0102148" skeletal system development|acrosomal vesicle|beta-N-acetylhexosaminidase activity|protein binding|extracellular region|glycosphingolipid metabolic process|ganglioside catabolic process|cellular calcium ion homeostasis|lysosome organization|penetration of zona pellucida|sensory perception of sound|locomotory behavior|male courtship behavior|regulation of cell shape|acetylglucosaminyltransferase activity|phospholipid biosynthetic process|oligosaccharide catabolic process|membrane|lipid storage|chondroitin sulfate catabolic process|hyaluronan catabolic process|azurophil granule lumen|keratan sulfate catabolic process|myelination|azurophil granule|identical protein binding|lysosomal lumen|neutrophil degranulation|astrocyte cell migration|cellular protein metabolic process|positive regulation of transcription by RNA polymerase II|oogenesis|neuromuscular process controlling balance|extracellular exosome|N-acetyl-beta-D-galactosaminidase activity "hsa00511,hsa00513,hsa00520,hsa00531,hsa00603,hsa00604,hsa04142" Other glycan degradation|Various types of N-glycan biosynthesis|Amino sugar and nucleotide sugar metabolism|Glycosaminoglycan degradation|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series|Lysosome HEXD 141.4339405 138.0340117 144.8338692 1.049262189 0.069375222 0.920438253 1 2.466808658 2.69982377 284004 hexosaminidase D "GO:0004563,GO:0005634,GO:0005737,GO:0005975,GO:0015929,GO:0102148,GO:1903561" beta-N-acetylhexosaminidase activity|nucleus|cytoplasm|carbohydrate metabolic process|hexosaminidase activity|N-acetyl-beta-D-galactosaminidase activity|extracellular vesicle "hsa00511,hsa00513" Other glycan degradation|Various types of N-glycan biosynthesis HEXIM1 1421.627443 1710.200807 1133.054079 0.662526923 -0.593949011 0.075640076 1 23.893969 16.51230711 10614 HEXIM P-TEFb complex subunit 1 "GO:0000122,GO:0002218,GO:0004860,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007507,GO:0017069,GO:0032897,GO:0034244,GO:0042802,GO:0043231,GO:0045087,GO:0045736,GO:0045892,GO:0097322,GO:0106140,GO:0120259,GO:1901798" "negative regulation of transcription by RNA polymerase II|activation of innate immune response|protein kinase inhibitor activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|heart development|snRNA binding|negative regulation of viral transcription|negative regulation of transcription elongation from RNA polymerase II promoter|identical protein binding|intracellular membrane-bounded organelle|innate immune response|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|7SK snRNA binding|P-TEFb complex binding|7SK snRNP|positive regulation of signal transduction by p53 class mediator" other HEXIM2 194.1846809 208.0659735 180.3033882 0.866568354 -0.206614542 0.710147061 1 4.06551217 3.674802646 124790 HEXIM P-TEFb complex subunit 2 "GO:0000122,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016607,GO:0017069,GO:0042802,GO:0045736,GO:0045892,GO:0097322" "negative regulation of transcription by RNA polymerase II|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|nuclear speck|snRNA binding|identical protein binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|7SK snRNA binding" HEY1 72.42361558 101.4955968 43.35163433 0.427128227 -1.227258852 0.105615064 1 2.071069269 0.922717648 23462 hes related family bHLH transcription factor with YRPW motif 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001525,GO:0003184,GO:0003190,GO:0003203,GO:0003208,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007219,GO:0008134,GO:0009952,GO:0010628,GO:0035912,GO:0036304,GO:0045665,GO:0045746,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0050767,GO:0060317,GO:0060347,GO:0060411,GO:0060412,GO:0060716,GO:0060842,GO:0061314,GO:0070168,GO:0071385,GO:0072359,GO:1990837,GO:2000678,GO:2000820,GO:2001212" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|angiogenesis|pulmonary valve morphogenesis|atrioventricular valve formation|endocardial cushion morphogenesis|cardiac ventricle morphogenesis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|Notch signaling pathway|transcription factor binding|anterior/posterior pattern specification|positive regulation of gene expression|dorsal aorta morphogenesis|umbilical cord morphogenesis|negative regulation of neuron differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of neurogenesis|cardiac epithelial to mesenchymal transition|heart trabecula formation|cardiac septum morphogenesis|ventricular septum morphogenesis|labyrinthine layer blood vessel development|arterial endothelial cell differentiation|Notch signaling involved in heart development|negative regulation of biomineral tissue development|cellular response to glucocorticoid stimulus|circulatory system development|sequence-specific double-stranded DNA binding|negative regulation of transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|regulation of vasculogenesis" "hsa04330,hsa05165,hsa05200,hsa05224" Notch signaling pathway|Human papillomavirus infection|Pathways in cancer|Breast cancer bHLH HFE 188.6321146 198.9313698 178.3328594 0.896454187 -0.157698238 0.781399428 1 1.946517019 1.820129276 3077 homeostatic iron regulator "GO:0002474,GO:0002626,GO:0002725,GO:0005102,GO:0005515,GO:0005615,GO:0005654,GO:0005769,GO:0005886,GO:0005887,GO:0006879,GO:0006953,GO:0007565,GO:0009897,GO:0010039,GO:0010106,GO:0010628,GO:0010862,GO:0019882,GO:0030509,GO:0030881,GO:0031410,GO:0032092,GO:0032435,GO:0033572,GO:0034756,GO:0039706,GO:0042605,GO:0042612,GO:0045177,GO:0045178,GO:0048260,GO:0048471,GO:0055037,GO:0055072,GO:0065003,GO:0071281,GO:0090277,GO:0097421,GO:0098711,GO:1900121,GO:1900122,GO:1904283,GO:1904434,GO:1904437,GO:1990357,GO:1990459,GO:1990641,GO:1990712,GO:2000008,GO:2000059,GO:2000272,GO:2000273,GO:2001186" "antigen processing and presentation of peptide antigen via MHC class I|negative regulation of T cell antigen processing and presentation|negative regulation of T cell cytokine production|signaling receptor binding|protein binding|extracellular space|nucleoplasm|early endosome|plasma membrane|integral component of plasma membrane|cellular iron ion homeostasis|acute-phase response|female pregnancy|external side of plasma membrane|response to iron ion|cellular response to iron ion starvation|positive regulation of gene expression|positive regulation of pathway-restricted SMAD protein phosphorylation|antigen processing and presentation|BMP signaling pathway|beta-2-microglobulin binding|cytoplasmic vesicle|positive regulation of protein binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|transferrin transport|regulation of iron ion transport|co-receptor binding|peptide antigen binding|MHC class I protein complex|apical part of cell|basal part of cell|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|recycling endosome|iron ion homeostasis|protein-containing complex assembly|cellular response to iron ion|positive regulation of peptide hormone secretion|liver regeneration|iron ion import across plasma membrane|negative regulation of receptor binding|positive regulation of receptor binding|negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I|positive regulation of ferrous iron binding|positive regulation of transferrin receptor binding|terminal web|transferrin receptor binding|response to iron ion starvation|HFE-transferrin receptor complex|regulation of protein localization to cell surface|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of signaling receptor activity|positive regulation of signaling receptor activity|negative regulation of CD8-positive, alpha-beta T cell activation" HFM1 9.971410373 8.119647747 11.823173 1.456118956 0.542128219 0.750122204 1 0.076550915 0.116268795 164045 helicase for meiosis 1 "GO:0000712,GO:0003678,GO:0003729,GO:0005524,GO:0006417,GO:0010494,GO:0032508" resolution of meiotic recombination intermediates|DNA helicase activity|mRNA binding|ATP binding|regulation of translation|cytoplasmic stress granule|DNA duplex unwinding HGD 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.081723274 0.062062397 3081 "homogentisate 1,2-dioxygenase" "GO:0004411,GO:0005515,GO:0005737,GO:0005829,GO:0006559,GO:0006572,GO:0042802,GO:0046872,GO:0055114,GO:0070062" "homogentisate 1,2-dioxygenase activity|protein binding|cytoplasm|cytosol|L-phenylalanine catabolic process|tyrosine catabolic process|identical protein binding|metal ion binding|oxidation-reduction process|extracellular exosome" hsa00350 Tyrosine metabolism HGH1 853.0588594 930.714623 775.4030958 0.833126585 -0.263392379 0.468460095 1 18.60197802 16.1653849 51236 HGH1 homolog "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process HGS 2589.622782 2516.075846 2663.169718 1.058461621 0.081968959 0.797955025 1 44.04782765 48.63126201 9146 hepatocyte growth factor-regulated tyrosine kinase substrate "GO:0005515,GO:0005764,GO:0005768,GO:0005769,GO:0005829,GO:0006622,GO:0007165,GO:0008285,GO:0010324,GO:0010628,GO:0010642,GO:0016197,GO:0016236,GO:0016525,GO:0016579,GO:0019904,GO:0030948,GO:0031901,GO:0032585,GO:0033565,GO:0036258,GO:0042059,GO:0042176,GO:0043231,GO:0043405,GO:0044389,GO:0046426,GO:0046872,GO:0061024,GO:0070062,GO:0072657,GO:1903543" protein binding|lysosome|endosome|early endosome|cytosol|protein targeting to lysosome|signal transduction|negative regulation of cell population proliferation|membrane invagination|positive regulation of gene expression|negative regulation of platelet-derived growth factor receptor signaling pathway|endosomal transport|macroautophagy|negative regulation of angiogenesis|protein deubiquitination|protein domain specific binding|negative regulation of vascular endothelial growth factor receptor signaling pathway|early endosome membrane|multivesicular body membrane|ESCRT-0 complex|multivesicular body assembly|negative regulation of epidermal growth factor receptor signaling pathway|regulation of protein catabolic process|intracellular membrane-bounded organelle|regulation of MAP kinase activity|ubiquitin-like protein ligase binding|negative regulation of receptor signaling pathway via JAK-STAT|metal ion binding|membrane organization|extracellular exosome|protein localization to membrane|positive regulation of exosomal secretion "hsa04144,hsa04145" Endocytosis|Phagosome HGSNAT 1215.563174 1094.122534 1337.003813 1.221987275 0.289229261 0.397145653 1 10.000622 12.74704812 138050 heparan-alpha-glucosaminide N-acetyltransferase "GO:0005765,GO:0005886,GO:0006027,GO:0007041,GO:0015019,GO:0016021,GO:0016746,GO:0035579,GO:0043312,GO:0051259,GO:0070821" "lysosomal membrane|plasma membrane|glycosaminoglycan catabolic process|lysosomal transport|heparan-alpha-glucosaminide N-acetyltransferase activity|integral component of membrane|transferase activity, transferring acyl groups|specific granule membrane|neutrophil degranulation|protein complex oligomerization|tertiary granule membrane" "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome HHAT 99.28085462 85.25630134 113.3054079 1.32899746 0.410338347 0.551378775 1 0.988537293 1.370355157 55733 hedgehog acyltransferase "GO:0005515,GO:0005525,GO:0005783,GO:0005789,GO:0007224,GO:0007275,GO:0008374,GO:0016021,GO:0016409,GO:0016746,GO:0018345" "protein binding|GTP binding|endoplasmic reticulum|endoplasmic reticulum membrane|smoothened signaling pathway|multicellular organism development|O-acyltransferase activity|integral component of membrane|palmitoyltransferase activity|transferase activity, transferring acyl groups|protein palmitoylation" HHEX 433.9087683 498.3433805 369.4741562 0.741404764 -0.43166671 0.308976663 1 14.63998502 11.32170759 3087 hematopoietically expressed homeobox "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0006406,GO:0008134,GO:0008190,GO:0008301,GO:0009611,GO:0009952,GO:0010621,GO:0010944,GO:0016055,GO:0016525,GO:0016973,GO:0017025,GO:0030154,GO:0030177,GO:0030183,GO:0030948,GO:0032993,GO:0034504,GO:0042803,GO:0043434,GO:0043565,GO:0045736,GO:0045892,GO:0045893,GO:0045944,GO:0070491,GO:0070663,GO:0071103,GO:0090263" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|mRNA export from nucleus|transcription factor binding|eukaryotic initiation factor 4E binding|DNA binding, bending|response to wounding|anterior/posterior pattern specification|negative regulation of transcription by transcription factor localization|negative regulation of transcription by competitive promoter binding|Wnt signaling pathway|negative regulation of angiogenesis|poly(A)+ mRNA export from nucleus|TBP-class protein binding|cell differentiation|positive regulation of Wnt signaling pathway|B cell differentiation|negative regulation of vascular endothelial growth factor receptor signaling pathway|protein-DNA complex|protein localization to nucleus|protein homodimerization activity|response to peptide hormone|sequence-specific DNA binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|repressing transcription factor binding|regulation of leukocyte proliferation|DNA conformation change|positive regulation of canonical Wnt signaling pathway" "hsa04950,hsa05202" Maturity onset diabetes of the young|Transcriptional misregulation in cancer HHIPL1 7.47855778 6.08973581 8.867379749 1.456118956 0.542128219 0.797747104 1 0.033788742 0.051319782 84439 HHIP like 1 "GO:0003674,GO:0003824,GO:0005044,GO:0005575,GO:0005576,GO:0006897,GO:0008150,GO:0016020" molecular_function|catalytic activity|scavenger receptor activity|cellular_component|extracellular region|endocytosis|biological_process|membrane HHIPL2 16.01660886 17.25425146 14.77896625 0.856540562 -0.223406527 0.902492563 1 0.259770204 0.232088275 79802 HHIP like 2 "GO:0003824,GO:0005515,GO:0005576" catalytic activity|protein binding|extracellular region HIBADH 1714.322482 1748.769134 1679.87583 0.960604689 -0.057985244 0.860616522 1 44.7996901 44.88855671 11112 3-hydroxyisobutyrate dehydrogenase "GO:0005515,GO:0005739,GO:0005759,GO:0006574,GO:0008442,GO:0009083,GO:0016616,GO:0050661,GO:0051287,GO:0055114" "protein binding|mitochondrion|mitochondrial matrix|valine catabolic process|3-hydroxyisobutyrate dehydrogenase activity|branched-chain amino acid catabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|NADP binding|NAD binding|oxidation-reduction process" hsa00280 "Valine, leucine and isoleucine degradation" HIBCH 289.2221191 340.0102494 238.4339888 0.701255298 -0.511988329 0.284941557 1 6.742490074 4.931878863 26275 3-hydroxyisobutyryl-CoA hydrolase "GO:0003860,GO:0005739,GO:0005759,GO:0006574,GO:0009083" 3-hydroxyisobutyryl-CoA hydrolase activity|mitochondrion|mitochondrial matrix|valine catabolic process|branched-chain amino acid catabolic process "hsa00280,hsa00410,hsa00640" "Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Propanoate metabolism" HIC1 291.5746787 231.4099608 351.7393967 1.519983822 0.604055969 0.205931246 1 3.674011959 5.824993713 3090 HIC ZBTB transcriptional repressor 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0007275,GO:0008630,GO:0016055,GO:0030178,GO:0042826,GO:0043517,GO:0043565,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|intrinsic apoptotic signaling pathway in response to DNA damage|Wnt signaling pathway|negative regulation of Wnt signaling pathway|histone deacetylase binding|positive regulation of DNA damage response, signal transduction by p53 class mediator|sequence-specific DNA binding|metal ion binding|sequence-specific double-stranded DNA binding" HIC2 343.7112991 326.8158218 360.6067765 1.103394488 0.141948679 0.758846852 1 1.846092844 2.124713018 23119 HIC ZBTB transcriptional repressor 2 "GO:0000122,GO:0000978,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008022,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|protein C-terminus binding|negative regulation of transcription, DNA-templated|metal ion binding" HID1 226.0397493 230.3950048 221.6844937 0.962193143 -0.055601577 0.923210134 1 3.538112253 3.550992824 283987 HID1 domain containing "GO:0000138,GO:0005515,GO:0005737,GO:0005794,GO:0005797,GO:0005829,GO:0005881,GO:0016020,GO:0070062,GO:0090498" Golgi trans cisterna|protein binding|cytoplasm|Golgi apparatus|Golgi medial cisterna|cytosol|cytoplasmic microtubule|membrane|extracellular exosome|extrinsic component of Golgi membrane HIF1A 7478.740142 7887.22283 7070.257453 0.896419133 -0.157754653 0.631686255 1 95.29103337 89.1002831 3091 hypoxia inducible factor 1 subunit alpha "GO:0000302,GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0001525,GO:0001666,GO:0001755,GO:0001837,GO:0001892,GO:0001922,GO:0001938,GO:0001947,GO:0002039,GO:0002052,GO:0002248,GO:0002534,GO:0003151,GO:0003208,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006089,GO:0006110,GO:0006355,GO:0006357,GO:0006879,GO:0007165,GO:0007595,GO:0008134,GO:0008542,GO:0010039,GO:0010468,GO:0010573,GO:0010575,GO:0010628,GO:0010629,GO:0010634,GO:0014850,GO:0016239,GO:0016567,GO:0016579,GO:0016604,GO:0016607,GO:0019221,GO:0019896,GO:0019899,GO:0019901,GO:0019904,GO:0021502,GO:0021987,GO:0030502,GO:0030949,GO:0031514,GO:0031625,GO:0032007,GO:0032364,GO:0032722,GO:0032909,GO:0032963,GO:0032991,GO:0035035,GO:0035162,GO:0035257,GO:0035774,GO:0042541,GO:0042593,GO:0042826,GO:0043536,GO:0043565,GO:0043619,GO:0043687,GO:0045648,GO:0045766,GO:0045821,GO:0045893,GO:0045926,GO:0045944,GO:0046716,GO:0046886,GO:0046982,GO:0048546,GO:0051000,GO:0051216,GO:0051541,GO:0051879,GO:0060574,GO:0061030,GO:0061072,GO:0061298,GO:0061418,GO:0061419,GO:0070101,GO:0070244,GO:0070888,GO:0071347,GO:0071456,GO:0071542,GO:0090575,GO:0097411,GO:0098586,GO:1902895,GO:1903377,GO:1903599,GO:1903715,GO:1904115,GO:2000273,GO:2000378,GO:2000434,GO:2001054" "response to reactive oxygen species|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|response to hypoxia|neural crest cell migration|epithelial to mesenchymal transition|embryonic placenta development|B-1 B cell homeostasis|positive regulation of endothelial cell proliferation|heart looping|p53 binding|positive regulation of neuroblast proliferation|connective tissue replacement involved in inflammatory response wound healing|cytokine production involved in inflammatory response|outflow tract morphogenesis|cardiac ventricle morphogenesis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|lactate metabolic process|regulation of glycolytic process|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cellular iron ion homeostasis|signal transduction|lactation|transcription factor binding|visual learning|response to iron ion|regulation of gene expression|vascular endothelial growth factor production|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|negative regulation of gene expression|positive regulation of epithelial cell migration|response to muscle activity|positive regulation of macroautophagy|protein ubiquitination|protein deubiquitination|nuclear body|nuclear speck|cytokine-mediated signaling pathway|axonal transport of mitochondrion|enzyme binding|protein kinase binding|protein domain specific binding|neural fold elevation formation|cerebral cortex development|negative regulation of bone mineralization|positive regulation of vascular endothelial growth factor receptor signaling pathway|motile cilium|ubiquitin protein ligase binding|negative regulation of TOR signaling|oxygen homeostasis|positive regulation of chemokine production|regulation of transforming growth factor beta2 production|collagen metabolic process|protein-containing complex|histone acetyltransferase binding|embryonic hemopoiesis|nuclear hormone receptor binding|positive regulation of insulin secretion involved in cellular response to glucose stimulus|hemoglobin biosynthetic process|glucose homeostasis|histone deacetylase binding|positive regulation of blood vessel endothelial cell migration|sequence-specific DNA binding|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|post-translational protein modification|positive regulation of erythrocyte differentiation|positive regulation of angiogenesis|positive regulation of glycolytic process|positive regulation of transcription, DNA-templated|negative regulation of growth|positive regulation of transcription by RNA polymerase II|muscle cell cellular homeostasis|positive regulation of hormone biosynthetic process|protein heterodimerization activity|digestive tract morphogenesis|positive regulation of nitric-oxide synthase activity|cartilage development|elastin metabolic process|Hsp90 protein binding|intestinal epithelial cell maturation|epithelial cell differentiation involved in mammary gland alveolus development|iris morphogenesis|retina vasculature development in camera-type eye|regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of chemokine-mediated signaling pathway|negative regulation of thymocyte apoptotic process|E-box binding|cellular response to interleukin-1|cellular response to hypoxia|dopaminergic neuron differentiation|RNA polymerase II transcription regulator complex|hypoxia-inducible factor-1alpha signaling pathway|cellular response to virus|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|positive regulation of autophagy of mitochondrion|regulation of aerobic respiration|axon cytoplasm|positive regulation of signaling receptor activity|negative regulation of reactive oxygen species metabolic process|regulation of protein neddylation|negative regulation of mesenchymal cell apoptotic process" "hsa04066,hsa04137,hsa04140,hsa04659,hsa04919,hsa05167,hsa05200,hsa05205,hsa05211,hsa05230,hsa05231,hsa05235" HIF-1 signaling pathway|Mitophagy - animal|Autophagy - animal|Th17 cell differentiation|Thyroid hormone signaling pathway|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|Renal cell carcinoma|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer other HIF1AN 3716.012845 3508.702783 3923.322907 1.118169064 0.161138336 0.612973976 1 13.66003674 15.9321824 55662 hypoxia inducible factor 1 subunit alpha inhibitor "GO:0005112,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008198,GO:0008270,GO:0016706,GO:0018215,GO:0019826,GO:0031406,GO:0036138,GO:0036139,GO:0036140,GO:0042264,GO:0042265,GO:0042803,GO:0045663,GO:0045746,GO:0048471,GO:0051059,GO:0055114,GO:0061418,GO:0061428,GO:0071532,GO:0102113,GO:2001214" Notch binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ferrous iron binding|zinc ion binding|2-oxoglutarate-dependent dioxygenase activity|protein phosphopantetheinylation|oxygen sensor activity|carboxylic acid binding|peptidyl-histidine hydroxylation|peptidyl-histidine dioxygenase activity|peptidyl-asparagine 3-dioxygenase activity|peptidyl-aspartic acid hydroxylation|peptidyl-asparagine hydroxylation|protein homodimerization activity|positive regulation of myoblast differentiation|negative regulation of Notch signaling pathway|perinuclear region of cytoplasm|NF-kappaB binding|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|ankyrin repeat binding|hypoxia-inducible factor-asparagine oxygenase activity|positive regulation of vasculogenesis HIGD1A 3017.96686 2970.776119 3065.1576 1.031769974 0.045121368 0.888151748 1 50.38825525 54.22856791 25994 HIG1 hypoxia inducible domain family member 1A "GO:0005654,GO:0005739,GO:0005743,GO:0016021,GO:0032991,GO:0043066,GO:0055114,GO:0061418,GO:0070469,GO:0097250" nucleoplasm|mitochondrion|mitochondrial inner membrane|integral component of membrane|protein-containing complex|negative regulation of apoptotic process|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|respirasome|mitochondrial respirasome assembly HIGD2A 1023.42721 1026.120484 1020.733936 0.994750569 -0.007593275 0.985872505 1 79.46388774 82.45176086 192286 HIG1 hypoxia inducible domain family member 2A "GO:0005739,GO:0005743,GO:0016021,GO:0043066,GO:0055114,GO:0070469,GO:0097250" mitochondrion|mitochondrial inner membrane|integral component of membrane|negative regulation of apoptotic process|oxidation-reduction process|respirasome|mitochondrial respirasome assembly HIKESHI 633.3100058 625.2128765 641.4071352 1.025901992 0.036892911 0.928071366 1 18.62636857 19.93195945 51501 heat shock protein nuclear import factor hikeshi "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006606,GO:0007030,GO:0015031,GO:0016604,GO:0016607,GO:0030324,GO:0030544,GO:0034605,GO:0061608,GO:1900034" protein binding|nucleus|nucleoplasm|cytosol|protein import into nucleus|Golgi organization|protein transport|nuclear body|nuclear speck|lung development|Hsp70 protein binding|cellular response to heat|nuclear import signal receptor activity|regulation of cellular response to heat HILPDA 523.5109227 831.2489381 215.7729072 0.259576761 -1.945766863 3.26E-06 0.001028245 33.679861 9.119101081 29923 hypoxia inducible lipid droplet associated "GO:0001819,GO:0005102,GO:0005515,GO:0005615,GO:0005654,GO:0005811,GO:0005829,GO:0008284,GO:0009986,GO:0010884,GO:0016021,GO:0030141,GO:0034389,GO:0035425,GO:0071456" positive regulation of cytokine production|signaling receptor binding|protein binding|extracellular space|nucleoplasm|lipid droplet|cytosol|positive regulation of cell population proliferation|cell surface|positive regulation of lipid storage|integral component of membrane|secretory granule|lipid droplet organization|autocrine signaling|cellular response to hypoxia HINFP 644.064283 552.1360468 735.9925192 1.33299125 0.41466731 0.281300254 1 8.962738125 12.46189064 25988 histone H4 transcription factor "GO:0000077,GO:0000082,GO:0000083,GO:0000122,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001701,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006281,GO:0006351,GO:0006355,GO:0006357,GO:0010468,GO:0010628,GO:0010629,GO:0015030,GO:0019899,GO:0042393,GO:0045184,GO:0045445,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0048856" "DNA damage checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|Cajal body|enzyme binding|histone binding|establishment of protein localization|myoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|anatomical structure development" zf-C2H2 HINT1 4317.798349 4268.904803 4366.691894 1.022906833 0.03267475 0.919192914 1 253.7617001 270.7559971 3094 histidine triad nucleotide binding protein 1 "GO:0000118,GO:0000166,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006355,GO:0007165,GO:0009154,GO:0016787,GO:0043530,GO:0070062,GO:0072332" "histone deacetylase complex|nucleotide binding|protein kinase C binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|regulation of transcription, DNA-templated|signal transduction|purine ribonucleotide catabolic process|hydrolase activity|adenosine 5'-monophosphoramidase activity|extracellular exosome|intrinsic apoptotic signaling pathway by p53 class mediator" HINT2 686.6424531 701.3345741 671.9503321 0.958102391 -0.061748253 0.874208463 1 46.98428839 46.95485535 84681 histidine triad nucleotide binding protein 2 "GO:0000166,GO:0005737,GO:0005739,GO:0006694,GO:0006915,GO:0016042,GO:0016787,GO:2000757" nucleotide binding|cytoplasm|mitochondrion|steroid biosynthetic process|apoptotic process|lipid catabolic process|hydrolase activity|negative regulation of peptidyl-lysine acetylation HINT3 396.5538358 369.4439725 423.6636991 1.14676035 0.197563928 0.652562539 1 5.627378612 6.731234705 135114 histidine triad nucleotide binding protein 3 "GO:0000166,GO:0005634,GO:0005737,GO:0042802,GO:0043530" nucleotide binding|nucleus|cytoplasm|identical protein binding|adenosine 5'-monophosphoramidase activity HIP1 2353.418627 2264.366765 2442.470489 1.07865498 0.109233477 0.733261239 1 13.57989206 15.27899542 3092 huntingtin interacting protein 1 "GO:0005154,GO:0005200,GO:0005515,GO:0005546,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0006915,GO:0006919,GO:0007015,GO:0016020,GO:0030100,GO:0030136,GO:0030154,GO:0030276,GO:0030665,GO:0031234,GO:0032051,GO:0032266,GO:0035091,GO:0035254,GO:0035612,GO:0035615,GO:0042803,GO:0042981,GO:0043231,GO:0043325,GO:0045742,GO:0046982,GO:0048260,GO:0048268,GO:0050821,GO:0051015,GO:0051897,GO:0061024,GO:0072583,GO:0080025,GO:0097190,GO:0098793,GO:0098794,GO:0098888,GO:0098890,GO:0098978,GO:0099637,GO:2000588" "epidermal growth factor receptor binding|structural constituent of cytoskeleton|protein binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|actin filament organization|membrane|regulation of endocytosis|clathrin-coated vesicle|cell differentiation|clathrin binding|clathrin-coated vesicle membrane|extrinsic component of cytoplasmic side of plasma membrane|clathrin light chain binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol binding|glutamate receptor binding|AP-2 adaptor complex binding|clathrin adaptor activity|protein homodimerization activity|regulation of apoptotic process|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|positive regulation of epidermal growth factor receptor signaling pathway|protein heterodimerization activity|positive regulation of receptor-mediated endocytosis|clathrin coat assembly|protein stabilization|actin filament binding|positive regulation of protein kinase B signaling|membrane organization|clathrin-dependent endocytosis|phosphatidylinositol-3,5-bisphosphate binding|apoptotic signaling pathway|presynapse|postsynapse|extrinsic component of presynaptic membrane|extrinsic component of postsynaptic membrane|glutamatergic synapse|neurotransmitter receptor transport|positive regulation of platelet-derived growth factor receptor-beta signaling pathway" "hsa05016,hsa05022" Huntington disease|Pathways of neurodegeneration - multiple diseases HIP1R 711.3280034 772.3814919 650.2745149 0.841908463 -0.248264711 0.510533346 1 7.756969615 6.811972645 9026 huntingtin interacting protein 1 related "GO:0005515,GO:0005546,GO:0005547,GO:0005739,GO:0005829,GO:0005856,GO:0005886,GO:0005905,GO:0005938,GO:0006898,GO:0006915,GO:0006919,GO:0007015,GO:0014069,GO:0016324,GO:0017124,GO:0030100,GO:0030136,GO:0030276,GO:0030665,GO:0030837,GO:0032051,GO:0032092,GO:0032587,GO:0032839,GO:0032956,GO:0034316,GO:0035091,GO:0035615,GO:0042802,GO:0042803,GO:0043025,GO:0043065,GO:0043066,GO:0043197,GO:0043231,GO:0043325,GO:0045742,GO:0046982,GO:0048260,GO:0048268,GO:0048471,GO:0050821,GO:0051015,GO:0055123,GO:0060453,GO:0061024,GO:0080025,GO:0097060,GO:1901030,GO:1905445,GO:2000369,GO:2000588" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|mitochondrion|cytosol|cytoskeleton|plasma membrane|clathrin-coated pit|cell cortex|receptor-mediated endocytosis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|actin filament organization|postsynaptic density|apical plasma membrane|SH3 domain binding|regulation of endocytosis|clathrin-coated vesicle|clathrin binding|clathrin-coated vesicle membrane|negative regulation of actin filament polymerization|clathrin light chain binding|positive regulation of protein binding|ruffle membrane|dendrite cytoplasm|regulation of actin cytoskeleton organization|negative regulation of Arp2/3 complex-mediated actin nucleation|phosphatidylinositol binding|clathrin adaptor activity|identical protein binding|protein homodimerization activity|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|dendritic spine|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|positive regulation of epidermal growth factor receptor signaling pathway|protein heterodimerization activity|positive regulation of receptor-mediated endocytosis|clathrin coat assembly|perinuclear region of cytoplasm|protein stabilization|actin filament binding|digestive system development|regulation of gastric acid secretion|membrane organization|phosphatidylinositol-3,5-bisphosphate binding|synaptic membrane|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of clathrin coat assembly|regulation of clathrin-dependent endocytosis|positive regulation of platelet-derived growth factor receptor-beta signaling pathway" HIPK1 1960.070241 1945.670591 1974.469891 1.014801734 0.02119789 0.949287622 1 11.17882604 11.83295815 204851 homeodomain interacting protein kinase 1 "GO:0001654,GO:0004674,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0007224,GO:0008284,GO:0009952,GO:0010803,GO:0010842,GO:0016605,GO:0016607,GO:0018105,GO:0018107,GO:0018108,GO:0030182,GO:0034333,GO:0042771,GO:0045766,GO:0048596,GO:0060059,GO:0060216,GO:0060235,GO:0061072,GO:0072577,GO:0097191,GO:0106310,GO:0106311,GO:1901796" eye development|protein serine/threonine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|smoothened signaling pathway|positive regulation of cell population proliferation|anterior/posterior pattern specification|regulation of tumor necrosis factor-mediated signaling pathway|retina layer formation|PML body|nuclear speck|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|neuron differentiation|adherens junction assembly|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of angiogenesis|embryonic camera-type eye morphogenesis|embryonic retina morphogenesis in camera-type eye|definitive hemopoiesis|lens induction in camera-type eye|iris morphogenesis|endothelial cell apoptotic process|extrinsic apoptotic signaling pathway|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence HIPK2 4486.764023 4908.327063 4065.200983 0.828225367 -0.271904705 0.395187596 1 14.74695677 12.73992481 28996 homeodomain interacting protein kinase 2 "GO:0000122,GO:0001102,GO:0001654,GO:0001934,GO:0003713,GO:0003714,GO:0004672,GO:0004674,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0006978,GO:0007179,GO:0007224,GO:0007628,GO:0008284,GO:0009952,GO:0010842,GO:0016604,GO:0016605,GO:0018105,GO:0018107,GO:0018108,GO:0019048,GO:0030182,GO:0030218,GO:0030511,GO:0030514,GO:0030578,GO:0032092,GO:0042771,GO:0043388,GO:0043524,GO:0045766,GO:0045893,GO:0045944,GO:0046330,GO:0046332,GO:0046790,GO:0048596,GO:0050882,GO:0051091,GO:0051726,GO:0060059,GO:0060235,GO:0060395,GO:0061072,GO:0071456,GO:0090575,GO:0097193,GO:0106310,GO:0106311,GO:1901796,GO:2000059" "negative regulation of transcription by RNA polymerase II|RNA polymerase II activating transcription factor binding|eye development|positive regulation of protein phosphorylation|transcription coactivator activity|transcription corepressor activity|protein kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|transforming growth factor beta receptor signaling pathway|smoothened signaling pathway|adult walking behavior|positive regulation of cell population proliferation|anterior/posterior pattern specification|retina layer formation|nuclear body|PML body|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|modulation by virus of host process|neuron differentiation|erythrocyte differentiation|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|PML body organization|positive regulation of protein binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of DNA binding|negative regulation of neuron apoptotic process|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|SMAD binding|virion binding|embryonic camera-type eye morphogenesis|voluntary musculoskeletal movement|positive regulation of DNA-binding transcription factor activity|regulation of cell cycle|embryonic retina morphogenesis in camera-type eye|lens induction in camera-type eye|SMAD protein signal transduction|iris morphogenesis|cellular response to hypoxia|RNA polymerase II transcription regulator complex|intrinsic apoptotic signaling pathway|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|negative regulation of ubiquitin-dependent protein catabolic process" hsa04218 Cellular senescence HIPK3 1056.156941 939.8492267 1172.464656 1.247502921 0.319043194 0.361067587 1 5.87872641 7.649635644 10114 homeodomain interacting protein kinase 3 "GO:0004672,GO:0004674,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0009299,GO:0016604,GO:0016605,GO:0018105,GO:0018107,GO:0018108,GO:0043066,GO:0043508,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|apoptotic process|mRNA transcription|nuclear body|PML body|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|negative regulation of apoptotic process|negative regulation of JUN kinase activity|protein serine kinase activity|protein threonine kinase activity hsa04218 Cellular senescence HIPK4 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.020938468 0.063604477 147746 homeodomain interacting protein kinase 4 "GO:0004674,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0016572,GO:0018105,GO:0018107,GO:0018108,GO:0046777,GO:0106310,GO:0106311,GO:1901796" protein serine/threonine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|histone phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|protein autophosphorylation|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence HIRA 1458.92596 1431.087915 1486.764005 1.03890473 0.055063362 0.870390368 1 17.88293963 19.37896436 7290 histone cell cycle regulator "GO:0000417,GO:0000785,GO:0001085,GO:0005515,GO:0005634,GO:0005654,GO:0006336,GO:0006351,GO:0006357,GO:0009653,GO:0016605,GO:0031491,GO:0032991,GO:0042393,GO:0045892,GO:0070062" "HIR complex|chromatin|RNA polymerase II transcription factor binding|protein binding|nucleus|nucleoplasm|DNA replication-independent nucleosome assembly|transcription, DNA-templated|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|PML body|nucleosome binding|protein-containing complex|histone binding|negative regulation of transcription, DNA-templated|extracellular exosome" other HIRIP3 257.7166684 240.5445645 274.8887722 1.142776902 0.192543782 0.702951473 1 4.742208487 5.652727199 8479 HIRA interacting protein 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006333" protein binding|nucleus|nucleoplasm|nucleolus|chromatin assembly or disassembly HIVEP1 763.6873105 883.0116925 644.3629284 0.729733178 -0.454559046 0.220425896 1 3.566586422 2.714768328 3096 HIVEP zinc finger 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006357,GO:0016604,GO:0030509,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|nuclear body|BMP signaling pathway|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 HIVEP2 2109.846516 2115.168238 2104.524794 0.994968039 -0.007277912 0.983569268 1 9.784072463 10.15417679 3097 HIVEP zinc finger 2 "GO:0000978,GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" HIVEP3 272.5968334 281.1428032 264.0508636 0.939205488 -0.090487257 0.859540267 1 0.677751972 0.663968293 59269 HIVEP zinc finger 3 "GO:0000978,GO:0000981,GO:0005634,GO:0005737,GO:0006357,GO:0035914,GO:0045893,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|skeletal muscle cell differentiation|positive regulation of transcription, DNA-templated|metal ion binding" HJURP 1524.45693 1297.113728 1751.800133 1.350537039 0.433533207 0.190314512 1 20.80907012 29.31400129 55355 Holliday junction recognition protein "GO:0000775,GO:0000777,GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0007049,GO:0007059,GO:0034080,GO:0042393,GO:0042802,GO:0043254,GO:0051101" "chromosome, centromeric region|condensed chromosome kinetochore|DNA binding|protein binding|nucleoplasm|nucleolus|mitochondrion|cell cycle|chromosome segregation|CENP-A containing nucleosome assembly|histone binding|identical protein binding|regulation of protein-containing complex assembly|regulation of DNA binding" HK1 10175.06717 12275.89244 8074.241894 0.657731561 -0.604429196 0.073690921 1 117.4850048 80.60222866 3098 hexokinase 1 "GO:0001678,GO:0002720,GO:0004340,GO:0004396,GO:0005515,GO:0005524,GO:0005536,GO:0005739,GO:0005741,GO:0005829,GO:0006002,GO:0006013,GO:0006096,GO:0006954,GO:0008865,GO:0019158,GO:0032731,GO:0042802,GO:0042834,GO:0045087,GO:0045121,GO:0046835,GO:0051156,GO:0061621,GO:0072655,GO:0072656" cellular glucose homeostasis|positive regulation of cytokine production involved in immune response|glucokinase activity|hexokinase activity|protein binding|ATP binding|glucose binding|mitochondrion|mitochondrial outer membrane|cytosol|fructose 6-phosphate metabolic process|mannose metabolic process|glycolytic process|inflammatory response|fructokinase activity|mannokinase activity|positive regulation of interleukin-1 beta production|identical protein binding|peptidoglycan binding|innate immune response|membrane raft|carbohydrate phosphorylation|glucose 6-phosphate metabolic process|canonical glycolysis|establishment of protein localization to mitochondrion|maintenance of protein location in mitochondrion "hsa00010,hsa00051,hsa00052,hsa00500,hsa00520,hsa00524,hsa04066,hsa04910,hsa04930,hsa04973,hsa05131,hsa05230" "Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|HIF-1 signaling pathway|Insulin signaling pathway|Type II diabetes mellitus|Carbohydrate digestion and absorption|Shigellosis|Central carbon metabolism in cancer" HK2 776.2510423 1506.194657 46.30742758 0.03074465 -5.023520806 2.49E-28 3.38E-24 13.16139507 0.422072842 3099 hexokinase 2 "GO:0001666,GO:0001678,GO:0002931,GO:0004340,GO:0004396,GO:0005515,GO:0005524,GO:0005536,GO:0005739,GO:0005741,GO:0005813,GO:0005829,GO:0005886,GO:0006002,GO:0006096,GO:0007595,GO:0008637,GO:0008865,GO:0016020,GO:0016529,GO:0019158,GO:0035795,GO:0043231,GO:0045766,GO:0046324,GO:0046835,GO:0051156,GO:0061621,GO:0072655,GO:0072656,GO:1904925,GO:1990830,GO:2000378" response to hypoxia|cellular glucose homeostasis|response to ischemia|glucokinase activity|hexokinase activity|protein binding|ATP binding|glucose binding|mitochondrion|mitochondrial outer membrane|centrosome|cytosol|plasma membrane|fructose 6-phosphate metabolic process|glycolytic process|lactation|apoptotic mitochondrial changes|fructokinase activity|membrane|sarcoplasmic reticulum|mannokinase activity|negative regulation of mitochondrial membrane permeability|intracellular membrane-bounded organelle|positive regulation of angiogenesis|regulation of glucose import|carbohydrate phosphorylation|glucose 6-phosphate metabolic process|canonical glycolysis|establishment of protein localization to mitochondrion|maintenance of protein location in mitochondrion|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|cellular response to leukemia inhibitory factor|negative regulation of reactive oxygen species metabolic process "hsa00010,hsa00051,hsa00052,hsa00500,hsa00520,hsa00524,hsa04066,hsa04910,hsa04930,hsa04973,hsa05131,hsa05230" "Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|HIF-1 signaling pathway|Insulin signaling pathway|Type II diabetes mellitus|Carbohydrate digestion and absorption|Shigellosis|Central carbon metabolism in cancer" HKDC1 16.6725446 28.41876711 4.926322083 0.173347495 -2.528261108 0.043266451 0.94601832 0.338104369 0.061134207 80201 hexokinase domain containing 1 "GO:0001678,GO:0004340,GO:0005524,GO:0005536,GO:0005739,GO:0005829,GO:0006096,GO:0008865,GO:0019158,GO:0019318,GO:0031966,GO:0046835,GO:0051156" cellular glucose homeostasis|glucokinase activity|ATP binding|glucose binding|mitochondrion|cytosol|glycolytic process|fructokinase activity|mannokinase activity|hexose metabolic process|mitochondrial membrane|carbohydrate phosphorylation|glucose 6-phosphate metabolic process "hsa00010,hsa00051,hsa00052,hsa00500,hsa00520,hsa00524,hsa04066,hsa04910,hsa04930,hsa04973,hsa05131,hsa05230" "Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|HIF-1 signaling pathway|Insulin signaling pathway|Type II diabetes mellitus|Carbohydrate digestion and absorption|Shigellosis|Central carbon metabolism in cancer" HLA-A 5406.707786 5393.476016 5419.939555 1.004906583 0.007061394 0.983160589 1 177.9547447 186.531075 3105 "major histocompatibility complex, class I, A" "GO:0000139,GO:0001913,GO:0001916,GO:0002419,GO:0002474,GO:0002479,GO:0002480,GO:0002485,GO:0002486,GO:0002726,GO:0003723,GO:0005102,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005797,GO:0005886,GO:0005887,GO:0006955,GO:0009986,GO:0012507,GO:0016020,GO:0016032,GO:0016045,GO:0016567,GO:0019731,GO:0019885,GO:0030670,GO:0030881,GO:0031901,GO:0032729,GO:0036037,GO:0042270,GO:0042590,GO:0042605,GO:0042608,GO:0042610,GO:0042612,GO:0042824,GO:0046977,GO:0050776,GO:0050830,GO:0050852,GO:0055038,GO:0060333,GO:0060337,GO:0062061,GO:0070062,GO:0070971,GO:0071556,GO:2000566,GO:2000568,GO:2001187" "Golgi membrane|T cell mediated cytotoxicity|positive regulation of T cell mediated cytotoxicity|T cell mediated cytotoxicity directed against tumor cell target|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|positive regulation of T cell cytokine production|RNA binding|signaling receptor binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|Golgi medial cisterna|plasma membrane|integral component of plasma membrane|immune response|cell surface|ER to Golgi transport vesicle membrane|membrane|viral process|detection of bacterium|protein ubiquitination|antibacterial humoral response|antigen processing and presentation of endogenous peptide antigen via MHC class I|phagocytic vesicle membrane|beta-2-microglobulin binding|early endosome membrane|positive regulation of interferon-gamma production|CD8-positive, alpha-beta T cell activation|protection from natural killer cell mediated cytotoxicity|antigen processing and presentation of exogenous peptide antigen via MHC class I|peptide antigen binding|T cell receptor binding|CD8 receptor binding|MHC class I protein complex|MHC class I peptide loading complex|TAP binding|regulation of immune response|defense response to Gram-positive bacterium|T cell receptor signaling pathway|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|TAP complex binding|extracellular exosome|endoplasmic reticulum exit site|integral component of lumenal side of endoplasmic reticulum membrane|positive regulation of CD8-positive, alpha-beta T cell proliferation|positive regulation of memory T cell activation|positive regulation of CD8-positive, alpha-beta T cell activation" "hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-B 495.9292083 393.8029157 598.0555008 1.518667021 0.602805583 0.141306952 1 12.98484924 20.56910538 3106 "major histocompatibility complex, class I, B" "GO:0000139,GO:0001916,GO:0002250,GO:0002474,GO:0002479,GO:0002480,GO:0002486,GO:0002667,GO:0005102,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006952,GO:0006955,GO:0009986,GO:0012507,GO:0016020,GO:0016032,GO:0016045,GO:0030667,GO:0030670,GO:0031901,GO:0032655,GO:0032675,GO:0042270,GO:0042605,GO:0042612,GO:0043312,GO:0046977,GO:0050776,GO:0051087,GO:0055038,GO:0060333,GO:0060337,GO:0070062,GO:0071556,GO:2001198" "Golgi membrane|positive regulation of T cell mediated cytotoxicity|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|regulation of T cell anergy|signaling receptor binding|protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|defense response|immune response|cell surface|ER to Golgi transport vesicle membrane|membrane|viral process|detection of bacterium|secretory granule membrane|phagocytic vesicle membrane|early endosome membrane|regulation of interleukin-12 production|regulation of interleukin-6 production|protection from natural killer cell mediated cytotoxicity|peptide antigen binding|MHC class I protein complex|neutrophil degranulation|TAP binding|regulation of immune response|chaperone binding|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|integral component of lumenal side of endoplasmic reticulum membrane|regulation of dendritic cell differentiation" "hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-C 1304.024925 1315.382935 1292.666915 0.982730489 -0.02513228 0.943063287 1 43.20331081 44.28609519 3107 "major histocompatibility complex, class I, C" "GO:0000139,GO:0002250,GO:0002474,GO:0002479,GO:0002480,GO:0002486,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006955,GO:0009986,GO:0012507,GO:0016020,GO:0016032,GO:0030667,GO:0030670,GO:0031901,GO:0042605,GO:0042612,GO:0043312,GO:0046977,GO:0050776,GO:0055038,GO:0060333,GO:0060337,GO:0070062,GO:0071556" "Golgi membrane|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|immune response|cell surface|ER to Golgi transport vesicle membrane|membrane|viral process|secretory granule membrane|phagocytic vesicle membrane|early endosome membrane|peptide antigen binding|MHC class I protein complex|neutrophil degranulation|TAP binding|regulation of immune response|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|integral component of lumenal side of endoplasmic reticulum membrane" "hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DMA 18.52430722 20.29911937 16.74949508 0.825134075 -0.277299535 0.849424231 1 0.940602731 0.809555611 3108 "major histocompatibility complex, class II, DM alpha" "GO:0002250,GO:0002503,GO:0005515,GO:0005765,GO:0009986,GO:0016020,GO:0016021,GO:0019886,GO:0023026,GO:0031902,GO:0042613,GO:0043231" adaptive immune response|peptide antigen assembly with MHC class II protein complex|protein binding|lysosomal membrane|cell surface|membrane|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|MHC class II protein complex binding|late endosome membrane|MHC class II protein complex|intracellular membrane-bounded organelle "hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416" Phagosome|Cell adhesion molecules|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DMB 4.537610306 7.104691779 1.970528833 0.277355992 -1.850189203 0.383956367 1 0.266934403 0.07722502 3109 "major histocompatibility complex, class II, DM beta" "GO:0002250,GO:0002399,GO:0002503,GO:0005515,GO:0005765,GO:0016021,GO:0019886,GO:0023026,GO:0031902,GO:0042102,GO:0042613,GO:0043231,GO:2001190" adaptive immune response|MHC class II protein complex assembly|peptide antigen assembly with MHC class II protein complex|protein binding|lysosomal membrane|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|MHC class II protein complex binding|late endosome membrane|positive regulation of T cell proliferation|MHC class II protein complex|intracellular membrane-bounded organelle|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell "hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416" Phagosome|Cell adhesion molecules|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DPA1 176.9210268 105.5554207 248.286633 2.352192159 1.234005924 0.029300273 0.763169617 3.054862675 7.495151574 3113 "major histocompatibility complex, class II, DP alpha 1" "GO:0000139,GO:0002250,GO:0005765,GO:0005886,GO:0005887,GO:0006955,GO:0009986,GO:0010008,GO:0012507,GO:0019886,GO:0030658,GO:0030666,GO:0030669,GO:0032395,GO:0032588,GO:0032729,GO:0042102,GO:0042605,GO:0042613,GO:0043231,GO:0050852,GO:0050870,GO:0060333,GO:0071346,GO:0071556" Golgi membrane|adaptive immune response|lysosomal membrane|plasma membrane|integral component of plasma membrane|immune response|cell surface|endosome membrane|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|transport vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|MHC class II receptor activity|trans-Golgi network membrane|positive regulation of interferon-gamma production|positive regulation of T cell proliferation|peptide antigen binding|MHC class II protein complex|intracellular membrane-bounded organelle|T cell receptor signaling pathway|positive regulation of T cell activation|interferon-gamma-mediated signaling pathway|cellular response to interferon-gamma|integral component of lumenal side of endoplasmic reticulum membrane "hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416" Phagosome|Cell adhesion molecules|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DPB1 505.9424344 438.4609783 573.4238904 1.307810544 0.387153559 0.342447559 1 5.564144765 7.590304254 3115 "major histocompatibility complex, class II, DP beta 1" "GO:0000139,GO:0002250,GO:0005515,GO:0005765,GO:0005886,GO:0009986,GO:0010008,GO:0012507,GO:0016020,GO:0019886,GO:0030658,GO:0030666,GO:0030669,GO:0032588,GO:0032729,GO:0042102,GO:0042605,GO:0042613,GO:0050852,GO:0050870,GO:0060333,GO:0071556" Golgi membrane|adaptive immune response|protein binding|lysosomal membrane|plasma membrane|cell surface|endosome membrane|ER to Golgi transport vesicle membrane|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|transport vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|trans-Golgi network membrane|positive regulation of interferon-gamma production|positive regulation of T cell proliferation|peptide antigen binding|MHC class II protein complex|T cell receptor signaling pathway|positive regulation of T cell activation|interferon-gamma-mediated signaling pathway|integral component of lumenal side of endoplasmic reticulum membrane "hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416" Phagosome|Cell adhesion molecules|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-E 5643.766314 5602.556945 5684.975683 1.014710915 0.021068771 0.948577398 1 105.9162914 112.1039789 3133 "major histocompatibility complex, class I, E" "GO:0000139,GO:0001815,GO:0001916,GO:0002250,GO:0002474,GO:0002476,GO:0002477,GO:0002479,GO:0002480,GO:0002486,GO:0002519,GO:0002639,GO:0002715,GO:0002717,GO:0002729,GO:0005102,GO:0005515,GO:0005615,GO:0005886,GO:0006955,GO:0009897,GO:0009986,GO:0012507,GO:0016032,GO:0019731,GO:0030670,GO:0030881,GO:0031901,GO:0032398,GO:0032736,GO:0032753,GO:0032759,GO:0032760,GO:0032819,GO:0036037,GO:0042270,GO:0042288,GO:0042605,GO:0042608,GO:0042612,GO:0045087,GO:0045953,GO:0045954,GO:0046703,GO:0050776,GO:0050830,GO:0055038,GO:0060333,GO:0060337,GO:0070062,GO:0071556,GO:2000566,GO:2001187" "Golgi membrane|positive regulation of antibody-dependent cellular cytotoxicity|positive regulation of T cell mediated cytotoxicity|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|natural killer cell tolerance induction|positive regulation of immunoglobulin production|regulation of natural killer cell mediated immunity|positive regulation of natural killer cell mediated immunity|positive regulation of natural killer cell cytokine production|signaling receptor binding|protein binding|extracellular space|plasma membrane|immune response|external side of plasma membrane|cell surface|ER to Golgi transport vesicle membrane|viral process|antibacterial humoral response|phagocytic vesicle membrane|beta-2-microglobulin binding|early endosome membrane|MHC class Ib protein complex|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of TRAIL production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell proliferation|CD8-positive, alpha-beta T cell activation|protection from natural killer cell mediated cytotoxicity|MHC class I protein binding|peptide antigen binding|T cell receptor binding|MHC class I protein complex|innate immune response|negative regulation of natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding|regulation of immune response|defense response to Gram-positive bacterium|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|integral component of lumenal side of endoplasmic reticulum membrane|positive regulation of CD8-positive, alpha-beta T cell proliferation|positive regulation of CD8-positive, alpha-beta T cell activation" "hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-F 276.5703043 249.6791682 303.4614403 1.215405524 0.281437754 0.564802855 1 2.190053525 2.776462837 3134 "major histocompatibility complex, class I, F" "GO:0000139,GO:0001916,GO:0002474,GO:0002476,GO:0002477,GO:0002479,GO:0002480,GO:0002486,GO:0002725,GO:0002728,GO:0002729,GO:0005102,GO:0005515,GO:0005615,GO:0005765,GO:0005783,GO:0005886,GO:0006955,GO:0009897,GO:0009986,GO:0012507,GO:0016020,GO:0030670,GO:0030881,GO:0031901,GO:0032398,GO:0042605,GO:0042612,GO:0043322,GO:0043323,GO:0045953,GO:0046978,GO:0046979,GO:0050776,GO:0055038,GO:0060333,GO:0060337,GO:0071556,GO:0071889,GO:1901215" "Golgi membrane|positive regulation of T cell mediated cytotoxicity|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|negative regulation of T cell cytokine production|negative regulation of natural killer cell cytokine production|positive regulation of natural killer cell cytokine production|signaling receptor binding|protein binding|extracellular space|lysosomal membrane|endoplasmic reticulum|plasma membrane|immune response|external side of plasma membrane|cell surface|ER to Golgi transport vesicle membrane|membrane|phagocytic vesicle membrane|beta-2-microglobulin binding|early endosome membrane|MHC class Ib protein complex|peptide antigen binding|MHC class I protein complex|negative regulation of natural killer cell degranulation|positive regulation of natural killer cell degranulation|negative regulation of natural killer cell mediated cytotoxicity|TAP1 binding|TAP2 binding|regulation of immune response|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|integral component of lumenal side of endoplasmic reticulum membrane|14-3-3 protein binding|negative regulation of neuron death" "hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLCS 912.9751585 817.0395545 1008.910763 1.23483711 0.304320746 0.395903082 1 3.37219225 4.343481023 3141 holocarboxylase synthetase "GO:0000785,GO:0004077,GO:0004078,GO:0004079,GO:0004080,GO:0005515,GO:0005524,GO:0005652,GO:0005737,GO:0005739,GO:0005829,GO:0006768,GO:0009305,GO:0009374,GO:0016363,GO:0016570,GO:0018215,GO:0018271,GO:0019899,GO:0070781,GO:0071110" chromatin|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|protein binding|ATP binding|nuclear lamina|cytoplasm|mitochondrion|cytosol|biotin metabolic process|protein biotinylation|biotin binding|nuclear matrix|histone modification|protein phosphopantetheinylation|biotin-protein ligase activity|enzyme binding|response to biotin|histone biotinylation hsa00780 Biotin metabolism HLTF 1134.986259 839.3685858 1430.603933 1.704381075 0.769247938 0.02631307 0.720384826 7.895813105 14.03716785 6596 helicase like transcription factor "GO:0003677,GO:0003723,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006325,GO:0008094,GO:0008270,GO:0016020,GO:0016567,GO:0031625,GO:0045944,GO:0061630" DNA binding|RNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|chromatin organization|DNA-dependent ATPase activity|zinc ion binding|membrane|protein ubiquitination|ubiquitin protein ligase binding|positive regulation of transcription by RNA polymerase II|ubiquitin protein ligase activity HLX 223.6090014 198.9313698 248.286633 1.248101962 0.319735798 0.541515919 1 4.503876662 5.863439988 3142 H2.0 like homeobox "GO:0000785,GO:0000981,GO:0001889,GO:0005515,GO:0005634,GO:0006357,GO:0007275,GO:0007519,GO:0008284,GO:0030154,GO:0043565,GO:0045627,GO:0045629,GO:0046622,GO:0048484,GO:0048557" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|liver development|protein binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|skeletal muscle tissue development|positive regulation of cell population proliferation|cell differentiation|sequence-specific DNA binding|positive regulation of T-helper 1 cell differentiation|negative regulation of T-helper 2 cell differentiation|positive regulation of organ growth|enteric nervous system development|embryonic digestive tract morphogenesis" HM13 6199.624692 6826.593843 5572.65554 0.816315672 -0.29280094 0.367776693 1 66.65565749 56.7559086 81502 histocompatibility minor 13 "GO:0001701,GO:0005515,GO:0005783,GO:0005789,GO:0005791,GO:0005886,GO:0006465,GO:0006509,GO:0008233,GO:0009986,GO:0016020,GO:0031293,GO:0031625,GO:0033619,GO:0036513,GO:0042500,GO:0042803,GO:0071458,GO:0071556,GO:1904211" "in utero embryonic development|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|plasma membrane|signal peptide processing|membrane protein ectodomain proteolysis|peptidase activity|cell surface|membrane|membrane protein intracellular domain proteolysis|ubiquitin protein ligase binding|membrane protein proteolysis|Derlin-1 retrotranslocation complex|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane|membrane protein proteolysis involved in retrograde protein transport, ER to cytosol" HMBOX1 1033.08958 979.4325095 1086.746651 1.109567674 0.149997662 0.670057226 1 2.810629575 3.252919659 79618 homeobox containing 1 "GO:0000122,GO:0000781,GO:0000785,GO:0003691,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0015030,GO:0016604,GO:0016605,GO:0032212,GO:0035563,GO:0042162,GO:0042802,GO:0043565,GO:0044877,GO:0045892,GO:0045893,GO:0051972,GO:0051973,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|chromatin|double-stranded telomeric DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|Cajal body|nuclear body|PML body|positive regulation of telomere maintenance via telomerase|positive regulation of chromatin binding|telomeric DNA binding|identical protein binding|sequence-specific DNA binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of telomerase activity|positive regulation of telomerase activity|sequence-specific double-stranded DNA binding" HMBS 605.2690641 695.2448383 515.2932899 0.741168091 -0.432127323 0.268241628 1 15.51859779 11.99734426 3145 hydroxymethylbilane synthase "GO:0004418,GO:0005515,GO:0005737,GO:0005829,GO:0006782,GO:0006783,GO:0018160" hydroxymethylbilane synthase activity|protein binding|cytoplasm|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|peptidyl-pyrromethane cofactor linkage hsa00860 Porphyrin and chlorophyll metabolism HMCES 851.1788891 734.8281211 967.529657 1.316674783 0.396899046 0.274308721 1 13.47933793 18.51241208 56941 "5-hydroxymethylcytosine binding, ES cell specific" "GO:0003697,GO:0003906,GO:0005515,GO:0005657,GO:0006508,GO:0006974,GO:0008233,GO:0018142,GO:0045830,GO:0097681" single-stranded DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|protein binding|replication fork|proteolysis|cellular response to DNA damage stimulus|peptidase activity|protein-DNA covalent cross-linking|positive regulation of isotype switching|double-strand break repair via alternative nonhomologous end joining HMCN1 129.4447423 160.363043 98.52644165 0.614396184 -0.70275884 0.259416142 1 0.44200394 0.283263476 83872 hemicentin 1 "GO:0005201,GO:0005509,GO:0005515,GO:0005604,GO:0005912,GO:0005938,GO:0007049,GO:0007156,GO:0007157,GO:0007601,GO:0009617,GO:0032154,GO:0051301,GO:0062023,GO:0070062" extracellular matrix structural constituent|calcium ion binding|protein binding|basement membrane|adherens junction|cell cortex|cell cycle|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|visual perception|response to bacterium|cleavage furrow|cell division|collagen-containing extracellular matrix|extracellular exosome HMG20A 1934.761168 1831.995523 2037.526813 1.112189843 0.153403067 0.635545923 1 21.49770861 24.93945888 10363 high mobility group 20A "GO:0000122,GO:0003677,GO:0005515,GO:0005634,GO:0006325,GO:0006355,GO:0010468,GO:0033234,GO:0042802,GO:0045665" "negative regulation of transcription by RNA polymerase II|DNA binding|protein binding|nucleus|chromatin organization|regulation of transcription, DNA-templated|regulation of gene expression|negative regulation of protein sumoylation|identical protein binding|negative regulation of neuron differentiation" HMG HMG20B 1414.81051 1277.829564 1551.791456 1.21439627 0.280239264 0.401749303 1 30.92095533 39.16780714 10362 high mobility group 20B "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006325,GO:0007049,GO:0007596,GO:0010468,GO:0016604,GO:0033234,GO:0035914,GO:0045666" DNA binding|protein binding|nucleus|nucleoplasm|chromosome|chromatin organization|cell cycle|blood coagulation|regulation of gene expression|nuclear body|negative regulation of protein sumoylation|skeletal muscle cell differentiation|positive regulation of neuron differentiation HMGA1 38413.15368 33521.96572 43304.34164 1.291819877 0.369404924 0.364611782 1 827.3729559 1114.857124 3159 high mobility group AT-hook 1 "GO:0000987,GO:0003677,GO:0003680,GO:0003682,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0005925,GO:0006268,GO:0006337,GO:0006355,GO:0008134,GO:0008285,GO:0009615,GO:0019899,GO:0030374,GO:0030527,GO:0031936,GO:0035985,GO:0035986,GO:0042974,GO:0042975,GO:0045892,GO:0045893,GO:0045944,GO:0046965,GO:0051169,GO:0075713,GO:0090402,GO:0090575,GO:2000774" "cis-regulatory region sequence-specific DNA binding|DNA binding|minor groove of adenine-thymine-rich DNA binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|focal adhesion|DNA unwinding involved in DNA replication|nucleosome disassembly|regulation of transcription, DNA-templated|transcription factor binding|negative regulation of cell population proliferation|response to virus|enzyme binding|nuclear receptor coactivator activity|structural constituent of chromatin|negative regulation of chromatin silencing|senescence-associated heterochromatin focus|senescence-associated heterochromatin focus assembly|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|nuclear transport|establishment of integrated proviral latency|oncogene-induced cell senescence|RNA polymerase II transcription regulator complex|positive regulation of cellular senescence" HMGA2 3492.756928 4108.54176 2876.972096 0.700241659 -0.514075202 0.106623851 1 34.32582416 25.07176147 8091 high mobility group AT-hook 2 "GO:0000122,GO:0000228,GO:0000976,GO:0001837,GO:0002062,GO:0003131,GO:0003680,GO:0003712,GO:0003714,GO:0003906,GO:0005515,GO:0005634,GO:0005654,GO:0006284,GO:0006325,GO:0006355,GO:0007095,GO:0007275,GO:0008134,GO:0008301,GO:0009615,GO:0010564,GO:0010628,GO:0030261,GO:0031052,GO:0031492,GO:0031507,GO:0032993,GO:0035497,GO:0035500,GO:0035501,GO:0035978,GO:0035985,GO:0035986,GO:0035987,GO:0035988,GO:0040008,GO:0042769,GO:0043065,GO:0043066,GO:0043392,GO:0043922,GO:0045444,GO:0045766,GO:0045869,GO:0045892,GO:0045893,GO:0045944,GO:0046332,GO:0048333,GO:0048762,GO:0048863,GO:0051301,GO:0051575,GO:0070742,GO:0071141,GO:0071158,GO:0071864,GO:0071902,GO:0090402,GO:2000036,GO:2000648,GO:2000685,GO:2000773,GO:2000774,GO:2001022,GO:2001033,GO:2001038" "negative regulation of transcription by RNA polymerase II|nuclear chromosome|transcription regulatory region sequence-specific DNA binding|epithelial to mesenchymal transition|chondrocyte differentiation|mesodermal-endodermal cell signaling|minor groove of adenine-thymine-rich DNA binding|transcription coregulator activity|transcription corepressor activity|DNA-(apurinic or apyrimidinic site) endonuclease activity|protein binding|nucleus|nucleoplasm|base-excision repair|chromatin organization|regulation of transcription, DNA-templated|mitotic G2 DNA damage checkpoint|multicellular organism development|transcription factor binding|DNA binding, bending|response to virus|regulation of cell cycle process|positive regulation of gene expression|chromosome condensation|chromosome breakage|nucleosomal DNA binding|heterochromatin assembly|protein-DNA complex|cAMP response element binding|MH2 domain binding|MH1 domain binding|histone H2A-S139 phosphorylation|senescence-associated heterochromatin focus|senescence-associated heterochromatin focus assembly|endodermal cell differentiation|chondrocyte proliferation|regulation of growth|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of DNA binding|negative regulation by host of viral transcription|fat cell differentiation|positive regulation of angiogenesis|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|mesodermal cell differentiation|mesenchymal cell differentiation|stem cell differentiation|cell division|5'-deoxyribose-5-phosphate lyase activity|C2H2 zinc finger domain binding|SMAD protein complex|positive regulation of cell cycle arrest|positive regulation of cell proliferation in bone marrow|positive regulation of protein serine/threonine kinase activity|oncogene-induced cell senescence|regulation of stem cell population maintenance|positive regulation of stem cell proliferation|positive regulation of cellular response to X-ray|negative regulation of cellular senescence|positive regulation of cellular senescence|positive regulation of response to DNA damage stimulus|negative regulation of double-strand break repair via nonhomologous end joining|regulation of cellular response to drug" "hsa05202,hsa05206" Transcriptional misregulation in cancer|MicroRNAs in cancer HMGB1 5050.893719 5384.341412 4717.446026 0.876141698 -0.19076388 0.552759789 1 37.95906149 34.69011551 3146 high mobility group box 1 "GO:0000122,GO:0000400,GO:0000405,GO:0000793,GO:0000976,GO:0001530,GO:0001654,GO:0001773,GO:0001786,GO:0001935,GO:0002218,GO:0002224,GO:0002270,GO:0002281,GO:0002407,GO:0002437,GO:0002643,GO:0002840,GO:0003684,GO:0003690,GO:0003697,GO:0003713,GO:0003723,GO:0003725,GO:0003727,GO:0005125,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005769,GO:0005793,GO:0006265,GO:0006284,GO:0006303,GO:0006309,GO:0006310,GO:0006342,GO:0006357,GO:0006914,GO:0006954,GO:0007204,GO:0008134,GO:0008301,GO:0009986,GO:0010508,GO:0010858,GO:0016032,GO:0016829,GO:0017053,GO:0017055,GO:0019958,GO:0030295,GO:0030324,GO:0031175,GO:0031497,GO:0032072,GO:0032147,GO:0032392,GO:0032425,GO:0032640,GO:0032689,GO:0032727,GO:0032728,GO:0032731,GO:0032732,GO:0032733,GO:0032735,GO:0032755,GO:0032757,GO:0032760,GO:0033151,GO:0034137,GO:0034145,GO:0034165,GO:0034774,GO:0035711,GO:0035767,GO:0035868,GO:0042056,GO:0042104,GO:0043005,GO:0043065,GO:0043277,GO:0043280,GO:0043312,GO:0043371,GO:0043388,GO:0043410,GO:0043536,GO:0043537,GO:0045063,GO:0045087,GO:0045639,GO:0045819,GO:0045944,GO:0046330,GO:0050786,GO:0050918,GO:0051106,GO:0051384,GO:0070182,GO:0070374,GO:0070491,GO:0071222,GO:0071639,GO:0090026,GO:0090303,GO:0097100,GO:0097350,GO:0098761,GO:1901224,GO:1903672,GO:1904813,GO:1905564,GO:2000343,GO:2000426,GO:2000819,GO:2001200" "negative regulation of transcription by RNA polymerase II|four-way junction DNA binding|bubble DNA binding|condensed chromosome|transcription regulatory region sequence-specific DNA binding|lipopolysaccharide binding|eye development|myeloid dendritic cell activation|phosphatidylserine binding|endothelial cell proliferation|activation of innate immune response|toll-like receptor signaling pathway|plasmacytoid dendritic cell activation|macrophage activation involved in immune response|dendritic cell chemotaxis|inflammatory response to antigenic stimulus|regulation of tolerance induction|regulation of T cell mediated immune response to tumor cell|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|transcription coactivator activity|RNA binding|double-stranded RNA binding|single-stranded RNA binding|cytokine activity|integrin binding|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|early endosome|endoplasmic reticulum-Golgi intermediate compartment|DNA topological change|base-excision repair|double-strand break repair via nonhomologous end joining|apoptotic DNA fragmentation|DNA recombination|chromatin silencing|regulation of transcription by RNA polymerase II|autophagy|inflammatory response|positive regulation of cytosolic calcium ion concentration|transcription factor binding|DNA binding, bending|cell surface|positive regulation of autophagy|calcium-dependent protein kinase regulator activity|viral process|lyase activity|transcription repressor complex|negative regulation of RNA polymerase II transcription preinitiation complex assembly|C-X-C chemokine binding|protein kinase activator activity|lung development|neuron projection development|chromatin assembly|regulation of restriction endodeoxyribonuclease activity|activation of protein kinase activity|DNA geometric change|positive regulation of mismatch repair|tumor necrosis factor production|negative regulation of interferon-gamma production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|V(D)J recombination|positive regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of toll-like receptor 9 signaling pathway|secretory granule lumen|T-helper 1 cell activation|endothelial cell chemotaxis|alphav-beta3 integrin-HMGB1 complex|chemoattractant activity|positive regulation of activated T cell proliferation|neuron projection|positive regulation of apoptotic process|apoptotic cell clearance|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|negative regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of DNA binding|positive regulation of MAPK cascade|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|T-helper 1 cell differentiation|innate immune response|positive regulation of myeloid cell differentiation|positive regulation of glycogen catabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|RAGE receptor binding|positive chemotaxis|positive regulation of DNA ligation|response to glucocorticoid|DNA polymerase binding|positive regulation of ERK1 and ERK2 cascade|repressing transcription factor binding|cellular response to lipopolysaccharide|positive regulation of monocyte chemotactic protein-1 production|positive regulation of monocyte chemotaxis|positive regulation of wound healing|supercoiled DNA binding|neutrophil clearance|cellular response to interleukin-7|positive regulation of NIK/NF-kappaB signaling|positive regulation of sprouting angiogenesis|ficolin-1-rich granule lumen|positive regulation of vascular endothelial cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of apoptotic cell clearance|regulation of nucleotide-excision repair|positive regulation of dendritic cell differentiation" "hsa03410,hsa04140,hsa04217" Base excision repair|Autophagy - animal|Necroptosis HMGB2 3225.795793 2629.750914 3821.840672 1.453309 0.539341479 0.090477396 1 84.99528181 128.8453386 3148 high mobility group box 2 "GO:0000400,GO:0000785,GO:0000793,GO:0000976,GO:0000987,GO:0001938,GO:0002437,GO:0003677,GO:0003684,GO:0003690,GO:0003697,GO:0003713,GO:0003723,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006265,GO:0006303,GO:0006309,GO:0006325,GO:0006334,GO:0006357,GO:0007289,GO:0008134,GO:0008301,GO:0008584,GO:0019904,GO:0032075,GO:0032392,GO:0032496,GO:0032728,GO:0032991,GO:0033151,GO:0042056,GO:0043388,GO:0044378,GO:0045087,GO:0045089,GO:0045648,GO:0045654,GO:0045892,GO:0045893,GO:0045944,GO:0048471,GO:0048545,GO:0050767,GO:0050786,GO:0050829,GO:0050830,GO:0050918,GO:0060326,GO:0071222,GO:0072091,GO:0097100,GO:1902042" "four-way junction DNA binding|chromatin|condensed chromosome|transcription regulatory region sequence-specific DNA binding|cis-regulatory region sequence-specific DNA binding|positive regulation of endothelial cell proliferation|inflammatory response to antigenic stimulus|DNA binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|transcription coactivator activity|RNA binding|protein binding|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA topological change|double-strand break repair via nonhomologous end joining|apoptotic DNA fragmentation|chromatin organization|nucleosome assembly|regulation of transcription by RNA polymerase II|spermatid nucleus differentiation|transcription factor binding|DNA binding, bending|male gonad development|protein domain specific binding|positive regulation of nuclease activity|DNA geometric change|response to lipopolysaccharide|positive regulation of interferon-beta production|protein-containing complex|V(D)J recombination|chemoattractant activity|positive regulation of DNA binding|non-sequence-specific DNA binding, bending|innate immune response|positive regulation of innate immune response|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|response to steroid hormone|regulation of neurogenesis|RAGE receptor binding|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|positive chemotaxis|cell chemotaxis|cellular response to lipopolysaccharide|regulation of stem cell proliferation|supercoiled DNA binding|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors" HMGB3 1573.003348 1483.865626 1662.141071 1.12014258 0.163682381 0.620288239 1 19.24028653 22.4802311 3149 high mobility group box 3 "GO:0000400,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0006310,GO:0006357,GO:0007275,GO:0008301,GO:0032392,GO:0045087,GO:0045578,GO:0045638" "four-way junction DNA binding|double-stranded DNA binding|RNA binding|protein binding|nucleus|cytoplasm|DNA recombination|regulation of transcription by RNA polymerase II|multicellular organism development|DNA binding, bending|DNA geometric change|innate immune response|negative regulation of B cell differentiation|negative regulation of myeloid cell differentiation" HMGCL 480.3201163 505.4480723 455.1921604 0.900571563 -0.151087172 0.71756115 1 16.30519856 15.31652524 3155 3-hydroxy-3-methylglutaryl-CoA lyase "GO:0000062,GO:0000287,GO:0001889,GO:0004419,GO:0005198,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006552,GO:0006625,GO:0006629,GO:0006637,GO:0007005,GO:0007584,GO:0030145,GO:0031406,GO:0032991,GO:0042594,GO:0046872,GO:0046951,GO:0070542" fatty-acyl-CoA binding|magnesium ion binding|liver development|hydroxymethylglutaryl-CoA lyase activity|structural molecule activity|mitochondrion|mitochondrial matrix|peroxisome|peroxisomal matrix|cytosol|leucine catabolic process|protein targeting to peroxisome|lipid metabolic process|acyl-CoA metabolic process|mitochondrion organization|response to nutrient|manganese ion binding|carboxylic acid binding|protein-containing complex|response to starvation|metal ion binding|ketone body biosynthetic process|response to fatty acid "hsa00072,hsa00280,hsa00650,hsa04146" "Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism|Peroxisome" HMGCR 1308.805511 1271.739828 1345.871193 1.058291297 0.081736788 0.810487648 1 12.81009067 14.14077976 3156 3-hydroxy-3-methylglutaryl-CoA reductase "GO:0004420,GO:0005515,GO:0005778,GO:0005783,GO:0005789,GO:0006695,GO:0008299,GO:0015936,GO:0016021,GO:0016126,GO:0019216,GO:0042177,GO:0042282,GO:0045540,GO:0050709,GO:0055114,GO:0070402,GO:0120225,GO:1900222" hydroxymethylglutaryl-CoA reductase (NADPH) activity|protein binding|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|isoprenoid biosynthetic process|coenzyme A metabolic process|integral component of membrane|sterol biosynthetic process|regulation of lipid metabolic process|negative regulation of protein catabolic process|hydroxymethylglutaryl-CoA reductase activity|regulation of cholesterol biosynthetic process|negative regulation of protein secretion|oxidation-reduction process|NADPH binding|coenzyme A binding|negative regulation of amyloid-beta clearance "hsa00900,hsa04152,hsa04976" Terpenoid backbone biosynthesis|AMPK signaling pathway|Bile secretion HMGCS1 847.4577964 783.5460076 911.3695853 1.163134744 0.218018237 0.549425747 1 6.164001413 7.478399958 3157 3-hydroxy-3-methylglutaryl-CoA synthase 1 "GO:0001889,GO:0004421,GO:0005737,GO:0005829,GO:0006084,GO:0006629,GO:0006695,GO:0007420,GO:0008144,GO:0008584,GO:0009645,GO:0010142,GO:0014074,GO:0016853,GO:0019216,GO:0033197,GO:0042493,GO:0042803,GO:0043177,GO:0045540,GO:0046690,GO:0071372,GO:0071397,GO:0071404" "liver development|hydroxymethylglutaryl-CoA synthase activity|cytoplasm|cytosol|acetyl-CoA metabolic process|lipid metabolic process|cholesterol biosynthetic process|brain development|drug binding|male gonad development|response to low light intensity stimulus|farnesyl diphosphate biosynthetic process, mevalonate pathway|response to purine-containing compound|isomerase activity|regulation of lipid metabolic process|response to vitamin E|response to drug|protein homodimerization activity|organic acid binding|regulation of cholesterol biosynthetic process|response to tellurium ion|cellular response to follicle-stimulating hormone stimulus|cellular response to cholesterol|cellular response to low-density lipoprotein particle stimulus" "hsa00072,hsa00280,hsa00650,hsa00900,hsa03320" "Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism|Terpenoid backbone biosynthesis|PPAR signaling pathway" HMGN1 4924.980042 4758.11358 5091.846505 1.070139756 0.097799219 0.760882526 1 71.82762062 80.17665038 3150 high mobility group nucleosome binding domain 1 "GO:0000785,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0006283,GO:0006325,GO:0031492,GO:0032786" "chromatin|DNA binding|chromatin binding|nucleus|nucleoplasm|cytoplasm|transcription-coupled nucleotide-excision repair|chromatin organization|nucleosomal DNA binding|positive regulation of DNA-templated transcription, elongation" other HMGN2 7241.002167 6486.583594 7995.42074 1.232608911 0.301715126 0.358228491 1 169.3415339 217.7232067 3151 high mobility group nucleosomal binding domain 2 "GO:0000785,GO:0003682,GO:0003723,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0006325,GO:0031492,GO:0031640,GO:0061844" chromatin|chromatin binding|RNA binding|protein binding|extracellular space|nucleus|cytoplasm|chromatin organization|nucleosomal DNA binding|killing of cells of other organism|antimicrobial humoral immune response mediated by antimicrobial peptide HMGN3 484.9292339 551.1210908 418.737377 0.759791966 -0.396323638 0.336251587 1 19.73998516 15.6443473 9324 high mobility group nucleosomal binding domain 3 "GO:0000785,GO:0003682,GO:0005634,GO:0005654,GO:0005829,GO:0006325,GO:0008150,GO:0031492,GO:0045944,GO:0046966,GO:0061178" chromatin|chromatin binding|nucleus|nucleoplasm|cytosol|chromatin organization|biological_process|nucleosomal DNA binding|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|regulation of insulin secretion involved in cellular response to glucose stimulus other HMGN4 1741.121822 1526.493776 1955.749867 1.281203957 0.357500159 0.273030022 1 34.01298928 45.45472172 10473 high mobility group nucleosomal binding domain 4 "GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0006325,GO:0031492" chromatin|chromatin binding|protein binding|nucleus|chromatin organization|nucleosomal DNA binding HMGN5 141.1018902 182.6920743 99.51170607 0.54469635 -0.876475895 0.147924815 1 4.408151055 2.504533604 79366 high mobility group nucleosome binding domain 5 "GO:0000785,GO:0003682,GO:0003723,GO:0005634,GO:0005654,GO:0005739,GO:0006325,GO:0006355,GO:0008284,GO:0010628,GO:0031492,GO:0043066,GO:0045893,GO:0071157" "chromatin|chromatin binding|RNA binding|nucleus|nucleoplasm|mitochondrion|chromatin organization|regulation of transcription, DNA-templated|positive regulation of cell population proliferation|positive regulation of gene expression|nucleosomal DNA binding|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|negative regulation of cell cycle arrest" HMGXB3 1951.556438 2003.523082 1899.589795 0.948124737 -0.076851219 0.81304706 1 19.29847396 19.08553664 22993 HMG-box containing 3 "GO:0003677,GO:0005575,GO:0005634,GO:0008150" DNA binding|cellular_component|nucleus|biological_process HMGXB4 1400.358151 1300.158595 1500.557706 1.154134358 0.206811185 0.536985379 1 13.15390455 15.83532517 10042 HMG-box containing 4 "GO:0003677,GO:0005515,GO:0008333,GO:0016055,GO:0016589,GO:0030178,GO:0042802" DNA binding|protein binding|endosome to lysosome transport|Wnt signaling pathway|NURF complex|negative regulation of Wnt signaling pathway|identical protein binding HMMR 963.2951511 855.6078813 1070.982421 1.251721079 0.323913123 0.361426412 1 14.36787824 18.75927866 3161 hyaluronan mediated motility receptor "GO:0005515,GO:0005540,GO:0005813,GO:0005829,GO:0005886,GO:0009986,GO:0010389,GO:0015630,GO:0016020,GO:0030214" protein binding|hyaluronic acid binding|centrosome|cytosol|plasma membrane|cell surface|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|membrane|hyaluronan catabolic process hsa04512 ECM-receptor interaction HMOX1 775.4038414 909.4005477 641.4071352 0.705307619 -0.50367547 0.173239467 1 29.63830731 21.80458885 3162 heme oxygenase 1 "GO:0001525,GO:0001935,GO:0002246,GO:0002686,GO:0004392,GO:0004630,GO:0005198,GO:0005515,GO:0005615,GO:0005634,GO:0005730,GO:0005783,GO:0005789,GO:0005829,GO:0005901,GO:0006788,GO:0006879,GO:0006979,GO:0007264,GO:0007588,GO:0008217,GO:0008219,GO:0008630,GO:0010656,GO:0014806,GO:0016020,GO:0016239,GO:0016242,GO:0019221,GO:0019899,GO:0020037,GO:0031670,GO:0032722,GO:0032764,GO:0034101,GO:0034383,GO:0034395,GO:0034605,GO:0035094,GO:0035556,GO:0042167,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043065,GO:0043123,GO:0043305,GO:0043392,GO:0043433,GO:0043524,GO:0043619,GO:0043627,GO:0045765,GO:0045766,GO:0046872,GO:0048471,GO:0048661,GO:0048662,GO:0051090,GO:0055072,GO:0071243,GO:0071276,GO:0071456,GO:0072719,GO:0090050,GO:0097421,GO:1902042,GO:1903589,GO:1904036,GO:1904706" angiogenesis|endothelial cell proliferation|wound healing involved in inflammatory response|negative regulation of leukocyte migration|heme oxygenase (decyclizing) activity|phospholipase D activity|structural molecule activity|protein binding|extracellular space|nucleus|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|caveola|heme oxidation|cellular iron ion homeostasis|response to oxidative stress|small GTPase mediated signal transduction|excretion|regulation of blood pressure|cell death|intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of muscle cell apoptotic process|smooth muscle hyperplasia|membrane|positive regulation of macroautophagy|negative regulation of macroautophagy|cytokine-mediated signaling pathway|enzyme binding|heme binding|cellular response to nutrient|positive regulation of chemokine production|negative regulation of mast cell cytokine production|erythrocyte homeostasis|low-density lipoprotein particle clearance|regulation of transcription from RNA polymerase II promoter in response to iron|cellular response to heat|response to nicotine|intracellular signal transduction|heme catabolic process|response to drug|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of mast cell degranulation|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|negative regulation of neuron apoptotic process|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to estrogen|regulation of angiogenesis|positive regulation of angiogenesis|metal ion binding|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|negative regulation of smooth muscle cell proliferation|regulation of DNA-binding transcription factor activity|iron ion homeostasis|cellular response to arsenic-containing substance|cellular response to cadmium ion|cellular response to hypoxia|cellular response to cisplatin|positive regulation of cell migration involved in sprouting angiogenesis|liver regeneration|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|negative regulation of epithelial cell apoptotic process|negative regulation of vascular associated smooth muscle cell proliferation "hsa00860,hsa04066,hsa04216,hsa04978,hsa05200,hsa05206,hsa05225,hsa05418" Porphyrin and chlorophyll metabolism|HIF-1 signaling pathway|Ferroptosis|Mineral absorption|Pathways in cancer|MicroRNAs in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis HMOX2 674.0242892 748.0225487 600.0260297 0.802149655 -0.318056672 0.404139751 1 14.84510314 12.42094248 3163 heme oxygenase 2 "GO:0001666,GO:0004392,GO:0005515,GO:0005789,GO:0005886,GO:0006788,GO:0006879,GO:0006979,GO:0016020,GO:0020037,GO:0035579,GO:0042167,GO:0043312,GO:0046872,GO:0055072" response to hypoxia|heme oxygenase (decyclizing) activity|protein binding|endoplasmic reticulum membrane|plasma membrane|heme oxidation|cellular iron ion homeostasis|response to oxidative stress|membrane|heme binding|specific granule membrane|heme catabolic process|neutrophil degranulation|metal ion binding|iron ion homeostasis "hsa00860,hsa04978" Porphyrin and chlorophyll metabolism|Mineral absorption HMSD 63.99220654 63.94222601 64.04218708 1.001563303 0.002253608 1 1 1.032668422 1.078835504 284293 histocompatibility minor serpin domain containing "GO:0002253,GO:0004867,GO:0005615,GO:0010951" activation of immune response|serine-type endopeptidase inhibitor activity|extracellular space|negative regulation of endopeptidase activity HNF1B 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.052239776 0 6928 HNF1 homeobox B "GO:0000785,GO:0000978,GO:0000981,GO:0001822,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0009743,GO:0014070,GO:0030073,GO:0031016,GO:0032922,GO:0035565,GO:0039020,GO:0042493,GO:0042802,GO:0043231,GO:0044877,GO:0045893,GO:0048598,GO:0048793,GO:0060261,GO:0065004,GO:0070365" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|kidney development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|response to carbohydrate|response to organic cyclic compound|insulin secretion|pancreas development|circadian regulation of gene expression|regulation of pronephros size|pronephric nephron tubule development|response to drug|identical protein binding|intracellular membrane-bounded organelle|protein-containing complex binding|positive regulation of transcription, DNA-templated|embryonic morphogenesis|pronephros development|positive regulation of transcription initiation from RNA polymerase II promoter|protein-DNA complex assembly|hepatocyte differentiation" hsa04950 Maturity onset diabetes of the young Homeobox HNF4G 165.5311029 101.4955968 229.5666091 2.261838111 1.177495674 0.041584034 0.936262454 1.034076428 2.439664382 3174 hepatocyte nuclear factor 4 gamma "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0004879,GO:0005654,GO:0005829,GO:0006357,GO:0006367,GO:0008270,GO:0030154,GO:0030522,GO:0045171,GO:0045944,GO:0048856,GO:0072686" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nuclear receptor activity|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|zinc ion binding|cell differentiation|intracellular receptor signaling pathway|intercellular bridge|positive regulation of transcription by RNA polymerase II|anatomical structure development|mitotic spindle" hsa04950 Maturity onset diabetes of the young ThyrH_rcpt HNMT 29.6739771 41.6131947 17.7347595 0.426181158 -1.230461284 0.217385995 1 0.417338913 0.185523554 3176 histamine N-methyltransferase "GO:0001692,GO:0001695,GO:0002347,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006548,GO:0006972,GO:0007420,GO:0007585,GO:0014075,GO:0032259,GO:0035902,GO:0042220,GO:0043005,GO:0046539,GO:0051384,GO:0070062,GO:0070555" histamine metabolic process|histamine catabolic process|response to tumor cell|nucleoplasm|cytoplasm|centrosome|cytosol|histidine catabolic process|hyperosmotic response|brain development|respiratory gaseous exchange by respiratory system|response to amine|methylation|response to immobilization stress|response to cocaine|neuron projection|histamine N-methyltransferase activity|response to glucocorticoid|extracellular exosome|response to interleukin-1 hsa00340 Histidine metabolism HNRNPA0 3586.110359 3653.841486 3518.379231 0.962926072 -0.054503054 0.864727257 1 21.23885932 21.33241697 10949 heterogeneous nuclear ribonucleoprotein A0 "GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0006397,GO:0006954,GO:0016070,GO:0019901,GO:0032496,GO:0035925,GO:0070935" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|mRNA processing|inflammatory response|RNA metabolic process|protein kinase binding|response to lipopolysaccharide|mRNA 3'-UTR AU-rich region binding|3'-UTR-mediated mRNA stabilization" HNRNPA1 19503.0583 17967.76551 21038.35109 1.170894126 0.227610631 0.53007125 1 243.056607 296.8526894 3178 heterogeneous nuclear ribonucleoprotein A1 "GO:0000381,GO:0000398,GO:0003697,GO:0003723,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006405,GO:0008543,GO:0016020,GO:0016032,GO:0016070,GO:0019904,GO:0032211,GO:0032212,GO:0035198,GO:0036002,GO:0042149,GO:0051028,GO:0051168,GO:0051170,GO:0061752,GO:0070062,GO:0071013,GO:0098505,GO:1903936,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|single-stranded DNA binding|RNA binding|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|RNA export from nucleus|fibroblast growth factor receptor signaling pathway|membrane|viral process|RNA metabolic process|protein domain specific binding|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|miRNA binding|pre-mRNA binding|cellular response to glucose starvation|mRNA transport|nuclear export|import into nucleus|telomeric repeat-containing RNA binding|extracellular exosome|catalytic step 2 spliceosome|G-rich strand telomeric DNA binding|cellular response to sodium arsenite|ribonucleoprotein complex" "hsa03040,hsa05014" Spliceosome|Amyotrophic lateral sclerosis HNRNPA1L2 189.6497922 167.4677348 211.8318496 1.264911416 0.339036354 0.539808149 1 3.689277936 4.867628402 144983 heterogeneous nuclear ribonucleoprotein A1 like 2 "GO:0003723,GO:0005681,GO:0005737,GO:0006397,GO:0008380,GO:0051028" RNA binding|spliceosomal complex|cytoplasm|mRNA processing|RNA splicing|mRNA transport "hsa03040,hsa05014" Spliceosome|Amyotrophic lateral sclerosis HNRNPA2B1 14570.41264 14403.24015 14737.58514 1.023213179 0.033106752 0.924644207 1 198.7124222 212.083593 3181 heterogeneous nuclear ribonucleoprotein A2/B1 "GO:0000122,GO:0000398,GO:0000781,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006397,GO:0006406,GO:0015030,GO:0016020,GO:0016032,GO:0016070,GO:0016363,GO:0031053,GO:0035198,GO:0035722,GO:0043047,GO:0044806,GO:0048025,GO:0050658,GO:0070062,GO:0071013,GO:0097157,GO:0098505,GO:1904358,GO:1905663,GO:1990247,GO:1990428,GO:1990904" "negative regulation of transcription by RNA polymerase II|mRNA splicing, via spliceosome|chromosome, telomeric region|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|mRNA processing|mRNA export from nucleus|Cajal body|membrane|viral process|RNA metabolic process|nuclear matrix|primary miRNA processing|miRNA binding|interleukin-12-mediated signaling pathway|single-stranded telomeric DNA binding|G-quadruplex DNA unwinding|negative regulation of mRNA splicing, via spliceosome|RNA transport|extracellular exosome|catalytic step 2 spliceosome|pre-mRNA intronic binding|G-rich strand telomeric DNA binding|positive regulation of telomere maintenance via telomere lengthening|positive regulation of telomerase RNA reverse transcriptase activity|N6-methyladenosine-containing RNA binding|miRNA transport|ribonucleoprotein complex" hsa05014 Amyotrophic lateral sclerosis HNRNPA3 6391.897235 6499.778021 6284.016449 0.966804778 -0.048703492 0.881494994 1 57.31038074 57.79469971 220988 heterogeneous nuclear ribonucleoprotein A3 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0016070,GO:0071013,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|RNA metabolic process|catalytic step 2 spliceosome|ribonucleoprotein complex" "hsa03040,hsa05014" Spliceosome|Amyotrophic lateral sclerosis HNRNPAB 3845.42369 3902.505698 3788.341682 0.970745971 -0.042834281 0.893744999 1 111.6656194 113.0683373 3182 heterogeneous nuclear ribonucleoprotein A/B "GO:0001837,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0010468,GO:0045893,GO:0090575,GO:1990904" "epithelial to mesenchymal transition|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of gene expression|positive regulation of transcription, DNA-templated|RNA polymerase II transcription regulator complex|ribonucleoprotein complex" HNRNPC 9539.951165 9809.549434 9270.352895 0.945033506 -0.081562614 0.807884555 1 110.7734834 109.1940437 3183 heterogeneous nuclear ribonucleoprotein C "GO:0000398,GO:0000785,GO:0001649,GO:0003723,GO:0003730,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005681,GO:0005697,GO:0005829,GO:0008266,GO:0008380,GO:0015629,GO:0016020,GO:0016070,GO:0031492,GO:0032211,GO:0032991,GO:0042802,GO:0043044,GO:0070034,GO:0070062,GO:0070935,GO:0071013,GO:1990247" "mRNA splicing, via spliceosome|chromatin|osteoblast differentiation|RNA binding|mRNA 3'-UTR binding|protein binding|extracellular region|nucleus|nucleoplasm|spliceosomal complex|telomerase holoenzyme complex|cytosol|poly(U) RNA binding|RNA splicing|actin cytoskeleton|membrane|RNA metabolic process|nucleosomal DNA binding|negative regulation of telomere maintenance via telomerase|protein-containing complex|identical protein binding|ATP-dependent chromatin remodeling|telomerase RNA binding|extracellular exosome|3'-UTR-mediated mRNA stabilization|catalytic step 2 spliceosome|N6-methyladenosine-containing RNA binding" hsa03040 Spliceosome HNRNPD 3987.01945 4253.680463 3720.358437 0.874621041 -0.193270038 0.544391709 1 70.21965756 64.06112456 3184 heterogeneous nuclear ribonucleoprotein D "GO:0000398,GO:0001889,GO:0003680,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006396,GO:0006401,GO:0008134,GO:0010468,GO:0016070,GO:0021549,GO:0032204,GO:0035925,GO:0042162,GO:0042752,GO:0042826,GO:0043488,GO:0045202,GO:0045727,GO:0045893,GO:0048255,GO:0051592,GO:0051602,GO:0061158,GO:0071230,GO:0071392,GO:0071732,GO:0097167,GO:1901355,GO:1904355,GO:1904383,GO:1904586,GO:1905663,GO:1990828,GO:1990904" "mRNA splicing, via spliceosome|liver development|minor groove of adenine-thymine-rich DNA binding|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|RNA processing|RNA catabolic process|transcription factor binding|regulation of gene expression|RNA metabolic process|cerebellum development|regulation of telomere maintenance|mRNA 3'-UTR AU-rich region binding|telomeric DNA binding|regulation of circadian rhythm|histone deacetylase binding|regulation of mRNA stability|synapse|positive regulation of translation|positive regulation of transcription, DNA-templated|mRNA stabilization|response to calcium ion|response to electrical stimulus|3'-UTR-mediated mRNA destabilization|cellular response to amino acid stimulus|cellular response to estradiol stimulus|cellular response to nitric oxide|circadian regulation of translation|response to rapamycin|positive regulation of telomere capping|response to sodium phosphate|cellular response to putrescine|positive regulation of telomerase RNA reverse transcriptase activity|hepatocyte dedifferentiation|ribonucleoprotein complex" HNRNPDL 4123.577049 4327.772249 3919.381849 0.90563496 -0.142998443 0.654172934 1 50.0768556 47.30490341 9987 heterogeneous nuclear ribonucleoprotein D like "GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0008143,GO:0010468,GO:0034046,GO:0035722" DNA binding|RNA binding|protein binding|nucleoplasm|cytosol|poly(A) binding|regulation of gene expression|poly(G) binding|interleukin-12-mediated signaling pathway HNRNPF 4547.905594 5147.856672 3947.954517 0.766912284 -0.382866517 0.23162392 1 84.75968136 67.8033168 3185 heterogeneous nuclear ribonucleoprotein F "GO:0000398,GO:0003723,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006396,GO:0008543,GO:0016020,GO:0016070,GO:0017025,GO:0035722,GO:0043484,GO:0071013,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|RNA processing|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|TBP-class protein binding|interleukin-12-mediated signaling pathway|regulation of RNA splicing|catalytic step 2 spliceosome|ribonucleoprotein complex" HNRNPH1 5830.608771 5780.17424 5881.043302 1.017450869 0.024959131 0.939081138 1 80.66834776 85.61158519 3187 heterogeneous nuclear ribonucleoprotein H1 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006396,GO:0008266,GO:0008543,GO:0016020,GO:0016070,GO:0042802,GO:0043484,GO:0071013,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|RNA processing|poly(U) RNA binding|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|identical protein binding|regulation of RNA splicing|catalytic step 2 spliceosome|ribonucleoprotein complex" HNRNPH3 2580.693297 2545.509569 2615.877026 1.027643761 0.039340232 0.902943568 1 46.22484031 49.54889105 3189 heterogeneous nuclear ribonucleoprotein H3 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006396,GO:0008380,GO:0030855,GO:0043484,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|RNA processing|RNA splicing|epithelial cell differentiation|regulation of RNA splicing|ribonucleoprotein complex" HNRNPK 12545.18357 13155.85926 11934.50788 0.907162933 -0.140566402 0.682568284 1 218.3867127 206.6462066 3190 heterogeneous nuclear ribonucleoprotein K "GO:0000398,GO:0000785,GO:0002102,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005925,GO:0006357,GO:0006396,GO:0007165,GO:0010468,GO:0010494,GO:0010988,GO:0016020,GO:0016032,GO:0016070,GO:0019904,GO:0042802,GO:0042995,GO:0043066,GO:0045296,GO:0045944,GO:0048024,GO:0048025,GO:0048260,GO:0070062,GO:0071013,GO:1902165,GO:1905599" "mRNA splicing, via spliceosome|chromatin|podosome|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|focal adhesion|regulation of transcription by RNA polymerase II|RNA processing|signal transduction|regulation of gene expression|cytoplasmic stress granule|regulation of low-density lipoprotein particle clearance|membrane|viral process|RNA metabolic process|protein domain specific binding|identical protein binding|cell projection|negative regulation of apoptotic process|cadherin binding|positive regulation of transcription by RNA polymerase II|regulation of mRNA splicing, via spliceosome|negative regulation of mRNA splicing, via spliceosome|positive regulation of receptor-mediated endocytosis|extracellular exosome|catalytic step 2 spliceosome|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of low-density lipoprotein receptor activity" "hsa03040,hsa05203,hsa05206" Spliceosome|Viral carcinogenesis|MicroRNAs in cancer HNRNPL 4611.273287 4630.229128 4592.317446 0.991812137 -0.011861215 0.971165866 1 90.64737953 93.77792135 3191 heterogeneous nuclear ribonucleoprotein L "GO:0000381,GO:0000398,GO:0000976,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006396,GO:0006417,GO:0016020,GO:0016070,GO:0035770,GO:0043484,GO:0070062,GO:0097157,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|transcription regulatory region sequence-specific DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|RNA processing|regulation of translation|membrane|RNA metabolic process|ribonucleoprotein granule|regulation of RNA splicing|extracellular exosome|pre-mRNA intronic binding|ribonucleoprotein complex" other HNRNPLL 235.4227718 130.9293199 339.9162237 2.596181084 1.376391015 0.007912215 0.364181927 1.412376606 3.824735672 92906 heterogeneous nuclear ribonucleoprotein L like "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0006397,GO:0006417,GO:0016020,GO:0033120,GO:0043484" RNA binding|mRNA binding|protein binding|nucleus|mRNA processing|regulation of translation|membrane|positive regulation of RNA splicing|regulation of RNA splicing HNRNPM 4522.657388 4836.265189 4209.049587 0.870309924 -0.200398848 0.531031433 1 81.13274943 73.65225683 4670 heterogeneous nuclear ribonucleoprotein M "GO:0000380,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005737,GO:0008543,GO:0016020,GO:0016070,GO:0016363,GO:0019904,GO:0042382,GO:0062023,GO:0070062,GO:0071013,GO:0071014,GO:1990904,GO:2000815" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|cytoplasm|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|nuclear matrix|protein domain specific binding|paraspeckles|collagen-containing extracellular matrix|extracellular exosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex|ribonucleoprotein complex|regulation of mRNA stability involved in response to oxidative stress" hsa03040 Spliceosome HNRNPR 3928.239841 3973.552616 3882.927066 0.977192815 -0.033284839 0.91755833 1 25.93381729 26.43398514 10236 heterogeneous nuclear ribonucleoprotein R "GO:0000398,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005783,GO:0006397,GO:0007623,GO:0016070,GO:0030425,GO:0030426,GO:0043086,GO:0043679,GO:0061157,GO:0071013,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|endoplasmic reticulum|mRNA processing|circadian rhythm|RNA metabolic process|dendrite|growth cone|negative regulation of catalytic activity|axon terminus|mRNA destabilization|catalytic step 2 spliceosome|ribonucleoprotein complex" HNRNPU 10242.34127 11082.30422 9402.378327 0.848413664 -0.237160239 0.481882557 1 81.73578166 72.33288783 3192 heterogeneous nuclear ribonucleoprotein U "GO:0000122,GO:0000228,GO:0000381,GO:0000398,GO:0000776,GO:0000777,GO:0000922,GO:0000978,GO:0000993,GO:0001097,GO:0001649,GO:0003677,GO:0003682,GO:0003690,GO:0003697,GO:0003714,GO:0003723,GO:0003725,GO:0003727,GO:0003730,GO:0003779,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005697,GO:0005813,GO:0006325,GO:0006396,GO:0007049,GO:0007346,GO:0008143,GO:0009048,GO:0009986,GO:0016020,GO:0016032,GO:0016070,GO:0016363,GO:0016607,GO:0017069,GO:0017130,GO:0030496,GO:0031490,GO:0032211,GO:0032839,GO:0032922,GO:0032991,GO:0033673,GO:0034046,GO:0034244,GO:0036002,GO:0036464,GO:0042802,GO:0043021,GO:0044877,GO:0045944,GO:0048255,GO:0051301,GO:0051457,GO:0055013,GO:0070034,GO:0070934,GO:0070937,GO:0071013,GO:0071385,GO:0072686,GO:0090336,GO:0090575,GO:0098577,GO:0098963,GO:0099122,GO:1901673,GO:1902275,GO:1902425,GO:1902889,GO:1990023,GO:1990280,GO:1990498,GO:1990830,GO:1990837,GO:1990841,GO:1990845,GO:1990904,GO:2000373,GO:2000648,GO:2000737" "negative regulation of transcription by RNA polymerase II|nuclear chromosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|kinetochore|condensed chromosome kinetochore|spindle pole|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II complex binding|TFIIH-class transcription factor complex binding|osteoblast differentiation|DNA binding|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|transcription corepressor activity|RNA binding|double-stranded RNA binding|single-stranded RNA binding|mRNA 3'-UTR binding|actin binding|protein binding|ATP binding|nucleus|nucleoplasm|telomerase holoenzyme complex|centrosome|chromatin organization|RNA processing|cell cycle|regulation of mitotic cell cycle|poly(A) binding|dosage compensation by inactivation of X chromosome|cell surface|membrane|viral process|RNA metabolic process|nuclear matrix|nuclear speck|snRNA binding|poly(C) RNA binding|midbody|chromatin DNA binding|negative regulation of telomere maintenance via telomerase|dendrite cytoplasm|circadian regulation of gene expression|protein-containing complex|negative regulation of kinase activity|poly(G) binding|negative regulation of transcription elongation from RNA polymerase II promoter|pre-mRNA binding|cytoplasmic ribonucleoprotein granule|identical protein binding|ribonucleoprotein complex binding|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|mRNA stabilization|cell division|maintenance of protein location in nucleus|cardiac muscle cell development|telomerase RNA binding|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|catalytic step 2 spliceosome|cellular response to glucocorticoid stimulus|mitotic spindle|positive regulation of brown fat cell differentiation|RNA polymerase II transcription regulator complex|inactive sex chromosome|dendritic transport of messenger ribonucleoprotein complex|RNA polymerase II C-terminal domain binding|regulation of mitotic spindle assembly|regulation of chromatin organization|positive regulation of attachment of mitotic spindle microtubules to kinetochore|protein localization to spindle microtubule|mitotic spindle midzone|RNA localization to chromatin|mitotic spindle microtubule|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding|adaptive thermogenesis|ribonucleoprotein complex|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|positive regulation of stem cell proliferation|negative regulation of stem cell differentiation" hsa03040 Spliceosome HNRNPUL1 5697.644096 5581.24287 5814.045322 1.041711579 0.05895589 0.855744488 1 59.53459603 64.68935668 11100 heterogeneous nuclear ribonucleoprotein U like 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006396,GO:0009615,GO:0019899" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|RNA processing|response to virus|enzyme binding" hsa05164 Influenza A HNRNPUL2 4855.301657 4675.902146 5034.701169 1.076733646 0.106661412 0.739758198 1 45.41962948 51.01146558 221092 heterogeneous nuclear ribonucleoprotein U like 2 "GO:0003723,GO:0005634,GO:0005654,GO:0008150,GO:0016020" RNA binding|nucleus|nucleoplasm|biological_process|membrane HOMER1 216.9739312 284.1876711 149.7601913 0.526976384 -0.924189785 0.07922102 1 2.006846485 1.10311613 9456 homer scaffold protein 1 "GO:0003009,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007206,GO:0007216,GO:0007268,GO:0009967,GO:0014069,GO:0030018,GO:0030424,GO:0030425,GO:0035256,GO:0035591,GO:0043034,GO:0043197,GO:0044309,GO:0044325,GO:0045177,GO:0048148,GO:0048741,GO:0048875,GO:0051262,GO:0051592,GO:0051928,GO:0051966,GO:0090279,GO:0098962,GO:0098978,GO:0099524,GO:1902950,GO:2001256,GO:2001257" "skeletal muscle contraction|protein binding|cytoplasm|cytosol|plasma membrane|phospholipase C-activating G protein-coupled glutamate receptor signaling pathway|G protein-coupled glutamate receptor signaling pathway|chemical synaptic transmission|positive regulation of signal transduction|postsynaptic density|Z disc|axon|dendrite|G protein-coupled glutamate receptor binding|signaling adaptor activity|costamere|dendritic spine|neuron spine|ion channel binding|apical part of cell|behavioral response to cocaine|skeletal muscle fiber development|chemical homeostasis within a tissue|protein tetramerization|response to calcium ion|positive regulation of calcium ion transport|regulation of synaptic transmission, glutamatergic|regulation of calcium ion import|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse|postsynaptic cytosol|regulation of dendritic spine maintenance|regulation of store-operated calcium entry|regulation of cation channel activity" "hsa04068,hsa04724" FoxO signaling pathway|Glutamatergic synapse HOMER2 1514.320732 1479.805802 1548.835663 1.046647919 0.065776217 0.844225941 1 5.673071185 6.193480535 9455 homer scaffold protein 2 "GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007216,GO:0007605,GO:0008277,GO:0014069,GO:0019904,GO:0030160,GO:0030425,GO:0032426,GO:0032703,GO:0035256,GO:0035584,GO:0042802,GO:0043025,GO:0043229,GO:0044877,GO:0045177,GO:0048148,GO:0048875,GO:0070885,GO:0098978,GO:2001256" actin binding|protein binding|cytoplasm|cytosol|plasma membrane|G protein-coupled glutamate receptor signaling pathway|sensory perception of sound|regulation of G protein-coupled receptor signaling pathway|postsynaptic density|protein domain specific binding|synaptic receptor adaptor activity|dendrite|stereocilium tip|negative regulation of interleukin-2 production|G protein-coupled glutamate receptor binding|calcium-mediated signaling using intracellular calcium source|identical protein binding|neuronal cell body|intracellular organelle|protein-containing complex binding|apical part of cell|behavioral response to cocaine|chemical homeostasis within a tissue|negative regulation of calcineurin-NFAT signaling cascade|glutamatergic synapse|regulation of store-operated calcium entry "hsa04068,hsa04724" FoxO signaling pathway|Glutamatergic synapse HOMER3 1270.296567 1198.662999 1341.930135 1.119522449 0.162883457 0.632033057 1 26.66141952 31.13379094 9454 homer scaffold protein 3 "GO:0005515,GO:0005575,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0007216,GO:0014069,GO:0030425,GO:0032703,GO:0035256,GO:0042802,GO:0070885,GO:2001256" protein binding|cellular_component|cytoplasm|cytosol|plasma membrane|protein targeting|G protein-coupled glutamate receptor signaling pathway|postsynaptic density|dendrite|negative regulation of interleukin-2 production|G protein-coupled glutamate receptor binding|identical protein binding|negative regulation of calcineurin-NFAT signaling cascade|regulation of store-operated calcium entry "hsa04068,hsa04724" FoxO signaling pathway|Glutamatergic synapse HOMEZ 185.9786801 152.2433953 219.7139649 1.443175676 0.529246928 0.338734632 1 1.546448233 2.327933214 57594 homeobox and leucine zipper encoding "GO:0000785,GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II" HOOK1 45.36397889 36.53841486 54.18954291 1.483084122 0.568600431 0.523632469 1 0.348764005 0.539527234 51361 hook microtubule tethering protein 1 "GO:0003779,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0007030,GO:0007032,GO:0007040,GO:0007275,GO:0008017,GO:0008333,GO:0015031,GO:0030705,GO:0030897,GO:0031122,GO:0042802,GO:0045022,GO:0051959,GO:0070695,GO:1905198" actin binding|protein binding|cytoplasm|centrosome|cytosol|microtubule|Golgi organization|endosome organization|lysosome organization|multicellular organism development|microtubule binding|endosome to lysosome transport|protein transport|cytoskeleton-dependent intracellular transport|HOPS complex|cytoplasmic microtubule organization|identical protein binding|early endosome to late endosome transport|dynein light intermediate chain binding|FHF complex|manchette assembly HOOK2 294.3023422 283.1727152 305.4319691 1.078606634 0.109168812 0.824512167 1 5.641895771 6.347519964 29911 hook microtubule tethering protein 2 "GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0006897,GO:0007032,GO:0007040,GO:0008017,GO:0008333,GO:0015031,GO:0030705,GO:0030897,GO:0031122,GO:0042802,GO:0043231,GO:0045022,GO:0051959,GO:0070695" protein binding|cytoplasm|centrosome|cytosol|microtubule|endocytosis|endosome organization|lysosome organization|microtubule binding|endosome to lysosome transport|protein transport|cytoskeleton-dependent intracellular transport|HOPS complex|cytoplasmic microtubule organization|identical protein binding|intracellular membrane-bounded organelle|early endosome to late endosome transport|dynein light intermediate chain binding|FHF complex HOOK3 905.3642265 970.2979058 840.4305473 0.866157231 -0.207299158 0.5643862 1 3.425018534 3.094393863 84376 hook microtubule tethering protein 3 "GO:0000242,GO:0005515,GO:0005737,GO:0005801,GO:0005813,GO:0005829,GO:0005874,GO:0007032,GO:0007040,GO:0008017,GO:0008333,GO:0015031,GO:0022027,GO:0030705,GO:0030897,GO:0031122,GO:0034451,GO:0034452,GO:0034454,GO:0042802,GO:0045022,GO:0045503,GO:0045505,GO:0050768,GO:0051645,GO:0051959,GO:0070695,GO:0071539,GO:0097150" pericentriolar material|protein binding|cytoplasm|cis-Golgi network|centrosome|cytosol|microtubule|endosome organization|lysosome organization|microtubule binding|endosome to lysosome transport|protein transport|interkinetic nuclear migration|cytoskeleton-dependent intracellular transport|HOPS complex|cytoplasmic microtubule organization|centriolar satellite|dynactin binding|microtubule anchoring at centrosome|identical protein binding|early endosome to late endosome transport|dynein light chain binding|dynein intermediate chain binding|negative regulation of neurogenesis|Golgi localization|dynein light intermediate chain binding|FHF complex|protein localization to centrosome|neuronal stem cell population maintenance HOPX 12.98658673 12.17947162 13.79370183 1.132536966 0.17955814 0.952676516 1 0.146519542 0.173086768 84525 HOP homeobox "GO:0000785,GO:0000981,GO:0001829,GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0045596,GO:0051131" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|trophectodermal cell differentiation|DNA binding|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|negative regulation of cell differentiation|chaperone-mediated protein complex assembly" HORMAD1 83.38301198 76.12169763 90.64432632 1.190781724 0.251908984 0.737711099 1 1.798178845 2.233474375 84072 HORMA domain containing 1 "GO:0000795,GO:0001824,GO:0005515,GO:0005634,GO:0005694,GO:0007130,GO:0007283,GO:0042138,GO:0048477,GO:0051177,GO:0051321,GO:0051598,GO:0060629" synaptonemal complex|blastocyst development|protein binding|nucleus|chromosome|synaptonemal complex assembly|spermatogenesis|meiotic DNA double-strand break formation|oogenesis|meiotic sister chromatid cohesion|meiotic cell cycle|meiotic recombination checkpoint|regulation of homologous chromosome segregation HOXA1 103.1598076 114.6900244 91.62959074 0.798932524 -0.323854433 0.636481205 1 2.284170324 1.903507167 3198 homeobox A1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0007275,GO:0007605,GO:0007634,GO:0009653,GO:0021599,GO:0042473,GO:0042802,GO:0043565,GO:0045944,GO:0048702,GO:0048839,GO:0048844,GO:0050795,GO:0050890,GO:0050905,GO:0060840,GO:0060876,GO:0090102,GO:0090103,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|sensory perception of sound|optokinetic behavior|anatomical structure morphogenesis|abducens nerve formation|outer ear morphogenesis|identical protein binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|embryonic neurocranium morphogenesis|inner ear development|artery morphogenesis|regulation of behavior|cognition|neuromuscular process|artery development|semicircular canal formation|cochlea development|cochlea morphogenesis|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells Homeobox HOXA10 220.219959 202.9911937 237.4487244 1.169748894 0.226198865 0.669906147 1 4.045961373 4.9366269 3206 homeobox A10 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006357,GO:0007275,GO:0007283,GO:0007338,GO:0008584,GO:0009952,GO:0009954,GO:0030326,GO:0042826,GO:0045944,GO:0060065,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|single fertilization|male gonad development|anterior/posterior pattern specification|proximal/distal pattern formation|embryonic limb morphogenesis|histone deacetylase binding|positive regulation of transcription by RNA polymerase II|uterus development|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer HOXA13 81.27887116 66.98709391 95.57064841 1.426702411 0.512684442 0.484678559 1 0.676502491 1.006743246 3209 homeobox A13 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0001570,GO:0001886,GO:0001894,GO:0003281,GO:0003677,GO:0005654,GO:0005694,GO:0006357,GO:0030510,GO:0030539,GO:0035115,GO:0043565,GO:0045111,GO:0045840,GO:0045944,GO:0048839,GO:0048844,GO:0060442,GO:0060847,GO:1990837,GO:2001055" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|vasculogenesis|endothelial cell morphogenesis|tissue homeostasis|ventricular septum development|DNA binding|nucleoplasm|chromosome|regulation of transcription by RNA polymerase II|regulation of BMP signaling pathway|male genitalia development|embryonic forelimb morphogenesis|sequence-specific DNA binding|intermediate filament cytoskeleton|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|inner ear development|artery morphogenesis|branching involved in prostate gland morphogenesis|endothelial cell fate specification|sequence-specific double-stranded DNA binding|positive regulation of mesenchymal cell apoptotic process" Homeobox HOXA2 28.09216004 34.50850292 21.67581716 0.628129746 -0.670865504 0.516304019 1 1.036615619 0.679177106 3199 homeobox A2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001709,GO:0002076,GO:0005634,GO:0005654,GO:0006357,GO:0007379,GO:0008045,GO:0009952,GO:0009953,GO:0021568,GO:0021658,GO:0035284,GO:0042474,GO:0043231,GO:0045665,GO:0045668,GO:0045944,GO:0048703,GO:0071300,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cell fate determination|osteoblast development|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|segment specification|motor neuron axon guidance|anterior/posterior pattern specification|dorsal/ventral pattern formation|rhombomere 2 development|rhombomere 3 morphogenesis|brain segmentation|middle ear morphogenesis|intracellular membrane-bounded organelle|negative regulation of neuron differentiation|negative regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|embryonic viscerocranium morphogenesis|cellular response to retinoic acid|sequence-specific double-stranded DNA binding" HOXA3 272.4038384 267.9483757 276.859301 1.033256128 0.04719792 0.930664383 1 2.640716085 2.846070345 3200 homeobox A3 "GO:0000785,GO:0000978,GO:0000981,GO:0001525,GO:0001974,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008284,GO:0009952,GO:0010159,GO:0010467,GO:0021615,GO:0030878,GO:0048538,GO:0048645,GO:0048704,GO:0051216,GO:0060017,GO:0071837,GO:1900122" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|angiogenesis|blood vessel remodeling|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|anterior/posterior pattern specification|specification of animal organ position|gene expression|glossopharyngeal nerve morphogenesis|thyroid gland development|thymus development|animal organ formation|embryonic skeletal system morphogenesis|cartilage development|parathyroid gland development|HMG box domain binding|positive regulation of receptor binding" HOXA4 174.9895921 175.5873825 174.3918017 0.993190964 -0.009856959 0.997674007 1 5.271417599 5.461049482 3201 homeobox A4 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0009653,GO:0009952,GO:0016604,GO:0048704,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|anterior/posterior pattern specification|nuclear body|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" Homeobox HOXA5 161.5697563 167.4677348 155.6717778 0.929562808 -0.105375747 0.865119545 1 5.078832321 4.924459201 3202 homeobox A5 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003016,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0009952,GO:0010628,GO:0016477,GO:0016525,GO:0030878,GO:0033599,GO:0035264,GO:0043065,GO:0045639,GO:0045647,GO:0045944,GO:0048286,GO:0048704,GO:0060435,GO:0060441,GO:0060480,GO:0060484,GO:0060535,GO:0060574,GO:0060638,GO:0060644,GO:0060749,GO:0060764,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|respiratory system process|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|positive regulation of gene expression|cell migration|negative regulation of angiogenesis|thyroid gland development|regulation of mammary gland epithelial cell proliferation|multicellular organism growth|positive regulation of apoptotic process|positive regulation of myeloid cell differentiation|negative regulation of erythrocyte differentiation|positive regulation of transcription by RNA polymerase II|lung alveolus development|embryonic skeletal system morphogenesis|bronchiole development|epithelial tube branching involved in lung morphogenesis|lung goblet cell differentiation|lung-associated mesenchyme development|trachea cartilage morphogenesis|intestinal epithelial cell maturation|mesenchymal-epithelial cell signaling|mammary gland epithelial cell differentiation|mammary gland alveolus development|cell-cell signaling involved in mammary gland development|sequence-specific double-stranded DNA binding" Homeobox HOXA6 14.55355801 18.26920743 10.83790858 0.593233649 -0.753327664 0.562628766 1 0.935562089 0.578914359 3203 homeobox A6 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0006357,GO:0009952,GO:0016607,GO:0048704,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|nuclear speck|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" Homeobox HOXA9 11.95678498 9.134603715 14.77896625 1.617909951 0.694131313 0.630281003 1 0.224145084 0.378267905 3205 homeobox A9 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006351,GO:0006357,GO:0007275,GO:0007283,GO:0007338,GO:0008584,GO:0009952,GO:0009954,GO:0019899,GO:0030879,GO:0035115,GO:0042118,GO:0045638,GO:0045944,GO:0048704,GO:0060065,GO:0060216,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|single fertilization|male gonad development|anterior/posterior pattern specification|proximal/distal pattern formation|enzyme binding|mammary gland development|embryonic forelimb morphogenesis|endothelial cell activation|negative regulation of myeloid cell differentiation|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|uterus development|definitive hemopoiesis|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer Homeobox HOXB13 328.1400636 340.0102494 316.2698777 0.930177482 -0.104422079 0.825938125 1 5.666442793 5.49784207 10481 homeobox B13 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001525,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0008327,GO:0008544,GO:0009611,GO:0033574,GO:0040008,GO:0043565,GO:0060527,GO:0060743,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|angiogenesis|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|methyl-CpG binding|epidermis development|response to wounding|response to testosterone|regulation of growth|sequence-specific DNA binding|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|epithelial cell maturation involved in prostate gland development|sequence-specific double-stranded DNA binding" Homeobox HOXB2 556.9953131 459.7750537 654.2155726 1.422903586 0.50883791 0.201190453 1 13.21565521 19.61462923 3212 homeobox B2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002011,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007275,GO:0008015,GO:0009952,GO:0009953,GO:0021569,GO:0021570,GO:0021612,GO:0043565,GO:0045944,GO:0048704,GO:0048857,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|morphogenesis of an epithelial sheet|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|blood circulation|anterior/posterior pattern specification|dorsal/ventral pattern formation|rhombomere 3 development|rhombomere 4 development|facial nerve structural organization|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|neural nucleus development|sequence-specific double-stranded DNA binding" HOXB3 729.0412362 669.8709391 788.2115332 1.176661782 0.234699694 0.531922317 1 3.873783958 4.754479443 3213 homeobox B3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0002244,GO:0005634,GO:0005654,GO:0006357,GO:0009952,GO:0021546,GO:0021615,GO:0030878,GO:0045944,GO:0048704,GO:0050767,GO:0051216,GO:0060216,GO:0060324" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|hematopoietic progenitor cell differentiation|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|rhombomere development|glossopharyngeal nerve morphogenesis|thyroid gland development|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|regulation of neurogenesis|cartilage development|definitive hemopoiesis|face development" HOXB4 519.2056476 536.9117073 501.499588 0.9340448 -0.098436347 0.811710348 1 13.58275917 13.23340601 3214 homeobox B4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0002011,GO:0005634,GO:0005654,GO:0005813,GO:0006357,GO:0008283,GO:0009952,GO:0045944,GO:0048103,GO:0048536,GO:0048539,GO:0048704,GO:0060216,GO:0060218,GO:1990837,GO:2000738" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|morphogenesis of an epithelial sheet|nucleus|nucleoplasm|centrosome|regulation of transcription by RNA polymerase II|cell population proliferation|anterior/posterior pattern specification|positive regulation of transcription by RNA polymerase II|somatic stem cell division|spleen development|bone marrow development|embryonic skeletal system morphogenesis|definitive hemopoiesis|hematopoietic stem cell differentiation|sequence-specific double-stranded DNA binding|positive regulation of stem cell differentiation" Homeobox HOXB5 124.046077 94.39090506 153.701249 1.62834808 0.703409127 0.265999017 1 2.571579532 4.367803947 3215 homeobox B5 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0009653,GO:0009952,GO:0045446,GO:0045944,GO:0048704,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|anterior/posterior pattern specification|endothelial cell differentiation|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXB6 441.4575956 374.5187523 508.3964389 1.35746591 0.440915968 0.29650746 1 8.532637689 12.08170332 3216 homeobox B6 "GO:0000785,GO:0000978,GO:0000981,GO:0003723,GO:0005515,GO:0005634,GO:0006357,GO:0009952,GO:0034101,GO:0048704,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|erythrocyte homeostasis|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXB7 455.9463273 455.7152298 456.1774249 1.001014219 0.001462467 1 1 16.93350603 17.68084688 3217 homeobox B7 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0007275,GO:0009952,GO:0016604,GO:0030099,GO:0045944,GO:0048704,GO:0090190,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|anterior/posterior pattern specification|nuclear body|myeloid cell differentiation|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis|sequence-specific double-stranded DNA binding" Homeobox HOXB8 100.3700395 92.36099312 108.3790858 1.173429195 0.230730792 0.743436674 1 1.13262917 1.386310656 3218 homeobox B8 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0005654,GO:0006357,GO:0007625,GO:0008344,GO:0009952,GO:0019233,GO:0021516,GO:0045638,GO:0048704,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|grooming behavior|adult locomotory behavior|anterior/posterior pattern specification|sensory perception of pain|dorsal spinal cord development|negative regulation of myeloid cell differentiation|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXB9 532.1773886 548.0762229 516.2785543 0.941983127 -0.086226877 0.834269063 1 10.73400124 10.54679961 3219 homeobox B9 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0009952,GO:0009954,GO:0030879,GO:0045944,GO:0048704,GO:0060326,GO:0090575,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|proximal/distal pattern formation|mammary gland development|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|cell chemotaxis|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" HOXC10 56.96174364 54.80762229 59.11586499 1.078606634 0.109168812 0.914946174 1 1.404763522 1.580455376 3226 homeobox C10 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008284,GO:0009952,GO:0009954,GO:0016604,GO:0021520,GO:0030326,GO:0045944,GO:0050905,GO:0120163,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|anterior/posterior pattern specification|proximal/distal pattern formation|nuclear body|spinal cord motor neuron cell fate specification|embryonic limb morphogenesis|positive regulation of transcription by RNA polymerase II|neuromuscular process|negative regulation of cold-induced thermogenesis|sequence-specific double-stranded DNA binding" HOXC13 94.95108518 92.36099312 97.54117724 1.056086276 0.078727699 0.924696518 1 1.984623874 2.186218374 3229 homeobox C13 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001942,GO:0003682,GO:0005515,GO:0005634,GO:0006357,GO:0009653,GO:0009952,GO:0035878,GO:0043587,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|hair follicle development|chromatin binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|anterior/posterior pattern specification|nail development|tongue morphogenesis|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" HOXC4 300.4420585 231.4099608 369.4741562 1.596621662 0.67502249 0.153719344 1 4.983034927 8.298734647 3221 homeobox C4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0009952,GO:0045944,GO:0048704,GO:0051216,GO:0071837,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|cartilage development|HMG box domain binding|sequence-specific double-stranded DNA binding" HOXC5 86.60602919 94.39090506 78.82115332 0.835050297 -0.260064997 0.725091398 1 2.967452731 2.584713282 3222 homeobox C5 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0009952,GO:0030054" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|cell junction" HOXC6 341.6989546 290.277407 393.1205022 1.354292455 0.437539318 0.336076061 1 6.750012225 9.535268971 3223 homeobox C6 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007275,GO:0009952,GO:0048706" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|multicellular organism development|anterior/posterior pattern specification|embryonic skeletal system development" Homeobox HOXC8 210.1297825 186.7518982 233.5076667 1.250363016 0.322347012 0.546610733 1 3.913249823 5.103752709 3224 homeobox C8 "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007275,GO:0015630,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|microtubule cytoskeleton|sequence-specific double-stranded DNA binding" Homeobox HOXC9 244.400753 239.5296085 249.2718974 1.040672587 0.057516244 0.917499396 1 8.230210083 8.933897502 3225 homeobox C9 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0009952,GO:0009954,GO:0016235,GO:0048704,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|proximal/distal pattern formation|aggresome|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXD1 80.86046783 72.06187375 89.65906191 1.24419554 0.315213239 0.674319467 1 1.935142994 2.511410073 3231 homeobox D1 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0006357,GO:0019233,GO:0030182,GO:0048706,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|sensory perception of pain|neuron differentiation|embryonic skeletal system development|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells HOXD10 130.3733452 122.8096722 137.9370183 1.123177156 0.167585498 0.796910904 1 3.484524733 4.082326565 3236 homeobox D10 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007338,GO:0007519,GO:0008344,GO:0009952,GO:0009954,GO:0021520,GO:0030326,GO:0035136,GO:0035137,GO:0036464,GO:0045944,GO:0048704,GO:0048935,GO:0050905,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|single fertilization|skeletal muscle tissue development|adult locomotory behavior|anterior/posterior pattern specification|proximal/distal pattern formation|spinal cord motor neuron cell fate specification|embryonic limb morphogenesis|forelimb morphogenesis|hindlimb morphogenesis|cytoplasmic ribonucleoprotein granule|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|peripheral nervous system neuron development|neuromuscular process|sequence-specific double-stranded DNA binding" "hsa05205,hsa05206" Proteoglycans in cancer|MicroRNAs in cancer HOXD11 206.441103 204.0061496 208.8760563 1.023871372 0.034034482 0.958957376 1 6.059936533 6.471864344 3237 homeobox D11 "GO:0000785,GO:0000978,GO:0000981,GO:0001658,GO:0005634,GO:0005654,GO:0006357,GO:0009953,GO:0048856,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|branching involved in ureteric bud morphogenesis|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|dorsal/ventral pattern formation|anatomical structure development|sequence-specific double-stranded DNA binding" HOXD12 7.463712004 5.074779842 9.852644165 1.941491941 0.957165719 0.581982097 1 0.10083158 0.204196405 3238 homeobox D12 "GO:0000785,GO:0000981,GO:0001501,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007389,GO:0042733,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|skeletal system development|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|pattern specification process|embryonic digit morphogenesis|sequence-specific double-stranded DNA binding" HOXD13 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.031918 0.008079737 3239 homeobox D13 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0003677,GO:0003682,GO:0003700,GO:0005654,GO:0006355,GO:0006357,GO:0007275,GO:0009952,GO:0030539,GO:0033574,GO:0042127,GO:0042733,GO:0045944,GO:0048619,GO:0060527,GO:0060571,GO:0060602,GO:0060687,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|DNA binding|chromatin binding|DNA-binding transcription factor activity|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|anterior/posterior pattern specification|male genitalia development|response to testosterone|regulation of cell population proliferation|embryonic digit morphogenesis|positive regulation of transcription by RNA polymerase II|embryonic hindgut morphogenesis|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|morphogenesis of an epithelial fold|branch elongation of an epithelium|regulation of branching involved in prostate gland morphogenesis|sequence-specific double-stranded DNA binding" HOXD3 97.56270398 102.5105528 92.61485516 0.903466547 -0.146456912 0.843369196 1 0.925289229 0.87197797 3232 homeobox D3 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0007160,GO:0007219,GO:0009952,GO:0010628,GO:0016235,GO:0016604,GO:0021615,GO:0030878,GO:0045666,GO:0045944,GO:0048704,GO:0051216,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell-matrix adhesion|Notch signaling pathway|anterior/posterior pattern specification|positive regulation of gene expression|aggresome|nuclear body|glossopharyngeal nerve morphogenesis|thyroid gland development|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|cartilage development|sequence-specific double-stranded DNA binding" HOXD4 553.3808625 482.104085 624.6576401 1.295690411 0.373721046 0.348832224 1 4.746670129 6.415141289 3233 homeobox D4 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007275,GO:0009952,GO:0030054,GO:0045944,GO:0048704,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|anterior/posterior pattern specification|cell junction|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXD8 92.20313279 106.5703767 77.83588891 0.730370778 -0.453299051 0.51992413 1 3.379720489 2.574779858 3234 homeobox D8 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0008595,GO:0045944,GO:0048705,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior axis specification, embryo|positive regulation of transcription by RNA polymerase II|skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXD9 151.9870577 152.2433953 151.7307201 0.99663253 -0.004866431 1 1 4.121106834 4.284151903 3235 homeobox D9 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006357,GO:0007338,GO:0007519,GO:0008344,GO:0009952,GO:0009954,GO:0030879,GO:0035115,GO:0035137,GO:0045944,GO:0048704,GO:0048935,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription by RNA polymerase II|single fertilization|skeletal muscle tissue development|adult locomotory behavior|anterior/posterior pattern specification|proximal/distal pattern formation|mammary gland development|embryonic forelimb morphogenesis|hindlimb morphogenesis|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|peripheral nervous system neuron development|sequence-specific double-stranded DNA binding" HP1BP3 3958.900812 3442.730645 4475.07098 1.299860907 0.378357255 0.235366391 1 21.15532176 28.68352009 50809 heterochromatin protein 1 binding protein 3 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0005694,GO:0006334,GO:0006355,GO:0016607,GO:0031491,GO:0042127,GO:0070828,GO:0071456,GO:0097298" "nucleosome|DNA binding|protein binding|nucleus|chromosome|nucleosome assembly|regulation of transcription, DNA-templated|nuclear speck|nucleosome binding|regulation of cell population proliferation|heterochromatin organization|cellular response to hypoxia|regulation of nucleus size" HPCA 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.074969284 0 3208 hippocalcin "GO:0003779,GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0007420,GO:0019722,GO:0019898,GO:0019900,GO:0030424,GO:0031283,GO:0031584,GO:0032590,GO:0032809,GO:0032839,GO:0042802,GO:0043204,GO:0044327,GO:0045762,GO:0048839,GO:0060041,GO:0071257,GO:0071277,GO:0090314,GO:0098978,GO:0099149,GO:1901385,GO:1901986,GO:1902065,GO:1904009,GO:1904010" actin binding|calcium ion binding|protein binding|cytoplasm|cytosol|brain development|calcium-mediated signaling|extrinsic component of membrane|kinase binding|axon|negative regulation of guanylate cyclase activity|activation of phospholipase D activity|dendrite membrane|neuronal cell body membrane|dendrite cytoplasm|identical protein binding|perikaryon|dendritic spine head|positive regulation of adenylate cyclase activity|inner ear development|retina development in camera-type eye|cellular response to electrical stimulus|cellular response to calcium ion|positive regulation of protein targeting to membrane|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|regulation of voltage-gated calcium channel activity|response to ketamine|response to L-glutamate|cellular response to monosodium glutamate|response to Aroclor 1254 HPCAL1 3638.796027 4157.259646 3120.332407 0.750574338 -0.413933129 0.193696952 1 39.52516147 30.94448751 3241 hippocalcin like 1 "GO:0005509,GO:0005515,GO:0016020" calcium ion binding|protein binding|membrane HPCAL4 4.463381426 2.029911937 6.896850916 3.397610897 1.764520641 0.414871268 1 0.021762887 0.077126936 51440 hippocalcin like 4 "GO:0005246,GO:0005509,GO:0005515,GO:0007165,GO:0007417,GO:0008022,GO:0019904" calcium channel regulator activity|calcium ion binding|protein binding|signal transduction|central nervous system development|protein C-terminus binding|protein domain specific binding HPF1 244.967614 244.6043884 245.3308397 1.002969903 0.004278315 1 1 10.1877873 10.65819594 54969 histone PARylation factor 1 "GO:0005515,GO:0005634,GO:0006974,GO:0008270,GO:0010835,GO:0018312,GO:0042393,GO:0072572" protein binding|nucleus|cellular response to DNA damage stimulus|zinc ion binding|regulation of protein ADP-ribosylation|peptidyl-serine ADP-ribosylation|histone binding|poly-ADP-D-ribose binding HPGD 6.522984915 8.119647747 4.926322083 0.606716232 -0.720906186 0.726457076 1 0.094972636 0.060103538 3248 15-hydroxyprostaglandin dehydrogenase "GO:0001822,GO:0004957,GO:0005654,GO:0005737,GO:0005829,GO:0006693,GO:0007179,GO:0007565,GO:0007567,GO:0016323,GO:0016404,GO:0016616,GO:0019372,GO:0030728,GO:0032355,GO:0032496,GO:0042759,GO:0042802,GO:0043065,GO:0045471,GO:0045786,GO:0051287,GO:0055114,GO:0070062,GO:0070403,GO:0070493,GO:0097070,GO:1904707,GO:1905828,GO:2001301" "kidney development|prostaglandin E receptor activity|nucleoplasm|cytoplasm|cytosol|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway|female pregnancy|parturition|basolateral plasma membrane|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|lipoxygenase pathway|ovulation|response to estradiol|response to lipopolysaccharide|long-chain fatty acid biosynthetic process|identical protein binding|positive regulation of apoptotic process|response to ethanol|negative regulation of cell cycle|NAD binding|oxidation-reduction process|extracellular exosome|NAD+ binding|thrombin-activated receptor signaling pathway|ductus arteriosus closure|positive regulation of vascular associated smooth muscle cell proliferation|regulation of prostaglandin catabolic process|lipoxin biosynthetic process" hsa05202 Transcriptional misregulation in cancer HPRT1 1480.299418 1477.77589 1482.822947 1.003415306 0.00491885 0.990488119 1 53.65171007 56.15393826 3251 hypoxanthine phosphoribosyltransferase 1 "GO:0000166,GO:0000287,GO:0001913,GO:0001975,GO:0004422,GO:0005515,GO:0005737,GO:0005829,GO:0006164,GO:0006166,GO:0006168,GO:0006178,GO:0007625,GO:0007626,GO:0021756,GO:0021895,GO:0021954,GO:0032263,GO:0032264,GO:0042417,GO:0042802,GO:0043101,GO:0043103,GO:0045964,GO:0046038,GO:0046040,GO:0046100,GO:0046651,GO:0048813,GO:0051289,GO:0052657,GO:0070062" nucleotide binding|magnesium ion binding|T cell mediated cytotoxicity|response to amphetamine|hypoxanthine phosphoribosyltransferase activity|protein binding|cytoplasm|cytosol|purine nucleotide biosynthetic process|purine ribonucleoside salvage|adenine salvage|guanine salvage|grooming behavior|locomotory behavior|striatum development|cerebral cortex neuron differentiation|central nervous system neuron development|GMP salvage|IMP salvage|dopamine metabolic process|identical protein binding|purine-containing compound salvage|hypoxanthine salvage|positive regulation of dopamine metabolic process|GMP catabolic process|IMP metabolic process|hypoxanthine metabolic process|lymphocyte proliferation|dendrite morphogenesis|protein homotetramerization|guanine phosphoribosyltransferase activity|extracellular exosome "hsa00230,hsa00983" Purine metabolism|Drug metabolism - other enzymes HPS1 1570.69681 1393.534545 1747.859075 1.254263184 0.326840103 0.321667091 1 16.41339735 21.47351242 3257 HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 "GO:0005085,GO:0005515,GO:0005737,GO:0005764,GO:0005829,GO:0007040,GO:0007601,GO:0016192,GO:0031085,GO:0031410,GO:0046983,GO:0050790,GO:0050896,GO:1903232" guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|lysosome|cytosol|lysosome organization|visual perception|vesicle-mediated transport|BLOC-3 complex|cytoplasmic vesicle|protein dimerization activity|regulation of catalytic activity|response to stimulus|melanosome assembly HPS3 1050.50293 1260.575313 840.4305473 0.666703956 -0.584881808 0.094552052 1 12.33217936 8.576079417 84343 HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 "GO:0005515,GO:0005737,GO:0006996,GO:0031084,GO:0043473" protein binding|cytoplasm|organelle organization|BLOC-2 complex|pigmentation HPS4 1052.074107 1031.195264 1072.95295 1.040494451 0.057269271 0.872261017 1 6.366744152 6.909921221 89781 HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 "GO:0005085,GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0006605,GO:0007040,GO:0007596,GO:0007599,GO:0016020,GO:0016192,GO:0030318,GO:0031085,GO:0031267,GO:0031410,GO:0042470,GO:0042803,GO:0042827,GO:0046983,GO:0048075,GO:0050790,GO:0050821,GO:1903232,GO:1903955" guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|lysosome|lysosomal membrane|cytosol|protein targeting|lysosome organization|blood coagulation|hemostasis|membrane|vesicle-mediated transport|melanocyte differentiation|BLOC-3 complex|small GTPase binding|cytoplasmic vesicle|melanosome|protein homodimerization activity|platelet dense granule|protein dimerization activity|positive regulation of eye pigmentation|regulation of catalytic activity|protein stabilization|melanosome assembly|positive regulation of protein targeting to mitochondrion HPS5 684.07265 727.7234293 640.4218708 0.880034701 -0.184367682 0.628957797 1 6.904575579 6.338007008 11234 HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 "GO:0005515,GO:0005829,GO:0006996,GO:0007596,GO:0031084,GO:0043473" protein binding|cytosol|organelle organization|blood coagulation|BLOC-2 complex|pigmentation HPS6 1405.243895 1432.102871 1378.384919 0.962490158 -0.055156307 0.870873179 1 26.98324341 27.08983613 79803 HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 "GO:0005515,GO:0005765,GO:0005783,GO:0006996,GO:0007596,GO:0016020,GO:0030318,GO:0030742,GO:0031084,GO:0031267,GO:0031901,GO:0032418,GO:0072657" protein binding|lysosomal membrane|endoplasmic reticulum|organelle organization|blood coagulation|membrane|melanocyte differentiation|GTP-dependent protein binding|BLOC-2 complex|small GTPase binding|early endosome membrane|lysosome localization|protein localization to membrane HPSE 72.18880477 51.76275439 92.61485516 1.789218063 0.839329228 0.267712033 1 0.563542756 1.051734391 10855 heparanase "GO:0004566,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005764,GO:0005765,GO:0006027,GO:0006029,GO:0007160,GO:0010575,GO:0030194,GO:0030200,GO:0030305,GO:0031012,GO:0033690,GO:0035580,GO:0043202,GO:0043231,GO:0043312,GO:0045121,GO:0045545,GO:0051797,GO:0051798,GO:0051897,GO:0060055,GO:0061042" beta-glucuronidase activity|protein binding|extracellular region|nucleus|nucleoplasm|lysosome|lysosomal membrane|glycosaminoglycan catabolic process|proteoglycan metabolic process|cell-matrix adhesion|positive regulation of vascular endothelial growth factor production|positive regulation of blood coagulation|heparan sulfate proteoglycan catabolic process|heparanase activity|extracellular matrix|positive regulation of osteoblast proliferation|specific granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|membrane raft|syndecan binding|regulation of hair follicle development|positive regulation of hair follicle development|positive regulation of protein kinase B signaling|angiogenesis involved in wound healing|vascular wound healing "hsa00531,hsa05205" Glycosaminoglycan degradation|Proteoglycans in cancer HR 20.0318954 22.3290313 17.7347595 0.794246703 -0.332340898 0.800682888 1 0.2145895 0.177778738 55806 HR lysine demethylase and nuclear receptor corepressor "GO:0000118,GO:0000785,GO:0003712,GO:0005515,GO:0005654,GO:0006357,GO:0016491,GO:0031490,GO:0032454,GO:0033169,GO:0046872,GO:0055114" histone deacetylase complex|chromatin|transcription coregulator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|oxidoreductase activity|chromatin DNA binding|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|metal ion binding|oxidation-reduction process HRAS 2201.283112 2101.973811 2300.592413 1.094491473 0.130260715 0.685056711 1 84.49012554 96.45711489 3265 "HRas proto-oncogene, GTPase" "GO:0000139,GO:0000165,GO:0001889,GO:0001934,GO:0002223,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006897,GO:0006935,GO:0007050,GO:0007165,GO:0007166,GO:0007265,GO:0008022,GO:0008284,GO:0008285,GO:0009887,GO:0010629,GO:0010863,GO:0019003,GO:0030335,GO:0032729,GO:0034260,GO:0035900,GO:0042088,GO:0042832,GO:0043406,GO:0043410,GO:0043524,GO:0043547,GO:0044877,GO:0045740,GO:0045944,GO:0046330,GO:0046579,GO:0048013,GO:0048169,GO:0048471,GO:0050679,GO:0050852,GO:0070374,GO:0071480,GO:0090303,GO:0090314,GO:0090398,GO:0097193,GO:0098696,GO:0098978,GO:1900029,GO:2000251,GO:2000630" Golgi membrane|MAPK cascade|liver development|positive regulation of protein phosphorylation|stimulatory C-type lectin receptor signaling pathway|GTPase activity|protein binding|GTP binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|endocytosis|chemotaxis|cell cycle arrest|signal transduction|cell surface receptor signaling pathway|Ras protein signal transduction|protein C-terminus binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|animal organ morphogenesis|negative regulation of gene expression|positive regulation of phospholipase C activity|GDP binding|positive regulation of cell migration|positive regulation of interferon-gamma production|negative regulation of GTPase activity|response to isolation stress|T-helper 1 type immune response|defense response to protozoan|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|protein-containing complex binding|positive regulation of DNA replication|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of Ras protein signal transduction|ephrin receptor signaling pathway|regulation of long-term neuronal synaptic plasticity|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|T cell receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to gamma radiation|positive regulation of wound healing|positive regulation of protein targeting to membrane|cellular senescence|intrinsic apoptotic signaling pathway|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|glutamatergic synapse|positive regulation of ruffle assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of miRNA metabolic process "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04062,hsa04068,hsa04071,hsa04072,hsa04137,hsa04140,hsa04144,hsa04150,hsa04151,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04371,hsa04510,hsa04540,hsa04550,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04929,hsa04933,hsa04935,hsa05010,hsa05022,hsa05034,hsa05132,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Endocytosis|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Salmonella infection|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" HRCT1 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.10995495 0.222672358 646962 histidine rich carboxyl terminus 1 GO:0016021 integral component of membrane HRH1 680.3245875 740.9178569 619.731318 0.836437281 -0.257670728 0.498751746 1 7.967064894 6.951006045 3269 histamine receptor H1 "GO:0004930,GO:0004969,GO:0004993,GO:0005829,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007187,GO:0007200,GO:0007268,GO:0007613,GO:0008542,GO:0030425,GO:0030594,GO:0032962,GO:0043114,GO:0045202,GO:0045907,GO:0048016,GO:0048167,GO:0048245,GO:0071420,GO:0098664" "G protein-coupled receptor activity|histamine receptor activity|G protein-coupled serotonin receptor activity|cytosol|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|phospholipase C-activating G protein-coupled receptor signaling pathway|chemical synaptic transmission|memory|visual learning|dendrite|neurotransmitter receptor activity|positive regulation of inositol trisphosphate biosynthetic process|regulation of vascular permeability|synapse|positive regulation of vasoconstriction|inositol phosphate-mediated signaling|regulation of synaptic plasticity|eosinophil chemotaxis|cellular response to histamine|G protein-coupled serotonin receptor signaling pathway" "hsa04020,hsa04080,hsa04750" Calcium signaling pathway|Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels HRK 4.493072978 4.059823873 4.926322083 1.213432463 0.279093814 1 1 0.033801703 0.04278289 8739 "harakiri, BCL2 interacting protein" "GO:0005515,GO:0005739,GO:0006915,GO:0016021,GO:0031334,GO:0043065,GO:0090200" protein binding|mitochondrion|apoptotic process|integral component of membrane|positive regulation of protein-containing complex assembly|positive regulation of apoptotic process|positive regulation of release of cytochrome c from mitochondria hsa04210 Apoptosis HROB 326.4273561 290.277407 362.5773053 1.249071738 0.320856338 0.487857226 1 4.370251672 5.693899002 78995 homologous recombination factor with OB-fold "GO:0000725,GO:0000731,GO:0003697,GO:0005515,GO:0005634,GO:0006974,GO:0007292,GO:0036297,GO:0048232,GO:0090734" recombinational repair|DNA synthesis involved in DNA repair|single-stranded DNA binding|protein binding|nucleus|cellular response to DNA damage stimulus|female gamete generation|interstrand cross-link repair|male gamete generation|site of DNA damage HS1BP3 426.7474151 446.5806261 406.914204 0.911177468 -0.134196023 0.756599109 1 2.779615739 2.641822676 64342 HCLS1 binding protein 3 "GO:0005515,GO:0005739,GO:0005783,GO:0035091,GO:0042981" protein binding|mitochondrion|endoplasmic reticulum|phosphatidylinositol binding|regulation of apoptotic process HS2ST1 1099.6892 1288.99408 910.3843209 0.706275021 -0.501698021 0.148245178 1 8.981015662 6.616300628 9653 heparan sulfate 2-O-sulfotransferase 1 "GO:0000139,GO:0004394,GO:0006024,GO:0008146,GO:0015014,GO:0015015,GO:0016020,GO:0016021" "Golgi membrane|heparan sulfate 2-O-sulfotransferase activity|glycosaminoglycan biosynthetic process|sulfotransferase activity|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|membrane|integral component of membrane" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS3ST1 27.13658718 36.53841486 17.7347595 0.485372985 -1.042834281 0.309324794 1 0.152508803 0.077212292 9957 heparan sulfate-glucosamine 3-sulfotransferase 1 "GO:0005796,GO:0006024,GO:0008146,GO:0008467" Golgi lumen|glycosaminoglycan biosynthetic process|sulfotransferase activity|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS6ST1 242.1602786 254.7539481 229.5666091 0.901130722 -0.150191691 0.77288935 1 3.055266103 2.871790586 9394 heparan sulfate 6-O-sulfotransferase 1 "GO:0000139,GO:0005515,GO:0005887,GO:0006024,GO:0008146,GO:0015015,GO:0017095,GO:0048666" "Golgi membrane|protein binding|integral component of plasma membrane|glycosaminoglycan biosynthetic process|sulfotransferase activity|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|heparan sulfate 6-O-sulfotransferase activity|neuron development" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS6ST3 12.07555119 17.25425146 6.896850916 0.399718929 -1.3229422 0.32338084 1 0.038833354 0.01619107 266722 heparan sulfate 6-O-sulfotransferase 3 "GO:0015015,GO:0016021,GO:0017095" "heparan sulfate proteoglycan biosynthetic process, enzymatic modification|integral component of membrane|heparan sulfate 6-O-sulfotransferase activity" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HSBP1 1616.659817 1774.143033 1459.176601 0.822468411 -0.281967825 0.391044387 1 10.38895662 8.912654868 3281 heat shock factor binding protein 1 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005856,GO:0006936,GO:0035987,GO:0042802,GO:0070370,GO:1900034" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|cytoskeleton|muscle contraction|endodermal cell differentiation|identical protein binding|cellular heat acclimation|regulation of cellular response to heat HSBP1L1 324.8455391 283.1727152 366.518363 1.294327961 0.372203218 0.420989967 1 20.8152381 28.10228578 440498 heat shock factor binding protein 1 like 1 "GO:0003714,GO:0005515,GO:0005634,GO:0005829,GO:0045892,GO:0070370" "transcription corepressor activity|protein binding|nucleus|cytosol|negative regulation of transcription, DNA-templated|cellular heat acclimation" HSCB 171.9892616 172.5425146 171.4360085 0.993587052 -0.009281722 0.998717525 1 6.875428538 7.125603057 150274 HscB mitochondrial iron-sulfur cluster cochaperone "GO:0001671,GO:0003674,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0016226,GO:0032781,GO:0042802,GO:0044571,GO:0046872,GO:0051087,GO:0051259,GO:0097428" ATPase activator activity|molecular_function|protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|iron-sulfur cluster assembly|positive regulation of ATPase activity|identical protein binding|[2Fe-2S] cluster assembly|metal ion binding|chaperone binding|protein complex oligomerization|protein maturation by iron-sulfur cluster transfer HSD11B1 4.552456082 8.119647747 0.985264417 0.121343246 -3.042834281 0.175274214 1 0.275809198 0.034909231 3290 hydroxysteroid 11-beta dehydrogenase 1 "GO:0003845,GO:0005496,GO:0005789,GO:0006704,GO:0006706,GO:0016020,GO:0030176,GO:0030324,GO:0042803,GO:0050661,GO:0055114,GO:0070524" 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity|steroid binding|endoplasmic reticulum membrane|glucocorticoid biosynthetic process|steroid catabolic process|membrane|integral component of endoplasmic reticulum membrane|lung development|protein homodimerization activity|NADP binding|oxidation-reduction process|11-beta-hydroxysteroid dehydrogenase (NADP+) activity "hsa00140,hsa00980,hsa05204" Steroid hormone biosynthesis|Metabolism of xenobiotics by cytochrome P450|Chemical carcinogenesis HSD11B1L 66.09634736 73.07682972 59.11586499 0.808954975 -0.305868687 0.705640295 1 1.990900283 1.679924595 374875 hydroxysteroid 11-beta dehydrogenase 1 like "GO:0005576,GO:0005654,GO:0016491,GO:0043231,GO:0055114" extracellular region|nucleoplasm|oxidoreductase activity|intracellular membrane-bounded organelle|oxidation-reduction process "hsa00140,hsa00980,hsa05204" Steroid hormone biosynthesis|Metabolism of xenobiotics by cytochrome P450|Chemical carcinogenesis HSD17B1 56.02101655 57.8524902 54.18954291 0.936684708 -0.094364582 0.930631061 1 2.294459309 2.24176312 3292 hydroxysteroid 17-beta dehydrogenase 1 "GO:0003824,GO:0004303,GO:0005496,GO:0005515,GO:0005737,GO:0005829,GO:0006694,GO:0006703,GO:0008210,GO:0030283,GO:0035410,GO:0042803,GO:0050661,GO:0055114,GO:0061370,GO:0070401,GO:0072582,GO:1903924" catalytic activity|estradiol 17-beta-dehydrogenase activity|steroid binding|protein binding|cytoplasm|cytosol|steroid biosynthetic process|estrogen biosynthetic process|estrogen metabolic process|testosterone dehydrogenase [NAD(P)] activity|dihydrotestosterone 17-beta-dehydrogenase activity|protein homodimerization activity|NADP binding|oxidation-reduction process|testosterone biosynthetic process|NADP+ binding|17-beta-hydroxysteroid dehydrogenase (NADP+) activity|estradiol binding "hsa00140,hsa04913" Steroid hormone biosynthesis|Ovarian steroidogenesis HSD17B10 1490.197838 1649.303449 1331.092227 0.807063265 -0.309246325 0.351474826 1 87.28464083 73.47867886 3028 hydroxysteroid 17-beta dehydrogenase 10 "GO:0000049,GO:0003723,GO:0003857,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005886,GO:0006550,GO:0006629,GO:0006635,GO:0006699,GO:0007005,GO:0008207,GO:0008209,GO:0008210,GO:0008709,GO:0009083,GO:0030283,GO:0030678,GO:0042645,GO:0044594,GO:0047015,GO:0047035,GO:0047044,GO:0051289,GO:0062173,GO:0070901,GO:0090646,GO:0097745,GO:0106281,GO:0106282,GO:0106283,GO:1990180" "tRNA binding|RNA binding|3-hydroxyacyl-CoA dehydrogenase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|plasma membrane|isoleucine catabolic process|lipid metabolic process|fatty acid beta-oxidation|bile acid biosynthetic process|mitochondrion organization|C21-steroid hormone metabolic process|androgen metabolic process|estrogen metabolic process|cholate 7-alpha-dehydrogenase activity|branched-chain amino acid catabolic process|testosterone dehydrogenase [NAD(P)] activity|mitochondrial ribonuclease P complex|mitochondrial nucleoid|17-beta-hydroxysteroid dehydrogenase (NAD+) activity|3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity|testosterone dehydrogenase (NAD+) activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|protein homotetramerization|brexanolone metabolic process|mitochondrial tRNA methylation|mitochondrial tRNA processing|mitochondrial tRNA 5'-end processing|chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity|isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity|ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity|mitochondrial tRNA 3'-end processing" "hsa00280,hsa05010,hsa05022" "Valine, leucine and isoleucine degradation|Alzheimer disease|Pathways of neurodegeneration - multiple diseases" HSD17B11 708.4776145 577.509946 839.4452829 1.453559871 0.539590497 0.15232311 1 15.66622466 23.75271209 51170 hydroxysteroid 17-beta dehydrogenase 11 "GO:0004303,GO:0005515,GO:0005737,GO:0005783,GO:0005811,GO:0005829,GO:0006703,GO:0006710,GO:0016229,GO:0016616,GO:0055114" "estradiol 17-beta-dehydrogenase activity|protein binding|cytoplasm|endoplasmic reticulum|lipid droplet|cytosol|estrogen biosynthetic process|androgen catabolic process|steroid dehydrogenase activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|oxidation-reduction process" HSD17B12 2476.042231 2227.828351 2724.256112 1.222830346 0.290224259 0.363254627 1 32.76180216 41.78783976 51144 hydroxysteroid 17-beta dehydrogenase 12 "GO:0001968,GO:0004303,GO:0005515,GO:0005518,GO:0005789,GO:0006633,GO:0006703,GO:0008201,GO:0009923,GO:0010811,GO:0016021,GO:0030198,GO:0031012,GO:0035338,GO:0050062,GO:0055114,GO:0102339,GO:0102340,GO:0102341,GO:0102342" fibronectin binding|estradiol 17-beta-dehydrogenase activity|protein binding|collagen binding|endoplasmic reticulum membrane|fatty acid biosynthetic process|estrogen biosynthetic process|heparin binding|fatty acid elongase complex|positive regulation of cell-substrate adhesion|integral component of membrane|extracellular matrix organization|extracellular matrix|long-chain fatty-acyl-CoA biosynthetic process|long-chain-fatty-acyl-CoA reductase activity|oxidation-reduction process|3-oxo-arachidoyl-CoA reductase activity|3-oxo-behenoyl-CoA reductase activity|3-oxo-lignoceroyl-CoA reductase activity|3-oxo-cerotoyl-CoA reductase activity "hsa00062,hsa00140,hsa01040" Fatty acid elongation|Steroid hormone biosynthesis|Biosynthesis of unsaturated fatty acids HSD17B13 8.926762853 4.059823873 13.79370183 3.397610897 1.764520641 0.244811738 1 0.086830978 0.307726052 345275 hydroxysteroid 17-beta dehydrogenase 13 "GO:0003674,GO:0005515,GO:0005783,GO:0005811,GO:0005829,GO:0016229,GO:0016616,GO:0034389,GO:0046889,GO:0055114" "molecular_function|protein binding|endoplasmic reticulum|lipid droplet|cytosol|steroid dehydrogenase activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|lipid droplet organization|positive regulation of lipid biosynthetic process|oxidation-reduction process" HSD17B14 273.5348389 311.5914823 235.4781956 0.755727319 -0.404062319 0.407897673 1 14.97249464 11.80253285 51171 hydroxysteroid 17-beta dehydrogenase 14 "GO:0004303,GO:0005515,GO:0005829,GO:0006703,GO:0006706,GO:0042802,GO:0047045,GO:0055114" estradiol 17-beta-dehydrogenase activity|protein binding|cytosol|estrogen biosynthetic process|steroid catabolic process|identical protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity|oxidation-reduction process HSD17B3 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.012802974 0.038891405 3293 hydroxysteroid 17-beta dehydrogenase 3 "GO:0004303,GO:0005783,GO:0005789,GO:0006694,GO:0006702,GO:0030539,GO:0043231,GO:0047045,GO:0055114,GO:0061370" estradiol 17-beta-dehydrogenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|steroid biosynthetic process|androgen biosynthetic process|male genitalia development|intracellular membrane-bounded organelle|testosterone 17-beta-dehydrogenase (NADP+) activity|oxidation-reduction process|testosterone biosynthetic process hsa00140 Steroid hormone biosynthesis HSD17B4 2029.749864 2196.364716 1863.135012 0.848281252 -0.237385417 0.461121737 1 39.87029553 35.2781054 3295 hydroxysteroid 17-beta dehydrogenase 4 "GO:0000038,GO:0001649,GO:0003857,GO:0004300,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0006699,GO:0008209,GO:0008210,GO:0016020,GO:0016508,GO:0016853,GO:0033540,GO:0033989,GO:0036109,GO:0036111,GO:0036112,GO:0042803,GO:0044594,GO:0060009" "very long-chain fatty acid metabolic process|osteoblast differentiation|3-hydroxyacyl-CoA dehydrogenase activity|enoyl-CoA hydratase activity|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|bile acid biosynthetic process|androgen metabolic process|estrogen metabolic process|membrane|long-chain-enoyl-CoA hydratase activity|isomerase activity|fatty acid beta-oxidation using acyl-CoA oxidase|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|alpha-linolenic acid metabolic process|very long-chain fatty-acyl-CoA metabolic process|medium-chain fatty-acyl-CoA metabolic process|protein homodimerization activity|17-beta-hydroxysteroid dehydrogenase (NAD+) activity|Sertoli cell development" "hsa00120,hsa01040,hsa04146" Primary bile acid biosynthesis|Biosynthesis of unsaturated fatty acids|Peroxisome HSD17B6 35.43710584 31.46363502 39.41057666 1.252575446 0.324897503 0.750854624 1 0.845818533 1.105088401 8630 hydroxysteroid 17-beta dehydrogenase 6 "GO:0003824,GO:0004303,GO:0004745,GO:0005783,GO:0006702,GO:0006710,GO:0009055,GO:0016491,GO:0022900,GO:0031901,GO:0047023,GO:0047024,GO:0047035,GO:0047044,GO:0047045,GO:0062175" "catalytic activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|endoplasmic reticulum|androgen biosynthetic process|androgen catabolic process|electron transfer activity|oxidoreductase activity|electron transport chain|early endosome membrane|androsterone dehydrogenase activity|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NADP+) activity|brexanolone catabolic process" "hsa00140,hsa00830" Steroid hormone biosynthesis|Retinol metabolism HSD17B7 192.9767298 192.841634 193.1118256 1.001401106 0.002019955 1 1 5.56827164 5.816268008 51478 hydroxysteroid 17-beta dehydrogenase 7 "GO:0000253,GO:0004303,GO:0005783,GO:0005789,GO:0006695,GO:0006703,GO:0008209,GO:0016021,GO:0047024,GO:0055114" "3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|estrogen biosynthetic process|androgen metabolic process|integral component of membrane|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|oxidation-reduction process" "hsa00100,hsa00140,hsa04913" Steroid biosynthesis|Steroid hormone biosynthesis|Ovarian steroidogenesis HSD17B8 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.368298439 0.213099954 7923 hydroxysteroid 17-beta dehydrogenase 8 "GO:0003857,GO:0004303,GO:0005515,GO:0005740,GO:0005759,GO:0005886,GO:0006633,GO:0006703,GO:0008209,GO:0016616,GO:0046949,GO:0047025,GO:0047035,GO:0048038,GO:0051290,GO:0055114,GO:0070404" "3-hydroxyacyl-CoA dehydrogenase activity|estradiol 17-beta-dehydrogenase activity|protein binding|mitochondrial envelope|mitochondrial matrix|plasma membrane|fatty acid biosynthetic process|estrogen biosynthetic process|androgen metabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|fatty-acyl-CoA biosynthetic process|3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity|testosterone dehydrogenase (NAD+) activity|quinone binding|protein heterotetramerization|oxidation-reduction process|NADH binding" "hsa00061,hsa00140" Fatty acid biosynthesis|Steroid hormone biosynthesis HSD3B7 244.7422058 262.8735958 226.6108158 0.862052406 -0.214152518 0.675968342 1 5.577553525 5.015258757 80270 "hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7" "GO:0003854,GO:0005515,GO:0005789,GO:0005811,GO:0006699,GO:0016021,GO:0016616,GO:0035754,GO:0047016,GO:0055114" "3-beta-hydroxy-delta5-steroid dehydrogenase activity|protein binding|endoplasmic reticulum membrane|lipid droplet|bile acid biosynthetic process|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|B cell chemotaxis|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity|oxidation-reduction process" hsa00120 Primary bile acid biosynthesis HSDL1 654.6928669 739.9029009 569.4828328 0.769672388 -0.377683603 0.324697629 1 10.01964484 8.044038937 83693 hydroxysteroid dehydrogenase like 1 "GO:0005515,GO:0005739,GO:0016229,GO:0043231,GO:0045111,GO:0055114" protein binding|mitochondrion|steroid dehydrogenase activity|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|oxidation-reduction process HSDL2 1315.455427 1187.498483 1443.41237 1.215506707 0.281557854 0.4042972 1 18.22503301 23.10689616 84263 hydroxysteroid dehydrogenase like 2 "GO:0003674,GO:0005739,GO:0005777,GO:0008150,GO:0016020,GO:0016491,GO:0055114" molecular_function|mitochondrion|peroxisome|biological_process|membrane|oxidoreductase activity|oxidation-reduction process HSF1 2588.679579 2182.155332 2995.203826 1.372589651 0.456900383 0.152180172 1 48.9019776 70.01370693 3297 heat shock transcription factor 1 "GO:0000122,GO:0000165,GO:0000776,GO:0000777,GO:0000785,GO:0000791,GO:0000792,GO:0000978,GO:0000981,GO:0001162,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006281,GO:0006357,GO:0006397,GO:0006952,GO:0007584,GO:0008284,GO:0009299,GO:0010667,GO:0014823,GO:0016032,GO:0016605,GO:0019901,GO:0031072,GO:0031333,GO:0031490,GO:0033574,GO:0034605,GO:0034620,GO:0034622,GO:0035865,GO:0042531,GO:0042802,GO:0043280,GO:0043565,GO:0043621,GO:0045931,GO:0045944,GO:0046982,GO:0048471,GO:0051028,GO:0051879,GO:0061408,GO:0061770,GO:0070301,GO:0071222,GO:0071276,GO:0071280,GO:0071392,GO:0071480,GO:0072738,GO:0090084,GO:0090261,GO:0097165,GO:0097431,GO:0097677,GO:0098847,GO:0101031,GO:0120162,GO:1900034,GO:1900365,GO:1901215,GO:1902512,GO:1903936,GO:1904385,GO:1904528,GO:1904843,GO:1904845,GO:1990837,GO:1990841,GO:1990904,GO:1990910,GO:1990911,GO:2001033" "negative regulation of transcription by RNA polymerase II|MAPK cascade|kinetochore|condensed chromosome kinetochore|chromatin|euchromatin|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA repair|regulation of transcription by RNA polymerase II|mRNA processing|defense response|response to nutrient|positive regulation of cell population proliferation|mRNA transcription|negative regulation of cardiac muscle cell apoptotic process|response to activity|viral process|PML body|protein kinase binding|heat shock protein binding|negative regulation of protein-containing complex assembly|chromatin DNA binding|response to testosterone|cellular response to heat|cellular response to unfolded protein|cellular protein-containing complex assembly|cellular response to potassium ion|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|sequence-specific DNA binding|protein self-association|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|perinuclear region of cytoplasm|mRNA transport|Hsp90 protein binding|positive regulation of transcription from RNA polymerase II promoter in response to heat stress|translation elongation factor binding|cellular response to hydrogen peroxide|cellular response to lipopolysaccharide|cellular response to cadmium ion|cellular response to copper ion|cellular response to estradiol stimulus|cellular response to gamma radiation|cellular response to diamide|negative regulation of inclusion body assembly|positive regulation of inclusion body assembly|nuclear stress granule|mitotic spindle pole|STAT family protein binding|sequence-specific single stranded DNA binding|chaperone complex|positive regulation of cold-induced thermogenesis|regulation of cellular response to heat|positive regulation of mRNA polyadenylation|negative regulation of neuron death|positive regulation of apoptotic DNA fragmentation|cellular response to sodium arsenite|cellular response to angiotensin|positive regulation of microtubule binding|cellular response to nitroglycerin|cellular response to L-glutamine|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding|ribonucleoprotein complex|response to hypobaric hypoxia|response to psychosocial stress|negative regulation of double-strand break repair via nonhomologous end joining" hsa05134 Legionellosis HSF HSF2 285.7373211 236.4847406 334.9899016 1.416539184 0.50237051 0.296099769 1 4.151513984 6.134102482 3298 heat shock transcription factor 2 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001162,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007283,GO:0042802,GO:0045944,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|spermatogenesis|identical protein binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" HSF HSF2BP 43.54190781 46.68797455 40.39584108 0.865230104 -0.208844233 0.835537861 1 0.210465617 0.189945368 11077 heat shock transcription factor 2 binding protein "GO:0005515,GO:0005694,GO:0005829,GO:0006366,GO:0007141,GO:0007283,GO:1990918" protein binding|chromosome|cytosol|transcription by RNA polymerase II|male meiosis I|spermatogenesis|double-strand break repair involved in meiotic recombination HSF4 116.1909316 129.914364 102.4674993 0.788731101 -0.342394563 0.60131699 1 2.939992951 2.418751128 3299 heat shock transcription factor 4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006357,GO:0007601,GO:0008284,GO:0016607,GO:0033169,GO:0042802,GO:0043010,GO:0045597,GO:0045944,GO:0048468,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|visual perception|positive regulation of cell population proliferation|nuclear speck|histone H3-K9 demethylation|identical protein binding|camera-type eye development|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|cell development|sequence-specific double-stranded DNA binding" HSFX1 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.079546098 100506164 "heat shock transcription factor family, X-linked 1" "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006357" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II" HSH2D 8.926762853 4.059823873 13.79370183 3.397610897 1.764520641 0.244811738 1 0.077183092 0.273534269 84941 hematopoietic SH2 domain containing "GO:0005515,GO:0005634,GO:0005737,GO:0007165" protein binding|nucleus|cytoplasm|signal transduction HSP90AA1 20476.91399 19848.47892 21105.34907 1.063323248 0.08858024 0.808282004 1 255.4002632 283.2713024 3320 heat shock protein 90 alpha family class A member 1 "GO:0000086,GO:0001934,GO:0002218,GO:0002230,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006457,GO:0006839,GO:0006898,GO:0006986,GO:0007004,GO:0009408,GO:0009409,GO:0010389,GO:0016020,GO:0016032,GO:0016887,GO:0019221,GO:0021955,GO:0023026,GO:0030010,GO:0030235,GO:0030911,GO:0031396,GO:0031625,GO:0032273,GO:0032728,GO:0032991,GO:0033138,GO:0034605,GO:0034774,GO:0038096,GO:0038128,GO:0042026,GO:0042470,GO:0042802,GO:0042803,GO:0042826,GO:0042981,GO:0043025,GO:0043202,GO:0043209,GO:0043254,GO:0043312,GO:0043335,GO:0044183,GO:0044294,GO:0044295,GO:0045040,GO:0045429,GO:0046677,GO:0048010,GO:0048156,GO:0048471,GO:0048675,GO:0050821,GO:0050999,GO:0051020,GO:0051082,GO:0051131,GO:0051897,GO:0051973,GO:0061684,GO:0070062,GO:0070182,GO:0071682,GO:0097110,GO:0097711,GO:0097718,GO:0098586,GO:1900034,GO:1902949,GO:1903364,GO:1903827,GO:1904813,GO:1905323,GO:1990782" G2/M transition of mitotic cell cycle|positive regulation of protein phosphorylation|activation of innate immune response|positive regulation of defense response to virus by host|RNA binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|protein folding|mitochondrial transport|receptor-mediated endocytosis|response to unfolded protein|telomere maintenance via telomerase|response to heat|response to cold|regulation of G2/M transition of mitotic cell cycle|membrane|viral process|ATPase activity|cytokine-mediated signaling pathway|central nervous system neuron axonogenesis|MHC class II protein complex binding|establishment of cell polarity|nitric-oxide synthase regulator activity|TPR domain binding|regulation of protein ubiquitination|ubiquitin protein ligase binding|positive regulation of protein polymerization|positive regulation of interferon-beta production|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|cellular response to heat|secretory granule lumen|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|protein refolding|melanosome|identical protein binding|protein homodimerization activity|histone deacetylase binding|regulation of apoptotic process|neuronal cell body|lysosomal lumen|myelin sheath|regulation of protein-containing complex assembly|neutrophil degranulation|protein unfolding|protein folding chaperone|dendritic growth cone|axonal growth cone|protein insertion into mitochondrial outer membrane|positive regulation of nitric oxide biosynthetic process|response to antibiotic|vascular endothelial growth factor receptor signaling pathway|tau protein binding|perinuclear region of cytoplasm|axon extension|protein stabilization|regulation of nitric-oxide synthase activity|GTPase binding|unfolded protein binding|chaperone-mediated protein complex assembly|positive regulation of protein kinase B signaling|positive regulation of telomerase activity|chaperone-mediated autophagy|extracellular exosome|DNA polymerase binding|endocytic vesicle lumen|scaffold protein binding|ciliary basal body-plasma membrane docking|disordered domain specific binding|cellular response to virus|regulation of cellular response to heat|positive regulation of tau-protein kinase activity|positive regulation of cellular protein catabolic process|regulation of cellular protein localization|ficolin-1-rich granule lumen|telomerase holoenzyme complex assembly|protein tyrosine kinase binding "hsa04141,hsa04151,hsa04217,hsa04612,hsa04621,hsa04657,hsa04659,hsa04914,hsa04915,hsa05132,hsa05200,hsa05215,hsa05418" Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Necroptosis|Antigen processing and presentation|NOD-like receptor signaling pathway|IL-17 signaling pathway|Th17 cell differentiation|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Salmonella infection|Pathways in cancer|Prostate cancer|Fluid shear stress and atherosclerosis HSP90AB1 28549.17203 29749.37439 27348.96967 0.91931243 -0.121372847 0.752926763 1 527.5563247 505.88045 3326 heat shock protein 90 alpha family class B member 1 "GO:0001890,GO:0002134,GO:0002135,GO:0003723,GO:0003725,GO:0005515,GO:0005524,GO:0005525,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005765,GO:0005829,GO:0005886,GO:0006457,GO:0006805,GO:0006986,GO:0007004,GO:0008144,GO:0008180,GO:0009651,GO:0016020,GO:0016234,GO:0016323,GO:0016324,GO:0017098,GO:0019062,GO:0019887,GO:0019900,GO:0019901,GO:0021955,GO:0023026,GO:0030010,GO:0030235,GO:0030511,GO:0030911,GO:0031072,GO:0031396,GO:0031526,GO:0031625,GO:0032092,GO:0032435,GO:0032516,GO:0032564,GO:0032991,GO:0033138,GO:0034605,GO:0034751,GO:0034774,GO:0035690,GO:0038096,GO:0042220,GO:0042277,GO:0042307,GO:0042470,GO:0042802,GO:0042803,GO:0042826,GO:0043008,GO:0043025,GO:0043312,GO:0043524,GO:0044183,GO:0044294,GO:0044295,GO:0044325,GO:0045296,GO:0045429,GO:0045597,GO:0045793,GO:0046983,GO:0048156,GO:0048471,GO:0048675,GO:0050821,GO:0051082,GO:0051131,GO:0051248,GO:0051897,GO:0051973,GO:0060334,GO:0060338,GO:0070062,GO:0070182,GO:0071157,GO:0071353,GO:0071407,GO:0071902,GO:0097435,GO:0097718,GO:1900034,GO:1901389,GO:1901799,GO:1902949,GO:1903660,GO:1903827,GO:1904031,GO:1904813,GO:1905323,GO:1990226,GO:1990565,GO:1990913,GO:1990917,GO:2000010" placenta development|UTP binding|CTP binding|RNA binding|double-stranded RNA binding|protein binding|ATP binding|GTP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|lysosomal membrane|cytosol|plasma membrane|protein folding|xenobiotic metabolic process|response to unfolded protein|telomere maintenance via telomerase|drug binding|COP9 signalosome|response to salt stress|membrane|inclusion body|basolateral plasma membrane|apical plasma membrane|sulfonylurea receptor binding|virion attachment to host cell|protein kinase regulator activity|kinase binding|protein kinase binding|central nervous system neuron axonogenesis|MHC class II protein complex binding|establishment of cell polarity|nitric-oxide synthase regulator activity|positive regulation of transforming growth factor beta receptor signaling pathway|TPR domain binding|heat shock protein binding|regulation of protein ubiquitination|brush border membrane|ubiquitin protein ligase binding|positive regulation of protein binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of phosphoprotein phosphatase activity|dATP binding|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|cellular response to heat|aryl hydrocarbon receptor complex|secretory granule lumen|cellular response to drug|Fc-gamma receptor signaling pathway involved in phagocytosis|response to cocaine|peptide binding|positive regulation of protein import into nucleus|melanosome|identical protein binding|protein homodimerization activity|histone deacetylase binding|ATP-dependent protein binding|neuronal cell body|neutrophil degranulation|negative regulation of neuron apoptotic process|protein folding chaperone|dendritic growth cone|axonal growth cone|ion channel binding|cadherin binding|positive regulation of nitric oxide biosynthetic process|positive regulation of cell differentiation|positive regulation of cell size|protein dimerization activity|tau protein binding|perinuclear region of cytoplasm|axon extension|protein stabilization|unfolded protein binding|chaperone-mediated protein complex assembly|negative regulation of protein metabolic process|positive regulation of protein kinase B signaling|positive regulation of telomerase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|extracellular exosome|DNA polymerase binding|negative regulation of cell cycle arrest|cellular response to interleukin-4|cellular response to organic cyclic compound|positive regulation of protein serine/threonine kinase activity|supramolecular fiber organization|disordered domain specific binding|regulation of cellular response to heat|negative regulation of transforming growth factor beta activation|negative regulation of proteasomal protein catabolic process|positive regulation of tau-protein kinase activity|negative regulation of complement-dependent cytotoxicity|regulation of cellular protein localization|positive regulation of cyclin-dependent protein kinase activity|ficolin-1-rich granule lumen|telomerase holoenzyme complex assembly|histone methyltransferase binding|HSP90-CDC37 chaperone complex|sperm head plasma membrane|ooplasm|positive regulation of protein localization to cell surface "hsa04141,hsa04151,hsa04217,hsa04612,hsa04621,hsa04657,hsa04659,hsa04914,hsa04915,hsa05132,hsa05200,hsa05215,hsa05418" Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Necroptosis|Antigen processing and presentation|NOD-like receptor signaling pathway|IL-17 signaling pathway|Th17 cell differentiation|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Salmonella infection|Pathways in cancer|Prostate cancer|Fluid shear stress and atherosclerosis HSP90B1 24668.17366 25671.28131 23665.06602 0.921849819 -0.117396359 0.754744041 1 467.347173 449.3820534 7184 heat shock protein 90 beta family member 1 "GO:0001666,GO:0002224,GO:0003723,GO:0005509,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005783,GO:0005788,GO:0005789,GO:0005829,GO:0005925,GO:0006457,GO:0006898,GO:0015031,GO:0016020,GO:0019221,GO:0019903,GO:0030433,GO:0030496,GO:0030970,GO:0031247,GO:0032991,GO:0033018,GO:0034975,GO:0034976,GO:0036500,GO:0042470,GO:0043066,GO:0043666,GO:0043687,GO:0044267,GO:0048471,GO:0050750,GO:0051082,GO:0051208,GO:0062023,GO:0070062,GO:0071318,GO:0071682" "response to hypoxia|toll-like receptor signaling pathway|RNA binding|calcium ion binding|protein binding|ATP binding|extracellular region|nucleus|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|cytosol|focal adhesion|protein folding|receptor-mediated endocytosis|protein transport|membrane|cytokine-mediated signaling pathway|protein phosphatase binding|ubiquitin-dependent ERAD pathway|midbody|retrograde protein transport, ER to cytosol|actin rod assembly|protein-containing complex|sarcoplasmic reticulum lumen|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|ATF6-mediated unfolded protein response|melanosome|negative regulation of apoptotic process|regulation of phosphoprotein phosphatase activity|post-translational protein modification|cellular protein metabolic process|perinuclear region of cytoplasm|low-density lipoprotein particle receptor binding|unfolded protein binding|sequestering of calcium ion|collagen-containing extracellular matrix|extracellular exosome|cellular response to ATP|endocytic vesicle lumen" "hsa04141,hsa04151,hsa04657,hsa04915,hsa04918,hsa05132,hsa05200,hsa05215,hsa05418" Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|IL-17 signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Salmonella infection|Pathways in cancer|Prostate cancer|Fluid shear stress and atherosclerosis HSPA12A 163.3594142 188.7818101 137.9370183 0.73066901 -0.452710075 0.433950349 1 1.022034495 0.77893671 259217 heat shock protein family A (Hsp70) member 12A "GO:0003674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0008150,GO:0070062" molecular_function|protein binding|ATP binding|nucleus|cytoplasm|biological_process|extracellular exosome HSPA13 1286.295362 1618.85477 953.7359552 0.589142382 -0.763311753 0.024626994 0.693409464 20.78308824 12.77162851 6782 heat shock protein family A (Hsp70) member 13 "GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005783,GO:0016887,GO:0031072,GO:0034620,GO:0042026,GO:0043231,GO:0044183,GO:0051082,GO:0051085,GO:0051787,GO:0070062" protein binding|ATP binding|cytoplasm|mitochondrion|endoplasmic reticulum|ATPase activity|heat shock protein binding|cellular response to unfolded protein|protein refolding|intracellular membrane-bounded organelle|protein folding chaperone|unfolded protein binding|chaperone cofactor-dependent protein refolding|misfolded protein binding|extracellular exosome HSPA14 379.8016191 402.9375194 356.6657188 0.885163832 -0.175983591 0.692849069 1 11.58193183 10.69351774 51182 heat shock protein family A (Hsp70) member 14 "GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0016020,GO:0016192,GO:0016887,GO:0031072,GO:0034620,GO:0042026,GO:0044183,GO:0051082,GO:0051083,GO:0051085,GO:0051787" protein binding|ATP binding|nucleus|cytoplasm|cytosol|ribosome|plasma membrane|membrane|vesicle-mediated transport|ATPase activity|heat shock protein binding|cellular response to unfolded protein|protein refolding|protein folding chaperone|unfolded protein binding|'de novo' cotranslational protein folding|chaperone cofactor-dependent protein refolding|misfolded protein binding HSPA1A 456.4538053 456.7301858 456.1774249 0.998789743 -0.001747089 1 1 9.638238609 10.04124762 3303 heat shock protein family A (Hsp70) member 1A "GO:0001618,GO:0001664,GO:0003714,GO:0003723,GO:0005102,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005925,GO:0006402,GO:0006986,GO:0007041,GO:0008180,GO:0008285,GO:0010628,GO:0010941,GO:0016192,GO:0016234,GO:0016235,GO:0016607,GO:0016887,GO:0019899,GO:0030308,GO:0030512,GO:0031072,GO:0031249,GO:0031396,GO:0031397,GO:0031625,GO:0031982,GO:0032436,GO:0032757,GO:0032991,GO:0033120,GO:0034599,GO:0034605,GO:0034620,GO:0042026,GO:0042826,GO:0043066,GO:0043312,GO:0043488,GO:0044183,GO:0045296,GO:0045648,GO:0046034,GO:0046718,GO:0047485,GO:0048471,GO:0050821,GO:0051082,GO:0051085,GO:0051092,GO:0051131,GO:0051787,GO:0055131,GO:0060548,GO:0070062,GO:0070370,GO:0070434,GO:0072562,GO:0090063,GO:0090084,GO:0097201,GO:0097718,GO:1900034,GO:1901029,GO:1901673,GO:1902236,GO:1902380,GO:1903265,GO:1904813,GO:1990904,GO:2001240" virus receptor activity|G protein-coupled receptor binding|transcription corepressor activity|RNA binding|signaling receptor binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|centrosome|centriole|cytosol|plasma membrane|focal adhesion|mRNA catabolic process|response to unfolded protein|lysosomal transport|COP9 signalosome|negative regulation of cell population proliferation|positive regulation of gene expression|regulation of cell death|vesicle-mediated transport|inclusion body|aggresome|nuclear speck|ATPase activity|enzyme binding|negative regulation of cell growth|negative regulation of transforming growth factor beta receptor signaling pathway|heat shock protein binding|denatured protein binding|regulation of protein ubiquitination|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|vesicle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of interleukin-8 production|protein-containing complex|positive regulation of RNA splicing|cellular response to oxidative stress|cellular response to heat|cellular response to unfolded protein|protein refolding|histone deacetylase binding|negative regulation of apoptotic process|neutrophil degranulation|regulation of mRNA stability|protein folding chaperone|cadherin binding|positive regulation of erythrocyte differentiation|ATP metabolic process|viral entry into host cell|protein N-terminus binding|perinuclear region of cytoplasm|protein stabilization|unfolded protein binding|chaperone cofactor-dependent protein refolding|positive regulation of NF-kappaB transcription factor activity|chaperone-mediated protein complex assembly|misfolded protein binding|C3HC4-type RING finger domain binding|negative regulation of cell death|extracellular exosome|cellular heat acclimation|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|blood microparticle|positive regulation of microtubule nucleation|negative regulation of inclusion body assembly|negative regulation of transcription from RNA polymerase II promoter in response to stress|disordered domain specific binding|regulation of cellular response to heat|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|regulation of mitotic spindle assembly|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of endoribonuclease activity|positive regulation of tumor necrosis factor-mediated signaling pathway|ficolin-1-rich granule lumen|ribonucleoprotein complex|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA1B 899.9385913 868.8023089 931.0748736 1.071676334 0.099869251 0.783233236 1 17.48183234 19.54188804 3304 heat shock protein family A (Hsp70) member 1B "GO:0001618,GO:0001664,GO:0003723,GO:0005102,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005925,GO:0006402,GO:0008180,GO:0008285,GO:0010628,GO:0010941,GO:0016192,GO:0016234,GO:0016235,GO:0016607,GO:0016887,GO:0019899,GO:0030308,GO:0031072,GO:0031396,GO:0031397,GO:0031625,GO:0031982,GO:0032436,GO:0032757,GO:0032991,GO:0034599,GO:0034605,GO:0034620,GO:0042026,GO:0042826,GO:0043066,GO:0043312,GO:0044183,GO:0045648,GO:0046034,GO:0046718,GO:0047485,GO:0048471,GO:0050821,GO:0051082,GO:0051085,GO:0051092,GO:0051787,GO:0055131,GO:0060548,GO:0070062,GO:0070370,GO:0070434,GO:0072562,GO:0090063,GO:0090084,GO:1900034,GO:1901673,GO:1903265,GO:1904813,GO:1990904,GO:2001240" virus receptor activity|G protein-coupled receptor binding|RNA binding|signaling receptor binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|centrosome|centriole|cytosol|plasma membrane|focal adhesion|mRNA catabolic process|COP9 signalosome|negative regulation of cell population proliferation|positive regulation of gene expression|regulation of cell death|vesicle-mediated transport|inclusion body|aggresome|nuclear speck|ATPase activity|enzyme binding|negative regulation of cell growth|heat shock protein binding|regulation of protein ubiquitination|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|vesicle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of interleukin-8 production|protein-containing complex|cellular response to oxidative stress|cellular response to heat|cellular response to unfolded protein|protein refolding|histone deacetylase binding|negative regulation of apoptotic process|neutrophil degranulation|protein folding chaperone|positive regulation of erythrocyte differentiation|ATP metabolic process|viral entry into host cell|protein N-terminus binding|perinuclear region of cytoplasm|protein stabilization|unfolded protein binding|chaperone cofactor-dependent protein refolding|positive regulation of NF-kappaB transcription factor activity|misfolded protein binding|C3HC4-type RING finger domain binding|negative regulation of cell death|extracellular exosome|cellular heat acclimation|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|blood microparticle|positive regulation of microtubule nucleation|negative regulation of inclusion body assembly|regulation of cellular response to heat|regulation of mitotic spindle assembly|positive regulation of tumor necrosis factor-mediated signaling pathway|ficolin-1-rich granule lumen|ribonucleoprotein complex|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA1L 34.07797542 39.58328277 28.57266808 0.721836747 -0.470255505 0.636416315 1 0.725834044 0.546502624 3305 heat shock protein family A (Hsp70) member 1 like "GO:0002199,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005829,GO:0005886,GO:0006986,GO:0007339,GO:0008180,GO:0016192,GO:0016887,GO:0031072,GO:0031625,GO:0034620,GO:0042026,GO:0044183,GO:0044297,GO:0051082,GO:0051085,GO:0051787,GO:0072562,GO:1900034,GO:1903955" zona pellucida receptor complex|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|cytosol|plasma membrane|response to unfolded protein|binding of sperm to zona pellucida|COP9 signalosome|vesicle-mediated transport|ATPase activity|heat shock protein binding|ubiquitin protein ligase binding|cellular response to unfolded protein|protein refolding|protein folding chaperone|cell body|unfolded protein binding|chaperone cofactor-dependent protein refolding|misfolded protein binding|blood microparticle|regulation of cellular response to heat|positive regulation of protein targeting to mitochondrion "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA2 69.64869325 80.1815215 59.11586499 0.737275421 -0.439724434 0.57196384 1 1.581351714 1.216113638 3306 heat shock protein family A (Hsp70) member 2 "GO:0000795,GO:0001673,GO:0001934,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006986,GO:0007140,GO:0007141,GO:0007283,GO:0007286,GO:0009408,GO:0009409,GO:0009986,GO:0010971,GO:0016020,GO:0016192,GO:0016887,GO:0019899,GO:0031072,GO:0032781,GO:0034620,GO:0036128,GO:0042026,GO:0044183,GO:0048156,GO:0051082,GO:0051085,GO:0051087,GO:0051787,GO:0051861,GO:0070062,GO:0070194,GO:0072562,GO:0072687,GO:0090084,GO:0097718,GO:1901896" synaptonemal complex|male germ cell nucleus|positive regulation of protein phosphorylation|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|response to unfolded protein|male meiotic nuclear division|male meiosis I|spermatogenesis|spermatid development|response to heat|response to cold|cell surface|positive regulation of G2/M transition of mitotic cell cycle|membrane|vesicle-mediated transport|ATPase activity|enzyme binding|heat shock protein binding|positive regulation of ATPase activity|cellular response to unfolded protein|CatSper complex|protein refolding|protein folding chaperone|tau protein binding|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|misfolded protein binding|glycolipid binding|extracellular exosome|synaptonemal complex disassembly|blood microparticle|meiotic spindle|negative regulation of inclusion body assembly|disordered domain specific binding|positive regulation of ATPase-coupled calcium transmembrane transporter activity "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA4 3991.404397 4486.10538 3496.703414 0.779451912 -0.359468076 0.259595304 1 47.59225209 38.69381158 3308 heat shock protein family A (Hsp70) member 4 "GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005829,GO:0006986,GO:0045040,GO:0051131,GO:0070062" protein binding|ATP binding|nucleus|mitochondrion|cytosol|response to unfolded protein|protein insertion into mitochondrial outer membrane|chaperone-mediated protein complex assembly|extracellular exosome "hsa04530,hsa04612" Tight junction|Antigen processing and presentation HSPA4L 578.9274678 612.0184489 545.8364868 0.891862799 -0.165106307 0.677812196 1 2.542578572 2.365311598 22824 heat shock protein family A (Hsp70) member 4 like "GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006457,GO:0006986" ATP binding|nucleus|cytoplasm|cytosol|protein folding|response to unfolded protein hsa04141 Protein processing in endoplasmic reticulum HSPA5 20237.67017 19894.15194 20581.1884 1.034534594 0.048981889 0.893147673 1 256.9672566 277.2928909 3309 heat shock protein family A (Hsp70) member 5 "GO:0001554,GO:0005509,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005783,GO:0005788,GO:0005789,GO:0005790,GO:0005793,GO:0005829,GO:0005886,GO:0005925,GO:0006983,GO:0008180,GO:0009986,GO:0010976,GO:0016020,GO:0016887,GO:0019899,GO:0019904,GO:0021589,GO:0021680,GO:0021762,GO:0030176,GO:0030182,GO:0030335,GO:0030433,GO:0030496,GO:0030512,GO:0030968,GO:0031072,GO:0031204,GO:0031333,GO:0031398,GO:0031625,GO:0032991,GO:0034620,GO:0034663,GO:0034975,GO:0035437,GO:0035690,GO:0036498,GO:0036499,GO:0036500,GO:0042026,GO:0042149,GO:0042220,GO:0042470,GO:0043022,GO:0043066,GO:0043231,GO:0044183,GO:0045296,GO:0051082,GO:0051085,GO:0051087,GO:0051402,GO:0051787,GO:0060904,GO:0070062,GO:0071236,GO:0071277,GO:0071287,GO:0071320,GO:0071353,GO:0071480,GO:0097501,GO:1901998,GO:1903891,GO:1903894,GO:1903895,GO:1903897,GO:1904313,GO:1990090,GO:1990440" "luteolysis|calcium ion binding|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|smooth endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|focal adhesion|ER overload response|COP9 signalosome|cell surface|positive regulation of neuron projection development|membrane|ATPase activity|enzyme binding|protein domain specific binding|cerebellum structural organization|cerebellar Purkinje cell layer development|substantia nigra development|integral component of endoplasmic reticulum membrane|neuron differentiation|positive regulation of cell migration|ubiquitin-dependent ERAD pathway|midbody|negative regulation of transforming growth factor beta receptor signaling pathway|endoplasmic reticulum unfolded protein response|heat shock protein binding|posttranslational protein targeting to membrane, translocation|negative regulation of protein-containing complex assembly|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein-containing complex|cellular response to unfolded protein|endoplasmic reticulum chaperone complex|protein folding in endoplasmic reticulum|maintenance of protein localization in endoplasmic reticulum|cellular response to drug|IRE1-mediated unfolded protein response|PERK-mediated unfolded protein response|ATF6-mediated unfolded protein response|protein refolding|cellular response to glucose starvation|response to cocaine|melanosome|ribosome binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|protein folding chaperone|cadherin binding|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|neuron apoptotic process|misfolded protein binding|regulation of protein folding in endoplasmic reticulum|extracellular exosome|cellular response to antibiotic|cellular response to calcium ion|cellular response to manganese ion|cellular response to cAMP|cellular response to interleukin-4|cellular response to gamma radiation|stress response to metal ion|toxin transport|regulation of ATF6-mediated unfolded protein response|regulation of IRE1-mediated unfolded protein response|negative regulation of IRE1-mediated unfolded protein response|regulation of PERK-mediated unfolded protein response|response to methamphetamine hydrochloride|cellular response to nerve growth factor stimulus|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" "hsa03060,hsa04141,hsa04612,hsa04918,hsa05012,hsa05014,hsa05020,hsa05022" Protein export|Protein processing in endoplasmic reticulum|Antigen processing and presentation|Thyroid hormone synthesis|Parkinson disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases HSPA6 10.04563925 13.19442759 6.896850916 0.522709369 -0.935919077 0.529573094 1 0.283758476 0.154712376 3310 heat shock protein family A (Hsp70) member 6 "GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005814,GO:0005829,GO:0005886,GO:0006986,GO:0008180,GO:0016192,GO:0016887,GO:0019899,GO:0031072,GO:0031625,GO:0034605,GO:0034620,GO:0034774,GO:0042026,GO:0043312,GO:0044183,GO:0051082,GO:0051085,GO:0051787,GO:0070062,GO:0070370,GO:0072562,GO:1904813" protein binding|ATP binding|extracellular region|nucleus|cytoplasm|centriole|cytosol|plasma membrane|response to unfolded protein|COP9 signalosome|vesicle-mediated transport|ATPase activity|enzyme binding|heat shock protein binding|ubiquitin protein ligase binding|cellular response to heat|cellular response to unfolded protein|secretory granule lumen|protein refolding|neutrophil degranulation|protein folding chaperone|unfolded protein binding|chaperone cofactor-dependent protein refolding|misfolded protein binding|extracellular exosome|cellular heat acclimation|blood microparticle|ficolin-1-rich granule lumen "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA8 40385.03624 43684.71983 37085.35264 0.84893191 -0.236279251 0.565256396 1 968.6851792 857.7711655 3312 heat shock protein family A (Hsp70) member 8 "GO:0000398,GO:0000974,GO:0001664,GO:0001786,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005737,GO:0005764,GO:0005765,GO:0005770,GO:0005776,GO:0005829,GO:0005886,GO:0005925,GO:0006457,GO:0006986,GO:0007269,GO:0009267,GO:0016020,GO:0016032,GO:0016192,GO:0016887,GO:0019221,GO:0019899,GO:0023026,GO:0030425,GO:0030674,GO:0031072,GO:0031625,GO:0031647,GO:0034620,GO:0034774,GO:0042026,GO:0042470,GO:0043195,GO:0043202,GO:0043254,GO:0043312,GO:0043488,GO:0044183,GO:0044829,GO:0045296,GO:0045892,GO:0046034,GO:0048026,GO:0048471,GO:0051082,GO:0051085,GO:0051087,GO:0051726,GO:0051787,GO:0055131,GO:0061024,GO:0061202,GO:0061635,GO:0061684,GO:0061738,GO:0061740,GO:0061741,GO:0070062,GO:0072318,GO:0072562,GO:0098575,GO:0098684,GO:0098690,GO:0098978,GO:0099175,GO:0099523,GO:0099524,GO:0099634,GO:0101031,GO:1900034,GO:1902904,GO:1904589,GO:1904764,GO:1904813,GO:1990832,GO:1990833,GO:1990904" "mRNA splicing, via spliceosome|Prp19 complex|G protein-coupled receptor binding|phosphatidylserine binding|RNA binding|protein binding|ATP binding|extracellular region|extracellular space|nucleus|nucleoplasm|spliceosomal complex|nucleolus|cytoplasm|lysosome|lysosomal membrane|late endosome|autophagosome|cytosol|plasma membrane|focal adhesion|protein folding|response to unfolded protein|neurotransmitter secretion|cellular response to starvation|membrane|viral process|vesicle-mediated transport|ATPase activity|cytokine-mediated signaling pathway|enzyme binding|MHC class II protein complex binding|dendrite|protein-macromolecule adaptor activity|heat shock protein binding|ubiquitin protein ligase binding|regulation of protein stability|cellular response to unfolded protein|secretory granule lumen|protein refolding|melanosome|terminal bouton|lysosomal lumen|regulation of protein-containing complex assembly|neutrophil degranulation|regulation of mRNA stability|protein folding chaperone|positive regulation by host of viral genome replication|cadherin binding|negative regulation of transcription, DNA-templated|ATP metabolic process|positive regulation of mRNA splicing, via spliceosome|perinuclear region of cytoplasm|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|regulation of cell cycle|misfolded protein binding|C3HC4-type RING finger domain binding|membrane organization|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|regulation of protein complex stability|chaperone-mediated autophagy|late endosomal microautophagy|protein targeting to lysosome involved in chaperone-mediated autophagy|chaperone-mediated protein transport involved in chaperone-mediated autophagy|extracellular exosome|clathrin coat disassembly|blood microparticle|lumenal side of lysosomal membrane|photoreceptor ribbon synapse|glycinergic synapse|glutamatergic synapse|regulation of postsynapse organization|presynaptic cytosol|postsynaptic cytosol|postsynaptic specialization membrane|chaperone complex|regulation of cellular response to heat|negative regulation of supramolecular fiber organization|regulation of protein import|chaperone-mediated autophagy translocation complex disassembly|ficolin-1-rich granule lumen|slow axonal transport|clathrin-uncoating ATPase activity|ribonucleoprotein complex" "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA9 7142.377502 8062.810213 6221.94479 0.771684391 -0.37391717 0.25459302 1 92.72318197 74.63524666 3313 heat shock protein family A (Hsp70) member 9 "GO:0001401,GO:0003723,GO:0005515,GO:0005524,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0005925,GO:0006611,GO:0007007,GO:0016226,GO:0016887,GO:0030218,GO:0031072,GO:0031625,GO:0034620,GO:0035722,GO:0042026,GO:0042645,GO:0043066,GO:0044183,GO:0045646,GO:0045647,GO:0051082,GO:0051085,GO:0051787,GO:0070062,GO:0140275,GO:1902037,GO:1903707" SAM complex|RNA binding|protein binding|ATP binding|nucleolus|cytoplasm|mitochondrion|mitochondrial matrix|focal adhesion|protein export from nucleus|inner mitochondrial membrane organization|iron-sulfur cluster assembly|ATPase activity|erythrocyte differentiation|heat shock protein binding|ubiquitin protein ligase binding|cellular response to unfolded protein|interleukin-12-mediated signaling pathway|protein refolding|mitochondrial nucleoid|negative regulation of apoptotic process|protein folding chaperone|regulation of erythrocyte differentiation|negative regulation of erythrocyte differentiation|unfolded protein binding|chaperone cofactor-dependent protein refolding|misfolded protein binding|extracellular exosome|MIB complex|negative regulation of hematopoietic stem cell differentiation|negative regulation of hemopoiesis "hsa03018,hsa05152" RNA degradation|Tuberculosis HSPB1 5235.445475 6011.584201 4459.306749 0.741785626 -0.430925783 0.18100774 1 391.8475317 303.1876164 3315 heat shock protein family B (small) member 1 "GO:0000502,GO:0001895,GO:0001932,GO:0003723,GO:0005080,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0005925,GO:0006446,GO:0006469,GO:0006986,GO:0008426,GO:0009615,GO:0010506,GO:0016032,GO:0019901,GO:0032731,GO:0032760,GO:0035556,GO:0035924,GO:0038033,GO:0042802,GO:0042803,GO:0043066,GO:0043122,GO:0043130,GO:0043488,GO:0043536,GO:0044183,GO:0045766,GO:0061077,GO:0061629,GO:0070062,GO:0070527,GO:0071901,GO:0099641,GO:1902176,GO:1904115,GO:2001028" proteasome complex|retina homeostasis|regulation of protein phosphorylation|RNA binding|protein kinase C binding|protein binding|extracellular space|nucleus|cytoplasm|spindle|cytosol|cytoskeleton|focal adhesion|regulation of translational initiation|negative regulation of protein kinase activity|response to unfolded protein|protein kinase C inhibitor activity|response to virus|regulation of autophagy|viral process|protein kinase binding|positive regulation of interleukin-1 beta production|positive regulation of tumor necrosis factor production|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|regulation of mRNA stability|positive regulation of blood vessel endothelial cell migration|protein folding chaperone|positive regulation of angiogenesis|chaperone-mediated protein folding|RNA polymerase II-specific DNA-binding transcription factor binding|extracellular exosome|platelet aggregation|negative regulation of protein serine/threonine kinase activity|anterograde axonal protein transport|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|axon cytoplasm|positive regulation of endothelial cell chemotaxis "hsa04010,hsa04370,hsa05146" MAPK signaling pathway|VEGF signaling pathway|Amoebiasis HSPB11 810.0231918 716.5589137 903.48747 1.260869766 0.334419269 0.361818476 1 27.95930748 36.77160371 51668 heat shock protein family B (small) member 11 "GO:0001822,GO:0005515,GO:0005813,GO:0005929,GO:0007283,GO:0030154,GO:0030992,GO:0035735,GO:0046872,GO:0060271,GO:0097542" kidney development|protein binding|centrosome|cilium|spermatogenesis|cell differentiation|intraciliary transport particle B|intraciliary transport involved in cilium assembly|metal ion binding|cilium assembly|ciliary tip HSPB6 4.985705186 4.059823873 5.911586499 1.456118956 0.542128219 0.871693704 1 0.14083271 0.213902728 126393 heat shock protein family B (small) member 6 "GO:0005212,GO:0005515,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0006937,GO:0010667,GO:0042803,GO:0045766,GO:0051082,GO:0051087,GO:0061077" structural constituent of eye lens|protein binding|extracellular region|nucleus|nucleolus|cytoplasm|Golgi apparatus|cytosol|regulation of muscle contraction|negative regulation of cardiac muscle cell apoptotic process|protein homodimerization activity|positive regulation of angiogenesis|unfolded protein binding|chaperone binding|chaperone-mediated protein folding HSPB8 7.582478211 13.19442759 1.970528833 0.149345534 -2.743273999 0.107580465 1 0.359081789 0.055937307 26353 heat shock protein family B (small) member 8 "GO:0004672,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0016604,GO:0034620,GO:0042802,GO:0042803,GO:0101031,GO:1900034,GO:1905337" protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|nuclear body|cellular response to unfolded protein|identical protein binding|protein homodimerization activity|chaperone complex|regulation of cellular response to heat|positive regulation of aggrephagy HSPBAP1 148.9300656 111.6451565 186.2149747 1.667918077 0.738048429 0.214702774 1 1.18715795 2.065376116 79663 HSPB1 associated protein 1 "GO:0005515,GO:0005737,GO:0016706,GO:0055114" protein binding|cytoplasm|2-oxoglutarate-dependent dioxygenase activity|oxidation-reduction process HSPBP1 568.7954755 559.2407386 578.3502125 1.03417039 0.048473903 0.906932348 1 14.13351823 15.24608413 23640 HSPA (Hsp70) binding protein 1 "GO:0000774,GO:0004857,GO:0005515,GO:0005783,GO:0006457,GO:0031398,GO:0031625,GO:0032436,GO:0043086" adenyl-nucleotide exchange factor activity|enzyme inhibitor activity|protein binding|endoplasmic reticulum|protein folding|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of catalytic activity hsa04141 Protein processing in endoplasmic reticulum HSPD1 6962.793884 7472.105839 6453.481928 0.863676461 -0.211437124 0.518499641 1 160.3541529 144.4598717 3329 heat shock protein family D (Hsp60) member 1 "GO:0001530,GO:0002039,GO:0002755,GO:0002842,GO:0003688,GO:0003697,GO:0003723,GO:0003725,GO:0005515,GO:0005524,GO:0005615,GO:0005737,GO:0005739,GO:0005743,GO:0005759,GO:0005769,GO:0005829,GO:0005886,GO:0005905,GO:0006357,GO:0006457,GO:0006458,GO:0006919,GO:0006986,GO:0008035,GO:0008637,GO:0009409,GO:0009986,GO:0016020,GO:0016032,GO:0016853,GO:0016887,GO:0019899,GO:0030135,GO:0030141,GO:0031625,GO:0032727,GO:0032729,GO:0032733,GO:0032735,GO:0032755,GO:0032991,GO:0034185,GO:0034186,GO:0034514,GO:0042026,GO:0042100,GO:0042110,GO:0042113,GO:0043032,GO:0043065,GO:0043066,GO:0044406,GO:0045041,GO:0046696,GO:0048291,GO:0050821,GO:0050870,GO:0051082,GO:0051087,GO:0051131,GO:0051604,GO:0051702,GO:0070062" lipopolysaccharide binding|p53 binding|MyD88-dependent toll-like receptor signaling pathway|positive regulation of T cell mediated immune response to tumor cell|DNA replication origin binding|single-stranded DNA binding|RNA binding|double-stranded RNA binding|protein binding|ATP binding|extracellular space|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|early endosome|cytosol|plasma membrane|clathrin-coated pit|regulation of transcription by RNA polymerase II|protein folding|'de novo' protein folding|activation of cysteine-type endopeptidase activity involved in apoptotic process|response to unfolded protein|high-density lipoprotein particle binding|apoptotic mitochondrial changes|response to cold|cell surface|membrane|viral process|isomerase activity|ATPase activity|enzyme binding|coated vesicle|secretory granule|ubiquitin protein ligase binding|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|protein-containing complex|apolipoprotein binding|apolipoprotein A-I binding|mitochondrial unfolded protein response|protein refolding|B cell proliferation|T cell activation|B cell activation|positive regulation of macrophage activation|positive regulation of apoptotic process|negative regulation of apoptotic process|adhesion of symbiont to host|protein import into mitochondrial intermembrane space|lipopolysaccharide receptor complex|isotype switching to IgG isotypes|protein stabilization|positive regulation of T cell activation|unfolded protein binding|chaperone binding|chaperone-mediated protein complex assembly|protein maturation|biological process involved in interaction with symbiont|extracellular exosome "hsa03018,hsa04940,hsa05134,hsa05152" RNA degradation|Type I diabetes mellitus|Legionellosis|Tuberculosis HSPE1 137.1635541 149.1985274 125.1285809 0.838671689 -0.253821939 0.684421077 1 13.56621018 11.86769711 3336 heat shock protein family E (Hsp10) member 1 "GO:0001649,GO:0003723,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006457,GO:0006919,GO:0006986,GO:0016020,GO:0046872,GO:0051082,GO:0051085,GO:0051087,GO:0070062" osteoblast differentiation|RNA binding|protein binding|ATP binding|mitochondrion|mitochondrial matrix|protein folding|activation of cysteine-type endopeptidase activity involved in apoptotic process|response to unfolded protein|membrane|metal ion binding|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|extracellular exosome HSPG2 200.980333 167.4677348 234.4929311 1.400227521 0.485661268 0.368093468 1 0.564277159 0.824151418 3339 heparan sulfate proteoglycan 2 "GO:0001523,GO:0001525,GO:0001540,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005796,GO:0005886,GO:0005925,GO:0006024,GO:0006027,GO:0006629,GO:0006898,GO:0006954,GO:0007420,GO:0008022,GO:0009887,GO:0009888,GO:0016525,GO:0030021,GO:0030154,GO:0030198,GO:0043202,GO:0044267,GO:0050750,GO:0062023,GO:0070062,GO:0072359,GO:0098797" retinoid metabolic process|angiogenesis|amyloid-beta binding|calcium ion binding|protein binding|extracellular region|basement membrane|extracellular space|Golgi lumen|plasma membrane|focal adhesion|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|lipid metabolic process|receptor-mediated endocytosis|inflammatory response|brain development|protein C-terminus binding|animal organ morphogenesis|tissue development|negative regulation of angiogenesis|extracellular matrix structural constituent conferring compression resistance|cell differentiation|extracellular matrix organization|lysosomal lumen|cellular protein metabolic process|low-density lipoprotein particle receptor binding|collagen-containing extracellular matrix|extracellular exosome|circulatory system development|plasma membrane protein complex "hsa04512,hsa05161,hsa05205" ECM-receptor interaction|Hepatitis B|Proteoglycans in cancer HSPH1 2866.053785 3194.066432 2538.041137 0.794611255 -0.331678866 0.297523115 1 28.50038704 23.62225752 10808 heat shock protein family H (Hsp110) member 1 "GO:0000774,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0006898,GO:0006986,GO:0032991,GO:0043014,GO:0045345,GO:0050790,GO:0051085,GO:0051135,GO:0070062,GO:0071682,GO:1900034" adenyl-nucleotide exchange factor activity|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|microtubule|receptor-mediated endocytosis|response to unfolded protein|protein-containing complex|alpha-tubulin binding|positive regulation of MHC class I biosynthetic process|regulation of catalytic activity|chaperone cofactor-dependent protein refolding|positive regulation of NK T cell activation|extracellular exosome|endocytic vesicle lumen|regulation of cellular response to heat hsa04141 Protein processing in endoplasmic reticulum HTATIP2 878.2330826 866.772397 889.6937681 1.02644451 0.037655637 0.92004184 1 19.91786031 21.32524788 10553 HIV-1 Tat interactive protein 2 "GO:0001525,GO:0003713,GO:0004674,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0006357,GO:0006915,GO:0016020,GO:0016032,GO:0016491,GO:0030154,GO:0043066,GO:0043068,GO:0045765,GO:0045944,GO:0046777,GO:0051170,GO:0055114" angiogenesis|transcription coactivator activity|protein serine/threonine kinase activity|protein binding|nucleus|nuclear envelope|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|apoptotic process|membrane|viral process|oxidoreductase activity|cell differentiation|negative regulation of apoptotic process|positive regulation of programmed cell death|regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|import into nucleus|oxidation-reduction process HTATSF1 1447.019156 1358.011086 1536.027225 1.131085925 0.177708531 0.594391927 1 23.65960465 27.91380314 27336 HIV-1 Tat specific factor 1 "GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005684,GO:0005686,GO:0006357,GO:0019079,GO:0032784" "mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|U2-type spliceosomal complex|U2 snRNP|regulation of transcription by RNA polymerase II|viral genome replication|regulation of DNA-templated transcription, elongation" HTR1B 10.44919681 7.104691779 13.79370183 1.941491941 0.957165719 0.512511229 1 0.140119772 0.283759849 3351 5-hydroxytryptamine receptor 1B "GO:0002031,GO:0004993,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007193,GO:0007198,GO:0007205,GO:0007268,GO:0008144,GO:0014053,GO:0014059,GO:0014063,GO:0030425,GO:0030594,GO:0032229,GO:0035690,GO:0042220,GO:0042310,GO:0042756,GO:0044305,GO:0045471,GO:0046849,GO:0050795,GO:0051378,GO:0051385,GO:0051967,GO:0071312,GO:0071502,GO:0098666,GO:0099056,GO:0099154,GO:0099171,GO:0099509,GO:0099626,GO:1904707,GO:2000300" "G protein-coupled receptor internalization|G protein-coupled serotonin receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting serotonin receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|chemical synaptic transmission|drug binding|negative regulation of gamma-aminobutyric acid secretion|regulation of dopamine secretion|negative regulation of serotonin secretion|dendrite|neurotransmitter receptor activity|negative regulation of synaptic transmission, GABAergic|cellular response to drug|response to cocaine|vasoconstriction|drinking behavior|calyx of Held|response to ethanol|bone remodeling|regulation of behavior|serotonin binding|response to mineralocorticoid|negative regulation of synaptic transmission, glutamatergic|cellular response to alkaloid|cellular response to temperature stimulus|G protein-coupled serotonin receptor complex|integral component of presynaptic membrane|serotonergic synapse|presynaptic modulation of chemical synaptic transmission|regulation of presynaptic cytosolic calcium ion concentration|voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels|positive regulation of vascular associated smooth muscle cell proliferation|regulation of synaptic vesicle exocytosis" "hsa04024,hsa04080,hsa04726,hsa04742" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction HTR1D 24.01749039 25.37389921 22.66108158 0.893086293 -0.163128515 0.916550668 1 0.387194481 0.360693662 3352 5-hydroxytryptamine receptor 1D "GO:0004993,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007193,GO:0007198,GO:0007268,GO:0014827,GO:0030425,GO:0030594,GO:0040012,GO:0042310,GO:0045202,GO:0050795,GO:0051378" "G protein-coupled serotonin receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting serotonin receptor signaling pathway|chemical synaptic transmission|intestine smooth muscle contraction|dendrite|neurotransmitter receptor activity|regulation of locomotion|vasoconstriction|synapse|regulation of behavior|serotonin binding" "hsa04024,hsa04080,hsa04726,hsa04742" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction HTR1F 6.926542468 2.029911937 11.823173 5.824475823 2.542128219 0.148475706 1 0.027592023 0.167631767 3355 5-hydroxytryptamine receptor 1F "GO:0004993,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007193,GO:0007198,GO:0007268,GO:0030425,GO:0030594,GO:0045202,GO:0051378" "G protein-coupled serotonin receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting serotonin receptor signaling pathway|chemical synaptic transmission|dendrite|neurotransmitter receptor activity|synapse|serotonin binding" "hsa04024,hsa04080,hsa04726,hsa04742" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction HTR7 183.4210012 213.1407534 153.701249 0.721125578 -0.47167758 0.39643648 1 1.919762981 1.444024104 3363 5-hydroxytryptamine receptor 7 "GO:0004993,GO:0005515,GO:0005886,GO:0005887,GO:0006939,GO:0007186,GO:0007187,GO:0007268,GO:0007623,GO:0008015,GO:0030425,GO:0030594,GO:0042310,GO:0045202,GO:0098664" "G protein-coupled serotonin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|smooth muscle contraction|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|chemical synaptic transmission|circadian rhythm|blood circulation|dendrite|neurotransmitter receptor activity|vasoconstriction|synapse|G protein-coupled serotonin receptor signaling pathway" "hsa04014,hsa04020,hsa04080,hsa04726" Ras signaling pathway|Calcium signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse HTRA1 228.6865028 175.5873825 281.7856231 1.604817038 0.682408828 0.186553122 1 4.252932324 7.119179254 5654 HtrA serine peptidase 1 "GO:0001890,GO:0004252,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0006508,GO:0008236,GO:0022617,GO:0030512,GO:0030514,GO:0042802,GO:0050679,GO:0050687,GO:0060718,GO:0062023,GO:0070062,GO:0097187" placenta development|serine-type endopeptidase activity|protein binding|insulin-like growth factor binding|extracellular region|extracellular space|cytosol|plasma membrane|proteolysis|serine-type peptidase activity|extracellular matrix disassembly|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|identical protein binding|positive regulation of epithelial cell proliferation|negative regulation of defense response to virus|chorionic trophoblast cell differentiation|collagen-containing extracellular matrix|extracellular exosome|dentinogenesis HTRA2 681.3180167 640.437216 722.1988173 1.127665287 0.173338912 0.650165191 1 13.84374121 16.28356957 27429 HtrA serine peptidase 2 "GO:0000785,GO:0004252,GO:0005515,GO:0005634,GO:0005739,GO:0005758,GO:0005783,GO:0005789,GO:0005829,GO:0005856,GO:0006508,GO:0006672,GO:0007005,GO:0007568,GO:0007628,GO:0008233,GO:0008236,GO:0008630,GO:0009635,GO:0009898,GO:0010822,GO:0012501,GO:0016020,GO:0016540,GO:0019742,GO:0030900,GO:0031966,GO:0034599,GO:0034605,GO:0035458,GO:0035631,GO:0040014,GO:0042802,GO:0043065,GO:0043280,GO:0044257,GO:0045786,GO:0048666,GO:0051082,GO:0071300,GO:0071363,GO:0097194,GO:1901215,GO:1902176,GO:1903146,GO:1903955,GO:1904924,GO:1905370,GO:2001241,GO:2001269" chromatin|serine-type endopeptidase activity|protein binding|nucleus|mitochondrion|mitochondrial intermembrane space|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|cytoskeleton|proteolysis|ceramide metabolic process|mitochondrion organization|aging|adult walking behavior|peptidase activity|serine-type peptidase activity|intrinsic apoptotic signaling pathway in response to DNA damage|response to herbicide|cytoplasmic side of plasma membrane|positive regulation of mitochondrion organization|programmed cell death|membrane|protein autoprocessing|pentacyclic triterpenoid metabolic process|forebrain development|mitochondrial membrane|cellular response to oxidative stress|cellular response to heat|cellular response to interferon-beta|CD40 receptor complex|regulation of multicellular organism growth|identical protein binding|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|cellular protein catabolic process|negative regulation of cell cycle|neuron development|unfolded protein binding|cellular response to retinoic acid|cellular response to growth factor stimulus|execution phase of apoptosis|negative regulation of neuron death|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|negative regulation of mitophagy in response to mitochondrial depolarization|serine-type endopeptidase complex|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway "hsa04210,hsa04215,hsa05012,hsa05022" Apoptosis|Apoptosis - multiple species|Parkinson disease|Pathways of neurodegeneration - multiple diseases HTRA3 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.076131427 0.030835109 94031 HtrA serine peptidase 3 "GO:0004175,GO:0004252,GO:0005515,GO:0005520,GO:0005576,GO:0006508,GO:0008236,GO:0030512,GO:0030514,GO:0042802" endopeptidase activity|serine-type endopeptidase activity|protein binding|insulin-like growth factor binding|extracellular region|proteolysis|serine-type peptidase activity|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|identical protein binding HTT 2984.660865 2983.970547 2985.351182 1.000462684 0.000667357 0.999538381 1 11.21790242 11.70653808 3064 huntingtin "GO:0000132,GO:0002039,GO:0005515,GO:0005522,GO:0005634,GO:0005654,GO:0005737,GO:0005769,GO:0005770,GO:0005776,GO:0005783,GO:0005794,GO:0005814,GO:0005829,GO:0006890,GO:0006915,GO:0007030,GO:0016234,GO:0019900,GO:0030424,GO:0030425,GO:0030659,GO:0031072,GO:0031587,GO:0031648,GO:0032991,GO:0034452,GO:0042297,GO:0042802,GO:0043065,GO:0043666,GO:0044325,GO:0045505,GO:0045724,GO:0047496,GO:0048471,GO:0048487,GO:0099111,GO:0099523,GO:0099524,GO:1903599,GO:1904504,GO:1905289,GO:1905337,GO:2000479,GO:2001237" "establishment of mitotic spindle orientation|p53 binding|protein binding|profilin binding|nucleus|nucleoplasm|cytoplasm|early endosome|late endosome|autophagosome|endoplasmic reticulum|Golgi apparatus|centriole|cytosol|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|apoptotic process|Golgi organization|inclusion body|kinase binding|axon|dendrite|cytoplasmic vesicle membrane|heat shock protein binding|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|protein destabilization|protein-containing complex|dynactin binding|vocal learning|identical protein binding|positive regulation of apoptotic process|regulation of phosphoprotein phosphatase activity|ion channel binding|dynein intermediate chain binding|positive regulation of cilium assembly|vesicle transport along microtubule|perinuclear region of cytoplasm|beta-tubulin binding|microtubule-based transport|presynaptic cytosol|postsynaptic cytosol|positive regulation of autophagy of mitochondrion|positive regulation of lipophagy|regulation of CAMKK-AMPK signaling cascade|positive regulation of aggrephagy|regulation of cAMP-dependent protein kinase activity|negative regulation of extrinsic apoptotic signaling pathway" "hsa05016,hsa05022" Huntington disease|Pathways of neurodegeneration - multiple diseases HUS1 380.0715647 387.7131799 372.4299495 0.960581091 -0.058020685 0.900950926 1 6.406624729 6.419175491 3364 HUS1 checkpoint clamp component "GO:0000077,GO:0000723,GO:0000724,GO:0001932,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006260,GO:0006281,GO:0006289,GO:0006468,GO:0006974,GO:0009411,GO:0009792,GO:0030896,GO:0031573,GO:0033314,GO:0035861,GO:0044778,GO:0071479,GO:1901796" DNA damage checkpoint|telomere maintenance|double-strand break repair via homologous recombination|regulation of protein phosphorylation|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA replication|DNA repair|nucleotide-excision repair|protein phosphorylation|cellular response to DNA damage stimulus|response to UV|embryo development ending in birth or egg hatching|checkpoint clamp complex|intra-S DNA damage checkpoint|mitotic DNA replication checkpoint|site of double-strand break|meiotic DNA integrity checkpoint|cellular response to ionizing radiation|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence HUWE1 15110.86309 15651.63599 14570.09019 0.930898866 -0.103303655 0.768393058 1 41.99735879 40.77936037 10075 "HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1" "GO:0000139,GO:0000209,GO:0003677,GO:0003723,GO:0004842,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006284,GO:0006513,GO:0007030,GO:0010637,GO:0016020,GO:0016567,GO:0016574,GO:0030154,GO:0031398,GO:0032922,GO:0034774,GO:0043161,GO:0043312,GO:0045732,GO:0061025,GO:0061630,GO:0070062,GO:0098779,GO:1903955,GO:1904813" Golgi membrane|protein polyubiquitination|DNA binding|RNA binding|ubiquitin-protein transferase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|base-excision repair|protein monoubiquitination|Golgi organization|negative regulation of mitochondrial fusion|membrane|protein ubiquitination|histone ubiquitination|cell differentiation|positive regulation of protein ubiquitination|circadian regulation of gene expression|secretory granule lumen|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|positive regulation of protein catabolic process|membrane fusion|ubiquitin protein ligase activity|extracellular exosome|positive regulation of mitophagy in response to mitochondrial depolarization|positive regulation of protein targeting to mitochondrion|ficolin-1-rich granule lumen hsa04120 Ubiquitin mediated proteolysis HVCN1 17.89806303 11.16451565 24.63161041 2.206240842 1.14159029 0.329824986 1 0.224739003 0.517186643 84329 hydrogen voltage gated channel 1 "GO:0005886,GO:0005887,GO:0009268,GO:0010043,GO:0016021,GO:0016324,GO:0022843,GO:0030171,GO:0030667,GO:0030670,GO:0032930,GO:0034765,GO:0035036,GO:0035579,GO:0042802,GO:0043312,GO:0045454,GO:0051453,GO:0071294,GO:0071467,GO:1902600" plasma membrane|integral component of plasma membrane|response to pH|response to zinc ion|integral component of membrane|apical plasma membrane|voltage-gated cation channel activity|voltage-gated proton channel activity|secretory granule membrane|phagocytic vesicle membrane|positive regulation of superoxide anion generation|regulation of ion transmembrane transport|sperm-egg recognition|specific granule membrane|identical protein binding|neutrophil degranulation|cell redox homeostasis|regulation of intracellular pH|cellular response to zinc ion|cellular response to pH|proton transmembrane transport HYAL1 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.017089076 0.051911234 3373 hyaluronidase 1 "GO:0000302,GO:0001618,GO:0004415,GO:0005615,GO:0005737,GO:0005764,GO:0005975,GO:0006954,GO:0008134,GO:0009615,GO:0010634,GO:0030207,GO:0030212,GO:0030213,GO:0030214,GO:0030307,GO:0030308,GO:0031410,GO:0036117,GO:0036120,GO:0043202,GO:0044344,GO:0045766,GO:0045785,GO:0045927,GO:0046677,GO:0046718,GO:0050501,GO:0050679,GO:0051216,GO:0060272,GO:0070062,GO:0071347,GO:0071356,GO:0071467,GO:0071493,GO:1900087,GO:1900106" response to reactive oxygen species|virus receptor activity|hyalurononglucosaminidase activity|extracellular space|cytoplasm|lysosome|carbohydrate metabolic process|inflammatory response|transcription factor binding|response to virus|positive regulation of epithelial cell migration|chondroitin sulfate catabolic process|hyaluronan metabolic process|hyaluronan biosynthetic process|hyaluronan catabolic process|positive regulation of cell growth|negative regulation of cell growth|cytoplasmic vesicle|hyaluranon cable|cellular response to platelet-derived growth factor stimulus|lysosomal lumen|cellular response to fibroblast growth factor stimulus|positive regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of growth|response to antibiotic|viral entry into host cell|hyaluronan synthase activity|positive regulation of epithelial cell proliferation|cartilage development|embryonic skeletal joint morphogenesis|extracellular exosome|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to pH|cellular response to UV-B|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of hyaluranon cable assembly "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome HYAL2 1098.739071 1224.036898 973.4412435 0.79527116 -0.330481242 0.340889928 1 23.5536287 19.5383996 8692 hyaluronidase 2 "GO:0000139,GO:0000302,GO:0001618,GO:0001822,GO:0002244,GO:0003713,GO:0004415,GO:0005515,GO:0005540,GO:0005737,GO:0005764,GO:0005783,GO:0005829,GO:0005886,GO:0005902,GO:0005975,GO:0006027,GO:0009615,GO:0009986,GO:0010259,GO:0010764,GO:0016324,GO:0019064,GO:0019087,GO:0019899,GO:0030139,GO:0030214,GO:0030294,GO:0030308,GO:0030971,GO:0031362,GO:0031410,GO:0032755,GO:0032757,GO:0033906,GO:0035810,GO:0042117,GO:0042307,GO:0043407,GO:0044344,GO:0045121,GO:0045944,GO:0046658,GO:0046677,GO:0046718,GO:0048471,GO:0048705,GO:0050431,GO:0050729,GO:0051216,GO:0051607,GO:0051898,GO:0060586,GO:0061099,GO:0070295,GO:0071347,GO:0071356,GO:0071493,GO:0071560,GO:0090575,GO:2001238" Golgi membrane|response to reactive oxygen species|virus receptor activity|kidney development|hematopoietic progenitor cell differentiation|transcription coactivator activity|hyalurononglucosaminidase activity|protein binding|hyaluronic acid binding|cytoplasm|lysosome|endoplasmic reticulum|cytosol|plasma membrane|microvillus|carbohydrate metabolic process|glycosaminoglycan catabolic process|response to virus|cell surface|multicellular organism aging|negative regulation of fibroblast migration|apical plasma membrane|fusion of virus membrane with host plasma membrane|transformation of host cell by virus|enzyme binding|endocytic vesicle|hyaluronan catabolic process|receptor signaling protein tyrosine kinase inhibitor activity|negative regulation of cell growth|receptor tyrosine kinase binding|anchored component of external side of plasma membrane|cytoplasmic vesicle|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|hyaluronoglucuronidase activity|positive regulation of urine volume|monocyte activation|positive regulation of protein import into nucleus|negative regulation of MAP kinase activity|cellular response to fibroblast growth factor stimulus|membrane raft|positive regulation of transcription by RNA polymerase II|anchored component of plasma membrane|response to antibiotic|viral entry into host cell|perinuclear region of cytoplasm|skeletal system morphogenesis|transforming growth factor beta binding|positive regulation of inflammatory response|cartilage development|defense response to virus|negative regulation of protein kinase B signaling|multicellular organismal iron ion homeostasis|negative regulation of protein tyrosine kinase activity|renal water absorption|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to UV-B|cellular response to transforming growth factor beta stimulus|RNA polymerase II transcription regulator complex|positive regulation of extrinsic apoptotic signaling pathway "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome HYAL3 468.7426406 421.2067269 516.2785543 1.225712984 0.293621194 0.48096359 1 11.12233305 14.22003325 8372 hyaluronidase 3 "GO:0001552,GO:0001618,GO:0001669,GO:0002080,GO:0004415,GO:0005515,GO:0005576,GO:0005764,GO:0005769,GO:0005783,GO:0005886,GO:0005975,GO:0006954,GO:0007341,GO:0009615,GO:0030214,GO:0031410,GO:0033906,GO:0046677,GO:0046718,GO:0051216,GO:0071347,GO:0071356,GO:0071493,GO:0097225,GO:2000355,GO:2000368" ovarian follicle atresia|virus receptor activity|acrosomal vesicle|acrosomal membrane|hyalurononglucosaminidase activity|protein binding|extracellular region|lysosome|early endosome|endoplasmic reticulum|plasma membrane|carbohydrate metabolic process|inflammatory response|penetration of zona pellucida|response to virus|hyaluronan catabolic process|cytoplasmic vesicle|hyaluronoglucuronidase activity|response to antibiotic|viral entry into host cell|cartilage development|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to UV-B|sperm midpiece|negative regulation of ovarian follicle development|positive regulation of acrosomal vesicle exocytosis "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome HYI 1104.494281 943.9090506 1265.079511 1.340255727 0.4225083 0.222962563 1 28.03851232 39.19751801 81888 hydroxypyruvate isomerase (putative) "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0008903,GO:0046487" molecular_function|protein binding|cellular_component|biological_process|hydroxypyruvate isomerase activity|glyoxylate metabolic process hsa00630 Glyoxylate and dicarboxylate metabolism HYKK 129.5244144 98.45072893 160.5980999 1.631253538 0.705981031 0.25733622 1 1.167450739 1.986442328 123688 hydroxylysine kinase "GO:0005759,GO:0006554,GO:0016310,GO:0019202,GO:0047992" mitochondrial matrix|lysine catabolic process|phosphorylation|amino acid kinase activity|hydroxylysine kinase activity hsa00310 Lysine degradation HYLS1 350.2370057 301.4419226 399.0320887 1.323744505 0.404624696 0.370301561 1 6.821702394 9.419175068 219844 HYLS1 centriolar and ciliogenesis associated "GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0060271,GO:0097730" protein binding|nucleus|cytoplasm|centrosome|centriole|cytosol|plasma membrane|cilium|cilium assembly|non-motile cilium HYOU1 8382.534675 8884.924547 7880.144804 0.886911843 -0.173137384 0.601792202 1 95.05493962 87.93688431 10525 hypoxia up-regulated 1 "GO:0000774,GO:0002931,GO:0005515,GO:0005524,GO:0005576,GO:0005783,GO:0005788,GO:0005790,GO:0005925,GO:0006888,GO:0006898,GO:0016020,GO:0034663,GO:0034976,GO:0036498,GO:0050790,GO:0051082,GO:0051087,GO:0070062,GO:0071456,GO:0071682,GO:1903298" adenyl-nucleotide exchange factor activity|response to ischemia|protein binding|ATP binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|smooth endoplasmic reticulum|focal adhesion|endoplasmic reticulum to Golgi vesicle-mediated transport|receptor-mediated endocytosis|membrane|endoplasmic reticulum chaperone complex|response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|regulation of catalytic activity|unfolded protein binding|chaperone binding|extracellular exosome|cellular response to hypoxia|endocytic vesicle lumen|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum HYPK 472.3610505 533.8668394 410.8552617 0.769583783 -0.377849697 0.362619888 1 8.478667935 6.806117832 25764 huntingtin interacting protein K "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0015630,GO:0032991,GO:0043066,GO:0047485,GO:0050821" protein binding|nucleus|nucleoplasm|cytoplasm|microtubule cytoskeleton|protein-containing complex|negative regulation of apoptotic process|protein N-terminus binding|protein stabilization IAH1 664.0071037 568.3753423 759.6388652 1.336509184 0.418469752 0.273631836 1 14.68683979 20.47463812 285148 isoamyl acetate hydrolyzing esterase 1 (putative) "GO:0016042,GO:0016787,GO:0042802" lipid catabolic process|hydrolase activity|identical protein binding IARS1 4974.934087 5074.779842 4875.088333 0.960650212 -0.057916876 0.857320485 1 53.51232485 53.6210152 3376 isoleucyl-tRNA synthetase 1 "GO:0000049,GO:0001649,GO:0002161,GO:0004822,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006418,GO:0006428,GO:0016020,GO:0017101,GO:0051020,GO:0070062,GO:0106074" tRNA binding|osteoblast differentiation|aminoacyl-tRNA editing activity|isoleucine-tRNA ligase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cytosol|tRNA aminoacylation for protein translation|isoleucyl-tRNA aminoacylation|membrane|aminoacyl-tRNA synthetase multienzyme complex|GTPase binding|extracellular exosome|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis IARS2 4113.458665 4107.526804 4119.390526 1.002888288 0.004160913 0.990451276 1 58.93250485 61.64862435 55699 "isoleucyl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0002161,GO:0004822,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006428,GO:0032543,GO:0106074" tRNA binding|aminoacyl-tRNA editing activity|isoleucine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|isoleucyl-tRNA aminoacylation|mitochondrial translation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis IBA57 245.4575247 278.0979353 212.817114 0.765259597 -0.385978862 0.445720601 1 1.789894441 1.42873648 200205 iron-sulfur cluster assembly factor IBA57 "GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0006783,GO:0016226,GO:0016740" RNA binding|protein binding|mitochondrion|mitochondrial matrix|heme biosynthetic process|iron-sulfur cluster assembly|transferase activity IBTK 1187.554645 1132.690861 1242.418429 1.096873359 0.133396967 0.698395437 1 9.303729517 10.64460362 25998 inhibitor of Bruton tyrosine kinase "GO:0001933,GO:0005654,GO:0005737,GO:0016020,GO:0019901,GO:0030292,GO:0051209,GO:0061099" negative regulation of protein phosphorylation|nucleoplasm|cytoplasm|membrane|protein kinase binding|protein tyrosine kinase inhibitor activity|release of sequestered calcium ion into cytosol|negative regulation of protein tyrosine kinase activity ICA1 159.121441 168.4826908 149.7601913 0.888875828 -0.169946199 0.778025175 1 2.787668708 2.584628841 3382 islet cell autoantigen 1 "GO:0000139,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0006836,GO:0019904,GO:0030667,GO:0030672,GO:0043231,GO:0050796,GO:0051049,GO:0140090" Golgi membrane|protein binding|cytoplasm|Golgi apparatus|cytosol|neurotransmitter transport|protein domain specific binding|secretory granule membrane|synaptic vesicle membrane|intracellular membrane-bounded organelle|regulation of insulin secretion|regulation of transport|membrane curvature sensor activity hsa04940 Type I diabetes mellitus ICA1L 99.25116307 83.22638941 115.2759367 1.385088763 0.469978434 0.493429947 1 0.482389908 0.696934156 130026 islet cell autoantigen 1 like "GO:0005515,GO:0005794,GO:0019904,GO:0051049" protein binding|Golgi apparatus|protein domain specific binding|regulation of transport ICAM1 5980.165081 5900.954 6059.376162 1.026846873 0.038221058 0.906640249 1 100.7288516 107.888585 3383 intercellular adhesion molecule 1 "GO:0001541,GO:0001618,GO:0001772,GO:0001910,GO:0001975,GO:0002291,GO:0002438,GO:0002457,GO:0002693,GO:0004888,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007157,GO:0007159,GO:0007569,GO:0007605,GO:0008360,GO:0009897,GO:0009986,GO:0010212,GO:0010477,GO:0016020,GO:0019221,GO:0022614,GO:0030198,GO:0030838,GO:0031669,GO:0032868,GO:0033627,GO:0034698,GO:0038023,GO:0042493,GO:0043200,GO:0043547,GO:0044406,GO:0045121,GO:0045429,GO:0045471,GO:0045907,GO:0046688,GO:0046718,GO:0046813,GO:0050731,GO:0050776,GO:0050900,GO:0051092,GO:0051926,GO:0060333,GO:0061028,GO:0062023,GO:0070062,GO:0070374,GO:0071222,GO:0071312,GO:0071333,GO:0071347,GO:0071354,GO:0071356,GO:0071456,GO:0071549,GO:0072683,GO:0090557,GO:0097368,GO:1900027,GO:1902042,GO:1904646,GO:1904996,GO:1990830,GO:2000352" ovarian follicle development|virus receptor activity|immunological synapse|regulation of leukocyte mediated cytotoxicity|response to amphetamine|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|acute inflammatory response to antigenic stimulus|T cell antigen processing and presentation|positive regulation of cellular extravasation|transmembrane signaling receptor activity|integrin binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|leukocyte cell-cell adhesion|cell aging|sensory perception of sound|regulation of cell shape|external side of plasma membrane|cell surface|response to ionizing radiation|response to sulfur dioxide|membrane|cytokine-mediated signaling pathway|membrane to membrane docking|extracellular matrix organization|positive regulation of actin filament polymerization|cellular response to nutrient levels|response to insulin|cell adhesion mediated by integrin|response to gonadotropin|signaling receptor activity|response to drug|response to amino acid|positive regulation of GTPase activity|adhesion of symbiont to host|membrane raft|positive regulation of nitric oxide biosynthetic process|response to ethanol|positive regulation of vasoconstriction|response to copper ion|viral entry into host cell|receptor-mediated virion attachment to host cell|positive regulation of peptidyl-tyrosine phosphorylation|regulation of immune response|leukocyte migration|positive regulation of NF-kappaB transcription factor activity|negative regulation of calcium ion transport|interferon-gamma-mediated signaling pathway|establishment of endothelial barrier|collagen-containing extracellular matrix|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|cellular response to alkaloid|cellular response to glucose stimulus|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to hypoxia|cellular response to dexamethasone stimulus|T cell extravasation|establishment of endothelial intestinal barrier|establishment of Sertoli cell barrier|regulation of ruffle assembly|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|cellular response to amyloid-beta|positive regulation of leukocyte adhesion to vascular endothelial cell|cellular response to leukemia inhibitory factor|negative regulation of endothelial cell apoptotic process "hsa04064,hsa04514,hsa04650,hsa04668,hsa04670,hsa04933,hsa05143,hsa05144,hsa05150,hsa05164,hsa05166,hsa05167,hsa05169,hsa05323,hsa05416,hsa05418" NF-kappa B signaling pathway|Cell adhesion molecules|Natural killer cell mediated cytotoxicity|TNF signaling pathway|Leukocyte transendothelial migration|AGE-RAGE signaling pathway in diabetic complications|African trypanosomiasis|Malaria|Staphylococcus aureus infection|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Rheumatoid arthritis|Viral myocarditis|Fluid shear stress and atherosclerosis ICAM2 95.35464273 86.27125731 104.4380282 1.210577328 0.275695237 0.698202669 1 3.210385625 4.053831266 3384 intercellular adhesion molecule 2 "GO:0001931,GO:0002223,GO:0005178,GO:0005886,GO:0005887,GO:0005902,GO:0007155,GO:0016020,GO:0030198,GO:0032154,GO:0050776,GO:0098609" uropod|stimulatory C-type lectin receptor signaling pathway|integrin binding|plasma membrane|integral component of plasma membrane|microvillus|cell adhesion|membrane|extracellular matrix organization|cleavage furrow|regulation of immune response|cell-cell adhesion "hsa04514,hsa04650" Cell adhesion molecules|Natural killer cell mediated cytotoxicity ICAM3 122.310359 144.1237475 100.4969705 0.697296401 -0.520156059 0.414212825 1 3.592204416 2.612729182 3385 intercellular adhesion molecule 3 "GO:0002223,GO:0005102,GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0006909,GO:0007155,GO:0030198,GO:0050776,GO:0070062,GO:0098609" stimulatory C-type lectin receptor signaling pathway|signaling receptor binding|integrin binding|protein binding|plasma membrane|integral component of plasma membrane|phagocytosis|cell adhesion|extracellular matrix organization|regulation of immune response|extracellular exosome|cell-cell adhesion hsa04514 Cell adhesion molecules ICAM4 3.552345889 7.104691779 0 0 #NAME? 0.089820349 1 0.278936104 0 3386 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) "GO:0005178,GO:0005576,GO:0005886,GO:0005887,GO:0007155,GO:0016021,GO:0030198,GO:0050776,GO:0098609" integrin binding|extracellular region|plasma membrane|integral component of plasma membrane|cell adhesion|integral component of membrane|extracellular matrix organization|regulation of immune response|cell-cell adhesion ICAM5 176.9870909 211.1108414 142.8633404 0.676721951 -0.563364909 0.316107892 1 3.44016067 2.428314426 7087 intercellular adhesion molecule 5 "GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0006909,GO:0007155,GO:0030198,GO:0050776,GO:0098609" integrin binding|protein binding|plasma membrane|integral component of plasma membrane|phagocytosis|cell adhesion|extracellular matrix organization|regulation of immune response|cell-cell adhesion ICE1 2649.799378 2689.633316 2609.965439 0.970379651 -0.043378797 0.892806966 1 16.52960066 16.73092576 23379 interactor of little elongation complex ELL subunit 1 "GO:0005515,GO:0005654,GO:0008023,GO:0015030,GO:0016604,GO:0030674,GO:0031334,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0045945,GO:0090316" protein binding|nucleoplasm|transcription elongation factor complex|Cajal body|nuclear body|protein-macromolecule adaptor activity|positive regulation of protein-containing complex assembly|transcriptionally active chromatin|histone locus body|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III|positive regulation of transcription by RNA polymerase III|positive regulation of intracellular protein transport other ICE2 733.875762 697.2747503 770.4767737 1.104983041 0.144024227 0.702286556 1 3.609413968 4.160142786 79664 interactor of little elongation complex ELL subunit 2 "GO:0005515,GO:0005654,GO:0005829,GO:0008023,GO:0015030,GO:0016604,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0045945" protein binding|nucleoplasm|cytosol|transcription elongation factor complex|Cajal body|nuclear body|transcriptionally active chromatin|histone locus body|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III|positive regulation of transcription by RNA polymerase III other ICMT 3485.292224 3564.525361 3406.059088 0.955543514 -0.065606523 0.837306162 1 37.20746798 37.08484902 23463 isoprenylcysteine carboxyl methyltransferase "GO:0003880,GO:0004671,GO:0005515,GO:0005783,GO:0005789,GO:0006464,GO:0006481,GO:0006612,GO:0016020,GO:0016021,GO:0043687" protein C-terminal carboxyl O-methyltransferase activity|protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cellular protein modification process|C-terminal protein methylation|protein targeting to membrane|membrane|integral component of membrane|post-translational protein modification hsa00900 Terpenoid backbone biosynthesis ICOSLG 20.74721425 37.55337083 3.941057666 0.10494551 -3.252287647 0.008406017 0.382332731 0.203525495 0.02227915 23308 inducible T cell costimulator ligand "GO:0001817,GO:0002250,GO:0005102,GO:0005515,GO:0005886,GO:0006952,GO:0006972,GO:0007165,GO:0009897,GO:0016021,GO:0031295,GO:0036464,GO:0042104,GO:0042110,GO:0042113,GO:0042802,GO:0050852,GO:0070062" regulation of cytokine production|adaptive immune response|signaling receptor binding|protein binding|plasma membrane|defense response|hyperosmotic response|signal transduction|external side of plasma membrane|integral component of membrane|T cell costimulation|cytoplasmic ribonucleoprotein granule|positive regulation of activated T cell proliferation|T cell activation|B cell activation|identical protein binding|T cell receptor signaling pathway|extracellular exosome "hsa04514,hsa04672" Cell adhesion molecules|Intestinal immune network for IgA production ID1 524.2467766 410.0422112 638.4513419 1.557038091 0.638804239 0.11408375 1 21.12633922 34.31147719 3397 "inhibitor of DNA binding 1, HLH protein" "GO:0000122,GO:0001525,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005813,GO:0007179,GO:0007420,GO:0008022,GO:0008134,GO:0010621,GO:0010628,GO:0030154,GO:0030182,GO:0032091,GO:0032233,GO:0032922,GO:0036164,GO:0042802,GO:0043066,GO:0043392,GO:0043433,GO:0043534,GO:0045602,GO:0045892,GO:0046983,GO:0047485,GO:0048514,GO:0050679,GO:0050774,GO:0070628,GO:0071364,GO:0120163,GO:0140110,GO:0140416,GO:1901342,GO:1901653,GO:1903351,GO:1990090" "negative regulation of transcription by RNA polymerase II|angiogenesis|protein binding|nucleus|nucleoplasm|Golgi apparatus|centrosome|transforming growth factor beta receptor signaling pathway|brain development|protein C-terminus binding|transcription factor binding|negative regulation of transcription by transcription factor localization|positive regulation of gene expression|cell differentiation|neuron differentiation|negative regulation of protein binding|positive regulation of actin filament bundle assembly|circadian regulation of gene expression|cell-abiotic substrate adhesion|identical protein binding|negative regulation of apoptotic process|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|blood vessel endothelial cell migration|negative regulation of endothelial cell differentiation|negative regulation of transcription, DNA-templated|protein dimerization activity|protein N-terminus binding|blood vessel morphogenesis|positive regulation of epithelial cell proliferation|negative regulation of dendrite morphogenesis|proteasome binding|cellular response to epidermal growth factor stimulus|negative regulation of cold-induced thermogenesis|transcription regulator activity|transcription regulator inhibitor activity|regulation of vasculature development|cellular response to peptide|cellular response to dopamine|cellular response to nerve growth factor stimulus" "hsa04015,hsa04350,hsa04390,hsa04550" Rap1 signaling pathway|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells ID2 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.158287727 0.160276101 3398 inhibitor of DNA binding 2 "GO:0000122,GO:0000791,GO:0001102,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0010628,GO:0010629,GO:0019216,GO:0030154,GO:0032922,GO:0032991,GO:0033598,GO:0042752,GO:0043153,GO:0043433,GO:0044325,GO:0045475,GO:0045664,GO:0045777,GO:0045892,GO:0045893,GO:0046983,GO:0048557,GO:0048661,GO:0048663,GO:0051148,GO:0060749,GO:0061030,GO:0061031,GO:0071158,GO:0071931,GO:0090398,GO:0140110,GO:0140416,GO:2000045,GO:2000177" "negative regulation of transcription by RNA polymerase II|euchromatin|RNA polymerase II activating transcription factor binding|protein binding|nucleus|cytoplasm|cytosol|positive regulation of gene expression|negative regulation of gene expression|regulation of lipid metabolic process|cell differentiation|circadian regulation of gene expression|protein-containing complex|mammary gland epithelial cell proliferation|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|negative regulation of DNA-binding transcription factor activity|ion channel binding|locomotor rhythm|regulation of neuron differentiation|positive regulation of blood pressure|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|embryonic digestive tract morphogenesis|positive regulation of smooth muscle cell proliferation|neuron fate commitment|negative regulation of muscle cell differentiation|mammary gland alveolus development|epithelial cell differentiation involved in mammary gland alveolus development|endodermal digestive tract morphogenesis|positive regulation of cell cycle arrest|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|cellular senescence|transcription regulator activity|transcription regulator inhibitor activity|regulation of G1/S transition of mitotic cell cycle|regulation of neural precursor cell proliferation" "hsa04350,hsa04390,hsa04550,hsa05202" TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer ID3 165.3623562 157.3181751 173.4065373 1.102266392 0.140472932 0.815238845 1 8.386958509 9.642885066 3399 "inhibitor of DNA binding 3, HLH protein" "GO:0000122,GO:0001656,GO:0005515,GO:0005634,GO:0005737,GO:0006275,GO:0007275,GO:0007417,GO:0007507,GO:0007517,GO:0008134,GO:0009611,GO:0010628,GO:0019904,GO:0030154,GO:0030182,GO:0030855,GO:0030903,GO:0032922,GO:0042476,GO:0043065,GO:0043433,GO:0045662,GO:0045668,GO:0045892,GO:0046983,GO:0051726,GO:0072750,GO:0140110,GO:0140416,GO:1901707" "negative regulation of transcription by RNA polymerase II|metanephros development|protein binding|nucleus|cytoplasm|regulation of DNA replication|multicellular organism development|central nervous system development|heart development|muscle organ development|transcription factor binding|response to wounding|positive regulation of gene expression|protein domain specific binding|cell differentiation|neuron differentiation|epithelial cell differentiation|notochord development|circadian regulation of gene expression|odontogenesis|positive regulation of apoptotic process|negative regulation of DNA-binding transcription factor activity|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|protein dimerization activity|regulation of cell cycle|cellular response to leptomycin B|transcription regulator activity|transcription regulator inhibitor activity|leptomycin B binding" "hsa04350,hsa04550" TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells bHLH IDE 3470.719615 3780.710982 3160.728248 0.836014248 -0.258400565 0.416740087 1 25.84419945 22.53682294 3416 insulin degrading enzyme "GO:0001540,GO:0001618,GO:0004175,GO:0004222,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006508,GO:0006625,GO:0008270,GO:0008286,GO:0008340,GO:0009897,GO:0009986,GO:0010815,GO:0010992,GO:0016323,GO:0016887,GO:0019885,GO:0030163,GO:0031597,GO:0031626,GO:0032092,GO:0042277,GO:0042447,GO:0042803,GO:0043171,GO:0043559,GO:0044257,GO:0044877,GO:0045732,GO:0045861,GO:0046718,GO:0050435,GO:0051603,GO:0070062,GO:0097242,GO:0140036,GO:0150094,GO:1901142,GO:1901143,GO:1903715" amyloid-beta binding|virus receptor activity|endopeptidase activity|metalloendopeptidase activity|protein binding|ATP binding|extracellular space|nucleus|cytoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|proteolysis|protein targeting to peroxisome|zinc ion binding|insulin receptor signaling pathway|determination of adult lifespan|external side of plasma membrane|cell surface|bradykinin catabolic process|ubiquitin recycling|basolateral plasma membrane|ATPase activity|antigen processing and presentation of endogenous peptide antigen via MHC class I|protein catabolic process|cytosolic proteasome complex|beta-endorphin binding|positive regulation of protein binding|peptide binding|hormone catabolic process|protein homodimerization activity|peptide catabolic process|insulin binding|cellular protein catabolic process|protein-containing complex binding|positive regulation of protein catabolic process|negative regulation of proteolysis|viral entry into host cell|amyloid-beta metabolic process|proteolysis involved in cellular protein catabolic process|extracellular exosome|amyloid-beta clearance|ubiquitin-dependent protein binding|amyloid-beta clearance by cellular catabolic process|insulin metabolic process|insulin catabolic process|regulation of aerobic respiration hsa05010 Alzheimer disease IDH1 1082.074691 1095.13749 1069.011892 0.976144002 -0.034834103 0.922878188 1 20.47428957 20.84676453 3417 isocitrate dehydrogenase (NADP(+)) 1 "GO:0000287,GO:0004450,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006097,GO:0006099,GO:0006102,GO:0006103,GO:0006625,GO:0006739,GO:0006740,GO:0006749,GO:0006979,GO:0008585,GO:0034774,GO:0042802,GO:0042803,GO:0043312,GO:0045296,GO:0048545,GO:0050661,GO:0051287,GO:0060696,GO:0070062,GO:0071071,GO:1904724,GO:1904813" magnesium ion binding|isocitrate dehydrogenase (NADP+) activity|protein binding|extracellular region|cytoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|glyoxylate cycle|tricarboxylic acid cycle|isocitrate metabolic process|2-oxoglutarate metabolic process|protein targeting to peroxisome|NADP metabolic process|NADPH regeneration|glutathione metabolic process|response to oxidative stress|female gonad development|secretory granule lumen|identical protein binding|protein homodimerization activity|neutrophil degranulation|cadherin binding|response to steroid hormone|NADP binding|NAD binding|regulation of phospholipid catabolic process|extracellular exosome|regulation of phospholipid biosynthetic process|tertiary granule lumen|ficolin-1-rich granule lumen "hsa00020,hsa00480,hsa04146,hsa05230" Citrate cycle (TCA cycle)|Glutathione metabolism|Peroxisome|Central carbon metabolism in cancer IDH2 2561.175561 2625.69109 2496.660032 0.950858249 -0.072697811 0.820592839 1 49.17973034 48.77731059 3418 isocitrate dehydrogenase (NADP(+)) 2 "GO:0000287,GO:0004450,GO:0005739,GO:0005759,GO:0005777,GO:0005829,GO:0005975,GO:0006097,GO:0006099,GO:0006102,GO:0006103,GO:0006739,GO:0006741,GO:0051287,GO:0060253,GO:0070062,GO:1903976,GO:1904465" magnesium ion binding|isocitrate dehydrogenase (NADP+) activity|mitochondrion|mitochondrial matrix|peroxisome|cytosol|carbohydrate metabolic process|glyoxylate cycle|tricarboxylic acid cycle|isocitrate metabolic process|2-oxoglutarate metabolic process|NADP metabolic process|NADP biosynthetic process|NAD binding|negative regulation of glial cell proliferation|extracellular exosome|negative regulation of glial cell migration|negative regulation of matrix metallopeptidase secretion "hsa00020,hsa00480,hsa04146,hsa05230" Citrate cycle (TCA cycle)|Glutathione metabolism|Peroxisome|Central carbon metabolism in cancer IDH3A 1707.325916 1506.194657 1908.457175 1.267072065 0.341498581 0.29601983 1 25.99095259 34.35100463 3419 isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha "GO:0000287,GO:0004449,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0005975,GO:0006099,GO:0006102,GO:0051287" magnesium ion binding|isocitrate dehydrogenase (NAD+) activity|protein binding|nucleus|mitochondrion|mitochondrial matrix|carbohydrate metabolic process|tricarboxylic acid cycle|isocitrate metabolic process|NAD binding hsa00020 Citrate cycle (TCA cycle) IDH3B 2928.595311 2923.073189 2934.117432 1.003778299 0.005440661 0.987565897 1 80.45833969 84.2412492 3420 isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta "GO:0000287,GO:0004449,GO:0005634,GO:0005739,GO:0005759,GO:0006099,GO:0006102,GO:0009055,GO:0022900,GO:0051287" magnesium ion binding|isocitrate dehydrogenase (NAD+) activity|nucleus|mitochondrion|mitochondrial matrix|tricarboxylic acid cycle|isocitrate metabolic process|electron transfer activity|electron transport chain|NAD binding hsa00020 Citrate cycle (TCA cycle) IDH3G 1533.475243 1644.228669 1422.721817 0.865282211 -0.208757352 0.528290396 1 52.93984843 47.78112803 3421 isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma "GO:0000287,GO:0004449,GO:0005515,GO:0005524,GO:0005730,GO:0005739,GO:0005759,GO:0005975,GO:0006099,GO:0006102,GO:0051287" magnesium ion binding|isocitrate dehydrogenase (NAD+) activity|protein binding|ATP binding|nucleolus|mitochondrion|mitochondrial matrix|carbohydrate metabolic process|tricarboxylic acid cycle|isocitrate metabolic process|NAD binding hsa00020 Citrate cycle (TCA cycle) IDI1 777.8887753 641.452172 914.3253786 1.425399147 0.511365966 0.166558582 1 5.436293441 8.082678702 3422 isopentenyl-diphosphate delta isomerase 1 "GO:0004452,GO:0005737,GO:0005777,GO:0005829,GO:0006695,GO:0009240,GO:0016787,GO:0045540,GO:0046872,GO:0050992" isopentenyl-diphosphate delta-isomerase activity|cytoplasm|peroxisome|cytosol|cholesterol biosynthetic process|isopentenyl diphosphate biosynthetic process|hydrolase activity|regulation of cholesterol biosynthetic process|metal ion binding|dimethylallyl diphosphate biosynthetic process hsa00900 Terpenoid backbone biosynthesis IDNK 67.76723907 86.27125731 49.26322083 0.571027041 -0.808369028 0.295604793 1 0.639726916 0.38103707 414328 IDNK gluconokinase "GO:0003674,GO:0005524,GO:0008150,GO:0016310,GO:0046177,GO:0046316" molecular_function|ATP binding|biological_process|phosphorylation|D-gluconate catabolic process|gluconokinase activity hsa00030 Pentose phosphate pathway IDO1 8.089956195 14.20938356 1.970528833 0.138677996 -2.850189203 0.088190553 1 0.389213169 0.056300339 3620 "indoleamine 2,3-dioxygenase 1" "GO:0002376,GO:0002666,GO:0002678,GO:0002830,GO:0004833,GO:0005737,GO:0005829,GO:0006569,GO:0006954,GO:0007565,GO:0009055,GO:0019441,GO:0020037,GO:0022900,GO:0030485,GO:0032421,GO:0032496,GO:0032693,GO:0032735,GO:0033555,GO:0033754,GO:0034276,GO:0034354,GO:0036269,GO:0042130,GO:0046006,GO:0046872,GO:0070233,GO:0070234" "immune system process|positive regulation of T cell tolerance induction|positive regulation of chronic inflammatory response|positive regulation of type 2 immune response|tryptophan 2,3-dioxygenase activity|cytoplasm|cytosol|tryptophan catabolic process|inflammatory response|female pregnancy|electron transfer activity|tryptophan catabolic process to kynurenine|heme binding|electron transport chain|smooth muscle contractile fiber|stereocilium bundle|response to lipopolysaccharide|negative regulation of interleukin-10 production|positive regulation of interleukin-12 production|multicellular organismal response to stress|indoleamine 2,3-dioxygenase activity|kynurenic acid biosynthetic process|'de novo' NAD biosynthetic process from tryptophan|swimming behavior|negative regulation of T cell proliferation|regulation of activated T cell proliferation|metal ion binding|negative regulation of T cell apoptotic process|positive regulation of T cell apoptotic process" "hsa00380,hsa05143" Tryptophan metabolism|African trypanosomiasis IDS 5211.213955 5129.587464 5292.840446 1.031825753 0.045199359 0.888794855 1 33.46586487 36.0183941 3423 iduronate 2-sulfatase "GO:0004423,GO:0005509,GO:0005764,GO:0006027,GO:0008484,GO:0030207,GO:0043202" iduronate-2-sulfatase activity|calcium ion binding|lysosome|glycosaminoglycan catabolic process|sulfuric ester hydrolase activity|chondroitin sulfate catabolic process|lysosomal lumen "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome IDUA 122.684225 136.0040998 109.3643502 0.804125393 -0.314507605 0.625644235 1 2.23495388 1.874598531 3425 alpha-L-iduronidase "GO:0003940,GO:0004553,GO:0005102,GO:0005984,GO:0006027,GO:0030135,GO:0030207,GO:0030209,GO:0030211,GO:0043202,GO:0070062" "L-iduronidase activity|hydrolase activity, hydrolyzing O-glycosyl compounds|signaling receptor binding|disaccharide metabolic process|glycosaminoglycan catabolic process|coated vesicle|chondroitin sulfate catabolic process|dermatan sulfate catabolic process|heparin catabolic process|lysosomal lumen|extracellular exosome" "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome IER2 1120.83057 1252.455665 989.2054742 0.789812767 -0.340417406 0.324985667 1 30.06277774 24.76675941 9592 immediate early response 2 "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0030182,GO:0045944,GO:0048870,GO:0071774" DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|neuron differentiation|positive regulation of transcription by RNA polymerase II|cell motility|response to fibroblast growth factor IER3 2273.895517 2452.13362 2095.657414 0.854626109 -0.226634703 0.478976038 1 100.3976695 89.49849208 8870 immediate early response 3 "GO:0005515,GO:0005634,GO:0005829,GO:0006915,GO:0009653,GO:0014066,GO:0016021,GO:0043066,GO:2001020" protein binding|nucleus|cytosol|apoptotic process|anatomical structure morphogenesis|regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|negative regulation of apoptotic process|regulation of response to DNA damage stimulus IER3IP1 1307.844741 970.2979058 1645.391576 1.695759174 0.761931298 0.024559138 0.693409464 13.35747918 23.62678401 51124 immediate early response 3 interacting protein 1 "GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006888,GO:0016020,GO:0030134,GO:0030173,GO:2000269" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|membrane|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|regulation of fibroblast apoptotic process IER5 1084.200605 836.3237179 1332.077491 1.592777369 0.671544628 0.053900246 1 10.08256271 16.75104626 51278 immediate early response 5 "GO:0000159,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0034605,GO:0042127,GO:0042802,GO:0045944,GO:1900036" protein phosphatase type 2A complex|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cellular response to heat|regulation of cell population proliferation|identical protein binding|positive regulation of transcription by RNA polymerase II|positive regulation of cellular response to heat IER5L 383.2149098 467.8947014 298.5351182 0.638039109 -0.648283238 0.140091243 1 8.744360145 5.819574946 389792 immediate early response 5 like IFFO1 134.9730603 100.4806409 169.4654796 1.686548555 0.754073853 0.219912684 1 1.193757914 2.100056805 25900 intermediate filament family orphan 1 "GO:0005515,GO:0005654,GO:0005882,GO:0006303,GO:0016363,GO:0035861,GO:1990166,GO:1990683" protein binding|nucleoplasm|intermediate filament|double-strand break repair via nonhomologous end joining|nuclear matrix|site of double-strand break|protein localization to site of double-strand break|DNA double-strand break attachment to nuclear envelope IFFO2 434.4931968 470.9395693 398.0468243 0.845218474 -0.242603794 0.569091083 1 3.862579403 3.405354516 126917 intermediate filament family orphan 2 GO:0005882 intermediate filament IFI16 1130.679254 1117.466521 1143.891988 1.023647658 0.033719222 0.924786982 1 10.65030808 11.37178388 3428 interferon gamma inducible protein 16 "GO:0000122,GO:0000978,GO:0001227,GO:0001819,GO:0002218,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006914,GO:0006954,GO:0008134,GO:0010506,GO:0016020,GO:0016607,GO:0030099,GO:0030224,GO:0032481,GO:0032731,GO:0035458,GO:0040029,GO:0042149,GO:0042771,GO:0043392,GO:0045071,GO:0045087,GO:0045824,GO:0045892,GO:0045944,GO:0051607,GO:0071479,GO:0072332,GO:0097202,GO:2000117" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|positive regulation of cytokine production|activation of innate immune response|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|autophagy|inflammatory response|transcription factor binding|regulation of autophagy|membrane|nuclear speck|myeloid cell differentiation|monocyte differentiation|positive regulation of type I interferon production|positive regulation of interleukin-1 beta production|cellular response to interferon-beta|regulation of gene expression, epigenetic|cellular response to glucose starvation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of DNA binding|negative regulation of viral genome replication|innate immune response|negative regulation of innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|defense response to virus|cellular response to ionizing radiation|intrinsic apoptotic signaling pathway by p53 class mediator|activation of cysteine-type endopeptidase activity|negative regulation of cysteine-type endopeptidase activity" hsa04621 NOD-like receptor signaling pathway IFI27 3492.750493 3636.587235 3348.913752 0.920894656 -0.118891963 0.709048494 1 246.8905018 237.1538967 3429 interferon alpha inducible protein 27 "GO:0000122,GO:0001102,GO:0003674,GO:0005515,GO:0005521,GO:0005635,GO:0005637,GO:0005739,GO:0005741,GO:0005789,GO:0006915,GO:0016021,GO:0016032,GO:0031966,GO:0042802,GO:0043161,GO:0044827,GO:0045087,GO:0046825,GO:0051607,GO:0060337,GO:0070936,GO:0097190,GO:0097191" negative regulation of transcription by RNA polymerase II|RNA polymerase II activating transcription factor binding|molecular_function|protein binding|lamin binding|nuclear envelope|nuclear inner membrane|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum membrane|apoptotic process|integral component of membrane|viral process|mitochondrial membrane|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|modulation by host of viral genome replication|innate immune response|regulation of protein export from nucleus|defense response to virus|type I interferon signaling pathway|protein K48-linked ubiquitination|apoptotic signaling pathway|extrinsic apoptotic signaling pathway IFI27L1 331.2052204 280.1278473 382.2825936 1.364671872 0.448554104 0.328634267 1 3.768256901 5.363949407 122509 interferon alpha inducible protein 27 like 1 "GO:0005515,GO:0005739,GO:0006915,GO:0016021,GO:0097190" protein binding|mitochondrion|apoptotic process|integral component of membrane|apoptotic signaling pathway IFI27L2 554.0016635 558.2257826 549.7775444 0.984865912 -0.022000778 0.9608679 1 62.68773079 64.39847527 83982 interferon alpha inducible protein 27 like 2 "GO:0005739,GO:0006915,GO:0016021,GO:0031966,GO:0097190" mitochondrion|apoptotic process|integral component of membrane|mitochondrial membrane|apoptotic signaling pathway IFI30 500.1387277 580.5548139 419.7226414 0.722968153 -0.467995998 0.252232025 1 29.76017535 22.44246634 10437 IFI30 lysosomal thiol reductase "GO:0005515,GO:0005576,GO:0005764,GO:0005829,GO:0016491,GO:0016667,GO:0019886,GO:0030054,GO:0042590,GO:0043202,GO:0043231,GO:0048147,GO:0050821,GO:0055114,GO:0060333" "protein binding|extracellular region|lysosome|cytosol|oxidoreductase activity|oxidoreductase activity, acting on a sulfur group of donors|antigen processing and presentation of exogenous peptide antigen via MHC class II|cell junction|antigen processing and presentation of exogenous peptide antigen via MHC class I|lysosomal lumen|intracellular membrane-bounded organelle|negative regulation of fibroblast proliferation|protein stabilization|oxidation-reduction process|interferon-gamma-mediated signaling pathway" hsa04612 Antigen processing and presentation IFI35 351.0265534 321.741042 380.3120648 1.182043989 0.241283726 0.595006108 1 11.63101266 14.34059257 3430 interferon induced protein 35 "GO:0002281,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0008285,GO:0016020,GO:0034145,GO:0042802,GO:0045089,GO:0050729,GO:0060337,GO:1901223,GO:1901224" macrophage activation involved in immune response|protein binding|extracellular space|nucleus|cytoplasm|cytosol|negative regulation of cell population proliferation|membrane|positive regulation of toll-like receptor 4 signaling pathway|identical protein binding|positive regulation of innate immune response|positive regulation of inflammatory response|type I interferon signaling pathway|negative regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling IFI44 873.4928285 1148.930156 598.0555008 0.520532512 -0.941939818 0.00951135 0.410563194 22.45822433 12.19380389 10561 interferon induced protein 44 "GO:0005515,GO:0005737,GO:0006955,GO:0009615,GO:0009617" protein binding|cytoplasm|immune response|response to virus|response to bacterium IFI44L 86.4130341 81.19647747 91.62959074 1.128492191 0.174396435 0.819851492 1 0.697830501 0.821418416 10964 interferon induced protein 44 like "GO:0003674,GO:0005525,GO:0005575,GO:0005737,GO:0006955,GO:0051607" molecular_function|GTP binding|cellular_component|cytoplasm|immune response|defense response to virus IFI6 164.6591615 176.6023385 152.7159846 0.864744974 -0.209653372 0.722010164 1 10.66065009 9.615849672 2537 interferon alpha inducible protein 6 "GO:0001836,GO:0005515,GO:0005739,GO:0005743,GO:0005886,GO:0006915,GO:0006955,GO:0016021,GO:0031966,GO:0042058,GO:0043066,GO:0043154,GO:0045087,GO:0051607,GO:0051902,GO:0060337,GO:0072593,GO:0097190,GO:0097193,GO:0098586,GO:2001240" release of cytochrome c from mitochondria|protein binding|mitochondrion|mitochondrial inner membrane|plasma membrane|apoptotic process|immune response|integral component of membrane|mitochondrial membrane|regulation of epidermal growth factor receptor signaling pathway|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|innate immune response|defense response to virus|negative regulation of mitochondrial depolarization|type I interferon signaling pathway|reactive oxygen species metabolic process|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|cellular response to virus|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IFIH1 150.8803055 177.6172945 124.1433165 0.698937099 -0.51676547 0.383731108 1 2.5120607 1.831403973 64135 interferon induced with helicase C domain 1 "GO:0003677,GO:0003724,GO:0003725,GO:0003727,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0008270,GO:0009597,GO:0009615,GO:0016032,GO:0016579,GO:0016925,GO:0032480,GO:0032727,GO:0032728,GO:0032755,GO:0032760,GO:0034344,GO:0039528,GO:0039530,GO:0042802,GO:0043021,GO:0045087,GO:0051607,GO:0060760,GO:0071360" DNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|zinc ion binding|detection of virus|response to virus|viral process|protein deubiquitination|protein sumoylation|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|regulation of type III interferon production|cytoplasmic pattern recognition receptor signaling pathway in response to virus|MDA-5 signaling pathway|identical protein binding|ribonucleoprotein complex binding|innate immune response|defense response to virus|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA "hsa04622,hsa05161,hsa05162,hsa05164,hsa05168,hsa05171" RIG-I-like receptor signaling pathway|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19 IFIT1 420.178409 637.3923481 202.9644698 0.318429411 -1.650954503 0.000162683 0.023967512 7.153040959 2.375854359 3434 interferon induced protein with tetratricopeptide repeats 1 "GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0009615,GO:0016032,GO:0019060,GO:0032091,GO:0043657,GO:0045070,GO:0045071,GO:0050688,GO:0051097,GO:0051607,GO:0060337,GO:0071357,GO:0071360" RNA binding|protein binding|cytoplasm|cytosol|response to virus|viral process|intracellular transport of viral protein in host cell|negative regulation of protein binding|host cell|positive regulation of viral genome replication|negative regulation of viral genome replication|regulation of defense response to virus|negative regulation of helicase activity|defense response to virus|type I interferon signaling pathway|cellular response to type I interferon|cellular response to exogenous dsRNA hsa05160 Hepatitis C IFIT2 479.8853834 711.4841338 248.286633 0.348970021 -1.518824992 0.000308066 0.040539044 10.62014778 3.865757517 3433 interferon induced protein with tetratricopeptide repeats 2 "GO:0003723,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0008637,GO:0009615,GO:0032091,GO:0035457,GO:0043065,GO:0051607,GO:0060337" RNA binding|protein binding|cytoplasm|endoplasmic reticulum|cytosol|apoptotic mitochondrial changes|response to virus|negative regulation of protein binding|cellular response to interferon-alpha|positive regulation of apoptotic process|defense response to virus|type I interferon signaling pathway IFIT3 493.6399911 641.452172 345.8278102 0.539132651 -0.891287809 0.030346577 0.779010436 12.44247017 6.997101479 3437 interferon induced protein with tetratricopeptide repeats 3 "GO:0003674,GO:0003723,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0008285,GO:0009615,GO:0035457,GO:0042802,GO:0043066,GO:0051607,GO:0060337" molecular_function|RNA binding|protein binding|cytoplasm|mitochondrion|cytosol|negative regulation of cell population proliferation|response to virus|cellular response to interferon-alpha|identical protein binding|negative regulation of apoptotic process|defense response to virus|type I interferon signaling pathway IFIT5 869.2414934 925.6398432 812.8431437 0.878141914 -0.187473986 0.605315531 1 11.63573904 10.65797284 24138 interferon induced protein with tetratricopeptide repeats 5 "GO:0000049,GO:0000339,GO:0003690,GO:0003723,GO:0003727,GO:0005515,GO:0005829,GO:0005886,GO:0008266,GO:0008385,GO:0015629,GO:0032587,GO:0043123,GO:0045071,GO:0045087,GO:0045177,GO:0051607" tRNA binding|RNA cap binding|double-stranded DNA binding|RNA binding|single-stranded RNA binding|protein binding|cytosol|plasma membrane|poly(U) RNA binding|IkappaB kinase complex|actin cytoskeleton|ruffle membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|innate immune response|apical part of cell|defense response to virus IFITM1 91.93318722 121.7947162 62.07165824 0.509641635 -0.972444953 0.164110179 1 9.234240584 4.908875469 8519 interferon induced transmembrane protein 1 "GO:0001503,GO:0005515,GO:0005886,GO:0007166,GO:0008285,GO:0009615,GO:0016020,GO:0016021,GO:0030336,GO:0032991,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0045669,GO:0046597,GO:0050776,GO:0051607,GO:0060337" ossification|protein binding|plasma membrane|cell surface receptor signaling pathway|negative regulation of cell population proliferation|response to virus|membrane|integral component of membrane|negative regulation of cell migration|protein-containing complex|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|positive regulation of osteoblast differentiation|negative regulation of viral entry into host cell|regulation of immune response|defense response to virus|type I interferon signaling pathway hsa04662 B cell receptor signaling pathway IFITM10 9.060374836 13.19442759 4.926322083 0.373363835 -1.421345905 0.34429886 1 0.179927628 0.070072245 402778 interferon induced transmembrane protein 10 "GO:0005886,GO:0016021" plasma membrane|integral component of membrane IFITM2 372.6375442 384.668312 360.6067765 0.937448615 -0.093188481 0.838478493 1 19.36589759 18.93655757 10581 interferon induced transmembrane protein 2 "GO:0005886,GO:0006955,GO:0009615,GO:0016021,GO:0032991,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0046597,GO:0051607,GO:0060337" plasma membrane|immune response|response to virus|integral component of membrane|protein-containing complex|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|negative regulation of viral entry into host cell|defense response to virus|type I interferon signaling pathway IFITM3 5731.132446 5344.758129 6117.506762 1.144580655 0.194819129 0.547091551 1 443.032969 528.930216 10410 interferon induced transmembrane protein 3 "GO:0005515,GO:0005765,GO:0005886,GO:0006955,GO:0009615,GO:0016021,GO:0031902,GO:0032897,GO:0032991,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0046597,GO:0048471,GO:0051607,GO:0060337" protein binding|lysosomal membrane|plasma membrane|immune response|response to virus|integral component of membrane|late endosome membrane|negative regulation of viral transcription|protein-containing complex|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|negative regulation of viral entry into host cell|perinuclear region of cytoplasm|defense response to virus|type I interferon signaling pathway IFNAR1 1513.57696 1631.034241 1396.119678 0.855972023 -0.224364452 0.498508686 1 13.02319571 11.62767988 3454 interferon alpha and beta receptor subunit 1 "GO:0004896,GO:0004905,GO:0005515,GO:0005764,GO:0005770,GO:0005886,GO:0005887,GO:0007259,GO:0009615,GO:0016021,GO:0019221,GO:0019962,GO:0032496,GO:0035457,GO:0060337" cytokine receptor activity|type I interferon receptor activity|protein binding|lysosome|late endosome|plasma membrane|integral component of plasma membrane|receptor signaling pathway via JAK-STAT|response to virus|integral component of membrane|cytokine-mediated signaling pathway|type I interferon binding|response to lipopolysaccharide|cellular response to interferon-alpha|type I interferon signaling pathway "hsa04060,hsa04151,hsa04217,hsa04380,hsa04620,hsa04621,hsa04630,hsa04650,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer IFNAR2 648.777321 604.9137572 692.6408848 1.14502419 0.195378077 0.612723443 1 7.114897304 8.497657591 3455 interferon alpha and beta receptor subunit 2 "GO:0004896,GO:0004905,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007166,GO:0007259,GO:0009615,GO:0016021,GO:0019221,GO:0019901,GO:0035455,GO:0035456,GO:0051607,GO:0060337,GO:0060338" cytokine receptor activity|type I interferon receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|receptor signaling pathway via JAK-STAT|response to virus|integral component of membrane|cytokine-mediated signaling pathway|protein kinase binding|response to interferon-alpha|response to interferon-beta|defense response to virus|type I interferon signaling pathway|regulation of type I interferon-mediated signaling pathway "hsa04060,hsa04151,hsa04217,hsa04380,hsa04620,hsa04621,hsa04630,hsa04650,hsa05160,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer IFNE 15.94237998 12.17947162 19.70528833 1.617909951 0.694131313 0.584370786 1 0.41820154 0.705758152 338376 interferon epsilon "GO:0002250,GO:0002286,GO:0002323,GO:0005125,GO:0005132,GO:0005615,GO:0006959,GO:0019221,GO:0030183,GO:0033141,GO:0042100,GO:0042742,GO:0043330,GO:0051607" adaptive immune response|T cell activation involved in immune response|natural killer cell activation involved in immune response|cytokine activity|type I interferon receptor binding|extracellular space|humoral immune response|cytokine-mediated signaling pathway|B cell differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|B cell proliferation|defense response to bacterium|response to exogenous dsRNA|defense response to virus "hsa04060,hsa04622,hsa04630" Cytokine-cytokine receptor interaction|RIG-I-like receptor signaling pathway|JAK-STAT signaling pathway IFNGR1 533.890096 597.8090654 469.9711267 0.786155905 -0.347112649 0.388489421 1 11.16817419 9.15812969 3459 interferon gamma receptor 1 "GO:0001774,GO:0004896,GO:0004906,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0009615,GO:0010628,GO:0016021,GO:0019221,GO:0019955,GO:0032760,GO:0048143,GO:0060333,GO:0060334,GO:1900222,GO:1902004" microglial cell activation|cytokine receptor activity|interferon-gamma receptor activity|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|response to virus|positive regulation of gene expression|integral component of membrane|cytokine-mediated signaling pathway|cytokine binding|positive regulation of tumor necrosis factor production|astrocyte activation|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|negative regulation of amyloid-beta clearance|positive regulation of amyloid-beta formation "hsa04060,hsa04066,hsa04217,hsa04380,hsa04630,hsa04650,hsa04658,hsa04659,hsa05140,hsa05142,hsa05145,hsa05152,hsa05164,hsa05167,hsa05168,hsa05200,hsa05235,hsa05321" Cytokine-cytokine receptor interaction|HIF-1 signaling pathway|Necroptosis|Osteoclast differentiation|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Pathways in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease IFNGR2 2332.486583 2113.138326 2551.834839 1.207604257 0.272147748 0.394711405 1 46.79624028 58.94561828 3460 interferon gamma receptor 2 "GO:0000139,GO:0004896,GO:0004906,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0007166,GO:0009615,GO:0016021,GO:0019221,GO:0030659,GO:0060333,GO:0060334" Golgi membrane|cytokine receptor activity|interferon-gamma receptor activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|response to virus|integral component of membrane|cytokine-mediated signaling pathway|cytoplasmic vesicle membrane|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway "hsa04060,hsa04066,hsa04217,hsa04380,hsa04630,hsa04650,hsa04658,hsa04659,hsa05140,hsa05142,hsa05145,hsa05152,hsa05164,hsa05168,hsa05200,hsa05235,hsa05321" Cytokine-cytokine receptor interaction|HIF-1 signaling pathway|Necroptosis|Osteoclast differentiation|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Influenza A|Herpes simplex virus 1 infection|Pathways in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease IFNLR1 170.5789128 76.12169763 265.0361281 3.481742214 1.799809391 0.002039236 0.14395732 0.757425431 2.750758259 163702 interferon lambda receptor 1 "GO:0002385,GO:0004896,GO:0005515,GO:0005886,GO:0008285,GO:0016021,GO:0019221,GO:0032002,GO:0034342,GO:0050691,GO:0051607" mucosal immune response|cytokine receptor activity|protein binding|plasma membrane|negative regulation of cell population proliferation|integral component of membrane|cytokine-mediated signaling pathway|interleukin-28 receptor complex|response to type III interferon|regulation of defense response to virus by host|defense response to virus "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway IFRD1 877.3814301 875.9070007 878.8558596 1.003366635 0.004848869 0.992876355 1 11.14053229 11.65954295 3475 interferon related developmental regulator 1 "GO:0005634,GO:0006357,GO:0007275,GO:0007518" nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|myoblast fate determination IFRD2 1285.713902 1242.306105 1329.121698 1.06988261 0.097452509 0.775074435 1 32.38210069 36.13741448 7866 interferon related developmental regulator 2 "GO:0003674,GO:0005515,GO:0005634" molecular_function|protein binding|nucleus IFT122 353.1752315 333.9205136 372.4299495 1.115325158 0.157464369 0.730436895 1 2.686986974 3.125956924 55764 intraflagellar transport 122 "GO:0001843,GO:0005515,GO:0005737,GO:0005929,GO:0010172,GO:0016020,GO:0030991,GO:0032391,GO:0035050,GO:0035721,GO:0035735,GO:0036064,GO:0042073,GO:0045879,GO:0048593,GO:0060173,GO:0060271,GO:0061512,GO:0097542,GO:0097730,GO:1905515" neural tube closure|protein binding|cytoplasm|cilium|embryonic body morphogenesis|membrane|intraciliary transport particle A|photoreceptor connecting cilium|embryonic heart tube development|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|negative regulation of smoothened signaling pathway|camera-type eye morphogenesis|limb development|cilium assembly|protein localization to cilium|ciliary tip|non-motile cilium|non-motile cilium assembly IFT140 394.2782266 449.625494 338.9309593 0.753807255 -0.407732415 0.349664778 1 1.755875171 1.380606393 9742 intraflagellar transport 140 "GO:0001750,GO:0003674,GO:0005515,GO:0005813,GO:0005814,GO:0005929,GO:0005930,GO:0007368,GO:0007507,GO:0008589,GO:0021532,GO:0030991,GO:0031076,GO:0032391,GO:0035721,GO:0035735,GO:0035845,GO:0036064,GO:0042073,GO:0042733,GO:0048701,GO:0060271,GO:0061512,GO:0097542,GO:1902017,GO:1905515,GO:1990403" photoreceptor outer segment|molecular_function|protein binding|centrosome|centriole|cilium|axoneme|determination of left/right symmetry|heart development|regulation of smoothened signaling pathway|neural tube patterning|intraciliary transport particle A|embryonic camera-type eye development|photoreceptor connecting cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|photoreceptor cell outer segment organization|ciliary basal body|intraciliary transport|embryonic digit morphogenesis|embryonic cranial skeleton morphogenesis|cilium assembly|protein localization to cilium|ciliary tip|regulation of cilium assembly|non-motile cilium assembly|embryonic brain development IFT172 436.2558848 456.7301858 415.7815838 0.910343999 -0.135516284 0.752692173 1 3.048869469 2.895078171 26160 intraflagellar transport 172 "GO:0001843,GO:0001947,GO:0005929,GO:0005930,GO:0007219,GO:0007224,GO:0007420,GO:0008544,GO:0009953,GO:0016485,GO:0021522,GO:0030992,GO:0031122,GO:0035735,GO:0036064,GO:0042073,GO:0045879,GO:0045880,GO:0048596,GO:0050680,GO:0060021,GO:0060173,GO:0060271,GO:0060348,GO:0061525,GO:0070986,GO:0097225,GO:0097228,GO:0097542,GO:0097598,GO:1903561,GO:1905515" neural tube closure|heart looping|cilium|axoneme|Notch signaling pathway|smoothened signaling pathway|brain development|epidermis development|dorsal/ventral pattern formation|protein processing|spinal cord motor neuron differentiation|intraciliary transport particle B|cytoplasmic microtubule organization|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|embryonic camera-type eye morphogenesis|negative regulation of epithelial cell proliferation|roof of mouth development|limb development|cilium assembly|bone development|hindgut development|left/right axis specification|sperm midpiece|sperm principal piece|ciliary tip|sperm cytoplasmic droplet|extracellular vesicle|non-motile cilium assembly IFT20 356.3240199 347.1149412 365.5330985 1.053060687 0.07458858 0.873741292 1 14.46925697 15.8933541 90410 intraflagellar transport 20 "GO:0000139,GO:0001736,GO:0001750,GO:0001822,GO:0002046,GO:0005515,GO:0005794,GO:0005801,GO:0005813,GO:0005814,GO:0005902,GO:0005929,GO:0007224,GO:0007283,GO:0008542,GO:0030992,GO:0031267,GO:0031514,GO:0032391,GO:0032420,GO:0034067,GO:0035735,GO:0035845,GO:0036372,GO:0042073,GO:0044292,GO:0045198,GO:0051642,GO:0055007,GO:0060122,GO:0060271,GO:0060828,GO:0061351,GO:0061512,GO:0072659,GO:0090102,GO:0097542,GO:0097546,GO:1902017,GO:1902636,GO:2000583,GO:2000785" Golgi membrane|establishment of planar polarity|photoreceptor outer segment|kidney development|opsin binding|protein binding|Golgi apparatus|cis-Golgi network|centrosome|centriole|microvillus|cilium|smoothened signaling pathway|spermatogenesis|visual learning|intraciliary transport particle B|small GTPase binding|motile cilium|photoreceptor connecting cilium|stereocilium|protein localization to Golgi apparatus|intraciliary transport involved in cilium assembly|photoreceptor cell outer segment organization|opsin transport|intraciliary transport|dendrite terminus|establishment of epithelial cell apical/basal polarity|centrosome localization|cardiac muscle cell differentiation|inner ear receptor cell stereocilium organization|cilium assembly|regulation of canonical Wnt signaling pathway|neural precursor cell proliferation|protein localization to cilium|protein localization to plasma membrane|cochlea development|ciliary tip|ciliary base|regulation of cilium assembly|kinociliary basal body|regulation of platelet-derived growth factor receptor-alpha signaling pathway|regulation of autophagosome assembly IFT22 740.7820155 765.2768002 716.2872308 0.93598451 -0.095443441 0.800963277 1 7.806358548 7.621370698 64792 intraflagellar transport 22 "GO:0003924,GO:0005525,GO:0005813,GO:0005929,GO:0006886,GO:0012505,GO:0030992,GO:0035735,GO:0097542" GTPase activity|GTP binding|centrosome|cilium|intracellular protein transport|endomembrane system|intraciliary transport particle B|intraciliary transport involved in cilium assembly|ciliary tip IFT27 101.5807121 74.09178569 129.0696386 1.742023591 0.800764161 0.236191024 1 1.49859727 2.723045505 11020 intraflagellar transport 27 "GO:0000139,GO:0001822,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0005813,GO:0005929,GO:0006886,GO:0007224,GO:0007283,GO:0030992,GO:0031514,GO:0035735,GO:0036126,GO:0042073,GO:0060122,GO:0090102,GO:0097225,GO:0097228,GO:0097542" Golgi membrane|kidney development|GTPase activity|protein binding|GTP binding|cytoplasm|Golgi apparatus|centrosome|cilium|intracellular protein transport|smoothened signaling pathway|spermatogenesis|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|sperm flagellum|intraciliary transport|inner ear receptor cell stereocilium organization|cochlea development|sperm midpiece|sperm principal piece|ciliary tip IFT43 394.9841429 396.8477836 393.1205022 0.990607781 -0.013614142 0.981558778 1 13.32820971 13.77176115 112752 intraflagellar transport 43 "GO:0005515,GO:0005737,GO:0005929,GO:0015630,GO:0030991,GO:0034451,GO:0035721,GO:0035735,GO:0060271,GO:0097542" protein binding|cytoplasm|cilium|microtubule cytoskeleton|intraciliary transport particle A|centriolar satellite|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|cilium assembly|ciliary tip IFT46 471.450015 538.9416192 403.9584108 0.749540203 -0.415922233 0.316339894 1 4.889036672 3.822382611 56912 intraflagellar transport 46 "GO:0003674,GO:0005737,GO:0005813,GO:0005929,GO:0008022,GO:0008150,GO:0030992,GO:0031514,GO:0035735,GO:0036064,GO:0042073,GO:0050821,GO:0060271,GO:0097542" molecular_function|cytoplasm|centrosome|cilium|protein C-terminus binding|biological_process|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|protein stabilization|cilium assembly|ciliary tip IFT52 1060.451576 997.7017169 1123.201435 1.125788816 0.170936221 0.625366062 1 26.07330871 30.61744924 51098 intraflagellar transport 52 "GO:0001841,GO:0001947,GO:0005813,GO:0005814,GO:0005929,GO:0007224,GO:0008022,GO:0009953,GO:0030992,GO:0031514,GO:0032391,GO:0035720,GO:0035735,GO:0036064,GO:0042073,GO:0042733,GO:0044292,GO:0050680,GO:0060271,GO:0070613,GO:0097542,GO:0097546,GO:1905515" neural tube formation|heart looping|centrosome|centriole|cilium|smoothened signaling pathway|protein C-terminus binding|dorsal/ventral pattern formation|intraciliary transport particle B|motile cilium|photoreceptor connecting cilium|intraciliary anterograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|embryonic digit morphogenesis|dendrite terminus|negative regulation of epithelial cell proliferation|cilium assembly|regulation of protein processing|ciliary tip|ciliary base|non-motile cilium assembly IFT57 615.3525597 609.988537 620.7165824 1.01758729 0.025152556 0.952872781 1 10.1059102 10.72662353 55081 intraflagellar transport 57 "GO:0001843,GO:0001947,GO:0003677,GO:0005515,GO:0005794,GO:0005813,GO:0005929,GO:0005930,GO:0006915,GO:0006919,GO:0007224,GO:0030992,GO:0032391,GO:0035735,GO:0036064,GO:0042073,GO:0042981,GO:0044292,GO:0044458,GO:0050680,GO:0060972,GO:0097542,GO:1905515" neural tube closure|heart looping|DNA binding|protein binding|Golgi apparatus|centrosome|cilium|axoneme|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|smoothened signaling pathway|intraciliary transport particle B|photoreceptor connecting cilium|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|regulation of apoptotic process|dendrite terminus|motile cilium assembly|negative regulation of epithelial cell proliferation|left/right pattern formation|ciliary tip|non-motile cilium assembly "hsa05016,hsa05022" Huntington disease|Pathways of neurodegeneration - multiple diseases IFT74 413.1345841 425.2665507 401.0026175 0.942944177 -0.084755731 0.848610596 1 2.487095906 2.446213987 80173 intraflagellar transport 74 "GO:0003334,GO:0003682,GO:0005515,GO:0005634,GO:0005813,GO:0005929,GO:0007219,GO:0007368,GO:0007507,GO:0030992,GO:0031410,GO:0031514,GO:0033630,GO:0035735,GO:0045944,GO:0048487,GO:0050680,GO:0060271,GO:0097542,GO:1905515" keratinocyte development|chromatin binding|protein binding|nucleus|centrosome|cilium|Notch signaling pathway|determination of left/right symmetry|heart development|intraciliary transport particle B|cytoplasmic vesicle|motile cilium|positive regulation of cell adhesion mediated by integrin|intraciliary transport involved in cilium assembly|positive regulation of transcription by RNA polymerase II|beta-tubulin binding|negative regulation of epithelial cell proliferation|cilium assembly|ciliary tip|non-motile cilium assembly IFT80 516.9206359 549.0911789 484.7500929 0.882822583 -0.17980456 0.659767999 1 6.206099338 5.714892779 57560 intraflagellar transport 80 "GO:0001649,GO:0001958,GO:0003418,GO:0005737,GO:0005813,GO:0005929,GO:0007224,GO:0030992,GO:0033687,GO:0035630,GO:0035735,GO:0036064,GO:0050680,GO:0060173,GO:0060271,GO:0061975,GO:0097500,GO:0097542,GO:0097731,GO:1905515,GO:2000051" osteoblast differentiation|endochondral ossification|growth plate cartilage chondrocyte differentiation|cytoplasm|centrosome|cilium|smoothened signaling pathway|intraciliary transport particle B|osteoblast proliferation|bone mineralization involved in bone maturation|intraciliary transport involved in cilium assembly|ciliary basal body|negative regulation of epithelial cell proliferation|limb development|cilium assembly|articular cartilage development|receptor localization to non-motile cilium|ciliary tip|9+0 non-motile cilium|non-motile cilium assembly|negative regulation of non-canonical Wnt signaling pathway IFT81 316.3196122 306.5167024 326.1225219 1.063963299 0.089448386 0.853569125 1 3.663910704 4.066188031 28981 intraflagellar transport 81 "GO:0005515,GO:0005813,GO:0005929,GO:0007283,GO:0008589,GO:0015631,GO:0030992,GO:0031514,GO:0035735,GO:0036064,GO:0042073,GO:0060271,GO:0097542" protein binding|centrosome|cilium|spermatogenesis|regulation of smoothened signaling pathway|tubulin binding|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|cilium assembly|ciliary tip IFT88 184.9582809 217.2005772 152.7159846 0.703110399 -0.508176862 0.359217093 1 1.936356803 1.420119323 8100 intraflagellar transport 88 "GO:0001822,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005929,GO:0019894,GO:0030992,GO:0031514,GO:0035735,GO:0036064,GO:0036126,GO:0042073,GO:0060122,GO:0060271,GO:0097542,GO:0097546,GO:0097730,GO:1902017,GO:1905515,GO:2000785" kidney development|protein binding|cytoplasm|centrosome|centriole|cilium|kinesin binding|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|ciliary basal body|sperm flagellum|intraciliary transport|inner ear receptor cell stereocilium organization|cilium assembly|ciliary tip|ciliary base|non-motile cilium|regulation of cilium assembly|non-motile cilium assembly|regulation of autophagosome assembly IFTAP 179.8538095 205.0211056 154.6865134 0.75449068 -0.406425015 0.468801589 1 7.860405547 6.18606904 119710 intraflagellar transport associated protein "GO:0005515,GO:0005829,GO:0007283,GO:0007340,GO:0097731,GO:0120160" protein binding|cytosol|spermatogenesis|acrosome reaction|9+0 non-motile cilium|intraciliary transport particle A binding IGBP1 1388.285321 1249.410797 1527.159846 1.222304025 0.289603172 0.387391767 1 33.94755859 43.28164096 3476 immunoglobulin binding protein 1 "GO:0000122,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0019888,GO:0032873,GO:0034612,GO:0035303,GO:0042113,GO:0043154,GO:0043666,GO:0051721,GO:0060632,GO:0070555" negative regulation of transcription by RNA polymerase II|protein binding|cytoplasm|cytosol|signal transduction|protein phosphatase regulator activity|negative regulation of stress-activated MAPK cascade|response to tumor necrosis factor|regulation of dephosphorylation|B cell activation|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of phosphoprotein phosphatase activity|protein phosphatase 2A binding|regulation of microtubule-based movement|response to interleukin-1 "hsa04136,hsa04140" Autophagy - other|Autophagy - animal IGDCC4 26.95843787 24.35894324 29.5579325 1.213432463 0.279093814 0.813932605 1 0.176393272 0.223261354 57722 immunoglobulin superfamily DCC subclass member 4 "GO:0005886,GO:0016021" plasma membrane|integral component of membrane IGF1R 1196.663517 1283.9193 1109.407733 0.864079022 -0.210764839 0.538640119 1 4.851599131 4.3727465 3480 insulin like growth factor 1 receptor "GO:0004713,GO:0004714,GO:0005009,GO:0005010,GO:0005158,GO:0005515,GO:0005520,GO:0005524,GO:0005886,GO:0005887,GO:0005899,GO:0006955,GO:0007165,GO:0007169,GO:0007275,GO:0008284,GO:0008286,GO:0014065,GO:0014068,GO:0016020,GO:0016032,GO:0030335,GO:0030424,GO:0031994,GO:0033674,GO:0035867,GO:0038083,GO:0042593,GO:0042802,GO:0043066,GO:0043231,GO:0043235,GO:0043243,GO:0043410,GO:0043548,GO:0043559,GO:0043560,GO:0045056,GO:0046328,GO:0046777,GO:0048009,GO:0048015,GO:0051389,GO:0051897,GO:0071333,GO:0097062,GO:0097242,GO:0120162,GO:0140318,GO:1902911,GO:1904646" protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|insulin-activated receptor activity|insulin-like growth factor-activated receptor activity|insulin receptor binding|protein binding|insulin-like growth factor binding|ATP binding|plasma membrane|integral component of plasma membrane|insulin receptor complex|immune response|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|positive regulation of cell population proliferation|insulin receptor signaling pathway|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|viral process|positive regulation of cell migration|axon|insulin-like growth factor I binding|positive regulation of kinase activity|alphav-beta3 integrin-IGF-1-IGF1R complex|peptidyl-tyrosine autophosphorylation|glucose homeostasis|identical protein binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|receptor complex|positive regulation of protein-containing complex disassembly|positive regulation of MAPK cascade|phosphatidylinositol 3-kinase binding|insulin binding|insulin receptor substrate binding|transcytosis|regulation of JNK cascade|protein autophosphorylation|insulin-like growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|inactivation of MAPKK activity|positive regulation of protein kinase B signaling|cellular response to glucose stimulus|dendritic spine maintenance|amyloid-beta clearance|positive regulation of cold-induced thermogenesis|protein transporter activity|protein kinase complex|cellular response to amyloid-beta "hsa01521,hsa01522,hsa04010,hsa04014,hsa04015,hsa04066,hsa04068,hsa04114,hsa04140,hsa04144,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04510,hsa04520,hsa04550,hsa04730,hsa04913,hsa04914,hsa05200,hsa05202,hsa05205,hsa05214,hsa05215,hsa05218,hsa05224,hsa05225" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Oocyte meiosis|Autophagy - animal|Endocytosis|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Focal adhesion|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Long-term depression|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|Glioma|Prostate cancer|Melanoma|Breast cancer|Hepatocellular carcinoma IGF2 70.3667337 61.91231407 78.82115332 1.27310947 0.348356476 0.657136922 1 0.474234769 0.629759996 3481 insulin like growth factor 2 "GO:0000122,GO:0001501,GO:0001649,GO:0001701,GO:0001892,GO:0001934,GO:0002576,GO:0005158,GO:0005159,GO:0005178,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0006006,GO:0006349,GO:0006355,GO:0007275,GO:0008083,GO:0008284,GO:0008286,GO:0009887,GO:0031017,GO:0031056,GO:0031093,GO:0038028,GO:0040018,GO:0042104,GO:0043085,GO:0043410,GO:0043539,GO:0044267,GO:0045725,GO:0045840,GO:0045944,GO:0046622,GO:0046628,GO:0048018,GO:0048633,GO:0050731,GO:0051146,GO:0051147,GO:0051148,GO:0051781,GO:0051897,GO:0060669,GO:0071902,GO:1905564,GO:2000467" "negative regulation of transcription by RNA polymerase II|skeletal system development|osteoblast differentiation|in utero embryonic development|embryonic placenta development|positive regulation of protein phosphorylation|platelet degranulation|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding|hormone activity|protein binding|extracellular region|extracellular space|glucose metabolic process|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-templated|multicellular organism development|growth factor activity|positive regulation of cell population proliferation|insulin receptor signaling pathway|animal organ morphogenesis|exocrine pancreas development|regulation of histone modification|platelet alpha granule lumen|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|positive regulation of multicellular organism growth|positive regulation of activated T cell proliferation|positive regulation of catalytic activity|positive regulation of MAPK cascade|protein serine/threonine kinase activator activity|cellular protein metabolic process|positive regulation of glycogen biosynthetic process|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|positive regulation of organ growth|positive regulation of insulin receptor signaling pathway|receptor ligand activity|positive regulation of skeletal muscle tissue growth|positive regulation of peptidyl-tyrosine phosphorylation|striated muscle cell differentiation|regulation of muscle cell differentiation|negative regulation of muscle cell differentiation|positive regulation of cell division|positive regulation of protein kinase B signaling|embryonic placenta morphogenesis|positive regulation of protein serine/threonine kinase activity|positive regulation of vascular endothelial cell proliferation|positive regulation of glycogen (starch) synthase activity" "hsa04010,hsa04014,hsa04151,hsa05200,hsa05205,hsa05225" MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Pathways in cancer|Proteoglycans in cancer|Hepatocellular carcinoma IGF2BP1 2178.944678 1989.313698 2368.575657 1.19064965 0.25174896 0.432482489 1 11.08501716 13.76690412 10642 insulin like growth factor 2 mRNA binding protein 1 "GO:0001817,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007399,GO:0010468,GO:0010494,GO:0010610,GO:0017148,GO:0022013,GO:0030027,GO:0030175,GO:0030426,GO:0043197,GO:0043488,GO:0045182,GO:0048027,GO:0048471,GO:0051028,GO:0051252,GO:0070934,GO:0070937,GO:0097150,GO:1990904" regulation of cytokine production|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|nervous system development|regulation of gene expression|cytoplasmic stress granule|regulation of mRNA stability involved in response to stress|negative regulation of translation|pallium cell proliferation in forebrain|lamellipodium|filopodium|growth cone|dendritic spine|regulation of mRNA stability|translation regulator activity|mRNA 5'-UTR binding|perinuclear region of cytoplasm|mRNA transport|regulation of RNA metabolic process|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|neuronal stem cell population maintenance|ribonucleoprotein complex hsa05206 MicroRNAs in cancer IGF2BP2 1856.917114 1932.476164 1781.358065 0.921800796 -0.117473082 0.717978521 1 14.64070312 14.07715662 10644 insulin like growth factor 2 mRNA binding protein 2 "GO:0001817,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0007399,GO:0009653,GO:0010468,GO:0017148,GO:0043488,GO:0045182,GO:0048027,GO:0051028,GO:0051252" regulation of cytokine production|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|nervous system development|anatomical structure morphogenesis|regulation of gene expression|negative regulation of translation|regulation of mRNA stability|translation regulator activity|mRNA 5'-UTR binding|mRNA transport|regulation of RNA metabolic process IGF2BP3 955.0931096 934.7744469 975.4117724 1.043472867 0.061393088 0.865441745 1 10.77937797 11.73250616 10643 insulin like growth factor 2 mRNA binding protein 3 "GO:0001817,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006412,GO:0007399,GO:0009653,GO:0010468,GO:0017148,GO:0043488,GO:0045182,GO:0048027,GO:0051028,GO:0051252" regulation of cytokine production|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|translation|nervous system development|anatomical structure morphogenesis|regulation of gene expression|negative regulation of translation|regulation of mRNA stability|translation regulator activity|mRNA 5'-UTR binding|mRNA transport|regulation of RNA metabolic process IGF2R 8007.920421 9678.620114 6337.220727 0.6547649 -0.610951111 0.065386873 1 34.86152938 23.80936185 3482 insulin like growth factor 2 receptor "GO:0001889,GO:0001965,GO:0001972,GO:0005010,GO:0005515,GO:0005520,GO:0005537,GO:0005641,GO:0005768,GO:0005769,GO:0005770,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0005925,GO:0006898,GO:0007041,GO:0007165,GO:0007186,GO:0007283,GO:0009791,GO:0009986,GO:0010008,GO:0016020,GO:0019899,GO:0030118,GO:0030133,GO:0030139,GO:0030140,GO:0030665,GO:0030667,GO:0031100,GO:0031995,GO:0032526,GO:0032588,GO:0038023,GO:0042802,GO:0043065,GO:0043312,GO:0044794,GO:0048009,GO:0048471,GO:0051219,GO:0061024,GO:0070062,GO:1904772,GO:1905394" liver development|G-protein alpha-subunit binding|retinoic acid binding|insulin-like growth factor-activated receptor activity|protein binding|insulin-like growth factor binding|mannose binding|nuclear envelope lumen|endosome|early endosome|late endosome|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|focal adhesion|receptor-mediated endocytosis|lysosomal transport|signal transduction|G protein-coupled receptor signaling pathway|spermatogenesis|post-embryonic development|cell surface|endosome membrane|membrane|enzyme binding|clathrin coat|transport vesicle|endocytic vesicle|trans-Golgi network transport vesicle|clathrin-coated vesicle membrane|secretory granule membrane|animal organ regeneration|insulin-like growth factor II binding|response to retinoic acid|trans-Golgi network membrane|signaling receptor activity|identical protein binding|positive regulation of apoptotic process|neutrophil degranulation|positive regulation by host of viral process|insulin-like growth factor receptor signaling pathway|perinuclear region of cytoplasm|phosphoprotein binding|membrane organization|extracellular exosome|response to tetrachloromethane|retromer complex binding "hsa04142,hsa04144" Lysosome|Endocytosis IGFBP1 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.103136718 3484 insulin like growth factor binding protein 1 "GO:0005102,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0007165,GO:0007568,GO:0008286,GO:0030307,GO:0031994,GO:0031995,GO:0036499,GO:0042246,GO:0043567,GO:0043687,GO:0044267,GO:0090090" signaling receptor binding|protein binding|insulin-like growth factor binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|signal transduction|aging|insulin receptor signaling pathway|positive regulation of cell growth|insulin-like growth factor I binding|insulin-like growth factor II binding|PERK-mediated unfolded protein response|tissue regeneration|regulation of insulin-like growth factor receptor signaling pathway|post-translational protein modification|cellular protein metabolic process|negative regulation of canonical Wnt signaling pathway IGFBP2 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.086587208 0.058449931 3485 insulin like growth factor binding protein 2 "GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007565,GO:0007568,GO:0007584,GO:0009612,GO:0010226,GO:0016324,GO:0031410,GO:0031994,GO:0031995,GO:0032355,GO:0032526,GO:0032870,GO:0040008,GO:0042104,GO:0042493,GO:0043567,GO:0043627,GO:0044267,GO:0051384,GO:0070062,GO:0090090" signaling receptor binding|protein binding|extracellular region|extracellular space|signal transduction|female pregnancy|aging|response to nutrient|response to mechanical stimulus|response to lithium ion|apical plasma membrane|cytoplasmic vesicle|insulin-like growth factor I binding|insulin-like growth factor II binding|response to estradiol|response to retinoic acid|cellular response to hormone stimulus|regulation of growth|positive regulation of activated T cell proliferation|response to drug|regulation of insulin-like growth factor receptor signaling pathway|response to estrogen|cellular protein metabolic process|response to glucocorticoid|extracellular exosome|negative regulation of canonical Wnt signaling pathway IGFBP3 90.16777765 169.4976467 10.83790858 0.063941351 -3.967106955 1.34E-06 0.000548772 3.262811803 0.21761547 3486 insulin like growth factor binding protein 3 "GO:0001558,GO:0001649,GO:0001933,GO:0001968,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005634,GO:0005788,GO:0006468,GO:0006915,GO:0008160,GO:0008285,GO:0009968,GO:0010906,GO:0014912,GO:0016942,GO:0031994,GO:0031995,GO:0042567,GO:0042981,GO:0043065,GO:0043410,GO:0043567,GO:0043568,GO:0043666,GO:0043687,GO:0044267,GO:0044342,GO:0045663,GO:0046872,GO:0048662" regulation of cell growth|osteoblast differentiation|negative regulation of protein phosphorylation|fibronectin binding|protein binding|insulin-like growth factor binding|extracellular region|extracellular space|nucleus|endoplasmic reticulum lumen|protein phosphorylation|apoptotic process|protein tyrosine phosphatase activator activity|negative regulation of cell population proliferation|negative regulation of signal transduction|regulation of glucose metabolic process|negative regulation of smooth muscle cell migration|insulin-like growth factor binding protein complex|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor ternary complex|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of MAPK cascade|regulation of insulin-like growth factor receptor signaling pathway|positive regulation of insulin-like growth factor receptor signaling pathway|regulation of phosphoprotein phosphatase activity|post-translational protein modification|cellular protein metabolic process|type B pancreatic cell proliferation|positive regulation of myoblast differentiation|metal ion binding|negative regulation of smooth muscle cell proliferation "hsa04115,hsa04218,hsa04935,hsa05202" "p53 signaling pathway|Cellular senescence|Growth hormone synthesis, secretion and action|Transcriptional misregulation in cancer" IGFBP4 2951.572113 3079.376408 2823.767818 0.916993392 -0.125016757 0.694906763 1 70.72995541 67.65276017 3487 insulin like growth factor binding protein 4 "GO:0001558,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006954,GO:0007165,GO:0010906,GO:0031994,GO:0031995,GO:0043410,GO:0043567,GO:0043568,GO:0043687,GO:0044267,GO:0044342,GO:0090090" regulation of cell growth|signaling receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|inflammatory response|signal transduction|regulation of glucose metabolic process|insulin-like growth factor I binding|insulin-like growth factor II binding|positive regulation of MAPK cascade|regulation of insulin-like growth factor receptor signaling pathway|positive regulation of insulin-like growth factor receptor signaling pathway|post-translational protein modification|cellular protein metabolic process|type B pancreatic cell proliferation|negative regulation of canonical Wnt signaling pathway IGFBP5 10.47888836 9.134603715 11.823173 1.294327961 0.372203218 0.848192439 1 0.07415218 0.100111551 3488 insulin like growth factor binding protein 5 "GO:0001558,GO:0001649,GO:0001968,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0007165,GO:0007565,GO:0007568,GO:0014912,GO:0016942,GO:0017148,GO:0030336,GO:0031069,GO:0031994,GO:0031995,GO:0035556,GO:0042567,GO:0042593,GO:0043567,GO:0043568,GO:0043569,GO:0043687,GO:0044267,GO:0044342,GO:0045668,GO:0045926,GO:0048286,GO:0048662,GO:0051146,GO:0051897,GO:0060056,GO:0060416,GO:0071320,GO:0071407,GO:1901862,GO:1904205,GO:1904707,GO:1904754" regulation of cell growth|osteoblast differentiation|fibronectin binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|signal transduction|female pregnancy|aging|negative regulation of smooth muscle cell migration|insulin-like growth factor binding protein complex|negative regulation of translation|negative regulation of cell migration|hair follicle morphogenesis|insulin-like growth factor I binding|insulin-like growth factor II binding|intracellular signal transduction|insulin-like growth factor ternary complex|glucose homeostasis|regulation of insulin-like growth factor receptor signaling pathway|positive regulation of insulin-like growth factor receptor signaling pathway|negative regulation of insulin-like growth factor receptor signaling pathway|post-translational protein modification|cellular protein metabolic process|type B pancreatic cell proliferation|negative regulation of osteoblast differentiation|negative regulation of growth|lung alveolus development|negative regulation of smooth muscle cell proliferation|striated muscle cell differentiation|positive regulation of protein kinase B signaling|mammary gland involution|response to growth hormone|cellular response to cAMP|cellular response to organic cyclic compound|negative regulation of muscle tissue development|negative regulation of skeletal muscle hypertrophy|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration IGFBP6 2307.833445 2010.627773 2605.039117 1.295634703 0.373659015 0.242790864 1 107.5303101 145.321342 3489 insulin like growth factor binding protein 6 "GO:0000187,GO:0001968,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0007165,GO:0008285,GO:0016477,GO:0031994,GO:0031995,GO:0042568,GO:0042802,GO:0043567,GO:0044267,GO:0090090" activation of MAPK activity|fibronectin binding|signaling receptor binding|protein binding|extracellular region|extracellular space|Golgi apparatus|signal transduction|negative regulation of cell population proliferation|cell migration|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor binary complex|identical protein binding|regulation of insulin-like growth factor receptor signaling pathway|cellular protein metabolic process|negative regulation of canonical Wnt signaling pathway IGFBP7 3034.481544 2921.043277 3147.919811 1.077669693 0.107915058 0.735023624 1 92.81087651 104.3279018 3490 insulin like growth factor binding protein 7 "GO:0001558,GO:0005201,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005788,GO:0007155,GO:0007566,GO:0008285,GO:0009408,GO:0009966,GO:0032526,GO:0032870,GO:0043687,GO:0044267,GO:0050810,GO:0051414,GO:0062023,GO:0070062" regulation of cell growth|extracellular matrix structural constituent|protein binding|insulin-like growth factor binding|extracellular region|extracellular space|endoplasmic reticulum lumen|cell adhesion|embryo implantation|negative regulation of cell population proliferation|response to heat|regulation of signal transduction|response to retinoic acid|cellular response to hormone stimulus|post-translational protein modification|cellular protein metabolic process|regulation of steroid biosynthetic process|response to cortisol|collagen-containing extracellular matrix|extracellular exosome IGFLR1 44.93072978 40.59823873 49.26322083 1.213432463 0.279093814 0.768825771 1 1.542503803 1.952350477 79713 IGF like family receptor 1 "GO:0005515,GO:0005886,GO:0016021" protein binding|plasma membrane|integral component of membrane IGFN1 5082.778733 7059.01876 3106.538705 0.440080812 -1.184159626 0.000273924 0.036760011 29.75319553 13.65783869 91156 immunoglobulin like and fibronectin type III domain containing 1 "GO:0005515,GO:0005634,GO:0007156,GO:0007416,GO:0008150,GO:0010842,GO:0030018,GO:0045202" protein binding|nucleus|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|biological_process|retina layer formation|Z disc|synapse IGHMBP2 442.9894322 445.5656701 440.4131942 0.988436102 -0.01678039 0.974178345 1 3.183288098 3.282014343 3508 immunoglobulin mu DNA binding protein 2 "GO:0000049,GO:0003677,GO:0003678,GO:0003697,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006281,GO:0006310,GO:0006412,GO:0008094,GO:0008134,GO:0008186,GO:0008270,GO:0016020,GO:0016604,GO:0030424,GO:0030426,GO:0032508,GO:0032574,GO:0042802,GO:0043022,GO:0043139,GO:1990904" tRNA binding|DNA binding|DNA helicase activity|single-stranded DNA binding|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|DNA replication|DNA repair|DNA recombination|translation|DNA-dependent ATPase activity|transcription factor binding|RNA-dependent ATPase activity|zinc ion binding|membrane|nuclear body|axon|growth cone|DNA duplex unwinding|5'-3' RNA helicase activity|identical protein binding|ribosome binding|5'-3' DNA helicase activity|ribonucleoprotein complex IGIP 184.9961373 118.7498483 251.2424262 2.115728397 1.081154436 0.051897798 1 1.740237527 3.840469978 492311 IgA inducing protein GO:0005576 extracellular region IGLL1 12.52364607 14.20938356 10.83790858 0.762728977 -0.390757585 0.812815113 1 0.812251862 0.646214786 3543 immunoglobulin lambda like polypeptide 1 "GO:0003823,GO:0005515,GO:0005576,GO:0005783,GO:0006910,GO:0006911,GO:0006955,GO:0006958,GO:0009897,GO:0016020,GO:0034987,GO:0042571,GO:0042742,GO:0045087,GO:0050853,GO:0050871,GO:0050900" "antigen binding|protein binding|extracellular region|endoplasmic reticulum|phagocytosis, recognition|phagocytosis, engulfment|immune response|complement activation, classical pathway|external side of plasma membrane|membrane|immunoglobulin receptor binding|immunoglobulin complex, circulating|defense response to bacterium|innate immune response|B cell receptor signaling pathway|positive regulation of B cell activation|leukocyte migration" hsa05340 Primary immunodeficiency IGSF10 280.3035211 235.4697847 325.1372575 1.380802458 0.465506938 0.336122679 1 1.143843651 1.647457225 285313 immunoglobulin superfamily member 10 "GO:0001503,GO:0005576,GO:0007275,GO:0030154,GO:2001222" ossification|extracellular region|multicellular organism development|cell differentiation|regulation of neuron migration IGSF22 11.97163076 10.14955968 13.79370183 1.359044359 0.442592546 0.785314006 1 0.119934529 0.170017567 283284 immunoglobulin superfamily member 22 IGSF3 1538.313974 1436.162695 1640.465254 1.142255859 0.191885843 0.562139672 1 8.309902209 9.900912838 3321 immunoglobulin superfamily member 3 "GO:0003674,GO:0009986,GO:0016021,GO:0032808" molecular_function|cell surface|integral component of membrane|lacrimal gland development IGSF8 974.6214864 1091.077666 858.1653068 0.786529991 -0.346426317 0.32791705 1 11.1747694 9.167898299 93185 immunoglobulin superfamily member 8 "GO:0005515,GO:0005886,GO:0007338,GO:0007399,GO:0007519,GO:0016020,GO:0016021,GO:0043231,GO:0048870,GO:0070062" protein binding|plasma membrane|single fertilization|nervous system development|skeletal muscle tissue development|membrane|integral component of membrane|intracellular membrane-bounded organelle|cell motility|extracellular exosome IK 2414.221467 2447.05884 2381.384095 0.973161763 -0.039248459 0.903403324 1 65.05768899 66.03886466 3550 IK cytokine "GO:0000228,GO:0000278,GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007094,GO:0016032,GO:0016607,GO:0034501,GO:0042802,GO:0071005,GO:0097431" "nuclear chromosome|mitotic cell cycle|mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|cytoplasm|mitotic spindle assembly checkpoint|viral process|nuclear speck|protein localization to kinetochore|identical protein binding|U2-type precatalytic spliceosome|mitotic spindle pole" IKBIP 1312.525119 1424.99818 1200.052059 0.842142872 -0.247863084 0.463118248 1 18.80435922 16.51810589 121457 IKBKB interacting protein "GO:0005515,GO:0005783,GO:0005789,GO:0010165,GO:0016020,GO:0016021" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|response to X-ray|membrane|integral component of membrane IKBKB 833.5601742 776.4413158 890.6790326 1.147129879 0.198028744 0.588113515 1 6.699150515 8.015825552 3551 inhibitor of nuclear factor kappa B kinase subunit beta "GO:0002223,GO:0002479,GO:0002756,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0006954,GO:0007249,GO:0007252,GO:0008384,GO:0008385,GO:0009615,GO:0009898,GO:0010803,GO:0016032,GO:0018105,GO:0019901,GO:0030866,GO:0033209,GO:0035509,GO:0035631,GO:0035666,GO:0038095,GO:0042325,GO:0042802,GO:0042803,GO:0043066,GO:0043123,GO:0045087,GO:0045121,GO:0045893,GO:0045944,GO:0046982,GO:0050852,GO:0051092,GO:0051403,GO:0070498,GO:0071356,GO:0072659,GO:0097110,GO:0106310,GO:0106311,GO:1903140,GO:1903347,GO:1990459" "stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|MyD88-independent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|inflammatory response|I-kappaB kinase/NF-kappaB signaling|I-kappaB phosphorylation|IkappaB kinase activity|IkappaB kinase complex|response to virus|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|viral process|peptidyl-serine phosphorylation|protein kinase binding|cortical actin cytoskeleton organization|tumor necrosis factor-mediated signaling pathway|negative regulation of myosin-light-chain-phosphatase activity|CD40 receptor complex|TRIF-dependent toll-like receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of phosphorylation|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|membrane raft|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|cellular response to tumor necrosis factor|protein localization to plasma membrane|scaffold protein binding|protein serine kinase activity|protein threonine kinase activity|regulation of establishment of endothelial barrier|negative regulation of bicellular tight junction assembly|transferrin receptor binding" "hsa01523,hsa04010,hsa04014,hsa04062,hsa04064,hsa04068,hsa04150,hsa04151,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04910,hsa04920,hsa04930,hsa04931,hsa04932,hsa05010,hsa05120,hsa05130,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05206,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05235,hsa05418" Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|Alzheimer disease|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis IKBKE 1035.436451 1308.278243 762.5946584 0.582899442 -0.778681073 0.026729786 0.723144747 18.46702277 11.22810471 9641 inhibitor of nuclear factor kappa B kinase subunit epsilon "GO:0004672,GO:0004674,GO:0004704,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006955,GO:0007252,GO:0008384,GO:0008630,GO:0010008,GO:0010884,GO:0016032,GO:0016605,GO:0018105,GO:0019903,GO:0031625,GO:0031966,GO:0032480,GO:0034340,GO:0035456,GO:0035666,GO:0036435,GO:0038061,GO:0042802,GO:0043123,GO:0060340,GO:0070530,GO:0098586" protein kinase activity|protein serine/threonine kinase activity|NF-kappaB-inducing kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|immune response|I-kappaB phosphorylation|IkappaB kinase activity|intrinsic apoptotic signaling pathway in response to DNA damage|endosome membrane|positive regulation of lipid storage|viral process|PML body|peptidyl-serine phosphorylation|protein phosphatase binding|ubiquitin protein ligase binding|mitochondrial membrane|negative regulation of type I interferon production|response to type I interferon|response to interferon-beta|TRIF-dependent toll-like receptor signaling pathway|K48-linked polyubiquitin modification-dependent protein binding|NIK/NF-kappaB signaling|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of type I interferon-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|cellular response to virus "hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171" Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 IKBKG 219.6085606 194.8715459 244.3455753 1.253880212 0.326399528 0.535455255 1 3.856802007 5.044281594 8517 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma "GO:0000151,GO:0000187,GO:0000922,GO:0002223,GO:0002479,GO:0002756,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0006954,GO:0006955,GO:0006974,GO:0007249,GO:0007254,GO:0008385,GO:0009615,GO:0010803,GO:0016032,GO:0016239,GO:0016579,GO:0019904,GO:0031625,GO:0032991,GO:0035666,GO:0038095,GO:0042802,GO:0042803,GO:0042975,GO:0043122,GO:0043123,GO:0043276,GO:0044877,GO:0045087,GO:0045944,GO:0046872,GO:0046982,GO:0050852,GO:0051092,GO:0051403,GO:0051650,GO:0065003,GO:0070423,GO:0070498,GO:0070530,GO:0072686,GO:1901215,GO:1990450,GO:1990459" "ubiquitin ligase complex|activation of MAPK activity|spindle pole|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|MyD88-independent toll-like receptor signaling pathway|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|inflammatory response|immune response|cellular response to DNA damage stimulus|I-kappaB kinase/NF-kappaB signaling|JNK cascade|IkappaB kinase complex|response to virus|regulation of tumor necrosis factor-mediated signaling pathway|viral process|positive regulation of macroautophagy|protein deubiquitination|protein domain specific binding|ubiquitin protein ligase binding|protein-containing complex|TRIF-dependent toll-like receptor signaling pathway|Fc-epsilon receptor signaling pathway|identical protein binding|protein homodimerization activity|peroxisome proliferator activated receptor binding|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|anoikis|protein-containing complex binding|innate immune response|positive regulation of transcription by RNA polymerase II|metal ion binding|protein heterodimerization activity|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|establishment of vesicle localization|protein-containing complex assembly|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|mitotic spindle|negative regulation of neuron death|linear polyubiquitin binding|transferrin receptor binding" "hsa01523,hsa04010,hsa04014,hsa04062,hsa04064,hsa04151,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04920,hsa05120,hsa05130,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05235,hsa05340,hsa05418" Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Primary immunodeficiency|Fluid shear stress and atherosclerosis IKZF2 62.03652348 64.95718198 59.11586499 0.910074347 -0.135943686 0.882931413 1 0.191560039 0.181843474 22807 IKAROS family zinc finger 2 "GO:0000978,GO:0003674,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|molecular_function|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding IKZF4 183.5721805 189.7967661 177.347595 0.934407886 -0.097875645 0.868876101 1 1.347425938 1.313279993 64375 IKAROS family zinc finger 4 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008270,GO:0016604,GO:0019904,GO:0032991,GO:0043425,GO:0045892,GO:0045944,GO:0051260" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|zinc ion binding|nuclear body|protein domain specific binding|protein-containing complex|bHLH transcription factor binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein homooligomerization" IKZF5 251.5648278 257.798816 245.3308397 0.951636798 -0.071517036 0.893998993 1 2.499827794 2.481402693 64376 IKAROS family zinc finger 5 "GO:0000122,GO:0000977,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0008270,GO:0019904,GO:0032991" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|protein domain specific binding|protein-containing complex" IL10RB 908.3430304 870.8322209 945.8538399 1.086149338 0.119222477 0.74149734 1 22.72260684 25.74326489 3588 interleukin 10 receptor subunit beta "GO:0004896,GO:0004920,GO:0005515,GO:0005886,GO:0006954,GO:0006955,GO:0007165,GO:0016021,GO:0019221,GO:0032002,GO:0038023,GO:0046427,GO:0051607" cytokine receptor activity|interleukin-10 receptor activity|protein binding|plasma membrane|inflammatory response|immune response|signal transduction|integral component of membrane|cytokine-mediated signaling pathway|interleukin-28 receptor complex|signaling receptor activity|positive regulation of receptor signaling pathway via JAK-STAT|defense response to virus "hsa04060,hsa04061,hsa04630,hsa05145,hsa05152,hsa05163" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway|Toxoplasmosis|Tuberculosis|Human cytomegalovirus infection IL11 511.7310492 665.8111153 357.6509832 0.537165834 -0.896560548 0.027962662 0.739737908 14.18039703 7.945343955 3589 interleukin 11 "GO:0005125,GO:0005142,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0008083,GO:0008284,GO:0019221,GO:0030183,GO:0030219,GO:0033138,GO:0043410,GO:0045444,GO:0045944,GO:0046888,GO:0050731,GO:1903659,GO:2000352" cytokine activity|interleukin-11 receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|growth factor activity|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|B cell differentiation|megakaryocyte differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of MAPK cascade|fat cell differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of hormone secretion|positive regulation of peptidyl-tyrosine phosphorylation|regulation of complement-dependent cytotoxicity|negative regulation of endothelial cell apoptotic process "hsa04060,hsa04630,hsa04640,hsa05323" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Hematopoietic cell lineage|Rheumatoid arthritis IL11RA 129.1032895 137.0190557 121.1875232 0.88445744 -0.177135373 0.785564569 1 4.029925551 3.717833122 3590 interleukin 11 receptor subunit alpha "GO:0004888,GO:0004896,GO:0004921,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0008284,GO:0009897,GO:0019221,GO:0019955,GO:0019970,GO:0032502,GO:0038154,GO:0043235,GO:0060322" transmembrane signaling receptor activity|cytokine receptor activity|interleukin-11 receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|positive regulation of cell population proliferation|external side of plasma membrane|cytokine-mediated signaling pathway|cytokine binding|interleukin-11 binding|developmental process|interleukin-11-mediated signaling pathway|receptor complex|head development "hsa04060,hsa04630,hsa04640" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Hematopoietic cell lineage IL12A 8.030573092 10.14955968 5.911586499 0.582447582 -0.779799875 0.654071524 1 0.355982959 0.216272841 3592 interleukin 12A "GO:0001916,GO:0002860,GO:0005125,GO:0005143,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006955,GO:0007050,GO:0008083,GO:0009615,GO:0010224,GO:0016032,GO:0016477,GO:0019221,GO:0031906,GO:0032496,GO:0032700,GO:0032729,GO:0032816,GO:0032946,GO:0034393,GO:0035722,GO:0042163,GO:0042531,GO:0043514,GO:0045513,GO:0045785,GO:0045954,GO:0046982,GO:0048662,GO:0050671,GO:0050709,GO:0050830,GO:0051135,GO:0070757,GO:0097191,GO:0098586,GO:1900747,GO:1903588,GO:2000510" positive regulation of T cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|cytokine activity|interleukin-12 receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|immune response|cell cycle arrest|growth factor activity|response to virus|response to UV-B|viral process|cell migration|cytokine-mediated signaling pathway|late endosome lumen|response to lipopolysaccharide|negative regulation of interleukin-17 production|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of mononuclear cell proliferation|positive regulation of smooth muscle cell apoptotic process|interleukin-12-mediated signaling pathway|interleukin-12 beta subunit binding|positive regulation of tyrosine phosphorylation of STAT protein|interleukin-12 complex|interleukin-27 binding|positive regulation of cell adhesion|positive regulation of natural killer cell mediated cytotoxicity|protein heterodimerization activity|negative regulation of smooth muscle cell proliferation|positive regulation of lymphocyte proliferation|negative regulation of protein secretion|defense response to Gram-positive bacterium|positive regulation of NK T cell activation|interleukin-35-mediated signaling pathway|extrinsic apoptotic signaling pathway|cellular response to virus|negative regulation of vascular endothelial growth factor signaling pathway|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of dendritic cell chemotaxis "hsa04060,hsa04620,hsa04622,hsa04625,hsa04630,hsa04658,hsa04940,hsa05133,hsa05134,hsa05140,hsa05142,hsa05143,hsa05144,hsa05145,hsa05146,hsa05152,hsa05162,hsa05164,hsa05168,hsa05171,hsa05200,hsa05321,hsa05330" Cytokine-cytokine receptor interaction|Toll-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Type I diabetes mellitus|Pertussis|Legionellosis|Leishmaniasis|Chagas disease|African trypanosomiasis|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Measles|Influenza A|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Inflammatory bowel disease|Allograft rejection IL12RB1 14.91257823 9.134603715 20.69055275 2.265073931 1.17955814 0.344101402 1 0.114797879 0.271226535 3594 interleukin 12 receptor subunit beta 1 "GO:0001916,GO:0002230,GO:0002827,GO:0004896,GO:0005143,GO:0005886,GO:0007165,GO:0009897,GO:0016517,GO:0019221,GO:0019955,GO:0032729,GO:0035722,GO:0038155,GO:0042019,GO:0042020,GO:0042022,GO:0042104,GO:0043235,GO:0043382,GO:0071346,GO:0072536,GO:2000318,GO:2000330" positive regulation of T cell mediated cytotoxicity|positive regulation of defense response to virus by host|positive regulation of T-helper 1 type immune response|cytokine receptor activity|interleukin-12 receptor binding|plasma membrane|signal transduction|external side of plasma membrane|interleukin-12 receptor activity|cytokine-mediated signaling pathway|cytokine binding|positive regulation of interferon-gamma production|interleukin-12-mediated signaling pathway|interleukin-23-mediated signaling pathway|interleukin-23 binding|interleukin-23 receptor activity|interleukin-12 receptor complex|positive regulation of activated T cell proliferation|receptor complex|positive regulation of memory T cell differentiation|cellular response to interferon-gamma|interleukin-23 receptor complex|positive regulation of T-helper 17 type immune response|positive regulation of T-helper 17 cell lineage commitment "hsa04060,hsa04630,hsa04658,hsa04659,hsa05200,hsa05321" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Pathways in cancer|Inflammatory bowel disease IL13RA1 1786.422212 1794.442152 1778.402272 0.991061356 -0.012953719 0.970110493 1 19.88233747 20.55341129 3597 interleukin 13 receptor subunit alpha 1 "GO:0004896,GO:0004923,GO:0004924,GO:0005127,GO:0005515,GO:0005886,GO:0005898,GO:0007166,GO:0008284,GO:0009897,GO:0019221,GO:0019955,GO:0038165,GO:0043235,GO:0048861" cytokine receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|ciliary neurotrophic factor receptor binding|protein binding|plasma membrane|interleukin-13 receptor complex|cell surface receptor signaling pathway|positive regulation of cell population proliferation|external side of plasma membrane|cytokine-mediated signaling pathway|cytokine binding|oncostatin-M-mediated signaling pathway|receptor complex|leukemia inhibitory factor signaling pathway "hsa04060,hsa04630,hsa05200" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Pathways in cancer IL13RA2 233.0593258 373.5037964 92.61485516 0.247962286 -2.011807386 0.000154062 0.02294672 14.13800422 3.656702831 3598 interleukin 13 receptor subunit alpha 2 "GO:0002638,GO:0004896,GO:0005515,GO:0005576,GO:0005615,GO:0009897,GO:0016021,GO:0016064,GO:0019221,GO:0019955,GO:0043235,GO:0043305" negative regulation of immunoglobulin production|cytokine receptor activity|protein binding|extracellular region|extracellular space|external side of plasma membrane|integral component of membrane|immunoglobulin mediated immune response|cytokine-mediated signaling pathway|cytokine binding|receptor complex|negative regulation of mast cell degranulation "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway IL15 48.88663322 41.6131947 56.16007174 1.349573666 0.432503728 0.624174579 1 0.897598598 1.263556572 3600 interleukin 15 "GO:0001819,GO:0001866,GO:0005125,GO:0005126,GO:0005515,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0006954,GO:0006955,GO:0007165,GO:0007260,GO:0007267,GO:0007568,GO:0008284,GO:0009986,GO:0014732,GO:0016607,GO:0030212,GO:0030225,GO:0032740,GO:0032819,GO:0032825,GO:0034105,GO:0035723,GO:0042102,GO:0042119,GO:0042531,GO:0045062,GO:0045580,GO:0048469,GO:0048535,GO:0048662,GO:0050691,GO:0050729,GO:0050731,GO:0050766,GO:0050778,GO:0071305,GO:0120163,GO:1904100" positive regulation of cytokine production|NK T cell proliferation|cytokine activity|cytokine receptor binding|protein binding|extracellular region|extracellular space|nucleoplasm|cytoplasm|endosome|Golgi apparatus|cytosol|inflammatory response|immune response|signal transduction|tyrosine phosphorylation of STAT protein|cell-cell signaling|aging|positive regulation of cell population proliferation|cell surface|skeletal muscle atrophy|nuclear speck|hyaluronan metabolic process|macrophage differentiation|positive regulation of interleukin-17 production|positive regulation of natural killer cell proliferation|positive regulation of natural killer cell differentiation|positive regulation of tissue remodeling|interleukin-15-mediated signaling pathway|positive regulation of T cell proliferation|neutrophil activation|positive regulation of tyrosine phosphorylation of STAT protein|extrathymic T cell selection|regulation of T cell differentiation|cell maturation|lymph node development|negative regulation of smooth muscle cell proliferation|regulation of defense response to virus by host|positive regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of phagocytosis|positive regulation of immune response|cellular response to vitamin D|negative regulation of cold-induced thermogenesis|positive regulation of protein O-linked glycosylation "hsa04060,hsa04630,hsa04668,hsa04672,hsa05166,hsa05200,hsa05323" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|TNF signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Pathways in cancer|Rheumatoid arthritis IL15RA 252.3368082 310.5765263 194.0970901 0.624957373 -0.678170304 0.175181921 1 5.276620399 3.439712764 3601 interleukin 15 receptor subunit alpha "GO:0000139,GO:0004896,GO:0005515,GO:0005615,GO:0005768,GO:0005789,GO:0005886,GO:0009986,GO:0016021,GO:0019901,GO:0030659,GO:0031965,GO:0035723,GO:0042010,GO:0050766" Golgi membrane|cytokine receptor activity|protein binding|extracellular space|endosome|endoplasmic reticulum membrane|plasma membrane|cell surface|integral component of membrane|protein kinase binding|cytoplasmic vesicle membrane|nuclear membrane|interleukin-15-mediated signaling pathway|interleukin-15 receptor activity|positive regulation of phagocytosis "hsa04060,hsa04630,hsa04672,hsa05166,hsa05200" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Pathways in cancer IL16 7.060154451 11.16451565 2.95579325 0.264748901 -1.917303399 0.254779046 1 0.05466918 0.01509707 3603 interleukin 16 "GO:0005125,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0005925,GO:0006955,GO:0016032,GO:0016607,GO:0019221,GO:0030595,GO:0032730,GO:0032735,GO:0032755,GO:0042609,GO:0050729,GO:0050930,GO:0051924,GO:0090543" cytokine activity|extracellular region|extracellular space|cytosol|plasma membrane|focal adhesion|immune response|viral process|nuclear speck|cytokine-mediated signaling pathway|leukocyte chemotaxis|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|CD4 receptor binding|positive regulation of inflammatory response|induction of positive chemotaxis|regulation of calcium ion transport|Flemming body hsa04060 Cytokine-cytokine receptor interaction IL17C 5.478337395 4.059823873 6.896850916 1.698805448 0.764520641 0.742562249 1 0.193977129 0.343724194 27189 interleukin 17C "GO:0005125,GO:0005576,GO:0005615,GO:0006954,GO:0007166,GO:0007267,GO:0097400" cytokine activity|extracellular region|extracellular space|inflammatory response|cell surface receptor signaling pathway|cell-cell signaling|interleukin-17-mediated signaling pathway "hsa04060,hsa04657" Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17D 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.050611033 0.068329063 53342 interleukin 17D "GO:0005125,GO:0005615,GO:0006954,GO:0007165,GO:0032725,GO:0032755,GO:0032757,GO:0042803,GO:0048018,GO:1900017,GO:1903707" cytokine activity|extracellular space|inflammatory response|signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|protein homodimerization activity|receptor ligand activity|positive regulation of cytokine production involved in inflammatory response|negative regulation of hemopoiesis "hsa04060,hsa04625,hsa04630,hsa04657,hsa04659" Cytokine-cytokine receptor interaction|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|IL-17 signaling pathway|Th17 cell differentiation IL17RA 1135.060242 1214.902294 1055.21819 0.868562184 -0.203298953 0.556537051 1 7.183109419 6.507727041 23765 interleukin 17 receptor A "GO:0002250,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006954,GO:0007166,GO:0030368,GO:0032747,GO:0032755,GO:0045087,GO:0072537,GO:0097400,GO:2000340" adaptive immune response|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|inflammatory response|cell surface receptor signaling pathway|interleukin-17 receptor activity|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|innate immune response|fibroblast activation|interleukin-17-mediated signaling pathway|positive regulation of chemokine (C-X-C motif) ligand 1 production "hsa04060,hsa04657" Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17RC 874.4041101 773.3964479 975.4117724 1.261205395 0.334803246 0.35408929 1 16.23955295 21.36366794 84818 interleukin 17 receptor C "GO:0005102,GO:0005515,GO:0005886,GO:0006954,GO:0009986,GO:0016021,GO:0030368,GO:0032755,GO:0050832,GO:0071621,GO:0097400,GO:1900017" signaling receptor binding|protein binding|plasma membrane|inflammatory response|cell surface|integral component of membrane|interleukin-17 receptor activity|positive regulation of interleukin-6 production|defense response to fungus|granulocyte chemotaxis|interleukin-17-mediated signaling pathway|positive regulation of cytokine production involved in inflammatory response "hsa04060,hsa04657" Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17RD 259.7587045 279.1128913 240.4045176 0.861316425 -0.215384752 0.667855537 1 1.53037602 1.374918041 54756 interleukin 17 receptor D "GO:0000139,GO:0000165,GO:0005654,GO:0005794,GO:0005886,GO:0010719,GO:0016021,GO:0019221,GO:0030368,GO:0030512" Golgi membrane|MAPK cascade|nucleoplasm|Golgi apparatus|plasma membrane|negative regulation of epithelial to mesenchymal transition|integral component of membrane|cytokine-mediated signaling pathway|interleukin-17 receptor activity|negative regulation of transforming growth factor beta receptor signaling pathway IL17RE 4.52276453 6.08973581 2.95579325 0.485372985 -1.042834281 0.660953233 1 0.142921054 0.072358198 132014 interleukin 17 receptor E "GO:0005515,GO:0005576,GO:0005737,GO:0005886,GO:0006954,GO:0016021,GO:0030368,GO:0097400" protein binding|extracellular region|cytoplasm|plasma membrane|inflammatory response|integral component of membrane|interleukin-17 receptor activity|interleukin-17-mediated signaling pathway "hsa04060,hsa04657" Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL18 689.1583163 603.8988012 774.4178314 1.282363585 0.358805363 0.344112806 1 26.7120907 35.73016216 3606 interleukin 18 "GO:0000165,GO:0001525,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006954,GO:0007267,GO:0008283,GO:0010744,GO:0014068,GO:0019221,GO:0030101,GO:0030155,GO:0030431,GO:0031663,GO:0032148,GO:0032602,GO:0032609,GO:0032616,GO:0032725,GO:0032729,GO:0032740,GO:0032819,GO:0034105,GO:0035655,GO:0042088,GO:0042092,GO:0042104,GO:0042119,GO:0042267,GO:0042531,GO:0042632,GO:0045515,GO:0045630,GO:0045662,GO:0045944,GO:0048661,GO:0050729,GO:0051092,GO:0051142,GO:0051897,GO:0070328,GO:0071407,GO:0120162,GO:0150078,GO:1901224,GO:2000556" MAPK cascade|angiogenesis|cytokine activity|protein binding|extracellular region|extracellular space|cytosol|inflammatory response|cell-cell signaling|cell population proliferation|positive regulation of macrophage derived foam cell differentiation|positive regulation of phosphatidylinositol 3-kinase signaling|cytokine-mediated signaling pathway|natural killer cell activation|regulation of cell adhesion|sleep|lipopolysaccharide-mediated signaling pathway|activation of protein kinase B activity|chemokine production|interferon-gamma production|interleukin-13 production|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-17 production|positive regulation of natural killer cell proliferation|positive regulation of tissue remodeling|interleukin-18-mediated signaling pathway|T-helper 1 type immune response|type 2 immune response|positive regulation of activated T cell proliferation|neutrophil activation|natural killer cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of STAT protein|cholesterol homeostasis|interleukin-18 receptor binding|positive regulation of T-helper 2 cell differentiation|negative regulation of myoblast differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle cell proliferation|positive regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|positive regulation of NK T cell proliferation|positive regulation of protein kinase B signaling|triglyceride homeostasis|cellular response to organic cyclic compound|positive regulation of cold-induced thermogenesis|positive regulation of neuroinflammatory response|positive regulation of NIK/NF-kappaB signaling|positive regulation of T-helper 1 cell cytokine production "hsa04060,hsa04061,hsa04621,hsa04623,hsa05130,hsa05131,hsa05132,hsa05134,hsa05135,hsa05143,hsa05144,hsa05152,hsa05164,hsa05321,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Legionellosis|Yersinia infection|African trypanosomiasis|Malaria|Tuberculosis|Influenza A|Inflammatory bowel disease|Rheumatoid arthritis IL18BP 129.9697877 128.899408 131.0401674 1.016607985 0.023763467 0.98340716 1 2.00870778 2.130032392 10068 interleukin 18 binding protein "GO:0005576,GO:0005615,GO:0035655,GO:0042007,GO:0042088,GO:0048019,GO:0070062,GO:0071345,GO:2000272" extracellular region|extracellular space|interleukin-18-mediated signaling pathway|interleukin-18 binding|T-helper 1 type immune response|receptor antagonist activity|extracellular exosome|cellular response to cytokine stimulus|negative regulation of signaling receptor activity IL18R1 8.5232053 10.14955968 6.896850916 0.679522179 -0.557407454 0.765908482 1 0.122244802 0.086646289 8809 interleukin 18 receptor 1 "GO:0004908,GO:0005515,GO:0005886,GO:0006954,GO:0006955,GO:0007165,GO:0030101,GO:0032729,GO:0035655,GO:0038023,GO:0042007,GO:0042008,GO:0045063,GO:0045092,GO:0050135,GO:0051092,GO:0061809,GO:0071345,GO:0120163,GO:1901224,GO:2000556" "interleukin-1 receptor activity|protein binding|plasma membrane|inflammatory response|immune response|signal transduction|natural killer cell activation|positive regulation of interferon-gamma production|interleukin-18-mediated signaling pathway|signaling receptor activity|interleukin-18 binding|interleukin-18 receptor activity|T-helper 1 cell differentiation|interleukin-18 receptor complex|NAD(P)+ nucleosidase activity|positive regulation of NF-kappaB transcription factor activity|NAD+ nucleotidase, cyclic ADP-ribose generating|cellular response to cytokine stimulus|negative regulation of cold-induced thermogenesis|positive regulation of NIK/NF-kappaB signaling|positive regulation of T-helper 1 cell cytokine production" "hsa04060,hsa04061,hsa04668,hsa05321" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|TNF signaling pathway|Inflammatory bowel disease IL1A 885.3362905 1082.958018 687.7145627 0.635033447 -0.655095516 0.069427791 1 26.08083841 17.27563731 3552 interleukin 1 alpha "GO:0001660,GO:0001819,GO:0002248,GO:0005125,GO:0005149,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006883,GO:0006915,GO:0006954,GO:0006955,GO:0008285,GO:0010575,GO:0010628,GO:0019221,GO:0032743,GO:0032755,GO:0032760,GO:0033092,GO:0034605,GO:0035234,GO:0045766,GO:0045840,GO:0045944,GO:0046688,GO:0050714,GO:0050999,GO:0051781,GO:0070498,GO:0071222,GO:0097192,GO:2001240" fever generation|positive regulation of cytokine production|connective tissue replacement involved in inflammatory response wound healing|cytokine activity|interleukin-1 receptor binding|copper ion binding|protein binding|extracellular region|extracellular space|cytosol|cellular sodium ion homeostasis|apoptotic process|inflammatory response|immune response|negative regulation of cell population proliferation|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|cytokine-mediated signaling pathway|positive regulation of interleukin-2 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of immature T cell proliferation in thymus|cellular response to heat|ectopic germ cell programmed cell death|positive regulation of angiogenesis|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|response to copper ion|positive regulation of protein secretion|regulation of nitric-oxide synthase activity|positive regulation of cell division|interleukin-1-mediated signaling pathway|cellular response to lipopolysaccharide|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04010,hsa04060,hsa04217,hsa04218,hsa04380,hsa04640,hsa04932,hsa04933,hsa04940,hsa05010,hsa05020,hsa05022,hsa05133,hsa05140,hsa05152,hsa05162,hsa05164,hsa05321,hsa05323,hsa05332,hsa05418" MAPK signaling pathway|Cytokine-cytokine receptor interaction|Necroptosis|Cellular senescence|Osteoclast differentiation|Hematopoietic cell lineage|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Type I diabetes mellitus|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pertussis|Leishmaniasis|Tuberculosis|Measles|Influenza A|Inflammatory bowel disease|Rheumatoid arthritis|Graft-versus-host disease|Fluid shear stress and atherosclerosis IL1B 12372.61828 10519.00366 14226.23291 1.352431597 0.435555627 0.204973138 1 339.1154846 478.3864381 3553 interleukin 1 beta "GO:0000165,GO:0000187,GO:0001660,GO:0001934,GO:0002711,GO:0005125,GO:0005149,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005829,GO:0006915,GO:0006954,GO:0006955,GO:0007165,GO:0007267,GO:0007566,GO:0008284,GO:0008285,GO:0010573,GO:0010575,GO:0010628,GO:0010718,GO:0010829,GO:0014805,GO:0019221,GO:0019904,GO:0030213,GO:0030335,GO:0030730,GO:0030949,GO:0031394,GO:0031622,GO:0031663,GO:0032308,GO:0032496,GO:0032725,GO:0032729,GO:0032743,GO:0032755,GO:0032757,GO:0033092,GO:0033129,GO:0034116,GO:0035066,GO:0035505,GO:0035690,GO:0042102,GO:0043122,GO:0043407,GO:0043491,GO:0045429,GO:0045766,GO:0045833,GO:0045840,GO:0045893,GO:0045917,GO:0046330,GO:0046627,GO:0046827,GO:0050729,GO:0050766,GO:0050767,GO:0050768,GO:0050796,GO:0050805,GO:0050995,GO:0050996,GO:0050999,GO:0051044,GO:0051091,GO:0051092,GO:0051781,GO:0060252,GO:0060355,GO:0060559,GO:0070164,GO:0070372,GO:0070487,GO:0070498,GO:0070555,GO:0071222,GO:0071260,GO:0071310,GO:0071407,GO:0071639,GO:0150078,GO:1900745,GO:1901224,GO:1902680,GO:1903140,GO:1903597,GO:2000556,GO:2001240" "MAPK cascade|activation of MAPK activity|fever generation|positive regulation of protein phosphorylation|positive regulation of T cell mediated immunity|cytokine activity|interleukin-1 receptor binding|integrin binding|protein binding|extracellular region|extracellular space|lysosome|cytosol|apoptotic process|inflammatory response|immune response|signal transduction|cell-cell signaling|embryo implantation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|vascular endothelial growth factor production|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of glucose transmembrane transport|smooth muscle adaptation|cytokine-mediated signaling pathway|protein domain specific binding|hyaluronan biosynthetic process|positive regulation of cell migration|sequestering of triglyceride|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of prostaglandin biosynthetic process|positive regulation of fever generation|lipopolysaccharide-mediated signaling pathway|positive regulation of prostaglandin secretion|response to lipopolysaccharide|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of immature T cell proliferation in thymus|positive regulation of histone phosphorylation|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of myosin light chain kinase activity|cellular response to drug|positive regulation of T cell proliferation|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of MAP kinase activity|protein kinase B signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of angiogenesis|negative regulation of lipid metabolic process|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|positive regulation of complement activation|positive regulation of JNK cascade|negative regulation of insulin receptor signaling pathway|positive regulation of protein export from nucleus|positive regulation of inflammatory response|positive regulation of phagocytosis|regulation of neurogenesis|negative regulation of neurogenesis|regulation of insulin secretion|negative regulation of synaptic transmission|negative regulation of lipid catabolic process|positive regulation of lipid catabolic process|regulation of nitric-oxide synthase activity|positive regulation of membrane protein ectodomain proteolysis|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of cell division|positive regulation of glial cell proliferation|positive regulation of cell adhesion molecule production|positive regulation of calcidiol 1-monooxygenase activity|negative regulation of adiponectin secretion|regulation of ERK1 and ERK2 cascade|monocyte aggregation|interleukin-1-mediated signaling pathway|response to interleukin-1|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to organic substance|cellular response to organic cyclic compound|positive regulation of monocyte chemotactic protein-1 production|positive regulation of neuroinflammatory response|positive regulation of p38MAPK cascade|positive regulation of NIK/NF-kappaB signaling|positive regulation of RNA biosynthetic process|regulation of establishment of endothelial barrier|negative regulation of gap junction assembly|positive regulation of T-helper 1 cell cytokine production|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa01523,hsa04010,hsa04060,hsa04064,hsa04217,hsa04380,hsa04620,hsa04621,hsa04623,hsa04625,hsa04640,hsa04657,hsa04659,hsa04668,hsa04750,hsa04932,hsa04933,hsa04940,hsa05010,hsa05020,hsa05022,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05143,hsa05144,hsa05146,hsa05152,hsa05162,hsa05163,hsa05164,hsa05168,hsa05171,hsa05321,hsa05323,hsa05332,hsa05418" Antifolate resistance|MAPK signaling pathway|Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|Hematopoietic cell lineage|IL-17 signaling pathway|Th17 cell differentiation|TNF signaling pathway|Inflammatory mediator regulation of TRP channels|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Type I diabetes mellitus|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|African trypanosomiasis|Malaria|Amoebiasis|Tuberculosis|Measles|Human cytomegalovirus infection|Influenza A|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19|Inflammatory bowel disease|Rheumatoid arthritis|Graft-versus-host disease|Fluid shear stress and atherosclerosis IL1R1 193.4666404 226.3351809 160.5980999 0.709558714 -0.495006027 0.364782501 1 1.706831217 1.263266108 3554 interleukin 1 receptor type 1 "GO:0002020,GO:0004888,GO:0004908,GO:0004909,GO:0005161,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007166,GO:0009897,GO:0016020,GO:0019221,GO:0019966,GO:0032729,GO:0050135,GO:0050727,GO:0061809,GO:0070498,GO:0070555,GO:2000391,GO:2000556,GO:2000661" "protease binding|transmembrane signaling receptor activity|interleukin-1 receptor activity|interleukin-1, type I, activating receptor activity|platelet-derived growth factor receptor binding|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|cell surface receptor signaling pathway|external side of plasma membrane|membrane|cytokine-mediated signaling pathway|interleukin-1 binding|positive regulation of interferon-gamma production|NAD(P)+ nucleosidase activity|regulation of inflammatory response|NAD+ nucleotidase, cyclic ADP-ribose generating|interleukin-1-mediated signaling pathway|response to interleukin-1|positive regulation of neutrophil extravasation|positive regulation of T-helper 1 cell cytokine production|positive regulation of interleukin-1-mediated signaling pathway" "hsa04010,hsa04060,hsa04064,hsa04380,hsa04640,hsa04659,hsa04750,hsa05130,hsa05131,hsa05146,hsa05163,hsa05166,hsa05418" MAPK signaling pathway|Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Osteoclast differentiation|Hematopoietic cell lineage|Th17 cell differentiation|Inflammatory mediator regulation of TRP channels|Pathogenic Escherichia coli infection|Shigellosis|Amoebiasis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Fluid shear stress and atherosclerosis IL1R2 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.024926143 0.018929445 7850 interleukin 1 receptor type 2 "GO:0004908,GO:0004910,GO:0005515,GO:0005576,GO:0005737,GO:0005886,GO:0006955,GO:0010955,GO:0016021,GO:0019221,GO:0019966,GO:0032690,GO:0070498,GO:1900016,GO:2000660" "interleukin-1 receptor activity|interleukin-1, type II, blocking receptor activity|protein binding|extracellular region|cytoplasm|plasma membrane|immune response|negative regulation of protein processing|integral component of membrane|cytokine-mediated signaling pathway|interleukin-1 binding|negative regulation of interleukin-1 alpha production|interleukin-1-mediated signaling pathway|negative regulation of cytokine production involved in inflammatory response|negative regulation of interleukin-1-mediated signaling pathway" "hsa04060,hsa04640,hsa05146,hsa05166,hsa05202,hsa05215,hsa05418" Cytokine-cytokine receptor interaction|Hematopoietic cell lineage|Amoebiasis|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer|Prostate cancer|Fluid shear stress and atherosclerosis IL1RAP 662.9542914 664.7961593 661.1124235 0.994458849 -0.008016421 0.987724669 1 3.11928666 3.235623897 3556 interleukin 1 receptor accessory protein "GO:0002114,GO:0004908,GO:0005149,GO:0005576,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0016020,GO:0019221,GO:0032736,GO:0032754,GO:0032755,GO:0038172,GO:0045087,GO:0050135,GO:0051092,GO:0051965,GO:0061809,GO:0065003,GO:0070498,GO:0098978,GO:0099151,GO:0099545,GO:0099560,GO:1905606" "interleukin-33 receptor activity|interleukin-1 receptor activity|interleukin-1 receptor binding|extracellular region|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|membrane|cytokine-mediated signaling pathway|positive regulation of interleukin-13 production|positive regulation of interleukin-5 production|positive regulation of interleukin-6 production|interleukin-33-mediated signaling pathway|innate immune response|NAD(P)+ nucleosidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of synapse assembly|NAD+ nucleotidase, cyclic ADP-ribose generating|protein-containing complex assembly|interleukin-1-mediated signaling pathway|glutamatergic synapse|regulation of postsynaptic density assembly|trans-synaptic signaling by trans-synaptic complex|synaptic membrane adhesion|regulation of presynapse assembly" "hsa04010,hsa04060,hsa04659,hsa04750" MAPK signaling pathway|Cytokine-cytokine receptor interaction|Th17 cell differentiation|Inflammatory mediator regulation of TRP channels IL1RAPL1 15.01649866 16.23929549 13.79370183 0.849402724 -0.235479359 0.899738079 1 0.093313255 0.082674755 11141 interleukin 1 receptor accessory protein like 1 "GO:0005102,GO:0005515,GO:0005737,GO:0005886,GO:0007157,GO:0007165,GO:0009986,GO:0010975,GO:0016021,GO:0019966,GO:0030182,GO:0030424,GO:0030425,GO:0045211,GO:0045920,GO:0050135,GO:0050775,GO:0051965,GO:0061809,GO:0071345,GO:0097105,GO:0098978,GO:0099175,GO:0099545,GO:1905606" "signaling receptor binding|protein binding|cytoplasm|plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|cell surface|regulation of neuron projection development|integral component of membrane|interleukin-1 binding|neuron differentiation|axon|dendrite|postsynaptic membrane|negative regulation of exocytosis|NAD(P)+ nucleosidase activity|positive regulation of dendrite morphogenesis|positive regulation of synapse assembly|NAD+ nucleotidase, cyclic ADP-ribose generating|cellular response to cytokine stimulus|presynaptic membrane assembly|glutamatergic synapse|regulation of postsynapse organization|trans-synaptic signaling by trans-synaptic complex|regulation of presynapse assembly" IL20 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.173193865 0.035073897 50604 interleukin 20 "GO:0005125,GO:0005576,GO:0005615,GO:0019221,GO:0042531,GO:0045517,GO:0045518,GO:0045606,GO:0045618,GO:0045672,GO:0050727" cytokine activity|extracellular region|extracellular space|cytokine-mediated signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|interleukin-20 receptor binding|interleukin-22 receptor binding|positive regulation of epidermal cell differentiation|positive regulation of keratinocyte differentiation|positive regulation of osteoclast differentiation|regulation of inflammatory response "hsa04060,hsa04061,hsa04630" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway IL20RA 6.000661155 6.08973581 5.911586499 0.970745971 -0.042834281 1 1 0.085554407 0.086629121 53832 interleukin 20 receptor subunit alpha "GO:0004896,GO:0005515,GO:0005886,GO:0016021,GO:0019221,GO:0042015,GO:0045124,GO:2001244" cytokine receptor activity|protein binding|plasma membrane|integral component of membrane|cytokine-mediated signaling pathway|interleukin-20 binding|regulation of bone resorption|positive regulation of intrinsic apoptotic signaling pathway "hsa04060,hsa04061,hsa04630" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway IL20RB 13.01627828 14.20938356 11.823173 0.832067975 -0.265226703 0.893085452 1 0.217813302 0.189042362 53833 interleukin 20 receptor subunit beta "GO:0001808,GO:0002437,GO:0002765,GO:0004896,GO:0005515,GO:0005886,GO:0016021,GO:0019221,GO:0032689,GO:0032703,GO:0032733,GO:0032753,GO:0042015,GO:0042130,GO:0048873" negative regulation of type IV hypersensitivity|inflammatory response to antigenic stimulus|immune response-inhibiting signal transduction|cytokine receptor activity|protein binding|plasma membrane|integral component of membrane|cytokine-mediated signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|positive regulation of interleukin-10 production|positive regulation of interleukin-4 production|interleukin-20 binding|negative regulation of T cell proliferation|homeostasis of number of cells within a tissue "hsa04060,hsa04061,hsa04630" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway IL22RA1 22.83923089 12.17947162 33.49899016 2.750446916 1.459666059 0.178168871 1 0.21477969 0.616186827 58985 interleukin 22 receptor subunit alpha 1 "GO:0004896,GO:0004904,GO:0005515,GO:0005886,GO:0008150,GO:0016021,GO:0019221,GO:0042015,GO:0050829" cytokine receptor activity|interferon receptor activity|protein binding|plasma membrane|biological_process|integral component of membrane|cytokine-mediated signaling pathway|interleukin-20 binding|defense response to Gram-negative bacterium "hsa04060,hsa04061,hsa04630" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway IL23A 9.523315492 11.16451565 7.882115332 0.705997069 -0.5022659 0.780585832 1 0.460084078 0.338809853 51561 interleukin 23 subunit alpha "GO:0001916,GO:0002230,GO:0002827,GO:0005125,GO:0005515,GO:0005576,GO:0005788,GO:0006954,GO:0010536,GO:0019221,GO:0032693,GO:0032725,GO:0032729,GO:0032733,GO:0032735,GO:0032740,GO:0032760,GO:0032816,GO:0032819,GO:0034105,GO:0038155,GO:0042098,GO:0042102,GO:0042104,GO:0042509,GO:0042531,GO:0043382,GO:0045087,GO:0045519,GO:0045672,GO:0045944,GO:0048771,GO:0050729,GO:0050829,GO:0051135,GO:0051142,GO:0051607,GO:0070743,GO:0090023,GO:1901224,GO:2000318,GO:2000330" positive regulation of T cell mediated cytotoxicity|positive regulation of defense response to virus by host|positive regulation of T-helper 1 type immune response|cytokine activity|protein binding|extracellular region|endoplasmic reticulum lumen|inflammatory response|positive regulation of activation of Janus kinase activity|cytokine-mediated signaling pathway|negative regulation of interleukin-10 production|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell activation|positive regulation of natural killer cell proliferation|positive regulation of tissue remodeling|interleukin-23-mediated signaling pathway|T cell proliferation|positive regulation of T cell proliferation|positive regulation of activated T cell proliferation|regulation of tyrosine phosphorylation of STAT protein|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of memory T cell differentiation|innate immune response|interleukin-23 receptor binding|positive regulation of osteoclast differentiation|positive regulation of transcription by RNA polymerase II|tissue remodeling|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|defense response to virus|interleukin-23 complex|positive regulation of neutrophil chemotaxis|positive regulation of NIK/NF-kappaB signaling|positive regulation of T-helper 17 type immune response|positive regulation of T-helper 17 cell lineage commitment "hsa04060,hsa04625,hsa04630,hsa04659,hsa05133,hsa05152,hsa05200,hsa05321,hsa05323" Cytokine-cytokine receptor interaction|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Th17 cell differentiation|Pertussis|Tuberculosis|Pathways in cancer|Inflammatory bowel disease|Rheumatoid arthritis IL24 74.43868174 104.5404647 44.33689874 0.424112317 -1.237481712 0.099777129 1 2.623689664 1.160671391 11009 interleukin 24 "GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0006915,GO:0008284,GO:0008285,GO:0019221,GO:0030336,GO:0042060,GO:0042501,GO:0042531,GO:0071222,GO:0071353" cytokine activity|protein binding|extracellular region|extracellular space|apoptotic process|positive regulation of cell population proliferation|negative regulation of cell population proliferation|cytokine-mediated signaling pathway|negative regulation of cell migration|wound healing|serine phosphorylation of STAT protein|positive regulation of tyrosine phosphorylation of STAT protein|cellular response to lipopolysaccharide|cellular response to interleukin-4 "hsa04060,hsa04061,hsa04630" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway IL27RA 670.3843525 532.8518834 807.9168216 1.516212754 0.600472206 0.11564726 1 9.14815868 14.46804212 9466 interleukin 27 receptor subunit alpha "GO:0002827,GO:0002829,GO:0004888,GO:0004896,GO:0005143,GO:0005515,GO:0005886,GO:0005887,GO:0006955,GO:0007166,GO:0009897,GO:0019221,GO:0019955,GO:0032700,GO:0032715,GO:0032720,GO:0032729,GO:0042019,GO:0042022,GO:0042104,GO:0043235,GO:0045509,GO:0048302,GO:0050830,GO:0070106,GO:0070757,GO:0072536,GO:2000317,GO:2000408" positive regulation of T-helper 1 type immune response|negative regulation of type 2 immune response|transmembrane signaling receptor activity|cytokine receptor activity|interleukin-12 receptor binding|protein binding|plasma membrane|integral component of plasma membrane|immune response|cell surface receptor signaling pathway|external side of plasma membrane|cytokine-mediated signaling pathway|cytokine binding|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of interferon-gamma production|interleukin-23 binding|interleukin-12 receptor complex|positive regulation of activated T cell proliferation|receptor complex|interleukin-27 receptor activity|regulation of isotype switching to IgG isotypes|defense response to Gram-positive bacterium|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway|interleukin-23 receptor complex|negative regulation of T-helper 17 type immune response|negative regulation of T cell extravasation "hsa04060,hsa04630,hsa04659" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Th17 cell differentiation IL31RA 1180.865635 1146.900244 1214.831026 1.059229895 0.083015746 0.810640183 1 6.460510661 7.13794187 133396 interleukin 31 receptor A "GO:0000165,GO:0002067,GO:0002438,GO:0003713,GO:0004896,GO:0005886,GO:0006952,GO:0007169,GO:0007259,GO:0008284,GO:0009897,GO:0016021,GO:0019221,GO:0019901,GO:0019955,GO:0030224,GO:0030225,GO:0030424,GO:0042531,GO:0042592,GO:0042734,GO:0043031,GO:0043066,GO:0043235,GO:0045893,GO:0051916,GO:0098542" "MAPK cascade|glandular epithelial cell differentiation|acute inflammatory response to antigenic stimulus|transcription coactivator activity|cytokine receptor activity|plasma membrane|defense response|transmembrane receptor protein tyrosine kinase signaling pathway|receptor signaling pathway via JAK-STAT|positive regulation of cell population proliferation|external side of plasma membrane|integral component of membrane|cytokine-mediated signaling pathway|protein kinase binding|cytokine binding|monocyte differentiation|macrophage differentiation|axon|positive regulation of tyrosine phosphorylation of STAT protein|homeostatic process|presynaptic membrane|negative regulation of macrophage activation|negative regulation of apoptotic process|receptor complex|positive regulation of transcription, DNA-templated|granulocyte colony-stimulating factor binding|defense response to other organism" hsa04060 Cytokine-cytokine receptor interaction IL32 7.030462899 9.134603715 4.926322083 0.539303317 -0.890831188 0.625563046 1 0.496389971 0.279236393 9235 interleukin 32 "GO:0005125,GO:0005515,GO:0005615,GO:0005829,GO:0006952,GO:0006955,GO:0007155,GO:0016020,GO:0019221" cytokine activity|protein binding|extracellular space|cytosol|defense response|immune response|cell adhesion|membrane|cytokine-mediated signaling pathway hsa04060 Cytokine-cytokine receptor interaction IL33 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.029066406 0.044147297 90865 interleukin 33 "GO:0000122,GO:0001819,GO:0002112,GO:0002282,GO:0002638,GO:0002639,GO:0002686,GO:0002826,GO:0002830,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0010186,GO:0010628,GO:0016579,GO:0030133,GO:0032436,GO:0032689,GO:0032722,GO:0032736,GO:0032753,GO:0032754,GO:0032755,GO:0032760,GO:0038172,GO:0043032,GO:0043231,GO:0045345,GO:0045348,GO:0045944,GO:0050729,GO:0051607,GO:0051770,GO:0061518,GO:0097191,GO:0120042,GO:0150078,GO:0150142,GO:0150145" negative regulation of transcription by RNA polymerase II|positive regulation of cytokine production|interleukin-33 receptor binding|microglial cell activation involved in immune response|negative regulation of immunoglobulin production|positive regulation of immunoglobulin production|negative regulation of leukocyte migration|negative regulation of T-helper 1 type immune response|positive regulation of type 2 immune response|cytokine activity|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|chromosome|cytoplasm|positive regulation of cellular defense response|positive regulation of gene expression|protein deubiquitination|transport vesicle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of interferon-gamma production|positive regulation of chemokine production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|interleukin-33-mediated signaling pathway|positive regulation of macrophage activation|intracellular membrane-bounded organelle|positive regulation of MHC class I biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of transcription by RNA polymerase II|positive regulation of inflammatory response|defense response to virus|positive regulation of nitric-oxide synthase biosynthetic process|microglial cell proliferation|extrinsic apoptotic signaling pathway|negative regulation of macrophage proliferation|positive regulation of neuroinflammatory response|positive regulation of CD86 production|positive regulation of CD80 production "hsa04060,hsa04217,hsa04623,hsa05164" Cytokine-cytokine receptor interaction|Necroptosis|Cytosolic DNA-sensing pathway|Influenza A IL36G 4.537610306 7.104691779 1.970528833 0.277355992 -1.850189203 0.383956367 1 0.297132597 0.085961459 56300 interleukin 36 gamma "GO:0002437,GO:0005125,GO:0005149,GO:0005576,GO:0005615,GO:0005737,GO:0006954,GO:0007267,GO:0010628,GO:0019221,GO:0045087,GO:0071222" inflammatory response to antigenic stimulus|cytokine activity|interleukin-1 receptor binding|extracellular region|extracellular space|cytoplasm|inflammatory response|cell-cell signaling|positive regulation of gene expression|cytokine-mediated signaling pathway|innate immune response|cellular response to lipopolysaccharide hsa04060 Cytokine-cytokine receptor interaction IL4I1 71.98764487 139.0489677 4.926322083 0.035428685 -4.818938269 4.30E-07 0.000208098 2.862739706 0.105791999 259307 interleukin 4 induced 1 "GO:0001669,GO:0001716,GO:0002250,GO:0005515,GO:0005576,GO:0005764,GO:0006559,GO:0009063,GO:0016491,GO:0046592,GO:0055114" acrosomal vesicle|L-amino-acid oxidase activity|adaptive immune response|protein binding|extracellular region|lysosome|L-phenylalanine catabolic process|cellular amino acid catabolic process|oxidoreductase activity|polyamine oxidase activity|oxidation-reduction process "hsa00250,hsa00270,hsa00280,hsa00350,hsa00360,hsa00380,hsa00400" "Alanine, aspartate and glutamate metabolism|Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation|Tyrosine metabolism|Phenylalanine metabolism|Tryptophan metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis" IL4R 915.4274332 951.0137424 879.841124 0.925161314 -0.112223154 0.756003397 1 8.533928256 8.235356076 3566 interleukin 4 receptor "GO:0002532,GO:0002639,GO:0004913,GO:0005515,GO:0005615,GO:0005654,GO:0005886,GO:0005887,GO:0006955,GO:0007165,GO:0016064,GO:0019221,GO:0030728,GO:0032722,GO:0034451,GO:0035771,GO:0042127,GO:0042832,GO:0043032,GO:0043235,GO:0043306,GO:0043627,GO:0045626,GO:0045630,GO:0120162,GO:1901741,GO:1990834" production of molecular mediator involved in inflammatory response|positive regulation of immunoglobulin production|interleukin-4 receptor activity|protein binding|extracellular space|nucleoplasm|plasma membrane|integral component of plasma membrane|immune response|signal transduction|immunoglobulin mediated immune response|cytokine-mediated signaling pathway|ovulation|positive regulation of chemokine production|centriolar satellite|interleukin-4-mediated signaling pathway|regulation of cell population proliferation|defense response to protozoan|positive regulation of macrophage activation|receptor complex|positive regulation of mast cell degranulation|response to estrogen|negative regulation of T-helper 1 cell differentiation|positive regulation of T-helper 2 cell differentiation|positive regulation of cold-induced thermogenesis|positive regulation of myoblast fusion|response to odorant "hsa04060,hsa04151,hsa04630,hsa04640,hsa04658,hsa04659,hsa05200,hsa05321" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Pathways in cancer|Inflammatory bowel disease IL6 4337.357162 5336.638482 3338.075843 0.625501588 -0.676914549 0.034662439 0.835969212 159.3643352 103.9765688 3569 interleukin 6 "GO:0001781,GO:0002314,GO:0002377,GO:0002384,GO:0002446,GO:0002548,GO:0002639,GO:0002675,GO:0002690,GO:0005125,GO:0005138,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005896,GO:0006953,GO:0006954,GO:0006959,GO:0008083,GO:0008284,GO:0008285,GO:0010573,GO:0010574,GO:0010575,GO:0010628,GO:0010718,GO:0010888,GO:0014823,GO:0019221,GO:0030168,GO:0031018,GO:0031175,GO:0032494,GO:0032625,GO:0032682,GO:0032722,GO:0032731,GO:0032733,GO:0032740,GO:0032755,GO:0032757,GO:0032760,GO:0032966,GO:0033138,GO:0035633,GO:0042102,GO:0042531,GO:0042593,GO:0043065,GO:0043066,GO:0043410,GO:0043687,GO:0044267,GO:0045599,GO:0045669,GO:0045727,GO:0045765,GO:0045779,GO:0045893,GO:0045944,GO:0046427,GO:0048661,GO:0050731,GO:0050768,GO:0050796,GO:0050829,GO:0050830,GO:0050871,GO:0051091,GO:0051092,GO:0051384,GO:0051607,GO:0060252,GO:0061470,GO:0061888,GO:0070050,GO:0070091,GO:0070092,GO:0070102,GO:0070301,GO:0071222,GO:0072540,GO:0072574,GO:0090091,GO:0097421,GO:0098586,GO:0150077,GO:0150078,GO:1900017,GO:1902512,GO:1903800,GO:1903978,GO:1904894,GO:1904996,GO:2000553,GO:2000635,GO:2000660,GO:2000676" "neutrophil apoptotic process|germinal center B cell differentiation|immunoglobulin production|hepatic immune response|neutrophil mediated immunity|monocyte chemotaxis|positive regulation of immunoglobulin production|positive regulation of acute inflammatory response|positive regulation of leukocyte chemotaxis|cytokine activity|interleukin-6 receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|interleukin-6 receptor complex|acute-phase response|inflammatory response|humoral immune response|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|vascular endothelial growth factor production|regulation of vascular endothelial growth factor production|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of lipid storage|response to activity|cytokine-mediated signaling pathway|platelet activation|endocrine pancreas development|neuron projection development|response to peptidoglycan|interleukin-21 production|negative regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|negative regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|maintenance of blood-brain barrier|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|glucose homeostasis|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of MAPK cascade|post-translational protein modification|cellular protein metabolic process|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of translation|regulation of angiogenesis|negative regulation of bone resorption|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of receptor signaling pathway via JAK-STAT|positive regulation of smooth muscle cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of neurogenesis|regulation of insulin secretion|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|positive regulation of B cell activation|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|response to glucocorticoid|defense response to virus|positive regulation of glial cell proliferation|T follicular helper cell differentiation|regulation of astrocyte activation|neuron cellular homeostasis|glucagon secretion|regulation of glucagon secretion|interleukin-6-mediated signaling pathway|cellular response to hydrogen peroxide|cellular response to lipopolysaccharide|T-helper 17 cell lineage commitment|hepatocyte proliferation|positive regulation of extracellular matrix disassembly|liver regeneration|cellular response to virus|regulation of neuroinflammatory response|positive regulation of neuroinflammatory response|positive regulation of cytokine production involved in inflammatory response|positive regulation of apoptotic DNA fragmentation|positive regulation of production of miRNAs involved in gene silencing by miRNA|regulation of microglial cell activation|positive regulation of receptor signaling pathway via STAT|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of T-helper 2 cell cytokine production|negative regulation of primary miRNA processing|negative regulation of interleukin-1-mediated signaling pathway|positive regulation of type B pancreatic cell apoptotic process" "hsa01521,hsa01523,hsa04060,hsa04061,hsa04066,hsa04068,hsa04151,hsa04218,hsa04620,hsa04621,hsa04623,hsa04625,hsa04630,hsa04640,hsa04657,hsa04659,hsa04668,hsa04672,hsa04931,hsa04932,hsa04933,hsa05010,hsa05020,hsa05022,hsa05130,hsa05132,hsa05133,hsa05134,hsa05135,hsa05142,hsa05143,hsa05144,hsa05146,hsa05152,hsa05161,hsa05162,hsa05163,hsa05164,hsa05166,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200,hsa05202,hsa05321,hsa05323,hsa05332,hsa05410" EGFR tyrosine kinase inhibitor resistance|Antifolate resistance|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|HIF-1 signaling pathway|FoxO signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|IL-17 signaling pathway|Th17 cell differentiation|TNF signaling pathway|Intestinal immune network for IgA production|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Chagas disease|African trypanosomiasis|Malaria|Amoebiasis|Tuberculosis|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Transcriptional misregulation in cancer|Inflammatory bowel disease|Rheumatoid arthritis|Graft-versus-host disease|Hypertrophic cardiomyopathy IL6R 28.21092625 42.62815067 13.79370183 0.32358199 -1.627796782 0.110582339 1 0.709485852 0.239466083 3570 interleukin 6 receptor "GO:0002384,GO:0002548,GO:0002690,GO:0004896,GO:0004897,GO:0004915,GO:0004921,GO:0005138,GO:0005515,GO:0005576,GO:0005886,GO:0005896,GO:0006953,GO:0008284,GO:0009897,GO:0010536,GO:0010573,GO:0016324,GO:0019221,GO:0019899,GO:0019955,GO:0019970,GO:0019981,GO:0031018,GO:0032722,GO:0032755,GO:0034097,GO:0038154,GO:0042531,GO:0042803,GO:0043235,GO:0045669,GO:0048661,GO:0050731,GO:0050829,GO:0070102,GO:0070110,GO:0070119,GO:0070120,GO:0072126,GO:0072540,GO:0097191" hepatic immune response|monocyte chemotaxis|positive regulation of leukocyte chemotaxis|cytokine receptor activity|ciliary neurotrophic factor receptor activity|interleukin-6 receptor activity|interleukin-11 receptor activity|interleukin-6 receptor binding|protein binding|extracellular region|plasma membrane|interleukin-6 receptor complex|acute-phase response|positive regulation of cell population proliferation|external side of plasma membrane|positive regulation of activation of Janus kinase activity|vascular endothelial growth factor production|apical plasma membrane|cytokine-mediated signaling pathway|enzyme binding|cytokine binding|interleukin-11 binding|interleukin-6 binding|endocrine pancreas development|positive regulation of chemokine production|positive regulation of interleukin-6 production|response to cytokine|interleukin-11-mediated signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|receptor complex|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-negative bacterium|interleukin-6-mediated signaling pathway|ciliary neurotrophic factor receptor complex|ciliary neurotrophic factor binding|ciliary neurotrophic factor-mediated signaling pathway|positive regulation of glomerular mesangial cell proliferation|T-helper 17 cell lineage commitment|extrinsic apoptotic signaling pathway "hsa01521,hsa04060,hsa04061,hsa04066,hsa04151,hsa04630,hsa04640,hsa04659,hsa04932,hsa05163,hsa05171,hsa05200" EGFR tyrosine kinase inhibitor resistance|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|HIF-1 signaling pathway|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|Th17 cell differentiation|Non-alcoholic fatty liver disease|Human cytomegalovirus infection|Coronavirus disease - COVID-19|Pathways in cancer IL6ST 5557.708341 5377.23672 5738.179962 1.067124298 0.093728231 0.771915959 1 30.01631987 33.41091606 3572 interleukin 6 cytokine family signal transducer "GO:0002675,GO:0002821,GO:0004896,GO:0004897,GO:0004915,GO:0004921,GO:0004923,GO:0004924,GO:0005127,GO:0005138,GO:0005515,GO:0005576,GO:0005886,GO:0005896,GO:0005900,GO:0005977,GO:0008284,GO:0009897,GO:0010575,GO:0010613,GO:0016020,GO:0016032,GO:0019221,GO:0019838,GO:0019955,GO:0019970,GO:0019981,GO:0030425,GO:0034097,GO:0038154,GO:0038165,GO:0042102,GO:0042531,GO:0042802,GO:0043025,GO:0043066,GO:0043235,GO:0045509,GO:0045669,GO:0045747,GO:0048711,GO:0048861,GO:0060576,GO:0070062,GO:0070102,GO:0070106,GO:0070110,GO:0070120,GO:0070757" positive regulation of acute inflammatory response|positive regulation of adaptive immune response|cytokine receptor activity|ciliary neurotrophic factor receptor activity|interleukin-6 receptor activity|interleukin-11 receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|ciliary neurotrophic factor receptor binding|interleukin-6 receptor binding|protein binding|extracellular region|plasma membrane|interleukin-6 receptor complex|oncostatin-M receptor complex|glycogen metabolic process|positive regulation of cell population proliferation|external side of plasma membrane|positive regulation of vascular endothelial growth factor production|positive regulation of cardiac muscle hypertrophy|membrane|viral process|cytokine-mediated signaling pathway|growth factor binding|cytokine binding|interleukin-11 binding|interleukin-6 binding|dendrite|response to cytokine|interleukin-11-mediated signaling pathway|oncostatin-M-mediated signaling pathway|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|neuronal cell body|negative regulation of apoptotic process|receptor complex|interleukin-27 receptor activity|positive regulation of osteoblast differentiation|positive regulation of Notch signaling pathway|positive regulation of astrocyte differentiation|leukemia inhibitory factor signaling pathway|intestinal epithelial cell development|extracellular exosome|interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|ciliary neurotrophic factor receptor complex|ciliary neurotrophic factor-mediated signaling pathway|interleukin-35-mediated signaling pathway "hsa04060,hsa04061,hsa04550,hsa04630,hsa04659,hsa05167,hsa05171,hsa05200,hsa05203" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|Th17 cell differentiation|Kaposi sarcoma-associated herpesvirus infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis IL7 73.45613893 71.04691779 75.86536007 1.067820568 0.094669242 0.917883194 1 1.053976493 1.173937934 3574 interleukin 7 "GO:0001961,GO:0002360,GO:0005125,GO:0005139,GO:0005515,GO:0005576,GO:0005615,GO:0006959,GO:0007267,GO:0008083,GO:0008284,GO:0009887,GO:0019221,GO:0030890,GO:0032722,GO:0038111,GO:0043066,GO:0043086,GO:0045453,GO:0045579,GO:0045582,GO:0046622,GO:0048873,GO:0050730,GO:0062023,GO:2001240" positive regulation of cytokine-mediated signaling pathway|T cell lineage commitment|cytokine activity|interleukin-7 receptor binding|protein binding|extracellular region|extracellular space|humoral immune response|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|animal organ morphogenesis|cytokine-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of chemokine production|interleukin-7-mediated signaling pathway|negative regulation of apoptotic process|negative regulation of catalytic activity|bone resorption|positive regulation of B cell differentiation|positive regulation of T cell differentiation|positive regulation of organ growth|homeostasis of number of cells within a tissue|regulation of peptidyl-tyrosine phosphorylation|collagen-containing extracellular matrix|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04060,hsa04151,hsa04630,hsa04640,hsa05200" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer IL7R 1587.205559 2151.706653 1022.704464 0.475299206 -1.073092102 0.001243459 0.10468227 23.77320052 11.78611495 3575 interleukin 7 receptor "GO:0000018,GO:0000902,GO:0001915,GO:0003823,GO:0004896,GO:0004917,GO:0005515,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0006955,GO:0007165,GO:0007166,GO:0008284,GO:0008361,GO:0009897,GO:0010628,GO:0016021,GO:0030217,GO:0030665,GO:0033089,GO:0038111,GO:0042100,GO:0048535,GO:0048872,GO:0050830,GO:0061024,GO:0070233,GO:1904894" regulation of DNA recombination|cell morphogenesis|negative regulation of T cell mediated cytotoxicity|antigen binding|cytokine receptor activity|interleukin-7 receptor activity|protein binding|extracellular region|nucleoplasm|cytosol|plasma membrane|immune response|signal transduction|cell surface receptor signaling pathway|positive regulation of cell population proliferation|regulation of cell size|external side of plasma membrane|positive regulation of gene expression|integral component of membrane|T cell differentiation|clathrin-coated vesicle membrane|positive regulation of T cell differentiation in thymus|interleukin-7-mediated signaling pathway|B cell proliferation|lymph node development|homeostasis of number of cells|defense response to Gram-positive bacterium|membrane organization|negative regulation of T cell apoptotic process|positive regulation of receptor signaling pathway via STAT "hsa04060,hsa04068,hsa04151,hsa04630,hsa04640,hsa05200,hsa05340" Cytokine-cytokine receptor interaction|FoxO signaling pathway|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer|Primary immunodeficiency ILDR1 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.042099868 0.014209572 286676 immunoglobulin like domain containing receptor 1 "GO:0005829,GO:0005886,GO:0006897,GO:0016021,GO:0032991,GO:0042802,GO:0061689,GO:0070506,GO:0090277,GO:1990830" cytosol|plasma membrane|endocytosis|integral component of membrane|protein-containing complex|identical protein binding|tricellular tight junction|high-density lipoprotein particle receptor activity|positive regulation of peptide hormone secretion|cellular response to leukemia inhibitory factor ILF2 4816.596751 4993.583364 4639.610138 0.929114385 -0.106071874 0.74106475 1 135.1723042 131.0004631 3608 interleukin enhancer binding factor 2 "GO:0003677,GO:0003723,GO:0003725,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0016020,GO:0035580,GO:0043312,GO:0045893,GO:1904724,GO:1904813,GO:1990904" "DNA binding|RNA binding|double-stranded RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|nucleolus|membrane|specific granule lumen|neutrophil degranulation|positive regulation of transcription, DNA-templated|tertiary granule lumen|ficolin-1-rich granule lumen|ribonucleoprotein complex" ILF3 8081.792234 7757.308466 8406.276002 1.083658854 0.115910654 0.726210874 1 50.13786469 56.67275788 3609 interleukin enhancer binding factor 3 "GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0006468,GO:0016020,GO:0017148,GO:0035925,GO:0045071,GO:0045892,GO:0045893,GO:0051607,GO:1990904" "DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|protein phosphorylation|membrane|negative regulation of translation|mRNA 3'-UTR AU-rich region binding|negative regulation of viral genome replication|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|defense response to virus|ribonucleoprotein complex" other ILK 5455.289585 5144.811804 5765.767366 1.120695486 0.164394324 0.610425616 1 126.7963835 148.2212321 3611 integrin linked kinase "GO:0000902,GO:0001725,GO:0001934,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005886,GO:0005925,GO:0006468,GO:0007160,GO:0007229,GO:0009967,GO:0016020,GO:0019901,GO:0030017,GO:0030027,GO:0033209,GO:0034329,GO:0034446,GO:0042327,GO:0045893,GO:0070527,GO:0090263,GO:0106310,GO:0106311,GO:1900026,GO:1901224" "cell morphogenesis|stress fiber|positive regulation of protein phosphorylation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|plasma membrane|focal adhesion|protein phosphorylation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of signal transduction|membrane|protein kinase binding|sarcomere|lamellipodium|tumor necrosis factor-mediated signaling pathway|cell junction assembly|substrate adhesion-dependent cell spreading|positive regulation of phosphorylation|positive regulation of transcription, DNA-templated|platelet aggregation|positive regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of NIK/NF-kappaB signaling" "hsa03320,hsa04360,hsa04510,hsa05100,hsa05131,hsa05213" PPAR signaling pathway|Axon guidance|Focal adhesion|Bacterial invasion of epithelial cells|Shigellosis|Endometrial cancer ILKAP 315.6758006 329.8606897 301.4909115 0.913994668 -0.129742346 0.785632721 1 11.69907581 11.15349937 80895 ILK associated serine/threonine phosphatase "GO:0004724,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006470,GO:0046872,GO:0106306,GO:0106307" magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|cytosol|protein dephosphorylation|metal ion binding|protein serine phosphatase activity|protein threonine phosphatase activity ILRUN 1960.104138 1712.230719 2207.977557 1.289532733 0.366848394 0.255810289 1 18.95899552 25.50137656 64771 inflammation and lipid regulator with UBA-like and NBR1-like domains "GO:0000407,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0016236,GO:0016607,GO:0032480,GO:0032720,GO:0043130,GO:0043392,GO:0045087,GO:0050687,GO:1900181" phagophore assembly site|protein binding|nucleus|cytoplasm|centrosome|cytosol|macroautophagy|nuclear speck|negative regulation of type I interferon production|negative regulation of tumor necrosis factor production|ubiquitin binding|negative regulation of DNA binding|innate immune response|negative regulation of defense response to virus|negative regulation of protein localization to nucleus ILVBL 665.3607909 627.2427885 703.4787934 1.121541461 0.165482955 0.666901605 1 11.13091607 13.02153465 10994 ilvB acetolactate synthase like "GO:0000287,GO:0001561,GO:0003674,GO:0003984,GO:0005515,GO:0005789,GO:0005948,GO:0009097,GO:0009099,GO:0016020,GO:0016021,GO:0016829,GO:0030976,GO:0050660" magnesium ion binding|fatty acid alpha-oxidation|molecular_function|acetolactate synthase activity|protein binding|endoplasmic reticulum membrane|acetolactate synthase complex|isoleucine biosynthetic process|valine biosynthetic process|membrane|integral component of membrane|lyase activity|thiamine pyrophosphate binding|flavin adenine dinucleotide binding IMMP1L 112.863994 104.5404647 121.1875232 1.159240334 0.213179697 0.753028484 1 4.057169151 4.905830372 196294 inner mitochondrial membrane peptidase subunit 1 "GO:0003674,GO:0005739,GO:0006627,GO:0008150,GO:0008236,GO:0042720" molecular_function|mitochondrion|protein processing involved in protein targeting to mitochondrion|biological_process|serine-type peptidase activity|mitochondrial inner membrane peptidase complex hsa03060 Protein export IMMP2L 76.78579818 62.92727004 90.64432632 1.440461763 0.526531364 0.48125998 1 0.086124692 0.129403299 83943 inner mitochondrial membrane peptidase subunit 2 "GO:0001541,GO:0004252,GO:0006465,GO:0006627,GO:0006801,GO:0006974,GO:0007283,GO:0007420,GO:0008015,GO:0008233,GO:0016021,GO:0022904,GO:0030728,GO:0033108,GO:0042720,GO:0061300" ovarian follicle development|serine-type endopeptidase activity|signal peptide processing|protein processing involved in protein targeting to mitochondrion|superoxide metabolic process|cellular response to DNA damage stimulus|spermatogenesis|brain development|blood circulation|peptidase activity|integral component of membrane|respiratory electron transport chain|ovulation|mitochondrial respiratory chain complex assembly|mitochondrial inner membrane peptidase complex|cerebellum vasculature development hsa03060 Protein export IMMT 1866.250156 1896.952705 1835.547608 0.967629611 -0.047473176 0.885018999 1 35.36031007 35.68955594 10989 inner membrane mitochondrial protein "GO:0001401,GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0007007,GO:0016020,GO:0042407,GO:0051560,GO:0061617,GO:0140275" SAM complex|RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|inner mitochondrial membrane organization|membrane|cristae formation|mitochondrial calcium ion homeostasis|MICOS complex|MIB complex IMP3 1460.593884 1848.234818 1072.95295 0.58052848 -0.78456125 0.0188067 0.590060224 82.69131923 50.07251217 55272 IMP U3 small nucleolar ribonucleoprotein 3 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0019843,GO:0030515,GO:0030684,GO:0032040,GO:0034457" RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|rRNA processing|rRNA binding|snoRNA binding|preribosome|small-subunit processome|Mpp10 complex hsa03008 Ribosome biogenesis in eukaryotes IMP4 1155.653555 1309.293199 1002.013912 0.765309033 -0.385885668 0.262165945 1 20.38459318 16.27252013 92856 IMP U3 small nucleolar ribonucleoprotein 4 "GO:0001650,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030515,GO:0030684,GO:0032040,GO:0034457" fibrillar center|protein binding|nucleoplasm|nucleolus|rRNA processing|snoRNA binding|preribosome|small-subunit processome|Mpp10 complex hsa03008 Ribosome biogenesis in eukaryotes IMPA1 1095.594488 975.3726856 1215.81629 1.246514597 0.317899777 0.359878775 1 13.8373069 17.99139636 3612 inositol monophosphatase 1 "GO:0000287,GO:0005515,GO:0005737,GO:0005829,GO:0006020,GO:0006021,GO:0006661,GO:0006796,GO:0007165,GO:0008934,GO:0030145,GO:0031403,GO:0042802,GO:0042803,GO:0043647,GO:0046854,GO:0046855,GO:0052832,GO:0052833,GO:0052834" magnesium ion binding|protein binding|cytoplasm|cytosol|inositol metabolic process|inositol biosynthetic process|phosphatidylinositol biosynthetic process|phosphate-containing compound metabolic process|signal transduction|inositol monophosphate 1-phosphatase activity|manganese ion binding|lithium ion binding|identical protein binding|protein homodimerization activity|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity|inositol monophosphate phosphatase activity "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system IMPA2 304.8082005 327.8307778 281.7856231 0.859545968 -0.218353299 0.646183653 1 9.509434351 8.525889931 3613 inositol monophosphatase 2 "GO:0005515,GO:0005737,GO:0005829,GO:0006020,GO:0006021,GO:0006796,GO:0007165,GO:0008934,GO:0042803,GO:0043647,GO:0046854,GO:0046855,GO:0046872,GO:0052832,GO:0052833" protein binding|cytoplasm|cytosol|inositol metabolic process|inositol biosynthetic process|phosphate-containing compound metabolic process|signal transduction|inositol monophosphate 1-phosphatase activity|protein homodimerization activity|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|metal ion binding|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system IMPACT 578.8829305 608.973581 548.79228 0.901175843 -0.150119454 0.70604323 1 7.458854546 7.011284809 55364 impact RWD domain protein "GO:0000122,GO:0001933,GO:0003674,GO:0003779,GO:0005515,GO:0005575,GO:0005737,GO:0005844,GO:0006446,GO:0006469,GO:0008150,GO:0031333,GO:0031953,GO:0034198,GO:0042149,GO:0045666,GO:0060548,GO:0070301,GO:0071264,GO:0071468,GO:0071494,GO:0072755,GO:0097201,GO:0140469,GO:1990138,GO:1990253" negative regulation of transcription by RNA polymerase II|negative regulation of protein phosphorylation|molecular_function|actin binding|protein binding|cellular_component|cytoplasm|polysome|regulation of translational initiation|negative regulation of protein kinase activity|biological_process|negative regulation of protein-containing complex assembly|negative regulation of protein autophosphorylation|cellular response to amino acid starvation|cellular response to glucose starvation|positive regulation of neuron differentiation|negative regulation of cell death|cellular response to hydrogen peroxide|positive regulation of translational initiation in response to starvation|cellular response to acidic pH|cellular response to UV-C|cellular response to benomyl|negative regulation of transcription from RNA polymerase II promoter in response to stress|GCN2-mediated signaling|neuron projection extension|cellular response to leucine starvation IMPDH1 1914.347242 1918.26678 1910.427704 0.995913459 -0.005907712 0.987240202 1 36.57885737 37.99860615 3614 inosine monophosphate dehydrogenase 1 "GO:0000166,GO:0003676,GO:0003677,GO:0003723,GO:0003938,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006177,GO:0006183,GO:0009168,GO:0034774,GO:0035578,GO:0043312,GO:0046872,GO:0055114,GO:1904813" nucleotide binding|nucleic acid binding|DNA binding|RNA binding|IMP dehydrogenase activity|extracellular region|nucleus|cytoplasm|cytosol|GMP biosynthetic process|GTP biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|secretory granule lumen|azurophil granule lumen|neutrophil degranulation|metal ion binding|oxidation-reduction process|ficolin-1-rich granule lumen "hsa00230,hsa00983" Purine metabolism|Drug metabolism - other enzymes IMPDH2 6908.459097 6687.544876 7129.373318 1.066067361 0.0922986 0.778145435 1 196.5760625 218.5904623 3615 inosine monophosphate dehydrogenase 2 "GO:0000166,GO:0003677,GO:0003723,GO:0003938,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005778,GO:0005829,GO:0006177,GO:0006183,GO:0007623,GO:0009168,GO:0016020,GO:0034774,GO:0043312,GO:0046872,GO:0055114,GO:0070062,GO:1904813" nucleotide binding|DNA binding|RNA binding|IMP dehydrogenase activity|protein binding|extracellular region|nucleus|cytoplasm|peroxisomal membrane|cytosol|GMP biosynthetic process|GTP biosynthetic process|circadian rhythm|purine ribonucleoside monophosphate biosynthetic process|membrane|secretory granule lumen|neutrophil degranulation|metal ion binding|oxidation-reduction process|extracellular exosome|ficolin-1-rich granule lumen "hsa00230,hsa00983" Purine metabolism|Drug metabolism - other enzymes IMPG2 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.012309372 0.024928 50939 interphotoreceptor matrix proteoglycan 2 "GO:0005201,GO:0005540,GO:0007601,GO:0008201,GO:0016021,GO:0031012,GO:0033165,GO:0042995,GO:0043235" extracellular matrix structural constituent|hyaluronic acid binding|visual perception|heparin binding|integral component of membrane|extracellular matrix|interphotoreceptor matrix|cell projection|receptor complex INAFM1 70.09950973 43.64310664 96.55591282 2.212397793 1.145610808 0.134773407 1 2.634528472 6.079698502 255783 InaF motif containing 1 "GO:0005246,GO:0016021" calcium channel regulator activity|integral component of membrane INAFM2 260.7264015 311.5914823 209.8613207 0.673514305 -0.570219506 0.249266964 1 5.179195717 3.638522602 100505573 InaF motif containing 2 "GO:0005246,GO:0016021" calcium channel regulator activity|integral component of membrane INAVA 3381.647703 3719.813624 3043.481783 0.818181256 -0.289507609 0.362839443 1 33.75657361 28.80871012 55765 innate immunity activator "GO:0000187,GO:0002221,GO:0002367,GO:0005515,GO:0005634,GO:0005737,GO:0031398,GO:0032494,GO:0032495,GO:0032731,GO:0032733,GO:0032755,GO:0032874,GO:0034334,GO:0043123,GO:0045087,GO:0060729,GO:0070431,GO:1903409" activation of MAPK activity|pattern recognition receptor signaling pathway|cytokine production involved in immune response|protein binding|nucleus|cytoplasm|positive regulation of protein ubiquitination|response to peptidoglycan|response to muramyl dipeptide|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-6 production|positive regulation of stress-activated MAPK cascade|adherens junction maintenance|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|intestinal epithelial structure maintenance|nucleotide-binding oligomerization domain containing 2 signaling pathway|reactive oxygen species biosynthetic process INCA1 16.04630041 19.2841634 12.80843742 0.664194611 -0.590322077 0.648095474 1 0.431203022 0.298739792 388324 "inhibitor of CDK, cyclin A1 interacting protein 1" "GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008285,GO:0016604,GO:0030332,GO:0042802,GO:0044877,GO:0045736,GO:2001235" cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|negative regulation of cell population proliferation|nuclear body|cyclin binding|identical protein binding|protein-containing complex binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of apoptotic signaling pathway INCENP 3119.845971 2863.190787 3376.501156 1.179279135 0.237905245 0.454641128 1 22.38853059 27.53963216 3619 inner centromere protein "GO:0000070,GO:0000281,GO:0000775,GO:0000776,GO:0000777,GO:0000793,GO:0000800,GO:0000801,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0005819,GO:0005829,GO:0005874,GO:0007059,GO:0010032,GO:0010369,GO:0016572,GO:0016604,GO:0030496,GO:0032133,GO:0032991,GO:0043539,GO:0051257,GO:0051310,GO:0071902,GO:1902412,GO:1990385" "mitotic sister chromatid segregation|mitotic cytokinesis|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed chromosome|lateral element|central element|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|spindle|cytosol|microtubule|chromosome segregation|meiotic chromosome condensation|chromocenter|histone phosphorylation|nuclear body|midbody|chromosome passenger complex|protein-containing complex|protein serine/threonine kinase activator activity|meiotic spindle midzone assembly|metaphase plate congression|positive regulation of protein serine/threonine kinase activity|regulation of mitotic cytokinesis|meiotic spindle midzone" INF2 2144.577952 1828.950655 2460.205248 1.345145776 0.427762529 0.18272799 1 10.91947407 15.32099614 64423 inverted formin 2 "GO:0003779,GO:0030036,GO:0048471,GO:0090140" actin binding|actin cytoskeleton organization|perinuclear region of cytoplasm|regulation of mitochondrial fission ING1 310.2447221 295.3521868 325.1372575 1.100845946 0.13861259 0.772188179 1 3.639548983 4.179170079 3621 inhibitor of growth family member 1 "GO:0005515,GO:0005634,GO:0007049,GO:0008285,GO:0010941,GO:0030308,GO:0035064,GO:0045893,GO:0046872" "protein binding|nucleus|cell cycle|negative regulation of cell population proliferation|regulation of cell death|negative regulation of cell growth|methylated histone binding|positive regulation of transcription, DNA-templated|metal ion binding" ING2 195.9325231 192.841634 199.0234121 1.032056242 0.045521593 0.943059374 1 6.442446212 6.935377354 3622 inhibitor of growth family member 2 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006325,GO:0006355,GO:0007141,GO:0007165,GO:0007283,GO:0007286,GO:0008285,GO:0016580,GO:0016602,GO:0030317,GO:0030511,GO:0031065,GO:0035064,GO:0035091,GO:0040008,GO:0044877,GO:0045893,GO:0046872,GO:0048133,GO:0072520,GO:1902166,GO:2000772,GO:2001020" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|plasma membrane|chromatin organization|regulation of transcription, DNA-templated|male meiosis I|signal transduction|spermatogenesis|spermatid development|negative regulation of cell population proliferation|Sin3 complex|CCAAT-binding factor complex|flagellated sperm motility|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of histone deacetylation|methylated histone binding|phosphatidylinositol binding|regulation of growth|protein-containing complex binding|positive regulation of transcription, DNA-templated|metal ion binding|male germ-line stem cell asymmetric division|seminiferous tubule development|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of cellular senescence|regulation of response to DNA damage stimulus" ING3 221.3388354 212.1257974 230.5518735 1.08686391 0.120171306 0.825064729 1 2.336542693 2.648895456 54556 inhibitor of growth family member 3 "GO:0000812,GO:0005654,GO:0032777,GO:0035064,GO:0035267,GO:0040008,GO:0043065,GO:0043967,GO:0043968,GO:0046872" Swr1 complex|nucleoplasm|Piccolo NuA4 histone acetyltransferase complex|methylated histone binding|NuA4 histone acetyltransferase complex|regulation of growth|positive regulation of apoptotic process|histone H4 acetylation|histone H2A acetylation|metal ion binding ING4 307.9178947 270.9932436 344.8425458 1.272513444 0.347680899 0.460150659 1 7.020384542 9.318354116 51147 inhibitor of growth family member 4 "GO:0000123,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006473,GO:0006915,GO:0006978,GO:0007050,GO:0008285,GO:0035064,GO:0043065,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0045111,GO:0045892,GO:0045893,GO:0045926,GO:0046872,GO:0070776" "histone acetyltransferase complex|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytosol|DNA replication|protein acetylation|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|cell cycle arrest|negative regulation of cell population proliferation|methylated histone binding|positive regulation of apoptotic process|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|intermediate filament cytoskeleton|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of growth|metal ion binding|MOZ/MORF histone acetyltransferase complex" ING5 659.8406378 586.6445497 733.0367259 1.249541526 0.321398847 0.401475717 1 2.797427444 3.646073797 84289 inhibitor of growth family member 5 "GO:0000123,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006260,GO:0006473,GO:0008285,GO:0035064,GO:0043065,GO:0043966,GO:0043967,GO:0044154,GO:0045893,GO:0045926,GO:0046872,GO:0070776,GO:1901796,GO:2001235" "histone acetyltransferase complex|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|DNA replication|protein acetylation|negative regulation of cell population proliferation|methylated histone binding|positive regulation of apoptotic process|histone H3 acetylation|histone H4 acetylation|histone H3-K14 acetylation|positive regulation of transcription, DNA-templated|negative regulation of growth|metal ion binding|MOZ/MORF histone acetyltransferase complex|regulation of signal transduction by p53 class mediator|positive regulation of apoptotic signaling pathway" INHA 10.04563925 13.19442759 6.896850916 0.522709369 -0.935919077 0.529573094 1 0.494634501 0.269687377 3623 inhibin subunit alpha "GO:0001501,GO:0001541,GO:0001750,GO:0001917,GO:0005102,GO:0005125,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0007050,GO:0007165,GO:0007166,GO:0007267,GO:0008083,GO:0008584,GO:0010862,GO:0030154,GO:0030218,GO:0032689,GO:0034673,GO:0034711,GO:0042127,GO:0042326,GO:0042541,GO:0043025,GO:0043512,GO:0043513,GO:0044877,GO:0045578,GO:0045650,GO:0045786,GO:0046881,GO:0046882,GO:0051726,GO:0060395" skeletal system development|ovarian follicle development|photoreceptor outer segment|photoreceptor inner segment|signaling receptor binding|cytokine activity|hormone activity|protein binding|extracellular region|extracellular space|cytoplasm|cell cycle arrest|signal transduction|cell surface receptor signaling pathway|cell-cell signaling|growth factor activity|male gonad development|positive regulation of pathway-restricted SMAD protein phosphorylation|cell differentiation|erythrocyte differentiation|negative regulation of interferon-gamma production|inhibin-betaglycan-ActRII complex|inhibin binding|regulation of cell population proliferation|negative regulation of phosphorylation|hemoglobin biosynthetic process|neuronal cell body|inhibin A complex|inhibin B complex|protein-containing complex binding|negative regulation of B cell differentiation|negative regulation of macrophage differentiation|negative regulation of cell cycle|positive regulation of follicle-stimulating hormone secretion|negative regulation of follicle-stimulating hormone secretion|regulation of cell cycle|SMAD protein signal transduction hsa04060 Cytokine-cytokine receptor interaction INHBA 13985.77798 16971.07875 11000.47721 0.648189627 -0.625512161 0.072901329 1 105.9703203 71.64770007 3624 inhibin subunit beta A "GO:0000082,GO:0001541,GO:0001942,GO:0002244,GO:0005125,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0006357,GO:0006952,GO:0007050,GO:0007166,GO:0007267,GO:0007399,GO:0008083,GO:0008285,GO:0008584,GO:0009611,GO:0010628,GO:0010862,GO:0017046,GO:0021773,GO:0030154,GO:0030218,GO:0030308,GO:0032270,GO:0032689,GO:0032924,GO:0034711,GO:0035987,GO:0042326,GO:0042476,GO:0042493,GO:0042541,GO:0042701,GO:0042802,GO:0043509,GO:0043512,GO:0044877,GO:0045578,GO:0045648,GO:0045650,GO:0045786,GO:0045893,GO:0045944,GO:0046880,GO:0046881,GO:0046882,GO:0048333,GO:0048471,GO:0060021,GO:0060279,GO:0060395,GO:0061029,GO:0070699,GO:0071372,GO:0071397,GO:0097154,GO:0097191,GO:2001241" "G1/S transition of mitotic cell cycle|ovarian follicle development|hair follicle development|hematopoietic progenitor cell differentiation|cytokine activity|hormone activity|protein binding|extracellular region|extracellular space|regulation of transcription by RNA polymerase II|defense response|cell cycle arrest|cell surface receptor signaling pathway|cell-cell signaling|nervous system development|growth factor activity|negative regulation of cell population proliferation|male gonad development|response to wounding|positive regulation of gene expression|positive regulation of pathway-restricted SMAD protein phosphorylation|peptide hormone binding|striatal medium spiny neuron differentiation|cell differentiation|erythrocyte differentiation|negative regulation of cell growth|positive regulation of cellular protein metabolic process|negative regulation of interferon-gamma production|activin receptor signaling pathway|inhibin binding|endodermal cell differentiation|negative regulation of phosphorylation|odontogenesis|response to drug|hemoglobin biosynthetic process|progesterone secretion|identical protein binding|activin A complex|inhibin A complex|protein-containing complex binding|negative regulation of B cell differentiation|positive regulation of erythrocyte differentiation|negative regulation of macrophage differentiation|negative regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of follicle-stimulating hormone secretion|positive regulation of follicle-stimulating hormone secretion|negative regulation of follicle-stimulating hormone secretion|mesodermal cell differentiation|perinuclear region of cytoplasm|roof of mouth development|positive regulation of ovulation|SMAD protein signal transduction|eyelid development in camera-type eye|type II activin receptor binding|cellular response to follicle-stimulating hormone stimulus|cellular response to cholesterol|GABAergic neuron differentiation|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells INHBB 28.01793116 29.43372308 26.60213925 0.903797973 -0.145927774 0.920544463 1 0.464976369 0.438347137 3625 inhibin subunit beta B "GO:0001541,GO:0005125,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0006952,GO:0008083,GO:0009267,GO:0009611,GO:0010862,GO:0030154,GO:0032686,GO:0032869,GO:0032924,GO:0042803,GO:0044320,GO:0044650,GO:0045444,GO:0046676,GO:0046789,GO:0046881,GO:0046882,GO:0048471,GO:0048599,GO:0060279,GO:0060395,GO:0071944,GO:2001235" ovarian follicle development|cytokine activity|hormone activity|protein binding|extracellular region|extracellular space|defense response|growth factor activity|cellular response to starvation|response to wounding|positive regulation of pathway-restricted SMAD protein phosphorylation|cell differentiation|negative regulation of hepatocyte growth factor production|cellular response to insulin stimulus|activin receptor signaling pathway|protein homodimerization activity|cellular response to leptin stimulus|adhesion of symbiont to host cell|fat cell differentiation|negative regulation of insulin secretion|host cell surface receptor binding|positive regulation of follicle-stimulating hormone secretion|negative regulation of follicle-stimulating hormone secretion|perinuclear region of cytoplasm|oocyte development|positive regulation of ovulation|SMAD protein signal transduction|cell periphery|positive regulation of apoptotic signaling pathway "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells INHBC 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.080268487 0.01625536 3626 inhibin subunit beta C "GO:0005125,GO:0005160,GO:0005179,GO:0005576,GO:0005615,GO:0008083,GO:0010862,GO:0060395" cytokine activity|transforming growth factor beta receptor binding|hormone activity|extracellular region|extracellular space|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells INIP 483.1165654 629.2727004 336.9604305 0.535476003 -0.901106172 0.029468772 0.763169617 7.324854593 4.091239942 58493 INTS3 and NABP interacting protein "GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006974,GO:0010212,GO:0035861,GO:0070876" protein binding|nucleus|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|response to ionizing radiation|site of double-strand break|SOSS complex INKA1 41.97493653 40.59823873 43.35163433 1.067820568 0.094669242 0.943772922 1 2.157563032 2.403132427 389119 inka box actin regulator 1 "GO:0005515,GO:0005634,GO:0005737,GO:0019901,GO:0030291,GO:0071901" protein binding|nucleus|cytoplasm|protein kinase binding|protein serine/threonine kinase inhibitor activity|negative regulation of protein serine/threonine kinase activity INKA2 52.81284511 40.59823873 65.02745149 1.601730851 0.679631743 0.419628564 1 0.333088866 0.556500535 55924 inka box actin regulator 2 "GO:0005634,GO:0005654,GO:0019901,GO:0030291,GO:0071901" nucleus|nucleoplasm|protein kinase binding|protein serine/threonine kinase inhibitor activity|negative regulation of protein serine/threonine kinase activity INO80 1013.068325 1193.588219 832.548432 0.6975173 -0.519699095 0.139623454 1 7.484342275 5.445334386 54617 INO80 complex ATPase subunit "GO:0000070,GO:0000724,GO:0003677,GO:0003779,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005874,GO:0006281,GO:0006302,GO:0006338,GO:0006351,GO:0008094,GO:0010571,GO:0016579,GO:0016604,GO:0016887,GO:0030307,GO:0031011,GO:0032508,GO:0034644,GO:0042393,GO:0042766,GO:0043014,GO:0043044,GO:0043138,GO:0043618,GO:0045944,GO:0051225,GO:0051301,GO:0070914,GO:0071479,GO:2000045" "mitotic sister chromatid segregation|double-strand break repair via homologous recombination|DNA binding|actin binding|protein binding|ATP binding|nucleus|nucleoplasm|spindle|cytosol|microtubule|DNA repair|double-strand break repair|chromatin remodeling|transcription, DNA-templated|DNA-dependent ATPase activity|positive regulation of nuclear cell cycle DNA replication|protein deubiquitination|nuclear body|ATPase activity|positive regulation of cell growth|Ino80 complex|DNA duplex unwinding|cellular response to UV|histone binding|nucleosome mobilization|alpha-tubulin binding|ATP-dependent chromatin remodeling|3'-5' DNA helicase activity|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription by RNA polymerase II|spindle assembly|cell division|UV-damage excision repair|cellular response to ionizing radiation|regulation of G1/S transition of mitotic cell cycle" chromosome_remodelling_factor INO80B 356.8463436 349.1448531 364.5478341 1.044116305 0.062282425 0.895571843 1 14.9728663 16.30683791 83444 INO80 complex subunit B "GO:0005515,GO:0005654,GO:0005730,GO:0006281,GO:0006310,GO:0016579,GO:0031011,GO:0043044,GO:0046872" protein binding|nucleoplasm|nucleolus|DNA repair|DNA recombination|protein deubiquitination|Ino80 complex|ATP-dependent chromatin remodeling|metal ion binding INO80C 170.464106 202.9911937 137.9370183 0.679522179 -0.557407454 0.327329625 1 5.064427512 3.58963198 125476 INO80 complex subunit C "GO:0003674,GO:0005515,GO:0005654,GO:0006281,GO:0006310,GO:0006338,GO:0008150,GO:0016579,GO:0031011,GO:0071339" molecular_function|protein binding|nucleoplasm|DNA repair|DNA recombination|chromatin remodeling|biological_process|protein deubiquitination|Ino80 complex|MLL1 complex INO80D 547.6447037 527.7771036 567.5123039 1.075287844 0.104722907 0.796806457 1 1.639377394 1.83873697 54891 INO80 complex subunit D "GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0016579" nucleus|nucleoplasm|DNA repair|DNA recombination|protein deubiquitination INO80E 793.7514832 715.5439577 871.9590086 1.218596006 0.285219916 0.438858166 1 10.40177301 13.22157072 283899 INO80 complex subunit E "GO:0005515,GO:0005654,GO:0005730,GO:0006281,GO:0006310,GO:0006338,GO:0016579,GO:0031011" protein binding|nucleoplasm|nucleolus|DNA repair|DNA recombination|chromatin remodeling|protein deubiquitination|Ino80 complex INPP1 299.2907689 253.7389921 344.8425458 1.359044359 0.442592546 0.350489516 1 5.422356461 7.686659197 3628 inositol polyphosphate-1-phosphatase "GO:0004441,GO:0005515,GO:0005829,GO:0006796,GO:0007165,GO:0043647,GO:0046854,GO:0046855,GO:0046872" "inositol-1,4-bisphosphate 1-phosphatase activity|protein binding|cytosol|phosphate-containing compound metabolic process|signal transduction|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|metal ion binding" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP4A 861.6374885 809.9348628 913.3401141 1.127671071 0.173346311 0.633605025 1 2.248922342 2.645287185 3631 inositol polyphosphate-4-phosphatase type I A "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0007165,GO:0014069,GO:0016311,GO:0016316,GO:0031901,GO:0031965,GO:0034597,GO:0036092,GO:0043647,GO:0055038" "protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|signal transduction|postsynaptic density|dephosphorylation|phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|early endosome membrane|nuclear membrane|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|phosphatidylinositol-3-phosphate biosynthetic process|inositol phosphate metabolic process|recycling endosome membrane" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP4B 176.6874538 224.305269 129.0696386 0.575419557 -0.797313839 0.156058071 1 0.88613655 0.531864738 8821 inositol polyphosphate-4-phosphatase type II B "GO:0005515,GO:0005737,GO:0005829,GO:0006661,GO:0007165,GO:0016311,GO:0016316,GO:0034597,GO:0036092,GO:0043647" "protein binding|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|signal transduction|dephosphorylation|phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|phosphatidylinositol-3-phosphate biosynthetic process|inositol phosphate metabolic process" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5A 286.5565604 258.8137719 314.2993489 1.214384175 0.280224896 0.561957037 1 1.908006479 2.416862114 3632 inositol polyphosphate-5-phosphatase A "GO:0004445,GO:0005515,GO:0005886,GO:0016020,GO:0030425,GO:0042731,GO:0043647,GO:0046855,GO:0046856,GO:0048016,GO:0052658,GO:0052659,GO:1901215" "inositol-polyphosphate 5-phosphatase activity|protein binding|plasma membrane|membrane|dendrite|PH domain binding|inositol phosphate metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|inositol phosphate-mediated signaling|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|negative regulation of neuron death" "hsa00562,hsa04070,hsa04910" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Insulin signaling pathway INPP5B 366.6423263 311.5914823 421.6931703 1.353352689 0.43653786 0.326903504 1 2.992795249 4.224778317 3633 inositol polyphosphate-5-phosphatase B "GO:0001701,GO:0004439,GO:0005515,GO:0005793,GO:0005794,GO:0005829,GO:0005886,GO:0007165,GO:0007283,GO:0016020,GO:0016021,GO:0030317,GO:0030670,GO:0031901,GO:0043647,GO:0046855,GO:0046856,GO:0046872,GO:0051056,GO:0052658,GO:0070613" "in utero embryonic development|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|plasma membrane|signal transduction|spermatogenesis|membrane|integral component of membrane|flagellated sperm motility|phagocytic vesicle membrane|early endosome membrane|inositol phosphate metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|metal ion binding|regulation of small GTPase mediated signal transduction|inositol-1,4,5-trisphosphate 5-phosphatase activity|regulation of protein processing" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5E 585.4019561 482.104085 688.6998272 1.428529333 0.514530661 0.190930859 1 7.145704168 10.64756071 56623 inositol polyphosphate-5-phosphatase E "GO:0001726,GO:0004439,GO:0004445,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0005929,GO:0005930,GO:0006661,GO:0008150,GO:0014067,GO:0016314,GO:0017148,GO:0032580,GO:0046855,GO:0046856,GO:1903565" "ruffle|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|nucleus|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|focal adhesion|cilium|axoneme|phosphatidylinositol biosynthetic process|biological_process|negative regulation of phosphatidylinositol 3-kinase signaling|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|negative regulation of translation|Golgi cisterna membrane|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|negative regulation of protein localization to cilium" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5F 358.4011907 320.726086 396.0762955 1.23493633 0.304436662 0.498315341 1 2.33050858 3.00200356 22876 inositol polyphosphate-5-phosphatase F "GO:0001921,GO:0005515,GO:0005769,GO:0005905,GO:0006661,GO:0008344,GO:0008934,GO:0014898,GO:0030424,GO:0030425,GO:0031161,GO:0031901,GO:0033137,GO:0034595,GO:0034596,GO:0042532,GO:0042803,GO:0043025,GO:0043231,GO:0043812,GO:0045334,GO:0046856,GO:0048015,GO:0048681,GO:0051896,GO:0052832,GO:0052833,GO:0055037,GO:0072583,GO:2000145,GO:2001135" positive regulation of receptor recycling|protein binding|early endosome|clathrin-coated pit|phosphatidylinositol biosynthetic process|adult locomotory behavior|inositol monophosphate 1-phosphatase activity|cardiac muscle hypertrophy in response to stress|axon|dendrite|phosphatidylinositol catabolic process|early endosome membrane|negative regulation of peptidyl-serine phosphorylation|phosphatidylinositol phosphate 5-phosphatase activity|phosphatidylinositol phosphate 4-phosphatase activity|negative regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|neuronal cell body|intracellular membrane-bounded organelle|phosphatidylinositol-4-phosphate phosphatase activity|clathrin-coated endocytic vesicle|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|negative regulation of axon regeneration|regulation of protein kinase B signaling|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity|recycling endosome|clathrin-dependent endocytosis|regulation of cell motility|regulation of endocytic recycling "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5J 158.0795151 130.9293199 185.2297103 1.414730562 0.500527315 0.391750784 1 1.503311758 2.218394191 27124 inositol polyphosphate-5-phosphatase J "GO:0001726,GO:0004439,GO:0004445,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0010977,GO:0017124,GO:0019898,GO:0030426,GO:0031115,GO:0033137,GO:0034485,GO:0043198,GO:0043647,GO:0046855,GO:0046856,GO:0052658,GO:0052659" "ruffle|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|protein binding|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|negative regulation of neuron projection development|SH3 domain binding|extrinsic component of membrane|growth cone|negative regulation of microtubule polymerization|negative regulation of peptidyl-serine phosphorylation|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|dendritic shaft|inositol phosphate metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity" hsa00562 Inositol phosphate metabolism INPP5K 687.3132346 713.5140458 661.1124235 0.926558387 -0.110046204 0.774461297 1 11.6270815 11.23723435 51763 inositol polyphosphate-5-phosphatase K "GO:0001701,GO:0001726,GO:0001933,GO:0004439,GO:0004445,GO:0005000,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005802,GO:0005829,GO:0005886,GO:0005979,GO:0006469,GO:0006661,GO:0007186,GO:0010801,GO:0010829,GO:0016020,GO:0016311,GO:0016312,GO:0030036,GO:0032587,GO:0032869,GO:0032870,GO:0033137,GO:0034485,GO:0034594,GO:0034595,GO:0035305,GO:0035810,GO:0042577,GO:0042593,GO:0043005,GO:0043407,GO:0043922,GO:0045719,GO:0045869,GO:0045892,GO:0045893,GO:0046030,GO:0046627,GO:0046855,GO:0046856,GO:0048471,GO:0051497,GO:0051898,GO:0051926,GO:0052658,GO:0052659,GO:0071320,GO:0071356,GO:0071364,GO:0072659,GO:0090315,GO:0097178,GO:2000466,GO:2001153" "in utero embryonic development|ruffle|negative regulation of protein phosphorylation|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|vasopressin receptor activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|trans-Golgi network|cytosol|plasma membrane|regulation of glycogen biosynthetic process|negative regulation of protein kinase activity|phosphatidylinositol biosynthetic process|G protein-coupled receptor signaling pathway|negative regulation of peptidyl-threonine phosphorylation|negative regulation of glucose transmembrane transport|membrane|dephosphorylation|inositol bisphosphate phosphatase activity|actin cytoskeleton organization|ruffle membrane|cellular response to insulin stimulus|cellular response to hormone stimulus|negative regulation of peptidyl-serine phosphorylation|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|phosphatidylinositol trisphosphate phosphatase activity|phosphatidylinositol phosphate 5-phosphatase activity|negative regulation of dephosphorylation|positive regulation of urine volume|lipid phosphatase activity|glucose homeostasis|neuron projection|negative regulation of MAP kinase activity|negative regulation by host of viral transcription|negative regulation of glycogen biosynthetic process|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|inositol trisphosphate phosphatase activity|negative regulation of insulin receptor signaling pathway|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|negative regulation of stress fiber assembly|negative regulation of protein kinase B signaling|negative regulation of calcium ion transport|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|cellular response to cAMP|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|protein localization to plasma membrane|negative regulation of protein targeting to membrane|ruffle assembly|negative regulation of glycogen (starch) synthase activity|positive regulation of renal water transport" hsa00562 Inositol phosphate metabolism INPPL1 4793.656813 4199.887797 5387.42583 1.282754704 0.359245316 0.262613216 1 40.36233408 54.00522982 3636 inositol polyphosphate phosphatase like 1 "GO:0001958,GO:0002376,GO:0003779,GO:0005515,GO:0005634,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0006006,GO:0006661,GO:0006897,GO:0007015,GO:0007155,GO:0008285,GO:0009791,GO:0010629,GO:0016607,GO:0016787,GO:0017124,GO:0019221,GO:0030027,GO:0030175,GO:0032868,GO:0042169,GO:0043647,GO:0046856,GO:0097178" endochondral ossification|immune system process|actin binding|protein binding|nucleus|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|glucose metabolic process|phosphatidylinositol biosynthetic process|endocytosis|actin filament organization|cell adhesion|negative regulation of cell population proliferation|post-embryonic development|negative regulation of gene expression|nuclear speck|hydrolase activity|SH3 domain binding|cytokine-mediated signaling pathway|lamellipodium|filopodium|response to insulin|SH2 domain binding|inositol phosphate metabolic process|phosphatidylinositol dephosphorylation|ruffle assembly "hsa00562,hsa04070,hsa04662,hsa04666,hsa04910" Inositol phosphate metabolism|Phosphatidylinositol signaling system|B cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Insulin signaling pathway INSIG1 317.802952 239.5296085 396.0762955 1.653558814 0.725574361 0.118785468 1 4.581317848 7.9017994 3638 insulin induced gene 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006641,GO:0006695,GO:0008142,GO:0010894,GO:0016126,GO:0032869,GO:0032933,GO:0032937,GO:0036315,GO:0036316,GO:0042472,GO:0042474,GO:0042632,GO:0045599,GO:0045717,GO:0060021,GO:0060363,GO:0070862,GO:1901303" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|triglyceride metabolic process|cholesterol biosynthetic process|oxysterol binding|negative regulation of steroid biosynthetic process|sterol biosynthetic process|cellular response to insulin stimulus|SREBP signaling pathway|SREBP-SCAP-Insig complex|cellular response to sterol|SREBP-SCAP complex retention in endoplasmic reticulum|inner ear morphogenesis|middle ear morphogenesis|cholesterol homeostasis|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|roof of mouth development|cranial suture morphogenesis|negative regulation of protein exit from endoplasmic reticulum|negative regulation of cargo loading into COPII-coated vesicle INSIG2 287.1422266 399.8926515 174.3918017 0.43609654 -1.197280551 0.013339828 0.515122602 6.128033907 2.787531158 51141 insulin induced gene 2 "GO:0005515,GO:0005783,GO:0005789,GO:0006695,GO:0008142,GO:0016126,GO:0032869,GO:0032933,GO:0032937,GO:0036316" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|oxysterol binding|sterol biosynthetic process|cellular response to insulin stimulus|SREBP signaling pathway|SREBP-SCAP-Insig complex|SREBP-SCAP complex retention in endoplasmic reticulum INSM2 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.071122711 0.054012103 84684 INSM transcriptional repressor 2 "GO:0000122,GO:0000978,GO:0001227,GO:0005634,GO:0005737,GO:0010564,GO:0017053,GO:0030182,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|cytoplasm|regulation of cell cycle process|transcription repressor complex|neuron differentiation|metal ion binding" INSR 578.4363195 410.0422112 746.8304277 1.821350113 0.865008274 0.02891174 0.757968522 2.1927137 4.165731717 3643 insulin receptor "GO:0000187,GO:0001540,GO:0001934,GO:0002092,GO:0003007,GO:0004713,GO:0004714,GO:0005009,GO:0005159,GO:0005515,GO:0005524,GO:0005525,GO:0005635,GO:0005764,GO:0005770,GO:0005886,GO:0005887,GO:0005899,GO:0005901,GO:0005975,GO:0006355,GO:0006468,GO:0006898,GO:0007169,GO:0007186,GO:0007275,GO:0007612,GO:0007613,GO:0008284,GO:0008286,GO:0009897,GO:0010008,GO:0014068,GO:0016020,GO:0018108,GO:0019087,GO:0019904,GO:0030335,GO:0030424,GO:0031981,GO:0031994,GO:0031995,GO:0032147,GO:0032148,GO:0032590,GO:0032809,GO:0032869,GO:0033674,GO:0038024,GO:0042593,GO:0043235,GO:0043243,GO:0043410,GO:0043548,GO:0043559,GO:0043560,GO:0044877,GO:0045429,GO:0045725,GO:0045821,GO:0045840,GO:0045995,GO:0046326,GO:0046777,GO:0048639,GO:0051425,GO:0051897,GO:0060267,GO:0070062,GO:0097062,GO:0097242,GO:0150104,GO:1990535" "activation of MAPK activity|amyloid-beta binding|positive regulation of protein phosphorylation|positive regulation of receptor internalization|heart morphogenesis|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|insulin-activated receptor activity|insulin-like growth factor receptor binding|protein binding|ATP binding|GTP binding|nuclear envelope|lysosome|late endosome|plasma membrane|integral component of plasma membrane|insulin receptor complex|caveola|carbohydrate metabolic process|regulation of transcription, DNA-templated|protein phosphorylation|receptor-mediated endocytosis|transmembrane receptor protein tyrosine kinase signaling pathway|G protein-coupled receptor signaling pathway|multicellular organism development|learning|memory|positive regulation of cell population proliferation|insulin receptor signaling pathway|external side of plasma membrane|endosome membrane|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|peptidyl-tyrosine phosphorylation|transformation of host cell by virus|protein domain specific binding|positive regulation of cell migration|axon|nuclear lumen|insulin-like growth factor I binding|insulin-like growth factor II binding|activation of protein kinase activity|activation of protein kinase B activity|dendrite membrane|neuronal cell body membrane|cellular response to insulin stimulus|positive regulation of kinase activity|cargo receptor activity|glucose homeostasis|receptor complex|positive regulation of protein-containing complex disassembly|positive regulation of MAPK cascade|phosphatidylinositol 3-kinase binding|insulin binding|insulin receptor substrate binding|protein-containing complex binding|positive regulation of nitric oxide biosynthetic process|positive regulation of glycogen biosynthetic process|positive regulation of glycolytic process|positive regulation of mitotic nuclear division|regulation of embryonic development|positive regulation of glucose import|protein autophosphorylation|positive regulation of developmental growth|PTB domain binding|positive regulation of protein kinase B signaling|positive regulation of respiratory burst|extracellular exosome|dendritic spine maintenance|amyloid-beta clearance|transport across blood-brain barrier|neuron projection maintenance" "hsa04010,hsa04014,hsa04015,hsa04022,hsa04066,hsa04068,hsa04072,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04520,hsa04910,hsa04913,hsa04923,hsa04930,hsa04931,hsa04932,hsa04960,hsa05010" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adherens junction|Insulin signaling pathway|Ovarian steroidogenesis|Regulation of lipolysis in adipocytes|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|Aldosterone-regulated sodium reabsorption|Alzheimer disease INSYN1 4.956013635 2.029911937 7.882115332 3.882983882 1.957165719 0.335178207 1 0.014002708 0.056714425 388135 inhibitory synaptic factor 1 "GO:0005515,GO:0014069,GO:0060080" protein binding|postsynaptic density|inhibitory postsynaptic potential INSYN2B 83.20486266 63.94222601 102.4674993 1.602501285 0.680325513 0.347127656 1 0.555003971 0.927706088 100131897 inhibitory synaptic factor family member 2B INTS1 4344.243865 4359.235884 4329.251846 0.993121722 -0.009957543 0.975915847 1 30.67239776 31.7735791 26173 integrator complex subunit 1 "GO:0005654,GO:0016020,GO:0016021,GO:0016180,GO:0031965,GO:0032039,GO:0034474,GO:0042795" nucleoplasm|membrane|integral component of membrane|snRNA processing|nuclear membrane|integrator complex|U2 snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS10 677.009774 750.0524606 603.9670873 0.805233126 -0.312521572 0.411948522 1 12.09408185 10.1580528 55174 integrator complex subunit 10 "GO:0005515,GO:0005634,GO:0005654,GO:0016180,GO:0032039,GO:0042795" protein binding|nucleus|nucleoplasm|snRNA processing|integrator complex|snRNA transcription by RNA polymerase II INTS11 1501.375961 1504.164745 1498.587178 0.996291917 -0.005359576 0.989372359 1 29.41337373 30.56661718 54973 integrator complex subunit 11 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016180,GO:0016787,GO:0032039,GO:0042795,GO:0072562" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|snRNA processing|hydrolase activity|integrator complex|snRNA transcription by RNA polymerase II|blood microparticle INTS12 304.9418124 336.9653815 272.9182434 0.80992962 -0.304131547 0.520132176 1 6.627614691 5.599128873 57117 integrator complex subunit 12 "GO:0005515,GO:0005634,GO:0005654,GO:0016180,GO:0032039,GO:0034472,GO:0042795,GO:0046872" protein binding|nucleus|nucleoplasm|snRNA processing|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II|metal ion binding INTS13 692.204422 778.4712277 605.9376162 0.778368673 -0.361474449 0.340011635 1 14.21298537 11.53948925 55726 integrator complex subunit 13 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007052,GO:0007346,GO:0016604,GO:0030317,GO:0032039,GO:0042795,GO:0043231,GO:0051301,GO:0051642,GO:0080154,GO:0090435" protein binding|nucleus|nucleoplasm|cytoplasm|mitotic spindle organization|regulation of mitotic cell cycle|nuclear body|flagellated sperm motility|integrator complex|snRNA transcription by RNA polymerase II|intracellular membrane-bounded organelle|cell division|centrosome localization|regulation of fertilization|protein localization to nuclear envelope INTS14 994.2458649 984.5072893 1003.98444 1.019783654 0.028263118 0.939100371 1 18.61905193 19.8053052 81556 integrator complex subunit 14 "GO:0005654,GO:0032039,GO:0034472,GO:0042795" nucleoplasm|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS2 673.8637073 703.3644861 644.3629284 0.916115245 -0.126398998 0.742582051 1 5.48298136 5.239415125 57508 integrator complex subunit 2 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016020,GO:0016021,GO:0016180,GO:0031965,GO:0032039,GO:0034472,GO:0042795" protein binding|nucleus|nucleoplasm|cytoplasm|membrane|integral component of membrane|snRNA processing|nuclear membrane|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS3 2277.84078 2216.663835 2339.017725 1.055197314 0.077512797 0.809591387 1 22.86015136 25.16104696 65123 integrator complex subunit 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006974,GO:0010212,GO:0016180,GO:0032039,GO:0035861,GO:0042795,GO:0044818,GO:0070876" protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|cellular response to DNA damage stimulus|response to ionizing radiation|snRNA processing|integrator complex|site of double-strand break|snRNA transcription by RNA polymerase II|mitotic G2/M transition checkpoint|SOSS complex INTS4 756.6231966 736.858033 776.3883602 1.053647142 0.0753918 0.842266216 1 10.14937718 11.15451047 92105 integrator complex subunit 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0016180,GO:0032039,GO:0042795" protein binding|nucleus|nucleoplasm|nucleolus|snRNA processing|integrator complex|snRNA transcription by RNA polymerase II INTS5 750.2756394 774.4114039 726.139875 0.937666816 -0.092852719 0.80582182 1 11.93948422 11.67750446 80789 integrator complex subunit 5 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016020,GO:0016021,GO:0016180,GO:0031965,GO:0032039,GO:0034472,GO:0042795" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|integral component of membrane|snRNA processing|nuclear membrane|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS6 1047.251705 1038.299956 1056.203455 1.017243089 0.024664479 0.946634259 1 2.247178747 2.384395517 26512 integrator complex subunit 6 "GO:0004888,GO:0005515,GO:0005634,GO:0005654,GO:0015629,GO:0016180,GO:0032039,GO:0034472,GO:0042795" transmembrane signaling receptor activity|protein binding|nucleus|nucleoplasm|actin cytoskeleton|snRNA processing|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS6L 426.8661813 454.7002738 399.0320887 0.877571692 -0.188411106 0.661134883 1 3.732409203 3.416550049 203522 integrator complex subunit 6 like "GO:0032039,GO:0034472" integrator complex|snRNA 3'-end processing INTS7 826.4324718 861.6976171 791.1673265 0.918149605 -0.123198847 0.737895927 1 8.231223014 7.883040354 25896 integrator complex subunit 7 "GO:0000077,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0016180,GO:0016604,GO:0032039,GO:0034472,GO:0042795,GO:0071479" DNA damage checkpoint|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|snRNA processing|nuclear body|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II|cellular response to ionizing radiation INTS8 1791.795391 1622.914593 1960.676189 1.208120376 0.272764211 0.401750667 1 9.786272039 12.33228132 55656 integrator complex subunit 8 "GO:0005515,GO:0005654,GO:0016180,GO:0032039,GO:0034472,GO:0042795" protein binding|nucleoplasm|snRNA processing|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS9 430.8369305 456.7301858 404.9436752 0.886614653 -0.173620889 0.685914248 1 7.336432814 6.784780141 55756 integrator complex subunit 9 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0016180,GO:0032039,GO:0042795" protein binding|nucleus|nucleoplasm|cytosol|snRNA processing|integrator complex|snRNA transcription by RNA polymerase II INTU 89.48759356 89.31612522 89.65906191 1.003839583 0.00552874 1 1 0.862778305 0.903398703 27152 inturned planar cell polarity protein "GO:0001736,GO:0005515,GO:0005737,GO:0007399,GO:0008589,GO:0009986,GO:0010839,GO:0016192,GO:0021513,GO:0021915,GO:0030216,GO:0030278,GO:0031069,GO:0031514,GO:0036064,GO:0042733,GO:0043587,GO:0044458,GO:0045880,GO:0051782,GO:0060021,GO:0060173,GO:0060271,GO:1905515" establishment of planar polarity|protein binding|cytoplasm|nervous system development|regulation of smoothened signaling pathway|cell surface|negative regulation of keratinocyte proliferation|vesicle-mediated transport|spinal cord dorsal/ventral patterning|neural tube development|keratinocyte differentiation|regulation of ossification|hair follicle morphogenesis|motile cilium|ciliary basal body|embryonic digit morphogenesis|tongue morphogenesis|motile cilium assembly|positive regulation of smoothened signaling pathway|negative regulation of cell division|roof of mouth development|limb development|cilium assembly|non-motile cilium assembly INVS 677.0449087 685.0952787 668.9945388 0.976498539 -0.034310209 0.932136917 1 6.945087869 7.074003534 27130 inversin "GO:0005515,GO:0005516,GO:0005634,GO:0005737,GO:0005819,GO:0005874,GO:0005929,GO:0007275,GO:0016020,GO:0016055,GO:0090090,GO:0097543,GO:1904108" protein binding|calmodulin binding|nucleus|cytoplasm|spindle|microtubule|cilium|multicellular organism development|membrane|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|ciliary inversin compartment|protein localization to ciliary inversin compartment hsa04310 Wnt signaling pathway IP6K1 2011.001632 1992.358566 2029.644698 1.018714569 0.026749883 0.935393395 1 19.98928937 21.24055215 9807 inositol hexakisphosphate kinase 1 "GO:0000827,GO:0000828,GO:0000832,GO:0001650,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016301,GO:0032958,GO:0043647,GO:0046854,GO:0052723,GO:0052724,GO:0120163" "inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|fibrillar center|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|kinase activity|inositol phosphate biosynthetic process|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|negative regulation of cold-induced thermogenesis" hsa04070 Phosphatidylinositol signaling system IP6K2 1226.419887 1230.126634 1222.713141 0.993973391 -0.008720865 0.982265453 1 11.93745437 12.37663013 51447 inositol hexakisphosphate kinase 2 "GO:0000828,GO:0000832,GO:0001650,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006817,GO:0016301,GO:0030054,GO:0030308,GO:0032958,GO:0043065,GO:0043647,GO:0046854,GO:0060337,GO:0097243,GO:1905396" inositol hexakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|fibrillar center|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|phosphate ion transport|kinase activity|cell junction|negative regulation of cell growth|inositol phosphate biosynthetic process|positive regulation of apoptotic process|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|type I interferon signaling pathway|flavonoid binding|cellular response to flavonoid hsa04070 Phosphatidylinositol signaling system IPMK 428.4398335 562.2856065 294.5940605 0.523922464 -0.932574773 0.0290879 0.761114664 4.451740244 2.432835618 253430 inositol polyphosphate multikinase "GO:0000823,GO:0000824,GO:0000825,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0008440,GO:0016301,GO:0032957,GO:0032958,GO:0043647,GO:0046854,GO:0046872,GO:0046934,GO:0047326,GO:0051765,GO:0052812,GO:0070266,GO:0097243,GO:0102732" "inositol-1,4,5-trisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol tetrakisphosphate 6-kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|inositol-1,4,5-trisphosphate 3-kinase activity|kinase activity|inositol trisphosphate metabolic process|inositol phosphate biosynthetic process|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|metal ion binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|inositol tetrakisphosphate 5-kinase activity|inositol tetrakisphosphate kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|necroptotic process|flavonoid binding|myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system IPO11 963.1979116 949.9987864 976.3970368 1.027787667 0.039542246 0.914141306 1 10.43915972 11.19141175 51194 importin 11 "GO:0005515,GO:0005635,GO:0005654,GO:0005829,GO:0006606,GO:0006610,GO:0061608" protein binding|nuclear envelope|nucleoplasm|cytosol|protein import into nucleus|ribosomal protein import into nucleus|nuclear import signal receptor activity IPO13 1243.552651 1290.009036 1197.096266 0.927975102 -0.107841998 0.752816805 1 15.38366065 14.89059134 9670 importin 13 "GO:0005515,GO:0005634,GO:0005737,GO:0006606" protein binding|nucleus|cytoplasm|protein import into nucleus IPO4 1170.285302 1467.62633 872.9442731 0.59480009 -0.74952323 0.029560576 0.763169617 21.24931279 13.18353403 79711 importin 4 "GO:0000785,GO:0005515,GO:0005634,GO:0005737,GO:0006335,GO:0006336,GO:0006606,GO:0008139,GO:0016020,GO:0032991,GO:0061608" chromatin|protein binding|nucleus|cytoplasm|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|protein import into nucleus|nuclear localization sequence binding|membrane|protein-containing complex|nuclear import signal receptor activity IPO5 6747.744706 7016.390609 6479.098803 0.923423333 -0.114935908 0.725205299 1 57.17706066 55.07298287 3843 importin 5 "GO:0003723,GO:0005095,GO:0005515,GO:0005634,GO:0005643,GO:0005730,GO:0005737,GO:0006606,GO:0006607,GO:0006610,GO:0008139,GO:0016020,GO:0016032,GO:0031267,GO:0034260,GO:0042307,GO:0045736,GO:0061608,GO:0071230" RNA binding|GTPase inhibitor activity|protein binding|nucleus|nuclear pore|nucleolus|cytoplasm|protein import into nucleus|NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|nuclear localization sequence binding|membrane|viral process|small GTPase binding|negative regulation of GTPase activity|positive regulation of protein import into nucleus|negative regulation of cyclin-dependent protein serine/threonine kinase activity|nuclear import signal receptor activity|cellular response to amino acid stimulus IPO7 11103.78873 9454.314845 12753.26261 1.348935678 0.431821557 0.204116775 1 77.70653913 109.3363919 10527 importin 7 "GO:0005215,GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005829,GO:0006606,GO:0007165,GO:0016020,GO:0016032,GO:0030695,GO:0031267,GO:0042393,GO:0045087,GO:0045736,GO:0046332" transporter activity|protein binding|nuclear envelope|nuclear pore|nucleoplasm|cytosol|protein import into nucleus|signal transduction|membrane|viral process|GTPase regulator activity|small GTPase binding|histone binding|innate immune response|negative regulation of cyclin-dependent protein serine/threonine kinase activity|SMAD binding IPO8 1554.619334 1574.196707 1535.041961 0.975127158 -0.036337734 0.914256066 1 13.10876517 13.33334036 10526 importin 8 "GO:0005515,GO:0005635,GO:0005654,GO:0005829,GO:0006606,GO:0007165,GO:0031267,GO:0060964" protein binding|nuclear envelope|nucleoplasm|cytosol|protein import into nucleus|signal transduction|small GTPase binding|regulation of gene silencing by miRNA IPO9 5059.708643 5111.318257 5008.099029 0.979805752 -0.029432334 0.92760111 1 22.67608953 23.17523131 55705 importin 9 "GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0006606,GO:0016020,GO:0042393,GO:0061608" protein binding|nuclear envelope|cytoplasm|cytosol|protein import into nucleus|membrane|histone binding|nuclear import signal receptor activity IPP 271.5967232 280.1278473 263.0655992 0.939091211 -0.090662806 0.859445412 1 3.284900957 3.217703221 3652 intracisternal A particle-promoted polypeptide "GO:0003779,GO:0005737,GO:0015629" actin binding|cytoplasm|actin cytoskeleton IPPK 492.9476828 526.7621476 459.1332181 0.871613916 -0.198238865 0.63117014 1 5.965707618 5.423779805 64768 inositol-pentakisphosphate 2-kinase "GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0032958,GO:0035299,GO:0043647,GO:0052746,GO:0060090,GO:1901838" protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytosol|inositol phosphate biosynthetic process|inositol pentakisphosphate 2-kinase activity|inositol phosphate metabolic process|inositol phosphorylation|molecular adaptor activity|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system IQANK1 37.00407712 37.55337083 36.45478341 0.970745971 -0.042834281 0.996505263 1 0.39948451 0.404502743 642574 IQ motif and ankyrin repeat containing 1 "GO:0005634,GO:0005737,GO:2000812" nucleus|cytoplasm|regulation of barbed-end actin filament capping IQCB1 387.0305203 358.2794568 415.7815838 1.160495183 0.214740534 0.62660808 1 6.337963868 7.672007714 9657 IQ motif containing B1 "GO:0001750,GO:0005515,GO:0005516,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0015630,GO:0019899,GO:0032391,GO:0045171,GO:0045494,GO:0048496,GO:0060271,GO:0070062,GO:0072686,GO:0097711" photoreceptor outer segment|protein binding|calmodulin binding|nucleoplasm|centrosome|centriole|cytosol|cilium|microtubule cytoskeleton|enzyme binding|photoreceptor connecting cilium|intercellular bridge|photoreceptor cell maintenance|maintenance of animal organ identity|cilium assembly|extracellular exosome|mitotic spindle|ciliary basal body-plasma membrane docking IQCC 116.2678821 101.4955968 131.0401674 1.291092141 0.368591964 0.572892494 1 2.554867756 3.440658684 55721 IQ motif containing C GO:0005515 protein binding IQCD 1062.686361 1419.9234 705.4493222 0.496822098 -1.009198751 0.004076224 0.236073713 23.78112137 12.32392831 115811 IQ motif containing D "GO:0005737,GO:0031514,GO:0036064" cytoplasm|motile cilium|ciliary basal body IQCE 712.9503984 647.5419078 778.3588891 1.202020873 0.265461948 0.48131893 1 4.244850277 5.322189274 23288 IQ motif containing E "GO:0005515,GO:0005929,GO:0035108,GO:0060170" protein binding|cilium|limb morphogenesis|ciliary membrane IQCG 102.4741803 101.4955968 103.4527637 1.019283269 0.027555047 0.98362538 1 1.682616669 1.788940978 84223 IQ motif containing G "GO:0002177,GO:0005516,GO:0005737,GO:0005829,GO:0007286,GO:0007288,GO:0030544,GO:0031514,GO:0036126,GO:0044782,GO:0070062" manchette|calmodulin binding|cytoplasm|cytosol|spermatid development|sperm axoneme assembly|Hsp70 protein binding|motile cilium|sperm flagellum|cilium organization|extracellular exosome IQCH 20.55421916 24.35894324 16.74949508 0.687611729 -0.540333941 0.647675754 1 0.218895412 0.156998631 64799 IQ motif containing H "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process IQCK 79.24623762 96.420817 62.07165824 0.643757854 -0.635409966 0.387957279 1 1.525577703 1.024407627 124152 IQ motif containing K IQCN 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.047289733 0.011970944 80726 IQ motif containing N "GO:0005515,GO:0005634,GO:0005739" protein binding|nucleus|mitochondrion IQGAP1 15153.4279 15597.84332 14709.01247 0.943015786 -0.084646174 0.809421146 1 109.6427118 107.848637 8826 IQ motif containing GTPase activating protein 1 "GO:0001726,GO:0005078,GO:0005095,GO:0005096,GO:0005509,GO:0005515,GO:0005516,GO:0005547,GO:0005634,GO:0005737,GO:0005829,GO:0005874,GO:0005884,GO:0005886,GO:0005925,GO:0007165,GO:0007173,GO:0007346,GO:0015629,GO:0015630,GO:0016032,GO:0016477,GO:0019901,GO:0019903,GO:0019904,GO:0030424,GO:0030426,GO:0030496,GO:0030667,GO:0031234,GO:0031267,GO:0032956,GO:0032991,GO:0034260,GO:0036057,GO:0036464,GO:0043005,GO:0043312,GO:0043406,GO:0043410,GO:0043539,GO:0043547,GO:0044548,GO:0045121,GO:0045296,GO:0045860,GO:0051015,GO:0051019,GO:0051894,GO:0060090,GO:0070062,GO:0071277,GO:0071364,GO:0072015,GO:1900006,GO:1900086,GO:1903829,GO:1904754,GO:1990138,GO:1990776" "ruffle|MAP-kinase scaffold activity|GTPase inhibitor activity|GTPase activator activity|calcium ion binding|protein binding|calmodulin binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|cytoplasm|cytosol|microtubule|actin filament|plasma membrane|focal adhesion|signal transduction|epidermal growth factor receptor signaling pathway|regulation of mitotic cell cycle|actin cytoskeleton|microtubule cytoskeleton|viral process|cell migration|protein kinase binding|protein phosphatase binding|protein domain specific binding|axon|growth cone|midbody|secretory granule membrane|extrinsic component of cytoplasmic side of plasma membrane|small GTPase binding|regulation of actin cytoskeleton organization|protein-containing complex|negative regulation of GTPase activity|slit diaphragm|cytoplasmic ribonucleoprotein granule|neuron projection|neutrophil degranulation|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|protein serine/threonine kinase activator activity|positive regulation of GTPase activity|S100 protein binding|membrane raft|cadherin binding|positive regulation of protein kinase activity|actin filament binding|mitogen-activated protein kinase binding|positive regulation of focal adhesion assembly|molecular adaptor activity|extracellular exosome|cellular response to calcium ion|cellular response to epidermal growth factor stimulus|glomerular visceral epithelial cell development|positive regulation of dendrite development|positive regulation of peptidyl-tyrosine autophosphorylation|positive regulation of cellular protein localization|positive regulation of vascular associated smooth muscle cell migration|neuron projection extension|response to angiotensin" "hsa04520,hsa04810,hsa05205" Adherens junction|Regulation of actin cytoskeleton|Proteoglycans in cancer IQGAP2 29.55521089 33.49354696 25.61687483 0.764830159 -0.386788682 0.718360561 1 0.259536413 0.207051906 10788 IQ motif containing GTPase activating protein 2 "GO:0003779,GO:0005095,GO:0005096,GO:0005516,GO:0005547,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0007165,GO:0009986,GO:0015629,GO:0030027,GO:0030175,GO:0030667,GO:0031267,GO:0032956,GO:0034260,GO:0034314,GO:0043312,GO:0043547,GO:0051015,GO:0070062,GO:0070493,GO:0071933,GO:2000249" "actin binding|GTPase inhibitor activity|GTPase activator activity|calmodulin binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|plasma membrane|microvillus|signal transduction|cell surface|actin cytoskeleton|lamellipodium|filopodium|secretory granule membrane|small GTPase binding|regulation of actin cytoskeleton organization|negative regulation of GTPase activity|Arp2/3 complex-mediated actin nucleation|neutrophil degranulation|positive regulation of GTPase activity|actin filament binding|extracellular exosome|thrombin-activated receptor signaling pathway|Arp2/3 complex binding|regulation of actin cytoskeleton reorganization" hsa04810 Regulation of actin cytoskeleton IQGAP3 3339.081158 2325.264124 4352.898192 1.872001614 0.904581679 0.004729715 0.257018659 17.79755551 34.75221615 128239 IQ motif containing GTPase activating protein 3 "GO:0000082,GO:0000187,GO:0005096,GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0005911,GO:0007265,GO:0008361,GO:0010628,GO:0010629,GO:0016328,GO:0032956,GO:0033601,GO:0043547,GO:0051015,GO:0070371,GO:0070856,GO:0071310" G1/S transition of mitotic cell cycle|activation of MAPK activity|GTPase activator activity|protein binding|calmodulin binding|cytoplasm|cytosol|cell-cell junction|Ras protein signal transduction|regulation of cell size|positive regulation of gene expression|negative regulation of gene expression|lateral plasma membrane|regulation of actin cytoskeleton organization|positive regulation of mammary gland epithelial cell proliferation|positive regulation of GTPase activity|actin filament binding|ERK1 and ERK2 cascade|myosin VI light chain binding|cellular response to organic substance hsa04810 Regulation of actin cytoskeleton IQSEC1 1144.533823 919.5501073 1369.517539 1.489334326 0.574667646 0.095788543 1 4.526824354 7.032370971 9922 IQ motif and Sec7 domain ArfGEF 1 "GO:0005085,GO:0005515,GO:0005730,GO:0008021,GO:0008289,GO:0014069,GO:0016020,GO:0030036,GO:0032012,GO:0043231,GO:0043547,GO:0051549,GO:0060996,GO:0120183" guanyl-nucleotide exchange factor activity|protein binding|nucleolus|synaptic vesicle|lipid binding|postsynaptic density|membrane|actin cytoskeleton organization|regulation of ARF protein signal transduction|intracellular membrane-bounded organelle|positive regulation of GTPase activity|positive regulation of keratinocyte migration|dendritic spine development|positive regulation of focal adhesion disassembly hsa04144 Endocytosis IQSEC2 276.58515 250.6941242 302.4761759 1.206554708 0.270893333 0.579718066 1 0.886027425 1.115090493 23096 IQ motif and Sec7 domain ArfGEF 2 "GO:0005085,GO:0005737,GO:0030036,GO:0032012,GO:0050790,GO:0050804,GO:0098685,GO:0098696" guanyl-nucleotide exchange factor activity|cytoplasm|actin cytoskeleton organization|regulation of ARF protein signal transduction|regulation of catalytic activity|modulation of chemical synaptic transmission|Schaffer collateral - CA1 synapse|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane hsa04144 Endocytosis IQUB 7.508249331 8.119647747 6.896850916 0.849402724 -0.235479359 0.974243744 1 0.050687972 0.044909115 154865 IQ motif and ubiquitin domain containing "GO:0001669,GO:0005515,GO:0007224,GO:0031514,GO:0060271" acrosomal vesicle|protein binding|smoothened signaling pathway|motile cilium|cilium assembly IRAK1 3859.134006 3458.96994 4259.298073 1.231377591 0.300273219 0.345948615 1 48.92058781 62.83459821 3654 interleukin 1 receptor associated kinase 1 "GO:0000187,GO:0001959,GO:0002224,GO:0002755,GO:0004672,GO:0004674,GO:0004704,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005811,GO:0005829,GO:0005886,GO:0006468,GO:0007250,GO:0007254,GO:0007568,GO:0010008,GO:0016032,GO:0016301,GO:0019221,GO:0031072,GO:0031663,GO:0032088,GO:0032481,GO:0032496,GO:0032991,GO:0034134,GO:0034142,GO:0034162,GO:0034605,GO:0035556,GO:0042802,GO:0042803,GO:0043066,GO:0043123,GO:0043406,GO:0045087,GO:0046777,GO:0046982,GO:0048661,GO:0051092,GO:0060337,GO:0070423,GO:0070498,GO:0070555,GO:0071222,GO:0071456,GO:0106310,GO:0106311,GO:1901224,GO:1904996" activation of MAPK activity|regulation of cytokine-mediated signaling pathway|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|NF-kappaB-inducing kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|lipid droplet|cytosol|plasma membrane|protein phosphorylation|activation of NF-kappaB-inducing kinase activity|JNK cascade|aging|endosome membrane|viral process|kinase activity|cytokine-mediated signaling pathway|heat shock protein binding|lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of type I interferon production|response to lipopolysaccharide|protein-containing complex|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 9 signaling pathway|cellular response to heat|intracellular signal transduction|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|innate immune response|protein autophosphorylation|protein heterodimerization activity|positive regulation of smooth muscle cell proliferation|positive regulation of NF-kappaB transcription factor activity|type I interferon signaling pathway|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-1|cellular response to lipopolysaccharide|cellular response to hypoxia|protein serine kinase activity|protein threonine kinase activity|positive regulation of NIK/NF-kappaB signaling|positive regulation of leukocyte adhesion to vascular endothelial cell "hsa04010,hsa04064,hsa04620,hsa04722,hsa05130,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05171" MAPK signaling pathway|NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Neurotrophin signaling pathway|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 IRAK1BP1 115.7455584 99.4656849 132.0254318 1.327346531 0.408545065 0.531461942 1 0.865564613 1.198394319 134728 interleukin 1 receptor associated kinase 1 binding protein 1 "GO:0005515,GO:0005634,GO:0005737,GO:0006955,GO:0007249" protein binding|nucleus|cytoplasm|immune response|I-kappaB kinase/NF-kappaB signaling IRAK2 3011.621532 3715.7538 2307.489264 0.621001656 -0.687330979 0.031288264 0.79267501 54.84984599 35.52909134 3656 interleukin 1 receptor associated kinase 2 "GO:0000187,GO:0001959,GO:0002224,GO:0002755,GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006954,GO:0007249,GO:0007254,GO:0010008,GO:0019221,GO:0031663,GO:0032088,GO:0034162,GO:0035556,GO:0042803,GO:0046982,GO:0051092,GO:0070423,GO:0070498,GO:0070555" activation of MAPK activity|regulation of cytokine-mediated signaling pathway|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|inflammatory response|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|cytokine-mediated signaling pathway|lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|toll-like receptor 9 signaling pathway|intracellular signal transduction|protein homodimerization activity|protein heterodimerization activity|positive regulation of NF-kappaB transcription factor activity|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-1 "hsa04722,hsa05152" Neurotrophin signaling pathway|Tuberculosis IRAK3 3316.996593 4048.659358 2585.333829 0.638565412 -0.647093685 0.042485002 0.940614529 24.62179559 16.39989404 11213 interleukin 1 receptor associated kinase 3 "GO:0000287,GO:0001960,GO:0002755,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0006468,GO:0009615,GO:0010933,GO:0010936,GO:0019221,GO:0032088,GO:0032494,GO:0032496,GO:0032695,GO:0032715,GO:0032720,GO:0034122,GO:0035556,GO:0042177,GO:0042803,GO:0043242,GO:0043244,GO:0043330,GO:0043407,GO:0045824,GO:0046777,GO:0046982,GO:0051092,GO:0070498,GO:0070555,GO:0106310,GO:0106311" magnesium ion binding|negative regulation of cytokine-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|protein phosphorylation|response to virus|positive regulation of macrophage tolerance induction|negative regulation of macrophage cytokine production|cytokine-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|response to peptidoglycan|response to lipopolysaccharide|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|intracellular signal transduction|negative regulation of protein catabolic process|protein homodimerization activity|negative regulation of protein-containing complex disassembly|regulation of protein-containing complex disassembly|response to exogenous dsRNA|negative regulation of MAP kinase activity|negative regulation of innate immune response|protein autophosphorylation|protein heterodimerization activity|positive regulation of NF-kappaB transcription factor activity|interleukin-1-mediated signaling pathway|response to interleukin-1|protein serine kinase activity|protein threonine kinase activity hsa04722 Neurotrophin signaling pathway IRAK4 314.6608446 327.8307778 301.4909115 0.919654077 -0.120836793 0.800759708 1 2.717870744 2.607169274 51135 interleukin 1 receptor associated kinase 4 "GO:0000287,GO:0002224,GO:0002446,GO:0002755,GO:0004672,GO:0004674,GO:0005149,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007254,GO:0010008,GO:0019221,GO:0034162,GO:0035556,GO:0043123,GO:0045087,GO:0048661,GO:0070498,GO:0106310,GO:0106311,GO:1990266" magnesium ion binding|toll-like receptor signaling pathway|neutrophil mediated immunity|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|interleukin-1 receptor binding|protein binding|ATP binding|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|JNK cascade|endosome membrane|cytokine-mediated signaling pathway|toll-like receptor 9 signaling pathway|intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of smooth muscle cell proliferation|interleukin-1-mediated signaling pathway|protein serine kinase activity|protein threonine kinase activity|neutrophil migration "hsa04010,hsa04064,hsa04620,hsa04621,hsa04722,hsa05130,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05170,hsa05171" MAPK signaling pathway|NF-kappa B signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Neurotrophin signaling pathway|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 IREB2 2113.687613 2243.05269 1984.322535 0.884652663 -0.176816968 0.582343026 1 16.11157364 14.86711427 3658 iron responsive element binding protein 2 "GO:0003723,GO:0003994,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006099,GO:0006101,GO:0006782,GO:0006826,GO:0006879,GO:0009791,GO:0017148,GO:0030316,GO:0030350,GO:0030371,GO:0034101,GO:0046872,GO:0050892,GO:0051539,GO:0055072" "RNA binding|aconitate hydratase activity|protein binding|cytoplasm|mitochondrion|cytosol|tricarboxylic acid cycle|citrate metabolic process|protoporphyrinogen IX biosynthetic process|iron ion transport|cellular iron ion homeostasis|post-embryonic development|negative regulation of translation|osteoclast differentiation|iron-responsive element binding|translation repressor activity|erythrocyte homeostasis|metal ion binding|intestinal absorption|4 iron, 4 sulfur cluster binding|iron ion homeostasis" IRF1 670.4652623 639.4222601 701.5082646 1.097097033 0.133691131 0.728384674 1 9.071283397 10.38077327 3659 interferon regulatory factor 1 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0002376,GO:0002819,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006915,GO:0007050,GO:0007596,GO:0008285,GO:0032481,GO:0032728,GO:0032735,GO:0034124,GO:0035458,GO:0043374,GO:0045088,GO:0045590,GO:0045892,GO:0045893,GO:0045944,GO:0051607,GO:0051726,GO:0060333,GO:0060337,GO:0071260,GO:2000564" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|immune system process|regulation of adaptive immune response|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|apoptotic process|cell cycle arrest|blood coagulation|negative regulation of cell population proliferation|positive regulation of type I interferon production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|regulation of MyD88-dependent toll-like receptor signaling pathway|cellular response to interferon-beta|CD8-positive, alpha-beta T cell differentiation|regulation of innate immune response|negative regulation of regulatory T cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|defense response to virus|regulation of cell cycle|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|cellular response to mechanical stimulus|regulation of CD8-positive, alpha-beta T cell proliferation" "hsa04625,hsa04668,hsa04917,hsa05133,hsa05165" C-type lectin receptor signaling pathway|TNF signaling pathway|Prolactin signaling pathway|Pertussis|Human papillomavirus infection IRF IRF2 566.5104638 571.4202102 561.6007174 0.982815636 -0.025007284 0.954455114 1 3.299933614 3.382931393 3660 interferon regulatory factor 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0002376,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006355,GO:0006357,GO:0007596,GO:0008283,GO:0045944,GO:0051607,GO:0060333,GO:0060337,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|immune system process|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|focal adhesion|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|blood coagulation|cell population proliferation|positive regulation of transcription by RNA polymerase II|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|sequence-specific double-stranded DNA binding" IRF IRF2BP1 481.5780479 456.7301858 506.4259101 1.10880762 0.149009077 0.721189088 1 9.12856064 10.55782445 26145 interferon regulatory factor 2 binding protein 1 "GO:0000122,GO:0000209,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008134,GO:0046872,GO:0061630" negative regulation of transcription by RNA polymerase II|protein polyubiquitination|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|metal ion binding|ubiquitin protein ligase activity IRF2BP2 1560.793939 1827.935699 1293.652179 0.707712082 -0.498765546 0.130918686 1 17.4150667 12.8557578 359948 interferon regulatory factor 2 binding protein 2 "GO:0000122,GO:0002327,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0046872" negative regulation of transcription by RNA polymerase II|immature B cell differentiation|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|metal ion binding IRF2BPL 2408.350459 2315.114564 2501.586354 1.080545383 0.111759667 0.727107861 1 28.14507571 31.72205861 64207 interferon regulatory factor 2 binding protein like "GO:0000122,GO:0003714,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0006357,GO:0007399,GO:0016567,GO:0045944,GO:0046543,GO:0046872,GO:0061630" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|extracellular space|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nervous system development|protein ubiquitination|positive regulation of transcription by RNA polymerase II|development of secondary female sexual characteristics|metal ion binding|ubiquitin protein ligase activity IRF3 903.6745297 821.0993784 986.249681 1.201133148 0.264396085 0.461863441 1 23.07757317 28.91327046 3661 interferon regulatory factor 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0002376,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006357,GO:0006915,GO:0006974,GO:0016032,GO:0019904,GO:0031663,GO:0032479,GO:0032480,GO:0032481,GO:0032727,GO:0032728,GO:0035666,GO:0039530,GO:0042802,GO:0042803,GO:0042981,GO:0043123,GO:0043565,GO:0045944,GO:0050727,GO:0051607,GO:0060333,GO:0060337,GO:0060340,GO:0071360,GO:0071888,GO:0097300,GO:0098586,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|immune system process|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|apoptotic process|cellular response to DNA damage stimulus|viral process|protein domain specific binding|lipopolysaccharide-mediated signaling pathway|regulation of type I interferon production|negative regulation of type I interferon production|positive regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|TRIF-dependent toll-like receptor signaling pathway|MDA-5 signaling pathway|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|regulation of inflammatory response|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|positive regulation of type I interferon-mediated signaling pathway|cellular response to exogenous dsRNA|macrophage apoptotic process|programmed necrotic cell death|cellular response to virus|sequence-specific double-stranded DNA binding" "hsa04620,hsa04621,hsa04622,hsa04623,hsa05131,hsa05133,hsa05135,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05203" Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Shigellosis|Pertussis|Yersinia infection|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Viral carcinogenesis IRF IRF4 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.029036305 0.009800351 3662 interferon regulatory factor 4 "GO:0000785,GO:0000786,GO:0000978,GO:0000981,GO:0001228,GO:0002376,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0008134,GO:0016020,GO:0019221,GO:0032733,GO:0032736,GO:0032743,GO:0032753,GO:0034122,GO:0042110,GO:0042832,GO:0043011,GO:0043388,GO:0043565,GO:0043966,GO:0043967,GO:0045622,GO:0045893,GO:0045944,GO:0060333,GO:0060337,GO:0072540,GO:0120162,GO:1990837" "chromatin|nucleosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|immune system process|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription factor binding|membrane|cytokine-mediated signaling pathway|positive regulation of interleukin-10 production|positive regulation of interleukin-13 production|positive regulation of interleukin-2 production|positive regulation of interleukin-4 production|negative regulation of toll-like receptor signaling pathway|T cell activation|defense response to protozoan|myeloid dendritic cell differentiation|positive regulation of DNA binding|sequence-specific DNA binding|histone H3 acetylation|histone H4 acetylation|regulation of T-helper cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|T-helper 17 cell lineage commitment|positive regulation of cold-induced thermogenesis|sequence-specific double-stranded DNA binding" hsa04659 Th17 cell differentiation IRF IRF5 88.99768296 55.82257826 122.1727877 2.188590915 1.130002316 0.110666682 1 0.705217425 1.609917261 3663 interferon regulatory factor 5 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002376,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006357,GO:0006954,GO:0019221,GO:0019901,GO:0032481,GO:0032494,GO:0032495,GO:0032727,GO:0032728,GO:0032735,GO:0042802,GO:0043065,GO:0043565,GO:0045087,GO:0045944,GO:0051607,GO:0060333,GO:0060337,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|immune system process|protein binding|nucleus|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|inflammatory response|cytokine-mediated signaling pathway|protein kinase binding|positive regulation of type I interferon production|response to peptidoglycan|response to muramyl dipeptide|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|identical protein binding|positive regulation of apoptotic process|sequence-specific DNA binding|innate immune response|positive regulation of transcription by RNA polymerase II|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|sequence-specific double-stranded DNA binding" hsa04620 Toll-like receptor signaling pathway IRF IRF7 376.9700353 344.0700733 409.8699973 1.191239893 0.252463974 0.569449383 1 8.877195825 11.03039231 3665 interferon regulatory factor 7 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0002376,GO:0002819,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006974,GO:0009615,GO:0010008,GO:0016064,GO:0019043,GO:0032479,GO:0032481,GO:0032607,GO:0032608,GO:0032727,GO:0032728,GO:0034124,GO:0034127,GO:0035666,GO:0039530,GO:0045087,GO:0045655,GO:0045893,GO:0045944,GO:0050776,GO:0051607,GO:0060333,GO:0060337,GO:0060340,GO:1990837,GO:2000110" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|immune system process|regulation of adaptive immune response|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|response to virus|endosome membrane|immunoglobulin mediated immune response|establishment of viral latency|regulation of type I interferon production|positive regulation of type I interferon production|interferon-alpha production|interferon-beta production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of MyD88-dependent toll-like receptor signaling pathway|regulation of MyD88-independent toll-like receptor signaling pathway|TRIF-dependent toll-like receptor signaling pathway|MDA-5 signaling pathway|innate immune response|regulation of monocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of immune response|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|positive regulation of type I interferon-mediated signaling pathway|sequence-specific double-stranded DNA binding|negative regulation of macrophage apoptotic process" "hsa04620,hsa04621,hsa04622,hsa04623,hsa05160,hsa05161,hsa05162,hsa05164,hsa05167,hsa05168,hsa05169,hsa05203" Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Viral carcinogenesis IRF9 689.6361027 602.8838452 776.3883602 1.287790951 0.364898417 0.335885629 1 17.15389883 23.04221067 10379 interferon regulatory factor 9 "GO:0000785,GO:0000978,GO:0000981,GO:0002376,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006366,GO:0007166,GO:0051607,GO:0060333,GO:0060337,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|immune system process|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|cell surface receptor signaling pathway|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|sequence-specific double-stranded DNA binding" "hsa04217,hsa04380,hsa04621,hsa04625,hsa04630,hsa05160,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05203" Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Viral carcinogenesis IRGQ 563.6707152 613.0334049 514.3080254 0.838955955 -0.253333024 0.524488618 1 3.20544903 2.805071697 126298 immunity related GTPase Q "GO:0005515,GO:0005525" protein binding|GTP binding IRS1 1406.87693 1543.748028 1270.005833 0.822676894 -0.281602171 0.399791565 1 8.00177992 6.866443201 3667 insulin receptor substrate 1 "GO:0000165,GO:0001784,GO:0005068,GO:0005080,GO:0005158,GO:0005159,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005899,GO:0005901,GO:0007165,GO:0008284,GO:0008286,GO:0010907,GO:0014065,GO:0030159,GO:0032000,GO:0032868,GO:0032869,GO:0038111,GO:0042169,GO:0042593,GO:0043231,GO:0043434,GO:0043548,GO:0043552,GO:0045725,GO:0046326,GO:0046627,GO:0046628,GO:0046676,GO:0048009,GO:0048015,GO:0051897,GO:0071398" MAPK cascade|phosphotyrosine residue binding|transmembrane receptor protein tyrosine kinase adaptor activity|protein kinase C binding|insulin receptor binding|insulin-like growth factor receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|insulin receptor complex|caveola|signal transduction|positive regulation of cell population proliferation|insulin receptor signaling pathway|positive regulation of glucose metabolic process|phosphatidylinositol 3-kinase signaling|signaling receptor complex adaptor activity|positive regulation of fatty acid beta-oxidation|response to insulin|cellular response to insulin stimulus|interleukin-7-mediated signaling pathway|SH2 domain binding|glucose homeostasis|intracellular membrane-bounded organelle|response to peptide hormone|phosphatidylinositol 3-kinase binding|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|negative regulation of insulin receptor signaling pathway|positive regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|insulin-like growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein kinase B signaling|cellular response to fatty acid "hsa04022,hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04722,hsa04910,hsa04920,hsa04923,hsa04930,hsa04931,hsa04932,hsa04935,hsa04960,hsa05010,hsa05206" "cGMP-PKG signaling pathway|FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Neurotrophin signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Regulation of lipolysis in adipocytes|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Alzheimer disease|MicroRNAs in cancer" IRS2 550.7165416 569.3902983 532.0427849 0.934407886 -0.097875645 0.809874426 1 3.535754036 3.44615233 8660 insulin receptor substrate 2 "GO:0000165,GO:0002053,GO:0002903,GO:0005158,GO:0005515,GO:0005829,GO:0005886,GO:0006006,GO:0007165,GO:0007411,GO:0007420,GO:0008284,GO:0008286,GO:0009749,GO:0010748,GO:0010907,GO:0014068,GO:0019216,GO:0019901,GO:0019903,GO:0019904,GO:0030335,GO:0030879,GO:0030890,GO:0032000,GO:0032024,GO:0032869,GO:0032991,GO:0033673,GO:0038111,GO:0043548,GO:0045725,GO:0046326,GO:0046579,GO:0048015,GO:0051897,GO:0055088,GO:0071333,GO:0071889" MAPK cascade|positive regulation of mesenchymal cell proliferation|negative regulation of B cell apoptotic process|insulin receptor binding|protein binding|cytosol|plasma membrane|glucose metabolic process|signal transduction|axon guidance|brain development|positive regulation of cell population proliferation|insulin receptor signaling pathway|response to glucose|negative regulation of long-chain fatty acid import across plasma membrane|positive regulation of glucose metabolic process|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of lipid metabolic process|protein kinase binding|protein phosphatase binding|protein domain specific binding|positive regulation of cell migration|mammary gland development|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of insulin secretion|cellular response to insulin stimulus|protein-containing complex|negative regulation of kinase activity|interleukin-7-mediated signaling pathway|phosphatidylinositol 3-kinase binding|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|positive regulation of Ras protein signal transduction|phosphatidylinositol-mediated signaling|positive regulation of protein kinase B signaling|lipid homeostasis|cellular response to glucose stimulus|14-3-3 protein binding "hsa04022,hsa04068,hsa04140,hsa04152,hsa04211,hsa04213,hsa04910,hsa04920,hsa04923,hsa04930,hsa04931,hsa04932,hsa04935,hsa05010,hsa05206" "cGMP-PKG signaling pathway|FoxO signaling pathway|Autophagy - animal|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Insulin signaling pathway|Adipocytokine signaling pathway|Regulation of lipolysis in adipocytes|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|Growth hormone synthesis, secretion and action|Alzheimer disease|MicroRNAs in cancer" IRX2 250.1193444 226.3351809 273.9035078 1.210167622 0.275206892 0.586317616 1 1.790546462 2.260200954 153572 iroquois homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0030182,GO:0043565,GO:0048468,GO:0072086,GO:0072272" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|neuron differentiation|sequence-specific DNA binding|cell development|specification of loop of Henle identity|proximal/distal pattern formation involved in metanephric nephron development" IRX3 147.2416065 130.9293199 163.5538931 1.249176985 0.320977895 0.595227868 1 2.363188939 3.079203199 79191 iroquois homeobox 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001656,GO:0005634,GO:0005737,GO:0006357,GO:0007498,GO:0030182,GO:0030424,GO:0045665,GO:0045666,GO:0048468,GO:0072086,GO:0097009,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|metanephros development|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|mesoderm development|neuron differentiation|axon|negative regulation of neuron differentiation|positive regulation of neuron differentiation|cell development|specification of loop of Henle identity|energy homeostasis|sequence-specific double-stranded DNA binding" IRX5 27.54014473 30.44867905 24.63161041 0.808954975 -0.305868687 0.790174891 1 0.499067371 0.421113784 10265 iroquois homeobox 5 "GO:0000785,GO:0000978,GO:0000981,GO:0005499,GO:0005634,GO:0006357,GO:0007601,GO:0008406,GO:0030182,GO:0048468,GO:0048701,GO:0050896,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|vitamin D binding|nucleus|regulation of transcription by RNA polymerase II|visual perception|gonad development|neuron differentiation|cell development|embryonic cranial skeleton morphogenesis|response to stimulus|sequence-specific double-stranded DNA binding" ISCA1 528.0851516 571.4202102 484.7500929 0.848325075 -0.237310888 0.557704936 1 14.71297295 13.01903129 81689 iron-sulfur cluster assembly 1 "GO:0005198,GO:0005737,GO:0005739,GO:0005759,GO:0016226,GO:0044281,GO:0046872,GO:0051537,GO:0097428" "structural molecule activity|cytoplasm|mitochondrion|mitochondrial matrix|iron-sulfur cluster assembly|small molecule metabolic process|metal ion binding|2 iron, 2 sulfur cluster binding|protein maturation by iron-sulfur cluster transfer" ISCA2 383.8047815 373.5037964 394.1057666 1.055158664 0.077459952 0.865316995 1 7.329193973 8.066588719 122961 iron-sulfur cluster assembly 2 "GO:0005198,GO:0005506,GO:0005515,GO:0005739,GO:0005759,GO:0016226,GO:0044281,GO:0051537,GO:0051539,GO:0106035" "structural molecule activity|iron ion binding|protein binding|mitochondrion|mitochondrial matrix|iron-sulfur cluster assembly|small molecule metabolic process|2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|protein maturation by [4Fe-4S] cluster transfer" ISCU 794.514061 700.3196182 888.7085037 1.269004153 0.34369679 0.35048974 1 10.47820327 13.86965928 23479 iron-sulfur cluster assembly enzyme "GO:0005506,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006879,GO:0008198,GO:0016226,GO:0044281,GO:0051537,GO:0051539,GO:0060090,GO:1902958,GO:1904234,GO:1904439" "iron ion binding|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|cellular iron ion homeostasis|ferrous iron binding|iron-sulfur cluster assembly|small molecule metabolic process|2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|molecular adaptor activity|positive regulation of mitochondrial electron transport, NADH to ubiquinone|positive regulation of aconitate hydratase activity|negative regulation of iron ion import across plasma membrane" ISG15 724.8354301 988.5671132 461.1037469 0.466436462 -1.100247524 0.003623226 0.216340112 78.59880193 38.24056925 9636 ISG15 ubiquitin like modifier "GO:0005178,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007229,GO:0016032,GO:0016567,GO:0019941,GO:0019985,GO:0022627,GO:0030501,GO:0031386,GO:0031397,GO:0031625,GO:0032020,GO:0032480,GO:0032609,GO:0032613,GO:0032649,GO:0034340,GO:0042742,GO:0045071,GO:0045648,GO:0051607,GO:0060337" integrin binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|integrin-mediated signaling pathway|viral process|protein ubiquitination|modification-dependent protein catabolic process|translesion synthesis|cytosolic small ribosomal subunit|positive regulation of bone mineralization|protein tag|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|ISG15-protein conjugation|negative regulation of type I interferon production|interferon-gamma production|interleukin-10 production|regulation of interferon-gamma production|response to type I interferon|defense response to bacterium|negative regulation of viral genome replication|positive regulation of erythrocyte differentiation|defense response to virus|type I interferon signaling pathway "hsa04622,hsa05165,hsa05169,hsa05171" RIG-I-like receptor signaling pathway|Human papillomavirus infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 ISG20 250.5120155 354.219633 146.8043981 0.414444555 -1.270748987 0.012071146 0.485496492 3.215625524 1.390105734 3669 interferon stimulated exonuclease gene 20 "GO:0000175,GO:0000738,GO:0004527,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0006401,GO:0008310,GO:0008859,GO:0009615,GO:0015030,GO:0016605,GO:0030619,GO:0030620,GO:0034511,GO:0045071,GO:0046872,GO:0051607,GO:0060337,GO:0090503" "3'-5'-exoribonuclease activity|DNA catabolic process, exonucleolytic|exonuclease activity|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|RNA catabolic process|single-stranded DNA 3'-5' exodeoxyribonuclease activity|exoribonuclease II activity|response to virus|Cajal body|PML body|U1 snRNA binding|U2 snRNA binding|U3 snoRNA binding|negative regulation of viral genome replication|metal ion binding|defense response to virus|type I interferon signaling pathway|RNA phosphodiester bond hydrolysis, exonucleolytic" ISG20L2 935.216353 1024.090572 846.3421338 0.826432893 -0.275030419 0.44103714 1 14.75578228 12.71996049 81875 interferon stimulated exonuclease gene 20 like 2 "GO:0000175,GO:0003723,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0090503" "3'-5'-exoribonuclease activity|RNA binding|exonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|rRNA processing|RNA phosphodiester bond hydrolysis, exonucleolytic" ISL2 50.42391295 45.67301858 55.17480733 1.20803943 0.272667544 0.764255338 1 1.263340943 1.5919067 64843 ISL LIM homeobox 2 "GO:0000785,GO:0000981,GO:0000987,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007409,GO:0021520,GO:0021524,GO:0031290,GO:0045665,GO:0046872,GO:0048665,GO:0048666,GO:0048935,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|axonogenesis|spinal cord motor neuron cell fate specification|visceral motor neuron differentiation|retinal ganglion cell axon guidance|negative regulation of neuron differentiation|metal ion binding|neuron fate specification|neuron development|peripheral nervous system neuron development|sequence-specific double-stranded DNA binding" ISLR2 10.62734612 19.2841634 1.970528833 0.102183786 -3.290761795 0.034608132 0.835969212 0.171136297 0.018240639 57611 immunoglobulin superfamily containing leucine rich repeat 2 "GO:0005515,GO:0005886,GO:0009986,GO:0016021,GO:0045773" protein binding|plasma membrane|cell surface|integral component of membrane|positive regulation of axon extension ISM1 3.47811701 2.029911937 4.926322083 2.426864926 1.279093814 0.644064692 1 0.029474736 0.074612477 140862 isthmin 1 "GO:0005576,GO:0016525" extracellular region|negative regulation of angiogenesis ISM2 16.9870275 16.23929549 17.7347595 1.092089217 0.12709072 0.968752845 1 0.262097842 0.298564037 145501 isthmin 2 "GO:0005515,GO:0005576" protein binding|extracellular region ISOC1 566.1365978 579.5398579 552.7333377 0.953745165 -0.068324256 0.867196098 1 15.11413456 15.03597391 51015 isochorismatase domain containing 1 "GO:0003674,GO:0005515,GO:0005737,GO:0005777,GO:0008150" molecular_function|protein binding|cytoplasm|peroxisome|biological_process ISOC2 640.0084185 679.0055428 601.0112941 0.885134592 -0.176031249 0.649742783 1 30.62264947 28.27274698 79763 isochorismatase domain containing 2 "GO:0005515,GO:0005634,GO:0005737,GO:0031648" protein binding|nucleus|cytoplasm|protein destabilization IST1 1831.456862 1842.145083 1820.768642 0.988395897 -0.016839073 0.96042026 1 19.39267299 19.99330254 9798 IST1 factor associated with ESCRT-III "GO:0000785,GO:0005515,GO:0005576,GO:0005635,GO:0005793,GO:0005813,GO:0005829,GO:0008104,GO:0009838,GO:0015031,GO:0019076,GO:0019904,GO:0030496,GO:0035578,GO:0036258,GO:0043231,GO:0043312,GO:0044877,GO:0045184,GO:0045296,GO:0045862,GO:0046745,GO:0048672,GO:0051301,GO:0061640,GO:0070062,GO:0090541,GO:0090543,GO:1904903" chromatin|protein binding|extracellular region|nuclear envelope|endoplasmic reticulum-Golgi intermediate compartment|centrosome|cytosol|protein localization|abscission|protein transport|viral release from host cell|protein domain specific binding|midbody|azurophil granule lumen|multivesicular body assembly|intracellular membrane-bounded organelle|neutrophil degranulation|protein-containing complex binding|establishment of protein localization|cadherin binding|positive regulation of proteolysis|viral capsid secondary envelopment|positive regulation of collateral sprouting|cell division|cytoskeleton-dependent cytokinesis|extracellular exosome|MIT domain binding|Flemming body|ESCRT III complex disassembly hsa04144 Endocytosis ISY1 199.1555403 211.1108414 187.2002391 0.886739108 -0.173418391 0.75458858 1 2.907019947 2.688808076 57461 ISY1 splicing factor homolog "GO:0000350,GO:0000389,GO:0000398,GO:0000974,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006283,GO:0071006,GO:0071013,GO:0071014,GO:0071020" "generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|Prp19 complex|RNA binding|protein binding|nucleus|nucleoplasm|transcription-coupled nucleotide-excision repair|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex|post-spliceosomal complex" hsa03040 Spliceosome ISYNA1 458.9560605 526.7621476 391.1499734 0.742555203 -0.429429812 0.304220258 1 10.32455281 7.996794308 51477 inositol-3-phosphate synthase 1 "GO:0004512,GO:0005515,GO:0005737,GO:0005829,GO:0006021,GO:0008654,GO:0043647" inositol-3-phosphate synthase activity|protein binding|cytoplasm|cytosol|inositol biosynthetic process|phospholipid biosynthetic process|inositol phosphate metabolic process hsa00562 Inositol phosphate metabolism ITCH 4629.556102 4499.299808 4759.812396 1.057900696 0.081204209 0.800165306 1 25.47782454 28.11403459 83737 itchy E3 ubiquitin protein ligase "GO:0000209,GO:0001558,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0006511,GO:0006915,GO:0006954,GO:0007219,GO:0016020,GO:0016567,GO:0031410,GO:0031901,GO:0032088,GO:0032480,GO:0032991,GO:0035519,GO:0043021,GO:0043066,GO:0043161,GO:0043231,GO:0044389,GO:0045087,GO:0045236,GO:0045732,GO:0046329,GO:0046718,GO:0050687,GO:0051607,GO:0051865,GO:0061630,GO:0070062,GO:0070423,GO:0070534,GO:0070936,GO:0090085,GO:1902036,GO:1990763,GO:2000646" protein polyubiquitination|regulation of cell growth|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|early endosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|inflammatory response|Notch signaling pathway|membrane|protein ubiquitination|cytoplasmic vesicle|early endosome membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein-containing complex|protein K29-linked ubiquitination|ribonucleoprotein complex binding|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|ubiquitin-like protein ligase binding|innate immune response|CXCR chemokine receptor binding|positive regulation of protein catabolic process|negative regulation of JNK cascade|viral entry into host cell|negative regulation of defense response to virus|defense response to virus|protein autoubiquitination|ubiquitin protein ligase activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|protein K63-linked ubiquitination|protein K48-linked ubiquitination|regulation of protein deubiquitination|regulation of hematopoietic stem cell differentiation|arrestin family protein binding|positive regulation of receptor catabolic process "hsa04120,hsa04144,hsa04668,hsa04932" Ubiquitin mediated proteolysis|Endocytosis|TNF signaling pathway|Non-alcoholic fatty liver disease ITFG1 812.3000387 804.8600829 819.7399946 1.018487576 0.026428381 0.946019753 1 12.2892143 13.05556835 81533 integrin alpha FG-GAP repeat containing 1 "GO:0005886,GO:0016021,GO:0070062" plasma membrane|integral component of membrane|extracellular exosome ITFG2 426.5516984 466.8797455 386.2236513 0.827244392 -0.273614488 0.522326667 1 10.12235105 8.734361376 55846 integrin alpha FG-GAP repeat containing 2 "GO:0002314,GO:0005654,GO:0005765,GO:0005829,GO:0032006,GO:0034198,GO:0042149,GO:0140007,GO:1904262" germinal center B cell differentiation|nucleoplasm|lysosomal membrane|cytosol|regulation of TOR signaling|cellular response to amino acid starvation|cellular response to glucose starvation|KICSTOR complex|negative regulation of TORC1 signaling ITGA1 696.156366 644.4970399 747.8156922 1.160308963 0.214509013 0.571951946 1 3.040378299 3.679740569 3672 integrin subunit alpha 1 "GO:0000187,GO:0001669,GO:0005102,GO:0005515,GO:0005518,GO:0005886,GO:0005925,GO:0006936,GO:0007160,GO:0007229,GO:0008285,GO:0008305,GO:0009897,GO:0009986,GO:0016020,GO:0019903,GO:0030198,GO:0030593,GO:0032516,GO:0034665,GO:0042059,GO:0042311,GO:0043005,GO:0043204,GO:0043525,GO:0045121,GO:0045123,GO:0045178,GO:0046872,GO:0048812,GO:0070062,GO:0098639" activation of MAPK activity|acrosomal vesicle|signaling receptor binding|protein binding|collagen binding|plasma membrane|focal adhesion|muscle contraction|cell-matrix adhesion|integrin-mediated signaling pathway|negative regulation of cell population proliferation|integrin complex|external side of plasma membrane|cell surface|membrane|protein phosphatase binding|extracellular matrix organization|neutrophil chemotaxis|positive regulation of phosphoprotein phosphatase activity|integrin alpha1-beta1 complex|negative regulation of epidermal growth factor receptor signaling pathway|vasodilation|neuron projection|perikaryon|positive regulation of neuron apoptotic process|membrane raft|cellular extravasation|basal part of cell|metal ion binding|neuron projection morphogenesis|extracellular exosome|collagen binding involved in cell-matrix adhesion "hsa04151,hsa04510,hsa04512,hsa04640,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA10 17.4796597 16.23929549 18.72002391 1.15276084 0.205093232 0.908562417 1 0.152307968 0.183137706 8515 integrin subunit alpha 10 "GO:0005518,GO:0005886,GO:0007160,GO:0007229,GO:0008305,GO:0030198,GO:0034680,GO:0046872,GO:0098639" collagen binding|plasma membrane|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|extracellular matrix organization|integrin alpha10-beta1 complex|metal ion binding|collagen binding involved in cell-matrix adhesion "hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA11 209.3023784 264.9035077 153.701249 0.580215982 -0.785338059 0.139799696 1 1.229286068 0.743975402 22801 integrin subunit alpha 11 "GO:0001649,GO:0005518,GO:0005886,GO:0005925,GO:0006929,GO:0007155,GO:0007160,GO:0007229,GO:0007517,GO:0008305,GO:0016020,GO:0030198,GO:0033627,GO:0034681,GO:0038064,GO:0038065,GO:0046872,GO:0098639" osteoblast differentiation|collagen binding|plasma membrane|focal adhesion|substrate-dependent cell migration|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|integrin complex|membrane|extracellular matrix organization|cell adhesion mediated by integrin|integrin alpha11-beta1 complex|collagen receptor activity|collagen-activated signaling pathway|metal ion binding|collagen binding involved in cell-matrix adhesion "hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA2 2741.325048 2682.528624 2800.121472 1.043836568 0.061895848 0.846837033 1 17.3225311 18.86078596 3673 integrin subunit alpha 2 "GO:0001540,GO:0001618,GO:0001666,GO:0002687,GO:0005178,GO:0005515,GO:0005518,GO:0005634,GO:0005886,GO:0005925,GO:0006929,GO:0006971,GO:0007155,GO:0007160,GO:0007229,GO:0007565,GO:0007596,GO:0008283,GO:0008305,GO:0009887,GO:0009897,GO:0009986,GO:0010634,GO:0010694,GO:0014075,GO:0014850,GO:0014911,GO:0030198,GO:0030879,GO:0031346,GO:0031589,GO:0032967,GO:0033343,GO:0033591,GO:0033627,GO:0034666,GO:0038064,GO:0038065,GO:0042493,GO:0043236,GO:0043388,GO:0043395,GO:0043589,GO:0043679,GO:0044877,GO:0045178,GO:0045184,GO:0045727,GO:0045785,GO:0045987,GO:0046718,GO:0046872,GO:0048041,GO:0048333,GO:0048471,GO:0048661,GO:0050729,GO:0050927,GO:0050966,GO:0051971,GO:0060100,GO:0070365,GO:0071107,GO:0071260,GO:0071392,GO:0098639" "amyloid-beta binding|virus receptor activity|response to hypoxia|positive regulation of leukocyte migration|integrin binding|protein binding|collagen binding|nucleus|plasma membrane|focal adhesion|substrate-dependent cell migration|hypotonic response|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|female pregnancy|blood coagulation|cell population proliferation|integrin complex|animal organ morphogenesis|external side of plasma membrane|cell surface|positive regulation of epithelial cell migration|positive regulation of alkaline phosphatase activity|response to amine|response to muscle activity|positive regulation of smooth muscle cell migration|extracellular matrix organization|mammary gland development|positive regulation of cell projection organization|cell-substrate adhesion|positive regulation of collagen biosynthetic process|positive regulation of collagen binding|response to L-ascorbic acid|cell adhesion mediated by integrin|integrin alpha2-beta1 complex|collagen receptor activity|collagen-activated signaling pathway|response to drug|laminin binding|positive regulation of DNA binding|heparan sulfate proteoglycan binding|skin morphogenesis|axon terminus|protein-containing complex binding|basal part of cell|establishment of protein localization|positive regulation of translation|positive regulation of cell adhesion|positive regulation of smooth muscle contraction|viral entry into host cell|metal ion binding|focal adhesion assembly|mesodermal cell differentiation|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|positive regulation of inflammatory response|positive regulation of positive chemotaxis|detection of mechanical stimulus involved in sensory perception of pain|positive regulation of transmission of nerve impulse|positive regulation of phagocytosis, engulfment|hepatocyte differentiation|response to parathyroid hormone|cellular response to mechanical stimulus|cellular response to estradiol stimulus|collagen binding involved in cell-matrix adhesion" "hsa04145,hsa04151,hsa04510,hsa04512,hsa04611,hsa04640,hsa04810,hsa05165,hsa05200,hsa05205,hsa05222,hsa05410,hsa05412,hsa05414" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA2B 52.75346201 36.53841486 68.96850916 1.887561609 0.916523734 0.274177643 1 0.554885101 1.09249669 3674 integrin subunit alpha 2b "GO:0002576,GO:0002687,GO:0005515,GO:0005886,GO:0005925,GO:0007160,GO:0007229,GO:0008305,GO:0009897,GO:0009986,GO:0030198,GO:0031092,GO:0042802,GO:0045652,GO:0046872,GO:0050840,GO:0070051,GO:0070062,GO:0070527,GO:0072562" platelet degranulation|positive regulation of leukocyte migration|protein binding|plasma membrane|focal adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|external side of plasma membrane|cell surface|extracellular matrix organization|platelet alpha granule membrane|identical protein binding|regulation of megakaryocyte differentiation|metal ion binding|extracellular matrix binding|fibrinogen binding|extracellular exosome|platelet aggregation|blood microparticle "hsa04015,hsa04151,hsa04510,hsa04512,hsa04611,hsa04640,hsa04810,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414,hsa05418" Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Fluid shear stress and atherosclerosis ITGA3 25021.5466 29083.56327 20959.52993 0.720665819 -0.472597675 0.210415057 1 298.5366597 224.4127475 3675 integrin subunit alpha 3 "GO:0001764,GO:0001968,GO:0002020,GO:0005178,GO:0005515,GO:0005518,GO:0005886,GO:0005925,GO:0007160,GO:0007229,GO:0007507,GO:0007613,GO:0008305,GO:0009897,GO:0009986,GO:0010628,GO:0010634,GO:0010811,GO:0010976,GO:0016323,GO:0017015,GO:0019904,GO:0030111,GO:0030198,GO:0030324,GO:0030510,GO:0031345,GO:0031527,GO:0034667,GO:0034698,GO:0035024,GO:0035640,GO:0042493,GO:0043235,GO:0043236,GO:0043588,GO:0046872,GO:0046982,GO:0048333,GO:0048471,GO:0050900,GO:0060076,GO:0060135,GO:0070062,GO:0071438,GO:0071944,GO:0072006,GO:0097060,GO:0097062,GO:0097205,GO:1903078,GO:1990812" neuron migration|fibronectin binding|protease binding|integrin binding|protein binding|collagen binding|plasma membrane|focal adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|heart development|memory|integrin complex|external side of plasma membrane|cell surface|positive regulation of gene expression|positive regulation of epithelial cell migration|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|basolateral plasma membrane|regulation of transforming growth factor beta receptor signaling pathway|protein domain specific binding|regulation of Wnt signaling pathway|extracellular matrix organization|lung development|regulation of BMP signaling pathway|negative regulation of cell projection organization|filopodium membrane|integrin alpha3-beta1 complex|response to gonadotropin|negative regulation of Rho protein signal transduction|exploration behavior|response to drug|receptor complex|laminin binding|skin development|metal ion binding|protein heterodimerization activity|mesodermal cell differentiation|perinuclear region of cytoplasm|leukocyte migration|excitatory synapse|maternal process involved in female pregnancy|extracellular exosome|invadopodium membrane|cell periphery|nephron development|synaptic membrane|dendritic spine maintenance|renal filtration|positive regulation of protein localization to plasma membrane|growth cone filopodium "hsa04151,hsa04510,hsa04512,hsa04640,hsa04810,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA5 3626.125161 4301.383394 2950.866928 0.686027414 -0.543661866 0.088129285 1 50.43989223 36.09371216 3678 integrin subunit alpha 5 "GO:0001525,GO:0001618,GO:0001726,GO:0005154,GO:0005161,GO:0005178,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0005911,GO:0005925,GO:0007044,GO:0007155,GO:0007157,GO:0007159,GO:0007229,GO:0007565,GO:0007613,GO:0008305,GO:0009897,GO:0009986,GO:0010811,GO:0023035,GO:0030198,GO:0030335,GO:0030949,GO:0031410,GO:0031589,GO:0032587,GO:0033627,GO:0033631,GO:0034113,GO:0034674,GO:0035313,GO:0035987,GO:0043184,GO:0045202,GO:0046718,GO:0046872,GO:0050731,GO:0050900,GO:0071062,GO:1903672,GO:2000811" "angiogenesis|virus receptor activity|ruffle|epidermal growth factor receptor binding|platelet-derived growth factor receptor binding|integrin binding|protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|cell-cell junction|focal adhesion|cell-substrate junction assembly|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|leukocyte cell-cell adhesion|integrin-mediated signaling pathway|female pregnancy|memory|integrin complex|external side of plasma membrane|cell surface|positive regulation of cell-substrate adhesion|CD40 signaling pathway|extracellular matrix organization|positive regulation of cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|cytoplasmic vesicle|cell-substrate adhesion|ruffle membrane|cell adhesion mediated by integrin|cell-cell adhesion mediated by integrin|heterotypic cell-cell adhesion|integrin alpha5-beta1 complex|wound healing, spreading of epidermal cells|endodermal cell differentiation|vascular endothelial growth factor receptor 2 binding|synapse|viral entry into host cell|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|alphav-beta3 integrin-vitronectin complex|positive regulation of sprouting angiogenesis|negative regulation of anoikis" "hsa04145,hsa04151,hsa04510,hsa04512,hsa04640,hsa04810,hsa05100,hsa05131,hsa05133,hsa05135,hsa05165,hsa05168,hsa05205,hsa05206,hsa05410,hsa05412,hsa05414" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Pertussis|Yersinia infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Proteoglycans in cancer|MicroRNAs in cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA6 1837.160362 2198.394627 1475.926096 0.671365403 -0.5748299 0.076883611 1 18.48595922 12.94544185 3655 integrin subunit alpha 6 "GO:0005515,GO:0005886,GO:0005912,GO:0005925,GO:0007044,GO:0007229,GO:0009986,GO:0010668,GO:0010811,GO:0010976,GO:0030175,GO:0030198,GO:0030335,GO:0031581,GO:0031589,GO:0031994,GO:0034676,GO:0035878,GO:0038132,GO:0042327,GO:0043065,GO:0043236,GO:0043547,GO:0043589,GO:0044877,GO:0045296,GO:0045944,GO:0046872,GO:0050900,GO:0071407,GO:0098609,GO:2001237" protein binding|plasma membrane|adherens junction|focal adhesion|cell-substrate junction assembly|integrin-mediated signaling pathway|cell surface|ectodermal cell differentiation|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|filopodium|extracellular matrix organization|positive regulation of cell migration|hemidesmosome assembly|cell-substrate adhesion|insulin-like growth factor I binding|integrin alpha6-beta4 complex|nail development|neuregulin binding|positive regulation of phosphorylation|positive regulation of apoptotic process|laminin binding|positive regulation of GTPase activity|skin morphogenesis|protein-containing complex binding|cadherin binding|positive regulation of transcription by RNA polymerase II|metal ion binding|leukocyte migration|cellular response to organic cyclic compound|cell-cell adhesion|negative regulation of extrinsic apoptotic signaling pathway "hsa04151,hsa04510,hsa04512,hsa04514,hsa04640,hsa04810,hsa05145,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Toxoplasmosis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA7 494.7172979 243.5894324 745.8451633 3.061894582 1.614424613 0.000117417 0.018505451 2.614313503 8.349564617 3679 integrin subunit alpha 7 "GO:0005515,GO:0005886,GO:0007160,GO:0007229,GO:0007517,GO:0008305,GO:0008360,GO:0009986,GO:0030198,GO:0034113,GO:0035987,GO:0046872" protein binding|plasma membrane|cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|integrin complex|regulation of cell shape|cell surface|extracellular matrix organization|heterotypic cell-cell adhesion|endodermal cell differentiation|metal ion binding "hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGAE 346.5604504 353.204677 339.9162237 0.962377471 -0.055325225 0.908970507 1 3.114305512 3.126241988 3682 integrin subunit alpha E "GO:0005886,GO:0007155,GO:0007229,GO:0008305,GO:0009897,GO:0030198,GO:0046872" plasma membrane|cell adhesion|integrin-mediated signaling pathway|integrin complex|external side of plasma membrane|extracellular matrix organization|metal ion binding hsa04810 Regulation of actin cytoskeleton ITGAV 4087.622817 4597.750537 3577.495096 0.778096825 -0.361978401 0.256540265 1 32.26993415 26.19073294 3685 integrin subunit alpha V "GO:0001525,GO:0001570,GO:0001618,GO:0001846,GO:0001968,GO:0002020,GO:0002479,GO:0005080,GO:0005178,GO:0005245,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007160,GO:0007204,GO:0007229,GO:0008284,GO:0008305,GO:0009897,GO:0009986,GO:0010745,GO:0010888,GO:0015026,GO:0016020,GO:0017134,GO:0019960,GO:0030198,GO:0030335,GO:0031258,GO:0031527,GO:0031528,GO:0031589,GO:0031994,GO:0032369,GO:0032587,GO:0033627,GO:0033690,GO:0034113,GO:0034446,GO:0034683,GO:0034684,GO:0034685,GO:0034686,GO:0035579,GO:0035866,GO:0035867,GO:0035868,GO:0035987,GO:0038027,GO:0038132,GO:0043277,GO:0043312,GO:0045335,GO:0045785,GO:0046718,GO:0046872,GO:0048010,GO:0050431,GO:0050748,GO:0050764,GO:0050840,GO:0050900,GO:0050919,GO:0070062,GO:0070371,GO:0070588,GO:0071604,GO:0085017,GO:0097192,GO:1901388,GO:1905598,GO:1990430,GO:2000536,GO:2001237" "angiogenesis|vasculogenesis|virus receptor activity|opsonin binding|fibronectin binding|protease binding|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein kinase C binding|integrin binding|voltage-gated calcium channel activity|protein binding|cytosol|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|cell-matrix adhesion|positive regulation of cytosolic calcium ion concentration|integrin-mediated signaling pathway|positive regulation of cell population proliferation|integrin complex|external side of plasma membrane|cell surface|negative regulation of macrophage derived foam cell differentiation|negative regulation of lipid storage|coreceptor activity|membrane|fibroblast growth factor binding|C-X3-C chemokine binding|extracellular matrix organization|positive regulation of cell migration|lamellipodium membrane|filopodium membrane|microvillus membrane|cell-substrate adhesion|insulin-like growth factor I binding|negative regulation of lipid transport|ruffle membrane|cell adhesion mediated by integrin|positive regulation of osteoblast proliferation|heterotypic cell-cell adhesion|substrate adhesion-dependent cell spreading|integrin alphav-beta3 complex|integrin alphav-beta5 complex|integrin alphav-beta6 complex|integrin alphav-beta8 complex|specific granule membrane|alphav-beta3 integrin-PKCalpha complex|alphav-beta3 integrin-IGF-1-IGF1R complex|alphav-beta3 integrin-HMGB1 complex|endodermal cell differentiation|apolipoprotein A-I-mediated signaling pathway|neuregulin binding|apoptotic cell clearance|neutrophil degranulation|phagocytic vesicle|positive regulation of cell adhesion|viral entry into host cell|metal ion binding|vascular endothelial growth factor receptor signaling pathway|transforming growth factor beta binding|negative regulation of lipoprotein metabolic process|regulation of phagocytosis|extracellular matrix binding|leukocyte migration|negative chemotaxis|extracellular exosome|ERK1 and ERK2 cascade|calcium ion transmembrane transport|transforming growth factor beta production|entry into host cell by a symbiont-containing vacuole|extrinsic apoptotic signaling pathway in absence of ligand|regulation of transforming growth factor beta activation|negative regulation of low-density lipoprotein receptor activity|extracellular matrix protein binding|negative regulation of entry of bacterium into host cell|negative regulation of extrinsic apoptotic signaling pathway" "hsa04145,hsa04151,hsa04510,hsa04512,hsa04514,hsa04810,hsa04919,hsa05163,hsa05165,hsa05200,hsa05205,hsa05222,hsa05410,hsa05412,hsa05414,hsa05418" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Fluid shear stress and atherosclerosis ITGAX 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.030984894 0.020916079 3687 integrin subunit alpha X "GO:0005178,GO:0005515,GO:0005886,GO:0007155,GO:0007229,GO:0008284,GO:0008305,GO:0009887,GO:0009986,GO:0010628,GO:0016020,GO:0019221,GO:0030198,GO:0030335,GO:0030667,GO:0030971,GO:0031643,GO:0034113,GO:0034689,GO:0038023,GO:0043312,GO:0045766,GO:0046872,GO:0050900,GO:0070821,GO:0101003,GO:1905956" integrin binding|protein binding|plasma membrane|cell adhesion|integrin-mediated signaling pathway|positive regulation of cell population proliferation|integrin complex|animal organ morphogenesis|cell surface|positive regulation of gene expression|membrane|cytokine-mediated signaling pathway|extracellular matrix organization|positive regulation of cell migration|secretory granule membrane|receptor tyrosine kinase binding|positive regulation of myelination|heterotypic cell-cell adhesion|integrin alphaX-beta2 complex|signaling receptor activity|neutrophil degranulation|positive regulation of angiogenesis|metal ion binding|leukocyte migration|tertiary granule membrane|ficolin-1-rich granule membrane|positive regulation of endothelial tube morphogenesis "hsa04610,hsa04810,hsa05152" Complement and coagulation cascades|Regulation of actin cytoskeleton|Tuberculosis ITGB1 25934.8585 24838.00246 27031.71453 1.088320793 0.122103868 0.747328761 1 313.0025383 355.3208692 3688 integrin subunit beta 1 "GO:0000132,GO:0001618,GO:0001726,GO:0001968,GO:0002020,GO:0003779,GO:0005178,GO:0005515,GO:0005737,GO:0005886,GO:0005925,GO:0006909,GO:0006968,GO:0007155,GO:0007156,GO:0007159,GO:0007160,GO:0007161,GO:0007179,GO:0007229,GO:0008305,GO:0009986,GO:0010710,GO:0010763,GO:0015026,GO:0016020,GO:0016477,GO:0019221,GO:0019960,GO:0023035,GO:0030027,GO:0030030,GO:0030032,GO:0030175,GO:0030183,GO:0030198,GO:0030335,GO:0031589,GO:0031594,GO:0031623,GO:0032154,GO:0032587,GO:0033627,GO:0033631,GO:0034113,GO:0034665,GO:0034666,GO:0034667,GO:0034668,GO:0034674,GO:0034678,GO:0034680,GO:0034681,GO:0035633,GO:0042383,GO:0042470,GO:0043065,GO:0043149,GO:0043235,GO:0043236,GO:0043547,GO:0044877,GO:0045121,GO:0045296,GO:0045766,GO:0046718,GO:0046872,GO:0046982,GO:0048333,GO:0048471,GO:0050776,GO:0050839,GO:0050900,GO:0050901,GO:0051897,GO:0051951,GO:0055037,GO:0070062,GO:0071404,GO:0071438,GO:0090303,GO:0097386,GO:0098639,GO:0150003,GO:0150103,GO:1901979,GO:1903078,GO:1990782,GO:2000273,GO:2000811" establishment of mitotic spindle orientation|virus receptor activity|ruffle|fibronectin binding|protease binding|actin binding|integrin binding|protein binding|cytoplasm|plasma membrane|focal adhesion|phagocytosis|cellular defense response|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|leukocyte cell-cell adhesion|cell-matrix adhesion|calcium-independent cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|integrin complex|cell surface|regulation of collagen catabolic process|positive regulation of fibroblast migration|coreceptor activity|membrane|cell migration|cytokine-mediated signaling pathway|C-X3-C chemokine binding|CD40 signaling pathway|lamellipodium|cell projection organization|lamellipodium assembly|filopodium|B cell differentiation|extracellular matrix organization|positive regulation of cell migration|cell-substrate adhesion|neuromuscular junction|receptor internalization|cleavage furrow|ruffle membrane|cell adhesion mediated by integrin|cell-cell adhesion mediated by integrin|heterotypic cell-cell adhesion|integrin alpha1-beta1 complex|integrin alpha2-beta1 complex|integrin alpha3-beta1 complex|integrin alpha4-beta1 complex|integrin alpha5-beta1 complex|integrin alpha8-beta1 complex|integrin alpha10-beta1 complex|integrin alpha11-beta1 complex|maintenance of blood-brain barrier|sarcolemma|melanosome|positive regulation of apoptotic process|stress fiber assembly|receptor complex|laminin binding|positive regulation of GTPase activity|protein-containing complex binding|membrane raft|cadherin binding|positive regulation of angiogenesis|viral entry into host cell|metal ion binding|protein heterodimerization activity|mesodermal cell differentiation|perinuclear region of cytoplasm|regulation of immune response|cell adhesion molecule binding|leukocyte migration|leukocyte tethering or rolling|positive regulation of protein kinase B signaling|positive regulation of glutamate uptake involved in transmission of nerve impulse|recycling endosome|extracellular exosome|cellular response to low-density lipoprotein particle stimulus|invadopodium membrane|positive regulation of wound healing|glial cell projection|collagen binding involved in cell-matrix adhesion|regulation of spontaneous synaptic transmission|reactive gliosis|regulation of inward rectifier potassium channel activity|positive regulation of protein localization to plasma membrane|protein tyrosine kinase binding|positive regulation of signaling receptor activity|negative regulation of anoikis "hsa04015,hsa04145,hsa04151,hsa04360,hsa04510,hsa04512,hsa04514,hsa04530,hsa04611,hsa04670,hsa04810,hsa05100,hsa05130,hsa05131,hsa05133,hsa05135,hsa05140,hsa05145,hsa05165,hsa05200,hsa05205,hsa05222,hsa05410,hsa05412,hsa05414" Rap1 signaling pathway|Phagosome|PI3K-Akt signaling pathway|Axon guidance|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Pertussis|Yersinia infection|Leishmaniasis|Toxoplasmosis|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGB1BP1 921.8316519 951.0137424 892.6495614 0.938629508 -0.091372279 0.800626624 1 7.618711021 7.459189389 9270 integrin subunit beta 1 binding protein 1 "GO:0001726,GO:0002043,GO:0005092,GO:0005178,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0006469,GO:0006933,GO:0007160,GO:0007219,GO:0007229,GO:0008284,GO:0008285,GO:0010595,GO:0010764,GO:0016020,GO:0016477,GO:0016604,GO:0030027,GO:0030154,GO:0031214,GO:0032091,GO:0032148,GO:0033622,GO:0033628,GO:0034451,GO:0035148,GO:0035556,GO:0035924,GO:0043087,GO:0043113,GO:0044344,GO:0045747,GO:0045944,GO:0048471,GO:0051451,GO:0051496,GO:0051781,GO:0051895,GO:0051897,GO:0070373,GO:0071944,GO:0072659,GO:0090051,GO:0090314,GO:0090315,GO:0097746,GO:1900025,GO:2001044" ruffle|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|GDP-dissociation inhibitor activity|integrin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|negative regulation of protein kinase activity|negative regulation of cell adhesion involved in substrate-bound cell migration|cell-matrix adhesion|Notch signaling pathway|integrin-mediated signaling pathway|positive regulation of cell population proliferation|negative regulation of cell population proliferation|positive regulation of endothelial cell migration|negative regulation of fibroblast migration|membrane|cell migration|nuclear body|lamellipodium|cell differentiation|biomineral tissue development|negative regulation of protein binding|activation of protein kinase B activity|integrin activation|regulation of cell adhesion mediated by integrin|centriolar satellite|tube formation|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|regulation of GTPase activity|receptor clustering|cellular response to fibroblast growth factor stimulus|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|myoblast migration|positive regulation of stress fiber assembly|positive regulation of cell division|negative regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of ERK1 and ERK2 cascade|cell periphery|protein localization to plasma membrane|negative regulation of cell migration involved in sprouting angiogenesis|positive regulation of protein targeting to membrane|negative regulation of protein targeting to membrane|blood vessel diameter maintenance|negative regulation of substrate adhesion-dependent cell spreading|regulation of integrin-mediated signaling pathway ITGB1BP2 11.09028677 17.25425146 4.926322083 0.285513521 -1.808369028 0.192461091 1 0.682708568 0.203318999 26548 integrin subunit beta 1 binding protein 2 "GO:0005178,GO:0005509,GO:0005515,GO:0007165,GO:0007517,GO:0008270,GO:0017124,GO:0030018" integrin binding|calcium ion binding|protein binding|signal transduction|muscle organ development|zinc ion binding|SH3 domain binding|Z disc ITGB2 16.7319277 32.47859099 0.985264417 0.030335812 -5.042834281 0.001546793 0.121890884 0.523695019 0.016571049 3689 integrin subunit beta 2 "GO:0001540,GO:0001774,GO:0001851,GO:0002523,GO:0005178,GO:0005515,GO:0005886,GO:0005925,GO:0006898,GO:0006911,GO:0006915,GO:0006954,GO:0007155,GO:0007159,GO:0007160,GO:0007229,GO:0007267,GO:0007568,GO:0008305,GO:0008360,GO:0009897,GO:0009986,GO:0016020,GO:0016477,GO:0019221,GO:0019901,GO:0030101,GO:0030198,GO:0030369,GO:0030593,GO:0031072,GO:0031623,GO:0032930,GO:0033627,GO:0034113,GO:0034142,GO:0034687,GO:0034688,GO:0034689,GO:0035579,GO:0035987,GO:0038024,GO:0043113,GO:0043235,GO:0043312,GO:0043315,GO:0043542,GO:0044853,GO:0045123,GO:0045429,GO:0045766,GO:0045963,GO:0046872,GO:0050730,GO:0050776,GO:0050839,GO:0050900,GO:0051092,GO:0070062,GO:0070821,GO:0071404,GO:0090314,GO:0097242,GO:0098609,GO:0098742,GO:0099568,GO:0101003,GO:1901216,GO:1903561,GO:1904996,GO:1990266,GO:2000363" "amyloid-beta binding|microglial cell activation|complement component C3b binding|leukocyte migration involved in inflammatory response|integrin binding|protein binding|plasma membrane|focal adhesion|receptor-mediated endocytosis|phagocytosis, engulfment|apoptotic process|inflammatory response|cell adhesion|leukocyte cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|cell-cell signaling|aging|integrin complex|regulation of cell shape|external side of plasma membrane|cell surface|membrane|cell migration|cytokine-mediated signaling pathway|protein kinase binding|natural killer cell activation|extracellular matrix organization|ICAM-3 receptor activity|neutrophil chemotaxis|heat shock protein binding|receptor internalization|positive regulation of superoxide anion generation|cell adhesion mediated by integrin|heterotypic cell-cell adhesion|toll-like receptor 4 signaling pathway|integrin alphaL-beta2 complex|integrin alphaM-beta2 complex|integrin alphaX-beta2 complex|specific granule membrane|endodermal cell differentiation|cargo receptor activity|receptor clustering|receptor complex|neutrophil degranulation|positive regulation of neutrophil degranulation|endothelial cell migration|plasma membrane raft|cellular extravasation|positive regulation of nitric oxide biosynthetic process|positive regulation of angiogenesis|negative regulation of dopamine metabolic process|metal ion binding|regulation of peptidyl-tyrosine phosphorylation|regulation of immune response|cell adhesion molecule binding|leukocyte migration|positive regulation of NF-kappaB transcription factor activity|extracellular exosome|tertiary granule membrane|cellular response to low-density lipoprotein particle stimulus|positive regulation of protein targeting to membrane|amyloid-beta clearance|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules|cytoplasmic region|ficolin-1-rich granule membrane|positive regulation of neuron death|extracellular vesicle|positive regulation of leukocyte adhesion to vascular endothelial cell|neutrophil migration|positive regulation of prostaglandin-E synthase activity" "hsa04015,hsa04145,hsa04390,hsa04514,hsa04610,hsa04650,hsa04670,hsa04810,hsa05133,hsa05134,hsa05140,hsa05144,hsa05146,hsa05150,hsa05152,hsa05166,hsa05323,hsa05416" Rap1 signaling pathway|Phagosome|Hippo signaling pathway|Cell adhesion molecules|Complement and coagulation cascades|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Pertussis|Legionellosis|Leishmaniasis|Malaria|Amoebiasis|Staphylococcus aureus infection|Tuberculosis|Human T-cell leukemia virus 1 infection|Rheumatoid arthritis|Viral myocarditis ITGB3 3110.370914 5381.296544 839.4452829 0.155993128 -2.680445616 2.62E-15 8.87E-12 45.87505233 7.464452698 3690 integrin subunit beta 3 "GO:0001618,GO:0001934,GO:0001938,GO:0001968,GO:0002020,GO:0002576,GO:0003756,GO:0005161,GO:0005178,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0007155,GO:0007160,GO:0007229,GO:0007596,GO:0008305,GO:0009986,GO:0010595,GO:0010745,GO:0010888,GO:0014909,GO:0015026,GO:0016477,GO:0017134,GO:0018215,GO:0019899,GO:0019960,GO:0030168,GO:0030198,GO:0030949,GO:0031092,GO:0031258,GO:0031527,GO:0031528,GO:0031589,GO:0031994,GO:0032147,GO:0032369,GO:0032587,GO:0032880,GO:0032991,GO:0033627,GO:0034113,GO:0034446,GO:0034683,GO:0035295,GO:0035866,GO:0035867,GO:0035868,GO:0038027,GO:0038132,GO:0042060,GO:0042470,GO:0042802,GO:0043184,GO:0043235,GO:0043277,GO:0045124,GO:0045202,GO:0045211,GO:0046718,GO:0048010,GO:0048333,GO:0050731,GO:0050748,GO:0050839,GO:0050840,GO:0050900,GO:0050919,GO:0051611,GO:0060055,GO:0070051,GO:0070062,GO:0070527,GO:0071062,GO:0098978,GO:0099149,GO:1905598" virus receptor activity|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|fibronectin binding|protease binding|platelet degranulation|protein disulfide isomerase activity|platelet-derived growth factor receptor binding|integrin binding|protein binding|nucleus|nucleoplasm|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|blood coagulation|integrin complex|cell surface|positive regulation of endothelial cell migration|negative regulation of macrophage derived foam cell differentiation|negative regulation of lipid storage|smooth muscle cell migration|coreceptor activity|cell migration|fibroblast growth factor binding|protein phosphopantetheinylation|enzyme binding|C-X3-C chemokine binding|platelet activation|extracellular matrix organization|positive regulation of vascular endothelial growth factor receptor signaling pathway|platelet alpha granule membrane|lamellipodium membrane|filopodium membrane|microvillus membrane|cell-substrate adhesion|insulin-like growth factor I binding|activation of protein kinase activity|negative regulation of lipid transport|ruffle membrane|regulation of protein localization|protein-containing complex|cell adhesion mediated by integrin|heterotypic cell-cell adhesion|substrate adhesion-dependent cell spreading|integrin alphav-beta3 complex|tube development|alphav-beta3 integrin-PKCalpha complex|alphav-beta3 integrin-IGF-1-IGF1R complex|alphav-beta3 integrin-HMGB1 complex|apolipoprotein A-I-mediated signaling pathway|neuregulin binding|wound healing|melanosome|identical protein binding|vascular endothelial growth factor receptor 2 binding|receptor complex|apoptotic cell clearance|regulation of bone resorption|synapse|postsynaptic membrane|viral entry into host cell|vascular endothelial growth factor receptor signaling pathway|mesodermal cell differentiation|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of lipoprotein metabolic process|cell adhesion molecule binding|extracellular matrix binding|leukocyte migration|negative chemotaxis|regulation of serotonin uptake|angiogenesis involved in wound healing|fibrinogen binding|extracellular exosome|platelet aggregation|alphav-beta3 integrin-vitronectin complex|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|negative regulation of low-density lipoprotein receptor activity "hsa04015,hsa04145,hsa04151,hsa04380,hsa04510,hsa04512,hsa04611,hsa04640,hsa04810,hsa04919,hsa05163,hsa05165,hsa05168,hsa05205,hsa05206,hsa05410,hsa05412,hsa05414,hsa05418" Rap1 signaling pathway|Phagosome|PI3K-Akt signaling pathway|Osteoclast differentiation|Focal adhesion|ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Proteoglycans in cancer|MicroRNAs in cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Fluid shear stress and atherosclerosis ITGB3BP 382.3565764 375.5337083 389.1794445 1.036336914 0.051493101 0.912643146 1 5.179590828 5.599024282 23421 integrin subunit beta 3 binding protein "GO:0000777,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006915,GO:0007049,GO:0007155,GO:0007165,GO:0008022,GO:0016020,GO:0034080,GO:0043065,GO:0051301" "condensed chromosome kinetochore|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|apoptotic process|cell cycle|cell adhesion|signal transduction|protein C-terminus binding|membrane|CENP-A containing nucleosome assembly|positive regulation of apoptotic process|cell division" ITGB4 88.80196627 76.12169763 101.4822349 1.3331578 0.414847555 0.562418936 1 0.561914509 0.781389792 3691 integrin subunit beta 4 "GO:0001664,GO:0005178,GO:0005515,GO:0005604,GO:0005730,GO:0005886,GO:0005925,GO:0006914,GO:0007155,GO:0007160,GO:0007229,GO:0008305,GO:0009611,GO:0009925,GO:0009986,GO:0016477,GO:0030054,GO:0030056,GO:0030198,GO:0031252,GO:0031581,GO:0031965,GO:0031994,GO:0032290,GO:0033627,GO:0035878,GO:0038132,GO:0043235,GO:0043589,GO:0046847,GO:0048333,GO:0048870,GO:0061450,GO:0070062" G protein-coupled receptor binding|integrin binding|protein binding|basement membrane|nucleolus|plasma membrane|focal adhesion|autophagy|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|response to wounding|basal plasma membrane|cell surface|cell migration|cell junction|hemidesmosome|extracellular matrix organization|cell leading edge|hemidesmosome assembly|nuclear membrane|insulin-like growth factor I binding|peripheral nervous system myelin formation|cell adhesion mediated by integrin|nail development|neuregulin binding|receptor complex|skin morphogenesis|filopodium assembly|mesodermal cell differentiation|cell motility|trophoblast cell migration|extracellular exosome "hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGB5 2046.386036 2121.257974 1971.514098 0.929407984 -0.105616056 0.743654017 1 24.03988208 23.30529807 3693 integrin subunit beta 5 "GO:0001618,GO:0002479,GO:0005178,GO:0005515,GO:0005886,GO:0005925,GO:0006936,GO:0007160,GO:0007179,GO:0007229,GO:0008305,GO:0009986,GO:0016477,GO:0030198,GO:0033627,GO:0034684,GO:0035987,GO:0038023,GO:0043149,GO:0043235,GO:0045335,GO:0046718,GO:0070062,GO:0090136" "virus receptor activity|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|integrin binding|protein binding|plasma membrane|focal adhesion|muscle contraction|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|integrin complex|cell surface|cell migration|extracellular matrix organization|cell adhesion mediated by integrin|integrin alphav-beta5 complex|endodermal cell differentiation|signaling receptor activity|stress fiber assembly|receptor complex|phagocytic vesicle|viral entry into host cell|extracellular exosome|epithelial cell-cell adhesion" "hsa04145,hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05205,hsa05410,hsa05412,hsa05414" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Proteoglycans in cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGB6 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.044304192 0.022430366 3694 integrin subunit beta 6 "GO:0000902,GO:0001618,GO:0005178,GO:0005515,GO:0005654,GO:0005813,GO:0005886,GO:0005925,GO:0006954,GO:0006955,GO:0007155,GO:0007160,GO:0007179,GO:0007229,GO:0008305,GO:0009615,GO:0009897,GO:0009986,GO:0016477,GO:0030054,GO:0030198,GO:0033627,GO:0034685,GO:0038023,GO:0043129,GO:0043235,GO:0043588,GO:0046718,GO:0048286,GO:0055091,GO:0060022,GO:0060348,GO:0060395,GO:0060435,GO:0061520,GO:0070166,GO:0071479,GO:0071604,GO:1901388" cell morphogenesis|virus receptor activity|integrin binding|protein binding|nucleoplasm|centrosome|plasma membrane|focal adhesion|inflammatory response|immune response|cell adhesion|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|integrin complex|response to virus|external side of plasma membrane|cell surface|cell migration|cell junction|extracellular matrix organization|cell adhesion mediated by integrin|integrin alphav-beta6 complex|signaling receptor activity|surfactant homeostasis|receptor complex|skin development|viral entry into host cell|lung alveolus development|phospholipid homeostasis|hard palate development|bone development|SMAD protein signal transduction|bronchiole development|Langerhans cell differentiation|enamel mineralization|cellular response to ionizing radiation|transforming growth factor beta production|regulation of transforming growth factor beta activation "hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGB8 2252.647506 2515.06089 1990.234121 0.791326417 -0.337655176 0.291599691 1 12.41994554 10.25159133 3696 integrin subunit beta 8 "GO:0001570,GO:0001573,GO:0005178,GO:0005886,GO:0005925,GO:0006955,GO:0007155,GO:0007160,GO:0007179,GO:0007229,GO:0008305,GO:0009615,GO:0009986,GO:0010628,GO:0010629,GO:0016477,GO:0030198,GO:0033627,GO:0034686,GO:0038023,GO:0045766,GO:0051216,GO:0060022,GO:0060674,GO:0061520,GO:0070062,GO:1901388,GO:1990430" vasculogenesis|ganglioside metabolic process|integrin binding|plasma membrane|focal adhesion|immune response|cell adhesion|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|integrin complex|response to virus|cell surface|positive regulation of gene expression|negative regulation of gene expression|cell migration|extracellular matrix organization|cell adhesion mediated by integrin|integrin alphav-beta8 complex|signaling receptor activity|positive regulation of angiogenesis|cartilage development|hard palate development|placenta blood vessel development|Langerhans cell differentiation|extracellular exosome|regulation of transforming growth factor beta activation|extracellular matrix protein binding "hsa04151,hsa04510,hsa04512,hsa04514,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGBL1 9.04552906 12.17947162 5.911586499 0.485372985 -1.042834281 0.499104294 1 0.103916319 0.052610846 9358 integrin subunit beta like 1 "GO:0005178,GO:0005576,GO:0005886,GO:0005925,GO:0007155,GO:0007160,GO:0007229,GO:0008305,GO:0009986,GO:0016477,GO:0033627" integrin binding|extracellular region|plasma membrane|focal adhesion|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|cell surface|cell migration|cell adhesion mediated by integrin ITIH4 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.109636677 0.063436519 3700 inter-alpha-trypsin inhibitor heavy chain 4 "GO:0002576,GO:0004866,GO:0004867,GO:0005515,GO:0005576,GO:0006953,GO:0010951,GO:0030212,GO:0031089,GO:0034097,GO:0062023,GO:0070062,GO:0072562" platelet degranulation|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|acute-phase response|negative regulation of endopeptidase activity|hyaluronan metabolic process|platelet dense granule lumen|response to cytokine|collagen-containing extracellular matrix|extracellular exosome|blood microparticle ITM2B 3376.5462 3303.681677 3449.410722 1.044111104 0.062275237 0.845514363 1 16.58438123 18.06183692 9445 integral membrane protein 2B "GO:0000139,GO:0001540,GO:0005515,GO:0005524,GO:0005576,GO:0005615,GO:0005794,GO:0005886,GO:0007399,GO:0010008,GO:0016020,GO:0030660,GO:0031301,GO:0042985,GO:0043231,GO:0044267,GO:0070062" Golgi membrane|amyloid-beta binding|protein binding|ATP binding|extracellular region|extracellular space|Golgi apparatus|plasma membrane|nervous system development|endosome membrane|membrane|Golgi-associated vesicle membrane|integral component of organelle membrane|negative regulation of amyloid precursor protein biosynthetic process|intracellular membrane-bounded organelle|cellular protein metabolic process|extracellular exosome ITM2C 6849.930382 6626.647518 7073.213246 1.067389389 0.094086575 0.773834507 1 126.9830947 141.378939 81618 integral membrane protein 2C "GO:0001540,GO:0005515,GO:0005524,GO:0005764,GO:0005765,GO:0005794,GO:0005886,GO:0010977,GO:0016021,GO:0030182,GO:0042985,GO:0048471,GO:0070062,GO:2001238" amyloid-beta binding|protein binding|ATP binding|lysosome|lysosomal membrane|Golgi apparatus|plasma membrane|negative regulation of neuron projection development|integral component of membrane|neuron differentiation|negative regulation of amyloid precursor protein biosynthetic process|perinuclear region of cytoplasm|extracellular exosome|positive regulation of extrinsic apoptotic signaling pathway ITPA 1051.549061 1062.658899 1040.439224 0.979090492 -0.030485889 0.933260837 1 18.07250651 18.45683172 3704 inosine triphosphatase "GO:0000166,GO:0005654,GO:0005737,GO:0005829,GO:0006193,GO:0006195,GO:0009143,GO:0009204,GO:0035529,GO:0035870,GO:0036218,GO:0042802,GO:0043231,GO:0046872,GO:0047429,GO:0051276" nucleotide binding|nucleoplasm|cytoplasm|cytosol|ITP catabolic process|purine nucleotide catabolic process|nucleoside triphosphate catabolic process|deoxyribonucleoside triphosphate catabolic process|NADH pyrophosphatase activity|dITP diphosphatase activity|dTTP diphosphatase activity|identical protein binding|intracellular membrane-bounded organelle|metal ion binding|nucleoside-triphosphate diphosphatase activity|chromosome organization "hsa00230,hsa00983" Purine metabolism|Drug metabolism - other enzymes ITPK1 1461.69148 1384.399941 1538.983019 1.111660708 0.152716528 0.647075384 1 10.7209439 12.43143344 3705 inositol-tetrakisphosphate 1-kinase "GO:0000287,GO:0000825,GO:0003824,GO:0005524,GO:0005737,GO:0005829,GO:0007165,GO:0007596,GO:0016324,GO:0016787,GO:0016853,GO:0021915,GO:0032957,GO:0043647,GO:0047325,GO:0052725,GO:0052726,GO:0052746,GO:0070266" "magnesium ion binding|inositol tetrakisphosphate 6-kinase activity|catalytic activity|ATP binding|cytoplasm|cytosol|signal transduction|blood coagulation|apical plasma membrane|hydrolase activity|isomerase activity|neural tube development|inositol trisphosphate metabolic process|inositol phosphate metabolic process|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 6-kinase activity|inositol-1,3,4-trisphosphate 5-kinase activity|inositol phosphorylation|necroptotic process" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system ITPKA 64.91808785 59.88240213 69.95377357 1.168185829 0.224269789 0.789229199 1 1.508871849 1.838570211 3706 inositol-trisphosphate 3-kinase A "GO:0000828,GO:0004683,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006020,GO:0006468,GO:0007165,GO:0008440,GO:0016301,GO:0030036,GO:0031267,GO:0032958,GO:0043197,GO:0043647,GO:0046854,GO:0048167,GO:0061003,GO:0097062" "inositol hexakisphosphate kinase activity|calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|inositol metabolic process|protein phosphorylation|signal transduction|inositol-1,4,5-trisphosphate 3-kinase activity|kinase activity|actin cytoskeleton organization|small GTPase binding|inositol phosphate biosynthetic process|dendritic spine|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|regulation of synaptic plasticity|positive regulation of dendritic spine morphogenesis|dendritic spine maintenance" "hsa00562,hsa04020,hsa04070" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system ITPKB 570.0385614 509.5078961 630.5692266 1.237604425 0.30755026 0.437872206 1 1.756502451 2.267496071 3707 inositol-trisphosphate 3-kinase B "GO:0000165,GO:0000828,GO:0001932,GO:0002262,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0007165,GO:0007166,GO:0008440,GO:0016020,GO:0016301,GO:0032957,GO:0032958,GO:0033030,GO:0035726,GO:0043647,GO:0045059,GO:0045638,GO:0046579,GO:0046638,GO:0046854,GO:0071277" "MAPK cascade|inositol hexakisphosphate kinase activity|regulation of protein phosphorylation|myeloid cell homeostasis|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|signal transduction|cell surface receptor signaling pathway|inositol-1,4,5-trisphosphate 3-kinase activity|membrane|kinase activity|inositol trisphosphate metabolic process|inositol phosphate biosynthetic process|negative regulation of neutrophil apoptotic process|common myeloid progenitor cell proliferation|inositol phosphate metabolic process|positive thymic T cell selection|negative regulation of myeloid cell differentiation|positive regulation of Ras protein signal transduction|positive regulation of alpha-beta T cell differentiation|phosphatidylinositol phosphorylation|cellular response to calcium ion" "hsa00562,hsa04020,hsa04070" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system ITPKC 251.971107 218.2155332 285.7266808 1.309378286 0.388881959 0.438401489 1 3.217422689 4.394294753 80271 inositol-trisphosphate 3-kinase C "GO:0000828,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0008440,GO:0016301,GO:0016607,GO:0032958,GO:0043647,GO:0046854" "inositol hexakisphosphate kinase activity|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|inositol-1,4,5-trisphosphate 3-kinase activity|kinase activity|nuclear speck|inositol phosphate biosynthetic process|inositol phosphate metabolic process|phosphatidylinositol phosphorylation" "hsa00562,hsa04020,hsa04070" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system ITPR1 286.1393948 432.3712425 139.9075471 0.32358199 -1.627796782 0.000905193 0.085201333 1.834470815 0.619171672 3708 "inositol 1,4,5-trisphosphate receptor type 1" "GO:0001666,GO:0005220,GO:0005509,GO:0005515,GO:0005637,GO:0005730,GO:0005783,GO:0005789,GO:0005886,GO:0005955,GO:0006816,GO:0007165,GO:0009791,GO:0010506,GO:0014069,GO:0015085,GO:0015278,GO:0016020,GO:0016021,GO:0016529,GO:0019855,GO:0030168,GO:0030658,GO:0030659,GO:0030667,GO:0031088,GO:0031094,GO:0031095,GO:0032469,GO:0035091,GO:0042045,GO:0048016,GO:0048471,GO:0050796,GO:0050849,GO:0050882,GO:0051209,GO:0070059,GO:0070679,GO:0098685,GO:0098695,GO:0099566,GO:1903779" "response to hypoxia|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion binding|protein binding|nuclear inner membrane|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|calcineurin complex|calcium ion transport|signal transduction|post-embryonic development|regulation of autophagy|postsynaptic density|calcium ion transmembrane transporter activity|calcium-release channel activity|membrane|integral component of membrane|sarcoplasmic reticulum|calcium channel inhibitor activity|platelet activation|transport vesicle membrane|cytoplasmic vesicle membrane|secretory granule membrane|platelet dense granule membrane|platelet dense tubular network|platelet dense tubular network membrane|endoplasmic reticulum calcium ion homeostasis|phosphatidylinositol binding|epithelial fluid transport|inositol phosphate-mediated signaling|perinuclear region of cytoplasm|regulation of insulin secretion|negative regulation of calcium-mediated signaling|voluntary musculoskeletal movement|release of sequestered calcium ion into cytosol|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|inositol 1,4,5 trisphosphate binding|Schaffer collateral - CA1 synapse|inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels|regulation of postsynaptic cytosolic calcium ion concentration|regulation of cardiac conduction" "hsa04020,hsa04022,hsa04070,hsa04114,hsa04140,hsa04210,hsa04218,hsa04270,hsa04371,hsa04540,hsa04611,hsa04621,hsa04625,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04912,hsa04915,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04929,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05131,hsa05163,hsa05167,hsa05170,hsa05205" "Calcium signaling pathway|cGMP-PKG signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Autophagy - animal|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer" ITPR2 1429.264107 1423.983224 1434.54499 1.007417058 0.010661065 0.976827682 1 5.426207717 5.701926895 3709 "inositol 1,4,5-trisphosphate receptor type 2" "GO:0001666,GO:0005220,GO:0005509,GO:0005654,GO:0005783,GO:0005789,GO:0005886,GO:0005938,GO:0007165,GO:0015085,GO:0016020,GO:0016021,GO:0016529,GO:0030168,GO:0030659,GO:0030667,GO:0031095,GO:0033017,GO:0035091,GO:0043235,GO:0044325,GO:0048016,GO:0050796,GO:0051209,GO:0070679,GO:0071320,GO:0071361,GO:0097110,GO:1903779" "response to hypoxia|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cell cortex|signal transduction|calcium ion transmembrane transporter activity|membrane|integral component of membrane|sarcoplasmic reticulum|platelet activation|cytoplasmic vesicle membrane|secretory granule membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane|phosphatidylinositol binding|receptor complex|ion channel binding|inositol phosphate-mediated signaling|regulation of insulin secretion|release of sequestered calcium ion into cytosol|inositol 1,4,5 trisphosphate binding|cellular response to cAMP|cellular response to ethanol|scaffold protein binding|regulation of cardiac conduction" "hsa04020,hsa04022,hsa04070,hsa04114,hsa04210,hsa04218,hsa04270,hsa04371,hsa04540,hsa04611,hsa04621,hsa04625,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04912,hsa04915,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04929,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa05010,hsa05012,hsa05017,hsa05020,hsa05022,hsa05131,hsa05163,hsa05167,hsa05170,hsa05205" "Calcium signaling pathway|cGMP-PKG signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Parkinson disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer" ITPR3 9740.955254 10786.95203 8694.958476 0.806062588 -0.311036231 0.354403962 1 60.01549669 50.46009911 3710 "inositol 1,4,5-trisphosphate receptor type 3" "GO:0000822,GO:0005220,GO:0005509,GO:0005515,GO:0005640,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0005903,GO:0007186,GO:0007204,GO:0007613,GO:0015278,GO:0016020,GO:0016529,GO:0030168,GO:0030659,GO:0030667,GO:0031095,GO:0035091,GO:0043025,GO:0043209,GO:0043235,GO:0043533,GO:0045177,GO:0048016,GO:0050796,GO:0050913,GO:0050916,GO:0050917,GO:0051209,GO:0051592,GO:0060291,GO:0060402,GO:0070679,GO:1903779" "inositol hexakisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion binding|protein binding|nuclear outer membrane|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|brush border|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|memory|calcium-release channel activity|membrane|sarcoplasmic reticulum|platelet activation|cytoplasmic vesicle membrane|secretory granule membrane|platelet dense tubular network membrane|phosphatidylinositol binding|neuronal cell body|myelin sheath|receptor complex|inositol 1,3,4,5 tetrakisphosphate binding|apical part of cell|inositol phosphate-mediated signaling|regulation of insulin secretion|sensory perception of bitter taste|sensory perception of sweet taste|sensory perception of umami taste|release of sequestered calcium ion into cytosol|response to calcium ion|long-term synaptic potentiation|calcium ion transport into cytosol|inositol 1,4,5 trisphosphate binding|regulation of cardiac conduction" "hsa04020,hsa04022,hsa04070,hsa04114,hsa04210,hsa04218,hsa04270,hsa04371,hsa04540,hsa04611,hsa04621,hsa04625,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04929,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa05010,hsa05012,hsa05014,hsa05017,hsa05020,hsa05022,hsa05131,hsa05163,hsa05167,hsa05170,hsa05205" "Calcium signaling pathway|cGMP-PKG signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer" ITPRID2 3139.649737 2937.282572 3342.016901 1.137792098 0.186236967 0.55844687 1 20.89955046 24.80366104 6744 ITPR interacting domain containing 2 "GO:0005102,GO:0005654,GO:0005829,GO:0005886,GO:0051015" signaling receptor binding|nucleoplasm|cytosol|plasma membrane|actin filament binding ITPRIP 1597.624072 1617.839814 1577.408331 0.97500897 -0.036512603 0.913507765 1 11.44863479 11.64335777 85450 "inositol 1,4,5-trisphosphate receptor interacting protein" "GO:0004860,GO:0005515,GO:0005640,GO:0005886,GO:0006469,GO:0016020,GO:0016021,GO:1902042" protein kinase inhibitor activity|protein binding|nuclear outer membrane|plasma membrane|negative regulation of protein kinase activity|membrane|integral component of membrane|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ITPRIPL2 1140.623695 1090.06271 1191.18468 1.092767112 0.12798597 0.711989691 1 7.201647633 8.208719465 162073 ITPRIP like 2 GO:0016021 integral component of membrane ITSN1 1469.942018 1443.267387 1496.616649 1.036964226 0.052366124 0.876669275 1 3.724657407 4.028710276 6453 intersectin 1 "GO:0005085,GO:0005509,GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0005886,GO:0005905,GO:0006887,GO:0006897,GO:0007186,GO:0007420,GO:0015031,GO:0016032,GO:0016197,GO:0030027,GO:0034613,GO:0035556,GO:0042734,GO:0043025,GO:0043065,GO:0043197,GO:0048013,GO:0050790,GO:0051056,GO:0055037,GO:0060090,GO:0060124,GO:0060999,GO:0061024,GO:0070064,GO:0097440,GO:0097708,GO:0098793,GO:0098871,GO:0098978,GO:0150007,GO:1905274,GO:2001288" guanyl-nucleotide exchange factor activity|calcium ion binding|protein binding|nuclear envelope|cytoplasm|cytosol|plasma membrane|clathrin-coated pit|exocytosis|endocytosis|G protein-coupled receptor signaling pathway|brain development|protein transport|viral process|endosomal transport|lamellipodium|cellular protein localization|intracellular signal transduction|presynaptic membrane|neuronal cell body|positive regulation of apoptotic process|dendritic spine|ephrin receptor signaling pathway|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|recycling endosome|molecular adaptor activity|positive regulation of growth hormone secretion|positive regulation of dendritic spine development|membrane organization|proline-rich region binding|apical dendrite|intracellular vesicle|presynapse|postsynaptic actin cytoskeleton|glutamatergic synapse|clathrin-dependent synaptic vesicle endocytosis|regulation of modification of postsynaptic actin cytoskeleton|positive regulation of caveolin-mediated endocytosis ITSN2 750.8303763 744.9776808 756.6830719 1.015712405 0.022491967 0.95564494 1 3.298119878 3.494243158 50618 intersectin 2 "GO:0005085,GO:0005509,GO:0005515,GO:0005737,GO:0005813,GO:0005886,GO:0005905,GO:0006897,GO:0016032,GO:0016197,GO:0030154,GO:0042734,GO:0050790,GO:0060090,GO:0070062,GO:0097708,GO:0098793,GO:0150007,GO:1903861" guanyl-nucleotide exchange factor activity|calcium ion binding|protein binding|cytoplasm|centrosome|plasma membrane|clathrin-coated pit|endocytosis|viral process|endosomal transport|cell differentiation|presynaptic membrane|regulation of catalytic activity|molecular adaptor activity|extracellular exosome|intracellular vesicle|presynapse|clathrin-dependent synaptic vesicle endocytosis|positive regulation of dendrite extension IVD 1263.575144 1244.336017 1282.81427 1.030922719 0.043936188 0.899229924 1 11.20576627 12.04990436 3712 isovaleryl-CoA dehydrogenase "GO:0004085,GO:0005515,GO:0005759,GO:0006552,GO:0008470,GO:0009083,GO:0031966,GO:0033539,GO:0042802,GO:0050660" butyryl-CoA dehydrogenase activity|protein binding|mitochondrial matrix|leucine catabolic process|isovaleryl-CoA dehydrogenase activity|branched-chain amino acid catabolic process|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|identical protein binding|flavin adenine dinucleotide binding hsa00280 "Valine, leucine and isoleucine degradation" IVNS1ABP 1881.908983 2091.824251 1671.993715 0.799299327 -0.323192221 0.318277248 1 12.7704338 10.64709249 10625 influenza virus NS1A binding protein "GO:0005515,GO:0005654,GO:0005667,GO:0005681,GO:0005829,GO:0005856,GO:0006383,GO:0008380,GO:0009615,GO:0016032,GO:0031397,GO:2001243" protein binding|nucleoplasm|transcription regulator complex|spliceosomal complex|cytosol|cytoskeleton|transcription by RNA polymerase III|RNA splicing|response to virus|viral process|negative regulation of protein ubiquitination|negative regulation of intrinsic apoptotic signaling pathway IWS1 1000.380138 999.7316288 1001.028647 1.001297367 0.001870491 0.999027072 1 12.49885958 13.05417386 55677 "interacts with SUPT6H, CTD assembly factor 1" "GO:0005515,GO:0005634,GO:0005654,GO:0006366,GO:0006368,GO:0006397,GO:0008380,GO:0010793,GO:0016973,GO:0050684,GO:0051028,GO:0090239,GO:2001253" protein binding|nucleus|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA processing|RNA splicing|regulation of mRNA export from nucleus|poly(A)+ mRNA export from nucleus|regulation of mRNA processing|mRNA transport|regulation of histone H4 acetylation|regulation of histone H3-K36 trimethylation IZUMO4 17.06125638 21.31407534 12.80843742 0.600937982 -0.734711986 0.54859698 1 0.884097235 0.554173324 113177 IZUMO family member 4 "GO:0005576,GO:0005634" extracellular region|nucleus JADE1 537.8690101 499.3583364 576.3796837 1.154240636 0.206944028 0.608109334 1 3.828449608 4.609302644 79960 jade family PHD finger 1 "GO:0000123,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005886,GO:0006915,GO:0016607,GO:0030308,GO:0036064,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0045893,GO:0046872,GO:0090090,GO:2000134" "histone acetyltransferase complex|transcription coactivator activity|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|plasma membrane|apoptotic process|nuclear speck|negative regulation of cell growth|ciliary basal body|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of canonical Wnt signaling pathway|negative regulation of G1/S transition of mitotic cell cycle" JADE2 2392.875225 2065.435396 2720.315054 1.317066155 0.397327812 0.213740632 1 14.83997962 20.38716435 23338 jade family PHD finger 2 "GO:0000123,GO:0005515,GO:0005654,GO:0016567,GO:0016740,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0046872,GO:0070062" histone acetyltransferase complex|protein binding|nucleoplasm|protein ubiquitination|transferase activity|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|metal ion binding|extracellular exosome JADE3 455.9908647 458.7600977 453.2216316 0.987927315 -0.017523193 0.972377215 1 4.659029585 4.801051796 9767 jade family PHD finger 3 "GO:0000123,GO:0005515,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0046872" histone acetyltransferase complex|protein binding|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|metal ion binding JAG1 604.6022419 818.0545105 391.1499734 0.478146588 -1.064475113 0.006794416 0.334878256 6.975012632 3.47874015 182 jagged canonical Notch ligand 1 "GO:0001525,GO:0001709,GO:0001953,GO:0001974,GO:0002011,GO:0002456,GO:0003180,GO:0003184,GO:0003215,GO:0005112,GO:0005198,GO:0005509,GO:0005515,GO:0005543,GO:0005576,GO:0005886,GO:0005887,GO:0005912,GO:0007219,GO:0007399,GO:0008083,GO:0016020,GO:0016324,GO:0022408,GO:0030097,GO:0030216,GO:0030336,GO:0032495,GO:0035909,GO:0042127,GO:0042491,GO:0045445,GO:0045446,GO:0045599,GO:0045602,GO:0045639,GO:0045665,GO:0045669,GO:0045747,GO:0045944,GO:0060411,GO:0061073,GO:0061156,GO:0061309,GO:0061314,GO:0061444,GO:0062043,GO:0072006,GO:0072015,GO:0072017,GO:0072070,GO:0097150,GO:2000737" angiogenesis|cell fate determination|negative regulation of cell-matrix adhesion|blood vessel remodeling|morphogenesis of an epithelial sheet|T cell mediated immunity|aortic valve morphogenesis|pulmonary valve morphogenesis|cardiac right ventricle morphogenesis|Notch binding|structural molecule activity|calcium ion binding|protein binding|phospholipid binding|extracellular region|plasma membrane|integral component of plasma membrane|adherens junction|Notch signaling pathway|nervous system development|growth factor activity|membrane|apical plasma membrane|negative regulation of cell-cell adhesion|hemopoiesis|keratinocyte differentiation|negative regulation of cell migration|response to muramyl dipeptide|aorta morphogenesis|regulation of cell population proliferation|inner ear auditory receptor cell differentiation|myoblast differentiation|endothelial cell differentiation|negative regulation of fat cell differentiation|negative regulation of endothelial cell differentiation|positive regulation of myeloid cell differentiation|negative regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|cardiac septum morphogenesis|ciliary body morphogenesis|pulmonary artery morphogenesis|cardiac neural crest cell development involved in outflow tract morphogenesis|Notch signaling involved in heart development|endocardial cushion cell development|positive regulation of cardiac epithelial to mesenchymal transition|nephron development|glomerular visceral epithelial cell development|distal tubule development|loop of Henle development|neuronal stem cell population maintenance|negative regulation of stem cell differentiation "hsa01522,hsa04330,hsa04371,hsa04658,hsa04668,hsa05165,hsa05200,hsa05224" Endocrine resistance|Notch signaling pathway|Apelin signaling pathway|Th1 and Th2 cell differentiation|TNF signaling pathway|Human papillomavirus infection|Pathways in cancer|Breast cancer JAG2 182.6841556 95.40586103 269.9624501 2.829621233 1.50060895 0.007864265 0.364181927 0.83699468 2.470398035 3714 jagged canonical Notch ligand 2 "GO:0001501,GO:0001701,GO:0003016,GO:0005112,GO:0005509,GO:0005515,GO:0005886,GO:0005887,GO:0007219,GO:0007283,GO:0008083,GO:0009912,GO:0016331,GO:0030154,GO:0030155,GO:0030217,GO:0042127,GO:0042475,GO:0042492,GO:0045061,GO:0045747,GO:1990134" skeletal system development|in utero embryonic development|respiratory system process|Notch binding|calcium ion binding|protein binding|plasma membrane|integral component of plasma membrane|Notch signaling pathway|spermatogenesis|growth factor activity|auditory receptor cell fate commitment|morphogenesis of embryonic epithelium|cell differentiation|regulation of cell adhesion|T cell differentiation|regulation of cell population proliferation|odontogenesis of dentin-containing tooth|gamma-delta T cell differentiation|thymic T cell selection|positive regulation of Notch signaling pathway|epithelial cell apoptotic process involved in palatal shelf morphogenesis "hsa01522,hsa04330,hsa04658,hsa05200,hsa05224" Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Pathways in cancer|Breast cancer JAGN1 1077.044448 1088.032798 1066.056099 0.979801437 -0.029438688 0.935331479 1 31.61504468 32.31080673 84522 jagunal homolog 1 "GO:0002446,GO:0005515,GO:0005783,GO:0005789,GO:0006887,GO:0007029,GO:0015031,GO:0016021,GO:0016192,GO:0030223,GO:0038158,GO:0050832,GO:0061179,GO:1904577,GO:1990266" neutrophil mediated immunity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|exocytosis|endoplasmic reticulum organization|protein transport|integral component of membrane|vesicle-mediated transport|neutrophil differentiation|granulocyte colony-stimulating factor signaling pathway|defense response to fungus|negative regulation of insulin secretion involved in cellular response to glucose stimulus|cellular response to tunicamycin|neutrophil migration JAK1 5197.459347 5199.619426 5195.299268 0.99916914 -0.001199176 0.997710601 1 47.44907762 49.45186968 3716 Janus kinase 1 "GO:0000165,GO:0004713,GO:0004715,GO:0005131,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0005856,GO:0005925,GO:0006468,GO:0016020,GO:0018108,GO:0019221,GO:0019903,GO:0031625,GO:0031730,GO:0034112,GO:0035556,GO:0035722,GO:0035723,GO:0038110,GO:0038111,GO:0038113,GO:0038114,GO:0046677,GO:0046872,GO:0060333,GO:0060334,GO:0060337,GO:0070102,GO:0070106,GO:0070757,GO:0150105,GO:1903672" MAPK cascade|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|growth hormone receptor binding|protein binding|ATP binding|nucleus|cytoplasm|endosome|cytosol|cytoskeleton|focal adhesion|protein phosphorylation|membrane|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|protein phosphatase binding|ubiquitin protein ligase binding|CCR5 chemokine receptor binding|positive regulation of homotypic cell-cell adhesion|intracellular signal transduction|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|interleukin-2-mediated signaling pathway|interleukin-7-mediated signaling pathway|interleukin-9-mediated signaling pathway|interleukin-21-mediated signaling pathway|response to antibiotic|metal ion binding|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway|protein localization to cell-cell junction|positive regulation of sprouting angiogenesis "hsa01521,hsa04151,hsa04217,hsa04380,hsa04550,hsa04621,hsa04630,hsa04658,hsa04659,hsa05140,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200,hsa05203,hsa05212,hsa05235" EGFR tyrosine kinase inhibitor resistance|PI3K-Akt signaling pathway|Necroptosis|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Leishmaniasis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer JAK2 296.379513 256.78386 335.975166 1.308396743 0.387800073 0.415247247 1 1.75059855 2.38914192 3717 Janus kinase 2 "GO:0000165,GO:0000186,GO:0000791,GO:0001774,GO:0002250,GO:0004672,GO:0004713,GO:0004715,GO:0005102,GO:0005131,GO:0005143,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0005925,GO:0006468,GO:0006915,GO:0006919,GO:0007165,GO:0007167,GO:0007186,GO:0007204,GO:0007259,GO:0007260,GO:0007498,GO:0007596,GO:0008022,GO:0008285,GO:0008631,GO:0010667,GO:0010811,GO:0014068,GO:0018108,GO:0019221,GO:0019901,GO:0020037,GO:0022408,GO:0030041,GO:0030154,GO:0030218,GO:0030335,GO:0031103,GO:0031702,GO:0031904,GO:0031959,GO:0032024,GO:0032496,GO:0032516,GO:0032731,GO:0032760,GO:0033130,GO:0033194,GO:0033209,GO:0034612,GO:0035401,GO:0035409,GO:0035556,GO:0035722,GO:0038155,GO:0042169,GO:0042307,GO:0042393,GO:0042531,GO:0042802,GO:0042976,GO:0042981,GO:0043388,GO:0043392,GO:0043524,GO:0043548,GO:0043560,GO:0045121,GO:0045348,GO:0045428,GO:0045429,GO:0045597,GO:0045822,GO:0046425,GO:0046579,GO:0046677,GO:0046777,GO:0046872,GO:0048008,GO:0050727,GO:0050729,GO:0050731,GO:0050804,GO:0050867,GO:0051091,GO:0051428,GO:0051770,GO:0060333,GO:0060334,GO:0060391,GO:0060396,GO:0060397,GO:0060399,GO:0061180,GO:0070102,GO:0070106,GO:0070671,GO:0070757,GO:0097191,GO:0097296,GO:0098794,GO:0098978,GO:0099527,GO:0120162,GO:1902728,GO:1904037,GO:1904707,GO:2000273" MAPK cascade|activation of MAPKK activity|euchromatin|microglial cell activation|adaptive immune response|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|growth hormone receptor binding|interleukin-12 receptor binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|cytoskeleton|plasma membrane|caveola|focal adhesion|protein phosphorylation|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|enzyme linked receptor protein signaling pathway|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|receptor signaling pathway via JAK-STAT|tyrosine phosphorylation of STAT protein|mesoderm development|blood coagulation|protein C-terminus binding|negative regulation of cell population proliferation|intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of cardiac muscle cell apoptotic process|positive regulation of cell-substrate adhesion|positive regulation of phosphatidylinositol 3-kinase signaling|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|protein kinase binding|heme binding|negative regulation of cell-cell adhesion|actin filament polymerization|cell differentiation|erythrocyte differentiation|positive regulation of cell migration|axon regeneration|type 1 angiotensin receptor binding|endosome lumen|mineralocorticoid receptor signaling pathway|positive regulation of insulin secretion|response to lipopolysaccharide|positive regulation of phosphoprotein phosphatase activity|positive regulation of interleukin-1 beta production|positive regulation of tumor necrosis factor production|acetylcholine receptor binding|response to hydroperoxide|tumor necrosis factor-mediated signaling pathway|response to tumor necrosis factor|histone kinase activity (H3-Y41 specific)|histone H3-Y41 phosphorylation|intracellular signal transduction|interleukin-12-mediated signaling pathway|interleukin-23-mediated signaling pathway|SH2 domain binding|positive regulation of protein import into nucleus|histone binding|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|activation of Janus kinase activity|regulation of apoptotic process|positive regulation of DNA binding|negative regulation of DNA binding|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|insulin receptor substrate binding|membrane raft|positive regulation of MHC class II biosynthetic process|regulation of nitric oxide biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of cell differentiation|negative regulation of heart contraction|regulation of receptor signaling pathway via JAK-STAT|positive regulation of Ras protein signal transduction|response to antibiotic|protein autophosphorylation|metal ion binding|platelet-derived growth factor receptor signaling pathway|regulation of inflammatory response|positive regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|modulation of chemical synaptic transmission|positive regulation of cell activation|positive regulation of DNA-binding transcription factor activity|peptide hormone receptor binding|positive regulation of nitric-oxide synthase biosynthetic process|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|positive regulation of SMAD protein signal transduction|growth hormone receptor signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|positive regulation of growth hormone receptor signaling pathway|mammary gland epithelium development|interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|response to interleukin-12|interleukin-35-mediated signaling pathway|extrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|postsynapse|glutamatergic synapse|postsynapse to nucleus signaling pathway|positive regulation of cold-induced thermogenesis|positive regulation of growth factor dependent skeletal muscle satellite cell proliferation|positive regulation of epithelial cell apoptotic process|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of signaling receptor activity "hsa01521,hsa04062,hsa04151,hsa04217,hsa04550,hsa04630,hsa04658,hsa04659,hsa04725,hsa04917,hsa04920,hsa04933,hsa04935,hsa05140,hsa05145,hsa05152,hsa05161,hsa05164,hsa05167,hsa05168,hsa05200,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Chemokine signaling pathway|PI3K-Akt signaling pathway|Necroptosis|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Cholinergic synapse|Prolactin signaling pathway|Adipocytokine signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Leishmaniasis|Toxoplasmosis|Tuberculosis|Hepatitis B|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Pathways in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" JAKMIP3 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.012584611 0.00849513 282973 Janus kinase and microtubule interacting protein 3 "GO:0005794,GO:0008017,GO:0019900" Golgi apparatus|microtubule binding|kinase binding JAM2 46.23047709 28.41876711 64.04218708 2.253517432 1.17217861 0.179968739 1 0.279966991 0.658087559 58494 junctional adhesion molecule 2 "GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0005923,GO:0007286,GO:0007520,GO:0009986,GO:0030198,GO:0031642,GO:0035633,GO:0036477,GO:0044291,GO:0045123,GO:0050900,GO:0050901,GO:0070160,GO:0071593,GO:0097241,GO:0098609,GO:0098636,GO:2000403" integrin binding|protein binding|plasma membrane|integral component of plasma membrane|bicellular tight junction|spermatid development|myoblast fusion|cell surface|extracellular matrix organization|negative regulation of myelination|maintenance of blood-brain barrier|somatodendritic compartment|cell-cell contact zone|cellular extravasation|leukocyte migration|leukocyte tethering or rolling|tight junction|lymphocyte aggregation|hematopoietic stem cell migration to bone marrow|cell-cell adhesion|protein complex involved in cell adhesion|positive regulation of lymphocyte migration "hsa04514,hsa04530,hsa04670,hsa05120" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Epithelial cell signaling in Helicobacter pylori infection JARID2 985.4945297 1026.120484 944.8685755 0.920816405 -0.119014558 0.738062568 1 7.206959171 6.922150533 3720 jumonji and AT-rich interaction domain containing 2 "GO:0000122,GO:0001889,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005739,GO:0006338,GO:0007417,GO:0008134,GO:0010614,GO:0031061,GO:0032452,GO:0034647,GO:0034721,GO:0035097,GO:0035098,GO:0045814,GO:0045892,GO:0048536,GO:0048538,GO:0048863,GO:0051574,GO:0060044,GO:1990830" "negative regulation of transcription by RNA polymerase II|liver development|DNA binding|chromatin binding|nucleus|nucleoplasm|mitochondrion|chromatin remodeling|central nervous system development|transcription factor binding|negative regulation of cardiac muscle hypertrophy|negative regulation of histone methylation|histone demethylase activity|histone demethylase activity (H3-trimethyl-K4 specific)|histone H3-K4 demethylation, trimethyl-H3-K4-specific|histone methyltransferase complex|ESC/E(Z) complex|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|spleen development|thymus development|stem cell differentiation|positive regulation of histone H3-K9 methylation|negative regulation of cardiac muscle cell proliferation|cellular response to leukemia inhibitory factor" hsa04550 Signaling pathways regulating pluripotency of stem cells JAZF1 244.1929121 225.320225 263.0655992 1.167518802 0.223445784 0.662694533 1 3.523209174 4.290602102 221895 JAZF zinc finger 1 "GO:0000122,GO:0001650,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006629,GO:0017053,GO:0046872" negative regulation of transcription by RNA polymerase II|fibrillar center|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|lipid metabolic process|transcription repressor complex|metal ion binding other JCAD 108.4303041 104.5404647 112.3201435 1.07441787 0.103555206 0.888666573 1 0.550718301 0.617189688 57608 junctional cadherin 5 associated "GO:0005912,GO:0007155,GO:0032587,GO:0043410,GO:0048471,GO:0090050,GO:1900748,GO:1903589,GO:1903672" adherens junction|cell adhesion|ruffle membrane|positive regulation of MAPK cascade|perinuclear region of cytoplasm|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of vascular endothelial growth factor signaling pathway|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of sprouting angiogenesis JDP2 190.031823 58.86744617 321.1961998 5.456261834 2.447912878 2.45E-05 0.00544961 0.332229605 1.890816845 122953 Jun dimerization protein 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003682,GO:0005515,GO:0005634,GO:0006357,GO:0031065,GO:0044877,GO:0045599,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|chromatin binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of histone deacetylation|protein-containing complex binding|negative regulation of fat cell differentiation|sequence-specific double-stranded DNA binding" JHY 141.4663536 106.5703767 176.3623306 1.65489075 0.726735978 0.229760957 1 0.692331147 1.195085916 79864 junctional cadherin complex regulator "GO:0005576,GO:0007420,GO:0030154,GO:0035082,GO:0044458,GO:0090175,GO:0090660" extracellular region|brain development|cell differentiation|axoneme assembly|motile cilium assembly|regulation of establishment of planar polarity|cerebrospinal fluid circulation JKAMP 870.6073048 1019.015792 722.1988173 0.708721909 -0.496708447 0.169453133 1 20.41517207 15.09193176 51528 JNK1/MAPK8 associated membrane protein "GO:0005789,GO:0006986,GO:0016021,GO:0030433,GO:0031625" endoplasmic reticulum membrane|response to unfolded protein|integral component of membrane|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding JMJD1C 3437.609829 3032.688434 3842.531225 1.267037913 0.341459695 0.283258746 1 12.27973861 16.22910845 221037 jumonji domain containing 1C "GO:0000118,GO:0000785,GO:0003712,GO:0005515,GO:0005654,GO:0006355,GO:0006357,GO:0007596,GO:0031490,GO:0032454,GO:0033169,GO:0046872,GO:0046966,GO:0051213,GO:0055114" "histone deacetylase complex|chromatin|transcription coregulator activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|blood coagulation|chromatin DNA binding|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|metal ion binding|thyroid hormone receptor binding|dioxygenase activity|oxidation-reduction process" hsa05202 Transcriptional misregulation in cancer chromosome_remodelling_factor JMJD4 364.6636326 412.0721232 317.2551421 0.769901977 -0.37725332 0.397953421 1 7.784408555 6.251395641 65094 jumonji domain containing 4 "GO:0005515,GO:0005737,GO:0016706,GO:0018126,GO:0045905,GO:0046872,GO:0055114" protein binding|cytoplasm|2-oxoglutarate-dependent dioxygenase activity|protein hydroxylation|positive regulation of translational termination|metal ion binding|oxidation-reduction process JMJD6 670.5731421 781.5160956 559.6301886 0.716082742 -0.481801797 0.206461264 1 7.186098987 5.367503447 23210 "jumonji domain containing 6, arginine demethylase and lysine hydroxylase" "GO:0001822,GO:0002040,GO:0003723,GO:0003727,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006397,GO:0006482,GO:0007166,GO:0007507,GO:0008380,GO:0018215,GO:0018395,GO:0030324,GO:0032451,GO:0032452,GO:0033077,GO:0033746,GO:0033749,GO:0035513,GO:0035515,GO:0038023,GO:0042116,GO:0042802,GO:0043654,GO:0045893,GO:0045944,GO:0048024,GO:0048821,GO:0051260,GO:0060041,GO:0070078,GO:0070079,GO:0070815,GO:0106140,GO:0140537,GO:1990904" "kidney development|sprouting angiogenesis|RNA binding|single-stranded RNA binding|iron ion binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|mRNA processing|protein demethylation|cell surface receptor signaling pathway|heart development|RNA splicing|protein phosphopantetheinylation|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|lung development|demethylase activity|histone demethylase activity|T cell differentiation in thymus|histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|oxidative RNA demethylation|oxidative RNA demethylase activity|signaling receptor activity|macrophage activation|identical protein binding|recognition of apoptotic cell|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of mRNA splicing, via spliceosome|erythrocyte development|protein homooligomerization|retina development in camera-type eye|histone H3-R2 demethylation|histone H4-R3 demethylation|peptidyl-lysine 5-dioxygenase activity|P-TEFb complex binding|transcription regulator activator activity|ribonucleoprotein complex" other JMJD7 52.09480466 58.86744617 45.32216316 0.769901977 -0.37725332 0.664819288 1 2.115988983 1.699279298 100137047 jumonji domain containing 7 "GO:0004175,GO:0004177,GO:0004497,GO:0005515,GO:0005634,GO:0005737,GO:0006508,GO:0016706,GO:0018126,GO:0035064,GO:0046872,GO:0055114" endopeptidase activity|aminopeptidase activity|monooxygenase activity|protein binding|nucleus|cytoplasm|proteolysis|2-oxoglutarate-dependent dioxygenase activity|protein hydroxylation|methylated histone binding|metal ion binding|oxidation-reduction process JMJD8 1100.516604 1210.84247 990.1907386 0.817770076 -0.290232823 0.40292708 1 31.70884153 27.04752432 339123 jumonji domain containing 8 "GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005788,GO:0006110,GO:0043123,GO:1903302,GO:1903672" protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|regulation of glycolytic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of pyruvate kinase activity|positive regulation of sprouting angiogenesis JMY 644.2248649 596.7941094 691.6556204 1.158951822 0.212820594 0.58166098 1 3.321485305 4.015259772 133746 "junction mediating and regulatory protein, p53 cofactor" "GO:0003713,GO:0003779,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005856,GO:0006281,GO:0006357,GO:0007050,GO:0031252,GO:0034314,GO:0043065,GO:0045893,GO:0051091,GO:0070060,GO:0070358,GO:0071933,GO:0072332,GO:1901796" "transcription coactivator activity|actin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytoskeleton|DNA repair|regulation of transcription by RNA polymerase II|cell cycle arrest|cell leading edge|Arp2/3 complex-mediated actin nucleation|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex binding|intrinsic apoptotic signaling pathway by p53 class mediator|regulation of signal transduction by p53 class mediator" JOSD1 2387.610172 2008.597861 2766.622482 1.377389937 0.461937042 0.14848602 1 18.21783592 26.17397129 9929 Josephin domain containing 1 "GO:0004843,GO:0005515,GO:0005829,GO:0005886,GO:0016020,GO:0016579,GO:0018215" thiol-dependent ubiquitin-specific protease activity|protein binding|cytosol|plasma membrane|membrane|protein deubiquitination|protein phosphopantetheinylation JOSD2 232.5478884 237.4996966 227.5960802 0.958300509 -0.061449959 0.913070183 1 13.53039571 13.52471577 126119 Josephin domain containing 2 "GO:0004843,GO:0005515,GO:0005829,GO:0016579,GO:0018215" thiol-dependent ubiquitin-specific protease activity|protein binding|cytosol|protein deubiquitination|protein phosphopantetheinylation JPH1 26.92874632 22.3290313 31.52846133 1.411994139 0.4977341 0.644324025 1 0.27355749 0.402900154 56704 junctophilin 1 "GO:0003674,GO:0005515,GO:0005654,GO:0005789,GO:0005886,GO:0007517,GO:0008307,GO:0014701,GO:0016021,GO:0016529,GO:0030018,GO:0030314,GO:0060314,GO:0060402" molecular_function|protein binding|nucleoplasm|endoplasmic reticulum membrane|plasma membrane|muscle organ development|structural constituent of muscle|junctional sarcoplasmic reticulum membrane|integral component of membrane|sarcoplasmic reticulum|Z disc|junctional membrane complex|regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol JPH2 274.2434768 225.320225 323.1667286 1.434255308 0.520301857 0.285487096 1 0.916232398 1.37071776 57158 junctophilin 2 "GO:0001786,GO:0003677,GO:0005515,GO:0005546,GO:0005547,GO:0005634,GO:0005789,GO:0005886,GO:0007275,GO:0010314,GO:0014701,GO:0016021,GO:0016529,GO:0030018,GO:0030314,GO:0032266,GO:0055024,GO:0055074,GO:0060314,GO:0060316,GO:0060402,GO:0070273,GO:0070300,GO:0080025" "phosphatidylserine binding|DNA binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|endoplasmic reticulum membrane|plasma membrane|multicellular organism development|phosphatidylinositol-5-phosphate binding|junctional sarcoplasmic reticulum membrane|integral component of membrane|sarcoplasmic reticulum|Z disc|junctional membrane complex|phosphatidylinositol-3-phosphate binding|regulation of cardiac muscle tissue development|calcium ion homeostasis|regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol|phosphatidylinositol-4-phosphate binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding" JPH4 44.97798871 10.14955968 79.80641774 7.863042361 2.975087627 0.001902375 0.136427449 0.117066589 0.960150936 84502 junctophilin 4 "GO:0005515,GO:0005789,GO:0005886,GO:0014701,GO:0016021,GO:0030314,GO:0048167,GO:0060314,GO:0060402" protein binding|endoplasmic reticulum membrane|plasma membrane|junctional sarcoplasmic reticulum membrane|integral component of membrane|junctional membrane complex|regulation of synaptic plasticity|regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol JPT1 2102.682195 2467.357959 1738.006431 0.704399791 -0.505533614 0.11591153 1 43.4351673 31.91366242 51155 Jupiter microtubule associated homolog 1 "GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0031965" protein binding|nucleoplasm|nucleolus|cytoplasm|nuclear membrane JPT2 3134.189958 3439.685777 2828.69414 0.822369927 -0.282140588 0.375176209 1 47.14694184 40.4423774 90861 Jupiter microtubule associated homolog 2 "GO:0005634,GO:0005829,GO:0005886" nucleus|cytosol|plasma membrane JRK 1386.004269 1396.579412 1375.429125 0.98485565 -0.02201581 0.949866765 1 5.666705689 5.821289099 8629 Jrk helix-turn-helix protein "GO:0003677,GO:0003729,GO:0005515,GO:0005575,GO:0005634,GO:0005737,GO:0090263,GO:1990904" DNA binding|mRNA binding|protein binding|cellular_component|nucleus|cytoplasm|positive regulation of canonical Wnt signaling pathway|ribonucleoprotein complex JRKL 493.3633646 555.1809147 431.5458144 0.777306645 -0.363444244 0.375949084 1 8.954762665 7.260430797 8690 JRK like "GO:0003677,GO:0005634,GO:0007417" DNA binding|nucleus|central nervous system development JTB 1252.402463 1322.487627 1182.3173 0.894010103 -0.161636959 0.63537714 1 52.61534394 49.06488331 10899 jumping translocation breakpoint "GO:0000278,GO:0000281,GO:0005737,GO:0005739,GO:0005813,GO:0005819,GO:0005887,GO:0006915,GO:0016020,GO:0019901,GO:0030496,GO:0045860" mitotic cell cycle|mitotic cytokinesis|cytoplasm|mitochondrion|centrosome|spindle|integral component of plasma membrane|apoptotic process|membrane|protein kinase binding|midbody|positive regulation of protein kinase activity JUN 1594.759829 1960.894931 1228.624727 0.626563264 -0.67446791 0.040936222 0.930085222 30.49198975 19.92813345 3725 "Jun proto-oncogene, AP-1 transcription factor subunit" "GO:0000122,GO:0000228,GO:0000785,GO:0000791,GO:0000976,GO:0000978,GO:0000981,GO:0001102,GO:0001227,GO:0001228,GO:0001525,GO:0001836,GO:0003677,GO:0003700,GO:0003723,GO:0005096,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0005886,GO:0006357,GO:0006366,GO:0007179,GO:0007265,GO:0007568,GO:0007612,GO:0007623,GO:0008134,GO:0009314,GO:0009612,GO:0019899,GO:0031625,GO:0032496,GO:0034097,GO:0034614,GO:0035497,GO:0035976,GO:0038095,GO:0042127,GO:0042493,GO:0042542,GO:0042802,GO:0043065,GO:0043392,GO:0043525,GO:0043547,GO:0043922,GO:0043923,GO:0044389,GO:0044877,GO:0045657,GO:0045740,GO:0045892,GO:0045893,GO:0045944,GO:0051090,GO:0051365,GO:0051591,GO:0051726,GO:0051899,GO:0060395,GO:0070412,GO:0071276,GO:0071837,GO:1902895,GO:1904707,GO:1990441,GO:1990837,GO:2000144" "negative regulation of transcription by RNA polymerase II|nuclear chromosome|chromatin|euchromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|release of cytochrome c from mitochondria|DNA binding|DNA-binding transcription factor activity|RNA binding|GTPase activator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|Ras protein signal transduction|aging|learning|circadian rhythm|transcription factor binding|response to radiation|response to mechanical stimulus|enzyme binding|ubiquitin protein ligase binding|response to lipopolysaccharide|response to cytokine|cellular response to reactive oxygen species|cAMP response element binding|transcription factor AP-1 complex|Fc-epsilon receptor signaling pathway|regulation of cell population proliferation|response to drug|response to hydrogen peroxide|identical protein binding|positive regulation of apoptotic process|negative regulation of DNA binding|positive regulation of neuron apoptotic process|positive regulation of GTPase activity|negative regulation by host of viral transcription|positive regulation by host of viral transcription|ubiquitin-like protein ligase binding|protein-containing complex binding|positive regulation of monocyte differentiation|positive regulation of DNA replication|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of DNA-binding transcription factor activity|cellular response to potassium ion starvation|response to cAMP|regulation of cell cycle|membrane depolarization|SMAD protein signal transduction|R-SMAD binding|cellular response to cadmium ion|HMG box domain binding|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of vascular associated smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|sequence-specific double-stranded DNA binding|positive regulation of DNA-templated transcription, initiation" "hsa01522,hsa04010,hsa04012,hsa04024,hsa04137,hsa04210,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04912,hsa04915,hsa04921,hsa04926,hsa04932,hsa04933,hsa05030,hsa05031,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05161,hsa05162,hsa05166,hsa05167,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05210,hsa05211,hsa05224,hsa05231,hsa05235,hsa05321,hsa05323,hsa05418" Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|cAMP signaling pathway|Mitophagy - animal|Apoptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Cocaine addiction|Amphetamine addiction|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Colorectal cancer|Renal cell carcinoma|Breast cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease|Rheumatoid arthritis|Fluid shear stress and atherosclerosis TF_bZIP JUNB 1023.312403 1152.98998 893.6348258 0.775058623 -0.36762266 0.295057269 1 31.90976775 25.79729234 3726 "JunB proto-oncogene, AP-1 transcription factor subunit" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001570,GO:0001649,GO:0001829,GO:0003677,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0008134,GO:0019221,GO:0030316,GO:0033687,GO:0035976,GO:0042127,GO:0045597,GO:0045944,GO:0046697,GO:0051726,GO:0060136,GO:0060716,GO:0071277,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|vasculogenesis|osteoblast differentiation|trophectodermal cell differentiation|DNA binding|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription factor binding|cytokine-mediated signaling pathway|osteoclast differentiation|osteoblast proliferation|transcription factor AP-1 complex|regulation of cell population proliferation|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|decidualization|regulation of cell cycle|embryonic process involved in female pregnancy|labyrinthine layer blood vessel development|cellular response to calcium ion|sequence-specific double-stranded DNA binding" "hsa04380,hsa04668,hsa04935" "Osteoclast differentiation|TNF signaling pathway|Growth hormone synthesis, secretion and action" TF_bZIP JUND 997.7982108 991.6119811 1003.98444 1.012477118 0.017889303 0.962606385 1 26.03506928 27.49539 3727 "JunD proto-oncogene, AP-1 transcription factor subunit" "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0002076,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0006366,GO:0007568,GO:0007623,GO:0008134,GO:0009416,GO:0009612,GO:0014070,GO:0016922,GO:0019899,GO:0032496,GO:0032993,GO:0035976,GO:0042127,GO:0043434,GO:0045669,GO:0045944,GO:0051726,GO:0071277,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|osteoblast development|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|aging|circadian rhythm|transcription factor binding|response to light stimulus|response to mechanical stimulus|response to organic cyclic compound|nuclear receptor binding|enzyme binding|response to lipopolysaccharide|protein-DNA complex|transcription factor AP-1 complex|regulation of cell population proliferation|response to peptide hormone|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|regulation of cell cycle|cellular response to calcium ion|sequence-specific double-stranded DNA binding" "hsa04010,hsa04380,hsa04657,hsa04928" "MAPK signaling pathway|Osteoclast differentiation|IL-17 signaling pathway|Parathyroid hormone synthesis, secretion and action" TF_bZIP JUP 1220.411061 1324.517539 1116.304584 0.842800908 -0.246736227 0.469998782 1 18.62358154 16.37209022 3728 junction plakoglobin "GO:0001533,GO:0001954,GO:0002159,GO:0003713,GO:0005198,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005882,GO:0005886,GO:0005911,GO:0005912,GO:0005915,GO:0005916,GO:0005925,GO:0009898,GO:0014704,GO:0015629,GO:0016327,GO:0016328,GO:0016342,GO:0016477,GO:0019901,GO:0019903,GO:0030018,GO:0030056,GO:0030057,GO:0031424,GO:0032993,GO:0034332,GO:0035257,GO:0035580,GO:0042127,GO:0042307,GO:0042803,GO:0043312,GO:0043537,GO:0044877,GO:0045294,GO:0045296,GO:0045766,GO:0045944,GO:0050839,GO:0050982,GO:0051091,GO:0070062,GO:0070268,GO:0071603,GO:0071665,GO:0071681,GO:0072659,GO:0086073,GO:0086083,GO:0086091,GO:0090263,GO:0098609,GO:0098911,GO:0106006,GO:1904813" cornified envelope|positive regulation of cell-matrix adhesion|desmosome assembly|transcription coactivator activity|structural molecule activity|protein binding|extracellular region|nucleus|cytoplasm|cytosol|cytoskeleton|intermediate filament|plasma membrane|cell-cell junction|adherens junction|zonula adherens|fascia adherens|focal adhesion|cytoplasmic side of plasma membrane|intercalated disc|actin cytoskeleton|apicolateral plasma membrane|lateral plasma membrane|catenin complex|cell migration|protein kinase binding|protein phosphatase binding|Z disc|hemidesmosome|desmosome|keratinization|protein-DNA complex|adherens junction organization|nuclear hormone receptor binding|specific granule lumen|regulation of cell population proliferation|positive regulation of protein import into nucleus|protein homodimerization activity|neutrophil degranulation|negative regulation of blood vessel endothelial cell migration|protein-containing complex binding|alpha-catenin binding|cadherin binding|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|cell adhesion molecule binding|detection of mechanical stimulus|positive regulation of DNA-binding transcription factor activity|extracellular exosome|cornification|endothelial cell-cell adhesion|gamma-catenin-TCF7L2 complex|cellular response to indole-3-methanol|protein localization to plasma membrane|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|positive regulation of canonical Wnt signaling pathway|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential|cytoskeletal protein-membrane anchor activity|ficolin-1-rich granule lumen "hsa05200,hsa05202,hsa05221,hsa05226,hsa05412" Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy KALRN 14.97196134 13.19442759 16.74949508 1.269437038 0.344188842 0.823644291 1 0.035139676 0.04652912 8997 kalirin RhoGEF kinase "GO:0004674,GO:0005085,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0007165,GO:0007186,GO:0007399,GO:0007411,GO:0007417,GO:0007528,GO:0007595,GO:0007613,GO:0008344,GO:0015629,GO:0016192,GO:0035176,GO:0035556,GO:0042711,GO:0043065,GO:0043547,GO:0046872,GO:0046959,GO:0048013,GO:0051056,GO:0060125,GO:0060137,GO:0061003,GO:0070062,GO:0106310,GO:0106311" protein serine/threonine kinase activity|guanyl-nucleotide exchange factor activity|ATP binding|nucleoplasm|cytosol|protein phosphorylation|signal transduction|G protein-coupled receptor signaling pathway|nervous system development|axon guidance|central nervous system development|neuromuscular junction development|lactation|memory|adult locomotory behavior|actin cytoskeleton|vesicle-mediated transport|social behavior|intracellular signal transduction|maternal behavior|positive regulation of apoptotic process|positive regulation of GTPase activity|metal ion binding|habituation|ephrin receptor signaling pathway|regulation of small GTPase mediated signal transduction|negative regulation of growth hormone secretion|maternal process involved in parturition|positive regulation of dendritic spine morphogenesis|extracellular exosome|protein serine kinase activity|protein threonine kinase activity KANK1 314.1533666 326.8158218 301.4909115 0.922510146 -0.116363317 0.808376228 1 1.563876459 1.504837216 23189 KN motif and ankyrin repeat domains 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0005886,GO:0008013,GO:0008283,GO:0010977,GO:0030036,GO:0030177,GO:0030336,GO:0030837,GO:0032587,GO:0035023,GO:0035024,GO:0046627,GO:0090263,GO:0090303,GO:0090521,GO:1900025,GO:1900028,GO:2000114,GO:2000393" protein binding|nucleus|cytoplasm|cytoskeleton|plasma membrane|beta-catenin binding|cell population proliferation|negative regulation of neuron projection development|actin cytoskeleton organization|positive regulation of Wnt signaling pathway|negative regulation of cell migration|negative regulation of actin filament polymerization|ruffle membrane|regulation of Rho protein signal transduction|negative regulation of Rho protein signal transduction|negative regulation of insulin receptor signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of wound healing|glomerular visceral epithelial cell migration|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of ruffle assembly|regulation of establishment of cell polarity|negative regulation of lamellipodium morphogenesis KANK2 4732.977936 4328.787205 5137.168668 1.186745484 0.24701056 0.440769158 1 39.10073139 48.40145293 25959 KN motif and ankyrin repeat domains 2 "GO:0000122,GO:0005515,GO:0005737,GO:0005739,GO:0006915,GO:0008285,GO:0033147,GO:0035023,GO:0043069,GO:0070563,GO:0072073,GO:0090521,GO:2000134" negative regulation of transcription by RNA polymerase II|protein binding|cytoplasm|mitochondrion|apoptotic process|negative regulation of cell population proliferation|negative regulation of intracellular estrogen receptor signaling pathway|regulation of Rho protein signal transduction|negative regulation of programmed cell death|negative regulation of vitamin D receptor signaling pathway|kidney epithelium development|glomerular visceral epithelial cell migration|negative regulation of G1/S transition of mitotic cell cycle KANSL1 1159.17225 1179.378835 1138.965666 0.965733513 -0.050302952 0.886044762 1 5.66388938 5.705424924 284058 KAT8 regulatory NSL complex subunit 1 "GO:0000123,GO:0000777,GO:0005515,GO:0005634,GO:0005654,GO:0035035,GO:0043981,GO:0043982,GO:0043984,GO:0044545,GO:0071339" histone acetyltransferase complex|condensed chromosome kinetochore|protein binding|nucleus|nucleoplasm|histone acetyltransferase binding|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex|MLL1 complex KANSL1L 131.7473214 115.7049804 147.7896625 1.27729733 0.353094395 0.573002613 1 0.478332305 0.637290797 151050 KAT8 regulatory NSL complex subunit 1 like "GO:0035035,GO:0043981,GO:0043982,GO:0043984,GO:0044545" histone acetyltransferase binding|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex KANSL2 607.8645994 535.8967513 679.8324474 1.268588484 0.343224151 0.379097237 1 11.43753895 15.13454191 54934 KAT8 regulatory NSL complex subunit 2 "GO:0000123,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0015629,GO:0043981,GO:0043982,GO:0043984,GO:0044545" histone acetyltransferase complex|protein binding|nucleoplasm|cytosol|plasma membrane|actin cytoskeleton|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex KANSL3 1420.333385 1284.934256 1555.732514 1.210748726 0.275899485 0.408849173 1 10.2645721 12.96315757 55683 KAT8 regulatory NSL complex subunit 3 "GO:0000123,GO:0005654,GO:0043231,GO:0043981,GO:0043982,GO:0043984,GO:0044545,GO:0045944" histone acetyltransferase complex|nucleoplasm|intracellular membrane-bounded organelle|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex|positive regulation of transcription by RNA polymerase II KARS1 2250.382783 2461.268223 2039.497342 0.828636767 -0.271188261 0.397024396 1 54.55341474 47.15221176 3735 lysyl-tRNA synthetase 1 "GO:0000049,GO:0000187,GO:0002276,GO:0002863,GO:0003877,GO:0004824,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006418,GO:0006430,GO:0008033,GO:0010165,GO:0015966,GO:0016032,GO:0016597,GO:0017101,GO:0033209,GO:0042802,GO:0042803,GO:0043032,GO:0045893,GO:0070371" "tRNA binding|activation of MAPK activity|basophil activation involved in immune response|positive regulation of inflammatory response to antigenic stimulus|ATP adenylyltransferase activity|lysine-tRNA ligase activity|protein binding|ATP binding|extracellular space|nucleus|mitochondrion|mitochondrial matrix|cytosol|plasma membrane|tRNA aminoacylation for protein translation|lysyl-tRNA aminoacylation|tRNA processing|response to X-ray|diadenosine tetraphosphate biosynthetic process|viral process|amino acid binding|aminoacyl-tRNA synthetase multienzyme complex|tumor necrosis factor-mediated signaling pathway|identical protein binding|protein homodimerization activity|positive regulation of macrophage activation|positive regulation of transcription, DNA-templated|ERK1 and ERK2 cascade" hsa00970 Aminoacyl-tRNA biosynthesis KAT14 588.0378232 561.2706505 614.8049959 1.095380625 0.131432267 0.740854851 1 7.069479832 8.077341495 57325 lysine acetyltransferase 14 "GO:0004402,GO:0005515,GO:0005634,GO:0005671,GO:0005737,GO:0030274,GO:0043966" histone acetyltransferase activity|protein binding|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|LIM domain binding|histone H3 acetylation KAT2A 1539.276228 1535.62838 1542.924076 1.004750952 0.006837944 0.985702602 1 23.72610131 24.86570267 2648 lysine acetyltransferase 2A "GO:0000123,GO:0001701,GO:0001756,GO:0001816,GO:0001843,GO:0003682,GO:0003713,GO:0004402,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005671,GO:0005694,GO:0005813,GO:0006338,GO:0006357,GO:0007507,GO:0007616,GO:0008134,GO:0008283,GO:0010484,GO:0014070,GO:0016032,GO:0016573,GO:0016578,GO:0016579,GO:0018215,GO:0018393,GO:0019903,GO:0021537,GO:0022037,GO:0030901,GO:0030914,GO:0031346,GO:0031647,GO:0031667,GO:0033276,GO:0035066,GO:0035264,GO:0042826,GO:0043966,GO:0043983,GO:0043997,GO:0044154,GO:0045252,GO:0045589,GO:0045722,GO:0045815,GO:0045893,GO:0045944,GO:0046600,GO:0048167,GO:0048312,GO:0050863,GO:0060173,GO:0061035,GO:0061733,GO:0071356,GO:0071929,GO:0072686,GO:0106077,GO:0106078,GO:0106227,GO:0106229,GO:1903010,GO:1990090,GO:2000036,GO:2000727" "histone acetyltransferase complex|in utero embryonic development|somitogenesis|cytokine production|neural tube closure|chromatin binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|extracellular space|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|chromosome|centrosome|chromatin remodeling|regulation of transcription by RNA polymerase II|heart development|long-term memory|transcription factor binding|cell population proliferation|H3 histone acetyltransferase activity|response to organic cyclic compound|viral process|histone acetylation|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|internal peptidyl-lysine acetylation|protein phosphatase binding|telencephalon development|metencephalon development|midbrain development|STAGA complex|positive regulation of cell projection organization|regulation of protein stability|response to nutrient levels|transcription factor TFTC complex|positive regulation of histone acetylation|multicellular organism growth|histone deacetylase binding|histone H3 acetylation|histone H4-K12 acetylation|histone acetyltransferase activity (H4-K12 specific)|histone H3-K14 acetylation|oxoglutarate dehydrogenase complex|regulation of regulatory T cell differentiation|positive regulation of gluconeogenesis|positive regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of centriole replication|regulation of synaptic plasticity|intracellular distribution of mitochondria|regulation of T cell activation|limb development|regulation of cartilage development|peptide-lysine-N-acetyltransferase activity|cellular response to tumor necrosis factor|alpha-tubulin acetylation|mitotic spindle|histone succinylation|histone succinyltransferase activity|peptidyl-lysine glutarylation|histone glutaryltransferase activity|regulation of bone development|cellular response to nerve growth factor stimulus|regulation of stem cell population maintenance|positive regulation of cardiac muscle cell differentiation" "hsa04330,hsa04919,hsa05166,hsa05203" Notch signaling pathway|Thyroid hormone signaling pathway|Human T-cell leukemia virus 1 infection|Viral carcinogenesis chromosome_remodelling_factor KAT2B 483.6106815 427.2964627 539.9249003 1.263583829 0.337521379 0.413595049 1 4.652990416 6.132706023 8850 lysine acetyltransferase 2B "GO:0000125,GO:0000776,GO:0000977,GO:0003682,GO:0003712,GO:0003713,GO:0004145,GO:0004402,GO:0004468,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0005813,GO:0005829,GO:0006338,GO:0006367,GO:0006473,GO:0007050,GO:0007219,GO:0007221,GO:0007507,GO:0008134,GO:0008285,GO:0010835,GO:0016032,GO:0016407,GO:0016579,GO:0018076,GO:0018215,GO:0018393,GO:0018394,GO:0019901,GO:0031672,GO:0031674,GO:0032869,GO:0032991,GO:0042641,GO:0042826,GO:0043966,GO:0043970,GO:0045652,GO:0045722,GO:0045736,GO:0045747,GO:0045815,GO:0045944,GO:0046600,GO:0048511,GO:0060173,GO:0061733,GO:2000233" "PCAF complex|kinetochore|RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|diamine N-acetyltransferase activity|histone acetyltransferase activity|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|centrosome|cytosol|chromatin remodeling|transcription initiation from RNA polymerase II promoter|protein acetylation|cell cycle arrest|Notch signaling pathway|positive regulation of transcription of Notch receptor target|heart development|transcription factor binding|negative regulation of cell population proliferation|regulation of protein ADP-ribosylation|viral process|acetyltransferase activity|protein deubiquitination|N-terminal peptidyl-lysine acetylation|protein phosphopantetheinylation|internal peptidyl-lysine acetylation|peptidyl-lysine acetylation|protein kinase binding|A band|I band|cellular response to insulin stimulus|protein-containing complex|actomyosin|histone deacetylase binding|histone H3 acetylation|histone H3-K9 acetylation|regulation of megakaryocyte differentiation|positive regulation of gluconeogenesis|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of Notch signaling pathway|positive regulation of gene expression, epigenetic|positive regulation of transcription by RNA polymerase II|negative regulation of centriole replication|rhythmic process|limb development|peptide-lysine-N-acetyltransferase activity|negative regulation of rRNA processing" "hsa04330,hsa04919,hsa05166,hsa05203" Notch signaling pathway|Thyroid hormone signaling pathway|Human T-cell leukemia virus 1 infection|Viral carcinogenesis chromosome_remodelling_factor KAT5 795.5896378 874.8920447 716.2872308 0.818714989 -0.288566786 0.433229696 1 19.76369118 16.87783475 10524 lysine acetyltransferase 5 "GO:0000122,GO:0000729,GO:0000812,GO:0003712,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0006260,GO:0006302,GO:0006303,GO:0006978,GO:0010212,GO:0010508,GO:0016032,GO:0016407,GO:0016573,GO:0018215,GO:0018394,GO:0032703,GO:0032777,GO:0035267,GO:0040008,GO:0042393,GO:0043161,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0048471,GO:0061733,GO:0070491,GO:0071392,GO:1901796,GO:1901985,GO:1904837" "negative regulation of transcription by RNA polymerase II|DNA double-strand break processing|Swr1 complex|transcription coregulator activity|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|DNA replication|double-strand break repair|double-strand break repair via nonhomologous end joining|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|response to ionizing radiation|positive regulation of autophagy|viral process|acetyltransferase activity|histone acetylation|protein phosphopantetheinylation|peptidyl-lysine acetylation|negative regulation of interleukin-2 production|Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex|regulation of growth|histone binding|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|perinuclear region of cytoplasm|peptide-lysine-N-acetyltransferase activity|repressing transcription factor binding|cellular response to estradiol stimulus|regulation of signal transduction by p53 class mediator|positive regulation of protein acetylation|beta-catenin-TCF complex assembly" "hsa05017,hsa05166" Spinocerebellar ataxia|Human T-cell leukemia virus 1 infection other KAT6A 1512.34476 1546.792896 1477.896625 0.955458632 -0.065734683 0.844347438 1 7.693930801 7.667893887 7994 lysine acetyltransferase 6A "GO:0000786,GO:0003677,GO:0003712,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006323,GO:0006334,GO:0006473,GO:0008134,GO:0008270,GO:0016407,GO:0016573,GO:0016605,GO:0016607,GO:0030099,GO:0042393,GO:0043966,GO:0045892,GO:0045893,GO:0045944,GO:0070776,GO:0090398,GO:1901796" "nucleosome|DNA binding|transcription coregulator activity|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA packaging|nucleosome assembly|protein acetylation|transcription factor binding|zinc ion binding|acetyltransferase activity|histone acetylation|PML body|nuclear speck|myeloid cell differentiation|histone binding|histone H3 acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|MOZ/MORF histone acetyltransferase complex|cellular senescence|regulation of signal transduction by p53 class mediator" hsa04550 Signaling pathways regulating pluripotency of stem cells KAT6B 1356.351819 1457.476771 1255.226867 0.861232846 -0.215524753 0.521732026 1 9.149238567 8.219047045 23522 lysine acetyltransferase 6B "GO:0000786,GO:0003677,GO:0003712,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0006334,GO:0006355,GO:0008134,GO:0016407,GO:0016573,GO:0042393,GO:0043966,GO:0044877,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0070776" "nucleosome|DNA binding|transcription coregulator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|nucleosome assembly|regulation of transcription, DNA-templated|transcription factor binding|acetyltransferase activity|histone acetylation|histone binding|histone H3 acetylation|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|MOZ/MORF histone acetyltransferase complex" KAT7 1171.600141 1086.002886 1257.197396 1.157637251 0.211183251 0.539208515 1 15.30389955 18.47951333 11143 lysine acetyltransferase 7 "GO:0000123,GO:0000775,GO:0001779,GO:0003688,GO:0003712,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006260,GO:0006281,GO:0006355,GO:0008270,GO:0018393,GO:0030174,GO:0031098,GO:0032786,GO:0036409,GO:0042393,GO:0043966,GO:0043967,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0044154,GO:0045648,GO:0045740,GO:0045892,GO:0045944,GO:0072708,GO:0072710,GO:0072716,GO:0072720,GO:0072739,GO:0090240,GO:0090734,GO:1900182,GO:1902035,GO:2000819" "histone acetyltransferase complex|chromosome, centromeric region|natural killer cell differentiation|DNA replication origin binding|transcription coregulator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|DNA replication|DNA repair|regulation of transcription, DNA-templated|zinc ion binding|internal peptidyl-lysine acetylation|regulation of DNA-dependent DNA replication initiation|stress-activated protein kinase signaling cascade|positive regulation of DNA-templated transcription, elongation|histone H3-K14 acetyltransferase complex|histone binding|histone H3 acetylation|histone H4 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|histone H3-K14 acetylation|positive regulation of erythrocyte differentiation|positive regulation of DNA replication|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|response to sorbitol|response to hydroxyurea|response to actinomycin D|response to dithiothreitol|response to anisomycin|positive regulation of histone H4 acetylation|site of DNA damage|positive regulation of protein localization to nucleus|positive regulation of hematopoietic stem cell proliferation|regulation of nucleotide-excision repair" KAT8 437.5704779 445.5656701 429.5752856 0.964112171 -0.052727086 0.906129275 1 9.794413772 9.849675945 84148 lysine acetyltransferase 8 "GO:0000123,GO:0000776,GO:0003712,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0008134,GO:0010506,GO:0016363,GO:0016407,GO:0016573,GO:0019899,GO:0030099,GO:0035064,GO:0042393,GO:0043981,GO:0043982,GO:0043984,GO:0043995,GO:0043996,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0046972,GO:0071339,GO:0072487" "histone acetyltransferase complex|kinetochore|transcription coregulator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription factor binding|regulation of autophagy|nuclear matrix|acetyltransferase activity|histone acetylation|enzyme binding|myeloid cell differentiation|methylated histone binding|histone binding|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|histone acetyltransferase activity (H4-K5 specific)|histone acetyltransferase activity (H4-K8 specific)|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|histone acetyltransferase activity (H4-K16 specific)|MLL1 complex|MSL complex" other KATNA1 298.1070662 307.5316584 288.682474 0.93870815 -0.09125141 0.853596364 1 6.305827365 6.174312334 11104 katanin catalytic subunit A1 "GO:0000922,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005874,GO:0007049,GO:0008017,GO:0008568,GO:0015630,GO:0016853,GO:0016887,GO:0030496,GO:0031122,GO:0046982,GO:0051013,GO:0051301,GO:0097431" spindle pole|protein binding|ATP binding|nucleus|cytoplasm|centrosome|spindle|microtubule|cell cycle|microtubule binding|microtubule-severing ATPase activity|microtubule cytoskeleton|isomerase activity|ATPase activity|midbody|cytoplasmic microtubule organization|protein heterodimerization activity|microtubule severing|cell division|mitotic spindle pole KATNAL1 1014.623419 794.7105232 1234.536314 1.553441508 0.635467921 0.071109307 1 3.533118367 5.724914732 84056 katanin catalytic subunit A1 like 1 "GO:0000922,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005874,GO:0007283,GO:0008017,GO:0008568,GO:0015630,GO:0016853,GO:0016887,GO:0031122,GO:0042802,GO:0051013" spindle pole|protein binding|ATP binding|nucleus|cytoplasm|centrosome|spindle|microtubule|spermatogenesis|microtubule binding|microtubule-severing ATPase activity|microtubule cytoskeleton|isomerase activity|ATPase activity|cytoplasmic microtubule organization|identical protein binding|microtubule severing KATNAL2 5.04508829 8.119647747 1.970528833 0.242686493 -2.042834281 0.307402201 1 0.047762081 0.012090514 83473 katanin catalytic subunit A1 like 2 "GO:0000922,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0005874,GO:0008017,GO:0008568,GO:0016853,GO:0016887,GO:0031122,GO:0051013" spindle pole|protein binding|ATP binding|nucleus|cytoplasm|spindle|microtubule|microtubule binding|microtubule-severing ATPase activity|isomerase activity|ATPase activity|cytoplasmic microtubule organization|microtubule severing KATNB1 766.0250243 773.3964479 758.6536007 0.980937529 -0.027766833 0.943975719 1 14.96172716 15.30872462 10300 katanin regulatory subunit B1 "GO:0000922,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0005886,GO:0006605,GO:0007019,GO:0007026,GO:0007079,GO:0008017,GO:0008352,GO:0010942,GO:0010976,GO:0015630,GO:0016020,GO:0030426,GO:0030496,GO:0031117,GO:0043025,GO:0046982,GO:0050790,GO:0051013,GO:0051301,GO:0060590,GO:0070840" spindle pole|protein binding|nucleus|cytoplasm|centrosome|spindle|cytosol|microtubule|plasma membrane|protein targeting|microtubule depolymerization|negative regulation of microtubule depolymerization|mitotic chromosome movement towards spindle pole|microtubule binding|katanin complex|positive regulation of cell death|positive regulation of neuron projection development|microtubule cytoskeleton|membrane|growth cone|midbody|positive regulation of microtubule depolymerization|neuronal cell body|protein heterodimerization activity|regulation of catalytic activity|microtubule severing|cell division|ATPase regulator activity|dynein complex binding KATNBL1 267.3439043 258.8137719 275.8740366 1.065917144 0.092095299 0.857963262 1 2.91548143 3.241527099 79768 katanin regulatory subunit B1 like 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0008017,GO:0030496,GO:0032154,GO:0051495,GO:0072686,GO:0097431" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|microtubule binding|midbody|cleavage furrow|positive regulation of cytoskeleton organization|mitotic spindle|mitotic spindle pole KATNIP 785.7654474 708.4392659 863.0916289 1.218300101 0.284869552 0.440365541 1 5.166299438 6.56522756 23247 katanin interacting protein "GO:0005615,GO:0005737,GO:0005856,GO:0042995,GO:0090660" extracellular space|cytoplasm|cytoskeleton|cell projection|cerebrospinal fluid circulation KAZALD1 765.8481128 929.699667 601.9965585 0.647517236 -0.6270095 0.091086654 1 9.278031202 6.266471828 81621 Kazal type serine peptidase inhibitor domain 1 "GO:0001503,GO:0001558,GO:0005515,GO:0005520,GO:0005614,GO:0007275,GO:0009966,GO:0030154,GO:0030198" ossification|regulation of cell growth|protein binding|insulin-like growth factor binding|interstitial matrix|multicellular organism development|regulation of signal transduction|cell differentiation|extracellular matrix organization KAZN 128.5903683 202.9911937 54.18954291 0.266955142 -1.905330758 0.003013785 0.187933644 0.638399643 0.177765245 23254 "kazrin, periplakin interacting protein" "GO:0001533,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0016607,GO:0030057,GO:0070268" cornified envelope|protein binding|nucleoplasm|cytosol|cytoskeleton|nuclear speck|desmosome|cornification KBTBD11 28.00308539 28.41876711 27.58740366 0.970745971 -0.042834281 1 1 0.173285613 0.175462387 9920 kelch repeat and BTB domain containing 11 KBTBD2 1678.60479 1496.045097 1861.164483 1.244056403 0.315051896 0.335867849 1 19.98138356 25.92874861 25948 kelch repeat and BTB domain containing 2 "GO:0006006,GO:0006629,GO:0010467,GO:0014065,GO:0032868" glucose metabolic process|lipid metabolic process|gene expression|phosphatidylinositol 3-kinase signaling|response to insulin KBTBD3 106.2046755 120.7797602 91.62959074 0.758650212 -0.398493233 0.553822996 1 0.727183639 0.575442074 143879 kelch repeat and BTB domain containing 3 KBTBD4 509.9144214 608.973581 410.8552617 0.67466845 -0.567749398 0.162835074 1 11.45279003 8.059676853 55709 kelch repeat and BTB domain containing 4 KBTBD6 293.1955899 308.5466144 277.8445655 0.900494617 -0.151210442 0.755992678 1 2.985631932 2.80435712 89890 kelch repeat and BTB domain containing 6 "GO:0003674,GO:0005515,GO:0005575,GO:0005829,GO:0008150,GO:0043687" molecular_function|protein binding|cellular_component|cytosol|biological_process|post-translational protein modification KBTBD7 132.4005356 160.363043 104.4380282 0.651259955 -0.618694575 0.317454459 1 1.714911825 1.164962912 84078 kelch repeat and BTB domain containing 7 "GO:0000165,GO:0003674,GO:0005515,GO:0005575,GO:0005829,GO:0008150,GO:0043687" MAPK cascade|molecular_function|protein binding|cellular_component|cytosol|biological_process|post-translational protein modification KBTBD8 25.16605835 36.53841486 13.79370183 0.377512322 -1.405404361 0.180675619 1 0.504785001 0.19877122 84541 kelch repeat and BTB domain containing 8 "GO:0005515,GO:0005794,GO:0005819,GO:0005829,GO:0006417,GO:0006513,GO:0014029,GO:0014032,GO:0031463,GO:0043687" protein binding|Golgi apparatus|spindle|cytosol|regulation of translation|protein monoubiquitination|neural crest formation|neural crest cell development|Cul3-RING ubiquitin ligase complex|post-translational protein modification KCMF1 852.227496 873.8770888 830.5779031 0.95045163 -0.073314888 0.842638051 1 11.40690508 11.30872848 56888 potassium channel modulatory factor 1 "GO:0005576,GO:0005829,GO:0005886,GO:0008270,GO:0016567,GO:0043312,GO:0045202,GO:0061630,GO:0099536,GO:1904813" extracellular region|cytosol|plasma membrane|zinc ion binding|protein ubiquitination|neutrophil degranulation|synapse|ubiquitin protein ligase activity|synaptic signaling|ficolin-1-rich granule lumen KCNAB2 2012.355319 2051.226012 1973.484626 0.962100039 -0.055741182 0.863952665 1 20.12540899 20.1967215 8514 potassium voltage-gated channel subfamily A regulatory beta subunit 2 "GO:0004033,GO:0005249,GO:0005515,GO:0005829,GO:0005874,GO:0005886,GO:0008076,GO:0015459,GO:0016020,GO:0031234,GO:0035579,GO:0043312,GO:0044224,GO:0044325,GO:0045202,GO:0055114,GO:0070821,GO:0070995,GO:0071805,GO:0098900,GO:1901379,GO:1990031,GO:2000008" aldo-keto reductase (NADP) activity|voltage-gated potassium channel activity|protein binding|cytosol|microtubule|plasma membrane|voltage-gated potassium channel complex|potassium channel regulator activity|membrane|extrinsic component of cytoplasmic side of plasma membrane|specific granule membrane|neutrophil degranulation|juxtaparanode region of axon|ion channel binding|synapse|oxidation-reduction process|tertiary granule membrane|NADPH oxidation|potassium ion transmembrane transport|regulation of action potential|regulation of potassium ion transmembrane transport|pinceau fiber|regulation of protein localization to cell surface KCNAB3 38.5710484 43.64310664 33.49899016 0.767566581 -0.381636195 0.694228014 1 0.646117915 0.517301539 9196 potassium voltage-gated channel subfamily A regulatory beta subunit 3 "GO:0004033,GO:0005249,GO:0005515,GO:0005737,GO:0005886,GO:0006813,GO:0008076,GO:0015459,GO:0044325,GO:0055114,GO:0071805,GO:1901379" aldo-keto reductase (NADP) activity|voltage-gated potassium channel activity|protein binding|cytoplasm|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium channel regulator activity|ion channel binding|oxidation-reduction process|potassium ion transmembrane transport|regulation of potassium ion transmembrane transport KCNC4 144.3924553 104.5404647 184.2444459 1.762422296 0.817559651 0.173843938 1 0.852868193 1.567861971 3749 potassium voltage-gated channel subfamily C member 4 "GO:0005249,GO:0005251,GO:0005267,GO:0005515,GO:0005886,GO:0006813,GO:0007268,GO:0008076,GO:0016021,GO:0030424,GO:0032590,GO:0032809,GO:0034765,GO:0045202,GO:0051260,GO:0071805" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|potassium channel activity|protein binding|plasma membrane|potassium ion transport|chemical synaptic transmission|voltage-gated potassium channel complex|integral component of membrane|axon|dendrite membrane|neuronal cell body membrane|regulation of ion transmembrane transport|synapse|protein homooligomerization|potassium ion transmembrane transport KCND1 246.9084513 242.5744764 251.2424262 1.035733148 0.050652348 0.928113016 1 2.034030046 2.197460968 3750 potassium voltage-gated channel subfamily D member 1 "GO:0005249,GO:0005250,GO:0005575,GO:0005886,GO:0008076,GO:0014069,GO:0016021,GO:0034765,GO:0043025,GO:0043197,GO:0045211,GO:0046872,GO:0051260,GO:0061337,GO:0071805" voltage-gated potassium channel activity|A-type (transient outward) potassium channel activity|cellular_component|plasma membrane|voltage-gated potassium channel complex|postsynaptic density|integral component of membrane|regulation of ion transmembrane transport|neuronal cell body|dendritic spine|postsynaptic membrane|metal ion binding|protein homooligomerization|cardiac conduction|potassium ion transmembrane transport KCND2 204.1439671 181.6771183 226.6108158 1.247327225 0.318839992 0.55493178 1 0.950842733 1.237100615 3751 potassium voltage-gated channel subfamily D member 2 "GO:0001508,GO:0005249,GO:0005250,GO:0005515,GO:0005886,GO:0005887,GO:0007268,GO:0008076,GO:0014069,GO:0016021,GO:0019228,GO:0019233,GO:0031226,GO:0032809,GO:0034765,GO:0043197,GO:0043204,GO:0044853,GO:0045211,GO:0045475,GO:0046872,GO:0051260,GO:0060078,GO:0061337,GO:0071456,GO:0071805,GO:0098978,GO:0098982,GO:0099060,GO:1905030" action potential|voltage-gated potassium channel activity|A-type (transient outward) potassium channel activity|protein binding|plasma membrane|integral component of plasma membrane|chemical synaptic transmission|voltage-gated potassium channel complex|postsynaptic density|integral component of membrane|neuronal action potential|sensory perception of pain|intrinsic component of plasma membrane|neuronal cell body membrane|regulation of ion transmembrane transport|dendritic spine|perikaryon|plasma membrane raft|postsynaptic membrane|locomotor rhythm|metal ion binding|protein homooligomerization|regulation of postsynaptic membrane potential|cardiac conduction|cellular response to hypoxia|potassium ion transmembrane transport|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic specialization membrane|voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential hsa04726 Serotonergic synapse KCNE3 8.508359524 9.134603715 7.882115332 0.862885307 -0.212759283 0.973293498 1 0.135869443 0.122289959 10008 potassium voltage-gated channel subfamily E regulatory subunit 3 "GO:0005251,GO:0005515,GO:0005737,GO:0005886,GO:0008076,GO:0015459,GO:0030425,GO:0031982,GO:0032809,GO:0043204,GO:0044325,GO:0045121,GO:0060307,GO:0086005,GO:0086011,GO:0086091,GO:0097623,GO:0098915,GO:1901387,GO:1902260,GO:1902282,GO:1903765,GO:1903817,GO:1905025" delayed rectifier potassium channel activity|protein binding|cytoplasm|plasma membrane|voltage-gated potassium channel complex|potassium channel regulator activity|dendrite|vesicle|neuronal cell body membrane|perikaryon|ion channel binding|membrane raft|regulation of ventricular cardiac muscle cell membrane repolarization|ventricular cardiac muscle cell action potential|membrane repolarization during action potential|regulation of heart rate by cardiac conduction|potassium ion export across plasma membrane|membrane repolarization during ventricular cardiac muscle cell action potential|positive regulation of voltage-gated calcium channel activity|negative regulation of delayed rectifier potassium channel activity|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|negative regulation of potassium ion export across plasma membrane|negative regulation of voltage-gated potassium channel activity|negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential hsa04974 Protein digestion and absorption KCNE5 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.104692341 0.141343282 23630 potassium voltage-gated channel subfamily E regulatory subunit 5 "GO:0005249,GO:0005251,GO:0005515,GO:0005886,GO:0008016,GO:0008076,GO:0015459,GO:0044325,GO:0060048,GO:0060306,GO:0060307,GO:0060372,GO:0086005,GO:0086008,GO:0086011,GO:0086014,GO:0086091,GO:0097623,GO:0098915,GO:1901379,GO:1901380,GO:1901381,GO:1902260,GO:1902282,GO:1903765,GO:2001257" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|protein binding|plasma membrane|regulation of heart contraction|voltage-gated potassium channel complex|potassium channel regulator activity|ion channel binding|cardiac muscle contraction|regulation of membrane repolarization|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane repolarization|ventricular cardiac muscle cell action potential|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|membrane repolarization during action potential|atrial cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|potassium ion export across plasma membrane|membrane repolarization during ventricular cardiac muscle cell action potential|regulation of potassium ion transmembrane transport|negative regulation of potassium ion transmembrane transport|positive regulation of potassium ion transmembrane transport|negative regulation of delayed rectifier potassium channel activity|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|negative regulation of potassium ion export across plasma membrane|regulation of cation channel activity KCNG1 23.00253443 23.34398727 22.66108158 0.970745971 -0.042834281 1 1 0.240156531 0.243173322 3755 potassium voltage-gated channel modifier subfamily G member 1 "GO:0005249,GO:0005251,GO:0005267,GO:0005886,GO:0006813,GO:0008076,GO:0016021,GO:0051260,GO:0071805,GO:1902259" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|potassium channel activity|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|integral component of membrane|protein homooligomerization|potassium ion transmembrane transport|regulation of delayed rectifier potassium channel activity KCNH1 53.63208439 62.92727004 44.33689874 0.704573688 -0.505177495 0.550725278 1 0.375830688 0.276206942 3756 potassium voltage-gated channel subfamily H member 1 "GO:0005249,GO:0005251,GO:0005515,GO:0005516,GO:0005637,GO:0005886,GO:0005887,GO:0006813,GO:0007520,GO:0008076,GO:0030424,GO:0030425,GO:0030551,GO:0031901,GO:0034765,GO:0042127,GO:0042391,GO:0042734,GO:0043204,GO:0043231,GO:0048015,GO:0071277,GO:0071805,GO:0098839,GO:1902936" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|protein binding|calmodulin binding|nuclear inner membrane|plasma membrane|integral component of plasma membrane|potassium ion transport|myoblast fusion|voltage-gated potassium channel complex|axon|dendrite|cyclic nucleotide binding|early endosome membrane|regulation of ion transmembrane transport|regulation of cell population proliferation|regulation of membrane potential|presynaptic membrane|perikaryon|intracellular membrane-bounded organelle|phosphatidylinositol-mediated signaling|cellular response to calcium ion|potassium ion transmembrane transport|postsynaptic density membrane|phosphatidylinositol bisphosphate binding KCNH3 45.46789932 43.64310664 47.29269199 1.083623409 0.115863465 0.919899646 1 0.481457065 0.544191648 23416 potassium voltage-gated channel subfamily H member 3 "GO:0005249,GO:0005515,GO:0005886,GO:0005887,GO:0006813,GO:0016021,GO:0034765,GO:0042391,GO:0071805" voltage-gated potassium channel activity|protein binding|plasma membrane|integral component of plasma membrane|potassium ion transport|integral component of membrane|regulation of ion transmembrane transport|regulation of membrane potential|potassium ion transmembrane transport KCNH8 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.035788308 0.024158581 131096 potassium voltage-gated channel subfamily H member 8 "GO:0005249,GO:0005886,GO:0005887,GO:0034765,GO:0042391,GO:0071805" voltage-gated potassium channel activity|plasma membrane|integral component of plasma membrane|regulation of ion transmembrane transport|regulation of membrane potential|potassium ion transmembrane transport KCNIP2 71.05236099 75.10674166 66.99798033 0.892036838 -0.164824806 0.844116921 1 1.353216473 1.259116731 30819 potassium voltage-gated channel interacting protein 2 "GO:0005250,GO:0005509,GO:0005513,GO:0005515,GO:0005737,GO:0005886,GO:0006813,GO:0006936,GO:0007165,GO:0007268,GO:0008016,GO:0008076,GO:0015459,GO:0034705,GO:0044325,GO:0045163,GO:0045202,GO:0046923,GO:0047485,GO:0061337,GO:0086008,GO:0086009,GO:0086013,GO:0097623,GO:1901379,GO:1903766,GO:1903818" A-type (transient outward) potassium channel activity|calcium ion binding|detection of calcium ion|protein binding|cytoplasm|plasma membrane|potassium ion transport|muscle contraction|signal transduction|chemical synaptic transmission|regulation of heart contraction|voltage-gated potassium channel complex|potassium channel regulator activity|potassium channel complex|ion channel binding|clustering of voltage-gated potassium channels|synapse|ER retention sequence binding|protein N-terminus binding|cardiac conduction|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|membrane repolarization|membrane repolarization during cardiac muscle cell action potential|potassium ion export across plasma membrane|regulation of potassium ion transmembrane transport|positive regulation of potassium ion export across plasma membrane|positive regulation of voltage-gated potassium channel activity KCNIP3 88.6507869 99.4656849 77.83588891 0.782540119 -0.353763377 0.623628016 1 1.501068548 1.225245361 30818 potassium voltage-gated channel interacting protein 3 "GO:0000122,GO:0000978,GO:0001227,GO:0005244,GO:0005267,GO:0005509,GO:0005515,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006886,GO:0006915,GO:0007165,GO:0008076,GO:0015459,GO:0030425,GO:0032993,GO:0043679,GO:0044325,GO:0061337,GO:0071805,GO:0072659,GO:1901379" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|voltage-gated ion channel activity|potassium channel activity|calcium ion binding|protein binding|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|intracellular protein transport|apoptotic process|signal transduction|voltage-gated potassium channel complex|potassium channel regulator activity|dendrite|protein-DNA complex|axon terminus|ion channel binding|cardiac conduction|potassium ion transmembrane transport|protein localization to plasma membrane|regulation of potassium ion transmembrane transport" KCNJ11 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.026333985 0.053329573 3767 potassium inwardly rectifying channel subfamily J member 11 "GO:0001669,GO:0002931,GO:0005242,GO:0005249,GO:0005515,GO:0005524,GO:0005635,GO:0005739,GO:0005768,GO:0005783,GO:0005829,GO:0005886,GO:0005887,GO:0006006,GO:0008022,GO:0008282,GO:0014704,GO:0015272,GO:0019829,GO:0030315,GO:0030506,GO:0030673,GO:0030955,GO:0031072,GO:0032355,GO:0033198,GO:0033574,GO:0034765,GO:0042391,GO:0042493,GO:0043025,GO:0043209,GO:0044325,GO:0046676,GO:0050796,GO:0050877,GO:0055085,GO:0070852,GO:0071316,GO:0071333,GO:0071356,GO:0071805,GO:0098662,GO:1903078,GO:1903779,GO:1990573,GO:2001259" acrosomal vesicle|response to ischemia|inward rectifier potassium channel activity|voltage-gated potassium channel activity|protein binding|ATP binding|nuclear envelope|mitochondrion|endosome|endoplasmic reticulum|cytosol|plasma membrane|integral component of plasma membrane|glucose metabolic process|protein C-terminus binding|inward rectifying potassium channel|intercalated disc|ATP-activated inward rectifier potassium channel activity|ATPase-coupled cation transmembrane transporter activity|T-tubule|ankyrin binding|axolemma|potassium ion binding|heat shock protein binding|response to estradiol|response to ATP|response to testosterone|regulation of ion transmembrane transport|regulation of membrane potential|response to drug|neuronal cell body|myelin sheath|ion channel binding|negative regulation of insulin secretion|regulation of insulin secretion|nervous system process|transmembrane transport|cell body fiber|cellular response to nicotine|cellular response to glucose stimulus|cellular response to tumor necrosis factor|potassium ion transmembrane transport|inorganic cation transmembrane transport|positive regulation of protein localization to plasma membrane|regulation of cardiac conduction|potassium ion import across plasma membrane|positive regulation of cation channel activity "hsa04911,hsa04929,hsa04930" Insulin secretion|GnRH secretion|Type II diabetes mellitus KCNJ12 22.22511087 37.55337083 6.896850916 0.183654643 -2.444932725 0.031668657 0.796358016 0.323240271 0.061921762 3768 potassium inwardly rectifying channel subfamily J member 12 "GO:0005242,GO:0005515,GO:0005886,GO:0006813,GO:0006936,GO:0008016,GO:0016021,GO:0031224,GO:0034765,GO:0051289,GO:0061337,GO:1990573" inward rectifier potassium channel activity|protein binding|plasma membrane|potassium ion transport|muscle contraction|regulation of heart contraction|integral component of membrane|intrinsic component of membrane|regulation of ion transmembrane transport|protein homotetramerization|cardiac conduction|potassium ion import across plasma membrane "hsa04725,hsa04921" Cholinergic synapse|Oxytocin signaling pathway KCNJ14 27.97339384 26.38885518 29.5579325 1.120091504 0.163616596 0.905985708 1 0.346783192 0.405160849 3770 potassium inwardly rectifying channel subfamily J member 14 "GO:0005242,GO:0005886,GO:0008076,GO:0030425,GO:0034765,GO:0043025,GO:0061337,GO:1990573" inward rectifier potassium channel activity|plasma membrane|voltage-gated potassium channel complex|dendrite|regulation of ion transmembrane transport|neuronal cell body|cardiac conduction|potassium ion import across plasma membrane "hsa04725,hsa04921" Cholinergic synapse|Oxytocin signaling pathway KCNJ16 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.033163832 0.011193476 3773 potassium inwardly rectifying channel subfamily J member 16 "GO:0005242,GO:0005886,GO:0006813,GO:0008076,GO:0016323,GO:0034765,GO:1990573" inward rectifier potassium channel activity|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|basolateral plasma membrane|regulation of ion transmembrane transport|potassium ion import across plasma membrane hsa04971 Gastric acid secretion KCNJ2 1065.018632 1377.295249 752.7420142 0.54653642 -0.871610459 0.012852809 0.502037376 12.93918486 7.376357461 3759 potassium inwardly rectifying channel subfamily J member 2 "GO:0005242,GO:0005515,GO:0005546,GO:0005790,GO:0005791,GO:0005794,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0014704,GO:0014861,GO:0015693,GO:0030007,GO:0030315,GO:0031224,GO:0034765,GO:0042802,GO:0043025,GO:0043197,GO:0051289,GO:0055119,GO:0060075,GO:0060306,GO:0061337,GO:0071260,GO:0071805,GO:0086002,GO:0086004,GO:0086008,GO:0086011,GO:0086012,GO:0086013,GO:0086091,GO:0090076,GO:1901381,GO:1990573" "inward rectifier potassium channel activity|protein binding|phosphatidylinositol-4,5-bisphosphate binding|smooth endoplasmic reticulum|rough endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|intercalated disc|regulation of skeletal muscle contraction via regulation of action potential|magnesium ion transport|cellular potassium ion homeostasis|T-tubule|intrinsic component of membrane|regulation of ion transmembrane transport|identical protein binding|neuronal cell body|dendritic spine|protein homotetramerization|relaxation of cardiac muscle|regulation of resting membrane potential|regulation of membrane repolarization|cardiac conduction|cellular response to mechanical stimulus|potassium ion transmembrane transport|cardiac muscle cell action potential involved in contraction|regulation of cardiac muscle cell contraction|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|membrane repolarization during action potential|membrane depolarization during cardiac muscle cell action potential|membrane repolarization during cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|relaxation of skeletal muscle|positive regulation of potassium ion transmembrane transport|potassium ion import across plasma membrane" "hsa04725,hsa04921,hsa04924,hsa04971" Cholinergic synapse|Oxytocin signaling pathway|Renin secretion|Gastric acid secretion KCNJ5 3.537500113 6.08973581 0.985264417 0.161790995 -2.627796782 0.2971307 1 0.049874456 0.008416828 3762 potassium inwardly rectifying channel subfamily J member 5 "GO:0005242,GO:0005515,GO:0005886,GO:0006813,GO:0008076,GO:0009897,GO:0015467,GO:0030315,GO:0034765,GO:0086089,GO:0086091,GO:0098914,GO:0098915,GO:0099625,GO:1902282,GO:1990573" inward rectifier potassium channel activity|protein binding|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|external side of plasma membrane|G-protein activated inward rectifier potassium channel activity|T-tubule|regulation of ion transmembrane transport|voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|regulation of heart rate by cardiac conduction|membrane repolarization during atrial cardiac muscle cell action potential|membrane repolarization during ventricular cardiac muscle cell action potential|ventricular cardiac muscle cell membrane repolarization|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|potassium ion import across plasma membrane "hsa04713,hsa04723,hsa04726,hsa04728,hsa04915,hsa04921,hsa04925,hsa04929,hsa05032" Circadian entrainment|Retrograde endocannabinoid signaling|Serotonergic synapse|Dopaminergic synapse|Estrogen signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|GnRH secretion|Morphine addiction KCNJ8 81.89026957 75.10674166 88.67379749 1.180636991 0.239565449 0.752699104 1 1.552608777 1.912028463 3764 potassium inwardly rectifying channel subfamily J member 8 "GO:0001822,GO:0005242,GO:0005515,GO:0005524,GO:0005739,GO:0005886,GO:0006813,GO:0007507,GO:0008076,GO:0008282,GO:0015272,GO:0017098,GO:0019829,GO:0030016,GO:0031004,GO:0032496,GO:0034765,GO:0042383,GO:0043330,GO:0051607,GO:0071805,GO:0098662,GO:0098915,GO:0150104,GO:1902282,GO:1990573" kidney development|inward rectifier potassium channel activity|protein binding|ATP binding|mitochondrion|plasma membrane|potassium ion transport|heart development|voltage-gated potassium channel complex|inward rectifying potassium channel|ATP-activated inward rectifier potassium channel activity|sulfonylurea receptor binding|ATPase-coupled cation transmembrane transporter activity|myofibril|potassium ion-transporting ATPase complex|response to lipopolysaccharide|regulation of ion transmembrane transport|sarcolemma|response to exogenous dsRNA|defense response to virus|potassium ion transmembrane transport|inorganic cation transmembrane transport|membrane repolarization during ventricular cardiac muscle cell action potential|transport across blood-brain barrier|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|potassium ion import across plasma membrane hsa04022 cGMP-PKG signaling pathway KCNK1 351.2668074 304.4867905 398.0468243 1.30727124 0.386558511 0.39177036 1 5.636396847 7.685695957 3775 potassium two pore domain channel subfamily K member 1 "GO:0005242,GO:0005249,GO:0005267,GO:0005272,GO:0005515,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0016021,GO:0016324,GO:0022841,GO:0030322,GO:0030425,GO:0031526,GO:0034705,GO:0035094,GO:0035725,GO:0042802,GO:0043204,GO:0043231,GO:0055037,GO:0060075,GO:0061337,GO:0071805,GO:0097060,GO:1902937" inward rectifier potassium channel activity|voltage-gated potassium channel activity|potassium channel activity|sodium channel activity|protein binding|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|integral component of membrane|apical plasma membrane|potassium ion leak channel activity|stabilization of membrane potential|dendrite|brush border membrane|potassium channel complex|response to nicotine|sodium ion transmembrane transport|identical protein binding|perikaryon|intracellular membrane-bounded organelle|recycling endosome|regulation of resting membrane potential|cardiac conduction|potassium ion transmembrane transport|synaptic membrane|inward rectifier potassium channel complex KCNK12 12.97174095 11.16451565 14.77896625 1.323744505 0.404624696 0.799654428 1 0.041687064 0.057560082 56660 potassium two pore domain channel subfamily K member 12 "GO:0005244,GO:0005887,GO:0022841,GO:0030322,GO:0034765,GO:0071805" voltage-gated ion channel activity|integral component of plasma membrane|potassium ion leak channel activity|stabilization of membrane potential|regulation of ion transmembrane transport|potassium ion transmembrane transport KCNK2 7.493403555 7.104691779 7.882115332 1.109423966 0.149810797 1 1 0.056701477 0.065615712 3776 potassium two pore domain channel subfamily K member 2 "GO:0003231,GO:0005634,GO:0005789,GO:0005886,GO:0005887,GO:0007186,GO:0007613,GO:0008076,GO:0009612,GO:0009986,GO:0010942,GO:0015271,GO:0016324,GO:0022841,GO:0030322,GO:0043025,GO:0044305,GO:0048678,GO:0060044,GO:0071456,GO:0071805,GO:0090102,GO:0097449,GO:1900039,GO:2000279" cardiac ventricle development|nucleus|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|memory|voltage-gated potassium channel complex|response to mechanical stimulus|cell surface|positive regulation of cell death|outward rectifier potassium channel activity|apical plasma membrane|potassium ion leak channel activity|stabilization of membrane potential|neuronal cell body|calyx of Held|response to axon injury|negative regulation of cardiac muscle cell proliferation|cellular response to hypoxia|potassium ion transmembrane transport|cochlea development|astrocyte projection|positive regulation of cellular response to hypoxia|negative regulation of DNA biosynthetic process "hsa04927,hsa04934,hsa04971" Cortisol synthesis and secretion|Cushing syndrome|Gastric acid secretion KCNK3 533.2866163 859.6677052 206.9055275 0.240680819 -2.054806923 8.87E-07 0.000400697 6.949582848 1.744681465 3777 potassium two pore domain channel subfamily K member 3 "GO:0005216,GO:0005252,GO:0005267,GO:0005886,GO:0005887,GO:0006813,GO:0007268,GO:0007420,GO:0008022,GO:0022841,GO:0030322,GO:0034220,GO:0042493,GO:0044548,GO:0045202,GO:0051481,GO:0061337,GO:0071294,GO:0071456,GO:0071805,GO:0090102" ion channel activity|open rectifier potassium channel activity|potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|chemical synaptic transmission|brain development|protein C-terminus binding|potassium ion leak channel activity|stabilization of membrane potential|ion transmembrane transport|response to drug|S100 protein binding|synapse|negative regulation of cytosolic calcium ion concentration|cardiac conduction|cellular response to zinc ion|cellular response to hypoxia|potassium ion transmembrane transport|cochlea development "hsa04925,hsa04927,hsa04934" Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome KCNK6 151.4944255 152.2433953 150.7454557 0.99016089 -0.014265129 0.993468207 1 2.652422046 2.739455985 9424 potassium two pore domain channel subfamily K member 6 "GO:0003085,GO:0005242,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0022841,GO:0030322,GO:0034765,GO:0060075,GO:0061337,GO:0071805" negative regulation of systemic arterial blood pressure|inward rectifier potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium ion leak channel activity|stabilization of membrane potential|regulation of ion transmembrane transport|regulation of resting membrane potential|cardiac conduction|potassium ion transmembrane transport KCNK9 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.009620801 0.038966621 51305 potassium two pore domain channel subfamily K member 9 "GO:0005249,GO:0005267,GO:0005886,GO:0005887,GO:0006813,GO:0008021,GO:0022841,GO:0030322,GO:0071805,GO:1990573" voltage-gated potassium channel activity|potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|synaptic vesicle|potassium ion leak channel activity|stabilization of membrane potential|potassium ion transmembrane transport|potassium ion import across plasma membrane hsa04925 Aldosterone synthesis and secretion KCNMA1 6.060044258 10.14955968 1.970528833 0.194149194 -2.364762376 0.199637567 1 0.014001945 0.002835567 3778 potassium calcium-activated channel subfamily M alpha 1 "GO:0001666,GO:0003779,GO:0005249,GO:0005515,GO:0005886,GO:0005901,GO:0006813,GO:0006970,GO:0008076,GO:0015269,GO:0016021,GO:0016324,GO:0030007,GO:0034465,GO:0034765,GO:0042391,GO:0043065,GO:0045211,GO:0045794,GO:0046872,GO:0051592,GO:0060072,GO:0060073,GO:0060083,GO:0060087,GO:0071805" response to hypoxia|actin binding|voltage-gated potassium channel activity|protein binding|plasma membrane|caveola|potassium ion transport|response to osmotic stress|voltage-gated potassium channel complex|calcium-activated potassium channel activity|integral component of membrane|apical plasma membrane|cellular potassium ion homeostasis|response to carbon monoxide|regulation of ion transmembrane transport|regulation of membrane potential|positive regulation of apoptotic process|postsynaptic membrane|negative regulation of cell volume|metal ion binding|response to calcium ion|large conductance calcium-activated potassium channel activity|micturition|smooth muscle contraction involved in micturition|relaxation of vascular associated smooth muscle|potassium ion transmembrane transport "hsa04022,hsa04270,hsa04911,hsa04924,hsa04970,hsa04972" cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion|Renin secretion|Salivary secretion|Pancreatic secretion KCNMB3 31.01826174 32.47859099 29.5579325 0.910074347 -0.135943686 0.922810365 1 0.514039392 0.487965597 27094 potassium calcium-activated channel subfamily M regulatory beta subunit 3 "GO:0001508,GO:0005513,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0015269,GO:0015459,GO:0019228,GO:0071805" action potential|detection of calcium ion|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|calcium-activated potassium channel activity|potassium channel regulator activity|neuronal action potential|potassium ion transmembrane transport "hsa04022,hsa04270,hsa04911" cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion KCNMB4 163.7332802 180.6621624 146.8043981 0.812590728 -0.299399192 0.607682884 1 0.978913147 0.829720755 27345 potassium calcium-activated channel subfamily M regulatory beta subunit 4 "GO:0001508,GO:0005513,GO:0005515,GO:0005886,GO:0005887,GO:0006813,GO:0007268,GO:0008076,GO:0015269,GO:0015459,GO:0019228,GO:0019229,GO:0045202,GO:0046928,GO:0071805" action potential|detection of calcium ion|protein binding|plasma membrane|integral component of plasma membrane|potassium ion transport|chemical synaptic transmission|voltage-gated potassium channel complex|calcium-activated potassium channel activity|potassium channel regulator activity|neuronal action potential|regulation of vasoconstriction|synapse|regulation of neurotransmitter secretion|potassium ion transmembrane transport "hsa04022,hsa04270,hsa04911" cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion KCNN3 36.22665357 51.76275439 20.69055275 0.399718929 -1.3229422 0.159892712 1 0.195890376 0.081673985 3782 potassium calcium-activated channel subfamily N member 3 "GO:0005516,GO:0005886,GO:0006811,GO:0016021,GO:0016286,GO:0043005,GO:0043025,GO:0071805" calmodulin binding|plasma membrane|ion transport|integral component of membrane|small conductance calcium-activated potassium channel activity|neuron projection|neuronal cell body|potassium ion transmembrane transport "hsa04911,hsa04929" Insulin secretion|GnRH secretion KCNN4 137.5468227 209.0809295 66.01271591 0.315728058 -1.663245618 0.00753532 0.355866655 5.413707303 1.782887254 3783 potassium calcium-activated channel subfamily N member 4 "GO:0002376,GO:0005267,GO:0005515,GO:0005516,GO:0005886,GO:0006811,GO:0006813,GO:0006816,GO:0006884,GO:0006952,GO:0008076,GO:0015269,GO:0016286,GO:0019903,GO:0022894,GO:0030322,GO:0031982,GO:0043005,GO:0043025,GO:0045332,GO:0046541,GO:0050714,GO:0050862,GO:0071805" immune system process|potassium channel activity|protein binding|calmodulin binding|plasma membrane|ion transport|potassium ion transport|calcium ion transport|cell volume homeostasis|defense response|voltage-gated potassium channel complex|calcium-activated potassium channel activity|small conductance calcium-activated potassium channel activity|protein phosphatase binding|Intermediate conductance calcium-activated potassium channel activity|stabilization of membrane potential|vesicle|neuron projection|neuronal cell body|phospholipid translocation|saliva secretion|positive regulation of protein secretion|positive regulation of T cell receptor signaling pathway|potassium ion transmembrane transport "hsa04911,hsa04929,hsa04970,hsa04974" Insulin secretion|GnRH secretion|Salivary secretion|Protein digestion and absorption KCNQ4 39.28636725 58.86744617 19.70528833 0.33473999 -1.578887181 0.087756832 1 0.683813871 0.238759925 9132 potassium voltage-gated channel subfamily Q member 4 "GO:0005249,GO:0005251,GO:0005267,GO:0005515,GO:0005516,GO:0005886,GO:0006813,GO:0007605,GO:0008076,GO:0009925,GO:0016021,GO:0034765,GO:0042472,GO:0071805" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|potassium channel activity|protein binding|calmodulin binding|plasma membrane|potassium ion transport|sensory perception of sound|voltage-gated potassium channel complex|basal plasma membrane|integral component of membrane|regulation of ion transmembrane transport|inner ear morphogenesis|potassium ion transmembrane transport hsa04725 Cholinergic synapse KCNRG 10.47888836 9.134603715 11.823173 1.294327961 0.372203218 0.848192439 1 0.322394044 0.435258512 283518 potassium channel regulator "GO:0005515,GO:0005783,GO:0042802,GO:0051260,GO:1902260" protein binding|endoplasmic reticulum|identical protein binding|protein homooligomerization|negative regulation of delayed rectifier potassium channel activity KCNS1 73.02288983 75.10674166 70.93903799 0.944509593 -0.082362645 0.931524131 1 0.577923352 0.569367333 3787 potassium voltage-gated channel modifier subfamily S member 1 "GO:0005249,GO:0005251,GO:0005515,GO:0005886,GO:0006813,GO:0008076,GO:0015459,GO:0016021,GO:0048471,GO:0051260,GO:0071805,GO:1902259" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|protein binding|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium channel regulator activity|integral component of membrane|perinuclear region of cytoplasm|protein homooligomerization|potassium ion transmembrane transport|regulation of delayed rectifier potassium channel activity KCNS3 263.3164936 219.2304892 307.402498 1.402188624 0.487680435 0.323287355 1 3.81292956 5.576749683 3790 potassium voltage-gated channel modifier subfamily S member 3 "GO:0005249,GO:0005251,GO:0005794,GO:0005829,GO:0005886,GO:0006813,GO:0008076,GO:0015459,GO:0016021,GO:0034765,GO:0050796,GO:0051260,GO:0071805" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|Golgi apparatus|cytosol|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium channel regulator activity|integral component of membrane|regulation of ion transmembrane transport|regulation of insulin secretion|protein homooligomerization|potassium ion transmembrane transport KCNT2 31.75114797 15.22433953 48.27795641 3.171103504 1.664984967 0.092094962 1 0.053356798 0.176488376 343450 potassium sodium-activated channel subfamily T member 2 "GO:0005228,GO:0005524,GO:0005886,GO:0015271,GO:0016021,GO:0070089,GO:0097623" intracellular sodium activated potassium channel activity|ATP binding|plasma membrane|outward rectifier potassium channel activity|integral component of membrane|chloride-activated potassium channel activity|potassium ion export across plasma membrane KCTD1 440.7962167 430.3413306 451.2511028 1.048588808 0.068449052 0.87621419 1 5.041700264 5.514398792 284252 potassium channel tetramerization domain containing 1 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0008134,GO:0034451,GO:0042802,GO:0045171,GO:0045892,GO:0051260" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|transcription factor binding|centriolar satellite|identical protein binding|intercellular bridge|negative regulation of transcription, DNA-templated|protein homooligomerization" KCTD10 1859.41541 1867.518982 1851.311839 0.991321564 -0.012574981 0.970862708 1 24.10992817 24.93023658 83892 potassium channel tetramerization domain containing 10 "GO:0004842,GO:0005112,GO:0005515,GO:0005654,GO:0005829,GO:0006511,GO:0016567,GO:0031463,GO:0035024,GO:0042802,GO:0043161,GO:0051260" ubiquitin-protein transferase activity|Notch binding|protein binding|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|Cul3-RING ubiquitin ligase complex|negative regulation of Rho protein signal transduction|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein homooligomerization KCTD11 614.1458464 763.2468882 465.0448046 0.609298003 -0.714780084 0.066549092 1 13.88996131 8.827682813 147040 potassium channel tetramerization domain containing 11 "GO:0007049,GO:0007275,GO:0016567,GO:0016740,GO:0040008,GO:0042802,GO:0045666,GO:0051260" cell cycle|multicellular organism development|protein ubiquitination|transferase activity|regulation of growth|identical protein binding|positive regulation of neuron differentiation|protein homooligomerization KCTD12 237.8102201 327.8307778 147.7896625 0.450810822 -1.149405945 0.025141933 0.704078018 2.664656135 1.253001052 115207 potassium channel tetramerization domain containing 12 "GO:0003723,GO:0005515,GO:0042734,GO:0042802,GO:0042995,GO:0045211,GO:0051260" RNA binding|protein binding|presynaptic membrane|identical protein binding|cell projection|postsynaptic membrane|protein homooligomerization KCTD13 218.4896842 185.7369422 251.2424262 1.352678811 0.435819317 0.406876349 1 1.975828793 2.787789171 253980 potassium channel tetramerization domain containing 13 "GO:0004842,GO:0005515,GO:0005654,GO:0016477,GO:0016567,GO:0016604,GO:0019904,GO:0031267,GO:0031463,GO:0035024,GO:0042802,GO:0043149,GO:0043161,GO:0045740,GO:0050806,GO:0051260,GO:0061351" ubiquitin-protein transferase activity|protein binding|nucleoplasm|cell migration|protein ubiquitination|nuclear body|protein domain specific binding|small GTPase binding|Cul3-RING ubiquitin ligase complex|negative regulation of Rho protein signal transduction|identical protein binding|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of DNA replication|positive regulation of synaptic transmission|protein homooligomerization|neural precursor cell proliferation KCTD15 72.20092894 86.27125731 58.13060058 0.673811909 -0.569582168 0.45446534 1 0.739687631 0.51987983 79047 potassium channel tetramerization domain containing 15 "GO:0005515,GO:0007275,GO:0042802,GO:0051260" protein binding|multicellular organism development|identical protein binding|protein homooligomerization KCTD16 28.59963803 35.52345889 21.67581716 0.610183181 -0.71268568 0.486277701 1 0.105806744 0.067342543 57528 potassium channel tetramerization domain containing 16 "GO:0005515,GO:0008277,GO:0042734,GO:0042995,GO:0043235,GO:0045211,GO:0051260" protein binding|regulation of G protein-coupled receptor signaling pathway|presynaptic membrane|cell projection|receptor complex|postsynaptic membrane|protein homooligomerization KCTD17 574.7246294 526.7621476 622.6871113 1.182102993 0.241355739 0.542587264 1 15.01330584 18.51175434 79734 potassium channel tetramerization domain containing 17 "GO:0005515,GO:0005737,GO:0005783,GO:0030030,GO:0031463,GO:0032469,GO:0042802,GO:0043161,GO:0045724,GO:0051260,GO:0097602" protein binding|cytoplasm|endoplasmic reticulum|cell projection organization|Cul3-RING ubiquitin ligase complex|endoplasmic reticulum calcium ion homeostasis|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of cilium assembly|protein homooligomerization|cullin family protein binding KCTD18 207.8123576 230.3950048 185.2297103 0.803965826 -0.314793917 0.557625835 1 3.970294049 3.329478318 130535 potassium channel tetramerization domain containing 18 GO:0051260 protein homooligomerization KCTD2 1386.154211 1204.752734 1567.555687 1.301143083 0.379779619 0.25701228 1 16.68484438 22.64452145 23510 potassium channel tetramerization domain containing 2 "GO:0005737,GO:0031463,GO:0043161,GO:0044877,GO:0051260,GO:0097602" cytoplasm|Cul3-RING ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|protein homooligomerization|cullin family protein binding KCTD20 1331.17512 1184.453615 1477.896625 1.247745463 0.319323658 0.343313545 1 10.09395879 13.13721951 222658 potassium channel tetramerization domain containing 20 "GO:0005737,GO:0042327,GO:0042802" cytoplasm|positive regulation of phosphorylation|identical protein binding KCTD21 461.5488741 400.9076075 522.1901408 1.30251991 0.381305425 0.361199209 1 2.480703238 3.370350857 283219 potassium channel tetramerization domain containing 21 "GO:0005515,GO:0006511,GO:0016567,GO:0040008,GO:0042802,GO:0042826,GO:0045879,GO:0051260,GO:0097602" protein binding|ubiquitin-dependent protein catabolic process|protein ubiquitination|regulation of growth|identical protein binding|histone deacetylase binding|negative regulation of smoothened signaling pathway|protein homooligomerization|cullin family protein binding KCTD3 1710.667699 1532.583512 1888.751887 1.232397368 0.301467506 0.356191216 1 18.9733435 24.38993041 51133 potassium channel tetramerization domain containing 3 "GO:0005886,GO:0051260" plasma membrane|protein homooligomerization KCTD5 771.8475362 767.3067121 776.3883602 1.011835747 0.016975114 0.967239058 1 15.96605508 16.85091824 54442 potassium channel tetramerization domain containing 5 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016032,GO:0031463,GO:0042802,GO:0043161,GO:0044877,GO:0051260,GO:0097602" protein binding|nucleus|cytoplasm|cytosol|viral process|Cul3-RING ubiquitin ligase complex|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|protein homooligomerization|cullin family protein binding KCTD6 160.3914968 154.2733072 166.5096864 1.079316244 0.110117642 0.859003501 1 2.358405906 2.655114146 200845 potassium channel tetramerization domain containing 6 "GO:0005515,GO:0005829,GO:0006511,GO:0016567,GO:0030506,GO:0031430,GO:0033146,GO:0040008,GO:0042802,GO:0043687,GO:0045879,GO:0051260,GO:0097602" protein binding|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|ankyrin binding|M band|regulation of intracellular estrogen receptor signaling pathway|regulation of growth|identical protein binding|post-translational protein modification|negative regulation of smoothened signaling pathway|protein homooligomerization|cullin family protein binding KCTD7 268.240094 252.7240361 283.756152 1.12279052 0.167088788 0.738325597 1 2.534068674 2.96778918 154881 potassium channel tetramerization domain containing 7 "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0032411,GO:0043687,GO:0051260,GO:0060081,GO:0090461" protein binding|cytoplasm|cytosol|plasma membrane|positive regulation of transporter activity|post-translational protein modification|protein homooligomerization|membrane hyperpolarization|glutamate homeostasis KCTD9 797.5683314 774.4114039 820.725259 1.059805234 0.083799157 0.822472566 1 11.64870973 12.87715173 54793 potassium channel tetramerization domain containing 9 "GO:0005515,GO:0016567,GO:0035556,GO:0042802,GO:0043621,GO:0051260,GO:0097602" protein binding|protein ubiquitination|intracellular signal transduction|identical protein binding|protein self-association|protein homooligomerization|cullin family protein binding KDELR1 4890.643008 4599.780449 5181.505567 1.126468018 0.171806354 0.59240495 1 150.2984856 176.5994719 10945 KDEL endoplasmic reticulum protein retention receptor 1 "GO:0000139,GO:0005046,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005801,GO:0006621,GO:0006888,GO:0006890,GO:0015031,GO:0016021,GO:0030133,GO:0030663,GO:0033116,GO:0046923" "Golgi membrane|KDEL sequence binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cis-Golgi network|protein retention in ER lumen|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|integral component of membrane|transport vesicle|COPI-coated vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|ER retention sequence binding" hsa05110 Vibrio cholerae infection KDELR2 6226.401267 6333.325243 6119.477291 0.966234491 -0.049554743 0.87924645 1 115.1330154 116.0374951 11014 KDEL endoplasmic reticulum protein retention receptor 2 "GO:0000139,GO:0005046,GO:0005783,GO:0005789,GO:0005801,GO:0006621,GO:0006888,GO:0006890,GO:0015031,GO:0016021,GO:0030133,GO:0030663,GO:0046923" "Golgi membrane|KDEL sequence binding|endoplasmic reticulum|endoplasmic reticulum membrane|cis-Golgi network|protein retention in ER lumen|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|integral component of membrane|transport vesicle|COPI-coated vesicle membrane|ER retention sequence binding" hsa05110 Vibrio cholerae infection KDELR3 1317.313624 1651.333361 983.2938877 0.595454504 -0.747936812 0.027109242 0.726163375 44.84407998 27.85284953 11015 KDEL endoplasmic reticulum protein retention receptor 3 "GO:0000139,GO:0005046,GO:0005783,GO:0005789,GO:0005801,GO:0006621,GO:0006888,GO:0006890,GO:0015031,GO:0016021,GO:0030133,GO:0030663,GO:0036498,GO:0046923" "Golgi membrane|KDEL sequence binding|endoplasmic reticulum|endoplasmic reticulum membrane|cis-Golgi network|protein retention in ER lumen|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|integral component of membrane|transport vesicle|COPI-coated vesicle membrane|IRE1-mediated unfolded protein response|ER retention sequence binding" hsa05110 Vibrio cholerae infection KDM1A 1773.994322 1887.818101 1660.170542 0.879412344 -0.185388311 0.569474954 1 24.78261457 22.73294021 23028 lysine demethylase 1A "GO:0000122,GO:0000380,GO:0000781,GO:0000785,GO:0001085,GO:0002039,GO:0002052,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006482,GO:0007596,GO:0008134,GO:0010569,GO:0010976,GO:0016491,GO:0019899,GO:0021987,GO:0030374,GO:0032091,GO:0032451,GO:0032452,GO:0032453,GO:0032454,GO:0032991,GO:0033169,GO:0033184,GO:0034644,GO:0034648,GO:0034720,GO:0035563,GO:0042162,GO:0042551,GO:0043392,GO:0043426,GO:0043433,GO:0043518,GO:0045793,GO:0045892,GO:0045944,GO:0046098,GO:0050660,GO:0050681,GO:0051091,GO:0051572,GO:0051573,GO:0055001,GO:0055114,GO:0060992,GO:0061752,GO:0071320,GO:0071480,GO:0120162,GO:1902166,GO:1903827,GO:1990391,GO:1990841,GO:2000179,GO:2000648" "negative regulation of transcription by RNA polymerase II|alternative mRNA splicing, via spliceosome|chromosome, telomeric region|chromatin|RNA polymerase II transcription factor binding|p53 binding|positive regulation of neuroblast proliferation|chromatin binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|protein demethylation|blood coagulation|transcription factor binding|regulation of double-strand break repair via homologous recombination|positive regulation of neuron projection development|oxidoreductase activity|enzyme binding|cerebral cortex development|nuclear receptor coactivator activity|negative regulation of protein binding|demethylase activity|histone demethylase activity|histone demethylase activity (H3-K4 specific)|histone demethylase activity (H3-K9 specific)|protein-containing complex|histone H3-K9 demethylation|positive regulation of histone ubiquitination|cellular response to UV|histone demethylase activity (H3-dimethyl-K4 specific)|histone H3-K4 demethylation|positive regulation of chromatin binding|telomeric DNA binding|neuron maturation|negative regulation of DNA binding|MRF binding|negative regulation of DNA-binding transcription factor activity|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of cell size|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|guanine metabolic process|flavin adenine dinucleotide binding|androgen receptor binding|positive regulation of DNA-binding transcription factor activity|negative regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|muscle cell development|oxidation-reduction process|response to fungicide|telomeric repeat-containing RNA binding|cellular response to cAMP|cellular response to gamma radiation|positive regulation of cold-induced thermogenesis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of cellular protein localization|DNA repair complex|promoter-specific chromatin binding|positive regulation of neural precursor cell proliferation|positive regulation of stem cell proliferation" hsa04714 Thermogenesis other KDM1B 239.7065201 322.7559979 156.6570422 0.485372985 -1.042834281 0.041219116 0.932694318 3.55357667 1.799107941 221656 lysine demethylase 1B "GO:0000122,GO:0000786,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006349,GO:0007275,GO:0008134,GO:0008270,GO:0016491,GO:0016579,GO:0034648,GO:0034649,GO:0034720,GO:0042393,GO:0044030,GO:0045944,GO:0050660,GO:0055114,GO:0071949" negative regulation of transcription by RNA polymerase II|nucleosome|chromatin binding|protein binding|nucleus|nucleoplasm|regulation of gene expression by genetic imprinting|multicellular organism development|transcription factor binding|zinc ion binding|oxidoreductase activity|protein deubiquitination|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|histone H3-K4 demethylation|histone binding|regulation of DNA methylation|positive regulation of transcription by RNA polymerase II|flavin adenine dinucleotide binding|oxidation-reduction process|FAD binding KDM2A 4236.932438 4263.830023 4210.034852 0.987383369 -0.01831775 0.955002268 1 26.73946865 27.53940231 22992 lysine demethylase 2A "GO:0003712,GO:0005515,GO:0005654,GO:0006303,GO:0006357,GO:0006482,GO:0008270,GO:0010944,GO:0032452,GO:0032922,GO:0042752,GO:0045322,GO:0051864,GO:0055114,GO:0070544" transcription coregulator activity|protein binding|nucleoplasm|double-strand break repair via nonhomologous end joining|regulation of transcription by RNA polymerase II|protein demethylation|zinc ion binding|negative regulation of transcription by competitive promoter binding|histone demethylase activity|circadian regulation of gene expression|regulation of circadian rhythm|unmethylated CpG binding|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation KDM2B 1369.048171 1550.85272 1187.243622 0.76554247 -0.385445678 0.250759077 1 9.798555286 7.824331932 84678 lysine demethylase 2B "GO:0000122,GO:0000978,GO:0003677,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0006482,GO:0007283,GO:0008270,GO:0019843,GO:0021555,GO:0021592,GO:0021670,GO:0021678,GO:0021993,GO:0030307,GO:0030900,GO:0030901,GO:0030902,GO:0031519,GO:0032452,GO:0035518,GO:0043524,GO:0045322,GO:0048596,GO:0051864,GO:0055114,GO:0070544,GO:1902459,GO:2000178" negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|protein demethylation|spermatogenesis|zinc ion binding|rRNA binding|midbrain-hindbrain boundary morphogenesis|fourth ventricle development|lateral ventricle development|third ventricle development|initiation of neural tube closure|positive regulation of cell growth|forebrain development|midbrain development|hindbrain development|PcG protein complex|histone demethylase activity|histone H2A monoubiquitination|negative regulation of neuron apoptotic process|unmethylated CpG binding|embryonic camera-type eye morphogenesis|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation|positive regulation of stem cell population maintenance|negative regulation of neural precursor cell proliferation other KDM3A 1101.856684 1437.177651 766.5357161 0.53336184 -0.906813486 0.009292951 0.405005328 14.0761899 7.831103919 55818 lysine demethylase 3A "GO:0000118,GO:0000785,GO:0003712,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007290,GO:0009755,GO:0016020,GO:0030521,GO:0031490,GO:0032454,GO:0033169,GO:0036123,GO:0045893,GO:0045944,GO:0046293,GO:0050681,GO:0051213,GO:0051573,GO:0055114,GO:0120162,GO:1990830,GO:2000036,GO:2000736" "histone deacetylase complex|chromatin|transcription coregulator activity|iron ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|spermatid nucleus elongation|hormone-mediated signaling pathway|membrane|androgen receptor signaling pathway|chromatin DNA binding|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|histone H3-K9 dimethylation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|formaldehyde biosynthetic process|androgen receptor binding|dioxygenase activity|negative regulation of histone H3-K9 methylation|oxidation-reduction process|positive regulation of cold-induced thermogenesis|cellular response to leukemia inhibitory factor|regulation of stem cell population maintenance|regulation of stem cell differentiation" hsa04714 Thermogenesis KDM3B 2560.11087 2317.144476 2803.077265 1.209711908 0.274663512 0.389198076 1 15.22709138 19.21386963 51780 lysine demethylase 3B "GO:0000118,GO:0000785,GO:0003712,GO:0005654,GO:0006357,GO:0016209,GO:0031490,GO:0032454,GO:0033169,GO:0046872,GO:0051213,GO:0055114,GO:0072718,GO:0098869" histone deacetylase complex|chromatin|transcription coregulator activity|nucleoplasm|regulation of transcription by RNA polymerase II|antioxidant activity|chromatin DNA binding|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|metal ion binding|dioxygenase activity|oxidation-reduction process|response to cisplatin|cellular oxidant detoxification hsa04714 Thermogenesis KDM4A 1535.934445 1509.239525 1562.629365 1.035375326 0.050153842 0.88121297 1 16.29453372 17.59769061 9682 lysine demethylase 4A "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006338,GO:0008270,GO:0010507,GO:0010629,GO:0016032,GO:0016577,GO:0031625,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0035097,GO:0045892,GO:0051864,GO:0055114,GO:0070544" "fibrillar center|protein binding|nucleus|nucleoplasm|cytosol|chromatin remodeling|zinc ion binding|negative regulation of autophagy|negative regulation of gene expression|viral process|histone demethylation|ubiquitin protein ligase binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|histone methyltransferase complex|negative regulation of transcription, DNA-templated|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation" chromosome_remodelling_factor KDM4B 787.49696 894.1762081 680.8177118 0.761390994 -0.39329059 0.286052415 1 5.072454131 4.028485397 23030 lysine demethylase 4B "GO:0005654,GO:0006338,GO:0032452,GO:0032454,GO:0033169,GO:0035097,GO:0046872,GO:0051864,GO:0055114,GO:0070544" nucleoplasm|chromatin remodeling|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|histone methyltransferase complex|metal ion binding|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation KDM4C 392.340111 418.161859 366.518363 0.876498789 -0.190175997 0.665934219 1 1.81726643 1.66144456 23081 lysine demethylase 4C "GO:0000785,GO:0003682,GO:0005654,GO:0006338,GO:0006357,GO:0008270,GO:0008284,GO:0010628,GO:0019899,GO:0032452,GO:0032454,GO:0033169,GO:0035097,GO:0045666,GO:0050681,GO:0051864,GO:0055114,GO:0070544" chromatin|chromatin binding|nucleoplasm|chromatin remodeling|regulation of transcription by RNA polymerase II|zinc ion binding|positive regulation of cell population proliferation|positive regulation of gene expression|enzyme binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|histone methyltransferase complex|positive regulation of neuron differentiation|androgen receptor binding|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation other KDM4D 48.40884679 42.62815067 54.18954291 1.271214961 0.346208009 0.700932002 1 0.731604693 0.970088615 55693 lysine demethylase 4D "GO:0000724,GO:0001932,GO:0003684,GO:0005515,GO:0005654,GO:0005721,GO:0006338,GO:0031490,GO:0032452,GO:0032454,GO:0033169,GO:0035097,GO:0035563,GO:0035861,GO:0046872,GO:0051213,GO:0055114,GO:0071479,GO:0072562,GO:1900113,GO:2001034" double-strand break repair via homologous recombination|regulation of protein phosphorylation|damaged DNA binding|protein binding|nucleoplasm|pericentric heterochromatin|chromatin remodeling|chromatin DNA binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|histone methyltransferase complex|positive regulation of chromatin binding|site of double-strand break|metal ion binding|dioxygenase activity|oxidation-reduction process|cellular response to ionizing radiation|blood microparticle|negative regulation of histone H3-K9 trimethylation|positive regulation of double-strand break repair via nonhomologous end joining KDM5A 2356.751008 2222.753571 2490.748445 1.120568865 0.164231312 0.607752528 1 10.52000999 12.29619193 5927 lysine demethylase 5A "GO:0000976,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006338,GO:0007283,GO:0008270,GO:0008584,GO:0032452,GO:0032922,GO:0034647,GO:0034648,GO:0034720,GO:0034721,GO:0035064,GO:0035097,GO:0042393,GO:0045893,GO:0051090,GO:0051213,GO:0055114,GO:1901726" "transcription regulatory region sequence-specific DNA binding|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleolus|chromatin remodeling|spermatogenesis|zinc ion binding|male gonad development|histone demethylase activity|circadian regulation of gene expression|histone demethylase activity (H3-trimethyl-K4 specific)|histone demethylase activity (H3-dimethyl-K4 specific)|histone H3-K4 demethylation|histone H3-K4 demethylation, trimethyl-H3-K4-specific|methylated histone binding|histone methyltransferase complex|histone binding|positive regulation of transcription, DNA-templated|regulation of DNA-binding transcription factor activity|dioxygenase activity|oxidation-reduction process|negative regulation of histone deacetylase activity" ARID KDM5B 2404.139209 2700.797832 2107.480587 0.780317787 -0.357866309 0.262624863 1 12.60931806 10.26311123 10765 lysine demethylase 5B "GO:0003677,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006338,GO:0006357,GO:0007338,GO:0008270,GO:0009791,GO:0010628,GO:0032452,GO:0032453,GO:0033601,GO:0034647,GO:0034648,GO:0034720,GO:0034721,GO:0035097,GO:0042393,GO:0044344,GO:0045892,GO:0048511,GO:0051213,GO:0055114,GO:0060444,GO:0060763,GO:0060992,GO:0061038,GO:0070306,GO:1990830,GO:1990837,GO:2000864" "DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|chromatin remodeling|regulation of transcription by RNA polymerase II|single fertilization|zinc ion binding|post-embryonic development|positive regulation of gene expression|histone demethylase activity|histone demethylase activity (H3-K4 specific)|positive regulation of mammary gland epithelial cell proliferation|histone demethylase activity (H3-trimethyl-K4 specific)|histone demethylase activity (H3-dimethyl-K4 specific)|histone H3-K4 demethylation|histone H3-K4 demethylation, trimethyl-H3-K4-specific|histone methyltransferase complex|histone binding|cellular response to fibroblast growth factor stimulus|negative regulation of transcription, DNA-templated|rhythmic process|dioxygenase activity|oxidation-reduction process|branching involved in mammary gland duct morphogenesis|mammary duct terminal end bud growth|response to fungicide|uterus morphogenesis|lens fiber cell differentiation|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding|regulation of estradiol secretion" ARID KDM5C 4430.585392 4401.864035 4459.306749 1.013049634 0.01870486 0.954061579 1 34.52135096 36.47828708 8242 lysine demethylase 5C "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006338,GO:0008270,GO:0009636,GO:0032452,GO:0032453,GO:0034647,GO:0034720,GO:0034721,GO:0035097,GO:0045892,GO:0048511,GO:0051213,GO:0055114" "DNA binding|protein binding|nucleus|nucleoplasm|cytosol|chromatin remodeling|zinc ion binding|response to toxic substance|histone demethylase activity|histone demethylase activity (H3-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|histone H3-K4 demethylation|histone H3-K4 demethylation, trimethyl-H3-K4-specific|histone methyltransferase complex|negative regulation of transcription, DNA-templated|rhythmic process|dioxygenase activity|oxidation-reduction process" ARID KDM6A 320.7505804 340.0102494 301.4909115 0.886711245 -0.173463724 0.712233669 1 2.748215711 2.541844413 7403 lysine demethylase 6A "GO:0000978,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0007507,GO:0010468,GO:0031490,GO:0035097,GO:0044666,GO:0046872,GO:0051213,GO:0051568,GO:0055114,GO:0071557,GO:0071558" RNA polymerase II cis-regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|chromatin remodeling|heart development|regulation of gene expression|chromatin DNA binding|histone methyltransferase complex|MLL3/4 complex|metal ion binding|dioxygenase activity|histone H3-K4 methylation|oxidation-reduction process|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific) hsa05202 Transcriptional misregulation in cancer KDM6B 838.3231927 765.2768002 911.3695853 1.190901887 0.252054561 0.489434864 1 4.031891209 5.008419737 23135 lysine demethylase 6B "GO:0000978,GO:0002437,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0007507,GO:0008013,GO:0010468,GO:0014823,GO:0021766,GO:0031490,GO:0044666,GO:0045165,GO:0045446,GO:0045944,GO:0046872,GO:0048333,GO:0051213,GO:0055007,GO:0055114,GO:0060992,GO:0070301,GO:0071557,GO:0071558,GO:0120162" RNA polymerase II cis-regulatory region sequence-specific DNA binding|inflammatory response to antigenic stimulus|protein binding|nucleus|nucleoplasm|chromatin remodeling|heart development|beta-catenin binding|regulation of gene expression|response to activity|hippocampus development|chromatin DNA binding|MLL3/4 complex|cell fate commitment|endothelial cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|mesodermal cell differentiation|dioxygenase activity|cardiac muscle cell differentiation|oxidation-reduction process|response to fungicide|cellular response to hydrogen peroxide|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific)|positive regulation of cold-induced thermogenesis KDM7A 286.8656001 313.6213942 260.109806 0.829375198 -0.26990319 0.576497624 1 1.734419876 1.500448921 80853 lysine demethylase 7A "GO:0003712,GO:0005506,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0006482,GO:0008270,GO:0016706,GO:0030901,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0035574,GO:0035575,GO:0045893,GO:0051864,GO:0055114,GO:0070544,GO:0071557,GO:0071558" "transcription coregulator activity|iron ion binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|protein demethylation|zinc ion binding|2-oxoglutarate-dependent dioxygenase activity|midbrain development|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|histone H4-K20 demethylation|histone demethylase activity (H4-K20 specific)|positive regulation of transcription, DNA-templated|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific)" KDM8 41.09359255 47.70293051 34.48425458 0.722895935 -0.468140116 0.615550377 1 0.735459709 0.554562627 79831 lysine demethylase 8 "GO:0000086,GO:0003682,GO:0004175,GO:0004177,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006508,GO:0016706,GO:0031648,GO:0032922,GO:0035064,GO:0045892,GO:0045893,GO:0046872,GO:0051864,GO:0055114,GO:0070544,GO:0140554" "G2/M transition of mitotic cell cycle|chromatin binding|endopeptidase activity|aminopeptidase activity|protein binding|nucleus|nucleoplasm|chromosome|cytosol|proteolysis|2-oxoglutarate-dependent dioxygenase activity|protein destabilization|circadian regulation of gene expression|methylated histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation|L-arginine 3-hydroxylase activity" KDR 5.478337395 4.059823873 6.896850916 1.698805448 0.764520641 0.742562249 1 0.03525043 0.062463166 3791 kinase insert domain receptor "GO:0001525,GO:0001569,GO:0001570,GO:0001934,GO:0001938,GO:0002042,GO:0002244,GO:0003158,GO:0004713,GO:0004714,GO:0005021,GO:0005178,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005768,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0008284,GO:0008360,GO:0010595,GO:0010629,GO:0014068,GO:0016032,GO:0016239,GO:0016477,GO:0018108,GO:0019838,GO:0030054,GO:0030198,GO:0030335,GO:0033674,GO:0035162,GO:0035584,GO:0035924,GO:0036324,GO:0038033,GO:0038083,GO:0038084,GO:0038085,GO:0042802,GO:0043066,GO:0043235,GO:0043410,GO:0043491,GO:0043536,GO:0045121,GO:0045296,GO:0045446,GO:0045766,GO:0046777,GO:0048010,GO:0050927,GO:0051770,GO:0051879,GO:0051894,GO:0051901,GO:0061042,GO:0070371,GO:0070374,GO:0090050,GO:0090141,GO:0097443,GO:1904881,GO:2000352,GO:2001214" angiogenesis|branching involved in blood vessel morphogenesis|vasculogenesis|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|hematopoietic progenitor cell differentiation|endothelium development|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|vascular endothelial growth factor-activated receptor activity|integrin binding|protein binding|ATP binding|extracellular region|nucleus|endosome|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|positive regulation of cell population proliferation|regulation of cell shape|positive regulation of endothelial cell migration|negative regulation of gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|positive regulation of macroautophagy|cell migration|peptidyl-tyrosine phosphorylation|growth factor binding|cell junction|extracellular matrix organization|positive regulation of cell migration|positive regulation of kinase activity|embryonic hemopoiesis|calcium-mediated signaling using intracellular calcium source|cellular response to vascular endothelial growth factor stimulus|vascular endothelial growth factor receptor-2 signaling pathway|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|peptidyl-tyrosine autophosphorylation|vascular endothelial growth factor signaling pathway|vascular endothelial growth factor binding|identical protein binding|negative regulation of apoptotic process|receptor complex|positive regulation of MAPK cascade|protein kinase B signaling|positive regulation of blood vessel endothelial cell migration|membrane raft|cadherin binding|endothelial cell differentiation|positive regulation of angiogenesis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|Hsp90 protein binding|positive regulation of focal adhesion assembly|positive regulation of mitochondrial depolarization|vascular wound healing|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of mitochondrial fission|sorting endosome|cellular response to hydrogen sulfide|negative regulation of endothelial cell apoptotic process|positive regulation of vasculogenesis "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04370,hsa04510,hsa05205,hsa05418" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|VEGF signaling pathway|Focal adhesion|Proteoglycans in cancer|Fluid shear stress and atherosclerosis KDSR 2122.926383 1897.967661 2347.885105 1.237052218 0.3069064 0.339210318 1 17.04955062 21.9997071 2531 3-ketodihydrosphingosine reductase "GO:0005515,GO:0005615,GO:0005783,GO:0005789,GO:0006666,GO:0016020,GO:0016021,GO:0030148,GO:0047560,GO:0055114" protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|3-keto-sphinganine metabolic process|membrane|integral component of membrane|sphingolipid biosynthetic process|3-dehydrosphinganine reductase activity|oxidation-reduction process hsa00600 Sphingolipid metabolism KEAP1 1388.464708 1430.072959 1346.856457 0.941809611 -0.08649265 0.79779997 1 23.8879124 23.46698228 9817 kelch like ECH associated protein 1 "GO:0001701,GO:0005515,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0005884,GO:0006511,GO:0008134,GO:0010506,GO:0016032,GO:0016234,GO:0016567,GO:0016579,GO:0030496,GO:0031463,GO:0032436,GO:0034451,GO:0034599,GO:0042802,GO:0042994,GO:0043433,GO:0043687,GO:0045604,GO:0071353,GO:0097718" in utero embryonic development|protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|actin filament|ubiquitin-dependent protein catabolic process|transcription factor binding|regulation of autophagy|viral process|inclusion body|protein ubiquitination|protein deubiquitination|midbody|Cul3-RING ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|centriolar satellite|cellular response to oxidative stress|identical protein binding|cytoplasmic sequestering of transcription factor|negative regulation of DNA-binding transcription factor activity|post-translational protein modification|regulation of epidermal cell differentiation|cellular response to interleukin-4|disordered domain specific binding "hsa04120,hsa05200,hsa05225,hsa05418" Ubiquitin mediated proteolysis|Pathways in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis KEL 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.059062358 0.119608572 3792 Kell metallo-endopeptidase (Kell blood group) "GO:0004222,GO:0005515,GO:0005654,GO:0005886,GO:0006874,GO:0008361,GO:0010961,GO:0016021,GO:0016485,GO:0031133,GO:0042310,GO:0042552,GO:0046872,GO:0048741,GO:1901380" metalloendopeptidase activity|protein binding|nucleoplasm|plasma membrane|cellular calcium ion homeostasis|regulation of cell size|cellular magnesium ion homeostasis|integral component of membrane|protein processing|regulation of axon diameter|vasoconstriction|myelination|metal ion binding|skeletal muscle fiber development|negative regulation of potassium ion transmembrane transport KHDC1 63.30657925 50.74779842 75.86536007 1.494948795 0.58009607 0.466311816 1 1.430270986 2.230286091 80759 KH domain containing 1 "GO:0003723,GO:0005737,GO:0006919,GO:0016021" RNA binding|cytoplasm|activation of cysteine-type endopeptidase activity involved in apoptotic process|integral component of membrane KHDC4 1134.856607 965.2231259 1304.490088 1.35149071 0.434551595 0.208076679 1 16.50967451 23.27381113 22889 "KH domain containing 4, pre-mRNA splicing factor" "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006376" RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|mRNA splice site selection KHDRBS1 4550.871282 4474.940865 4626.8017 1.033935831 0.04814665 0.880943472 1 83.5385065 90.09407327 10657 "KH RNA binding domain containing, signal transduction associated 1" "GO:0000082,GO:0000086,GO:0000122,GO:0000381,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0007283,GO:0008143,GO:0008266,GO:0016020,GO:0017124,GO:0019904,GO:0031647,GO:0032991,GO:0035591,GO:0042169,GO:0042802,GO:0044877,GO:0045892,GO:0045948,GO:0046831,GO:0046833,GO:0048024,GO:0050852,GO:0070618,GO:1990782" "G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|regulation of alternative mRNA splicing, via spliceosome|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|spermatogenesis|poly(A) binding|poly(U) RNA binding|membrane|SH3 domain binding|protein domain specific binding|regulation of protein stability|protein-containing complex|signaling adaptor activity|SH2 domain binding|identical protein binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of translational initiation|regulation of RNA export from nucleus|positive regulation of RNA export from nucleus|regulation of mRNA splicing, via spliceosome|T cell receptor signaling pathway|Grb2-Sos complex|protein tyrosine kinase binding" KHDRBS3 29.45129046 26.38885518 32.51372575 1.232100655 0.30112012 0.78802796 1 0.362982732 0.466496171 10656 "KH RNA binding domain containing, signal transduction associated 3" "GO:0000381,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0016032,GO:0017124,GO:0019904,GO:0032991,GO:0042802,GO:0048024" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|viral process|SH3 domain binding|protein domain specific binding|protein-containing complex|identical protein binding|regulation of mRNA splicing, via spliceosome" KHK 140.07481 146.1536594 133.9959607 0.916815639 -0.125296441 0.846545263 1 2.22220572 2.125113859 3795 ketohexokinase "GO:0004454,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006000,GO:0009744,GO:0009749,GO:0009750,GO:0010043,GO:0032868,GO:0046835,GO:0061624,GO:0070062,GO:0070873" ketohexokinase activity|protein binding|ATP binding|cytoplasm|cytosol|fructose metabolic process|response to sucrose|response to glucose|response to fructose|response to zinc ion|response to insulin|carbohydrate phosphorylation|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|extracellular exosome|regulation of glycogen metabolic process hsa00051 Fructose and mannose metabolism KHNYN 2788.929747 2333.383771 3244.475724 1.390459539 0.475561765 0.135697485 1 16.64943031 24.14758278 23351 KH and NYN domain containing "GO:0003674,GO:0003729,GO:0004521,GO:0005515,GO:0005575,GO:0005634,GO:0008150,GO:0036464,GO:0090502" "molecular_function|mRNA binding|endoribonuclease activity|protein binding|cellular_component|nucleus|biological_process|cytoplasmic ribonucleoprotein granule|RNA phosphodiester bond hydrolysis, endonucleolytic" KHSRP 3733.515269 3795.935322 3671.095216 0.967112162 -0.048244877 0.880271463 1 44.96041459 45.3547818 8570 KH-type splicing regulatory protein "GO:0000178,GO:0000375,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006397,GO:0008380,GO:0010468,GO:0010586,GO:0010989,GO:0016020,GO:0035925,GO:0043488,GO:0045019,GO:0051028,GO:0061014,GO:0061158,GO:0071345" "exosome (RNase complex)|RNA splicing, via transesterification reactions|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|mRNA processing|RNA splicing|regulation of gene expression|miRNA metabolic process|negative regulation of low-density lipoprotein particle clearance|membrane|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|negative regulation of nitric oxide biosynthetic process|mRNA transport|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|cellular response to cytokine stimulus" KIAA0040 7.971189988 6.08973581 9.852644165 1.617909951 0.694131313 0.702268135 1 0.064917625 0.109555175 9674 KIAA0040 GO:0016021 integral component of membrane KIAA0100 7748.117917 8285.08557 7211.150265 0.870377283 -0.200287193 0.543750973 1 52.90095261 48.027167 9703 KIAA0100 GO:0005576 extracellular region KIAA0232 756.2641764 745.9926368 766.5357161 1.027537912 0.039191624 0.919583441 1 4.423591541 4.741205756 9778 KIAA0232 GO:0005524 ATP binding KIAA0319 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.018356364 0.012391302 9856 KIAA0319 "GO:0001764,GO:0005515,GO:0005769,GO:0005886,GO:0010996,GO:0016021,GO:0030517,GO:0030665,GO:0031410,GO:0031901,GO:0033555,GO:0043231,GO:0048692,GO:0060391,GO:0061024,GO:2000171" neuron migration|protein binding|early endosome|plasma membrane|response to auditory stimulus|integral component of membrane|negative regulation of axon extension|clathrin-coated vesicle membrane|cytoplasmic vesicle|early endosome membrane|multicellular organismal response to stress|intracellular membrane-bounded organelle|negative regulation of axon extension involved in regeneration|positive regulation of SMAD protein signal transduction|membrane organization|negative regulation of dendrite development KIAA0319L 1874.499457 1787.33746 1961.661453 1.097532781 0.134264031 0.679282603 1 11.36358737 13.00914894 79932 KIAA0319 like "GO:0000139,GO:0005515,GO:0005730,GO:0005794,GO:0005886,GO:0016021,GO:0016032,GO:0031410" Golgi membrane|protein binding|nucleolus|Golgi apparatus|plasma membrane|integral component of membrane|viral process|cytoplasmic vesicle KIAA0513 66.55928801 71.04691779 62.07165824 0.873671373 -0.194837375 0.817338422 1 0.342529819 0.31214934 9764 KIAA0513 GO:0005737 cytoplasm KIAA0586 519.5322547 559.2407386 479.8237709 0.857991448 -0.220964828 0.586997607 1 3.196069795 2.860323429 9786 KIAA0586 "GO:0001917,GO:0005737,GO:0005813,GO:0005814,GO:0007224,GO:0036064,GO:0060271,GO:0070201" photoreceptor inner segment|cytoplasm|centrosome|centriole|smoothened signaling pathway|ciliary basal body|cilium assembly|regulation of establishment of protein localization KIAA0753 669.3760775 632.3175683 706.4345867 1.117214865 0.159906674 0.677196093 1 4.968143679 5.789576307 9851 KIAA0753 "GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0034451,GO:0071539" protein binding|centrosome|centriole|cytosol|centriole replication|centriolar satellite|protein localization to centrosome KIAA0754 1978.000717 1925.371472 2030.629963 1.054669186 0.076790545 0.812996257 1 13.15968593 14.47697124 643314 KIAA0754 KIAA0825 32.52584992 34.50850292 30.54319691 0.885091914 -0.176100812 0.885194002 1 0.0637766 0.05887971 285600 KIAA0825 GO:0005515 protein binding KIAA0895 261.3283974 251.7090802 270.9477146 1.076432024 0.106257217 0.836432474 1 2.466275282 2.769134749 23366 KIAA0895 KIAA0895L 231.1172507 207.0510175 255.1834839 1.232466698 0.301548664 0.560827643 1 2.974022577 3.823273653 653319 KIAA0895 like GO:0005515 protein binding KIAA0930 1493.856826 1630.019285 1357.694366 0.832931474 -0.263730286 0.426826386 1 12.14575937 10.55236672 23313 KIAA0930 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process KIAA1109 3569.488287 2820.562636 4318.413938 1.531046991 0.614518563 0.054053943 1 7.93223095 12.66775923 84162 KIAA1109 "GO:0001558,GO:0005515,GO:0005634,GO:0006909,GO:0016020,GO:0016021,GO:0016197,GO:0030856,GO:0032456,GO:0048488,GO:0098793" regulation of cell growth|protein binding|nucleus|phagocytosis|membrane|integral component of membrane|endosomal transport|regulation of epithelial cell differentiation|endocytic recycling|synaptic vesicle endocytosis|presynapse KIAA1143 1291.051946 1135.735729 1446.368163 1.273507672 0.348807651 0.302696708 1 11.20393612 14.88291903 57456 KIAA1143 GO:0005515 protein binding KIAA1191 3088.819791 2560.733908 3616.905673 1.412448854 0.498198627 0.117777367 1 46.23605659 68.11918555 57179 KIAA1191 "GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0008150,GO:0016491,GO:0055114" molecular_function|protein binding|cellular_component|cytoplasm|biological_process|oxidoreductase activity|oxidation-reduction process KIAA1217 701.0690801 811.9647747 590.1733855 0.726846045 -0.460278278 0.222963527 1 3.612998717 2.739215301 56243 KIAA1217 "GO:0003674,GO:0005737,GO:0030234,GO:0048706,GO:0050790" molecular_function|cytoplasm|enzyme regulator activity|embryonic skeletal system development|regulation of catalytic activity KIAA1328 204.8147486 193.85659 215.7729072 1.11305428 0.15452395 0.779585115 1 0.910943811 1.057605896 57536 KIAA1328 GO:0005515 protein binding KIAA1522 2106.866474 2046.151232 2167.581716 1.059345801 0.083173604 0.79673145 1 17.46676918 19.3003978 57648 KIAA1522 GO:0030154 cell differentiation KIAA1549 1110.06689 1257.530445 962.603335 0.765471197 -0.385580001 0.265620732 1 5.094343363 4.067550907 57670 KIAA1549 "GO:0005886,GO:0016021,GO:0032391" plasma membrane|integral component of membrane|photoreceptor connecting cilium KIAA1549L 2181.631763 2173.020728 2190.242798 1.007925405 0.011388871 0.973227491 1 11.23821443 11.8152152 25758 KIAA1549 like GO:0016021 integral component of membrane KIAA1586 183.6194395 159.348087 207.8907919 1.30463312 0.383644159 0.491580315 1 2.835705714 3.858917443 57691 KIAA1586 "GO:0016925,GO:0061665" protein sumoylation|SUMO ligase activity KIAA1614 167.2937909 87.28621328 247.3013686 2.833223705 1.502444518 0.009715321 0.415398921 0.444474037 1.313539673 57710 KIAA1614 "GO:0005080,GO:0005634,GO:0005938,GO:0007098,GO:0007163,GO:0016324,GO:0060341" protein kinase C binding|nucleus|cell cortex|centrosome cycle|establishment or maintenance of cell polarity|apical plasma membrane|regulation of cellular localization KIAA1671 660.7732001 684.0803227 637.4660775 0.931858521 -0.10181716 0.793125783 1 2.687422824 2.612172853 85379 KIAA1671 KIAA1755 9.030683284 11.16451565 6.896850916 0.617747436 -0.694910978 0.677685443 1 0.056965881 0.036706392 85449 KIAA1755 KIAA1841 265.1506888 243.5894324 286.7119452 1.177029489 0.235150466 0.636458114 1 2.228092003 2.735497948 84542 KIAA1841 KIAA1958 535.2222565 554.1659587 516.2785543 0.931631664 -0.102168421 0.802945016 1 1.091446659 1.060627019 158405 KIAA1958 GO:0005515 protein binding KIAA2013 1707.0436 1857.369422 1556.717778 0.838130401 -0.254753371 0.435768786 1 33.3697087 29.17292255 90231 KIAA2013 "GO:0005515,GO:0016020,GO:0016021" protein binding|membrane|integral component of membrane KIAA2026 641.0166935 579.5398579 702.493529 1.212157403 0.27757705 0.471958869 1 1.735756908 2.194642828 158358 KIAA2026 KICS2 197.6600763 243.5894324 151.7307201 0.622895331 -0.682938336 0.207322404 1 2.244713504 1.458451276 144577 KICSTOR subunit 2 KIDINS220 1293.849633 1428.043048 1159.656218 0.812059707 -0.300342289 0.374734706 1 5.700294966 4.828377537 57498 kinase D interacting substrate 220 "GO:0000186,GO:0001701,GO:0005770,GO:0005829,GO:0010976,GO:0016020,GO:0016021,GO:0019887,GO:0030165,GO:0032991,GO:0038180,GO:0048813,GO:1990090" activation of MAPKK activity|in utero embryonic development|late endosome|cytosol|positive regulation of neuron projection development|membrane|integral component of membrane|protein kinase regulator activity|PDZ domain binding|protein-containing complex|nerve growth factor signaling pathway|dendrite morphogenesis|cellular response to nerve growth factor stimulus hsa04722 Neurotrophin signaling pathway KIF11 5741.230787 5260.516784 6221.94479 1.182763034 0.242161059 0.454221205 1 53.11535429 65.52903236 3832 kinesin family member 11 "GO:0000278,GO:0000922,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0005876,GO:0006890,GO:0007018,GO:0007051,GO:0007052,GO:0007100,GO:0008017,GO:0008574,GO:0016020,GO:0019886,GO:0019901,GO:0032991,GO:0046602,GO:0051301,GO:0072686,GO:0090307" "mitotic cell cycle|spindle pole|microtubule motor activity|protein binding|ATP binding|nucleus|spindle|cytosol|kinesin complex|microtubule|spindle microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|spindle organization|mitotic spindle organization|mitotic centrosome separation|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|protein-containing complex|regulation of mitotic centrosome separation|cell division|mitotic spindle|mitotic spindle assembly" KIF12 24.42104795 19.2841634 29.5579325 1.532756796 0.616128801 0.573062254 1 0.367170995 0.587026282 113220 kinesin family member 12 "GO:0003674,GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0008150,GO:0016887,GO:0070062" molecular_function|microtubule motor activity|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|biological_process|ATPase activity|extracellular exosome KIF13A 691.0640188 666.8260712 715.3019664 1.072696461 0.101241896 0.79216583 1 3.687747116 4.126234533 63971 kinesin family member 13A "GO:0003777,GO:0005515,GO:0005524,GO:0005813,GO:0005871,GO:0005874,GO:0006886,GO:0007018,GO:0007049,GO:0008017,GO:0008333,GO:0010008,GO:0016887,GO:0030496,GO:0032438,GO:0032465,GO:0032588,GO:0035459,GO:0043001,GO:0051301,GO:0072383" microtubule motor activity|protein binding|ATP binding|centrosome|kinesin complex|microtubule|intracellular protein transport|microtubule-based movement|cell cycle|microtubule binding|endosome to lysosome transport|endosome membrane|ATPase activity|midbody|melanosome organization|regulation of cytokinesis|trans-Golgi network membrane|vesicle cargo loading|Golgi to plasma membrane protein transport|cell division|plus-end-directed vesicle transport along microtubule KIF13B 716.7726899 639.4222601 794.1231197 1.241938496 0.312593729 0.40605343 1 3.583939987 4.642765488 23303 kinesin family member 13B "GO:0003777,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005871,GO:0005874,GO:0005902,GO:0006605,GO:0007018,GO:0007165,GO:0008017,GO:0016887,GO:0019901,GO:0030424,GO:0033270,GO:0042110,GO:0050770,GO:0071889" microtubule motor activity|protein binding|ATP binding|cytoplasm|cytosol|kinesin complex|microtubule|microvillus|protein targeting|microtubule-based movement|signal transduction|microtubule binding|ATPase activity|protein kinase binding|axon|paranode region of axon|T cell activation|regulation of axonogenesis|14-3-3 protein binding KIF14 1984.669684 1606.675298 2362.664071 1.470529904 0.556336122 0.084918196 1 10.23295219 15.69606307 9928 kinesin family member 14 "GO:0001558,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005871,GO:0005874,GO:0005886,GO:0007018,GO:0007019,GO:0007080,GO:0008017,GO:0008284,GO:0008574,GO:0010389,GO:0015631,GO:0016020,GO:0016887,GO:0019901,GO:0021685,GO:0021693,GO:0021695,GO:0021766,GO:0021772,GO:0021846,GO:0021987,GO:0030155,GO:0030165,GO:0030334,GO:0030496,GO:0031146,GO:0031641,GO:0032147,GO:0032467,GO:0032487,GO:0033624,GO:0034446,GO:0043066,GO:0043161,GO:0043523,GO:0043524,GO:0045184,GO:0051233,GO:0051301,GO:0090543,GO:1903429,GO:2000045" "regulation of cell growth|microtubule motor activity|protein binding|ATP binding|nucleus|cytosol|kinesin complex|microtubule|plasma membrane|microtubule-based movement|microtubule depolymerization|mitotic metaphase plate congression|microtubule binding|positive regulation of cell population proliferation|ATP-dependent microtubule motor activity, plus-end-directed|regulation of G2/M transition of mitotic cell cycle|tubulin binding|membrane|ATPase activity|protein kinase binding|cerebellar granular layer structural organization|cerebellar Purkinje cell layer structural organization|cerebellar cortex development|hippocampus development|olfactory bulb development|cell proliferation in forebrain|cerebral cortex development|regulation of cell adhesion|PDZ domain binding|regulation of cell migration|midbody|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of myelination|activation of protein kinase activity|positive regulation of cytokinesis|regulation of Rap protein signal transduction|negative regulation of integrin activation|substrate adhesion-dependent cell spreading|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|establishment of protein localization|spindle midzone|cell division|Flemming body|regulation of cell maturation|regulation of G1/S transition of mitotic cell cycle" KIF15 1039.612565 987.5521572 1091.672974 1.105433233 0.14461189 0.681008467 1 9.403277475 10.84245674 56992 kinesin family member 15 "GO:0000278,GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005813,GO:0005819,GO:0005829,GO:0005871,GO:0005873,GO:0005874,GO:0006890,GO:0007018,GO:0008017,GO:0016020,GO:0016887,GO:0019886" "mitotic cell cycle|motor activity|microtubule motor activity|protein binding|ATP binding|centrosome|spindle|cytosol|kinesin complex|plus-end kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule binding|membrane|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II" KIF16B 724.9814123 661.7512914 788.2115332 1.19109935 0.252293754 0.501928605 1 4.283114171 5.321371369 55614 kinesin family member 16B "GO:0001704,GO:0001919,GO:0003777,GO:0005524,GO:0005547,GO:0005737,GO:0005768,GO:0005769,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0006895,GO:0007018,GO:0007173,GO:0007492,GO:0008017,GO:0008543,GO:0008574,GO:0016887,GO:0031901,GO:0032266,GO:0032801,GO:0043325,GO:0045022,GO:0080025" "formation of primary germ layer|regulation of receptor recycling|microtubule motor activity|ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|endosome|early endosome|spindle|cytosol|kinesin complex|microtubule|Golgi to endosome transport|microtubule-based movement|epidermal growth factor receptor signaling pathway|endoderm development|microtubule binding|fibroblast growth factor receptor signaling pathway|ATP-dependent microtubule motor activity, plus-end-directed|ATPase activity|early endosome membrane|phosphatidylinositol-3-phosphate binding|receptor catabolic process|phosphatidylinositol-3,4-bisphosphate binding|early endosome to late endosome transport|phosphatidylinositol-3,5-bisphosphate binding" KIF17 28.42148872 23.34398727 33.49899016 1.435015782 0.521066604 0.62040842 1 0.28921003 0.432898377 57576 kinesin family member 17 "GO:0003777,GO:0005524,GO:0005815,GO:0005829,GO:0005871,GO:0005874,GO:0005929,GO:0005930,GO:0007018,GO:0008017,GO:0008574,GO:0016192,GO:0016887,GO:0030030,GO:0032391,GO:0032839,GO:0035735,GO:0036064,GO:0043005,GO:0098971,GO:1990075" "microtubule motor activity|ATP binding|microtubule organizing center|cytosol|kinesin complex|microtubule|cilium|axoneme|microtubule-based movement|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|vesicle-mediated transport|ATPase activity|cell projection organization|photoreceptor connecting cilium|dendrite cytoplasm|intraciliary transport involved in cilium assembly|ciliary basal body|neuron projection|anterograde dendritic transport of neurotransmitter receptor complex|periciliary membrane compartment" KIF18A 873.2555422 762.2319322 984.2791521 1.291311884 0.368837489 0.307339026 1 9.262082144 12.47543523 81930 kinesin family member 18A "GO:0000070,GO:0000776,GO:0001726,GO:0003777,GO:0003779,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005828,GO:0005829,GO:0005871,GO:0005874,GO:0005901,GO:0006890,GO:0007018,GO:0007019,GO:0007080,GO:0007140,GO:0008017,GO:0008574,GO:0015031,GO:0015630,GO:0016887,GO:0019886,GO:0051010,GO:0061673,GO:0070463,GO:0070507,GO:0071392,GO:0072520,GO:1990023" "mitotic sister chromatid segregation|kinetochore|ruffle|microtubule motor activity|actin binding|protein binding|ATP binding|nucleus|cytoplasm|microtubule organizing center|kinetochore microtubule|cytosol|kinesin complex|microtubule|caveola|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule depolymerization|mitotic metaphase plate congression|male meiotic nuclear division|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|protein transport|microtubule cytoskeleton|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule plus-end binding|mitotic spindle astral microtubule|tubulin-dependent ATPase activity|regulation of microtubule cytoskeleton organization|cellular response to estradiol stimulus|seminiferous tubule development|mitotic spindle midzone" KIF18B 1519.195836 1375.265337 1663.126335 1.209313061 0.274187771 0.407727733 1 13.85564704 17.4775875 146909 kinesin family member 18B "GO:0000070,GO:0000235,GO:0000278,GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005871,GO:0005874,GO:0007018,GO:0007019,GO:0008017,GO:0008574,GO:0016604,GO:0016887,GO:0019894,GO:0035371,GO:0051301,GO:0051302,GO:0061673,GO:1990023,GO:1990752" "mitotic sister chromatid segregation|astral microtubule|mitotic cell cycle|motor activity|microtubule motor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|kinesin complex|microtubule|microtubule-based movement|microtubule depolymerization|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|nuclear body|ATPase activity|kinesin binding|microtubule plus-end|cell division|regulation of cell division|mitotic spindle astral microtubule|mitotic spindle midzone|microtubule end" KIF1B 3307.001427 3230.604847 3383.398006 1.047295527 0.066668601 0.834702771 1 9.82872221 10.73698235 23095 kinesin family member 1B "GO:0003777,GO:0005515,GO:0005524,GO:0005739,GO:0005871,GO:0005874,GO:0005875,GO:0006915,GO:0007018,GO:0007270,GO:0007274,GO:0008017,GO:0008021,GO:0008089,GO:0008574,GO:0010628,GO:0016192,GO:0016887,GO:0019894,GO:0019900,GO:0030424,GO:0030425,GO:0030659,GO:0030705,GO:0031410,GO:0032418,GO:0043005,GO:0097110,GO:1904115,GO:1904647,GO:1990048,GO:1990049,GO:1990090,GO:1990778" "microtubule motor activity|protein binding|ATP binding|mitochondrion|kinesin complex|microtubule|microtubule associated complex|apoptotic process|microtubule-based movement|neuron-neuron synaptic transmission|neuromuscular synaptic transmission|microtubule binding|synaptic vesicle|anterograde axonal transport|ATP-dependent microtubule motor activity, plus-end-directed|positive regulation of gene expression|vesicle-mediated transport|ATPase activity|kinesin binding|kinase binding|axon|dendrite|cytoplasmic vesicle membrane|cytoskeleton-dependent intracellular transport|cytoplasmic vesicle|lysosome localization|neuron projection|scaffold protein binding|axon cytoplasm|response to rotenone|anterograde neuronal dense core vesicle transport|retrograde neuronal dense core vesicle transport|cellular response to nerve growth factor stimulus|protein localization to cell periphery" KIF1C 6011.381035 4970.239377 7052.522694 1.418950308 0.504824066 0.12028126 1 48.35287947 71.56578809 10749 kinesin family member 1C "GO:0003723,GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005783,GO:0005794,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0008017,GO:0008574,GO:0016192,GO:0016887,GO:0030424,GO:0030425,GO:0030705,GO:1904115,GO:1990048,GO:1990049" "RNA binding|motor activity|microtubule motor activity|protein binding|ATP binding|endoplasmic reticulum|Golgi apparatus|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|vesicle-mediated transport|ATPase activity|axon|dendrite|cytoskeleton-dependent intracellular transport|axon cytoplasm|anterograde neuronal dense core vesicle transport|retrograde neuronal dense core vesicle transport" KIF20A 2191.555915 2211.589055 2171.522774 0.981883487 -0.026376254 0.935857122 1 36.19036628 37.0654148 10112 kinesin family member 20A "GO:0000281,GO:0001578,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0005819,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0015031,GO:0016887,GO:0019901,GO:0030496,GO:0032154,GO:0032465,GO:0045171,GO:0061952" mitotic cytokinesis|microtubule bundle formation|microtubule motor activity|protein binding|ATP binding|nucleus|nucleoplasm|Golgi apparatus|spindle|kinesin complex|microtubule|microtubule-based movement|microtubule binding|protein transport|ATPase activity|protein kinase binding|midbody|cleavage furrow|regulation of cytokinesis|intercellular bridge|midbody abscission KIF20B 3025.040622 2814.4729 3235.608344 1.149632083 0.201172229 0.527375788 1 22.13058897 26.53797479 9585 kinesin family member 20B "GO:0001843,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005871,GO:0005874,GO:0007018,GO:0007050,GO:0007088,GO:0008017,GO:0008284,GO:0008574,GO:0016887,GO:0030426,GO:0030496,GO:0032467,GO:0035372,GO:0042803,GO:0045171,GO:0048471,GO:0048812,GO:0050699,GO:0051233,GO:0051301,GO:0070938,GO:0090316,GO:0097431,GO:1903438,GO:1990023,GO:2000114,GO:2001224" "neural tube closure|microtubule motor activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|kinesin complex|microtubule|microtubule-based movement|cell cycle arrest|regulation of mitotic nuclear division|microtubule binding|positive regulation of cell population proliferation|ATP-dependent microtubule motor activity, plus-end-directed|ATPase activity|growth cone|midbody|positive regulation of cytokinesis|protein localization to microtubule|protein homodimerization activity|intercellular bridge|perinuclear region of cytoplasm|neuron projection morphogenesis|WW domain binding|spindle midzone|cell division|contractile ring|positive regulation of intracellular protein transport|mitotic spindle pole|positive regulation of mitotic cytokinetic process|mitotic spindle midzone|regulation of establishment of cell polarity|positive regulation of neuron migration" KIF21A 825.6132325 839.3685858 811.8578792 0.967224522 -0.048077273 0.898427844 1 6.669447405 6.728729667 55605 kinesin family member 21A "GO:0003777,GO:0005515,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0005886,GO:0007018,GO:0008017,GO:0016887" microtubule motor activity|protein binding|ATP binding|cytosol|kinesin complex|microtubule|plasma membrane|microtubule-based movement|microtubule binding|ATPase activity KIF21B 2609.200893 2978.895767 2239.506019 0.751790661 -0.4115971 0.196874587 1 15.29506911 11.99400706 23046 kinesin family member 21B "GO:0003777,GO:0005524,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0030425,GO:0030426,GO:0031410" microtubule motor activity|ATP binding|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|dendrite|growth cone|cytoplasmic vesicle KIF22 1373.405156 1208.812558 1537.997754 1.272321125 0.347462843 0.300332119 1 25.48796488 33.82578062 3835 kinesin family member 22 "GO:0000278,GO:0000776,GO:0000785,GO:0003677,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005871,GO:0005874,GO:0006281,GO:0006890,GO:0007018,GO:0007062,GO:0007080,GO:0008017,GO:0016607,GO:0016887,GO:0019886,GO:0051310,GO:0072686" "mitotic cell cycle|kinetochore|chromatin|DNA binding|microtubule motor activity|protein binding|ATP binding|nucleus|cytosol|kinesin complex|microtubule|DNA repair|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|sister chromatid cohesion|mitotic metaphase plate congression|microtubule binding|nuclear speck|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|metaphase plate congression|mitotic spindle" hsa04914 Progesterone-mediated oocyte maturation KIF23 2371.026702 1986.26883 2755.784573 1.387417721 0.472402217 0.139613722 1 26.7120311 38.6571719 9493 kinesin family member 23 "GO:0000022,GO:0000281,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0005925,GO:0006890,GO:0007018,GO:0008017,GO:0016887,GO:0019886,GO:0030496,GO:0032467,GO:0051256,GO:0072686,GO:0090543,GO:0097149" "mitotic spindle elongation|mitotic cytokinesis|microtubule motor activity|protein binding|ATP binding|nucleus|nucleoplasm|centrosome|spindle|cytosol|kinesin complex|microtubule|focal adhesion|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule binding|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|positive regulation of cytokinesis|mitotic spindle midzone assembly|mitotic spindle|Flemming body|centralspindlin complex" hsa05206 MicroRNAs in cancer KIF24 801.8144694 694.2298824 909.3990565 1.309939372 0.389500042 0.289025291 1 3.794549368 5.184744183 347240 kinesin family member 24 "GO:0003777,GO:0005515,GO:0005524,GO:0005814,GO:0005829,GO:0005874,GO:0007018,GO:0007019,GO:0008017,GO:0032991,GO:0042802,GO:0060271,GO:0097711" microtubule motor activity|protein binding|ATP binding|centriole|cytosol|microtubule|microtubule-based movement|microtubule depolymerization|microtubule binding|protein-containing complex|identical protein binding|cilium assembly|ciliary basal body-plasma membrane docking KIF26B 6.567522243 11.16451565 1.970528833 0.176499267 -2.5022659 0.161860904 1 0.041598126 0.007658304 55083 kinesin family member 26B "GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0022409,GO:0030010,GO:0072092" microtubule motor activity|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|positive regulation of cell-cell adhesion|establishment of cell polarity|ureteric bud invasion KIF27 130.9550521 128.899408 133.0106962 1.031895323 0.045296629 0.954976953 1 0.655649321 0.705704992 55582 kinesin family member 27 "GO:0003351,GO:0003777,GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005871,GO:0005874,GO:0005929,GO:0007018,GO:0008017,GO:0016887,GO:0021591,GO:0060271" epithelial cilium movement involved in extracellular fluid movement|microtubule motor activity|protein binding|ATP binding|extracellular region|cytoplasm|kinesin complex|microtubule|cilium|microtubule-based movement|microtubule binding|ATPase activity|ventricular system development|cilium assembly KIF2A 2501.170433 2362.817494 2639.523372 1.117108443 0.159769242 0.616987265 1 14.76658077 17.20644732 3796 kinesin family member 2A "GO:0000226,GO:0000922,GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0005876,GO:0006890,GO:0007018,GO:0007019,GO:0007052,GO:0007399,GO:0008017,GO:0016020,GO:0016604,GO:0016887,GO:0019886,GO:0030154,GO:0030334,GO:0051301,GO:0090307,GO:0120103" "microtubule cytoskeleton organization|spindle pole|motor activity|microtubule motor activity|protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|centrosome|centriole|spindle|cytosol|kinesin complex|microtubule|spindle microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule depolymerization|mitotic spindle organization|nervous system development|microtubule binding|membrane|nuclear body|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|cell differentiation|regulation of cell migration|cell division|mitotic spindle assembly|centriolar subdistal appendage" KIF2C 2923.141468 2617.571442 3228.711493 1.233475977 0.302729619 0.341578102 1 38.12791467 49.05572274 11004 kinesin family member 2C "GO:0000775,GO:0000776,GO:0000777,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005813,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0005881,GO:0006890,GO:0007018,GO:0007019,GO:0007080,GO:0008017,GO:0015630,GO:0016020,GO:0016887,GO:0019237,GO:0019886,GO:0030951,GO:0035371,GO:0051010,GO:0051301,GO:0051310,GO:0051315,GO:0051983" "chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|microtubule motor activity|protein binding|ATP binding|nucleus|centrosome|spindle|cytosol|kinesin complex|microtubule|cytoplasmic microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule depolymerization|mitotic metaphase plate congression|microtubule binding|microtubule cytoskeleton|membrane|ATPase activity|centromeric DNA binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|establishment or maintenance of microtubule cytoskeleton polarity|microtubule plus-end|microtubule plus-end binding|cell division|metaphase plate congression|attachment of mitotic spindle microtubules to kinetochore|regulation of chromosome segregation" KIF3A 777.7645659 700.3196182 855.2095136 1.221170293 0.2882644 0.435875235 1 4.901702333 6.243657836 11127 kinesin family member 3A "GO:0003777,GO:0005515,GO:0005524,GO:0005813,GO:0005814,GO:0005829,GO:0005871,GO:0005874,GO:0005876,GO:0005929,GO:0006890,GO:0006996,GO:0007018,GO:0008017,GO:0008089,GO:0008574,GO:0010457,GO:0015031,GO:0015630,GO:0016887,GO:0016939,GO:0019886,GO:0019903,GO:0030507,GO:0031267,GO:0034454,GO:0035735,GO:0060271,GO:0070062,GO:0072383,GO:0097542,GO:1902414,GO:1904115" "microtubule motor activity|protein binding|ATP binding|centrosome|centriole|cytosol|kinesin complex|microtubule|spindle microtubule|cilium|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|organelle organization|microtubule-based movement|microtubule binding|anterograde axonal transport|ATP-dependent microtubule motor activity, plus-end-directed|centriole-centriole cohesion|protein transport|microtubule cytoskeleton|ATPase activity|kinesin II complex|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein phosphatase binding|spectrin binding|small GTPase binding|microtubule anchoring at centrosome|intraciliary transport involved in cilium assembly|cilium assembly|extracellular exosome|plus-end-directed vesicle transport along microtubule|ciliary tip|protein localization to cell junction|axon cytoplasm" hsa04340 Hedgehog signaling pathway KIF3B 3018.97588 3780.710982 2257.240778 0.597041347 -0.744097248 0.019834415 0.608225464 31.30799112 19.49734787 9371 kinesin family member 3B "GO:0003777,GO:0005515,GO:0005524,GO:0005813,GO:0005829,GO:0005871,GO:0005873,GO:0005874,GO:0005876,GO:0005929,GO:0006890,GO:0007018,GO:0007052,GO:0007100,GO:0007368,GO:0008017,GO:0008089,GO:0008574,GO:0015630,GO:0016020,GO:0016887,GO:0016939,GO:0019886,GO:0030496,GO:0031267,GO:0032467,GO:0035735,GO:0070062,GO:0072383,GO:0090307,GO:0097542,GO:0120170,GO:1904115" "microtubule motor activity|protein binding|ATP binding|centrosome|cytosol|kinesin complex|plus-end kinesin complex|microtubule|spindle microtubule|cilium|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|mitotic spindle organization|mitotic centrosome separation|determination of left/right symmetry|microtubule binding|anterograde axonal transport|ATP-dependent microtubule motor activity, plus-end-directed|microtubule cytoskeleton|membrane|ATPase activity|kinesin II complex|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|small GTPase binding|positive regulation of cytokinesis|intraciliary transport involved in cilium assembly|extracellular exosome|plus-end-directed vesicle transport along microtubule|mitotic spindle assembly|ciliary tip|intraciliary transport particle B binding|axon cytoplasm" KIF3C 1371.391574 1003.791453 1738.991695 1.732423294 0.792791476 0.018583358 0.589604582 9.51675326 17.19724007 3797 kinesin family member 3C "GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0005929,GO:0006890,GO:0007018,GO:0008017,GO:0016887,GO:0019886,GO:0035735,GO:0072384,GO:0097542" "motor activity|microtubule motor activity|protein binding|ATP binding|cytosol|kinesin complex|microtubule|cilium|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule binding|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|intraciliary transport involved in cilium assembly|organelle transport along microtubule|ciliary tip" KIF4A 2039.635167 1794.442152 2284.828182 1.27328049 0.348550264 0.27893159 1 20.71152338 27.50755928 24137 kinesin family member 4A "GO:0000281,GO:0003677,GO:0003777,GO:0005515,GO:0005524,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0005876,GO:0006890,GO:0006996,GO:0007018,GO:0007052,GO:0008017,GO:0008089,GO:0016020,GO:0016363,GO:0019886,GO:0030496,GO:0046872,GO:0051256,GO:0051536,GO:1904115" "mitotic cytokinesis|DNA binding|microtubule motor activity|protein binding|ATP binding|nucleoplasm|chromosome|cytoplasm|cytosol|spindle microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|organelle organization|microtubule-based movement|mitotic spindle organization|microtubule binding|anterograde axonal transport|membrane|nuclear matrix|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|metal ion binding|mitotic spindle midzone assembly|iron-sulfur cluster binding|axon cytoplasm" KIF4B 23.0173802 24.35894324 21.67581716 0.889850473 -0.168365163 0.915323575 1 0.281215989 0.261019513 285643 kinesin family member 4B "GO:0000281,GO:0003677,GO:0003777,GO:0005524,GO:0005654,GO:0005829,GO:0005874,GO:0006890,GO:0007018,GO:0007052,GO:0008017,GO:0016363,GO:0019886,GO:0046872,GO:0051256,GO:0051536" "mitotic cytokinesis|DNA binding|microtubule motor activity|ATP binding|nucleoplasm|cytosol|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|mitotic spindle organization|microtubule binding|nuclear matrix|antigen processing and presentation of exogenous peptide antigen via MHC class II|metal ion binding|mitotic spindle midzone assembly|iron-sulfur cluster binding" KIF5A 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.008894954 0.027020071 3798 kinesin family member 5A "GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0007268,GO:0007411,GO:0008017,GO:0008574,GO:0016020,GO:0016192,GO:0016887,GO:0019886,GO:0030705,GO:0032839,GO:0043204,GO:0045202,GO:0048471,GO:0048489,GO:0098971,GO:0099641,GO:1904115,GO:1990049" "motor activity|microtubule motor activity|protein binding|ATP binding|cytosol|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|chemical synaptic transmission|axon guidance|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|membrane|vesicle-mediated transport|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|cytoskeleton-dependent intracellular transport|dendrite cytoplasm|perikaryon|synapse|perinuclear region of cytoplasm|synaptic vesicle transport|anterograde dendritic transport of neurotransmitter receptor complex|anterograde axonal protein transport|axon cytoplasm|retrograde neuronal dense core vesicle transport" "hsa04144,hsa04728,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132,hsa05223" Endocytosis|Dopaminergic synapse|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Non-small cell lung cancer KIF5B 6038.047263 6018.688892 6057.405633 1.006432753 0.009250779 0.977812898 1 50.23489778 52.73588208 3799 kinesin family member 5B "GO:0003777,GO:0005515,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0007018,GO:0007028,GO:0007411,GO:0008017,GO:0008432,GO:0008574,GO:0016020,GO:0016887,GO:0021766,GO:0030705,GO:0031340,GO:0031982,GO:0032230,GO:0032839,GO:0034451,GO:0035253,GO:0035617,GO:0035774,GO:0042391,GO:0042802,GO:0043268,GO:0044295,GO:0045296,GO:0045335,GO:0047496,GO:0048471,GO:0048489,GO:0051642,GO:0071346,GO:0072383,GO:0090316,GO:0098971,GO:0099609,GO:0099641,GO:1903078,GO:1904115,GO:1905152,GO:1990048,GO:1990049" "microtubule motor activity|protein binding|ATP binding|cytosol|kinesin complex|microtubule|microtubule-based movement|cytoplasm organization|axon guidance|microtubule binding|JUN kinase binding|ATP-dependent microtubule motor activity, plus-end-directed|membrane|ATPase activity|hippocampus development|cytoskeleton-dependent intracellular transport|positive regulation of vesicle fusion|vesicle|positive regulation of synaptic transmission, GABAergic|dendrite cytoplasm|centriolar satellite|ciliary rootlet|stress granule disassembly|positive regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of membrane potential|identical protein binding|positive regulation of potassium ion transport|axonal growth cone|cadherin binding|phagocytic vesicle|vesicle transport along microtubule|perinuclear region of cytoplasm|synaptic vesicle transport|centrosome localization|cellular response to interferon-gamma|plus-end-directed vesicle transport along microtubule|positive regulation of intracellular protein transport|anterograde dendritic transport of neurotransmitter receptor complex|microtubule lateral binding|anterograde axonal protein transport|positive regulation of protein localization to plasma membrane|axon cytoplasm|positive regulation of voltage-gated sodium channel activity|anterograde neuronal dense core vesicle transport|retrograde neuronal dense core vesicle transport" "hsa04144,hsa04728,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132,hsa05223" Endocytosis|Dopaminergic synapse|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Non-small cell lung cancer KIF5C 1223.591025 1137.765641 1309.41641 1.150866543 0.202720545 0.552969701 1 7.689326915 9.230584877 3800 kinesin family member 5C "GO:0003777,GO:0005515,GO:0005524,GO:0005871,GO:0005874,GO:0006996,GO:0007018,GO:0007411,GO:0008017,GO:0008045,GO:0008574,GO:0016887,GO:0030705,GO:0032839,GO:0035253,GO:0043025,GO:0044295,GO:0048489,GO:0051028,GO:0098971,GO:0099641,GO:0150034,GO:1904115" "microtubule motor activity|protein binding|ATP binding|kinesin complex|microtubule|organelle organization|microtubule-based movement|axon guidance|microtubule binding|motor neuron axon guidance|ATP-dependent microtubule motor activity, plus-end-directed|ATPase activity|cytoskeleton-dependent intracellular transport|dendrite cytoplasm|ciliary rootlet|neuronal cell body|axonal growth cone|synaptic vesicle transport|mRNA transport|anterograde dendritic transport of neurotransmitter receptor complex|anterograde axonal protein transport|distal axon|axon cytoplasm" "hsa04144,hsa04728,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132,hsa05223" Endocytosis|Dopaminergic synapse|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Non-small cell lung cancer KIF6 8.060264643 12.17947162 3.941057666 0.32358199 -1.627796782 0.302513 1 0.049878489 0.016835017 221458 kinesin family member 6 "GO:0001673,GO:0003777,GO:0005515,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887" male germ cell nucleus|microtubule motor activity|protein binding|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity KIF7 1287.226933 1177.348923 1397.104943 1.186653264 0.246898446 0.46615621 1 12.6064629 15.60389495 374654 kinesin family member 7 "GO:0003777,GO:0005515,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0005929,GO:0007018,GO:0008017,GO:0016887,GO:0036064,GO:0045879,GO:0045880,GO:0097542" microtubule motor activity|protein binding|ATP binding|cytoplasm|kinesin complex|microtubule|cilium|microtubule-based movement|microtubule binding|ATPase activity|ciliary basal body|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|ciliary tip "hsa04340,hsa05200,hsa05217" Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma KIF9 71.55983898 76.12169763 66.99798033 0.880143013 -0.18419013 0.823047416 1 0.944693811 0.867281826 64147 kinesin family member 9 "GO:0002102,GO:0003777,GO:0005515,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0022617,GO:0031982,GO:0042802,GO:0071801,GO:1903008" podosome|microtubule motor activity|protein binding|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|extracellular matrix disassembly|vesicle|identical protein binding|regulation of podosome assembly|organelle disassembly KIFAP3 552.5589017 493.2686006 611.8492027 1.240397629 0.310802673 0.436487544 1 5.193828373 6.719925398 22920 kinesin associated protein 3 "GO:0000794,GO:0005515,GO:0005783,GO:0005794,GO:0005813,GO:0005829,GO:0005876,GO:0005929,GO:0005930,GO:0006890,GO:0007017,GO:0007018,GO:0007165,GO:0008285,GO:0015630,GO:0016939,GO:0019886,GO:0019894,GO:0019903,GO:0032391,GO:0035735,GO:0035869,GO:0036064,GO:0043066,GO:0044782,GO:0046587,GO:0065003,GO:0072383,GO:0097542,GO:0120170,GO:1990075" "condensed nuclear chromosome|protein binding|endoplasmic reticulum|Golgi apparatus|centrosome|cytosol|spindle microtubule|cilium|axoneme|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based process|microtubule-based movement|signal transduction|negative regulation of cell population proliferation|microtubule cytoskeleton|kinesin II complex|antigen processing and presentation of exogenous peptide antigen via MHC class II|kinesin binding|protein phosphatase binding|photoreceptor connecting cilium|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|negative regulation of apoptotic process|cilium organization|positive regulation of calcium-dependent cell-cell adhesion|protein-containing complex assembly|plus-end-directed vesicle transport along microtubule|ciliary tip|intraciliary transport particle B binding|periciliary membrane compartment" KIFBP 2216.574999 2036.001673 2397.148325 1.177380332 0.235580433 0.46228579 1 26.52850582 32.57958112 26128 kinesin family binding protein "GO:0005515,GO:0005739,GO:0005856,GO:0006839,GO:0007399,GO:0019894,GO:0030154" protein binding|mitochondrion|cytoskeleton|mitochondrial transport|nervous system development|kinesin binding|cell differentiation KIFC1 1714.828722 1581.301399 1848.356045 1.168882825 0.225130313 0.490928132 1 26.74034636 32.60272758 3833 kinesin family member C1 "GO:0000070,GO:0003777,GO:0005524,GO:0005634,GO:0005769,GO:0005815,GO:0005871,GO:0005874,GO:0007018,GO:0007080,GO:0007283,GO:0008017,GO:0016020,GO:0016887,GO:0051301,GO:0072686,GO:0090307" mitotic sister chromatid segregation|microtubule motor activity|ATP binding|nucleus|early endosome|microtubule organizing center|kinesin complex|microtubule|microtubule-based movement|mitotic metaphase plate congression|spermatogenesis|microtubule binding|membrane|ATPase activity|cell division|mitotic spindle|mitotic spindle assembly KIFC2 1386.062414 1232.156546 1539.968283 1.249815446 0.321715075 0.336991304 1 15.97654435 20.82786082 90990 kinesin family member C2 "GO:0003777,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0072686,GO:0090307" microtubule motor activity|ATP binding|nucleus|cytoplasm|microtubule organizing center|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|mitotic spindle|mitotic spindle assembly KIFC3 2122.102938 2111.108414 2133.097462 1.010415878 0.014949215 0.964443886 1 20.01501191 21.09463158 3801 kinesin family member C3 "GO:0003777,GO:0005515,GO:0005524,GO:0005794,GO:0005813,GO:0005871,GO:0005874,GO:0005915,GO:0007018,GO:0007030,GO:0007601,GO:0008017,GO:0008569,GO:0030659,GO:0045218,GO:0070062,GO:0090136" "microtubule motor activity|protein binding|ATP binding|Golgi apparatus|centrosome|kinesin complex|microtubule|zonula adherens|microtubule-based movement|Golgi organization|visual perception|microtubule binding|ATP-dependent microtubule motor activity, minus-end-directed|cytoplasmic vesicle membrane|zonula adherens maintenance|extracellular exosome|epithelial cell-cell adhesion" KIN 222.6507069 234.4548287 210.8465851 0.899305791 -0.153116336 0.775090292 1 1.361264469 1.276926291 22944 Kin17 DNA and RNA binding protein "GO:0003677,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006281,GO:0006310,GO:0006397,GO:0006974,GO:0016032,GO:0016363,GO:0032991,GO:0043231,GO:0046872" DNA binding|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|DNA replication|DNA repair|DNA recombination|mRNA processing|cellular response to DNA damage stimulus|viral process|nuclear matrix|protein-containing complex|intracellular membrane-bounded organelle|metal ion binding KIRREL1 5756.370757 6329.265419 5183.476095 0.81896962 -0.288118159 0.373344619 1 42.58169038 36.37530297 55243 kirre like nephrin family adhesion molecule 1 "GO:0005515,GO:0005886,GO:0005887,GO:0005911,GO:0017022,GO:0031253,GO:0045121,GO:0048471,GO:0050839,GO:0098609" protein binding|plasma membrane|integral component of plasma membrane|cell-cell junction|myosin binding|cell projection membrane|membrane raft|perinuclear region of cytoplasm|cell adhesion molecule binding|cell-cell adhesion KISS1 6.015506931 7.104691779 4.926322083 0.693389979 -0.528261108 0.84291128 1 0.503960189 0.364493443 3814 KiSS-1 metastasis suppressor "GO:0005515,GO:0005576,GO:0007010,GO:0007186,GO:0007204,GO:0031773,GO:0043005" protein binding|extracellular region|cytoskeleton organization|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|kisspeptin receptor binding|neuron projection "hsa04080,hsa04929" Neuroactive ligand-receptor interaction|GnRH secretion KISS1R 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.090819681 0 84634 KISS1 receptor "GO:0005515,GO:0005886,GO:0005887,GO:0005929,GO:0007186,GO:0007218,GO:0008188,GO:0008528,GO:0009986,GO:0016021,GO:0043231" protein binding|plasma membrane|integral component of plasma membrane|cilium|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|neuropeptide receptor activity|G protein-coupled peptide receptor activity|cell surface|integral component of membrane|intracellular membrane-bounded organelle "hsa04080,hsa04929" Neuroactive ligand-receptor interaction|GnRH secretion KITLG 222.1783637 168.4826908 275.8740366 1.637402842 0.711409304 0.17259109 1 1.568287799 2.678534431 4254 KIT ligand "GO:0000165,GO:0001541,GO:0001755,GO:0002687,GO:0002763,GO:0005125,GO:0005173,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005856,GO:0005886,GO:0007155,GO:0008083,GO:0008284,GO:0008584,GO:0016021,GO:0030027,GO:0030175,GO:0033026,GO:0035162,GO:0035234,GO:0043406,GO:0045636,GO:0046579,GO:0050731,GO:0051897,GO:0070668,GO:0097192,GO:1901534,GO:1902035" MAPK cascade|ovarian follicle development|neural crest cell migration|positive regulation of leukocyte migration|positive regulation of myeloid leukocyte differentiation|cytokine activity|stem cell factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|cytoskeleton|plasma membrane|cell adhesion|growth factor activity|positive regulation of cell population proliferation|male gonad development|integral component of membrane|lamellipodium|filopodium|negative regulation of mast cell apoptotic process|embryonic hemopoiesis|ectopic germ cell programmed cell death|positive regulation of MAP kinase activity|positive regulation of melanocyte differentiation|positive regulation of Ras protein signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling|positive regulation of mast cell proliferation|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of hematopoietic progenitor cell differentiation|positive regulation of hematopoietic stem cell proliferation "hsa04010,hsa04014,hsa04015,hsa04072,hsa04151,hsa04640,hsa04916,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Hematopoietic cell lineage|Melanogenesis|Pathways in cancer KIZ 274.0747301 281.1428032 267.0066569 0.949718982 -0.074427406 0.885572654 1 6.013045258 5.956697156 55857 kizuna centrosomal protein "GO:0005515,GO:0005737,GO:0005813,GO:0007051,GO:0019901,GO:0042995" protein binding|cytoplasm|centrosome|spindle organization|protein kinase binding|cell projection KLC1 2585.100017 2509.98611 2660.213925 1.05985205 0.083862886 0.793369633 1 40.71811075 45.014123 3831 kinesin light chain 1 "GO:0003774,GO:0005515,GO:0005829,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0016020,GO:0016032,GO:0019886,GO:0030426,GO:0031410,GO:0035617" "motor activity|protein binding|cytosol|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|membrane|viral process|antigen processing and presentation of exogenous peptide antigen via MHC class II|growth cone|cytoplasmic vesicle|stress granule disassembly" "hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132" Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection KLC2 1927.958835 1771.098165 2084.819505 1.177133796 0.23527831 0.466815901 1 24.47472687 30.05104731 64837 kinesin light chain 2 "GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0005871,GO:0005874,GO:0005886,GO:0006890,GO:0007018,GO:0016020,GO:0016938,GO:0019886,GO:0019894,GO:0032991,GO:0045296" "protein binding|nucleoplasm|mitochondrion|cytosol|kinesin complex|microtubule|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|membrane|kinesin I complex|antigen processing and presentation of exogenous peptide antigen via MHC class II|kinesin binding|protein-containing complex|cadherin binding" "hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132" Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection KLC3 10.3898137 3.044867905 17.7347595 5.824475823 2.542128219 0.086398849 1 0.079164177 0.480951718 147700 kinesin light chain 3 "GO:0005515,GO:0005737,GO:0005871,GO:0005874,GO:0008017,GO:0008088,GO:0019894,GO:0031514,GO:0035253,GO:0043005" protein binding|cytoplasm|kinesin complex|microtubule|microtubule binding|axo-dendritic transport|kinesin binding|motile cilium|ciliary rootlet|neuron projection "hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132" Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection KLC4 308.2148102 291.2923629 325.1372575 1.116188747 0.158581006 0.739956052 1 5.211208253 6.067251509 89953 kinesin light chain 4 "GO:0005515,GO:0005737,GO:0005871,GO:0005874" protein binding|cytoplasm|kinesin complex|microtubule "hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132" Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection KLF10 2125.056502 1403.684104 2846.428899 2.027827266 1.019934766 0.001632277 0.125704511 22.2927714 47.15317606 7071 Kruppel like factor 10 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001046,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007267,GO:0007623,GO:0008285,GO:0009267,GO:0030282,GO:0035019,GO:0042752,GO:0045672,GO:0045892,GO:0045944,GO:0046872,GO:1901653,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|core promoter sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|cell-cell signaling|circadian rhythm|negative regulation of cell population proliferation|cellular response to starvation|bone mineralization|somatic stem cell population maintenance|regulation of circadian rhythm|positive regulation of osteoclast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to peptide|sequence-specific double-stranded DNA binding" zf-C2H2 KLF11 139.480979 105.5554207 173.4065373 1.642800873 0.716157619 0.238833432 1 1.236071603 2.118090361 8462 Kruppel like factor 11 "GO:0000083,GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006357,GO:0006915,GO:0008285,GO:0016604,GO:0043065,GO:0046872,GO:1901653,GO:1990837" "regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|focal adhesion|regulation of transcription by RNA polymerase II|apoptotic process|negative regulation of cell population proliferation|nuclear body|positive regulation of apoptotic process|metal ion binding|cellular response to peptide|sequence-specific double-stranded DNA binding" KLF12 691.1315667 570.4052542 811.8578792 1.423300142 0.509239926 0.178992623 1 2.449882451 3.637120327 11278 Kruppel like factor 12 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 KLF13 1617.85589 1384.399941 1851.311839 1.337266627 0.419287141 0.202139221 1 9.818649088 13.69574543 51621 Kruppel like factor 13 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0008285,GO:0045647,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|negative regulation of cell population proliferation|negative regulation of erythrocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" KLF14 16.50924106 17.25425146 15.76423066 0.913643266 -0.130297123 0.968240693 1 0.248894038 0.237195847 136259 Kruppel like factor 14 "GO:0000785,GO:0000978,GO:0000981,GO:0003682,GO:0005634,GO:0006357,GO:0043565,GO:0045944,GO:0046872,GO:1902070,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|chromatin binding|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of sphingolipid mediated signaling pathway|sequence-specific double-stranded DNA binding" KLF15 5.015396738 6.08973581 3.941057666 0.64716398 -0.627796782 0.826813936 1 0.105769422 0.071398716 28999 Kruppel like factor 15 "GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001678,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0010001,GO:0014898,GO:0016607,GO:0030111,GO:0032868,GO:0043231,GO:0045944,GO:0046326,GO:0046872,GO:0072112,GO:1901653,GO:1990837,GO:2000757" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cellular glucose homeostasis|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|glial cell differentiation|cardiac muscle hypertrophy in response to stress|nuclear speck|regulation of Wnt signaling pathway|response to insulin|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|metal ion binding|glomerular visceral epithelial cell differentiation|cellular response to peptide|sequence-specific double-stranded DNA binding|negative regulation of peptidyl-lysine acetylation" zf-C2H2 KLF16 532.634886 613.0334049 452.2363672 0.73770265 -0.438888677 0.2754423 1 10.70250924 8.235365612 83855 Kruppel like factor 16 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0007212,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|dopamine receptor signaling pathway|metal ion binding|sequence-specific double-stranded DNA binding" KLF17 6.478447587 5.074779842 7.882115332 1.553193553 0.635237624 0.773446698 1 0.064238864 0.104073309 128209 Kruppel like factor 17 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" KLF2 115.7752499 101.4955968 130.054903 1.281384681 0.357703648 0.585200746 1 1.822834725 2.436367237 10365 Kruppel like factor 2 "GO:0000122,GO:0000785,GO:0000902,GO:0000978,GO:0000981,GO:0001701,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0032715,GO:0035264,GO:0036003,GO:0040029,GO:0042311,GO:0043249,GO:0045429,GO:0045893,GO:0045944,GO:0046872,GO:0048386,GO:0051247,GO:0060509,GO:0070301,GO:0071347,GO:0071356,GO:0071409,GO:0071498,GO:0071499,GO:0097533,GO:1901653,GO:1903671,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|in utero embryonic development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|negative regulation of interleukin-6 production|multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter in response to stress|regulation of gene expression, epigenetic|vasodilation|erythrocyte maturation|positive regulation of nitric oxide biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of retinoic acid receptor signaling pathway|positive regulation of protein metabolic process|type I pneumocyte differentiation|cellular response to hydrogen peroxide|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to cycloheximide|cellular response to fluid shear stress|cellular response to laminar fluid shear stress|cellular stress response to acid chemical|cellular response to peptide|negative regulation of sprouting angiogenesis|sequence-specific double-stranded DNA binding" "hsa04068,hsa04371,hsa05418" FoxO signaling pathway|Apelin signaling pathway|Fluid shear stress and atherosclerosis KLF3 760.1634184 709.4542219 810.8726148 1.142952695 0.192765694 0.605045765 1 6.05108682 7.214023784 51274 Kruppel like factor 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0007275,GO:0046872,GO:1901653,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding|cellular response to peptide|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer zf-C2H2 KLF4 243.231896 294.3372308 192.1265612 0.65274298 -0.615413058 0.224057998 1 4.906893477 3.340909948 9314 Kruppel like factor 4 "GO:0000122,GO:0000785,GO:0000791,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001010,GO:0001085,GO:0001221,GO:0001228,GO:0003700,GO:0005515,GO:0005654,GO:0005667,GO:0005737,GO:0006351,GO:0006357,GO:0007500,GO:0008013,GO:0008270,GO:0008285,GO:0009913,GO:0010628,GO:0010629,GO:0014067,GO:0014740,GO:0016525,GO:0019827,GO:0031077,GO:0032088,GO:0032270,GO:0032717,GO:0034115,GO:0035014,GO:0035019,GO:0035166,GO:0042826,GO:0043154,GO:0043551,GO:0045429,GO:0045444,GO:0045595,GO:0045892,GO:0045893,GO:0045944,GO:0046985,GO:0048662,GO:0048679,GO:0048730,GO:0050728,GO:0051247,GO:0051898,GO:0051973,GO:0060070,GO:0060761,GO:0070301,GO:0070373,GO:0071300,GO:0071363,GO:0071409,GO:0071499,GO:0090051,GO:0120222,GO:1901653,GO:1902895,GO:1903672,GO:1904798,GO:1904998,GO:1990830,GO:1990837,GO:1990841,GO:2000134,GO:2000342" "negative regulation of transcription by RNA polymerase II|chromatin|euchromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity|RNA polymerase II transcription factor binding|transcription coregulator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|transcription regulator complex|cytoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|mesodermal cell fate determination|beta-catenin binding|zinc ion binding|negative regulation of cell population proliferation|epidermal cell differentiation|positive regulation of gene expression|negative regulation of gene expression|negative regulation of phosphatidylinositol 3-kinase signaling|negative regulation of muscle hyperplasia|negative regulation of angiogenesis|stem cell population maintenance|post-embryonic camera-type eye development|negative regulation of NF-kappaB transcription factor activity|positive regulation of cellular protein metabolic process|negative regulation of interleukin-8 production|negative regulation of heterotypic cell-cell adhesion|phosphatidylinositol 3-kinase regulator activity|somatic stem cell population maintenance|post-embryonic hemopoiesis|histone deacetylase binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of phosphatidylinositol 3-kinase activity|positive regulation of nitric oxide biosynthetic process|fat cell differentiation|regulation of cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of hemoglobin biosynthetic process|negative regulation of smooth muscle cell proliferation|regulation of axon regeneration|epidermis morphogenesis|negative regulation of inflammatory response|positive regulation of protein metabolic process|negative regulation of protein kinase B signaling|positive regulation of telomerase activity|canonical Wnt signaling pathway|negative regulation of response to cytokine stimulus|cellular response to hydrogen peroxide|negative regulation of ERK1 and ERK2 cascade|cellular response to retinoic acid|cellular response to growth factor stimulus|cellular response to cycloheximide|cellular response to laminar fluid shear stress|negative regulation of cell migration involved in sprouting angiogenesis|regulation of blastocyst development|cellular response to peptide|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of sprouting angiogenesis|positive regulation of core promoter binding|negative regulation of leukocyte adhesion to arterial endothelial cell|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of chemokine (C-X-C motif) ligand 2 production" hsa04550 Signaling pathways regulating pluripotency of stem cells zf-C2H2 KLF5 445.4850064 414.1020351 476.8679776 1.1515712 0.203603614 0.631245032 1 5.937940887 7.132513373 688 Kruppel like factor 5 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0005515,GO:0005654,GO:0005667,GO:0005794,GO:0006357,GO:0008284,GO:0014816,GO:0014901,GO:0014908,GO:0030033,GO:0032534,GO:0043231,GO:0043426,GO:0045600,GO:0045944,GO:0046872,GO:0060576,GO:0061586,GO:0071407,GO:0099156,GO:1901653,GO:1902895,GO:1990830,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|protein binding|nucleoplasm|transcription regulator complex|Golgi apparatus|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|skeletal muscle satellite cell differentiation|satellite cell activation involved in skeletal muscle regeneration|myotube differentiation involved in skeletal muscle regeneration|microvillus assembly|regulation of microvillus assembly|intracellular membrane-bounded organelle|MRF binding|positive regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|intestinal epithelial cell development|positive regulation of transcription by transcription factor localization|cellular response to organic cyclic compound|cell-cell signaling via exosome|cellular response to peptide|positive regulation of pri-miRNA transcription by RNA polymerase II|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" zf-C2H2 KLF6 3748.361783 3699.514505 3797.209061 1.026407399 0.037603476 0.906756649 1 40.82077529 43.70357384 1316 Kruppel like factor 6 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0030183,GO:0043231,GO:0045893,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|B cell differentiation|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 KLF7 593.9048724 558.2257826 629.5839622 1.127830318 0.173550031 0.660147634 1 1.638016604 1.926983494 8609 Kruppel like factor 7 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007409,GO:0007411,GO:0008270,GO:0042593,GO:0045604,GO:0045944,GO:0048813,GO:0061179,GO:1904178" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|axonogenesis|axon guidance|zinc ion binding|glucose homeostasis|regulation of epidermal cell differentiation|positive regulation of transcription by RNA polymerase II|dendrite morphogenesis|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of adipose tissue development" zf-C2H2 KLF8 170.484395 137.0190557 203.9497342 1.488477155 0.573837079 0.313308909 1 0.670097702 1.040390149 11279 Kruppel like factor 8 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005654,GO:0005829,GO:0006357,GO:0016235,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|aggresome|metal ion binding" KLF9 314.5596458 287.232539 341.8867525 1.190278628 0.251299328 0.592565956 1 2.797022651 3.472646281 687 Kruppel like factor 9 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0007623,GO:0010839,GO:0046872,GO:0071387,GO:0097067" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|circadian rhythm|negative regulation of keratinocyte proliferation|metal ion binding|cellular response to cortisol stimulus|cellular response to thyroid hormone stimulus" zf-C2H2 KLHDC1 46.87156706 38.5683268 55.17480733 1.430573009 0.516593127 0.559919727 1 0.264825067 0.395170983 122773 kelch domain containing 1 GO:0005829 cytosol KLHDC10 1298.190289 1286.964168 1309.41641 1.017445895 0.024952078 0.943539427 1 10.18440546 10.80843798 23008 kelch domain containing 10 "GO:0005515,GO:0005654,GO:0005737,GO:0032874" protein binding|nucleoplasm|cytoplasm|positive regulation of stress-activated MAPK cascade KLHDC2 834.1473243 715.5439577 952.7506908 1.331505466 0.413058351 0.257101539 1 10.78885894 14.98422888 23588 kelch domain containing 2 "GO:0005515,GO:0005654,GO:0016604,GO:0031965" protein binding|nucleoplasm|nuclear body|nuclear membrane KLHDC3 1546.323021 1343.801702 1748.844339 1.301415482 0.380081621 0.250005224 1 33.3458185 45.26612106 116138 kelch domain containing 3 "GO:0000785,GO:0003682,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007131,GO:0036498" chromatin|chromatin binding|protein binding|nucleoplasm|cytoplasm|cytosol|reciprocal meiotic recombination|IRE1-mediated unfolded protein response KLHDC4 354.4128741 351.1747651 357.6509832 1.018441582 0.026363229 0.960010348 1 2.932041375 3.114742487 54758 kelch domain containing 4 GO:0005515 protein binding KLHDC8B 420.3689285 313.6213942 527.1164629 1.680741405 0.749097772 0.080458457 1 6.428092767 11.26935252 200942 kelch domain containing 8B "GO:0005737,GO:0005829,GO:0030496,GO:0045171,GO:0098813,GO:0110070,GO:0140014,GO:1902410" cytoplasm|cytosol|midbody|intercellular bridge|nuclear chromosome segregation|cellularization cleavage furrow|mitotic nuclear division|mitotic cytokinetic process KLHDC9 64.57391341 70.03196182 59.11586499 0.844126931 -0.244468142 0.769138752 1 2.596538659 2.286222418 126823 kelch domain containing 9 "GO:0005515,GO:0005575,GO:0008150,GO:0030332" protein binding|cellular_component|biological_process|cyclin binding KLHL10 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.068456375 317719 kelch like family member 10 "GO:0000902,GO:0005515,GO:0005737,GO:0007286,GO:0008584,GO:0009566,GO:0016567,GO:0048808,GO:0048873" cell morphogenesis|protein binding|cytoplasm|spermatid development|male gonad development|fertilization|protein ubiquitination|male genitalia morphogenesis|homeostasis of number of cells within a tissue KLHL11 280.4937945 282.1577592 278.8298299 0.98820543 -0.017117111 0.97997792 1 1.930599177 1.990010109 55175 kelch like family member 11 "GO:0005515,GO:0005829,GO:0043687" protein binding|cytosol|post-translational protein modification KLHL12 1019.822162 1116.451565 923.1927583 0.826899068 -0.274216852 0.435345117 1 16.22505973 13.9944146 59349 kelch like family member 12 "GO:0000139,GO:0005515,GO:0005829,GO:0006513,GO:0006888,GO:0014029,GO:0014032,GO:0016055,GO:0030127,GO:0030134,GO:0031463,GO:0034451,GO:0042802,GO:0043231,GO:0048208,GO:0090090" Golgi membrane|protein binding|cytosol|protein monoubiquitination|endoplasmic reticulum to Golgi vesicle-mediated transport|neural crest formation|neural crest cell development|Wnt signaling pathway|COPII vesicle coat|COPII-coated ER to Golgi transport vesicle|Cul3-RING ubiquitin ligase complex|centriolar satellite|identical protein binding|intracellular membrane-bounded organelle|COPII vesicle coating|negative regulation of canonical Wnt signaling pathway KLHL13 243.2197719 259.8287279 226.6108158 0.872154583 -0.19734423 0.701392157 1 2.568190564 2.336343219 90293 kelch like family member 13 "GO:0004842,GO:0005515,GO:0005829,GO:0007049,GO:0016567,GO:0030496,GO:0031463,GO:0032465,GO:0043687,GO:0047485,GO:0051301,GO:0097602" ubiquitin-protein transferase activity|protein binding|cytosol|cell cycle|protein ubiquitination|midbody|Cul3-RING ubiquitin ligase complex|regulation of cytokinesis|post-translational protein modification|protein N-terminus binding|cell division|cullin family protein binding hsa04120 Ubiquitin mediated proteolysis KLHL14 18.15044122 28.41876711 7.882115332 0.277355992 -1.850189203 0.115101104 1 0.171530247 0.049624277 57565 kelch like family member 14 "GO:0005783,GO:0005789,GO:0005829,GO:0015629,GO:0016235,GO:0043005,GO:0043025" endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|actin cytoskeleton|aggresome|neuron projection|neuronal cell body KLHL15 319.5211026 222.2753571 416.7668482 1.875002491 0.906892512 0.051353583 1 1.794876068 3.510364756 80311 kelch like family member 15 "GO:0005515,GO:0005634,GO:0006511,GO:0016567,GO:0031463,GO:0071630,GO:2000042" protein binding|nucleus|ubiquitin-dependent protein catabolic process|protein ubiquitination|Cul3-RING ubiquitin ligase complex|nuclear protein quality control by the ubiquitin-proteasome system|negative regulation of double-strand break repair via homologous recombination KLHL17 402.2076009 419.1768149 385.2383869 0.919035531 -0.121807455 0.782822243 1 6.478433601 6.210380992 339451 kelch like family member 17 "GO:0005515,GO:0005615,GO:0007420,GO:0014069,GO:0015629,GO:0016567,GO:0030036,GO:0031208,GO:0032839,GO:0043025,GO:0051015,GO:0060090" protein binding|extracellular space|brain development|postsynaptic density|actin cytoskeleton|protein ubiquitination|actin cytoskeleton organization|POZ domain binding|dendrite cytoplasm|neuronal cell body|actin filament binding|molecular adaptor activity KLHL18 733.6746021 784.5609636 682.7882407 0.87028067 -0.200447343 0.59338749 1 8.534202113 7.747082678 23276 kelch like family member 18 "GO:0005515,GO:0007049,GO:0016567,GO:0051301,GO:1901992" protein binding|cell cycle|protein ubiquitination|cell division|positive regulation of mitotic cell cycle phase transition KLHL2 240.9523275 239.5296085 242.3750465 1.011879274 0.017037175 0.982390993 1 3.125020521 3.298355815 11275 kelch like family member 2 "GO:0001726,GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0015629,GO:0016567,GO:0030027,GO:0031463,GO:0042802,GO:0043687" ruffle|actin binding|protein binding|cytoplasm|cytosol|actin cytoskeleton|protein ubiquitination|lamellipodium|Cul3-RING ubiquitin ligase complex|identical protein binding|post-translational protein modification KLHL20 456.5280342 461.8049656 451.2511028 0.977146493 -0.033353228 0.941941104 1 5.797915805 5.909456117 27252 kelch like family member 20 "GO:0003779,GO:0004842,GO:0005515,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0006895,GO:0007010,GO:0015031,GO:0015629,GO:0016567,GO:0016605,GO:0019964,GO:0030424,GO:0030425,GO:0031463,GO:0035455,GO:0043066,GO:0043161,GO:0043687,GO:0048471,GO:1990390" actin binding|ubiquitin-protein transferase activity|protein binding|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|Golgi to endosome transport|cytoskeleton organization|protein transport|actin cytoskeleton|protein ubiquitination|PML body|interferon-gamma binding|axon|dendrite|Cul3-RING ubiquitin ligase complex|response to interferon-alpha|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|perinuclear region of cytoplasm|protein K33-linked ubiquitination KLHL21 1180.659032 1301.173551 1060.144512 0.814760269 -0.295552465 0.389000525 1 13.34275159 11.33942866 9903 kelch like family member 21 "GO:0004842,GO:0005515,GO:0005827,GO:0005829,GO:0007049,GO:0016567,GO:0031463,GO:0032465,GO:0035853,GO:0043687,GO:0051301,GO:0097602" ubiquitin-protein transferase activity|protein binding|polar microtubule|cytosol|cell cycle|protein ubiquitination|Cul3-RING ubiquitin ligase complex|regulation of cytokinesis|chromosome passenger complex localization to spindle midzone|post-translational protein modification|cell division|cullin family protein binding KLHL22 379.4156289 376.5486643 382.2825936 1.015227592 0.021803184 0.96706459 1 4.199705233 4.447317665 84861 kelch like family member 22 "GO:0000070,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005813,GO:0005827,GO:0005829,GO:0006513,GO:0007094,GO:0010507,GO:0015630,GO:0030307,GO:0031463,GO:0043161,GO:0043231,GO:0043687,GO:0045171,GO:0051301,GO:0071233,GO:0071889,GO:0072686,GO:1904263" mitotic sister chromatid segregation|protein binding|nucleus|cytoplasm|lysosome|centrosome|polar microtubule|cytosol|protein monoubiquitination|mitotic spindle assembly checkpoint|negative regulation of autophagy|microtubule cytoskeleton|positive regulation of cell growth|Cul3-RING ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|post-translational protein modification|intercellular bridge|cell division|cellular response to leucine|14-3-3 protein binding|mitotic spindle|positive regulation of TORC1 signaling KLHL23 7.986035764 7.104691779 8.867379749 1.248101962 0.319735798 0.916631795 1 0.088171422 0.114787301 151230 kelch like family member 23 GO:0005515 protein binding KLHL24 739.5080004 644.4970399 834.5189608 1.294837539 0.372771096 0.318303382 1 4.531024628 6.119664792 54800 kelch like family member 24 "GO:0005515,GO:0005737,GO:0005912,GO:0016567,GO:0030057,GO:0030424,GO:0031463,GO:0043204,GO:0045109,GO:0051865,GO:2000312" protein binding|cytoplasm|adherens junction|protein ubiquitination|desmosome|axon|Cul3-RING ubiquitin ligase complex|perikaryon|intermediate filament organization|protein autoubiquitination|regulation of kainate selective glutamate receptor activity KLHL25 302.6325524 280.1278473 325.1372575 1.16067453 0.214963476 0.652225651 1 3.886982803 4.705860006 64410 kelch like family member 25 "GO:0005737,GO:0005829,GO:0006446,GO:0006511,GO:0016567,GO:0031463,GO:0043687" cytoplasm|cytosol|regulation of translational initiation|ubiquitin-dependent protein catabolic process|protein ubiquitination|Cul3-RING ubiquitin ligase complex|post-translational protein modification KLHL26 193.3505958 184.7219862 201.9792054 1.093422659 0.128851178 0.82101785 1 1.973321439 2.250618237 55295 kelch like family member 26 GO:0005515 protein binding KLHL28 328.1603525 274.0381115 382.2825936 1.394997913 0.480262964 0.296836275 1 1.802944089 2.623443689 54813 kelch like family member 28 KLHL29 487.652938 467.8947014 507.4111745 1.084455911 0.1169714 0.779814787 1 3.417539082 3.86581725 114818 kelch like family member 29 GO:0005515 protein binding KLHL31 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.028793692 0.014577696 401265 kelch like family member 31 "GO:0001933,GO:0005634,GO:0005737,GO:0046329" negative regulation of protein phosphorylation|nucleus|cytoplasm|negative regulation of JNK cascade KLHL35 43.0492756 46.68797455 39.41057666 0.844126931 -0.244468142 0.803823244 1 1.12599105 0.991422166 283212 kelch like family member 35 GO:0005515 protein binding KLHL36 686.0013631 691.1850145 680.8177118 0.985000684 -0.021803369 0.95830544 1 4.424429048 4.54579343 79786 kelch like family member 36 "GO:0005515,GO:0005575,GO:0008150,GO:0016567,GO:0097602" protein binding|cellular_component|biological_process|protein ubiquitination|cullin family protein binding KLHL41 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.188063192 0.0846336 10324 kelch like family member 41 "GO:0001726,GO:0005515,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0006941,GO:0016567,GO:0030239,GO:0031143,GO:0031275,GO:0031430,GO:0031463,GO:0033017,GO:0035914,GO:0043687,GO:0045214,GO:0045661,GO:0048741,GO:2000291,GO:2001014" ruffle|protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|cytoskeleton|plasma membrane|striated muscle contraction|protein ubiquitination|myofibril assembly|pseudopodium|regulation of lateral pseudopodium assembly|M band|Cul3-RING ubiquitin ligase complex|sarcoplasmic reticulum membrane|skeletal muscle cell differentiation|post-translational protein modification|sarcomere organization|regulation of myoblast differentiation|skeletal muscle fiber development|regulation of myoblast proliferation|regulation of skeletal muscle cell differentiation KLHL42 1810.933818 1617.839814 2004.027823 1.238705962 0.308833769 0.341898214 1 11.77606772 15.21543777 57542 kelch like family member 42 "GO:0000209,GO:0004842,GO:0005515,GO:0005819,GO:0005829,GO:0007049,GO:0031463,GO:0032886,GO:0043161,GO:0043687,GO:0051301" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|spindle|cytosol|cell cycle|Cul3-RING ubiquitin ligase complex|regulation of microtubule-based process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|cell division KLHL5 2858.62001 2820.562636 2896.677385 1.026985661 0.038416039 0.904970054 1 12.84405207 13.75885734 51088 kelch like family member 5 "GO:0003674,GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0008150,GO:0043687" molecular_function|actin binding|protein binding|cytoplasm|cytosol|cytoskeleton|biological_process|post-translational protein modification KLHL7 623.1752919 605.9287131 640.4218708 1.056926099 0.079874505 0.840282806 1 4.453366961 4.909633059 55975 kelch like family member 7 "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0016567,GO:0031463,GO:0042802,GO:0042803,GO:0048471" protein binding|nucleoplasm|nucleolus|cytosol|plasma membrane|protein ubiquitination|Cul3-RING ubiquitin ligase complex|identical protein binding|protein homodimerization activity|perinuclear region of cytoplasm KLHL8 283.1026917 325.8008658 240.4045176 0.737887903 -0.438526431 0.363428428 1 2.813412532 2.165408004 57563 kelch like family member 8 "GO:0005654,GO:0006511,GO:0016567,GO:0031463" nucleoplasm|ubiquitin-dependent protein catabolic process|protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL9 913.1693914 998.7166729 827.6221099 0.828685585 -0.271103269 0.449614886 1 8.812103871 7.617023957 55958 kelch like family member 9 "GO:0004842,GO:0005829,GO:0007049,GO:0016567,GO:0030496,GO:0031463,GO:0032465,GO:0043687,GO:0051301,GO:0097602" ubiquitin-protein transferase activity|cytosol|cell cycle|protein ubiquitination|midbody|Cul3-RING ubiquitin ligase complex|regulation of cytokinesis|post-translational protein modification|cell division|cullin family protein binding hsa04120 Ubiquitin mediated proteolysis KLK1 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.084086694 3816 kallikrein 1 "GO:0003073,GO:0004252,GO:0005634,GO:0030141,GO:0031638,GO:0070062" regulation of systemic arterial blood pressure|serine-type endopeptidase activity|nucleus|secretory granule|zymogen activation|extracellular exosome "hsa04614,hsa04961" Renin-angiotensin system|Endocrine and other factor-regulated calcium reabsorption KLLN 27.19597028 40.59823873 13.79370183 0.33976109 -1.557407454 0.130222134 1 0.469871474 0.166520862 100144748 "killin, p53 regulated DNA replication inhibitor" "GO:0003677,GO:0005654,GO:0005730,GO:0006915,GO:0007050" DNA binding|nucleoplasm|nucleolus|apoptotic process|cell cycle arrest KLRC1 9.597544372 16.23929549 2.95579325 0.182014869 -2.457871781 0.104356556 1 0.35013326 0.066474666 3821 killer cell lectin like receptor C1 "GO:0001915,GO:0002305,GO:0002769,GO:0004888,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0023024,GO:0030246,GO:0043235,GO:0045953,GO:0050776,GO:0062082,GO:1990405" "negative regulation of T cell mediated cytotoxicity|CD8-positive, gamma-delta intraepithelial T cell differentiation|natural killer cell inhibitory signaling pathway|transmembrane signaling receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|MHC class I protein complex binding|carbohydrate binding|receptor complex|negative regulation of natural killer cell mediated cytotoxicity|regulation of immune response|HLA-E specific inhibitory MHC class Ib receptor activity|protein antigen binding" "hsa04612,hsa04650,hsa05332" Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Graft-versus-host disease KLRC2 110.6235196 119.7648043 101.4822349 0.847346059 -0.238976803 0.724433419 1 4.899567715 4.330464751 3822 killer cell lectin like receptor C2 "GO:0002223,GO:0002228,GO:0004888,GO:0005515,GO:0005886,GO:0005887,GO:0006968,GO:0007165,GO:0023024,GO:0030246,GO:0043235,GO:0043323,GO:0045087,GO:0045954,GO:0062081,GO:1990405" stimulatory C-type lectin receptor signaling pathway|natural killer cell mediated immunity|transmembrane signaling receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cellular defense response|signal transduction|MHC class I protein complex binding|carbohydrate binding|receptor complex|positive regulation of natural killer cell degranulation|innate immune response|positive regulation of natural killer cell mediated cytotoxicity|activating MHC class Ib receptor activity|protein antigen binding "hsa04612,hsa04650" Antigen processing and presentation|Natural killer cell mediated cytotoxicity KLRC3 22.56928532 27.40381115 17.7347595 0.64716398 -0.627796782 0.575563072 1 1.212145292 0.818247988 3823 killer cell lectin like receptor C3 "GO:0004888,GO:0006968,GO:0016021,GO:0030246" transmembrane signaling receptor activity|cellular defense response|integral component of membrane|carbohydrate binding "hsa04612,hsa04650" Antigen processing and presentation|Natural killer cell mediated cytotoxicity KLRC4 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.221568704 0.224351999 8302 killer cell lectin like receptor C4 GO:0016021 integral component of membrane hsa04612 Antigen processing and presentation KLRG1 15.56851397 20.29911937 10.83790858 0.533910284 -0.905330758 0.466566058 1 0.303357564 0.16894255 10219 killer cell lectin like receptor G1 "GO:0005515,GO:0005886,GO:0006954,GO:0006968,GO:0007166,GO:0016021,GO:0030246,GO:0038023,GO:0043231,GO:0045087" protein binding|plasma membrane|inflammatory response|cellular defense response|cell surface receptor signaling pathway|integral component of membrane|carbohydrate binding|signaling receptor activity|intracellular membrane-bounded organelle|innate immune response KMT2A 5004.977971 4973.284245 5036.671697 1.012745592 0.018271806 0.955269777 1 17.26146535 18.2345039 4297 lysine methyltransferase 2A "GO:0003680,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006915,GO:0008270,GO:0032411,GO:0032922,GO:0035097,GO:0035162,GO:0042800,GO:0042802,GO:0042803,GO:0043984,GO:0044648,GO:0045322,GO:0045652,GO:0045893,GO:0045944,GO:0051568,GO:0051571,GO:0065003,GO:0070577,GO:0071339,GO:0071440,GO:0080182,GO:0097692,GO:1902036,GO:1905642,GO:2000615" "minor groove of adenine-thymine-rich DNA binding|protein binding|nucleus|nucleoplasm|cytosol|apoptotic process|zinc ion binding|positive regulation of transporter activity|circadian regulation of gene expression|histone methyltransferase complex|embryonic hemopoiesis|histone methyltransferase activity (H3-K4 specific)|identical protein binding|protein homodimerization activity|histone H4-K16 acetylation|histone H3-K4 dimethylation|unmethylated CpG binding|regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|histone H3-K4 methylation|positive regulation of histone H3-K4 methylation|protein-containing complex assembly|lysine-acetylated histone binding|MLL1 complex|regulation of histone H3-K14 acetylation|histone H3-K4 trimethylation|histone H3-K4 monomethylation|regulation of hematopoietic stem cell differentiation|negative regulation of DNA methylation|regulation of histone H3-K9 acetylation" "hsa00310,hsa04934,hsa05202" Lysine degradation|Cushing syndrome|Transcriptional misregulation in cancer other KMT2B 1185.468072 1091.077666 1279.858477 1.17302234 0.23023049 0.502285483 1 6.30741179 7.717442433 9757 lysine methyltransferase 2B "GO:0005515,GO:0005634,GO:0005654,GO:0008270,GO:0035097,GO:0042800,GO:0044648,GO:0045322,GO:0045652,GO:0045893,GO:0051568,GO:0097692" "protein binding|nucleus|nucleoplasm|zinc ion binding|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|histone H3-K4 dimethylation|unmethylated CpG binding|regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|histone H3-K4 methylation|histone H3-K4 monomethylation" hsa00310 Lysine degradation other KMT2C 2363.700315 2495.776726 2231.623903 0.894160075 -0.161394966 0.613943842 1 7.180316213 6.696914809 58508 lysine methyltransferase 2C "GO:0003677,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0016746,GO:0035097,GO:0042054,GO:0042393,GO:0042800,GO:0044666,GO:0045652,GO:0045944,GO:0046872,GO:0097692" "DNA binding|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|transferase activity, transferring acyl groups|histone methyltransferase complex|histone methyltransferase activity|histone binding|histone methyltransferase activity (H3-K4 specific)|MLL3/4 complex|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|histone H3-K4 monomethylation" hsa00310 Lysine degradation KMT2D 5551.242018 5406.670444 5695.813592 1.053478967 0.07516151 0.816295675 1 13.23163974 14.5397007 8085 lysine methyltransferase 2D "GO:0000976,GO:0001555,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006342,GO:0006355,GO:0008284,GO:0033148,GO:0035097,GO:0042393,GO:0042800,GO:0043627,GO:0044648,GO:0044666,GO:0045652,GO:0045944,GO:0046872,GO:0048477,GO:0051568,GO:0080182,GO:0097692,GO:1904837" "transcription regulatory region sequence-specific DNA binding|oocyte growth|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|chromatin silencing|regulation of transcription, DNA-templated|positive regulation of cell population proliferation|positive regulation of intracellular estrogen receptor signaling pathway|histone methyltransferase complex|histone binding|histone methyltransferase activity (H3-K4 specific)|response to estrogen|histone H3-K4 dimethylation|MLL3/4 complex|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|oogenesis|histone H3-K4 methylation|histone H3-K4 trimethylation|histone H3-K4 monomethylation|beta-catenin-TCF complex assembly" "hsa00310,hsa04934" Lysine degradation|Cushing syndrome other KMT2E 2146.916657 2258.27703 2035.556285 0.901375809 -0.149799363 0.641163245 1 11.34210282 10.6638839 55904 lysine methyltransferase 2E (inactive) "GO:0000785,GO:0002446,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005815,GO:0005886,GO:0006306,GO:0007050,GO:0016604,GO:0016607,GO:0018024,GO:0019899,GO:0030218,GO:0032991,GO:0034968,GO:0035064,GO:0035327,GO:0042119,GO:0045652,GO:0045893,GO:0046872,GO:1900087,GO:1905437" "chromatin|neutrophil mediated immunity|protein binding|nucleus|nucleoplasm|cytoplasm|microtubule organizing center|plasma membrane|DNA methylation|cell cycle arrest|nuclear body|nuclear speck|histone-lysine N-methyltransferase activity|enzyme binding|erythrocyte differentiation|protein-containing complex|histone lysine methylation|methylated histone binding|transcriptionally active chromatin|neutrophil activation|regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|metal ion binding|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of histone H3-K4 trimethylation" hsa00310 Lysine degradation KMT5A 1327.821212 1123.556257 1532.086168 1.363604322 0.447425077 0.184446463 1 17.7603498 25.26130682 387893 lysine methyltransferase 5A "GO:0000122,GO:0002039,GO:0003714,GO:0005515,GO:0005654,GO:0005694,GO:0005829,GO:0007049,GO:0016278,GO:0016279,GO:0018024,GO:0018026,GO:0034770,GO:0042799,GO:0043516,GO:0045892,GO:0051301,GO:1901796" "negative regulation of transcription by RNA polymerase II|p53 binding|transcription corepressor activity|protein binding|nucleoplasm|chromosome|cytosol|cell cycle|lysine N-methyltransferase activity|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|histone H4-K20 methylation|histone methyltransferase activity (H4-K20 specific)|regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription, DNA-templated|cell division|regulation of signal transduction by p53 class mediator" hsa00310 Lysine degradation KMT5B 792.49083 797.7553911 787.2262688 0.986801565 -0.019168091 0.962180006 1 5.514330046 5.675949407 51111 lysine methyltransferase 5B "GO:0000779,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0007517,GO:0018024,GO:0034773,GO:0042799,GO:0045830,GO:0046872,GO:1904047,GO:2001034" "condensed chromosome, centromeric region|chromatin binding|protein binding|nucleus|nucleoplasm|DNA repair|muscle organ development|histone-lysine N-methyltransferase activity|histone H4-K20 trimethylation|histone methyltransferase activity (H4-K20 specific)|positive regulation of isotype switching|metal ion binding|S-adenosyl-L-methionine binding|positive regulation of double-strand break repair via nonhomologous end joining" hsa00310 Lysine degradation KMT5C 166.9765864 132.9592319 200.993941 1.511696015 0.596168059 0.298082908 1 2.124934062 3.350625243 84787 lysine methyltransferase 5C "GO:0000779,GO:0000792,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0006281,GO:0034773,GO:0042393,GO:0042799,GO:0045830,GO:0046872,GO:1904047,GO:2001034" "condensed chromosome, centromeric region|heterochromatin|chromatin binding|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|DNA repair|histone H4-K20 trimethylation|histone binding|histone methyltransferase activity (H4-K20 specific)|positive regulation of isotype switching|metal ion binding|S-adenosyl-L-methionine binding|positive regulation of double-strand break repair via nonhomologous end joining" hsa00310 Lysine degradation KNL1 1371.553394 1216.932206 1526.174581 1.254116354 0.326671204 0.33029164 1 6.43286955 8.415084968 57082 kinetochore scaffold 1 "GO:0000777,GO:0001669,GO:0001675,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0008608,GO:0010923,GO:0016604,GO:0034080,GO:0034501,GO:0051301" condensed chromosome kinetochore|acrosomal vesicle|acrosome assembly|protein binding|nucleus|nucleoplasm|cytosol|attachment of spindle microtubules to kinetochore|negative regulation of phosphatase activity|nuclear body|CENP-A containing nucleosome assembly|protein localization to kinetochore|cell division KNOP1 460.1046284 537.9266632 382.2825936 0.710659314 -0.492769989 0.237977696 1 3.768721511 2.793646357 400506 lysine rich nucleolar protein 1 "GO:0003723,GO:0005515,GO:0005730" RNA binding|protein binding|nucleolus KNSTRN 978.6976399 898.236032 1059.159248 1.17915471 0.237753018 0.502197884 1 22.37702225 27.52257181 90417 kinetochore localized astrin (SPAG5) binding protein "GO:0000070,GO:0000226,GO:0000776,GO:0000777,GO:0000922,GO:0001726,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0007051,GO:0007059,GO:0016477,GO:0034451,GO:0035371,GO:0042803,GO:0051010,GO:0051301,GO:0051988,GO:0071364,GO:0072686" mitotic sister chromatid segregation|microtubule cytoskeleton organization|kinetochore|condensed chromosome kinetochore|spindle pole|ruffle|protein binding|nucleus|cytoplasm|plasma membrane|spindle organization|chromosome segregation|cell migration|centriolar satellite|microtubule plus-end|protein homodimerization activity|microtubule plus-end binding|cell division|regulation of attachment of spindle microtubules to kinetochore|cellular response to epidermal growth factor stimulus|mitotic spindle KNTC1 2012.250407 1505.179701 2519.321113 1.673767665 0.743099282 0.021545151 0.638999935 10.13723962 17.69826996 9735 kinetochore associated 1 "GO:0000777,GO:0000922,GO:0005515,GO:0005634,GO:0005828,GO:0005829,GO:0005886,GO:0007094,GO:0007096,GO:0015629,GO:0051301,GO:0065003,GO:1990423" condensed chromosome kinetochore|spindle pole|protein binding|nucleus|kinetochore microtubule|cytosol|plasma membrane|mitotic spindle assembly checkpoint|regulation of exit from mitosis|actin cytoskeleton|cell division|protein-containing complex assembly|RZZ complex KPNA1 2231.770885 2232.90313 2230.638639 0.998985853 -0.001463847 0.997957432 1 12.97185895 13.51691198 3836 karyopherin subunit alpha 1 "GO:0000018,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006309,GO:0006607,GO:0008139,GO:0014069,GO:0014841,GO:0014901,GO:0019054,GO:0030425,GO:0042981,GO:0043657,GO:0060828,GO:0061608,GO:0075733,GO:0098978,GO:0099527" regulation of DNA recombination|protein binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|cytosol|apoptotic DNA fragmentation|NLS-bearing protein import into nucleus|nuclear localization sequence binding|postsynaptic density|skeletal muscle satellite cell proliferation|satellite cell activation involved in skeletal muscle regeneration|modulation by virus of host cellular process|dendrite|regulation of apoptotic process|host cell|regulation of canonical Wnt signaling pathway|nuclear import signal receptor activity|intracellular transport of virus|glutamatergic synapse|postsynapse to nucleus signaling pathway "hsa05132,hsa05164" Salmonella infection|Influenza A KPNA2 7162.709526 7331.02696 6994.392093 0.954080804 -0.067816638 0.836504841 1 144.246563 143.5511121 3838 karyopherin subunit alpha 2 "GO:0000018,GO:0000139,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0006259,GO:0006607,GO:0008139,GO:0016020,GO:0019054,GO:0042826,GO:0043657,GO:0061608,GO:0075506,GO:0098892,GO:0098978,GO:0099527,GO:1903902" regulation of DNA recombination|Golgi membrane|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|DNA metabolic process|NLS-bearing protein import into nucleus|nuclear localization sequence binding|membrane|modulation by virus of host cellular process|histone deacetylase binding|host cell|nuclear import signal receptor activity|entry of viral genome into host nucleus through nuclear pore complex via importin|extrinsic component of postsynaptic specialization membrane|glutamatergic synapse|postsynapse to nucleus signaling pathway|positive regulation of viral life cycle hsa05164 Influenza A KPNA3 1213.256389 1374.250381 1052.262397 0.765699185 -0.385150373 0.259470214 1 15.81120712 12.62813286 3839 karyopherin subunit alpha 3 "GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005829,GO:0006607,GO:0008022,GO:0008139,GO:0019054,GO:0043657,GO:0046718,GO:0061608,GO:0065003,GO:0075732" protein binding|nucleus|nuclear pore|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|protein C-terminus binding|nuclear localization sequence binding|modulation by virus of host cellular process|host cell|viral entry into host cell|nuclear import signal receptor activity|protein-containing complex assembly|viral penetration into host nucleus hsa05132 Salmonella infection KPNA4 1864.774981 1863.459158 1866.090805 1.001412238 0.002035991 0.996882502 1 10.54263097 11.0122948 3840 karyopherin subunit alpha 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006607,GO:0008139,GO:0019054,GO:0031965,GO:0061608" protein binding|nucleus|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|nuclear localization sequence binding|modulation by virus of host cellular process|nuclear membrane|nuclear import signal receptor activity hsa05132 Salmonella infection KPNA5 74.904344 69.01700585 80.79168216 1.170605435 0.227254882 0.773864394 1 0.5918503 0.72266719 3841 karyopherin subunit alpha 5 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006607,GO:0008139,GO:0019054,GO:0061608" protein binding|nucleus|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|nuclear localization sequence binding|modulation by virus of host cellular process|nuclear import signal receptor activity hsa05164 Influenza A KPNA6 2096.444247 2074.569999 2118.318496 1.021087983 0.030107182 0.926822494 1 12.38152861 13.18722331 23633 karyopherin subunit alpha 6 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006607,GO:0008139,GO:0016020,GO:0019079,GO:0030682,GO:0043657,GO:0045944,GO:0060135,GO:0061608,GO:0075506,GO:1900017,GO:1903902" protein binding|nucleus|nucleoplasm|cytoplasm|NLS-bearing protein import into nucleus|nuclear localization sequence binding|membrane|viral genome replication|mitigation of host defenses by symbiont|host cell|positive regulation of transcription by RNA polymerase II|maternal process involved in female pregnancy|nuclear import signal receptor activity|entry of viral genome into host nucleus through nuclear pore complex via importin|positive regulation of cytokine production involved in inflammatory response|positive regulation of viral life cycle hsa05164 Influenza A KPNA7 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.065885592 0 402569 karyopherin subunit alpha 7 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006607,GO:0008139,GO:0019054,GO:0061608" protein binding|nucleus|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|nuclear localization sequence binding|modulation by virus of host cellular process|nuclear import signal receptor activity hsa05164 Influenza A KPNB1 12622.5288 12212.96517 13032.09244 1.067070303 0.09365523 0.785448154 1 97.10260612 108.0786345 3837 karyopherin subunit beta 1 "GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006309,GO:0006606,GO:0006607,GO:0006610,GO:0007079,GO:0007080,GO:0008139,GO:0008270,GO:0010494,GO:0016020,GO:0019054,GO:0019899,GO:0019904,GO:0030953,GO:0031291,GO:0031965,GO:0035580,GO:0040001,GO:0043312,GO:0043657,GO:0045184,GO:0045540,GO:0061608,GO:0070062,GO:0071782,GO:0075733,GO:0090307,GO:1904813" RNA binding|protein binding|extracellular region|nucleus|nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|cytosol|apoptotic DNA fragmentation|protein import into nucleus|NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|mitotic chromosome movement towards spindle pole|mitotic metaphase plate congression|nuclear localization sequence binding|zinc ion binding|cytoplasmic stress granule|membrane|modulation by virus of host cellular process|enzyme binding|protein domain specific binding|astral microtubule organization|Ran protein signal transduction|nuclear membrane|specific granule lumen|establishment of mitotic spindle localization|neutrophil degranulation|host cell|establishment of protein localization|regulation of cholesterol biosynthetic process|nuclear import signal receptor activity|extracellular exosome|endoplasmic reticulum tubular network|intracellular transport of virus|mitotic spindle assembly|ficolin-1-rich granule lumen hsa03013 RNA transport KPTN 206.9634267 206.0360616 207.8907919 1.009001969 0.01292899 0.990953226 1 3.939222223 4.145896203 11133 "kaptin, actin binding protein" "GO:0005765,GO:0007015,GO:0030027,GO:0031941,GO:0032420,GO:0034198,GO:0042149,GO:0051015,GO:0061462,GO:0098871,GO:0140007,GO:1904262" lysosomal membrane|actin filament organization|lamellipodium|filamentous actin|stereocilium|cellular response to amino acid starvation|cellular response to glucose starvation|actin filament binding|protein localization to lysosome|postsynaptic actin cytoskeleton|KICSTOR complex|negative regulation of TORC1 signaling KRAS 1756.174693 1646.258581 1866.090805 1.133534444 0.18082823 0.579430851 1 15.35491519 18.15507607 3845 "KRAS proto-oncogene, GTPase" "GO:0000165,GO:0001889,GO:0001934,GO:0002223,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005925,GO:0007265,GO:0007565,GO:0008284,GO:0008542,GO:0010628,GO:0016020,GO:0019002,GO:0019003,GO:0019221,GO:0021897,GO:0030036,GO:0030275,GO:0031234,GO:0031647,GO:0032228,GO:0035022,GO:0035900,GO:0038002,GO:0043406,GO:0043524,GO:0044877,GO:0045121,GO:0045596,GO:0048169,GO:0048873,GO:0051000,GO:0051092,GO:0051146,GO:0051384,GO:0051385,GO:0060441,GO:2000774" "MAPK cascade|liver development|positive regulation of protein phosphorylation|stimulatory C-type lectin receptor signaling pathway|GTPase activity|protein binding|GTP binding|cytoplasm|mitochondrion|cytosol|plasma membrane|focal adhesion|Ras protein signal transduction|female pregnancy|positive regulation of cell population proliferation|visual learning|positive regulation of gene expression|membrane|GMP binding|GDP binding|cytokine-mediated signaling pathway|forebrain astrocyte development|actin cytoskeleton organization|LRR domain binding|extrinsic component of cytoplasmic side of plasma membrane|regulation of protein stability|regulation of synaptic transmission, GABAergic|positive regulation of Rac protein signal transduction|response to isolation stress|endocrine signaling|positive regulation of MAP kinase activity|negative regulation of neuron apoptotic process|protein-containing complex binding|membrane raft|negative regulation of cell differentiation|regulation of long-term neuronal synaptic plasticity|homeostasis of number of cells within a tissue|positive regulation of nitric-oxide synthase activity|positive regulation of NF-kappaB transcription factor activity|striated muscle cell differentiation|response to glucocorticoid|response to mineralocorticoid|epithelial tube branching involved in lung morphogenesis|positive regulation of cellular senescence" "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04062,hsa04068,hsa04071,hsa04072,hsa04137,hsa04140,hsa04150,hsa04151,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04371,hsa04540,hsa04550,hsa04625,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04929,hsa04933,hsa04935,hsa04960,hsa05010,hsa05022,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" KRBA1 225.3392762 216.1856213 234.4929311 1.084683291 0.117273862 0.82832463 1 2.63451373 2.980707402 84626 KRAB-A domain containing 1 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process KRBA2 147.5385221 151.2284393 143.8486048 0.95120075 -0.072178243 0.914962895 1 0.607775508 0.603019434 124751 KRAB-A domain containing 2 "GO:0003676,GO:0005515,GO:0006355,GO:0015074" "nucleic acid binding|protein binding|regulation of transcription, DNA-templated|DNA integration" KRBOX4 337.3192046 361.3243247 313.3140845 0.867127019 -0.205684757 0.655383732 1 7.744309087 7.004567524 55634 KRAB box domain containing 4 GO:0006355 "regulation of transcription, DNA-templated" KRCC1 49.34957388 39.58328277 59.11586499 1.493455339 0.578654095 0.504064597 1 0.941198888 1.46618771 51315 lysine rich coiled-coil 1 GO:0005515 protein binding KREMEN1 484.14117 328.8457338 639.4366063 1.944488071 0.959390384 0.020547241 0.616714654 1.749094341 3.547598377 83999 kringle containing transmembrane protein 1 "GO:0005515,GO:0005886,GO:0006915,GO:0007154,GO:0016020,GO:0016021,GO:0016055,GO:0030279,GO:0043025,GO:0048681,GO:0060173,GO:0060828,GO:0090090" protein binding|plasma membrane|apoptotic process|cell communication|membrane|integral component of membrane|Wnt signaling pathway|negative regulation of ossification|neuronal cell body|negative regulation of axon regeneration|limb development|regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway KREMEN2 62.28890167 82.21143344 42.36636991 0.515334281 -0.956419529 0.228305008 1 2.087077233 1.121872451 79412 kringle containing transmembrane protein 2 "GO:0005886,GO:0016021,GO:0016055,GO:0030279,GO:0031901,GO:0060173,GO:0090090" plasma membrane|integral component of membrane|Wnt signaling pathway|negative regulation of ossification|early endosome membrane|limb development|negative regulation of canonical Wnt signaling pathway KRI1 677.6266156 691.1850145 664.0682168 0.960767671 -0.057740488 0.882983264 1 11.71163688 11.7368596 65095 KRI1 homolog "GO:0000447,GO:0003723,GO:0005730,GO:0030686" "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleolus|90S preribosome" KRIT1 748.1418071 763.2468882 733.0367259 0.960418886 -0.058264322 0.879013569 1 7.621404242 7.635045307 889 KRIT1 ankyrin repeat containing "GO:0001525,GO:0001937,GO:0005515,GO:0005546,GO:0005615,GO:0005737,GO:0005856,GO:0005886,GO:0005911,GO:0007264,GO:0008017,GO:0010596,GO:0016525,GO:0030695,GO:0045454,GO:0050790,GO:2000114,GO:2000352" "angiogenesis|negative regulation of endothelial cell proliferation|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular space|cytoplasm|cytoskeleton|plasma membrane|cell-cell junction|small GTPase mediated signal transduction|microtubule binding|negative regulation of endothelial cell migration|negative regulation of angiogenesis|GTPase regulator activity|cell redox homeostasis|regulation of catalytic activity|regulation of establishment of cell polarity|negative regulation of endothelial cell apoptotic process" hsa04015 Rap1 signaling pathway KRR1 1292.216598 1316.397891 1268.035304 0.963261422 -0.054000707 0.875245549 1 6.598466865 6.629841369 11103 KRR1 small subunit processome component homolog "GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0006364,GO:0016020,GO:0032040,GO:0045171" RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|cytoplasm|rRNA processing|membrane|small-subunit processome|intercellular bridge KRT10 282.5385523 287.232539 277.8445655 0.967315773 -0.047941172 0.928304092 1 6.725526957 6.785947834 3858 keratin 10 "GO:0001533,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005882,GO:0009986,GO:0016020,GO:0018149,GO:0030216,GO:0030280,GO:0031424,GO:0045684,GO:0046982,GO:0051290,GO:0070062,GO:0070268" cornified envelope|protein binding|extracellular space|nucleus|cytoplasm|cytosol|intermediate filament|cell surface|membrane|peptide cross-linking|keratinocyte differentiation|structural constituent of skin epidermis|keratinization|positive regulation of epidermis development|protein heterodimerization activity|protein heterotetramerization|extracellular exosome|cornification "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT15 8.060264643 12.17947162 3.941057666 0.32358199 -1.627796782 0.302513 1 0.30950691 0.104464955 3866 keratin 15 "GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005882,GO:0007010,GO:0008544,GO:0031424,GO:0070062,GO:0070268,GO:0097110" structural constituent of cytoskeleton|protein binding|nucleus|cytosol|intermediate filament|cytoskeleton organization|epidermis development|keratinization|extracellular exosome|cornification|scaffold protein binding "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT17 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.10165578 0.205865512 3872 keratin 17 "GO:0005198,GO:0005515,GO:0005829,GO:0005882,GO:0030307,GO:0031069,GO:0031424,GO:0045109,GO:0045111,GO:0045727,GO:0051798,GO:0070268,GO:0071944" structural molecule activity|protein binding|cytosol|intermediate filament|positive regulation of cell growth|hair follicle morphogenesis|keratinization|intermediate filament organization|intermediate filament cytoskeleton|positive regulation of translation|positive regulation of hair follicle development|cornification|cell periphery "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT18 6907.03514 6758.591793 7055.478487 1.043927301 0.062021246 0.84999999 1 228.656534 248.9830607 3875 keratin 18 "GO:0003723,GO:0005198,GO:0005515,GO:0005730,GO:0005737,GO:0005815,GO:0005829,GO:0005882,GO:0005912,GO:0007049,GO:0009653,GO:0009750,GO:0009897,GO:0016032,GO:0031424,GO:0031667,GO:0032991,GO:0033209,GO:0034451,GO:0043000,GO:0043066,GO:0045095,GO:0045104,GO:0048471,GO:0070062,GO:0070268,GO:0070365,GO:0072497,GO:0097110,GO:0097191,GO:0097284,GO:0098609,GO:0098641,GO:1902488" RNA binding|structural molecule activity|protein binding|nucleolus|cytoplasm|microtubule organizing center|cytosol|intermediate filament|adherens junction|cell cycle|anatomical structure morphogenesis|response to fructose|external side of plasma membrane|viral process|keratinization|response to nutrient levels|protein-containing complex|tumor necrosis factor-mediated signaling pathway|centriolar satellite|Golgi to plasma membrane CFTR protein transport|negative regulation of apoptotic process|keratin filament|intermediate filament cytoskeleton organization|perinuclear region of cytoplasm|extracellular exosome|cornification|hepatocyte differentiation|mesenchymal stem cell differentiation|scaffold protein binding|extrinsic apoptotic signaling pathway|hepatocyte apoptotic process|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|cholangiocyte apoptotic process "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT19 7.030462899 9.134603715 4.926322083 0.539303317 -0.890831188 0.625563046 1 0.332831261 0.187229006 3880 keratin 19 "GO:0005200,GO:0005515,GO:0005829,GO:0005882,GO:0005886,GO:0007219,GO:0008307,GO:0016010,GO:0016032,GO:0016327,GO:0030018,GO:0031424,GO:0042383,GO:0043034,GO:0043627,GO:0044877,GO:0045214,GO:0060706,GO:0070062,GO:0070268,GO:0071944,GO:1990357" structural constituent of cytoskeleton|protein binding|cytosol|intermediate filament|plasma membrane|Notch signaling pathway|structural constituent of muscle|dystrophin-associated glycoprotein complex|viral process|apicolateral plasma membrane|Z disc|keratinization|sarcolemma|costamere|response to estrogen|protein-containing complex binding|sarcomere organization|cell differentiation involved in embryonic placenta development|extracellular exosome|cornification|cell periphery|terminal web "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT222 97.07007177 102.5105528 91.62959074 0.893855201 -0.161886953 0.825668881 1 1.920753927 1.790831937 125113 keratin 222 "GO:0005198,GO:0005515,GO:0005882" structural molecule activity|protein binding|intermediate filament KRT23 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.062764273 0 25984 keratin 23 "GO:0005198,GO:0005515,GO:0005829,GO:0005882,GO:0031424,GO:0070268" structural molecule activity|protein binding|cytosol|intermediate filament|keratinization|cornification "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT27 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.094724704 0.095914614 342574 keratin 27 "GO:0003674,GO:0005198,GO:0005515,GO:0005829,GO:0005882,GO:0008150,GO:0031069,GO:0031424,GO:0070062,GO:0070268" molecular_function|structural molecule activity|protein binding|cytosol|intermediate filament|biological_process|hair follicle morphogenesis|keratinization|extracellular exosome|cornification "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT34 7.448866228 4.059823873 10.83790858 2.669551419 1.416597337 0.391522599 1 0.111023627 0.30915027 3885 keratin 34 "GO:0005198,GO:0005515,GO:0005615,GO:0005829,GO:0005882,GO:0008544,GO:0031424,GO:0070268" structural molecule activity|protein binding|extracellular space|cytosol|intermediate filament|epidermis development|keratinization|cornification "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT7 9645.972494 9614.677888 9677.267099 1.006509756 0.009361157 0.978070147 1 182.7888575 191.9038277 3855 keratin 7 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005882,GO:0016032,GO:0031424,GO:0045095,GO:0070062,GO:0070268" protein binding|nucleus|cytoplasm|cytosol|intermediate filament|viral process|keratinization|keratin filament|extracellular exosome|cornification KRT8 7309.969938 7597.960379 7021.979497 0.924192697 -0.113734405 0.729335909 1 193.5663427 186.598568 3856 keratin 8 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005882,GO:0005911,GO:0016010,GO:0016032,GO:0016327,GO:0016363,GO:0030018,GO:0031424,GO:0033209,GO:0042383,GO:0043034,GO:0044877,GO:0045095,GO:0045111,GO:0045214,GO:0051599,GO:0051707,GO:0060706,GO:0070062,GO:0070268,GO:0097110,GO:0097191,GO:0097284" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|intermediate filament|cell-cell junction|dystrophin-associated glycoprotein complex|viral process|apicolateral plasma membrane|nuclear matrix|Z disc|keratinization|tumor necrosis factor-mediated signaling pathway|sarcolemma|costamere|protein-containing complex binding|keratin filament|intermediate filament cytoskeleton|sarcomere organization|response to hydrostatic pressure|response to other organism|cell differentiation involved in embryonic placenta development|extracellular exosome|cornification|scaffold protein binding|extrinsic apoptotic signaling pathway|hepatocyte apoptotic process KRT80 2931.630038 3972.53766 1890.722415 0.475948267 -1.071123326 0.000858459 0.082521678 46.08223047 22.87753199 144501 keratin 80 "GO:0005515,GO:0005829,GO:0031424,GO:0045095,GO:0045111,GO:0070268" protein binding|cytosol|keratinization|keratin filament|intermediate filament cytoskeleton|cornification KRT81 4716.238836 4935.730874 4496.746797 0.911059965 -0.134382081 0.675065308 1 129.589091 123.1491266 3887 keratin 81 "GO:0005515,GO:0005615,GO:0005829,GO:0031424,GO:0045095,GO:0070268" protein binding|extracellular space|cytosol|keratinization|keratin filament|cornification KRT86 55.37720498 81.19647747 29.5579325 0.364029739 -1.457871781 0.079176211 1 0.628026136 0.238468221 3892 keratin 86 "GO:0005515,GO:0005615,GO:0005829,GO:0031424,GO:0045095,GO:0070268" protein binding|extracellular space|cytosol|keratinization|keratin filament|cornification KRTAP2-3 9.075220612 14.20938356 3.941057666 0.277355992 -1.850189203 0.218517863 1 0.822463028 0.23794132 730755 keratin associated protein 2-3 "GO:0005515,GO:0005829,GO:0031424,GO:0045095" protein binding|cytosol|keratinization|keratin filament KRTAP2-4 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.204383496 85294 keratin associated protein 2-4 "GO:0005515,GO:0005829,GO:0031424,GO:0045095" protein binding|cytosol|keratinization|keratin filament KRTCAP2 1452.23695 1445.297299 1459.176601 1.009603077 0.013788213 0.969221837 1 139.9602476 147.3911127 200185 keratinocyte associated protein 2 "GO:0006487,GO:0008047,GO:0008250,GO:0016021,GO:0042543,GO:0050790" protein N-linked glycosylation|enzyme activator activity|oligosaccharyltransferase complex|integral component of membrane|protein N-linked glycosylation via arginine|regulation of catalytic activity KRTCAP3 6.015506931 7.104691779 4.926322083 0.693389979 -0.528261108 0.84291128 1 0.341716595 0.2471494 200634 keratinocyte associated protein 3 "GO:0005515,GO:0016021" protein binding|integral component of membrane KSR1 379.4858985 246.6343003 512.3374966 2.07731648 1.054721028 0.017349278 0.570800302 1.199112723 2.598236069 8844 kinase suppressor of ras 1 "GO:0000165,GO:0000185,GO:0004672,GO:0005078,GO:0005515,GO:0005524,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006468,GO:0007165,GO:0007265,GO:0008022,GO:0016020,GO:0019933,GO:0032587,GO:0032991,GO:0042127,GO:0043405,GO:0043410,GO:0046872,GO:0071889,GO:0106310,GO:0106311" MAPK cascade|activation of MAPKKK activity|protein kinase activity|MAP-kinase scaffold activity|protein binding|ATP binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein phosphorylation|signal transduction|Ras protein signal transduction|protein C-terminus binding|membrane|cAMP-mediated signaling|ruffle membrane|protein-containing complex|regulation of cell population proliferation|regulation of MAP kinase activity|positive regulation of MAPK cascade|metal ion binding|14-3-3 protein binding|protein serine kinase activity|protein threonine kinase activity "hsa04014,hsa04625,hsa05152" Ras signaling pathway|C-type lectin receptor signaling pathway|Tuberculosis KSR2 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.012965732 0.002625721 283455 kinase suppressor of ras 2 "GO:0004672,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0007265,GO:0019722,GO:0046872,GO:0106310,GO:0106311,GO:0120162" protein kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|signal transduction|Ras protein signal transduction|calcium-mediated signaling|metal ion binding|protein serine kinase activity|protein threonine kinase activity|positive regulation of cold-induced thermogenesis hsa04014 Ras signaling pathway KTI12 268.2697856 254.7539481 281.7856231 1.106108954 0.145493502 0.772201567 1 7.554091775 8.715576007 112970 KTI12 chromatin associated homolog "GO:0002098,GO:0005515,GO:0005524,GO:0006357,GO:0033588" tRNA wobble uridine modification|protein binding|ATP binding|regulation of transcription by RNA polymerase II|elongator holoenzyme complex KTN1 5119.055359 5026.061955 5212.048764 1.03700448 0.052422127 0.870956815 1 22.37232441 24.19957119 3895 kinectin 1 "GO:0003723,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0005887,GO:0007018,GO:0015031,GO:0016020,GO:0016021,GO:0019894,GO:0030176,GO:0043687,GO:0044267,GO:0045296" RNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral component of plasma membrane|microtubule-based movement|protein transport|membrane|integral component of membrane|kinesin binding|integral component of endoplasmic reticulum membrane|post-translational protein modification|cellular protein metabolic process|cadherin binding KXD1 1642.55208 1691.931599 1593.172562 0.941629415 -0.086768707 0.792740207 1 28.16908834 27.66742479 79036 KxDL motif containing 1 "GO:0005515,GO:0005765,GO:0016192,GO:0031083,GO:0032418,GO:0099078" protein binding|lysosomal membrane|vesicle-mediated transport|BLOC-1 complex|lysosome localization|BORC complex KYAT1 189.5134586 191.826678 187.2002391 0.975882193 -0.035221097 0.959203988 1 2.256758308 2.297197701 883 kynurenine aminotransferase 1 "GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006559,GO:0006569,GO:0006575,GO:0008483,GO:0008652,GO:0016212,GO:0030170,GO:0042803,GO:0047316,GO:0047804,GO:0070189,GO:0097053" protein binding|cytoplasm|mitochondrion|cytosol|L-phenylalanine catabolic process|tryptophan catabolic process|cellular modified amino acid metabolic process|transaminase activity|cellular amino acid biosynthetic process|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding|protein homodimerization activity|glutamine-phenylpyruvate transaminase activity|cysteine-S-conjugate beta-lyase activity|kynurenine metabolic process|L-kynurenine catabolic process "hsa00270,hsa00380,hsa00450,hsa05204" Cysteine and methionine metabolism|Tryptophan metabolism|Selenocompound metabolism|Chemical carcinogenesis KYAT3 481.2459977 501.3882484 461.1037469 0.919654077 -0.120836793 0.773339324 1 12.37502241 11.87097593 56267 kynurenine aminotransferase 3 "GO:0003723,GO:0005737,GO:0005739,GO:0006103,GO:0006520,GO:0009058,GO:0016212,GO:0030170,GO:0042803,GO:0047315,GO:0047804,GO:0070189,GO:0097052" RNA binding|cytoplasm|mitochondrion|2-oxoglutarate metabolic process|cellular amino acid metabolic process|biosynthetic process|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding|protein homodimerization activity|kynurenine-glyoxylate transaminase activity|cysteine-S-conjugate beta-lyase activity|kynurenine metabolic process|L-kynurenine metabolic process "hsa00270,hsa00380,hsa00450,hsa05204" Cysteine and methionine metabolism|Tryptophan metabolism|Selenocompound metabolism|Chemical carcinogenesis KYNU 243.7420956 261.8586398 225.6255514 0.861631113 -0.214857749 0.675366009 1 4.465392702 4.013256899 8942 kynureninase "GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006569,GO:0007568,GO:0009435,GO:0019441,GO:0019442,GO:0019805,GO:0030170,GO:0030429,GO:0034341,GO:0034354,GO:0034516,GO:0042803,GO:0043420,GO:0061981,GO:0097053" nucleoplasm|cytoplasm|mitochondrion|cytosol|tryptophan catabolic process|aging|NAD biosynthetic process|tryptophan catabolic process to kynurenine|tryptophan catabolic process to acetyl-CoA|quinolinate biosynthetic process|pyridoxal phosphate binding|kynureninase activity|response to interferon-gamma|'de novo' NAD biosynthetic process from tryptophan|response to vitamin B6|protein homodimerization activity|anthranilate metabolic process|3-hydroxykynureninase activity|L-kynurenine catabolic process hsa00380 Tryptophan metabolism L1CAM 8528.221927 8303.354777 8753.089077 1.054162963 0.076097911 0.819004854 1 80.71701094 88.75416744 3897 L1 cell adhesion molecule "GO:0005515,GO:0005886,GO:0005925,GO:0006935,GO:0007155,GO:0007156,GO:0007160,GO:0007399,GO:0007411,GO:0008046,GO:0009986,GO:0016021,GO:0016477,GO:0019904,GO:0030424,GO:0030425,GO:0031175,GO:0043025,GO:0044295,GO:0045773,GO:0050808,GO:0050900,GO:0061564,GO:0062023" protein binding|plasma membrane|focal adhesion|chemotaxis|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-matrix adhesion|nervous system development|axon guidance|axon guidance receptor activity|cell surface|integral component of membrane|cell migration|protein domain specific binding|axon|dendrite|neuron projection development|neuronal cell body|axonal growth cone|positive regulation of axon extension|synapse organization|leukocyte migration|axon development|collagen-containing extracellular matrix "hsa04360,hsa04514" Axon guidance|Cell adhesion molecules L2HGDH 372.4000118 368.4290165 376.3710071 1.021556366 0.030768809 0.951067899 1 2.610468655 2.781613254 79944 L-2-hydroxyglutarate dehydrogenase "GO:0003973,GO:0005739,GO:0005743,GO:0006103,GO:0016021,GO:0031305,GO:0044267,GO:0047545,GO:0055114" (S)-2-hydroxy-acid oxidase activity|mitochondrion|mitochondrial inner membrane|2-oxoglutarate metabolic process|integral component of membrane|integral component of mitochondrial inner membrane|cellular protein metabolic process|2-hydroxyglutarate dehydrogenase activity|oxidation-reduction process hsa00650 Butanoate metabolism L3HYPDH 205.052281 210.0958855 200.0086766 0.951987594 -0.070985322 0.903335358 1 2.319733033 2.303484136 112849 trans-L-3-hydroxyproline dehydratase "GO:0016836,GO:0018112,GO:0050346" hydro-lyase activity|proline racemase activity|trans-L-3-hydroxyproline dehydratase activity hsa00330 Arginine and proline metabolism L3MBTL1 236.028727 206.0360616 266.0213925 1.291139961 0.368645399 0.472537675 1 1.609097867 2.167063871 26013 L3MBTL histone methyl-lysine binding protein 1 "GO:0000785,GO:0000793,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005886,GO:0006325,GO:0007088,GO:0008270,GO:0030097,GO:0031491,GO:0031493,GO:0032093,GO:0035064,GO:0042393,GO:0042802,GO:0045652,GO:0045892,GO:0051726,GO:1901796" "chromatin|condensed chromosome|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|plasma membrane|chromatin organization|regulation of mitotic nuclear division|zinc ion binding|hemopoiesis|nucleosome binding|nucleosomal histone binding|SAM domain binding|methylated histone binding|histone binding|identical protein binding|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|regulation of cell cycle|regulation of signal transduction by p53 class mediator" L3MBTL2 811.4374999 947.9688745 674.9061253 0.711949668 -0.490152843 0.181059266 1 13.99337781 10.39172825 83746 L3MBTL histone methyl-lysine binding protein 2 "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0008270,GO:0035064,GO:0042393,GO:0045892,GO:0070317" "chromatin binding|protein binding|nucleus|nucleoplasm|chromatin organization|zinc ion binding|methylated histone binding|histone binding|negative regulation of transcription, DNA-templated|negative regulation of G0 to G1 transition" other L3MBTL3 320.5724311 327.8307778 313.3140845 0.955718943 -0.065341681 0.894319078 1 2.998099021 2.988767255 84456 L3MBTL histone methyl-lysine binding protein 3 "GO:0003674,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006325,GO:0008270,GO:0030225,GO:0030851,GO:0042393,GO:0042802,GO:0043249,GO:0045892" "molecular_function|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|chromatin organization|zinc ion binding|macrophage differentiation|granulocyte differentiation|histone binding|identical protein binding|erythrocyte maturation|negative regulation of transcription, DNA-templated" LACC1 119.4166705 114.6900244 124.1433165 1.08242471 0.11426668 0.870184618 1 1.105145574 1.247765911 144811 laccase domain containing 1 "GO:0002221,GO:0002367,GO:0004000,GO:0004731,GO:0005507,GO:0005515,GO:0005634,GO:0005777,GO:0005783,GO:0006954,GO:0016682,GO:0017061,GO:0030641,GO:0045087,GO:0047975,GO:0050727,GO:0055114,GO:0070431,GO:1900542" "pattern recognition receptor signaling pathway|cytokine production involved in immune response|adenosine deaminase activity|purine-nucleoside phosphorylase activity|copper ion binding|protein binding|nucleus|peroxisome|endoplasmic reticulum|inflammatory response|oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor|S-methyl-5-thioadenosine phosphorylase activity|regulation of cellular pH|innate immune response|guanosine phosphorylase activity|regulation of inflammatory response|oxidation-reduction process|nucleotide-binding oligomerization domain containing 2 signaling pathway|regulation of purine nucleotide metabolic process" LACTB 448.705302 465.8647895 431.5458144 0.926332756 -0.110397565 0.796906054 1 6.328972134 6.115277013 114294 lactamase beta "GO:0005739,GO:0005829,GO:0006508,GO:0006629,GO:0008233,GO:0019216,GO:0042802" mitochondrion|cytosol|proteolysis|lipid metabolic process|peptidase activity|regulation of lipid metabolic process|identical protein binding LACTB2 402.6138801 379.5935322 425.6342279 1.121289463 0.165158761 0.706366816 1 12.59834422 14.73489824 51110 lactamase beta 2 "GO:0003727,GO:0004521,GO:0005515,GO:0005759,GO:0008270,GO:0090502" "single-stranded RNA binding|endoribonuclease activity|protein binding|mitochondrial matrix|zinc ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" LAGE3 191.9590522 224.305269 159.6128355 0.711587544 -0.490886838 0.370063632 1 11.97078037 8.885190222 8270 L antigen family member 3 "GO:0000408,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008033,GO:0008150,GO:0016604,GO:0045944,GO:0070525" EKC/KEOPS complex|protein binding|nucleus|nucleoplasm|cytoplasm|tRNA processing|biological_process|nuclear body|positive regulation of transcription by RNA polymerase II|tRNA threonylcarbamoyladenosine metabolic process LAMA1 274.1746911 153.2583512 395.091031 2.577941286 1.366219406 0.005622873 0.289781047 0.805019169 2.164687321 284217 laminin subunit alpha 1 "GO:0002011,GO:0005102,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0005606,GO:0005608,GO:0005615,GO:0005911,GO:0006468,GO:0007155,GO:0007166,GO:0007411,GO:0008022,GO:0009887,GO:0009888,GO:0016020,GO:0030155,GO:0030198,GO:0030334,GO:0031012,GO:0043010,GO:0043208,GO:0045198,GO:0045995,GO:0048514,GO:0060441,GO:0060445,GO:0061304,GO:0062023" morphogenesis of an epithelial sheet|signaling receptor binding|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|laminin-1 complex|laminin-3 complex|extracellular space|cell-cell junction|protein phosphorylation|cell adhesion|cell surface receptor signaling pathway|axon guidance|protein C-terminus binding|animal organ morphogenesis|tissue development|membrane|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|extracellular matrix|camera-type eye development|glycosphingolipid binding|establishment of epithelial cell apical/basal polarity|regulation of embryonic development|blood vessel morphogenesis|epithelial tube branching involved in lung morphogenesis|branching involved in salivary gland morphogenesis|retinal blood vessel morphogenesis|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414,hsa05416" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis LAMA2 9.000991732 9.134603715 8.867379749 0.970745971 -0.042834281 1 1 0.029180992 0.029547557 3908 laminin subunit alpha 2 "GO:0005102,GO:0005198,GO:0005201,GO:0005576,GO:0005604,GO:0007155,GO:0007411,GO:0007517,GO:0009887,GO:0009888,GO:0014037,GO:0030155,GO:0030198,GO:0030334,GO:0031594,GO:0032224,GO:0035633,GO:0042383,GO:0043083,GO:0043197,GO:0045995,GO:0062023" "signaling receptor binding|structural molecule activity|extracellular matrix structural constituent|extracellular region|basement membrane|cell adhesion|axon guidance|muscle organ development|animal organ morphogenesis|tissue development|Schwann cell differentiation|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|neuromuscular junction|positive regulation of synaptic transmission, cholinergic|maintenance of blood-brain barrier|sarcolemma|synaptic cleft|dendritic spine|regulation of embryonic development|collagen-containing extracellular matrix" "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414,hsa05416" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis LAMA3 239.8037596 228.3650929 251.2424262 1.100178767 0.137737964 0.792762437 1 1.021360503 1.172082678 3909 laminin subunit alpha 3 "GO:0001738,GO:0005178,GO:0005198,GO:0005201,GO:0005576,GO:0005604,GO:0005610,GO:0005783,GO:0007229,GO:0007411,GO:0008544,GO:0009887,GO:0009888,GO:0016477,GO:0030155,GO:0030198,GO:0030334,GO:0031581,GO:0035987,GO:0045995,GO:0062023,GO:0070062,GO:0098609" morphogenesis of a polarized epithelium|integrin binding|structural molecule activity|extracellular matrix structural constituent|extracellular region|basement membrane|laminin-5 complex|endoplasmic reticulum|integrin-mediated signaling pathway|axon guidance|epidermis development|animal organ morphogenesis|tissue development|cell migration|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|hemidesmosome assembly|endodermal cell differentiation|regulation of embryonic development|collagen-containing extracellular matrix|extracellular exosome|cell-cell adhesion "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMA4 8.508359524 9.134603715 7.882115332 0.862885307 -0.212759283 0.973293498 1 0.061357487 0.055225107 3910 laminin subunit alpha 4 "GO:0005102,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0007155,GO:0030155,GO:0030198,GO:0030334,GO:0045995,GO:0062023,GO:0070062,GO:0120163" signaling receptor binding|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|cell adhesion|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|regulation of embryonic development|collagen-containing extracellular matrix|extracellular exosome|negative regulation of cold-induced thermogenesis "hsa04151,hsa04510,hsa04512,hsa05143,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|African trypanosomiasis|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMA5 10809.65069 13762.80293 7856.498458 0.570850175 -0.808815949 0.017605328 0.573612057 60.22962207 35.86313129 3911 laminin subunit alpha 5 "GO:0001658,GO:0001738,GO:0001755,GO:0001942,GO:0005178,GO:0005201,GO:0005576,GO:0005604,GO:0005610,GO:0005615,GO:0005634,GO:0007229,GO:0007411,GO:0007517,GO:0009887,GO:0009888,GO:0016331,GO:0016477,GO:0019221,GO:0030155,GO:0030198,GO:0030324,GO:0030334,GO:0031594,GO:0034446,GO:0042127,GO:0042475,GO:0043083,GO:0043259,GO:0043260,GO:0045995,GO:0060271,GO:0060445,GO:0062023,GO:0070062,GO:0072659,GO:0098609" branching involved in ureteric bud morphogenesis|morphogenesis of a polarized epithelium|neural crest cell migration|hair follicle development|integrin binding|extracellular matrix structural constituent|extracellular region|basement membrane|laminin-5 complex|extracellular space|nucleus|integrin-mediated signaling pathway|axon guidance|muscle organ development|animal organ morphogenesis|tissue development|morphogenesis of embryonic epithelium|cell migration|cytokine-mediated signaling pathway|regulation of cell adhesion|extracellular matrix organization|lung development|regulation of cell migration|neuromuscular junction|substrate adhesion-dependent cell spreading|regulation of cell population proliferation|odontogenesis of dentin-containing tooth|synaptic cleft|laminin-10 complex|laminin-11 complex|regulation of embryonic development|cilium assembly|branching involved in salivary gland morphogenesis|collagen-containing extracellular matrix|extracellular exosome|protein localization to plasma membrane|cell-cell adhesion "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMB1 5966.42136 5837.011774 6095.830945 1.04434104 0.062592915 0.847306896 1 45.46663405 49.52803281 3912 laminin subunit beta 1 "GO:0005178,GO:0005198,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0005606,GO:0005607,GO:0005615,GO:0005788,GO:0007155,GO:0009887,GO:0009888,GO:0016477,GO:0021812,GO:0030198,GO:0030335,GO:0031175,GO:0034446,GO:0035987,GO:0042476,GO:0043256,GO:0043257,GO:0043259,GO:0043687,GO:0044267,GO:0048471,GO:0050679,GO:0062023,GO:0070062,GO:0070831" integrin binding|structural molecule activity|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|laminin-1 complex|laminin-2 complex|extracellular space|endoplasmic reticulum lumen|cell adhesion|animal organ morphogenesis|tissue development|cell migration|neuronal-glial interaction involved in cerebral cortex radial glia guided migration|extracellular matrix organization|positive regulation of cell migration|neuron projection development|substrate adhesion-dependent cell spreading|endodermal cell differentiation|odontogenesis|laminin complex|laminin-8 complex|laminin-10 complex|post-translational protein modification|cellular protein metabolic process|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|collagen-containing extracellular matrix|extracellular exosome|basement membrane assembly "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMB2 6064.041463 4865.698912 7262.384014 1.49256749 0.577796168 0.075747464 1 43.17282494 67.21409797 3913 laminin subunit beta 2 "GO:0005178,GO:0005198,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0005608,GO:0005788,GO:0007411,GO:0007528,GO:0007601,GO:0009887,GO:0009888,GO:0014002,GO:0014044,GO:0016477,GO:0030198,GO:0031594,GO:0034446,GO:0043083,GO:0043256,GO:0043260,GO:0043687,GO:0044267,GO:0048677,GO:0060041,GO:0062023,GO:0070062,GO:0070831,GO:0072249,GO:0072274" integrin binding|structural molecule activity|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|laminin-3 complex|endoplasmic reticulum lumen|axon guidance|neuromuscular junction development|visual perception|animal organ morphogenesis|tissue development|astrocyte development|Schwann cell development|cell migration|extracellular matrix organization|neuromuscular junction|substrate adhesion-dependent cell spreading|synaptic cleft|laminin complex|laminin-11 complex|post-translational protein modification|cellular protein metabolic process|axon extension involved in regeneration|retina development in camera-type eye|collagen-containing extracellular matrix|extracellular exosome|basement membrane assembly|metanephric glomerular visceral epithelial cell development|metanephric glomerular basement membrane development "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMB3 14831.53568 14977.70523 14685.36613 0.980481717 -0.028437367 0.935405777 1 168.9460872 172.7840173 3914 laminin subunit beta 3 "GO:0005198,GO:0005201,GO:0005515,GO:0005576,GO:0008544,GO:0009887,GO:0009888,GO:0016477,GO:0030198,GO:0031581,GO:0034446,GO:0035987,GO:0043256,GO:0044877,GO:0062023,GO:0070831" structural molecule activity|extracellular matrix structural constituent|protein binding|extracellular region|epidermis development|animal organ morphogenesis|tissue development|cell migration|extracellular matrix organization|hemidesmosome assembly|substrate adhesion-dependent cell spreading|endodermal cell differentiation|laminin complex|protein-containing complex binding|collagen-containing extracellular matrix|basement membrane assembly "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMC1 8144.860051 9644.111611 6645.60849 0.689084569 -0.537247045 0.105319151 1 61.60174432 44.27733405 3915 laminin subunit gamma 1 "GO:0005201,GO:0005576,GO:0005604,GO:0005606,GO:0005615,GO:0005788,GO:0007155,GO:0007492,GO:0009887,GO:0009888,GO:0016477,GO:0022617,GO:0030023,GO:0030198,GO:0031581,GO:0034446,GO:0035633,GO:0043259,GO:0043260,GO:0043687,GO:0044267,GO:0050679,GO:0062023,GO:0065003,GO:0070062" extracellular matrix structural constituent|extracellular region|basement membrane|laminin-1 complex|extracellular space|endoplasmic reticulum lumen|cell adhesion|endoderm development|animal organ morphogenesis|tissue development|cell migration|extracellular matrix disassembly|extracellular matrix constituent conferring elasticity|extracellular matrix organization|hemidesmosome assembly|substrate adhesion-dependent cell spreading|maintenance of blood-brain barrier|laminin-10 complex|laminin-11 complex|post-translational protein modification|cellular protein metabolic process|positive regulation of epithelial cell proliferation|collagen-containing extracellular matrix|protein-containing complex assembly|extracellular exosome "hsa04151,hsa04510,hsa04512,hsa05020,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Prion disease|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMC2 3410.919614 5586.31765 1235.521578 0.221169231 -2.176777403 5.54E-11 9.39E-08 45.34817785 10.46165704 3918 laminin subunit gamma 2 "GO:0005102,GO:0005201,GO:0005576,GO:0005604,GO:0005607,GO:0005615,GO:0005938,GO:0007155,GO:0008045,GO:0008201,GO:0008284,GO:0008544,GO:0009887,GO:0009888,GO:0016020,GO:0016358,GO:0030198,GO:0030335,GO:0031581,GO:0048471,GO:0062023" signaling receptor binding|extracellular matrix structural constituent|extracellular region|basement membrane|laminin-2 complex|extracellular space|cell cortex|cell adhesion|motor neuron axon guidance|heparin binding|positive regulation of cell population proliferation|epidermis development|animal organ morphogenesis|tissue development|membrane|dendrite development|extracellular matrix organization|positive regulation of cell migration|hemidesmosome assembly|perinuclear region of cytoplasm|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMP1 6848.04423 7609.124895 6086.963565 0.799955796 -0.322007812 0.325051903 1 167.7003188 139.9316024 3916 lysosomal associated membrane protein 1 "GO:0000421,GO:0001618,GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005770,GO:0005771,GO:0005829,GO:0005886,GO:0005887,GO:0009897,GO:0010008,GO:0016020,GO:0019899,GO:0019904,GO:0030285,GO:0030425,GO:0031902,GO:0035577,GO:0042383,GO:0042470,GO:0043025,GO:0043312,GO:0043323,GO:0044194,GO:0044754,GO:0045954,GO:0046718,GO:0048102,GO:0048471,GO:0050821,GO:0061474,GO:0070062,GO:0072594,GO:0090160,GO:0097208,GO:0101003,GO:0140507,GO:1902513" autophagosome membrane|virus receptor activity|protein binding|cytoplasm|lysosome|lysosomal membrane|late endosome|multivesicular body|cytosol|plasma membrane|integral component of plasma membrane|external side of plasma membrane|endosome membrane|membrane|enzyme binding|protein domain specific binding|integral component of synaptic vesicle membrane|dendrite|late endosome membrane|azurophil granule membrane|sarcolemma|melanosome|neuronal cell body|neutrophil degranulation|positive regulation of natural killer cell degranulation|cytolytic granule|autolysosome|positive regulation of natural killer cell mediated cytotoxicity|viral entry into host cell|autophagic cell death|perinuclear region of cytoplasm|protein stabilization|phagolysosome membrane|extracellular exosome|establishment of protein localization to organelle|Golgi to lysosome transport|alveolar lamellar body|ficolin-1-rich granule membrane|granzyme-mediated programmed cell death signaling pathway|regulation of organelle transport along microtubule "hsa04140,hsa04142,hsa04145,hsa05152" Autophagy - animal|Lysosome|Phagosome|Tuberculosis LAMP2 3906.787702 4527.718575 3285.856829 0.7257202 -0.462514668 0.147000025 1 24.42617948 18.49016068 3920 lysosomal associated membrane protein 2 "GO:0002576,GO:0005515,GO:0005615,GO:0005764,GO:0005765,GO:0005770,GO:0005886,GO:0006605,GO:0009267,GO:0016020,GO:0017038,GO:0019899,GO:0019904,GO:0030670,GO:0031088,GO:0031647,GO:0031902,GO:0035577,GO:0043202,GO:0043312,GO:0044754,GO:0045121,GO:0046716,GO:0050821,GO:0061684,GO:0061740,GO:0070062,GO:0072594,GO:0097352,GO:0097637,GO:0098857,GO:0101003,GO:1905146,GO:1990836" platelet degranulation|protein binding|extracellular space|lysosome|lysosomal membrane|late endosome|plasma membrane|protein targeting|cellular response to starvation|membrane|protein import|enzyme binding|protein domain specific binding|phagocytic vesicle membrane|platelet dense granule membrane|regulation of protein stability|late endosome membrane|azurophil granule membrane|lysosomal lumen|neutrophil degranulation|autolysosome|membrane raft|muscle cell cellular homeostasis|protein stabilization|chaperone-mediated autophagy|protein targeting to lysosome involved in chaperone-mediated autophagy|extracellular exosome|establishment of protein localization to organelle|autophagosome maturation|integral component of autophagosome membrane|membrane microdomain|ficolin-1-rich granule membrane|lysosomal protein catabolic process|lysosomal matrix "hsa04140,hsa04142,hsa04145,hsa05152" Autophagy - animal|Lysosome|Phagosome|Tuberculosis LAMP3 191.3503754 182.6920743 200.0086766 1.094785733 0.13064854 0.819111647 1 1.549089078 1.768974005 27074 lysosomal associated membrane protein 3 "GO:0002250,GO:0005765,GO:0005769,GO:0005886,GO:0010506,GO:0010628,GO:0016021,GO:0031902,GO:0031982,GO:0035455,GO:0043154,GO:0043231,GO:0046718,GO:0048471,GO:0072594,GO:0097233,GO:1901799,GO:1903900" adaptive immune response|lysosomal membrane|early endosome|plasma membrane|regulation of autophagy|positive regulation of gene expression|integral component of membrane|late endosome membrane|vesicle|response to interferon-alpha|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|intracellular membrane-bounded organelle|viral entry into host cell|perinuclear region of cytoplasm|establishment of protein localization to organelle|alveolar lamellar body membrane|negative regulation of proteasomal protein catabolic process|regulation of viral life cycle hsa04142 Lysosome LAMTOR1 1689.628767 1778.202857 1601.054677 0.900377969 -0.151397338 0.644212491 1 82.69945047 77.66823097 55004 "late endosomal/lysosomal adaptor, MAPK and MTOR activator 1" "GO:0001558,GO:0001919,GO:0005085,GO:0005515,GO:0005764,GO:0005765,GO:0005886,GO:0007032,GO:0007040,GO:0007050,GO:0010872,GO:0010874,GO:0016197,GO:0016241,GO:0031902,GO:0032008,GO:0032418,GO:0034613,GO:0035577,GO:0035579,GO:0042632,GO:0043312,GO:0043410,GO:0045121,GO:0050790,GO:0051020,GO:0060090,GO:0060620,GO:0070062,GO:0071230,GO:0071986,GO:0101003" regulation of cell growth|regulation of receptor recycling|guanyl-nucleotide exchange factor activity|protein binding|lysosome|lysosomal membrane|plasma membrane|endosome organization|lysosome organization|cell cycle arrest|regulation of cholesterol esterification|regulation of cholesterol efflux|endosomal transport|regulation of macroautophagy|late endosome membrane|positive regulation of TOR signaling|lysosome localization|cellular protein localization|azurophil granule membrane|specific granule membrane|cholesterol homeostasis|neutrophil degranulation|positive regulation of MAPK cascade|membrane raft|regulation of catalytic activity|GTPase binding|molecular adaptor activity|regulation of cholesterol import|extracellular exosome|cellular response to amino acid stimulus|Ragulator complex|ficolin-1-rich granule membrane hsa04150 mTOR signaling pathway LAMTOR2 869.2563392 926.6547991 811.8578792 0.876116845 -0.190804804 0.598867771 1 75.57455158 69.06428808 28956 "late endosomal/lysosomal adaptor, MAPK and MTOR activator 2" "GO:0000165,GO:0000186,GO:0001558,GO:0005085,GO:0005515,GO:0005765,GO:0005770,GO:0005886,GO:0007050,GO:0010008,GO:0010761,GO:0016241,GO:0032008,GO:0034613,GO:0035579,GO:0043312,GO:0060090,GO:0070821,GO:0071230,GO:0071986,GO:0150116,GO:1902414" MAPK cascade|activation of MAPKK activity|regulation of cell growth|guanyl-nucleotide exchange factor activity|protein binding|lysosomal membrane|late endosome|plasma membrane|cell cycle arrest|endosome membrane|fibroblast migration|regulation of macroautophagy|positive regulation of TOR signaling|cellular protein localization|specific granule membrane|neutrophil degranulation|molecular adaptor activity|tertiary granule membrane|cellular response to amino acid stimulus|Ragulator complex|regulation of cell-substrate junction organization|protein localization to cell junction hsa04150 mTOR signaling pathway LAMTOR3 301.1613367 381.6234441 220.6992293 0.578316748 -0.790068211 0.094970034 1 4.535996517 2.736241415 8649 "late endosomal/lysosomal adaptor, MAPK and MTOR activator 3" "GO:0000165,GO:0000186,GO:0005085,GO:0005515,GO:0005765,GO:0005886,GO:0005925,GO:0007050,GO:0010008,GO:0016241,GO:0019209,GO:0032008,GO:0034613,GO:0035579,GO:0043312,GO:0060090,GO:0070062,GO:0070821,GO:0071230,GO:0071986,GO:1902414" MAPK cascade|activation of MAPKK activity|guanyl-nucleotide exchange factor activity|protein binding|lysosomal membrane|plasma membrane|focal adhesion|cell cycle arrest|endosome membrane|regulation of macroautophagy|kinase activator activity|positive regulation of TOR signaling|cellular protein localization|specific granule membrane|neutrophil degranulation|molecular adaptor activity|extracellular exosome|tertiary granule membrane|cellular response to amino acid stimulus|Ragulator complex|protein localization to cell junction "hsa04010,hsa04150" MAPK signaling pathway|mTOR signaling pathway LAMTOR4 592.5308962 565.3304744 619.731318 1.096228394 0.132548408 0.738219399 1 30.36266613 34.71817441 389541 "late endosomal/lysosomal adaptor, MAPK and MTOR activator 4" "GO:0005085,GO:0005515,GO:0005764,GO:0005765,GO:0007050,GO:0008361,GO:0016241,GO:0032008,GO:0043231,GO:0050790,GO:0060090,GO:0061462,GO:0071230,GO:0071986" guanyl-nucleotide exchange factor activity|protein binding|lysosome|lysosomal membrane|cell cycle arrest|regulation of cell size|regulation of macroautophagy|positive regulation of TOR signaling|intracellular membrane-bounded organelle|regulation of catalytic activity|molecular adaptor activity|protein localization to lysosome|cellular response to amino acid stimulus|Ragulator complex hsa04150 mTOR signaling pathway LAMTOR5 1575.973987 1484.880582 1667.067393 1.122694588 0.166965518 0.613177506 1 121.2967147 142.0452113 10542 "late endosomal/lysosomal adaptor, MAPK and MTOR activator 5" "GO:0005085,GO:0005515,GO:0005764,GO:0005765,GO:0005829,GO:0007050,GO:0008361,GO:0009615,GO:0010628,GO:0016241,GO:0019079,GO:0032008,GO:0032757,GO:0032991,GO:0043123,GO:0043154,GO:0051092,GO:0060090,GO:0061462,GO:0071230,GO:0071986,GO:1900182,GO:1904263,GO:1905636" guanyl-nucleotide exchange factor activity|protein binding|lysosome|lysosomal membrane|cytosol|cell cycle arrest|regulation of cell size|response to virus|positive regulation of gene expression|regulation of macroautophagy|viral genome replication|positive regulation of TOR signaling|positive regulation of interleukin-8 production|protein-containing complex|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of NF-kappaB transcription factor activity|molecular adaptor activity|protein localization to lysosome|cellular response to amino acid stimulus|Ragulator complex|positive regulation of protein localization to nucleus|positive regulation of TORC1 signaling|positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding hsa04150 mTOR signaling pathway LANCL1 1918.080705 1533.598468 2302.562941 1.501411868 0.586319792 0.070213495 1 16.31408364 25.54926782 10314 LanC like 1 "GO:0004364,GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0005975,GO:0007186,GO:0008270,GO:0017124,GO:0043295,GO:0043523,GO:0050750,GO:1903203" glutathione transferase activity|G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|G protein-coupled receptor signaling pathway|zinc ion binding|SH3 domain binding|glutathione binding|regulation of neuron apoptotic process|low-density lipoprotein particle receptor binding|regulation of oxidative stress-induced neuron death LANCL2 489.5168248 494.2835566 484.7500929 0.980712562 -0.028097738 0.950767838 1 5.614200138 5.743089155 55915 LanC like 2 "GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0005975,GO:0009789,GO:0010314,GO:0030864,GO:0032266,GO:0045892,GO:0070273" "protein binding|ATP binding|GTP binding|nucleus|nucleoplasm|cytosol|plasma membrane|carbohydrate metabolic process|positive regulation of abscisic acid-activated signaling pathway|phosphatidylinositol-5-phosphate binding|cortical actin cytoskeleton|phosphatidylinositol-3-phosphate binding|negative regulation of transcription, DNA-templated|phosphatidylinositol-4-phosphate binding" LAP3 798.4415106 867.787353 729.0956682 0.840177799 -0.251233431 0.495050137 1 19.89604711 17.4362839 51056 leucine aminopeptidase 3 "GO:0004177,GO:0005515,GO:0005634,GO:0005654,GO:0005802,GO:0005829,GO:0005925,GO:0006508,GO:0008235,GO:0030145,GO:0030496,GO:0070006,GO:0070062" aminopeptidase activity|protein binding|nucleus|nucleoplasm|trans-Golgi network|cytosol|focal adhesion|proteolysis|metalloexopeptidase activity|manganese ion binding|midbody|metalloaminopeptidase activity|extracellular exosome "hsa00330,hsa00480" Arginine and proline metabolism|Glutathione metabolism LAPTM4A 2622.5319 2610.466751 2634.59705 1.009243672 0.013274542 0.968075382 1 96.85782546 101.9639566 9741 lysosomal protein transmembrane 4 alpha "GO:0005515,GO:0005765,GO:0005794,GO:0016021,GO:0031902" protein binding|lysosomal membrane|Golgi apparatus|integral component of membrane|late endosome membrane hsa04142 Lysosome LAPTM4B 6171.796788 7214.307023 5129.286553 0.710988115 -0.492102651 0.13048101 1 149.6229321 110.9625509 55353 lysosomal protein transmembrane 4 beta "GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005886,GO:0007032,GO:0016021,GO:0019900,GO:0031625,GO:0031902,GO:0032509,GO:0032585,GO:0032911,GO:0042995,GO:0097001,GO:0097213,GO:0097487,GO:1902936,GO:1905166,GO:1905671" "protein binding|lysosome|lysosomal membrane|endosome|early endosome|plasma membrane|endosome organization|integral component of membrane|kinase binding|ubiquitin protein ligase binding|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body membrane|negative regulation of transforming growth factor beta1 production|cell projection|ceramide binding|regulation of lysosomal membrane permeability|multivesicular body, internal vesicle|phosphatidylinositol bisphosphate binding|negative regulation of lysosomal protein catabolic process|regulation of lysosome organization" hsa04142 Lysosome LAPTM5 323.7318598 577.509946 69.95377357 0.121129989 -3.045372004 1.56E-09 1.32E-06 13.43538881 1.697531522 7805 lysosomal protein transmembrane 5 "GO:0002357,GO:0002720,GO:0005515,GO:0005764,GO:0005765,GO:0005829,GO:0005887,GO:0006622,GO:0006886,GO:0006919,GO:0012502,GO:0030133,GO:0031398,GO:0031410,GO:0031625,GO:0032689,GO:0032703,GO:0032735,GO:0032991,GO:0043410,GO:0048471,GO:0050860,GO:0050868,GO:0050869,GO:0060907,GO:0090160,GO:0097214,GO:0140036,GO:0140311,GO:1901224,GO:1903265,GO:1904093,GO:2000060,GO:2000646" defense response to tumor cell|positive regulation of cytokine production involved in immune response|protein binding|lysosome|lysosomal membrane|cytosol|integral component of plasma membrane|protein targeting to lysosome|intracellular protein transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|induction of programmed cell death|transport vesicle|positive regulation of protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase binding|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|positive regulation of interleukin-12 production|protein-containing complex|positive regulation of MAPK cascade|perinuclear region of cytoplasm|negative regulation of T cell receptor signaling pathway|negative regulation of T cell activation|negative regulation of B cell activation|positive regulation of macrophage cytokine production|Golgi to lysosome transport|positive regulation of lysosomal membrane permeability|ubiquitin-dependent protein binding|protein sequestering activity|positive regulation of NIK/NF-kappaB signaling|positive regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of autophagic cell death|positive regulation of ubiquitin-dependent protein catabolic process|positive regulation of receptor catabolic process hsa04142 Lysosome LARGE1 209.2660058 161.377999 257.1540127 1.593488669 0.67218876 0.206232313 1 0.992739747 1.650062216 9215 LARGE xylosyl- and glucuronyltransferase 1 "GO:0000139,GO:0005794,GO:0006044,GO:0006486,GO:0006493,GO:0006688,GO:0008375,GO:0009101,GO:0015020,GO:0016757,GO:0030145,GO:0030173,GO:0035252,GO:0035269,GO:0042285,GO:0043403,GO:0046716,GO:0060538" "Golgi membrane|Golgi apparatus|N-acetylglucosamine metabolic process|protein glycosylation|protein O-linked glycosylation|glycosphingolipid biosynthetic process|acetylglucosaminyltransferase activity|glycoprotein biosynthetic process|glucuronosyltransferase activity|transferase activity, transferring glycosyl groups|manganese ion binding|integral component of Golgi membrane|UDP-xylosyltransferase activity|protein O-linked mannosylation|xylosyltransferase activity|skeletal muscle tissue regeneration|muscle cell cellular homeostasis|skeletal muscle organ development" hsa00515 Mannose type O-glycan biosynthesis LARP1 10438.96214 11254.84673 9623.077556 0.855016313 -0.225976149 0.503489112 1 70.41609417 62.80037868 23367 "La ribonucleoprotein 1, translational regulator" "GO:0000339,GO:0000340,GO:0003723,GO:0003730,GO:0005515,GO:0005737,GO:0005844,GO:0006413,GO:0008190,GO:0008283,GO:0008494,GO:0010494,GO:0010608,GO:0016020,GO:0016239,GO:0017148,GO:0031369,GO:0031929,GO:0031931,GO:0038202,GO:0042788,GO:0043024,GO:0045070,GO:0045296,GO:0045947,GO:0045948,GO:0048027,GO:0048255,GO:0072752,GO:1990928" RNA cap binding|RNA 7-methylguanosine cap binding|RNA binding|mRNA 3'-UTR binding|protein binding|cytoplasm|polysome|translational initiation|eukaryotic initiation factor 4E binding|cell population proliferation|translation activator activity|cytoplasmic stress granule|posttranscriptional regulation of gene expression|membrane|positive regulation of macroautophagy|negative regulation of translation|translation initiation factor binding|TOR signaling|TORC1 complex|TORC1 signaling|polysomal ribosome|ribosomal small subunit binding|positive regulation of viral genome replication|cadherin binding|negative regulation of translational initiation|positive regulation of translational initiation|mRNA 5'-UTR binding|mRNA stabilization|cellular response to rapamycin|response to amino acid starvation LARP1B 344.9989223 280.1278473 409.8699973 1.463153347 0.54908098 0.225715255 1 1.488249998 2.27133747 55132 La ribonucleoprotein 1B "GO:0003723,GO:0005515,GO:0005634" RNA binding|protein binding|nucleus LARP4 1660.00873 1807.63658 1512.380879 0.836662024 -0.257283142 0.432572572 1 13.06743017 11.40397285 113251 La ribonucleoprotein 4 "GO:0003723,GO:0003730,GO:0005515,GO:0005829,GO:0005844,GO:0006412,GO:0007010,GO:0008143,GO:0010494,GO:0010608,GO:0016020,GO:0022604,GO:0022627,GO:0045727" RNA binding|mRNA 3'-UTR binding|protein binding|cytosol|polysome|translation|cytoskeleton organization|poly(A) binding|cytoplasmic stress granule|posttranscriptional regulation of gene expression|membrane|regulation of cell morphogenesis|cytosolic small ribosomal subunit|positive regulation of translation LARP4B 2181.216081 2144.601961 2217.830202 1.034145376 0.048439008 0.881183786 1 8.182652074 8.826562679 23185 La ribonucleoprotein 4B "GO:0003723,GO:0003730,GO:0005515,GO:0005730,GO:0005829,GO:0010494,GO:0016020,GO:0042788,GO:0045727,GO:1905870" RNA binding|mRNA 3'-UTR binding|protein binding|nucleolus|cytosol|cytoplasmic stress granule|membrane|polysomal ribosome|positive regulation of translation|positive regulation of 3'-UTR-mediated mRNA stabilization LARP6 979.1551373 963.193214 995.1170607 1.033143762 0.047041019 0.896958878 1 9.356029602 10.08250102 55323 "La ribonucleoprotein 6, translational regulator" "GO:0005515,GO:0005634,GO:0005737,GO:0005844,GO:0006396,GO:0017022,GO:0032967,GO:0035613,GO:0045727,GO:0048027,GO:1902416,GO:1990825,GO:1990904" protein binding|nucleus|cytoplasm|polysome|RNA processing|myosin binding|positive regulation of collagen biosynthetic process|RNA stem-loop binding|positive regulation of translation|mRNA 5'-UTR binding|positive regulation of mRNA binding|sequence-specific mRNA binding|ribonucleoprotein complex LARP7 510.7027313 460.7900096 560.615453 1.216639774 0.282902074 0.487656002 1 7.19845417 9.13518157 51574 "La ribonucleoprotein 7, transcriptional regulator" "GO:0000122,GO:0000494,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006397,GO:0007283,GO:0008380,GO:0017070,GO:0030154,GO:0032897,GO:0034244,GO:0048024,GO:0097322,GO:0120259,GO:1904871,GO:1905382,GO:1990438,GO:1990904" "negative regulation of transcription by RNA polymerase II|box C/D RNA 3'-end processing|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|mRNA processing|spermatogenesis|RNA splicing|U6 snRNA binding|cell differentiation|negative regulation of viral transcription|negative regulation of transcription elongation from RNA polymerase II promoter|regulation of mRNA splicing, via spliceosome|7SK snRNA binding|7SK snRNP|positive regulation of protein localization to Cajal body|positive regulation of snRNA transcription by RNA polymerase II|U6 2'-O-snRNA methylation|ribonucleoprotein complex" other LARS1 2585.688159 2988.030371 2183.345947 0.730697375 -0.452654071 0.156005326 1 31.26073066 23.82608031 51520 leucyl-tRNA synthetase 1 "GO:0002161,GO:0004819,GO:0004823,GO:0005096,GO:0005515,GO:0005524,GO:0005737,GO:0005764,GO:0005783,GO:0005829,GO:0006418,GO:0006425,GO:0006429,GO:0008361,GO:0012505,GO:0016604,GO:0017101,GO:0032008,GO:0034198,GO:0043547,GO:0071230,GO:0071233,GO:0106074,GO:1904263,GO:1990253" aminoacyl-tRNA editing activity|glutamine-tRNA ligase activity|leucine-tRNA ligase activity|GTPase activator activity|protein binding|ATP binding|cytoplasm|lysosome|endoplasmic reticulum|cytosol|tRNA aminoacylation for protein translation|glutaminyl-tRNA aminoacylation|leucyl-tRNA aminoacylation|regulation of cell size|endomembrane system|nuclear body|aminoacyl-tRNA synthetase multienzyme complex|positive regulation of TOR signaling|cellular response to amino acid starvation|positive regulation of GTPase activity|cellular response to amino acid stimulus|cellular response to leucine|aminoacyl-tRNA metabolism involved in translational fidelity|positive regulation of TORC1 signaling|cellular response to leucine starvation hsa00970 Aminoacyl-tRNA biosynthesis LARS2 938.7565747 996.6867609 880.8263884 0.883754478 -0.178282474 0.618140277 1 8.863681886 8.170746155 23395 "leucyl-tRNA synthetase 2, mitochondrial" "GO:0002161,GO:0004823,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006429,GO:0032543,GO:0106074" aminoacyl-tRNA editing activity|leucine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|leucyl-tRNA aminoacylation|mitochondrial translation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis LAS1L 1348.626326 1367.145689 1330.106962 0.972907988 -0.039624725 0.908330027 1 15.80486331 16.03904269 81887 LAS1 like ribosome biogenesis factor "GO:0000460,GO:0000470,GO:0003723,GO:0004519,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0016020,GO:0030687,GO:0071339,GO:0090305,GO:0090730" "maturation of 5.8S rRNA|maturation of LSU-rRNA|RNA binding|endonuclease activity|protein binding|nucleoplasm|nucleolus|rRNA processing|membrane|preribosome, large subunit precursor|MLL1 complex|nucleic acid phosphodiester bond hydrolysis|Las1 complex" LASP1 8792.751323 9211.740369 8373.762276 0.909031512 -0.137597788 0.67949861 1 119.3202436 113.1381309 3927 LIM and SH3 protein 1 "GO:0005515,GO:0005737,GO:0005925,GO:0006811,GO:0015075,GO:0030864,GO:0034220,GO:0045296,GO:0046872,GO:0051015" protein binding|cytoplasm|focal adhesion|ion transport|ion transmembrane transporter activity|cortical actin cytoskeleton|ion transmembrane transport|cadherin binding|metal ion binding|actin filament binding LAT 26.49549721 26.38885518 26.60213925 1.008082354 0.011613503 1 1 0.744155023 0.782483809 27040 linker for activation of T cells "GO:0000165,GO:0001772,GO:0002250,GO:0005515,GO:0005794,GO:0005886,GO:0006954,GO:0006955,GO:0007229,GO:0007265,GO:0008180,GO:0016021,GO:0019722,GO:0019901,GO:0030159,GO:0035556,GO:0038095,GO:0042110,GO:0043303,GO:0045121,GO:0045860,GO:0050852,GO:0050863" MAPK cascade|immunological synapse|adaptive immune response|protein binding|Golgi apparatus|plasma membrane|inflammatory response|immune response|integrin-mediated signaling pathway|Ras protein signal transduction|COP9 signalosome|integral component of membrane|calcium-mediated signaling|protein kinase binding|signaling receptor complex adaptor activity|intracellular signal transduction|Fc-epsilon receptor signaling pathway|T cell activation|mast cell degranulation|membrane raft|positive regulation of protein kinase activity|T cell receptor signaling pathway|regulation of T cell activation "hsa04014,hsa04015,hsa04064,hsa04650,hsa04658,hsa04659,hsa04660,hsa04664,hsa04666,hsa05135,hsa05235" Ras signaling pathway|Rap1 signaling pathway|NF-kappa B signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Yersinia infection|PD-L1 expression and PD-1 checkpoint pathway in cancer LAT2 50.67629114 62.92727004 38.42531225 0.61063053 -0.711628373 0.403509857 1 1.702480894 1.084367994 7462 linker for activation of T cells family member 2 "GO:0002250,GO:0005515,GO:0005886,GO:0016021,GO:0019722,GO:0035556,GO:0038095,GO:0042113,GO:0042169,GO:0043303,GO:0045121,GO:0050853,GO:0070062" adaptive immune response|protein binding|plasma membrane|integral component of membrane|calcium-mediated signaling|intracellular signal transduction|Fc-epsilon receptor signaling pathway|B cell activation|SH2 domain binding|mast cell degranulation|membrane raft|B cell receptor signaling pathway|extracellular exosome LATS1 651.8343131 645.5119959 658.1566303 1.019588535 0.027987056 0.9460702 1 3.659380497 3.891781437 9113 large tumor suppressor kinase 1 "GO:0000082,GO:0000086,GO:0000287,GO:0000819,GO:0000922,GO:0001827,GO:0001828,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005815,GO:0005829,GO:0006468,GO:0009755,GO:0017015,GO:0018105,GO:0019901,GO:0030216,GO:0030331,GO:0030496,GO:0030833,GO:0033138,GO:0033146,GO:0034613,GO:0035329,GO:0035556,GO:0043065,GO:0043254,GO:0045736,GO:0046620,GO:0051220,GO:0051301,GO:0060644,GO:0090090,GO:0106310,GO:0106311,GO:1900181,GO:2000058" G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|magnesium ion binding|sister chromatid segregation|spindle pole|inner cell mass cell fate commitment|inner cell mass cellular morphogenesis|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|microtubule organizing center|cytosol|protein phosphorylation|hormone-mediated signaling pathway|regulation of transforming growth factor beta receptor signaling pathway|peptidyl-serine phosphorylation|protein kinase binding|keratinocyte differentiation|estrogen receptor binding|midbody|regulation of actin filament polymerization|positive regulation of peptidyl-serine phosphorylation|regulation of intracellular estrogen receptor signaling pathway|cellular protein localization|hippo signaling|intracellular signal transduction|positive regulation of apoptotic process|regulation of protein-containing complex assembly|negative regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of organ growth|cytoplasmic sequestering of protein|cell division|mammary gland epithelial cell differentiation|negative regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity|negative regulation of protein localization to nucleus|regulation of ubiquitin-dependent protein catabolic process "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species LATS2 795.2469472 683.0653667 907.4285276 1.328465139 0.40976037 0.265440315 1 6.186489827 8.572557274 26524 large tumor suppressor kinase 2 "GO:0000082,GO:0000922,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006468,GO:0009755,GO:0017015,GO:0018105,GO:0034451,GO:0035329,GO:0035556,GO:0043065,GO:0045736,GO:0046620,GO:0046872,GO:0051301,GO:0090090,GO:0106310,GO:0106311,GO:1900181" G1/S transition of mitotic cell cycle|spindle pole|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytosol|protein phosphorylation|hormone-mediated signaling pathway|regulation of transforming growth factor beta receptor signaling pathway|peptidyl-serine phosphorylation|centriolar satellite|hippo signaling|intracellular signal transduction|positive regulation of apoptotic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of organ growth|metal ion binding|cell division|negative regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity|negative regulation of protein localization to nucleus "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species LAYN 161.0798457 133.9741878 188.1855036 1.404640003 0.490200427 0.398727763 1 2.607732506 3.820709365 143903 layilin "GO:0001726,GO:0005540,GO:0005925,GO:0009986,GO:0016021,GO:0030246" ruffle|hyaluronic acid binding|focal adhesion|cell surface|integral component of membrane|carbohydrate binding LBH 15.37551889 7.104691779 23.646346 3.328271899 1.734773297 0.160913136 1 0.108316549 0.376036101 81606 LBH regulator of WNT signaling pathway "GO:0005515,GO:0005634,GO:0005737,GO:0007275,GO:0032991,GO:0043408,GO:0045892,GO:0045893" "protein binding|nucleus|cytoplasm|multicellular organism development|protein-containing complex|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated" LBHD1 95.87696649 88.30116925 103.4527637 1.171589964 0.228467741 0.750292146 1 2.416068457 2.952574116 79081 LBH domain containing 1 "GO:0005634,GO:0045893" "nucleus|positive regulation of transcription, DNA-templated" LBR 1556.197192 1446.312255 1666.082128 1.151951885 0.204080459 0.536893962 1 16.50532074 19.83235271 3930 lamin B receptor "GO:0003677,GO:0003723,GO:0005515,GO:0005521,GO:0005634,GO:0005635,GO:0005637,GO:0005639,GO:0005737,GO:0005789,GO:0006695,GO:0016020,GO:0016021,GO:0016126,GO:0016627,GO:0030223,GO:0031965,GO:0050613,GO:0055114,GO:0070087,GO:0070402" "DNA binding|RNA binding|protein binding|lamin binding|nucleus|nuclear envelope|nuclear inner membrane|integral component of nuclear inner membrane|cytoplasm|endoplasmic reticulum membrane|cholesterol biosynthetic process|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity, acting on the CH-CH group of donors|neutrophil differentiation|nuclear membrane|delta14-sterol reductase activity|oxidation-reduction process|chromo shadow domain binding|NADPH binding" hsa00100 Steroid biosynthesis LBX1 130.8686991 89.31612522 172.4212729 1.930460737 0.948945212 0.127009473 1 2.555676076 5.146153191 10660 ladybird homeobox 1 "GO:0000785,GO:0000981,GO:0001947,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007517,GO:0008285,GO:0009653,GO:0021522,GO:0045665,GO:0048664,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|heart looping|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|muscle organ development|negative regulation of cell population proliferation|anatomical structure morphogenesis|spinal cord motor neuron differentiation|negative regulation of neuron differentiation|neuron fate determination|sequence-specific double-stranded DNA binding" LBX2 109.3089265 130.9293199 87.68853307 0.669739468 -0.578328106 0.38151799 1 3.848582799 2.688578102 85474 ladybird homeobox 2 "GO:0000785,GO:0000981,GO:0005634,GO:0006357,GO:0042692,GO:1904105,GO:1990837,GO:2000052" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|muscle cell differentiation|positive regulation of convergent extension involved in gastrulation|sequence-specific double-stranded DNA binding|positive regulation of non-canonical Wnt signaling pathway" LCA5 158.9905507 125.8545401 192.1265612 1.526576325 0.610299722 0.294595979 1 1.36082162 2.16688395 167691 lebercilin LCA5 "GO:0005515,GO:0005929,GO:0005930,GO:0032391,GO:0036064,GO:0042073,GO:0044877,GO:0045494" protein binding|cilium|axoneme|photoreceptor connecting cilium|ciliary basal body|intraciliary transport|protein-containing complex binding|photoreceptor cell maintenance LCA5L 14.0609258 18.26920743 9.852644165 0.539303317 -0.890831188 0.491533239 1 0.178865437 0.100617946 150082 lebercilin LCA5 like "GO:0005515,GO:0005930,GO:0042073" protein binding|axoneme|intraciliary transport LCAT 68.1289809 43.64310664 92.61485516 2.122095843 1.085489816 0.15996596 1 1.477519644 3.27050026 3931 lecithin-cholesterol acyltransferase "GO:0003847,GO:0004607,GO:0004806,GO:0005515,GO:0005576,GO:0005615,GO:0006629,GO:0006644,GO:0006656,GO:0008203,GO:0030301,GO:0034186,GO:0034364,GO:0034372,GO:0034375,GO:0034435,GO:0042158,GO:0042632,GO:0043691,GO:0046470,GO:0047179,GO:0070062,GO:0090107" 1-alkyl-2-acetylglycerophosphocholine esterase activity|phosphatidylcholine-sterol O-acyltransferase activity|triglyceride lipase activity|protein binding|extracellular region|extracellular space|lipid metabolic process|phospholipid metabolic process|phosphatidylcholine biosynthetic process|cholesterol metabolic process|cholesterol transport|apolipoprotein A-I binding|high-density lipoprotein particle|very-low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|cholesterol esterification|lipoprotein biosynthetic process|cholesterol homeostasis|reverse cholesterol transport|phosphatidylcholine metabolic process|platelet-activating factor acetyltransferase activity|extracellular exosome|regulation of high-density lipoprotein particle assembly "hsa00564,hsa04979" Glycerophospholipid metabolism|Cholesterol metabolism LCLAT1 341.809556 398.8776956 284.7414164 0.713856452 -0.486294101 0.284662649 1 3.281635498 2.443527097 253558 lysocardiolipin acyltransferase 1 "GO:0003841,GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0006654,GO:0007275,GO:0008374,GO:0012505,GO:0016020,GO:0016021,GO:0016024,GO:0016746,GO:0035965,GO:0036149" "1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|phosphatidic acid biosynthetic process|multicellular organism development|O-acyltransferase activity|endomembrane system|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|transferase activity, transferring acyl groups|cardiolipin acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling" "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism LCMT1 500.4613754 467.8947014 533.0280494 1.139205141 0.188027562 0.647834186 1 15.2100231 18.0737279 51451 leucine carboxyl methyltransferase 1 "GO:0000086,GO:0003880,GO:0005515,GO:0005654,GO:0005829,GO:0006464,GO:0006479,GO:0006481,GO:0008757,GO:0010906,GO:0018423,GO:0031333,GO:0042981,GO:0090266" G2/M transition of mitotic cell cycle|protein C-terminal carboxyl O-methyltransferase activity|protein binding|nucleoplasm|cytosol|cellular protein modification process|protein methylation|C-terminal protein methylation|S-adenosylmethionine-dependent methyltransferase activity|regulation of glucose metabolic process|protein C-terminal leucine carboxyl O-methyltransferase activity|negative regulation of protein-containing complex assembly|regulation of apoptotic process|regulation of mitotic cell cycle spindle assembly checkpoint LCMT2 281.9419996 280.1278473 283.756152 1.012952317 0.018566263 0.977483163 1 2.048734618 2.164664714 9836 leucine carboxyl methyltransferase 2 "GO:0005515,GO:0005737,GO:0006400,GO:0008175,GO:0030488,GO:0031591" protein binding|cytoplasm|tRNA modification|tRNA methyltransferase activity|tRNA methylation|wybutosine biosynthetic process LCN10 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.077299157 0.052180114 414332 lipocalin 10 "GO:0005576,GO:0036094" extracellular region|small molecule binding LCN12 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.05726395 0 286256 lipocalin 12 "GO:0001972,GO:0005549,GO:0005576,GO:0005615,GO:0015909" retinoic acid binding|odorant binding|extracellular region|extracellular space|long-chain fatty acid transport LCN2 856.6391669 1512.284393 200.993941 0.132907502 -2.911505555 1.08E-13 2.45E-10 93.40471888 12.94894073 3934 lipocalin 2 "GO:0005506,GO:0005515,GO:0005549,GO:0005576,GO:0005615,GO:0006879,GO:0006915,GO:0015891,GO:0019221,GO:0019730,GO:0035580,GO:0036094,GO:0042742,GO:0042802,GO:0043312,GO:0045087,GO:0070062,GO:0097577,GO:0120162,GO:1903981" iron ion binding|protein binding|odorant binding|extracellular region|extracellular space|cellular iron ion homeostasis|apoptotic process|siderophore transport|cytokine-mediated signaling pathway|antimicrobial humoral response|specific granule lumen|small molecule binding|defense response to bacterium|identical protein binding|neutrophil degranulation|innate immune response|extracellular exosome|sequestering of iron ion|positive regulation of cold-induced thermogenesis|enterobactin binding hsa04657 IL-17 signaling pathway LCOR 2457.090118 2144.601961 2769.578275 1.291418326 0.368956405 0.247896953 1 4.233737035 5.703044423 84458 ligand dependent nuclear receptor corepressor "GO:0000122,GO:0001226,GO:0003677,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030331,GO:0042826,GO:0071392,GO:1990226,GO:1990381" negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|estrogen receptor binding|histone deacetylase binding|cellular response to estradiol stimulus|histone methyltransferase binding|ubiquitin-specific protease binding LCORL 300.2287744 284.1876711 316.2698777 1.112890916 0.154312189 0.749072436 1 0.876772843 1.017783994 254251 ligand dependent nuclear receptor corepressor like "GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:1990226" DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|histone methyltransferase binding LCP1 819.8553009 1152.98998 486.7206218 0.422137772 -1.244214169 0.000775017 0.079140395 15.60525788 6.871334546 3936 lymphocyte cytosolic protein 1 "GO:0001725,GO:0001726,GO:0001891,GO:0002102,GO:0002286,GO:0003779,GO:0005178,GO:0005509,GO:0005615,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005925,GO:0010737,GO:0015629,GO:0016477,GO:0022617,GO:0030054,GO:0030175,GO:0030866,GO:0031100,GO:0032432,GO:0032587,GO:0033157,GO:0035722,GO:0042802,GO:0044319,GO:0048471,GO:0051015,GO:0051017,GO:0051020,GO:0051639,GO:0051764,GO:0070062,GO:0071803" "stress fiber|ruffle|phagocytic cup|podosome|T cell activation involved in immune response|actin binding|integrin binding|calcium ion binding|extracellular space|cytoplasm|cytosol|actin filament|plasma membrane|focal adhesion|protein kinase A signaling|actin cytoskeleton|cell migration|extracellular matrix disassembly|cell junction|filopodium|cortical actin cytoskeleton organization|animal organ regeneration|actin filament bundle|ruffle membrane|regulation of intracellular protein transport|interleukin-12-mediated signaling pathway|identical protein binding|wound healing, spreading of cells|perinuclear region of cytoplasm|actin filament binding|actin filament bundle assembly|GTPase binding|actin filament network formation|actin crosslink formation|extracellular exosome|positive regulation of podosome assembly" LCTL 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.042435833 0.05729187 197021 lactase like "GO:0002089,GO:0005783,GO:0005789,GO:0005903,GO:0005975,GO:0007601,GO:0008422,GO:0016021,GO:0050896" lens morphogenesis in camera-type eye|endoplasmic reticulum|endoplasmic reticulum membrane|brush border|carbohydrate metabolic process|visual perception|beta-glucosidase activity|integral component of membrane|response to stimulus LDAH 463.0064818 466.8797455 459.1332181 0.983407874 -0.024138188 0.959411511 1 6.004523122 6.159254263 60526 lipid droplet associated hydrolase "GO:0005783,GO:0005811,GO:0016042,GO:0016298,GO:0019915" endoplasmic reticulum|lipid droplet|lipid catabolic process|lipase activity|lipid storage LDB1 3742.326233 3387.923022 4096.729444 1.209215622 0.274071522 0.389415931 1 46.06344945 58.10000045 8861 LIM domain binding 1 "GO:0000122,GO:0000785,GO:0000972,GO:0001102,GO:0001702,GO:0001942,GO:0003677,GO:0003682,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006355,GO:0006366,GO:0007275,GO:0007399,GO:0009948,GO:0010669,GO:0016055,GO:0019899,GO:0021702,GO:0022607,GO:0030182,GO:0030274,GO:0030334,GO:0031252,GO:0032991,GO:0034243,GO:0035019,GO:0042803,GO:0043549,GO:0043621,GO:0043973,GO:0045647,GO:0045785,GO:0045892,GO:0045944,GO:0046985,GO:0048382,GO:0051893,GO:0140297,GO:1902036,GO:1990907" "negative regulation of transcription by RNA polymerase II|chromatin|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|RNA polymerase II activating transcription factor binding|gastrulation with mouth forming second|hair follicle development|DNA binding|chromatin binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription, DNA-templated|transcription by RNA polymerase II|multicellular organism development|nervous system development|anterior/posterior axis specification|epithelial structure maintenance|Wnt signaling pathway|enzyme binding|cerebellar Purkinje cell differentiation|cellular component assembly|neuron differentiation|LIM domain binding|regulation of cell migration|cell leading edge|protein-containing complex|regulation of transcription elongation from RNA polymerase II promoter|somatic stem cell population maintenance|protein homodimerization activity|regulation of kinase activity|protein self-association|histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|positive regulation of cell adhesion|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of hemoglobin biosynthetic process|mesendoderm development|regulation of focal adhesion assembly|DNA-binding transcription factor binding|regulation of hematopoietic stem cell differentiation|beta-catenin-TCF complex" hsa05202 Transcriptional misregulation in cancer LDB3 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.039389992 0.03190784 11155 LIM domain binding 3 "GO:0001725,GO:0003779,GO:0005080,GO:0005515,GO:0005856,GO:0005912,GO:0007507,GO:0008092,GO:0030018,GO:0030036,GO:0031143,GO:0031941,GO:0045214,GO:0046872,GO:0048471,GO:0051371,GO:0061061" stress fiber|actin binding|protein kinase C binding|protein binding|cytoskeleton|adherens junction|heart development|cytoskeletal protein binding|Z disc|actin cytoskeleton organization|pseudopodium|filamentous actin|sarcomere organization|metal ion binding|perinuclear region of cytoplasm|muscle alpha-actinin binding|muscle structure development LDHA 33384.01403 46464.68423 20303.34383 0.436962914 -1.194417254 0.00297404 0.186620997 940.9325625 428.8634226 3939 lactate dehydrogenase A "GO:0001666,GO:0004459,GO:0005515,GO:0005634,GO:0005829,GO:0006089,GO:0006090,GO:0006096,GO:0007584,GO:0009749,GO:0016020,GO:0019674,GO:0019900,GO:0042493,GO:0042542,GO:0042802,GO:0043065,GO:0043627,GO:0045296,GO:0048569,GO:0051287,GO:0051591,GO:0055114,GO:0070062" response to hypoxia|L-lactate dehydrogenase activity|protein binding|nucleus|cytosol|lactate metabolic process|pyruvate metabolic process|glycolytic process|response to nutrient|response to glucose|membrane|NAD metabolic process|kinase binding|response to drug|response to hydrogen peroxide|identical protein binding|positive regulation of apoptotic process|response to estrogen|cadherin binding|post-embryonic animal organ development|NAD binding|response to cAMP|oxidation-reduction process|extracellular exosome "hsa00010,hsa00270,hsa00620,hsa00640,hsa04066,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Cysteine and methionine metabolism|Pyruvate metabolism|Propanoate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer LDHB 12197.71456 13144.69475 11250.73437 0.855914465 -0.224461465 0.512539135 1 340.5280906 304.017959 3945 lactate dehydrogenase B "GO:0004459,GO:0005515,GO:0005737,GO:0005829,GO:0005975,GO:0006090,GO:0016020,GO:0042802,GO:0045121,GO:0055114,GO:0070062" L-lactate dehydrogenase activity|protein binding|cytoplasm|cytosol|carbohydrate metabolic process|pyruvate metabolic process|membrane|identical protein binding|membrane raft|oxidation-reduction process|extracellular exosome "hsa00010,hsa00270,hsa00620,hsa00640,hsa04066,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Cysteine and methionine metabolism|Pyruvate metabolism|Propanoate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer LDHD 21.06169715 25.37389921 16.74949508 0.66010726 -0.59922763 0.604238768 1 0.561668917 0.386732641 197257 lactate dehydrogenase D "GO:0004458,GO:0005515,GO:0005739,GO:0005743,GO:0008720,GO:0050660,GO:0055114,GO:0071949,GO:1903457" D-lactate dehydrogenase (cytochrome) activity|protein binding|mitochondrion|mitochondrial inner membrane|D-lactate dehydrogenase activity|flavin adenine dinucleotide binding|oxidation-reduction process|FAD binding|lactate catabolic process hsa00620 Pyruvate metabolism LDLR 1865.35941 1836.055347 1894.663473 1.031920675 0.045332073 0.890263935 1 17.86889433 19.23357097 3949 low density lipoprotein receptor "GO:0001540,GO:0001618,GO:0002020,GO:0005041,GO:0005509,GO:0005515,GO:0005764,GO:0005769,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0005905,GO:0006629,GO:0006897,GO:0006898,GO:0006909,GO:0007616,GO:0008203,GO:0009897,GO:0009986,GO:0010008,GO:0010867,GO:0010899,GO:0015914,GO:0016020,GO:0016323,GO:0030169,GO:0030229,GO:0030299,GO:0030301,GO:0030669,GO:0032050,GO:0034362,GO:0034381,GO:0034382,GO:0034383,GO:0036020,GO:0042632,GO:0042802,GO:0043235,GO:0045177,GO:0046718,GO:0051246,GO:0051248,GO:0061024,GO:0061771,GO:0061889,GO:0070508,GO:0071404,GO:0090118,GO:0097242,GO:0150094,GO:1903979,GO:1905167,GO:1905907,GO:1990666" amyloid-beta binding|virus receptor activity|protease binding|low-density lipoprotein particle receptor activity|calcium ion binding|protein binding|lysosome|early endosome|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|clathrin-coated pit|lipid metabolic process|endocytosis|receptor-mediated endocytosis|phagocytosis|long-term memory|cholesterol metabolic process|external side of plasma membrane|cell surface|endosome membrane|positive regulation of triglyceride biosynthetic process|regulation of phosphatidylcholine catabolic process|phospholipid transport|membrane|basolateral plasma membrane|low-density lipoprotein particle binding|very-low-density lipoprotein particle receptor activity|intestinal cholesterol absorption|cholesterol transport|clathrin-coated endocytic vesicle membrane|clathrin heavy chain binding|low-density lipoprotein particle|plasma lipoprotein particle clearance|chylomicron remnant clearance|low-density lipoprotein particle clearance|endolysosome membrane|cholesterol homeostasis|identical protein binding|receptor complex|apical part of cell|viral entry into host cell|regulation of protein metabolic process|negative regulation of protein metabolic process|membrane organization|response to caloric restriction|negative regulation of astrocyte activation|cholesterol import|cellular response to low-density lipoprotein particle stimulus|receptor-mediated endocytosis involved in cholesterol transport|amyloid-beta clearance|amyloid-beta clearance by cellular catabolic process|negative regulation of microglial cell activation|positive regulation of lysosomal protein catabolic process|negative regulation of amyloid fibril formation|PCSK9-LDLR complex "hsa04144,hsa04913,hsa04925,hsa04927,hsa04934,hsa04976,hsa04979,hsa05145,hsa05160" Endocytosis|Ovarian steroidogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Bile secretion|Cholesterol metabolism|Toxoplasmosis|Hepatitis C LDLRAD3 620.0534735 628.2577444 611.8492027 0.973882468 -0.038180422 0.92584838 1 8.096447429 8.224641517 143458 low density lipoprotein receptor class A domain containing 3 "GO:0001540,GO:0005886,GO:0006898,GO:0016021,GO:0070613" amyloid-beta binding|plasma membrane|receptor-mediated endocytosis|integral component of membrane|regulation of protein processing LDLRAD4 38.95976018 36.53841486 41.38110549 1.132536966 0.17955814 0.870182553 1 0.090650623 0.107087581 753 low density lipoprotein receptor class A domain containing 4 "GO:0000139,GO:0010719,GO:0010991,GO:0016021,GO:0030336,GO:0030512,GO:0031901,GO:0043231,GO:0060394,GO:0070412" Golgi membrane|negative regulation of epithelial to mesenchymal transition|negative regulation of SMAD protein complex assembly|integral component of membrane|negative regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|early endosome membrane|intracellular membrane-bounded organelle|negative regulation of pathway-restricted SMAD protein phosphorylation|R-SMAD binding LDLRAP1 325.4326891 222.2753571 428.5900212 1.928194051 0.94725025 0.040821058 0.929896847 1.768373028 3.556645258 26119 low density lipoprotein receptor adaptor protein 1 "GO:0001540,GO:0001784,GO:0005515,GO:0005546,GO:0005769,GO:0005829,GO:0005883,GO:0005886,GO:0006898,GO:0008203,GO:0009898,GO:0009925,GO:0030159,GO:0030276,GO:0030301,GO:0030424,GO:0030665,GO:0031623,GO:0034383,GO:0035591,GO:0035612,GO:0035615,GO:0035650,GO:0042632,GO:0042982,GO:0043393,GO:0048260,GO:0050750,GO:0055037,GO:0061024,GO:0071345,GO:0090118,GO:0090205,GO:1903076,GO:1904707,GO:1905581,GO:1905602" "amyloid-beta binding|phosphotyrosine residue binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|early endosome|cytosol|neurofilament|plasma membrane|receptor-mediated endocytosis|cholesterol metabolic process|cytoplasmic side of plasma membrane|basal plasma membrane|signaling receptor complex adaptor activity|clathrin binding|cholesterol transport|axon|clathrin-coated vesicle membrane|receptor internalization|low-density lipoprotein particle clearance|signaling adaptor activity|AP-2 adaptor complex binding|clathrin adaptor activity|AP-1 adaptor complex binding|cholesterol homeostasis|amyloid precursor protein metabolic process|regulation of protein binding|positive regulation of receptor-mediated endocytosis|low-density lipoprotein particle receptor binding|recycling endosome|membrane organization|cellular response to cytokine stimulus|receptor-mediated endocytosis involved in cholesterol transport|positive regulation of cholesterol metabolic process|regulation of protein localization to plasma membrane|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of low-density lipoprotein particle clearance|positive regulation of receptor-mediated endocytosis involved in cholesterol transport" "hsa04144,hsa04979" Endocytosis|Cholesterol metabolism LDOC1 2966.677932 2731.246511 3202.109354 1.172398515 0.229463046 0.470970077 1 35.51424917 43.43039976 23641 LDOC1 regulator of NFKB signaling "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0008285,GO:0071222,GO:0071225" protein binding|nucleus|nucleoplasm|nucleolus|negative regulation of cell population proliferation|cellular response to lipopolysaccharide|cellular response to muramyl dipeptide LEAP2 9.508469716 10.14955968 8.867379749 0.873671373 -0.194837375 0.972452314 1 0.597026008 0.54407314 116842 liver enriched antimicrobial peptide 2 "GO:0005576,GO:0019730,GO:0042742" extracellular region|antimicrobial humoral response|defense response to bacterium LEF1 193.9498701 158.3331311 229.5666091 1.449896225 0.535949645 0.325899849 1 2.926647636 4.426121038 51176 lymphoid enhancer binding factor 1 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001569,GO:0001649,GO:0001756,GO:0001837,GO:0002040,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006357,GO:0007223,GO:0008013,GO:0008284,GO:0008301,GO:0010628,GO:0010718,GO:0021542,GO:0021861,GO:0021873,GO:0021943,GO:0030111,GO:0030223,GO:0030284,GO:0030326,GO:0030331,GO:0030335,GO:0030509,GO:0030854,GO:0030879,GO:0032696,GO:0032713,GO:0032714,GO:0032993,GO:0033153,GO:0042100,GO:0042393,GO:0042475,GO:0042826,GO:0043066,GO:0043392,GO:0043401,GO:0043565,GO:0043586,GO:0043923,GO:0043966,GO:0043967,GO:0045063,GO:0045295,GO:0045588,GO:0045843,GO:0045892,GO:0045893,GO:0045944,GO:0048341,GO:0050909,GO:0060033,GO:0060070,GO:0060325,GO:0060326,GO:0060710,GO:0061153,GO:0062009,GO:0070016,GO:0070742,GO:0071345,GO:0071353,GO:0071864,GO:0071866,GO:0071899,GO:1902262,GO:1904837,GO:1990837,GO:1990907" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|branching involved in blood vessel morphogenesis|osteoblast differentiation|somitogenesis|epithelial to mesenchymal transition|sprouting angiogenesis|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|Wnt signaling pathway, calcium modulating pathway|beta-catenin binding|positive regulation of cell population proliferation|DNA binding, bending|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|dentate gyrus development|forebrain radial glial cell differentiation|forebrain neuroblast division|formation of radial glial scaffolds|regulation of Wnt signaling pathway|neutrophil differentiation|estrogen receptor activity|embryonic limb morphogenesis|estrogen receptor binding|positive regulation of cell migration|BMP signaling pathway|positive regulation of granulocyte differentiation|mammary gland development|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|protein-DNA complex|T cell receptor V(D)J recombination|B cell proliferation|histone binding|odontogenesis of dentin-containing tooth|histone deacetylase binding|negative regulation of apoptotic process|negative regulation of DNA binding|steroid hormone mediated signaling pathway|sequence-specific DNA binding|tongue development|positive regulation by host of viral transcription|histone H3 acetylation|histone H4 acetylation|T-helper 1 cell differentiation|gamma-catenin binding|positive regulation of gamma-delta T cell differentiation|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|paraxial mesoderm formation|sensory perception of taste|anatomical structure regression|canonical Wnt signaling pathway|face morphogenesis|cell chemotaxis|chorio-allantoic fusion|trachea gland development|secondary palate development|armadillo repeat domain binding|C2H2 zinc finger domain binding|cellular response to cytokine stimulus|cellular response to interleukin-4|positive regulation of cell proliferation in bone marrow|negative regulation of apoptotic process in bone marrow cell|negative regulation of estrogen receptor binding|apoptotic process involved in blood vessel morphogenesis|beta-catenin-TCF complex assembly|sequence-specific double-stranded DNA binding|beta-catenin-TCF complex" "hsa04310,hsa04390,hsa04520,hsa04916,hsa04934,hsa05132,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412" Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Salmonella infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy HMG LEKR1 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.073562642 0.033105208 389170 "leucine, glutamate and lysine rich 1" LEMD2 1115.920577 1051.494383 1180.346771 1.122542155 0.166769624 0.630959631 1 6.54553602 7.664146647 221496 LEM domain nuclear envelope protein 2 "GO:0000785,GO:0005515,GO:0005635,GO:0005637,GO:0005639,GO:0005783,GO:0006998,GO:0016020,GO:0016021,GO:0022008,GO:0030514,GO:0031490,GO:0031965,GO:0035914,GO:0043409,GO:0051898,GO:0060914,GO:0071168" chromatin|protein binding|nuclear envelope|nuclear inner membrane|integral component of nuclear inner membrane|endoplasmic reticulum|nuclear envelope organization|membrane|integral component of membrane|neurogenesis|negative regulation of BMP signaling pathway|chromatin DNA binding|nuclear membrane|skeletal muscle cell differentiation|negative regulation of MAPK cascade|negative regulation of protein kinase B signaling|heart formation|protein localization to chromatin LEMD3 663.9840931 667.8410272 660.1271591 0.988449544 -0.01676077 0.969334356 1 7.076107118 7.29566416 23592 LEM domain containing 3 "GO:0005515,GO:0005637,GO:0005639,GO:0006998,GO:0016020,GO:0016021,GO:0030512,GO:0030514,GO:0031490,GO:0031965,GO:0032926,GO:1902531" protein binding|nuclear inner membrane|integral component of nuclear inner membrane|nuclear envelope organization|membrane|integral component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|chromatin DNA binding|nuclear membrane|negative regulation of activin receptor signaling pathway|regulation of intracellular signal transduction LENG1 119.8796111 112.6601125 127.0991097 1.128164236 0.173977108 0.795447523 1 4.131670714 4.861988862 79165 leukocyte receptor cluster member 1 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process LENG8 2050.672752 1909.132177 2192.213327 1.148277397 0.199471206 0.535617546 1 12.78302614 15.31074851 114823 leukocyte receptor cluster member 8 "GO:0005515,GO:0005634" protein binding|nucleus LENG9 70.15617123 81.19647747 59.11586499 0.728059478 -0.457871781 0.554525318 1 2.008947308 1.525637432 94059 leukocyte receptor cluster member 9 GO:0046872 metal ion binding LEO1 490.9029251 521.6873677 460.1184825 0.881981261 -0.181180091 0.661601923 1 11.54286797 10.61913191 123169 "LEO1 homolog, Paf1/RNA polymerase II complex component" "GO:0001650,GO:0001711,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0006366,GO:0006368,GO:0006378,GO:0010390,GO:0016055,GO:0016567,GO:0016593,GO:0019827,GO:0031442,GO:0032968,GO:0033523,GO:0045638,GO:1904837,GO:1990269" fibrillar center|endodermal cell fate commitment|protein binding|nucleus|nucleoplasm|centrosome|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA polyadenylation|histone monoubiquitination|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|stem cell population maintenance|positive regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|histone H2B ubiquitination|negative regulation of myeloid cell differentiation|beta-catenin-TCF complex assembly|RNA polymerase II C-terminal domain phosphoserine binding LEPR 137.8843162 97.43577296 178.3328594 1.830260632 0.872049105 0.153295008 1 0.447842651 0.854976779 3953 leptin receptor "GO:0001525,GO:0001934,GO:0004888,GO:0004896,GO:0005515,GO:0005576,GO:0005977,GO:0006112,GO:0006909,GO:0007166,GO:0007275,GO:0008203,GO:0009897,GO:0010507,GO:0014009,GO:0016021,GO:0016323,GO:0017046,GO:0019221,GO:0019953,GO:0019955,GO:0030217,GO:0033210,GO:0038021,GO:0042593,GO:0042802,GO:0043235,GO:0044321,GO:0045721,GO:0046850,GO:0051049,GO:0051346,GO:0060259,GO:0097009,GO:0098868,GO:0120162,GO:0150104" angiogenesis|positive regulation of protein phosphorylation|transmembrane signaling receptor activity|cytokine receptor activity|protein binding|extracellular region|glycogen metabolic process|energy reserve metabolic process|phagocytosis|cell surface receptor signaling pathway|multicellular organism development|cholesterol metabolic process|external side of plasma membrane|negative regulation of autophagy|glial cell proliferation|integral component of membrane|basolateral plasma membrane|peptide hormone binding|cytokine-mediated signaling pathway|sexual reproduction|cytokine binding|T cell differentiation|leptin-mediated signaling pathway|leptin receptor activity|glucose homeostasis|identical protein binding|receptor complex|response to leptin|negative regulation of gluconeogenesis|regulation of bone remodeling|regulation of transport|negative regulation of hydrolase activity|regulation of feeding behavior|energy homeostasis|bone growth|positive regulation of cold-induced thermogenesis|transport across blood-brain barrier "hsa04060,hsa04080,hsa04152,hsa04630,hsa04920,hsa04932" Cytokine-cytokine receptor interaction|Neuroactive ligand-receptor interaction|AMPK signaling pathway|JAK-STAT signaling pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease LEPROT 1185.642261 968.2679938 1403.016529 1.448996082 0.535053694 0.118786211 1 10.00599021 15.12318325 54741 leptin receptor overlapping transcript "GO:0000139,GO:0005102,GO:0005515,GO:0005768,GO:0005794,GO:0010008,GO:0016021,GO:0032511,GO:0046426,GO:0060400,GO:1903955,GO:2000009" Golgi membrane|signaling receptor binding|protein binding|endosome|Golgi apparatus|endosome membrane|integral component of membrane|late endosome to vacuole transport via multivesicular body sorting pathway|negative regulation of receptor signaling pathway via JAK-STAT|negative regulation of growth hormone receptor signaling pathway|positive regulation of protein targeting to mitochondrion|negative regulation of protein localization to cell surface LEPROTL1 678.5025164 751.0674166 605.9376162 0.806768611 -0.309773142 0.415864627 1 8.971442227 7.54965641 23484 leptin receptor overlapping transcript like 1 "GO:0005515,GO:0005768,GO:0016021,GO:0032511,GO:0042802,GO:2000009" protein binding|endosome|integral component of membrane|late endosome to vacuole transport via multivesicular body sorting pathway|identical protein binding|negative regulation of protein localization to cell surface LETM1 737.0460771 812.9797307 661.1124235 0.813196687 -0.298323757 0.425123504 1 7.968754662 6.759304112 3954 leucine zipper and EF-hand containing transmembrane protein 1 "GO:0005509,GO:0005515,GO:0005739,GO:0005743,GO:0006851,GO:0006875,GO:0015369,GO:0016021,GO:0034214,GO:0042407,GO:0043022,GO:0051260,GO:0051560,GO:0051562,GO:0099093,GO:1900069" calcium ion binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|cellular metal ion homeostasis|calcium:proton antiporter activity|integral component of membrane|protein hexamerization|cristae formation|ribosome binding|protein homooligomerization|mitochondrial calcium ion homeostasis|negative regulation of mitochondrial calcium ion concentration|calcium export from the mitochondrion|regulation of cellular hyperosmotic salinity response LETM2 78.61999343 87.28621328 69.95377357 0.801429813 -0.319351916 0.673138053 1 0.643203663 0.537687491 137994 leucine zipper and EF-hand containing transmembrane protein 2 "GO:0005743,GO:0006875,GO:0016021,GO:0043022" mitochondrial inner membrane|cellular metal ion homeostasis|integral component of membrane|ribosome binding LETMD1 1520.14745 1238.246281 1802.048618 1.455323262 0.541339646 0.102339221 1 13.50695798 20.50373356 25875 LETM1 domain containing 1 "GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005741,GO:0016021,GO:0043022" protein binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial outer membrane|integral component of membrane|ribosome binding LFNG 21.70278711 35.52345889 7.882115332 0.221884793 -2.172117298 0.054181454 1 0.557526456 0.129035423 3955 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase "GO:0001756,GO:0002315,GO:0005576,GO:0008375,GO:0008593,GO:0009887,GO:0014807,GO:0030173,GO:0030217,GO:0033829,GO:0046872,GO:1902367,GO:1903561" somitogenesis|marginal zone B cell differentiation|extracellular region|acetylglucosaminyltransferase activity|regulation of Notch signaling pathway|animal organ morphogenesis|regulation of somitogenesis|integral component of Golgi membrane|T cell differentiation|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|metal ion binding|negative regulation of Notch signaling pathway involved in somitogenesis|extracellular vesicle "hsa00514,hsa04330,hsa05165" Other types of O-glycan biosynthesis|Notch signaling pathway|Human papillomavirus infection LGALS1 25634.38627 29387.03511 21881.73743 0.744605141 -0.425452517 0.261309687 1 2818.844047 2189.33898 3956 galectin 1 "GO:0002317,GO:0003723,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005788,GO:0005829,GO:0006915,GO:0009986,GO:0010812,GO:0010977,GO:0030246,GO:0030395,GO:0031295,GO:0034120,GO:0035900,GO:0042493,GO:0042802,GO:0042981,GO:0043123,GO:0043236,GO:0043687,GO:0044267,GO:0045445,GO:0046598,GO:0048678,GO:0062023,GO:0070062,GO:0071333,GO:0071407,GO:2001200" plasma cell differentiation|RNA binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|endoplasmic reticulum lumen|cytosol|apoptotic process|cell surface|negative regulation of cell-substrate adhesion|negative regulation of neuron projection development|carbohydrate binding|lactose binding|T cell costimulation|positive regulation of erythrocyte aggregation|response to isolation stress|response to drug|identical protein binding|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|laminin binding|post-translational protein modification|cellular protein metabolic process|myoblast differentiation|positive regulation of viral entry into host cell|response to axon injury|collagen-containing extracellular matrix|extracellular exosome|cellular response to glucose stimulus|cellular response to organic cyclic compound|positive regulation of dendritic cell differentiation LGALS3 1120.898118 1156.034848 1085.761387 0.939211641 -0.090477804 0.795504906 1 58.6076945 57.41614555 3958 galectin 3 "GO:0001772,GO:0002548,GO:0003723,GO:0004864,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005681,GO:0005737,GO:0005743,GO:0005886,GO:0006397,GO:0008380,GO:0009986,GO:0016020,GO:0019863,GO:0019903,GO:0030246,GO:0030593,GO:0030667,GO:0030855,GO:0031334,GO:0042056,GO:0042129,GO:0043236,GO:0043312,GO:0045087,GO:0045637,GO:0045806,GO:0048245,GO:0048246,GO:0050860,GO:0050918,GO:0062023,GO:0070062,GO:0070232,GO:0071674,GO:0071677,GO:0090280,GO:0101003,GO:1902041,GO:1903078,GO:1903614,GO:2000521,GO:2001189,GO:2001200,GO:2001237" immunological synapse|monocyte chemotaxis|RNA binding|protein phosphatase inhibitor activity|protein binding|extracellular region|extracellular space|nucleus|spliceosomal complex|cytoplasm|mitochondrial inner membrane|plasma membrane|mRNA processing|RNA splicing|cell surface|membrane|IgE binding|protein phosphatase binding|carbohydrate binding|neutrophil chemotaxis|secretory granule membrane|epithelial cell differentiation|positive regulation of protein-containing complex assembly|chemoattractant activity|regulation of T cell proliferation|laminin binding|neutrophil degranulation|innate immune response|regulation of myeloid cell differentiation|negative regulation of endocytosis|eosinophil chemotaxis|macrophage chemotaxis|negative regulation of T cell receptor signaling pathway|positive chemotaxis|collagen-containing extracellular matrix|extracellular exosome|regulation of T cell apoptotic process|mononuclear cell migration|positive regulation of mononuclear cell migration|positive regulation of calcium ion import|ficolin-1-rich granule membrane|regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of protein localization to plasma membrane|negative regulation of protein tyrosine phosphatase activity|negative regulation of immunological synapse formation|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|positive regulation of dendritic cell differentiation|negative regulation of extrinsic apoptotic signaling pathway LGALS3BP 6497.136689 6925.044572 6069.228806 0.876417291 -0.190310147 0.559402118 1 159.2775102 145.6066887 3959 galectin 3 binding protein "GO:0002576,GO:0005044,GO:0005515,GO:0005576,GO:0005615,GO:0006897,GO:0006968,GO:0007155,GO:0007165,GO:0016020,GO:0031089,GO:0062023,GO:0070062,GO:0072562" platelet degranulation|scavenger receptor activity|protein binding|extracellular region|extracellular space|endocytosis|cellular defense response|cell adhesion|signal transduction|membrane|platelet dense granule lumen|collagen-containing extracellular matrix|extracellular exosome|blood microparticle LGALS8 1760.817461 1828.950655 1692.684268 0.925494771 -0.111703256 0.732677483 1 9.713705802 9.377235974 3964 galectin 8 "GO:0005178,GO:0005515,GO:0005615,GO:0005737,GO:0005829,GO:0016020,GO:0030246,GO:0031410,GO:0098586,GO:0098792,GO:1904977" integrin binding|protein binding|extracellular space|cytoplasm|cytosol|membrane|carbohydrate binding|cytoplasmic vesicle|cellular response to virus|xenophagy|lymphatic endothelial cell migration LGALSL 236.6940653 285.2026271 188.1855036 0.659830891 -0.599831773 0.240189009 1 3.745982087 2.578186143 29094 galectin like "GO:0005515,GO:0030246" protein binding|carbohydrate binding LGMN 1320.849886 1488.940406 1152.759367 0.774214578 -0.369194622 0.273697397 1 33.23471965 26.83918314 5641 legumain "GO:0002224,GO:0003014,GO:0004197,GO:0005576,GO:0005737,GO:0005764,GO:0005770,GO:0006508,GO:0006624,GO:0007613,GO:0008233,GO:0008284,GO:0008306,GO:0010447,GO:0010629,GO:0019886,GO:0032801,GO:0035729,GO:0036021,GO:0040015,GO:0042359,GO:0043202,GO:0043524,GO:0045177,GO:0045931,GO:0048156,GO:0048471,GO:0051603,GO:0070062,GO:0071277,GO:0090026,GO:0097061,GO:0097202,GO:0097264,GO:1900273,GO:1901185,GO:1904646,GO:2001028" toll-like receptor signaling pathway|renal system process|cysteine-type endopeptidase activity|extracellular region|cytoplasm|lysosome|late endosome|proteolysis|vacuolar protein processing|memory|peptidase activity|positive regulation of cell population proliferation|associative learning|response to acidic pH|negative regulation of gene expression|antigen processing and presentation of exogenous peptide antigen via MHC class II|receptor catabolic process|cellular response to hepatocyte growth factor stimulus|endolysosome lumen|negative regulation of multicellular organism growth|vitamin D metabolic process|lysosomal lumen|negative regulation of neuron apoptotic process|apical part of cell|positive regulation of mitotic cell cycle|tau protein binding|perinuclear region of cytoplasm|proteolysis involved in cellular protein catabolic process|extracellular exosome|cellular response to calcium ion|positive regulation of monocyte chemotaxis|dendritic spine organization|activation of cysteine-type endopeptidase activity|self proteolysis|positive regulation of long-term synaptic potentiation|negative regulation of ERBB signaling pathway|cellular response to amyloid-beta|positive regulation of endothelial cell chemotaxis "hsa04142,hsa04612" Lysosome|Antigen processing and presentation LGR4 539.5223344 545.031355 534.0133138 0.979784574 -0.029463518 0.946310516 1 5.257888643 5.373508139 55366 leucine rich repeat containing G protein-coupled receptor 4 "GO:0001649,GO:0001818,GO:0001942,GO:0004888,GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007189,GO:0007190,GO:0007283,GO:0008528,GO:0009755,GO:0016500,GO:0030282,GO:0030539,GO:0032922,GO:0034122,GO:0036335,GO:0045087,GO:0045892,GO:0045893,GO:0046849,GO:0048565,GO:0061290,GO:0072202,GO:0072224,GO:0072282,GO:0090190,GO:0090263,GO:0120163,GO:2001013" "osteoblast differentiation|negative regulation of cytokine production|hair follicle development|transmembrane signaling receptor activity|G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|spermatogenesis|G protein-coupled peptide receptor activity|hormone-mediated signaling pathway|protein-hormone receptor activity|bone mineralization|male genitalia development|circadian regulation of gene expression|negative regulation of toll-like receptor signaling pathway|intestinal stem cell homeostasis|innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|bone remodeling|digestive tract development|canonical Wnt signaling pathway involved in metanephric kidney development|cell differentiation involved in metanephros development|metanephric glomerulus development|metanephric nephron tubule morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt signaling pathway|negative regulation of cold-induced thermogenesis|epithelial cell proliferation involved in renal tubule morphogenesis" hsa04310 Wnt signaling pathway LGSN 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.01086764 0.016506236 51557 "lengsin, lens protein with glutamine synthetase domain" "GO:0004356,GO:0005737,GO:0005886,GO:0006542,GO:0016020,GO:0019740" glutamate-ammonia ligase activity|cytoplasm|plasma membrane|glutamine biosynthetic process|membrane|nitrogen utilization LHFPL2 1925.070098 2415.595205 1434.54499 0.593868123 -0.751785499 0.020471054 0.616714654 15.93609163 9.87160484 10184 LHFPL tetraspan subfamily member 2 "GO:0002576,GO:0003674,GO:0005515,GO:0005575,GO:0005886,GO:0007338,GO:0008150,GO:0016020,GO:0016021,GO:0031092,GO:0046545,GO:0046546,GO:1905516" platelet degranulation|molecular_function|protein binding|cellular_component|plasma membrane|single fertilization|biological_process|membrane|integral component of membrane|platelet alpha granule membrane|development of primary female sexual characteristics|development of primary male sexual characteristics|positive regulation of fertilization LHFPL5 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.049331995 0.074927539 222662 LHFPL tetraspan subfamily member 5 "GO:0005515,GO:0005886,GO:0006811,GO:0007605,GO:0016020,GO:0016021,GO:0016324,GO:0032426,GO:0050910,GO:0050974,GO:0060088" protein binding|plasma membrane|ion transport|sensory perception of sound|membrane|integral component of membrane|apical plasma membrane|stereocilium tip|detection of mechanical stimulus involved in sensory perception of sound|detection of mechanical stimulus involved in sensory perception|auditory receptor cell stereocilium organization LHFPL6 427.6666154 341.0252054 514.3080254 1.508123204 0.592754293 0.164071306 1 8.101183671 12.74386701 10186 LHFPL tetraspan subfamily member 6 "GO:0016020,GO:0016021" membrane|integral component of membrane LHPP 44.55686378 48.71788648 40.39584108 0.82917885 -0.270244777 0.777459936 1 0.33836932 0.292654445 64077 phospholysine phosphohistidine inorganic pyrophosphate phosphatase "GO:0000287,GO:0004427,GO:0005515,GO:0005634,GO:0005829,GO:0006470,GO:0006796,GO:0009168,GO:0016311,GO:0016607,GO:0016791,GO:0042803,GO:0101006" magnesium ion binding|inorganic diphosphatase activity|protein binding|nucleus|cytosol|protein dephosphorylation|phosphate-containing compound metabolic process|purine ribonucleoside monophosphate biosynthetic process|dephosphorylation|nuclear speck|phosphatase activity|protein homodimerization activity|protein histidine phosphatase activity hsa00190 Oxidative phosphorylation LHX1 790.2179424 844.4433657 735.9925192 0.871571202 -0.198309567 0.591594384 1 12.48702991 11.35214563 3975 LIM homeobox 1 "GO:0000785,GO:0000977,GO:0000981,GO:0000987,GO:0001655,GO:0001657,GO:0001658,GO:0001702,GO:0001705,GO:0001706,GO:0001822,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0006366,GO:0007267,GO:0007389,GO:0007399,GO:0008045,GO:0009653,GO:0009791,GO:0009880,GO:0009887,GO:0009948,GO:0009952,GO:0009953,GO:0010468,GO:0010842,GO:0021517,GO:0021527,GO:0021537,GO:0021549,GO:0021702,GO:0021871,GO:0021937,GO:0030182,GO:0032525,GO:0032991,GO:0035502,GO:0035846,GO:0035847,GO:0035849,GO:0035852,GO:0040019,GO:0044344,GO:0045892,GO:0045893,GO:0046872,GO:0048382,GO:0048646,GO:0048703,GO:0048793,GO:0060059,GO:0060065,GO:0060066,GO:0060067,GO:0060068,GO:0060322,GO:0060429,GO:0061205,GO:0072049,GO:0072050,GO:0072077,GO:0072177,GO:0072178,GO:0072197,GO:0072224,GO:0072278,GO:0072283,GO:0072284,GO:0090009,GO:0090190,GO:0097379,GO:0097477,GO:1990837,GO:2000543,GO:2000744,GO:2000768" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|urogenital system development|ureteric bud development|branching involved in ureteric bud morphogenesis|gastrulation with mouth forming second|ectoderm formation|endoderm formation|kidney development|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|cell-cell signaling|pattern specification process|nervous system development|motor neuron axon guidance|anatomical structure morphogenesis|post-embryonic development|embryonic pattern specification|animal organ morphogenesis|anterior/posterior axis specification|anterior/posterior pattern specification|dorsal/ventral pattern formation|regulation of gene expression|retina layer formation|ventral spinal cord development|spinal cord association neuron differentiation|telencephalon development|cerebellum development|cerebellar Purkinje cell differentiation|forebrain regionalization|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|neuron differentiation|somite rostral/caudal axis specification|protein-containing complex|metanephric part of ureteric bud development|oviduct epithelium development|uterine epithelium development|nephric duct elongation|horizontal cell localization|positive regulation of embryonic development|cellular response to fibroblast growth factor stimulus|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|mesendoderm development|anatomical structure formation involved in morphogenesis|embryonic viscerocranium morphogenesis|pronephros development|embryonic retina morphogenesis in camera-type eye|uterus development|oviduct development|cervix development|vagina development|head development|epithelium development|paramesonephric duct development|comma-shaped body morphogenesis|S-shaped body morphogenesis|renal vesicle morphogenesis|mesonephric duct development|nephric duct morphogenesis|ureter morphogenesis|metanephric glomerulus development|metanephric comma-shaped body morphogenesis|metanephric renal vesicle morphogenesis|metanephric S-shaped body morphogenesis|primitive streak formation|positive regulation of branching involved in ureteric bud morphogenesis|dorsal spinal cord interneuron posterior axon guidance|lateral motor column neuron migration|sequence-specific double-stranded DNA binding|positive regulation of gastrulation|positive regulation of anterior head development|positive regulation of nephron tubule epithelial cell differentiation" LHX2 3.463271234 1.014955968 5.911586499 5.824475823 2.542128219 0.321345721 1 0.020947001 0.127260791 9355 LIM homeobox 2 "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0030182,GO:0045893,GO:0046872" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|neuron differentiation|positive regulation of transcription, DNA-templated|metal ion binding" Homeobox LHX4 19.50957164 20.29911937 18.72002391 0.922208672 -0.116834863 0.96691613 1 0.139457242 0.134148618 89884 LIM homeobox 4 "GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0001890,GO:0005515,GO:0005634,GO:0006357,GO:0008045,GO:0008327,GO:0009887,GO:0021526,GO:0030182,GO:0043066,GO:0043565,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|placenta development|protein binding|nucleus|regulation of transcription by RNA polymerase II|motor neuron axon guidance|methyl-CpG binding|animal organ morphogenesis|medial motor column neuron differentiation|neuron differentiation|negative regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" LHX6 33.73652258 16.23929549 51.23374966 3.154924404 1.657605437 0.087748466 1 0.162928492 0.536169277 26468 LIM homeobox 6 "GO:0000785,GO:0000977,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0021799,GO:0021800,GO:0021853,GO:0021884,GO:0030182,GO:0046872,GO:0048469,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration|cerebral cortex GABAergic interneuron migration|forebrain neuron development|neuron differentiation|metal ion binding|cell maturation|sequence-specific double-stranded DNA binding" LHX9 22.42082756 17.25425146 27.58740366 1.598875716 0.6770578 0.544660788 1 0.097366793 0.162383352 56956 LIM homeobox 9 "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0008283,GO:0008584,GO:0008585,GO:0030182,GO:0035262,GO:0045892,GO:0046872,GO:0097380,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|cell population proliferation|male gonad development|female gonad development|neuron differentiation|gonad morphogenesis|negative regulation of transcription, DNA-templated|metal ion binding|dorsal spinal cord interneuron anterior axon guidance|sequence-specific double-stranded DNA binding" LIAS 121.161791 132.9592319 109.3643502 0.822540479 -0.281841416 0.664735378 1 1.780988109 1.528038263 11019 lipoic acid synthetase "GO:0001843,GO:0005739,GO:0005759,GO:0006954,GO:0006979,GO:0009107,GO:0009249,GO:0016992,GO:0032496,GO:0034641,GO:0046872,GO:0051539,GO:0102552,GO:0102553" "neural tube closure|mitochondrion|mitochondrial matrix|inflammatory response|response to oxidative stress|lipoate biosynthetic process|protein lipoylation|lipoate synthase activity|response to lipopolysaccharide|cellular nitrogen compound metabolic process|metal ion binding|4 iron, 4 sulfur cluster binding|lipoyl synthase activity (acting on glycine-cleavage complex H protein|lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)" hsa00785 Lipoic acid metabolism LIF 10649.26017 10105.91658 11192.60377 1.107529801 0.147345518 0.663247691 1 121.4303732 140.2809442 3976 LIF interleukin 6 family cytokine "GO:0001974,GO:0005102,GO:0005125,GO:0005146,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006955,GO:0007260,GO:0007275,GO:0007566,GO:0008083,GO:0008284,GO:0008285,GO:0019221,GO:0019827,GO:0033138,GO:0033141,GO:0033630,GO:0042531,GO:0043410,GO:0045595,GO:0045651,GO:0045835,GO:0045944,GO:0046697,GO:0046888,GO:0048286,GO:0048644,GO:0048666,GO:0048711,GO:0048861,GO:0048863,GO:0050731,GO:0060426,GO:0060463,GO:0060707,GO:0070373,GO:0072108,GO:0072307,GO:1900182,GO:1901676,GO:1903025" blood vessel remodeling|signaling receptor binding|cytokine activity|leukemia inhibitory factor receptor binding|protein binding|extracellular region|extracellular space|cytosol|immune response|tyrosine phosphorylation of STAT protein|multicellular organism development|embryo implantation|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|cytokine-mediated signaling pathway|stem cell population maintenance|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of cell adhesion mediated by integrin|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of MAPK cascade|regulation of cell differentiation|positive regulation of macrophage differentiation|negative regulation of meiotic nuclear division|positive regulation of transcription by RNA polymerase II|decidualization|negative regulation of hormone secretion|lung alveolus development|muscle organ morphogenesis|neuron development|positive regulation of astrocyte differentiation|leukemia inhibitory factor signaling pathway|stem cell differentiation|positive regulation of peptidyl-tyrosine phosphorylation|lung vasculature development|lung lobe morphogenesis|trophoblast giant cell differentiation|negative regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|regulation of metanephric nephron tubule epithelial cell differentiation|positive regulation of protein localization to nucleus|positive regulation of histone H3-K27 acetylation|regulation of RNA polymerase II regulatory region sequence-specific DNA binding "hsa04060,hsa04550,hsa04630,hsa04668" Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|TNF signaling pathway LIFR 479.6196433 491.2386887 468.0005979 0.952694909 -0.069913815 0.870199172 1 2.200947151 2.187154128 3977 LIF receptor subunit alpha "GO:0001959,GO:0004896,GO:0004897,GO:0004923,GO:0004924,GO:0005127,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0008284,GO:0009897,GO:0019221,GO:0019838,GO:0019955,GO:0034097,GO:0038165,GO:0043235,GO:0048861,GO:0070062,GO:0070120" regulation of cytokine-mediated signaling pathway|cytokine receptor activity|ciliary neurotrophic factor receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|ciliary neurotrophic factor receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|positive regulation of cell population proliferation|external side of plasma membrane|cytokine-mediated signaling pathway|growth factor binding|cytokine binding|response to cytokine|oncostatin-M-mediated signaling pathway|receptor complex|leukemia inhibitory factor signaling pathway|extracellular exosome|ciliary neurotrophic factor-mediated signaling pathway "hsa04060,hsa04550,hsa04630" Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway LIG1 1086.507143 926.6547991 1246.359487 1.345009477 0.427616338 0.218655372 1 15.01817489 21.06970387 3978 DNA ligase 1 "GO:0003677,GO:0003909,GO:0003910,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006266,GO:0006273,GO:0006281,GO:0006283,GO:0006284,GO:0006297,GO:0006298,GO:0009653,GO:0033151,GO:0043231,GO:0046872,GO:0051301,GO:0071897,GO:1903461" "DNA binding|DNA ligase activity|DNA ligase (ATP) activity|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|DNA ligation|lagging strand elongation|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair, DNA gap filling|mismatch repair|anatomical structure morphogenesis|V(D)J recombination|intracellular membrane-bounded organelle|metal ion binding|cell division|DNA biosynthetic process|Okazaki fragment processing involved in mitotic DNA replication" "hsa03030,hsa03410,hsa03420,hsa03430" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair LIG3 712.8801289 777.4562718 648.3039861 0.833878392 -0.262091089 0.486912709 1 7.998256645 6.956871566 3980 DNA ligase 3 "GO:0000724,GO:0003677,GO:0003909,GO:0003910,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0006266,GO:0006273,GO:0006283,GO:0006288,GO:0006297,GO:0006302,GO:0007049,GO:0008270,GO:0033151,GO:0043504,GO:0051301,GO:0070421,GO:0071897,GO:0090298,GO:0097681" "double-strand break repair via homologous recombination|DNA binding|DNA ligase activity|DNA ligase (ATP) activity|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|DNA ligation|lagging strand elongation|transcription-coupled nucleotide-excision repair|base-excision repair, DNA ligation|nucleotide-excision repair, DNA gap filling|double-strand break repair|cell cycle|zinc ion binding|V(D)J recombination|mitochondrial DNA repair|cell division|DNA ligase III-XRCC1 complex|DNA biosynthetic process|negative regulation of mitochondrial DNA replication|double-strand break repair via alternative nonhomologous end joining" hsa03410 Base excision repair LIG4 349.1720692 363.3542367 334.9899016 0.921937514 -0.117259122 0.800006531 1 4.166314297 4.006539656 3981 DNA ligase 4 "GO:0000012,GO:0000781,GO:0000793,GO:0001701,GO:0002328,GO:0003677,GO:0003909,GO:0003910,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005958,GO:0006260,GO:0006266,GO:0006297,GO:0006302,GO:0006303,GO:0007049,GO:0007417,GO:0008022,GO:0008283,GO:0010165,GO:0010332,GO:0016874,GO:0032807,GO:0033077,GO:0033151,GO:0033152,GO:0033153,GO:0035019,GO:0036464,GO:0043524,GO:0045190,GO:0046872,GO:0048146,GO:0050769,GO:0051102,GO:0051103,GO:0051276,GO:0051301,GO:0051402,GO:0070419,GO:0071285,GO:0071479,GO:0071897,GO:0075713,GO:0097680,GO:2001252" "single strand break repair|chromosome, telomeric region|condensed chromosome|in utero embryonic development|pro-B cell differentiation|DNA binding|DNA ligase activity|DNA ligase (ATP) activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA-dependent protein kinase-DNA ligase 4 complex|DNA replication|DNA ligation|nucleotide-excision repair, DNA gap filling|double-strand break repair|double-strand break repair via nonhomologous end joining|cell cycle|central nervous system development|protein C-terminus binding|cell population proliferation|response to X-ray|response to gamma radiation|ligase activity|DNA ligase IV complex|T cell differentiation in thymus|V(D)J recombination|immunoglobulin V(D)J recombination|T cell receptor V(D)J recombination|somatic stem cell population maintenance|cytoplasmic ribonucleoprotein granule|negative regulation of neuron apoptotic process|isotype switching|metal ion binding|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|chromosome organization|cell division|neuron apoptotic process|nonhomologous end joining complex|cellular response to lithium ion|cellular response to ionizing radiation|DNA biosynthetic process|establishment of integrated proviral latency|double-strand break repair via classical nonhomologous end joining|positive regulation of chromosome organization" hsa03450 Non-homologous end-joining LIMA1 1324.094677 1239.261237 1408.928116 1.136909695 0.185117665 0.58369481 1 14.14245377 16.77129768 51474 LIM domain and actin binding 1 "GO:0001725,GO:0001726,GO:0003785,GO:0005515,GO:0005829,GO:0005886,GO:0005925,GO:0008203,GO:0015629,GO:0016477,GO:0030299,GO:0030835,GO:0031526,GO:0031529,GO:0032154,GO:0042632,GO:0045296,GO:0046872,GO:0051015,GO:0051017" stress fiber|ruffle|actin monomer binding|protein binding|cytosol|plasma membrane|focal adhesion|cholesterol metabolic process|actin cytoskeleton|cell migration|intestinal cholesterol absorption|negative regulation of actin filament depolymerization|brush border membrane|ruffle organization|cleavage furrow|cholesterol homeostasis|cadherin binding|metal ion binding|actin filament binding|actin filament bundle assembly LIMCH1 242.157557 288.247495 196.0676189 0.680205803 -0.55595678 0.272838177 1 1.545819435 1.096768644 22998 LIM and calponin homology domains 1 "GO:0001725,GO:0001934,GO:0003779,GO:0005515,GO:0005737,GO:0016460,GO:0030336,GO:0031032,GO:0032034,GO:0046872,GO:0051496,GO:0051893,GO:0060327" stress fiber|positive regulation of protein phosphorylation|actin binding|protein binding|cytoplasm|myosin II complex|negative regulation of cell migration|actomyosin structure organization|myosin II head/neck binding|metal ion binding|positive regulation of stress fiber assembly|regulation of focal adhesion assembly|cytoplasmic actin-based contraction involved in cell motility LIMD1 1237.012099 1314.367979 1159.656218 0.882291898 -0.180672059 0.596547155 1 4.893274135 4.503267729 8994 LIM domain containing 1 "GO:0000932,GO:0001666,GO:0002076,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005925,GO:0006355,GO:0007010,GO:0008360,GO:0016310,GO:0016442,GO:0016477,GO:0033962,GO:0035195,GO:0035331,GO:0045668,GO:0045892,GO:0046872,GO:0061418,GO:0090090,GO:2000637" "P-body|response to hypoxia|osteoblast development|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|adherens junction|focal adhesion|regulation of transcription, DNA-templated|cytoskeleton organization|regulation of cell shape|phosphorylation|RISC complex|cell migration|P-body assembly|gene silencing by miRNA|negative regulation of hippo signaling|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|metal ion binding|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of canonical Wnt signaling pathway|positive regulation of gene silencing by miRNA" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species LIMD2 1563.160107 1551.867676 1574.452538 1.014553343 0.02084472 0.951667066 1 22.02820154 23.31148055 80774 LIM domain containing 2 "GO:0005515,GO:0005654,GO:0005829,GO:0046872" protein binding|nucleoplasm|cytosol|metal ion binding LIME1 165.3475104 156.3032191 174.3918017 1.115727512 0.157984728 0.791238011 1 4.818141597 5.607297916 54923 Lck interacting transmembrane adaptor 1 "GO:0002250,GO:0005515,GO:0005615,GO:0006357,GO:0014066,GO:0016021,GO:0019815,GO:0019901,GO:0043122,GO:0043405,GO:0050852,GO:0050853,GO:0051279,GO:1901222" adaptive immune response|protein binding|extracellular space|regulation of transcription by RNA polymerase II|regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|B cell receptor complex|protein kinase binding|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of MAP kinase activity|T cell receptor signaling pathway|B cell receptor signaling pathway|regulation of release of sequestered calcium ion into cytosol|regulation of NIK/NF-kappaB signaling LIMK1 3118.628125 3520.882254 2716.373996 0.771503788 -0.374254855 0.239567484 1 51.8674419 41.73965179 3984 LIM domain kinase 1 "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0007165,GO:0007266,GO:0007399,GO:0016607,GO:0030027,GO:0030036,GO:0031072,GO:0032233,GO:0038096,GO:0043005,GO:0045773,GO:0046872,GO:0051444,GO:0051496,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|signal transduction|Rho protein signal transduction|nervous system development|nuclear speck|lamellipodium|actin cytoskeleton organization|heat shock protein binding|positive regulation of actin filament bundle assembly|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|positive regulation of axon extension|metal ion binding|negative regulation of ubiquitin-protein transferase activity|positive regulation of stress fiber assembly|protein serine kinase activity|protein threonine kinase activity "hsa04360,hsa04666,hsa04810,hsa05135,hsa05170" Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Yersinia infection|Human immunodeficiency virus 1 infection LIMK2 819.0511535 761.2169763 876.8853307 1.151951885 0.204080459 0.578013975 1 7.86313572 9.448133938 3985 LIM domain kinase 2 "GO:0001934,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005801,GO:0005813,GO:0006468,GO:0007283,GO:0016310,GO:0030036,GO:0030953,GO:0046872,GO:0051650,GO:0060322,GO:0061303,GO:0072686,GO:0106310,GO:0106311,GO:1900182,GO:1902018" positive regulation of protein phosphorylation|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cis-Golgi network|centrosome|protein phosphorylation|spermatogenesis|phosphorylation|actin cytoskeleton organization|astral microtubule organization|metal ion binding|establishment of vesicle localization|head development|cornea development in camera-type eye|mitotic spindle|protein serine kinase activity|protein threonine kinase activity|positive regulation of protein localization to nucleus|negative regulation of cilium assembly "hsa04360,hsa04666,hsa04810,hsa05170" Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection LIMS1 739.8358452 835.308762 644.3629284 0.771406883 -0.374436076 0.316048985 1 6.786243504 5.460455577 3987 LIM zinc finger domain containing 1 "GO:0001837,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0007569,GO:0008270,GO:0010628,GO:0010811,GO:0019901,GO:0032991,GO:0033209,GO:0034329,GO:0043547,GO:0044877,GO:0045184,GO:0045216,GO:0045892,GO:0048471,GO:0050678,GO:0051894,GO:0071560,GO:0098609,GO:1900026,GO:1901224,GO:2001046" "epithelial to mesenchymal transition|protein binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|focal adhesion|cell aging|zinc ion binding|positive regulation of gene expression|positive regulation of cell-substrate adhesion|protein kinase binding|protein-containing complex|tumor necrosis factor-mediated signaling pathway|cell junction assembly|positive regulation of GTPase activity|protein-containing complex binding|establishment of protein localization|cell-cell junction organization|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm|regulation of epithelial cell proliferation|positive regulation of focal adhesion assembly|cellular response to transforming growth factor beta stimulus|cell-cell adhesion|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of NIK/NF-kappaB signaling|positive regulation of integrin-mediated signaling pathway" LIMS2 61.18759265 40.59823873 81.77694657 2.014297889 1.010277055 0.206214621 1 0.431603184 0.906826635 55679 LIM zinc finger domain containing 2 "GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0034329,GO:0043066,GO:0045216,GO:0046872,GO:0098609,GO:1900026,GO:2000178,GO:2000346,GO:2001046" nucleus|cytoplasm|cytosol|plasma membrane|cell-cell junction|focal adhesion|cell junction assembly|negative regulation of apoptotic process|cell-cell junction organization|metal ion binding|cell-cell adhesion|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of neural precursor cell proliferation|negative regulation of hepatocyte proliferation|positive regulation of integrin-mediated signaling pathway LIMS4 40.12317391 48.71788648 31.52846133 0.64716398 -0.627796782 0.496490411 1 0.593693235 0.400767382 100288695 LIM zinc finger domain containing 4 "GO:0005515,GO:0046872" protein binding|metal ion binding LIN37 154.2720694 140.0639236 168.4802152 1.202880877 0.266493777 0.655750399 1 6.266557965 7.862625878 55957 lin-37 DREAM MuvB core complex component "GO:0000122,GO:0005515,GO:0005654,GO:0017053,GO:0031523,GO:0051726" negative regulation of transcription by RNA polymerase II|protein binding|nucleoplasm|transcription repressor complex|Myb complex|regulation of cell cycle hsa04218 Cellular senescence LIN52 245.1430418 290.277407 200.0086766 0.689025986 -0.537369701 0.287324097 1 1.566491915 1.125847814 91750 lin-52 DREAM MuvB core complex component "GO:0005515,GO:0005654,GO:0006351,GO:0051726,GO:0070176" "protein binding|nucleoplasm|transcription, DNA-templated|regulation of cell cycle|DRM complex" hsa04218 Cellular senescence LIN54 375.6203074 420.1917709 331.048844 0.787851802 -0.344003816 0.43712603 1 3.383343537 2.78039539 132660 lin-54 DREAM MuvB core complex component "GO:0001067,GO:0003680,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0007049,GO:0016584,GO:0046872,GO:0051726" "regulatory region nucleic acid binding|minor groove of adenine-thymine-rich DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|cell cycle|nucleosome positioning|metal ion binding|regulation of cell cycle" hsa04218 Cellular senescence LIN7A 53.84264686 43.64310664 64.04218708 1.4674067 0.553268777 0.511440129 1 0.375211235 0.574304556 8825 "lin-7 homolog A, crumbs cell polarity complex component" "GO:0005515,GO:0005886,GO:0005911,GO:0005923,GO:0006887,GO:0007269,GO:0015031,GO:0016323,GO:0045199,GO:0045202,GO:0048489,GO:0048839,GO:0065003,GO:0070062,GO:0097016,GO:0097025,GO:0098793,GO:0098839,GO:1903361" protein binding|plasma membrane|cell-cell junction|bicellular tight junction|exocytosis|neurotransmitter secretion|protein transport|basolateral plasma membrane|maintenance of epithelial cell apical/basal polarity|synapse|synaptic vesicle transport|inner ear development|protein-containing complex assembly|extracellular exosome|L27 domain binding|MPP7-DLG1-LIN7 complex|presynapse|postsynaptic density membrane|protein localization to basolateral plasma membrane LIN7B 38.36320754 29.43372308 47.29269199 1.606751951 0.684147224 0.463778002 1 1.809119221 3.032019245 64130 "lin-7 homolog B, crumbs cell polarity complex component" "GO:0005515,GO:0005886,GO:0005911,GO:0005923,GO:0006887,GO:0007269,GO:0015031,GO:0016323,GO:0019904,GO:0030165,GO:0045199,GO:0045202,GO:0097016,GO:0097025,GO:0098793,GO:0098839,GO:1903361" protein binding|plasma membrane|cell-cell junction|bicellular tight junction|exocytosis|neurotransmitter secretion|protein transport|basolateral plasma membrane|protein domain specific binding|PDZ domain binding|maintenance of epithelial cell apical/basal polarity|synapse|L27 domain binding|MPP7-DLG1-LIN7 complex|presynapse|postsynaptic density membrane|protein localization to basolateral plasma membrane LIN7C 290.3706871 351.1747651 229.5666091 0.653710437 -0.613276364 0.199576113 1 3.673226555 2.504661636 55327 "lin-7 homolog C, crumbs cell polarity complex component" "GO:0002011,GO:0005515,GO:0005737,GO:0005886,GO:0005911,GO:0005923,GO:0006887,GO:0007269,GO:0008092,GO:0015031,GO:0016323,GO:0019904,GO:0030165,GO:0045199,GO:0045202,GO:0097016,GO:0097025,GO:0098793,GO:0098839,GO:0098978,GO:1903361" morphogenesis of an epithelial sheet|protein binding|cytoplasm|plasma membrane|cell-cell junction|bicellular tight junction|exocytosis|neurotransmitter secretion|cytoskeletal protein binding|protein transport|basolateral plasma membrane|protein domain specific binding|PDZ domain binding|maintenance of epithelial cell apical/basal polarity|synapse|L27 domain binding|MPP7-DLG1-LIN7 complex|presynapse|postsynaptic density membrane|glutamatergic synapse|protein localization to basolateral plasma membrane LIN9 303.6920457 285.2026271 322.1814642 1.129658122 0.175886224 0.713327315 1 2.840610999 3.347146516 286826 lin-9 DREAM MuvB core complex component "GO:0000003,GO:0003677,GO:0005515,GO:0005654,GO:0006351,GO:0006357,GO:0007049,GO:0017053,GO:0051726,GO:0071897" "reproduction|DNA binding|protein binding|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle|transcription repressor complex|regulation of cell cycle|DNA biosynthetic process" hsa04218 Cellular senescence other LINC02210-CRHR1 146.0930386 119.7648043 172.4212729 1.439665634 0.525733781 0.380783217 1 2.188980452 3.287149458 104909134 LINC02210-CRHR1 readthrough LINS1 305.6895444 320.726086 290.6530029 0.906234371 -0.142043885 0.767631785 1 2.789566341 2.636896925 55180 lines homolog 1 GO:0050890 cognition LIPA 2580.784847 2888.564686 2273.005009 0.786897735 -0.345751939 0.278317363 1 45.90386291 37.67761976 3988 "lipase A, lysosomal acid type" "GO:0000902,GO:0001650,GO:0004771,GO:0005654,GO:0005764,GO:0005829,GO:0006954,GO:0008283,GO:0016042,GO:0016125,GO:0016298,GO:0030324,GO:0034383,GO:0043202,GO:0043231,GO:0048771,GO:0048873" cell morphogenesis|fibrillar center|sterol esterase activity|nucleoplasm|lysosome|cytosol|inflammatory response|cell population proliferation|lipid catabolic process|sterol metabolic process|lipase activity|lung development|low-density lipoprotein particle clearance|lysosomal lumen|intracellular membrane-bounded organelle|tissue remodeling|homeostasis of number of cells within a tissue "hsa00100,hsa04142,hsa04979" Steroid biosynthesis|Lysosome|Cholesterol metabolism LIPC 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.062421298 0.021068473 3990 "lipase C, hepatic type" "GO:0004465,GO:0004620,GO:0004622,GO:0004806,GO:0005576,GO:0005615,GO:0005788,GO:0006633,GO:0008201,GO:0008970,GO:0016042,GO:0016298,GO:0019433,GO:0030169,GO:0034185,GO:0034364,GO:0034372,GO:0034373,GO:0034374,GO:0034375,GO:0034382,GO:0034638,GO:0042632,GO:0043691,GO:0051004,GO:0052739,GO:0052740,GO:0070328,GO:0102545" lipoprotein lipase activity|phospholipase activity|lysophospholipase activity|triglyceride lipase activity|extracellular region|extracellular space|endoplasmic reticulum lumen|fatty acid biosynthetic process|heparin binding|phospholipase A1 activity|lipid catabolic process|lipase activity|triglyceride catabolic process|low-density lipoprotein particle binding|apolipoprotein binding|high-density lipoprotein particle|very-low-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|chylomicron remnant clearance|phosphatidylcholine catabolic process|cholesterol homeostasis|reverse cholesterol transport|regulation of lipoprotein lipase activity|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|triglyceride homeostasis|phosphatidyl phospholipase B activity "hsa00561,hsa04979" Glycerolipid metabolism|Cholesterol metabolism LIPE 67.27732846 52.77771036 81.77694657 1.549459914 0.631765432 0.416959087 1 0.531095736 0.858359247 3991 "lipase E, hormone sensitive type" "GO:0004771,GO:0004806,GO:0005515,GO:0005811,GO:0005829,GO:0005901,GO:0006468,GO:0008203,GO:0016020,GO:0016042,GO:0019433,GO:0033878,GO:0042572,GO:0046340,GO:0046485,GO:0047372,GO:0050253,GO:0102258,GO:0102259" "sterol esterase activity|triglyceride lipase activity|protein binding|lipid droplet|cytosol|caveola|protein phosphorylation|cholesterol metabolic process|membrane|lipid catabolic process|triglyceride catabolic process|hormone-sensitive lipase activity|retinol metabolic process|diacylglycerol catabolic process|ether lipid metabolic process|acylglycerol lipase activity|retinyl-palmitate esterase activity|1,3-diacylglycerol acylhydrolase activity|1,2-diacylglycerol acylhydrolase activity" "hsa04024,hsa04152,hsa04371,hsa04714,hsa04910,hsa04923,hsa04925" cAMP signaling pathway|AMPK signaling pathway|Apelin signaling pathway|Thermogenesis|Insulin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion LIPG 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.017577001 0.0088989 9388 "lipase G, endothelial type" "GO:0004465,GO:0004620,GO:0004806,GO:0005576,GO:0005615,GO:0005769,GO:0005794,GO:0006629,GO:0006633,GO:0007584,GO:0008201,GO:0008283,GO:0008970,GO:0009395,GO:0009986,GO:0010983,GO:0016042,GO:0016298,GO:0019433,GO:0032376,GO:0034375,GO:0042632,GO:0043691,GO:0050746,GO:0052739,GO:0052740,GO:0055091" lipoprotein lipase activity|phospholipase activity|triglyceride lipase activity|extracellular region|extracellular space|early endosome|Golgi apparatus|lipid metabolic process|fatty acid biosynthetic process|response to nutrient|heparin binding|cell population proliferation|phospholipase A1 activity|phospholipid catabolic process|cell surface|positive regulation of high-density lipoprotein particle clearance|lipid catabolic process|lipase activity|triglyceride catabolic process|positive regulation of cholesterol transport|high-density lipoprotein particle remodeling|cholesterol homeostasis|reverse cholesterol transport|regulation of lipoprotein metabolic process|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|phospholipid homeostasis "hsa00561,hsa04979" Glycerolipid metabolism|Cholesterol metabolism LIPH 11.91224765 6.08973581 17.7347595 2.912237912 1.542128219 0.252853725 1 0.074805636 0.22723598 200879 lipase H "GO:0004465,GO:0004620,GO:0005615,GO:0005886,GO:0006633,GO:0006654,GO:0008201,GO:0016042,GO:0016298,GO:0019433" lipoprotein lipase activity|phospholipase activity|extracellular space|plasma membrane|fatty acid biosynthetic process|phosphatidic acid biosynthetic process|heparin binding|lipid catabolic process|lipase activity|triglyceride catabolic process LIPT1 55.5580759 59.88240213 51.23374966 0.85557272 -0.225037612 0.801247319 1 1.570601976 1.401648116 51601 lipoyltransferase 1 "GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006629,GO:0009249,GO:0016746,GO:0016979,GO:0017118,GO:0018215,GO:0034641" "protein binding|cytoplasm|mitochondrion|mitochondrial matrix|cellular protein modification process|lipid metabolic process|protein lipoylation|transferase activity, transferring acyl groups|lipoate-protein ligase activity|lipoyltransferase activity|protein phosphopantetheinylation|cellular nitrogen compound metabolic process" hsa00785 Lipoic acid metabolism LIPT2 57.45437585 54.80762229 60.10112941 1.096583411 0.133015554 0.890406189 1 1.170735015 1.339109863 387787 lipoyl(octanoyl) transferase 2 "GO:0005739,GO:0005759,GO:0009249,GO:0016874,GO:0018215,GO:0033819,GO:0034641,GO:0102555,GO:2000376" mitochondrion|mitochondrial matrix|protein lipoylation|ligase activity|protein phosphopantetheinylation|lipoyl(octanoyl) transferase activity|cellular nitrogen compound metabolic process|octanoyl transferase activity (acting on glycine-cleavage complex H protein)|positive regulation of oxygen metabolic process hsa00785 Lipoic acid metabolism LITAF 2116.092874 2037.016629 2195.16912 1.077639274 0.107874335 0.737788185 1 25.06504035 28.17459931 9516 lipopolysaccharide induced TNF factor "GO:0000139,GO:0000978,GO:0001228,GO:0001817,GO:0005515,GO:0005654,GO:0005765,GO:0005794,GO:0005886,GO:0006357,GO:0007568,GO:0008270,GO:0009898,GO:0043123,GO:0043231,GO:0045944,GO:0050699,GO:0071222,GO:0098559,GO:0098560,GO:0098574,GO:1901223" "Golgi membrane|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|regulation of cytokine production|protein binding|nucleoplasm|lysosomal membrane|Golgi apparatus|plasma membrane|regulation of transcription by RNA polymerase II|aging|zinc ion binding|cytoplasmic side of plasma membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|WW domain binding|cellular response to lipopolysaccharide|cytoplasmic side of early endosome membrane|cytoplasmic side of late endosome membrane|cytoplasmic side of lysosomal membrane|negative regulation of NIK/NF-kappaB signaling" hsa04142 Lysosome LIX1L 1476.917303 1212.872382 1740.962224 1.435404293 0.52145714 0.116819001 1 15.39155786 23.04478972 128077 limb and CNS expressed 1 like "GO:0003674,GO:0005575,GO:0005737,GO:0008150,GO:0097352" molecular_function|cellular_component|cytoplasm|biological_process|autophagosome maturation LLGL1 1799.87842 1906.087309 1693.669532 0.888558213 -0.170461799 0.600571102 1 22.37751458 20.74023456 3996 LLGL scribble cell polarity complex component 1 "GO:0000137,GO:0005096,GO:0005198,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0006887,GO:0006893,GO:0007409,GO:0008593,GO:0019901,GO:0030424,GO:0030864,GO:0030866,GO:0031901,GO:0032588,GO:0032878,GO:0043547,GO:0045159,GO:0050708,GO:0051294,GO:0065003" Golgi cis cisterna|GTPase activator activity|structural molecule activity|protein binding|cytoplasm|cytoskeleton|plasma membrane|exocytosis|Golgi to plasma membrane transport|axonogenesis|regulation of Notch signaling pathway|protein kinase binding|axon|cortical actin cytoskeleton|cortical actin cytoskeleton organization|early endosome membrane|trans-Golgi network membrane|regulation of establishment or maintenance of cell polarity|positive regulation of GTPase activity|myosin II binding|regulation of protein secretion|establishment of spindle orientation|protein-containing complex assembly "hsa04390,hsa04530,hsa05165" Hippo signaling pathway|Tight junction|Human papillomavirus infection LLGL2 105.6256902 81.19647747 130.054903 1.601730851 0.679631743 0.308721119 1 0.656185598 1.096306943 3993 LLGL scribble cell polarity complex component 2 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006887,GO:0008593,GO:0015820,GO:0030165,GO:0030864,GO:0030866,GO:0032878,GO:0043231,GO:0043547,GO:0045159,GO:0050708,GO:0051294,GO:0051301" GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|exocytosis|regulation of Notch signaling pathway|leucine transport|PDZ domain binding|cortical actin cytoskeleton|cortical actin cytoskeleton organization|regulation of establishment or maintenance of cell polarity|intracellular membrane-bounded organelle|positive regulation of GTPase activity|myosin II binding|regulation of protein secretion|establishment of spindle orientation|cell division "hsa04390,hsa04530,hsa05165" Hippo signaling pathway|Tight junction|Human papillomavirus infection LLPH 588.2132509 606.9436691 569.4828328 0.93827955 -0.091910273 0.818528441 1 3.977685775 3.89294845 84298 "LLP homolog, long-term synaptic facilitation factor" "GO:0001099,GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0060999,GO:0097484" basal RNA polymerase II transcription machinery binding|RNA binding|protein binding|chromosome|nucleolus|positive regulation of dendritic spine development|dendrite extension LMAN1 6788.889517 7168.634005 6409.14503 0.894053878 -0.161566321 0.621215499 1 75.26244256 70.18720199 3998 "lectin, mannose binding 1" "GO:0000139,GO:0005515,GO:0005537,GO:0005783,GO:0005789,GO:0005793,GO:0005829,GO:0006457,GO:0006888,GO:0007029,GO:0007030,GO:0007596,GO:0010638,GO:0012507,GO:0016020,GO:0016021,GO:0018279,GO:0030017,GO:0030134,GO:0032527,GO:0033116,GO:0034498,GO:0046872,GO:0048208,GO:0051082,GO:0062023,GO:0070062,GO:1903215" Golgi membrane|protein binding|mannose binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|protein folding|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|Golgi organization|blood coagulation|positive regulation of organelle organization|ER to Golgi transport vesicle membrane|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|sarcomere|COPII-coated ER to Golgi transport vesicle|protein exit from endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment membrane|early endosome to Golgi transport|metal ion binding|COPII vesicle coating|unfolded protein binding|collagen-containing extracellular matrix|extracellular exosome|negative regulation of protein targeting to mitochondrion hsa04141 Protein processing in endoplasmic reticulum LMAN2 3542.197307 3581.779612 3502.615001 0.977897967 -0.032244152 0.920132285 1 112.6036633 114.8581964 10960 "lectin, mannose binding 2" "GO:0000139,GO:0005515,GO:0005537,GO:0005615,GO:0005789,GO:0005793,GO:0005794,GO:0005887,GO:0006888,GO:0006890,GO:0007029,GO:0007030,GO:0009986,GO:0015031,GO:0030134,GO:0030246,GO:0031072,GO:0033116,GO:0046872,GO:0050766,GO:0070062" "Golgi membrane|protein binding|mannose binding|extracellular space|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|integral component of plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|endoplasmic reticulum organization|Golgi organization|cell surface|protein transport|COPII-coated ER to Golgi transport vesicle|carbohydrate binding|heat shock protein binding|endoplasmic reticulum-Golgi intermediate compartment membrane|metal ion binding|positive regulation of phagocytosis|extracellular exosome" hsa04141 Protein processing in endoplasmic reticulum LMAN2L 677.1097351 622.1680086 732.0514615 1.176613795 0.234640856 0.538637133 1 12.47451099 15.30993671 81562 "lectin, mannose binding 2 like" "GO:0000139,GO:0005515,GO:0005537,GO:0005789,GO:0005793,GO:0005794,GO:0006457,GO:0006888,GO:0007029,GO:0007030,GO:0015031,GO:0016021,GO:0030134,GO:0046872" Golgi membrane|protein binding|mannose binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|protein folding|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|Golgi organization|protein transport|integral component of membrane|COPII-coated ER to Golgi transport vesicle|metal ion binding LMBR1 1552.687899 1644.228669 1461.14713 0.888652021 -0.170309497 0.606683607 1 10.07067137 9.334822987 64327 limb development membrane protein 1 "GO:0004888,GO:0005515,GO:0005887,GO:0007165" transmembrane signaling receptor activity|protein binding|integral component of plasma membrane|signal transduction LMBR1L 693.8646733 555.1809147 832.548432 1.499598437 0.584576227 0.122744595 1 7.138348507 11.16576944 55716 limb development membrane protein 1 like "GO:0004888,GO:0005515,GO:0005789,GO:0005886,GO:0005887,GO:0006898,GO:0007165,GO:0016055,GO:0030217,GO:0042098,GO:0060218,GO:0070231,GO:0090090" transmembrane signaling receptor activity|protein binding|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|signal transduction|Wnt signaling pathway|T cell differentiation|T cell proliferation|hematopoietic stem cell differentiation|T cell apoptotic process|negative regulation of canonical Wnt signaling pathway LMBRD1 456.676492 471.9545253 441.3984586 0.935256333 -0.096566265 0.82174041 1 5.669552123 5.530894056 55788 LMBR1 domain containing 1 "GO:0005515,GO:0005765,GO:0005789,GO:0009235,GO:0015420,GO:0015889,GO:0016020,GO:0016021,GO:0016032,GO:0031419,GO:0043231,GO:0061462" protein binding|lysosomal membrane|endoplasmic reticulum membrane|cobalamin metabolic process|ATPase-coupled vitamin B12 transmembrane transporter activity|cobalamin transport|membrane|integral component of membrane|viral process|cobalamin binding|intracellular membrane-bounded organelle|protein localization to lysosome hsa04977 Vitamin digestion and absorption LMBRD2 406.0919971 381.6234441 430.56055 1.128234014 0.174066337 0.690254711 1 2.207387067 2.59772762 92255 LMBR1 domain containing 2 "GO:0005886,GO:0016020,GO:0016021,GO:0071875" plasma membrane|membrane|integral component of membrane|adrenergic receptor signaling pathway LMCD1 48.76786702 33.49354696 64.04218708 1.912075396 0.935139412 0.276428204 1 0.175150232 0.349326602 29995 LIM and cysteine rich domains 1 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0010611,GO:0044267,GO:0070886" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|regulation of cardiac muscle hypertrophy|cellular protein metabolic process|positive regulation of calcineurin-NFAT signaling cascade LMF2 2566.68532 2059.34566 3074.02498 1.492719284 0.577942883 0.070451738 1 33.22669409 51.73461318 91289 lipase maturation factor 2 "GO:0005515,GO:0005789,GO:0016020,GO:0016021,GO:0051604" protein binding|endoplasmic reticulum membrane|membrane|integral component of membrane|protein maturation LMLN 377.2642292 397.8627396 356.6657188 0.896454187 -0.157698238 0.724582677 1 2.816654205 2.633768278 89782 leishmanolysin like peptidase "GO:0004222,GO:0005737,GO:0005811,GO:0005829,GO:0005925,GO:0006508,GO:0007049,GO:0007155,GO:0008233,GO:0016020,GO:0046872,GO:0051301" metalloendopeptidase activity|cytoplasm|lipid droplet|cytosol|focal adhesion|proteolysis|cell cycle|cell adhesion|peptidase activity|membrane|metal ion binding|cell division LMNA 6254.784653 6825.578887 5683.990419 0.832748476 -0.264047286 0.416895873 1 101.7937254 88.42005593 4000 lamin A/C "GO:0005515,GO:0005634,GO:0005635,GO:0005652,GO:0005654,GO:0005829,GO:0005882,GO:0007084,GO:0008285,GO:0016363,GO:0016604,GO:0016607,GO:0030334,GO:0030951,GO:0031965,GO:0034504,GO:0035861,GO:0036498,GO:0071456,GO:0090343,GO:1903243,GO:1990683" protein binding|nucleus|nuclear envelope|nuclear lamina|nucleoplasm|cytosol|intermediate filament|mitotic nuclear envelope reassembly|negative regulation of cell population proliferation|nuclear matrix|nuclear body|nuclear speck|regulation of cell migration|establishment or maintenance of microtubule cytoskeleton polarity|nuclear membrane|protein localization to nucleus|site of double-strand break|IRE1-mediated unfolded protein response|cellular response to hypoxia|positive regulation of cell aging|negative regulation of cardiac muscle hypertrophy in response to stress|DNA double-strand break attachment to nuclear envelope "hsa04210,hsa05410,hsa05412,hsa05414" Apoptosis|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy LMNB1 2080.373453 2356.727759 1804.019147 0.765476258 -0.385570462 0.230464037 1 52.65105732 42.03922993 4001 lamin B1 "GO:0005198,GO:0005515,GO:0005634,GO:0005635,GO:0005637,GO:0005638,GO:0005654,GO:0016020,GO:0016363,GO:0031965,GO:0035722,GO:0043274,GO:1990837" structural molecule activity|protein binding|nucleus|nuclear envelope|nuclear inner membrane|lamin filament|nucleoplasm|membrane|nuclear matrix|nuclear membrane|interleukin-12-mediated signaling pathway|phospholipase binding|sequence-specific double-stranded DNA binding hsa04210 Apoptosis other LMNB2 6992.91917 6736.262762 7249.575577 1.076201424 0.105948121 0.746520013 1 73.62277617 82.64597012 84823 lamin B2 "GO:0003674,GO:0005515,GO:0005637,GO:0005882,GO:0008150,GO:0031965,GO:0042802" molecular_function|protein binding|nuclear inner membrane|intermediate filament|biological_process|nuclear membrane|identical protein binding hsa04210 Apoptosis LMNTD2 53.40939775 47.70293051 59.11586499 1.239250175 0.309467463 0.72433423 1 1.018973068 1.317157243 256329 lamin tail domain containing 2 GO:0005515 protein binding LMO2 14.92742401 10.14955968 19.70528833 1.941491941 0.957165719 0.447619668 1 0.167822198 0.339860684 4005 LIM domain only 2 "GO:0001102,GO:0001221,GO:0003713,GO:0005515,GO:0005654,GO:0005667,GO:0007275,GO:0043425,GO:0045944,GO:0046872,GO:0097067,GO:1902036" RNA polymerase II activating transcription factor binding|transcription coregulator binding|transcription coactivator activity|protein binding|nucleoplasm|transcription regulator complex|multicellular organism development|bHLH transcription factor binding|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to thyroid hormone stimulus|regulation of hematopoietic stem cell differentiation hsa05202 Transcriptional misregulation in cancer other LMO4 544.9615777 479.0592171 610.8639383 1.275132419 0.350647075 0.381303749 1 4.791204448 6.372589158 8543 LIM domain only 4 "GO:0001843,GO:0003281,GO:0005515,GO:0005667,GO:0008134,GO:0021514,GO:0021522,GO:0021527,GO:0030334,GO:0031252,GO:0031333,GO:0033674,GO:0042659,GO:0045944,GO:0046872,GO:0048538,GO:0050865,GO:0090575" neural tube closure|ventricular septum development|protein binding|transcription regulator complex|transcription factor binding|ventral spinal cord interneuron differentiation|spinal cord motor neuron differentiation|spinal cord association neuron differentiation|regulation of cell migration|cell leading edge|negative regulation of protein-containing complex assembly|positive regulation of kinase activity|regulation of cell fate specification|positive regulation of transcription by RNA polymerase II|metal ion binding|thymus development|regulation of cell activation|RNA polymerase II transcription regulator complex LMO7 921.9721909 691.1850145 1152.759367 1.667801447 0.737947545 0.039565495 0.912025044 3.836283028 6.6737651 4008 LIM domain 7 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0005925,GO:0009986,GO:0016324,GO:0016567,GO:0023051,GO:0030155,GO:0043687,GO:0045944,GO:0046872" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nuclear envelope|cytoplasm|cytosol|focal adhesion|cell surface|apical plasma membrane|protein ubiquitination|regulation of signaling|regulation of cell adhesion|post-translational protein modification|positive regulation of transcription by RNA polymerase II|metal ion binding hsa04520 Adherens junction LMOD1 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.02617975 0.053017228 25802 leiomodin 1 "GO:0003779,GO:0005523,GO:0005829,GO:0005856,GO:0005865,GO:0005884,GO:0006936,GO:0007015,GO:0016020,GO:0030016,GO:0030017,GO:0030239,GO:0030838,GO:0045010,GO:0051694" actin binding|tropomyosin binding|cytosol|cytoskeleton|striated muscle thin filament|actin filament|muscle contraction|actin filament organization|membrane|myofibril|sarcomere|myofibril assembly|positive regulation of actin filament polymerization|actin nucleation|pointed-end actin filament capping LMTK2 1313.510384 1424.99818 1202.022588 0.843525701 -0.245496069 0.467365628 1 8.044040426 7.077640406 22853 lemur tyrosine kinase 2 "GO:0001881,GO:0004674,GO:0004714,GO:0004864,GO:0005515,GO:0005524,GO:0005769,GO:0005794,GO:0005829,GO:0005887,GO:0006468,GO:0007169,GO:0007275,GO:0007409,GO:0016021,GO:0018105,GO:0018107,GO:0018108,GO:0030426,GO:0032456,GO:0032515,GO:0033572,GO:0033674,GO:0043025,GO:0043235,GO:0045022,GO:0046777,GO:0048471,GO:0055037,GO:0070853,GO:0106310,GO:0106311" receptor recycling|protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein phosphatase inhibitor activity|protein binding|ATP binding|early endosome|Golgi apparatus|cytosol|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axonogenesis|integral component of membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|growth cone|endocytic recycling|negative regulation of phosphoprotein phosphatase activity|transferrin transport|positive regulation of kinase activity|neuronal cell body|receptor complex|early endosome to late endosome transport|protein autophosphorylation|perinuclear region of cytoplasm|recycling endosome|myosin VI binding|protein serine kinase activity|protein threonine kinase activity LMTK3 29.54036512 32.47859099 26.60213925 0.819066913 -0.287946779 0.798353851 1 0.296489916 0.253305862 114783 lemur tyrosine kinase 3 "GO:0000139,GO:0003674,GO:0004672,GO:0005515,GO:0005524,GO:0005575,GO:0006468,GO:0010923,GO:0016021,GO:0030424,GO:0030425,GO:0046872,GO:0106310,GO:0106311" Golgi membrane|molecular_function|protein kinase activity|protein binding|ATP binding|cellular_component|protein phosphorylation|negative regulation of phosphatase activity|integral component of membrane|axon|dendrite|metal ion binding|protein serine kinase activity|protein threonine kinase activity LNP1 41.09359255 47.70293051 34.48425458 0.722895935 -0.468140116 0.615550377 1 1.296129369 0.977327376 348801 leukemia NUP98 fusion partner 1 LNPEP 2373.059335 1956.835107 2789.283563 1.42540552 0.511372416 0.109899081 1 7.304989671 10.861104 4012 leucyl and cystinyl aminopeptidase "GO:0000209,GO:0002480,GO:0004177,GO:0005515,GO:0005576,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0007165,GO:0007267,GO:0007565,GO:0008217,GO:0008237,GO:0008270,GO:0016020,GO:0031905,GO:0042277,GO:0043171,GO:0070006,GO:0120163" "protein polyubiquitination|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|aminopeptidase activity|protein binding|extracellular region|cytoplasm|lysosomal membrane|cytosol|plasma membrane|integral component of plasma membrane|proteolysis|signal transduction|cell-cell signaling|female pregnancy|regulation of blood pressure|metallopeptidase activity|zinc ion binding|membrane|early endosome lumen|peptide binding|peptide catabolic process|metalloaminopeptidase activity|negative regulation of cold-induced thermogenesis" hsa04614 Renin-angiotensin system LNPK 893.9797459 899.250988 888.7085037 0.988276372 -0.017013547 0.965647432 1 5.35999649 5.525337962 80856 "lunapark, ER junction formation factor" "GO:0005654,GO:0005783,GO:0005789,GO:0007029,GO:0007596,GO:0016021,GO:0030176,GO:0032330,GO:0035115,GO:0042733,GO:0042802,GO:0046872,GO:0060173,GO:0071782,GO:0071786,GO:0071788,GO:0098826,GO:1903373" nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum organization|blood coagulation|integral component of membrane|integral component of endoplasmic reticulum membrane|regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|embryonic digit morphogenesis|identical protein binding|metal ion binding|limb development|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance|endoplasmic reticulum tubular network membrane|positive regulation of endoplasmic reticulum tubular network organization LNX1 13.50891049 14.20938356 12.80843742 0.901406973 -0.149749485 0.969790133 1 0.110818471 0.104195508 84708 ligand of numb-protein X 1 "GO:0004842,GO:0005515,GO:0005737,GO:0006511,GO:0016567,GO:0030165,GO:0042802,GO:0046872" ubiquitin-protein transferase activity|protein binding|cytoplasm|ubiquitin-dependent protein catabolic process|protein ubiquitination|PDZ domain binding|identical protein binding|metal ion binding LNX2 250.7307428 234.4548287 267.0066569 1.138840511 0.187565719 0.713109853 1 2.46457243 2.927658544 222484 ligand of numb-protein X 2 "GO:0005515,GO:0030165,GO:0042802,GO:0046872" protein binding|PDZ domain binding|identical protein binding|metal ion binding LOC100133315 65.03685406 68.00204988 62.07165824 0.912790987 -0.131643548 0.884665846 1 0.64859961 0.617538383 100133315 XRCC1 N-terminal domain containing 1-like "GO:0000012,GO:0003684,GO:0005694,GO:0005730" single strand break repair|damaged DNA binding|chromosome|nucleolus LOC100421372 733.6976127 685.0952787 782.2999467 1.14188489 0.191417224 0.610309025 1 7.445849569 8.868547851 100421372 zinc finger and SCAN domain containing 29 LOC100509620 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.084407125 0.028489143 100509620 putative aquaporin-7-like protein 3 "hsa03320,hsa04923" PPAR signaling pathway|Regulation of lipolysis in adipocytes LOC101060341 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.08870395 0.067363672 101060341 LOC101928764 10.55311724 14.20938356 6.896850916 0.485372985 -1.042834281 0.467996854 1 0.125244544 0.063408919 101928764 coiled-coil domain-containing protein 144B LOC101928841 12.04585964 15.22433953 8.867379749 0.582447582 -0.779799875 0.579059576 1 0.078945335 0.047962217 101928841 collagen alpha-1(II) chain-like LOC101929937 12.00132231 12.17947162 11.823173 0.970745971 -0.042834281 1 1 0.400030656 0.405055749 101929937 LOC101930434 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.081464246 0.164975162 101930434 LOC102723728 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.230510938 0.133375179 102723728 LOC102723750 6.045198483 9.134603715 2.95579325 0.32358199 -1.627796782 0.370626867 1 0.075225277 0.02539008 102723750 LOC102723996 154.9940692 256.78386 53.20427849 0.207194792 -2.270940354 0.000217238 0.030355135 2.373211064 0.512898146 102723996 ICOS ligand "hsa04514,hsa04672" Cell adhesion molecules|Intestinal immune network for IgA production LOC102724159 317.1658214 364.3691926 269.9624501 0.74090361 -0.432642232 0.352586443 1 5.788586634 4.473528186 102724159 periodic tryptophan protein 2 homolog "GO:0000028,GO:0000462,GO:0003723,GO:0005654,GO:0006364,GO:0032040,GO:0034388" "ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|rRNA processing|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome" LOC102724200 25.5102328 26.38885518 24.63161041 0.933409587 -0.09941781 0.964685317 1 0.415191805 0.404237836 102724200 LOC102724250 354.0686997 361.3243247 346.8130746 0.959838712 -0.059136094 0.901452895 1 3.326027331 3.32996758 102724250 LOC102724474 9.030683284 11.16451565 6.896850916 0.617747436 -0.694910978 0.677685443 1 0.434956409 0.28026742 102724474 LOC102724770 7.537940883 10.14955968 4.926322083 0.485372985 -1.042834281 0.538494358 1 0.460196412 0.232988647 102724770 protein DGCR6 "GO:0003674,GO:0005515,GO:0005634,GO:0007155,GO:0009887,GO:0031012" molecular_function|protein binding|nucleus|cell adhesion|animal organ morphogenesis|extracellular matrix LOC102724813 17.86837148 9.134603715 26.60213925 2.912237912 1.542128219 0.188377045 1 0.298474486 0.906671561 102724813 LOC102725191 9.434240837 5.074779842 13.79370183 2.718088717 1.442592546 0.330110601 1 0.128445625 0.364165563 102725191 uncharacterized LOC102725191 LOC105369669 6.552676467 10.14955968 2.95579325 0.291223791 -1.779799875 0.306941875 1 0.541094097 0.164367359 105369669 LOC105371932 4.552456082 8.119647747 0.985264417 0.121343246 -3.042834281 0.175274214 1 0.351179773 0.044448902 105371932 LOC105372704 10.0159477 11.16451565 8.867379749 0.794246703 -0.332340898 0.878848877 1 0.337779768 0.279836902 105372704 LOC105373102-2 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.114740936 0 105373102 LOC105376714 20.19519894 33.49354696 6.896850916 0.205915812 -2.279873479 0.049360307 1 1.730948975 0.371783312 105376714 LOC105377805 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.0504785 0.017037533 105377805 LOC105379554 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.217813302 0.330824134 105379554 LOC105379752 20.01704963 21.31407534 18.72002391 0.878293973 -0.187224191 0.910896573 1 0.132127628 0.12104573 105379752 LOC107984264 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.01871957 0.075818884 107984264 LOC107984449 220.8219549 143.1087915 298.5351182 2.086071128 1.06078835 0.043328174 0.94601832 2.982697709 6.490143252 107984449 LOC107984638 22.55443955 26.38885518 18.72002391 0.709391286 -0.495346486 0.667532794 1 0.964983697 0.714038708 107984638 LOC107984817 10.92698324 6.08973581 15.76423066 2.588655921 1.372203218 0.325525976 1 0.117315951 0.316772392 107984817 LOC107985021 24.52496838 26.38885518 22.66108158 0.85873682 -0.219712043 0.869498585 1 0.134850411 0.120789251 107985021 LOC107985678 22.40598179 16.23929549 28.57266808 1.759477072 0.815146714 0.459784127 1 0.369812513 0.678705147 107985678 LOC107985805 7.552786659 11.16451565 3.941057666 0.352998535 -1.5022659 0.356891946 1 0.469247578 0.172778967 107985805 LOC107986762 5.537720498 8.119647747 2.95579325 0.364029739 -1.457871781 0.448526494 1 0.188465405 0.071562324 107986762 LOC107986982 12.52364607 14.20938356 10.83790858 0.762728977 -0.390757585 0.812815113 1 0.162854752 0.129564675 107986982 LOC107987158 9.956564597 7.104691779 12.80843742 1.802813945 0.850250515 0.576368418 1 0.053378961 0.100377634 107987158 LOC107987269 28.89927515 22.3290313 35.469519 1.588493406 0.667659102 0.514948715 1 0.648816215 1.075036083 107987269 LOC107987372 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.187377664 0.189731459 107987372 LOC107987373 859.022902 1203.737778 514.3080254 0.427259188 -1.226816579 0.000819938 0.080956814 47.07727564 20.98063664 107987373 LOC112267904 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.023238671 0.00784353 112267904 LOC112268052 19.00209366 19.2841634 18.72002391 0.970745971 -0.042834281 1 1 0.770856232 0.78053955 112268052 LOC112268131 11.10513255 18.26920743 3.941057666 0.215721327 -2.212759283 0.116683986 1 0.468017656 0.105310397 112268131 LOC112268444 12.44941719 9.134603715 15.76423066 1.725770614 0.787240717 0.570104177 1 0.114740936 0.206546285 112268444 LOC112694756 51.48340625 50.74779842 52.21901408 1.028990729 0.041229984 0.986980443 1 1.106412812 1.187529994 112694756 uncharaterized LOC112694756 LOC114841035 21.48010047 20.29911937 22.66108158 1.116357866 0.15879958 0.927935429 1 0.62119564 0.723348801 114841035 Uncharacterized protein LOC114841035 LOC389831 816.511042 789.6357434 843.3863406 1.068070117 0.09500636 0.797709717 1 15.43506937 17.195875 389831 uncharacterized LOC389831 LOC389895 30.10722621 37.55337083 22.66108158 0.603436684 -0.728725691 0.468564082 1 1.54128505 0.970131495 389895 chromosome 16 open reading frame 72-like LOC400499 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.01819995 0.003685715 400499 putative uncharacterized protein LOC400499 LOC441155 29.54036512 32.47859099 26.60213925 0.819066913 -0.287946779 0.798353851 1 0.380329724 0.324934317 441155 zinc finger CCCH-type domain-containing-like LOC728392 63.44019123 59.88240213 66.99798033 1.118825864 0.161985511 0.854765414 1 2.021888277 2.359584755 728392 uncharacterized LOC728392 LOC730098 68.17079662 80.1815215 56.16007174 0.70041165 -0.513725015 0.50964606 1 2.05303903 1.499914475 730098 uncharacterized LOC730098 LONP1 2162.46612 2513.030978 1811.901262 0.721002359 -0.471924116 0.14148593 1 37.04195389 27.85777985 9361 "lon peptidase 1, mitochondrial" "GO:0000002,GO:0001018,GO:0001666,GO:0003697,GO:0003727,GO:0004176,GO:0004252,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006515,GO:0007005,GO:0007568,GO:0009725,GO:0010044,GO:0016020,GO:0016887,GO:0032042,GO:0034599,GO:0042645,GO:0042802,GO:0043531,GO:0043565,GO:0051131,GO:0051603,GO:0051880,GO:0070182,GO:0070407" mitochondrial genome maintenance|mitochondrial promoter sequence-specific DNA binding|response to hypoxia|single-stranded DNA binding|single-stranded RNA binding|ATP-dependent peptidase activity|serine-type endopeptidase activity|protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|protein quality control for misfolded or incompletely synthesized proteins|mitochondrion organization|aging|response to hormone|response to aluminum ion|membrane|ATPase activity|mitochondrial DNA metabolic process|cellular response to oxidative stress|mitochondrial nucleoid|identical protein binding|ADP binding|sequence-specific DNA binding|chaperone-mediated protein complex assembly|proteolysis involved in cellular protein catabolic process|G-quadruplex DNA binding|DNA polymerase binding|oxidation-dependent protein catabolic process LONP2 1325.685896 1314.367979 1337.003813 1.017221839 0.024634342 0.944072193 1 6.756125173 7.168516558 83752 "lon peptidase 2, peroxisomal" "GO:0002020,GO:0004176,GO:0004252,GO:0005515,GO:0005524,GO:0005634,GO:0005777,GO:0005782,GO:0005829,GO:0006515,GO:0006625,GO:0007031,GO:0008233,GO:0014070,GO:0016020,GO:0016485,GO:0016558,GO:0019899,GO:0031998" protease binding|ATP-dependent peptidase activity|serine-type endopeptidase activity|protein binding|ATP binding|nucleus|peroxisome|peroxisomal matrix|cytosol|protein quality control for misfolded or incompletely synthesized proteins|protein targeting to peroxisome|peroxisome organization|peptidase activity|response to organic cyclic compound|membrane|protein processing|protein import into peroxisome matrix|enzyme binding|regulation of fatty acid beta-oxidation LONRF1 253.226317 202.9911937 303.4614403 1.494948795 0.58009607 0.245734913 1 2.471343233 3.853677024 91694 LON peptidase N-terminal domain and ring finger 1 "GO:0000209,GO:0005515,GO:0005829,GO:0046872" protein polyubiquitination|protein binding|cytosol|metal ion binding LONRF2 53.91687574 48.71788648 59.11586499 1.213432463 0.279093814 0.751987172 1 0.162993069 0.206300688 164832 LON peptidase N-terminal domain and ring finger 2 "GO:0005515,GO:0046872" protein binding|metal ion binding LONRF3 180.8539197 206.0360616 155.6717778 0.755555977 -0.40438945 0.470238063 1 2.582281531 2.035101922 79836 LON peptidase N-terminal domain and ring finger 3 "GO:0005515,GO:0046872" protein binding|metal ion binding LOX 1922.52974 2814.4729 1030.58658 0.366173922 -1.449399046 1.08E-05 0.002653656 26.90508183 10.27632092 4015 lysyl oxidase "GO:0001649,GO:0001932,GO:0004720,GO:0005507,GO:0005515,GO:0005518,GO:0005576,GO:0005581,GO:0005615,GO:0005634,GO:0006464,GO:0007507,GO:0010468,GO:0016202,GO:0017015,GO:0018057,GO:0018215,GO:0030198,GO:0030199,GO:0030282,GO:0030324,GO:0031012,GO:0035791,GO:0035905,GO:0035906,GO:0042060,GO:0042493,GO:0042981,GO:0043491,GO:0045652,GO:0046716,GO:0048251,GO:0048514,GO:0048545,GO:0048747,GO:0060326,GO:0061448,GO:0071897,GO:1900120,GO:1903010,GO:1990869,GO:2000586" osteoblast differentiation|regulation of protein phosphorylation|protein-lysine 6-oxidase activity|copper ion binding|protein binding|collagen binding|extracellular region|collagen trimer|extracellular space|nucleus|cellular protein modification process|heart development|regulation of gene expression|regulation of striated muscle tissue development|regulation of transforming growth factor beta receptor signaling pathway|peptidyl-lysine oxidation|protein phosphopantetheinylation|extracellular matrix organization|collagen fibril organization|bone mineralization|lung development|extracellular matrix|platelet-derived growth factor receptor-beta signaling pathway|ascending aorta development|descending aorta development|wound healing|response to drug|regulation of apoptotic process|protein kinase B signaling|regulation of megakaryocyte differentiation|muscle cell cellular homeostasis|elastic fiber assembly|blood vessel morphogenesis|response to steroid hormone|muscle fiber development|cell chemotaxis|connective tissue development|DNA biosynthetic process|regulation of receptor binding|regulation of bone development|cellular response to chemokine|regulation of platelet-derived growth factor receptor-beta signaling pathway LOXL1 71.14143565 81.19647747 61.08639383 0.752328127 -0.410566066 0.596107862 1 1.382290803 1.084732487 4016 lysyl oxidase like 1 "GO:0001669,GO:0004720,GO:0005507,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0018057,GO:0018215,GO:0018277,GO:0030198,GO:0030199,GO:0032496,GO:0035904,GO:0055114,GO:0062023" acrosomal vesicle|protein-lysine 6-oxidase activity|copper ion binding|protein binding|extracellular region|basement membrane|extracellular space|peptidyl-lysine oxidation|protein phosphopantetheinylation|protein deamination|extracellular matrix organization|collagen fibril organization|response to lipopolysaccharide|aorta development|oxidation-reduction process|collagen-containing extracellular matrix LOXL2 9887.815329 12306.34112 7469.289542 0.606946408 -0.720358958 0.032869706 0.814471658 167.5014145 106.0436712 4017 lysyl oxidase like 2 "GO:0000122,GO:0000785,GO:0001666,GO:0001837,GO:0001935,GO:0002040,GO:0004720,GO:0005044,GO:0005507,GO:0005509,GO:0005515,GO:0005604,GO:0005615,GO:0005634,GO:0005654,GO:0005783,GO:0006464,GO:0006897,GO:0007155,GO:0007568,GO:0009055,GO:0010718,GO:0016020,GO:0018057,GO:0018215,GO:0022900,GO:0030199,GO:0032332,GO:0043542,GO:0045892,GO:0046688,GO:0062023,GO:0070492,GO:0070828,GO:1902455" "negative regulation of transcription by RNA polymerase II|chromatin|response to hypoxia|epithelial to mesenchymal transition|endothelial cell proliferation|sprouting angiogenesis|protein-lysine 6-oxidase activity|scavenger receptor activity|copper ion binding|calcium ion binding|protein binding|basement membrane|extracellular space|nucleus|nucleoplasm|endoplasmic reticulum|cellular protein modification process|endocytosis|cell adhesion|aging|electron transfer activity|positive regulation of epithelial to mesenchymal transition|membrane|peptidyl-lysine oxidation|protein phosphopantetheinylation|electron transport chain|collagen fibril organization|positive regulation of chondrocyte differentiation|endothelial cell migration|negative regulation of transcription, DNA-templated|response to copper ion|collagen-containing extracellular matrix|oligosaccharide binding|heterochromatin organization|negative regulation of stem cell population maintenance" LOXL3 70.60426611 78.15160956 63.05692266 0.806853794 -0.309620822 0.694870814 1 1.01803069 0.856784588 84695 lysyl oxidase like 3 "GO:0001837,GO:0001968,GO:0004720,GO:0005044,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0006897,GO:0006954,GO:0016020,GO:0018057,GO:0018215,GO:0021510,GO:0030199,GO:0030324,GO:0045892,GO:0060021,GO:0061053,GO:1905590,GO:2000329,GO:2001046" "epithelial to mesenchymal transition|fibronectin binding|protein-lysine 6-oxidase activity|scavenger receptor activity|copper ion binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|endocytosis|inflammatory response|membrane|peptidyl-lysine oxidation|protein phosphopantetheinylation|spinal cord development|collagen fibril organization|lung development|negative regulation of transcription, DNA-templated|roof of mouth development|somite development|fibronectin fibril organization|negative regulation of T-helper 17 cell lineage commitment|positive regulation of integrin-mediated signaling pathway" LOXL4 158.8366497 182.6920743 134.9812251 0.738845544 -0.436655295 0.454976984 1 2.083005192 1.605313806 84171 lysyl oxidase like 4 "GO:0004720,GO:0005044,GO:0005507,GO:0005515,GO:0005615,GO:0006897,GO:0016020,GO:0018057,GO:0018215,GO:0030199,GO:0043235,GO:0070062" protein-lysine 6-oxidase activity|scavenger receptor activity|copper ion binding|protein binding|extracellular space|endocytosis|membrane|peptidyl-lysine oxidation|protein phosphopantetheinylation|collagen fibril organization|receptor complex|extracellular exosome LPAR1 106.0859093 112.6601125 99.51170607 0.883291379 -0.179038665 0.798840812 1 0.863082326 0.795192261 1902 lysophosphatidic acid receptor 1 "GO:0000187,GO:0001965,GO:0004930,GO:0005515,GO:0005737,GO:0005768,GO:0005886,GO:0005887,GO:0007186,GO:0007189,GO:0007193,GO:0007202,GO:0007204,GO:0008360,GO:0009986,GO:0010977,GO:0014003,GO:0019222,GO:0021549,GO:0021554,GO:0022008,GO:0022038,GO:0030139,GO:0030165,GO:0032060,GO:0035025,GO:0035727,GO:0042552,GO:0043025,GO:0043065,GO:0043123,GO:0043197,GO:0043198,GO:0043410,GO:0043951,GO:0051482,GO:0051496,GO:0060326,GO:0060999,GO:0070915,GO:0071453,GO:0071673,GO:1904566" activation of MAPK activity|G-protein alpha-subunit binding|G protein-coupled receptor activity|protein binding|cytoplasm|endosome|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|regulation of cell shape|cell surface|negative regulation of neuron projection development|oligodendrocyte development|regulation of metabolic process|cerebellum development|optic nerve development|neurogenesis|corpus callosum development|endocytic vesicle|PDZ domain binding|bleb assembly|positive regulation of Rho protein signal transduction|lysophosphatidic acid binding|myelination|neuronal cell body|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|dendritic spine|dendritic shaft|positive regulation of MAPK cascade|negative regulation of cAMP-mediated signaling|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of stress fiber assembly|cell chemotaxis|positive regulation of dendritic spine development|lysophosphatidic acid receptor activity|cellular response to oxygen levels|positive regulation of smooth muscle cell chemotaxis|cellular response to 1-oleoyl-sn-glycerol 3-phosphate "hsa04015,hsa04072,hsa04080,hsa04151,hsa04540,hsa04810,hsa05130,hsa05200" Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Gap junction|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Pathways in cancer LPAR2 211.78855 165.4378228 258.1392771 1.560340149 0.641860566 0.225624798 1 3.551861847 5.78084438 9170 lysophosphatidic acid receptor 2 "GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007189,GO:0007202,GO:0007204,GO:0008289,GO:0009986,GO:0019222,GO:0030139,GO:0070915" G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|lipid binding|cell surface|regulation of metabolic process|endocytic vesicle|lysophosphatidic acid receptor activity "hsa04015,hsa04072,hsa04080,hsa04151,hsa04810,hsa05130,hsa05200" Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Pathways in cancer LPAR3 201.9237817 130.9293199 272.9182434 2.08447003 1.059680629 0.049879386 1 1.549686413 3.369422025 23566 lysophosphatidic acid receptor 3 "GO:0000187,GO:0001965,GO:0004930,GO:0005515,GO:0005543,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007189,GO:0007204,GO:0007268,GO:0008289,GO:0019222,GO:0030424,GO:0032060,GO:0045202,GO:0048672,GO:0051482,GO:0051928,GO:0070915" "activation of MAPK activity|G-protein alpha-subunit binding|G protein-coupled receptor activity|protein binding|phospholipid binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|lipid binding|regulation of metabolic process|axon|bleb assembly|synapse|positive regulation of collateral sprouting|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of calcium ion transport|lysophosphatidic acid receptor activity" "hsa04015,hsa04072,hsa04080,hsa04151,hsa05200" Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Pathways in cancer LPAR5 45.43820777 41.6131947 49.26322083 1.183836549 0.243469904 0.800416155 1 0.766943781 0.947046283 57121 lysophosphatidic acid receptor 5 "GO:0003674,GO:0004930,GO:0005575,GO:0005886,GO:0007186,GO:0008150,GO:0016021,GO:0032793,GO:0048266" molecular_function|G protein-coupled receptor activity|cellular_component|plasma membrane|G protein-coupled receptor signaling pathway|biological_process|integral component of membrane|positive regulation of CREB transcription factor activity|behavioral response to pain "hsa04015,hsa04072,hsa04151,hsa04810,hsa05130,hsa05200" Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Pathways in cancer LPAR6 10.53827146 13.19442759 7.882115332 0.597382136 -0.743273999 0.622951235 1 0.17161048 0.106933053 10161 lysophosphatidic acid receptor 6 "GO:0001835,GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0035025,GO:0051482,GO:0070915" blastocyst hatching|G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|positive regulation of Rho protein signal transduction|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|lysophosphatidic acid receptor activity "hsa04072,hsa04080,hsa04151,hsa05200" Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Pathways in cancer LPCAT1 3095.487773 3723.873448 2467.102099 0.662509651 -0.593986624 0.062422446 1 39.68042354 27.42107257 79888 lysophosphatidylcholine acyltransferase 1 "GO:0000139,GO:0003841,GO:0005509,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0005886,GO:0006654,GO:0006656,GO:0008654,GO:0016020,GO:0016021,GO:0035577,GO:0036148,GO:0036151,GO:0043129,GO:0043312,GO:0045732,GO:0047159,GO:0047184,GO:0047191,GO:0047192,GO:0050200,GO:0060041,GO:2001246" Golgi membrane|1-acylglycerol-3-phosphate O-acyltransferase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|plasma membrane|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phospholipid biosynthetic process|membrane|integral component of membrane|azurophil granule membrane|phosphatidylglycerol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|surfactant homeostasis|neutrophil degranulation|positive regulation of protein catabolic process|1-alkenylglycerophosphocholine O-acyltransferase activity|1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|plasmalogen synthase activity|retina development in camera-type eye|negative regulation of phosphatidylcholine biosynthetic process "hsa00564,hsa00565" Glycerophospholipid metabolism|Ether lipid metabolism LPCAT3 738.3958049 736.858033 739.9335768 1.004173862 0.006009078 0.991283291 1 16.69765543 17.48961854 10162 lysophosphatidylcholine acyltransferase 3 "GO:0005789,GO:0006656,GO:0016020,GO:0016021,GO:0016746,GO:0030258,GO:0034378,GO:0034379,GO:0036150,GO:0036151,GO:0036152,GO:0036335,GO:0045540,GO:0045797,GO:0047184,GO:0050728,GO:0071617,GO:0090158,GO:0106262,GO:0106263,GO:1901310,GO:1903573,GO:1905885" "endoplasmic reticulum membrane|phosphatidylcholine biosynthetic process|membrane|integral component of membrane|transferase activity, transferring acyl groups|lipid modification|chylomicron assembly|very-low-density lipoprotein particle assembly|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|intestinal stem cell homeostasis|regulation of cholesterol biosynthetic process|positive regulation of intestinal cholesterol absorption|1-acylglycerophosphocholine O-acyltransferase activity|negative regulation of inflammatory response|lysophospholipid acyltransferase activity|endoplasmic reticulum membrane organization|1-acylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphoserine O-acyltransferase activity|positive regulation of sterol regulatory element binding protein cleavage|negative regulation of response to endoplasmic reticulum stress|positive regulation of triglyceride transport" "hsa00564,hsa04216" Glycerophospholipid metabolism|Ferroptosis LPCAT4 833.5062343 705.394398 961.6180705 1.363234629 0.447033889 0.220091255 1 15.53292947 22.08716164 254531 lysophosphatidylcholine acyltransferase 4 "GO:0005783,GO:0005789,GO:0006644,GO:0006654,GO:0016020,GO:0016021,GO:0036148,GO:0036150,GO:0036151,GO:0036152,GO:0047166,GO:0047184,GO:0047192,GO:0071617,GO:0106262,GO:0106263" endoplasmic reticulum|endoplasmic reticulum membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|membrane|integral component of membrane|phosphatidylglycerol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|1-alkenylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|lysophospholipid acyltransferase activity|1-acylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphoserine O-acyltransferase activity "hsa00564,hsa00565" Glycerophospholipid metabolism|Ether lipid metabolism LPGAT1 2313.125469 2102.988766 2523.262171 1.199845768 0.262848969 0.411215029 1 10.89605751 13.63674565 9926 lysophosphatidylglycerol acyltransferase 1 "GO:0003846,GO:0005737,GO:0005783,GO:0005789,GO:0008654,GO:0012505,GO:0016020,GO:0016021,GO:0016746,GO:0019432,GO:0036148,GO:0036149,GO:0045723,GO:0071617" "2-acylglycerol O-acyltransferase activity|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|phospholipid biosynthetic process|endomembrane system|membrane|integral component of membrane|transferase activity, transferring acyl groups|triglyceride biosynthetic process|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|positive regulation of fatty acid biosynthetic process|lysophospholipid acyltransferase activity" hsa00564 Glycerophospholipid metabolism LPIN1 441.4966898 444.5507141 438.4426654 0.986260176 -0.019959815 0.968159819 1 3.277758828 3.371975593 23175 lipin 1 "GO:0003713,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005741,GO:0005789,GO:0005829,GO:0006642,GO:0006646,GO:0006656,GO:0007077,GO:0008195,GO:0009062,GO:0016311,GO:0019432,GO:0031100,GO:0031965,GO:0032869,GO:0044255,GO:0045944,GO:0120162" transcription coactivator activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|triglyceride mobilization|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|mitotic nuclear envelope disassembly|phosphatidate phosphatase activity|fatty acid catabolic process|dephosphorylation|triglyceride biosynthetic process|animal organ regeneration|nuclear membrane|cellular response to insulin stimulus|cellular lipid metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of cold-induced thermogenesis "hsa00561,hsa00564,hsa04150" Glycerolipid metabolism|Glycerophospholipid metabolism|mTOR signaling pathway LPIN2 1545.841029 1580.286443 1511.395615 0.956406114 -0.064304743 0.847300786 1 11.89771568 11.86921126 9663 lipin 2 "GO:0003713,GO:0005634,GO:0005789,GO:0005829,GO:0006629,GO:0006646,GO:0006656,GO:0008195,GO:0009062,GO:0016311,GO:0019432,GO:0032869,GO:0044255,GO:0045944" transcription coactivator activity|nucleus|endoplasmic reticulum membrane|cytosol|lipid metabolic process|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidate phosphatase activity|fatty acid catabolic process|dephosphorylation|triglyceride biosynthetic process|cellular response to insulin stimulus|cellular lipid metabolic process|positive regulation of transcription by RNA polymerase II "hsa00561,hsa00564,hsa04150" Glycerolipid metabolism|Glycerophospholipid metabolism|mTOR signaling pathway LPIN3 1188.295696 1014.955968 1361.635424 1.341570931 0.423923334 0.216073191 1 10.06933188 14.09062395 64900 lipin 3 "GO:0003713,GO:0005634,GO:0005789,GO:0006646,GO:0006656,GO:0008195,GO:0009062,GO:0016311,GO:0019432,GO:0032869,GO:0044255,GO:0045944" transcription coactivator activity|nucleus|endoplasmic reticulum membrane|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidate phosphatase activity|fatty acid catabolic process|dephosphorylation|triglyceride biosynthetic process|cellular response to insulin stimulus|cellular lipid metabolic process|positive regulation of transcription by RNA polymerase II "hsa00561,hsa00564,hsa04150" Glycerolipid metabolism|Glycerophospholipid metabolism|mTOR signaling pathway LPP 2899.472357 2346.578199 3452.366516 1.471234377 0.557027096 0.080613814 1 5.020526679 7.704546368 4026 LIM domain containing preferred translocation partner in lipoma "GO:0001725,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005925,GO:0008150,GO:0046872,GO:0098609" stress fiber|protein binding|nucleus|cytosol|plasma membrane|focal adhesion|biological_process|metal ion binding|cell-cell adhesion LPXN 110.8758978 137.0190557 84.73273982 0.618401137 -0.693385124 0.290847996 1 1.462801813 0.94356473 9404 leupaxin "GO:0002102,GO:0003712,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006355,GO:0007155,GO:0007162,GO:0007165,GO:0007179,GO:0016020,GO:0016607,GO:0033628,GO:0034446,GO:0042995,GO:0043542,GO:0046872,GO:0048471,GO:0050859,GO:0065003" "podosome|transcription coregulator activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|regulation of transcription, DNA-templated|cell adhesion|negative regulation of cell adhesion|signal transduction|transforming growth factor beta receptor signaling pathway|membrane|nuclear speck|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading|cell projection|endothelial cell migration|metal ion binding|perinuclear region of cytoplasm|negative regulation of B cell receptor signaling pathway|protein-containing complex assembly" LRATD2 120.4640396 85.25630134 155.6717778 1.825926945 0.868629044 0.17384946 1 0.781950543 1.489287734 157638 LRAT domain containing 2 "GO:0005515,GO:0005737,GO:0005886" protein binding|cytoplasm|plasma membrane LRBA 2272.490611 2288.725709 2256.255514 0.985812981 -0.020614116 0.950070959 1 9.608412053 9.880116867 987 LPS responsive beige-like anchor protein "GO:0003674,GO:0005764,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0019901" molecular_function|lysosome|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|protein localization|biological_process|membrane|integral component of membrane|protein kinase binding LRCH1 665.5416618 605.9287131 725.1546106 1.196765552 0.259140554 0.498436101 1 3.802273787 4.746444367 23143 leucine rich repeats and calponin homology domain containing 1 "GO:0005515,GO:0005737,GO:0034260,GO:1990869,GO:2000405" protein binding|cytoplasm|negative regulation of GTPase activity|cellular response to chemokine|negative regulation of T cell migration LRCH2 514.0511957 588.6744617 439.4279298 0.746470177 -0.421843471 0.298817614 1 4.807980126 3.743613935 57631 leucine rich repeats and calponin homology domain containing 2 GO:0005515 protein binding LRCH3 1595.186643 1484.880582 1705.492705 1.1485723 0.199841674 0.544239903 1 6.235817838 7.47080994 84859 leucine rich repeats and calponin homology domain containing 3 "GO:0005515,GO:0005737,GO:0005829,GO:0032185" protein binding|cytoplasm|cytosol|septin cytoskeleton organization LRCH4 299.0950523 274.0381115 324.151993 1.182871942 0.242293895 0.611991004 1 4.368606735 5.390097375 4034 leucine rich repeats and calponin homology domain containing 4 "GO:0005515,GO:0007399,GO:0016605" protein binding|nervous system development|PML body LRFN1 59.79604908 80.1815215 39.41057666 0.491516947 -1.024686935 0.20280118 1 1.077450571 0.552397598 57622 leucine rich repeat and fibronectin type III domain containing 1 "GO:0005886,GO:0009986,GO:0099061,GO:0099151" plasma membrane|cell surface|integral component of postsynaptic density membrane|regulation of postsynaptic density assembly LRFN3 388.2357498 406.9973433 369.4741562 0.907804835 -0.139545922 0.753842042 1 4.395091607 4.161753495 79414 leucine rich repeat and fibronectin type III domain containing 3 "GO:0005886,GO:0009986,GO:0030424,GO:0030425,GO:0098978,GO:0099059,GO:0099061,GO:0099179,GO:0099560,GO:1905606" plasma membrane|cell surface|axon|dendrite|glutamatergic synapse|integral component of presynaptic active zone membrane|integral component of postsynaptic density membrane|regulation of synaptic membrane adhesion|synaptic membrane adhesion|regulation of presynapse assembly LRFN4 1115.861194 1047.434559 1184.287829 1.130655675 0.177159644 0.609691875 1 21.82182859 25.735786 78999 leucine rich repeat and fibronectin type III domain containing 4 "GO:0005515,GO:0005886,GO:0009986,GO:0098978,GO:0098982,GO:0099061,GO:0099151,GO:0099560,GO:1905606" protein binding|plasma membrane|cell surface|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic density membrane|regulation of postsynaptic density assembly|synaptic membrane adhesion|regulation of presynapse assembly LRGUK 14.52386645 16.23929549 12.80843742 0.788731101 -0.342394563 0.827932218 1 0.039973902 0.032886786 136332 leucine rich repeats and guanylate kinase domain containing "GO:0001669,GO:0002177,GO:0004385,GO:0005515,GO:0005524,GO:0005829,GO:0007283,GO:0016310,GO:0030154,GO:0035082,GO:0042995,GO:0046037,GO:0046710" acrosomal vesicle|manchette|guanylate kinase activity|protein binding|ATP binding|cytosol|spermatogenesis|phosphorylation|cell differentiation|axoneme assembly|cell projection|GMP metabolic process|GDP metabolic process LRIF1 480.8924206 443.5357582 518.2490831 1.168449383 0.224595239 0.588358713 1 5.931745828 7.229501745 55791 ligand dependent nuclear receptor interacting factor 1 "GO:0000781,GO:0001740,GO:0005515,GO:0005654,GO:0006355,GO:0009048,GO:0016363,GO:0034451,GO:0042974" "chromosome, telomeric region|Barr body|protein binding|nucleoplasm|regulation of transcription, DNA-templated|dosage compensation by inactivation of X chromosome|nuclear matrix|centriolar satellite|retinoic acid receptor binding" LRIG1 1261.942108 1132.690861 1391.193356 1.228219812 0.29656878 0.382556132 1 10.24956159 13.13098538 26018 leucine rich repeats and immunoglobulin like domains 1 "GO:0005515,GO:0005615,GO:0005886,GO:0007605,GO:0016021,GO:0022405,GO:0031012,GO:0032474,GO:0060384" protein binding|extracellular space|plasma membrane|sensory perception of sound|integral component of membrane|hair cycle process|extracellular matrix|otolith morphogenesis|innervation LRIG2 701.2553942 723.6636055 678.847183 0.938070089 -0.092232375 0.81002182 1 3.026757675 2.961616838 9860 leucine rich repeats and immunoglobulin like domains 2 "GO:0005102,GO:0005515,GO:0005615,GO:0005737,GO:0005886,GO:0007605,GO:0010640,GO:0016021,GO:0030426,GO:0031012,GO:0043025,GO:0048681,GO:0051045,GO:0060384,GO:0097708,GO:2000010,GO:2001222" signaling receptor binding|protein binding|extracellular space|cytoplasm|plasma membrane|sensory perception of sound|regulation of platelet-derived growth factor receptor signaling pathway|integral component of membrane|growth cone|extracellular matrix|neuronal cell body|negative regulation of axon regeneration|negative regulation of membrane protein ectodomain proteolysis|innervation|intracellular vesicle|positive regulation of protein localization to cell surface|regulation of neuron migration hsa04360 Axon guidance LRIG3 421.3257392 480.074173 362.5773053 0.755252679 -0.404968699 0.343895357 1 5.595871868 4.408348963 121227 leucine rich repeats and immunoglobulin like domains 3 "GO:0005515,GO:0005615,GO:0005886,GO:0016021,GO:0030659,GO:0031012,GO:0032474" protein binding|extracellular space|plasma membrane|integral component of membrane|cytoplasmic vesicle membrane|extracellular matrix|otolith morphogenesis LRMDA 38.93006863 34.50850292 43.35163433 1.256259491 0.329134496 0.738121073 1 0.445396008 0.583635373 83938 leucine rich melanocyte differentiation associated GO:0030318 melanocyte differentiation LRP1 12655.81822 12771.19095 12540.44549 0.981932346 -0.026304467 0.939254588 1 42.96066469 44.001602 4035 LDL receptor related protein 1 "GO:0001523,GO:0001540,GO:0002020,GO:0002265,GO:0003723,GO:0005041,GO:0005044,GO:0005509,GO:0005515,GO:0005634,GO:0005765,GO:0005769,GO:0005856,GO:0005886,GO:0005887,GO:0005905,GO:0005925,GO:0006629,GO:0006898,GO:0006909,GO:0007041,GO:0007204,GO:0007205,GO:0007568,GO:0008283,GO:0010715,GO:0010875,GO:0010942,GO:0010977,GO:0014912,GO:0015026,GO:0016020,GO:0016323,GO:0016964,GO:0021987,GO:0030136,GO:0030178,GO:0030226,GO:0030425,GO:0030666,GO:0031623,GO:0032050,GO:0032092,GO:0032370,GO:0032374,GO:0032429,GO:0032593,GO:0032956,GO:0034185,GO:0035774,GO:0035909,GO:0038023,GO:0038024,GO:0042157,GO:0042953,GO:0043025,GO:0043235,GO:0043277,GO:0043395,GO:0043524,GO:0044242,GO:0044295,GO:0044877,GO:0045056,GO:0045177,GO:0045807,GO:0048691,GO:0048694,GO:0050766,GO:0051481,GO:0051895,GO:0061642,GO:0070325,GO:0070374,GO:0097242,GO:0098797,GO:0150051,GO:0150093,GO:0150094,GO:0150104,GO:1900149,GO:1900223,GO:1903078,GO:1904109,GO:1904300,GO:1904646,GO:1904754,GO:1905049,GO:1905167,GO:2000343,GO:2000587" retinoid metabolic process|amyloid-beta binding|protease binding|astrocyte activation involved in immune response|RNA binding|low-density lipoprotein particle receptor activity|scavenger receptor activity|calcium ion binding|protein binding|nucleus|lysosomal membrane|early endosome|cytoskeleton|plasma membrane|integral component of plasma membrane|clathrin-coated pit|focal adhesion|lipid metabolic process|receptor-mediated endocytosis|phagocytosis|lysosomal transport|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G protein-coupled receptor signaling pathway|aging|cell population proliferation|regulation of extracellular matrix disassembly|positive regulation of cholesterol efflux|positive regulation of cell death|negative regulation of neuron projection development|negative regulation of smooth muscle cell migration|coreceptor activity|membrane|basolateral plasma membrane|alpha-2 macroglobulin receptor activity|cerebral cortex development|clathrin-coated vesicle|negative regulation of Wnt signaling pathway|apolipoprotein receptor activity|dendrite|endocytic vesicle membrane|receptor internalization|clathrin heavy chain binding|positive regulation of protein binding|positive regulation of lipid transport|regulation of cholesterol transport|regulation of phospholipase A2 activity|insulin-responsive compartment|regulation of actin cytoskeleton organization|apolipoprotein binding|positive regulation of insulin secretion involved in cellular response to glucose stimulus|aorta morphogenesis|signaling receptor activity|cargo receptor activity|lipoprotein metabolic process|lipoprotein transport|neuronal cell body|receptor complex|apoptotic cell clearance|heparan sulfate proteoglycan binding|negative regulation of neuron apoptotic process|cellular lipid catabolic process|axonal growth cone|protein-containing complex binding|transcytosis|apical part of cell|positive regulation of endocytosis|positive regulation of axon extension involved in regeneration|positive regulation of collateral sprouting of injured axon|positive regulation of phagocytosis|negative regulation of cytosolic calcium ion concentration|negative regulation of focal adhesion assembly|chemoattraction of axon|lipoprotein particle receptor binding|positive regulation of ERK1 and ERK2 cascade|amyloid-beta clearance|plasma membrane protein complex|postsynaptic Golgi apparatus|amyloid-beta clearance by transcytosis|amyloid-beta clearance by cellular catabolic process|transport across blood-brain barrier|positive regulation of Schwann cell migration|positive regulation of amyloid-beta clearance|positive regulation of protein localization to plasma membrane|positive regulation of cholesterol import|positive regulation of transcytosis|cellular response to amyloid-beta|positive regulation of vascular associated smooth muscle cell migration|negative regulation of metallopeptidase activity|positive regulation of lysosomal protein catabolic process|positive regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of platelet-derived growth factor receptor-beta signaling pathway "hsa04979,hsa05010,hsa05144" Cholesterol metabolism|Alzheimer disease|Malaria LRP10 5121.287915 4740.859328 5501.716502 1.160489296 0.214733215 0.504253935 1 49.0216007 59.33959211 26020 LDL receptor related protein 10 "GO:0005041,GO:0005515,GO:0005905,GO:0006629,GO:0006869,GO:0006897,GO:0016020,GO:0016021,GO:0048839" low-density lipoprotein particle receptor activity|protein binding|clathrin-coated pit|lipid metabolic process|lipid transport|endocytosis|membrane|integral component of membrane|inner ear development LRP11 798.8383872 760.2020203 837.4747541 1.10164763 0.139662841 0.705946215 1 6.567988826 7.547290029 84918 LDL receptor related protein 11 "GO:0005886,GO:0016021,GO:0051219" plasma membrane|integral component of membrane|phosphoprotein binding LRP12 1532.678768 1892.892881 1172.464656 0.619403595 -0.691048338 0.037129163 0.873695618 21.89774936 14.14780717 29967 LDL receptor related protein 12 "GO:0001764,GO:0005041,GO:0005515,GO:0005887,GO:0005905,GO:0006897,GO:0007165,GO:0016021,GO:0031175,GO:0040008" neuron migration|low-density lipoprotein particle receptor activity|protein binding|integral component of plasma membrane|clathrin-coated pit|endocytosis|signal transduction|integral component of membrane|neuron projection development|regulation of growth LRP1B 29.88453957 22.3290313 37.44004783 1.67674304 0.745661614 0.459349322 1 0.052636103 0.092058982 53353 LDL receptor related protein 1B "GO:0005041,GO:0005509,GO:0005515,GO:0005886,GO:0006898,GO:0015031,GO:0016021,GO:0043235" low-density lipoprotein particle receptor activity|calcium ion binding|protein binding|plasma membrane|receptor-mediated endocytosis|protein transport|integral component of membrane|receptor complex LRP2 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.00978129 0 4036 LDL receptor related protein 2 "GO:0001523,GO:0001822,GO:0001843,GO:0003139,GO:0003148,GO:0003223,GO:0003281,GO:0005509,GO:0005515,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005886,GO:0005905,GO:0006629,GO:0006897,GO:0006898,GO:0007605,GO:0008283,GO:0008584,GO:0009897,GO:0015031,GO:0016021,GO:0016324,GO:0017124,GO:0030001,GO:0030139,GO:0030424,GO:0030425,GO:0030514,GO:0030665,GO:0030900,GO:0031526,GO:0031904,GO:0031994,GO:0035904,GO:0042359,GO:0042562,GO:0043066,GO:0043235,GO:0044321,GO:0045056,GO:0050769,GO:0051087,GO:0051897,GO:0060068,GO:0060982,GO:0061024,GO:0061156,GO:0070062,GO:0070447,GO:0071363,GO:0097242,GO:0140058,GO:0140318,GO:0150104,GO:1904447,GO:1905167" retinoid metabolic process|kidney development|neural tube closure|secondary heart field specification|outflow tract septum morphogenesis|ventricular compact myocardium morphogenesis|ventricular septum development|calcium ion binding|protein binding|lysosome|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|clathrin-coated pit|lipid metabolic process|endocytosis|receptor-mediated endocytosis|sensory perception of sound|cell population proliferation|male gonad development|external side of plasma membrane|protein transport|integral component of membrane|apical plasma membrane|SH3 domain binding|metal ion transport|endocytic vesicle|axon|dendrite|negative regulation of BMP signaling pathway|clathrin-coated vesicle membrane|forebrain development|brush border membrane|endosome lumen|insulin-like growth factor I binding|aorta development|vitamin D metabolic process|hormone binding|negative regulation of apoptotic process|receptor complex|response to leptin|transcytosis|positive regulation of neurogenesis|chaperone binding|positive regulation of protein kinase B signaling|vagina development|coronary artery morphogenesis|membrane organization|pulmonary artery morphogenesis|extracellular exosome|positive regulation of oligodendrocyte progenitor proliferation|cellular response to growth factor stimulus|amyloid-beta clearance|neuron projection arborization|protein transporter activity|transport across blood-brain barrier|folate import across plasma membrane|positive regulation of lysosomal protein catabolic process "hsa04340,hsa04918,hsa04979" Hedgehog signaling pathway|Thyroid hormone synthesis|Cholesterol metabolism LRP2BP 11.06059522 15.22433953 6.896850916 0.453014786 -1.142369955 0.413620951 1 0.075475635 0.035664413 55805 LRP2 binding protein "GO:0005515,GO:0005737" protein binding|cytoplasm LRP3 536.1414568 448.610538 623.6723757 1.39023122 0.475324849 0.236811 1 5.537543541 8.030084603 4037 LDL receptor related protein 3 "GO:0005905,GO:0006898,GO:0010628,GO:0010629,GO:0016021,GO:0045599,GO:0045669,GO:0150104" clathrin-coated pit|receptor-mediated endocytosis|positive regulation of gene expression|negative regulation of gene expression|integral component of membrane|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|transport across blood-brain barrier LRP4 667.8427571 763.2468882 572.438626 0.750004533 -0.41502878 0.276932199 1 3.737383962 2.923799151 4038 LDL receptor related protein 4 "GO:0001822,GO:0001942,GO:0005509,GO:0005515,GO:0005886,GO:0006897,GO:0009953,GO:0009954,GO:0009986,GO:0014069,GO:0016021,GO:0016055,GO:0030279,GO:0030425,GO:0030971,GO:0031594,GO:0034185,GO:0042475,GO:0042733,GO:0042803,GO:0043025,GO:0044853,GO:0048813,GO:0050731,GO:0050771,GO:0050808,GO:0051124,GO:0060173,GO:0071340,GO:0090090,GO:0097060,GO:0097104,GO:0097105,GO:0097110,GO:0150094,GO:1901631,GO:1904395" kidney development|hair follicle development|calcium ion binding|protein binding|plasma membrane|endocytosis|dorsal/ventral pattern formation|proximal/distal pattern formation|cell surface|postsynaptic density|integral component of membrane|Wnt signaling pathway|negative regulation of ossification|dendrite|receptor tyrosine kinase binding|neuromuscular junction|apolipoprotein binding|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|protein homodimerization activity|neuronal cell body|plasma membrane raft|dendrite morphogenesis|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of axonogenesis|synapse organization|synaptic growth at neuromuscular junction|limb development|skeletal muscle acetylcholine-gated channel clustering|negative regulation of canonical Wnt signaling pathway|synaptic membrane|postsynaptic membrane assembly|presynaptic membrane assembly|scaffold protein binding|amyloid-beta clearance by cellular catabolic process|positive regulation of presynaptic membrane organization|positive regulation of skeletal muscle acetylcholine-gated channel clustering LRP5 1815.40784 1856.354466 1774.461214 0.955884906 -0.065091175 0.842555294 1 16.13762528 16.09018955 4041 LDL receptor related protein 5 "GO:0001702,GO:0002053,GO:0002076,GO:0005515,GO:0005783,GO:0005886,GO:0006007,GO:0006897,GO:0008203,GO:0008217,GO:0008284,GO:0009314,GO:0009952,GO:0015026,GO:0016021,GO:0017147,GO:0019534,GO:0033690,GO:0035019,GO:0035426,GO:0042074,GO:0042632,GO:0042733,GO:0042813,GO:0042981,GO:0043235,GO:0043434,GO:0045600,GO:0045668,GO:0045669,GO:0045840,GO:0045893,GO:0045944,GO:0046849,GO:0048539,GO:0051091,GO:0060033,GO:0060042,GO:0060070,GO:0060349,GO:0060444,GO:0060612,GO:0060764,GO:0061178,GO:0061304,GO:0071901,GO:0071936,GO:0110135,GO:1901998,GO:1902262,GO:1904928,GO:1990851,GO:1990909" "gastrulation with mouth forming second|positive regulation of mesenchymal cell proliferation|osteoblast development|protein binding|endoplasmic reticulum|plasma membrane|glucose catabolic process|endocytosis|cholesterol metabolic process|regulation of blood pressure|positive regulation of cell population proliferation|response to radiation|anterior/posterior pattern specification|coreceptor activity|integral component of membrane|Wnt-protein binding|toxin transmembrane transporter activity|positive regulation of osteoblast proliferation|somatic stem cell population maintenance|extracellular matrix-cell signaling|cell migration involved in gastrulation|cholesterol homeostasis|embryonic digit morphogenesis|Wnt-activated receptor activity|regulation of apoptotic process|receptor complex|response to peptide hormone|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of osteoblast differentiation|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|bone remodeling|bone marrow development|positive regulation of DNA-binding transcription factor activity|anatomical structure regression|retina morphogenesis in camera-type eye|canonical Wnt signaling pathway|bone morphogenesis|branching involved in mammary gland duct morphogenesis|adipose tissue development|cell-cell signaling involved in mammary gland development|regulation of insulin secretion involved in cellular response to glucose stimulus|retinal blood vessel morphogenesis|negative regulation of protein serine/threonine kinase activity|coreceptor activity involved in Wnt signaling pathway|Norrin signaling pathway|toxin transport|apoptotic process involved in blood vessel morphogenesis|coreceptor activity involved in canonical Wnt signaling pathway|Wnt-Frizzled-LRP5/6 complex|Wnt signalosome" "hsa04150,hsa04310,hsa04928,hsa05010,hsa05022,hsa05200,hsa05224,hsa05225,hsa05226" "mTOR signaling pathway|Wnt signaling pathway|Parathyroid hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" LRP6 1480.87692 1719.33541 1242.418429 0.722615507 -0.46869988 0.158340262 1 9.269562815 6.986866716 4040 LDL receptor related protein 6 "GO:0001843,GO:0001933,GO:0003344,GO:0005041,GO:0005102,GO:0005109,GO:0005515,GO:0005576,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005901,GO:0006469,GO:0007204,GO:0007268,GO:0009880,GO:0009986,GO:0014029,GO:0014033,GO:0015026,GO:0016021,GO:0016055,GO:0017147,GO:0019210,GO:0019534,GO:0021587,GO:0021794,GO:0021987,GO:0030278,GO:0030326,GO:0030901,GO:0030917,GO:0031410,GO:0031901,GO:0034185,GO:0034392,GO:0035261,GO:0042475,GO:0042802,GO:0042803,GO:0042813,GO:0043025,GO:0043434,GO:0044335,GO:0044340,GO:0045202,GO:0045787,GO:0045893,GO:0045944,GO:0046849,GO:0048596,GO:0051091,GO:0060021,GO:0060026,GO:0060059,GO:0060070,GO:0060325,GO:0060349,GO:0060444,GO:0060535,GO:0071397,GO:0071542,GO:0071901,GO:0071936,GO:0072659,GO:0090009,GO:0090090,GO:0090118,GO:0090244,GO:0090245,GO:0098609,GO:1901998,GO:1904886,GO:1904928,GO:1904948,GO:1904953,GO:1990851,GO:1990909" "neural tube closure|negative regulation of protein phosphorylation|pericardium morphogenesis|low-density lipoprotein particle receptor activity|signaling receptor binding|frizzled binding|protein binding|extracellular region|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|caveola|negative regulation of protein kinase activity|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|embryonic pattern specification|cell surface|neural crest formation|neural crest cell differentiation|coreceptor activity|integral component of membrane|Wnt signaling pathway|Wnt-protein binding|kinase inhibitor activity|toxin transmembrane transporter activity|cerebellum morphogenesis|thalamus development|cerebral cortex development|regulation of ossification|embryonic limb morphogenesis|midbrain development|midbrain-hindbrain boundary development|cytoplasmic vesicle|early endosome membrane|apolipoprotein binding|negative regulation of smooth muscle cell apoptotic process|external genitalia morphogenesis|odontogenesis of dentin-containing tooth|identical protein binding|protein homodimerization activity|Wnt-activated receptor activity|neuronal cell body|response to peptide hormone|canonical Wnt signaling pathway involved in neural crest cell differentiation|canonical Wnt signaling pathway involved in regulation of cell proliferation|synapse|positive regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|bone remodeling|embryonic camera-type eye morphogenesis|positive regulation of DNA-binding transcription factor activity|roof of mouth development|convergent extension|embryonic retina morphogenesis in camera-type eye|canonical Wnt signaling pathway|face morphogenesis|bone morphogenesis|branching involved in mammary gland duct morphogenesis|trachea cartilage morphogenesis|cellular response to cholesterol|dopaminergic neuron differentiation|negative regulation of protein serine/threonine kinase activity|coreceptor activity involved in Wnt signaling pathway|protein localization to plasma membrane|primitive streak formation|negative regulation of canonical Wnt signaling pathway|receptor-mediated endocytosis involved in cholesterol transport|Wnt signaling pathway involved in somitogenesis|axis elongation involved in somitogenesis|cell-cell adhesion|toxin transport|beta-catenin destruction complex disassembly|coreceptor activity involved in canonical Wnt signaling pathway|midbrain dopaminergic neuron differentiation|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt-Frizzled-LRP5/6 complex|Wnt signalosome" "hsa04150,hsa04310,hsa04928,hsa05010,hsa05022,hsa05200,hsa05224,hsa05225,hsa05226" "mTOR signaling pathway|Wnt signaling pathway|Parathyroid hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" LRP8 846.5952576 926.6547991 766.5357161 0.82720741 -0.273678986 0.451858621 1 5.910805609 5.100080399 7804 LDL receptor related protein 8 "GO:0001523,GO:0001540,GO:0004888,GO:0005041,GO:0005509,GO:0005515,GO:0005615,GO:0005875,GO:0005886,GO:0005901,GO:0006508,GO:0006629,GO:0006897,GO:0007165,GO:0007268,GO:0008035,GO:0009986,GO:0014069,GO:0016020,GO:0016021,GO:0019221,GO:0019894,GO:0021517,GO:0021541,GO:0021819,GO:0030229,GO:0030424,GO:0030425,GO:0032793,GO:0034185,GO:0038024,GO:0038025,GO:0038026,GO:0042493,GO:0042981,GO:0043025,GO:0043235,GO:0045088,GO:0047485,GO:0048306,GO:0048813,GO:0050731,GO:0050804,GO:0061003,GO:0061098,GO:0071363,GO:0071397,GO:1900006" retinoid metabolic process|amyloid-beta binding|transmembrane signaling receptor activity|low-density lipoprotein particle receptor activity|calcium ion binding|protein binding|extracellular space|microtubule associated complex|plasma membrane|caveola|proteolysis|lipid metabolic process|endocytosis|signal transduction|chemical synaptic transmission|high-density lipoprotein particle binding|cell surface|postsynaptic density|membrane|integral component of membrane|cytokine-mediated signaling pathway|kinesin binding|ventral spinal cord development|ammon gyrus development|layer formation in cerebral cortex|very-low-density lipoprotein particle receptor activity|axon|dendrite|positive regulation of CREB transcription factor activity|apolipoprotein binding|cargo receptor activity|reelin receptor activity|reelin-mediated signaling pathway|response to drug|regulation of apoptotic process|neuronal cell body|receptor complex|regulation of innate immune response|protein N-terminus binding|calcium-dependent protein binding|dendrite morphogenesis|positive regulation of peptidyl-tyrosine phosphorylation|modulation of chemical synaptic transmission|positive regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|cellular response to growth factor stimulus|cellular response to cholesterol|positive regulation of dendrite development LRPAP1 1706.024685 1720.350366 1691.699003 0.983345623 -0.024229515 0.942744512 1 8.340960849 8.555358279 4043 LDL receptor related protein associated protein 1 "GO:0001540,GO:0002091,GO:0005102,GO:0005515,GO:0005576,GO:0005768,GO:0005783,GO:0005793,GO:0005794,GO:0005796,GO:0005801,GO:0005886,GO:0007165,GO:0008201,GO:0009986,GO:0010916,GO:0012505,GO:0031904,GO:0032091,GO:0035473,GO:0048018,GO:0048019,GO:0048237,GO:0048259,GO:0050750,GO:0060548,GO:0070326,GO:0150093,GO:1900116,GO:1900222,GO:1900223,GO:2000272" amyloid-beta binding|negative regulation of receptor internalization|signaling receptor binding|protein binding|extracellular region|endosome|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|Golgi lumen|cis-Golgi network|plasma membrane|signal transduction|heparin binding|cell surface|negative regulation of very-low-density lipoprotein particle clearance|endomembrane system|endosome lumen|negative regulation of protein binding|lipase binding|receptor ligand activity|receptor antagonist activity|rough endoplasmic reticulum lumen|regulation of receptor-mediated endocytosis|low-density lipoprotein particle receptor binding|negative regulation of cell death|very-low-density lipoprotein particle receptor binding|amyloid-beta clearance by transcytosis|extracellular negative regulation of signal transduction|negative regulation of amyloid-beta clearance|positive regulation of amyloid-beta clearance|negative regulation of signaling receptor activity hsa04979 Cholesterol metabolism LRPPRC 2801.212893 2735.306335 2867.119452 1.048189527 0.067899599 0.831994362 1 20.89496475 22.84532751 10128 leucine rich pentatricopeptide repeat containing "GO:0000794,GO:0000961,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0005637,GO:0005640,GO:0005654,GO:0005739,GO:0005856,GO:0005874,GO:0008017,GO:0016020,GO:0031625,GO:0042645,GO:0047497,GO:0048471,GO:0048487,GO:0051015,GO:0051028,GO:0070129,GO:1990904" condensed nuclear chromosome|negative regulation of mitochondrial RNA catabolic process|single-stranded DNA binding|RNA binding|protein binding|nucleus|nuclear inner membrane|nuclear outer membrane|nucleoplasm|mitochondrion|cytoskeleton|microtubule|microtubule binding|membrane|ubiquitin protein ligase binding|mitochondrial nucleoid|mitochondrion transport along microtubule|perinuclear region of cytoplasm|beta-tubulin binding|actin filament binding|mRNA transport|regulation of mitochondrial translation|ribonucleoprotein complex LRR1 455.3821878 417.146903 493.6174727 1.183318081 0.242837928 0.563750396 1 14.06592479 17.36143909 122769 leucine rich repeat protein 1 "GO:0005515,GO:0005829,GO:0016567,GO:0043687" protein binding|cytosol|protein ubiquitination|post-translational protein modification LRRC1 227.9657408 227.3501369 228.5813446 1.005415469 0.007791792 0.997714735 1 1.058413677 1.109984556 55227 leucine rich repeat containing 1 "GO:0005829,GO:0016020" cytosol|membrane LRRC14 806.0645668 749.0375047 863.0916289 1.152267575 0.204475772 0.578504585 1 14.65280308 17.61124195 9684 leucine rich repeat containing 14 "GO:0005515,GO:0005737,GO:0019900,GO:0032088,GO:0034122" protein binding|cytoplasm|kinase binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway LRRC15 98.69098295 179.6472064 17.7347595 0.098719929 -3.34051483 1.10E-05 0.002667985 1.532249452 0.157779378 131578 leucine rich repeat containing 15 "GO:0001968,GO:0005518,GO:0005615,GO:0016021,GO:0030335,GO:0031012,GO:0043236,GO:0046813,GO:0062023,GO:0070062,GO:1903077" fibronectin binding|collagen binding|extracellular space|integral component of membrane|positive regulation of cell migration|extracellular matrix|laminin binding|receptor-mediated virion attachment to host cell|collagen-containing extracellular matrix|extracellular exosome|negative regulation of protein localization to plasma membrane LRRC17 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.059576113 10234 leucine rich repeat containing 17 "GO:0001649,GO:0005615,GO:0031012,GO:0033687,GO:0045671,GO:0048539" osteoblast differentiation|extracellular space|extracellular matrix|osteoblast proliferation|negative regulation of osteoclast differentiation|bone marrow development LRRC2 7.448866228 4.059823873 10.83790858 2.669551419 1.416597337 0.391522599 1 0.038642315 0.107601259 79442 leucine rich repeat containing 2 "GO:0004722,GO:0005737,GO:0006470,GO:0007165,GO:0043231" protein serine/threonine phosphatase activity|cytoplasm|protein dephosphorylation|signal transduction|intracellular membrane-bounded organelle LRRC20 781.5462794 824.1442463 738.9483124 0.896624973 -0.157423413 0.671587556 1 12.70624008 11.88348486 55222 leucine rich repeat containing 20 GO:0005515 protein binding LRRC23 62.73699656 79.16656553 46.30742758 0.584936675 -0.773647648 0.329340407 1 2.627462163 1.603102355 10233 leucine rich repeat containing 23 "GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0005829,GO:0008150" molecular_function|protein binding|cellular_component|cytoplasm|cytosol|biological_process LRRC24 21.4652547 19.2841634 23.646346 1.226205436 0.294200706 0.822957513 1 0.554299004 0.708962502 441381 leucine rich repeat containing 24 "GO:0005615,GO:0016021,GO:0031012,GO:0051965" extracellular space|integral component of membrane|extracellular matrix|positive regulation of synapse assembly LRRC26 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.127553199 0.129155493 389816 leucine rich repeat containing 26 "GO:0005249,GO:0005515,GO:0005737,GO:0005856,GO:0005887,GO:0008076,GO:0015459,GO:0044325,GO:0070062,GO:0071805,GO:0099104,GO:1903818" voltage-gated potassium channel activity|protein binding|cytoplasm|cytoskeleton|integral component of plasma membrane|voltage-gated potassium channel complex|potassium channel regulator activity|ion channel binding|extracellular exosome|potassium ion transmembrane transport|potassium channel activator activity|positive regulation of voltage-gated potassium channel activity LRRC27 39.06368061 43.64310664 34.48425458 0.790142069 -0.339816019 0.728410972 1 0.59069198 0.486835444 80313 leucine rich repeat containing 27 LRRC28 300.4042021 329.8606897 270.9477146 0.821400437 -0.283842381 0.550676866 1 1.802965709 1.544750434 123355 leucine rich repeat containing 28 LRRC29 21.42071737 16.23929549 26.60213925 1.638133825 0.712053221 0.528998684 1 0.247580683 0.423040614 26231 leucine rich repeat containing 29 GO:0005515 protein binding LRRC34 46.46800951 44.65806261 48.27795641 1.081058013 0.112443944 0.922033106 1 0.488715066 0.551087624 151827 leucine rich repeat containing 34 "GO:0003674,GO:0005575,GO:0005730,GO:0005737,GO:0008150,GO:0030154" molecular_function|cellular_component|nucleolus|cytoplasm|biological_process|cell differentiation LRRC37A 11.04574944 14.20938356 7.882115332 0.554711983 -0.850189203 0.555975575 1 0.139010073 0.080432163 9884 leucine rich repeat containing 37A GO:0016021 integral component of membrane LRRC37A2 8.508359524 9.134603715 7.882115332 0.862885307 -0.212759283 0.973293498 1 0.123468229 0.111128185 474170 leucine rich repeat containing 37 member A2 GO:0016021 integral component of membrane LRRC37A3 26.42126833 21.31407534 31.52846133 1.479231955 0.564848296 0.598127945 1 0.178781505 0.275851149 374819 leucine rich repeat containing 37 member A3 GO:0016021 integral component of membrane LRRC37B 231.8771069 225.320225 238.4339888 1.058200562 0.08161309 0.881705119 1 2.865814795 3.163239231 114659 leucine rich repeat containing 37B GO:0016021 integral component of membrane LRRC39 6.060044258 10.14955968 1.970528833 0.194149194 -2.364762376 0.199637567 1 0.266479727 0.053965437 127495 leucine rich repeat containing 39 "GO:0004722,GO:0005515,GO:0005737,GO:0006470,GO:0007165,GO:0031430,GO:0043231" protein serine/threonine phosphatase activity|protein binding|cytoplasm|protein dephosphorylation|signal transduction|M band|intracellular membrane-bounded organelle LRRC40 614.8841758 679.0055428 550.7628088 0.811131536 -0.301992209 0.438011487 1 12.22076594 10.33964535 55631 leucine rich repeat containing 40 "GO:0004722,GO:0005515,GO:0005737,GO:0006470,GO:0007165,GO:0016020,GO:0043231" protein serine/threonine phosphatase activity|protein binding|cytoplasm|protein dephosphorylation|signal transduction|membrane|intracellular membrane-bounded organelle LRRC41 1854.286691 1786.322504 1922.250877 1.076093971 0.105804068 0.745175856 1 21.8740167 24.5524405 10489 leucine rich repeat containing 41 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016020,GO:0016567,GO:0043687" protein binding|nucleus|cytoplasm|cytosol|membrane|protein ubiquitination|post-translational protein modification LRRC42 1029.067613 872.8621328 1185.273093 1.357915584 0.441393796 0.208289783 1 22.90538226 32.44339142 115353 leucine rich repeat containing 42 LRRC45 425.0225834 362.3392807 487.7058862 1.345992312 0.42867017 0.31518477 1 6.801781435 9.549512059 201255 leucine rich repeat containing 45 "GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0005886" protein binding|nucleoplasm|centrosome|cytosol|plasma membrane LRRC46 4.537610306 7.104691779 1.970528833 0.277355992 -1.850189203 0.383956367 1 0.213547522 0.061780016 90506 leucine rich repeat containing 46 LRRC47 1355.505609 1399.62428 1311.386938 0.936956408 -0.093946167 0.781347102 1 16.47363054 16.09995408 57470 leucine rich repeat containing 47 "GO:0003723,GO:0004826,GO:0005515" RNA binding|phenylalanine-tRNA ligase activity|protein binding LRRC49 346.8749332 341.0252054 352.7246611 1.034306719 0.048664073 0.920761427 1 4.726799011 5.099556543 54839 leucine rich repeat containing 49 "GO:0005737,GO:0005874,GO:0036158" cytoplasm|microtubule|outer dynein arm assembly LRRC4B 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.027178678 0 94030 leucine rich repeat containing 4B "GO:0005102,GO:0005886,GO:0042734,GO:0044300,GO:0051965,GO:0098978,GO:0099061,GO:0099151,GO:0099560,GO:1905606" signaling receptor binding|plasma membrane|presynaptic membrane|cerebellar mossy fiber|positive regulation of synapse assembly|glutamatergic synapse|integral component of postsynaptic density membrane|regulation of postsynaptic density assembly|synaptic membrane adhesion|regulation of presynapse assembly hsa04514 Cell adhesion molecules LRRC51 35.9594296 33.49354696 38.42531225 1.147245238 0.198173818 0.859125277 1 0.796773131 0.95346965 120356739 leucine-rich repeat-containing protein 51 LRRC56 61.0957964 68.00204988 54.18954291 0.796881021 -0.327563758 0.693011929 1 0.771346905 0.641149273 115399 leucine rich repeat containing 56 "GO:0005515,GO:0005929,GO:0030030" protein binding|cilium|cell projection organization LRRC57 292.0645894 264.9035077 319.225671 1.205063963 0.269109725 0.57544841 1 1.844689694 2.318725566 255252 leucine rich repeat containing 57 "GO:0016020,GO:0070062" membrane|extracellular exosome LRRC58 2147.707443 2447.05884 1848.356045 0.755337802 -0.404806104 0.207237295 1 15.65229825 12.33204965 116064 leucine rich repeat containing 58 LRRC59 5555.510674 5967.941094 5143.080254 0.861784688 -0.21460063 0.506374428 1 104.9497093 94.34001547 55379 leucine rich repeat containing 59 "GO:0003723,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0007165,GO:0016020,GO:0016021,GO:0042645,GO:0045296,GO:0046579" RNA binding|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|signal transduction|membrane|integral component of membrane|mitochondrial nucleoid|cadherin binding|positive regulation of Ras protein signal transduction LRRC61 484.107273 562.2856065 405.9289396 0.721926606 -0.47007592 0.254055414 1 10.28450067 7.744478674 65999 leucine rich repeat containing 61 "GO:0005515,GO:0005737,GO:0005829" protein binding|cytoplasm|cytosol LRRC63 12.06070541 16.23929549 7.882115332 0.485372985 -1.042834281 0.44253226 1 0.089965328 0.045547726 220416 leucine rich repeat containing 63 LRRC66 6.478447587 5.074779842 7.882115332 1.553193553 0.635237624 0.773446698 1 0.074823783 0.121221924 339977 leucine rich repeat containing 66 GO:0016021 integral component of membrane LRRC69 13.98669692 13.19442759 14.77896625 1.120091504 0.163616596 0.957372196 1 0.505102956 0.590132242 100130742 leucine rich repeat containing 69 GO:0007165 signal transduction LRRC70 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.023765113 0.072190934 100130733 leucine rich repeat containing 70 "GO:0005887,GO:0060760" integral component of plasma membrane|positive regulation of response to cytokine stimulus LRRC71 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.048161092 0 149499 leucine rich repeat containing 71 LRRC73 16.49439529 16.23929549 16.74949508 1.031417594 0.04462856 1 1 0.460763601 0.495711083 221424 leucine rich repeat containing 73 GO:0005515 protein binding LRRC75A 61.56145866 32.47859099 90.64432632 2.790894665 1.480727675 0.065744413 1 0.425045492 1.237356347 388341 leucine rich repeat containing 75A GO:0005737 cytoplasm LRRC75B 64.66570966 42.62815067 86.70326866 2.033943938 1.024279915 0.192058404 1 1.438351398 3.051545907 388886 leucine rich repeat containing 75B GO:0005737 cytoplasm LRRC8A 1729.098727 1782.26268 1675.934773 0.940341057 -0.088743985 0.78689865 1 17.13139444 16.80327917 56262 leucine rich repeat containing 8 VRAC subunit A "GO:0002329,GO:0005225,GO:0005253,GO:0005515,GO:0005886,GO:0005887,GO:0006820,GO:0006884,GO:0006970,GO:0009986,GO:0015698,GO:0015734,GO:0015810,GO:0016020,GO:0034214,GO:0034702,GO:0042802,GO:0055085,GO:0098656" pre-B cell differentiation|volume-sensitive anion channel activity|anion channel activity|protein binding|plasma membrane|integral component of plasma membrane|anion transport|cell volume homeostasis|response to osmotic stress|cell surface|inorganic anion transport|taurine transport|aspartate transmembrane transport|membrane|protein hexamerization|ion channel complex|identical protein binding|transmembrane transport|anion transmembrane transport LRRC8B 97.77054484 116.7199364 78.82115332 0.675301545 -0.566396237 0.409490228 1 0.503230869 0.354471192 23507 leucine rich repeat containing 8 VRAC subunit B "GO:0005225,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0015698,GO:0034702,GO:0055085,GO:0098656" volume-sensitive anion channel activity|protein binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|inorganic anion transport|ion channel complex|transmembrane transport|anion transmembrane transport LRRC8C 966.8514563 997.7017169 936.0011957 0.938157347 -0.092098184 0.797229524 1 5.433925399 5.317472903 84230 leucine rich repeat containing 8 VRAC subunit C "GO:0005225,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0015698,GO:0015734,GO:0015810,GO:0016020,GO:0034214,GO:0034702,GO:0055085,GO:0071470,GO:0098656" volume-sensitive anion channel activity|protein binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|inorganic anion transport|taurine transport|aspartate transmembrane transport|membrane|protein hexamerization|ion channel complex|transmembrane transport|cellular response to osmotic stress|anion transmembrane transport LRRC8D 719.8039498 812.9797307 626.6281689 0.770779572 -0.375609758 0.317340779 1 10.13153429 8.14556745 55144 leucine rich repeat containing 8 VRAC subunit D "GO:0005225,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0015698,GO:0015734,GO:0015810,GO:0016020,GO:0034702,GO:0055085,GO:0071470,GO:0098656" volume-sensitive anion channel activity|protein binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|inorganic anion transport|taurine transport|aspartate transmembrane transport|membrane|ion channel complex|transmembrane transport|cellular response to osmotic stress|anion transmembrane transport LRRC8E 377.2966424 366.3991046 388.1941801 1.059484522 0.083362511 0.855460257 1 4.072157575 4.500234255 80131 leucine rich repeat containing 8 VRAC subunit E "GO:0005225,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0015698,GO:0015810,GO:0034702,GO:0055085,GO:0071470,GO:0098656" volume-sensitive anion channel activity|protein binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|inorganic anion transport|aspartate transmembrane transport|ion channel complex|transmembrane transport|cellular response to osmotic stress|anion transmembrane transport LRRCC1 276.4339707 274.0381115 278.8298299 1.017485591 0.025008365 0.967073685 1 3.598409022 3.81904455 85444 leucine rich repeat and coiled-coil centrosomal protein 1 "GO:0005737,GO:0005813,GO:0005814,GO:0007049,GO:0051301" cytoplasm|centrosome|centriole|cell cycle|cell division LRRFIP1 1226.417166 1263.620181 1189.214151 0.941116776 -0.087554347 0.799125223 1 8.146372755 7.996937894 9208 LRR binding FLII interacting protein 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003725,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006357,GO:0032481,GO:0042803,GO:0045296,GO:0051092" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|double-stranded RNA binding|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|regulation of transcription by RNA polymerase II|positive regulation of type I interferon production|protein homodimerization activity|cadherin binding|positive regulation of NF-kappaB transcription factor activity" LRRFIP2 1225.041952 1102.242182 1347.841722 1.222818129 0.290209846 0.394981457 1 13.00971289 16.59378698 9209 LRR binding FLII interacting protein 2 "GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0016055,GO:0030275" "protein binding|cellular_component|regulation of transcription, DNA-templated|biological_process|Wnt signaling pathway|LRR domain binding" LRRIQ3 8.508359524 9.134603715 7.882115332 0.862885307 -0.212759283 0.973293498 1 0.125784517 0.113212972 127255 leucine rich repeats and IQ motif containing 3 GO:0005515 protein binding LRRIQ4 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.112530515 0.113944097 344657 leucine rich repeats and IQ motif containing 4 "GO:0004722,GO:0005737,GO:0006470,GO:0007165,GO:0043231" protein serine/threonine phosphatase activity|cytoplasm|protein dephosphorylation|signal transduction|intracellular membrane-bounded organelle LRRK1 1448.510414 1561.002279 1336.018549 0.85587226 -0.224532606 0.500594049 1 7.242511778 6.465678269 79705 leucine rich repeat kinase 1 "GO:0004722,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005829,GO:0006468,GO:0006470,GO:0007165,GO:0036035,GO:0042802,GO:0043231,GO:0045453,GO:0046872,GO:0050731,GO:0050732,GO:0090263,GO:0106310,GO:0106311,GO:1902533" protein serine/threonine phosphatase activity|protein binding|ATP binding|GTP binding|cytoplasm|mitochondrion|cytosol|protein phosphorylation|protein dephosphorylation|signal transduction|osteoclast development|identical protein binding|intracellular membrane-bounded organelle|bone resorption|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of peptidyl-tyrosine phosphorylation|positive regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity|positive regulation of intracellular signal transduction LRRN4 1868.032395 2928.147969 807.9168216 0.275913933 -1.857709785 2.76E-08 1.70E-05 26.39266146 7.595786482 164312 leucine rich repeat neuronal 4 "GO:0005515,GO:0005887,GO:0007616,GO:0008542,GO:0070062" protein binding|integral component of plasma membrane|long-term memory|visual learning|extracellular exosome LRRTM2 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.025430709 0.008583388 26045 leucine rich repeat transmembrane neuronal 2 "GO:0002091,GO:0005515,GO:0005615,GO:0042043,GO:0050808,GO:0051965,GO:0060076,GO:0060291,GO:0098685,GO:0098686,GO:0098978,GO:0098982,GO:0099060,GO:0099061,GO:0099151" negative regulation of receptor internalization|protein binding|extracellular space|neurexin family protein binding|synapse organization|positive regulation of synapse assembly|excitatory synapse|long-term synaptic potentiation|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic specialization membrane|integral component of postsynaptic density membrane|regulation of postsynaptic density assembly LRSAM1 869.9474097 872.8621328 867.0326866 0.993321458 -0.009667417 0.982219601 1 9.900870717 10.25838837 90678 leucine rich repeat and sterile alpha motif containing 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006914,GO:0016020,GO:0030163,GO:0045806,GO:0046755,GO:0046872,GO:0051865,GO:0061630,GO:0070086,GO:1904417,GO:2000786" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|autophagy|membrane|protein catabolic process|negative regulation of endocytosis|viral budding|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|ubiquitin-dependent endocytosis|positive regulation of xenophagy|positive regulation of autophagosome assembly LRTM2 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.050211418 0.050842162 654429 leucine rich repeats and transmembrane domains 2 "GO:0007411,GO:0008201,GO:0016021,GO:0048495,GO:0050919,GO:0051965" axon guidance|heparin binding|integral component of membrane|Roundabout binding|negative chemotaxis|positive regulation of synapse assembly LRTOMT 5.956123827 3.044867905 8.867379749 2.912237912 1.542128219 0.403727794 1 0.046575602 0.141482022 220074 leucine rich transmembrane and O-methyltransferase domain containing "GO:0005575,GO:0005783,GO:0005886,GO:0007605,GO:0008171,GO:0016021,GO:0016206,GO:0032259,GO:0032502,GO:0042135,GO:0042417,GO:0042424,GO:0060117,GO:0102084,GO:0102938" cellular_component|endoplasmic reticulum|plasma membrane|sensory perception of sound|O-methyltransferase activity|integral component of membrane|catechol O-methyltransferase activity|methylation|developmental process|neurotransmitter catabolic process|dopamine metabolic process|catecholamine catabolic process|auditory receptor cell development|L-dopa O-methyltransferase activity|orcinol O-methyltransferase activity "hsa00140,hsa00350,hsa04728" Steroid hormone biosynthesis|Tyrosine metabolism|Dopaminergic synapse LRWD1 658.0009994 629.2727004 686.7292983 1.091306357 0.126056159 0.744656937 1 14.75483441 16.79565537 222229 leucine rich repeats and WD repeat domain containing 1 "GO:0000776,GO:0000777,GO:0000781,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005664,GO:0005721,GO:0005730,GO:0005737,GO:0005815,GO:0006270,GO:0006325,GO:0008327,GO:0035064,GO:0043231,GO:0071169" "kinetochore|condensed chromosome kinetochore|chromosome, telomeric region|chromatin binding|protein binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|pericentric heterochromatin|nucleolus|cytoplasm|microtubule organizing center|DNA replication initiation|chromatin organization|methyl-CpG binding|methylated histone binding|intracellular membrane-bounded organelle|establishment of protein localization to chromatin" LSG1 1315.781788 1580.286443 1051.277132 0.66524467 -0.58804305 0.081774942 1 23.19882128 16.0976786 55341 large 60S subunit nuclear export GTPase 1 "GO:0000054,GO:0003924,GO:0005525,GO:0005654,GO:0005783,GO:0005829,GO:0015030,GO:0016020,GO:0016604,GO:0051168" ribosomal subunit export from nucleus|GTPase activity|GTP binding|nucleoplasm|endoplasmic reticulum|cytosol|Cajal body|membrane|nuclear body|nuclear export hsa03008 Ribosome biogenesis in eukaryotes LSM1 425.7945638 415.1169911 436.4721365 1.05144368 0.072371574 0.870234051 1 23.20553107 25.45033225 27257 "LSM1 homolog, mRNA degradation associated" "GO:0000290,GO:0000339,GO:0000375,GO:0000932,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006397,GO:0008380,GO:0016070,GO:0019827,GO:0030424,GO:0030425,GO:0036002,GO:0043025,GO:0043928,GO:0045665,GO:0071044,GO:1990124,GO:1990726" "deadenylation-dependent decapping of nuclear-transcribed mRNA|RNA cap binding|RNA splicing, via transesterification reactions|P-body|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA processing|RNA splicing|RNA metabolic process|stem cell population maintenance|axon|dendrite|pre-mRNA binding|neuronal cell body|exonucleolytic catabolism of deadenylated mRNA|negative regulation of neuron differentiation|histone mRNA catabolic process|messenger ribonucleoprotein complex|Lsm1-7-Pat1 complex" hsa03018 RNA degradation LSM10 316.153587 328.8457338 303.4614403 0.922807898 -0.115897743 0.808749302 1 19.36613525 18.64104235 84967 "LSM10, U7 small nuclear RNA associated" "GO:0005515,GO:0005654,GO:0005683,GO:0006369,GO:0006397,GO:0008334,GO:0008380,GO:0015030,GO:0016604,GO:0071208,GO:0071209,GO:1900087" protein binding|nucleoplasm|U7 snRNP|termination of RNA polymerase II transcription|mRNA processing|histone mRNA metabolic process|RNA splicing|Cajal body|nuclear body|histone pre-mRNA DCP binding|U7 snRNA binding|positive regulation of G1/S transition of mitotic cell cycle LSM11 392.9839225 394.8178717 391.1499734 0.990709898 -0.013465429 0.981894101 1 3.044941734 3.146599131 134353 "LSM11, U7 small nuclear RNA associated" "GO:0005515,GO:0005634,GO:0005654,GO:0005683,GO:0005697,GO:0006369,GO:0006398,GO:0008334,GO:0016604,GO:0071204,GO:0071209,GO:1900087" protein binding|nucleus|nucleoplasm|U7 snRNP|telomerase holoenzyme complex|termination of RNA polymerase II transcription|mRNA 3'-end processing by stem-loop binding and cleavage|histone mRNA metabolic process|nuclear body|histone pre-mRNA 3'end processing complex|U7 snRNA binding|positive regulation of G1/S transition of mitotic cell cycle LSM12 658.8472086 687.1251906 630.5692266 0.917691907 -0.12391821 0.748824972 1 9.375125773 8.97407995 124801 LSM12 homolog GO:0005515 protein binding LSM14A 2219.599578 2108.063546 2331.13561 1.105818472 0.145114576 0.651109883 1 29.13123651 33.60150186 26065 LSM14A mRNA processing body assembly factor "GO:0000932,GO:0003690,GO:0003723,GO:0003725,GO:0003727,GO:0003729,GO:0005515,GO:0005737,GO:0005829,GO:0007275,GO:0010494,GO:0017148,GO:0033962,GO:0034063,GO:0036464,GO:0039529,GO:0060340,GO:0072686,GO:0090307,GO:1990124" P-body|double-stranded DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|mRNA binding|protein binding|cytoplasm|cytosol|multicellular organism development|cytoplasmic stress granule|negative regulation of translation|P-body assembly|stress granule assembly|cytoplasmic ribonucleoprotein granule|RIG-I signaling pathway|positive regulation of type I interferon-mediated signaling pathway|mitotic spindle|mitotic spindle assembly|messenger ribonucleoprotein complex LSM14B 2127.520655 1942.625723 2312.415586 1.190355691 0.251392731 0.433729042 1 30.41333531 37.76215169 149986 LSM family member 14B "GO:0003723,GO:0003729,GO:0005515,GO:0006417,GO:0007275" RNA binding|mRNA binding|protein binding|regulation of translation|multicellular organism development LSM2 531.8980405 495.2985126 568.4975683 1.147787756 0.19885589 0.623355651 1 29.23673934 35.00309552 57819 "LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000244,GO:0000398,GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005737,GO:0005829,GO:0006402,GO:0017070,GO:0031267,GO:0043928,GO:0046540,GO:0071005,GO:0071011,GO:0071013,GO:0120115,GO:1990726" "spliceosomal tri-snRNP complex assembly|mRNA splicing, via spliceosome|P-body|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|cytoplasm|cytosol|mRNA catabolic process|U6 snRNA binding|small GTPase binding|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|Lsm2-8 complex|Lsm1-7-Pat1 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM3 880.3817607 878.9518686 881.8116528 1.00325363 0.004686376 0.993220933 1 13.25269764 13.86854689 27258 "LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000398,GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005829,GO:0006397,GO:0030629,GO:0033962,GO:0043928,GO:0046540,GO:0071005,GO:0071011,GO:0071013,GO:0120115,GO:1990726" "mRNA splicing, via spliceosome|P-body|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|cytosol|mRNA processing|U6 snRNA 3'-end binding|P-body assembly|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|Lsm2-8 complex|Lsm1-7-Pat1 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM4 2366.877557 2342.518375 2391.236739 1.020797431 0.029696603 0.927266408 1 69.62458438 74.13411609 25804 "LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000387,GO:0000398,GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005829,GO:0008380,GO:0016020,GO:0017070,GO:0032991,GO:0033962,GO:0042731,GO:0043928,GO:0046540,GO:0071005,GO:0097526,GO:0120115" "spliceosomal snRNP assembly|mRNA splicing, via spliceosome|P-body|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|cytosol|RNA splicing|membrane|U6 snRNA binding|protein-containing complex|P-body assembly|PH domain binding|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|spliceosomal tri-snRNP complex|Lsm2-8 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM5 658.1885512 709.4542219 606.9228806 0.855478566 -0.225196386 0.557731782 1 14.33241066 12.7892273 23658 "LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005737,GO:0005829,GO:0006397,GO:0006402,GO:0009617,GO:0043928,GO:0046540,GO:0046982,GO:0071005,GO:0120115,GO:1990726" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|cytoplasm|cytosol|mRNA processing|mRNA catabolic process|response to bacterium|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|protein heterodimerization activity|U2-type precatalytic spliceosome|Lsm2-8 complex|Lsm1-7-Pat1 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM6 281.6005468 256.78386 306.4172335 1.193288525 0.254942914 0.600473197 1 11.01202086 13.70655835 11157 "LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000398,GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005730,GO:0005732,GO:0005737,GO:0005829,GO:0006402,GO:0008033,GO:0008380,GO:0030490,GO:0030532,GO:0043928,GO:0046540,GO:0046982,GO:0071005,GO:0120115" "mRNA splicing, via spliceosome|P-body|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|nucleolus|sno(s)RNA-containing ribonucleoprotein complex|cytoplasm|cytosol|mRNA catabolic process|tRNA processing|RNA splicing|maturation of SSU-rRNA|small nuclear ribonucleoprotein complex|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|protein heterodimerization activity|U2-type precatalytic spliceosome|Lsm2-8 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM7 726.9883137 765.2768002 688.6998272 0.899935588 -0.152106349 0.686830224 1 58.54768911 54.95878388 51690 "LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005689,GO:0005829,GO:0017070,GO:0043928,GO:0046540,GO:0071004,GO:0071005,GO:0071013,GO:0097526,GO:0120115,GO:1990726,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|U12-type spliceosomal complex|cytosol|U6 snRNA binding|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U2-type precatalytic spliceosome|catalytic step 2 spliceosome|spliceosomal tri-snRNP complex|Lsm2-8 complex|Lsm1-7-Pat1 complex|ribonucleoprotein complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM8 711.1755863 627.2427885 795.1083842 1.267624593 0.342127554 0.36380772 1 2.565215961 3.391802213 51691 "LSM8 homolog, U6 small nuclear RNA associated" "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0016070,GO:0017070,GO:0046540,GO:0071005,GO:0071011,GO:0120115" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|RNA metabolic process|U6 snRNA binding|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|precatalytic spliceosome|Lsm2-8 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSMEM1 49.00539943 49.73284245 48.27795641 0.970745971 -0.042834281 0.98693431 1 0.371284349 0.375948338 286006 leucine rich single-pass membrane protein 1 "GO:0005515,GO:0016021" protein binding|integral component of membrane LSR 302.7067812 285.2026271 320.2109354 1.122748898 0.167035306 0.727821824 1 6.571659203 7.696151367 51599 lipolysis stimulated lipoprotein receptor "GO:0001889,GO:0005886,GO:0016021,GO:0019216,GO:0034361,GO:0034362,GO:0035633,GO:0042627,GO:0060856,GO:0061436,GO:0061689,GO:0061833,GO:0070062,GO:1904274" liver development|plasma membrane|integral component of membrane|regulation of lipid metabolic process|very-low-density lipoprotein particle|low-density lipoprotein particle|maintenance of blood-brain barrier|chylomicron|establishment of blood-brain barrier|establishment of skin barrier|tricellular tight junction|protein localization to tricellular tight junction|extracellular exosome|tricellular tight junction assembly LSS 2111.872468 1984.238918 2239.506019 1.128647361 0.174594795 0.587137167 1 20.02684361 23.57690028 4047 lanosterol synthase "GO:0000250,GO:0005515,GO:0005789,GO:0005811,GO:0006694,GO:0006695,GO:0016020,GO:0016104,GO:0031647,GO:0042300,GO:0045540" lanosterol synthase activity|protein binding|endoplasmic reticulum membrane|lipid droplet|steroid biosynthetic process|cholesterol biosynthetic process|membrane|triterpenoid biosynthetic process|regulation of protein stability|beta-amyrin synthase activity|regulation of cholesterol biosynthetic process hsa00100 Steroid biosynthesis LST1 11.01605789 12.17947162 9.852644165 0.808954975 -0.305868687 0.884333199 1 0.693866447 0.585485531 7940 leukocyte specific transcript 1 "GO:0000139,GO:0000902,GO:0005737,GO:0005794,GO:0006955,GO:0008360,GO:0009653,GO:0016021,GO:0016358,GO:0050672" Golgi membrane|cell morphogenesis|cytoplasm|Golgi apparatus|immune response|regulation of cell shape|anatomical structure morphogenesis|integral component of membrane|dendrite development|negative regulation of lymphocyte proliferation LTA4H 4924.666797 4938.775742 4910.557852 0.994286461 -0.008266533 0.980143584 1 99.17984472 102.8610325 4048 leukotriene A4 hydrolase "GO:0003723,GO:0004177,GO:0004301,GO:0004463,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006508,GO:0006691,GO:0008233,GO:0008270,GO:0019370,GO:0042759,GO:0043171,GO:0043312,GO:0044267,GO:0045148,GO:0070006,GO:0070062,GO:1904724,GO:1904813" RNA binding|aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|proteolysis|leukotriene metabolic process|peptidase activity|zinc ion binding|leukotriene biosynthetic process|long-chain fatty acid biosynthetic process|peptide catabolic process|neutrophil degranulation|cellular protein metabolic process|tripeptide aminopeptidase activity|metalloaminopeptidase activity|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen hsa00590 Arachidonic acid metabolism LTB 157.8392611 148.1835714 167.4949508 1.130320651 0.176732096 0.769652239 1 8.404227469 9.908670583 4050 lymphotoxin beta "GO:0005102,GO:0005125,GO:0005164,GO:0005575,GO:0005615,GO:0005886,GO:0006955,GO:0007165,GO:0007267,GO:0010467,GO:0016021,GO:0032735,GO:0033209,GO:0043588,GO:0048535" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|cellular_component|extracellular space|plasma membrane|immune response|signal transduction|cell-cell signaling|gene expression|integral component of membrane|positive regulation of interleukin-12 production|tumor necrosis factor-mediated signaling pathway|skin development|lymph node development "hsa04060,hsa04064,hsa05323" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Rheumatoid arthritis LTB4R 154.5365718 191.826678 117.2464656 0.611210426 -0.710258942 0.226560309 1 2.104254823 1.341544289 1241 leukotriene B4 receptor "GO:0000166,GO:0001632,GO:0004974,GO:0005886,GO:0005887,GO:0006936,GO:0006954,GO:0006955,GO:0007186,GO:0007200,GO:0007218,GO:0008528,GO:0045121,GO:0061737" nucleotide binding|leukotriene B4 receptor activity|leukotriene receptor activity|plasma membrane|integral component of plasma membrane|muscle contraction|inflammatory response|immune response|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|G protein-coupled peptide receptor activity|membrane raft|leukotriene signaling pathway hsa04080 Neuroactive ligand-receptor interaction LTB4R2 37.63032131 46.68797455 28.57266808 0.611992025 -0.708415242 0.449789438 1 1.519653731 0.97007728 56413 leukotriene B4 receptor 2 "GO:0001632,GO:0004974,GO:0005654,GO:0005886,GO:0005887,GO:0006935,GO:0006954,GO:0007186,GO:0007194,GO:0007218,GO:0008528,GO:0016020,GO:0061737" leukotriene B4 receptor activity|leukotriene receptor activity|nucleoplasm|plasma membrane|integral component of plasma membrane|chemotaxis|inflammatory response|G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|neuropeptide signaling pathway|G protein-coupled peptide receptor activity|membrane|leukotriene signaling pathway "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction LTBP1 652.5375077 626.2278325 678.847183 1.084025889 0.116399212 0.76439428 1 4.633488753 5.239184557 4052 latent transforming growth factor beta binding protein 1 "GO:0001527,GO:0005024,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005788,GO:0007178,GO:0031012,GO:0032991,GO:0035583,GO:0043687,GO:0044267,GO:0050431,GO:0050436,GO:0062023,GO:1901388" microfibril|transforming growth factor beta-activated receptor activity|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|endoplasmic reticulum lumen|transmembrane receptor protein serine/threonine kinase signaling pathway|extracellular matrix|protein-containing complex|sequestering of TGFbeta in extracellular matrix|post-translational protein modification|cellular protein metabolic process|transforming growth factor beta binding|microfibril binding|collagen-containing extracellular matrix|regulation of transforming growth factor beta activation hsa04350 TGF-beta signaling pathway LTBP2 5402.723921 4817.995982 5987.451859 1.24272662 0.313508961 0.330978335 1 28.84332147 37.38839319 4053 latent transforming growth factor beta binding protein 2 "GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006605,GO:0007179,GO:0008201,GO:0009306,GO:0019838,GO:0031012,GO:0050436,GO:0062023,GO:0070062,GO:0097435" extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|extracellular space|protein targeting|transforming growth factor beta receptor signaling pathway|heparin binding|protein secretion|growth factor binding|extracellular matrix|microfibril binding|collagen-containing extracellular matrix|extracellular exosome|supramolecular fiber organization LTBP3 3043.631739 3849.727988 2237.53549 0.581219114 -0.782845947 0.01430572 0.528337145 36.80859762 22.31542123 4054 latent transforming growth factor beta binding protein 3 "GO:0005509,GO:0005515,GO:0005576,GO:0007179,GO:0030502,GO:0032331,GO:0036363,GO:0045780,GO:0046849,GO:0048251,GO:0050431,GO:0060349,GO:0060430,GO:0062023,GO:0070062,GO:1902462,GO:2000741" calcium ion binding|protein binding|extracellular region|transforming growth factor beta receptor signaling pathway|negative regulation of bone mineralization|negative regulation of chondrocyte differentiation|transforming growth factor beta activation|positive regulation of bone resorption|bone remodeling|elastic fiber assembly|transforming growth factor beta binding|bone morphogenesis|lung saccule development|collagen-containing extracellular matrix|extracellular exosome|positive regulation of mesenchymal stem cell proliferation|positive regulation of mesenchymal stem cell differentiation LTBP4 2107.637217 1930.446252 2284.828182 1.183575134 0.243151293 0.449221249 1 17.9493836 22.15956859 8425 latent transforming growth factor beta binding protein 4 "GO:0001527,GO:0001558,GO:0005024,GO:0005178,GO:0005201,GO:0005509,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0006457,GO:0007179,GO:0007275,GO:0017015,GO:0030162,GO:0030252,GO:0031012,GO:0045595,GO:0050431,GO:0062023" microfibril|regulation of cell growth|transforming growth factor beta-activated receptor activity|integrin binding|extracellular matrix structural constituent|calcium ion binding|protein binding|glycosaminoglycan binding|extracellular region|extracellular space|protein folding|transforming growth factor beta receptor signaling pathway|multicellular organism development|regulation of transforming growth factor beta receptor signaling pathway|regulation of proteolysis|growth hormone secretion|extracellular matrix|regulation of cell differentiation|transforming growth factor beta binding|collagen-containing extracellular matrix LTBR 3203.369276 3049.942685 3356.795867 1.100609491 0.138302675 0.664087253 1 56.27280053 64.6022602 4055 lymphotoxin beta receptor "GO:0005515,GO:0005794,GO:0005886,GO:0006915,GO:0006955,GO:0007165,GO:0016021,GO:0016032,GO:0031625,GO:0033209,GO:0042802,GO:0043011,GO:0043123,GO:0046330,GO:0071260,GO:2001238" protein binding|Golgi apparatus|plasma membrane|apoptotic process|immune response|signal transduction|integral component of membrane|viral process|ubiquitin protein ligase binding|tumor necrosis factor-mediated signaling pathway|identical protein binding|myeloid dendritic cell differentiation|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade|cellular response to mechanical stimulus|positive regulation of extrinsic apoptotic signaling pathway "hsa04060,hsa04061,hsa04064,hsa04066,hsa04672,hsa05166,hsa05203" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NF-kappa B signaling pathway|HIF-1 signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Viral carcinogenesis LTC4S 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.192524117 0 4056 leukotriene C4 synthase "GO:0004364,GO:0004464,GO:0004602,GO:0005515,GO:0005635,GO:0005640,GO:0005783,GO:0005789,GO:0006691,GO:0008047,GO:0008289,GO:0016021,GO:0019370,GO:0019372,GO:0031965,GO:0042759,GO:0042802,GO:0043231,GO:0050790,GO:0098869,GO:2001301" glutathione transferase activity|leukotriene-C4 synthase activity|glutathione peroxidase activity|protein binding|nuclear envelope|nuclear outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|leukotriene metabolic process|enzyme activator activity|lipid binding|integral component of membrane|leukotriene biosynthetic process|lipoxygenase pathway|nuclear membrane|long-chain fatty acid biosynthetic process|identical protein binding|intracellular membrane-bounded organelle|regulation of catalytic activity|cellular oxidant detoxification|lipoxin biosynthetic process hsa00590 Arachidonic acid metabolism LTN1 1014.698885 968.2679938 1061.129777 1.095905042 0.132122797 0.708666677 1 5.811727666 6.643456721 26046 listerin E3 ubiquitin protein ligase 1 "GO:0005515,GO:0005829,GO:0008270,GO:0043023,GO:0051865,GO:0061630,GO:0072344,GO:1990112,GO:1990116" protein binding|cytosol|zinc ion binding|ribosomal large subunit binding|protein autoubiquitination|ubiquitin protein ligase activity|rescue of stalled ribosome|RQC complex|ribosome-associated ubiquitin-dependent protein catabolic process LTO1 389.4315766 387.7131799 391.1499734 1.008864268 0.012732088 0.983359325 1 7.905114651 8.318726446 220064 LTO1 maturation factor of ABCE1 "GO:0000723,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006413,GO:0042273,GO:0106035" telomere maintenance|molecular_function|protein binding|cellular_component|nucleus|translational initiation|ribosomal large subunit biogenesis|protein maturation by [4Fe-4S] cluster transfer LTV1 464.5113484 502.4032043 426.6194924 0.849157586 -0.235895781 0.573000263 1 13.73175927 12.16271149 84946 LTV1 ribosome biogenesis factor "GO:0000056,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0030688,GO:0042274" "ribosomal small subunit export from nucleus|protein binding|nucleus|nucleoplasm|cytosol|preribosome, small subunit precursor|ribosomal small subunit biogenesis" LUC7L 382.7843823 438.4609783 327.1077863 0.746036255 -0.422682352 0.33634457 1 8.469298915 6.590575267 55692 LUC7 like "GO:0003729,GO:0005515,GO:0005685,GO:0006376,GO:0042802,GO:0071004" mRNA binding|protein binding|U1 snRNP|mRNA splice site selection|identical protein binding|U2-type prespliceosome LUC7L2 160.8665616 186.7518982 134.9812251 0.722783685 -0.468364154 0.420414979 1 3.312898361 2.497654616 51631 "LUC7 like 2, pre-mRNA splicing factor" "GO:0003723,GO:0003729,GO:0005515,GO:0005685,GO:0006376,GO:0016607,GO:0019899,GO:0071004" RNA binding|mRNA binding|protein binding|U1 snRNP|mRNA splice site selection|nuclear speck|enzyme binding|U2-type prespliceosome LUC7L3 2300.281896 2167.945948 2432.617844 1.122084177 0.166180908 0.603803059 1 30.07362756 35.19874547 51747 LUC7 like 3 pre-mRNA splicing factor "GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005685,GO:0006376,GO:0008380,GO:0016607,GO:0071004" DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|U1 snRNP|mRNA splice site selection|RNA splicing|nuclear speck|U2-type prespliceosome LUM 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.173206834 0.07794783 4060 lumican "GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005583,GO:0005615,GO:0005796,GO:0007601,GO:0014070,GO:0018146,GO:0030021,GO:0030198,GO:0030199,GO:0031012,GO:0032914,GO:0042340,GO:0043202,GO:0045944,GO:0051216,GO:0062023,GO:0070062,GO:0070848" extracellular matrix structural constituent|protein binding|collagen binding|extracellular region|fibrillar collagen trimer|extracellular space|Golgi lumen|visual perception|response to organic cyclic compound|keratan sulfate biosynthetic process|extracellular matrix structural constituent conferring compression resistance|extracellular matrix organization|collagen fibril organization|extracellular matrix|positive regulation of transforming growth factor beta1 production|keratan sulfate catabolic process|lysosomal lumen|positive regulation of transcription by RNA polymerase II|cartilage development|collagen-containing extracellular matrix|extracellular exosome|response to growth factor hsa05205 Proteoglycans in cancer LURAP1 145.3034909 99.4656849 191.1412968 1.921680799 0.942368717 0.116651959 1 2.724492183 5.461132915 541468 leucine rich adaptor protein 1 "GO:0001819,GO:0005515,GO:0005737,GO:0005829,GO:0016477,GO:0031032,GO:0042641,GO:0043123,GO:0043231" positive regulation of cytokine production|protein binding|cytoplasm|cytosol|cell migration|actomyosin structure organization|actomyosin|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle LURAP1L 163.6590513 175.5873825 151.7307201 0.864132251 -0.210675968 0.721244109 1 2.879819135 2.595741001 286343 leucine rich adaptor protein 1 like "GO:0005515,GO:0043123" protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling LUZP1 1641.222642 1702.081159 1580.364124 0.928489288 -0.107042828 0.745383781 1 9.69678359 9.391187917 7798 leucine zipper protein 1 "GO:0003281,GO:0005634,GO:0016020,GO:0021503,GO:0060840,GO:0070062" ventricular septum development|nucleus|membrane|neural fold bending|artery development|extracellular exosome LVRN 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.022330121 0.033915941 206338 laeverin "GO:0005737,GO:0005886,GO:0006508,GO:0007165,GO:0008217,GO:0008270,GO:0016021,GO:0042277,GO:0043171,GO:0070006" cytoplasm|plasma membrane|proteolysis|signal transduction|regulation of blood pressure|zinc ion binding|integral component of membrane|peptide binding|peptide catabolic process|metalloaminopeptidase activity LXN 66.29206405 52.77771036 79.80641774 1.512123531 0.596576003 0.446306061 1 2.495802839 3.936529188 56925 latexin "GO:0005515,GO:0005615,GO:0005737,GO:0006954,GO:0008191,GO:0008201,GO:0010951,GO:0050965" protein binding|extracellular space|cytoplasm|inflammatory response|metalloendopeptidase inhibitor activity|heparin binding|negative regulation of endopeptidase activity|detection of temperature stimulus involved in sensory perception of pain LY6E 955.6369601 1039.314912 871.9590086 0.838974789 -0.253300636 0.476391584 1 46.54079027 40.72851669 4061 lymphocyte antigen 6 family member E "GO:0005515,GO:0005576,GO:0005886,GO:0007166,GO:0030550,GO:0031225,GO:0046597,GO:2000272" protein binding|extracellular region|plasma membrane|cell surface receptor signaling pathway|acetylcholine receptor inhibitor activity|anchored component of membrane|negative regulation of viral entry into host cell|negative regulation of signaling receptor activity LY6G5B 70.4261168 65.97213794 74.88009566 1.135026058 0.182725419 0.825849754 1 4.316868283 5.110819692 58496 lymphocyte antigen 6 family member G5B "GO:0005576,GO:0009897,GO:0032991,GO:0042802" extracellular region|external side of plasma membrane|protein-containing complex|identical protein binding LY6G5C 8.434130644 4.059823873 12.80843742 3.154924404 1.657605437 0.28583743 1 0.283217296 0.932018772 80741 lymphocyte antigen 6 family member G5C "GO:0005576,GO:0009897,GO:0032991,GO:0042802" extracellular region|external side of plasma membrane|protein-containing complex|identical protein binding LY6K 2826.27008 2090.809295 3561.730866 1.703517807 0.768517029 0.01624076 0.562985307 32.16649904 57.15660216 54742 lymphocyte antigen 6 family member K "GO:0001669,GO:0005576,GO:0005886,GO:0007339,GO:0031225,GO:0045121" acrosomal vesicle|extracellular region|plasma membrane|binding of sperm to zona pellucida|anchored component of membrane|membrane raft LY96 57.06566407 61.91231407 52.21901408 0.843435024 -0.245651164 0.778875646 1 2.474854218 2.177294535 23643 lymphocyte antigen 96 "GO:0001530,GO:0001875,GO:0002224,GO:0002755,GO:0002756,GO:0005515,GO:0005615,GO:0005886,GO:0006954,GO:0006968,GO:0007166,GO:0007249,GO:0010008,GO:0015026,GO:0031226,GO:0031663,GO:0031666,GO:0032496,GO:0032497,GO:0032760,GO:0034128,GO:0034142,GO:0035662,GO:0035666,GO:0045087,GO:0046696,GO:0070266,GO:0071222,GO:0097190" lipopolysaccharide binding|lipopolysaccharide immune receptor activity|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|protein binding|extracellular space|plasma membrane|inflammatory response|cellular defense response|cell surface receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|endosome membrane|coreceptor activity|intrinsic component of plasma membrane|lipopolysaccharide-mediated signaling pathway|positive regulation of lipopolysaccharide-mediated signaling pathway|response to lipopolysaccharide|detection of lipopolysaccharide|positive regulation of tumor necrosis factor production|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 4 signaling pathway|Toll-like receptor 4 binding|TRIF-dependent toll-like receptor signaling pathway|innate immune response|lipopolysaccharide receptor complex|necroptotic process|cellular response to lipopolysaccharide|apoptotic signaling pathway "hsa04064,hsa04620,hsa05132,hsa05133,hsa05145" NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Salmonella infection|Pertussis|Toxoplasmosis LYAR 270.356359 296.3671428 244.3455753 0.82446918 -0.27846253 0.57183676 1 7.554076628 6.496384801 55646 Ly1 antibody reactive "GO:0000122,GO:0001750,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0033613,GO:0042802,GO:0045087,GO:0045824,GO:0045943,GO:0046872,GO:0048821,GO:0050766,GO:0140416" negative regulation of transcription by RNA polymerase II|photoreceptor outer segment|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|activating transcription factor binding|identical protein binding|innate immune response|negative regulation of innate immune response|positive regulation of transcription by RNA polymerase I|metal ion binding|erythrocyte development|positive regulation of phagocytosis|transcription regulator inhibitor activity LYG1 8.567742628 13.19442759 3.941057666 0.298691068 -1.743273999 0.256867275 1 0.275794969 0.085925982 129530 lysozyme g1 "GO:0003796,GO:0005515,GO:0005576,GO:0009253,GO:0016998,GO:0050830" lysozyme activity|protein binding|extracellular region|peptidoglycan catabolic process|cell wall macromolecule catabolic process|defense response to Gram-positive bacterium LYL1 77.86013725 69.01700585 86.70326866 1.256259491 0.329134496 0.664442779 1 2.360207879 3.09275517 4066 LYL1 basic helix-loop-helix family member "GO:0000785,GO:0000978,GO:0000981,GO:0001955,GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0030183,GO:0045893,GO:0046983,GO:0060216" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|blood vessel maturation|DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|B cell differentiation|positive regulation of transcription, DNA-templated|protein dimerization activity|definitive hemopoiesis" hsa05202 Transcriptional misregulation in cancer bHLH LYN 1218.116647 1268.69496 1167.538334 0.92026718 -0.119875317 0.7268655 1 8.76004418 8.408841376 4067 "LYN proto-oncogene, Src family tyrosine kinase" "GO:0001782,GO:0001817,GO:0001932,GO:0001933,GO:0001934,GO:0002223,GO:0002250,GO:0002431,GO:0002513,GO:0002553,GO:0002576,GO:0002762,GO:0002768,GO:0002774,GO:0002902,GO:0004713,GO:0004715,GO:0005102,GO:0005161,GO:0005178,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005758,GO:0005794,GO:0005829,GO:0005886,GO:0005912,GO:0006468,GO:0006974,GO:0006991,GO:0007165,GO:0007169,GO:0007596,GO:0008284,GO:0008285,GO:0009636,GO:0009725,GO:0009743,GO:0010976,GO:0014003,GO:0014068,GO:0014069,GO:0014070,GO:0016032,GO:0016301,GO:0017124,GO:0018108,GO:0030061,GO:0030154,GO:0030168,GO:0030218,GO:0030335,GO:0030889,GO:0031175,GO:0031234,GO:0031295,GO:0031625,GO:0031663,GO:0031668,GO:0032868,GO:0033003,GO:0033628,GO:0034136,GO:0034142,GO:0034144,GO:0034605,GO:0034666,GO:0035556,GO:0038083,GO:0038095,GO:0038096,GO:0042127,GO:0042493,GO:0042531,GO:0043015,GO:0043200,GO:0043208,GO:0043231,GO:0043304,GO:0043407,GO:0043552,GO:0044325,GO:0045087,GO:0045121,GO:0045646,GO:0046579,GO:0046777,GO:0046875,GO:0048013,GO:0048471,GO:0048678,GO:0050727,GO:0050777,GO:0050853,GO:0050855,GO:0050900,GO:0051219,GO:0051272,GO:0051279,GO:0060252,GO:0060369,GO:0060397,GO:0070062,GO:0070304,GO:0070372,GO:0070373,GO:0070447,GO:0070667,GO:0070668,GO:0071300,GO:0090025,GO:0090330,GO:0097028,GO:0098978,GO:0099091,GO:0140031,GO:1902532,GO:1902961,GO:2000670" "B cell homeostasis|regulation of cytokine production|regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|stimulatory C-type lectin receptor signaling pathway|adaptive immune response|Fc receptor mediated stimulatory signaling pathway|tolerance induction to self antigen|histamine secretion by mast cell|platelet degranulation|negative regulation of myeloid leukocyte differentiation|immune response-regulating cell surface receptor signaling pathway|Fc receptor mediated inhibitory signaling pathway|regulation of B cell apoptotic process|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|platelet-derived growth factor receptor binding|integrin binding|protein binding|ATP binding|nucleus|cytoplasm|mitochondrial intermembrane space|Golgi apparatus|cytosol|plasma membrane|adherens junction|protein phosphorylation|cellular response to DNA damage stimulus|response to sterol depletion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|blood coagulation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to toxic substance|response to hormone|response to carbohydrate|positive regulation of neuron projection development|oligodendrocyte development|positive regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|response to organic cyclic compound|viral process|kinase activity|SH3 domain binding|peptidyl-tyrosine phosphorylation|mitochondrial crista|cell differentiation|platelet activation|erythrocyte differentiation|positive regulation of cell migration|negative regulation of B cell proliferation|neuron projection development|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|cellular response to extracellular stimulus|response to insulin|regulation of mast cell activation|regulation of cell adhesion mediated by integrin|negative regulation of toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|negative regulation of toll-like receptor 4 signaling pathway|cellular response to heat|integrin alpha2-beta1 complex|intracellular signal transduction|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell population proliferation|response to drug|positive regulation of tyrosine phosphorylation of STAT protein|gamma-tubulin binding|response to amino acid|glycosphingolipid binding|intracellular membrane-bounded organelle|regulation of mast cell degranulation|negative regulation of MAP kinase activity|positive regulation of phosphatidylinositol 3-kinase activity|ion channel binding|innate immune response|membrane raft|regulation of erythrocyte differentiation|positive regulation of Ras protein signal transduction|protein autophosphorylation|ephrin receptor binding|ephrin receptor signaling pathway|perinuclear region of cytoplasm|response to axon injury|regulation of inflammatory response|negative regulation of immune response|B cell receptor signaling pathway|regulation of B cell receptor signaling pathway|leukocyte migration|phosphoprotein binding|positive regulation of cellular component movement|regulation of release of sequestered calcium ion into cytosol|positive regulation of glial cell proliferation|positive regulation of Fc receptor mediated stimulatory signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|extracellular exosome|positive regulation of stress-activated protein kinase signaling cascade|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|positive regulation of oligodendrocyte progenitor proliferation|negative regulation of mast cell proliferation|positive regulation of mast cell proliferation|cellular response to retinoic acid|regulation of monocyte chemotaxis|regulation of platelet aggregation|dendritic cell differentiation|glutamatergic synapse|postsynaptic specialization, intracellular component|phosphorylation-dependent protein binding|negative regulation of intracellular signal transduction|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of dendritic cell apoptotic process" "hsa04062,hsa04064,hsa04611,hsa04662,hsa04664,hsa04666,hsa04730,hsa05120,hsa05167,hsa05169,hsa05203" Chemokine signaling pathway|NF-kappa B signaling pathway|Platelet activation|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Long-term depression|Epithelial cell signaling in Helicobacter pylori infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Viral carcinogenesis LYPD1 51.5724809 56.83753423 46.30742758 0.814733225 -0.295600352 0.740585683 1 0.719655149 0.611583549 116372 LY6/PLAUR domain containing 1 "GO:0005576,GO:0005886,GO:0030550,GO:0031225,GO:0045202,GO:0095500,GO:2000272" extracellular region|plasma membrane|acetylcholine receptor inhibitor activity|anchored component of membrane|synapse|acetylcholine receptor signaling pathway|negative regulation of signaling receptor activity LYPD3 268.0186452 405.9823873 130.054903 0.32034617 -1.642296352 0.001046923 0.093355223 12.52227509 4.18426042 27076 LY6/PLAUR domain containing 3 "GO:0005576,GO:0005615,GO:0005886,GO:0007160,GO:0016021,GO:0043236,GO:0046658" extracellular region|extracellular space|plasma membrane|cell-matrix adhesion|integral component of membrane|laminin binding|anchored component of plasma membrane LYPD5 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.059449429 0.040130812 284348 LY6/PLAUR domain containing 5 "GO:0005515,GO:0005576,GO:0005886,GO:0007160,GO:0031225,GO:0043236" protein binding|extracellular region|plasma membrane|cell-matrix adhesion|anchored component of membrane|laminin binding LYPD6 375.1858206 255.768904 494.6027371 1.933787608 0.951429349 0.032078101 0.801045165 1.844218777 3.719950339 130574 LY6/PLAUR domain containing 6 "GO:0005515,GO:0005576,GO:0005737,GO:0005886,GO:0030548,GO:0030550,GO:0031225,GO:0043005,GO:0045121,GO:0045202,GO:0090263,GO:0099601,GO:2000272" protein binding|extracellular region|cytoplasm|plasma membrane|acetylcholine receptor regulator activity|acetylcholine receptor inhibitor activity|anchored component of membrane|neuron projection|membrane raft|synapse|positive regulation of canonical Wnt signaling pathway|regulation of neurotransmitter receptor activity|negative regulation of signaling receptor activity LYPD8 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.132712408 0.179172681 646627 LY6/PLAUR domain containing 8 "GO:0005576,GO:0005615,GO:0005886,GO:0031225,GO:0050829" extracellular region|extracellular space|plasma membrane|anchored component of membrane|defense response to Gram-negative bacterium LYPLA1 3413.524791 3103.735351 3723.31423 1.199623618 0.262581831 0.409207873 1 58.69800083 73.44872261 10434 lysophospholipase 1 "GO:0002084,GO:0004620,GO:0004622,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0006631,GO:0008474,GO:0016298,GO:0018215,GO:0031965,GO:0042997,GO:0050999,GO:0052689,GO:0070062" protein depalmitoylation|phospholipase activity|lysophospholipase activity|protein binding|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|fatty acid metabolic process|palmitoyl-(protein) hydrolase activity|lipase activity|protein phosphopantetheinylation|nuclear membrane|negative regulation of Golgi to plasma membrane protein transport|regulation of nitric-oxide synthase activity|carboxylic ester hydrolase activity|extracellular exosome "hsa00564,hsa05231" Glycerophospholipid metabolism|Choline metabolism in cancer LYPLA2 1306.268121 1266.665049 1345.871193 1.062531247 0.087505268 0.797277314 1 30.60692566 33.92167969 11313 lysophospholipase 2 "GO:0002084,GO:0004622,GO:0005515,GO:0005737,GO:0005795,GO:0005829,GO:0006631,GO:0007411,GO:0008474,GO:0018215,GO:0045296,GO:0046464,GO:0052689,GO:0070062,GO:1905344" protein depalmitoylation|lysophospholipase activity|protein binding|cytoplasm|Golgi stack|cytosol|fatty acid metabolic process|axon guidance|palmitoyl-(protein) hydrolase activity|protein phosphopantetheinylation|cadherin binding|acylglycerol catabolic process|carboxylic ester hydrolase activity|extracellular exosome|prostaglandin catabolic process hsa00564 Glycerophospholipid metabolism LYPLAL1 235.5900347 277.0829794 194.0970901 0.700501671 -0.513539603 0.315640363 1 1.802835999 1.317289793 127018 lysophospholipase like 1 "GO:0002084,GO:0004622,GO:0005515,GO:0005737,GO:0005829,GO:0008150,GO:0008474,GO:0018215,GO:0052689" protein depalmitoylation|lysophospholipase activity|protein binding|cytoplasm|cytosol|biological_process|palmitoyl-(protein) hydrolase activity|protein phosphopantetheinylation|carboxylic ester hydrolase activity LYRM1 171.719316 187.7668541 155.6717778 0.829069532 -0.270434994 0.638289268 1 3.248967804 2.80965045 57149 LYR motif containing 1 "GO:0005654,GO:0030496" nucleoplasm|midbody LYRM2 612.9905975 650.5867757 575.3944193 0.884423786 -0.177190269 0.650896127 1 6.162320003 5.684870695 57226 LYR motif containing 2 GO:0005515 protein binding LYRM4 347.9492723 347.1149412 348.7836035 1.004807233 0.006918754 0.995055661 1 2.449170691 2.56695193 57128 LYR motif containing 4 "GO:0005515,GO:0005739,GO:0005759,GO:0016226,GO:0016604,GO:0044281,GO:1990221" protein binding|mitochondrion|mitochondrial matrix|iron-sulfur cluster assembly|nuclear body|small molecule metabolic process|L-cysteine desulfurase complex LYRM7 265.0737383 272.0081995 258.1392771 0.949012852 -0.07550047 0.885298709 1 2.215188249 2.192798182 90624 LYR motif containing 7 "GO:0005515,GO:0005759,GO:0031966,GO:0034551,GO:0045333" protein binding|mitochondrial matrix|mitochondrial membrane|mitochondrial respiratory chain complex III assembly|cellular respiration LYRM9 72.44118296 69.01700585 75.86536007 1.099227055 0.136489418 0.873280719 1 0.602666874 0.691004156 201229 LYR motif containing 9 LYSMD1 178.541938 182.6920743 174.3918017 0.954566871 -0.067081827 0.91457602 1 3.758208393 3.741994507 388695 LysM domain containing 1 "GO:0005515,GO:0005654" protein binding|nucleoplasm LYSMD2 71.97824231 71.04691779 72.90956682 1.026217169 0.037336067 0.981170247 1 2.275949239 2.436227144 256586 LysM domain containing 2 LYSMD3 772.7679743 830.2339821 715.3019664 0.861566717 -0.214965576 0.562401388 1 8.895371759 7.994088397 116068 LysM domain containing 3 "GO:0005794,GO:0005886,GO:0007030,GO:0016021" Golgi apparatus|plasma membrane|Golgi organization|integral component of membrane LYSMD4 372.4027334 334.9354696 409.8699973 1.223728254 0.291283223 0.512396676 1 2.14426747 2.737031994 145748 LysM domain containing 4 GO:0016021 integral component of membrane LYST 610.2129536 662.7662473 557.6596598 0.841412281 -0.24911522 0.523624339 1 1.999926855 1.755249622 1130 lysosomal trafficking regulator "GO:0005515,GO:0005829,GO:0006909,GO:0007040,GO:0008104,GO:0015031,GO:0015630,GO:0016020,GO:0019901,GO:0030595,GO:0032438,GO:0032510,GO:0033364,GO:0042267,GO:0042742,GO:0042832,GO:0043473,GO:0051607" protein binding|cytosol|phagocytosis|lysosome organization|protein localization|protein transport|microtubule cytoskeleton|membrane|protein kinase binding|leukocyte chemotaxis|melanosome organization|endosome to lysosome transport via multivesicular body sorting pathway|mast cell secretory granule organization|natural killer cell mediated cytotoxicity|defense response to bacterium|defense response to protozoan|pigmentation|defense response to virus LZIC 660.426304 727.7234293 593.1291788 0.815047523 -0.295043913 0.441246495 1 7.067425588 6.008417555 84328 leucine zipper and CTNNBIP1 domain containing "GO:0005515,GO:0008013,GO:0010212" protein binding|beta-catenin binding|response to ionizing radiation LZTFL1 520.0924348 462.8199216 577.3649481 1.247493725 0.319032559 0.431296577 1 4.761364269 6.19563334 54585 leucine zipper transcription factor like 1 "GO:0005515,GO:0005737,GO:0005829,GO:0042802,GO:0044877,GO:1903565,GO:1903568" protein binding|cytoplasm|cytosol|identical protein binding|protein-containing complex binding|negative regulation of protein localization to cilium|negative regulation of protein localization to ciliary membrane LZTR1 1542.962186 1551.867676 1534.056697 0.988522875 -0.016653744 0.961911311 1 18.35511983 18.9260454 8216 leucine zipper like transcription regulator 1 "GO:0005515,GO:0005794,GO:0012505,GO:0016567,GO:0031267,GO:0031463,GO:0046580,GO:0055038" protein binding|Golgi apparatus|endomembrane system|protein ubiquitination|small GTPase binding|Cul3-RING ubiquitin ligase complex|negative regulation of Ras protein signal transduction|recycling endosome membrane LZTS2 4711.377586 4502.344676 4920.410496 1.092855135 0.128102175 0.689458972 1 63.90915765 72.8520237 84445 leucine zipper tumor suppressor 2 "GO:0000281,GO:0005515,GO:0005813,GO:0005829,GO:0005874,GO:0005886,GO:0008285,GO:0016055,GO:0030496,GO:0031982,GO:0051013,GO:0051168,GO:0051255,GO:0060682,GO:0072197,GO:0090090,GO:1900181" mitotic cytokinesis|protein binding|centrosome|cytosol|microtubule|plasma membrane|negative regulation of cell population proliferation|Wnt signaling pathway|midbody|vesicle|microtubule severing|nuclear export|spindle midzone assembly|primary ureteric bud growth|ureter morphogenesis|negative regulation of canonical Wnt signaling pathway|negative regulation of protein localization to nucleus LZTS3 921.2002106 638.4073041 1203.993117 1.885932553 0.915278082 0.010916519 0.445670171 5.333731077 10.49236045 9762 leucine zipper tumor suppressor family member 3 "GO:0005737,GO:0005856,GO:0014069,GO:0043197,GO:0045202,GO:0061001" cytoplasm|cytoskeleton|postsynaptic density|dendritic spine|synapse|regulation of dendritic spine morphogenesis M6PR 3044.726613 3419.386657 2670.066569 0.780861259 -0.356861858 0.262133668 1 66.96824104 54.54547125 4074 "mannose-6-phosphate receptor, cation dependent" "GO:0004888,GO:0005515,GO:0005765,GO:0005768,GO:0005770,GO:0005802,GO:0005886,GO:0005887,GO:0006622,GO:0006898,GO:0007041,GO:0008333,GO:0016020,GO:0019904,GO:0030133,GO:0030665,GO:0032588,GO:0033299,GO:0048471,GO:0061024,GO:1905394" transmembrane signaling receptor activity|protein binding|lysosomal membrane|endosome|late endosome|trans-Golgi network|plasma membrane|integral component of plasma membrane|protein targeting to lysosome|receptor-mediated endocytosis|lysosomal transport|endosome to lysosome transport|membrane|protein domain specific binding|transport vesicle|clathrin-coated vesicle membrane|trans-Golgi network membrane|secretion of lysosomal enzymes|perinuclear region of cytoplasm|membrane organization|retromer complex binding "hsa04142,hsa04145,hsa05132" Lysosome|Phagosome|Salmonella infection MACC1 5.56741205 10.14955968 0.985264417 0.097074597 -3.364762376 0.106651607 1 0.056160755 0.005686623 346389 MET transcriptional regulator MACC1 "GO:0005634,GO:0005737,GO:0005739,GO:0007165,GO:0008083,GO:0045944,GO:0051781" nucleus|cytoplasm|mitochondrion|signal transduction|growth factor activity|positive regulation of transcription by RNA polymerase II|positive regulation of cell division MACF1 7921.3129 7765.428114 8077.197687 1.040148408 0.056789386 0.863793847 1 22.23367851 24.1225136 23499 microtubule actin crosslinking factor 1 "GO:0003723,GO:0003779,GO:0005198,GO:0005509,GO:0005515,GO:0005737,GO:0005794,GO:0005856,GO:0005874,GO:0005882,GO:0005886,GO:0010632,GO:0015629,GO:0016020,GO:0016055,GO:0016887,GO:0030177,GO:0030334,GO:0032587,GO:0032886,GO:0042060,GO:0043001,GO:0045104,GO:0045296,GO:0045773,GO:0051011,GO:0051015,GO:0051893,GO:0150011" RNA binding|actin binding|structural molecule activity|calcium ion binding|protein binding|cytoplasm|Golgi apparatus|cytoskeleton|microtubule|intermediate filament|plasma membrane|regulation of epithelial cell migration|actin cytoskeleton|membrane|Wnt signaling pathway|ATPase activity|positive regulation of Wnt signaling pathway|regulation of cell migration|ruffle membrane|regulation of microtubule-based process|wound healing|Golgi to plasma membrane protein transport|intermediate filament cytoskeleton organization|cadherin binding|positive regulation of axon extension|microtubule minus-end binding|actin filament binding|regulation of focal adhesion assembly|regulation of neuron projection arborization MACIR 319.257838 338.9952934 299.5203826 0.883553219 -0.17861106 0.704312814 1 4.805182118 4.428518826 90355 macrophage immunometabolism regulator "GO:0005515,GO:0005737,GO:0006954,GO:0010764,GO:0015031,GO:0035869,GO:0050728,GO:0060271,GO:1900016" protein binding|cytoplasm|inflammatory response|negative regulation of fibroblast migration|protein transport|ciliary transition zone|negative regulation of inflammatory response|cilium assembly|negative regulation of cytokine production involved in inflammatory response MACO1 365.8446138 391.7730038 339.9162237 0.867635647 -0.204838767 0.648477699 1 5.980084554 5.412035557 55219 macoilin 1 "GO:0003674,GO:0005515,GO:0005634,GO:0006935,GO:0007420,GO:0008017,GO:0016021,GO:0023041,GO:0030424,GO:0030867,GO:0031965,GO:0044306,GO:0045202,GO:0051015" molecular_function|protein binding|nucleus|chemotaxis|brain development|microtubule binding|integral component of membrane|neuronal signal transduction|axon|rough endoplasmic reticulum membrane|nuclear membrane|neuron projection terminus|synapse|actin filament binding MACROD1 246.6775999 327.8307778 165.524422 0.504908121 -0.985907213 0.051196436 1 4.591668246 2.418236588 28992 mono-ADP ribosylhydrolase 1 "GO:0005515,GO:0005634,GO:0005654,GO:0006974,GO:0016798,GO:0019213,GO:0042278,GO:0051725,GO:0140291,GO:0140293" "protein binding|nucleus|nucleoplasm|cellular response to DNA damage stimulus|hydrolase activity, acting on glycosyl bonds|deacetylase activity|purine nucleoside metabolic process|protein de-ADP-ribosylation|peptidyl-glutamate ADP-deribosylation|ADP-ribosylglutamate hydrolase activity" MACROD2 40.40796525 34.50850292 46.30742758 1.341913547 0.424291729 0.653723195 1 0.330259625 0.462270256 140733 mono-ADP ribosylhydrolase 2 "GO:0005634,GO:0005654,GO:0005730,GO:0006974,GO:0016798,GO:0019213,GO:0042278,GO:0051725,GO:0140291,GO:0140293" "nucleus|nucleoplasm|nucleolus|cellular response to DNA damage stimulus|hydrolase activity, acting on glycosyl bonds|deacetylase activity|purine nucleoside metabolic process|protein de-ADP-ribosylation|peptidyl-glutamate ADP-deribosylation|ADP-ribosylglutamate hydrolase activity" MACROH2A1 4818.555402 4588.615933 5048.49487 1.10022171 0.137794277 0.66755822 1 18.24010748 20.93261729 9555 macroH2A.1 histone "GO:0000122,GO:0000182,GO:0000228,GO:0000781,GO:0000785,GO:0000786,GO:0000793,GO:0000976,GO:0000977,GO:0000979,GO:0001739,GO:0001740,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0005730,GO:0006334,GO:0006342,GO:0007549,GO:0010385,GO:0019216,GO:0019899,GO:0019901,GO:0030291,GO:0031490,GO:0031492,GO:0033128,GO:0034184,GO:0040029,GO:0045618,GO:0045814,GO:0045815,GO:0046982,GO:0051572,GO:0061086,GO:0061187,GO:0070062,GO:0071169,GO:0071901,GO:1901837,GO:1902750,GO:1902882,GO:1903226,GO:1904815,GO:1990841" "negative regulation of transcription by RNA polymerase II|rDNA binding|nuclear chromosome|chromosome, telomeric region|chromatin|nucleosome|condensed chromosome|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|sex chromatin|Barr body|DNA binding|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|nucleolus|nucleosome assembly|chromatin silencing|dosage compensation|double-stranded methylated DNA binding|regulation of lipid metabolic process|enzyme binding|protein kinase binding|protein serine/threonine kinase inhibitor activity|chromatin DNA binding|nucleosomal DNA binding|negative regulation of histone phosphorylation|positive regulation of maintenance of mitotic sister chromatid cohesion|regulation of gene expression, epigenetic|positive regulation of keratinocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|negative regulation of histone H3-K4 methylation|negative regulation of histone H3-K27 methylation|regulation of ribosomal DNA heterochromatin assembly|extracellular exosome|establishment of protein localization to chromatin|negative regulation of protein serine/threonine kinase activity|negative regulation of transcription of nucleolar large rRNA by RNA polymerase I|negative regulation of cell cycle G2/M phase transition|regulation of response to oxidative stress|positive regulation of endodermal cell differentiation|negative regulation of protein localization to chromosome, telomeric region|promoter-specific chromatin binding" "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus MACROH2A2 197.4279871 160.363043 234.4929311 1.462262918 0.548202734 0.312060735 1 4.203841823 6.411915094 55506 macroH2A.2 histone "GO:0000122,GO:0000781,GO:0000785,GO:0000786,GO:0000976,GO:0000977,GO:0001740,GO:0003677,GO:0005515,GO:0005654,GO:0006334,GO:0006342,GO:0007420,GO:0007549,GO:0031490,GO:0045618,GO:0045814,GO:0046982,GO:0070062,GO:0071169,GO:1901837" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|chromatin|nucleosome|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|Barr body|DNA binding|protein binding|nucleoplasm|nucleosome assembly|chromatin silencing|brain development|dosage compensation|chromatin DNA binding|positive regulation of keratinocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|extracellular exosome|establishment of protein localization to chromatin|negative regulation of transcription of nucleolar large rRNA by RNA polymerase I" "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus MAD1L1 696.7920128 721.6336935 671.9503321 0.93115155 -0.102912102 0.788340919 1 10.89365151 10.58058738 8379 mitotic arrest deficient 1 like 1 "GO:0000776,GO:0000777,GO:0005515,GO:0005635,GO:0005813,GO:0005819,GO:0005829,GO:0007094,GO:0042130,GO:0042802,GO:0043515,GO:0044615,GO:0048538,GO:0051301,GO:0051315,GO:0072686,GO:0090235,GO:0097431" kinetochore|condensed chromosome kinetochore|protein binding|nuclear envelope|centrosome|spindle|cytosol|mitotic spindle assembly checkpoint|negative regulation of T cell proliferation|identical protein binding|kinetochore binding|nuclear pore nuclear basket|thymus development|cell division|attachment of mitotic spindle microtubules to kinetochore|mitotic spindle|regulation of metaphase plate congression|mitotic spindle pole "hsa04110,hsa04114,hsa04914,hsa05166,hsa05203" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection|Viral carcinogenesis MAD2L1 1184.744588 1176.333967 1193.155208 1.014299716 0.020484017 0.954968833 1 11.39796548 12.05895212 4085 mitotic arrest deficient 2 like 1 "GO:0000132,GO:0000776,GO:0000777,GO:0000922,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0007094,GO:0008022,GO:0031145,GO:0042177,GO:0042802,GO:0042803,GO:0043066,GO:0044615,GO:0045930,GO:0048471,GO:0051301,GO:0051660,GO:0072686,GO:0090267,GO:1901990,GO:1904667" establishment of mitotic spindle orientation|kinetochore|condensed chromosome kinetochore|spindle pole|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|mitotic spindle assembly checkpoint|protein C-terminus binding|anaphase-promoting complex-dependent catabolic process|negative regulation of protein catabolic process|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|nuclear pore nuclear basket|negative regulation of mitotic cell cycle|perinuclear region of cytoplasm|cell division|establishment of centrosome localization|mitotic spindle|positive regulation of mitotic cell cycle spindle assembly checkpoint|regulation of mitotic cell cycle phase transition|negative regulation of ubiquitin protein ligase activity "hsa04110,hsa04114,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection MAD2L1BP 372.0558374 378.5785762 365.5330985 0.965540898 -0.050590725 0.915129868 1 11.82829694 11.91266208 9587 MAD2L1 binding protein "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005819,GO:0007093,GO:0007096,GO:0031965,GO:1902426" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|spindle|mitotic cell cycle checkpoint|regulation of exit from mitosis|nuclear membrane|deactivation of mitotic spindle assembly checkpoint MAD2L2 1352.791554 1180.393791 1525.189317 1.292102117 0.369720093 0.271431564 1 49.81898445 67.14406618 10459 mitotic arrest deficient 2 like 2 "GO:0000122,GO:0001102,GO:0001558,GO:0005515,GO:0005634,GO:0005654,GO:0005680,GO:0005694,GO:0005730,GO:0005819,GO:0005829,GO:0006302,GO:0007015,GO:0007094,GO:0008432,GO:0010719,GO:0010944,GO:0016035,GO:0033138,GO:0035861,GO:0042177,GO:0042276,GO:0042772,GO:0043433,GO:0045830,GO:0045893,GO:0051301,GO:0090090,GO:1904667,GO:2000042,GO:2000048,GO:2000678,GO:2001034" "negative regulation of transcription by RNA polymerase II|RNA polymerase II activating transcription factor binding|regulation of cell growth|protein binding|nucleus|nucleoplasm|anaphase-promoting complex|chromosome|nucleolus|spindle|cytosol|double-strand break repair|actin filament organization|mitotic spindle assembly checkpoint|JUN kinase binding|negative regulation of epithelial to mesenchymal transition|negative regulation of transcription by competitive promoter binding|zeta DNA polymerase complex|positive regulation of peptidyl-serine phosphorylation|site of double-strand break|negative regulation of protein catabolic process|error-prone translesion synthesis|DNA damage response, signal transduction resulting in transcription|negative regulation of DNA-binding transcription factor activity|positive regulation of isotype switching|positive regulation of transcription, DNA-templated|cell division|negative regulation of canonical Wnt signaling pathway|negative regulation of ubiquitin protein ligase activity|negative regulation of double-strand break repair via homologous recombination|negative regulation of cell-cell adhesion mediated by cadherin|negative regulation of transcription regulatory region DNA binding|positive regulation of double-strand break repair via nonhomologous end joining" "hsa04110,hsa04114,hsa04914,hsa05100" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Bacterial invasion of epithelial cells MADD 1949.047502 1831.995523 2066.099481 1.127786316 0.173493743 0.591557864 1 13.90024125 16.35178199 8567 MAP kinase activating death domain "GO:0000187,GO:0005085,GO:0005123,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007166,GO:0010803,GO:0016021,GO:0030295,GO:0032483,GO:0042981,GO:0045202,GO:0051726,GO:0097194,GO:1902041,GO:2001236" activation of MAPK activity|guanyl-nucleotide exchange factor activity|death receptor binding|protein binding|cytoplasm|cytosol|plasma membrane|cell surface receptor signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway|integral component of membrane|protein kinase activator activity|regulation of Rab protein signal transduction|regulation of apoptotic process|synapse|regulation of cell cycle|execution phase of apoptosis|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of extrinsic apoptotic signaling pathway MAEA 1517.098376 1467.62633 1566.570422 1.067417768 0.094124932 0.777580329 1 26.3301793 29.31596362 10296 "macrophage erythroblast attacher, E3 ubiquitin ligase" "GO:0000151,GO:0003779,GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005826,GO:0005856,GO:0005887,GO:0007049,GO:0007155,GO:0007346,GO:0016363,GO:0016567,GO:0033033,GO:0034657,GO:0043161,GO:0043249,GO:0045721,GO:0046872,GO:0051301" ubiquitin ligase complex|actin binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|spindle|actomyosin contractile ring|cytoskeleton|integral component of plasma membrane|cell cycle|cell adhesion|regulation of mitotic cell cycle|nuclear matrix|protein ubiquitination|negative regulation of myeloid cell apoptotic process|GID complex|proteasome-mediated ubiquitin-dependent protein catabolic process|erythrocyte maturation|negative regulation of gluconeogenesis|metal ion binding|cell division MAF 6.971079795 5.074779842 8.867379749 1.747342747 0.805162625 0.671092798 1 0.007932462 0.014457794 4094 MAF bZIP transcription factor "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0006366,GO:0032330,GO:0045944,GO:0048468,GO:0048839,GO:0070306,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|regulation of chondrocyte differentiation|positive regulation of transcription by RNA polymerase II|cell development|inner ear development|lens fiber cell differentiation|sequence-specific double-stranded DNA binding" "hsa04658,hsa05202,hsa05321" Th1 and Th2 cell differentiation|Transcriptional misregulation in cancer|Inflammatory bowel disease TF_bZIP MAF1 4953.941914 4010.091031 5897.792797 1.470737884 0.556540151 0.083577133 1 118.4238857 181.6730536 84232 "MAF1 homolog, negative regulator of RNA polymerase III" "GO:0000994,GO:0001002,GO:0001003,GO:0001006,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0016479,GO:0016480,GO:0043231" RNA polymerase III core binding|RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 3 promoter sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|negative regulation of transcription by RNA polymerase I|negative regulation of transcription by RNA polymerase III|intracellular membrane-bounded organelle MAFA 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.0770385 0.07800624 389692 MAF bZIP transcription factor A "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0007263,GO:0009749,GO:0030073,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nitric oxide mediated signal transduction|response to glucose|insulin secretion|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa04930,hsa04950" Type II diabetes mellitus|Maturity onset diabetes of the young MAFF 1501.618937 1453.416947 1549.820927 1.066329198 0.092652897 0.781289553 1 30.13116701 33.51376218 23764 MAF bZIP transcription factor F "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001701,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0007567,GO:0007596,GO:0035914,GO:0043565,GO:0045604,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|parturition|blood coagulation|skeletal muscle cell differentiation|sequence-specific DNA binding|regulation of epidermal cell differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TF_bZIP MAFG 1890.13824 1677.722216 2102.554265 1.253219541 0.32563917 0.314473398 1 16.41946117 21.46357147 4097 MAF bZIP transcription factor G "GO:0000978,GO:0000981,GO:0001228,GO:0001701,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007596,GO:0030534,GO:0030641,GO:0042127,GO:0045604,GO:0045944,GO:0046982,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|blood coagulation|adult behavior|regulation of cellular pH|regulation of cell population proliferation|regulation of epidermal cell differentiation|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|sequence-specific double-stranded DNA binding" TF_bZIP MAFK 818.7191032 805.8750389 831.5631676 1.031876069 0.04526971 0.904742467 1 10.7153394 11.53318881 7975 MAF bZIP transcription factor K "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001221,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007399,GO:0007596,GO:0043565,GO:0071535" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription coregulator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nervous system development|blood coagulation|sequence-specific DNA binding|RING-like zinc finger domain binding" TF_bZIP MAGEA10 36.10788736 43.64310664 28.57266808 0.654689143 -0.611118041 0.523020943 1 0.805821869 0.550288096 4109 MAGE family member A10 "GO:0005654,GO:0005829" nucleoplasm|cytosol MAGEA12 646.8431647 708.4392659 585.2470634 0.826107602 -0.275598387 0.474192578 1 18.25951633 15.73409682 4111 MAGE family member A12 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process MAGEA2B 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.02438517 0.074074474 266740 MAGE family member A2B "GO:0000122,GO:0005515,GO:0005634,GO:0016605,GO:0031625,GO:0033234,GO:0042826,GO:0044257,GO:0051443,GO:0070491,GO:0072331,GO:0090398,GO:1901984" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|PML body|ubiquitin protein ligase binding|negative regulation of protein sumoylation|histone deacetylase binding|cellular protein catabolic process|positive regulation of ubiquitin-protein transferase activity|repressing transcription factor binding|signal transduction by p53 class mediator|cellular senescence|negative regulation of protein acetylation MAGEA3 715.4835829 888.0864723 542.8806935 0.611292605 -0.710064979 0.059426585 1 17.47414407 11.14194433 4102 MAGE family member A3 "GO:0005515,GO:0005783,GO:0010955,GO:0043154,GO:0089720,GO:1902236" protein binding|endoplasmic reticulum|negative regulation of protein processing|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|caspase binding|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway MAGEA6 61.28879148 81.19647747 41.38110549 0.509641635 -0.972444953 0.223027936 1 2.355277858 1.252053766 4105 MAGE family member A6 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process MAGEB2 15.62789708 24.35894324 6.896850916 0.283134241 -1.82044186 0.139083532 1 0.745885455 0.220282736 4113 MAGE family member B2 GO:0005515 protein binding MAGED1 7179.297701 8397.745682 5960.84972 0.709815461 -0.494484096 0.132401771 1 110.9038314 82.11224653 9500 MAGE family member D1 "GO:0000785,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0006355,GO:0032922,GO:0032991,GO:0042802,GO:0042981,GO:0050680" "chromatin|protein binding|nucleus|cytoplasm|plasma membrane|regulation of transcription, DNA-templated|circadian regulation of gene expression|protein-containing complex|identical protein binding|regulation of apoptotic process|negative regulation of epithelial cell proliferation" hsa04722 Neurotrophin signaling pathway MAGED2 3968.313034 4086.212729 3850.41334 0.942293903 -0.085750986 0.788370111 1 90.68898309 89.13675976 10916 MAGE family member D2 "GO:0002576,GO:0005515,GO:0005576,GO:0005654,GO:0005730,GO:0005829,GO:0007565,GO:0016020,GO:0031093,GO:0070294" platelet degranulation|protein binding|extracellular region|nucleoplasm|nucleolus|cytosol|female pregnancy|membrane|platelet alpha granule lumen|renal sodium ion absorption MAGEE1 323.3406725 247.6492563 399.0320887 1.611279172 0.688206479 0.136773677 1 3.452397792 5.802398514 57692 MAGE family member E1 "GO:0005515,GO:0005634,GO:0005886,GO:0008150,GO:0030425,GO:0045211,GO:0048471" protein binding|nucleus|plasma membrane|biological_process|dendrite|postsynaptic membrane|perinuclear region of cytoplasm MAGEF1 1163.975847 1036.270044 1291.68165 1.246472054 0.317850538 0.355265333 1 30.85445148 40.11587838 64110 MAGE family member F1 "GO:0005515,GO:0016567,GO:0097428,GO:2000042,GO:2000060" protein binding|protein ubiquitination|protein maturation by iron-sulfur cluster transfer|negative regulation of double-strand break repair via homologous recombination|positive regulation of ubiquitin-dependent protein catabolic process MAGEH1 151.0611764 156.3032191 145.8191336 0.932924699 -0.100167456 0.875858343 1 5.497365725 5.34954877 28986 MAGE family member H1 "GO:0005515,GO:0005737,GO:0006915" protein binding|cytoplasm|apoptotic process MAGI1 504.6087901 684.0803227 325.1372575 0.475291054 -1.073116848 0.00898379 0.397929068 3.479587733 1.725056646 9223 "membrane associated guanylate kinase, WW and PDZ domain containing 1" "GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005886,GO:0005911,GO:0005912,GO:0005923,GO:0007155,GO:0007165,GO:0007166,GO:0008022,GO:0022409,GO:0030054,GO:0042995,GO:0051393,GO:0060090,GO:0065003,GO:0071944" protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|plasma membrane|cell-cell junction|adherens junction|bicellular tight junction|cell adhesion|signal transduction|cell surface receptor signaling pathway|protein C-terminus binding|positive regulation of cell-cell adhesion|cell junction|cell projection|alpha-actinin binding|molecular adaptor activity|protein-containing complex assembly|cell periphery "hsa04015,hsa04151,hsa04530,hsa05165" Rap1 signaling pathway|PI3K-Akt signaling pathway|Tight junction|Human papillomavirus infection MAGI2 68.79976242 55.82257826 81.77694657 1.464943919 0.550845437 0.477388104 1 0.082517561 0.126090774 9863 "membrane associated guanylate kinase, WW and PDZ domain containing 2" "GO:0002092,GO:0003402,GO:0005515,GO:0005634,GO:0005737,GO:0005770,GO:0005886,GO:0005911,GO:0005923,GO:0007165,GO:0007399,GO:0008285,GO:0010976,GO:0014069,GO:0019902,GO:0030159,GO:0030336,GO:0030425,GO:0031697,GO:0032516,GO:0032926,GO:0032991,GO:0036057,GO:0038180,GO:0043113,GO:0045202,GO:0046332,GO:0048471,GO:0051898,GO:0060395,GO:0070699,GO:0071850,GO:0072015,GO:1990090" positive regulation of receptor internalization|planar cell polarity pathway involved in axis elongation|protein binding|nucleus|cytoplasm|late endosome|plasma membrane|cell-cell junction|bicellular tight junction|signal transduction|nervous system development|negative regulation of cell population proliferation|positive regulation of neuron projection development|postsynaptic density|phosphatase binding|signaling receptor complex adaptor activity|negative regulation of cell migration|dendrite|beta-1 adrenergic receptor binding|positive regulation of phosphoprotein phosphatase activity|negative regulation of activin receptor signaling pathway|protein-containing complex|slit diaphragm|nerve growth factor signaling pathway|receptor clustering|synapse|SMAD binding|perinuclear region of cytoplasm|negative regulation of protein kinase B signaling|SMAD protein signal transduction|type II activin receptor binding|mitotic cell cycle arrest|glomerular visceral epithelial cell development|cellular response to nerve growth factor stimulus "hsa04015,hsa04151" Rap1 signaling pathway|PI3K-Akt signaling pathway MAGI3 411.4070309 374.5187523 448.2953095 1.196990289 0.259411448 0.548550369 1 2.611600383 3.260718296 260425 "membrane associated guanylate kinase, WW and PDZ domain containing 3" "GO:0004385,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0005911,GO:0005923,GO:0006915,GO:0007165,GO:0016020,GO:0016032,GO:0030054,GO:0035556,GO:0046037,GO:0046328,GO:0046710,GO:0060090" guanylate kinase activity|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|cell-cell junction|bicellular tight junction|apoptotic process|signal transduction|membrane|viral process|cell junction|intracellular signal transduction|GMP metabolic process|regulation of JNK cascade|GDP metabolic process|molecular adaptor activity hsa04015 Rap1 signaling pathway MAGIX 19.04663098 22.3290313 15.76423066 0.705997069 -0.5022659 0.683916782 1 0.40245077 0.296368192 79917 "MAGI family member, X-linked" MAGOH 944.5399924 920.5650633 968.5149215 1.052087419 0.073254585 0.839472154 1 71.07221478 77.99515156 4116 "mago homolog, exon junction complex subunit" "GO:0000184,GO:0000381,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006405,GO:0006406,GO:0006417,GO:0008380,GO:0016607,GO:0031124,GO:0035145,GO:0071013" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|RNA export from nucleus|mRNA export from nucleus|regulation of translation|RNA splicing|nuclear speck|mRNA 3'-end processing|exon-exon junction complex|catalytic step 2 spliceosome" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome MAGOHB 434.7928339 457.7451417 411.8405261 0.899715778 -0.152458772 0.722509445 1 7.864035482 7.380176197 55110 "mago homolog B, exon junction complex subunit" "GO:0000184,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006405,GO:0006406,GO:0008380,GO:0031124,GO:0035145,GO:0043025,GO:0071005,GO:0071006,GO:0071013" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|RNA splicing|mRNA 3'-end processing|exon-exon junction complex|neuronal cell body|U2-type precatalytic spliceosome|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome MAGT1 2978.814104 2921.043277 3036.584932 1.039554927 0.055965989 0.86125825 1 31.89060943 34.58009561 84061 magnesium transporter 1 "GO:0005783,GO:0005886,GO:0005887,GO:0006487,GO:0008250,GO:0015095,GO:0015693,GO:0016020,GO:0018279,GO:0035577,GO:0043312,GO:0050890,GO:0055085,GO:1903830" endoplasmic reticulum|plasma membrane|integral component of plasma membrane|protein N-linked glycosylation|oligosaccharyltransferase complex|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|protein N-linked glycosylation via asparagine|azurophil granule membrane|neutrophil degranulation|cognition|transmembrane transport|magnesium ion transmembrane transport MAIP1 266.2223063 283.1727152 249.2718974 0.880282188 -0.183962018 0.712876839 1 9.535704156 8.755694759 79568 matrix AAA peptidase interacting protein 1 "GO:0005515,GO:0005743,GO:0005759,GO:0006851,GO:0007007,GO:0032979,GO:0036444,GO:0043022,GO:0051204,GO:0051560" protein binding|mitochondrial inner membrane|mitochondrial matrix|mitochondrial calcium ion transmembrane transport|inner mitochondrial membrane organization|protein insertion into mitochondrial inner membrane from matrix|calcium import into the mitochondrion|ribosome binding|protein insertion into mitochondrial membrane|mitochondrial calcium ion homeostasis MAK 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.029103433 0.029469024 4117 male germ cell associated kinase "GO:0000165,GO:0001750,GO:0001917,GO:0003713,GO:0004672,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005929,GO:0005930,GO:0006468,GO:0007275,GO:0007283,GO:0010468,GO:0030154,GO:0030496,GO:0031514,GO:0032391,GO:0035556,GO:0042073,GO:0045494,GO:0045893,GO:0046777,GO:0046872,GO:0060271,GO:0072686,GO:0106310,GO:0106311,GO:1902856" "MAPK cascade|photoreceptor outer segment|photoreceptor inner segment|transcription coactivator activity|protein kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cilium|axoneme|protein phosphorylation|multicellular organism development|spermatogenesis|regulation of gene expression|cell differentiation|midbody|motile cilium|photoreceptor connecting cilium|intracellular signal transduction|intraciliary transport|photoreceptor cell maintenance|positive regulation of transcription, DNA-templated|protein autophosphorylation|metal ion binding|cilium assembly|mitotic spindle|protein serine kinase activity|protein threonine kinase activity|negative regulation of non-motile cilium assembly" MAK16 357.1702291 404.9674314 309.3730268 0.76394545 -0.388458469 0.38695762 1 5.759666318 4.589608089 84549 MAK16 homolog "GO:0000460,GO:0000470,GO:0003723,GO:0005515,GO:0005730,GO:0030687,GO:0043231" "maturation of 5.8S rRNA|maturation of LSU-rRNA|RNA binding|protein binding|nucleolus|preribosome, large subunit precursor|intracellular membrane-bounded organelle" MAL 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.142261824 0 4118 "mal, T cell differentiation protein" "GO:0001766,GO:0005515,GO:0005783,GO:0006915,GO:0007417,GO:0008289,GO:0016021,GO:0016324,GO:0016505,GO:0019898,GO:0019911,GO:0030154,GO:0042552,GO:0045121,GO:0045176" membrane raft polarization|protein binding|endoplasmic reticulum|apoptotic process|central nervous system development|lipid binding|integral component of membrane|apical plasma membrane|peptidase activator activity involved in apoptotic process|extrinsic component of membrane|structural constituent of myelin sheath|cell differentiation|myelination|membrane raft|apical protein localization MAL2 130.0885539 137.0190557 123.1580521 0.898838862 -0.153865594 0.814473103 1 2.455602193 2.302267503 114569 "mal, T cell differentiation protein 2" "GO:0005515,GO:0012505,GO:0016021,GO:0016324,GO:0019911,GO:0042552,GO:0045056,GO:0045121,GO:0048471,GO:0070062" protein binding|endomembrane system|integral component of membrane|apical plasma membrane|structural constituent of myelin sheath|myelination|transcytosis|membrane raft|perinuclear region of cytoplasm|extracellular exosome MALL 122.0849508 162.3929549 81.77694657 0.503574472 -0.989722945 0.119853259 1 3.370750115 1.770541839 7851 "mal, T cell differentiation protein like" "GO:0000139,GO:0005515,GO:0005886,GO:0016021,GO:0019911,GO:0030136,GO:0031410,GO:0042552,GO:0042632,GO:0045121" Golgi membrane|protein binding|plasma membrane|integral component of membrane|structural constituent of myelin sheath|clathrin-coated vesicle|cytoplasmic vesicle|myelination|cholesterol homeostasis|membrane raft MALSU1 495.9655808 497.3284245 494.6027371 0.994519341 -0.007928666 0.990135674 1 7.607348303 7.891552758 115416 mitochondrial assembly of ribosomal large subunit 1 "GO:0005515,GO:0005739,GO:0005762,GO:0005829,GO:0017148,GO:0042273,GO:0043023,GO:0070130,GO:0090071" protein binding|mitochondrion|mitochondrial large ribosomal subunit|cytosol|negative regulation of translation|ribosomal large subunit biogenesis|ribosomal large subunit binding|negative regulation of mitochondrial translation|negative regulation of ribosome biogenesis MALT1 1527.310041 1458.491727 1596.128355 1.094369153 0.13009947 0.695181016 1 7.859912822 8.972170164 10892 MALT1 paracaspase "GO:0001650,GO:0001923,GO:0002020,GO:0002096,GO:0002223,GO:0002726,GO:0004197,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0006952,GO:0007250,GO:0008233,GO:0009620,GO:0016567,GO:0019209,GO:0031398,GO:0031663,GO:0032449,GO:0032731,GO:0032743,GO:0032991,GO:0038095,GO:0042098,GO:0042113,GO:0042802,GO:0042981,GO:0043066,GO:0043123,GO:0043280,GO:0043621,GO:0045087,GO:0048471,GO:0050852,GO:0050856,GO:0051092,GO:0051168,GO:2000321" fibrillar center|B-1 B cell differentiation|protease binding|polkadots|stimulatory C-type lectin receptor signaling pathway|positive regulation of T cell cytokine production|cysteine-type endopeptidase activity|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|proteolysis|defense response|activation of NF-kappaB-inducing kinase activity|peptidase activity|response to fungus|protein ubiquitination|kinase activator activity|positive regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|CBM complex|positive regulation of interleukin-1 beta production|positive regulation of interleukin-2 production|protein-containing complex|Fc-epsilon receptor signaling pathway|T cell proliferation|B cell activation|identical protein binding|regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein self-association|innate immune response|perinuclear region of cytoplasm|T cell receptor signaling pathway|regulation of T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|nuclear export|positive regulation of T-helper 17 cell differentiation "hsa04064,hsa04625,hsa04660,hsa04662,hsa05131,hsa05152" NF-kappa B signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Shigellosis|Tuberculosis MAMDC2 576.689715 593.7492415 559.6301886 0.942536259 -0.085379976 0.832419311 1 5.837954661 5.739508636 256691 MAM domain containing 2 "GO:0005515,GO:0005576,GO:0005783,GO:0016020" protein binding|extracellular region|endoplasmic reticulum|membrane MAMDC4 50.09458428 56.83753423 43.35163433 0.762728977 -0.390757585 0.657319981 1 0.782021352 0.622163869 158056 MAM domain containing 4 "GO:0015031,GO:0016021" protein transport|integral component of membrane MAML1 1576.416639 1548.822808 1604.01047 1.035632005 0.050511456 0.879940886 1 13.64690524 14.74197156 9794 mastermind like transcriptional coactivator 1 "GO:0002193,GO:0003162,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006367,GO:0006468,GO:0007219,GO:0007221,GO:0010831,GO:0016607,GO:0019901,GO:0042605,GO:0043231,GO:0045445,GO:0045747,GO:0045944,GO:0060928" MAML1-RBP-Jkappa- ICN1 complex|atrioventricular node development|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|protein phosphorylation|Notch signaling pathway|positive regulation of transcription of Notch receptor target|positive regulation of myotube differentiation|nuclear speck|protein kinase binding|peptide antigen binding|intracellular membrane-bounded organelle|myoblast differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|atrioventricular node cell development "hsa04330,hsa04658,hsa05165" Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection MAML2 413.5678332 421.2067269 405.9289396 0.96372853 -0.05330128 0.906818445 1 1.989427846 1.999856518 84441 mastermind like transcriptional coactivator 2 "GO:0003713,GO:0005634,GO:0005654,GO:0006367,GO:0007219,GO:0007221,GO:0016607,GO:0045747,GO:0045944" transcription coactivator activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|positive regulation of transcription of Notch receptor target|nuclear speck|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II "hsa04330,hsa04658,hsa05165" Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection MAML3 133.6827155 180.6621624 86.70326866 0.479919356 -1.059136094 0.086631032 1 1.336923025 0.66925342 55534 mastermind like transcriptional coactivator 3 "GO:0003713,GO:0005634,GO:0005654,GO:0006367,GO:0007219,GO:0007221,GO:0016607,GO:0045747,GO:0045944" transcription coactivator activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|positive regulation of transcription of Notch receptor target|nuclear speck|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II "hsa04330,hsa04658,hsa05165" Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection other MAMLD1 527.3819569 590.7043736 464.0595402 0.785603698 -0.348126375 0.388542378 1 5.633043239 4.615965281 10046 mastermind like domain containing 1 "GO:0003674,GO:0005654,GO:0005794,GO:0005813,GO:0006357,GO:0008584,GO:0016604" molecular_function|nucleoplasm|Golgi apparatus|centrosome|regulation of transcription by RNA polymerase II|male gonad development|nuclear body MAMSTR 14.98680711 14.20938356 15.76423066 1.109423966 0.149810797 0.961565511 1 0.245699949 0.284327286 284358 MEF2 activating motif and SAP domain containing transcriptional regulator "GO:0001085,GO:0003712,GO:0005634,GO:0006357,GO:0010831,GO:0045944,GO:0051059" RNA polymerase II transcription factor binding|transcription coregulator activity|nucleus|regulation of transcription by RNA polymerase II|positive regulation of myotube differentiation|positive regulation of transcription by RNA polymerase II|NF-kappaB binding MAN1A1 280.9000737 242.5744764 319.225671 1.315990353 0.396148914 0.413289421 1 2.31846414 3.182504443 4121 mannosidase alpha class 1A member 1 "GO:0000139,GO:0004571,GO:0005509,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0005975,GO:0006486,GO:0006491,GO:0015923,GO:0016020,GO:0016021,GO:0030433,GO:0031410,GO:0045047,GO:0070062,GO:1904381,GO:1904382" "Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|carbohydrate metabolic process|protein glycosylation|N-glycan processing|mannosidase activity|membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|protein targeting to ER|extracellular exosome|Golgi apparatus mannose trimming|mannose trimming involved in glycoprotein ERAD pathway" "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum MAN1A2 1372.186319 1327.562407 1416.810231 1.067226839 0.093866854 0.781153281 1 7.668379623 8.536429791 10905 mannosidase alpha class 1A member 2 "GO:0000139,GO:0004571,GO:0005509,GO:0005783,GO:0005794,GO:0005975,GO:0006486,GO:0006491,GO:0007585,GO:0016020,GO:0016021,GO:0048286,GO:0070062,GO:1904381" "Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|Golgi apparatus|carbohydrate metabolic process|protein glycosylation|N-glycan processing|respiratory gaseous exchange by respiratory system|membrane|integral component of membrane|lung alveolus development|extracellular exosome|Golgi apparatus mannose trimming" "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum MAN1B1 1840.09735 2062.390528 1617.804172 0.784431537 -0.350280556 0.280332734 1 29.15233172 23.85306944 11253 mannosidase alpha class 1B member 1 "GO:0004571,GO:0005509,GO:0005783,GO:0005789,GO:0005794,GO:0006486,GO:0006491,GO:0009311,GO:0016020,GO:0016021,GO:0030433,GO:0031410,GO:0036508,GO:0036509,GO:0036510,GO:0036511,GO:0036512,GO:0044322,GO:1903561,GO:1904380,GO:1904382" "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein glycosylation|N-glycan processing|oligosaccharide metabolic process|membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|protein alpha-1,2-demannosylation|trimming of terminal mannose on B branch|trimming of terminal mannose on C branch|trimming of first mannose on A branch|trimming of second mannose on A branch|endoplasmic reticulum quality control compartment|extracellular vesicle|endoplasmic reticulum mannose trimming|mannose trimming involved in glycoprotein ERAD pathway" "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum MAN1C1 27.40653275 21.31407534 33.49899016 1.571683952 0.652311137 0.532667534 1 0.268194466 0.439674178 57134 mannosidase alpha class 1C member 1 "GO:0000139,GO:0004571,GO:0005509,GO:0005515,GO:0005783,GO:0005975,GO:0006487,GO:0006491,GO:0030173,GO:0070062,GO:1904381" "Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|protein binding|endoplasmic reticulum|carbohydrate metabolic process|protein N-linked glycosylation|N-glycan processing|integral component of Golgi membrane|extracellular exosome|Golgi apparatus mannose trimming" "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum MAN2A1 1141.12573 1158.06476 1124.186699 0.970745971 -0.042834281 0.903579183 1 11.8680483 12.01713199 4124 mannosidase alpha class 2A member 1 "GO:0000139,GO:0001701,GO:0001889,GO:0004559,GO:0004572,GO:0005797,GO:0005801,GO:0006013,GO:0006486,GO:0006491,GO:0006517,GO:0007005,GO:0007033,GO:0007585,GO:0016020,GO:0016021,GO:0016799,GO:0030246,GO:0042803,GO:0046872,GO:0048286,GO:0050769,GO:0060042,GO:0070062" "Golgi membrane|in utero embryonic development|liver development|alpha-mannosidase activity|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|Golgi medial cisterna|cis-Golgi network|mannose metabolic process|protein glycosylation|N-glycan processing|protein deglycosylation|mitochondrion organization|vacuole organization|respiratory gaseous exchange by respiratory system|membrane|integral component of membrane|hydrolase activity, hydrolyzing N-glycosyl compounds|carbohydrate binding|protein homodimerization activity|metal ion binding|lung alveolus development|positive regulation of neurogenesis|retina morphogenesis in camera-type eye|extracellular exosome" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MAN2A2 2189.549013 2108.063546 2271.03448 1.077308359 0.107431253 0.738336065 1 18.57122662 20.86875541 4122 mannosidase alpha class 2A member 2 "GO:0000139,GO:0004559,GO:0004572,GO:0006013,GO:0006486,GO:0006491,GO:0006517,GO:0016021,GO:0016799,GO:0030246,GO:0046872" "Golgi membrane|alpha-mannosidase activity|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|mannose metabolic process|protein glycosylation|N-glycan processing|protein deglycosylation|integral component of membrane|hydrolase activity, hydrolyzing N-glycosyl compounds|carbohydrate binding|metal ion binding" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MAN2B1 2787.487977 2807.368209 2767.607746 0.985837105 -0.020578813 0.949640543 1 44.62752541 45.89061687 4125 mannosidase alpha class 2B member 1 "GO:0004559,GO:0005576,GO:0005615,GO:0005654,GO:0005764,GO:0005774,GO:0006013,GO:0006464,GO:0006517,GO:0009313,GO:0030246,GO:0035578,GO:0043202,GO:0043231,GO:0043312,GO:0046872,GO:0070062" alpha-mannosidase activity|extracellular region|extracellular space|nucleoplasm|lysosome|vacuolar membrane|mannose metabolic process|cellular protein modification process|protein deglycosylation|oligosaccharide catabolic process|carbohydrate binding|azurophil granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|metal ion binding|extracellular exosome "hsa00511,hsa04142" Other glycan degradation|Lysosome MAN2B2 633.5299709 673.930763 593.1291788 0.880104027 -0.184254036 0.635169783 1 6.741500229 6.188800622 23324 mannosidase alpha class 2B member 2 "GO:0004559,GO:0005515,GO:0005764,GO:0005774,GO:0006013,GO:0009313,GO:0030246,GO:0043202,GO:0046872,GO:0070062" alpha-mannosidase activity|protein binding|lysosome|vacuolar membrane|mannose metabolic process|oligosaccharide catabolic process|carbohydrate binding|lysosomal lumen|metal ion binding|extracellular exosome hsa00511 Other glycan degradation MAN2C1 897.9707841 835.308762 960.6328061 1.150033197 0.201675507 0.575689093 1 12.77338225 15.32259122 4123 mannosidase alpha class 2C member 1 "GO:0004559,GO:0005654,GO:0005829,GO:0006013,GO:0009313,GO:0030246,GO:0046872" alpha-mannosidase activity|nucleoplasm|cytosol|mannose metabolic process|oligosaccharide catabolic process|carbohydrate binding|metal ion binding hsa00511 Other glycan degradation MANBA 621.4395739 655.6615556 587.2175923 0.895610833 -0.159056115 0.684050829 1 4.405857072 4.115908129 4126 mannosidase beta "GO:0004567,GO:0005764,GO:0005886,GO:0006464,GO:0006516,GO:0009313,GO:0035577,GO:0043202,GO:0043312" beta-mannosidase activity|lysosome|plasma membrane|cellular protein modification process|glycoprotein catabolic process|oligosaccharide catabolic process|azurophil granule membrane|lysosomal lumen|neutrophil degranulation "hsa00511,hsa04142" Other glycan degradation|Lysosome MANBAL 1682.517394 1662.497876 1702.536912 1.024083661 0.034333579 0.918224344 1 17.60762285 18.80841047 63905 mannosidase beta like "GO:0005515,GO:0016021" protein binding|integral component of membrane MANEA 310.6037424 286.2175831 334.9899016 1.170402943 0.227005302 0.630857053 1 2.835108717 3.461155028 79694 mannosidase endo-alpha "GO:0000139,GO:0004559,GO:0004569,GO:0005794,GO:0016021" "Golgi membrane|alpha-mannosidase activity|glycoprotein endo-alpha-1,2-mannosidase activity|Golgi apparatus|integral component of membrane" MANEAL 679.4635325 682.0504107 676.8766542 0.992414407 -0.010985415 0.981275248 1 11.82994766 12.24593115 149175 mannosidase endo-alpha like "GO:0000139,GO:0004559,GO:0005794,GO:0016021" Golgi membrane|alpha-mannosidase activity|Golgi apparatus|integral component of membrane MANF 3017.642974 2914.953541 3120.332407 1.070456995 0.098226837 0.75814266 1 162.411566 181.3435478 7873 mesencephalic astrocyte derived neurotrophic factor "GO:0002576,GO:0003723,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005783,GO:0005788,GO:0005829,GO:0006986,GO:0007165,GO:0008083,GO:0031175,GO:0033018,GO:0048471,GO:0071542,GO:0120146,GO:1905897" platelet degranulation|RNA binding|protein binding|extracellular region|extracellular space|nucleus|endoplasmic reticulum|endoplasmic reticulum lumen|cytosol|response to unfolded protein|signal transduction|growth factor activity|neuron projection development|sarcoplasmic reticulum lumen|perinuclear region of cytoplasm|dopaminergic neuron differentiation|sulfatide binding|regulation of response to endoplasmic reticulum stress MANSC1 377.2911991 433.3861985 321.1961998 0.741131584 -0.432198387 0.327578314 1 3.967729946 3.067279532 54682 MANSC domain containing 1 "GO:0005515,GO:0016021" protein binding|integral component of membrane MANSC4 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.129546218 0.078704129 100287284 MANSC domain containing 4 GO:0016021 integral component of membrane MAOA 129.1923641 143.1087915 115.2759367 0.805512614 -0.312020914 0.622110771 1 1.359331477 1.142125029 4128 monoamine oxidase A "GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0006576,GO:0008131,GO:0009967,GO:0016021,GO:0019221,GO:0042133,GO:0042135,GO:0042420,GO:0055114" protein binding|mitochondrion|mitochondrial outer membrane|cytosol|cellular biogenic amine metabolic process|primary amine oxidase activity|positive regulation of signal transduction|integral component of membrane|cytokine-mediated signaling pathway|neurotransmitter metabolic process|neurotransmitter catabolic process|dopamine catabolic process|oxidation-reduction process "hsa00260,hsa00330,hsa00340,hsa00350,hsa00360,hsa00380,hsa00982,hsa04726,hsa04728,hsa05012,hsa05030,hsa05031,hsa05034" "Glycine, serine and threonine metabolism|Arginine and proline metabolism|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|Tryptophan metabolism|Drug metabolism - cytochrome P450|Serotonergic synapse|Dopaminergic synapse|Parkinson disease|Cocaine addiction|Amphetamine addiction|Alcoholism" MAP1A 61.34817459 85.25630134 37.44004783 0.439146987 -1.187224191 0.137492892 1 0.420604997 0.192663863 4130 microtubule associated protein 1A "GO:0000226,GO:0003779,GO:0005198,GO:0005515,GO:0005737,GO:0005829,GO:0005874,GO:0005875,GO:0007409,GO:0007613,GO:0008017,GO:0008093,GO:0008306,GO:0015631,GO:0016358,GO:0030424,GO:0030425,GO:0031114,GO:0032435,GO:0043005,GO:0043025,GO:0043194,GO:0043198,GO:0044307,GO:0045202,GO:0048156,GO:0048167,GO:0050882,GO:0070050,GO:0099641,GO:0099642,GO:0150001,GO:1901588,GO:1902817,GO:1903829,GO:1904115,GO:1990535,GO:2000010" microtubule cytoskeleton organization|actin binding|structural molecule activity|protein binding|cytoplasm|cytosol|microtubule|microtubule associated complex|axonogenesis|memory|microtubule binding|cytoskeletal anchor activity|associative learning|tubulin binding|dendrite development|axon|dendrite|regulation of microtubule depolymerization|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|neuron projection|neuronal cell body|axon initial segment|dendritic shaft|dendritic branch|synapse|tau protein binding|regulation of synaptic plasticity|voluntary musculoskeletal movement|neuron cellular homeostasis|anterograde axonal protein transport|retrograde axonal protein transport|primary dendrite|dendritic microtubule|negative regulation of protein localization to microtubule|positive regulation of cellular protein localization|axon cytoplasm|neuron projection maintenance|positive regulation of protein localization to cell surface MAP1B 11462.60807 10140.42508 12784.79107 1.260774669 0.334310454 0.3266604 1 43.11785384 56.70358797 4131 microtubule associated protein 1B "GO:0000226,GO:0001578,GO:0001750,GO:0001764,GO:0003779,GO:0005198,GO:0005515,GO:0005543,GO:0005829,GO:0005874,GO:0005875,GO:0005886,GO:0007026,GO:0007409,GO:0007416,GO:0008017,GO:0009612,GO:0009743,GO:0009987,GO:0010035,GO:0014012,GO:0014069,GO:0016358,GO:0017085,GO:0021700,GO:0030424,GO:0030425,GO:0030426,GO:0031114,GO:0031116,GO:0032355,GO:0032387,GO:0033189,GO:0036477,GO:0042493,GO:0043025,GO:0043196,GO:0043197,GO:0043204,GO:0044877,GO:0045202,GO:0045666,GO:0045773,GO:0047497,GO:0048471,GO:0048675,GO:0051915,GO:0061162,GO:0071363,GO:0071375,GO:0097440,GO:0097441,GO:0097457" microtubule cytoskeleton organization|microtubule bundle formation|photoreceptor outer segment|neuron migration|actin binding|structural molecule activity|protein binding|phospholipid binding|cytosol|microtubule|microtubule associated complex|plasma membrane|negative regulation of microtubule depolymerization|axonogenesis|synapse assembly|microtubule binding|response to mechanical stimulus|response to carbohydrate|cellular process|response to inorganic substance|peripheral nervous system axon regeneration|postsynaptic density|dendrite development|response to insecticide|developmental maturation|axon|dendrite|growth cone|regulation of microtubule depolymerization|positive regulation of microtubule polymerization|response to estradiol|negative regulation of intracellular transport|response to vitamin A|somatodendritic compartment|response to drug|neuronal cell body|varicosity|dendritic spine|perikaryon|protein-containing complex binding|synapse|positive regulation of neuron differentiation|positive regulation of axon extension|mitochondrion transport along microtubule|perinuclear region of cytoplasm|axon extension|induction of synaptic plasticity by chemical substance|establishment of monopolar cell polarity|cellular response to growth factor stimulus|cellular response to peptide hormone stimulus|apical dendrite|basal dendrite|hippocampal mossy fiber MAP1LC3A 156.0617274 161.377999 150.7454557 0.934114047 -0.098329394 0.876679522 1 6.258213124 6.097701797 84557 microtubule associated protein 1 light chain 3 alpha "GO:0000045,GO:0000421,GO:0000422,GO:0005515,GO:0005543,GO:0005770,GO:0005776,GO:0005829,GO:0005874,GO:0006995,GO:0008017,GO:0008429,GO:0009267,GO:0010040,GO:0010288,GO:0016236,GO:0031090,GO:0031625,GO:0034198,GO:0043231,GO:0043278,GO:0044754,GO:0045202,GO:0070301,GO:0071280,GO:0097352" autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|protein binding|phospholipid binding|late endosome|autophagosome|cytosol|microtubule|cellular response to nitrogen starvation|microtubule binding|phosphatidylethanolamine binding|cellular response to starvation|response to iron(II) ion|response to lead ion|macroautophagy|organelle membrane|ubiquitin protein ligase binding|cellular response to amino acid starvation|intracellular membrane-bounded organelle|response to morphine|autolysosome|synapse|cellular response to hydrogen peroxide|cellular response to copper ion|autophagosome maturation hsa04216 Ferroptosis MAP1LC3B 1200.749073 1159.079716 1242.418429 1.071900761 0.100171344 0.771328126 1 27.34201147 30.57038935 81631 microtubule associated protein 1 light chain 3 beta "GO:0000045,GO:0000421,GO:0000422,GO:0000423,GO:0005515,GO:0005739,GO:0005776,GO:0005829,GO:0005874,GO:0005930,GO:0006914,GO:0006995,GO:0008017,GO:0009267,GO:0012505,GO:0016236,GO:0031090,GO:0031410,GO:0031625,GO:0043231,GO:0097352" autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|mitophagy|protein binding|mitochondrion|autophagosome|cytosol|microtubule|axoneme|autophagy|cellular response to nitrogen starvation|microtubule binding|cellular response to starvation|endomembrane system|macroautophagy|organelle membrane|cytoplasmic vesicle|ubiquitin protein ligase binding|intracellular membrane-bounded organelle|autophagosome maturation hsa04216 Ferroptosis MAP1LC3B2 43.99000269 43.64310664 44.33689874 1.015896946 0.02275406 1 1 2.702163066 2.863367808 643246 microtubule associated protein 1 light chain 3 beta 2 "GO:0000045,GO:0000421,GO:0000422,GO:0005776,GO:0005829,GO:0005874,GO:0006995,GO:0008017,GO:0012505,GO:0016236,GO:0031410,GO:0031625,GO:0043231,GO:0097352" autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|autophagosome|cytosol|microtubule|cellular response to nitrogen starvation|microtubule binding|endomembrane system|macroautophagy|cytoplasmic vesicle|ubiquitin protein ligase binding|intracellular membrane-bounded organelle|autophagosome maturation hsa04216 Ferroptosis MAP1S 570.4866562 506.4630282 634.5102843 1.252826463 0.325186592 0.411820495 1 6.753703445 8.825693372 55201 microtubule associated protein 1S "GO:0000226,GO:0001578,GO:0003677,GO:0003779,GO:0004536,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005819,GO:0005829,GO:0005874,GO:0005875,GO:0006259,GO:0006914,GO:0006915,GO:0007399,GO:0007409,GO:0007420,GO:0008017,GO:0010848,GO:0015631,GO:0016358,GO:0030054,GO:0030425,GO:0031114,GO:0042995,GO:0043025,GO:0045202,GO:0047497,GO:0048471,GO:0048487,GO:0048812,GO:0051015" microtubule cytoskeleton organization|microtubule bundle formation|DNA binding|actin binding|deoxyribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|spindle|cytosol|microtubule|microtubule associated complex|DNA metabolic process|autophagy|apoptotic process|nervous system development|axonogenesis|brain development|microtubule binding|regulation of chromatin disassembly|tubulin binding|dendrite development|cell junction|dendrite|regulation of microtubule depolymerization|cell projection|neuronal cell body|synapse|mitochondrion transport along microtubule|perinuclear region of cytoplasm|beta-tubulin binding|neuron projection morphogenesis|actin filament binding MAP2 64.57391341 70.03196182 59.11586499 0.844126931 -0.244468142 0.769138752 1 0.309095582 0.272155104 4133 microtubule associated protein 2 "GO:0000226,GO:0001578,GO:0002162,GO:0005198,GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0005874,GO:0005875,GO:0008017,GO:0016358,GO:0021954,GO:0030425,GO:0030517,GO:0031113,GO:0031115,GO:0031175,GO:0032839,GO:0043005,GO:0043025,GO:0043194,GO:0043198,GO:0043203,GO:0044294,GO:0044304,GO:0044307,GO:0048156,GO:0048813,GO:0097441,GO:0150001,GO:0150002,GO:0150014,GO:1901953,GO:1902513,GO:1902737,GO:1903744,GO:1903827,GO:1904527,GO:1990635,GO:1990769,GO:2000575" microtubule cytoskeleton organization|microtubule bundle formation|dystroglycan binding|structural molecule activity|protein binding|calmodulin binding|cytoplasm|cytosol|microtubule|microtubule associated complex|microtubule binding|dendrite development|central nervous system neuron development|dendrite|negative regulation of axon extension|regulation of microtubule polymerization|negative regulation of microtubule polymerization|neuron projection development|dendrite cytoplasm|neuron projection|neuronal cell body|axon initial segment|dendritic shaft|axon hillock|dendritic growth cone|main axon|dendritic branch|tau protein binding|dendrite morphogenesis|basal dendrite|primary dendrite|distal dendrite|apical distal dendrite|positive regulation of anterograde dense core granule transport|regulation of organelle transport along microtubule|dendritic filopodium|positive regulation of anterograde synaptic vesicle transport|regulation of cellular protein localization|negative regulation of microtubule binding|proximal dendrite|proximal neuron projection|negative regulation of microtubule motor activity MAP2K1 1363.892481 1434.132783 1293.652179 0.902044911 -0.148728831 0.658779539 1 18.78783398 17.67749831 5604 mitogen-activated protein kinase kinase 1 "GO:0000165,GO:0000187,GO:0004672,GO:0004674,GO:0004708,GO:0004712,GO:0004713,GO:0005078,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005769,GO:0005770,GO:0005783,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0005925,GO:0006468,GO:0006935,GO:0007050,GO:0007165,GO:0007507,GO:0008022,GO:0008285,GO:0010628,GO:0010629,GO:0018107,GO:0018108,GO:0021697,GO:0030182,GO:0030216,GO:0030878,GO:0032872,GO:0043539,GO:0045893,GO:0047485,GO:0048538,GO:0048679,GO:0048870,GO:0050772,GO:0060020,GO:0060324,GO:0060440,GO:0060502,GO:0060674,GO:0060711,GO:0070371,GO:0070374,GO:0071902,GO:0090170,GO:0090398,GO:0097110,GO:1903800,GO:2000641" "MAPK cascade|activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|MAP-kinase scaffold activity|protein binding|ATP binding|nucleus|mitochondrion|early endosome|late endosome|endoplasmic reticulum|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|focal adhesion|protein phosphorylation|chemotaxis|cell cycle arrest|signal transduction|heart development|protein C-terminus binding|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|cerebellar cortex formation|neuron differentiation|keratinocyte differentiation|thyroid gland development|regulation of stress-activated MAPK cascade|protein serine/threonine kinase activator activity|positive regulation of transcription, DNA-templated|protein N-terminus binding|thymus development|regulation of axon regeneration|cell motility|positive regulation of axonogenesis|Bergmann glial cell differentiation|face development|trachea formation|epithelial cell proliferation involved in lung morphogenesis|placenta blood vessel development|labyrinthine layer development|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein serine/threonine kinase activity|regulation of Golgi inheritance|cellular senescence|scaffold protein binding|positive regulation of production of miRNAs involved in gene silencing by miRNA|regulation of early endosome to late endosome transport" "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04114,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04270,hsa04370,hsa04371,hsa04380,hsa04510,hsa04540,hsa04550,hsa04620,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04929,hsa04934,hsa04935,hsa05010,hsa05022,hsa05034,hsa05132,hsa05135,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|Toll-like receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Salmonella infection|Yersinia infection|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" MAP2K2 2868.445685 2785.039177 2951.852192 1.059896111 0.083922861 0.792790406 1 52.88804248 58.47048836 5605 mitogen-activated protein kinase kinase 2 "GO:0000165,GO:0000187,GO:0004674,GO:0004708,GO:0004712,GO:0004713,GO:0005078,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005739,GO:0005769,GO:0005770,GO:0005778,GO:0005783,GO:0005794,GO:0005829,GO:0005874,GO:0005911,GO:0005925,GO:0009898,GO:0010629,GO:0018108,GO:0030165,GO:0032872,GO:0036289,GO:0043539,GO:0045893,GO:0046872,GO:0048471,GO:0070371,GO:0071902,GO:0090170,GO:0097110,GO:1903800,GO:2000641" "MAPK cascade|activation of MAPK activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|MAP-kinase scaffold activity|protein binding|ATP binding|extracellular region|nucleus|mitochondrion|early endosome|late endosome|peroxisomal membrane|endoplasmic reticulum|Golgi apparatus|cytosol|microtubule|cell-cell junction|focal adhesion|cytoplasmic side of plasma membrane|negative regulation of gene expression|peptidyl-tyrosine phosphorylation|PDZ domain binding|regulation of stress-activated MAPK cascade|peptidyl-serine autophosphorylation|protein serine/threonine kinase activator activity|positive regulation of transcription, DNA-templated|metal ion binding|perinuclear region of cytoplasm|ERK1 and ERK2 cascade|positive regulation of protein serine/threonine kinase activity|regulation of Golgi inheritance|scaffold protein binding|positive regulation of production of miRNAs involved in gene silencing by miRNA|regulation of early endosome to late endosome transport" "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04270,hsa04370,hsa04371,hsa04540,hsa04550,hsa04620,hsa04650,hsa04660,hsa04662,hsa04664,hsa04720,hsa04722,hsa04730,hsa04810,hsa04910,hsa04912,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04929,hsa04934,hsa04935,hsa05010,hsa05022,hsa05132,hsa05135,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|VEGF signaling pathway|Apelin signaling pathway|Gap junction|Signaling pathways regulating pluripotency of stem cells|Toll-like receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Long-term potentiation|Neurotrophin signaling pathway|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Yersinia infection|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" MAP2K3 1015.728687 971.3128617 1060.144512 1.09145524 0.126252967 0.721138308 1 17.59426676 20.03055728 5606 mitogen-activated protein kinase kinase 3 "GO:0000187,GO:0001817,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006954,GO:0007165,GO:0016020,GO:0018108,GO:0019901,GO:0035331,GO:0035924,GO:0038066,GO:0043536,GO:0045860,GO:0045893,GO:0060048" "activation of MAPK activity|regulation of cytokine production|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|inflammatory response|signal transduction|membrane|peptidyl-tyrosine phosphorylation|protein kinase binding|negative regulation of hippo signaling|cellular response to vascular endothelial growth factor stimulus|p38MAPK cascade|positive regulation of blood vessel endothelial cell migration|positive regulation of protein kinase activity|positive regulation of transcription, DNA-templated|cardiac muscle contraction" "hsa04010,hsa04015,hsa04218,hsa04620,hsa04664,hsa04668,hsa04714,hsa04750,hsa04912,hsa04935,hsa05014,hsa05022,hsa05132,hsa05135,hsa05145,hsa05161,hsa05169,hsa05170,hsa05235" "MAPK signaling pathway|Rap1 signaling pathway|Cellular senescence|Toll-like receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Thermogenesis|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Yersinia infection|Toxoplasmosis|Hepatitis B|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer" MAP2K4 1016.547926 993.641893 1039.453959 1.046105208 0.065027953 0.855639433 1 11.73611393 12.80606232 6416 mitogen-activated protein kinase kinase 4 "GO:0000187,GO:0004672,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006915,GO:0007165,GO:0007254,GO:0007257,GO:0008545,GO:0009611,GO:0018108,GO:0030424,GO:0031435,GO:0032839,GO:0034393,GO:0038095,GO:0043204,GO:0043525,GO:0045740,GO:0051770,GO:0061049,GO:0071260,GO:0072709,GO:2000672" activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytosol|apoptotic process|signal transduction|JNK cascade|activation of JUN kinase activity|JUN kinase kinase activity|response to wounding|peptidyl-tyrosine phosphorylation|axon|mitogen-activated protein kinase kinase kinase binding|dendrite cytoplasm|positive regulation of smooth muscle cell apoptotic process|Fc-epsilon receptor signaling pathway|perikaryon|positive regulation of neuron apoptotic process|positive regulation of DNA replication|positive regulation of nitric-oxide synthase biosynthetic process|cell growth involved in cardiac muscle cell development|cellular response to mechanical stimulus|cellular response to sorbitol|negative regulation of motor neuron apoptotic process "hsa04010,hsa04012,hsa04620,hsa04664,hsa04668,hsa04912,hsa04926,hsa04935,hsa05120,hsa05132,hsa05135,hsa05142,hsa05161,hsa05166,hsa05167,hsa05169,hsa05418" "MAPK signaling pathway|ErbB signaling pathway|Toll-like receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|GnRH signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Epithelial cell signaling in Helicobacter pylori infection|Salmonella infection|Yersinia infection|Chagas disease|Hepatitis B|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Fluid shear stress and atherosclerosis" MAP2K5 274.7239848 190.8117221 358.6362476 1.879529432 0.910371507 0.062137665 1 0.99474427 1.95018812 5607 mitogen-activated protein kinase kinase 5 "GO:0000122,GO:0000187,GO:0004672,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005819,GO:0005829,GO:0007165,GO:0007507,GO:0018108,GO:0030307,GO:0032088,GO:0032717,GO:0034115,GO:0043154,GO:0045944,GO:0046872,GO:0050679,GO:0051247,GO:0060761,GO:0070375,GO:0071363,GO:0071499,GO:0090051,GO:2000342,GO:2001240" negative regulation of transcription by RNA polymerase II|activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|spindle|cytosol|signal transduction|heart development|peptidyl-tyrosine phosphorylation|positive regulation of cell growth|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-8 production|negative regulation of heterotypic cell-cell adhesion|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of epithelial cell proliferation|positive regulation of protein metabolic process|negative regulation of response to cytokine stimulus|ERK5 cascade|cellular response to growth factor stimulus|cellular response to laminar fluid shear stress|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04010,hsa04540,hsa04722,hsa04921,hsa05418" MAPK signaling pathway|Gap junction|Neurotrophin signaling pathway|Oxytocin signaling pathway|Fluid shear stress and atherosclerosis MAP2K6 121.3520645 179.6472064 63.05692266 0.351004193 -1.510439831 0.019244058 0.600752023 0.63679292 0.23314519 5608 mitogen-activated protein kinase kinase 6 "GO:0000165,GO:0000187,GO:0002931,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005856,GO:0006915,GO:0006975,GO:0007050,GO:0007165,GO:0018108,GO:0019901,GO:0022602,GO:0032308,GO:0042493,GO:0043065,GO:0051770,GO:0060048,GO:0070423,GO:0072709,GO:0120163" MAPK cascade|activation of MAPK activity|response to ischemia|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|cytoskeleton|apoptotic process|DNA damage induced protein phosphorylation|cell cycle arrest|signal transduction|peptidyl-tyrosine phosphorylation|protein kinase binding|ovulation cycle process|positive regulation of prostaglandin secretion|response to drug|positive regulation of apoptotic process|positive regulation of nitric-oxide synthase biosynthetic process|cardiac muscle contraction|nucleotide-binding oligomerization domain containing signaling pathway|cellular response to sorbitol|negative regulation of cold-induced thermogenesis "hsa04010,hsa04015,hsa04218,hsa04380,hsa04620,hsa04664,hsa04668,hsa04750,hsa04912,hsa04935,hsa05014,hsa05022,hsa05132,hsa05135,hsa05145,hsa05161,hsa05163,hsa05167,hsa05169,hsa05170,hsa05235,hsa05418" "MAPK signaling pathway|Rap1 signaling pathway|Cellular senescence|Osteoclast differentiation|Toll-like receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Yersinia infection|Toxoplasmosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" MAP2K7 767.9537374 736.858033 799.0494418 1.084400802 0.116898085 0.754757068 1 10.55408934 11.93786122 5609 mitogen-activated protein kinase kinase 7 "GO:0000187,GO:0000287,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0006970,GO:0007165,GO:0007254,GO:0007257,GO:0008545,GO:0009408,GO:0009411,GO:0018108,GO:0019899,GO:0019901,GO:0019903,GO:0032212,GO:0034612,GO:0038095,GO:0045893,GO:0051403,GO:0051973,GO:0070374,GO:1904355" "activation of MAPK activity|magnesium ion binding|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|apoptotic process|response to osmotic stress|signal transduction|JNK cascade|activation of JUN kinase activity|JUN kinase kinase activity|response to heat|response to UV|peptidyl-tyrosine phosphorylation|enzyme binding|protein kinase binding|protein phosphatase binding|positive regulation of telomere maintenance via telomerase|response to tumor necrosis factor|Fc-epsilon receptor signaling pathway|positive regulation of transcription, DNA-templated|stress-activated MAPK cascade|positive regulation of telomerase activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of telomere capping" "hsa04010,hsa04012,hsa04141,hsa04380,hsa04530,hsa04620,hsa04660,hsa04664,hsa04668,hsa04722,hsa04912,hsa04926,hsa05010,hsa05016,hsa05022,hsa05132,hsa05135,hsa05161,hsa05167,hsa05169,hsa05170,hsa05418" MAPK signaling pathway|ErbB signaling pathway|Protein processing in endoplasmic reticulum|Osteoclast differentiation|Tight junction|Toll-like receptor signaling pathway|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Relaxin signaling pathway|Alzheimer disease|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Yersinia infection|Hepatitis B|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Fluid shear stress and atherosclerosis MAP3K1 354.8852174 417.146903 292.6235317 0.701487964 -0.511509744 0.25496184 1 2.224833512 1.627922296 4214 mitogen-activated protein kinase kinase kinase 1 "GO:0000165,GO:0000186,GO:0002755,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0008270,GO:0019901,GO:0038095,GO:0071260" MAPK cascade|activation of MAPKK activity|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|zinc ion binding|protein kinase binding|Fc-epsilon receptor signaling pathway|cellular response to mechanical stimulus "hsa04010,hsa04120,hsa04530,hsa04622,hsa04722,hsa04912,hsa04935,hsa05161,hsa05166" "MAPK signaling pathway|Ubiquitin mediated proteolysis|Tight junction|RIG-I-like receptor signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Growth hormone synthesis, secretion and action|Hepatitis B|Human T-cell leukemia virus 1 infection" MAP3K10 438.1130906 381.6234441 494.6027371 1.296049141 0.374120421 0.377035172 1 4.828349028 6.527337292 4294 mitogen-activated protein kinase kinase kinase 10 "GO:0003714,GO:0004672,GO:0004674,GO:0004706,GO:0005524,GO:0005737,GO:0006915,GO:0007165,GO:0007224,GO:0007254,GO:0007256,GO:0007257,GO:0018105,GO:0018107,GO:0042803,GO:0043065,GO:0043425,GO:0043433,GO:0043507,GO:0045892,GO:0046330,GO:0046777" "transcription corepressor activity|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|ATP binding|cytoplasm|apoptotic process|signal transduction|smoothened signaling pathway|JNK cascade|activation of JNKK activity|activation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein homodimerization activity|positive regulation of apoptotic process|bHLH transcription factor binding|negative regulation of DNA-binding transcription factor activity|positive regulation of JUN kinase activity|negative regulation of transcription, DNA-templated|positive regulation of JNK cascade|protein autophosphorylation" "hsa05016,hsa05022" Huntington disease|Pathways of neurodegeneration - multiple diseases MAP3K11 2085.919584 1893.907837 2277.931331 1.202767783 0.26635813 0.407376714 1 27.07303151 33.96523356 4296 mitogen-activated protein kinase kinase kinase 11 "GO:0000187,GO:0004672,GO:0004674,GO:0004706,GO:0005515,GO:0005524,GO:0005737,GO:0005813,GO:0005874,GO:0006468,GO:0007017,GO:0007254,GO:0007256,GO:0007257,GO:0008219,GO:0016020,GO:0031434,GO:0031435,GO:0042802,GO:0042803,GO:0043065,GO:0043507,GO:0043525,GO:0044843,GO:0046330,GO:0046777" activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|centrosome|microtubule|protein phosphorylation|microtubule-based process|JNK cascade|activation of JNKK activity|activation of JUN kinase activity|cell death|membrane|mitogen-activated protein kinase kinase binding|mitogen-activated protein kinase kinase kinase binding|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|positive regulation of JUN kinase activity|positive regulation of neuron apoptotic process|cell cycle G1/S phase transition|positive regulation of JNK cascade|protein autophosphorylation "hsa04010,hsa04932" MAPK signaling pathway|Non-alcoholic fatty liver disease MAP3K12 926.4746665 763.2468882 1089.702445 1.427719473 0.513712537 0.150652142 1 6.152437102 9.16233138 7786 mitogen-activated protein kinase kinase kinase 12 "GO:0004672,GO:0004674,GO:0004706,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007254,GO:0007256,GO:0007257,GO:0016020,GO:0016572,GO:0018105,GO:0018107,GO:0019901,GO:0030426,GO:0035556,GO:0042803,GO:0045893,GO:0046777,GO:0070374,GO:2000672" "protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|JNK cascade|activation of JNKK activity|activation of JUN kinase activity|membrane|histone phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein kinase binding|growth cone|intracellular signal transduction|protein homodimerization activity|positive regulation of transcription, DNA-templated|protein autophosphorylation|positive regulation of ERK1 and ERK2 cascade|negative regulation of motor neuron apoptotic process" hsa04010 MAPK signaling pathway MAP3K13 160.4630041 192.841634 128.0843742 0.664194611 -0.590322077 0.309128387 1 2.347776071 1.626551991 9175 mitogen-activated protein kinase kinase kinase 13 "GO:0000186,GO:0004672,GO:0004674,GO:0004706,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0007254,GO:0007256,GO:0007257,GO:0014042,GO:0016020,GO:0018105,GO:0019899,GO:0019901,GO:0042802,GO:0042803,GO:0045773,GO:0046777,GO:0046872,GO:0051092,GO:0106137,GO:0150012,GO:1905492" activation of MAPKK activity|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|JNK cascade|activation of JNKK activity|activation of JUN kinase activity|positive regulation of neuron maturation|membrane|peptidyl-serine phosphorylation|enzyme binding|protein kinase binding|identical protein binding|protein homodimerization activity|positive regulation of axon extension|protein autophosphorylation|metal ion binding|positive regulation of NF-kappaB transcription factor activity|IkappaB kinase complex binding|positive regulation of neuron projection arborization|positive regulation of branching morphogenesis of a nerve hsa04010 MAPK signaling pathway MAP3K14 355.1727303 369.4439725 340.9014881 0.922742049 -0.116000694 0.801094048 1 4.047379166 3.895562112 9020 mitogen-activated protein kinase kinase kinase 14 "GO:0000165,GO:0000186,GO:0001650,GO:0004672,GO:0004674,GO:0004704,GO:0004709,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0006955,GO:0007249,GO:0016301,GO:0033209,GO:0038061,GO:0043123,GO:0043231,GO:0051607,GO:0071260" MAPK cascade|activation of MAPKK activity|fibrillar center|protein kinase activity|protein serine/threonine kinase activity|NF-kappaB-inducing kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|immune response|I-kappaB kinase/NF-kappaB signaling|kinase activity|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|defense response to virus|cellular response to mechanical stimulus "hsa04010,hsa04064,hsa04210,hsa04380,hsa04625,hsa04660,hsa04668,hsa04672,hsa05120,hsa05166,hsa05169" MAPK signaling pathway|NF-kappa B signaling pathway|Apoptosis|Osteoclast differentiation|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|TNF signaling pathway|Intestinal immune network for IgA production|Epithelial cell signaling in Helicobacter pylori infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection MAP3K15 45.64604863 55.82257826 35.469519 0.635397363 -0.654268993 0.45908739 1 0.396524076 0.262803351 389840 mitogen-activated protein kinase kinase kinase 15 "GO:0000165,GO:0000186,GO:0004672,GO:0004709,GO:0005524,GO:0006468,GO:0033554,GO:0046872" MAPK cascade|activation of MAPKK activity|protein kinase activity|MAP kinase kinase kinase activity|ATP binding|protein phosphorylation|cellular response to stress|metal ion binding MAP3K2 1007.699352 1129.645993 885.7527105 0.784097599 -0.350894853 0.318881935 1 4.926598156 4.029333305 10746 mitogen-activated protein kinase kinase kinase 2 "GO:0000186,GO:0000187,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0007257,GO:0019901,GO:0045893,GO:0046872,GO:0071260" "activation of MAPKK activity|activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|activation of JUN kinase activity|protein kinase binding|positive regulation of transcription, DNA-templated|metal ion binding|cellular response to mechanical stimulus" "hsa04010,hsa04540,hsa04912" MAPK signaling pathway|Gap junction|GnRH signaling pathway MAP3K20 1233.268242 1092.092622 1374.443861 1.258541477 0.331752763 0.330261218 1 9.862810027 12.94744666 51776 mitogen-activated protein kinase kinase kinase 20 "GO:0000077,GO:0000186,GO:0000287,GO:0003723,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0007010,GO:0007050,GO:0007257,GO:0008219,GO:0030154,GO:0042733,GO:0043065,GO:0051403,GO:0060173,GO:0071480,GO:1904291" DNA damage checkpoint|activation of MAPKK activity|magnesium ion binding|RNA binding|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|cytoskeleton organization|cell cycle arrest|activation of JUN kinase activity|cell death|cell differentiation|embryonic digit morphogenesis|positive regulation of apoptotic process|stress-activated MAPK cascade|limb development|cellular response to gamma radiation|positive regulation of mitotic DNA damage checkpoint hsa04010 MAPK signaling pathway MAP3K21 148.4792491 148.1835714 148.7749269 1.003990696 0.005745899 1 1 2.417061234 2.531239684 84451 mitogen-activated protein kinase kinase kinase 21 "GO:0000186,GO:0004672,GO:0004709,GO:0005515,GO:0005524,GO:0005575,GO:0005737,GO:0006468,GO:0007165,GO:0007257,GO:0042803,GO:0046777" activation of MAPKK activity|protein kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cellular_component|cytoplasm|protein phosphorylation|signal transduction|activation of JUN kinase activity|protein homodimerization activity|protein autophosphorylation MAP3K3 1344.582832 1158.06476 1531.100903 1.322120279 0.402853431 0.231204365 1 11.63497216 16.04546269 4215 mitogen-activated protein kinase kinase kinase 3 "GO:0000165,GO:0000186,GO:0001568,GO:0004672,GO:0004709,GO:0005515,GO:0005524,GO:0005829,GO:0035556,GO:0043123,GO:0046777,GO:0046872,GO:0070498,GO:0071864,GO:0090050,GO:1900745,GO:2000773" MAPK cascade|activation of MAPKK activity|blood vessel development|protein kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytosol|intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein autophosphorylation|metal ion binding|interleukin-1-mediated signaling pathway|positive regulation of cell proliferation in bone marrow|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of p38MAPK cascade|negative regulation of cellular senescence "hsa04010,hsa04722,hsa04912,hsa05166,hsa05235" MAPK signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Human T-cell leukemia virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer MAP3K4 752.2461683 774.4114039 730.0809327 0.942755916 -0.085043796 0.822099177 1 6.480701528 6.372901653 4216 mitogen-activated protein kinase kinase kinase 4 "GO:0000165,GO:0000186,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0010225,GO:0032212,GO:0035556,GO:0043507,GO:0046872,GO:0048471,GO:0051973,GO:1900745,GO:1904355" MAPK cascade|activation of MAPKK activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|response to UV-C|positive regulation of telomere maintenance via telomerase|intracellular signal transduction|positive regulation of JUN kinase activity|metal ion binding|perinuclear region of cytoplasm|positive regulation of telomerase activity|positive regulation of p38MAPK cascade|positive regulation of telomere capping "hsa04010,hsa04912" MAPK signaling pathway|GnRH signaling pathway MAP3K5 310.0759754 351.1747651 268.9771857 0.765935404 -0.384705368 0.412212781 1 2.718288702 2.171719118 4217 mitogen-activated protein kinase kinase kinase 5 "GO:0000165,GO:0000186,GO:0000287,GO:0002931,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0007254,GO:0007257,GO:0008631,GO:0009897,GO:0010666,GO:0016032,GO:0019901,GO:0019903,GO:0019904,GO:0032991,GO:0033554,GO:0034198,GO:0034976,GO:0038066,GO:0042060,GO:0042802,GO:0042803,GO:0043065,GO:0043280,GO:0043507,GO:0045087,GO:0045663,GO:0045893,GO:0046330,GO:0051403,GO:0070059,GO:0070301,GO:0071356,GO:0072577,GO:0097190,GO:0097300,GO:1900745,GO:1901216,GO:1902170,GO:1902911,GO:1904707,GO:1990604" "MAPK cascade|activation of MAPKK activity|magnesium ion binding|response to ischemia|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|cytosol|protein phosphorylation|JNK cascade|activation of JUN kinase activity|intrinsic apoptotic signaling pathway in response to oxidative stress|external side of plasma membrane|positive regulation of cardiac muscle cell apoptotic process|viral process|protein kinase binding|protein phosphatase binding|protein domain specific binding|protein-containing complex|cellular response to stress|cellular response to amino acid starvation|response to endoplasmic reticulum stress|p38MAPK cascade|wound healing|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of JUN kinase activity|innate immune response|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|stress-activated MAPK cascade|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to hydrogen peroxide|cellular response to tumor necrosis factor|endothelial cell apoptotic process|apoptotic signaling pathway|programmed necrotic cell death|positive regulation of p38MAPK cascade|positive regulation of neuron death|cellular response to reactive nitrogen species|protein kinase complex|positive regulation of vascular associated smooth muscle cell proliferation|IRE1-TRAF2-ASK1 complex" "hsa01524,hsa04010,hsa04071,hsa04141,hsa04210,hsa04530,hsa04668,hsa04714,hsa04722,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05022,hsa05418" Platinum drug resistance|MAPK signaling pathway|Sphingolipid signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Tight junction|TNF signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Fluid shear stress and atherosclerosis MAP3K6 344.3902455 238.5146526 450.2658384 1.8877911 0.916699127 0.043932362 0.952191822 2.16952689 4.272035976 9064 mitogen-activated protein kinase kinase kinase 6 "GO:0000186,GO:0000287,GO:0004672,GO:0004709,GO:0005524,GO:0006468,GO:0007165,GO:0007257,GO:0033554" activation of MAPKK activity|magnesium ion binding|protein kinase activity|MAP kinase kinase kinase activity|ATP binding|protein phosphorylation|signal transduction|activation of JUN kinase activity|cellular response to stress hsa04010 MAPK signaling pathway MAP3K7 1589.918868 1461.536594 1718.301142 1.175681231 0.233496947 0.47856075 1 14.95689483 18.34201122 6885 mitogen-activated protein kinase kinase kinase 7 "GO:0000186,GO:0000187,GO:0000287,GO:0002223,GO:0002726,GO:0002755,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005634,GO:0005671,GO:0005829,GO:0005886,GO:0007179,GO:0007223,GO:0007249,GO:0007250,GO:0007252,GO:0007254,GO:0008385,GO:0010008,GO:0016032,GO:0016239,GO:0016579,GO:0030971,GO:0032743,GO:0038095,GO:0042802,GO:0043123,GO:0043276,GO:0043507,GO:0043966,GO:0050852,GO:0051092,GO:0051403,GO:0070423,GO:0070498,GO:0097110" "activation of MAPKK activity|activation of MAPK activity|magnesium ion binding|stimulatory C-type lectin receptor signaling pathway|positive regulation of T cell cytokine production|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|cytosol|plasma membrane|transforming growth factor beta receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|I-kappaB kinase/NF-kappaB signaling|activation of NF-kappaB-inducing kinase activity|I-kappaB phosphorylation|JNK cascade|IkappaB kinase complex|endosome membrane|viral process|positive regulation of macroautophagy|protein deubiquitination|receptor tyrosine kinase binding|positive regulation of interleukin-2 production|Fc-epsilon receptor signaling pathway|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|anoikis|positive regulation of JUN kinase activity|histone H3 acetylation|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|scaffold protein binding" "hsa04010,hsa04064,hsa04140,hsa04152,hsa04310,hsa04380,hsa04520,hsa04620,hsa04621,hsa04622,hsa04657,hsa04660,hsa04668,hsa05130,hsa05131,hsa05132,hsa05135,hsa05140,hsa05145,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05171,hsa05418" MAPK signaling pathway|NF-kappa B signaling pathway|Autophagy - animal|AMPK signaling pathway|Wnt signaling pathway|Osteoclast differentiation|Adherens junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|T cell receptor signaling pathway|TNF signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Leishmaniasis|Toxoplasmosis|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Fluid shear stress and atherosclerosis MAP3K7CL 45.57181975 50.74779842 40.39584108 0.796011696 -0.329138466 0.722282654 1 0.659532195 0.547610011 56911 MAP3K7 C-terminal like "GO:0005515,GO:0005634,GO:0005829" protein binding|nucleus|cytosol MAP3K8 247.1256948 324.7859099 169.4654796 0.521775959 -0.938497621 0.063083155 1 3.688175013 2.007296448 1326 mitogen-activated protein kinase kinase kinase 8 "GO:0000186,GO:0000287,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007049,GO:0031295,GO:0051403,GO:0070498" activation of MAPKK activity|magnesium ion binding|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|cell cycle|T cell costimulation|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway "hsa04010,hsa04620,hsa04660,hsa04668" MAPK signaling pathway|Toll-like receptor signaling pathway|T cell receptor signaling pathway|TNF signaling pathway MAP3K9 1565.674486 1656.40814 1474.940832 0.890445293 -0.167401117 0.612514048 1 6.22338493 5.780292772 4293 mitogen-activated protein kinase kinase kinase 9 "GO:0004672,GO:0004674,GO:0004706,GO:0004708,GO:0005515,GO:0005524,GO:0005575,GO:0006468,GO:0006915,GO:0007256,GO:0007257,GO:0042803,GO:0043065,GO:0046777" protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein binding|ATP binding|cellular_component|protein phosphorylation|apoptotic process|activation of JNKK activity|activation of JUN kinase activity|protein homodimerization activity|positive regulation of apoptotic process|protein autophosphorylation MAP4 9619.893417 8505.331015 10734.45582 1.262085602 0.335809766 0.316945416 1 35.22775686 46.37562039 4134 microtubule associated protein 4 "GO:0000226,GO:0003723,GO:0005198,GO:0005515,GO:0005829,GO:0005874,GO:0005875,GO:0005886,GO:0005930,GO:0007052,GO:0008017,GO:0015630,GO:0030424,GO:0031175,GO:0043005,GO:0051012,GO:0051294,GO:0051301,GO:0072686,GO:1902856" microtubule cytoskeleton organization|RNA binding|structural molecule activity|protein binding|cytosol|microtubule|microtubule associated complex|plasma membrane|axoneme|mitotic spindle organization|microtubule binding|microtubule cytoskeleton|axon|neuron projection development|neuron projection|microtubule sliding|establishment of spindle orientation|cell division|mitotic spindle|negative regulation of non-motile cilium assembly MAP4K1 5.030242514 7.104691779 2.95579325 0.416033987 -1.265226703 0.543955984 1 0.12683383 0.05504018 11184 mitogen-activated protein kinase kinase kinase kinase 1 "GO:0000185,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0006468,GO:0007257,GO:0008283,GO:0008349,GO:0016020,GO:0018105,GO:0046777,GO:0106310,GO:0106311,GO:1904628" activation of MAPKKK activity|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|protein phosphorylation|activation of JUN kinase activity|cell population proliferation|MAP kinase kinase kinase kinase activity|membrane|peptidyl-serine phosphorylation|protein autophosphorylation|protein serine kinase activity|protein threonine kinase activity|cellular response to phorbol 13-acetate 12-myristate hsa04010 MAPK signaling pathway MAP4K2 955.9393189 992.6269371 919.2517006 0.926079745 -0.110791665 0.757116095 1 6.617487506 6.392304362 5871 mitogen-activated protein kinase kinase kinase kinase 2 "GO:0000139,GO:0000185,GO:0004674,GO:0005515,GO:0005524,GO:0006468,GO:0006903,GO:0006955,GO:0007254,GO:0007257,GO:0008349,GO:0016323,GO:0031435,GO:0035556,GO:0045087,GO:0046330,GO:0106310,GO:0106311" Golgi membrane|activation of MAPKKK activity|protein serine/threonine kinase activity|protein binding|ATP binding|protein phosphorylation|vesicle targeting|immune response|JNK cascade|activation of JUN kinase activity|MAP kinase kinase kinase kinase activity|basolateral plasma membrane|mitogen-activated protein kinase kinase kinase binding|intracellular signal transduction|innate immune response|positive regulation of JNK cascade|protein serine kinase activity|protein threonine kinase activity hsa04010 MAPK signaling pathway MAP4K3 540.2673448 562.2856065 518.2490831 0.921682997 -0.117657458 0.772511508 1 6.053950328 5.820179233 8491 mitogen-activated protein kinase kinase kinase kinase 3 "GO:0000185,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0006468,GO:0007254,GO:0008349,GO:0009411,GO:0034612,GO:0035556,GO:0106310,GO:0106311" activation of MAPKKK activity|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|protein phosphorylation|JNK cascade|MAP kinase kinase kinase kinase activity|response to UV|response to tumor necrosis factor|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity hsa04010 MAPK signaling pathway MAP4K4 6307.250848 6539.361304 6075.140392 0.929011276 -0.106231987 0.744260605 1 40.49835908 39.24409714 9448 mitogen-activated protein kinase kinase kinase kinase 4 "GO:0000165,GO:0001953,GO:0004111,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005925,GO:0006468,GO:0007165,GO:0008017,GO:0030033,GO:0030335,GO:0031098,GO:0032014,GO:0032147,GO:0035556,GO:0043066,GO:0043547,GO:0046328,GO:0048812,GO:0051549,GO:0051894,GO:0106310,GO:0106311,GO:0120183" MAPK cascade|negative regulation of cell-matrix adhesion|creatine kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|focal adhesion|protein phosphorylation|signal transduction|microtubule binding|microvillus assembly|positive regulation of cell migration|stress-activated protein kinase signaling cascade|positive regulation of ARF protein signal transduction|activation of protein kinase activity|intracellular signal transduction|negative regulation of apoptotic process|positive regulation of GTPase activity|regulation of JNK cascade|neuron projection morphogenesis|positive regulation of keratinocyte migration|positive regulation of focal adhesion assembly|protein serine kinase activity|protein threonine kinase activity|positive regulation of focal adhesion disassembly hsa04010 MAPK signaling pathway MAP4K5 1745.097768 1831.995523 1658.200013 0.905133223 -0.143797942 0.659940448 1 13.27383553 12.53212933 11183 mitogen-activated protein kinase kinase kinase kinase 5 "GO:0000185,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0007257,GO:0008349,GO:0035556,GO:0106310,GO:0106311" activation of MAPKKK activity|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|activation of JUN kinase activity|MAP kinase kinase kinase kinase activity|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity MAP6 144.962038 76.12169763 213.8023784 2.808691675 1.489898261 0.014379202 0.529607905 0.535086113 1.567630399 4135 microtubule associated protein 6 "GO:0000226,GO:0005515,GO:0005516,GO:0005798,GO:0005801,GO:0005874,GO:0008017,GO:0030424,GO:0030425,GO:0030658,GO:0030705,GO:0032418,GO:0048471,GO:0048813,GO:0050772,GO:0070507" microtubule cytoskeleton organization|protein binding|calmodulin binding|Golgi-associated vesicle|cis-Golgi network|microtubule|microtubule binding|axon|dendrite|transport vesicle membrane|cytoskeleton-dependent intracellular transport|lysosome localization|perinuclear region of cytoplasm|dendrite morphogenesis|positive regulation of axonogenesis|regulation of microtubule cytoskeleton organization MAP6D1 71.84190872 95.40586103 48.27795641 0.506027155 -0.982713289 0.194816495 1 2.341070877 1.235675156 79929 MAP6 domain containing 1 "GO:0000226,GO:0005516,GO:0005798,GO:0005801,GO:0005874,GO:0007026,GO:0008017,GO:0018009,GO:0030705,GO:0070507" microtubule cytoskeleton organization|calmodulin binding|Golgi-associated vesicle|cis-Golgi network|microtubule|negative regulation of microtubule depolymerization|microtubule binding|N-terminal peptidyl-L-cysteine N-palmitoylation|cytoskeleton-dependent intracellular transport|regulation of microtubule cytoskeleton organization MAP7 161.4240201 123.8246281 199.0234121 1.607300705 0.684639864 0.237141513 1 1.194984868 2.003435989 9053 microtubule associated protein 7 "GO:0000226,GO:0005102,GO:0005198,GO:0005515,GO:0005829,GO:0005874,GO:0005875,GO:0006970,GO:0007163,GO:0015630,GO:0016323,GO:0030424,GO:0048471,GO:0072659" microtubule cytoskeleton organization|signaling receptor binding|structural molecule activity|protein binding|cytosol|microtubule|microtubule associated complex|response to osmotic stress|establishment or maintenance of cell polarity|microtubule cytoskeleton|basolateral plasma membrane|axon|perinuclear region of cytoplasm|protein localization to plasma membrane MAP7D1 2671.459111 2520.135669 2822.782553 1.120091504 0.163616596 0.60798757 1 37.70634598 44.05385126 55700 MAP7 domain containing 1 "GO:0000226,GO:0005819,GO:0005829,GO:0015630" microtubule cytoskeleton organization|spindle|cytosol|microtubule cytoskeleton MAP7D3 600.5142104 605.9287131 595.0997076 0.982128252 -0.026016663 0.951472521 1 4.721254113 4.836614904 79649 MAP7 domain containing 3 "GO:0000226,GO:0005737,GO:0005819,GO:0008017,GO:0015630,GO:0015631,GO:0016020,GO:0046785" microtubule cytoskeleton organization|cytoplasm|spindle|microtubule binding|microtubule cytoskeleton|tubulin binding|membrane|microtubule polymerization MAP9 429.4090144 392.7879598 466.030069 1.186467297 0.246672336 0.563876311 1 2.575187636 3.186989118 79884 microtubule associated protein 9 "GO:0000235,GO:0000281,GO:0005737,GO:0008017,GO:0030424,GO:0046602,GO:0051233,GO:0060236,GO:0072686,GO:0090307,GO:1902412,GO:1990023" astral microtubule|mitotic cytokinesis|cytoplasm|microtubule binding|axon|regulation of mitotic centrosome separation|spindle midzone|regulation of mitotic spindle organization|mitotic spindle|mitotic spindle assembly|regulation of mitotic cytokinesis|mitotic spindle midzone MAPK1 4348.57784 4116.661408 4580.494273 1.112672095 0.154028492 0.629863693 1 34.28619924 39.79261414 5594 mitogen-activated protein kinase 1 "GO:0000165,GO:0000186,GO:0000187,GO:0001784,GO:0003690,GO:0004674,GO:0004707,GO:0004708,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005769,GO:0005770,GO:0005794,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0005925,GO:0006468,GO:0006915,GO:0006935,GO:0006974,GO:0007049,GO:0007165,GO:0007166,GO:0007268,GO:0007411,GO:0007568,GO:0007611,GO:0008134,GO:0008353,GO:0008543,GO:0009636,GO:0010468,GO:0010628,GO:0010759,GO:0010800,GO:0014066,GO:0014069,GO:0015966,GO:0016032,GO:0016301,GO:0018105,GO:0018107,GO:0019233,GO:0019858,GO:0019902,GO:0030168,GO:0030278,GO:0030424,GO:0030641,GO:0030878,GO:0031143,GO:0031435,GO:0031647,GO:0031663,GO:0032212,GO:0032839,GO:0032872,GO:0032991,GO:0033598,GO:0034198,GO:0034614,GO:0035094,GO:0035556,GO:0035578,GO:0038095,GO:0038096,GO:0038127,GO:0042307,GO:0042473,GO:0042802,GO:0043204,GO:0043312,GO:0043330,GO:0043627,GO:0045596,GO:0045727,GO:0045893,GO:0046697,GO:0048538,GO:0050852,GO:0050853,GO:0051090,GO:0051403,GO:0051493,GO:0051973,GO:0060020,GO:0060045,GO:0060291,GO:0060324,GO:0060425,GO:0060440,GO:0060716,GO:0061308,GO:0070371,GO:0070849,GO:0071276,GO:0071356,GO:0072584,GO:0072686,GO:0090170,GO:0097011,GO:0120041,GO:1900034,GO:1903351,GO:1904355,GO:1904813,GO:2000641" "MAPK cascade|activation of MAPKK activity|activation of MAPK activity|phosphotyrosine residue binding|double-stranded DNA binding|protein serine/threonine kinase activity|MAP kinase activity|MAP kinase kinase activity|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|early endosome|late endosome|Golgi apparatus|microtubule organizing center|cytosol|cytoskeleton|plasma membrane|caveola|focal adhesion|protein phosphorylation|apoptotic process|chemotaxis|cellular response to DNA damage stimulus|cell cycle|signal transduction|cell surface receptor signaling pathway|chemical synaptic transmission|axon guidance|aging|learning or memory|transcription factor binding|RNA polymerase II CTD heptapeptide repeat kinase activity|fibroblast growth factor receptor signaling pathway|response to toxic substance|regulation of gene expression|positive regulation of gene expression|positive regulation of macrophage chemotaxis|positive regulation of peptidyl-threonine phosphorylation|regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|diadenosine tetraphosphate biosynthetic process|viral process|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sensory perception of pain|cytosine metabolic process|phosphatase binding|platelet activation|regulation of ossification|axon|regulation of cellular pH|thyroid gland development|pseudopodium|mitogen-activated protein kinase kinase kinase binding|regulation of protein stability|lipopolysaccharide-mediated signaling pathway|positive regulation of telomere maintenance via telomerase|dendrite cytoplasm|regulation of stress-activated MAPK cascade|protein-containing complex|mammary gland epithelial cell proliferation|cellular response to amino acid starvation|cellular response to reactive oxygen species|response to nicotine|intracellular signal transduction|azurophil granule lumen|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB signaling pathway|positive regulation of protein import into nucleus|outer ear morphogenesis|identical protein binding|perikaryon|neutrophil degranulation|response to exogenous dsRNA|response to estrogen|negative regulation of cell differentiation|positive regulation of translation|positive regulation of transcription, DNA-templated|decidualization|thymus development|T cell receptor signaling pathway|B cell receptor signaling pathway|regulation of DNA-binding transcription factor activity|stress-activated MAPK cascade|regulation of cytoskeleton organization|positive regulation of telomerase activity|Bergmann glial cell differentiation|positive regulation of cardiac muscle cell proliferation|long-term synaptic potentiation|face development|lung morphogenesis|trachea formation|labyrinthine layer blood vessel development|cardiac neural crest cell development involved in heart development|ERK1 and ERK2 cascade|response to epidermal growth factor|cellular response to cadmium ion|cellular response to tumor necrosis factor|caveolin-mediated endocytosis|mitotic spindle|regulation of Golgi inheritance|cellular response to granulocyte macrophage colony-stimulating factor stimulus|positive regulation of macrophage proliferation|regulation of cellular response to heat|cellular response to dopamine|positive regulation of telomere capping|ficolin-1-rich granule lumen|regulation of early endosome to late endosome transport" "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04114,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04261,hsa04270,hsa04350,hsa04360,hsa04370,hsa04371,hsa04380,hsa04510,hsa04520,hsa04540,hsa04550,hsa04611,hsa04620,hsa04621,hsa04625,hsa04650,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04713,hsa04720,hsa04722,hsa04723,hsa04724,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04929,hsa04930,hsa04933,hsa04934,hsa04935,hsa04960,hsa05010,hsa05020,hsa05022,hsa05034,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|TGF-beta signaling pathway|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Adherens junction|Gap junction|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Type II diabetes mellitus|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" MAPK10 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.014170624 0.014348632 5602 mitogen-activated protein kinase 10 "GO:0000187,GO:0004705,GO:0004707,GO:0004708,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0007254,GO:0007258,GO:0009416,GO:0010468,GO:0035556,GO:0038095,GO:0042752,GO:0048511,GO:0051090" activation of MAPK activity|JUN kinase activity|MAP kinase activity|MAP kinase kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|protein phosphorylation|signal transduction|JNK cascade|JUN phosphorylation|response to light stimulus|regulation of gene expression|intracellular signal transduction|Fc-epsilon receptor signaling pathway|regulation of circadian rhythm|rhythmic process|regulation of DNA-binding transcription factor activity "hsa01522,hsa04010,hsa04012,hsa04014,hsa04024,hsa04068,hsa04071,hsa04137,hsa04140,hsa04141,hsa04210,hsa04215,hsa04217,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04722,hsa04723,hsa04728,hsa04750,hsa04910,hsa04912,hsa04914,hsa04917,hsa04920,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05142,hsa05145,hsa05152,hsa05161,hsa05162,hsa05166,hsa05167,hsa05169,hsa05170,hsa05171,hsa05200,hsa05210,hsa05212,hsa05231,hsa05418" "Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Necroptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis" MAPK11 578.7898965 467.8947014 689.6850916 1.474017743 0.55975389 0.155976724 1 9.800337466 15.06814086 5600 mitogen-activated protein kinase 11 "GO:0000187,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0007265,GO:0010468,GO:0010628,GO:0032735,GO:0035556,GO:0045648,GO:0048010,GO:0051090,GO:0051149,GO:0051403,GO:0060044,GO:0071347,GO:0098586,GO:1901796" activation of MAPK activity|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|Ras protein signal transduction|regulation of gene expression|positive regulation of gene expression|positive regulation of interleukin-12 production|intracellular signal transduction|positive regulation of erythrocyte differentiation|vascular endothelial growth factor receptor signaling pathway|regulation of DNA-binding transcription factor activity|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|negative regulation of cardiac muscle cell proliferation|cellular response to interleukin-1|cellular response to virus|regulation of signal transduction by p53 class mediator "hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04114,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa04935,hsa05014,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05163,hsa05167,hsa05169,hsa05170,hsa05171,hsa05205,hsa05235,hsa05418" "Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" MAPK12 954.1672283 938.8342707 969.5001859 1.032663822 0.046370669 0.899005112 1 26.74276929 28.80588813 6300 mitogen-activated protein kinase 12 "GO:0000165,GO:0000287,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006975,GO:0007050,GO:0007165,GO:0007517,GO:0010468,GO:0010952,GO:0018105,GO:0035556,GO:0045445,GO:0051149" MAPK cascade|magnesium ion binding|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|DNA damage induced protein phosphorylation|cell cycle arrest|signal transduction|muscle organ development|regulation of gene expression|positive regulation of peptidase activity|peptidyl-serine phosphorylation|intracellular signal transduction|myoblast differentiation|positive regulation of muscle cell differentiation "hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04114,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa04935,hsa05014,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05163,hsa05167,hsa05169,hsa05170,hsa05171,hsa05205,hsa05235,hsa05418" "Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" MAPK13 871.4159037 804.8600829 937.9717246 1.165384822 0.220806426 0.542102232 1 6.098642104 7.413417093 5603 mitogen-activated protein kinase 13 "GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006970,GO:0007049,GO:0010468,GO:0018105,GO:0032755,GO:0034644,GO:0035556,GO:0050729,GO:0051403,GO:0070301,GO:0071347,GO:0072709,GO:0072740,GO:1903936" protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|response to osmotic stress|cell cycle|regulation of gene expression|peptidyl-serine phosphorylation|positive regulation of interleukin-6 production|cellular response to UV|intracellular signal transduction|positive regulation of inflammatory response|stress-activated MAPK cascade|cellular response to hydrogen peroxide|cellular response to interleukin-1|cellular response to sorbitol|cellular response to anisomycin|cellular response to sodium arsenite "hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04114,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa04935,hsa05014,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05163,hsa05167,hsa05169,hsa05170,hsa05171,hsa05205,hsa05235,hsa05418" "Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" MAPK14 1511.597028 1563.032191 1460.161865 0.934185408 -0.098219185 0.76818273 1 12.22202662 11.90946451 1432 mitogen-activated protein kinase 14 "GO:0000077,GO:0000187,GO:0000902,GO:0000922,GO:0001502,GO:0001525,GO:0001890,GO:0002062,GO:0004674,GO:0004707,GO:0004708,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006006,GO:0006357,GO:0006915,GO:0006935,GO:0007165,GO:0007166,GO:0007178,GO:0007265,GO:0007519,GO:0010468,GO:0010628,GO:0010831,GO:0016607,GO:0018105,GO:0019395,GO:0019899,GO:0019903,GO:0030278,GO:0030316,GO:0031281,GO:0031663,GO:0032495,GO:0032735,GO:0034774,GO:0035331,GO:0035556,GO:0035924,GO:0035994,GO:0038066,GO:0042307,GO:0042770,GO:0043312,GO:0043536,GO:0045648,GO:0045663,GO:0045944,GO:0046326,GO:0048010,GO:0048273,GO:0051090,GO:0051146,GO:0051149,GO:0051525,GO:0060045,GO:0070935,GO:0071222,GO:0071223,GO:0071356,GO:0071479,GO:0090090,GO:0090336,GO:0090400,GO:0098586,GO:0098978,GO:0099179,GO:1900015,GO:1901741,GO:1901796,GO:1904813,GO:2000379" DNA damage checkpoint|activation of MAPK activity|cell morphogenesis|spindle pole|cartilage condensation|angiogenesis|placenta development|chondrocyte differentiation|protein serine/threonine kinase activity|MAP kinase activity|MAP kinase kinase activity|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|glucose metabolic process|regulation of transcription by RNA polymerase II|apoptotic process|chemotaxis|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway|Ras protein signal transduction|skeletal muscle tissue development|regulation of gene expression|positive regulation of gene expression|positive regulation of myotube differentiation|nuclear speck|peptidyl-serine phosphorylation|fatty acid oxidation|enzyme binding|protein phosphatase binding|regulation of ossification|osteoclast differentiation|positive regulation of cyclase activity|lipopolysaccharide-mediated signaling pathway|response to muramyl dipeptide|positive regulation of interleukin-12 production|secretory granule lumen|negative regulation of hippo signaling|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|response to muscle stretch|p38MAPK cascade|positive regulation of protein import into nucleus|signal transduction in response to DNA damage|neutrophil degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of erythrocyte differentiation|positive regulation of myoblast differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|vascular endothelial growth factor receptor signaling pathway|mitogen-activated protein kinase p38 binding|regulation of DNA-binding transcription factor activity|striated muscle cell differentiation|positive regulation of muscle cell differentiation|NFAT protein binding|positive regulation of cardiac muscle cell proliferation|3'-UTR-mediated mRNA stabilization|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|cellular response to tumor necrosis factor|cellular response to ionizing radiation|negative regulation of canonical Wnt signaling pathway|positive regulation of brown fat cell differentiation|stress-induced premature senescence|cellular response to virus|glutamatergic synapse|regulation of synaptic membrane adhesion|regulation of cytokine production involved in inflammatory response|positive regulation of myoblast fusion|regulation of signal transduction by p53 class mediator|ficolin-1-rich granule lumen|positive regulation of reactive oxygen species metabolic process "hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04114,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa04935,hsa05014,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05163,hsa05167,hsa05169,hsa05170,hsa05171,hsa05205,hsa05235,hsa05418" "Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" MAPK1IP1L 2306.021769 2627.721002 1984.322535 0.755149627 -0.405165563 0.205376002 1 19.5139001 15.37067782 93487 mitogen-activated protein kinase 1 interacting protein 1 like GO:0005515 protein binding MAPK3 1228.019272 1204.752734 1251.285809 1.038624585 0.054674281 0.874733325 1 33.08919517 35.84765342 5595 mitogen-activated protein kinase 3 "GO:0000165,GO:0000186,GO:0000187,GO:0001784,GO:0001934,GO:0004674,GO:0004707,GO:0004708,GO:0005515,GO:0005524,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005739,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0005925,GO:0006361,GO:0006468,GO:0006915,GO:0006975,GO:0007049,GO:0007166,GO:0007411,GO:0007568,GO:0008543,GO:0009636,GO:0010468,GO:0010628,GO:0010759,GO:0014066,GO:0016032,GO:0016310,GO:0018105,GO:0019233,GO:0019369,GO:0019902,GO:0030168,GO:0030278,GO:0030509,GO:0030641,GO:0030878,GO:0031143,GO:0031281,GO:0031663,GO:0032212,GO:0032872,GO:0032991,GO:0033129,GO:0034198,GO:0034614,GO:0035066,GO:0035556,GO:0038083,GO:0038095,GO:0038096,GO:0042473,GO:0042802,GO:0043330,GO:0045727,GO:0045944,GO:0046697,GO:0048538,GO:0051090,GO:0051216,GO:0051403,GO:0051493,GO:0051973,GO:0060020,GO:0060324,GO:0060425,GO:0060440,GO:0061308,GO:0065003,GO:0070371,GO:0070374,GO:0070498,GO:0070849,GO:0071260,GO:0071276,GO:0071356,GO:0072584,GO:0090170,GO:0097110,GO:0120041,GO:1900034,GO:1903351,GO:1904355,GO:1904417,GO:2000641,GO:2000657" MAPK cascade|activation of MAPKK activity|activation of MAPK activity|phosphotyrosine residue binding|positive regulation of protein phosphorylation|protein serine/threonine kinase activity|MAP kinase activity|MAP kinase kinase activity|protein binding|ATP binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrion|early endosome|late endosome|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|caveola|focal adhesion|transcription initiation from RNA polymerase I promoter|protein phosphorylation|apoptotic process|DNA damage induced protein phosphorylation|cell cycle|cell surface receptor signaling pathway|axon guidance|aging|fibroblast growth factor receptor signaling pathway|response to toxic substance|regulation of gene expression|positive regulation of gene expression|positive regulation of macrophage chemotaxis|regulation of phosphatidylinositol 3-kinase signaling|viral process|phosphorylation|peptidyl-serine phosphorylation|sensory perception of pain|arachidonic acid metabolic process|phosphatase binding|platelet activation|regulation of ossification|BMP signaling pathway|regulation of cellular pH|thyroid gland development|pseudopodium|positive regulation of cyclase activity|lipopolysaccharide-mediated signaling pathway|positive regulation of telomere maintenance via telomerase|regulation of stress-activated MAPK cascade|protein-containing complex|positive regulation of histone phosphorylation|cellular response to amino acid starvation|cellular response to reactive oxygen species|positive regulation of histone acetylation|intracellular signal transduction|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|outer ear morphogenesis|identical protein binding|response to exogenous dsRNA|positive regulation of translation|positive regulation of transcription by RNA polymerase II|decidualization|thymus development|regulation of DNA-binding transcription factor activity|cartilage development|stress-activated MAPK cascade|regulation of cytoskeleton organization|positive regulation of telomerase activity|Bergmann glial cell differentiation|face development|lung morphogenesis|trachea formation|cardiac neural crest cell development involved in heart development|protein-containing complex assembly|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|interleukin-1-mediated signaling pathway|response to epidermal growth factor|cellular response to mechanical stimulus|cellular response to cadmium ion|cellular response to tumor necrosis factor|caveolin-mediated endocytosis|regulation of Golgi inheritance|scaffold protein binding|positive regulation of macrophage proliferation|regulation of cellular response to heat|cellular response to dopamine|positive regulation of telomere capping|positive regulation of xenophagy|regulation of early endosome to late endosome transport|negative regulation of apolipoprotein binding "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04114,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04261,hsa04270,hsa04350,hsa04360,hsa04370,hsa04371,hsa04380,hsa04510,hsa04520,hsa04540,hsa04550,hsa04611,hsa04620,hsa04621,hsa04625,hsa04650,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04713,hsa04720,hsa04722,hsa04723,hsa04724,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04929,hsa04930,hsa04933,hsa04934,hsa04935,hsa04960,hsa05010,hsa05020,hsa05022,hsa05034,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|TGF-beta signaling pathway|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Adherens junction|Gap junction|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Type II diabetes mellitus|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" MAPK6 903.1467627 886.0565604 920.2369651 1.038575872 0.054606615 0.881937378 1 10.15975526 11.00620011 5597 mitogen-activated protein kinase 6 "GO:0000165,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0007049,GO:0007165,GO:0010468,GO:0035556" MAPK cascade|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|cell cycle|signal transduction|regulation of gene expression|intracellular signal transduction hsa04657 IL-17 signaling pathway MAPK7 851.2813257 943.9090506 758.6536007 0.803735911 -0.315206552 0.385457434 1 13.14425722 11.01958786 5598 mitogen-activated protein kinase 7 "GO:0000165,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007049,GO:0007165,GO:0007411,GO:0010468,GO:0016605,GO:0018105,GO:0019933,GO:0034115,GO:0035556,GO:0036003,GO:0045765,GO:0045944,GO:0050728,GO:0051019,GO:0051247,GO:0051344,GO:0060761,GO:0070301,GO:0070885,GO:0071363,GO:0071499,GO:0071560,GO:1902176,GO:2000352,GO:2001240" MAPK cascade|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell cycle|signal transduction|axon guidance|regulation of gene expression|PML body|peptidyl-serine phosphorylation|cAMP-mediated signaling|negative regulation of heterotypic cell-cell adhesion|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|mitogen-activated protein kinase binding|positive regulation of protein metabolic process|negative regulation of cyclic-nucleotide phosphodiesterase activity|negative regulation of response to cytokine stimulus|cellular response to hydrogen peroxide|negative regulation of calcineurin-NFAT signaling cascade|cellular response to growth factor stimulus|cellular response to laminar fluid shear stress|cellular response to transforming growth factor beta stimulus|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of endothelial cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04010,hsa04540,hsa04657,hsa04722,hsa04912,hsa04921,hsa05206,hsa05418" MAPK signaling pathway|Gap junction|IL-17 signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Oxytocin signaling pathway|MicroRNAs in cancer|Fluid shear stress and atherosclerosis MAPK8 843.9702769 713.5140458 974.426508 1.365672496 0.44961155 0.216329894 1 5.830424216 8.305440046 5599 mitogen-activated protein kinase 8 "GO:0004674,GO:0004705,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006468,GO:0006979,GO:0007254,GO:0007258,GO:0009411,GO:0009612,GO:0010468,GO:0010628,GO:0016241,GO:0016301,GO:0018105,GO:0018107,GO:0019899,GO:0030424,GO:0031063,GO:0031281,GO:0032091,GO:0032880,GO:0034198,GO:0034614,GO:0035033,GO:0035556,GO:0038095,GO:0042752,GO:0042826,GO:0043065,GO:0043066,GO:0045202,GO:0048511,GO:0051090,GO:0051247,GO:0051403,GO:0071222,GO:0071260,GO:0071276,GO:0071345,GO:0090045,GO:0097441,GO:1900740,GO:1902595" protein serine/threonine kinase activity|JUN kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|protein phosphorylation|response to oxidative stress|JNK cascade|JUN phosphorylation|response to UV|response to mechanical stimulus|regulation of gene expression|positive regulation of gene expression|regulation of macroautophagy|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|enzyme binding|axon|regulation of histone deacetylation|positive regulation of cyclase activity|negative regulation of protein binding|regulation of protein localization|cellular response to amino acid starvation|cellular response to reactive oxygen species|histone deacetylase regulator activity|intracellular signal transduction|Fc-epsilon receptor signaling pathway|regulation of circadian rhythm|histone deacetylase binding|positive regulation of apoptotic process|negative regulation of apoptotic process|synapse|rhythmic process|regulation of DNA-binding transcription factor activity|positive regulation of protein metabolic process|stress-activated MAPK cascade|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to cadmium ion|cellular response to cytokine stimulus|positive regulation of deacetylase activity|basal dendrite|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of DNA replication origin binding "hsa01522,hsa04010,hsa04012,hsa04014,hsa04024,hsa04068,hsa04071,hsa04137,hsa04140,hsa04141,hsa04210,hsa04215,hsa04217,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04722,hsa04723,hsa04728,hsa04750,hsa04910,hsa04912,hsa04914,hsa04917,hsa04920,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05142,hsa05145,hsa05152,hsa05161,hsa05162,hsa05166,hsa05167,hsa05169,hsa05170,hsa05171,hsa05200,hsa05210,hsa05212,hsa05231,hsa05418" "Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Necroptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis" MAPK8IP1 566.4834939 535.8967513 597.0702364 1.114151625 0.155945583 0.696596385 1 8.898780303 10.34167089 9479 mitogen-activated protein kinase 8 interacting protein 1 "GO:0004860,GO:0005078,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0006355,GO:0007258,GO:0008432,GO:0016192,GO:0019894,GO:0031434,GO:0031435,GO:0031966,GO:0043508,GO:0044294,GO:0044295,GO:0044297,GO:0044302,GO:0045202,GO:0046328,GO:0046330,GO:0048471,GO:2000564,GO:2001243" "protein kinase inhibitor activity|MAP-kinase scaffold activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|regulation of transcription, DNA-templated|JUN phosphorylation|JUN kinase binding|vesicle-mediated transport|kinesin binding|mitogen-activated protein kinase kinase binding|mitogen-activated protein kinase kinase kinase binding|mitochondrial membrane|negative regulation of JUN kinase activity|dendritic growth cone|axonal growth cone|cell body|dentate gyrus mossy fiber|synapse|regulation of JNK cascade|positive regulation of JNK cascade|perinuclear region of cytoplasm|regulation of CD8-positive, alpha-beta T cell proliferation|negative regulation of intrinsic apoptotic signaling pathway" hsa04010 MAPK signaling pathway MAPK8IP2 181.9930851 149.1985274 214.7876428 1.439609671 0.525677699 0.34549582 1 1.324983179 1.989624178 23542 mitogen-activated protein kinase 8 interacting protein 2 "GO:0001540,GO:0001662,GO:0005078,GO:0005198,GO:0005515,GO:0005737,GO:0007172,GO:0007254,GO:0007617,GO:0010469,GO:0014069,GO:0019894,GO:0019901,GO:0032874,GO:0032991,GO:0035176,GO:0043025,GO:0044877,GO:0046328,GO:0046958,GO:0048813,GO:0051966,GO:0060079,GO:2000310,GO:2000311,GO:2001234" "amyloid-beta binding|behavioral fear response|MAP-kinase scaffold activity|structural molecule activity|protein binding|cytoplasm|signal complex assembly|JNK cascade|mating behavior|regulation of signaling receptor activity|postsynaptic density|kinesin binding|protein kinase binding|positive regulation of stress-activated MAPK cascade|protein-containing complex|social behavior|neuronal cell body|protein-containing complex binding|regulation of JNK cascade|nonassociative learning|dendrite morphogenesis|regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|regulation of NMDA receptor activity|regulation of AMPA receptor activity|negative regulation of apoptotic signaling pathway" hsa04010 MAPK signaling pathway MAPK8IP3 951.1399278 900.2659439 1002.013912 1.113019901 0.154479388 0.665431568 1 6.170698892 7.163961022 23162 mitogen-activated protein kinase 8 interacting protein 3 "GO:0000139,GO:0005078,GO:0005515,GO:0005737,GO:0007257,GO:0008432,GO:0016192,GO:0019894,GO:0030159,GO:0030424,GO:0030425,GO:0030426,GO:0031103,GO:0031410,GO:0044297,GO:0046328,GO:0048471,GO:0061564,GO:0099641,GO:1904115" Golgi membrane|MAP-kinase scaffold activity|protein binding|cytoplasm|activation of JUN kinase activity|JUN kinase binding|vesicle-mediated transport|kinesin binding|signaling receptor complex adaptor activity|axon|dendrite|growth cone|axon regeneration|cytoplasmic vesicle|cell body|regulation of JNK cascade|perinuclear region of cytoplasm|axon development|anterograde axonal protein transport|axon cytoplasm hsa04010 MAPK signaling pathway MAPK9 1489.996924 1366.130733 1613.863114 1.181338707 0.240422666 0.469082569 1 10.14214339 12.49741266 5601 mitogen-activated protein kinase 9 "GO:0004705,GO:0004707,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006468,GO:0007254,GO:0007258,GO:0008134,GO:0010468,GO:0010628,GO:0010744,GO:0018105,GO:0031398,GO:0034614,GO:0035556,GO:0038095,GO:0042752,GO:0048511,GO:0051090,GO:0061833,GO:0071276,GO:0071803,GO:1901485,GO:2001235" JUN kinase activity|MAP kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|protein phosphorylation|JNK cascade|JUN phosphorylation|transcription factor binding|regulation of gene expression|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|peptidyl-serine phosphorylation|positive regulation of protein ubiquitination|cellular response to reactive oxygen species|intracellular signal transduction|Fc-epsilon receptor signaling pathway|regulation of circadian rhythm|rhythmic process|regulation of DNA-binding transcription factor activity|protein localization to tricellular tight junction|cellular response to cadmium ion|positive regulation of podosome assembly|positive regulation of transcription factor catabolic process|positive regulation of apoptotic signaling pathway "hsa01522,hsa04010,hsa04012,hsa04014,hsa04024,hsa04068,hsa04071,hsa04137,hsa04140,hsa04141,hsa04210,hsa04215,hsa04217,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04722,hsa04723,hsa04728,hsa04750,hsa04910,hsa04912,hsa04914,hsa04917,hsa04920,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05142,hsa05145,hsa05152,hsa05161,hsa05162,hsa05166,hsa05167,hsa05169,hsa05170,hsa05171,hsa05200,hsa05210,hsa05212,hsa05231,hsa05418" "Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Necroptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis" MAPKAP1 1917.634839 2244.067646 1591.202033 0.70907044 -0.495999141 0.125295624 1 30.99375775 22.92342702 79109 MAPK associated protein 1 "GO:0005515,GO:0005546,GO:0005547,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0019901,GO:0021762,GO:0030950,GO:0031267,GO:0031410,GO:0031932,GO:0032148,GO:0033138,GO:0038203,GO:0043325,GO:0046580,GO:0070300,GO:0080025,GO:1900407" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|protein kinase binding|substantia nigra development|establishment or maintenance of actin cytoskeleton polarity|small GTPase binding|cytoplasmic vesicle|TORC2 complex|activation of protein kinase B activity|positive regulation of peptidyl-serine phosphorylation|TORC2 signaling|phosphatidylinositol-3,4-bisphosphate binding|negative regulation of Ras protein signal transduction|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|regulation of cellular response to oxidative stress" hsa04150 mTOR signaling pathway MAPKAPK2 2360.697509 2155.766477 2565.628541 1.190123591 0.251111401 0.432118812 1 33.13565006 41.13424106 9261 MAPK activated protein kinase 2 "GO:0000165,GO:0000187,GO:0002224,GO:0004672,GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0006691,GO:0006954,GO:0006974,GO:0009931,GO:0018105,GO:0032496,GO:0032675,GO:0032680,GO:0032760,GO:0034097,GO:0035556,GO:0035924,GO:0038066,GO:0043488,GO:0044351,GO:0046777,GO:0048010,GO:0048839,GO:0051019,GO:0070062,GO:0070935,GO:0106310,GO:0106311,GO:1900034" MAPK cascade|activation of MAPK activity|toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|leukotriene metabolic process|inflammatory response|cellular response to DNA damage stimulus|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|response to lipopolysaccharide|regulation of interleukin-6 production|regulation of tumor necrosis factor production|positive regulation of tumor necrosis factor production|response to cytokine|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|p38MAPK cascade|regulation of mRNA stability|macropinocytosis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|inner ear development|mitogen-activated protein kinase binding|extracellular exosome|3'-UTR-mediated mRNA stabilization|protein serine kinase activity|protein threonine kinase activity|regulation of cellular response to heat "hsa04010,hsa04218,hsa04370,hsa04625,hsa04722,hsa05167,hsa05203" MAPK signaling pathway|Cellular senescence|VEGF signaling pathway|C-type lectin receptor signaling pathway|Neurotrophin signaling pathway|Kaposi sarcoma-associated herpesvirus infection|Viral carcinogenesis MAPKAPK3 888.904966 889.1014283 888.7085037 0.999558066 -0.000637718 1 1 14.53982912 15.15944355 7867 MAPK activated protein kinase 3 "GO:0000165,GO:0000187,GO:0002224,GO:0004674,GO:0004683,GO:0004708,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0009931,GO:0018105,GO:0032496,GO:0034097,GO:0035556,GO:0044351,GO:0046777,GO:0048010,GO:0051019,GO:0106310,GO:0106311" MAPK cascade|activation of MAPK activity|toll-like receptor signaling pathway|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|MAP kinase kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|response to lipopolysaccharide|response to cytokine|intracellular signal transduction|macropinocytosis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|mitogen-activated protein kinase binding|protein serine kinase activity|protein threonine kinase activity "hsa04010,hsa04370" MAPK signaling pathway|VEGF signaling pathway MAPKAPK5 838.1923023 722.6486495 953.7359552 1.31977823 0.400295525 0.271649448 1 3.302319295 4.546068255 8550 MAPK activated protein kinase 5 "GO:0000165,GO:0000187,GO:0002039,GO:0004674,GO:0004683,GO:0004708,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006417,GO:0007165,GO:0007265,GO:0009931,GO:0018105,GO:0032007,GO:0032212,GO:0035556,GO:0046777,GO:0051019,GO:0051973,GO:0090400,GO:0106310,GO:0106311,GO:1901796,GO:1904355" MAPK cascade|activation of MAPK activity|p53 binding|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|MAP kinase kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of translation|signal transduction|Ras protein signal transduction|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|negative regulation of TOR signaling|positive regulation of telomere maintenance via telomerase|intracellular signal transduction|protein autophosphorylation|mitogen-activated protein kinase binding|positive regulation of telomerase activity|stress-induced premature senescence|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|positive regulation of telomere capping hsa04010 MAPK signaling pathway MAPKBP1 789.4095896 688.1401466 890.6790326 1.294327961 0.372203218 0.312526171 1 4.990244961 6.737241694 23005 mitogen-activated protein kinase binding protein 1 "GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0032717,GO:0043124,GO:0097431,GO:1900425" protein binding|nucleoplasm|nucleolus|cytoplasm|negative regulation of interleukin-8 production|negative regulation of I-kappaB kinase/NF-kappaB signaling|mitotic spindle pole|negative regulation of defense response to bacterium MAPRE1 5336.018404 5444.223814 5227.812994 0.960249463 -0.058518843 0.856306585 1 102.1224926 102.287228 22919 microtubule associated protein RP/EB family member 1 "GO:0000086,GO:0001578,GO:0003723,GO:0005515,GO:0005794,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005874,GO:0005881,GO:0005925,GO:0008022,GO:0008104,GO:0010389,GO:0016477,GO:0019901,GO:0030335,GO:0030981,GO:0031110,GO:0031115,GO:0031116,GO:0031253,GO:0035371,GO:0035372,GO:0036064,GO:0042802,GO:0045296,GO:0046785,GO:0051010,GO:0051225,GO:0051233,GO:0051301,GO:0071539,GO:0097711,GO:1903033,GO:1904825,GO:1905515,GO:1905721" G2/M transition of mitotic cell cycle|microtubule bundle formation|RNA binding|protein binding|Golgi apparatus|centrosome|microtubule organizing center|spindle|cytosol|microtubule|cytoplasmic microtubule|focal adhesion|protein C-terminus binding|protein localization|regulation of G2/M transition of mitotic cell cycle|cell migration|protein kinase binding|positive regulation of cell migration|cortical microtubule cytoskeleton|regulation of microtubule polymerization or depolymerization|negative regulation of microtubule polymerization|positive regulation of microtubule polymerization|cell projection membrane|microtubule plus-end|protein localization to microtubule|ciliary basal body|identical protein binding|cadherin binding|microtubule polymerization|microtubule plus-end binding|spindle assembly|spindle midzone|cell division|protein localization to centrosome|ciliary basal body-plasma membrane docking|positive regulation of microtubule plus-end binding|protein localization to microtubule plus-end|non-motile cilium assembly|mitotic spindle astral microtubule end MAPRE2 739.8346074 666.8260712 812.8431437 1.218973251 0.285666468 0.444799821 1 7.503307729 9.540318276 10982 microtubule associated protein RP/EB family member 2 "GO:0005515,GO:0005737,GO:0005815,GO:0005881,GO:0005925,GO:0008017,GO:0015630,GO:0019901,GO:0031110,GO:0032014,GO:0035371,GO:0042802,GO:0043547,GO:0051010,GO:0051225,GO:0051233,GO:0051301,GO:0051549,GO:0120183,GO:1904825" protein binding|cytoplasm|microtubule organizing center|cytoplasmic microtubule|focal adhesion|microtubule binding|microtubule cytoskeleton|protein kinase binding|regulation of microtubule polymerization or depolymerization|positive regulation of ARF protein signal transduction|microtubule plus-end|identical protein binding|positive regulation of GTPase activity|microtubule plus-end binding|spindle assembly|spindle midzone|cell division|positive regulation of keratinocyte migration|positive regulation of focal adhesion disassembly|protein localization to microtubule plus-end MAPRE3 224.8939029 185.7369422 264.0508636 1.421638908 0.507555071 0.328855263 1 4.243085648 6.291975586 22924 microtubule associated protein RP/EB family member 3 "GO:0005515,GO:0005737,GO:0005815,GO:0008017,GO:0008022,GO:0008104,GO:0019901,GO:0030496,GO:0031110,GO:0031113,GO:0035371,GO:0042802,GO:0045737,GO:0045860,GO:0045893,GO:0051010,GO:0051225,GO:0051233,GO:0051301,GO:1903033,GO:1904825,GO:1905721" "protein binding|cytoplasm|microtubule organizing center|microtubule binding|protein C-terminus binding|protein localization|protein kinase binding|midbody|regulation of microtubule polymerization or depolymerization|regulation of microtubule polymerization|microtubule plus-end|identical protein binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of protein kinase activity|positive regulation of transcription, DNA-templated|microtubule plus-end binding|spindle assembly|spindle midzone|cell division|positive regulation of microtubule plus-end binding|protein localization to microtubule plus-end|mitotic spindle astral microtubule end" MAPT 788.7630564 744.9776808 832.548432 1.117548154 0.160336997 0.665223038 1 5.295507566 6.172907485 4137 microtubule associated protein tau "GO:0000226,GO:0001774,GO:0003677,GO:0003680,GO:0003690,GO:0003697,GO:0003723,GO:0003779,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0005886,GO:0006475,GO:0006919,GO:0007267,GO:0007613,GO:0008017,GO:0010288,GO:0010506,GO:0010629,GO:0010917,GO:0015630,GO:0016020,GO:0016072,GO:0016607,GO:0017124,GO:0019896,GO:0019899,GO:0019901,GO:0021954,GO:0030424,GO:0030425,GO:0030426,GO:0030673,GO:0030674,GO:0031110,GO:0031113,GO:0031116,GO:0031122,GO:0031175,GO:0032930,GO:0033044,GO:0033673,GO:0034063,GO:0034185,GO:0034399,GO:0034452,GO:0034605,GO:0034614,GO:0035091,GO:0036464,GO:0036477,GO:0042802,GO:0043005,GO:0043025,GO:0043197,GO:0043565,GO:0044297,GO:0044304,GO:0045121,GO:0045298,GO:0045773,GO:0046785,GO:0048143,GO:0048167,GO:0048312,GO:0048699,GO:0050808,GO:0050848,GO:0051087,GO:0051258,GO:0051721,GO:0051879,GO:0061564,GO:0070507,GO:0071813,GO:0072386,GO:0090140,GO:0090258,GO:0097386,GO:0097418,GO:0097435,GO:0098930,GO:0099077,GO:0099609,GO:1900034,GO:1900452,GO:1901216,GO:1902474,GO:1902936,GO:1902988,GO:1903748,GO:1903829,GO:1904115,GO:1904428,GO:1905689,GO:1990000,GO:1990090,GO:1990416,GO:2001020" microtubule cytoskeleton organization|microglial cell activation|DNA binding|minor groove of adenine-thymine-rich DNA binding|double-stranded DNA binding|single-stranded DNA binding|RNA binding|actin binding|protein binding|extracellular region|nucleus|cytoplasm|mitochondrion|cytosol|microtubule|plasma membrane|internal protein amino acid acetylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell-cell signaling|memory|microtubule binding|response to lead ion|regulation of autophagy|negative regulation of gene expression|negative regulation of mitochondrial membrane potential|microtubule cytoskeleton|membrane|rRNA metabolic process|nuclear speck|SH3 domain binding|axonal transport of mitochondrion|enzyme binding|protein kinase binding|central nervous system neuron development|axon|dendrite|growth cone|axolemma|protein-macromolecule adaptor activity|regulation of microtubule polymerization or depolymerization|regulation of microtubule polymerization|positive regulation of microtubule polymerization|cytoplasmic microtubule organization|neuron projection development|positive regulation of superoxide anion generation|regulation of chromosome organization|negative regulation of kinase activity|stress granule assembly|apolipoprotein binding|nuclear periphery|dynactin binding|cellular response to heat|cellular response to reactive oxygen species|phosphatidylinositol binding|cytoplasmic ribonucleoprotein granule|somatodendritic compartment|identical protein binding|neuron projection|neuronal cell body|dendritic spine|sequence-specific DNA binding|cell body|main axon|membrane raft|tubulin complex|positive regulation of axon extension|microtubule polymerization|astrocyte activation|regulation of synaptic plasticity|intracellular distribution of mitochondria|generation of neurons|synapse organization|regulation of calcium-mediated signaling|chaperone binding|protein polymerization|protein phosphatase 2A binding|Hsp90 protein binding|axon development|regulation of microtubule cytoskeleton organization|lipoprotein particle binding|plus-end-directed organelle transport along microtubule|regulation of mitochondrial fission|negative regulation of mitochondrial fission|glial cell projection|neurofibrillary tangle|supramolecular fiber organization|axonal transport|histone-dependent DNA binding|microtubule lateral binding|regulation of cellular response to heat|regulation of long-term synaptic depression|positive regulation of neuron death|positive regulation of protein localization to synapse|phosphatidylinositol bisphosphate binding|neurofibrillary tangle assembly|negative regulation of establishment of protein localization to mitochondrion|positive regulation of cellular protein localization|axon cytoplasm|negative regulation of tubulin deacetylation|positive regulation of diacylglycerol kinase activity|amyloid fibril formation|cellular response to nerve growth factor stimulus|cellular response to brain-derived neurotrophic factor stimulus|regulation of response to DNA damage stimulus "hsa04010,hsa05010,hsa05012,hsa05022" MAPK signaling pathway|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases MARCHF10 6.463601811 4.059823873 8.867379749 2.184178434 1.12709072 0.538620937 1 0.048585954 0.110691629 162333 membrane associated ring-CH-type finger 10 "GO:0005515,GO:0008270,GO:0016567,GO:0016740" protein binding|zinc ion binding|protein ubiquitination|transferase activity MARCHF2 304.4343345 335.9504255 272.9182434 0.812376537 -0.299779522 0.526424269 1 9.267267915 7.85280874 51257 membrane associated ring-CH-type finger 2 "GO:0004842,GO:0005515,GO:0005765,GO:0005783,GO:0005789,GO:0005829,GO:0006897,GO:0008270,GO:0010008,GO:0016021,GO:0016567,GO:0031410,GO:0061630" ubiquitin-protein transferase activity|protein binding|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|endocytosis|zinc ion binding|endosome membrane|integral component of membrane|protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase activity MARCHF3 62.48461836 61.91231407 63.05692266 1.018487576 0.026428381 0.996533549 1 0.351214191 0.373115869 115123 membrane associated ring-CH-type finger 3 "GO:0004842,GO:0005515,GO:0005764,GO:0005768,GO:0006897,GO:0008270,GO:0016021,GO:0016567,GO:0030659,GO:0031901,GO:0043231" ubiquitin-protein transferase activity|protein binding|lysosome|endosome|endocytosis|zinc ion binding|integral component of membrane|protein ubiquitination|cytoplasmic vesicle membrane|early endosome membrane|intracellular membrane-bounded organelle MARCHF4 411.3449262 403.9524754 418.737377 1.036600597 0.051860129 0.909678668 1 4.172704022 4.511749353 57574 membrane associated ring-CH-type finger 4 "GO:0000139,GO:0004842,GO:0005795,GO:0005802,GO:0008270,GO:0016021,GO:0016567" Golgi membrane|ubiquitin-protein transferase activity|Golgi stack|trans-Golgi network|zinc ion binding|integral component of membrane|protein ubiquitination MARCHF5 1626.237318 1485.895538 1766.579099 1.188898583 0.249625653 0.447468524 1 18.4404232 22.86818109 54708 membrane associated ring-CH-type finger 5 "GO:0000209,GO:0005515,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0008270,GO:0016020,GO:0016021,GO:0051020,GO:0051865,GO:0061630,GO:0070585,GO:0090140,GO:0090141,GO:0090344" protein polyubiquitination|protein binding|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|membrane|integral component of membrane|GTPase binding|protein autoubiquitination|ubiquitin protein ligase activity|protein localization to mitochondrion|regulation of mitochondrial fission|positive regulation of mitochondrial fission|negative regulation of cell aging MARCHF6 4822.543964 4187.708326 5457.379603 1.303189998 0.382047436 0.233695307 1 23.17699195 31.50509095 10299 membrane associated ring-CH-type finger 6 "GO:0000835,GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0008270,GO:0010498,GO:0016020,GO:0016021,GO:0016567,GO:0019899,GO:0030176,GO:0030433,GO:0031624,GO:0036503,GO:0043161,GO:0044322,GO:0061630,GO:0070936,GO:1904380,GO:1990381" ER ubiquitin ligase complex|ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|proteasomal protein catabolic process|membrane|integral component of membrane|protein ubiquitination|enzyme binding|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|ubiquitin conjugating enzyme binding|ERAD pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|endoplasmic reticulum quality control compartment|ubiquitin protein ligase activity|protein K48-linked ubiquitination|endoplasmic reticulum mannose trimming|ubiquitin-specific protease binding hsa04141 Protein processing in endoplasmic reticulum MARCHF7 1254.656546 1139.795552 1369.517539 1.20154666 0.264892674 0.435951203 1 8.934626803 11.19780724 64844 membrane associated ring-CH-type finger 7 "GO:0002643,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006513,GO:0008270,GO:0008284,GO:0016740,GO:0031624,GO:0042130,GO:0043130,GO:0043518,GO:0050821,GO:0051865,GO:0097371,GO:1901799,GO:1902166,GO:1902916,GO:1905524" "regulation of tolerance induction|protein binding|nucleus|cytosol|plasma membrane|protein monoubiquitination|zinc ion binding|positive regulation of cell population proliferation|transferase activity|ubiquitin conjugating enzyme binding|negative regulation of T cell proliferation|ubiquitin binding|negative regulation of DNA damage response, signal transduction by p53 class mediator|protein stabilization|protein autoubiquitination|MDM2/MDM4 family protein binding|negative regulation of proteasomal protein catabolic process|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of protein polyubiquitination|negative regulation of protein autoubiquitination" MARCHF8 904.6597941 821.0993784 988.2202098 1.203533014 0.267275717 0.45688658 1 6.407671318 8.044038937 220972 membrane associated ring-CH-type finger 8 "GO:0000209,GO:0002250,GO:0002495,GO:0004842,GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005768,GO:0006955,GO:0008270,GO:0016021,GO:0030659,GO:0031901,GO:0031902,GO:0042287,GO:0061630" protein polyubiquitination|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class II|ubiquitin-protein transferase activity|protein binding|cytoplasm|lysosome|lysosomal membrane|endosome|immune response|zinc ion binding|integral component of membrane|cytoplasmic vesicle membrane|early endosome membrane|late endosome membrane|MHC protein binding|ubiquitin protein ligase activity MARCHF9 727.0828315 704.3794421 749.786221 1.064463521 0.09012651 0.812853843 1 11.96723711 13.28741834 92979 membrane associated ring-CH-type finger 9 "GO:0000139,GO:0005765,GO:0005795,GO:0005802,GO:0008270,GO:0016021,GO:0016567,GO:0016740" Golgi membrane|lysosomal membrane|Golgi stack|trans-Golgi network|zinc ion binding|integral component of membrane|protein ubiquitination|transferase activity MARCKS 2046.565423 2301.920136 1791.210709 0.778137643 -0.361902722 0.260813739 1 27.13783385 22.0266035 4082 myristoylated alanine rich protein kinase C substrate "GO:0005080,GO:0005516,GO:0005737,GO:0005813,GO:0005886,GO:0005925,GO:0005938,GO:0007015,GO:0007417,GO:0015629,GO:0032432,GO:0042585,GO:0042802,GO:0051015,GO:0051017,GO:0051764,GO:0070062" protein kinase C binding|calmodulin binding|cytoplasm|centrosome|plasma membrane|focal adhesion|cell cortex|actin filament organization|central nervous system development|actin cytoskeleton|actin filament bundle|germinal vesicle|identical protein binding|actin filament binding|actin filament bundle assembly|actin crosslink formation|extracellular exosome "hsa04666,hsa05206" Fc gamma R-mediated phagocytosis|MicroRNAs in cancer MARCKSL1 2235.482575 2116.183194 2354.781956 1.112749578 0.154128953 0.630809455 1 69.32549375 80.46487468 65108 MARCKS like 1 "GO:0005515,GO:0005516,GO:0005737,GO:0005856,GO:0005886,GO:0007015,GO:0007417,GO:0008284,GO:0051015,GO:0070062" protein binding|calmodulin binding|cytoplasm|cytoskeleton|plasma membrane|actin filament organization|central nervous system development|positive regulation of cell population proliferation|actin filament binding|extracellular exosome "hsa04666,hsa05140" Fc gamma R-mediated phagocytosis|Leishmaniasis MARF1 1023.833489 986.5372013 1061.129777 1.075610504 0.10515575 0.766422678 1 6.432109803 7.216463416 9665 meiosis regulator and mRNA stability factor 1 "GO:0003674,GO:0005515,GO:0005737,GO:0005777,GO:0005794,GO:0006302,GO:0007143,GO:0010468,GO:0010923,GO:0016020,GO:0016441,GO:0043231,GO:0048477,GO:1903231,GO:1905762" molecular_function|protein binding|cytoplasm|peroxisome|Golgi apparatus|double-strand break repair|female meiotic nuclear division|regulation of gene expression|negative regulation of phosphatase activity|membrane|posttranscriptional gene silencing|intracellular membrane-bounded organelle|oogenesis|mRNA binding involved in posttranscriptional gene silencing|CCR4-NOT complex binding MARK1 338.8201118 261.8586398 415.7815838 1.587809301 0.667037652 0.143427713 1 2.040027123 3.37870452 4139 microtubule affinity regulating kinase 1 "GO:0000226,GO:0000287,GO:0001764,GO:0001786,GO:0004674,GO:0005515,GO:0005524,GO:0005546,GO:0005737,GO:0005856,GO:0005886,GO:0006468,GO:0007010,GO:0010975,GO:0015630,GO:0016055,GO:0018105,GO:0030425,GO:0035556,GO:0048156,GO:0050321,GO:0050773,GO:0051654,GO:0070300,GO:0106310,GO:0106311" "microtubule cytoskeleton organization|magnesium ion binding|neuron migration|phosphatidylserine binding|protein serine/threonine kinase activity|protein binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytoskeleton|plasma membrane|protein phosphorylation|cytoskeleton organization|regulation of neuron projection development|microtubule cytoskeleton|Wnt signaling pathway|peptidyl-serine phosphorylation|dendrite|intracellular signal transduction|tau protein binding|tau-protein kinase activity|regulation of dendrite development|establishment of mitochondrion localization|phosphatidic acid binding|protein serine kinase activity|protein threonine kinase activity" MARK2 1136.243945 1161.109628 1111.378262 0.957169104 -0.063154266 0.85698311 1 11.25260362 11.2346002 2011 microtubule affinity regulating kinase 2 "GO:0000226,GO:0000287,GO:0000422,GO:0001764,GO:0003723,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005884,GO:0005886,GO:0006468,GO:0008289,GO:0010976,GO:0016020,GO:0016055,GO:0016328,GO:0018105,GO:0018107,GO:0030010,GO:0030295,GO:0030425,GO:0032147,GO:0035556,GO:0045197,GO:0045296,GO:0046777,GO:0048156,GO:0050321,GO:0050770,GO:0051493,GO:0051646,GO:0061564,GO:0070507,GO:0071963,GO:0097427,GO:0106310,GO:0106311,GO:1904526" microtubule cytoskeleton organization|magnesium ion binding|autophagy of mitochondrion|neuron migration|RNA binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|actin filament|plasma membrane|protein phosphorylation|lipid binding|positive regulation of neuron projection development|membrane|Wnt signaling pathway|lateral plasma membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|establishment of cell polarity|protein kinase activator activity|dendrite|activation of protein kinase activity|intracellular signal transduction|establishment or maintenance of epithelial cell apical/basal polarity|cadherin binding|protein autophosphorylation|tau protein binding|tau-protein kinase activity|regulation of axonogenesis|regulation of cytoskeleton organization|mitochondrion localization|axon development|regulation of microtubule cytoskeleton organization|establishment or maintenance of cell polarity regulating cell shape|microtubule bundle|protein serine kinase activity|protein threonine kinase activity|regulation of microtubule binding MARK3 1939.394534 1946.685547 1932.103521 0.992509306 -0.010847466 0.974965283 1 27.27323803 28.2349628 4140 microtubule affinity regulating kinase 3 "GO:0000165,GO:0000226,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0018105,GO:0030425,GO:0032092,GO:0035331,GO:0035556,GO:0036289,GO:0048156,GO:0050321,GO:0070062,GO:0106310,GO:0106311" MAPK cascade|microtubule cytoskeleton organization|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|peptidyl-serine phosphorylation|dendrite|positive regulation of protein binding|negative regulation of hippo signaling|intracellular signal transduction|peptidyl-serine autophosphorylation|tau protein binding|tau-protein kinase activity|extracellular exosome|protein serine kinase activity|protein threonine kinase activity MARK4 970.2865198 794.7105232 1145.862516 1.441861512 0.527932603 0.136443993 1 11.05749572 16.63015354 57787 microtubule affinity regulating kinase 4 "GO:0000226,GO:0000930,GO:0001578,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0006468,GO:0007049,GO:0007399,GO:0008017,GO:0015630,GO:0030425,GO:0030496,GO:0035556,GO:0036064,GO:0043005,GO:0043015,GO:0043068,GO:0043130,GO:0044782,GO:0045724,GO:0046605,GO:0048156,GO:0050321,GO:0051301,GO:0097711,GO:0106310,GO:0106311,GO:1904781" microtubule cytoskeleton organization|gamma-tubulin complex|microtubule bundle formation|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|centrosome|microtubule organizing center|cytosol|protein phosphorylation|cell cycle|nervous system development|microtubule binding|microtubule cytoskeleton|dendrite|midbody|intracellular signal transduction|ciliary basal body|neuron projection|gamma-tubulin binding|positive regulation of programmed cell death|ubiquitin binding|cilium organization|positive regulation of cilium assembly|regulation of centrosome cycle|tau protein binding|tau-protein kinase activity|cell division|ciliary basal body-plasma membrane docking|protein serine kinase activity|protein threonine kinase activity|positive regulation of protein localization to centrosome MARS1 4212.167707 3513.777563 4910.557852 1.397515285 0.482864062 0.130758951 1 63.62546932 92.74777401 4141 methionyl-tRNA synthetase 1 "GO:0000049,GO:0004825,GO:0005524,GO:0005730,GO:0005737,GO:0005829,GO:0006418,GO:0006431,GO:0009267,GO:0009303,GO:0016020,GO:0017101,GO:0032869,GO:0036120,GO:0070062,GO:0071364,GO:1901838" tRNA binding|methionine-tRNA ligase activity|ATP binding|nucleolus|cytoplasm|cytosol|tRNA aminoacylation for protein translation|methionyl-tRNA aminoacylation|cellular response to starvation|rRNA transcription|membrane|aminoacyl-tRNA synthetase multienzyme complex|cellular response to insulin stimulus|cellular response to platelet-derived growth factor stimulus|extracellular exosome|cellular response to epidermal growth factor stimulus|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I "hsa00450,hsa00970" Selenocompound metabolism|Aminoacyl-tRNA biosynthesis MARS2 162.4186871 191.826678 133.0106962 0.693389979 -0.528261108 0.361250354 1 3.209562114 2.321342782 92935 "methionyl-tRNA synthetase 2, mitochondrial" "GO:0004825,GO:0005524,GO:0005759,GO:0006418,GO:0006431" methionine-tRNA ligase activity|ATP binding|mitochondrial matrix|tRNA aminoacylation for protein translation|methionyl-tRNA aminoacylation "hsa00450,hsa00970" Selenocompound metabolism|Aminoacyl-tRNA biosynthesis MARVELD1 4353.249062 4132.900703 4573.597422 1.106631335 0.14617468 0.647462696 1 65.1468536 75.19904729 83742 MARVEL domain containing 1 "GO:0005634,GO:0005737,GO:0005856,GO:0005886,GO:0007049,GO:0016021,GO:0019911,GO:0042552" nucleus|cytoplasm|cytoskeleton|plasma membrane|cell cycle|integral component of membrane|structural constituent of myelin sheath|myelination MARVELD2 91.8913715 85.25630134 98.52644165 1.155649965 0.208704486 0.77637413 1 0.935426971 1.127592368 153562 MARVEL domain containing 2 "GO:0005515,GO:0005737,GO:0005923,GO:0007605,GO:0016021,GO:0016323,GO:0016324,GO:0030054,GO:0031410,GO:0033010,GO:0043220,GO:0045216,GO:0061028,GO:0061689,GO:0070830" protein binding|cytoplasm|bicellular tight junction|sensory perception of sound|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cell junction|cytoplasmic vesicle|paranodal junction|Schmidt-Lanterman incisure|cell-cell junction organization|establishment of endothelial barrier|tricellular tight junction|bicellular tight junction assembly hsa04530 Tight junction MAST1 190.5014446 158.3331311 222.6697581 1.406337111 0.491942462 0.370364043 1 1.652382964 2.423907686 22983 microtubule associated serine/threonine kinase 1 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005856,GO:0005886,GO:0006468,GO:0007010,GO:0007420,GO:0008017,GO:0018105,GO:0030424,GO:0030425,GO:0035556,GO:0043005,GO:0043025,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytoskeleton|plasma membrane|protein phosphorylation|cytoskeleton organization|brain development|microtubule binding|peptidyl-serine phosphorylation|axon|dendrite|intracellular signal transduction|neuron projection|neuronal cell body|protein serine kinase activity|protein threonine kinase activity MAST2 2862.805774 2197.379672 3528.231876 1.60565419 0.683161212 0.032405289 0.80591062 14.30272824 23.95448474 23139 microtubule associated serine/threonine kinase 2 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006468,GO:0007010,GO:0008017,GO:0015630,GO:0018105,GO:0019902,GO:0032655,GO:0035556,GO:0048515,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|protein phosphorylation|cytoskeleton organization|microtubule binding|microtubule cytoskeleton|peptidyl-serine phosphorylation|phosphatase binding|regulation of interleukin-12 production|intracellular signal transduction|spermatid differentiation|protein serine kinase activity|protein threonine kinase activity MAST3 359.5200671 329.8606897 389.1794445 1.179829718 0.238578654 0.596499005 1 2.379473046 2.928303257 23031 microtubule associated serine/threonine kinase 3 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0007010,GO:0018105,GO:0035556,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoskeleton organization|peptidyl-serine phosphorylation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity MAST4 409.0059746 345.0850292 472.9269199 1.3704649 0.454665378 0.291817953 1 0.567372398 0.811058258 375449 microtubule associated serine/threonine kinase family member 4 "GO:0000287,GO:0004674,GO:0005524,GO:0005737,GO:0007010,GO:0018105,GO:0035556,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytoskeleton organization|peptidyl-serine phosphorylation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity MASTL 1114.255129 971.3128617 1257.197396 1.294327961 0.372203218 0.282308361 1 9.498661877 12.82397584 84930 microtubule associated serine/threonine kinase like "GO:0000086,GO:0000278,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006974,GO:0016301,GO:0018105,GO:0032154,GO:0032515,GO:0035556,GO:0051301,GO:0051721,GO:0051726,GO:0106310,GO:0106311" G2/M transition of mitotic cell cycle|mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cellular response to DNA damage stimulus|kinase activity|peptidyl-serine phosphorylation|cleavage furrow|negative regulation of phosphoprotein phosphatase activity|intracellular signal transduction|cell division|protein phosphatase 2A binding|regulation of cell cycle|protein serine kinase activity|protein threonine kinase activity MAT2A 4025.78201 4512.494235 3539.069784 0.784282395 -0.35055488 0.271664964 1 81.1295399 66.36932625 4144 methionine adenosyltransferase 2A "GO:0004478,GO:0005515,GO:0005524,GO:0005829,GO:0006556,GO:0006730,GO:0032259,GO:0034214,GO:0042802,GO:0046872,GO:0048269,GO:0051291,GO:1990830" methionine adenosyltransferase activity|protein binding|ATP binding|cytosol|S-adenosylmethionine biosynthetic process|one-carbon metabolic process|methylation|protein hexamerization|identical protein binding|metal ion binding|methionine adenosyltransferase complex|protein heterooligomerization|cellular response to leukemia inhibitory factor hsa00270 Cysteine and methionine metabolism MAT2B 1682.19623 1573.181751 1791.210709 1.13859108 0.187249703 0.567702442 1 32.85612612 39.02114995 27430 methionine adenosyltransferase 2B "GO:0005515,GO:0005634,GO:0005829,GO:0006556,GO:0006730,GO:0019899,GO:0032259,GO:0048269,GO:0048270,GO:0050790,GO:0070062" protein binding|nucleus|cytosol|S-adenosylmethionine biosynthetic process|one-carbon metabolic process|enzyme binding|methylation|methionine adenosyltransferase complex|methionine adenosyltransferase regulator activity|regulation of catalytic activity|extracellular exosome hsa00270 Cysteine and methionine metabolism MATK 7.493403555 7.104691779 7.882115332 1.109423966 0.149810797 1 1 0.123992962 0.143486323 4145 megakaryocyte-associated tyrosine kinase "GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0008284,GO:0016020,GO:0018108,GO:0038128" protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|positive regulation of cell population proliferation|membrane|peptidyl-tyrosine phosphorylation|ERBB2 signaling pathway hsa04722 Neurotrophin signaling pathway MATN1 11.11997832 19.2841634 2.95579325 0.15327568 -2.705799294 0.063130547 1 0.255006487 0.040769972 4146 matrilin 1 "GO:0003429,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0030198,GO:0030500,GO:0031012,GO:0062023,GO:0065003" growth plate cartilage chondrocyte morphogenesis|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|extracellular matrix organization|regulation of bone mineralization|extracellular matrix|collagen-containing extracellular matrix|protein-containing complex assembly MATN2 143.5974644 151.2284393 135.9664895 0.899080161 -0.153478345 0.80779892 1 2.111132014 1.979838366 4147 matrilin 2 "GO:0005201,GO:0005509,GO:0005515,GO:0008150,GO:0031012,GO:0062023" extracellular matrix structural constituent|calcium ion binding|protein binding|biological_process|extracellular matrix|collagen-containing extracellular matrix MATN3 433.2285842 418.161859 448.2953095 1.072061691 0.100387927 0.817396848 1 8.28252756 9.2618682 4148 matrilin 3 "GO:0001501,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005788,GO:0030198,GO:0031012,GO:0043687,GO:0044267,GO:0051216,GO:0062023" skeletal system development|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|endoplasmic reticulum lumen|extracellular matrix organization|extracellular matrix|post-translational protein modification|cellular protein metabolic process|cartilage development|collagen-containing extracellular matrix MATN4 6.493293363 6.08973581 6.896850916 1.132536966 0.17955814 1 1 0.128724389 0.152064961 8785 matrilin 4 "GO:0005509,GO:0005515,GO:0005576,GO:0030198,GO:0062023" calcium ion binding|protein binding|extracellular region|extracellular matrix organization|collagen-containing extracellular matrix MATR3 5713.514969 5554.854015 5872.175923 1.057125157 0.080146193 0.804621092 1 52.87234721 58.30031868 9782 matrin 3 "GO:0002218,GO:0003170,GO:0003281,GO:0003723,GO:0003729,GO:0005198,GO:0005515,GO:0005634,GO:0005637,GO:0006417,GO:0008270,GO:0010608,GO:0016020,GO:0016363,GO:0035198,GO:0042802,GO:0045087" activation of innate immune response|heart valve development|ventricular septum development|RNA binding|mRNA binding|structural molecule activity|protein binding|nucleus|nuclear inner membrane|regulation of translation|zinc ion binding|posttranscriptional regulation of gene expression|membrane|nuclear matrix|miRNA binding|identical protein binding|innate immune response hsa05014 Amyotrophic lateral sclerosis MAU2 849.0787076 860.6826612 837.4747541 0.973035466 -0.039435705 0.916749608 1 8.392479877 8.517946506 23383 MAU2 sister chromatid cohesion factor "GO:0000785,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0016604,GO:0032116,GO:0034088,GO:0047485,GO:0051301,GO:0071921,GO:0090694" chromatin|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|nuclear body|SMC loading complex|maintenance of mitotic sister chromatid cohesion|protein N-terminus binding|cell division|cohesin loading|Scc2-Scc4 cohesin loading complex MAVS 9406.434967 8865.640384 9947.229549 1.121997861 0.166069926 0.619878111 1 37.87544575 44.32673174 57506 mitochondrial antiviral signaling protein "GO:0001934,GO:0002218,GO:0002230,GO:0002735,GO:0005515,GO:0005739,GO:0005741,GO:0005778,GO:0007165,GO:0016021,GO:0016032,GO:0019901,GO:0031966,GO:0032480,GO:0032727,GO:0032728,GO:0032755,GO:0032757,GO:0032760,GO:0035591,GO:0042307,GO:0042742,GO:0043123,GO:0045071,GO:0045087,GO:0045944,GO:0050700,GO:0051091,GO:0051607,GO:0060340,GO:0060760,GO:0071360,GO:0071651,GO:0071660,GO:1900063" positive regulation of protein phosphorylation|activation of innate immune response|positive regulation of defense response to virus by host|positive regulation of myeloid dendritic cell cytokine production|protein binding|mitochondrion|mitochondrial outer membrane|peroxisomal membrane|signal transduction|integral component of membrane|viral process|protein kinase binding|mitochondrial membrane|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|signaling adaptor activity|positive regulation of protein import into nucleus|defense response to bacterium|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|innate immune response|positive regulation of transcription by RNA polymerase II|CARD domain binding|positive regulation of DNA-binding transcription factor activity|defense response to virus|positive regulation of type I interferon-mediated signaling pathway|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of IP-10 production|regulation of peroxisome organization "hsa04621,hsa04622,hsa04623,hsa05160,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05171" NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 MAX 1294.246509 1320.457715 1268.035304 0.960299819 -0.05844319 0.864829363 1 21.02374252 21.05876051 4149 MYC associated factor X "GO:0000082,GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0009267,GO:0016605,GO:0030425,GO:0032868,GO:0032993,GO:0042802,GO:0044877,GO:0045944,GO:0046983,GO:0048678,GO:0051402,GO:0060041,GO:0065003,GO:0070317,GO:0070888,GO:0071339,GO:0071375,GO:0090575,GO:1990837" "G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|cellular response to starvation|PML body|dendrite|response to insulin|protein-DNA complex|identical protein binding|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|protein dimerization activity|response to axon injury|neuron apoptotic process|retina development in camera-type eye|protein-containing complex assembly|negative regulation of G0 to G1 transition|E-box binding|MLL1 complex|cellular response to peptide hormone stimulus|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa04010,hsa05200,hsa05202,hsa05222" MAPK signaling pathway|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer bHLH MAZ 3517.221768 3221.470244 3812.973292 1.183612762 0.243197157 0.444742759 1 56.94802903 70.3079227 4150 MYC associated zinc finger protein "GO:0000122,GO:0000978,GO:0000981,GO:0003700,GO:0003723,GO:0005515,GO:0005634,GO:0006357,GO:0006367,GO:0006369,GO:0008284,GO:0010628,GO:0014068,GO:0030335,GO:0045893,GO:0046872,GO:0051897,GO:2001234" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|RNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|termination of RNA polymerase II transcription|positive regulation of cell population proliferation|positive regulation of gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of cell migration|positive regulation of transcription, DNA-templated|metal ion binding|positive regulation of protein kinase B signaling|negative regulation of apoptotic signaling pathway" zf-C2H2 MB 4.059823873 8.119647747 0 0 #NAME? 0.065967888 1 0.230252807 0 4151 myoglobin "GO:0005344,GO:0005829,GO:0009725,GO:0015671,GO:0019825,GO:0020037,GO:0031444,GO:0042542,GO:0046872,GO:0070062" oxygen carrier activity|cytosol|response to hormone|oxygen transport|oxygen binding|heme binding|slow-twitch skeletal muscle fiber contraction|response to hydrogen peroxide|metal ion binding|extracellular exosome MB21D2 264.3381305 322.7559979 205.9202631 0.638005999 -0.648358104 0.188215856 1 5.336745896 3.551544145 151963 Mab-21 domain containing 2 "GO:0005515,GO:0044877,GO:0045296" protein binding|protein-containing complex binding|cadherin binding MBD1 1438.05602 1250.425753 1625.686287 1.300106211 0.378629487 0.256124777 1 15.75364506 21.36366794 4152 methyl-CpG binding domain protein 1 "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006366,GO:0008270,GO:0008327,GO:0010385,GO:0016363,GO:0016607,GO:0045322,GO:0045892" "DNA binding|protein binding|nucleus|nucleoplasm|chromosome|transcription by RNA polymerase II|zinc ion binding|methyl-CpG binding|double-stranded methylated DNA binding|nuclear matrix|nuclear speck|unmethylated CpG binding|negative regulation of transcription, DNA-templated" MBD2 1256.394739 1427.028092 1085.761387 0.76085495 -0.394306652 0.245829311 1 13.15027995 10.43645004 8932 methyl-CpG binding domain protein 2 "GO:0000118,GO:0000122,GO:0000183,GO:0000785,GO:0000792,GO:0003696,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006346,GO:0007507,GO:0007568,GO:0008327,GO:0009612,GO:0019904,GO:0030177,GO:0031492,GO:0031667,GO:0032355,GO:0032991,GO:0034622,GO:0035197,GO:0035563,GO:0042127,GO:0042711,GO:0043044,GO:0044030,GO:0045892,GO:0048568,GO:0070742,GO:0071407" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|rDNA heterochromatin assembly|chromatin|heterochromatin|satellite DNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA methylation-dependent heterochromatin assembly|heart development|aging|methyl-CpG binding|response to mechanical stimulus|protein domain specific binding|positive regulation of Wnt signaling pathway|nucleosomal DNA binding|response to nutrient levels|response to estradiol|protein-containing complex|cellular protein-containing complex assembly|siRNA binding|positive regulation of chromatin binding|regulation of cell population proliferation|maternal behavior|ATP-dependent chromatin remodeling|regulation of DNA methylation|negative regulation of transcription, DNA-templated|embryonic organ development|C2H2 zinc finger domain binding|cellular response to organic cyclic compound" chromosome_remodelling_factor MBD3 2197.745611 2095.884075 2299.607148 1.097201499 0.133828498 0.676898948 1 18.69481059 21.39554686 53615 methyl-CpG binding domain protein 3 "GO:0000122,GO:0000785,GO:0000792,GO:0001701,GO:0003677,GO:0005515,GO:0005654,GO:0005737,GO:0006346,GO:0007420,GO:0007507,GO:0007568,GO:0008327,GO:0009888,GO:0016573,GO:0016581,GO:0031492,GO:0031667,GO:0032355,GO:0032991,GO:0043044,GO:0044030,GO:0048568,GO:1901796" negative regulation of transcription by RNA polymerase II|chromatin|heterochromatin|in utero embryonic development|DNA binding|protein binding|nucleoplasm|cytoplasm|DNA methylation-dependent heterochromatin assembly|brain development|heart development|aging|methyl-CpG binding|tissue development|histone acetylation|NuRD complex|nucleosomal DNA binding|response to nutrient levels|response to estradiol|protein-containing complex|ATP-dependent chromatin remodeling|regulation of DNA methylation|embryonic organ development|regulation of signal transduction by p53 class mediator MBD MBD4 500.2359671 486.1639089 514.3080254 1.057890181 0.08118987 0.846773131 1 7.380841397 8.144461767 8930 "methyl-CpG binding domain 4, DNA glycosylase" "GO:0003677,GO:0003696,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0008263,GO:0016607,GO:0019104,GO:0032355,GO:0045008" DNA binding|satellite DNA binding|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|DNA repair|pyrimidine-specific mismatch base pair DNA N-glycosylase activity|nuclear speck|DNA N-glycosylase activity|response to estradiol|depyrimidination hsa03410 Base excision repair MBD MBD5 380.5993317 322.7559979 438.4426654 1.358433827 0.441944289 0.315586306 1 1.500913845 2.126719342 55777 methyl-CpG binding domain protein 5 "GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005694,GO:0007399,GO:0010369,GO:0016579,GO:0030496,GO:0040014,GO:0042593,GO:0050795,GO:0060399,GO:0070062" DNA binding|chromatin binding|nucleus|nucleoplasm|chromosome|nervous system development|chromocenter|protein deubiquitination|midbody|regulation of multicellular organism growth|glucose homeostasis|regulation of behavior|positive regulation of growth hormone receptor signaling pathway|extracellular exosome MBD6 1051.77051 909.4005477 1194.140473 1.313107273 0.39298478 0.260812396 1 9.413024641 12.89274319 114785 methyl-CpG binding domain protein 6 "GO:0001650,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0010369,GO:0016579" fibrillar center|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|chromocenter|protein deubiquitination MBIP 355.3711686 315.6513062 395.091031 1.251669242 0.323853375 0.472177795 1 9.935752086 12.97197958 51562 MAP3K12 binding inhibitory protein 1 "GO:0000173,GO:0004860,GO:0005515,GO:0005654,GO:0005671,GO:0005730,GO:0005829,GO:0042802,GO:0043966" inactivation of MAPK activity involved in osmosensory signaling pathway|protein kinase inhibitor activity|protein binding|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|nucleolus|cytosol|identical protein binding|histone H3 acetylation MBLAC1 42.00462808 42.62815067 41.38110549 0.970745971 -0.042834281 0.99205358 1 1.400107295 1.41769512 255374 metallo-beta-lactamase domain containing 1 "GO:0016787,GO:0046872" hydrolase activity|metal ion binding MBLAC2 156.1656478 168.4826908 143.8486048 0.853788625 -0.228049154 0.703204706 1 1.995102622 1.776771312 153364 metallo-beta-lactamase domain containing 2 "GO:0003674,GO:0005515,GO:0008150,GO:0016787,GO:0046872,GO:0070062" molecular_function|protein binding|biological_process|hydrolase activity|metal ion binding|extracellular exosome MBNL1 2770.202797 2602.347103 2938.05849 1.129003309 0.175049714 0.582844143 1 17.81317749 20.97744252 4154 muscleblind like splicing regulator 1 "GO:0000381,GO:0001701,GO:0003723,GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0007399,GO:0008380,GO:0010494,GO:0030326,GO:0043484,GO:0045445,GO:0046872" "regulation of alternative mRNA splicing, via spliceosome|in utero embryonic development|RNA binding|double-stranded RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|nervous system development|RNA splicing|cytoplasmic stress granule|embryonic limb morphogenesis|regulation of RNA splicing|myoblast differentiation|metal ion binding" MBNL2 967.7706567 892.1462962 1043.395017 1.169533541 0.225933238 0.524630556 1 6.382831276 7.786494401 10150 muscleblind like splicing regulator 2 "GO:0000381,GO:0003723,GO:0005654,GO:0005737,GO:0006397,GO:0008380,GO:0043484,GO:0046872,GO:1990837" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|nucleoplasm|cytoplasm|mRNA processing|RNA splicing|regulation of RNA splicing|metal ion binding|sequence-specific double-stranded DNA binding" MBOAT1 139.0746999 145.1387035 133.0106962 0.916438504 -0.125890021 0.846207706 1 1.295288689 1.238185833 154141 membrane bound O-acyltransferase domain containing 1 "GO:0005789,GO:0008654,GO:0010975,GO:0016020,GO:0016021,GO:0016746,GO:0030258,GO:0036150,GO:0036152,GO:0047184,GO:0106262,GO:0106263" "endoplasmic reticulum membrane|phospholipid biosynthetic process|regulation of neuron projection development|membrane|integral component of membrane|transferase activity, transferring acyl groups|lipid modification|phosphatidylserine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|1-acylglycerophosphocholine O-acyltransferase activity|1-acylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphoserine O-acyltransferase activity" "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism MBOAT2 743.1857934 761.2169763 725.1546106 0.952625379 -0.070019111 0.854253175 1 4.947126195 4.915764467 129642 membrane bound O-acyltransferase domain containing 2 "GO:0003841,GO:0005789,GO:0008654,GO:0016020,GO:0016021,GO:0016746,GO:0030258,GO:0032330,GO:0036150,GO:0036151,GO:0036152,GO:0047184,GO:0106262,GO:0106263" "1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum membrane|phospholipid biosynthetic process|membrane|integral component of membrane|transferase activity, transferring acyl groups|lipid modification|regulation of chondrocyte differentiation|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|1-acylglycerophosphocholine O-acyltransferase activity|1-acylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphoserine O-acyltransferase activity" "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism MBOAT7 2118.009217 2336.428639 1899.589795 0.813031378 -0.298617063 0.352465758 1 38.91215658 32.99958949 79143 membrane bound O-acyltransferase domain containing 7 "GO:0003841,GO:0005515,GO:0005783,GO:0005789,GO:0006661,GO:0008374,GO:0016020,GO:0016021,GO:0016746,GO:0021591,GO:0021819,GO:0030258,GO:0036149,GO:0036151,GO:0044233,GO:0047144,GO:0071617,GO:0090207" "1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|phosphatidylinositol biosynthetic process|O-acyltransferase activity|membrane|integral component of membrane|transferase activity, transferring acyl groups|ventricular system development|layer formation in cerebral cortex|lipid modification|phosphatidylinositol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|mitochondria-associated endoplasmic reticulum membrane|2-acylglycerol-3-phosphate O-acyltransferase activity|lysophospholipid acyltransferase activity|regulation of triglyceride metabolic process" hsa00564 Glycerophospholipid metabolism MBP 680.0452393 688.1401466 671.9503321 0.976473085 -0.034347815 0.931973818 1 2.544675147 2.591842191 4155 myelin basic protein "GO:0000165,GO:0002020,GO:0005515,GO:0005516,GO:0005634,GO:0005886,GO:0006955,GO:0007268,GO:0007417,GO:0007605,GO:0008366,GO:0009636,GO:0009986,GO:0019911,GO:0021762,GO:0032755,GO:0032991,GO:0033269,GO:0034115,GO:0035633,GO:0042552,GO:0043025,GO:0043209,GO:0043218,GO:0045202,GO:0061024,GO:0071944,GO:1904685,GO:2000343" MAPK cascade|protease binding|protein binding|calmodulin binding|nucleus|plasma membrane|immune response|chemical synaptic transmission|central nervous system development|sensory perception of sound|axon ensheathment|response to toxic substance|cell surface|structural constituent of myelin sheath|substantia nigra development|positive regulation of interleukin-6 production|protein-containing complex|internode region of axon|negative regulation of heterotypic cell-cell adhesion|maintenance of blood-brain barrier|myelination|neuronal cell body|myelin sheath|compact myelin|synapse|membrane organization|cell periphery|positive regulation of metalloendopeptidase activity|positive regulation of chemokine (C-X-C motif) ligand 2 production MBTD1 388.4908496 390.7580478 386.2236513 0.988395897 -0.016839073 0.975815823 1 3.378374293 3.483009248 54799 mbt domain containing 1 "GO:0003682,GO:0005515,GO:0005634,GO:0006325,GO:0008270,GO:0035064,GO:0042393,GO:0045892,GO:0048706" "chromatin binding|protein binding|nucleus|chromatin organization|zinc ion binding|methylated histone binding|histone binding|negative regulation of transcription, DNA-templated|embryonic skeletal system development" MBTPS1 3148.955563 3236.694583 3061.216542 0.945784801 -0.080416137 0.801097827 1 31.61565328 31.18964419 8720 "membrane bound transcription factor peptidase, site 1" "GO:0000139,GO:0004252,GO:0005788,GO:0005789,GO:0005794,GO:0005795,GO:0006508,GO:0006606,GO:0007040,GO:0008203,GO:0016021,GO:0030968,GO:0031293,GO:0034976,GO:0036500,GO:0043687,GO:0044267,GO:0045540,GO:0060627" Golgi membrane|serine-type endopeptidase activity|endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi apparatus|Golgi stack|proteolysis|protein import into nucleus|lysosome organization|cholesterol metabolic process|integral component of membrane|endoplasmic reticulum unfolded protein response|membrane protein intracellular domain proteolysis|response to endoplasmic reticulum stress|ATF6-mediated unfolded protein response|post-translational protein modification|cellular protein metabolic process|regulation of cholesterol biosynthetic process|regulation of vesicle-mediated transport hsa04141 Protein processing in endoplasmic reticulum MBTPS2 1135.214143 1158.06476 1112.363526 0.960536548 -0.058087587 0.868601329 1 13.19205908 13.21728977 51360 "membrane bound transcription factor peptidase, site 2" "GO:0000139,GO:0004222,GO:0005737,GO:0005789,GO:0008203,GO:0016021,GO:0030968,GO:0031293,GO:0034976,GO:0036500,GO:0045540,GO:0046872,GO:0051091,GO:0070977,GO:1905897,GO:1990440" Golgi membrane|metalloendopeptidase activity|cytoplasm|endoplasmic reticulum membrane|cholesterol metabolic process|integral component of membrane|endoplasmic reticulum unfolded protein response|membrane protein intracellular domain proteolysis|response to endoplasmic reticulum stress|ATF6-mediated unfolded protein response|regulation of cholesterol biosynthetic process|metal ion binding|positive regulation of DNA-binding transcription factor activity|bone maturation|regulation of response to endoplasmic reticulum stress|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress hsa04141 Protein processing in endoplasmic reticulum MC1R 43.19773336 56.83753423 29.5579325 0.520042484 -0.943298608 0.289985838 1 1.363628895 0.739692047 4157 melanocortin 1 receptor "GO:0004930,GO:0004977,GO:0004980,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007189,GO:0007275,GO:0008528,GO:0009650,GO:0010739,GO:0019222,GO:0031625,GO:0032720,GO:0035556,GO:0043473,GO:0045944,GO:0051897,GO:0070914,GO:0090037" "G protein-coupled receptor activity|melanocortin receptor activity|melanocyte-stimulating hormone receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-activating G protein-coupled receptor signaling pathway|multicellular organism development|G protein-coupled peptide receptor activity|UV protection|positive regulation of protein kinase A signaling|regulation of metabolic process|ubiquitin protein ligase binding|negative regulation of tumor necrosis factor production|intracellular signal transduction|pigmentation|positive regulation of transcription by RNA polymerase II|positive regulation of protein kinase B signaling|UV-damage excision repair|positive regulation of protein kinase C signaling" "hsa04080,hsa04916" Neuroactive ligand-receptor interaction|Melanogenesis MC4R 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.089971889 0 4160 melanocortin 4 receptor "GO:0002024,GO:0004930,GO:0004977,GO:0004980,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0006112,GO:0007186,GO:0007188,GO:0007189,GO:0007631,GO:0016021,GO:0017046,GO:0019222,GO:0031625,GO:0042923,GO:0045780,GO:2000252,GO:2000821" diet induced thermogenesis|G protein-coupled receptor activity|melanocortin receptor activity|melanocyte-stimulating hormone receptor activity|protein binding|nucleus|cytoplasm|plasma membrane|energy reserve metabolic process|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|feeding behavior|integral component of membrane|peptide hormone binding|regulation of metabolic process|ubiquitin protein ligase binding|neuropeptide binding|positive regulation of bone resorption|negative regulation of feeding behavior|regulation of grooming behavior hsa04080 Neuroactive ligand-receptor interaction MCAM 5125.534553 5940.537283 4310.531822 0.725613125 -0.462727543 0.150553719 1 49.34676996 37.34906982 4162 melanoma cell adhesion molecule "GO:0001525,GO:0003094,GO:0005576,GO:0005615,GO:0005634,GO:0005886,GO:0005925,GO:0007155,GO:0009653,GO:0009897,GO:0016021,GO:0030335,GO:0061042" angiogenesis|glomerular filtration|extracellular region|extracellular space|nucleus|plasma membrane|focal adhesion|cell adhesion|anatomical structure morphogenesis|external side of plasma membrane|integral component of membrane|positive regulation of cell migration|vascular wound healing MCAT 404.9676775 439.4759343 370.4594206 0.84295724 -0.246468644 0.57063793 1 10.62937235 9.34607142 27349 malonyl-CoA-acyl carrier protein transacylase "GO:0003723,GO:0004312,GO:0004314,GO:0005739,GO:0005759,GO:0006633,GO:0006635" RNA binding|fatty acid synthase activity|[acyl-carrier-protein] S-malonyltransferase activity|mitochondrion|mitochondrial matrix|fatty acid biosynthetic process|fatty acid beta-oxidation hsa00061 Fatty acid biosynthesis MCC 299.1814053 313.6213942 284.7414164 0.907914516 -0.139371627 0.773649689 1 0.595100117 0.563573969 4163 MCC regulator of WNT signaling pathway "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0010633,GO:0016055,GO:0030027,GO:0036464,GO:0038023,GO:0045184,GO:0050680,GO:0090090" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|signal transduction|negative regulation of epithelial cell migration|Wnt signaling pathway|lamellipodium|cytoplasmic ribonucleoprotein granule|signaling receptor activity|establishment of protein localization|negative regulation of epithelial cell proliferation|negative regulation of canonical Wnt signaling pathway MCCC1 602.6898584 653.6316436 551.7480733 0.844126931 -0.244468142 0.532664286 1 10.06816815 8.864906227 56922 methylcrotonoyl-CoA carboxylase 1 "GO:0002169,GO:0004075,GO:0004485,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006552,GO:0006768,GO:0009083,GO:0009374,GO:0016421,GO:0046872,GO:1905202" "3-methylcrotonyl-CoA carboxylase complex, mitochondrial|biotin carboxylase activity|methylcrotonoyl-CoA carboxylase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|leucine catabolic process|biotin metabolic process|branched-chain amino acid catabolic process|biotin binding|CoA carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase complex" hsa00280 "Valine, leucine and isoleucine degradation" MCCC2 1464.244953 1558.972367 1369.517539 0.878474544 -0.186927614 0.57470646 1 18.72781088 17.16058647 64087 methylcrotonoyl-CoA carboxylase 2 "GO:0002169,GO:0004485,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006552,GO:0006768,GO:0009083,GO:0015936,GO:1905202" "3-methylcrotonyl-CoA carboxylase complex, mitochondrial|methylcrotonoyl-CoA carboxylase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|leucine catabolic process|biotin metabolic process|branched-chain amino acid catabolic process|coenzyme A metabolic process|methylcrotonoyl-CoA carboxylase complex" hsa00280 "Valine, leucine and isoleucine degradation" MCEE 59.49913356 59.88240213 59.11586499 0.987199292 -0.018586735 1 1 3.667270152 3.776275481 84693 methylmalonyl-CoA epimerase "GO:0004493,GO:0005515,GO:0005759,GO:0019626,GO:0046491,GO:0046872" methylmalonyl-CoA epimerase activity|protein binding|mitochondrial matrix|short-chain fatty acid catabolic process|L-methylmalonyl-CoA metabolic process|metal ion binding "hsa00280,hsa00630,hsa00640" "Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism" MCF2 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.032302434 0.010902736 4168 MCF.2 cell line derived transforming sequence "GO:0005085,GO:0005515,GO:0005829,GO:0005856,GO:0007186,GO:0016020,GO:0035556,GO:0043065,GO:0050771,GO:0050790,GO:0051056" guanyl-nucleotide exchange factor activity|protein binding|cytosol|cytoskeleton|G protein-coupled receptor signaling pathway|membrane|intracellular signal transduction|positive regulation of apoptotic process|negative regulation of axonogenesis|regulation of catalytic activity|regulation of small GTPase mediated signal transduction MCF2L2 126.4201634 88.30116925 164.5391576 1.863385943 0.897926515 0.153222975 1 0.362557172 0.704685354 23101 MCF.2 cell line derived transforming sequence-like 2 "GO:0005085,GO:0050790" guanyl-nucleotide exchange factor activity|regulation of catalytic activity MCFD2 5462.638736 4906.297151 6018.980321 1.226786747 0.294884486 0.360779506 1 55.77702409 71.37405064 90411 "multiple coagulation factor deficiency 2, ER cargo receptor complex subunit" "GO:0000139,GO:0005509,GO:0005515,GO:0005789,GO:0006888,GO:0012507,GO:0015031,GO:0018279,GO:0033116,GO:0048208" Golgi membrane|calcium ion binding|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|protein transport|protein N-linked glycosylation via asparagine|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating MCIDAS 86.48726298 86.27125731 86.70326866 1.005007593 0.007206401 1 1 1.501489634 1.574010449 345643 multiciliate differentiation and DNA synthesis associated cell cycle protein "GO:0003713,GO:0005515,GO:0005634,GO:0005730,GO:0007049,GO:0007346,GO:0008156,GO:0016604,GO:0042802,GO:0044458,GO:0045786,GO:0045944,GO:0060271,GO:0098534,GO:1902017,GO:1903251" transcription coactivator activity|protein binding|nucleus|nucleolus|cell cycle|regulation of mitotic cell cycle|negative regulation of DNA replication|nuclear body|identical protein binding|motile cilium assembly|negative regulation of cell cycle|positive regulation of transcription by RNA polymerase II|cilium assembly|centriole assembly|regulation of cilium assembly|multi-ciliated epithelial cell differentiation MCL1 8388.478175 7573.601436 9203.354915 1.215188704 0.281180364 0.396822218 1 97.10789739 123.0875718 4170 "MCL1 apoptosis regulator, BCL2 family member" "GO:0001709,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0007275,GO:0008320,GO:0008630,GO:0010507,GO:0016020,GO:0016021,GO:0019221,GO:0019725,GO:0034097,GO:0042803,GO:0043066,GO:0046982,GO:0051434,GO:0071806,GO:0097136,GO:0097192,GO:1903378,GO:2000811,GO:2001020,GO:2001240,GO:2001243" cell fate determination|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|multicellular organism development|protein transmembrane transporter activity|intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of autophagy|membrane|integral component of membrane|cytokine-mediated signaling pathway|cellular homeostasis|response to cytokine|protein homodimerization activity|negative regulation of apoptotic process|protein heterodimerization activity|BH3 domain binding|protein transmembrane transport|Bcl-2 family protein complex|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|negative regulation of anoikis|regulation of response to DNA damage stimulus|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway "hsa04151,hsa04210,hsa04630,hsa05206" PI3K-Akt signaling pathway|Apoptosis|JAK-STAT signaling pathway|MicroRNAs in cancer MCM10 704.22059 791.6656553 616.7755248 0.779085869 -0.360145748 0.339992726 1 8.763950298 7.121986772 55388 minichromosome maintenance 10 replication initiation factor "GO:0000082,GO:0003688,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006260,GO:0006270,GO:0006974,GO:0008283,GO:0019899,GO:0031298,GO:0042802,GO:0046872" G1/S transition of mitotic cell cycle|DNA replication origin binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|DNA replication|DNA replication initiation|cellular response to DNA damage stimulus|cell population proliferation|enzyme binding|replication fork protection complex|identical protein binding|metal ion binding MCM2 2695.553306 2887.54973 2503.556882 0.867017754 -0.205866558 0.518372584 1 41.51127084 37.54135552 4171 minichromosome maintenance complex component 2 "GO:0000082,GO:0000727,GO:0000781,GO:0000785,GO:0003677,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005664,GO:0005730,GO:0005737,GO:0006260,GO:0006267,GO:0006268,GO:0006270,GO:0006334,GO:0006915,GO:0017116,GO:0019899,GO:0042393,GO:0042555,GO:0043138,GO:0046872,GO:0071162,GO:0071353,GO:0090102,GO:1902975,GO:1905775" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|chromatin|DNA binding|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|nucleolus|cytoplasm|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|nucleosome assembly|apoptotic process|single-stranded DNA helicase activity|enzyme binding|histone binding|MCM complex|3'-5' DNA helicase activity|metal ion binding|CMG complex|cellular response to interleukin-4|cochlea development|mitotic DNA replication initiation|negative regulation of DNA helicase activity" "hsa03030,hsa04110" DNA replication|Cell cycle MCM3 2550.656341 2378.041834 2723.270847 1.14517365 0.19556638 0.540019301 1 35.91990148 42.90643319 4172 minichromosome maintenance complex component 3 "GO:0000082,GO:0000727,GO:0000781,GO:0003677,GO:0003678,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005658,GO:0005730,GO:0005813,GO:0006260,GO:0006267,GO:0006270,GO:0006271,GO:0016020,GO:0032508,GO:0042555,GO:0048471,GO:0071162,GO:1902975" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|DNA binding|DNA helicase activity|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|alpha DNA polymerase:primase complex|nucleolus|centrosome|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|membrane|DNA duplex unwinding|MCM complex|perinuclear region of cytoplasm|CMG complex|mitotic DNA replication initiation" "hsa03030,hsa04110" DNA replication|Cell cycle MCM3AP 2435.306175 2372.967054 2497.645296 1.052541076 0.073876536 0.817979192 1 17.15666095 18.83595967 8888 minichromosome maintenance complex component 3 associated protein "GO:0003676,GO:0003682,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006406,GO:0010484,GO:0016446,GO:0016973,GO:0031965,GO:0034728,GO:0042393,GO:0043966,GO:0044615,GO:0070390" nucleic acid binding|chromatin binding|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|mRNA export from nucleus|H3 histone acetyltransferase activity|somatic hypermutation of immunoglobulin genes|poly(A)+ mRNA export from nucleus|nuclear membrane|nucleosome organization|histone binding|histone H3 acetylation|nuclear pore nuclear basket|transcription export complex 2 MCM4 8189.678442 8127.767395 8251.589489 1.015234453 0.021812935 0.947847575 1 101.3399177 107.3155917 4173 minichromosome maintenance complex component 4 "GO:0000082,GO:0000727,GO:0000781,GO:0003678,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006260,GO:0006267,GO:0006268,GO:0006271,GO:0016020,GO:0042555,GO:0071162,GO:1902975" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|DNA helicase activity|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication|DNA strand elongation involved in DNA replication|membrane|MCM complex|CMG complex|mitotic DNA replication initiation" "hsa03030,hsa04110" DNA replication|Cell cycle MCM5 2671.249787 2707.902524 2634.59705 0.972929057 -0.039593482 0.902205925 1 33.41757064 33.91345048 4174 minichromosome maintenance complex component 5 "GO:0000082,GO:0000727,GO:0000781,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006267,GO:0006270,GO:0016020,GO:0017116,GO:0032508,GO:0042555,GO:0043138,GO:0071162" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA replication initiation|membrane|single-stranded DNA helicase activity|DNA duplex unwinding|MCM complex|3'-5' DNA helicase activity|CMG complex" "hsa03030,hsa04110" DNA replication|Cell cycle MCM6 1223.650408 1141.825464 1305.475352 1.143323032 0.193233077 0.571792124 1 15.40885469 18.37618023 4175 minichromosome maintenance complex component 6 "GO:0000082,GO:0000727,GO:0000781,GO:0003678,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006260,GO:0006267,GO:0006268,GO:0006270,GO:0042555,GO:0042802,GO:0071162,GO:1902969,GO:1990518" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|DNA helicase activity|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|MCM complex|identical protein binding|CMG complex|mitotic DNA replication|single-stranded 3'-5' DNA helicase activity" "hsa03030,hsa04110" DNA replication|Cell cycle MCM7 5961.84218 5422.909739 6500.77462 1.198761354 0.261544479 0.41997056 1 93.38702734 116.7710579 4176 minichromosome maintenance complex component 7 "GO:0000082,GO:0000727,GO:0000781,GO:0000785,GO:0003677,GO:0003678,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006260,GO:0006267,GO:0006268,GO:0006270,GO:0006271,GO:0006974,GO:0008283,GO:0016020,GO:0042325,GO:0042493,GO:0042555,GO:0071162,GO:0071364,GO:0071466,GO:1990518" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|chromatin|DNA binding|DNA helicase activity|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|cellular response to DNA damage stimulus|cell population proliferation|membrane|regulation of phosphorylation|response to drug|MCM complex|CMG complex|cellular response to epidermal growth factor stimulus|cellular response to xenobiotic stimulus|single-stranded 3'-5' DNA helicase activity" "hsa03030,hsa04110" DNA replication|Cell cycle MCM8 2261.644784 2018.747421 2504.542147 1.240641658 0.311086473 0.331159115 1 9.336356056 12.08202403 84515 minichromosome maintenance 8 homologous recombination repair factor "GO:0000082,GO:0000724,GO:0003678,GO:0003682,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006260,GO:0006974,GO:0007292,GO:0019899,GO:0032406,GO:0032407,GO:0032408,GO:0032508,GO:0036298,GO:0042555,GO:0048232,GO:0050821,GO:0071168,GO:0097362" G1/S transition of mitotic cell cycle|double-strand break repair via homologous recombination|DNA helicase activity|chromatin binding|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|cytosol|DNA replication|cellular response to DNA damage stimulus|female gamete generation|enzyme binding|MutLbeta complex binding|MutSalpha complex binding|MutSbeta complex binding|DNA duplex unwinding|recombinational interstrand cross-link repair|MCM complex|male gamete generation|protein stabilization|protein localization to chromatin|MCM8-MCM9 complex MCM9 104.3259429 93.37594909 115.2759367 1.234535636 0.303968482 0.657012579 1 0.484297226 0.623636524 254394 minichromosome maintenance 9 homologous recombination repair factor "GO:0000724,GO:0003678,GO:0003682,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0006260,GO:0006974,GO:0007292,GO:0019899,GO:0032406,GO:0032407,GO:0032408,GO:0032508,GO:0036298,GO:0042555,GO:0044877,GO:0070716,GO:0071168,GO:0097362" double-strand break repair via homologous recombination|DNA helicase activity|chromatin binding|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|chromosome|DNA replication|cellular response to DNA damage stimulus|female gamete generation|enzyme binding|MutLbeta complex binding|MutSalpha complex binding|MutSbeta complex binding|DNA duplex unwinding|recombinational interstrand cross-link repair|MCM complex|protein-containing complex binding|mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication|protein localization to chromatin|MCM8-MCM9 complex MCMBP 2115.731132 2079.644779 2151.817486 1.034704343 0.049218591 0.879499744 1 23.18949175 25.02784358 79892 minichromosome maintenance complex binding protein "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006261,GO:0007062,GO:0030054,GO:0042555,GO:0051301" chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|DNA-dependent DNA replication|sister chromatid cohesion|cell junction|MCM complex|cell division MCMDC2 8.089956195 14.20938356 1.970528833 0.138677996 -2.850189203 0.088190553 1 0.122682433 0.01774622 157777 minichromosome maintenance domain containing 2 "GO:0000727,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0006267,GO:0006268,GO:0006271,GO:0042555,GO:0051321,GO:1902975" double-strand break repair via break-induced replication|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication|DNA strand elongation involved in DNA replication|MCM complex|meiotic cell cycle|mitotic DNA replication initiation MCOLN1 466.7869575 422.2216828 511.3522322 1.211098939 0.276316729 0.507889635 1 10.26105505 12.96246423 57192 mucolipin TRP cation channel 1 "GO:0001891,GO:0002250,GO:0005261,GO:0005381,GO:0005515,GO:0005654,GO:0005764,GO:0005765,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0006812,GO:0008289,GO:0010008,GO:0016020,GO:0016021,GO:0019722,GO:0030670,GO:0031902,GO:0033572,GO:0034755,GO:0042995,GO:0043231,GO:0043235,GO:0051209,GO:0051289,GO:0070588,GO:0071277,GO:0071467,GO:0072345,GO:0090382,GO:0097352,GO:0097682,GO:0099604" "phagocytic cup|adaptive immune response|cation channel activity|iron ion transmembrane transporter activity|protein binding|nucleoplasm|lysosome|lysosomal membrane|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|cation transport|lipid binding|endosome membrane|membrane|integral component of membrane|calcium-mediated signaling|phagocytic vesicle membrane|late endosome membrane|transferrin transport|iron ion transmembrane transport|cell projection|intracellular membrane-bounded organelle|receptor complex|release of sequestered calcium ion into cytosol|protein homotetramerization|calcium ion transmembrane transport|cellular response to calcium ion|cellular response to pH|NAADP-sensitive calcium-release channel activity|phagosome maturation|autophagosome maturation|intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity|ligand-gated calcium channel activity" "hsa04020,hsa04142" Calcium signaling pathway|Lysosome MCOLN2 101.2041245 115.7049804 86.70326866 0.749347767 -0.416292677 0.542576173 1 1.563096579 1.22175791 255231 mucolipin TRP cation channel 2 "GO:0002250,GO:0005765,GO:0005886,GO:0015031,GO:0016020,GO:0016021,GO:0031902,GO:0042802,GO:0045087,GO:0051209,GO:0055038,GO:0070588,GO:0071639,GO:0071642,GO:0071651,GO:0072345,GO:1905517,GO:1990266,GO:2000343" adaptive immune response|lysosomal membrane|plasma membrane|protein transport|membrane|integral component of membrane|late endosome membrane|identical protein binding|innate immune response|release of sequestered calcium ion into cytosol|recycling endosome membrane|calcium ion transmembrane transport|positive regulation of monocyte chemotactic protein-1 production|positive regulation of macrophage inflammatory protein 1 alpha production|positive regulation of chemokine (C-C motif) ligand 5 production|NAADP-sensitive calcium-release channel activity|macrophage migration|neutrophil migration|positive regulation of chemokine (C-X-C motif) ligand 2 production hsa04020 Calcium signaling pathway MCOLN3 549.1725809 463.8348775 634.5102843 1.367965875 0.452032242 0.257806526 1 6.764065717 9.65159327 55283 mucolipin TRP cation channel 3 "GO:0000421,GO:0005765,GO:0005886,GO:0007626,GO:0008289,GO:0016020,GO:0016021,GO:0031901,GO:0031902,GO:0042491,GO:0051209,GO:0070588,GO:0072345" autophagosome membrane|lysosomal membrane|plasma membrane|locomotory behavior|lipid binding|membrane|integral component of membrane|early endosome membrane|late endosome membrane|inner ear auditory receptor cell differentiation|release of sequestered calcium ion into cytosol|calcium ion transmembrane transport|NAADP-sensitive calcium-release channel activity hsa04020 Calcium signaling pathway MCPH1 368.0135809 337.9803375 398.0468243 1.177721838 0.235998834 0.59792508 1 0.762710501 0.936954246 79648 microcephalin 1 "GO:0000122,GO:0000132,GO:0000278,GO:0005515,GO:0005654,GO:0005737,GO:0005815,GO:0021987,GO:0042802,GO:0043549,GO:0046605,GO:0050727,GO:0060348,GO:0060623,GO:0071539,GO:0071850,GO:0097150" negative regulation of transcription by RNA polymerase II|establishment of mitotic spindle orientation|mitotic cell cycle|protein binding|nucleoplasm|cytoplasm|microtubule organizing center|cerebral cortex development|identical protein binding|regulation of kinase activity|regulation of centrosome cycle|regulation of inflammatory response|bone development|regulation of chromosome condensation|protein localization to centrosome|mitotic cell cycle arrest|neuronal stem cell population maintenance MCRIP1 226.7753571 179.6472064 273.9035078 1.524674462 0.608501241 0.240141719 1 6.966690082 11.07948431 348262 MAPK regulated corepressor interacting protein 1 "GO:0005515,GO:0005634,GO:0005737,GO:0010494,GO:0010717" protein binding|nucleus|cytoplasm|cytoplasmic stress granule|regulation of epithelial to mesenchymal transition MCRIP2 176.3756925 202.9911937 149.7601913 0.737766938 -0.438762958 0.436662911 1 11.04273668 8.497904279 84331 MAPK regulated corepressor interacting protein 2 "GO:0005515,GO:0005634,GO:0005737,GO:0010494" protein binding|nucleus|cytoplasm|cytoplasmic stress granule MCRS1 1544.183745 1399.62428 1688.74321 1.206568958 0.270910371 0.412438574 1 34.07982318 42.8909248 10445 microspherule protein 1 "GO:0000123,GO:0002151,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005844,GO:0006281,GO:0006310,GO:0006464,GO:0008266,GO:0016032,GO:0016579,GO:0030425,GO:0031011,GO:0034046,GO:0043204,GO:0043981,GO:0043982,GO:0043984,GO:0044545,GO:0045944,GO:0071339,GO:1904751" histone acetyltransferase complex|G-quadruplex RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|polysome|DNA repair|DNA recombination|cellular protein modification process|poly(U) RNA binding|viral process|protein deubiquitination|dendrite|Ino80 complex|poly(G) binding|perikaryon|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex|positive regulation of transcription by RNA polymerase II|MLL1 complex|positive regulation of protein localization to nucleolus MCTP1 558.7768062 581.5697699 535.9838426 0.921615721 -0.117762769 0.770367278 1 3.72605404 3.581912341 79772 multiple C2 and transmembrane domain containing 1 "GO:0005509,GO:0005544,GO:0005789,GO:0016021,GO:0019722,GO:0030336,GO:0030672,GO:0045806,GO:0046928,GO:0048168,GO:0055037,GO:1902883" calcium ion binding|calcium-dependent phospholipid binding|endoplasmic reticulum membrane|integral component of membrane|calcium-mediated signaling|negative regulation of cell migration|synaptic vesicle membrane|negative regulation of endocytosis|regulation of neurotransmitter secretion|regulation of neuronal synaptic plasticity|recycling endosome|negative regulation of response to oxidative stress MCTS1 1107.359515 1139.795552 1074.923478 0.943084465 -0.084541107 0.809236807 1 5.923109355 5.826614314 28985 MCTS1 re-initiation and release factor "GO:0001731,GO:0002188,GO:0003743,GO:0005515,GO:0005829,GO:0005886,GO:0006974,GO:0007049,GO:0008284,GO:0022627,GO:0032790,GO:0040008,GO:0075522" formation of translation preinitiation complex|translation reinitiation|translation initiation factor activity|protein binding|cytosol|plasma membrane|cellular response to DNA damage stimulus|cell cycle|positive regulation of cell population proliferation|cytosolic small ribosomal subunit|ribosome disassembly|regulation of growth|IRES-dependent viral translational initiation MCU 1154.595546 1102.242182 1206.94891 1.094994304 0.130923365 0.705059415 1 15.45961729 17.65739076 90550 mitochondrial calcium uniporter "GO:0005262,GO:0005515,GO:0005739,GO:0005743,GO:0006851,GO:0015292,GO:0019722,GO:0031305,GO:0032024,GO:0034704,GO:0036444,GO:0042593,GO:0042802,GO:0051259,GO:0051560,GO:0051561,GO:0090023,GO:0090141,GO:0090527,GO:1990246" calcium channel activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|uniporter activity|calcium-mediated signaling|integral component of mitochondrial inner membrane|positive regulation of insulin secretion|calcium channel complex|calcium import into the mitochondrion|glucose homeostasis|identical protein binding|protein complex oligomerization|mitochondrial calcium ion homeostasis|positive regulation of mitochondrial calcium ion concentration|positive regulation of neutrophil chemotaxis|positive regulation of mitochondrial fission|actin filament reorganization|uniplex complex "hsa04020,hsa04218,hsa04621,hsa05010,hsa05012,hsa05014,hsa05017,hsa05020,hsa05022" Calcium signaling pathway|Cellular senescence|NOD-like receptor signaling pathway|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases MCUB 455.8275611 447.5955821 464.0595402 1.036783111 0.052114123 0.906057229 1 8.789894226 9.505774178 55013 mitochondrial calcium uniporter dominant negative subunit beta "GO:0005216,GO:0005654,GO:0005739,GO:0005743,GO:0006851,GO:0019855,GO:0031224,GO:0031305,GO:0034704,GO:0036444,GO:0043231,GO:0051560,GO:1990246" ion channel activity|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|calcium channel inhibitor activity|intrinsic component of membrane|integral component of mitochondrial inner membrane|calcium channel complex|calcium import into the mitochondrion|intracellular membrane-bounded organelle|mitochondrial calcium ion homeostasis|uniplex complex MCUR1 595.2464354 582.5847258 607.908145 1.043467359 0.061385471 0.879475639 1 5.390182888 5.866759683 63933 mitochondrial calcium uniporter regulator 1 "GO:0005515,GO:0005739,GO:0006851,GO:0031305,GO:0036444,GO:0051561,GO:0070509" protein binding|mitochondrion|mitochondrial calcium ion transmembrane transport|integral component of mitochondrial inner membrane|calcium import into the mitochondrion|positive regulation of mitochondrial calcium ion concentration|calcium ion import MDC1 1355.725574 1448.342167 1263.108982 0.872106751 -0.197423354 0.557464806 1 9.00373405 8.190458926 9656 mediator of DNA damage checkpoint 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005925,GO:0006303,GO:0008022,GO:0016604,GO:0031573,GO:0042802,GO:0070975" protein binding|nucleus|nucleoplasm|chromosome|focal adhesion|double-strand break repair via nonhomologous end joining|protein C-terminus binding|nuclear body|intra-S DNA damage checkpoint|identical protein binding|FHA domain binding MDFI 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.016793185 0.051012411 4188 MyoD family inhibitor "GO:0000122,GO:0005515,GO:0005634,GO:0005737,GO:0008134,GO:0009950,GO:0030178,GO:0042802,GO:0042994,GO:0043392,GO:0048704,GO:0060707,GO:0140416" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|cytoplasm|transcription factor binding|dorsal/ventral axis specification|negative regulation of Wnt signaling pathway|identical protein binding|cytoplasmic sequestering of transcription factor|negative regulation of DNA binding|embryonic skeletal system morphogenesis|trophoblast giant cell differentiation|transcription regulator inhibitor activity MDFIC 839.1736074 587.6595057 1090.687709 1.855985819 0.892185688 0.01472166 0.53522651 5.391826236 10.4382206 29969 MyoD family inhibitor domain containing "GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0007257,GO:0008134,GO:0016032,GO:0030111,GO:0030332,GO:0030957,GO:0042308,GO:0045892,GO:0045893,GO:0050434" "protein binding|nucleus|nucleolus|cytoplasm|activation of JUN kinase activity|transcription factor binding|viral process|regulation of Wnt signaling pathway|cyclin binding|Tat protein binding|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of viral transcription" MDGA1 24.49527683 24.35894324 24.63161041 1.011193719 0.016059408 1 1 0.118408153 0.124891217 266727 MAM domain containing glycosylphosphatidylinositol anchor 1 "GO:0001764,GO:0003674,GO:0005576,GO:0005615,GO:0005794,GO:0005886,GO:0007420,GO:0021527,GO:0046658,GO:0098982,GO:0099179,GO:1905606" neuron migration|molecular_function|extracellular region|extracellular space|Golgi apparatus|plasma membrane|brain development|spinal cord association neuron differentiation|anchored component of plasma membrane|GABA-ergic synapse|regulation of synaptic membrane adhesion|regulation of presynapse assembly MDH1 2459.303376 2464.313091 2454.293662 0.99593419 -0.005877681 0.98673876 1 81.30864136 84.46626208 4190 malate dehydrogenase 1 "GO:0004470,GO:0005515,GO:0005615,GO:0005813,GO:0005829,GO:0006094,GO:0006099,GO:0006107,GO:0006108,GO:0006734,GO:0030060,GO:0047860,GO:0070062" malic enzyme activity|protein binding|extracellular space|centrosome|cytosol|gluconeogenesis|tricarboxylic acid cycle|oxaloacetate metabolic process|malate metabolic process|NADH metabolic process|L-malate dehydrogenase activity|diiodophenylpyruvate reductase activity|extracellular exosome "hsa00020,hsa00270,hsa00620,hsa00630,hsa04964" Citrate cycle (TCA cycle)|Cysteine and methionine metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Proximal tubule bicarbonate reclamation MDH1B 29.15165334 39.58328277 18.72002391 0.472927524 -1.080308987 0.281482224 1 0.786177894 0.387821024 130752 malate dehydrogenase 1B "GO:0005975,GO:0006099,GO:0006107,GO:0006108,GO:0006734,GO:0030060" carbohydrate metabolic process|tricarboxylic acid cycle|oxaloacetate metabolic process|malate metabolic process|NADH metabolic process|L-malate dehydrogenase activity MDH2 4198.295079 4485.090424 3911.499734 0.872111678 -0.197415205 0.536265282 1 104.6792661 95.22449996 4191 malate dehydrogenase 2 "GO:0003723,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0006094,GO:0006099,GO:0006107,GO:0006108,GO:0006734,GO:0009060,GO:0016020,GO:0030060,GO:0043621,GO:0046554,GO:0070062" RNA binding|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|gluconeogenesis|tricarboxylic acid cycle|oxaloacetate metabolic process|malate metabolic process|NADH metabolic process|aerobic respiration|membrane|L-malate dehydrogenase activity|protein self-association|malate dehydrogenase (NADP+) activity|extracellular exosome "hsa00020,hsa00270,hsa00620,hsa00630" Citrate cycle (TCA cycle)|Cysteine and methionine metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism MDK 3988.028225 5434.074255 2541.982195 0.467785694 -1.096080355 0.000666211 0.071665278 170.9420439 83.40877787 4192 midkine "GO:0002232,GO:0002286,GO:0002690,GO:0005515,GO:0005576,GO:0007010,GO:0007162,GO:0007165,GO:0007219,GO:0007399,GO:0008083,GO:0008201,GO:0009611,GO:0010667,GO:0010718,GO:0010759,GO:0010838,GO:0010976,GO:0010996,GO:0030154,GO:0030279,GO:0030325,GO:0030335,GO:0032330,GO:0032735,GO:0035374,GO:0042246,GO:0043524,GO:0044849,GO:0045582,GO:0045590,GO:0045785,GO:0046850,GO:0048477,GO:0048714,GO:0050729,GO:0051781,GO:0061036,GO:0062023,GO:0071673,GO:0090023,GO:0090090,GO:0106015,GO:0106016,GO:0106091,GO:1900026,GO:1903039,GO:1904036,GO:1904399,GO:1904996,GO:1905555,GO:1905564,GO:1905653,GO:2000179,GO:2000249,GO:2000347,GO:2000391,GO:2001224" leukocyte chemotaxis involved in inflammatory response|T cell activation involved in immune response|positive regulation of leukocyte chemotaxis|protein binding|extracellular region|cytoskeleton organization|negative regulation of cell adhesion|signal transduction|Notch signaling pathway|nervous system development|growth factor activity|heparin binding|response to wounding|negative regulation of cardiac muscle cell apoptotic process|positive regulation of epithelial to mesenchymal transition|positive regulation of macrophage chemotaxis|positive regulation of keratinocyte proliferation|positive regulation of neuron projection development|response to auditory stimulus|cell differentiation|negative regulation of ossification|adrenal gland development|positive regulation of cell migration|regulation of chondrocyte differentiation|positive regulation of interleukin-12 production|chondroitin sulfate binding|tissue regeneration|negative regulation of neuron apoptotic process|estrous cycle|positive regulation of T cell differentiation|negative regulation of regulatory T cell differentiation|positive regulation of cell adhesion|regulation of bone remodeling|oogenesis|positive regulation of oligodendrocyte differentiation|positive regulation of inflammatory response|positive regulation of cell division|positive regulation of cartilage development|collagen-containing extracellular matrix|positive regulation of smooth muscle cell chemotaxis|positive regulation of neutrophil chemotaxis|negative regulation of canonical Wnt signaling pathway|negative regulation of inflammatory response to wounding|positive regulation of inflammatory response to wounding|glial cell projection elongation|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of leukocyte cell-cell adhesion|negative regulation of epithelial cell apoptotic process|heparan sulfate binding|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of blood vessel branching|positive regulation of vascular endothelial cell proliferation|positive regulation of artery morphogenesis|positive regulation of neural precursor cell proliferation|regulation of actin cytoskeleton reorganization|positive regulation of hepatocyte proliferation|positive regulation of neutrophil extravasation|positive regulation of neuron migration MDM1 226.6835608 207.0510175 246.3161041 1.18963967 0.250524661 0.632562126 1 1.512971232 1.877422584 56890 Mdm1 nuclear protein "GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0008017,GO:0045494,GO:0046600,GO:0060041" protein binding|nucleus|centrosome|centriole|cytosol|microtubule|microtubule binding|photoreceptor cell maintenance|negative regulation of centriole replication|retina development in camera-type eye MDM2 2258.939885 2237.97791 2279.90186 1.01873296 0.026775927 0.934729267 1 15.03856787 15.98022049 4193 MDM2 proto-oncogene "GO:0000122,GO:0000209,GO:0001228,GO:0002039,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006511,GO:0006915,GO:0006977,GO:0008097,GO:0008270,GO:0008284,GO:0016032,GO:0016567,GO:0016579,GO:0016604,GO:0016874,GO:0016925,GO:0018215,GO:0019789,GO:0019899,GO:0019904,GO:0030666,GO:0031625,GO:0031648,GO:0032436,GO:0032991,GO:0034504,GO:0036369,GO:0042176,GO:0042802,GO:0043021,GO:0043130,GO:0043161,GO:0043518,GO:0045184,GO:0045892,GO:0045931,GO:0045944,GO:0046677,GO:0047485,GO:0051603,GO:0051865,GO:0061630,GO:0061663,GO:0065003,GO:0071157,GO:0071456,GO:0071480,GO:0072717,GO:0097718,GO:1901796,GO:1901797,GO:1902254,GO:1990000" "negative regulation of transcription by RNA polymerase II|protein polyubiquitination|DNA-binding transcription activator activity, RNA polymerase II-specific|p53 binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|ubiquitin-dependent protein catabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|5S rRNA binding|zinc ion binding|positive regulation of cell population proliferation|viral process|protein ubiquitination|protein deubiquitination|nuclear body|ligase activity|protein sumoylation|protein phosphopantetheinylation|SUMO transferase activity|enzyme binding|protein domain specific binding|endocytic vesicle membrane|ubiquitin protein ligase binding|protein destabilization|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|protein localization to nucleus|transcription factor catabolic process|regulation of protein catabolic process|identical protein binding|ribonucleoprotein complex binding|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA damage response, signal transduction by p53 class mediator|establishment of protein localization|negative regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|response to antibiotic|protein N-terminus binding|proteolysis involved in cellular protein catabolic process|protein autoubiquitination|ubiquitin protein ligase activity|NEDD8 ligase activity|protein-containing complex assembly|negative regulation of cell cycle arrest|cellular response to hypoxia|cellular response to gamma radiation|cellular response to actinomycin D|disordered domain specific binding|regulation of signal transduction by p53 class mediator|negative regulation of signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|amyloid fibril formation" "hsa01522,hsa01524,hsa04068,hsa04110,hsa04115,hsa04120,hsa04144,hsa04151,hsa04218,hsa04625,hsa04919,hsa05131,hsa05163,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05205,hsa05206,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220" Endocrine resistance|Platinum drug resistance|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Ubiquitin mediated proteolysis|Endocytosis|PI3K-Akt signaling pathway|Cellular senescence|C-type lectin receptor signaling pathway|Thyroid hormone signaling pathway|Shigellosis|Human cytomegalovirus infection|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia MDM4 477.678806 493.2686006 462.0890114 0.936789836 -0.094202672 0.823956035 1 2.380855282 2.326435936 4194 MDM4 regulator of p53 "GO:0000122,GO:0001228,GO:0003170,GO:0003181,GO:0003203,GO:0003281,GO:0003283,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006977,GO:0008270,GO:0008285,GO:0016579,GO:0019899,GO:0030330,GO:0042177,GO:0043066,GO:0045944,GO:0050821,GO:0065003,GO:0071157,GO:0071456,GO:1901796" "negative regulation of transcription by RNA polymerase II|DNA-binding transcription activator activity, RNA polymerase II-specific|heart valve development|atrioventricular valve morphogenesis|endocardial cushion morphogenesis|ventricular septum development|atrial septum development|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|zinc ion binding|negative regulation of cell population proliferation|protein deubiquitination|enzyme binding|DNA damage response, signal transduction by p53 class mediator|negative regulation of protein catabolic process|negative regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|protein stabilization|protein-containing complex assembly|negative regulation of cell cycle arrest|cellular response to hypoxia|regulation of signal transduction by p53 class mediator" "hsa04115,hsa05206" p53 signaling pathway|MicroRNAs in cancer MDN1 1962.633117 2188.245068 1737.021166 0.79379645 -0.333158985 0.301984021 1 5.394873827 4.466901481 23195 midasin AAA ATPase 1 "GO:0000027,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0016020,GO:0016887,GO:0030687,GO:0045111,GO:0051082,GO:0065003" "ribosomal large subunit assembly|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytosol|rRNA processing|membrane|ATPase activity|preribosome, large subunit precursor|intermediate filament cytoskeleton|unfolded protein binding|protein-containing complex assembly" hsa03008 Ribosome biogenesis in eukaryotes MDP1 24.01749039 25.37389921 22.66108158 0.893086293 -0.163128515 0.916550668 1 1.666794398 1.552713703 145553 magnesium dependent phosphatase 1 "GO:0003993,GO:0004725,GO:0030389,GO:0035335,GO:0046872" acid phosphatase activity|protein tyrosine phosphatase activity|fructosamine metabolic process|peptidyl-tyrosine dephosphorylation|metal ion binding ME1 483.7212829 535.8967513 431.5458144 0.805277907 -0.312441341 0.449306448 1 8.065759264 6.774963656 4199 malic enzyme 1 "GO:0004470,GO:0004471,GO:0004473,GO:0005739,GO:0005829,GO:0005975,GO:0006090,GO:0006108,GO:0008948,GO:0009055,GO:0009165,GO:0009725,GO:0009743,GO:0019216,GO:0022900,GO:0030145,GO:0042802,GO:0043531,GO:0050661,GO:0051287,GO:1902031" malic enzyme activity|malate dehydrogenase (decarboxylating) (NAD+) activity|malate dehydrogenase (decarboxylating) (NADP+) activity|mitochondrion|cytosol|carbohydrate metabolic process|pyruvate metabolic process|malate metabolic process|oxaloacetate decarboxylase activity|electron transfer activity|nucleotide biosynthetic process|response to hormone|response to carbohydrate|regulation of lipid metabolic process|electron transport chain|manganese ion binding|identical protein binding|ADP binding|NADP binding|NAD binding|regulation of NADP metabolic process "hsa00620,hsa03320" Pyruvate metabolism|PPAR signaling pathway ME2 930.3615381 1062.658899 798.0641774 0.751006911 -0.41310191 0.247235195 1 5.959464555 4.668389725 4200 malic enzyme 2 "GO:0004470,GO:0004471,GO:0004473,GO:0005739,GO:0005759,GO:0006090,GO:0006099,GO:0006108,GO:0008948,GO:0009055,GO:0022900,GO:0043231,GO:0046872,GO:0051287,GO:1902031" malic enzyme activity|malate dehydrogenase (decarboxylating) (NAD+) activity|malate dehydrogenase (decarboxylating) (NADP+) activity|mitochondrion|mitochondrial matrix|pyruvate metabolic process|tricarboxylic acid cycle|malate metabolic process|oxaloacetate decarboxylase activity|electron transfer activity|electron transport chain|intracellular membrane-bounded organelle|metal ion binding|NAD binding|regulation of NADP metabolic process hsa00620 Pyruvate metabolism ME3 166.7039192 181.6771183 151.7307201 0.835166924 -0.259863518 0.655245103 1 3.482704438 3.03393195 10873 malic enzyme 3 "GO:0004470,GO:0004471,GO:0004473,GO:0005739,GO:0005759,GO:0006090,GO:0006099,GO:0006108,GO:0008948,GO:0009060,GO:0046872,GO:0051287,GO:0055114,GO:0070401,GO:0072592" malic enzyme activity|malate dehydrogenase (decarboxylating) (NAD+) activity|malate dehydrogenase (decarboxylating) (NADP+) activity|mitochondrion|mitochondrial matrix|pyruvate metabolic process|tricarboxylic acid cycle|malate metabolic process|oxaloacetate decarboxylase activity|aerobic respiration|metal ion binding|NAD binding|oxidation-reduction process|NADP+ binding|oxygen metabolic process "hsa00620,hsa03320" Pyruvate metabolism|PPAR signaling pathway MEA1 1323.33482 1220.99203 1425.677611 1.167638753 0.223593998 0.507715807 1 17.97643573 21.89414633 4201 male-enhanced antigen 1 "GO:0005515,GO:0007283,GO:0008584,GO:0030154" protein binding|spermatogenesis|male gonad development|cell differentiation MEAF6 670.527367 609.988537 731.0661971 1.198491697 0.261219915 0.494250126 1 6.528691354 8.161633658 64769 MYST/Esa1 associated factor 6 "GO:0000776,GO:0000777,GO:0005515,GO:0005654,GO:0005730,GO:0035267,GO:0043968,GO:0043972,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0043994,GO:0044154,GO:0070776,GO:1901796,GO:1990467,GO:1990468" kinetochore|condensed chromosome kinetochore|protein binding|nucleoplasm|nucleolus|NuA4 histone acetyltransferase complex|histone H2A acetylation|histone H3-K23 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|histone acetyltransferase activity (H3-K23 specific)|histone H3-K14 acetylation|MOZ/MORF histone acetyltransferase complex|regulation of signal transduction by p53 class mediator|NuA3a histone acetyltransferase complex|NuA3b histone acetyltransferase complex MEAK7 1082.545796 992.6269371 1172.464656 1.181173522 0.240220922 0.490254468 1 8.7325087 10.75891954 57707 "MTOR associated protein, eak-7 homolog" "GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005765,GO:0005829,GO:0016020,GO:0030334,GO:0031667,GO:0031929,GO:0032868,GO:0042127,GO:0043200,GO:0150032,GO:1903204" protein binding|nucleoplasm|nucleolus|cytoplasm|lysosomal membrane|cytosol|membrane|regulation of cell migration|response to nutrient levels|TOR signaling|response to insulin|regulation of cell population proliferation|response to amino acid|positive regulation of protein localization to lysosome|negative regulation of oxidative stress-induced neuron death MECOM 294.7477154 313.6213942 275.8740366 0.879640362 -0.185014292 0.701589668 1 2.209461292 2.027250777 2122 MDS1 and EVI1 complex locus "GO:0000118,GO:0000978,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006915,GO:0016607,GO:0030154,GO:0043069,GO:0045892,GO:0045893,GO:0045944,GO:0046329,GO:0046872,GO:0046974,GO:0051567,GO:0051726,GO:0070828,GO:0071425" "histone deacetylase complex|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|apoptotic process|nuclear speck|cell differentiation|negative regulation of programmed cell death|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|metal ion binding|histone methyltransferase activity (H3-K9 specific)|histone H3-K9 methylation|regulation of cell cycle|heterochromatin organization|hematopoietic stem cell proliferation" "hsa00310,hsa04010,hsa05200,hsa05220" Lysine degradation|MAPK signaling pathway|Pathways in cancer|Chronic myeloid leukemia zf-C2H2 MECP2 3207.215816 3110.840043 3303.591589 1.061961253 0.086731128 0.785740511 1 13.81196404 15.2995987 4204 methyl-CpG binding protein 2 "GO:0000122,GO:0000792,GO:0001662,GO:0001666,GO:0001964,GO:0001976,GO:0002087,GO:0003677,GO:0003682,GO:0003700,GO:0003714,GO:0003723,GO:0003729,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006020,GO:0006342,GO:0006349,GO:0006367,GO:0006541,GO:0006576,GO:0007052,GO:0007416,GO:0007585,GO:0007616,GO:0008104,GO:0008134,GO:0008211,GO:0008284,GO:0008327,GO:0008344,GO:0008542,GO:0009791,GO:0010385,GO:0010629,GO:0010971,GO:0016358,GO:0016525,GO:0016571,GO:0016573,GO:0019230,GO:0019233,GO:0019904,GO:0021549,GO:0021591,GO:0032048,GO:0035176,GO:0035197,GO:0042551,GO:0043524,GO:0043537,GO:0045892,GO:0045944,GO:0046470,GO:0047485,GO:0051151,GO:0051707,GO:0060079,GO:0060291,GO:0090063,GO:0098794,GO:1900114,GO:1905643,GO:1990841,GO:2000820" "negative regulation of transcription by RNA polymerase II|heterochromatin|behavioral fear response|response to hypoxia|startle response|nervous system process involved in regulation of systemic arterial blood pressure|regulation of respiratory gaseous exchange by nervous system process|DNA binding|chromatin binding|DNA-binding transcription factor activity|transcription corepressor activity|RNA binding|mRNA binding|protein binding|extracellular space|nucleus|nucleoplasm|centrosome|cytosol|inositol metabolic process|chromatin silencing|regulation of gene expression by genetic imprinting|transcription initiation from RNA polymerase II promoter|glutamine metabolic process|cellular biogenic amine metabolic process|mitotic spindle organization|synapse assembly|respiratory gaseous exchange by respiratory system|long-term memory|protein localization|transcription factor binding|glucocorticoid metabolic process|positive regulation of cell population proliferation|methyl-CpG binding|adult locomotory behavior|visual learning|post-embryonic development|double-stranded methylated DNA binding|negative regulation of gene expression|positive regulation of G2/M transition of mitotic cell cycle|dendrite development|negative regulation of angiogenesis|histone methylation|histone acetylation|proprioception|sensory perception of pain|protein domain specific binding|cerebellum development|ventricular system development|cardiolipin metabolic process|social behavior|siRNA binding|neuron maturation|negative regulation of neuron apoptotic process|negative regulation of blood vessel endothelial cell migration|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|phosphatidylcholine metabolic process|protein N-terminus binding|negative regulation of smooth muscle cell differentiation|response to other organism|excitatory postsynaptic potential|long-term synaptic potentiation|positive regulation of microtubule nucleation|postsynapse|positive regulation of histone H3-K9 trimethylation|positive regulation of DNA methylation|promoter-specific chromatin binding|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" MBD MECR 258.8773605 286.2175831 231.5371379 0.808954975 -0.305868687 0.539830988 1 4.709522699 3.9739022 51102 mitochondrial trans-2-enoyl-CoA reductase "GO:0005634,GO:0005739,GO:0005759,GO:0006631,GO:0006633,GO:0006635,GO:0019166" nucleus|mitochondrion|mitochondrial matrix|fatty acid metabolic process|fatty acid biosynthetic process|fatty acid beta-oxidation|trans-2-enoyl-CoA reductase (NADPH) activity "hsa00061,hsa00062" Fatty acid biosynthesis|Fatty acid elongation MED1 2729.562496 2855.071139 2604.053853 0.912080199 -0.132767409 0.677313051 1 17.7705888 16.90638579 5469 mediator complex subunit 1 "GO:0000122,GO:0000151,GO:0000785,GO:0000902,GO:0000978,GO:0001525,GO:0001889,GO:0001892,GO:0002088,GO:0002154,GO:0003222,GO:0003406,GO:0003682,GO:0003712,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0006367,GO:0006590,GO:0006606,GO:0006702,GO:0007420,GO:0007595,GO:0008134,GO:0010628,GO:0010839,GO:0016020,GO:0016567,GO:0016592,GO:0016922,GO:0019216,GO:0030216,GO:0030224,GO:0030331,GO:0030374,GO:0030518,GO:0031100,GO:0031490,GO:0032993,GO:0033148,GO:0035050,GO:0035116,GO:0035162,GO:0035257,GO:0035357,GO:0035729,GO:0035855,GO:0042789,GO:0042809,GO:0042974,GO:0042975,GO:0043066,GO:0044877,GO:0045444,GO:0045618,GO:0045648,GO:0045665,GO:0045893,GO:0045944,GO:0046966,GO:0048821,GO:0048822,GO:0050693,GO:0060261,GO:0060335,GO:0060744,GO:0060745,GO:0060750,GO:0061630,GO:0070318,GO:0070562,GO:0071364,GO:0071383,GO:0097067,GO:1990841,GO:2000347,GO:2001141" "negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|chromatin|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|angiogenesis|liver development|embryonic placenta development|lens development in camera-type eye|thyroid hormone mediated signaling pathway|ventricular trabecula myocardium morphogenesis|retinal pigment epithelium development|chromatin binding|transcription coregulator activity|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|thyroid hormone generation|protein import into nucleus|androgen biosynthetic process|brain development|lactation|transcription factor binding|positive regulation of gene expression|negative regulation of keratinocyte proliferation|membrane|protein ubiquitination|mediator complex|nuclear receptor binding|regulation of lipid metabolic process|keratinocyte differentiation|monocyte differentiation|estrogen receptor binding|nuclear receptor coactivator activity|intracellular steroid hormone receptor signaling pathway|animal organ regeneration|chromatin DNA binding|protein-DNA complex|positive regulation of intracellular estrogen receptor signaling pathway|embryonic heart tube development|embryonic hindlimb morphogenesis|embryonic hemopoiesis|nuclear hormone receptor binding|peroxisome proliferator activated receptor signaling pathway|cellular response to hepatocyte growth factor stimulus|megakaryocyte development|mRNA transcription by RNA polymerase II|vitamin D receptor binding|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|negative regulation of apoptotic process|protein-containing complex binding|fat cell differentiation|positive regulation of keratinocyte differentiation|positive regulation of erythrocyte differentiation|negative regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|erythrocyte development|enucleate erythrocyte development|LBD domain binding|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of interferon-gamma-mediated signaling pathway|mammary gland branching involved in thelarche|mammary gland branching involved in pregnancy|epithelial cell proliferation involved in mammary gland duct elongation|ubiquitin protein ligase activity|positive regulation of G0 to G1 transition|regulation of vitamin D receptor signaling pathway|cellular response to epidermal growth factor stimulus|cellular response to steroid hormone stimulus|cellular response to thyroid hormone stimulus|promoter-specific chromatin binding|positive regulation of hepatocyte proliferation|regulation of RNA biosynthetic process" "hsa01522,hsa04919" Endocrine resistance|Thyroid hormone signaling pathway other MED10 954.1132884 867.787353 1040.439224 1.198956427 0.261779228 0.461851341 1 39.91859042 49.92229326 84246 mediator complex subunit 10 "GO:0000151,GO:0003712,GO:0005515,GO:0005654,GO:0006367,GO:0016567,GO:0016592,GO:0045944,GO:0061630" ubiquitin ligase complex|transcription coregulator activity|protein binding|nucleoplasm|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|positive regulation of transcription by RNA polymerase II|ubiquitin protein ligase activity MED11 331.1107026 341.0252054 321.1961998 0.941854721 -0.08642355 0.856426268 1 18.23835648 17.91783566 400569 mediator complex subunit 11 "GO:0000151,GO:0003712,GO:0005515,GO:0006357,GO:0016567,GO:0016592,GO:0061630" ubiquitin ligase complex|transcription coregulator activity|protein binding|regulation of transcription by RNA polymerase II|protein ubiquitination|mediator complex|ubiquitin protein ligase activity MED12 2172.15719 1929.431296 2414.883085 1.251603563 0.323777671 0.312725662 1 14.11103083 18.42219866 9968 mediator complex subunit 12 "GO:0000151,GO:0000978,GO:0001843,GO:0003682,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0007492,GO:0007507,GO:0008013,GO:0008022,GO:0014003,GO:0014044,GO:0016020,GO:0016567,GO:0016592,GO:0019827,GO:0019904,GO:0021510,GO:0030374,GO:0036342,GO:0042809,GO:0045893,GO:0045944,GO:0046966,GO:0048702,GO:0060070,GO:0060071,GO:0060261,GO:0061630,GO:0090245,GO:1990403" "ubiquitin ligase complex|RNA polymerase II cis-regulatory region sequence-specific DNA binding|neural tube closure|chromatin binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|endoderm development|heart development|beta-catenin binding|protein C-terminus binding|oligodendrocyte development|Schwann cell development|membrane|protein ubiquitination|mediator complex|stem cell population maintenance|protein domain specific binding|spinal cord development|nuclear receptor coactivator activity|post-anal tail morphogenesis|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|embryonic neurocranium morphogenesis|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|positive regulation of transcription initiation from RNA polymerase II promoter|ubiquitin protein ligase activity|axis elongation involved in somitogenesis|embryonic brain development" hsa04919 Thyroid hormone signaling pathway other MED12L 86.08370543 92.36099312 79.80641774 0.864070589 -0.210778919 0.779563722 1 0.504286166 0.454508706 116931 mediator complex subunit 12L "GO:0003713,GO:0005515,GO:0006357,GO:0008013,GO:0008134,GO:0016592,GO:0045893" "transcription coactivator activity|protein binding|regulation of transcription by RNA polymerase II|beta-catenin binding|transcription factor binding|mediator complex|positive regulation of transcription, DNA-templated" hsa04919 Thyroid hormone signaling pathway MED13 3141.914213 3361.534167 2922.294259 0.869333499 -0.202018356 0.525538841 1 15.21174471 13.79371896 9969 mediator complex subunit 13 "GO:0003712,GO:0003713,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0016020,GO:0016592,GO:0030374,GO:0042809,GO:0045893,GO:0045944,GO:0046966,GO:0060261" "transcription coregulator activity|transcription coactivator activity|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter" hsa04919 Thyroid hormone signaling pathway MED13L 2317.916695 2295.8304 2340.002989 1.019240354 0.027494303 0.932835406 1 11.89278005 12.64375077 23389 mediator complex subunit 13L "GO:0003712,GO:0006357,GO:0016592" transcription coregulator activity|regulation of transcription by RNA polymerase II|mediator complex hsa04919 Thyroid hormone signaling pathway MED14 2809.671272 2808.383164 2810.95938 1.000917331 0.001322822 0.997967648 1 17.17810385 17.93450369 9282 mediator complex subunit 14 "GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0016020,GO:0016592,GO:0019827,GO:0030374,GO:0042809,GO:0045893,GO:0045944,GO:0060261,GO:0070847" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|stem cell population maintenance|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of transcription initiation from RNA polymerase II promoter|core mediator complex" hsa04919 Thyroid hormone signaling pathway MED15 1973.992112 2021.792289 1926.191934 0.952715046 -0.069883321 0.829727269 1 18.29818567 18.18389788 51586 mediator complex subunit 15 "GO:0003712,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0006367,GO:0016020,GO:0016592" transcription coregulator activity|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex MED16 888.3232591 883.0116925 893.6348258 1.012030569 0.017252869 0.965180096 1 15.45315382 16.31273151 10025 mediator complex subunit 16 "GO:0003713,GO:0003824,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0006367,GO:0016020,GO:0016592,GO:0042809,GO:0045893,GO:0046966,GO:0060261" "transcription coactivator activity|catalytic activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter" hsa04919 Thyroid hormone signaling pathway MED17 818.0631675 794.7105232 841.4158117 1.05877019 0.082389481 0.824527698 1 7.91218487 8.738040654 9440 mediator complex subunit 17 "GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0016020,GO:0016592,GO:0030374,GO:0042809,GO:0045893,GO:0045944,GO:0046966,GO:0060261,GO:0070847" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter|core mediator complex" hsa04919 Thyroid hormone signaling pathway MED18 260.3728245 253.7389921 267.0066569 1.052288632 0.073530475 0.889296581 1 6.879542191 7.551102176 54797 mediator complex subunit 18 "GO:0000151,GO:0003712,GO:0005515,GO:0006357,GO:0006369,GO:0016567,GO:0016592,GO:0061630,GO:0070847" ubiquitin ligase complex|transcription coregulator activity|protein binding|regulation of transcription by RNA polymerase II|termination of RNA polymerase II transcription|protein ubiquitination|mediator complex|ubiquitin protein ligase activity|core mediator complex MED19 334.3782571 362.3392807 306.4172335 0.845663857 -0.241843775 0.599679609 1 11.97078037 10.55932512 219541 mediator complex subunit 19 "GO:0003712,GO:0005515,GO:0008134,GO:0016592,GO:0045944" transcription coregulator activity|protein binding|transcription factor binding|mediator complex|positive regulation of transcription by RNA polymerase II MED20 416.4790892 418.161859 414.7963194 0.991951586 -0.011658385 0.984607225 1 7.734997433 8.003253623 9477 mediator complex subunit 20 "GO:0000151,GO:0003713,GO:0003899,GO:0005515,GO:0005654,GO:0006351,GO:0006357,GO:0006366,GO:0006367,GO:0016567,GO:0016592,GO:0045893,GO:0061630" "ubiquitin ligase complex|transcription coactivator activity|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|positive regulation of transcription, DNA-templated|ubiquitin protein ligase activity" MED21 865.9754227 702.3495301 1029.601315 1.46593864 0.551824718 0.127451116 1 13.32766053 20.37913023 9412 mediator complex subunit 21 "GO:0003712,GO:0003713,GO:0003899,GO:0005515,GO:0006357,GO:0016592,GO:0032774,GO:0045944" transcription coregulator activity|transcription coactivator activity|DNA-directed 5'-3' RNA polymerase activity|protein binding|regulation of transcription by RNA polymerase II|mediator complex|RNA biosynthetic process|positive regulation of transcription by RNA polymerase II MED22 1546.200049 1571.151839 1521.248259 0.968237583 -0.046567 0.889709198 1 12.29121068 12.41345084 6837 mediator complex subunit 22 "GO:0003712,GO:0005515,GO:0005737,GO:0006357,GO:0016592" transcription coregulator activity|protein binding|cytoplasm|regulation of transcription by RNA polymerase II|mediator complex MED23 736.3889036 633.3325243 839.4452829 1.325441614 0.40647312 0.276879707 1 5.624418392 7.775962384 9439 mediator complex subunit 23 "GO:0003713,GO:0005515,GO:0005654,GO:0005667,GO:0006355,GO:0006357,GO:0006367,GO:0010628,GO:0016592,GO:0045893" "transcription coactivator activity|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|positive regulation of gene expression|mediator complex|positive regulation of transcription, DNA-templated" MED24 1849.704543 1776.172945 1923.236141 1.082797791 0.11476385 0.724353576 1 25.27589033 28.54760988 9862 mediator complex subunit 24 "GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006367,GO:0016592,GO:0030374,GO:0042809,GO:0045893,GO:0046966,GO:0060261" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|mediator complex|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter" hsa04919 Thyroid hormone signaling pathway MED25 1133.930725 969.2829498 1298.578501 1.339731088 0.421943451 0.221622124 1 11.86627072 16.58241643 81857 mediator complex subunit 25 "GO:0000122,GO:0001223,GO:0005515,GO:0005654,GO:0005667,GO:0006367,GO:0008134,GO:0016592,GO:0035563,GO:0042974,GO:0045944,GO:0046965,GO:0048147,GO:0071158,GO:2001178" negative regulation of transcription by RNA polymerase II|transcription coactivator binding|protein binding|nucleoplasm|transcription regulator complex|transcription initiation from RNA polymerase II promoter|transcription factor binding|mediator complex|positive regulation of chromatin binding|retinoic acid receptor binding|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|negative regulation of fibroblast proliferation|positive regulation of cell cycle arrest|positive regulation of mediator complex assembly MED26 195.6774233 209.0809295 182.2739171 0.87178643 -0.197953348 0.721481744 1 3.338339056 3.035683413 9441 mediator complex subunit 26 "GO:0003712,GO:0003713,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0010628,GO:0016592,GO:0045893,GO:0070847" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|positive regulation of gene expression|mediator complex|positive regulation of transcription, DNA-templated|core mediator complex" MED27 690.568665 700.3196182 680.8177118 0.972152849 -0.040744933 0.918179634 1 5.876195839 5.958634463 9442 mediator complex subunit 27 "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0006357,GO:0006367,GO:0016592,GO:0045893" "transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|mediator complex|positive regulation of transcription, DNA-templated" hsa04919 Thyroid hormone signaling pathway MED28 840.7242491 794.7105232 886.7379749 1.115799966 0.158078413 0.66561877 1 3.706878286 4.314302573 80306 mediator complex subunit 28 "GO:0003779,GO:0005515,GO:0005654,GO:0016020,GO:0016592,GO:0019827,GO:0030864,GO:0051151" actin binding|protein binding|nucleoplasm|membrane|mediator complex|stem cell population maintenance|cortical actin cytoskeleton|negative regulation of smooth muscle cell differentiation MED29 984.9897734 991.6119811 978.3675656 0.98664355 -0.019399126 0.959305461 1 13.98931717 14.39702397 55588 mediator complex subunit 29 "GO:0003712,GO:0005515,GO:0005654,GO:0006357,GO:0008134,GO:0016592" transcription coregulator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|mediator complex MED30 497.3571244 457.7451417 536.969107 1.173074399 0.230294515 0.575462783 1 7.142075355 8.739084017 90390 mediator complex subunit 30 "GO:0000151,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006367,GO:0016567,GO:0016592,GO:0019827,GO:0030374,GO:0042809,GO:0045893,GO:0046966,GO:0060261,GO:0061630" "ubiquitin ligase complex|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|stem cell population maintenance|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter|ubiquitin protein ligase activity" hsa04919 Thyroid hormone signaling pathway MED31 167.2586562 152.2433953 182.2739171 1.197253364 0.259728489 0.655110489 1 4.733327739 5.911103613 51003 mediator complex subunit 31 "GO:0000151,GO:0003712,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0016567,GO:0016592,GO:0048147,GO:0060173,GO:0061630,GO:0070847" ubiquitin ligase complex|transcription coregulator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|negative regulation of fibroblast proliferation|limb development|ubiquitin protein ligase activity|core mediator complex MED4 568.7833514 524.7322356 612.8344671 1.167899407 0.223916019 0.57338624 1 7.528565607 9.171357174 29079 mediator complex subunit 4 "GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0006367,GO:0016020,GO:0016592,GO:0030374,GO:0042809,GO:0045893,GO:0046966,GO:0060261,GO:0070847" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter|core mediator complex" hsa04919 Thyroid hormone signaling pathway MED6 566.0799363 541.9864871 590.1733855 1.088907933 0.12288198 0.759714852 1 11.57238767 13.14407612 10001 mediator complex subunit 6 "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0008134,GO:0016020,GO:0016592,GO:0045944,GO:0070847" transcription coactivator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|membrane|mediator complex|positive regulation of transcription by RNA polymerase II|core mediator complex MED7 211.0677879 217.2005772 204.9349986 0.943528794 -0.08386155 0.882647029 1 4.497319296 4.42613657 9443 mediator complex subunit 7 "GO:0000151,GO:0003713,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0016567,GO:0016592,GO:0016604,GO:0019827,GO:0045893,GO:0061630" "ubiquitin ligase complex|transcription coactivator activity|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|nuclear body|stem cell population maintenance|positive regulation of transcription, DNA-templated|ubiquitin protein ligase activity" MED8 884.0110571 857.6377933 910.3843209 1.061502103 0.086107229 0.813639458 1 21.59936781 23.91540988 112950 mediator complex subunit 8 "GO:0000978,GO:0003712,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0016567,GO:0016592,GO:0070847" RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription coregulator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|core mediator complex MED9 384.2380306 369.4439725 399.0320887 1.080088236 0.111149176 0.804747031 1 8.470363914 9.542831055 55090 mediator complex subunit 9 "GO:0003712,GO:0005515,GO:0006357,GO:0016592" transcription coregulator activity|protein binding|regulation of transcription by RNA polymerase II|mediator complex MEF2A 1849.20523 1674.677348 2023.733112 1.208431651 0.273135876 0.399766704 1 6.392561031 8.057733589 4205 myocyte enhancer factor 2A "GO:0000002,GO:0000122,GO:0000165,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001085,GO:0001228,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006351,GO:0006357,GO:0006915,GO:0007507,GO:0007517,GO:0010613,GO:0019901,GO:0030154,GO:0033613,GO:0035035,GO:0042826,GO:0043565,GO:0045944,GO:0046326,GO:0046332,GO:0046982,GO:0048311,GO:0048813,GO:0051149,GO:0055005,GO:0061337,GO:0070375,GO:0071277" "mitochondrial genome maintenance|negative regulation of transcription by RNA polymerase II|MAPK cascade|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|transcription, DNA-templated|regulation of transcription by RNA polymerase II|apoptotic process|heart development|muscle organ development|positive regulation of cardiac muscle hypertrophy|protein kinase binding|cell differentiation|activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|SMAD binding|protein heterodimerization activity|mitochondrion distribution|dendrite morphogenesis|positive regulation of muscle cell differentiation|ventricular cardiac myofibril assembly|cardiac conduction|ERK5 cascade|cellular response to calcium ion" "hsa04022,hsa04371,hsa04928,hsa05418" "cGMP-PKG signaling pathway|Apelin signaling pathway|Parathyroid hormone synthesis, secretion and action|Fluid shear stress and atherosclerosis" SRF MEF2C 14.4941749 14.20938356 14.77896625 1.040084968 0.056701392 1 1 0.081252698 0.088150046 4208 myocyte enhancer factor 2C "GO:0000122,GO:0000165,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001568,GO:0001649,GO:0001764,GO:0001782,GO:0001947,GO:0001958,GO:0001974,GO:0002062,GO:0002467,GO:0002634,GO:0003138,GO:0003139,GO:0003151,GO:0003185,GO:0003211,GO:0003680,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0006915,GO:0006959,GO:0007399,GO:0007507,GO:0007517,GO:0007519,GO:0007521,GO:0007611,GO:0010628,GO:0010629,GO:0010694,GO:0014033,GO:0014902,GO:0016528,GO:0016607,GO:0030154,GO:0030182,GO:0030220,GO:0030279,GO:0030318,GO:0030501,GO:0030890,GO:0032991,GO:0033613,GO:0035690,GO:0035984,GO:0042100,GO:0042826,GO:0043231,GO:0043523,GO:0043524,GO:0043537,GO:0045652,GO:0045663,GO:0045666,GO:0045669,GO:0045893,GO:0045944,GO:0046928,GO:0046982,GO:0048167,GO:0048643,GO:0048666,GO:0048667,GO:0050853,GO:0051145,GO:0051149,GO:0051963,GO:0051966,GO:0055012,GO:0060025,GO:0060045,GO:0060079,GO:0060998,GO:0061333,GO:0071222,GO:0071277,GO:0071374,GO:0071498,GO:0071560,GO:0072102,GO:0072160,GO:0098794,GO:1904706,GO:1904753,GO:1905563,GO:1990837,GO:2000111,GO:2000310,GO:2000311,GO:2000727,GO:2000987,GO:2001013,GO:2001016" "negative regulation of transcription by RNA polymerase II|MAPK cascade|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blood vessel development|osteoblast differentiation|neuron migration|B cell homeostasis|heart looping|endochondral ossification|blood vessel remodeling|chondrocyte differentiation|germinal center formation|regulation of germinal center formation|primary heart field specification|secondary heart field specification|outflow tract morphogenesis|sinoatrial valve morphogenesis|cardiac ventricle formation|minor groove of adenine-thymine-rich DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|apoptotic process|humoral immune response|nervous system development|heart development|muscle organ development|skeletal muscle tissue development|muscle cell fate determination|learning or memory|positive regulation of gene expression|negative regulation of gene expression|positive regulation of alkaline phosphatase activity|neural crest cell differentiation|myotube differentiation|sarcoplasm|nuclear speck|cell differentiation|neuron differentiation|platelet formation|negative regulation of ossification|melanocyte differentiation|positive regulation of bone mineralization|positive regulation of B cell proliferation|protein-containing complex|activating transcription factor binding|cellular response to drug|cellular response to trichostatin A|B cell proliferation|histone deacetylase binding|intracellular membrane-bounded organelle|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|negative regulation of blood vessel endothelial cell migration|regulation of megakaryocyte differentiation|positive regulation of myoblast differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of neurotransmitter secretion|protein heterodimerization activity|regulation of synaptic plasticity|positive regulation of skeletal muscle tissue development|neuron development|cell morphogenesis involved in neuron differentiation|B cell receptor signaling pathway|smooth muscle cell differentiation|positive regulation of muscle cell differentiation|regulation of synapse assembly|regulation of synaptic transmission, glutamatergic|ventricular cardiac muscle cell differentiation|regulation of synaptic activity|positive regulation of cardiac muscle cell proliferation|excitatory postsynaptic potential|regulation of dendritic spine development|renal tubule morphogenesis|cellular response to lipopolysaccharide|cellular response to calcium ion|cellular response to parathyroid hormone stimulus|cellular response to fluid shear stress|cellular response to transforming growth factor beta stimulus|glomerulus morphogenesis|nephron tubule epithelial cell differentiation|postsynapse|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of vascular associated smooth muscle cell migration|negative regulation of vascular endothelial cell proliferation|sequence-specific double-stranded DNA binding|positive regulation of macrophage apoptotic process|regulation of NMDA receptor activity|regulation of AMPA receptor activity|positive regulation of cardiac muscle cell differentiation|positive regulation of behavioral fear response|epithelial cell proliferation involved in renal tubule morphogenesis|positive regulation of skeletal muscle cell differentiation" "hsa04010,hsa04022,hsa04371,hsa04921,hsa04928,hsa05202,hsa05418" "MAPK signaling pathway|cGMP-PKG signaling pathway|Apelin signaling pathway|Oxytocin signaling pathway|Parathyroid hormone synthesis, secretion and action|Transcriptional misregulation in cancer|Fluid shear stress and atherosclerosis" SRF MEF2D 1441.463868 1382.370029 1500.557706 1.085496412 0.118354957 0.723699992 1 9.809747129 11.10713715 4209 myocyte enhancer factor 2D "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001649,GO:0001958,GO:0002062,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006915,GO:0007399,GO:0007512,GO:0007517,GO:0030154,GO:0033613,GO:0035914,GO:0042803,GO:0042826,GO:0043231,GO:0045944,GO:0046982,GO:1904707,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|osteoblast differentiation|endochondral ossification|chondrocyte differentiation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|apoptotic process|nervous system development|adult heart development|muscle organ development|cell differentiation|activating transcription factor binding|skeletal muscle cell differentiation|protein homodimerization activity|histone deacetylase binding|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of vascular associated smooth muscle cell proliferation|sequence-specific double-stranded DNA binding" "hsa04022,hsa04371,hsa04928" "cGMP-PKG signaling pathway|Apelin signaling pathway|Parathyroid hormone synthesis, secretion and action" MEFV 7.104691779 14.20938356 0 0 #NAME? 0.012847493 0.502037376 0.197761789 0 4210 "MEFV innate immuity regulator, pyrin" "GO:0001726,GO:0003779,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005776,GO:0005829,GO:0005874,GO:0005875,GO:0006954,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0030027,GO:0031410,GO:0032691,GO:0032695,GO:0034341,GO:0042802,GO:0045087,GO:0050728,GO:0061630,GO:0071641,GO:1900016,GO:1900226,GO:2001056" ruffle|actin binding|protein binding|nucleus|nucleoplasm|cytoplasm|autophagosome|cytosol|microtubule|microtubule associated complex|inflammatory response|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|lamellipodium|cytoplasmic vesicle|negative regulation of interleukin-1 beta production|negative regulation of interleukin-12 production|response to interferon-gamma|identical protein binding|innate immune response|negative regulation of inflammatory response|ubiquitin protein ligase activity|negative regulation of macrophage inflammatory protein 1 alpha production|negative regulation of cytokine production involved in inflammatory response|negative regulation of NLRP3 inflammasome complex assembly|positive regulation of cysteine-type endopeptidase activity "hsa04621,hsa05135" NOD-like receptor signaling pathway|Yersinia infection MEGF6 67.84418955 57.8524902 77.83588891 1.345419854 0.428056453 0.586324283 1 0.338144782 0.474543962 1953 multiple EGF like domains 6 "GO:0005509,GO:0005515,GO:0005575,GO:0005576,GO:0008150" calcium ion binding|protein binding|cellular_component|extracellular region|biological_process MEGF8 2007.504464 2224.783483 1790.225445 0.804674009 -0.31352366 0.330587882 1 10.1173956 8.49189539 1954 multiple EGF like domains 8 "GO:0003143,GO:0005509,GO:0005515,GO:0005634,GO:0009887,GO:0009888,GO:0010468,GO:0016021,GO:0030326,GO:0030509,GO:0035108,GO:0042074,GO:0045879,GO:0048704,GO:0048842,GO:0055113,GO:0060971,GO:0060972,GO:0060976,GO:0061371,GO:0070062,GO:0071907,GO:0097094,GO:0097155" embryonic heart tube morphogenesis|calcium ion binding|protein binding|nucleus|animal organ morphogenesis|tissue development|regulation of gene expression|integral component of membrane|embryonic limb morphogenesis|BMP signaling pathway|limb morphogenesis|cell migration involved in gastrulation|negative regulation of smoothened signaling pathway|embryonic skeletal system morphogenesis|positive regulation of axon extension involved in axon guidance|epiboly involved in gastrulation with mouth forming second|embryonic heart tube left/right pattern formation|left/right pattern formation|coronary vasculature development|determination of heart left/right asymmetry|extracellular exosome|determination of digestive tract left/right asymmetry|craniofacial suture morphogenesis|fasciculation of sensory neuron axon hsa04340 Hedgehog signaling pathway MEGF9 1133.71472 1055.554207 1211.875232 1.148093792 0.199240506 0.564579698 1 8.485729654 10.1620772 1955 multiple EGF like domains 9 "GO:0005575,GO:0005604,GO:0008150,GO:0009887,GO:0009888,GO:0016021,GO:0016477,GO:0034446" cellular_component|basement membrane|biological_process|animal organ morphogenesis|tissue development|integral component of membrane|cell migration|substrate adhesion-dependent cell spreading MEI1 15.5536682 19.2841634 11.823173 0.613102718 -0.705799294 0.580381262 1 0.208914406 0.133603415 150365 meiotic double-stranded break formation protein 1 GO:0007127 meiosis I MEIS1 66.55928801 71.04691779 62.07165824 0.873671373 -0.194837375 0.817338422 1 0.788058639 0.718162246 4211 Meis homeobox 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0001654,GO:0002089,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007420,GO:0007626,GO:0008284,GO:0009880,GO:0009887,GO:0030097,GO:0035855,GO:0045638,GO:0045665,GO:0045944,GO:0060044,GO:0060216" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|eye development|lens morphogenesis in camera-type eye|DNA binding|chromatin binding|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|brain development|locomotory behavior|positive regulation of cell population proliferation|embryonic pattern specification|animal organ morphogenesis|hemopoiesis|megakaryocyte development|negative regulation of myeloid cell differentiation|negative regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of cardiac muscle cell proliferation|definitive hemopoiesis" "hsa04550,hsa05202" Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer Homeobox MEIS2 346.5901419 355.2345889 337.9456949 0.951331051 -0.071980627 0.879535081 1 3.267595121 3.242469061 4212 Meis homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0008134,GO:0008284,GO:0008542,GO:0009612,GO:0009880,GO:0009887,GO:0031016,GO:0045638,GO:0045931,GO:0045944,GO:0048471,GO:0070848,GO:0110024,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|transcription factor binding|positive regulation of cell population proliferation|visual learning|response to mechanical stimulus|embryonic pattern specification|animal organ morphogenesis|pancreas development|negative regulation of myeloid cell differentiation|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|response to growth factor|positive regulation of cardiac muscle myoblast proliferation|sequence-specific double-stranded DNA binding" Homeobox MEIS3 506.7968084 395.8328277 617.7607892 1.56066083 0.642157038 0.115238746 1 7.119153518 11.58918293 56917 Meis homeobox 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0005634,GO:0006357,GO:0007420,GO:0008284,GO:0009880,GO:0009887,GO:0043565,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|nucleus|regulation of transcription by RNA polymerase II|brain development|positive regulation of cell population proliferation|embryonic pattern specification|animal organ morphogenesis|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" MELK 2420.272355 2018.747421 2821.797289 1.397796108 0.483153935 0.130643458 1 37.60295519 54.82539053 9833 maternal embryonic leucine zipper kinase "GO:0000086,GO:0004674,GO:0004715,GO:0005509,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0005938,GO:0006468,GO:0006915,GO:0008283,GO:0008289,GO:0008631,GO:0016020,GO:0018108,GO:0030097,GO:0035556,GO:0043065,GO:0046777,GO:0061351,GO:0106310,GO:0106311" G2/M transition of mitotic cell cycle|protein serine/threonine kinase activity|non-membrane spanning protein tyrosine kinase activity|calcium ion binding|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|cell cortex|protein phosphorylation|apoptotic process|cell population proliferation|lipid binding|intrinsic apoptotic signaling pathway in response to oxidative stress|membrane|peptidyl-tyrosine phosphorylation|hemopoiesis|intracellular signal transduction|positive regulation of apoptotic process|protein autophosphorylation|neural precursor cell proliferation|protein serine kinase activity|protein threonine kinase activity MELTF 2162.564843 2216.663835 2108.465851 0.951188817 -0.072196341 0.823008807 1 22.06056265 21.88765579 4241 melanotransferrin "GO:0001558,GO:0005506,GO:0005515,GO:0005576,GO:0005615,GO:0005769,GO:0005788,GO:0005886,GO:0006826,GO:0009986,GO:0010756,GO:0042127,GO:0043687,GO:0044267,GO:0046658,GO:0055037,GO:0055072,GO:0070062,GO:0090091,GO:1900025" regulation of cell growth|iron ion binding|protein binding|extracellular region|extracellular space|early endosome|endoplasmic reticulum lumen|plasma membrane|iron ion transport|cell surface|positive regulation of plasminogen activation|regulation of cell population proliferation|post-translational protein modification|cellular protein metabolic process|anchored component of plasma membrane|recycling endosome|iron ion homeostasis|extracellular exosome|positive regulation of extracellular matrix disassembly|negative regulation of substrate adhesion-dependent cell spreading MEMO1 321.0677849 294.3372308 347.798339 1.181632164 0.240781002 0.606043166 1 4.671620928 5.757922685 51072 mediator of cell motility 1 "GO:0005515,GO:0005634,GO:0005829,GO:0032886,GO:2000145" protein binding|nucleus|cytosol|regulation of microtubule-based process|regulation of cell motility MEN1 1640.983871 1517.359173 1764.60857 1.162947179 0.217785572 0.507216322 1 20.4005546 24.74673419 4221 menin 1 "GO:0000122,GO:0000165,GO:0000400,GO:0000403,GO:0000781,GO:0000785,GO:0000976,GO:0001933,GO:0002076,GO:0003682,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005788,GO:0005829,GO:0006281,GO:0006357,GO:0006974,GO:0008285,GO:0009411,GO:0010332,GO:0016363,GO:0018024,GO:0030511,GO:0030674,GO:0032092,GO:0032154,GO:0032991,GO:0034968,GO:0035097,GO:0043433,GO:0043687,GO:0044267,GO:0045668,GO:0045736,GO:0045786,GO:0045892,GO:0045944,GO:0046329,GO:0047485,GO:0051974,GO:0070412,GO:1904837" "negative regulation of transcription by RNA polymerase II|MAPK cascade|four-way junction DNA binding|Y-form DNA binding|chromosome, telomeric region|chromatin|transcription regulatory region sequence-specific DNA binding|negative regulation of protein phosphorylation|osteoblast development|chromatin binding|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum lumen|cytosol|DNA repair|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|negative regulation of cell population proliferation|response to UV|response to gamma radiation|nuclear matrix|histone-lysine N-methyltransferase activity|positive regulation of transforming growth factor beta receptor signaling pathway|protein-macromolecule adaptor activity|positive regulation of protein binding|cleavage furrow|protein-containing complex|histone lysine methylation|histone methyltransferase complex|negative regulation of DNA-binding transcription factor activity|post-translational protein modification|cellular protein metabolic process|negative regulation of osteoblast differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|protein N-terminus binding|negative regulation of telomerase activity|R-SMAD binding|beta-catenin-TCF complex assembly" "hsa04934,hsa05202" Cushing syndrome|Transcriptional misregulation in cancer MEOX1 46.27229282 64.95718198 27.58740366 0.424701362 -1.235479359 0.157344677 1 1.200675953 0.531894374 4222 mesenchyme homeobox 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001757,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0007275,GO:0008150,GO:0043565,GO:0045944,GO:0060218,GO:0061053,GO:0061056,GO:0071837,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|somite specification|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|biological_process|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|hematopoietic stem cell differentiation|somite development|sclerotome development|HMG box domain binding|sequence-specific double-stranded DNA binding" MEPCE 1505.017382 1517.359173 1492.675591 0.983732539 -0.023661972 0.945171645 1 25.5736736 26.2413446 56257 methylphosphate capping enzyme "GO:0000122,GO:0001510,GO:0003723,GO:0005515,GO:0005634,GO:0008171,GO:0008173,GO:0008757,GO:0016073,GO:0017069,GO:0035562,GO:0040031,GO:0097322,GO:0120259,GO:1900087,GO:1904871,GO:1905382,GO:1990276,GO:1990904" negative regulation of transcription by RNA polymerase II|RNA methylation|RNA binding|protein binding|nucleus|O-methyltransferase activity|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|snRNA metabolic process|snRNA binding|negative regulation of chromatin binding|snRNA modification|7SK snRNA binding|7SK snRNP|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of protein localization to Cajal body|positive regulation of snRNA transcription by RNA polymerase II|RNA 5'-methyltransferase activity|ribonucleoprotein complex MERTK 188.3648906 180.6621624 196.0676189 1.085272181 0.118056908 0.838299401 1 2.391505799 2.707235514 10461 "MER proto-oncogene, tyrosine kinase" "GO:0001750,GO:0001779,GO:0001818,GO:0004714,GO:0005515,GO:0005524,GO:0005615,GO:0005737,GO:0005886,GO:0005887,GO:0006468,GO:0006909,GO:0007166,GO:0007169,GO:0007267,GO:0007275,GO:0007283,GO:0007399,GO:0016028,GO:0016477,GO:0018108,GO:0030168,GO:0032940,GO:0033674,GO:0034446,GO:0043235,GO:0043491,GO:0050766,GO:0050900,GO:0051250,GO:0060041,GO:0060068,GO:0097350,GO:2000107" photoreceptor outer segment|natural killer cell differentiation|negative regulation of cytokine production|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|extracellular space|cytoplasm|plasma membrane|integral component of plasma membrane|protein phosphorylation|phagocytosis|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|cell-cell signaling|multicellular organism development|spermatogenesis|nervous system development|rhabdomere|cell migration|peptidyl-tyrosine phosphorylation|platelet activation|secretion by cell|positive regulation of kinase activity|substrate adhesion-dependent cell spreading|receptor complex|protein kinase B signaling|positive regulation of phagocytosis|leukocyte migration|negative regulation of lymphocyte activation|retina development in camera-type eye|vagina development|neutrophil clearance|negative regulation of leukocyte apoptotic process MESD 2081.605898 2070.510175 2092.701621 1.010717863 0.015380333 0.963443384 1 24.96762763 26.3222585 23184 mesoderm development LRP chaperone "GO:0001503,GO:0003674,GO:0005515,GO:0005783,GO:0005886,GO:0006457,GO:0006909,GO:0007498,GO:0016055,GO:0034394,GO:0042802,GO:0050750,GO:1904395" ossification|molecular_function|protein binding|endoplasmic reticulum|plasma membrane|protein folding|phagocytosis|mesoderm development|Wnt signaling pathway|protein localization to cell surface|identical protein binding|low-density lipoprotein particle receptor binding|positive regulation of skeletal muscle acetylcholine-gated channel clustering MESP1 42.00462808 42.62815067 41.38110549 0.970745971 -0.042834281 0.99205358 1 1.857973708 1.881313146 55897 mesoderm posterior bHLH transcription factor 1 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001707,GO:0001947,GO:0003007,GO:0003139,GO:0003143,GO:0003210,GO:0003211,GO:0003236,GO:0003241,GO:0003259,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007219,GO:0007369,GO:0008078,GO:0010467,GO:0022008,GO:0023019,GO:0032525,GO:0035481,GO:0042662,GO:0042664,GO:0045446,GO:0045747,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0048368,GO:0051155,GO:0055007,GO:0060913,GO:0060921,GO:0060947,GO:0060975,GO:0070368,GO:0090082" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|mesoderm formation|heart looping|heart morphogenesis|secondary heart field specification|embryonic heart tube morphogenesis|cardiac atrium formation|cardiac ventricle formation|sinus venosus morphogenesis|growth involved in heart morphogenesis|cardioblast anterior-lateral migration|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|Notch signaling pathway|gastrulation|mesodermal cell migration|gene expression|neurogenesis|signal transduction involved in regulation of gene expression|somite rostral/caudal axis specification|positive regulation of Notch signaling pathway involved in heart induction|negative regulation of mesodermal cell fate specification|negative regulation of endodermal cell fate specification|endothelial cell differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|lateral mesoderm development|positive regulation of striated muscle cell differentiation|cardiac muscle cell differentiation|cardiac cell fate determination|sinoatrial node cell differentiation|cardiac vascular smooth muscle cell differentiation|cardioblast migration to the midline involved in heart field formation|positive regulation of hepatocyte differentiation|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway" MESP2 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.094031596 0.0634752 145873 mesoderm posterior bHLH transcription factor 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001707,GO:0003007,GO:0005634,GO:0006357,GO:0007219,GO:0032525,GO:0046983,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|mesoderm formation|heart morphogenesis|nucleus|regulation of transcription by RNA polymerase II|Notch signaling pathway|somite rostral/caudal axis specification|protein dimerization activity|sequence-specific double-stranded DNA binding" MEST 145.2629129 231.4099608 59.11586499 0.255459466 -1.9688337 0.00146226 0.115903362 3.261925452 0.869184476 4232 mesoderm specific transcript "GO:0005515,GO:0005783,GO:0005789,GO:0007498,GO:0010883,GO:0016021,GO:0016787,GO:0070062" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|mesoderm development|regulation of lipid storage|integral component of membrane|hydrolase activity|extracellular exosome MET 6006.112522 6058.272175 5953.952869 0.982780683 -0.025058593 0.938927636 1 43.36208499 44.45111896 4233 "MET proto-oncogene, receptor tyrosine kinase" "GO:0000165,GO:0001886,GO:0001889,GO:0004713,GO:0004714,GO:0005008,GO:0005515,GO:0005524,GO:0005576,GO:0005886,GO:0005887,GO:0006909,GO:0007165,GO:0007166,GO:0007169,GO:0007275,GO:0007399,GO:0009925,GO:0009986,GO:0010507,GO:0016021,GO:0016477,GO:0017154,GO:0018108,GO:0019903,GO:0030182,GO:0031016,GO:0031116,GO:0033674,GO:0035024,GO:0035635,GO:0042802,GO:0043235,GO:0045944,GO:0048012,GO:0048754,GO:0050918,GO:0051497,GO:0051897,GO:0061436,GO:0070495,GO:0071526,GO:1901299,GO:1905098,GO:2001028" MAPK cascade|endothelial cell morphogenesis|liver development|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|hepatocyte growth factor-activated receptor activity|protein binding|ATP binding|extracellular region|plasma membrane|integral component of plasma membrane|phagocytosis|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|nervous system development|basal plasma membrane|cell surface|negative regulation of autophagy|integral component of membrane|cell migration|semaphorin receptor activity|peptidyl-tyrosine phosphorylation|protein phosphatase binding|neuron differentiation|pancreas development|positive regulation of microtubule polymerization|positive regulation of kinase activity|negative regulation of Rho protein signal transduction|entry of bacterium into host cell|identical protein binding|receptor complex|positive regulation of transcription by RNA polymerase II|hepatocyte growth factor receptor signaling pathway|branching morphogenesis of an epithelial tube|positive chemotaxis|negative regulation of stress fiber assembly|positive regulation of protein kinase B signaling|establishment of skin barrier|negative regulation of thrombin-activated receptor signaling pathway|semaphorin-plexin signaling pathway|negative regulation of hydrogen peroxide-mediated programmed cell death|negative regulation of guanyl-nucleotide exchange factor activity|positive regulation of endothelial cell chemotaxis "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04360,hsa04510,hsa04520,hsa05100,hsa05120,hsa05144,hsa05200,hsa05202,hsa05205,hsa05206,hsa05211,hsa05218,hsa05223,hsa05225,hsa05226,hsa05230" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Axon guidance|Focal adhesion|Adherens junction|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Malaria|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Renal cell carcinoma|Melanoma|Non-small cell lung cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer METAP1 1378.350284 1344.816658 1411.883909 1.049870925 0.070211969 0.835884986 1 12.28982669 13.45852907 23173 methionyl aminopeptidase 1 "GO:0004177,GO:0005515,GO:0005737,GO:0005829,GO:0006417,GO:0006508,GO:0008235,GO:0018206,GO:0022400,GO:0031365,GO:0046872,GO:0070006,GO:0070084,GO:0070527" aminopeptidase activity|protein binding|cytoplasm|cytosol|regulation of translation|proteolysis|metalloexopeptidase activity|peptidyl-methionine modification|regulation of rhodopsin mediated signaling pathway|N-terminal protein amino acid modification|metal ion binding|metalloaminopeptidase activity|protein initiator methionine removal|platelet aggregation METAP1D 72.33454093 95.40586103 49.26322083 0.51635424 -0.953566943 0.207311332 1 1.471815501 0.792714951 254042 "methionyl aminopeptidase type 1D, mitochondrial" "GO:0004177,GO:0005739,GO:0006508,GO:0008235,GO:0018206,GO:0031365,GO:0046872,GO:0070006,GO:0070084" aminopeptidase activity|mitochondrion|proteolysis|metalloexopeptidase activity|peptidyl-methionine modification|N-terminal protein amino acid modification|metal ion binding|metalloaminopeptidase activity|protein initiator methionine removal METAP2 2132.311881 2135.467357 2129.156404 0.997044697 -0.004269914 0.991040783 1 31.80996711 33.0821539 10988 methionyl aminopeptidase 2 "GO:0003723,GO:0004177,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0008235,GO:0016485,GO:0018206,GO:0022400,GO:0031365,GO:0046872,GO:0070006,GO:0070084" RNA binding|aminopeptidase activity|protein binding|cytoplasm|cytosol|plasma membrane|metalloexopeptidase activity|protein processing|peptidyl-methionine modification|regulation of rhodopsin mediated signaling pathway|N-terminal protein amino acid modification|metal ion binding|metalloaminopeptidase activity|protein initiator methionine removal METRN 632.9252534 767.3067121 498.5437948 0.649732091 -0.622083131 0.10757449 1 11.69818726 7.928094472 79006 "meteorin, glial cell differentiation regulator" "GO:0005179,GO:0005615,GO:0007165,GO:0010001,GO:0050772" hormone activity|extracellular space|signal transduction|glial cell differentiation|positive regulation of axonogenesis METRNL 586.8392747 614.0483609 559.6301886 0.911378035 -0.133878494 0.736235006 1 11.25158583 10.69616823 284207 "meteorin like, glial cell differentiation regulator" "GO:0003674,GO:0005179,GO:0005615,GO:0007165,GO:0009409,GO:0014850,GO:0045444,GO:0050728,GO:0050873,GO:0070062,GO:0090336,GO:0097009" molecular_function|hormone activity|extracellular space|signal transduction|response to cold|response to muscle activity|fat cell differentiation|negative regulation of inflammatory response|brown fat cell differentiation|extracellular exosome|positive regulation of brown fat cell differentiation|energy homeostasis METTL1 326.9118235 390.7580478 263.0655992 0.673218634 -0.570852985 0.21526401 1 12.8928447 9.053589713 4234 methyltransferase like 1 "GO:0000049,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006400,GO:0008176,GO:0030488,GO:0036265,GO:0043527,GO:0106004" tRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|tRNA modification|tRNA (guanine-N7-)-methyltransferase activity|tRNA methylation|RNA (guanine-N7)-methylation|tRNA methyltransferase complex|tRNA (guanine-N7)-methylation METTL14 449.0994569 391.7730038 506.4259101 1.29265137 0.370333231 0.378720138 1 2.957507907 3.987707132 57721 methyltransferase like 14 "GO:0000398,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006402,GO:0007283,GO:0016070,GO:0016422,GO:0019827,GO:0021861,GO:0036396,GO:0042063,GO:0045727,GO:0061157,GO:0080009,GO:1901533,GO:1904047" "mRNA splicing, via spliceosome|mRNA binding|protein binding|nucleus|nucleoplasm|mRNA catabolic process|spermatogenesis|RNA metabolic process|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|stem cell population maintenance|forebrain radial glial cell differentiation|RNA N6-methyladenosine methyltransferase complex|gliogenesis|positive regulation of translation|mRNA destabilization|mRNA methylation|negative regulation of hematopoietic progenitor cell differentiation|S-adenosyl-L-methionine binding" METTL15 289.2127165 272.0081995 306.4172335 1.126499988 0.171847298 0.724184779 1 3.210500051 3.772417948 196074 methyltransferase like 15 "GO:0005759,GO:0070475,GO:0071424" mitochondrial matrix|rRNA base methylation|rRNA (cytosine-N4-)-methyltransferase activity METTL16 729.3299869 790.6506994 668.0092744 0.844885453 -0.243172336 0.517046999 1 6.785912333 5.98028673 79066 methyltransferase like 16 "GO:0001734,GO:0003723,GO:0005634,GO:0005737,GO:0006402,GO:0006556,GO:0010608,GO:0030629,GO:0035613,GO:0048024,GO:0052907,GO:0061157,GO:0070475,GO:0080009,GO:0120048,GO:0120049,GO:1905869" "mRNA (N6-adenosine)-methyltransferase activity|RNA binding|nucleus|cytoplasm|mRNA catabolic process|S-adenosylmethionine biosynthetic process|posttranscriptional regulation of gene expression|U6 snRNA 3'-end binding|RNA stem-loop binding|regulation of mRNA splicing, via spliceosome|23S rRNA (adenine(1618)-N(6))-methyltransferase activity|mRNA destabilization|rRNA base methylation|mRNA methylation|U6 snRNA (adenine-(43)-N(6))-methyltransferase activity|snRNA (adenine-N6)-methylation|negative regulation of 3'-UTR-mediated mRNA stabilization" METTL17 923.733395 878.9518686 968.5149215 1.101897562 0.13999011 0.697029403 1 27.07774415 31.12215293 64745 methyltransferase like 17 "GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0006412,GO:0008168,GO:0032259,GO:0042274,GO:1904047" protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|translation|methyltransferase activity|methylation|ribosomal small subunit biogenesis|S-adenosyl-L-methionine binding METTL18 126.1326505 136.0040998 116.2612012 0.854836004 -0.226280422 0.726705391 1 3.30841876 2.94998094 92342 methyltransferase like 18 "GO:0005515,GO:0008150,GO:0018064,GO:0031072,GO:0032991,GO:0042038" "protein binding|biological_process|protein-histidine N-methyltransferase activity|heat shock protein binding|protein-containing complex|peptidyl-histidine methylation, to form tele-methylhistidine" METTL21A 135.3293589 124.8395841 145.8191336 1.168052062 0.224104579 0.722576833 1 0.906088353 1.103948155 151194 methyltransferase like 21A "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006479,GO:0008276,GO:0016279,GO:0018022,GO:0030544,GO:0031072,GO:0032991,GO:0043462,GO:0051117" protein binding|nucleoplasm|cytoplasm|cytosol|protein methylation|protein methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|Hsp70 protein binding|heat shock protein binding|protein-containing complex|regulation of ATPase activity|ATPase binding METTL22 322.6644478 302.4568786 342.872017 1.133622811 0.180940694 0.699591573 1 2.144229269 2.535453943 79091 methyltransferase like 22 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006479,GO:0008276,GO:0016279,GO:0018022,GO:0031072,GO:0032991" protein binding|nucleus|nucleoplasm|nucleolus|protein methylation|protein methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|heat shock protein binding|protein-containing complex METTL23 387.867327 348.1298972 427.6047568 1.22829082 0.296652185 0.499399745 1 12.15969046 15.57900279 124512 methyltransferase like 23 "GO:0005515,GO:0005634,GO:0005737,GO:0008134,GO:0008168,GO:0016021,GO:0031072,GO:0032259,GO:0032991,GO:0045944,GO:0050890" protein binding|nucleus|cytoplasm|transcription factor binding|methyltransferase activity|integral component of membrane|heat shock protein binding|methylation|protein-containing complex|positive regulation of transcription by RNA polymerase II|cognition METTL25 67.21522376 82.21143344 52.21901408 0.635179462 -0.65476383 0.399692332 1 0.26439669 0.175173494 84190 methyltransferase like 25 "GO:0008168,GO:0032259" methyltransferase activity|methylation METTL26 677.5496651 719.6037816 635.4955487 0.88311869 -0.179320748 0.639206126 1 40.85806382 37.6368084 84326 methyltransferase like 26 METTL27 199.9869037 267.9483757 132.0254318 0.492727121 -1.02113921 0.059291751 1 11.69882755 6.012633566 155368 methyltransferase like 27 "GO:0005515,GO:0008168" protein binding|methyltransferase activity METTL2A 486.1129366 497.3284245 474.8974488 0.954897057 -0.066582884 0.876118477 1 4.327823064 4.310642252 339175 methyltransferase like 2A "GO:0016427,GO:0030488,GO:0052735" tRNA (cytosine) methyltransferase activity|tRNA methylation|tRNA (cytosine-3-)-methyltransferase activity METTL2B 742.0223797 749.0375047 735.0072547 0.981268962 -0.027279467 0.945512261 1 6.494796638 6.647671482 55798 methyltransferase like 2B "GO:0016427,GO:0030488,GO:0052735" tRNA (cytosine) methyltransferase activity|tRNA methylation|tRNA (cytosine-3-)-methyltransferase activity METTL3 1033.107148 946.9539185 1119.260377 1.181958652 0.241179567 0.491939293 1 24.5822016 30.30672372 56339 methyltransferase like 3 "GO:0000398,GO:0001510,GO:0001734,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006382,GO:0006397,GO:0006402,GO:0006974,GO:0007283,GO:0007623,GO:0008168,GO:0008173,GO:0009048,GO:0016070,GO:0016422,GO:0016607,GO:0019827,GO:0021861,GO:0031053,GO:0034644,GO:0036396,GO:0042063,GO:0045087,GO:0045580,GO:0045727,GO:0045746,GO:0046982,GO:0051445,GO:0060339,GO:0061157,GO:0080009,GO:0098508,GO:1902036,GO:1903679,GO:1904047,GO:1990744" "mRNA splicing, via spliceosome|RNA methylation|mRNA (N6-adenosine)-methyltransferase activity|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|adenosine to inosine editing|mRNA processing|mRNA catabolic process|cellular response to DNA damage stimulus|spermatogenesis|circadian rhythm|methyltransferase activity|RNA methyltransferase activity|dosage compensation by inactivation of X chromosome|RNA metabolic process|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|nuclear speck|stem cell population maintenance|forebrain radial glial cell differentiation|primary miRNA processing|cellular response to UV|RNA N6-methyladenosine methyltransferase complex|gliogenesis|innate immune response|regulation of T cell differentiation|positive regulation of translation|negative regulation of Notch signaling pathway|protein heterodimerization activity|regulation of meiotic cell cycle|negative regulation of type I interferon-mediated signaling pathway|mRNA destabilization|mRNA methylation|endothelial to hematopoietic transition|regulation of hematopoietic stem cell differentiation|positive regulation of cap-independent translational initiation|S-adenosyl-L-methionine binding|primary miRNA methylation" METTL4 458.0883245 366.3991046 549.7775444 1.500488231 0.585432004 0.161548958 1 5.150380813 8.060980391 64863 methyltransferase like 4 "GO:0001510,GO:0003676,GO:0005634,GO:0005759,GO:0005829,GO:0006325,GO:0008168,GO:0008173,GO:0009007,GO:0032775,GO:0043484,GO:0090296,GO:0120049,GO:1902275,GO:1903108" RNA methylation|nucleic acid binding|nucleus|mitochondrial matrix|cytosol|chromatin organization|methyltransferase activity|RNA methyltransferase activity|site-specific DNA-methyltransferase (adenine-specific) activity|DNA methylation on adenine|regulation of RNA splicing|regulation of mitochondrial DNA replication|snRNA (adenine-N6)-methylation|regulation of chromatin organization|regulation of mitochondrial transcription METTL5 424.8565583 384.668312 465.0448046 1.208950127 0.27375473 0.522624539 1 22.65359648 28.56679217 29081 methyltransferase like 5 "GO:0003676,GO:0005515,GO:0005634,GO:0008988,GO:0031167,GO:0042995,GO:0045727,GO:0048863,GO:0098793,GO:0098794,GO:1904047" nucleic acid binding|protein binding|nucleus|rRNA (adenine-N6-)-methyltransferase activity|rRNA methylation|cell projection|positive regulation of translation|stem cell differentiation|presynapse|postsynapse|S-adenosyl-L-methionine binding METTL6 538.0444378 545.031355 531.0575205 0.974361412 -0.037471096 0.930359152 1 2.629445168 2.672391764 131965 methyltransferase like 6 "GO:0005515,GO:0005575,GO:0019899,GO:0030488,GO:0052735" protein binding|cellular_component|enzyme binding|tRNA methylation|tRNA (cytosine-3-)-methyltransferase activity METTL7A 28.39179717 21.31407534 35.469519 1.664135949 0.734773297 0.473673785 1 0.346321054 0.601151073 25840 methyltransferase like 7A "GO:0005515,GO:0005576,GO:0005783,GO:0005811,GO:0008168,GO:0016020,GO:0032259,GO:0043312,GO:1904724" protein binding|extracellular region|endoplasmic reticulum|lipid droplet|methyltransferase activity|membrane|methylation|neutrophil degranulation|tertiary granule lumen METTL7B 18.00198346 18.26920743 17.7347595 0.970745971 -0.042834281 1 1 0.703093394 0.711925491 196410 methyltransferase like 7B "GO:0008168,GO:0032259" methyltransferase activity|methylation METTL8 317.9932255 286.2175831 349.7688679 1.222038367 0.289289581 0.535585281 1 1.416446245 1.805514033 79828 methyltransferase like 8 "GO:0005634,GO:0005737,GO:0008174,GO:0030488,GO:0052735,GO:0080009" nucleus|cytoplasm|mRNA methyltransferase activity|tRNA methylation|tRNA (cytosine-3-)-methyltransferase activity|mRNA methylation METTL9 1237.382005 1171.259188 1303.504823 1.112908942 0.154335556 0.651447913 1 18.2748447 21.21432689 51108 methyltransferase like 9 GO:0005515 protein binding MEX3A 426.2399371 445.5656701 406.914204 0.913253043 -0.130913439 0.762598952 1 3.423809639 3.261494631 92312 mex-3 RNA binding family member A "GO:0000932,GO:0003723,GO:0005634,GO:0005829,GO:0046872" P-body|RNA binding|nucleus|cytosol|metal ion binding MEX3B 122.6396877 132.9592319 112.3201435 0.844771303 -0.243367269 0.708860345 1 1.977655225 1.742631913 84206 mex-3 RNA binding family member B "GO:0000932,GO:0003723,GO:0005509,GO:0005654,GO:0005829,GO:0006468,GO:0046777" P-body|RNA binding|calcium ion binding|nucleoplasm|cytosol|protein phosphorylation|protein autophosphorylation MEX3C 1679.452237 1722.380278 1636.524196 0.950152656 -0.073768773 0.823094159 1 21.06047439 20.87264399 51320 mex-3 RNA binding family member C "GO:0003415,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0016567,GO:0045598,GO:0046872,GO:0061630,GO:0097009" chondrocyte hypertrophy|RNA binding|protein binding|nucleus|cytoplasm|protein ubiquitination|regulation of fat cell differentiation|metal ion binding|ubiquitin protein ligase activity|energy homeostasis MEX3D 572.0778759 581.5697699 562.5859818 0.967357677 -0.047878675 0.907974353 1 8.393974691 8.46975149 399664 mex-3 RNA binding family member D "GO:0003723,GO:0005634,GO:0010609,GO:0035925,GO:0046872,GO:0048471,GO:0061157" RNA binding|nucleus|mRNA localization resulting in posttranscriptional regulation of gene expression|mRNA 3'-UTR AU-rich region binding|metal ion binding|perinuclear region of cytoplasm|mRNA destabilization MFAP1 660.2805679 684.0803227 636.4808131 0.930418245 -0.104048708 0.788638903 1 16.95851936 16.45819029 4236 microfibril associated protein 1 "GO:0000398,GO:0001527,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005684,GO:0005813,GO:0071005" "mRNA splicing, via spliceosome|microfibril|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|U2-type spliceosomal complex|centrosome|U2-type precatalytic spliceosome" MFAP2 598.8487619 525.7471916 671.9503321 1.278086394 0.35398536 0.365949318 1 23.88093321 31.83665529 4237 microfibril associated protein 2 "GO:0001527,GO:0005201,GO:0005515,GO:0005576,GO:0030198,GO:0048048,GO:0048050,GO:0062023,GO:0120162" microfibril|extracellular matrix structural constituent|protein binding|extracellular region|extracellular matrix organization|embryonic eye morphogenesis|post-embryonic eye morphogenesis|collagen-containing extracellular matrix|positive regulation of cold-induced thermogenesis MFAP3 848.9072393 949.9987864 747.8156922 0.787175418 -0.345242925 0.341955449 1 9.552131653 7.843100011 4238 microfibril associated protein 3 "GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005886,GO:0016021" protein binding|extracellular region|nucleus|cytoplasm|plasma membrane|integral component of membrane MFAP3L 155.2546122 173.5574706 136.9517539 0.789085906 -0.341745723 0.563742606 1 0.843415238 0.694195285 9848 microfibril associated protein 3 like "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0016021,GO:0030054" protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|integral component of membrane|cell junction MFF 930.8947483 930.714623 931.0748736 1.000387069 0.000558314 1 1 20.28287964 21.16477289 56947 mitochondrial fission factor "GO:0000266,GO:0001836,GO:0005515,GO:0005739,GO:0005741,GO:0005777,GO:0006626,GO:0008021,GO:0008053,GO:0010821,GO:0016559,GO:0031307,GO:0032592,GO:0032991,GO:0042802,GO:0042803,GO:0043653,GO:0070584,GO:0090141,GO:0090200,GO:0090314,GO:1900063" mitochondrial fission|release of cytochrome c from mitochondria|protein binding|mitochondrion|mitochondrial outer membrane|peroxisome|protein targeting to mitochondrion|synaptic vesicle|mitochondrial fusion|regulation of mitochondrion organization|peroxisome fission|integral component of mitochondrial outer membrane|integral component of mitochondrial membrane|protein-containing complex|identical protein binding|protein homodimerization activity|mitochondrial fragmentation involved in apoptotic process|mitochondrion morphogenesis|positive regulation of mitochondrial fission|positive regulation of release of cytochrome c from mitochondria|positive regulation of protein targeting to membrane|regulation of peroxisome organization MFGE8 880.8719174 541.9864871 1219.757348 2.25053092 1.170265386 0.001325002 0.108804729 5.536446865 12.99666875 4240 milk fat globule EGF and factor V/VIII domain containing "GO:0001525,GO:0001786,GO:0005178,GO:0005201,GO:0005576,GO:0005615,GO:0005788,GO:0006910,GO:0006911,GO:0007155,GO:0007338,GO:0008429,GO:0009897,GO:0016020,GO:0019897,GO:0043277,GO:0043687,GO:0044267,GO:0050766,GO:0062023,GO:0070062,GO:1903561" "angiogenesis|phosphatidylserine binding|integrin binding|extracellular matrix structural constituent|extracellular region|extracellular space|endoplasmic reticulum lumen|phagocytosis, recognition|phagocytosis, engulfment|cell adhesion|single fertilization|phosphatidylethanolamine binding|external side of plasma membrane|membrane|extrinsic component of plasma membrane|apoptotic cell clearance|post-translational protein modification|cellular protein metabolic process|positive regulation of phagocytosis|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle" MFHAS1 1274.164634 1362.07091 1186.258358 0.870922614 -0.199383561 0.557113481 1 10.88420424 9.887629395 9258 malignant fibrous histiocytoma amplified sequence 1 "GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005764,GO:0005856,GO:0006954,GO:0030218,GO:0031625,GO:0034136,GO:0034137,GO:0034144,GO:0035308,GO:0043030,GO:0045087,GO:0046330,GO:0050728,GO:0051721,GO:0051897,GO:0070374,GO:1900181,GO:1900745" protein binding|GTP binding|cytoplasm|mitochondrion|lysosome|cytoskeleton|inflammatory response|erythrocyte differentiation|ubiquitin protein ligase binding|negative regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of protein dephosphorylation|regulation of macrophage activation|innate immune response|positive regulation of JNK cascade|negative regulation of inflammatory response|protein phosphatase 2A binding|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|negative regulation of protein localization to nucleus|positive regulation of p38MAPK cascade MFN1 1270.890398 1239.261237 1302.519559 1.051045187 0.071824695 0.834177424 1 17.31426478 18.98197391 55669 mitofusin 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0008053,GO:0010918,GO:0016021,GO:0016236,GO:0031306,GO:0031307,GO:0042802,GO:0046039,GO:0051646,GO:0098799,GO:1990613" GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial outer membrane|mitochondrial fusion|positive regulation of mitochondrial membrane potential|integral component of membrane|macroautophagy|intrinsic component of mitochondrial outer membrane|integral component of mitochondrial outer membrane|identical protein binding|GTP metabolic process|mitochondrion localization|outer mitochondrial membrane protein complex|mitochondrial membrane fusion "hsa04137,hsa04621,hsa05012,hsa05022" Mitophagy - animal|NOD-like receptor signaling pathway|Parkinson disease|Pathways of neurodegeneration - multiple diseases MFN2 4026.89173 4083.167861 3970.615599 0.972435064 -0.04032618 0.900039363 1 42.54228504 43.15164467 9927 mitofusin 2 "GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0005829,GO:0006626,GO:0006915,GO:0006986,GO:0007006,GO:0007050,GO:0007596,GO:0008053,GO:0016021,GO:0016236,GO:0031306,GO:0031625,GO:0034497,GO:0046580,GO:0048662,GO:0051646,GO:0061734,GO:0120162,GO:1904707,GO:1905461" GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial outer membrane|cytosol|protein targeting to mitochondrion|apoptotic process|response to unfolded protein|mitochondrial membrane organization|cell cycle arrest|blood coagulation|mitochondrial fusion|integral component of membrane|macroautophagy|intrinsic component of mitochondrial outer membrane|ubiquitin protein ligase binding|protein localization to phagophore assembly site|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|mitochondrion localization|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|positive regulation of cold-induced thermogenesis|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell apoptotic process "hsa04137,hsa04621,hsa05012,hsa05022" Mitophagy - animal|NOD-like receptor signaling pathway|Parkinson disease|Pathways of neurodegeneration - multiple diseases MFSD1 586.7677675 575.4800341 598.0555008 1.039228931 0.0555135 0.891824229 1 12.70533285 13.77251346 64747 major facilitator superfamily domain containing 1 "GO:0005764,GO:0016021,GO:0022857,GO:0042803,GO:0050821,GO:0055085,GO:0061462" lysosome|integral component of membrane|transmembrane transporter activity|protein homodimerization activity|protein stabilization|transmembrane transport|protein localization to lysosome MFSD10 1477.909249 1314.367979 1641.450518 1.248851573 0.320602022 0.334585207 1 32.03469746 41.72990363 10227 major facilitator superfamily domain containing 10 "GO:0005515,GO:0005637,GO:0006915,GO:0008493,GO:0008514,GO:0015904,GO:0016021,GO:0030659,GO:0031526,GO:0043252" protein binding|nuclear inner membrane|apoptotic process|tetracycline transmembrane transporter activity|organic anion transmembrane transporter activity|tetracycline transmembrane transport|integral component of membrane|cytoplasmic vesicle membrane|brush border membrane|sodium-independent organic anion transport MFSD11 331.7572358 284.1876711 379.3268004 1.334775709 0.416597337 0.364212475 1 2.46457243 3.431356255 79157 major facilitator superfamily domain containing 11 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane MFSD12 1363.756148 1458.491727 1269.020569 0.87009103 -0.20076175 0.550458802 1 25.4102032 23.06156411 126321 major facilitator superfamily domain containing 12 "GO:0005215,GO:0005765,GO:0005770,GO:0005887,GO:0008643,GO:0015293,GO:0048022,GO:0055085,GO:0071702" transporter activity|lysosomal membrane|late endosome|integral component of plasma membrane|carbohydrate transport|symporter activity|negative regulation of melanin biosynthetic process|transmembrane transport|organic substance transport MFSD13A 440.1078678 450.64045 429.5752856 0.953255052 -0.069065823 0.875102451 1 5.720137601 5.687632425 79847 major facilitator superfamily domain containing 13A "GO:0005515,GO:0016021" protein binding|integral component of membrane MFSD14A 1285.384573 1253.470621 1317.298525 1.050920941 0.071654142 0.834276394 1 20.32784661 22.28318936 64645 major facilitator superfamily domain containing 14A "GO:0016021,GO:0022857,GO:0055085" integral component of membrane|transmembrane transporter activity|transmembrane transport MFSD14B 2664.268067 2466.343003 2862.19313 1.160500841 0.214747569 0.500562205 1 34.24111085 41.44853977 84641 major facilitator superfamily domain containing 14B "GO:0005515,GO:0016021,GO:0022857,GO:0055085" protein binding|integral component of membrane|transmembrane transporter activity|transmembrane transport MFSD14C 222.8936825 183.7070303 262.0803348 1.42662115 0.512602267 0.325460936 1 3.508338237 5.220667627 84278 "GO:0005515,GO:0016021,GO:0022857,GO:0055085" protein binding|integral component of membrane|transmembrane transporter activity|transmembrane transport MFSD2A 385.2623891 439.4759343 331.048844 0.753280938 -0.408740073 0.351700368 1 10.29505351 8.089124424 84879 major facilitator superfamily domain containing 2A "GO:0003406,GO:0005215,GO:0005324,GO:0005548,GO:0005789,GO:0005886,GO:0005887,GO:0006656,GO:0007420,GO:0008594,GO:0008643,GO:0009267,GO:0010867,GO:0015245,GO:0015293,GO:0015711,GO:0015908,GO:0015909,GO:0016021,GO:0021766,GO:0030307,GO:0031999,GO:0034379,GO:0035633,GO:0035845,GO:0040014,GO:0045056,GO:0050773,GO:0050890,GO:0051977,GO:0051978,GO:0055085,GO:0060042,GO:0060856,GO:0061744,GO:0071702,GO:0097009,GO:0140329,GO:0140348,GO:0150011,GO:0150104,GO:0150172,GO:0150175,GO:0150178,GO:1901480,GO:1990379,GO:1990403,GO:1990963" retinal pigment epithelium development|transporter activity|long-chain fatty acid transporter activity|phospholipid transporter activity|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|phosphatidylcholine biosynthetic process|brain development|photoreceptor cell morphogenesis|carbohydrate transport|cellular response to starvation|positive regulation of triglyceride biosynthetic process|fatty acid transmembrane transporter activity|symporter activity|organic anion transport|fatty acid transport|long-chain fatty acid transport|integral component of membrane|hippocampus development|positive regulation of cell growth|negative regulation of fatty acid beta-oxidation|very-low-density lipoprotein particle assembly|maintenance of blood-brain barrier|photoreceptor cell outer segment organization|regulation of multicellular organism growth|transcytosis|regulation of dendrite development|cognition|lysophospholipid transport|lysophospholipid:sodium symporter activity|transmembrane transport|retina morphogenesis in camera-type eye|establishment of blood-brain barrier|motor behavior|organic substance transport|energy homeostasis|lysophospholipid translocation|lysophosphatidylcholine flippase activity|regulation of neuron projection arborization|transport across blood-brain barrier|regulation of phosphatidylcholine metabolic process|regulation of phosphatidylethanolamine metabolic process|regulation of phosphatidylserine metabolic process|oleate transmembrane transporter activity|lipid transport across blood-brain barrier|embryonic brain development|establishment of blood-retinal barrier MFSD2B 108.3412295 98.45072893 118.23173 1.20092285 0.264143472 0.697558524 1 0.999435179 1.251946211 388931 major facilitator superfamily domain containing 2B "GO:0005215,GO:0005887,GO:0006869,GO:0008643,GO:0015293,GO:0046624,GO:0055085,GO:0071702" transporter activity|integral component of plasma membrane|lipid transport|carbohydrate transport|symporter activity|sphingolipid transporter activity|transmembrane transport|organic substance transport MFSD3 440.7786493 462.8199216 418.737377 0.904752275 -0.144405264 0.735919805 1 9.224791931 8.705669845 113655 major facilitator superfamily domain containing 3 "GO:0005515,GO:0015295,GO:0016021,GO:1902600" protein binding|solute:proton symporter activity|integral component of membrane|proton transmembrane transport MFSD4A 6.508139139 7.104691779 5.911586499 0.832067975 -0.265226703 0.975312627 1 0.097303292 0.084450509 148808 major facilitator superfamily domain containing 4A "GO:0005355,GO:0016021,GO:1904659" glucose transmembrane transporter activity|integral component of membrane|glucose transmembrane transport MFSD4B 168.9119805 197.9164138 139.9075471 0.706902194 -0.500417475 0.381136051 1 0.674320091 0.497211722 91749 major facilitator superfamily domain containing 4B "GO:0005355,GO:0005515,GO:0006814,GO:0015293,GO:0016021,GO:0016324,GO:1904659" glucose transmembrane transporter activity|protein binding|sodium ion transport|symporter activity|integral component of membrane|apical plasma membrane|glucose transmembrane transport MFSD5 665.6225717 712.4990898 618.7460536 0.868416623 -0.203540753 0.595627194 1 13.48993097 12.21950983 84975 major facilitator superfamily domain containing 5 "GO:0005515,GO:0005886,GO:0015098,GO:0015689,GO:0016020,GO:0016021" protein binding|plasma membrane|molybdate ion transmembrane transporter activity|molybdate ion transport|membrane|integral component of membrane MFSD6 550.0836164 458.7600977 641.4071352 1.398131918 0.48350049 0.225935457 1 4.286032197 6.250568359 54842 major facilitator superfamily domain containing 6 "GO:0005515,GO:0005886,GO:0016020,GO:0016021,GO:0042590" protein binding|plasma membrane|membrane|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class I MFSD8 262.8508313 254.7539481 270.9477146 1.063566302 0.088909973 0.863995065 1 2.438093112 2.704772774 256471 major facilitator superfamily domain containing 8 "GO:0005765,GO:0007040,GO:0010506,GO:0016021,GO:0022857,GO:0038202,GO:0048666,GO:0055085,GO:0097352,GO:1905165" lysosomal membrane|lysosome organization|regulation of autophagy|integral component of membrane|transmembrane transporter activity|TORC1 signaling|neuron development|transmembrane transport|autophagosome maturation|regulation of lysosomal protein catabolic process hsa04142 Lysosome MFSD9 245.2969427 233.4398727 257.1540127 1.101585645 0.139581664 0.788251288 1 2.138731192 2.457482313 84804 major facilitator superfamily domain containing 9 "GO:0016021,GO:0022857,GO:0055085" integral component of membrane|transmembrane transporter activity|transmembrane transport MGA 1474.530846 1554.912544 1394.149149 0.896609366 -0.157448525 0.636458134 1 6.556559398 6.131901935 23269 MAX dimerization protein MGA "GO:0000785,GO:0000978,GO:0000981,GO:0001708,GO:0005515,GO:0005654,GO:0006357,GO:0046983,GO:0070317,GO:0071339" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cell fate specification|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|protein dimerization activity|negative regulation of G0 to G1 transition|MLL1 complex" MGAM 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.021602832 0.016405652 8972 maltase-glucoamylase "GO:0000023,GO:0003824,GO:0004339,GO:0004553,GO:0004558,GO:0005515,GO:0005886,GO:0005983,GO:0016021,GO:0016324,GO:0030246,GO:0032450,GO:0043312,GO:0044245,GO:0070062,GO:0070821,GO:0101003" "maltose metabolic process|catalytic activity|glucan 1,4-alpha-glucosidase activity|hydrolase activity, hydrolyzing O-glycosyl compounds|alpha-1,4-glucosidase activity|protein binding|plasma membrane|starch catabolic process|integral component of membrane|apical plasma membrane|carbohydrate binding|maltose alpha-glucosidase activity|neutrophil degranulation|polysaccharide digestion|extracellular exosome|tertiary granule membrane|ficolin-1-rich granule membrane" "hsa00052,hsa00500,hsa04973" Galactose metabolism|Starch and sucrose metabolism|Carbohydrate digestion and absorption MGAT1 2782.259296 2854.056183 2710.46241 0.949687825 -0.074474736 0.815904466 1 13.3630283 13.23736941 4245 "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase" "GO:0000139,GO:0001701,GO:0003827,GO:0005515,GO:0005794,GO:0006049,GO:0006486,GO:0006487,GO:0016020,GO:0016021,GO:0018215,GO:0018279,GO:0030145,GO:0048471,GO:0070062,GO:1903561" "Golgi membrane|in utero embryonic development|alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|protein binding|Golgi apparatus|UDP-N-acetylglucosamine catabolic process|protein glycosylation|protein N-linked glycosylation|membrane|integral component of membrane|protein phosphopantetheinylation|protein N-linked glycosylation via asparagine|manganese ion binding|perinuclear region of cytoplasm|extracellular exosome|extracellular vesicle" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MGAT2 947.6751727 1101.227226 794.1231197 0.721125578 -0.47167758 0.185029294 1 20.7876534 15.63623889 4247 "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase" "GO:0000139,GO:0005794,GO:0005795,GO:0006487,GO:0008455,GO:0009312,GO:0016020,GO:0016021,GO:0018215,GO:0018279,GO:0030145,GO:0030246,GO:0042803" "Golgi membrane|Golgi apparatus|Golgi stack|protein N-linked glycosylation|alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|oligosaccharide biosynthetic process|membrane|integral component of membrane|protein phosphopantetheinylation|protein N-linked glycosylation via asparagine|manganese ion binding|carbohydrate binding|protein homodimerization activity" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MGAT3 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.046586858 0.018868829 4248 "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase" "GO:0000139,GO:0003830,GO:0005515,GO:0006044,GO:0006487,GO:0008104,GO:0016021,GO:0016757,GO:0018215,GO:0030334,GO:0034599,GO:0050435,GO:0050890,GO:1902966,GO:1905166" "Golgi membrane|beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|protein binding|N-acetylglucosamine metabolic process|protein N-linked glycosylation|protein localization|integral component of membrane|transferase activity, transferring glycosyl groups|protein phosphopantetheinylation|regulation of cell migration|cellular response to oxidative stress|amyloid-beta metabolic process|cognition|positive regulation of protein localization to early endosome|negative regulation of lysosomal protein catabolic process" hsa00510 N-Glycan biosynthesis MGAT4A 40.24466172 23.34398727 57.14533616 2.4479681 1.291584758 0.157258275 1 0.266641994 0.680848104 11320 "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A" "GO:0000139,GO:0005783,GO:0005788,GO:0005793,GO:0005795,GO:0006487,GO:0006491,GO:0008375,GO:0008454,GO:0016021,GO:0018215,GO:0043687,GO:0044267,GO:0046872,GO:0070062" "Golgi membrane|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|Golgi stack|protein N-linked glycosylation|N-glycan processing|acetylglucosaminyltransferase activity|alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|integral component of membrane|protein phosphopantetheinylation|post-translational protein modification|cellular protein metabolic process|metal ion binding|extracellular exosome" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MGAT4B 5524.012397 5229.053149 5818.971644 1.112815548 0.154214482 0.632974477 1 101.6633762 118.0058786 11282 "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B" "GO:0000139,GO:0005515,GO:0005783,GO:0005793,GO:0005795,GO:0006487,GO:0006491,GO:0008375,GO:0008454,GO:0016021,GO:0018215,GO:0046872" "Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi stack|protein N-linked glycosylation|N-glycan processing|acetylglucosaminyltransferase activity|alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|integral component of membrane|protein phosphopantetheinylation|metal ion binding" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MGAT5 1794.628213 1850.26473 1738.991695 0.939861019 -0.089480659 0.784353222 1 9.245203359 9.063502017 4249 "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase" "GO:0000139,GO:0004864,GO:0005794,GO:0006487,GO:0016020,GO:0016021,GO:0018215,GO:0018279,GO:0030144,GO:0030145,GO:0030335,GO:0070062,GO:1903614,GO:1904894" "Golgi membrane|protein phosphatase inhibitor activity|Golgi apparatus|protein N-linked glycosylation|membrane|integral component of membrane|protein phosphopantetheinylation|protein N-linked glycosylation via asparagine|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity|manganese ion binding|positive regulation of cell migration|extracellular exosome|negative regulation of protein tyrosine phosphatase activity|positive regulation of receptor signaling pathway via STAT" hsa00510 N-Glycan biosynthesis MGAT5B 122.4318468 118.7498483 126.1138453 1.062012686 0.086800999 0.903740794 1 0.750844056 0.831754926 146664 "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B" "GO:0000139,GO:0005515,GO:0005794,GO:0006487,GO:0016021,GO:0018215,GO:0018242,GO:0030144,GO:0030145" "Golgi membrane|protein binding|Golgi apparatus|protein N-linked glycosylation|integral component of membrane|protein phosphopantetheinylation|protein O-linked glycosylation via serine|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity|manganese ion binding" "hsa00510,hsa00515" N-Glycan biosynthesis|Mannose type O-glycan biosynthesis MGLL 3356.905738 3240.754407 3473.057068 1.071681662 0.099876423 0.754064892 1 30.47396547 34.06518094 11343 monoglyceride lipase "GO:0004622,GO:0005515,GO:0005654,GO:0005789,GO:0005829,GO:0005886,GO:0006629,GO:0006633,GO:0006954,GO:0009966,GO:0016020,GO:0016298,GO:0019369,GO:0019433,GO:0019898,GO:0036155,GO:0042803,GO:0046464,GO:0047372,GO:0050727,GO:0051930,GO:0052651,GO:2000124" lysophospholipase activity|protein binding|nucleoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|lipid metabolic process|fatty acid biosynthetic process|inflammatory response|regulation of signal transduction|membrane|lipase activity|arachidonic acid metabolic process|triglyceride catabolic process|extrinsic component of membrane|acylglycerol acyl-chain remodeling|protein homodimerization activity|acylglycerol catabolic process|acylglycerol lipase activity|regulation of inflammatory response|regulation of sensory perception of pain|monoacylglycerol catabolic process|regulation of endocannabinoid signaling pathway "hsa00561,hsa04714,hsa04723,hsa04923" Glycerolipid metabolism|Thermogenesis|Retrograde endocannabinoid signaling|Regulation of lipolysis in adipocytes MGME1 1119.512017 1128.631037 1110.392997 0.983840565 -0.023503554 0.948536686 1 18.12339266 18.59859575 92667 mitochondrial genome maintenance exonuclease 1 "GO:0000002,GO:0005515,GO:0005739,GO:0006264,GO:0008297,GO:0043504,GO:0090305" mitochondrial genome maintenance|protein binding|mitochondrion|mitochondrial DNA replication|single-stranded DNA exodeoxyribonuclease activity|mitochondrial DNA repair|nucleic acid phosphodiester bond hydrolysis MGMT 214.4568303 213.1407534 215.7729072 1.012349369 0.017707261 0.983134538 1 2.204825826 2.328201869 4255 O-6-methylguanine-DNA methyltransferase "GO:0003677,GO:0003908,GO:0005634,GO:0005654,GO:0006266,GO:0006281,GO:0006306,GO:0006307,GO:0008168,GO:0009008,GO:0016020,GO:0043066,GO:0046872,GO:2000781" DNA binding|methylated-DNA-[protein]-cysteine S-methyltransferase activity|nucleus|nucleoplasm|DNA ligation|DNA repair|DNA methylation|DNA dealkylation involved in DNA repair|methyltransferase activity|DNA-methyltransferase activity|membrane|negative regulation of apoptotic process|metal ion binding|positive regulation of double-strand break repair MGRN1 578.3215126 536.9117073 619.731318 1.154251825 0.206958014 0.601598215 1 4.204837461 5.062507882 23295 mahogunin ring finger 1 "GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005829,GO:0005886,GO:0006513,GO:0008333,GO:0016020,GO:0016567,GO:0043231,GO:0043951,GO:0045744,GO:0045879,GO:0046872,GO:0061630,GO:0070062" ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|early endosome|endoplasmic reticulum|cytosol|plasma membrane|protein monoubiquitination|endosome to lysosome transport|membrane|protein ubiquitination|intracellular membrane-bounded organelle|negative regulation of cAMP-mediated signaling|negative regulation of G protein-coupled receptor signaling pathway|negative regulation of smoothened signaling pathway|metal ion binding|ubiquitin protein ligase activity|extracellular exosome "hsa04120,hsa04340" Ubiquitin mediated proteolysis|Hedgehog signaling pathway MGST1 1621.792742 1619.869726 1623.715758 1.002374285 0.00342131 0.993829728 1 36.54373588 38.20839456 4257 microsomal glutathione S-transferase 1 "GO:0004364,GO:0004602,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005886,GO:0006805,GO:0010243,GO:0016021,GO:0032496,GO:0033327,GO:0035577,GO:0042493,GO:0042802,GO:0043295,GO:0043312,GO:0045177,GO:0055114,GO:0071449,GO:0098869,GO:1901687" glutathione transferase activity|glutathione peroxidase activity|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|xenobiotic metabolic process|response to organonitrogen compound|integral component of membrane|response to lipopolysaccharide|Leydig cell differentiation|azurophil granule membrane|response to drug|identical protein binding|glutathione binding|neutrophil degranulation|apical part of cell|oxidation-reduction process|cellular response to lipid hydroperoxide|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis MGST2 325.9171565 322.7559979 329.0783151 1.019588535 0.027987056 0.958774269 1 4.518090846 4.805026998 4258 microsomal glutathione S-transferase 2 "GO:0004364,GO:0004464,GO:0004602,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005886,GO:0006629,GO:0006750,GO:0006805,GO:0008047,GO:0010243,GO:0016020,GO:0016021,GO:0019370,GO:0032496,GO:0042802,GO:0043231,GO:0043295,GO:0046466,GO:0050729,GO:0050790,GO:0055114,GO:0098869,GO:1901687" glutathione transferase activity|leukotriene-C4 synthase activity|glutathione peroxidase activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|lipid metabolic process|glutathione biosynthetic process|xenobiotic metabolic process|enzyme activator activity|response to organonitrogen compound|membrane|integral component of membrane|leukotriene biosynthetic process|response to lipopolysaccharide|identical protein binding|intracellular membrane-bounded organelle|glutathione binding|membrane lipid catabolic process|positive regulation of inflammatory response|regulation of catalytic activity|oxidation-reduction process|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis MGST3 1465.239866 1256.515489 1673.964244 1.332227305 0.413840257 0.213460267 1 95.55266785 132.7813493 4259 microsomal glutathione S-transferase 3 "GO:0004364,GO:0004464,GO:0004602,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0006629,GO:0006805,GO:0016020,GO:0016021,GO:0019370,GO:0042802,GO:0043231,GO:0055114,GO:0098869,GO:1901687" glutathione transferase activity|leukotriene-C4 synthase activity|glutathione peroxidase activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|lipid metabolic process|xenobiotic metabolic process|membrane|integral component of membrane|leukotriene biosynthetic process|identical protein binding|intracellular membrane-bounded organelle|oxidation-reduction process|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis MIA 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.38076992 0 8190 MIA SH3 domain containing "GO:0005615,GO:0007165,GO:0008083,GO:0030198" extracellular space|signal transduction|growth factor activity|extracellular matrix organization MIA2 386.6863459 368.4290165 404.9436752 1.099109074 0.136334564 0.759787964 1 2.224032175 2.549751107 4253 MIA SH3 domain ER export factor 2 "GO:0005515,GO:0005783,GO:0005789,GO:0006888,GO:0009306,GO:0016020,GO:0016021,GO:0035459,GO:0070971" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|membrane|integral component of membrane|vesicle cargo loading|endoplasmic reticulum exit site MIA3 1222.998432 1265.650093 1180.346771 0.932601181 -0.100667838 0.769541983 1 6.902941228 6.715000767 375056 MIA SH3 domain ER export factor 3 "GO:0000139,GO:0002042,GO:0002687,GO:0005515,GO:0005788,GO:0005789,GO:0006887,GO:0006888,GO:0006897,GO:0007029,GO:0007162,GO:0009306,GO:0015031,GO:0016020,GO:0016021,GO:0030336,GO:0035459,GO:0038024,GO:0042060,GO:0042953,GO:0043231,GO:0043687,GO:0044267,GO:0070971,GO:0070973,GO:0090110,GO:0140052,GO:1903038,GO:2000402" Golgi membrane|cell migration involved in sprouting angiogenesis|positive regulation of leukocyte migration|protein binding|endoplasmic reticulum lumen|endoplasmic reticulum membrane|exocytosis|endoplasmic reticulum to Golgi vesicle-mediated transport|endocytosis|endoplasmic reticulum organization|negative regulation of cell adhesion|protein secretion|protein transport|membrane|integral component of membrane|negative regulation of cell migration|vesicle cargo loading|cargo receptor activity|wound healing|lipoprotein transport|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process|endoplasmic reticulum exit site|protein localization to endoplasmic reticulum exit site|COPII-coated vesicle cargo loading|cellular response to oxidised low-density lipoprotein particle stimulus|negative regulation of leukocyte cell-cell adhesion|negative regulation of lymphocyte migration MIB1 1650.615067 1670.617524 1630.612609 0.976053816 -0.0349674 0.916884513 1 8.970619593 9.132972162 57534 MIB E3 ubiquitin protein ligase 1 "GO:0001568,GO:0001701,GO:0001756,GO:0001841,GO:0001947,GO:0004842,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0006511,GO:0006897,GO:0007219,GO:0008270,GO:0014069,GO:0016567,GO:0031410,GO:0045665,GO:0045807" blood vessel development|in utero embryonic development|somitogenesis|neural tube formation|heart looping|ubiquitin-protein transferase activity|protein binding|cytoplasm|centrosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|endocytosis|Notch signaling pathway|zinc ion binding|postsynaptic density|protein ubiquitination|cytoplasmic vesicle|negative regulation of neuron differentiation|positive regulation of endocytosis MIB2 522.2977745 512.552764 532.0427849 1.038025394 0.053841738 0.898632238 1 2.749601665 2.977101833 142678 MIB E3 ubiquitin protein ligase 2 "GO:0000151,GO:0000209,GO:0003779,GO:0004842,GO:0005515,GO:0005737,GO:0005769,GO:0005829,GO:0007219,GO:0008270,GO:0016567,GO:0043123,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|actin binding|ubiquitin-protein transferase activity|protein binding|cytoplasm|early endosome|cytosol|Notch signaling pathway|zinc ion binding|protein ubiquitination|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin protein ligase activity MICA 406.3619426 366.3991046 446.3247807 1.218138295 0.284677932 0.511355747 1 13.04063392 16.56956968 100507436 MHC class I polypeptide-related sequence A "GO:0001913,GO:0002418,GO:0005515,GO:0005615,GO:0005737,GO:0005886,GO:0005887,GO:0006955,GO:0006974,GO:0009408,GO:0009897,GO:0009986,GO:0016032,GO:0019835,GO:0030881,GO:0032815,GO:0042267,GO:0042742,GO:0045953,GO:0046629,GO:0046703,GO:0050776,GO:0051607" T cell mediated cytotoxicity|immune response to tumor cell|protein binding|extracellular space|cytoplasm|plasma membrane|integral component of plasma membrane|immune response|cellular response to DNA damage stimulus|response to heat|external side of plasma membrane|cell surface|viral process|cytolysis|beta-2-microglobulin binding|negative regulation of natural killer cell activation|natural killer cell mediated cytotoxicity|defense response to bacterium|negative regulation of natural killer cell mediated cytotoxicity|gamma-delta T cell activation|natural killer cell lectin-like receptor binding|regulation of immune response|defense response to virus "hsa04650,hsa05167" Natural killer cell mediated cytotoxicity|Kaposi sarcoma-associated herpesvirus infection MICAL1 955.9502053 858.6527492 1053.247661 1.226628183 0.294698003 0.407115106 1 11.6433019 14.89721299 64780 "microtubule associated monooxygenase, calponin and LIM domain containing 1" "GO:0001933,GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005882,GO:0005886,GO:0007010,GO:0007165,GO:0007596,GO:0015629,GO:0016174,GO:0016709,GO:0017124,GO:0019417,GO:0019901,GO:0030042,GO:0030496,GO:0031267,GO:0043154,GO:0045171,GO:0046872,GO:0051015,GO:0051017,GO:0055114,GO:0071949,GO:1903305,GO:1990026" "negative regulation of protein phosphorylation|actin binding|protein binding|cytoplasm|cytosol|intermediate filament|plasma membrane|cytoskeleton organization|signal transduction|blood coagulation|actin cytoskeleton|NAD(P)H oxidase H2O2-forming activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|SH3 domain binding|sulfur oxidation|protein kinase binding|actin filament depolymerization|midbody|small GTPase binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|intercellular bridge|metal ion binding|actin filament binding|actin filament bundle assembly|oxidation-reduction process|FAD binding|regulation of regulated secretory pathway|hippocampal mossy fiber expansion" MICAL2 10059.89762 10599.18518 9520.610057 0.898239808 -0.154827435 0.645628094 1 70.56807382 66.11751024 9645 "microtubule associated monooxygenase, calponin and LIM domain containing 2" "GO:0001947,GO:0003779,GO:0005515,GO:0005634,GO:0007010,GO:0007507,GO:0010735,GO:0016491,GO:0016709,GO:0019417,GO:0030042,GO:0043914,GO:0046872,GO:0055114,GO:0071949" "heart looping|actin binding|protein binding|nucleus|cytoskeleton organization|heart development|positive regulation of transcription via serum response element binding|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|sulfur oxidation|actin filament depolymerization|NADPH:sulfur oxidoreductase activity|metal ion binding|oxidation-reduction process|FAD binding" MICAL3 2806.066471 2528.255317 3083.877624 1.219765109 0.286603354 0.368139862 1 8.664718681 11.02418781 57553 "microtubule associated monooxygenase, calponin and LIM domain containing 3" "GO:0003779,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005886,GO:0005938,GO:0006887,GO:0007010,GO:0007049,GO:0016709,GO:0030042,GO:0042995,GO:0045171,GO:0046872,GO:0051301,GO:0055114,GO:0071949,GO:0090543" "actin binding|nucleus|nucleoplasm|spindle|cytosol|plasma membrane|cell cortex|exocytosis|cytoskeleton organization|cell cycle|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|actin filament depolymerization|cell projection|intercellular bridge|metal ion binding|cell division|oxidation-reduction process|FAD binding|Flemming body" MICALCL 31.58512283 37.55337083 25.61687483 0.682145817 -0.551847929 0.583937646 1 0.314891681 0.224054844 84953 MICAL C-terminal like "GO:0005737,GO:0005815,GO:0007275,GO:0007283,GO:0008150,GO:0030036,GO:0030154,GO:0031941,GO:0051019" cytoplasm|microtubule organizing center|multicellular organism development|spermatogenesis|biological_process|actin cytoskeleton organization|cell differentiation|filamentous actin|mitogen-activated protein kinase binding MICALL1 1581.315991 1513.299349 1649.332633 1.089891854 0.124184989 0.707287142 1 15.34399868 17.44367108 85377 MICAL like 1 "GO:0005515,GO:0005769,GO:0005770,GO:0005802,GO:0006612,GO:0006897,GO:0006898,GO:0019898,GO:0031175,GO:0031267,GO:0031902,GO:0032458,GO:0036010,GO:0042802,GO:0045296,GO:0046872,GO:0055038,GO:0070300,GO:0097320,GO:1990126" "protein binding|early endosome|late endosome|trans-Golgi network|protein targeting to membrane|endocytosis|receptor-mediated endocytosis|extrinsic component of membrane|neuron projection development|small GTPase binding|late endosome membrane|slow endocytic recycling|protein localization to endosome|identical protein binding|cadherin binding|metal ion binding|recycling endosome membrane|phosphatidic acid binding|plasma membrane tubulation|retrograde transport, endosome to plasma membrane" MICALL2 185.8099333 208.0659735 163.5538931 0.786067469 -0.347274949 0.53256253 1 2.498294819 2.048422043 79778 MICAL like 2 "GO:0001725,GO:0005515,GO:0005829,GO:0005886,GO:0005911,GO:0005923,GO:0030041,GO:0031005,GO:0031175,GO:0031267,GO:0031532,GO:0032432,GO:0032456,GO:0034446,GO:0042805,GO:0043005,GO:0046872,GO:0051015,GO:0055037,GO:0070830,GO:1903955" stress fiber|protein binding|cytosol|plasma membrane|cell-cell junction|bicellular tight junction|actin filament polymerization|filamin binding|neuron projection development|small GTPase binding|actin cytoskeleton reorganization|actin filament bundle|endocytic recycling|substrate adhesion-dependent cell spreading|actinin binding|neuron projection|metal ion binding|actin filament binding|recycling endosome|bicellular tight junction assembly|positive regulation of protein targeting to mitochondrion hsa04530 Tight junction MICB 505.8830513 434.4011545 577.3649481 1.329105464 0.410455587 0.314102601 1 8.821526062 12.22979268 4277 MHC class I polypeptide-related sequence B "GO:0002250,GO:0002429,GO:0005615,GO:0005886,GO:0006955,GO:0006979,GO:0009408,GO:0009897,GO:0009986,GO:0016021,GO:0016032,GO:0019835,GO:0032526,GO:0046629,GO:0046703,GO:0050689,GO:0050776" adaptive immune response|immune response-activating cell surface receptor signaling pathway|extracellular space|plasma membrane|immune response|response to oxidative stress|response to heat|external side of plasma membrane|cell surface|integral component of membrane|viral process|cytolysis|response to retinoic acid|gamma-delta T cell activation|natural killer cell lectin-like receptor binding|negative regulation of defense response to virus by host|regulation of immune response "hsa04650,hsa05167" Natural killer cell mediated cytotoxicity|Kaposi sarcoma-associated herpesvirus infection MICOS10 258.7289027 276.0680234 241.3897821 0.874385157 -0.193659183 0.700841695 1 3.527212784 3.216994856 440574 mitochondrial contact site and cristae organizing system subunit 10 "GO:0001401,GO:0003674,GO:0005515,GO:0005739,GO:0007007,GO:0008150,GO:0061617,GO:0140275" SAM complex|molecular_function|protein binding|mitochondrion|inner mitochondrial membrane organization|biological_process|MICOS complex|MIB complex MICOS13 465.8083741 523.7172797 407.8994685 0.778854325 -0.360574579 0.386825244 1 26.52443265 21.54856077 125988 mitochondrial contact site and cristae organizing system subunit 13 "GO:0001401,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0007007,GO:0042407,GO:0044284,GO:0061617,GO:0140275" SAM complex|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|inner mitochondrial membrane organization|cristae formation|mitochondrial crista junction|MICOS complex|MIB complex MICU1 2577.309698 2482.582299 2672.037098 1.076313603 0.106098493 0.740029397 1 46.10709036 51.76336193 10367 mitochondrial calcium uptake 1 "GO:0005509,GO:0005515,GO:0005622,GO:0005739,GO:0005743,GO:0005758,GO:0006851,GO:0006952,GO:0032592,GO:0034704,GO:0036444,GO:0042802,GO:0046982,GO:0051260,GO:0051560,GO:0051561,GO:0070509,GO:1900069,GO:1990246" calcium ion binding|protein binding|intracellular anatomical structure|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial calcium ion transmembrane transport|defense response|integral component of mitochondrial membrane|calcium channel complex|calcium import into the mitochondrion|identical protein binding|protein heterodimerization activity|protein homooligomerization|mitochondrial calcium ion homeostasis|positive regulation of mitochondrial calcium ion concentration|calcium ion import|regulation of cellular hyperosmotic salinity response|uniplex complex MICU2 674.9165196 606.9436691 742.8893701 1.22398405 0.291584758 0.444484431 1 15.63558274 19.96207855 221154 mitochondrial calcium uptake 2 "GO:0005509,GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0006851,GO:0034704,GO:0036444,GO:0046982,GO:0051560,GO:0051561,GO:0051562,GO:1990246" calcium ion binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial calcium ion transmembrane transport|calcium channel complex|calcium import into the mitochondrion|protein heterodimerization activity|mitochondrial calcium ion homeostasis|positive regulation of mitochondrial calcium ion concentration|negative regulation of mitochondrial calcium ion concentration|uniplex complex MID1 379.9946142 416.131947 343.8572814 0.826317911 -0.275231155 0.53366547 1 2.663753171 2.295921718 4281 midline 1 "GO:0000226,GO:0005515,GO:0005819,GO:0005829,GO:0005874,GO:0005875,GO:0005881,GO:0007389,GO:0008017,GO:0008270,GO:0016740,GO:0019899,GO:0031625,GO:0032874,GO:0035372,GO:0042802,GO:0042803,GO:0051219,GO:0060333" microtubule cytoskeleton organization|protein binding|spindle|cytosol|microtubule|microtubule associated complex|cytoplasmic microtubule|pattern specification process|microtubule binding|zinc ion binding|transferase activity|enzyme binding|ubiquitin protein ligase binding|positive regulation of stress-activated MAPK cascade|protein localization to microtubule|identical protein binding|protein homodimerization activity|phosphoprotein binding|interferon-gamma-mediated signaling pathway hsa04120 Ubiquitin mediated proteolysis MID1IP1 1735.458654 1408.758884 2062.158424 1.463812188 0.549730462 0.092340176 1 18.98580832 28.98880951 58526 MID1 interacting protein 1 "GO:0005515,GO:0005634,GO:0005829,GO:0005874,GO:0006629,GO:0006853,GO:0007026,GO:0008022,GO:0015630,GO:0042802,GO:0045723,GO:0046890,GO:0051258,GO:0051351" protein binding|nucleus|cytosol|microtubule|lipid metabolic process|carnitine shuttle|negative regulation of microtubule depolymerization|protein C-terminus binding|microtubule cytoskeleton|identical protein binding|positive regulation of fatty acid biosynthetic process|regulation of lipid biosynthetic process|protein polymerization|positive regulation of ligase activity MID2 309.1258457 286.2175831 332.0341084 1.160075858 0.214219148 0.651112174 1 1.983296055 2.399881881 11043 midline 2 "GO:0003713,GO:0005737,GO:0005874,GO:0008017,GO:0008270,GO:0010508,GO:0016567,GO:0016740,GO:0019899,GO:0032897,GO:0035372,GO:0042803,GO:0043123,GO:0045087,GO:0045893,GO:0046597,GO:0051091,GO:0051092,GO:0051219,GO:0070062,GO:1902187" "transcription coactivator activity|cytoplasm|microtubule|microtubule binding|zinc ion binding|positive regulation of autophagy|protein ubiquitination|transferase activity|enzyme binding|negative regulation of viral transcription|protein localization to microtubule|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription, DNA-templated|negative regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|phosphoprotein binding|extracellular exosome|negative regulation of viral release from host cell" MIDEAS 1441.240935 1737.604618 1144.877252 0.658882487 -0.601906914 0.071318738 1 10.35214022 7.114658185 91748 mitotic deacetylase associated SANT domain protein "GO:0000118,GO:0003677,GO:0003714,GO:0005654,GO:0005667,GO:0006357,GO:0016575,GO:0045892" "histone deacetylase complex|DNA binding|transcription corepressor activity|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|histone deacetylation|negative regulation of transcription, DNA-templated" MIDN 804.1831126 755.1272405 853.2389847 1.129927433 0.176230122 0.632665201 1 9.743829503 11.48407867 90007 midnolin "GO:0003674,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0008150,GO:0019900,GO:0033132,GO:0046676" molecular_function|protein binding|nucleus|nucleolus|cytoplasm|cytosol|biological_process|kinase binding|negative regulation of glucokinase activity|negative regulation of insulin secretion MIEF1 734.6571449 818.0545105 651.2597793 0.796108048 -0.328963848 0.379278323 1 6.672825742 5.541122195 54471 mitochondrial elongation factor 1 "GO:0000266,GO:0005515,GO:0005739,GO:0005741,GO:0005777,GO:0008053,GO:0016021,GO:0019003,GO:0042802,GO:0043531,GO:0090141,GO:0090314" mitochondrial fission|protein binding|mitochondrion|mitochondrial outer membrane|peroxisome|mitochondrial fusion|integral component of membrane|GDP binding|identical protein binding|ADP binding|positive regulation of mitochondrial fission|positive regulation of protein targeting to membrane MIEF2 323.904812 286.2175831 361.5920409 1.263346706 0.337250619 0.466743942 1 4.115817964 5.423687274 125170 mitochondrial elongation factor 2 "GO:0003374,GO:0005515,GO:0005739,GO:0005741,GO:0005777,GO:0007005,GO:0008053,GO:0010821,GO:0016021,GO:0090141,GO:0090314" dynamin family protein polymerization involved in mitochondrial fission|protein binding|mitochondrion|mitochondrial outer membrane|peroxisome|mitochondrion organization|mitochondrial fusion|regulation of mitochondrion organization|integral component of membrane|positive regulation of mitochondrial fission|positive regulation of protein targeting to membrane MIEN1 754.397568 753.0973285 755.6978075 1.003453045 0.00497311 0.993392758 1 25.84127569 27.04748785 84299 migration and invasion enhancer 1 "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006915,GO:0010269,GO:0030335,GO:0031235,GO:0034451,GO:0043066,GO:0051491" protein binding|nucleoplasm|cytosol|plasma membrane|apoptotic process|response to selenium ion|positive regulation of cell migration|intrinsic component of the cytoplasmic side of the plasma membrane|centriolar satellite|negative regulation of apoptotic process|positive regulation of filopodium assembly MIER1 839.8577509 802.830171 876.8853307 1.092242622 0.12729336 0.728557276 1 6.593240789 7.511626512 57708 MIER1 transcriptional regulator "GO:0000122,GO:0001103,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016575,GO:0017053,GO:0031937,GO:0032991,GO:0042826,GO:0043123" negative regulation of transcription by RNA polymerase II|RNA polymerase II repressing transcription factor binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|histone deacetylation|transcription repressor complex|positive regulation of chromatin silencing|protein-containing complex|histone deacetylase binding|positive regulation of I-kappaB kinase/NF-kappaB signaling MIER2 449.1439943 394.8178717 503.4701169 1.275195864 0.350718855 0.40462382 1 2.872182184 3.820364573 54531 MIER family member 2 "GO:0000122,GO:0001103,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016575,GO:0032991,GO:0042826" negative regulation of transcription by RNA polymerase II|RNA polymerase II repressing transcription factor binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|histone deacetylation|protein-containing complex|histone deacetylase binding MIER3 803.3314602 764.2618442 842.4010761 1.102241441 0.140440274 0.704036714 1 7.262132505 8.349430107 166968 MIER family member 3 "GO:0000122,GO:0001103,GO:0003714,GO:0004407,GO:0005634,GO:0005654,GO:0016575,GO:0032991,GO:0042826" negative regulation of transcription by RNA polymerase II|RNA polymerase II repressing transcription factor binding|transcription corepressor activity|histone deacetylase activity|nucleus|nucleoplasm|histone deacetylation|protein-containing complex|histone deacetylase binding MIF 10648.60548 12284.01209 9013.198883 0.733734127 -0.446670707 0.187346232 1 1116.951305 854.8479777 4282 macrophage migration inhibitory factor "GO:0001516,GO:0001819,GO:0004167,GO:0005125,GO:0005126,GO:0005515,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007166,GO:0009986,GO:0010629,GO:0010739,GO:0010760,GO:0019752,GO:0030336,GO:0030890,GO:0031982,GO:0032760,GO:0033138,GO:0034774,GO:0035722,GO:0042056,GO:0042327,GO:0042802,GO:0043030,GO:0043066,GO:0043312,GO:0043518,GO:0045087,GO:0048146,GO:0050178,GO:0050731,GO:0050900,GO:0050918,GO:0070062,GO:0070207,GO:0070374,GO:0071157,GO:0090344,GO:1902166,GO:1904813" "prostaglandin biosynthetic process|positive regulation of cytokine production|dopachrome isomerase activity|cytokine activity|cytokine receptor binding|protein binding|extracellular region|extracellular space|nucleoplasm|cytoplasm|cytosol|plasma membrane|inflammatory response|cell surface receptor signaling pathway|cell surface|negative regulation of gene expression|positive regulation of protein kinase A signaling|negative regulation of macrophage chemotaxis|carboxylic acid metabolic process|negative regulation of cell migration|positive regulation of B cell proliferation|vesicle|positive regulation of tumor necrosis factor production|positive regulation of peptidyl-serine phosphorylation|secretory granule lumen|interleukin-12-mediated signaling pathway|chemoattractant activity|positive regulation of phosphorylation|identical protein binding|regulation of macrophage activation|negative regulation of apoptotic process|neutrophil degranulation|negative regulation of DNA damage response, signal transduction by p53 class mediator|innate immune response|positive regulation of fibroblast proliferation|phenylpyruvate tautomerase activity|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|positive chemotaxis|extracellular exosome|protein homotrimerization|positive regulation of ERK1 and ERK2 cascade|negative regulation of cell cycle arrest|negative regulation of cell aging|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|ficolin-1-rich granule lumen" "hsa00350,hsa00360" Tyrosine metabolism|Phenylalanine metabolism MIF4GD 419.6696932 467.8947014 371.444685 0.793863841 -0.333036508 0.43741142 1 9.303971729 7.704249398 57409 MIF4G domain containing "GO:0003723,GO:0005515,GO:0005730,GO:0005794,GO:0005829,GO:0006446,GO:0008022,GO:0008494,GO:0042802,GO:0045727" RNA binding|protein binding|nucleolus|Golgi apparatus|cytosol|regulation of translational initiation|protein C-terminus binding|translation activator activity|identical protein binding|positive regulation of translation MIGA1 694.6514995 608.973581 780.3294179 1.281384681 0.357703648 0.344765721 1 4.692281082 6.271616257 374986 mitoguardin 1 "GO:0005515,GO:0005739,GO:0005741,GO:0005887,GO:0008053,GO:0042803,GO:0046982" protein binding|mitochondrion|mitochondrial outer membrane|integral component of plasma membrane|mitochondrial fusion|protein homodimerization activity|protein heterodimerization activity MIGA2 703.9642525 639.4222601 768.5062449 1.201875963 0.265288014 0.482814891 1 8.719569662 10.93127025 84895 mitoguardin 2 "GO:0005515,GO:0005741,GO:0005887,GO:0008053,GO:0042803,GO:0046982,GO:0060348" protein binding|mitochondrial outer membrane|integral component of plasma membrane|mitochondrial fusion|protein homodimerization activity|protein heterodimerization activity|bone development MIIP 380.510257 316.6662621 444.3542519 1.403225746 0.488747123 0.266953337 1 8.305556212 12.15660193 60672 migration and invasion inhibitory protein "GO:0005515,GO:0010972,GO:0030336" protein binding|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of cell migration MILR1 30.71862462 45.67301858 15.76423066 0.345154123 -1.534687378 0.122013622 1 0.691532815 0.248967001 284021 mast cell immunoglobulin like receptor 1 "GO:0004888,GO:0005515,GO:0005887,GO:0007166,GO:0033004,GO:0043303,GO:0098742" transmembrane signaling receptor activity|protein binding|integral component of plasma membrane|cell surface receptor signaling pathway|negative regulation of mast cell activation|mast cell degranulation|cell-cell adhesion via plasma-membrane adhesion molecules MINAR1 89.17311066 101.4955968 76.85062449 0.757181857 -0.401288252 0.575009882 1 0.480006903 0.379108579 23251 membrane integral NOTCH2 associated receptor 1 "GO:0001525,GO:0005515,GO:0005886,GO:0008285,GO:0010977,GO:0016021,GO:0016525,GO:0030308,GO:0031397,GO:0032007" angiogenesis|protein binding|plasma membrane|negative regulation of cell population proliferation|negative regulation of neuron projection development|integral component of membrane|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of protein ubiquitination|negative regulation of TOR signaling MINDY1 270.9407875 268.9633316 272.9182434 1.014704279 0.021059335 0.973982184 1 3.373463076 3.570519279 55793 MINDY lysine 48 deubiquitinase 1 "GO:0004843,GO:0005515,GO:0005654,GO:0005829,GO:0008150,GO:0016604,GO:0016807,GO:0018215,GO:0036435,GO:0071108,GO:0071944,GO:1990380" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytosol|biological_process|nuclear body|cysteine-type carboxypeptidase activity|protein phosphopantetheinylation|K48-linked polyubiquitin modification-dependent protein binding|protein K48-linked deubiquitination|cell periphery|Lys48-specific deubiquitinase activity MINDY2 549.6664509 632.3175683 467.0153334 0.738577191 -0.437179385 0.273626565 1 3.425829498 2.639231985 54629 MINDY lysine 48 deubiquitinase 2 "GO:0004843,GO:0005654,GO:0005829,GO:0008150,GO:0016807,GO:0018215,GO:0036435,GO:0070530,GO:0071108,GO:0071795,GO:0071796,GO:0071944,GO:1990380" thiol-dependent ubiquitin-specific protease activity|nucleoplasm|cytosol|biological_process|cysteine-type carboxypeptidase activity|protein phosphopantetheinylation|K48-linked polyubiquitin modification-dependent protein binding|K63-linked polyubiquitin modification-dependent protein binding|protein K48-linked deubiquitination|K11-linked polyubiquitin modification-dependent protein binding|K6-linked polyubiquitin modification-dependent protein binding|cell periphery|Lys48-specific deubiquitinase activity MINDY3 484.8307567 477.0293051 492.6322083 1.032708479 0.046433057 0.915250555 1 2.900690533 3.124604617 80013 MINDY lysine 48 deubiquitinase 3 "GO:0004843,GO:0005515,GO:0005654,GO:0006915,GO:0008234,GO:0018215,GO:0031965,GO:0071108,GO:1990380" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|apoptotic process|cysteine-type peptidase activity|protein phosphopantetheinylation|nuclear membrane|protein K48-linked deubiquitination|Lys48-specific deubiquitinase activity MINDY4 77.87498303 70.03196182 85.71800424 1.22398405 0.291584758 0.702821494 1 1.297794295 1.656904772 84182 MINDY lysine 48 deubiquitinase 4 "GO:0004843,GO:0008234,GO:0018215,GO:0071108,GO:1990380" thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|protein phosphopantetheinylation|protein K48-linked deubiquitination|Lys48-specific deubiquitinase activity MINK1 3409.745799 2946.417176 3873.074421 1.314503069 0.394517511 0.215154248 1 28.35910978 38.88392779 50488 misshapen like kinase 1 "GO:0000165,GO:0001952,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0006468,GO:0007165,GO:0007254,GO:0007268,GO:0007275,GO:0014069,GO:0022407,GO:0030033,GO:0030334,GO:0030424,GO:0030425,GO:0031098,GO:0031532,GO:0032147,GO:0046330,GO:0046777,GO:0048812,GO:0048813,GO:0070062,GO:0106310,GO:0106311,GO:1900745,GO:2000311" MAPK cascade|regulation of cell-matrix adhesion|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|Golgi apparatus|cytosol|protein phosphorylation|signal transduction|JNK cascade|chemical synaptic transmission|multicellular organism development|postsynaptic density|regulation of cell-cell adhesion|microvillus assembly|regulation of cell migration|axon|dendrite|stress-activated protein kinase signaling cascade|actin cytoskeleton reorganization|activation of protein kinase activity|positive regulation of JNK cascade|protein autophosphorylation|neuron projection morphogenesis|dendrite morphogenesis|extracellular exosome|protein serine kinase activity|protein threonine kinase activity|positive regulation of p38MAPK cascade|regulation of AMPA receptor activity MINPP1 1554.438463 1595.510782 1513.366144 0.948515147 -0.076257283 0.818836166 1 27.70208862 27.40770773 9562 multiple inositol-polyphosphate phosphatase 1 "GO:0001503,GO:0003993,GO:0005515,GO:0005783,GO:0005788,GO:0006470,GO:0006797,GO:0030282,GO:0030351,GO:0034417,GO:0043647,GO:0051717,GO:0052745,GO:0052826,GO:0070062,GO:0101006" "ossification|acid phosphatase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein dephosphorylation|polyphosphate metabolic process|bone mineralization|inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity|bisphosphoglycerate 3-phosphatase activity|inositol phosphate metabolic process|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|inositol phosphate phosphatase activity|inositol hexakisphosphate 2-phosphatase activity|extracellular exosome|protein histidine phosphatase activity" "hsa00010,hsa00562" Glycolysis / Gluconeogenesis|Inositol phosphate metabolism MIOS 406.5494945 446.5806261 366.518363 0.820721593 -0.285035184 0.510712034 1 4.277181027 3.661587538 54468 meiosis regulator for oocyte development "GO:0005515,GO:0005654,GO:0005737,GO:0005765,GO:0005829,GO:0030054,GO:0032008,GO:0034198,GO:0034629,GO:0061700" protein binding|nucleoplasm|cytoplasm|lysosomal membrane|cytosol|cell junction|positive regulation of TOR signaling|cellular response to amino acid starvation|cellular protein-containing complex localization|GATOR2 complex hsa04150 mTOR signaling pathway MIOX 21.5246378 23.34398727 19.70528833 0.844126931 -0.244468142 0.860755948 1 0.305501448 0.26899051 55586 myo-inositol oxygenase "GO:0004033,GO:0005737,GO:0005829,GO:0008199,GO:0016234,GO:0016651,GO:0016701,GO:0019310,GO:0043647,GO:0050113,GO:0055114" "aldo-keto reductase (NADP) activity|cytoplasm|cytosol|ferric iron binding|inclusion body|oxidoreductase activity, acting on NAD(P)H|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen|inositol catabolic process|inositol phosphate metabolic process|inositol oxygenase activity|oxidation-reduction process" "hsa00053,hsa00562" Ascorbate and aldarate metabolism|Inositol phosphate metabolism MIPEP 299.8967242 328.8457338 270.9477146 0.823935623 -0.279396476 0.557247739 1 5.290621447 4.546905184 4285 mitochondrial intermediate peptidase "GO:0004222,GO:0005739,GO:0005759,GO:0006508,GO:0006518,GO:0006627,GO:0046872" metalloendopeptidase activity|mitochondrion|mitochondrial matrix|proteolysis|peptide metabolic process|protein processing involved in protein targeting to mitochondrion|metal ion binding MIPOL1 141.0006914 142.0938356 139.9075471 0.98461377 -0.022370179 0.983661672 1 0.301502011 0.309650687 145282 mirror-image polydactyly 1 "GO:0005515,GO:0005634,GO:0042802" protein binding|nucleus|identical protein binding MIS12 829.9875393 835.308762 824.6663166 0.987259268 -0.018499089 0.963129098 1 15.37820502 15.83626628 79003 MIS12 kinetochore complex component "GO:0000070,GO:0000444,GO:0000777,GO:0000818,GO:0005515,GO:0005634,GO:0005829,GO:0007059,GO:0034501,GO:0051301,GO:0051315,GO:0051382" mitotic sister chromatid segregation|MIS12/MIND type complex|condensed chromosome kinetochore|nuclear MIS12/MIND complex|protein binding|nucleus|cytosol|chromosome segregation|protein localization to kinetochore|cell division|attachment of mitotic spindle microtubules to kinetochore|kinetochore assembly MIS18A 288.4825519 255.768904 321.1961998 1.255806295 0.328613949 0.494517604 1 5.931223759 7.769317934 54069 MIS18 kinetochore protein A "GO:0000775,GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007049,GO:0007059,GO:0034080,GO:0042802,GO:0044030,GO:0046872,GO:0051301" "chromosome, centromeric region|chromatin|protein binding|nucleus|nucleoplasm|cytosol|cell cycle|chromosome segregation|CENP-A containing nucleosome assembly|identical protein binding|regulation of DNA methylation|metal ion binding|cell division" MIS18BP1 1537.636512 1322.487627 1752.785397 1.325369978 0.406395145 0.219046223 1 14.05947373 19.43668172 55320 MIS18 binding protein 1 "GO:0000778,GO:0003677,GO:0005515,GO:0005654,GO:0007049,GO:0034080,GO:0051301" condensed nuclear chromosome kinetochore|DNA binding|protein binding|nucleoplasm|cell cycle|CENP-A containing nucleosome assembly|cell division MISP 6.508139139 7.104691779 5.911586499 0.832067975 -0.265226703 0.975312627 1 0.112940231 0.098021966 126353 mitotic spindle positioning "GO:0000132,GO:0005515,GO:0005884,GO:0005886,GO:0005925,GO:0016477,GO:0030864,GO:0031616,GO:0043231,GO:0051015,GO:0051301,GO:0051640,GO:0051660,GO:0090307,GO:1904776,GO:1905721" establishment of mitotic spindle orientation|protein binding|actin filament|plasma membrane|focal adhesion|cell migration|cortical actin cytoskeleton|spindle pole centrosome|intracellular membrane-bounded organelle|actin filament binding|cell division|organelle localization|establishment of centrosome localization|mitotic spindle assembly|regulation of protein localization to cell cortex|mitotic spindle astral microtubule end MISP3 34.34792099 24.35894324 44.33689874 1.820148695 0.864056314 0.367624105 1 0.810042378 1.537908645 113230 MISP family member 3 MITD1 272.4632215 272.0081995 272.9182434 1.003345649 0.004818694 1 1 9.560205218 10.00538296 129531 microtubule interacting and trafficking domain containing 1 "GO:0000281,GO:0005515,GO:0019898,GO:0019904,GO:0030496,GO:0031902,GO:0032091,GO:0035091,GO:0039702,GO:0042802,GO:0043231,GO:0061952,GO:0070062,GO:0071985" mitotic cytokinesis|protein binding|extrinsic component of membrane|protein domain specific binding|midbody|late endosome membrane|negative regulation of protein binding|phosphatidylinositol binding|viral budding via host ESCRT complex|identical protein binding|intracellular membrane-bounded organelle|midbody abscission|extracellular exosome|multivesicular body sorting pathway MITF 87.57644783 93.37594909 81.77694657 0.875781691 -0.191356806 0.799754519 1 0.75197367 0.686933072 4286 melanocyte inducing transcription factor "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006355,GO:0006357,GO:0010628,GO:0030316,GO:0030318,GO:0030336,GO:0032991,GO:0042127,GO:0043010,GO:0044336,GO:0045165,GO:0045670,GO:0045893,GO:0045944,GO:0046849,GO:0046983,GO:0065003,GO:0070888,GO:2000144,GO:2001141" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of gene expression|osteoclast differentiation|melanocyte differentiation|negative regulation of cell migration|protein-containing complex|regulation of cell population proliferation|camera-type eye development|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|cell fate commitment|regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|bone remodeling|protein dimerization activity|protein-containing complex assembly|E-box binding|positive regulation of DNA-templated transcription, initiation|regulation of RNA biosynthetic process" "hsa04137,hsa04380,hsa04916,hsa05200,hsa05202,hsa05218" Mitophagy - animal|Osteoclast differentiation|Melanogenesis|Pathways in cancer|Transcriptional misregulation in cancer|Melanoma bHLH MIX23 279.9214903 344.0700733 215.7729072 0.627119078 -0.673188685 0.164078096 1 18.49886986 12.100718 131076 mitochondrial matrix import factor 23 GO:0005739 mitochondrion MKI67 9114.148928 8753.995227 9474.30263 1.082283276 0.114078158 0.732725529 1 33.51670517 37.8371308 4288 marker of proliferation Ki-67 "GO:0000793,GO:0003677,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0007049,GO:0007088,GO:0008022,GO:0008283,GO:0016020,GO:0016604,GO:0051983,GO:1902275" condensed chromosome|DNA binding|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|nucleolus|cell cycle|regulation of mitotic nuclear division|protein C-terminus binding|cell population proliferation|membrane|nuclear body|regulation of chromosome segregation|regulation of chromatin organization MKKS 1629.001354 1641.183801 1616.818908 0.985154074 -0.021578721 0.949565435 1 11.94942061 12.27911129 8195 McKusick-Kaufman syndrome "GO:0001103,GO:0001947,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0006457,GO:0007286,GO:0007368,GO:0007507,GO:0007601,GO:0007608,GO:0008406,GO:0010629,GO:0014824,GO:0021756,GO:0021766,GO:0021987,GO:0030837,GO:0031514,GO:0032402,GO:0032502,GO:0034260,GO:0035176,GO:0038108,GO:0040018,GO:0042311,GO:0045444,GO:0045494,GO:0045776,GO:0046907,GO:0048854,GO:0050910,GO:0051082,GO:0051131,GO:0051216,GO:0051492,GO:0051877,GO:0060027,GO:0060271,GO:0060296,GO:0060324,GO:1902636,GO:1905515" RNA polymerase II repressing transcription factor binding|heart looping|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|protein folding|spermatid development|determination of left/right symmetry|heart development|visual perception|sensory perception of smell|gonad development|negative regulation of gene expression|artery smooth muscle contraction|striatum development|hippocampus development|cerebral cortex development|negative regulation of actin filament polymerization|motile cilium|melanosome transport|developmental process|negative regulation of GTPase activity|social behavior|negative regulation of appetite by leptin-mediated signaling pathway|positive regulation of multicellular organism growth|vasodilation|fat cell differentiation|photoreceptor cell maintenance|negative regulation of blood pressure|intracellular transport|brain morphogenesis|detection of mechanical stimulus involved in sensory perception of sound|unfolded protein binding|chaperone-mediated protein complex assembly|cartilage development|regulation of stress fiber assembly|pigment granule aggregation in cell center|convergent extension involved in gastrulation|cilium assembly|regulation of cilium beat frequency involved in ciliary motility|face development|kinociliary basal body|non-motile cilium assembly MKLN1 2140.140056 2064.42044 2215.859673 1.073356779 0.102129701 0.751195067 1 9.064205672 10.14821792 4289 muskelin 1 "GO:0000151,GO:0001726,GO:0002090,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005938,GO:0007160,GO:0007165,GO:0008360,GO:0031532,GO:0042802,GO:0042803,GO:0098794" ubiquitin ligase complex|ruffle|regulation of receptor internalization|protein binding|nucleoplasm|cytoplasm|cytosol|cell cortex|cell-matrix adhesion|signal transduction|regulation of cell shape|actin cytoskeleton reorganization|identical protein binding|protein homodimerization activity|postsynapse MKNK1 804.821481 798.7703471 810.8726148 1.015151123 0.021694514 0.956488463 1 9.927582868 10.51211613 8569 MAPK interacting serine/threonine kinase 1 "GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006417,GO:0006468,GO:0009931,GO:0018105,GO:0035556,GO:0046777,GO:0046872,GO:0106310,GO:0106311" protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of translation|protein phosphorylation|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|intracellular signal transduction|protein autophosphorylation|metal ion binding|protein serine kinase activity|protein threonine kinase activity "hsa04010,hsa04066,hsa04910" MAPK signaling pathway|HIF-1 signaling pathway|Insulin signaling pathway MKNK2 1996.781362 2097.913987 1895.648737 0.903587444 -0.146263871 0.650629298 1 28.0718474 26.45800607 2872 MAPK interacting serine/threonine kinase 2 "GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006417,GO:0006468,GO:0007166,GO:0009931,GO:0016604,GO:0016605,GO:0018105,GO:0030097,GO:0035556,GO:0046777,GO:0046872,GO:0071243,GO:0097192,GO:0106310,GO:0106311" protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|regulation of translation|protein phosphorylation|cell surface receptor signaling pathway|calcium-dependent protein serine/threonine kinase activity|nuclear body|PML body|peptidyl-serine phosphorylation|hemopoiesis|intracellular signal transduction|protein autophosphorylation|metal ion binding|cellular response to arsenic-containing substance|extrinsic apoptotic signaling pathway in absence of ligand|protein serine kinase activity|protein threonine kinase activity "hsa04010,hsa04066,hsa04910" MAPK signaling pathway|HIF-1 signaling pathway|Insulin signaling pathway MKRN1 1930.728314 1859.399334 2002.057294 1.076722605 0.106646617 0.742333901 1 22.79642138 25.60273945 23608 makorin ring finger protein 1 "GO:0000209,GO:0003723,GO:0005515,GO:0005575,GO:0005829,GO:0016567,GO:0046872,GO:0061630" protein polyubiquitination|RNA binding|protein binding|cellular_component|cytosol|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity MKRN2 909.6549019 893.1612522 926.1485516 1.036933196 0.052322952 0.886816856 1 16.30106902 17.63123744 23609 makorin ring finger protein 2 "GO:0003723,GO:0005515,GO:0008150,GO:0016567,GO:0046872,GO:0061630" RNA binding|protein binding|biological_process|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity MKRN2OS 8.882225525 1.014955968 16.74949508 16.5026815 4.04462856 0.026535332 0.720384826 0.023071786 0.397147344 100129480 MKRN2 opposite strand MKS1 300.9440933 299.4120107 302.4761759 1.010233942 0.01468942 0.983096089 1 5.647732618 5.951302331 54903 MKS transition zone complex subunit 1 "GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0036038,GO:0036064,GO:0060271,GO:0097711" protein binding|cytoplasm|centrosome|cytosol|MKS complex|ciliary basal body|cilium assembly|ciliary basal body-plasma membrane docking MKX 103.877848 96.420817 111.3348791 1.154676786 0.207489073 0.76714198 1 1.091256811 1.314326704 283078 mohawk homeobox "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0007517,GO:0048468" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|muscle organ development|cell development" MLEC 7175.051064 7198.067728 7152.0344 0.993604766 -0.009256001 0.977953636 1 33.59350692 34.81648626 9761 malectin "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005975,GO:0006457,GO:0016020,GO:0016021,GO:0019899,GO:0030246,GO:0035579,GO:0043312" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|carbohydrate metabolic process|protein folding|membrane|integral component of membrane|enzyme binding|carbohydrate binding|specific granule membrane|neutrophil degranulation MLF1 370.7263985 388.7281359 352.7246611 0.907381351 -0.140219086 0.756084415 1 7.502937779 7.10128796 4291 myeloid leukemia factor 1 "GO:0002318,GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0005929,GO:0006351,GO:0006355,GO:0007050,GO:0019904,GO:0036064" "myeloid progenitor cell differentiation|DNA binding|protein binding|nucleus|cytoplasm|cilium|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle arrest|protein domain specific binding|ciliary basal body" hsa05202 Transcriptional misregulation in cancer MLF2 4141.644105 3912.655258 4370.632952 1.117050357 0.159694224 0.616850029 1 124.6303055 145.2152882 8079 myeloid leukemia factor 2 "GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0016020" "protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|membrane" MLH1 1606.286333 1570.136883 1642.435782 1.04604624 0.064946626 0.845029366 1 28.46166572 31.05468482 4292 mutL homolog 1 "GO:0000289,GO:0000712,GO:0000795,GO:0001673,GO:0003682,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005715,GO:0006298,GO:0006303,GO:0007060,GO:0007129,GO:0007283,GO:0008630,GO:0009617,GO:0016020,GO:0016321,GO:0016446,GO:0016887,GO:0019899,GO:0032137,GO:0032300,GO:0032389,GO:0032407,GO:0043060,GO:0045141,GO:0045190,GO:0045950,GO:0048298,GO:0048304,GO:0048477,GO:0051257" nuclear-transcribed mRNA poly(A) tail shortening|resolution of meiotic recombination intermediates|synaptonemal complex|male germ cell nucleus|chromatin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|late recombination nodule|mismatch repair|double-strand break repair via nonhomologous end joining|male meiosis chromosome segregation|homologous chromosome pairing at meiosis|spermatogenesis|intrinsic apoptotic signaling pathway in response to DNA damage|response to bacterium|membrane|female meiosis chromosome segregation|somatic hypermutation of immunoglobulin genes|ATPase activity|enzyme binding|guanine/thymine mispair binding|mismatch repair complex|MutLalpha complex|MutSalpha complex binding|meiotic metaphase I plate congression|meiotic telomere clustering|isotype switching|negative regulation of mitotic recombination|positive regulation of isotype switching to IgA isotypes|positive regulation of isotype switching to IgG isotypes|oogenesis|meiotic spindle midzone assembly "hsa01524,hsa03430,hsa03460,hsa05200,hsa05210,hsa05213,hsa05226" Platinum drug resistance|Mismatch repair|Fanconi anemia pathway|Pathways in cancer|Colorectal cancer|Endometrial cancer|Gastric cancer MLH3 588.3050472 579.5398579 597.0702364 1.030248788 0.042992767 0.917184004 1 3.747178515 4.026821934 27030 mutL homolog 3 "GO:0000795,GO:0001673,GO:0003682,GO:0003696,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005712,GO:0006298,GO:0007130,GO:0007131,GO:0007140,GO:0007144,GO:0008104,GO:0016887,GO:0019237,GO:0030983,GO:0032300" synaptonemal complex|male germ cell nucleus|chromatin binding|satellite DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|chiasma|mismatch repair|synaptonemal complex assembly|reciprocal meiotic recombination|male meiotic nuclear division|female meiosis I|protein localization|ATPase activity|centromeric DNA binding|mismatched DNA binding|mismatch repair complex hsa03430 Mismatch repair MLKL 341.4262874 338.9952934 343.8572814 1.014342346 0.020544652 0.971040977 1 6.533072949 6.91222703 197259 mixed lineage kinase domain like pseudokinase "GO:0004672,GO:0004706,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007166,GO:0007256,GO:0007257,GO:0019901,GO:0030054,GO:0044877,GO:0051607,GO:0070207,GO:0070266,GO:0097527,GO:0097528" protein kinase activity|JUN kinase kinase kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|cell surface receptor signaling pathway|activation of JNKK activity|activation of JUN kinase activity|protein kinase binding|cell junction|protein-containing complex binding|defense response to virus|protein homotrimerization|necroptotic process|necroptotic signaling pathway|execution phase of necroptosis "hsa04217,hsa04668,hsa05132" Necroptosis|TNF signaling pathway|Salmonella infection MLLT1 1324.530647 1201.707867 1447.353428 1.204413708 0.268331034 0.426328566 1 11.17148753 14.03468355 4298 MLLT1 super elongation complex subunit "GO:0001650,GO:0005515,GO:0005654,GO:0005829,GO:0006355,GO:0006366,GO:0006368,GO:0006469,GO:0008023" "fibrillar center|protein binding|nucleoplasm|cytosol|regulation of transcription, DNA-templated|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|negative regulation of protein kinase activity|transcription elongation factor complex" hsa05202 Transcriptional misregulation in cancer MLLT10 999.6257251 914.4753275 1084.776123 1.186227873 0.246381177 0.485105636 1 5.002154581 6.189294712 8028 MLLT10 histone lysine methyltransferase DOT1L cofactor "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0031491,GO:0032991,GO:0042393,GO:0045944,GO:0046872" DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|nucleosome binding|protein-containing complex|histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding MLLT11 1032.688498 1322.487627 742.8893701 0.561736348 -0.832034937 0.018065459 0.580235143 26.97516425 15.80565704 10962 MLLT11 transcription factor 7 cofactor "GO:0003674,GO:0005515,GO:0005654,GO:0005815,GO:0005829,GO:0043065,GO:0045893,GO:0051901,GO:0090200,GO:0097191,GO:0097193" "molecular_function|protein binding|nucleoplasm|microtubule organizing center|cytosol|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of mitochondrial depolarization|positive regulation of release of cytochrome c from mitochondria|extrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway" MLLT3 209.0230302 212.1257974 205.9202631 0.970745971 -0.042834281 0.945262738 1 1.549383228 1.568846224 4300 MLLT3 super elongation complex subunit "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006366,GO:0006368,GO:0007379,GO:0008023,GO:0009952,GO:0042393,GO:0045893,GO:0060218,GO:0070062,GO:0070577,GO:0090090,GO:0140030,GO:1902275,GO:2000035,GO:2000096" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|segment specification|transcription elongation factor complex|anterior/posterior pattern specification|histone binding|positive regulation of transcription, DNA-templated|hematopoietic stem cell differentiation|extracellular exosome|lysine-acetylated histone binding|negative regulation of canonical Wnt signaling pathway|modification-dependent protein binding|regulation of chromatin organization|regulation of stem cell division|positive regulation of Wnt signaling pathway, planar cell polarity pathway" hsa05202 Transcriptional misregulation in cancer MLLT6 3771.849523 2711.962347 4831.736699 1.781638563 0.83320469 0.009262335 0.405005328 17.52153663 32.56174905 4302 "MLLT6, PHD finger containing" "GO:0005515,GO:0005634,GO:0006355,GO:0010765,GO:0031491,GO:0035811,GO:0035812,GO:0036359,GO:0042393,GO:0045944,GO:0046872,GO:2001161" "protein binding|nucleus|regulation of transcription, DNA-templated|positive regulation of sodium ion transport|nucleosome binding|negative regulation of urine volume|renal sodium excretion|renal potassium excretion|histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of histone H3-K79 methylation" MLPH 143.3950667 70.03196182 216.7581716 3.09513208 1.630000975 0.007911935 0.364181927 0.654525154 2.113106849 79083 melanophilin "GO:0003779,GO:0005515,GO:0006886,GO:0017022,GO:0030425,GO:0030674,GO:0030864,GO:0031267,GO:0032402,GO:0046872,GO:0048471,GO:0070062" actin binding|protein binding|intracellular protein transport|myosin binding|dendrite|protein-macromolecule adaptor activity|cortical actin cytoskeleton|small GTPase binding|melanosome transport|metal ion binding|perinuclear region of cytoplasm|extracellular exosome MLST8 822.5332299 898.236032 746.8304277 0.831441182 -0.266313888 0.466721463 1 14.31031338 12.41070937 64223 "MTOR associated protein, LST8 homolog" "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007050,GO:0016241,GO:0031929,GO:0031931,GO:0031932,GO:0032008,GO:0032148,GO:0032956,GO:0038202,GO:0043539,GO:0071902,GO:1900034" protein binding|nucleoplasm|cytoplasm|cytosol|cell cycle arrest|regulation of macroautophagy|TOR signaling|TORC1 complex|TORC2 complex|positive regulation of TOR signaling|activation of protein kinase B activity|regulation of actin cytoskeleton organization|TORC1 signaling|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity|regulation of cellular response to heat "hsa04136,hsa04140,hsa04150,hsa04151,hsa04714" Autophagy - other|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Thermogenesis MLX 1176.028388 1152.98998 1199.066795 1.039962893 0.056532052 0.87137545 1 24.7435911 26.84086472 6945 MAX dimerization protein MLX "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0008134,GO:0031965,GO:0042803,GO:0045892,GO:0045944,GO:0046982,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription factor binding|nuclear membrane|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|sequence-specific double-stranded DNA binding" "hsa04931,hsa04932" Insulin resistance|Non-alcoholic fatty liver disease MLXIP 2143.62337 2369.922186 1917.324555 0.809024265 -0.305745121 0.340761767 1 13.82335577 11.66516706 22877 MLX interacting protein "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005634,GO:0005741,GO:0006357,GO:0045944,GO:0046983" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|mitochondrial outer membrane|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|protein dimerization activity" "hsa04931,hsa04932" Insulin resistance|Non-alcoholic fatty liver disease MLYCD 102.8628921 94.39090506 111.3348791 1.179508545 0.23818587 0.732558681 1 0.366214674 0.450560135 23417 malonyl-CoA decarboxylase "GO:0002931,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006085,GO:0006625,GO:0006633,GO:0006637,GO:0010906,GO:0019395,GO:0031998,GO:0042802,GO:0046321,GO:0050080,GO:2001294" response to ischemia|cytoplasm|mitochondrion|mitochondrial matrix|peroxisome|peroxisomal matrix|cytosol|acetyl-CoA biosynthetic process|protein targeting to peroxisome|fatty acid biosynthetic process|acyl-CoA metabolic process|regulation of glucose metabolic process|fatty acid oxidation|regulation of fatty acid beta-oxidation|identical protein binding|positive regulation of fatty acid oxidation|malonyl-CoA decarboxylase activity|malonyl-CoA catabolic process "hsa00410,hsa00640,hsa04146,hsa04152" beta-Alanine metabolism|Propanoate metabolism|Peroxisome|AMPK signaling pathway MMAA 55.27328455 74.09178569 36.45478341 0.49202193 -1.023205475 0.214876687 1 0.741451801 0.380525105 166785 metabolism of cobalamin associated A "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005759,GO:0009235,GO:0019626,GO:0042802,GO:0042803" GTPase activity|protein binding|GTP binding|cytoplasm|mitochondrion|mitochondrial matrix|cobalamin metabolic process|short-chain fatty acid catabolic process|identical protein binding|protein homodimerization activity MMAB 273.2136751 222.2753571 324.151993 1.458335271 0.544322433 0.264345984 1 1.973262523 3.001637048 326625 metabolism of cobalamin associated B "GO:0005515,GO:0005524,GO:0005759,GO:0008817,GO:0009235,GO:0031419" "protein binding|ATP binding|mitochondrial matrix|cob(I)yrinic acid a,c-diamide adenosyltransferase activity|cobalamin metabolic process|cobalamin binding" hsa00860 Porphyrin and chlorophyll metabolism MMACHC 378.7245584 430.3413306 327.1077863 0.760112411 -0.395715304 0.369746744 1 4.21490432 3.341807842 25974 metabolism of cobalamin associated C "GO:0005515,GO:0005737,GO:0005829,GO:0006749,GO:0009235,GO:0016491,GO:0016740,GO:0031419,GO:0032451,GO:0033787,GO:0042803,GO:0043295,GO:0055114,GO:0070988,GO:0071949" protein binding|cytoplasm|cytosol|glutathione metabolic process|cobalamin metabolic process|oxidoreductase activity|transferase activity|cobalamin binding|demethylase activity|cyanocobalamin reductase (cyanide-eliminating) activity|protein homodimerization activity|glutathione binding|oxidation-reduction process|demethylation|FAD binding hsa04977 Vitamin digestion and absorption MMADHC 1371.78004 1367.145689 1376.41439 1.0067796 0.009747889 0.979233725 1 49.74217397 52.23662371 27249 metabolism of cobalamin associated D "GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0009235" protein binding|cytoplasm|mitochondrion|cytosol|cobalamin metabolic process MMD 787.0394625 829.2190262 744.8598989 0.898266773 -0.154784125 0.676389367 1 15.74691352 14.75423538 23531 monocyte to macrophage differentiation associated "GO:0004672,GO:0005515,GO:0005765,GO:0005794,GO:0005887,GO:0006468,GO:0016020,GO:0019835,GO:0031902,GO:0032880,GO:0038023,GO:0045666,GO:0045860" protein kinase activity|protein binding|lysosomal membrane|Golgi apparatus|integral component of plasma membrane|protein phosphorylation|membrane|cytolysis|late endosome membrane|regulation of protein localization|signaling receptor activity|positive regulation of neuron differentiation|positive regulation of protein kinase activity MME 693.392084 859.6677052 527.1164629 0.613163039 -0.705657359 0.062754637 1 4.676096718 2.99071744 4311 membrane metalloendopeptidase "GO:0001786,GO:0001822,GO:0001890,GO:0002003,GO:0004175,GO:0004222,GO:0005515,GO:0005737,GO:0005769,GO:0005802,GO:0005886,GO:0005887,GO:0005903,GO:0005925,GO:0006508,GO:0006518,GO:0007568,GO:0007611,GO:0008021,GO:0008237,GO:0008238,GO:0008270,GO:0009986,GO:0016021,GO:0016485,GO:0019233,GO:0030324,GO:0030424,GO:0030425,GO:0030667,GO:0031410,GO:0042277,GO:0042803,GO:0043025,GO:0043312,GO:0044306,GO:0045121,GO:0045202,GO:0046449,GO:0050435,GO:0050769,GO:0061837,GO:0070012,GO:0070062,GO:0071345,GO:0071492,GO:0071493,GO:0090399,GO:0097242,GO:0098793,GO:0150094,GO:1900273,GO:1901612" phosphatidylserine binding|kidney development|placenta development|angiotensin maturation|endopeptidase activity|metalloendopeptidase activity|protein binding|cytoplasm|early endosome|trans-Golgi network|plasma membrane|integral component of plasma membrane|brush border|focal adhesion|proteolysis|peptide metabolic process|aging|learning or memory|synaptic vesicle|metallopeptidase activity|exopeptidase activity|zinc ion binding|cell surface|integral component of membrane|protein processing|sensory perception of pain|lung development|axon|dendrite|secretory granule membrane|cytoplasmic vesicle|peptide binding|protein homodimerization activity|neuronal cell body|neutrophil degranulation|neuron projection terminus|membrane raft|synapse|creatinine metabolic process|amyloid-beta metabolic process|positive regulation of neurogenesis|neuropeptide processing|oligopeptidase activity|extracellular exosome|cellular response to cytokine stimulus|cellular response to UV-A|cellular response to UV-B|replicative senescence|amyloid-beta clearance|presynapse|amyloid-beta clearance by cellular catabolic process|positive regulation of long-term synaptic potentiation|cardiolipin binding "hsa04614,hsa04640,hsa04974,hsa05010" Renin-angiotensin system|Hematopoietic cell lineage|Protein digestion and absorption|Alzheimer disease MMGT1 1243.460855 1317.412847 1169.508862 0.887731485 -0.17180473 0.614512763 1 12.96837962 12.00834807 93380 membrane magnesium transporter 1 "GO:0000139,GO:0005515,GO:0005769,GO:0005794,GO:0005886,GO:0006824,GO:0006825,GO:0015087,GO:0015093,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:0022890,GO:0030176,GO:0031901,GO:0032977,GO:0034755,GO:0045050,GO:0071816,GO:0072546,GO:1903830" Golgi membrane|protein binding|early endosome|Golgi apparatus|plasma membrane|cobalt ion transport|copper ion transport|cobalt ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|inorganic cation transmembrane transporter activity|integral component of endoplasmic reticulum membrane|early endosome membrane|membrane insertase activity|iron ion transmembrane transport|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex|magnesium ion transmembrane transport MMP1 64.54150025 101.4955968 27.58740366 0.271808872 -1.879335549 0.019280443 0.600752023 2.608013153 0.739416836 4312 matrix metallopeptidase 1 "GO:0004175,GO:0004222,GO:0004252,GO:0005576,GO:0006508,GO:0008233,GO:0008270,GO:0016032,GO:0019221,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0031334,GO:0044267,GO:0050900,GO:0071492" endopeptidase activity|metalloendopeptidase activity|serine-type endopeptidase activity|extracellular region|proteolysis|peptidase activity|zinc ion binding|viral process|cytokine-mediated signaling pathway|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|positive regulation of protein-containing complex assembly|cellular protein metabolic process|leukocyte migration|cellular response to UV-A "hsa03320,hsa04657,hsa04926,hsa05171,hsa05200,hsa05219,hsa05323" PPAR signaling pathway|IL-17 signaling pathway|Relaxin signaling pathway|Coronavirus disease - COVID-19|Pathways in cancer|Bladder cancer|Rheumatoid arthritis MMP10 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.087670164 0.029590485 4319 matrix metallopeptidase 10 "GO:0004222,GO:0005576,GO:0005615,GO:0006508,GO:0008270,GO:0022617,GO:0030198,GO:0030574,GO:0031012" metalloendopeptidase activity|extracellular region|extracellular space|proteolysis|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix MMP11 67.60393553 75.10674166 60.10112941 0.800209516 -0.321550309 0.68778542 1 1.682393412 1.40425895 4320 matrix metallopeptidase 11 "GO:0004222,GO:0005576,GO:0005796,GO:0006508,GO:0007275,GO:0008270,GO:0022617,GO:0030198,GO:0030199,GO:0030574,GO:0031012,GO:0045599,GO:0071711" metalloendopeptidase activity|extracellular region|Golgi lumen|proteolysis|multicellular organism development|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|collagen fibril organization|collagen catabolic process|extracellular matrix|negative regulation of fat cell differentiation|basement membrane organization MMP13 17.23940569 33.49354696 0.985264417 0.029416545 -5.087228401 0.001320804 0.108804729 0.625029475 0.019178211 4322 matrix metallopeptidase 13 "GO:0004175,GO:0004222,GO:0005509,GO:0005518,GO:0005576,GO:0005615,GO:0006508,GO:0008270,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0060349,GO:1904645" endopeptidase activity|metalloendopeptidase activity|calcium ion binding|collagen binding|extracellular region|extracellular space|proteolysis|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|bone morphogenesis|response to amyloid-beta "hsa04657,hsa04926,hsa04928" "IL-17 signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action" MMP14 11669.68112 11936.89714 11402.46509 0.955228562 -0.06608212 0.846589387 1 163.3509131 162.7589187 4323 matrix metallopeptidase 14 "GO:0001501,GO:0001525,GO:0001541,GO:0001666,GO:0001935,GO:0001958,GO:0004175,GO:0004222,GO:0005178,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005796,GO:0005829,GO:0005886,GO:0005887,GO:0005925,GO:0006508,GO:0006979,GO:0008270,GO:0008584,GO:0009612,GO:0010831,GO:0010954,GO:0014070,GO:0016485,GO:0022617,GO:0030198,GO:0030307,GO:0030324,GO:0030335,GO:0030574,GO:0031012,GO:0031410,GO:0031638,GO:0035987,GO:0035988,GO:0042470,GO:0043615,GO:0043627,GO:0044354,GO:0045111,GO:0045579,GO:0045746,GO:0048701,GO:0048754,GO:0048771,GO:0048870,GO:0051895,GO:0060322,GO:0070006,GO:0097094,GO:1903076,GO:1905523,GO:1990834" skeletal system development|angiogenesis|ovarian follicle development|response to hypoxia|endothelial cell proliferation|endochondral ossification|endopeptidase activity|metalloendopeptidase activity|integrin binding|protein binding|extracellular space|nucleus|cytoplasm|Golgi lumen|cytosol|plasma membrane|integral component of plasma membrane|focal adhesion|proteolysis|response to oxidative stress|zinc ion binding|male gonad development|response to mechanical stimulus|positive regulation of myotube differentiation|positive regulation of protein processing|response to organic cyclic compound|protein processing|extracellular matrix disassembly|extracellular matrix organization|positive regulation of cell growth|lung development|positive regulation of cell migration|collagen catabolic process|extracellular matrix|cytoplasmic vesicle|zymogen activation|endodermal cell differentiation|chondrocyte proliferation|melanosome|astrocyte cell migration|response to estrogen|macropinosome|intermediate filament cytoskeleton|positive regulation of B cell differentiation|negative regulation of Notch signaling pathway|embryonic cranial skeleton morphogenesis|branching morphogenesis of an epithelial tube|tissue remodeling|cell motility|negative regulation of focal adhesion assembly|head development|metalloaminopeptidase activity|craniofacial suture morphogenesis|regulation of protein localization to plasma membrane|positive regulation of macrophage migration|response to odorant "hsa04668,hsa04912,hsa04928" "TNF signaling pathway|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action" MMP15 289.4744973 357.2645009 221.6844937 0.620505237 -0.688484709 0.150360571 1 4.454501875 2.883105449 4324 matrix metallopeptidase 15 "GO:0004222,GO:0005515,GO:0005886,GO:0005887,GO:0006464,GO:0006508,GO:0008047,GO:0008270,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0032355,GO:0035987,GO:0050790,GO:0070006" metalloendopeptidase activity|protein binding|plasma membrane|integral component of plasma membrane|cellular protein modification process|proteolysis|enzyme activator activity|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|response to estradiol|endodermal cell differentiation|regulation of catalytic activity|metalloaminopeptidase activity hsa04928 "Parathyroid hormone synthesis, secretion and action" MMP16 511.8201239 671.9008511 351.7393967 0.52349896 -0.933741424 0.02216131 0.64869087 1.697481308 0.926908263 4325 matrix metallopeptidase 16 "GO:0001501,GO:0001958,GO:0004222,GO:0005796,GO:0005886,GO:0005887,GO:0006508,GO:0008047,GO:0008270,GO:0009986,GO:0016485,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0035988,GO:0048701,GO:0050790,GO:0070006,GO:0097094" skeletal system development|endochondral ossification|metalloendopeptidase activity|Golgi lumen|plasma membrane|integral component of plasma membrane|proteolysis|enzyme activator activity|zinc ion binding|cell surface|protein processing|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|chondrocyte proliferation|embryonic cranial skeleton morphogenesis|regulation of catalytic activity|metalloaminopeptidase activity|craniofacial suture morphogenesis "hsa04928,hsa05206" "Parathyroid hormone synthesis, secretion and action|MicroRNAs in cancer" MMP17 428.736749 582.5847258 274.8887722 0.471843425 -1.083619896 0.011446004 0.463101897 9.502692795 4.676926304 4326 matrix metallopeptidase 17 "GO:0004222,GO:0005886,GO:0006508,GO:0008047,GO:0008270,GO:0030198,GO:0030574,GO:0031012,GO:0031225,GO:0050790,GO:0070006" metalloendopeptidase activity|plasma membrane|proteolysis|enzyme activator activity|zinc ion binding|extracellular matrix organization|collagen catabolic process|extracellular matrix|anchored component of membrane|regulation of catalytic activity|metalloaminopeptidase activity hsa04928 "Parathyroid hormone synthesis, secretion and action" MMP19 78.889939 72.06187375 85.71800424 1.189505626 0.250362095 0.744680037 1 1.081386574 1.341724664 4327 matrix metallopeptidase 19 "GO:0001525,GO:0001541,GO:0001542,GO:0001554,GO:0004222,GO:0005576,GO:0005615,GO:0006508,GO:0008270,GO:0009725,GO:0022617,GO:0030154,GO:0030198,GO:0030574,GO:0031012,GO:0051591" angiogenesis|ovarian follicle development|ovulation from ovarian follicle|luteolysis|metalloendopeptidase activity|extracellular region|extracellular space|proteolysis|zinc ion binding|response to hormone|extracellular matrix disassembly|cell differentiation|extracellular matrix organization|collagen catabolic process|extracellular matrix|response to cAMP MMP24 21.34648849 11.16451565 31.52846133 2.823988278 1.4977341 0.176306893 1 0.123029446 0.362399747 10893 matrix metallopeptidase 24 "GO:0004222,GO:0005887,GO:0006508,GO:0008047,GO:0008270,GO:0010001,GO:0030198,GO:0030574,GO:0031012,GO:0032588,GO:0044331,GO:0045296,GO:0050790,GO:0050965,GO:0070062,GO:0097150,GO:0098742" metalloendopeptidase activity|integral component of plasma membrane|proteolysis|enzyme activator activity|zinc ion binding|glial cell differentiation|extracellular matrix organization|collagen catabolic process|extracellular matrix|trans-Golgi network membrane|cell-cell adhesion mediated by cadherin|cadherin binding|regulation of catalytic activity|detection of temperature stimulus involved in sensory perception of pain|extracellular exosome|neuronal stem cell population maintenance|cell-cell adhesion via plasma-membrane adhesion molecules hsa04928 "Parathyroid hormone synthesis, secretion and action" MMP24-AS1-EDEM2 7.523095107 9.134603715 5.911586499 0.64716398 -0.627796782 0.748279434 1 0.195783095 0.132161651 111089941 MMP24-AS1-EDEM2 readthrough "GO:0004571,GO:0005509,GO:0005783,GO:0005788,GO:0005975,GO:0006986,GO:0016020,GO:0036509,GO:0036510,GO:0036511,GO:0036512,GO:0044322,GO:0097466,GO:1904154,GO:1904382" "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum lumen|carbohydrate metabolic process|response to unfolded protein|membrane|trimming of terminal mannose on B branch|trimming of terminal mannose on C branch|trimming of first mannose on A branch|trimming of second mannose on A branch|endoplasmic reticulum quality control compartment|ubiquitin-dependent glycoprotein ERAD pathway|positive regulation of retrograde protein transport, ER to cytosol|mannose trimming involved in glycoprotein ERAD pathway" hsa04141 Protein processing in endoplasmic reticulum MMP24OS 425.7351807 411.0571672 440.4131942 1.071415923 0.099518642 0.819936882 1 12.28235717 13.72637149 101410538 MMP24 opposite strand MMP25 8.015727316 9.134603715 6.896850916 0.755024644 -0.405404361 0.864587159 1 0.087405149 0.068835754 64386 matrix metallopeptidase 25 "GO:0004222,GO:0005515,GO:0005886,GO:0006508,GO:0006954,GO:0008270,GO:0016020,GO:0030198,GO:0030574,GO:0031012,GO:0031225,GO:0035579,GO:0043312,GO:0060022" metalloendopeptidase activity|protein binding|plasma membrane|proteolysis|inflammatory response|zinc ion binding|membrane|extracellular matrix organization|collagen catabolic process|extracellular matrix|anchored component of membrane|specific granule membrane|neutrophil degranulation|hard palate development hsa04928 "Parathyroid hormone synthesis, secretion and action" MMP3 15.1798022 27.40381115 2.95579325 0.107860663 -3.212759283 0.018250222 0.584783716 0.761748825 0.085701971 4314 matrix metallopeptidase 3 "GO:0004175,GO:0004222,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0008233,GO:0008237,GO:0008270,GO:0010727,GO:0019221,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0031334,GO:0071492,GO:0071732,GO:0150077,GO:1903209,GO:1904645" endopeptidase activity|metalloendopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|proteolysis|peptidase activity|metallopeptidase activity|zinc ion binding|negative regulation of hydrogen peroxide metabolic process|cytokine-mediated signaling pathway|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|positive regulation of protein-containing complex assembly|cellular response to UV-A|cellular response to nitric oxide|regulation of neuroinflammatory response|positive regulation of oxidative stress-induced cell death|response to amyloid-beta "hsa04657,hsa04668,hsa05171,hsa05202,hsa05215,hsa05323" IL-17 signaling pathway|TNF signaling pathway|Coronavirus disease - COVID-19|Transcriptional misregulation in cancer|Prostate cancer|Rheumatoid arthritis MMP9 3.552345889 7.104691779 0 0 #NAME? 0.089820349 1 0.154035777 0 4318 matrix metallopeptidase 9 "GO:0001501,GO:0001503,GO:0001934,GO:0004175,GO:0004222,GO:0004252,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0006508,GO:0007566,GO:0008233,GO:0008237,GO:0008270,GO:0019221,GO:0022617,GO:0030198,GO:0030225,GO:0030335,GO:0030574,GO:0034614,GO:0035987,GO:0042802,GO:0043065,GO:0043066,GO:0043312,GO:0043388,GO:0045742,GO:0048013,GO:0050900,GO:0051549,GO:0062023,GO:0070062,GO:0071276,GO:0071492,GO:0090200,GO:0150077,GO:1900122,GO:1904645,GO:1904707,GO:1904724,GO:1904813,GO:2000697,GO:2001243,GO:2001258,GO:2001268" skeletal system development|ossification|positive regulation of protein phosphorylation|endopeptidase activity|metalloendopeptidase activity|serine-type endopeptidase activity|protein binding|collagen binding|extracellular region|extracellular space|proteolysis|embryo implantation|peptidase activity|metallopeptidase activity|zinc ion binding|cytokine-mediated signaling pathway|extracellular matrix disassembly|extracellular matrix organization|macrophage differentiation|positive regulation of cell migration|collagen catabolic process|cellular response to reactive oxygen species|endodermal cell differentiation|identical protein binding|positive regulation of apoptotic process|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of DNA binding|positive regulation of epidermal growth factor receptor signaling pathway|ephrin receptor signaling pathway|leukocyte migration|positive regulation of keratinocyte migration|collagen-containing extracellular matrix|extracellular exosome|cellular response to cadmium ion|cellular response to UV-A|positive regulation of release of cytochrome c from mitochondria|regulation of neuroinflammatory response|positive regulation of receptor binding|response to amyloid-beta|positive regulation of vascular associated smooth muscle cell proliferation|tertiary granule lumen|ficolin-1-rich granule lumen|negative regulation of epithelial cell differentiation involved in kidney development|negative regulation of intrinsic apoptotic signaling pathway|negative regulation of cation channel activity|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway "hsa01522,hsa04657,hsa04668,hsa04670,hsa04915,hsa04926,hsa05161,hsa05200,hsa05202,hsa05205,hsa05206,hsa05215,hsa05219,hsa05418" Endocrine resistance|IL-17 signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Estrogen signaling pathway|Relaxin signaling pathway|Hepatitis B|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Prostate cancer|Bladder cancer|Fluid shear stress and atherosclerosis MMRN2 7.434020452 3.044867905 11.823173 3.882983882 1.957165719 0.236388736 1 0.036551746 0.148043604 79812 multimerin 2 "GO:0002042,GO:0005201,GO:0005515,GO:0005604,GO:0005615,GO:0030948,GO:0062023,GO:0070062,GO:0090051" cell migration involved in sprouting angiogenesis|extracellular matrix structural constituent|protein binding|basement membrane|extracellular space|negative regulation of vascular endothelial growth factor receptor signaling pathway|collagen-containing extracellular matrix|extracellular exosome|negative regulation of cell migration involved in sprouting angiogenesis MMS19 4504.319641 4357.205972 4651.433311 1.067526608 0.094272029 0.768537654 1 52.15719953 58.07763232 64210 "MMS19 homolog, cytosolic iron-sulfur assembly component" "GO:0000160,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005675,GO:0005737,GO:0005815,GO:0005819,GO:0005829,GO:0006259,GO:0006281,GO:0006289,GO:0006351,GO:0006974,GO:0007059,GO:0009725,GO:0016020,GO:0016226,GO:0019899,GO:0030159,GO:0030331,GO:0030674,GO:0045893,GO:0071817,GO:0097361,GO:0097428,GO:1905168" "phosphorelay signal transduction system|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription factor TFIIH holo complex|cytoplasm|microtubule organizing center|spindle|cytosol|DNA metabolic process|DNA repair|nucleotide-excision repair|transcription, DNA-templated|cellular response to DNA damage stimulus|chromosome segregation|response to hormone|membrane|iron-sulfur cluster assembly|enzyme binding|signaling receptor complex adaptor activity|estrogen receptor binding|protein-macromolecule adaptor activity|positive regulation of transcription, DNA-templated|MMXD complex|CIA complex|protein maturation by iron-sulfur cluster transfer|positive regulation of double-strand break repair via homologous recombination" MMS22L 681.7539874 602.8838452 760.6241296 1.261642911 0.335303635 0.377877698 1 2.443301585 3.215358917 253714 "MMS22 like, DNA repair protein" "GO:0000724,GO:0005515,GO:0005654,GO:0005829,GO:0031297,GO:0035101,GO:0042555,GO:0043596" double-strand break repair via homologous recombination|protein binding|nucleoplasm|cytosol|replication fork processing|FACT complex|MCM complex|nuclear replication fork MMUT 659.5706922 601.8688892 717.2724952 1.191742102 0.253072064 0.509479438 1 7.905221985 9.826803729 4594 methylmalonyl-CoA mutase "GO:0003924,GO:0004494,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0009235,GO:0009791,GO:0019626,GO:0031419,GO:0042802,GO:0042803,GO:0043547,GO:0046872,GO:0050667,GO:0072341" GTPase activity|methylmalonyl-CoA mutase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|cobalamin metabolic process|post-embryonic development|short-chain fatty acid catabolic process|cobalamin binding|identical protein binding|protein homodimerization activity|positive regulation of GTPase activity|metal ion binding|homocysteine metabolic process|modified amino acid binding "hsa00280,hsa00630,hsa00640" "Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism" MN1 103.9466337 168.4826908 39.41057666 0.233914692 -2.095945618 0.002551956 0.16471056 1.092021233 0.266443121 4330 "MN1 proto-oncogene, transcriptional regulator" "GO:0001957,GO:0003674,GO:0005515,GO:0005634,GO:0006355,GO:0007275,GO:0033689,GO:0070564,GO:1902806" "intramembranous ossification|molecular_function|protein binding|nucleus|regulation of transcription, DNA-templated|multicellular organism development|negative regulation of osteoblast proliferation|positive regulation of vitamin D receptor signaling pathway|regulation of cell cycle G1/S phase transition" MNAT1 796.5857886 740.9178569 852.2537203 1.150267486 0.201969388 0.584117415 1 10.69999306 12.83802655 4331 MNAT1 component of CDK activating kinase "GO:0000079,GO:0000082,GO:0000086,GO:0000439,GO:0005515,GO:0005654,GO:0005675,GO:0006281,GO:0006283,GO:0006294,GO:0006357,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0007512,GO:0008270,GO:0019907,GO:0021591,GO:0043066,GO:0045737,GO:0047485,GO:0048661,GO:0051592,GO:0061575,GO:0065003,GO:0070516,GO:0070985,GO:1905775" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|transcription factor TFIIH core complex|protein binding|nucleoplasm|transcription factor TFIIH holo complex|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|adult heart development|zinc ion binding|cyclin-dependent protein kinase activating kinase holoenzyme complex|ventricular system development|negative regulation of apoptotic process|positive regulation of cyclin-dependent protein serine/threonine kinase activity|protein N-terminus binding|positive regulation of smooth muscle cell proliferation|response to calcium ion|cyclin-dependent protein serine/threonine kinase activator activity|protein-containing complex assembly|CAK-ERCC2 complex|transcription factor TFIIK complex|negative regulation of DNA helicase activity" "hsa03022,hsa03420" Basal transcription factors|Nucleotide excision repair MND1 182.0227766 151.2284393 212.817114 1.407255904 0.4928847 0.376672118 1 5.435902731 7.979224529 84057 meiotic nuclear divisions 1 "GO:0003690,GO:0005634,GO:0007131" double-stranded DNA binding|nucleus|reciprocal meiotic recombination MNS1 50.3942214 43.64310664 57.14533616 1.309378286 0.388881959 0.658481047 1 1.088851915 1.487133249 55329 meiosis specific nuclear structural 1 "GO:0005515,GO:0005635,GO:0005882,GO:0005930,GO:0007283,GO:0031514,GO:0036126,GO:0042802,GO:0044782,GO:0045724,GO:0051321,GO:0070986" protein binding|nuclear envelope|intermediate filament|axoneme|spermatogenesis|motile cilium|sperm flagellum|identical protein binding|cilium organization|positive regulation of cilium assembly|meiotic cell cycle|left/right axis specification MNT 760.1146756 941.8791387 578.3502125 0.614038669 -0.703598583 0.05853493 1 5.196955619 3.328592722 4335 MAX network transcriptional repressor "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003682,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0006366,GO:0007275,GO:0007569,GO:0008285,GO:0046983,GO:0051726,GO:2001234" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|multicellular organism development|cell aging|negative regulation of cell population proliferation|protein dimerization activity|regulation of cell cycle|negative regulation of apoptotic signaling pathway" bHLH MNX1 115.8643246 107.5853326 124.1433165 1.153905588 0.206525188 0.758630984 1 2.077322745 2.50028884 3110 motor neuron and pancreas homeobox 1 "GO:0000785,GO:0000981,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0007417,GO:0021520,GO:0031018,GO:0048812,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|central nervous system development|spinal cord motor neuron cell fate specification|endocrine pancreas development|neuron projection morphogenesis|sequence-specific double-stranded DNA binding" hsa04950 Maturity onset diabetes of the young MOAP1 732.3924222 764.2618442 700.5230002 0.916600777 -0.125634586 0.739403163 1 16.08108278 15.3748695 64112 modulator of apoptosis 1 "GO:0001844,GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0008625,GO:0008630,GO:0031625,GO:0042981,GO:0043065,GO:0090200,GO:0097190,GO:0097192" protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|protein binding|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|ubiquitin protein ligase binding|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of release of cytochrome c from mitochondria|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand MOB1A 2764.007656 2785.039177 2742.976136 0.984896786 -0.021955552 0.946206421 1 27.85945275 28.62063278 55233 MOB kinase activator 1A "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0035329,GO:0046872,GO:0070062" protein binding|nucleoplasm|nucleolus|cytosol|hippo signaling|metal ion binding|extracellular exosome "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species MOB1B 887.3461595 782.5310516 992.1612675 1.267887409 0.342426637 0.341868774 1 5.298454166 7.007220769 92597 MOB kinase activator 1B "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0019209,GO:0019900,GO:0031952,GO:0033674,GO:0035329,GO:0046872,GO:0070062" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|kinase activator activity|kinase binding|regulation of protein autophosphorylation|positive regulation of kinase activity|hippo signaling|metal ion binding|extracellular exosome "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species MOB2 450.6340151 429.3263746 471.9416555 1.099260803 0.136533711 0.748631083 1 12.39673107 14.21424682 81532 MOB kinase activator 2 "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0046872,GO:0048471" protein binding|nucleoplasm|nucleolus|cytosol|metal ion binding|perinuclear region of cytoplasm MOB3A 1387.909725 1829.965611 945.8538399 0.516869735 -0.952127367 0.004740642 0.257018659 25.20568465 13.58925134 126308 MOB kinase activator 3A GO:0046872 metal ion binding MOB3B 6.030352707 8.119647747 3.941057666 0.485372985 -1.042834281 0.589955466 1 0.063393173 0.032094752 79817 MOB kinase activator 3B "GO:0005515,GO:0035330,GO:0046872" protein binding|regulation of hippo signaling|metal ion binding MOB3C 509.7026211 459.7750537 559.6301886 1.217182586 0.283545598 0.486875615 1 7.800999826 9.904257617 148932 MOB kinase activator 3C "GO:0005515,GO:0046872" protein binding|metal ion binding MOCOS 622.9634917 456.7301858 789.1967977 1.727927828 0.78904296 0.042398842 0.940614529 3.741794348 6.744060277 55034 molybdenum cofactor sulfurase "GO:0005515,GO:0005575,GO:0005829,GO:0006777,GO:0008265,GO:0016829,GO:0030151,GO:0030170,GO:0032324,GO:0043545,GO:0102867" protein binding|cellular_component|cytosol|Mo-molybdopterin cofactor biosynthetic process|Mo-molybdopterin cofactor sulfurase activity|lyase activity|molybdenum ion binding|pyridoxal phosphate binding|molybdopterin cofactor biosynthetic process|molybdopterin cofactor metabolic process|molybdenum cofactor sulfurtransferase activity hsa00790 Folate biosynthesis MOCS1 184.797699 172.5425146 197.0528833 1.142054083 0.191630972 0.735633981 1 1.892715978 2.254696284 4337 molybdenum cofactor synthesis 1 "GO:0005525,GO:0005634,GO:0005829,GO:0006777,GO:0019008,GO:0032324,GO:0046872,GO:0051539,GO:0061798,GO:0061799" "GTP binding|nucleus|cytosol|Mo-molybdopterin cofactor biosynthetic process|molybdopterin synthase complex|molybdopterin cofactor biosynthetic process|metal ion binding|4 iron, 4 sulfur cluster binding|GTP 3',8'-cyclase activity|cyclic pyranopterin monophosphate synthase activity" hsa00790 Folate biosynthesis MOCS2 647.148245 628.2577444 666.0387456 1.060136149 0.084249556 0.829838394 1 7.637791261 8.445888782 4338 molybdenum cofactor synthesis 2 "GO:0005654,GO:0005829,GO:0006777,GO:0016607,GO:0019008,GO:0030366,GO:0032324" nucleoplasm|cytosol|Mo-molybdopterin cofactor biosynthetic process|nuclear speck|molybdopterin synthase complex|molybdopterin synthase activity|molybdopterin cofactor biosynthetic process "hsa00790,hsa04122" Folate biosynthesis|Sulfur relay system MOCS3 419.9963003 490.2237327 349.7688679 0.713488239 -0.487038446 0.255133007 1 4.856827593 3.61455998 27304 molybdenum cofactor synthesis 3 "GO:0002098,GO:0002143,GO:0004792,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006777,GO:0016779,GO:0016783,GO:0018215,GO:0032324,GO:0032447,GO:0034227,GO:0042292,GO:0046872,GO:0061604,GO:0061605" tRNA wobble uridine modification|tRNA wobble position uridine thiolation|thiosulfate sulfurtransferase activity|protein binding|ATP binding|cytoplasm|cytosol|Mo-molybdopterin cofactor biosynthetic process|nucleotidyltransferase activity|sulfurtransferase activity|protein phosphopantetheinylation|molybdopterin cofactor biosynthetic process|protein urmylation|tRNA thio-modification|URM1 activating enzyme activity|metal ion binding|molybdopterin-synthase sulfurtransferase activity|molybdopterin-synthase adenylyltransferase activity hsa04122 Sulfur relay system MOGS 1469.036426 1381.355073 1556.717778 1.126949767 0.17242321 0.604741618 1 24.40207929 28.6845025 7841 mannosyl-oligosaccharide glucosidase "GO:0004573,GO:0005783,GO:0005789,GO:0006457,GO:0006487,GO:0009311,GO:0015926,GO:0016020,GO:0016021,GO:0070062" mannosyl-oligosaccharide glucosidase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|protein N-linked glycosylation|oligosaccharide metabolic process|glucosidase activity|membrane|integral component of membrane|extracellular exosome "hsa00510,hsa04141" N-Glycan biosynthesis|Protein processing in endoplasmic reticulum MOK 274.2313526 190.8117221 357.6509832 1.87436589 0.906402605 0.063420626 1 2.300938233 4.498578078 5891 MOK protein kinase "GO:0000165,GO:0004672,GO:0004674,GO:0004693,GO:0004707,GO:0005524,GO:0005634,GO:0005737,GO:0005929,GO:0006468,GO:0007165,GO:0010468,GO:0035556,GO:0046872,GO:0051726,GO:0097546" MAPK cascade|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|MAP kinase activity|ATP binding|nucleus|cytoplasm|cilium|protein phosphorylation|signal transduction|regulation of gene expression|intracellular signal transduction|metal ion binding|regulation of cell cycle|ciliary base MON1A 175.5240401 212.1257974 138.9222827 0.654905176 -0.610642061 0.278316958 1 4.468978079 3.052829693 84315 "MON1 homolog A, secretory trafficking associated" "GO:0005085,GO:0005515,GO:0005829,GO:0006623,GO:0009306,GO:0016192,GO:0035658,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|cytosol|protein targeting to vacuole|protein secretion|vesicle-mediated transport|Mon1-Ccz1 complex|regulation of catalytic activity MON1B 1188.076969 1134.720773 1241.433165 1.094042865 0.129669264 0.706477817 1 9.88639327 11.28205338 22879 "MON1 homolog B, secretory trafficking associated" "GO:0005515,GO:0005737,GO:0006623,GO:0016192,GO:0019085,GO:0019086,GO:0035658" protein binding|cytoplasm|protein targeting to vacuole|vesicle-mediated transport|early viral transcription|late viral transcription|Mon1-Ccz1 complex MON2 1320.673221 1274.784696 1366.561746 1.071994157 0.100297042 0.767700377 1 5.39151129 6.028633283 23041 "MON2 homolog, regulator of endosome-to-Golgi trafficking" "GO:0005515,GO:0005829,GO:0006895,GO:0015031,GO:0070062" protein binding|cytosol|Golgi to endosome transport|protein transport|extracellular exosome MORC2 839.3178597 833.27885 845.3568694 1.014494571 0.020761144 0.958028588 1 6.974489196 7.380368776 22880 MORC family CW-type zinc finger 2 "GO:0000287,GO:0000792,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006338,GO:0006631,GO:0006974,GO:0008270,GO:0016363,GO:0016887,GO:0042803,GO:0045814,GO:0045869,GO:0090309" "magnesium ion binding|heterochromatin|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin remodeling|fatty acid metabolic process|cellular response to DNA damage stimulus|zinc ion binding|nuclear matrix|ATPase activity|protein homodimerization activity|negative regulation of gene expression, epigenetic|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|positive regulation of DNA methylation-dependent heterochromatin assembly" MORC3 711.2889093 702.3495301 720.2282885 1.025455642 0.036265087 0.927058564 1 7.43085982 7.948256564 23515 MORC family CW-type zinc finger 3 "GO:0003723,GO:0005515,GO:0005654,GO:0006468,GO:0007569,GO:0008270,GO:0009791,GO:0016032,GO:0016363,GO:0016605,GO:0018105,GO:0035064,GO:0048147,GO:0050821,GO:0051457" RNA binding|protein binding|nucleoplasm|protein phosphorylation|cell aging|zinc ion binding|post-embryonic development|viral process|nuclear matrix|PML body|peptidyl-serine phosphorylation|methylated histone binding|negative regulation of fibroblast proliferation|protein stabilization|maintenance of protein location in nucleus MORC4 659.2359204 680.0204988 638.4513419 0.93887073 -0.091001564 0.815249418 1 8.128543615 7.960392278 79710 MORC family CW-type zinc finger 4 "GO:0005515,GO:0005654,GO:0008270,GO:0035064" protein binding|nucleoplasm|zinc ion binding|methylated histone binding MORF4L1 5094.521734 5841.071598 4347.97187 0.744379143 -0.425890462 0.185536367 1 129.2396987 100.3473857 10933 mortality factor 4 like 1 "GO:0000123,GO:0000724,GO:0005515,GO:0005654,GO:0006342,GO:0016573,GO:0016575,GO:0016580,GO:0016607,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0047485" histone acetyltransferase complex|double-strand break repair via homologous recombination|protein binding|nucleoplasm|chromatin silencing|histone acetylation|histone deacetylation|Sin3 complex|nuclear speck|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|protein N-terminus binding MORF4L2 6783.729622 7287.383853 6280.075391 0.861773651 -0.214619106 0.511504962 1 186.9707618 168.0671512 9643 mortality factor 4 like 2 "GO:0000123,GO:0005515,GO:0005654,GO:0005730,GO:0005886,GO:0006281,GO:0006342,GO:0016573,GO:0016575,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0045944,GO:0051155" histone acetyltransferase complex|protein binding|nucleoplasm|nucleolus|plasma membrane|DNA repair|chromatin silencing|histone acetylation|histone deacetylation|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|positive regulation of transcription by RNA polymerase II|positive regulation of striated muscle cell differentiation MORN1 72.73809848 89.31612522 56.16007174 0.62877864 -0.669375886 0.376457623 1 2.313834606 1.517560528 79906 MORN repeat containing 1 MORN2 120.4910095 120.7797602 120.2022588 0.995218558 -0.006914707 1 1 8.414124856 8.734606564 729967 MORN repeat containing 2 "GO:0001669,GO:0005515,GO:0005634,GO:0007283,GO:0030154" acrosomal vesicle|protein binding|nucleus|spermatogenesis|cell differentiation MORN3 26.94359209 23.34398727 30.54319691 1.308396743 0.387800073 0.727721286 1 0.294835562 0.402378946 283385 MORN repeat containing 3 "GO:0005515,GO:0005634" protein binding|nucleus MORN4 473.1493605 385.683268 560.615453 1.453564361 0.539594953 0.193137717 1 7.579936715 11.49253343 118812 MORN repeat containing 4 "GO:0005515,GO:0005737,GO:0032426,GO:0032433,GO:0048678" protein binding|cytoplasm|stereocilium tip|filopodium tip|response to axon injury MOSMO 557.9360402 456.7301858 659.1418947 1.443175676 0.529246928 0.183548997 1 5.176051166 7.791726341 730094 modulator of smoothened "GO:0005794,GO:0005886,GO:0016021,GO:0030154,GO:0031647,GO:0045664,GO:0045879,GO:0060170" Golgi apparatus|plasma membrane|integral component of membrane|cell differentiation|regulation of protein stability|regulation of neuron differentiation|negative regulation of smoothened signaling pathway|ciliary membrane hsa04340 Hedgehog signaling pathway MOSPD1 286.5983761 295.3521868 277.8445655 0.940722899 -0.088158272 0.860788974 1 5.552541322 5.448405778 56180 motile sperm domain containing 1 "GO:0000122,GO:0000139,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0016021,GO:0030154,GO:0045944,GO:0048471" negative regulation of transcription by RNA polymerase II|Golgi membrane|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|integral component of membrane|cell differentiation|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm MOSPD2 669.6338989 582.5847258 756.6830719 1.298837814 0.377221293 0.322912116 1 6.782956581 9.189457868 158747 motile sperm domain containing 2 "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0006935,GO:0016020,GO:0035579,GO:0043312,GO:0044232,GO:0090023,GO:0090026,GO:0140284" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|chemotaxis|membrane|specific granule membrane|neutrophil degranulation|organelle membrane contact site|positive regulation of neutrophil chemotaxis|positive regulation of monocyte chemotaxis|endoplasmic reticulum-endosome membrane contact site MOSPD3 592.1988459 609.988537 574.4091548 0.941672048 -0.086703389 0.828626928 1 25.51095581 25.05776543 64598 motile sperm domain containing 3 "GO:0005515,GO:0005789,GO:0005886,GO:0007507,GO:0016021,GO:0033149,GO:0061817,GO:0090158" protein binding|endoplasmic reticulum membrane|plasma membrane|heart development|integral component of membrane|FFAT motif binding|endoplasmic reticulum-plasma membrane tethering|endoplasmic reticulum membrane organization MOV10 2153.774414 2188.245068 2119.30376 0.968494704 -0.046183935 0.88684233 1 20.8360393 21.04884877 4343 Mov10 RISC complex RNA helicase "GO:0000932,GO:0003723,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005829,GO:0007223,GO:0010494,GO:0010526,GO:0010628,GO:0010629,GO:0016032,GO:0032574,GO:0035194,GO:0035195,GO:0035279,GO:0036464,GO:0043186,GO:0045652,GO:0051607,GO:0061014,GO:0061158,GO:0150011" "P-body|RNA binding|protein binding|ATP binding|extracellular space|nucleus|cytosol|Wnt signaling pathway, calcium modulating pathway|cytoplasmic stress granule|negative regulation of transposition, RNA-mediated|positive regulation of gene expression|negative regulation of gene expression|viral process|5'-3' RNA helicase activity|post-transcriptional gene silencing by RNA|gene silencing by miRNA|mRNA cleavage involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|P granule|regulation of megakaryocyte differentiation|defense response to virus|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|regulation of neuron projection arborization" MOXD1 333.0691072 306.5167024 359.621512 1.17325258 0.230513633 0.617657278 1 5.116674243 6.261742667 26002 monooxygenase DBH like 1 "GO:0004500,GO:0005507,GO:0005515,GO:0005615,GO:0005789,GO:0006589,GO:0016021,GO:0030667,GO:0042420,GO:0042421,GO:0055114" dopamine beta-monooxygenase activity|copper ion binding|protein binding|extracellular space|endoplasmic reticulum membrane|octopamine biosynthetic process|integral component of membrane|secretory granule membrane|dopamine catabolic process|norepinephrine biosynthetic process|oxidation-reduction process MPC1 163.9708126 196.9014579 131.0401674 0.665511413 -0.587464688 0.308001148 1 2.551129244 1.770940208 51660 mitochondrial pyruvate carrier 1 "GO:0003674,GO:0005515,GO:0005739,GO:0006850,GO:0008150,GO:0031305,GO:0050833" molecular_function|protein binding|mitochondrion|mitochondrial pyruvate transmembrane transport|biological_process|integral component of mitochondrial inner membrane|pyruvate transmembrane transporter activity MPC2 461.7661176 483.1190409 440.4131942 0.911603884 -0.133521023 0.752466734 1 9.850352288 9.366424991 25874 mitochondrial pyruvate carrier 2 "GO:0005515,GO:0005634,GO:0005739,GO:0006850,GO:0031305,GO:0035774,GO:0042802,GO:0050833,GO:0061732" protein binding|nucleus|mitochondrion|mitochondrial pyruvate transmembrane transport|integral component of mitochondrial inner membrane|positive regulation of insulin secretion involved in cellular response to glucose stimulus|identical protein binding|pyruvate transmembrane transporter activity|mitochondrial acetyl-CoA biosynthetic process from pyruvate MPDU1 1107.768516 1066.718723 1148.81831 1.076964607 0.106970838 0.759257795 1 32.74275161 36.78176235 9526 mannose-P-dolichol utilization defect 1 "GO:0005515,GO:0005789,GO:0006457,GO:0006488,GO:0009312,GO:0016020,GO:0016021" protein binding|endoplasmic reticulum membrane|protein folding|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide biosynthetic process|membrane|integral component of membrane MPDZ 1093.187988 1012.926056 1173.44992 1.158475402 0.212227411 0.541768317 1 5.646173384 6.822710706 8777 multiple PDZ domain crumbs cell polarity complex component "GO:0005515,GO:0005737,GO:0005923,GO:0008022,GO:0014069,GO:0016032,GO:0016324,GO:0016327,GO:0030425" protein binding|cytoplasm|bicellular tight junction|protein C-terminus binding|postsynaptic density|viral process|apical plasma membrane|apicolateral plasma membrane|dendrite hsa04530 Tight junction MPG 847.8289408 808.9199068 886.7379749 1.096199967 0.132510996 0.717238467 1 24.19901924 27.66963812 4350 N-methylpurine DNA glycosylase "GO:0003684,GO:0003905,GO:0005515,GO:0005654,GO:0005829,GO:0006284,GO:0006307,GO:0008725,GO:0019104,GO:0042645,GO:0043916,GO:0045007,GO:0052821,GO:0052822" damaged DNA binding|alkylbase DNA N-glycosylase activity|protein binding|nucleoplasm|cytosol|base-excision repair|DNA dealkylation involved in DNA repair|DNA-3-methyladenine glycosylase activity|DNA N-glycosylase activity|mitochondrial nucleoid|DNA-7-methylguanine glycosylase activity|depurination|DNA-7-methyladenine glycosylase activity|DNA-3-methylguanine glycosylase activity hsa03410 Base excision repair MPHOSPH10 318.0917027 360.3093688 275.8740366 0.765658794 -0.385226479 0.407800906 1 8.432716466 6.734706949 10199 M-phase phosphoprotein 10 "GO:0000375,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005732,GO:0006364,GO:0006396,GO:0008380,GO:0010923,GO:0032040,GO:0034457" "RNA splicing, via transesterification reactions|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|sno(s)RNA-containing ribonucleoprotein complex|rRNA processing|RNA processing|RNA splicing|negative regulation of phosphatase activity|small-subunit processome|Mpp10 complex" hsa03008 Ribosome biogenesis in eukaryotes MPHOSPH6 125.3876401 118.7498483 132.0254318 1.11179453 0.15289019 0.818393186 1 4.345564228 5.039490561 10200 M-phase phosphoprotein 6 "GO:0000176,GO:0000178,GO:0000460,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006364" nuclear exosome (RNase complex)|exosome (RNase complex)|maturation of 5.8S rRNA|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|rRNA processing hsa03018 RNA degradation MPHOSPH8 657.6271334 637.3923481 677.8619186 1.063492401 0.088809725 0.819843786 1 7.378668308 8.185181401 54737 M-phase phosphoprotein 8 "GO:0000786,GO:0000792,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0035064,GO:0044030,GO:0045814,GO:0045869,GO:0045892,GO:0090309" "nucleosome|heterochromatin|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|methylated histone binding|regulation of DNA methylation|negative regulation of gene expression, epigenetic|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of transcription, DNA-templated|positive regulation of DNA methylation-dependent heterochromatin assembly" MPHOSPH9 1254.801044 1014.955968 1494.64612 1.472621637 0.558386804 0.100664349 1 6.078989977 9.337670275 10198 M-phase phosphoprotein 9 "GO:0000139,GO:0005794,GO:0005814,GO:0016020" Golgi membrane|Golgi apparatus|centriole|membrane MPI 1427.845347 1798.501976 1057.188719 0.587816268 -0.766562809 0.022058711 0.647151013 48.19459278 29.54988844 4351 mannose phosphate isomerase "GO:0000032,GO:0004476,GO:0005829,GO:0006486,GO:0008270,GO:0009298,GO:0061611,GO:0070062" cell wall mannoprotein biosynthetic process|mannose-6-phosphate isomerase activity|cytosol|protein glycosylation|zinc ion binding|GDP-mannose biosynthetic process|mannose to fructose-6-phosphate metabolic process|extracellular exosome "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism MPL 7.971189988 6.08973581 9.852644165 1.617909951 0.694131313 0.702268135 1 0.064972327 0.10964749 4352 "MPL proto-oncogene, thrombopoietin receptor" "GO:0001780,GO:0005515,GO:0005794,GO:0005886,GO:0009986,GO:0016021,GO:0031965,GO:0035702,GO:0038163,GO:0038164,GO:0043005,GO:0043025,GO:0050671,GO:0070527,GO:0071456,GO:1905221,GO:1990959,GO:1990960" neutrophil homeostasis|protein binding|Golgi apparatus|plasma membrane|cell surface|integral component of membrane|nuclear membrane|monocyte homeostasis|thrombopoietin-mediated signaling pathway|thrombopoietin receptor activity|neuron projection|neuronal cell body|positive regulation of lymphocyte proliferation|platelet aggregation|cellular response to hypoxia|positive regulation of platelet formation|eosinophil homeostasis|basophil homeostasis "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway MPLKIP 490.6532685 470.9395693 510.3669678 1.083720717 0.115993011 0.781297072 1 3.127235848 3.535036817 136647 M-phase specific PLK1 interacting protein "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0007049,GO:0030496,GO:0043231,GO:0051301" protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cell cycle|midbody|intracellular membrane-bounded organelle|cell division MPND 221.4400343 252.7240361 190.1560324 0.752425592 -0.410379176 0.432970123 1 7.900975847 6.200978454 84954 MPN domain containing "GO:0003713,GO:0004843,GO:0005515,GO:0006338,GO:0006508,GO:0008237,GO:0018215,GO:0042393,GO:0045944,GO:0046872,GO:0070122" transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|protein binding|chromatin remodeling|proteolysis|metallopeptidase activity|protein phosphopantetheinylation|histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding|isopeptidase activity MPP1 636.1470329 617.0932288 655.200837 1.061753405 0.086448736 0.826075294 1 14.55686775 16.12157725 4354 membrane palmitoylated protein 1 "GO:0004385,GO:0005515,GO:0005886,GO:0007165,GO:0016020,GO:0030863,GO:0032420,GO:0034451,GO:0046037,GO:0046710,GO:0090022" guanylate kinase activity|protein binding|plasma membrane|signal transduction|membrane|cortical cytoskeleton|stereocilium|centriolar satellite|GMP metabolic process|GDP metabolic process|regulation of neutrophil chemotaxis MPP2 810.295859 667.8410272 952.7506908 1.426612999 0.512594024 0.162097272 1 5.625110931 8.370534642 4355 membrane palmitoylated protein 2 "GO:0005515,GO:0005737,GO:0005856,GO:0014069,GO:0032590,GO:0043197,GO:0043198,GO:0051260,GO:0060079,GO:0060291" protein binding|cytoplasm|cytoskeleton|postsynaptic density|dendrite membrane|dendritic spine|dendritic shaft|protein homooligomerization|excitatory postsynaptic potential|long-term synaptic potentiation MPP3 156.6434342 167.4677348 145.8191336 0.870729719 -0.19970313 0.739837105 1 2.482918611 2.255079107 4356 membrane palmitoylated protein 3 GO:0005515 protein binding MPP4 5.015396738 6.08973581 3.941057666 0.64716398 -0.627796782 0.826813936 1 0.076588934 0.051700684 58538 membrane palmitoylated protein 4 "GO:0005515,GO:0005829,GO:0005912,GO:0008150,GO:0015629,GO:0032991,GO:0035418" protein binding|cytosol|adherens junction|biological_process|actin cytoskeleton|protein-containing complex|protein localization to synapse hsa04530 Tight junction MPP7 138.6859881 152.2433953 125.1285809 0.821898255 -0.282968285 0.647798468 1 1.193220503 1.022950679 143098 membrane palmitoylated protein 7 "GO:0005515,GO:0005654,GO:0005912,GO:0005923,GO:0005938,GO:0016328,GO:0019904,GO:0030010,GO:0030054,GO:0031334,GO:0035591,GO:0045296,GO:0060090,GO:0070830,GO:0071896,GO:0097025" protein binding|nucleoplasm|adherens junction|bicellular tight junction|cell cortex|lateral plasma membrane|protein domain specific binding|establishment of cell polarity|cell junction|positive regulation of protein-containing complex assembly|signaling adaptor activity|cadherin binding|molecular adaptor activity|bicellular tight junction assembly|protein localization to adherens junction|MPP7-DLG1-LIN7 complex MPPE1 231.6192855 275.0530674 188.1855036 0.684178894 -0.547554495 0.287190255 1 2.831395841 2.020627189 65258 metallophosphoesterase 1 "GO:0005515,GO:0005654,GO:0005793,GO:0005794,GO:0005801,GO:0006506,GO:0006888,GO:0016021,GO:0030145,GO:0033116,GO:0034235,GO:0062050,GO:0070971" protein binding|nucleoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|GPI anchor biosynthetic process|endoplasmic reticulum to Golgi vesicle-mediated transport|integral component of membrane|manganese ion binding|endoplasmic reticulum-Golgi intermediate compartment membrane|GPI anchor binding|GPI-mannose ethanolamine phosphate phosphodiesterase activity|endoplasmic reticulum exit site MPRIP 5855.020417 5731.456353 5978.58448 1.043117859 0.060902173 0.851241102 1 19.18559451 20.87490809 23164 myosin phosphatase Rho interacting protein "GO:0005515,GO:0005829,GO:0005925,GO:0007015,GO:0015629,GO:0045296,GO:0051015" protein binding|cytosol|focal adhesion|actin filament organization|actin cytoskeleton|cadherin binding|actin filament binding MPST 1096.894235 963.193214 1230.595256 1.277620355 0.353459203 0.308505071 1 35.42653475 47.21135074 4357 mercaptopyruvate sulfurtransferase "GO:0000098,GO:0001822,GO:0001889,GO:0004792,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0009440,GO:0009636,GO:0016784,GO:0019346,GO:0021510,GO:0042802,GO:0043005,GO:0045202,GO:0070062,GO:0070814" sulfur amino acid catabolic process|kidney development|liver development|thiosulfate sulfurtransferase activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|cyanate catabolic process|response to toxic substance|3-mercaptopyruvate sulfurtransferase activity|transsulfuration|spinal cord development|identical protein binding|neuron projection|synapse|extracellular exosome|hydrogen sulfide biosynthetic process "hsa00270,hsa00920,hsa04122" Cysteine and methionine metabolism|Sulfur metabolism|Sulfur relay system MPV17 462.0009284 532.8518834 391.1499734 0.734068858 -0.446012697 0.285040366 1 22.75469486 17.42303246 4358 mitochondrial inner membrane protein MPV17 "GO:0000002,GO:0005737,GO:0005739,GO:0005743,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0015267,GO:0016021,GO:0032836,GO:0034614,GO:0042592,GO:0048839,GO:0055085,GO:1901858,GO:2000377" mitochondrial genome maintenance|cytoplasm|mitochondrion|mitochondrial inner membrane|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|channel activity|integral component of membrane|glomerular basement membrane development|cellular response to reactive oxygen species|homeostatic process|inner ear development|transmembrane transport|regulation of mitochondrial DNA metabolic process|regulation of reactive oxygen species metabolic process hsa04146 Peroxisome MPV17L2 362.3840641 357.2645009 367.5036274 1.028659793 0.04076592 0.933631862 1 11.46653144 12.3032475 84769 MPV17 mitochondrial inner membrane protein like 2 "GO:0005737,GO:0005739,GO:0005743,GO:0005762,GO:0016021,GO:0061668,GO:0070131" cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|integral component of membrane|mitochondrial ribosome assembly|positive regulation of mitochondrial translation hsa04146 Peroxisome MPZ 19.50957164 20.29911937 18.72002391 0.922208672 -0.116834863 0.96691613 1 0.380910999 0.366411119 4359 myelin protein zero "GO:0005198,GO:0005886,GO:0005887,GO:0007268,GO:0042552,GO:0043209,GO:0045202,GO:0098742,GO:0098743" structural molecule activity|plasma membrane|integral component of plasma membrane|chemical synaptic transmission|myelination|myelin sheath|synapse|cell-cell adhesion via plasma-membrane adhesion molecules|cell aggregation hsa04514 Cell adhesion molecules MPZL1 2811.107353 2771.84475 2850.369957 1.028329584 0.040302728 0.900304392 1 28.20091565 30.24903116 9019 myelin protein zero like 1 "GO:0005198,GO:0005515,GO:0005887,GO:0005925,GO:0007169,GO:0007267,GO:0009986" structural molecule activity|protein binding|integral component of plasma membrane|focal adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|cell-cell signaling|cell surface hsa04514 Cell adhesion molecules MPZL2 17.09094793 23.34398727 10.83790858 0.464269812 -1.106964619 0.35175282 1 0.400912378 0.194149305 10205 myelin protein zero like 2 "GO:0005515,GO:0005856,GO:0007156,GO:0009653,GO:0016021" protein binding|cytoskeleton|homophilic cell adhesion via plasma membrane adhesion molecules|anatomical structure morphogenesis|integral component of membrane MPZL3 84.53157993 87.28621328 81.77694657 0.936882739 -0.094059605 0.912000963 1 0.932645311 0.911418162 196264 myelin protein zero like 3 "GO:0005515,GO:0007155,GO:0016021,GO:0030198,GO:0042633" protein binding|cell adhesion|integral component of membrane|extracellular matrix organization|hair cycle MR1 169.1104188 144.1237475 194.0970901 1.346739128 0.429470419 0.453125544 1 0.868557755 1.220107538 3140 "major histocompatibility complex, class I-related" "GO:0000139,GO:0002474,GO:0002854,GO:0005515,GO:0005615,GO:0005783,GO:0005789,GO:0005886,GO:0006955,GO:0009897,GO:0016021,GO:0019884,GO:0030881,GO:0031901,GO:0031902,GO:0032393,GO:0033077,GO:0042608,GO:0042612,GO:0045087,GO:0050829,GO:0050830" Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity directed against tumor cell target|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|immune response|external side of plasma membrane|integral component of membrane|antigen processing and presentation of exogenous antigen|beta-2-microglobulin binding|early endosome membrane|late endosome membrane|MHC class I receptor activity|T cell differentiation in thymus|T cell receptor binding|MHC class I protein complex|innate immune response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium MRAP2 10.49373413 10.14955968 10.83790858 1.067820568 0.094669242 1 1 0.119627506 0.133243263 112609 melanocortin 2 receptor accessory protein 2 "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006112,GO:0007631,GO:0016021,GO:0030545,GO:0031780,GO:0031781,GO:0031782,GO:0031783,GO:0042802,GO:0070996,GO:0072659,GO:0097009,GO:0106070,GO:0106071,GO:0106072,GO:1903077" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|energy reserve metabolic process|feeding behavior|integral component of membrane|receptor regulator activity|corticotropin hormone receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding|identical protein binding|type 1 melanocortin receptor binding|protein localization to plasma membrane|energy homeostasis|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|negative regulation of protein localization to plasma membrane MRAS 294.4602025 361.3243247 227.5960802 0.629894155 -0.666818671 0.161301339 1 3.228617215 2.121290105 22808 muscle RAS oncogene homolog "GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0007265,GO:0007275,GO:0007517,GO:0019003,GO:0030036,GO:0030742,GO:1990830" GTPase activity|protein binding|GTP binding|plasma membrane|Ras protein signal transduction|multicellular organism development|muscle organ development|GDP binding|actin cytoskeleton organization|GTP-dependent protein binding|cellular response to leukemia inhibitory factor "hsa04010,hsa04014,hsa04015,hsa04072,hsa04137,hsa04140,hsa04218,hsa04371,hsa04625,hsa04810,hsa05205" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Cellular senescence|Apelin signaling pathway|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Proteoglycans in cancer MRC2 7784.316117 8503.301103 7065.331131 0.830892737 -0.267265848 0.418024821 1 73.44171266 63.65077395 9902 mannose receptor C type 2 "GO:0001649,GO:0005515,GO:0005518,GO:0005925,GO:0006897,GO:0016020,GO:0016021,GO:0030246,GO:0030574,GO:0038023" osteoblast differentiation|protein binding|collagen binding|focal adhesion|endocytosis|membrane|integral component of membrane|carbohydrate binding|collagen catabolic process|signaling receptor activity "hsa04145,hsa05152" Phagosome|Tuberculosis MRE11 1165.644017 1082.958018 1248.330016 1.152703978 0.205022067 0.551493156 1 7.294587469 8.770704072 4361 "MRE11 homolog, double strand break repair nuclease" "GO:0000014,GO:0000019,GO:0000723,GO:0000724,GO:0000729,GO:0000781,GO:0003677,GO:0003678,GO:0003690,GO:0004518,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005829,GO:0006260,GO:0006281,GO:0006302,GO:0006303,GO:0006310,GO:0006974,GO:0007004,GO:0007062,GO:0007095,GO:0007129,GO:0007131,GO:0008022,GO:0008283,GO:0008408,GO:0008409,GO:0016032,GO:0016605,GO:0030145,GO:0030870,GO:0031573,GO:0031860,GO:0031954,GO:0032206,GO:0032481,GO:0032508,GO:0033674,GO:0035861,GO:0042138,GO:0042802,GO:0043066,GO:0045296,GO:0097552,GO:0110025,GO:1901796" "single-stranded DNA endodeoxyribonuclease activity|regulation of mitotic recombination|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|chromosome, telomeric region|DNA binding|DNA helicase activity|double-stranded DNA binding|nuclease activity|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|replication fork|cytoplasm|cytosol|DNA replication|DNA repair|double-strand break repair|double-strand break repair via nonhomologous end joining|DNA recombination|cellular response to DNA damage stimulus|telomere maintenance via telomerase|sister chromatid cohesion|mitotic G2 DNA damage checkpoint|homologous chromosome pairing at meiosis|reciprocal meiotic recombination|protein C-terminus binding|cell population proliferation|3'-5' exonuclease activity|5'-3' exonuclease activity|viral process|PML body|manganese ion binding|Mre11 complex|intra-S DNA damage checkpoint|telomeric 3' overhang formation|positive regulation of protein autophosphorylation|positive regulation of telomere maintenance|positive regulation of type I interferon production|DNA duplex unwinding|positive regulation of kinase activity|site of double-strand break|meiotic DNA double-strand break formation|identical protein binding|negative regulation of apoptotic process|cadherin binding|mitochondrial double-strand break repair via homologous recombination|DNA strand resection involved in replication fork processing|regulation of signal transduction by p53 class mediator" "hsa03440,hsa03450,hsa04218" Homologous recombination|Non-homologous end-joining|Cellular senescence MREG 106.8903028 133.9741878 79.80641774 0.595685027 -0.747378398 0.260579641 1 1.884287693 1.170792213 55686 melanoregulin "GO:0005515,GO:0005765,GO:0016324,GO:0030318,GO:0030659,GO:0031300,GO:0031902,GO:0032400,GO:0032402,GO:0032991,GO:0033162,GO:0035091,GO:0042470,GO:0072385,GO:0090382" protein binding|lysosomal membrane|apical plasma membrane|melanocyte differentiation|cytoplasmic vesicle membrane|intrinsic component of organelle membrane|late endosome membrane|melanosome localization|melanosome transport|protein-containing complex|melanosome membrane|phosphatidylinositol binding|melanosome|minus-end-directed organelle transport along microtubule|phagosome maturation MRFAP1 3790.270409 4005.016251 3575.524568 0.892761563 -0.16365318 0.607521019 1 139.4088964 129.8200891 93621 Morf4 family associated protein 1 "GO:0005515,GO:0005654,GO:0048471" protein binding|nucleoplasm|perinuclear region of cytoplasm MRFAP1L1 786.1959749 737.872989 834.5189608 1.130979143 0.177572324 0.631649769 1 23.60749453 27.84969372 114932 Morf4 family associated protein 1 like 1 "GO:0005515,GO:0042802" protein binding|identical protein binding MRGBP 1417.556979 1465.596418 1369.517539 0.934443836 -0.097820141 0.771047878 1 26.9721251 26.28961939 55257 MRG domain binding protein "GO:0005515,GO:0005654,GO:0006357,GO:0016573,GO:0035267,GO:0040008" protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|histone acetylation|NuA4 histone acetyltransferase complex|regulation of growth MRGPRX4 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.142393184 0.036045473 117196 MAS related GPR family member X4 "GO:0004930,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane MRI1 647.7744892 637.3923481 658.1566303 1.032576924 0.046249262 0.908146274 1 9.425306233 10.15158405 84245 methylthioribose-1-phosphate isomerase 1 "GO:0001650,GO:0005515,GO:0005654,GO:0005829,GO:0019284,GO:0019509,GO:0042802,GO:0042995,GO:0046523" fibrillar center|protein binding|nucleoplasm|cytosol|L-methionine salvage from S-adenosylmethionine|L-methionine salvage from methylthioadenosine|identical protein binding|cell projection|S-methyl-5-thioribose-1-phosphate isomerase activity hsa00270 Cysteine and methionine metabolism MRM1 205.5152217 208.0659735 202.9644698 0.975481317 -0.035813854 0.95635622 1 2.344339832 2.385368348 79922 mitochondrial rRNA methyltransferase 1 "GO:0000451,GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0070039" rRNA 2'-O-methylation|RNA binding|protein binding|mitochondrion|mitochondrial matrix|rRNA (guanosine-2'-O-)-methyltransferase activity MRM2 557.6227951 637.3923481 477.853242 0.749700312 -0.415614093 0.296360878 1 18.94464428 14.81460499 29960 mitochondrial rRNA methyltransferase 2 "GO:0000451,GO:0001510,GO:0005730,GO:0005739,GO:0005759,GO:0006364,GO:0008173,GO:0008650,GO:0031167" rRNA 2'-O-methylation|RNA methylation|nucleolus|mitochondrion|mitochondrial matrix|rRNA processing|RNA methyltransferase activity|rRNA (uridine-2'-O-)-methyltransferase activity|rRNA methylation MRM3 334.5442823 340.0102494 329.0783151 0.967848221 -0.047147274 0.924527035 1 9.959699045 10.05470658 55178 mitochondrial rRNA methyltransferase 3 "GO:0000451,GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0042802,GO:0070039" rRNA 2'-O-methylation|RNA binding|protein binding|mitochondrion|mitochondrial matrix|identical protein binding|rRNA (guanosine-2'-O-)-methyltransferase activity MRNIP 137.5671117 143.1087915 132.0254318 0.922552908 -0.116296443 0.859467633 1 6.205441296 5.971451144 51149 MRN complex interacting protein "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006974,GO:0007095,GO:0010212,GO:0030870,GO:0045860,GO:0071168,GO:1905168,GO:2001032" chromatin binding|protein binding|nucleus|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|response to ionizing radiation|Mre11 complex|positive regulation of protein kinase activity|protein localization to chromatin|positive regulation of double-strand break repair via homologous recombination|regulation of double-strand break repair via nonhomologous end joining MROH1 1890.965644 1599.570606 2182.360683 1.364341577 0.448204883 0.166355291 1 11.8128621 16.81102437 727957 maestro heat like repeat family member 1 MROH6 46.16837239 57.8524902 34.48425458 0.596072087 -0.746441278 0.39458131 1 0.823271856 0.511868005 642475 maestro heat like repeat family member 6 MROH8 29.92907689 25.37389921 34.48425458 1.359044359 0.442592546 0.673478543 1 0.349116675 0.494903078 140699 maestro heat like repeat family member 8 MRPL1 236.8749363 263.8885518 209.8613207 0.795264968 -0.330492474 0.519658737 1 11.37448868 9.435385846 65008 mitochondrial ribosomal protein L1 "GO:0000470,GO:0003723,GO:0003735,GO:0005515,GO:0005743,GO:0022625,GO:0070125,GO:0070126" maturation of LSU-rRNA|RNA binding|structural constituent of ribosome|protein binding|mitochondrial inner membrane|cytosolic large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL10 1279.010046 1255.500533 1302.519559 1.037450423 0.053042395 0.877697 1 31.49414208 34.08105766 124995 mitochondrial ribosomal protein L10 "GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0015934,GO:0042254,GO:0070125,GO:0070126,GO:1990904" RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|large ribosomal subunit|ribosome biogenesis|mitochondrial translational elongation|mitochondrial translational termination|ribonucleoprotein complex hsa03010 Ribosome MRPL11 1353.867131 1354.966218 1352.768044 0.998377691 -0.002342398 0.996955987 1 28.56963318 29.75195182 65003 mitochondrial ribosomal protein L11 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0015934,GO:0070125,GO:0070126,GO:0070180" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination|large ribosomal subunit rRNA binding hsa03010 Ribosome MRPL12 1038.346469 1136.750685 939.9422534 0.82686755 -0.274271842 0.433836374 1 57.05888202 49.21246697 6182 mitochondrial ribosomal protein L12 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0006390,GO:0045893,GO:0070125,GO:0070126" "RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial transcription|positive regulation of transcription, DNA-templated|mitochondrial translational elongation|mitochondrial translational termination" hsa03010 Ribosome MRPL13 1491.006437 1435.147739 1546.865134 1.077843829 0.108148158 0.745752185 1 57.68664293 64.85553335 28998 mitochondrial ribosomal protein L13 "GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0017148,GO:0070125,GO:0070126" RNA binding|mRNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|ribosome|translation|negative regulation of translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL14 685.0160987 691.1850145 678.847183 0.982149741 -0.025985097 0.949487822 1 25.58924169 26.21507185 64928 mitochondrial ribosomal protein L14 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL15 2342.618575 2165.916037 2519.321113 1.163166564 0.218057703 0.495330827 1 51.91481607 62.98674401 29088 mitochondrial ribosomal protein L15 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126,GO:1990830" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination|cellular response to leukemia inhibitory factor hsa03010 Ribosome MRPL16 1049.180418 1001.761541 1096.599296 1.094670988 0.130497322 0.710498647 1 46.84735738 53.49148265 54948 mitochondrial ribosomal protein L16 "GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0019843,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|rRNA binding|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL17 1529.852628 1767.038341 1292.666915 0.73154435 -0.450982764 0.172906255 1 38.8261424 29.62653309 63875 mitochondrial ribosomal protein L17 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0015934,GO:0019904,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|large ribosomal subunit|protein domain specific binding|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL18 651.1256752 731.7832532 570.4680972 0.779558831 -0.359270193 0.349505307 1 45.1428017 36.7073755 29074 mitochondrial ribosomal protein L18 "GO:0003735,GO:0005515,GO:0005615,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0008097,GO:0035928,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|extracellular space|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|5S rRNA binding|rRNA import into mitochondrion|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL19 766.9603082 837.3386739 696.5819425 0.83189988 -0.265518186 0.474372834 1 5.419584649 4.702761948 9801 mitochondrial ribosomal protein L19 "GO:0003735,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005762,GO:0031965,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|nuclear membrane|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL2 450.2128901 467.8947014 432.5310789 0.924419699 -0.113380092 0.791187953 1 14.68228996 14.15725054 51069 mitochondrial ribosomal protein L2 "GO:0003723,GO:0003735,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL20 1026.6866 1147.9152 905.4579988 0.788784745 -0.342296444 0.329352606 1 55.63431128 45.77381909 55052 mitochondrial ribosomal protein L20 "GO:0000027,GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0019843,GO:0070125,GO:0070126" ribosomal large subunit assembly|RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|rRNA binding|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL21 605.5983928 684.0803227 527.1164629 0.770547618 -0.376043981 0.33541846 1 34.26929283 27.54359059 219927 mitochondrial ribosomal protein L21 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL22 663.9071427 696.2597943 631.554491 0.907067299 -0.140718501 0.715103887 1 11.11348954 10.51491788 29093 mitochondrial ribosomal protein L22 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0015934,GO:0042255,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|large ribosomal subunit|ribosome assembly|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL23 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.092786894 0.031317487 6150 mitochondrial ribosomal protein L23 "GO:0001650,GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0032543,GO:0070125,GO:0070126" fibrillar center|RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL24 1242.796754 1406.728972 1078.864536 0.76693134 -0.382830669 0.260613157 1 65.72496291 52.57784295 79590 mitochondrial ribosomal protein L24 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL27 775.93433 810.9498187 740.9188412 0.913643266 -0.130297123 0.726683211 1 59.87135198 57.0573573 51264 mitochondrial ribosomal protein L27 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL28 1393.860652 1529.538644 1258.18266 0.822589651 -0.281755173 0.400127684 1 49.05999775 42.09462986 10573 mitochondrial ribosomal protein L28 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0005829,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|cytosol|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL3 1170.900906 1240.276193 1101.525618 0.888129292 -0.171158378 0.619177645 1 36.77729143 34.06997894 11222 mitochondrial ribosomal protein L3 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL30 987.7740983 1080.928106 894.6200902 0.827640696 -0.272923509 0.440070972 1 12.34389973 10.65639113 51263 mitochondrial ribosomal protein L30 "GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL32 530.0556804 571.4202102 488.6911506 0.855222027 -0.225629083 0.577104746 1 33.69082398 30.05428778 64983 mitochondrial ribosomal protein L32 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL33 458.0234982 429.3263746 486.7206218 1.133684419 0.181019097 0.667777459 1 42.80288642 50.61522416 9553 mitochondrial ribosomal protein L33 "GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL34 518.5497119 525.7471916 511.3522322 0.972619997 -0.040051841 0.926066328 1 29.45491209 29.88249498 64981 mitochondrial ribosomal protein L34 "GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL35 450.6933982 433.3861985 468.0005979 1.079869639 0.110857162 0.795815955 1 13.17495922 14.84009019 51318 mitochondrial ribosomal protein L35 "GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL36 823.961146 962.178258 685.7440339 0.712699573 -0.488634034 0.181094315 1 39.61864586 29.45249263 64979 mitochondrial ribosomal protein L36 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0016604,GO:0042254,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|nuclear body|ribosome biogenesis|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL37 2240.106538 2162.871169 2317.341908 1.071419297 0.099523186 0.756801287 1 59.27586285 66.24502654 51253 mitochondrial ribosomal protein L37 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL38 909.2216528 897.221076 921.2222295 1.026750546 0.038085714 0.91845241 1 33.461769 35.83684504 64978 mitochondrial ribosomal protein L38 "GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL39 431.421359 429.3263746 433.5163433 1.009759402 0.014011579 0.979777053 1 6.678091616 7.033738339 54148 mitochondrial ribosomal protein L39 "GO:0000166,GO:0003723,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0070125,GO:0070126" nucleotide binding|RNA binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL4 959.6401225 1009.881189 909.3990565 0.900501036 -0.151200159 0.671654379 1 26.8911249 25.25859075 51073 mitochondrial ribosomal protein L4 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL40 626.0459699 734.8281211 517.2638187 0.70392491 -0.506506556 0.190941497 1 50.02211292 36.72859334 64976 mitochondrial ribosomal protein L40 "GO:0003723,GO:0005515,GO:0005634,GO:0005730,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0009653,GO:0070125,GO:0070126" RNA binding|protein binding|nucleus|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|anatomical structure morphogenesis|mitochondrial translational elongation|mitochondrial translational termination MRPL41 613.7531753 635.3624362 592.1439143 0.93197816 -0.101631947 0.79710291 1 55.29014771 53.74887953 64975 mitochondrial ribosomal protein L41 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0006915,GO:0007049,GO:0070125,GO:0070126,GO:1990904" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|apoptotic process|cell cycle|mitochondrial translational elongation|mitochondrial translational termination|ribonucleoprotein complex MRPL42 991.4088378 992.6269371 990.1907386 0.997545706 -0.00354515 0.995250526 1 3.230915976 3.361819539 28977 mitochondrial ribosomal protein L42 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0005763,GO:0005886,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit|plasma membrane|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL43 2550.924802 2564.793732 2537.055873 0.98918515 -0.015687513 0.96208244 1 44.6384036 46.05769211 84545 mitochondrial ribosomal protein L43 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL44 453.2995738 510.5228521 396.0762955 0.775824811 -0.36619718 0.382848399 1 13.55145778 10.96643858 65080 mitochondrial ribosomal protein L44 "GO:0003723,GO:0003725,GO:0004525,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0005886,GO:0006396,GO:0016604,GO:0030422,GO:0031053,GO:0031054,GO:0070125,GO:0070126,GO:0090502" "RNA binding|double-stranded RNA binding|ribonuclease III activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|plasma membrane|RNA processing|nuclear body|production of siRNA involved in RNA interference|primary miRNA processing|pre-miRNA processing|mitochondrial translational elongation|mitochondrial translational termination|RNA phosphodiester bond hydrolysis, endonucleolytic" MRPL45 1344.099602 1226.06681 1462.132394 1.192538924 0.254036356 0.450502852 1 39.98451939 49.73709011 84311 mitochondrial ribosomal protein L45 "GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL46 386.9832614 388.7281359 385.2383869 0.991022649 -0.013010066 0.982914826 1 19.96725024 20.64038388 26589 mitochondrial ribosomal protein L46 "GO:0003674,GO:0003735,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0008150,GO:0016787,GO:0030054,GO:0070125,GO:0070126" molecular_function|structural constituent of ribosome|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|biological_process|hydrolase activity|cell junction|mitochondrial translational elongation|mitochondrial translational termination MRPL47 715.2893501 706.409354 724.1693462 1.025141219 0.035822663 0.927890357 1 26.2680923 28.08847491 57129 mitochondrial ribosomal protein L47 "GO:0003674,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0008150,GO:0032543,GO:0070125,GO:0070126" molecular_function|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|biological_process|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPL48 520.3596588 481.089129 559.6301886 1.163256775 0.218169589 0.591675029 1 21.0956426 25.59671774 51642 mitochondrial ribosomal protein L48 "GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0070125,GO:0070126" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL49 2071.363304 1909.132177 2233.594432 1.169952746 0.226450261 0.481494344 1 47.72498012 58.24115875 740 mitochondrial ribosomal protein L49 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL50 579.9154539 578.524902 581.3060058 1.004807233 0.006918754 0.990964791 1 8.783047174 9.205426135 54534 mitochondrial ribosomal protein L50 "GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL51 1692.696645 1684.826908 1700.566383 1.009341895 0.013414942 0.969247147 1 95.02287211 100.042004 51258 mitochondrial ribosomal protein L51 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPL52 814.5796073 859.6677052 769.4915093 0.895103427 -0.159873702 0.66402815 1 35.65858849 33.29302814 122704 mitochondrial ribosomal protein L52 "GO:0003735,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126" structural constituent of ribosome|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL53 559.4448662 627.2427885 491.6469439 0.783822394 -0.351401304 0.377173769 1 64.04765011 52.36448022 116540 mitochondrial ribosomal protein L53 "GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL54 275.1342234 286.2175831 264.0508636 0.922552908 -0.116296443 0.817066183 1 23.84195866 22.94294387 116541 mitochondrial ribosomal protein L54 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL55 451.9310408 450.64045 453.2216316 1.005727807 0.008239903 0.990315001 1 16.63509404 17.45105343 128308 mitochondrial ribosomal protein L55 "GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL57 531.7265721 584.6146378 478.8385064 0.819066913 -0.287946779 0.475347801 1 12.91826746 11.0367088 78988 mitochondrial ribosomal protein L57 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPL58 423.3880643 452.6703619 394.1057666 0.870624189 -0.199877991 0.642360068 1 20.91802637 18.99622763 3396 mitochondrial ribosomal protein L58 "GO:0004045,GO:0005739,GO:0005743,GO:0005759,GO:0005762,GO:0016150,GO:0070125,GO:0070126" "aminoacyl-tRNA hydrolase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial large ribosomal subunit|translation release factor activity, codon nonspecific|mitochondrial translational elongation|mitochondrial translational termination" MRPL9 1170.701229 1125.586169 1215.81629 1.080162784 0.111248748 0.747584252 1 46.57432077 52.47490606 65005 mitochondrial ribosomal protein L9 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS10 908.4739208 913.4603715 903.48747 0.989082283 -0.015837549 0.968118814 1 21.65896317 22.34529102 55173 mitochondrial ribosomal protein S10 "GO:0003674,GO:0005739,GO:0005743,GO:0005763,GO:0008150,GO:0070125,GO:0070126" molecular_function|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|biological_process|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS11 958.0798322 1105.28705 810.8726148 0.733630793 -0.4468739 0.208293024 1 14.80139869 11.32651328 64963 mitochondrial ribosomal protein S11 "GO:0000028,GO:0000462,GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0022627,GO:0032543,GO:0042769,GO:0048027,GO:0070125,GO:0070126,GO:0070181" "ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|cytosolic small ribosomal subunit|mitochondrial translation|DNA damage response, detection of DNA damage|mRNA 5'-UTR binding|mitochondrial translational elongation|mitochondrial translational termination|small ribosomal subunit rRNA binding" hsa03010 Ribosome MRPS12 539.2226973 558.2257826 520.2196119 0.931916132 -0.10172797 0.80341856 1 28.73187661 27.92908784 6183 mitochondrial ribosomal protein S12 "GO:0003723,GO:0003735,GO:0005515,GO:0005743,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial small ribosomal subunit|ribosome|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS14 520.9089525 518.6424998 523.1754052 1.008739942 0.012554289 0.980546037 1 12.41958059 13.06778791 63931 mitochondrial ribosomal protein S14 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005763,GO:0006412,GO:0015935,GO:0031965,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial small ribosomal subunit|translation|small ribosomal subunit|nuclear membrane|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS15 693.4920451 731.7832532 655.200837 0.895348225 -0.1594792 0.675550301 1 38.89007366 36.32006964 64960 mitochondrial ribosomal protein S15 "GO:0003723,GO:0003735,GO:0005654,GO:0005730,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|nucleoplasm|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS16 3202.041075 3228.574935 3175.507215 0.983563113 -0.023910465 0.941072859 1 63.40284248 65.04694305 51021 mitochondrial ribosomal protein S16 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005763,GO:0005829,GO:0006412,GO:0015935,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|cytosol|translation|small ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS17 533.035722 640.437216 425.6342279 0.66459946 -0.589442974 0.142995505 1 18.16119018 12.58984027 51373 mitochondrial ribosomal protein S17 "GO:0003735,GO:0005515,GO:0005743,GO:0005763,GO:0006412,GO:0019843,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|rRNA binding|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS18A 522.0547989 563.3005624 480.8090353 0.853556817 -0.228440905 0.573792857 1 20.56898795 18.31307562 55168 mitochondrial ribosomal protein S18A "GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126,GO:0070181" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination|small ribosomal subunit rRNA binding hsa03010 Ribosome MRPS18B 1006.739819 996.6867609 1016.792878 1.020172955 0.02881376 0.937679834 1 26.31838808 28.00586702 28973 mitochondrial ribosomal protein S18B "GO:0003735,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0030054,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|cell junction|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa05203 Viral carcinogenesis MRPS18C 307.3010531 329.8606897 284.7414164 0.863217186 -0.212204507 0.654828202 1 10.77824533 9.704743749 51023 mitochondrial ribosomal protein S18C "GO:0003735,GO:0005743,GO:0005763,GO:0006412,GO:0070125,GO:0070126,GO:0070181" structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination|small ribosomal subunit rRNA binding hsa03010 Ribosome MRPS2 1490.900786 2000.478214 981.3233589 0.490544387 -1.02754441 0.00212877 0.147899168 61.1449392 31.2863398 51116 mitochondrial ribosomal protein S2 "GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0032543,GO:0061668,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|mitochondrial translation|mitochondrial ribosome assembly|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS21 512.6029906 590.7043736 434.5016077 0.735565246 -0.443074779 0.275443318 1 19.42668353 14.90513097 54460 mitochondrial ribosomal protein S21 "GO:0003723,GO:0003735,GO:0005743,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS22 533.1356831 512.552764 553.7186021 1.080315318 0.111452461 0.785221926 1 18.41063072 20.74603617 56945 mitochondrial ribosomal protein S22 "GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005763,GO:0008150,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial small ribosomal subunit|biological_process|mitochondrial translational elongation|mitochondrial translational termination MRPS23 840.1019642 920.5650633 759.6388652 0.825187589 -0.277205972 0.446710328 1 8.312243341 7.154624838 51649 mitochondrial ribosomal protein S23 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005840,GO:0031965,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|ribosome|nuclear membrane|mitochondrial translational elongation|mitochondrial translational termination MRPS24 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.231202126 0 64951 mitochondrial ribosomal protein S24 "GO:0003723,GO:0003735,GO:0005743,GO:0005763,GO:0008150,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|biological_process|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPS25 1131.646951 1149.945112 1113.348791 0.968175593 -0.04665937 0.894917542 1 12.73855275 12.8644182 64432 mitochondrial ribosomal protein S25 "GO:0003735,GO:0005739,GO:0005743,GO:0005840,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|ribosome|mitochondrial translational elongation|mitochondrial translational termination MRPS26 1483.477898 1493.000229 1473.955567 0.987244033 -0.018521353 0.957680663 1 74.42440417 76.64005601 64949 mitochondrial ribosomal protein S26 "GO:0003723,GO:0005654,GO:0005739,GO:0005743,GO:0005763,GO:0042769,GO:0070125,GO:0070126" "RNA binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|DNA damage response, detection of DNA damage|mitochondrial translational elongation|mitochondrial translational termination" MRPS27 2228.713893 2192.304892 2265.122894 1.033215271 0.047140872 0.884240746 1 39.48524494 42.55411695 23107 mitochondrial ribosomal protein S27 "GO:0000049,GO:0005515,GO:0005730,GO:0005737,GO:0005739,GO:0005743,GO:0005763,GO:0008283,GO:0019843,GO:0070125,GO:0070126,GO:0070131,GO:0097177" tRNA binding|protein binding|nucleolus|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|cell population proliferation|rRNA binding|mitochondrial translational elongation|mitochondrial translational termination|positive regulation of mitochondrial translation|mitochondrial ribosome binding MRPS28 88.03938849 91.34603715 84.73273982 0.927601705 -0.108422623 0.893580549 1 5.520709466 5.341612266 28957 mitochondrial ribosomal protein S28 "GO:0003723,GO:0005739,GO:0005743,GO:0005763,GO:0008150,GO:0070125,GO:0070126" RNA binding|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|biological_process|mitochondrial translational elongation|mitochondrial translational termination MRPS30 703.7927841 728.7383853 678.847183 0.931537568 -0.102314142 0.789090668 1 22.39564829 21.76105479 10884 mitochondrial ribosomal protein S30 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006915,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|apoptotic process|mitochondrial translational elongation|mitochondrial translational termination MRPS31 239.5189682 242.5744764 236.46346 0.974807669 -0.036810494 0.951033888 1 8.267524549 8.406405982 10240 mitochondrial ribosomal protein S31 "GO:0003723,GO:0003735,GO:0005515,GO:0005730,GO:0005739,GO:0005743,GO:0005763,GO:0019904,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|protein domain specific binding|mitochondrial translational elongation|mitochondrial translational termination MRPS33 542.5347891 582.5847258 502.4848524 0.862509486 -0.213387771 0.596024148 1 6.800152369 6.117844778 51650 mitochondrial ribosomal protein S33 "GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPS34 1049.778209 1177.348923 922.2074939 0.783291576 -0.352378652 0.313467436 1 58.51675125 47.81009345 65993 mitochondrial ribosomal protein S34 "GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPS35 1068.268865 1060.628987 1075.908743 1.014406316 0.020635633 0.955651634 1 27.12985683 28.70617817 60488 mitochondrial ribosomal protein S35 "GO:0003723,GO:0003735,GO:0005743,GO:0005763,GO:0042769,GO:0070125,GO:0070126" "RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|DNA damage response, detection of DNA damage|mitochondrial translational elongation|mitochondrial translational termination" MRPS36 576.2916007 532.8518834 619.731318 1.163046125 0.217908313 0.582618036 1 20.52248525 24.89675929 92259 mitochondrial ribosomal protein S36 "GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006103,GO:0006412,GO:0009353,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|2-oxoglutarate metabolic process|translation|mitochondrial oxoglutarate dehydrogenase complex|mitochondrial translational elongation|mitochondrial translational termination MRPS5 848.482155 853.5779694 843.3863406 0.988060108 -0.017329285 0.965473157 1 11.42460701 11.77444824 64969 mitochondrial ribosomal protein S5 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS6 657.1048096 635.3624362 678.847183 1.068440853 0.095507045 0.806220272 1 34.56376581 38.52010558 64968 mitochondrial ribosomal protein S6 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0015935,GO:0032543,GO:0070125,GO:0070126,GO:0070181" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|small ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination|small ribosomal subunit rRNA binding hsa03010 Ribosome MRPS7 1277.559119 1291.023992 1264.094246 0.979140786 -0.030411781 0.930836672 1 54.30715176 55.46488251 51081 mitochondrial ribosomal protein S7 "GO:0000028,GO:0003723,GO:0003729,GO:0003735,GO:0005743,GO:0005763,GO:0005840,GO:0006412,GO:0019843,GO:0032543,GO:0070125,GO:0070126" ribosomal small subunit assembly|RNA binding|mRNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|ribosome|translation|rRNA binding|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS9 413.9538234 447.5955821 380.3120648 0.849677879 -0.23501209 0.586552057 1 13.8479763 12.27316444 64965 mitochondrial ribosomal protein S9 "GO:0003723,GO:0003735,GO:0005515,GO:0005730,GO:0005739,GO:0005743,GO:0005763,GO:0015935,GO:0042769,GO:0070125,GO:0070126" "RNA binding|structural constituent of ribosome|protein binding|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|small ribosomal subunit|DNA damage response, detection of DNA damage|mitochondrial translational elongation|mitochondrial translational termination" hsa03010 Ribosome MRRF 817.9065449 885.0416044 750.7714854 0.848289483 -0.237371419 0.51726003 1 18.87336212 16.69972368 92399 mitochondrial ribosome recycling factor "GO:0005515,GO:0005739,GO:0005759,GO:0006412,GO:0032790,GO:0043023,GO:0070126" protein binding|mitochondrion|mitochondrial matrix|translation|ribosome disassembly|ribosomal large subunit binding|mitochondrial translational termination MRS2 460.8281121 452.6703619 468.9858623 1.036042785 0.051083582 0.907704267 1 5.975021346 6.457034122 57380 magnesium transporter MRS2 "GO:0005739,GO:0005743,GO:0006089,GO:0015095,GO:0015693,GO:0016021,GO:0045016,GO:0055085" mitochondrion|mitochondrial inner membrane|lactate metabolic process|magnesium ion transmembrane transporter activity|magnesium ion transport|integral component of membrane|mitochondrial magnesium ion transmembrane transport|transmembrane transport MRTFA 1066.425267 968.2679938 1164.58254 1.202748152 0.266334583 0.445287077 1 9.959252243 12.49445624 57591 myocardin related transcription factor A "GO:0003713,GO:0003779,GO:0003785,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0010735,GO:0030036,GO:0043522,GO:0044319,GO:0045944,GO:0051145" "transcription coactivator activity|actin binding|actin monomer binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|positive regulation of transcription via serum response element binding|actin cytoskeleton organization|leucine zipper domain binding|wound healing, spreading of cells|positive regulation of transcription by RNA polymerase II|smooth muscle cell differentiation" MRTFB 1159.216788 1182.423703 1136.009872 0.96074687 -0.057771723 0.86884293 1 4.33137489 4.340609161 57496 myocardin related transcription factor B "GO:0003713,GO:0005515,GO:0005634,GO:0007517,GO:0045296,GO:0045844,GO:0045944,GO:0051145" transcription coactivator activity|protein binding|nucleus|muscle organ development|cadherin binding|positive regulation of striated muscle tissue development|positive regulation of transcription by RNA polymerase II|smooth muscle cell differentiation MRTO4 835.5292192 978.4175535 692.6408848 0.70791952 -0.498342738 0.171426558 1 20.30876944 14.99627606 51154 "MRT4 homolog, ribosome maturation factor" "GO:0000027,GO:0000956,GO:0003723,GO:0005515,GO:0005730,GO:0005737,GO:0006364,GO:0030687,GO:0042273" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process|RNA binding|protein binding|nucleolus|cytoplasm|rRNA processing|preribosome, large subunit precursor|ribosomal large subunit biogenesis" MSANTD1 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.027621676 0.027968653 345222 Myb/SANT DNA binding domain containing 1 "GO:0016604,GO:0045893" "nuclear body|positive regulation of transcription, DNA-templated" MSANTD2 816.837649 811.9647747 821.7105234 1.012002674 0.017213102 0.966124948 1 1.82623463 1.927765322 79684 Myb/SANT DNA binding domain containing 2 MSANTD3 641.6374945 655.6615556 627.6134333 0.957221646 -0.063075074 0.873595293 1 15.5172639 15.49328775 91283 Myb/SANT DNA binding domain containing 3 "GO:0005515,GO:0042802" protein binding|identical protein binding MSANTD4 670.5246454 643.4820839 697.5672069 1.084050705 0.116432239 0.762856192 1 7.675482215 8.679030124 84437 Myb/SANT DNA binding domain containing 4 with coiled-coils "GO:0005515,GO:0005634" protein binding|nucleus MSH2 1478.033458 1255.500533 1700.566383 1.354492761 0.437752683 0.187729926 1 6.268402292 8.85624207 4436 mutS homolog 2 "GO:0000287,GO:0000400,GO:0000406,GO:0000781,GO:0001701,GO:0002204,GO:0003677,GO:0003682,GO:0003690,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006119,GO:0006281,GO:0006298,GO:0006301,GO:0006302,GO:0006310,GO:0007050,GO:0007281,GO:0008022,GO:0008094,GO:0008340,GO:0008584,GO:0010165,GO:0010224,GO:0016020,GO:0016446,GO:0016447,GO:0016887,GO:0019237,GO:0019724,GO:0019899,GO:0019901,GO:0030183,GO:0030983,GO:0031573,GO:0032137,GO:0032139,GO:0032142,GO:0032143,GO:0032181,GO:0032300,GO:0032301,GO:0032302,GO:0032357,GO:0032405,GO:0042771,GO:0042803,GO:0043524,GO:0043531,GO:0043570,GO:0045190,GO:0045910,GO:0048298,GO:0048304,GO:0051096,GO:0071168" "magnesium ion binding|four-way junction DNA binding|double-strand/single-strand DNA junction binding|chromosome, telomeric region|in utero embryonic development|somatic recombination of immunoglobulin genes involved in immune response|DNA binding|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|oxidative phosphorylation|DNA repair|mismatch repair|postreplication repair|double-strand break repair|DNA recombination|cell cycle arrest|germ cell development|protein C-terminus binding|DNA-dependent ATPase activity|determination of adult lifespan|male gonad development|response to X-ray|response to UV-B|membrane|somatic hypermutation of immunoglobulin genes|somatic recombination of immunoglobulin gene segments|ATPase activity|centromeric DNA binding|B cell mediated immunity|enzyme binding|protein kinase binding|B cell differentiation|mismatched DNA binding|intra-S DNA damage checkpoint|guanine/thymine mispair binding|dinucleotide insertion or deletion binding|single guanine insertion binding|single thymine insertion binding|dinucleotide repeat insertion binding|mismatch repair complex|MutSalpha complex|MutSbeta complex|oxidized purine DNA binding|MutLalpha complex binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|protein homodimerization activity|negative regulation of neuron apoptotic process|ADP binding|maintenance of DNA repeat elements|isotype switching|negative regulation of DNA recombination|positive regulation of isotype switching to IgA isotypes|positive regulation of isotype switching to IgG isotypes|positive regulation of helicase activity|protein localization to chromatin" "hsa01524,hsa03430,hsa05200,hsa05210" Platinum drug resistance|Mismatch repair|Pathways in cancer|Colorectal cancer MSH3 722.3791961 719.6037816 725.1546106 1.00771373 0.011085858 0.980550412 1 8.202879344 8.622226534 4437 mutS homolog 3 "GO:0000710,GO:0000735,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0006298,GO:0006312,GO:0007131,GO:0008094,GO:0016020,GO:0016447,GO:0019899,GO:0030983,GO:0032135,GO:0032137,GO:0032139,GO:0032142,GO:0032181,GO:0032300,GO:0032302,GO:0032357,GO:0042803,GO:0043111,GO:0043570,GO:0045910,GO:0051096" meiotic mismatch repair|removal of nonhomologous ends|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|mismatch repair|mitotic recombination|reciprocal meiotic recombination|DNA-dependent ATPase activity|membrane|somatic recombination of immunoglobulin gene segments|enzyme binding|mismatched DNA binding|DNA insertion or deletion binding|guanine/thymine mispair binding|dinucleotide insertion or deletion binding|single guanine insertion binding|dinucleotide repeat insertion binding|mismatch repair complex|MutSbeta complex|oxidized purine DNA binding|protein homodimerization activity|replication fork arrest|maintenance of DNA repeat elements|negative regulation of DNA recombination|positive regulation of helicase activity "hsa01524,hsa03430,hsa05200,hsa05210" Platinum drug resistance|Mismatch repair|Pathways in cancer|Colorectal cancer MSH4 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.047159577 0 4438 mutS homolog 4 "GO:0000710,GO:0000712,GO:0000795,GO:0001541,GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0005713,GO:0007129,GO:0007131,GO:0007283,GO:0007292,GO:0008094,GO:0030983" meiotic mismatch repair|resolution of meiotic recombination intermediates|synaptonemal complex|ovarian follicle development|DNA binding|protein binding|ATP binding|nucleus|chromosome|recombination nodule|homologous chromosome pairing at meiosis|reciprocal meiotic recombination|spermatogenesis|female gamete generation|DNA-dependent ATPase activity|mismatched DNA binding MSH5 340.9781925 342.0401613 339.9162237 0.993790385 -0.008986511 0.991560473 1 6.242568478 6.471039272 4439 mutS homolog 5 "GO:0000228,GO:0000710,GO:0005515,GO:0005524,GO:0007131,GO:0008094,GO:0030983" nuclear chromosome|meiotic mismatch repair|protein binding|ATP binding|reciprocal meiotic recombination|DNA-dependent ATPase activity|mismatched DNA binding MSH6 1858.211419 1987.283786 1729.139051 0.870101725 -0.200744016 0.536088479 1 21.51997286 19.53114385 2956 mutS homolog 6 "GO:0000287,GO:0000400,GO:0000710,GO:0000785,GO:0003682,GO:0003690,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006281,GO:0006290,GO:0006298,GO:0008094,GO:0008340,GO:0008630,GO:0009411,GO:0016032,GO:0016446,GO:0016447,GO:0016887,GO:0019899,GO:0030983,GO:0032137,GO:0032142,GO:0032143,GO:0032300,GO:0032301,GO:0032357,GO:0032405,GO:0035064,GO:0036297,GO:0042803,GO:0043231,GO:0043531,GO:0043570,GO:0045190,GO:0045910,GO:0051096,GO:0097193" magnesium ion binding|four-way junction DNA binding|meiotic mismatch repair|chromatin|chromatin binding|double-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|DNA repair|pyrimidine dimer repair|mismatch repair|DNA-dependent ATPase activity|determination of adult lifespan|intrinsic apoptotic signaling pathway in response to DNA damage|response to UV|viral process|somatic hypermutation of immunoglobulin genes|somatic recombination of immunoglobulin gene segments|ATPase activity|enzyme binding|mismatched DNA binding|guanine/thymine mispair binding|single guanine insertion binding|single thymine insertion binding|mismatch repair complex|MutSalpha complex|oxidized purine DNA binding|MutLalpha complex binding|methylated histone binding|interstrand cross-link repair|protein homodimerization activity|intracellular membrane-bounded organelle|ADP binding|maintenance of DNA repeat elements|isotype switching|negative regulation of DNA recombination|positive regulation of helicase activity|intrinsic apoptotic signaling pathway "hsa01524,hsa03430,hsa05200,hsa05210" Platinum drug resistance|Mismatch repair|Pathways in cancer|Colorectal cancer MSI2 797.1269175 878.9518686 715.3019664 0.813812442 -0.297231758 0.419305215 1 2.481233565 2.106240224 124540 musashi RNA binding protein 2 "GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0005844,GO:0042802,GO:0043231" RNA binding|protein binding|cytoplasm|cytosol|polysome|identical protein binding|intracellular membrane-bounded organelle hsa03015 mRNA surveillance pathway MSL1 2544.895933 2354.697847 2735.09402 1.161547765 0.216048481 0.498372308 1 20.86739091 25.28256631 339287 MSL complex subunit 1 "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0016607,GO:0043984,GO:0072487" chromatin binding|protein binding|nucleus|nucleoplasm|nuclear speck|histone H4-K16 acetylation|MSL complex MSL2 478.9043244 476.0143492 481.7942997 1.012142387 0.017412261 0.971958661 1 4.044362944 4.269801301 55167 MSL complex subunit 2 "GO:0005654,GO:0016567,GO:0043984,GO:0046872,GO:0061630,GO:0072487" nucleoplasm|protein ubiquitination|histone H4-K16 acetylation|metal ion binding|ubiquitin protein ligase activity|MSL complex MSL3 1142.934439 944.9240066 1340.944871 1.419103401 0.504979713 0.143172624 1 17.71172 26.21746569 10943 MSL complex subunit 3 "GO:0000123,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006342,GO:0006355,GO:0016573,GO:0016575,GO:0035064,GO:0035267,GO:0043967,GO:0043968,GO:0043984,GO:0046972,GO:0072487" "histone acetyltransferase complex|DNA binding|protein binding|nucleus|nucleoplasm|chromatin silencing|regulation of transcription, DNA-templated|histone acetylation|histone deacetylation|methylated histone binding|NuA4 histone acetyltransferase complex|histone H4 acetylation|histone H2A acetylation|histone H4-K16 acetylation|histone acetyltransferase activity (H4-K16 specific)|MSL complex" MSLN 515.2457848 400.9076075 629.5839622 1.570396646 0.651128997 0.108813722 1 9.129746404 14.95491687 10232 mesothelin "GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0005886,GO:0007155,GO:0007160,GO:0009986,GO:0016020,GO:0031016,GO:0031225,GO:0043687,GO:0044267" protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|plasma membrane|cell adhesion|cell-matrix adhesion|cell surface|membrane|pancreas development|anchored component of membrane|post-translational protein modification|cellular protein metabolic process MSMO1 503.9328114 368.4290165 639.4366063 1.735576129 0.795414649 0.051781495 1 8.049883497 14.57300766 6307 methylsterol monooxygenase 1 "GO:0000254,GO:0005506,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006631,GO:0006695,GO:0008202,GO:0016020,GO:0016021,GO:0016126,GO:0016491,GO:0055114" C-4 methylsterol oxidase activity|iron ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|fatty acid metabolic process|cholesterol biosynthetic process|steroid metabolic process|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity|oxidation-reduction process hsa00100 Steroid biosynthesis MSMP 7.000771347 7.104691779 6.896850916 0.970745971 -0.042834281 1 1 0.531503065 0.538179684 692094 "microseminoprotein, prostate associated" "GO:0002548,GO:0003674,GO:0005125,GO:0005615,GO:0005737,GO:0006954,GO:0007165,GO:0031727,GO:0048247" monocyte chemotaxis|molecular_function|cytokine activity|extracellular space|cytoplasm|inflammatory response|signal transduction|CCR2 chemokine receptor binding|lymphocyte chemotaxis MSN 12376.8251 16801.5811 7952.069106 0.473292904 -1.079194804 0.001863312 0.135055239 184.9067384 91.28484046 4478 moesin "GO:0001771,GO:0001931,GO:0003725,GO:0003779,GO:0005102,GO:0005200,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005902,GO:0005925,GO:0007010,GO:0007159,GO:0008360,GO:0008361,GO:0009986,GO:0010628,GO:0016032,GO:0016323,GO:0016324,GO:0019899,GO:0019901,GO:0022612,GO:0022614,GO:0030175,GO:0031143,GO:0031528,GO:0031982,GO:0035722,GO:0042098,GO:0045177,GO:0045198,GO:0048471,GO:0050839,GO:0050900,GO:0061028,GO:0070062,GO:0070489,GO:0071394,GO:0071803,GO:0071944,GO:0072562,GO:0072678,GO:1902115,GO:1902966,GO:1903364,GO:2000401,GO:2000643" immunological synapse formation|uropod|double-stranded RNA binding|actin binding|signaling receptor binding|structural constituent of cytoskeleton|protein binding|extracellular space|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|microvillus|focal adhesion|cytoskeleton organization|leukocyte cell-cell adhesion|regulation of cell shape|regulation of cell size|cell surface|positive regulation of gene expression|viral process|basolateral plasma membrane|apical plasma membrane|enzyme binding|protein kinase binding|gland morphogenesis|membrane to membrane docking|filopodium|pseudopodium|microvillus membrane|vesicle|interleukin-12-mediated signaling pathway|T cell proliferation|apical part of cell|establishment of epithelial cell apical/basal polarity|perinuclear region of cytoplasm|cell adhesion molecule binding|leukocyte migration|establishment of endothelial barrier|extracellular exosome|T cell aggregation|cellular response to testosterone stimulus|positive regulation of podosome assembly|cell periphery|blood microparticle|T cell migration|regulation of organelle assembly|positive regulation of protein localization to early endosome|positive regulation of cellular protein catabolic process|regulation of lymphocyte migration|positive regulation of early endosome to late endosome transport "hsa04530,hsa04670,hsa04810,hsa05162,hsa05205" Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Measles|Proteoglycans in cancer MSR1 112.6885663 58.86744617 166.5096864 2.828552914 1.50006416 0.023355767 0.672110538 0.546449501 1.612242149 4481 macrophage scavenger receptor 1 "GO:0001540,GO:0005044,GO:0005515,GO:0005581,GO:0005886,GO:0005887,GO:0006898,GO:0006911,GO:0009897,GO:0010629,GO:0010744,GO:0010886,GO:0016021,GO:0030169,GO:0030301,GO:0030666,GO:0034362,GO:0034381,GO:0038024,GO:0097242" "amyloid-beta binding|scavenger receptor activity|protein binding|collagen trimer|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|phagocytosis, engulfment|external side of plasma membrane|negative regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol storage|integral component of membrane|low-density lipoprotein particle binding|cholesterol transport|endocytic vesicle membrane|low-density lipoprotein particle|plasma lipoprotein particle clearance|cargo receptor activity|amyloid-beta clearance" hsa04145 Phagosome MSRA 196.5790562 136.0040998 257.1540127 1.890781331 0.918982525 0.091043718 1 1.725482931 3.40304665 4482 methionine sulfoxide reductase A "GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006464,GO:0006555,GO:0006979,GO:0008113,GO:0015629,GO:0030091,GO:0034599,GO:0036456,GO:0055114,GO:0070062" protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|cellular protein modification process|methionine metabolic process|response to oxidative stress|peptide-methionine (S)-S-oxide reductase activity|actin cytoskeleton|protein repair|cellular response to oxidative stress|L-methionine-(S)-S-oxide reductase activity|oxidation-reduction process|extracellular exosome MSRB1 380.4251417 445.5656701 315.2846133 0.707605263 -0.498983316 0.256988884 1 17.67136204 13.04298542 51734 methionine sulfoxide reductase B1 "GO:0003779,GO:0005515,GO:0005575,GO:0005634,GO:0005829,GO:0008270,GO:0015629,GO:0030041,GO:0030091,GO:0033743,GO:0033745,GO:0045087,GO:0055114" actin binding|protein binding|cellular_component|nucleus|cytosol|zinc ion binding|actin cytoskeleton|actin filament polymerization|protein repair|peptide-methionine (R)-S-oxide reductase activity|L-methionine-(R)-S-oxide reductase activity|innate immune response|oxidation-reduction process MSRB2 283.4644336 283.1727152 283.756152 1.002060357 0.002969408 1 1 7.192426806 7.517704688 22921 methionine sulfoxide reductase B2 "GO:0003779,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006979,GO:0008270,GO:0030041,GO:0030091,GO:0033743,GO:0033745,GO:0055114" actin binding|protein binding|cytoplasm|mitochondrion|cytosol|response to oxidative stress|zinc ion binding|actin filament polymerization|protein repair|peptide-methionine (R)-S-oxide reductase activity|L-methionine-(R)-S-oxide reductase activity|oxidation-reduction process MSRB3 1858.280696 1318.427803 2398.13359 1.818934328 0.863093456 0.008090257 0.370457244 12.55617094 23.82265541 253827 methionine sulfoxide reductase B3 "GO:0005515,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0006979,GO:0008270,GO:0030091,GO:0033743,GO:0033745,GO:0055114" protein binding|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|response to oxidative stress|zinc ion binding|protein repair|peptide-methionine (R)-S-oxide reductase activity|L-methionine-(R)-S-oxide reductase activity|oxidation-reduction process MSS51 49.45349431 46.68797455 52.21901408 1.118468183 0.161524217 0.871391991 1 0.975889891 1.138519264 118490 MSS51 mitochondrial translational activator "GO:0005515,GO:0046872" protein binding|metal ion binding MST1 182.5572246 187.7668541 177.347595 0.944509593 -0.082362645 0.891565868 1 3.014177103 2.969552921 4485 macrophage stimulating 1 "GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0010758,GO:0030971,GO:0033601,GO:0035978,GO:0045721,GO:0048012,GO:0062023,GO:2000479" serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|proteolysis|regulation of macrophage chemotaxis|receptor tyrosine kinase binding|positive regulation of mammary gland epithelial cell proliferation|histone H2A-S139 phosphorylation|negative regulation of gluconeogenesis|hepatocyte growth factor receptor signaling pathway|collagen-containing extracellular matrix|regulation of cAMP-dependent protein kinase activity hsa04020 Calcium signaling pathway MST1R 389.8972389 352.189721 427.6047568 1.214131848 0.279925099 0.523524418 1 3.521651909 4.459931698 4486 macrophage stimulating 1 receptor "GO:0001725,GO:0004714,GO:0005011,GO:0005515,GO:0005524,GO:0005773,GO:0005886,GO:0005887,GO:0006909,GO:0006952,GO:0007165,GO:0007169,GO:0007275,GO:0007338,GO:0007399,GO:0008284,GO:0009615,GO:0009925,GO:0009986,GO:0016477,GO:0018108,GO:0019899,GO:0033674,GO:0038145,GO:0043235,GO:0043406,GO:0045087,GO:0048012,GO:0051897" stress fiber|transmembrane receptor protein tyrosine kinase activity|macrophage colony-stimulating factor receptor activity|protein binding|ATP binding|vacuole|plasma membrane|integral component of plasma membrane|phagocytosis|defense response|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|single fertilization|nervous system development|positive regulation of cell population proliferation|response to virus|basal plasma membrane|cell surface|cell migration|peptidyl-tyrosine phosphorylation|enzyme binding|positive regulation of kinase activity|macrophage colony-stimulating factor signaling pathway|receptor complex|positive regulation of MAP kinase activity|innate immune response|hepatocyte growth factor receptor signaling pathway|positive regulation of protein kinase B signaling hsa04020 Calcium signaling pathway MSTO1 364.9956829 367.4140606 362.5773053 0.986835683 -0.019118212 0.972550415 1 6.549885958 6.742089491 55154 misato mitochondrial distribution and morphology regulator 1 "GO:0003674,GO:0005515,GO:0005737,GO:0005741,GO:0005829,GO:0007005,GO:0048311" molecular_function|protein binding|cytoplasm|mitochondrial outer membrane|cytosol|mitochondrion organization|mitochondrion distribution MSX1 404.242956 356.2495449 452.2363672 1.269437038 0.344188842 0.427082605 1 9.300403441 12.31484311 4487 msh homeobox 1 "GO:0000122,GO:0000785,GO:0000902,GO:0000977,GO:0000981,GO:0000987,GO:0001227,GO:0001228,GO:0001701,GO:0002039,GO:0003198,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007517,GO:0008285,GO:0009952,GO:0010463,GO:0021983,GO:0023019,GO:0030308,GO:0030513,GO:0030901,GO:0034504,GO:0035115,GO:0035116,GO:0035880,GO:0042474,GO:0042475,GO:0042481,GO:0043066,GO:0043517,GO:0045944,GO:0048598,GO:0048863,GO:0050821,GO:0051154,GO:0060021,GO:0060325,GO:0060349,GO:0060536,GO:0061180,GO:0061312,GO:0071316,GO:0090427,GO:1902255,GO:1990837,GO:2000678,GO:2001055" "negative regulation of transcription by RNA polymerase II|chromatin|cell morphogenesis|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|p53 binding|epithelial to mesenchymal transition involved in endocardial cushion formation|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|muscle organ development|negative regulation of cell population proliferation|anterior/posterior pattern specification|mesenchymal cell proliferation|pituitary gland development|signal transduction involved in regulation of gene expression|negative regulation of cell growth|positive regulation of BMP signaling pathway|midbrain development|protein localization to nucleus|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic nail plate morphogenesis|middle ear morphogenesis|odontogenesis of dentin-containing tooth|regulation of odontogenesis|negative regulation of apoptotic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of transcription by RNA polymerase II|embryonic morphogenesis|stem cell differentiation|protein stabilization|negative regulation of striated muscle cell differentiation|roof of mouth development|face morphogenesis|bone morphogenesis|cartilage morphogenesis|mammary gland epithelium development|BMP signaling pathway involved in heart development|cellular response to nicotine|activation of meiosis|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|sequence-specific double-stranded DNA binding|negative regulation of transcription regulatory region DNA binding|positive regulation of mesenchymal cell apoptotic process" hsa05166 Human T-cell leukemia virus 1 infection Homeobox MT1E 2837.118383 2697.752964 2976.483802 1.10331963 0.141850798 0.656338807 1 343.2956546 395.0804876 4493 metallothionein 1E "GO:0005515,GO:0005634,GO:0005737,GO:0006882,GO:0008270,GO:0010273,GO:0045926,GO:0046872,GO:0071276,GO:0071280,GO:0071294" protein binding|nucleus|cytoplasm|cellular zinc ion homeostasis|zinc ion binding|detoxification of copper ion|negative regulation of growth|metal ion binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion hsa04978 Mineral absorption MT1F 84.33586324 107.5853326 61.08639383 0.567794813 -0.816558425 0.255998758 1 12.8207472 7.593127411 4494 metallothionein 1F "GO:0005515,GO:0005634,GO:0005737,GO:0006882,GO:0008270,GO:0010273,GO:0045926,GO:0046872,GO:0071276,GO:0071280,GO:0071294" protein binding|nucleus|cytoplasm|cellular zinc ion homeostasis|zinc ion binding|detoxification of copper ion|negative regulation of growth|metal ion binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion hsa04978 Mineral absorption MT1M 75.81537954 63.94222601 87.68853307 1.371371292 0.455619226 0.545940087 1 8.136804454 11.63924641 4499 metallothionein 1M "GO:0005515,GO:0005634,GO:0005737,GO:0006882,GO:0008270,GO:0010273,GO:0045926,GO:0046872,GO:0071276,GO:0071280,GO:0071294" protein binding|nucleus|cytoplasm|cellular zinc ion homeostasis|zinc ion binding|detoxification of copper ion|negative regulation of growth|metal ion binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion hsa04978 Mineral absorption MT1X 117.069554 156.3032191 77.83588891 0.497980076 -1.005840074 0.119099492 1 19.5945709 10.1780283 4501 metallothionein 1X "GO:0005515,GO:0005634,GO:0005737,GO:0006882,GO:0008270,GO:0010038,GO:0010273,GO:0036018,GO:0045926,GO:0046872,GO:0071276,GO:0071280,GO:0071294" protein binding|nucleus|cytoplasm|cellular zinc ion homeostasis|zinc ion binding|response to metal ion|detoxification of copper ion|cellular response to erythropoietin|negative regulation of growth|metal ion binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion hsa04978 Mineral absorption MT2A 8189.153143 6508.912625 9869.393661 1.516289161 0.600544906 0.070541289 1 822.0784598 1300.203195 4502 metallothionein 2A "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006878,GO:0006882,GO:0008270,GO:0010038,GO:0010273,GO:0036016,GO:0036018,GO:0045926,GO:0046872,GO:0060333,GO:0071276,GO:0071280,GO:0071294" protein binding|nucleus|cytoplasm|cytosol|cellular copper ion homeostasis|cellular zinc ion homeostasis|zinc ion binding|response to metal ion|detoxification of copper ion|cellular response to interleukin-3|cellular response to erythropoietin|negative regulation of growth|metal ion binding|interferon-gamma-mediated signaling pathway|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion hsa04978 Mineral absorption MTA1 1971.112031 1824.890831 2117.333231 1.160251997 0.214438181 0.506558206 1 20.3041043 24.57265538 9112 metastasis associated 1 "GO:0000122,GO:0000978,GO:0001103,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0006302,GO:0007165,GO:0008270,GO:0010212,GO:0016575,GO:0016581,GO:0032922,GO:0040029,GO:0042826,GO:0043153,GO:0043161,GO:0043231,GO:0045475,GO:0045893,GO:1902499" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|cytosol|microtubule|double-strand break repair|signal transduction|zinc ion binding|response to ionizing radiation|histone deacetylation|NuRD complex|circadian regulation of gene expression|regulation of gene expression, epigenetic|histone deacetylase binding|entrainment of circadian clock by photoperiod|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|locomotor rhythm|positive regulation of transcription, DNA-templated|positive regulation of protein autoubiquitination" MTA2 2618.97139 2703.8427 2534.100079 0.93722171 -0.093537721 0.769943069 1 41.35913445 40.43241772 9219 metastasis associated 1 family member 2 "GO:0000118,GO:0000122,GO:0000785,GO:0001085,GO:0001103,GO:0003713,GO:0003714,GO:0004407,GO:0005515,GO:0005654,GO:0005667,GO:0006306,GO:0006333,GO:0008270,GO:0010762,GO:0016020,GO:0016575,GO:0016581,GO:0031492,GO:0032991,GO:0042826,GO:0043044,GO:0043565,GO:0045944,GO:1901796" histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription factor binding|RNA polymerase II repressing transcription factor binding|transcription coactivator activity|transcription corepressor activity|histone deacetylase activity|protein binding|nucleoplasm|transcription regulator complex|DNA methylation|chromatin assembly or disassembly|zinc ion binding|regulation of fibroblast migration|membrane|histone deacetylation|NuRD complex|nucleosomal DNA binding|protein-containing complex|histone deacetylase binding|ATP-dependent chromatin remodeling|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|regulation of signal transduction by p53 class mediator MTA3 696.2993806 721.6336935 670.9650677 0.929786225 -0.105029043 0.784042189 1 4.049662139 3.927514791 57504 metastasis associated 1 family member 3 "GO:0000122,GO:0001103,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005654,GO:0005737,GO:0008270,GO:0008284,GO:0010971,GO:0016575,GO:0016581,GO:0042826,GO:0043231,GO:0043565,GO:0044877,GO:0045892,GO:0045893" "negative regulation of transcription by RNA polymerase II|RNA polymerase II repressing transcription factor binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleoplasm|cytoplasm|zinc ion binding|positive regulation of cell population proliferation|positive regulation of G2/M transition of mitotic cell cycle|histone deacetylation|NuRD complex|histone deacetylase binding|intracellular membrane-bounded organelle|sequence-specific DNA binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated" zf-GATA MTAP 1194.037052 1272.754784 1115.31932 0.87630338 -0.190497671 0.57871567 1 10.68642901 9.767940868 4507 methylthioadenosine phosphorylase "GO:0004645,GO:0005515,GO:0005654,GO:0005829,GO:0006139,GO:0006166,GO:0006738,GO:0017061,GO:0019509,GO:0033574,GO:0035722,GO:0070062" "1,4-alpha-oligoglucan phosphorylase activity|protein binding|nucleoplasm|cytosol|nucleobase-containing compound metabolic process|purine ribonucleoside salvage|nicotinamide riboside catabolic process|S-methyl-5-thioadenosine phosphorylase activity|L-methionine salvage from methylthioadenosine|response to testosterone|interleukin-12-mediated signaling pathway|extracellular exosome" hsa00270 Cysteine and methionine metabolism MTARC1 234.8329001 225.320225 244.3455753 1.08443694 0.116946163 0.826213924 1 3.439323241 3.890390777 64757 mitochondrial amidoxime reducing component 1 "GO:0005515,GO:0005739,GO:0005741,GO:0006805,GO:0006809,GO:0008940,GO:0016021,GO:0016661,GO:0030151,GO:0030170,GO:0042126,GO:0043546,GO:0050421,GO:0051410,GO:0055114,GO:0070458,GO:0098809,GO:1903958" "protein binding|mitochondrion|mitochondrial outer membrane|xenobiotic metabolic process|nitric oxide biosynthetic process|nitrate reductase activity|integral component of membrane|oxidoreductase activity, acting on other nitrogenous compounds as donors|molybdenum ion binding|pyridoxal phosphate binding|nitrate metabolic process|molybdopterin cofactor binding|nitrite reductase (NO-forming) activity|detoxification of nitrogen compound|oxidation-reduction process|cellular detoxification of nitrogen compound|nitrite reductase activity|nitric-oxide synthase complex" MTARC2 233.3280336 189.7967661 276.859301 1.458714533 0.544697579 0.288686364 1 4.314423985 6.564611985 54996 mitochondrial amidoxime reducing component 2 "GO:0005739,GO:0005741,GO:0005777,GO:0006805,GO:0006809,GO:0008940,GO:0016661,GO:0030151,GO:0030170,GO:0042126,GO:0043546,GO:0051410,GO:0055114,GO:0070458,GO:0098809" "mitochondrion|mitochondrial outer membrane|peroxisome|xenobiotic metabolic process|nitric oxide biosynthetic process|nitrate reductase activity|oxidoreductase activity, acting on other nitrogenous compounds as donors|molybdenum ion binding|pyridoxal phosphate binding|nitrate metabolic process|molybdopterin cofactor binding|detoxification of nitrogen compound|oxidation-reduction process|cellular detoxification of nitrogen compound|nitrite reductase activity" MTBP 643.0466054 583.5996818 702.493529 1.203725003 0.267505839 0.487976643 1 6.179649816 7.759023672 27085 MDM2 binding protein "GO:0000776,GO:0000785,GO:0007050,GO:0007089,GO:0008285,GO:0031396,GO:0034501,GO:0045839" kinetochore|chromatin|cell cycle arrest|traversing start control point of mitotic cell cycle|negative regulation of cell population proliferation|regulation of protein ubiquitination|protein localization to kinetochore|negative regulation of mitotic nuclear division MTCH1 3715.760466 3491.448531 3940.072402 1.128492191 0.174396435 0.584016621 1 59.47849008 70.01231253 23787 mitochondrial carrier 1 "GO:0005515,GO:0005739,GO:0005743,GO:0006915,GO:0006919,GO:0009966,GO:0016020,GO:0016021,GO:0043065,GO:0045161" protein binding|mitochondrion|mitochondrial inner membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of signal transduction|membrane|integral component of membrane|positive regulation of apoptotic process|neuronal ion channel clustering MTCH2 2175.475717 2425.744764 1925.20667 0.793655911 -0.333414432 0.298488463 1 27.48443284 22.75280601 23788 mitochondrial carrier 2 "GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0016020,GO:0016021,GO:0043065,GO:0070585" protein binding|nucleus|mitochondrion|mitochondrial inner membrane|membrane|integral component of membrane|positive regulation of apoptotic process|protein localization to mitochondrion MTCL1 846.3928599 845.4583217 847.3273982 1.002210726 0.003185883 0.996730305 1 3.351556152 3.503656136 23255 microtubule crosslinking factor 1 "GO:0000922,GO:0001578,GO:0003723,GO:0005615,GO:0005737,GO:0005856,GO:0008017,GO:0010506,GO:0016324,GO:0016327,GO:0016328,GO:0030496,GO:0042803,GO:0045197,GO:0090314,GO:0097427,GO:2000576" spindle pole|microtubule bundle formation|RNA binding|extracellular space|cytoplasm|cytoskeleton|microtubule binding|regulation of autophagy|apical plasma membrane|apicolateral plasma membrane|lateral plasma membrane|midbody|protein homodimerization activity|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of protein targeting to membrane|microtubule bundle|positive regulation of microtubule motor activity MTCP1 57.90247073 51.76275439 64.04218708 1.237225257 0.30710819 0.718338636 1 1.200366713 1.549097134 4515 mature T cell proliferation 1 "GO:0019901,GO:0032991,GO:0033138,GO:0043539,GO:0071902" protein kinase binding|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity hsa04151 PI3K-Akt signaling pathway MTDH 6647.8094 6717.993555 6577.625245 0.97910562 -0.030463597 0.926079644 1 42.72258587 43.63178741 92140 metadherin "GO:0000122,GO:0001085,GO:0001650,GO:0003712,GO:0003713,GO:0003723,GO:0003725,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005923,GO:0006357,GO:0010508,GO:0016021,GO:0016324,GO:0016604,GO:0031663,GO:0031965,GO:0043066,GO:0043123,GO:0045766,GO:0045893,GO:0046581,GO:0048471,GO:0051059,GO:0051092,GO:0051897,GO:0070830" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|fibrillar center|transcription coregulator activity|transcription coactivator activity|RNA binding|double-stranded RNA binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|bicellular tight junction|regulation of transcription by RNA polymerase II|positive regulation of autophagy|integral component of membrane|apical plasma membrane|nuclear body|lipopolysaccharide-mediated signaling pathway|nuclear membrane|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|intercellular canaliculus|perinuclear region of cytoplasm|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling|bicellular tight junction assembly" MTERF1 185.9908042 186.7518982 185.2297103 0.991849144 -0.011807386 0.994046044 1 2.342329079 2.423312723 7978 mitochondrial transcription termination factor 1 "GO:0003676,GO:0003690,GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0006353,GO:0006355,GO:0006393,GO:0007005,GO:0032392,GO:0042645" "nucleic acid binding|double-stranded DNA binding|RNA binding|protein binding|mitochondrion|mitochondrial matrix|DNA-templated transcription, termination|regulation of transcription, DNA-templated|termination of mitochondrial transcription|mitochondrion organization|DNA geometric change|mitochondrial nucleoid" MTERF2 144.1225097 119.7648043 168.4802152 1.406758991 0.492375184 0.414284029 1 0.961735347 1.411208577 80298 mitochondrial transcription termination factor 2 "GO:0003676,GO:0003677,GO:0003690,GO:0005515,GO:0005739,GO:0005759,GO:0006355,GO:0006393,GO:0042645" "nucleic acid binding|DNA binding|double-stranded DNA binding|protein binding|mitochondrion|mitochondrial matrix|regulation of transcription, DNA-templated|termination of mitochondrial transcription|mitochondrial nucleoid" MTERF3 601.4819074 638.4073041 564.5565107 0.884320256 -0.177359159 0.652060385 1 19.56024065 18.0426239 51001 mitochondrial transcription termination factor 3 "GO:0000976,GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0016236,GO:0045892,GO:0061668" "transcription regulatory region sequence-specific DNA binding|protein binding|mitochondrion|mitochondrial outer membrane|cytosol|macroautophagy|negative regulation of transcription, DNA-templated|mitochondrial ribosome assembly" MTERF4 396.1030193 405.9823873 386.2236513 0.951331051 -0.071980627 0.873918584 1 2.631376465 2.611142587 130916 mitochondrial transcription termination factor 4 "GO:0003690,GO:0005515,GO:0005739,GO:0005759,GO:0005762,GO:0005829,GO:0006355,GO:0006390,GO:0006626,GO:0007507,GO:0019843,GO:0031167,GO:0042255,GO:0043010" "double-stranded DNA binding|protein binding|mitochondrion|mitochondrial matrix|mitochondrial large ribosomal subunit|cytosol|regulation of transcription, DNA-templated|mitochondrial transcription|protein targeting to mitochondrion|heart development|rRNA binding|rRNA methylation|ribosome assembly|camera-type eye development" MTF1 466.1498269 547.061267 385.2383869 0.704196057 -0.505950947 0.224074174 1 3.122939952 2.293892979 4520 metal regulatory transcription factor 1 "GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006357,GO:0006979,GO:0007417,GO:0010038,GO:0035035,GO:0045944,GO:0046686,GO:0046872,GO:0071294,GO:1990079,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|response to oxidative stress|central nervous system development|response to metal ion|histone acetyltransferase binding|positive regulation of transcription by RNA polymerase II|response to cadmium ion|metal ion binding|cellular response to zinc ion|cartilage homeostasis|sequence-specific double-stranded DNA binding" MTF2 640.4146976 639.4222601 641.4071352 1.00310417 0.004471434 0.995374677 1 8.106253248 8.481684874 22823 metal response element binding transcription factor 2 "GO:0000122,GO:0000977,GO:0001226,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0005925,GO:0006325,GO:0006355,GO:0007379,GO:0019827,GO:0035064,GO:0035098,GO:0045814,GO:0045944,GO:0046872,GO:0048863,GO:0061086,GO:0061087,GO:1990830" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription corepressor binding|DNA binding|chromatin binding|nucleus|nucleoplasm|cytoplasm|focal adhesion|chromatin organization|regulation of transcription, DNA-templated|segment specification|stem cell population maintenance|methylated histone binding|ESC/E(Z) complex|negative regulation of gene expression, epigenetic|positive regulation of transcription by RNA polymerase II|metal ion binding|stem cell differentiation|negative regulation of histone H3-K27 methylation|positive regulation of histone H3-K27 methylation|cellular response to leukemia inhibitory factor" MTFMT 250.2705237 202.9911937 297.5498538 1.465826415 0.551714268 0.27148747 1 3.546322128 5.422214018 123263 mitochondrial methionyl-tRNA formyltransferase "GO:0004479,GO:0005739,GO:0006413,GO:0071951" methionyl-tRNA formyltransferase activity|mitochondrion|translational initiation|conversion of methionyl-tRNA to N-formyl-methionyl-tRNA "hsa00670,hsa00970" One carbon pool by folate|Aminoacyl-tRNA biosynthesis MTFP1 754.9129647 1024.090572 485.7353574 0.474308983 -1.076100904 0.004092017 0.236073713 45.77808888 22.64826497 51537 mitochondrial fission process 1 "GO:0000266,GO:0005515,GO:0005739,GO:0005743,GO:0006915,GO:0014850,GO:0016021" mitochondrial fission|protein binding|mitochondrion|mitochondrial inner membrane|apoptotic process|response to muscle activity|integral component of membrane MTFR1 1084.65934 1069.763591 1099.555089 1.027848675 0.039627879 0.911847542 1 15.18490806 16.28010782 9650 mitochondrial fission regulator 1 "GO:0000266,GO:0005515,GO:0005739,GO:0005829,GO:0005886,GO:0007005,GO:0009060" mitochondrial fission|protein binding|mitochondrion|cytosol|plasma membrane|mitochondrion organization|aerobic respiration MTFR1L 711.7815415 702.3495301 721.2135529 1.026858454 0.038237329 0.922855375 1 15.28643144 16.37316452 56181 mitochondrial fission regulator 1 like "GO:0000266,GO:0005515,GO:0005739,GO:0009060" mitochondrial fission|protein binding|mitochondrion|aerobic respiration MTFR2 123.6573652 101.4955968 145.8191336 1.436704036 0.522762895 0.410261087 1 2.715474868 4.069387337 113115 mitochondrial fission regulator 2 "GO:0000266,GO:0005515,GO:0005739,GO:0007005,GO:0009060" mitochondrial fission|protein binding|mitochondrion|mitochondrion organization|aerobic respiration MTG1 499.0995234 509.5078961 488.6911506 0.959143429 -0.060181525 0.887621265 1 7.536442028 7.539904556 92170 mitochondrial ribosome associated GTPase 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005743,GO:0005759,GO:0005761,GO:0044065,GO:0070129" GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial ribosome|regulation of respiratory system process|regulation of mitochondrial translation MTG2 1530.748817 1760.948605 1300.54903 0.738550248 -0.437232014 0.186319133 1 11.67965356 8.997584611 26164 mitochondrial ribosome associated GTPase 2 "GO:0000287,GO:0003924,GO:0005525,GO:0005739,GO:0005743,GO:0005759,GO:0005761,GO:0042254,GO:0044065,GO:0070129" magnesium ion binding|GTPase activity|GTP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial ribosome|ribosome biogenesis|regulation of respiratory system process|regulation of mitochondrial translation MTHFD1 3755.558025 4056.779006 3454.337044 0.851497466 -0.231925858 0.46644318 1 65.14316588 57.85863061 4522 "methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1" "GO:0000105,GO:0001843,GO:0004329,GO:0004477,GO:0004486,GO:0004487,GO:0004488,GO:0005515,GO:0005524,GO:0005739,GO:0005829,GO:0006164,GO:0006555,GO:0006730,GO:0007507,GO:0009069,GO:0009070,GO:0009086,GO:0009257,GO:0016020,GO:0035999,GO:0046655,GO:0048702,GO:0048703,GO:0055114,GO:0061053,GO:0070062" histidine biosynthetic process|neural tube closure|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding|ATP binding|mitochondrion|cytosol|purine nucleotide biosynthetic process|methionine metabolic process|one-carbon metabolic process|heart development|serine family amino acid metabolic process|serine family amino acid biosynthetic process|methionine biosynthetic process|10-formyltetrahydrofolate biosynthetic process|membrane|tetrahydrofolate interconversion|folic acid metabolic process|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|oxidation-reduction process|somite development|extracellular exosome hsa00670 One carbon pool by folate MTHFD1L 927.7135468 948.9838304 906.4432632 0.955172506 -0.066166785 0.85565979 1 3.615094637 3.601781919 25902 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like "GO:0001843,GO:0004329,GO:0004488,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006760,GO:0009257,GO:0015942,GO:0016020,GO:0035999,GO:0042803,GO:0046655,GO:0048702,GO:0048703,GO:0055114" neural tube closure|formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|ATP binding|mitochondrion|mitochondrial matrix|cytosol|folic acid-containing compound metabolic process|10-formyltetrahydrofolate biosynthetic process|formate metabolic process|membrane|tetrahydrofolate interconversion|protein homodimerization activity|folic acid metabolic process|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|oxidation-reduction process hsa00670 One carbon pool by folate MTHFD2 2114.032279 1491.985274 2736.079285 1.833851401 0.874876741 0.006756852 0.334242214 17.06884814 32.6500827 10797 "methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase" "GO:0000287,GO:0004477,GO:0004487,GO:0004488,GO:0005515,GO:0005615,GO:0005739,GO:0005759,GO:0035999,GO:0042301,GO:0046653,GO:0046655,GO:0055114" magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding|extracellular space|mitochondrion|mitochondrial matrix|tetrahydrofolate interconversion|phosphate ion binding|tetrahydrofolate metabolic process|folic acid metabolic process|oxidation-reduction process hsa00670 One carbon pool by folate MTHFD2L 129.6701506 142.0938356 117.2464656 0.825134075 -0.277299535 0.662340008 1 0.858572118 0.738953708 441024 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like "GO:0000105,GO:0004477,GO:0004487,GO:0004488,GO:0005739,GO:0005743,GO:0005759,GO:0006164,GO:0009086,GO:0009256,GO:0035999,GO:0046655,GO:0055114" histidine biosynthetic process|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|purine nucleotide biosynthetic process|methionine biosynthetic process|10-formyltetrahydrofolate metabolic process|tetrahydrofolate interconversion|folic acid metabolic process|oxidation-reduction process hsa00670 One carbon pool by folate MTHFR 716.0667736 692.1999704 739.9335768 1.068959273 0.096206887 0.800892295 1 4.53994905 5.062069081 4524 methylenetetrahydrofolate reductase "GO:0001666,GO:0001843,GO:0004489,GO:0005829,GO:0006555,GO:0009086,GO:0031060,GO:0033274,GO:0035999,GO:0042493,GO:0043200,GO:0044877,GO:0045202,GO:0046500,GO:0046655,GO:0050660,GO:0050661,GO:0050667,GO:0051593,GO:0055114,GO:0070555,GO:0070829,GO:0071949,GO:0072341" response to hypoxia|neural tube closure|methylenetetrahydrofolate reductase (NAD(P)H) activity|cytosol|methionine metabolic process|methionine biosynthetic process|regulation of histone methylation|response to vitamin B2|tetrahydrofolate interconversion|response to drug|response to amino acid|protein-containing complex binding|synapse|S-adenosylmethionine metabolic process|folic acid metabolic process|flavin adenine dinucleotide binding|NADP binding|homocysteine metabolic process|response to folic acid|oxidation-reduction process|response to interleukin-1|heterochromatin maintenance|FAD binding|modified amino acid binding "hsa00670,hsa01523" One carbon pool by folate|Antifolate resistance MTHFS 27.46591585 25.37389921 29.5579325 1.164895165 0.220200125 0.860398291 1 0.529719077 0.643647944 10588 methenyltetrahydrofolate synthetase "GO:0005524,GO:0005542,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006536,GO:0009396,GO:0015942,GO:0030272,GO:0035999,GO:0046653,GO:0046655,GO:0046657,GO:0046872" ATP binding|folic acid binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|glutamate metabolic process|folic acid-containing compound biosynthetic process|formate metabolic process|5-formyltetrahydrofolate cyclo-ligase activity|tetrahydrofolate interconversion|tetrahydrofolate metabolic process|folic acid metabolic process|folic acid catabolic process|metal ion binding hsa00670 One carbon pool by folate MTHFSD 293.4209982 290.277407 296.5645894 1.021659221 0.030914059 0.955945689 1 2.465044706 2.626919647 64779 methenyltetrahydrofolate synthetase domain containing "GO:0003723,GO:0005737" RNA binding|cytoplasm MTIF2 506.8331809 499.3583364 514.3080254 1.029937798 0.04255721 0.921681829 1 4.853336809 5.21395595 4528 mitochondrial translational initiation factor 2 "GO:0003723,GO:0003743,GO:0003924,GO:0005525,GO:0005654,GO:0005739,GO:0006446,GO:0008135,GO:0032790,GO:0043024,GO:0070124" "RNA binding|translation initiation factor activity|GTPase activity|GTP binding|nucleoplasm|mitochondrion|regulation of translational initiation|translation factor activity, RNA binding|ribosome disassembly|ribosomal small subunit binding|mitochondrial translational initiation" MTIF3 277.9888178 245.6193443 310.3582912 1.2635743 0.3375105 0.488030768 1 7.431154897 9.794291558 219402 mitochondrial translational initiation factor 3 "GO:0003743,GO:0005515,GO:0005739,GO:0008135,GO:0032790,GO:0043022,GO:0043024,GO:0070124" "translation initiation factor activity|protein binding|mitochondrion|translation factor activity, RNA binding|ribosome disassembly|ribosome binding|ribosomal small subunit binding|mitochondrial translational initiation" MTLN 211.3971166 206.0360616 216.7581716 1.052039968 0.073189515 0.898761559 1 24.43793833 26.81715695 205251 mitoregulin "GO:0010918,GO:0031305,GO:0031334,GO:0051284" positive regulation of mitochondrial membrane potential|integral component of mitochondrial inner membrane|positive regulation of protein-containing complex assembly|positive regulation of sequestering of calcium ion MTM1 311.0518372 283.1727152 338.9309593 1.196905426 0.259309162 0.581994426 1 1.67094245 2.086110255 4534 myotubularin 1 "GO:0001726,GO:0004438,GO:0004721,GO:0004725,GO:0005515,GO:0005737,GO:0005770,GO:0005829,GO:0005886,GO:0006470,GO:0006661,GO:0008333,GO:0015031,GO:0016020,GO:0019215,GO:0030175,GO:0031674,GO:0032007,GO:0032435,GO:0035091,GO:0035335,GO:0044088,GO:0045109,GO:0046716,GO:0046856,GO:0048311,GO:0048633,GO:0051898,GO:0052629,GO:0070584,GO:1902902" "ruffle|phosphatidylinositol-3-phosphatase activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytoplasm|late endosome|cytosol|plasma membrane|protein dephosphorylation|phosphatidylinositol biosynthetic process|endosome to lysosome transport|protein transport|membrane|intermediate filament binding|filopodium|I band|negative regulation of TOR signaling|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|phosphatidylinositol binding|peptidyl-tyrosine dephosphorylation|regulation of vacuole organization|intermediate filament organization|muscle cell cellular homeostasis|phosphatidylinositol dephosphorylation|mitochondrion distribution|positive regulation of skeletal muscle tissue growth|negative regulation of protein kinase B signaling|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|mitochondrion morphogenesis|negative regulation of autophagosome assembly" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR1 1363.88976 1467.62633 1260.153189 0.858633538 -0.219885569 0.512982419 1 9.875129023 8.844362944 8776 myotubularin related protein 1 "GO:0004438,GO:0004725,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0016020,GO:0035335,GO:0042803,GO:0046856,GO:0052629,GO:0060304" "phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|membrane|peptidyl-tyrosine dephosphorylation|protein homodimerization activity|phosphatidylinositol dephosphorylation|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR10 465.4899318 400.9076075 530.0722561 1.322180588 0.402919238 0.333432938 1 3.556587144 4.905012975 54893 myotubularin related protein 10 "GO:0004438,GO:0005737,GO:0005829,GO:0016020,GO:0046856" phosphatidylinositol-3-phosphatase activity|cytoplasm|cytosol|membrane|phosphatidylinositol dephosphorylation MTMR11 471.3475784 329.8606897 612.8344671 1.857858442 0.893640581 0.031930765 0.799980746 6.022451426 11.67083303 10903 myotubularin related protein 11 "GO:0004438,GO:0005737,GO:0016020,GO:0046856,GO:0070062" phosphatidylinositol-3-phosphatase activity|cytoplasm|membrane|phosphatidylinositol dephosphorylation|extracellular exosome MTMR12 1129.22709 984.5072893 1273.946891 1.293994371 0.371831341 0.281754252 1 9.746251187 13.1548505 54545 myotubularin related protein 12 "GO:0004438,GO:0005515,GO:0005737,GO:0005829,GO:0006661,GO:0016020,GO:0016529,GO:0019208,GO:0030017,GO:0046856,GO:0050790,GO:1901998" phosphatidylinositol-3-phosphatase activity|protein binding|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|membrane|sarcoplasmic reticulum|phosphatase regulator activity|sarcomere|phosphatidylinositol dephosphorylation|regulation of catalytic activity|toxin transport MTMR14 1447.584779 1194.603175 1700.566383 1.42354082 0.509483863 0.126393206 1 21.02238933 31.21532994 64419 myotubularin related protein 14 "GO:0001726,GO:0004438,GO:0004725,GO:0005515,GO:0005829,GO:0006661,GO:0016236,GO:0035335,GO:0048471" ruffle|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytosol|phosphatidylinositol biosynthetic process|macroautophagy|peptidyl-tyrosine dephosphorylation|perinuclear region of cytoplasm "hsa00562,hsa04070,hsa04140" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - animal MTMR2 1229.301452 1225.051854 1233.55105 1.006937825 0.009974605 0.979307107 1 12.5621694 13.19420509 8898 myotubularin related protein 2 "GO:0002091,GO:0004438,GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0005774,GO:0005829,GO:0006470,GO:0006661,GO:0008021,GO:0008138,GO:0014069,GO:0016020,GO:0030424,GO:0030425,GO:0031642,GO:0031901,GO:0032288,GO:0035335,GO:0042802,GO:0043197,GO:0043231,GO:0045806,GO:0046855,GO:0046856,GO:0048471,GO:0048666,GO:0052629,GO:0060304,GO:0070062,GO:0090394,GO:0097060,GO:0097062,GO:2000643,GO:2000645" "negative regulation of receptor internalization|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|vacuolar membrane|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|synaptic vesicle|protein tyrosine/serine/threonine phosphatase activity|postsynaptic density|membrane|axon|dendrite|negative regulation of myelination|early endosome membrane|myelin assembly|peptidyl-tyrosine dephosphorylation|identical protein binding|dendritic spine|intracellular membrane-bounded organelle|negative regulation of endocytosis|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|neuron development|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation|extracellular exosome|negative regulation of excitatory postsynaptic potential|synaptic membrane|dendritic spine maintenance|positive regulation of early endosome to late endosome transport|negative regulation of receptor catabolic process" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR3 1801.503537 1747.754178 1855.252896 1.061506773 0.086113576 0.792276747 1 9.820011469 10.8730327 8897 myotubularin related protein 3 "GO:0004438,GO:0004722,GO:0004725,GO:0005515,GO:0005737,GO:0005829,GO:0006470,GO:0006661,GO:0010506,GO:0016020,GO:0016236,GO:0019898,GO:0019903,GO:0035335,GO:0042149,GO:0046856,GO:0046872,GO:0052629,GO:0060304,GO:1904562,GO:2000785" "phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytoplasm|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|regulation of autophagy|membrane|macroautophagy|extrinsic component of membrane|protein phosphatase binding|peptidyl-tyrosine dephosphorylation|cellular response to glucose starvation|phosphatidylinositol dephosphorylation|metal ion binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation|phosphatidylinositol 5-phosphate metabolic process|regulation of autophagosome assembly" "hsa00562,hsa04070,hsa04140" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - animal MTMR4 1495.90851 1366.130733 1625.686287 1.189993203 0.250953333 0.44956197 1 10.56008886 13.10774498 9110 myotubularin related protein 4 "GO:0004438,GO:0004722,GO:0004725,GO:0005515,GO:0005615,GO:0005737,GO:0005768,GO:0005829,GO:0006470,GO:0006661,GO:0007179,GO:0010506,GO:0014894,GO:0016020,GO:0019903,GO:0030512,GO:0031901,GO:0035335,GO:0046856,GO:0046872,GO:0052629,GO:0060304" "phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|extracellular space|cytoplasm|endosome|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|transforming growth factor beta receptor signaling pathway|regulation of autophagy|response to denervation involved in regulation of muscle adaptation|membrane|protein phosphatase binding|negative regulation of transforming growth factor beta receptor signaling pathway|early endosome membrane|peptidyl-tyrosine dephosphorylation|phosphatidylinositol dephosphorylation|metal ion binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation" "hsa00562,hsa04070,hsa04140" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - animal MTMR6 991.4912315 897.221076 1085.761387 1.210138076 0.275171668 0.43602596 1 8.547983878 10.78982871 9107 myotubularin related protein 6 "GO:0004438,GO:0004722,GO:0004725,GO:0005515,GO:0005635,GO:0005737,GO:0005783,GO:0005793,GO:0005829,GO:0006470,GO:0006661,GO:0006897,GO:0016020,GO:0032587,GO:0035335,GO:0046856,GO:0048471,GO:0052629,GO:0106018" "phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|endocytosis|membrane|ruffle membrane|peptidyl-tyrosine dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3,5-bisphosphate phosphatase activity" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR8 55.96163345 53.79266632 58.13060058 1.080641741 0.111888314 0.913101826 1 1.024213827 1.154485022 55613 myotubularin related protein 8 "GO:0004438,GO:0004725,GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0006661,GO:0010507,GO:0016020,GO:0016241,GO:0035335,GO:0046856,GO:0052629,GO:0106018" "phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|protein binding|nuclear envelope|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|negative regulation of autophagy|membrane|regulation of macroautophagy|peptidyl-tyrosine dephosphorylation|phosphatidylinositol dephosphorylation|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3,5-bisphosphate phosphatase activity" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR9 331.1728073 311.5914823 350.7541323 1.125685881 0.170804304 0.713745205 1 2.06557714 2.425350822 66036 myotubularin related protein 9 "GO:0004438,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0006661,GO:0006897,GO:0010507,GO:0010922,GO:0016020,GO:0019903,GO:0030234,GO:0032587,GO:0032991,GO:0046856,GO:0048471,GO:0050821,GO:0060304" phosphatidylinositol-3-phosphatase activity|protein binding|cytoplasm|endoplasmic reticulum|cytosol|phosphatidylinositol biosynthetic process|endocytosis|negative regulation of autophagy|positive regulation of phosphatase activity|membrane|protein phosphatase binding|enzyme regulator activity|ruffle membrane|protein-containing complex|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|protein stabilization|regulation of phosphatidylinositol dephosphorylation MTO1 404.7328667 389.7430919 419.7226414 1.076921311 0.106912838 0.809266677 1 1.812091496 2.035541792 25821 mitochondrial tRNA translation optimization 1 "GO:0002098,GO:0003723,GO:0005739,GO:0030488,GO:0050660,GO:0070899" tRNA wobble uridine modification|RNA binding|mitochondrion|tRNA methylation|flavin adenine dinucleotide binding|mitochondrial tRNA wobble uridine modification MTOR 3469.987221 3057.047377 3882.927066 1.270155999 0.345005698 0.278322247 1 16.91192409 22.4060868 2475 mechanistic target of rapamycin kinase "GO:0000139,GO:0001002,GO:0001003,GO:0001006,GO:0001156,GO:0001558,GO:0001933,GO:0001938,GO:0002296,GO:0003007,GO:0003179,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005741,GO:0005764,GO:0005765,GO:0005789,GO:0005829,GO:0005979,GO:0006112,GO:0006207,GO:0006468,GO:0007040,GO:0007050,GO:0007281,GO:0007420,GO:0007569,GO:0007584,GO:0007616,GO:0008361,GO:0008542,GO:0009267,GO:0009791,GO:0010507,GO:0010592,GO:0010628,GO:0010718,GO:0010831,GO:0010976,GO:0012505,GO:0014042,GO:0014736,GO:0014823,GO:0016020,GO:0016241,GO:0016242,GO:0016301,GO:0016310,GO:0016605,GO:0018105,GO:0018107,GO:0019901,GO:0019904,GO:0021510,GO:0030163,GO:0030425,GO:0030838,GO:0031397,GO:0031529,GO:0031641,GO:0031667,GO:0031669,GO:0031929,GO:0031931,GO:0031932,GO:0031998,GO:0032095,GO:0032148,GO:0032516,GO:0032868,GO:0032956,GO:0034198,GO:0035176,GO:0035264,GO:0038202,GO:0042060,GO:0042220,GO:0042752,GO:0042802,GO:0043022,GO:0043025,GO:0043087,GO:0043200,GO:0043276,GO:0043278,GO:0043610,GO:0045182,GO:0045335,GO:0045429,GO:0045670,GO:0045727,GO:0045792,GO:0045945,GO:0046777,GO:0046889,GO:0048255,GO:0048511,GO:0048661,GO:0048714,GO:0050731,GO:0050882,GO:0051219,GO:0051496,GO:0051549,GO:0051647,GO:0051897,GO:0055013,GO:0060048,GO:0060135,GO:0060252,GO:0060999,GO:0061051,GO:0070885,GO:0071230,GO:0071233,GO:0071456,GO:0090335,GO:0090559,GO:0098978,GO:0099524,GO:0099547,GO:0106310,GO:0106311,GO:1900034,GO:1901216,GO:1901838,GO:1903691,GO:1904000,GO:1904056,GO:1904058,GO:1904059,GO:1904193,GO:1904197,GO:1904206,GO:1904213,GO:1904690,GO:1990253" "Golgi membrane|RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 3 promoter sequence-specific DNA binding|TFIIIC-class transcription factor complex binding|regulation of cell growth|negative regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|T-helper 1 cell lineage commitment|heart morphogenesis|heart valve morphogenesis|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrial outer membrane|lysosome|lysosomal membrane|endoplasmic reticulum membrane|cytosol|regulation of glycogen biosynthetic process|energy reserve metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|protein phosphorylation|lysosome organization|cell cycle arrest|germ cell development|brain development|cell aging|response to nutrient|long-term memory|regulation of cell size|visual learning|cellular response to starvation|post-embryonic development|negative regulation of autophagy|positive regulation of lamellipodium assembly|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|positive regulation of myotube differentiation|positive regulation of neuron projection development|endomembrane system|positive regulation of neuron maturation|negative regulation of muscle atrophy|response to activity|membrane|regulation of macroautophagy|negative regulation of macroautophagy|kinase activity|phosphorylation|PML body|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein kinase binding|protein domain specific binding|spinal cord development|protein catabolic process|dendrite|positive regulation of actin filament polymerization|negative regulation of protein ubiquitination|ruffle organization|regulation of myelination|response to nutrient levels|cellular response to nutrient levels|TOR signaling|TORC1 complex|TORC2 complex|regulation of fatty acid beta-oxidation|regulation of response to food|activation of protein kinase B activity|positive regulation of phosphoprotein phosphatase activity|response to insulin|regulation of actin cytoskeleton organization|cellular response to amino acid starvation|social behavior|multicellular organism growth|TORC1 signaling|wound healing|response to cocaine|regulation of circadian rhythm|identical protein binding|ribosome binding|neuronal cell body|regulation of GTPase activity|response to amino acid|anoikis|response to morphine|regulation of carbohydrate utilization|translation regulator activity|phagocytic vesicle|positive regulation of nitric oxide biosynthetic process|regulation of osteoclast differentiation|positive regulation of translation|negative regulation of cell size|positive regulation of transcription by RNA polymerase III|protein autophosphorylation|positive regulation of lipid biosynthetic process|mRNA stabilization|rhythmic process|positive regulation of smooth muscle cell proliferation|positive regulation of oligodendrocyte differentiation|positive regulation of peptidyl-tyrosine phosphorylation|voluntary musculoskeletal movement|phosphoprotein binding|positive regulation of stress fiber assembly|positive regulation of keratinocyte migration|nucleus localization|positive regulation of protein kinase B signaling|cardiac muscle cell development|cardiac muscle contraction|maternal process involved in female pregnancy|positive regulation of glial cell proliferation|positive regulation of dendritic spine development|positive regulation of cell growth involved in cardiac muscle cell development|negative regulation of calcineurin-NFAT signaling cascade|cellular response to amino acid stimulus|cellular response to leucine|cellular response to hypoxia|regulation of brown fat cell differentiation|regulation of membrane permeability|glutamatergic synapse|postsynaptic cytosol|regulation of translation at synapse, modulating synaptic transmission|protein serine kinase activity|protein threonine kinase activity|regulation of cellular response to heat|positive regulation of neuron death|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|positive regulation of wound healing, spreading of epidermal cells|positive regulation of eating behavior|positive regulation of cholangiocyte proliferation|positive regulation of sensory perception of pain|regulation of locomotor rhythm|negative regulation of cholangiocyte apoptotic process|positive regulation of granulosa cell proliferation|positive regulation of skeletal muscle hypertrophy|negative regulation of iodide transmembrane transport|positive regulation of cytoplasmic translational initiation|cellular response to leucine starvation" "hsa01521,hsa01522,hsa04012,hsa04066,hsa04072,hsa04136,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04218,hsa04371,hsa04630,hsa04659,hsa04714,hsa04910,hsa04919,hsa04920,hsa04930,hsa04931,hsa04935,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131,hsa05163,hsa05165,hsa05167,hsa05168,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05212,hsa05214,hsa05215,hsa05221,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|Phospholipase D signaling pathway|Autophagy - other|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Apelin signaling pathway|JAK-STAT signaling pathway|Th17 cell differentiation|Thermogenesis|Insulin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Growth hormone synthesis, secretion and action|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Glioma|Prostate cancer|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" MTPAP 478.186284 494.2835566 462.0890114 0.934866243 -0.097168131 0.818276771 1 4.502467341 4.390520194 55149 mitochondrial poly(A) polymerase "GO:0000287,GO:0002134,GO:0003723,GO:0004652,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0006378,GO:0006397,GO:0016779,GO:0030145,GO:0042802,GO:0042803,GO:0043231,GO:0071044" magnesium ion binding|UTP binding|RNA binding|polynucleotide adenylyltransferase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|mRNA polyadenylation|mRNA processing|nucleotidyltransferase activity|manganese ion binding|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|histone mRNA catabolic process MTR 2052.216712 2014.687597 2089.745827 1.037255518 0.052771332 0.871036303 1 8.847378775 9.572300071 4548 5-methyltetrahydrofolate-homocysteine methyltransferase "GO:0000096,GO:0005515,GO:0005829,GO:0007399,GO:0008270,GO:0008705,GO:0009086,GO:0009235,GO:0031103,GO:0031419,GO:0032259,GO:0042558,GO:0048678,GO:0071732" sulfur amino acid metabolic process|protein binding|cytosol|nervous system development|zinc ion binding|methionine synthase activity|methionine biosynthetic process|cobalamin metabolic process|axon regeneration|cobalamin binding|methylation|pteridine-containing compound metabolic process|response to axon injury|cellular response to nitric oxide "hsa00270,hsa00450,hsa00670" Cysteine and methionine metabolism|Selenocompound metabolism|One carbon pool by folate MTRES1 84.70972924 99.4656849 69.95377357 0.70329555 -0.507797006 0.482542619 1 3.138682895 2.302508488 51250 mitochondrial transcription rescue factor 1 "GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:1903108" RNA binding|protein binding|mitochondrion|mitochondrial matrix|regulation of mitochondrial transcription MTREX 1767.910029 1808.651536 1727.168522 0.954948197 -0.066505622 0.839570249 1 23.12593278 23.03535988 23517 Mtr4 exosome RNA helicase "GO:0000176,GO:0000178,GO:0000398,GO:0000460,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0006401,GO:0016076,GO:0016607,GO:0031499,GO:0071013" "nuclear exosome (RNase complex)|exosome (RNase complex)|mRNA splicing, via spliceosome|maturation of 5.8S rRNA|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|rRNA processing|RNA catabolic process|snRNA catabolic process|nuclear speck|TRAMP complex|catalytic step 2 spliceosome" hsa03018 RNA degradation MTRF1 139.0895456 146.1536594 132.0254318 0.903333056 -0.146670092 0.818993517 1 1.152447027 1.085887426 9617 mitochondrial translation release factor 1 "GO:0003747,GO:0005739,GO:0006449,GO:0070126" translation release factor activity|mitochondrion|regulation of translational termination|mitochondrial translational termination MTRF1L 411.5973044 421.2067269 401.987882 0.954371942 -0.067376466 0.880852165 1 5.391113164 5.36675835 54516 mitochondrial translation release factor 1 like "GO:0003747,GO:0005739,GO:0005759,GO:0070126" translation release factor activity|mitochondrion|mitochondrial matrix|mitochondrial translational termination MTRFR 569.0384512 508.4929402 629.5839622 1.238137076 0.308171047 0.437136653 1 9.071283397 11.71529944 91574 mitochondrial translation release factor in rescue MTRNR2L2 8.463822196 6.08973581 10.83790858 1.779700946 0.831634837 0.617753532 1 0.305672582 0.567439347 100462981 MT-RNR2 like 2 "GO:0005576,GO:0005737,GO:0048019,GO:1900118,GO:2000272" extracellular region|cytoplasm|receptor antagonist activity|negative regulation of execution phase of apoptosis|negative regulation of signaling receptor activity MTRNR2L8 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.198777801 0.161019841 100463486 MT-RNR2 like 8 "GO:0005576,GO:0005737,GO:0048019,GO:1900118,GO:2000272" extracellular region|cytoplasm|receptor antagonist activity|negative regulation of execution phase of apoptosis|negative regulation of signaling receptor activity MTRR 924.1530361 1042.35978 805.9462927 0.773193967 -0.371097715 0.299223057 1 13.77657766 11.11081026 4552 5-methyltetrahydrofolate-homocysteine methyltransferase reductase "GO:0000096,GO:0003958,GO:0005515,GO:0005654,GO:0005829,GO:0006306,GO:0006555,GO:0009086,GO:0009235,GO:0010181,GO:0016491,GO:0016709,GO:0016723,GO:0030586,GO:0032259,GO:0033353,GO:0043418,GO:0045111,GO:0046655,GO:0050444,GO:0050660,GO:0050661,GO:0050667,GO:0055114,GO:0070402,GO:0071949,GO:1904042" "sulfur amino acid metabolic process|NADPH-hemoprotein reductase activity|protein binding|nucleoplasm|cytosol|DNA methylation|methionine metabolic process|methionine biosynthetic process|cobalamin metabolic process|FMN binding|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor|[methionine synthase] reductase activity|methylation|S-adenosylmethionine cycle|homocysteine catabolic process|intermediate filament cytoskeleton|folic acid metabolic process|aquacobalamin reductase (NADPH) activity|flavin adenine dinucleotide binding|NADP binding|homocysteine metabolic process|oxidation-reduction process|NADPH binding|FAD binding|negative regulation of cystathionine beta-synthase activity" MTSS1 869.1360891 1120.511389 617.7607892 0.551320402 -0.859037105 0.017978286 0.579832117 8.599780108 4.945467365 9788 MTSS I-BAR domain containing 1 "GO:0001726,GO:0003785,GO:0005102,GO:0005515,GO:0005737,GO:0007009,GO:0007155,GO:0007169,GO:0015629,GO:0030035,GO:0030036,GO:0030139,GO:0042802,GO:0050680,GO:0061333,GO:0071498,GO:0072102,GO:0072160,GO:2001013" ruffle|actin monomer binding|signaling receptor binding|protein binding|cytoplasm|plasma membrane organization|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|actin cytoskeleton|microspike assembly|actin cytoskeleton organization|endocytic vesicle|identical protein binding|negative regulation of epithelial cell proliferation|renal tubule morphogenesis|cellular response to fluid shear stress|glomerulus morphogenesis|nephron tubule epithelial cell differentiation|epithelial cell proliferation involved in renal tubule morphogenesis MTSS2 816.089917 828.2040702 803.9757639 0.970745971 -0.042834281 0.910114705 1 7.582359802 7.677607662 92154 MTSS I-BAR domain containing 2 "GO:0003785,GO:0005096,GO:0005515,GO:0005546,GO:0007009,GO:0030027,GO:0030864,GO:0031267,GO:0032587,GO:0036120,GO:0090630,GO:0097178,GO:0097581" "actin monomer binding|GTPase activator activity|protein binding|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane organization|lamellipodium|cortical actin cytoskeleton|small GTPase binding|ruffle membrane|cellular response to platelet-derived growth factor stimulus|activation of GTPase activity|ruffle assembly|lamellipodium organization" MTURN 343.2538017 261.8586398 424.6489635 1.621672532 0.697482522 0.124629934 1 3.032750132 5.129980576 222166 "maturin, neural progenitor differentiation regulator homolog" "GO:0005515,GO:0005737,GO:0007275,GO:0032088,GO:0045654,GO:0046330,GO:0070374" protein binding|cytoplasm|multicellular organism development|negative regulation of NF-kappaB transcription factor activity|positive regulation of megakaryocyte differentiation|positive regulation of JNK cascade|positive regulation of ERK1 and ERK2 cascade MTUS1 148.9246224 178.6322504 119.2169944 0.667387855 -0.583402663 0.326963742 1 0.750049188 0.522136404 57509 microtubule associated scaffold protein 1 "GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005794,GO:0005815,GO:0005819,GO:0005874,GO:0005886,GO:0008017,GO:0010758,GO:0015630" extracellular space|nucleus|nucleolus|cytoplasm|mitochondrion|Golgi apparatus|microtubule organizing center|spindle|microtubule|plasma membrane|microtubule binding|regulation of macrophage chemotaxis|microtubule cytoskeleton MTX1 513.789415 503.4181603 524.1606696 1.041203339 0.058251844 0.89045902 1 15.43362825 16.76175611 4580 metaxin 1 "GO:0001401,GO:0003674,GO:0005515,GO:0005737,GO:0007005,GO:0007007,GO:0007595,GO:0015031,GO:0016021,GO:0140275" SAM complex|molecular_function|protein binding|cytoplasm|mitochondrion organization|inner mitochondrial membrane organization|lactation|protein transport|integral component of membrane|MIB complex MTX2 472.8618475 433.3861985 512.3374966 1.182173079 0.241441272 0.562100452 1 12.99554888 16.02476325 10651 metaxin 2 "GO:0001401,GO:0005515,GO:0005730,GO:0005737,GO:0005739,GO:0005741,GO:0006839,GO:0007005,GO:0007007,GO:0015031,GO:0140275" SAM complex|protein binding|nucleolus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial transport|mitochondrion organization|inner mitochondrial membrane organization|protein transport|MIB complex MTX3 777.6848938 762.2319322 793.1378553 1.040546613 0.057341594 0.879905133 1 4.869369119 5.285062977 345778 metaxin 3 "GO:0001401,GO:0003674,GO:0005737,GO:0007005,GO:0007007,GO:0015031,GO:0140275" SAM complex|molecular_function|cytoplasm|mitochondrion organization|inner mitochondrial membrane organization|protein transport|MIB complex MUC1 70.70818654 85.25630134 56.16007174 0.65872048 -0.60226169 0.431604648 1 1.060916682 0.728951064 4582 "mucin 1, cell surface associated" "GO:0000785,GO:0000978,GO:0002039,GO:0002223,GO:0003712,GO:0005515,GO:0005615,GO:0005634,GO:0005796,GO:0005886,GO:0005887,GO:0006977,GO:0006978,GO:0010944,GO:0016266,GO:0016324,GO:0019221,GO:0031982,GO:0033629,GO:0036003,GO:0043618,GO:0070062,GO:0090240,GO:1902166" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|p53 binding|stimulatory C-type lectin receptor signaling pathway|transcription coregulator activity|protein binding|extracellular space|nucleus|Golgi lumen|plasma membrane|integral component of plasma membrane|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of transcription by competitive promoter binding|O-glycan processing|apical plasma membrane|cytokine-mediated signaling pathway|vesicle|negative regulation of cell adhesion mediated by integrin|positive regulation of transcription from RNA polymerase II promoter in response to stress|regulation of transcription from RNA polymerase II promoter in response to stress|extracellular exosome|positive regulation of histone H4 acetylation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" MUC12 8.015727316 9.134603715 6.896850916 0.755024644 -0.405404361 0.864587159 1 0.028268083 0.022262474 10071 "mucin 12, cell surface associated" "GO:0001558,GO:0002223,GO:0003674,GO:0005796,GO:0005886,GO:0005887,GO:0016266" regulation of cell growth|stimulatory C-type lectin receptor signaling pathway|molecular_function|Golgi lumen|plasma membrane|integral component of plasma membrane|O-glycan processing MUC2 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.01625678 0.004115249 4583 "mucin 2, oligomeric mucus/gel-forming" "GO:0002223,GO:0005515,GO:0005615,GO:0005796,GO:0005886,GO:0016266,GO:0030277,GO:0031012,GO:0062023,GO:0070702,GO:0070703" stimulatory C-type lectin receptor signaling pathway|protein binding|extracellular space|Golgi lumen|plasma membrane|O-glycan processing|maintenance of gastrointestinal epithelium|extracellular matrix|collagen-containing extracellular matrix|inner mucus layer|outer mucus layer "hsa05146,hsa05226" Amoebiasis|Gastric cancer MUC20 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.061857929 0.020878325 200958 "mucin 20, cell surface associated" "GO:0000187,GO:0002223,GO:0005576,GO:0005796,GO:0005886,GO:0009925,GO:0016266,GO:0016324,GO:0031528,GO:0042802,GO:0048012" activation of MAPK activity|stimulatory C-type lectin receptor signaling pathway|extracellular region|Golgi lumen|plasma membrane|basal plasma membrane|O-glycan processing|apical plasma membrane|microvillus membrane|identical protein binding|hepatocyte growth factor receptor signaling pathway MUC3A 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.022850257 0 4584 "mucin 3A, cell surface associated" "GO:0002223,GO:0005201,GO:0005576,GO:0005796,GO:0005886,GO:0016021,GO:0016266,GO:0030197" "stimulatory C-type lectin receptor signaling pathway|extracellular matrix structural constituent|extracellular region|Golgi lumen|plasma membrane|integral component of membrane|O-glycan processing|extracellular matrix constituent, lubricant activity" MUCL3 6.552676467 10.14955968 2.95579325 0.291223791 -1.779799875 0.306941875 1 0.09675125 0.029389985 135656 mucin like 3 "GO:0003674,GO:0005575,GO:0005737,GO:0005886,GO:0008150,GO:0016021" molecular_function|cellular_component|cytoplasm|plasma membrane|biological_process|integral component of membrane MUL1 608.447544 710.4691779 506.4259101 0.712804898 -0.488420844 0.210233078 1 11.45582855 8.517518989 79594 mitochondrial E3 ubiquitin protein ligase 1 "GO:0000209,GO:0000266,GO:0002039,GO:0004842,GO:0005515,GO:0005739,GO:0005777,GO:0006915,GO:0006919,GO:0007257,GO:0010637,GO:0010821,GO:0016020,GO:0016567,GO:0016925,GO:0019789,GO:0030308,GO:0030424,GO:0031307,GO:0031625,GO:0031648,GO:0033235,GO:0042802,GO:0043025,GO:0043123,GO:0045824,GO:0046872,GO:0050689,GO:0050821,GO:0051646,GO:0051881,GO:0051898,GO:0060339,GO:0061630,GO:0071360,GO:0071650,GO:0090141,GO:1901028,GO:1903861,GO:1904925" protein polyubiquitination|mitochondrial fission|p53 binding|ubiquitin-protein transferase activity|protein binding|mitochondrion|peroxisome|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|activation of JUN kinase activity|negative regulation of mitochondrial fusion|regulation of mitochondrion organization|membrane|protein ubiquitination|protein sumoylation|SUMO transferase activity|negative regulation of cell growth|axon|integral component of mitochondrial outer membrane|ubiquitin protein ligase binding|protein destabilization|positive regulation of protein sumoylation|identical protein binding|neuronal cell body|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of innate immune response|metal ion binding|negative regulation of defense response to virus by host|protein stabilization|mitochondrion localization|regulation of mitochondrial membrane potential|negative regulation of protein kinase B signaling|negative regulation of type I interferon-mediated signaling pathway|ubiquitin protein ligase activity|cellular response to exogenous dsRNA|negative regulation of chemokine (C-C motif) ligand 5 production|positive regulation of mitochondrial fission|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of dendrite extension|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization MUS81 699.9556469 735.8430771 664.0682168 0.902459013 -0.148066685 0.697258489 1 15.17420845 14.28398752 80198 MUS81 structure-specific endonuclease subunit "GO:0000712,GO:0000727,GO:0000737,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006281,GO:0031573,GO:0033687,GO:0036297,GO:0046872,GO:0048257,GO:0048476,GO:0072429" "resolution of meiotic recombination intermediates|double-strand break repair via break-induced replication|DNA catabolic process, endonucleolytic|DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|DNA repair|intra-S DNA damage checkpoint|osteoblast proliferation|interstrand cross-link repair|metal ion binding|3'-flap endonuclease activity|Holliday junction resolvase complex|response to intra-S DNA damage checkpoint signaling" "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway MUSTN1 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.098286691 0.298564037 389125 "musculoskeletal, embryonic nuclear protein 1" "GO:0002062,GO:0005634,GO:0035988,GO:0042246" chondrocyte differentiation|nucleus|chondrocyte proliferation|tissue regeneration MUTYH 474.6663512 455.7152298 493.6174727 1.083170894 0.115260877 0.784608299 1 8.618509605 9.737446422 4595 mutY DNA glycosylase "GO:0000701,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006281,GO:0006284,GO:0006298,GO:0019104,GO:0032357,GO:0032405,GO:0032406,GO:0032407,GO:0032408,GO:0034039,GO:0035485,GO:0045007,GO:0046872,GO:0051539" "purine-specific mismatch base pair DNA N-glycosylase activity|protein binding|nucleus|nucleoplasm|mitochondrion|DNA repair|base-excision repair|mismatch repair|DNA N-glycosylase activity|oxidized purine DNA binding|MutLalpha complex binding|MutLbeta complex binding|MutSalpha complex binding|MutSbeta complex binding|8-oxo-7,8-dihydroguanine DNA N-glycosylase activity|adenine/guanine mispair binding|depurination|metal ion binding|4 iron, 4 sulfur cluster binding" hsa03410 Base excision repair MVB12A 489.1996203 539.9565752 438.4426654 0.81199616 -0.300455191 0.46572392 1 18.21911771 15.43111282 93343 multivesicular body subunit 12A "GO:0000813,GO:0005515,GO:0005654,GO:0005794,GO:0005813,GO:0005829,GO:0008289,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0017124,GO:0019058,GO:0019075,GO:0031902,GO:0031982,GO:0032510,GO:0032801,GO:0036258,GO:0039702,GO:0042058,GO:0043130,GO:0043162,GO:0043657,GO:0046755,GO:0070062,GO:0075733" ESCRT I complex|protein binding|nucleoplasm|Golgi apparatus|centrosome|cytosol|lipid binding|endosome membrane|protein transport|endosomal transport|macroautophagy|SH3 domain binding|viral life cycle|virus maturation|late endosome membrane|vesicle|endosome to lysosome transport via multivesicular body sorting pathway|receptor catabolic process|multivesicular body assembly|viral budding via host ESCRT complex|regulation of epidermal growth factor receptor signaling pathway|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|host cell|viral budding|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis MVB12B 384.9142553 314.6363502 455.1921604 1.44672464 0.532790355 0.224625487 1 1.989912733 3.002865214 89853 multivesicular body subunit 12B "GO:0000813,GO:0005515,GO:0005634,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0008289,GO:0010008,GO:0015031,GO:0016197,GO:0019058,GO:0019075,GO:0031902,GO:0031982,GO:0042058,GO:0043130,GO:0043162,GO:0043657,GO:0046755,GO:0070062,GO:0075733" ESCRT I complex|protein binding|nucleus|early endosome|late endosome|cytosol|plasma membrane|lipid binding|endosome membrane|protein transport|endosomal transport|viral life cycle|virus maturation|late endosome membrane|vesicle|regulation of epidermal growth factor receptor signaling pathway|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|host cell|viral budding|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis MVD 590.3322375 617.0932288 563.5712463 0.913267591 -0.130890458 0.741646729 1 14.92530805 14.21795971 4597 mevalonate diphosphate decarboxylase "GO:0004163,GO:0005524,GO:0005777,GO:0005829,GO:0006489,GO:0006695,GO:0008284,GO:0008299,GO:0019287,GO:0030544,GO:0042803,GO:0045540" "diphosphomevalonate decarboxylase activity|ATP binding|peroxisome|cytosol|dolichyl diphosphate biosynthetic process|cholesterol biosynthetic process|positive regulation of cell population proliferation|isoprenoid biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway|Hsp70 protein binding|protein homodimerization activity|regulation of cholesterol biosynthetic process" hsa00900 Terpenoid backbone biosynthesis MVK 237.3433201 194.8715459 279.8150943 1.435895081 0.521950338 0.306682086 1 3.615222101 5.41469029 4598 mevalonate kinase "GO:0000287,GO:0004496,GO:0005515,GO:0005524,GO:0005777,GO:0005829,GO:0006695,GO:0008299,GO:0016310,GO:0019287,GO:0042802,GO:0043231,GO:0045540,GO:0050728" "magnesium ion binding|mevalonate kinase activity|protein binding|ATP binding|peroxisome|cytosol|cholesterol biosynthetic process|isoprenoid biosynthetic process|phosphorylation|isopentenyl diphosphate biosynthetic process, mevalonate pathway|identical protein binding|intracellular membrane-bounded organelle|regulation of cholesterol biosynthetic process|negative regulation of inflammatory response" "hsa00900,hsa04146" Terpenoid backbone biosynthesis|Peroxisome MVP 2856.88553 3038.778169 2674.992891 0.880285675 -0.183956305 0.563594251 1 52.61654499 48.31276477 9961 major vault protein "GO:0005515,GO:0005576,GO:0005634,GO:0005643,GO:0005737,GO:0005829,GO:0005856,GO:0015031,GO:0016020,GO:0019901,GO:0019903,GO:0031953,GO:0034774,GO:0038127,GO:0042059,GO:0042802,GO:0043312,GO:0048471,GO:0051028,GO:0061099,GO:0070062,GO:1904813" protein binding|extracellular region|nucleus|nuclear pore|cytoplasm|cytosol|cytoskeleton|protein transport|membrane|protein kinase binding|protein phosphatase binding|negative regulation of protein autophosphorylation|secretory granule lumen|ERBB signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|identical protein binding|neutrophil degranulation|perinuclear region of cytoplasm|mRNA transport|negative regulation of protein tyrosine kinase activity|extracellular exosome|ficolin-1-rich granule lumen MX1 313.536525 385.683268 241.3897821 0.625875692 -0.676051951 0.147544243 1 3.345349703 2.18396431 4599 MX dynamin like GTPase 1 "GO:0000266,GO:0003374,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0006915,GO:0006952,GO:0007165,GO:0008017,GO:0009615,GO:0014069,GO:0015630,GO:0016020,GO:0016185,GO:0030424,GO:0031410,GO:0031623,GO:0031965,GO:0031966,GO:0034340,GO:0042802,GO:0044327,GO:0045071,GO:0045087,GO:0048285,GO:0048471,GO:0050803,GO:0051607,GO:0060337,GO:0061025,GO:0098793,GO:0098844,GO:0098884" mitochondrial fission|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|apoptotic process|defense response|signal transduction|microtubule binding|response to virus|postsynaptic density|microtubule cytoskeleton|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|axon|cytoplasmic vesicle|receptor internalization|nuclear membrane|mitochondrial membrane|response to type I interferon|identical protein binding|dendritic spine head|negative regulation of viral genome replication|innate immune response|organelle fission|perinuclear region of cytoplasm|regulation of synapse structure or activity|defense response to virus|type I interferon signaling pathway|membrane fusion|presynapse|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization "hsa05160,hsa05162,hsa05164,hsa05165,hsa05171" Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Coronavirus disease - COVID-19 MX2 47.37632344 73.07682972 21.67581716 0.296616824 -1.753327664 0.046268064 0.975235287 0.984592611 0.304626922 4600 MX dynamin like GTPase 2 "GO:0000266,GO:0003374,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005643,GO:0005737,GO:0005829,GO:0005886,GO:0006952,GO:0008017,GO:0009615,GO:0014069,GO:0015630,GO:0016020,GO:0016185,GO:0030424,GO:0031410,GO:0031623,GO:0031966,GO:0035455,GO:0044327,GO:0046822,GO:0048285,GO:0050803,GO:0051028,GO:0051607,GO:0051726,GO:0060337,GO:0061025,GO:0098793,GO:0098844,GO:0098884" mitochondrial fission|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|protein binding|GTP binding|nucleus|nuclear pore|cytoplasm|cytosol|plasma membrane|defense response|microtubule binding|response to virus|postsynaptic density|microtubule cytoskeleton|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|axon|cytoplasmic vesicle|receptor internalization|mitochondrial membrane|response to interferon-alpha|dendritic spine head|regulation of nucleocytoplasmic transport|organelle fission|regulation of synapse structure or activity|mRNA transport|defense response to virus|regulation of cell cycle|type I interferon signaling pathway|membrane fusion|presynapse|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization "hsa05160,hsa05162,hsa05164,hsa05165,hsa05171" Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Coronavirus disease - COVID-19 MXD1 100.3106564 88.30116925 112.3201435 1.272011961 0.347112237 0.615141653 1 0.805936694 1.069320898 4084 MAX dimerization protein 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0006357,GO:0046983" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|protein dimerization activity" MXD3 355.8840898 249.6791682 462.0890114 1.850731139 0.888095326 0.048606007 1 4.575024984 8.831871302 83463 MAX dimerization protein 3 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046983" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|protein dimerization activity" MXD4 753.2099059 671.9008511 834.5189608 1.242026944 0.312696471 0.40096065 1 8.790857087 11.38880526 10608 MAX dimerization protein 4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046983" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|protein dimerization activity" MXI1 408.3243067 466.8797455 349.7688679 0.749162651 -0.416649118 0.334346981 1 6.152956558 4.808126624 4601 "MAX interactor 1, dimerization protein" "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0046983,GO:0090575" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|protein dimerization activity|RNA polymerase II transcription regulator complex" bHLH MXRA7 1252.186458 1408.758884 1095.614031 0.777715792 -0.362685061 0.285998675 1 9.384278269 7.612682631 439921 matrix remodeling associated 7 "GO:0005783,GO:0016021,GO:0062023" endoplasmic reticulum|integral component of membrane|collagen-containing extracellular matrix MXRA8 5.030242514 7.104691779 2.95579325 0.416033987 -1.265226703 0.543955984 1 0.125026954 0.054256078 54587 matrix remodeling associated 8 "GO:0003674,GO:0005515,GO:0005634,GO:0005788,GO:0005923,GO:0007155,GO:0009986,GO:0016021,GO:0016032,GO:0043687,GO:0044267,GO:0060170,GO:0060857,GO:0070062" molecular_function|protein binding|nucleus|endoplasmic reticulum lumen|bicellular tight junction|cell adhesion|cell surface|integral component of membrane|viral process|post-translational protein modification|cellular protein metabolic process|ciliary membrane|establishment of glial blood-brain barrier|extracellular exosome MYADM 3391.204916 3497.538267 3284.871565 0.939195318 -0.090502878 0.776591824 1 46.37119755 45.42763843 91663 myeloid associated differentiation marker "GO:0001726,GO:0001933,GO:0003674,GO:0005515,GO:0005886,GO:0005911,GO:0010629,GO:0010810,GO:0016021,GO:0030335,GO:0030837,GO:0030864,GO:0031579,GO:0034115,GO:0045121,GO:0045217,GO:0061028,GO:0072659,GO:0090038,GO:1900026" ruffle|negative regulation of protein phosphorylation|molecular_function|protein binding|plasma membrane|cell-cell junction|negative regulation of gene expression|regulation of cell-substrate adhesion|integral component of membrane|positive regulation of cell migration|negative regulation of actin filament polymerization|cortical actin cytoskeleton|membrane raft organization|negative regulation of heterotypic cell-cell adhesion|membrane raft|cell-cell junction maintenance|establishment of endothelial barrier|protein localization to plasma membrane|negative regulation of protein kinase C signaling|positive regulation of substrate adhesion-dependent cell spreading MYB 11.52353588 13.19442759 9.852644165 0.74672767 -0.421345905 0.803618457 1 0.181837064 0.141631738 4602 "MYB proto-oncogene, transcription factor" "GO:0000122,GO:0000278,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006338,GO:0006355,GO:0016363,GO:0032967,GO:0043525,GO:0045624,GO:0045892,GO:0045893,GO:0045944,GO:0048661,GO:0051571,GO:0051574,GO:0060252,GO:0070301,GO:0071300,GO:0071636,GO:1902036,GO:1904899,GO:2000491,GO:2000845" "negative regulation of transcription by RNA polymerase II|mitotic cell cycle|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|protein binding|nucleus|nucleoplasm|cytosol|chromatin remodeling|regulation of transcription, DNA-templated|nuclear matrix|positive regulation of collagen biosynthetic process|positive regulation of neuron apoptotic process|positive regulation of T-helper cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle cell proliferation|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of glial cell proliferation|cellular response to hydrogen peroxide|cellular response to retinoic acid|positive regulation of transforming growth factor beta production|regulation of hematopoietic stem cell differentiation|positive regulation of hepatic stellate cell proliferation|positive regulation of hepatic stellate cell activation|positive regulation of testosterone secretion" hsa04151 PI3K-Akt signaling pathway MYB MYBBP1A 1718.086628 1905.072353 1531.100903 0.803696984 -0.315276428 0.334340548 1 21.27098632 17.83182923 10514 MYB binding protein 1a "GO:0001649,GO:0003714,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006355,GO:0008134,GO:0016020,GO:0022904,GO:0032922,GO:0042149,GO:0042254,GO:0042564,GO:0043231,GO:0043565,GO:0045815,GO:0045892,GO:0070888,GO:0071158,GO:0072332,GO:2000210" "osteoblast differentiation|transcription corepressor activity|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|regulation of transcription, DNA-templated|transcription factor binding|membrane|respiratory electron transport chain|circadian regulation of gene expression|cellular response to glucose starvation|ribosome biogenesis|NLS-dependent protein nuclear import complex|intracellular membrane-bounded organelle|sequence-specific DNA binding|positive regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|E-box binding|positive regulation of cell cycle arrest|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of anoikis" MYBL1 451.4520166 283.1727152 619.731318 2.188527654 1.129960614 0.007588763 0.357146179 2.504225432 5.716647193 4603 MYB proto-oncogene like 1 "GO:0000278,GO:0000978,GO:0000981,GO:0001228,GO:0005634,GO:0005654,GO:0006355,GO:0007141,GO:0007283,GO:0010529,GO:0030154,GO:0045893,GO:0045944,GO:1990511" "mitotic cell cycle|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription, DNA-templated|male meiosis I|spermatogenesis|negative regulation of transposition|cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|piRNA biosynthetic process" MYB MYBL2 3911.59748 3206.245904 4616.949056 1.439985951 0.526054736 0.099260479 1 60.86395955 91.41856227 4605 MYB proto-oncogene like 2 "GO:0000278,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0031523,GO:0043525,GO:0045944,GO:0051726,GO:0090307,GO:1990830,GO:1990837" "mitotic cell cycle|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|Myb complex|positive regulation of neuron apoptotic process|positive regulation of transcription by RNA polymerase II|regulation of cell cycle|mitotic spindle assembly|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" hsa04218 Cellular senescence MYB MYBPC3 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.048758776 0 4607 myosin binding protein C3 "GO:0001671,GO:0003007,GO:0003779,GO:0005515,GO:0005829,GO:0005863,GO:0006942,GO:0007155,GO:0008307,GO:0014705,GO:0017022,GO:0030017,GO:0030049,GO:0031432,GO:0031672,GO:0032036,GO:0032781,GO:0032971,GO:0042802,GO:0046872,GO:0055010,GO:0060048,GO:0097512" ATPase activator activity|heart morphogenesis|actin binding|protein binding|cytosol|striated muscle myosin thick filament|regulation of striated muscle contraction|cell adhesion|structural constituent of muscle|C zone|myosin binding|sarcomere|muscle filament sliding|titin binding|A band|myosin heavy chain binding|positive regulation of ATPase activity|regulation of muscle filament sliding|identical protein binding|metal ion binding|ventricular cardiac muscle tissue morphogenesis|cardiac muscle contraction|cardiac myofibril "hsa05410,hsa05414" Hypertrophic cardiomyopathy|Dilated cardiomyopathy MYC 1024.126199 1242.306105 805.9462927 0.648750167 -0.624265091 0.075701428 1 13.92616681 9.423777094 4609 "MYC proto-oncogene, bHLH transcription factor" "GO:0000082,GO:0000122,GO:0000165,GO:0000785,GO:0000978,GO:0000981,GO:0001046,GO:0001227,GO:0001228,GO:0001658,GO:0002053,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006112,GO:0006338,GO:0006357,GO:0006879,GO:0006974,GO:0007050,GO:0007219,GO:0008134,GO:0008284,GO:0010332,GO:0010468,GO:0010628,GO:0015671,GO:0016579,GO:0019221,GO:0032204,GO:0032873,GO:0032986,GO:0032991,GO:0033613,GO:0034644,GO:0035690,GO:0042493,GO:0043066,GO:0043280,GO:0044346,GO:0044877,GO:0045656,GO:0045893,GO:0045944,GO:0046983,GO:0048146,GO:0048147,GO:0050679,GO:0051276,GO:0051782,GO:0051973,GO:0070371,GO:0070491,GO:0070848,GO:0070888,GO:0071456,GO:0090096,GO:1904672,GO:1904837,GO:1905643,GO:2000573,GO:2001022" "G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|MAPK cascade|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|core promoter sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal cell proliferation|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|energy reserve metabolic process|chromatin remodeling|regulation of transcription by RNA polymerase II|cellular iron ion homeostasis|cellular response to DNA damage stimulus|cell cycle arrest|Notch signaling pathway|transcription factor binding|positive regulation of cell population proliferation|response to gamma radiation|regulation of gene expression|positive regulation of gene expression|oxygen transport|protein deubiquitination|cytokine-mediated signaling pathway|regulation of telomere maintenance|negative regulation of stress-activated MAPK cascade|protein-DNA complex disassembly|protein-containing complex|activating transcription factor binding|cellular response to UV|cellular response to drug|response to drug|negative regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|fibroblast apoptotic process|protein-containing complex binding|negative regulation of monocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|positive regulation of fibroblast proliferation|negative regulation of fibroblast proliferation|positive regulation of epithelial cell proliferation|chromosome organization|negative regulation of cell division|positive regulation of telomerase activity|ERK1 and ERK2 cascade|repressing transcription factor binding|response to growth factor|E-box binding|cellular response to hypoxia|positive regulation of metanephric cap mesenchymal cell proliferation|regulation of somatic stem cell population maintenance|beta-catenin-TCF complex assembly|positive regulation of DNA methylation|positive regulation of DNA biosynthetic process|positive regulation of response to DNA damage stimulus" "hsa04010,hsa04012,hsa04110,hsa04151,hsa04218,hsa04310,hsa04350,hsa04390,hsa04550,hsa04630,hsa04919,hsa05132,hsa05160,hsa05161,hsa05163,hsa05166,hsa05167,hsa05169,hsa05200,hsa05202,hsa05205,hsa05206,hsa05210,hsa05213,hsa05216,hsa05219,hsa05220,hsa05221,hsa05222,hsa05224,hsa05225,hsa05226,hsa05230" MAPK signaling pathway|ErbB signaling pathway|Cell cycle|PI3K-Akt signaling pathway|Cellular senescence|Wnt signaling pathway|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|Thyroid hormone signaling pathway|Salmonella infection|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Endometrial cancer|Thyroid cancer|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer bHLH MYCBP 664.9126961 630.2876564 699.5377357 1.109870594 0.150391475 0.696097765 1 12.60736425 14.59528485 26292 MYC binding protein "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006355,GO:0007283,GO:0045893" "transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|regulation of transcription, DNA-templated|spermatogenesis|positive regulation of transcription, DNA-templated" MYCBP2 2118.375164 2058.330704 2178.419625 1.05834287 0.081807092 0.799957874 1 6.553953778 7.235119229 23077 MYC binding protein 2 "GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0015630,GO:0016020,GO:0016567,GO:0021785,GO:0021952,GO:0030424,GO:0031267,GO:0031398,GO:0032880,GO:0032922,GO:0042177,GO:0042802,GO:0043231,GO:0050790,GO:0050905,GO:0051493,GO:0061630,GO:1902667" guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|microtubule cytoskeleton|membrane|protein ubiquitination|branchiomotor neuron axon guidance|central nervous system projection neuron axonogenesis|axon|small GTPase binding|positive regulation of protein ubiquitination|regulation of protein localization|circadian regulation of gene expression|negative regulation of protein catabolic process|identical protein binding|intracellular membrane-bounded organelle|regulation of catalytic activity|neuromuscular process|regulation of cytoskeleton organization|ubiquitin protein ligase activity|regulation of axon guidance MYCBPAP 9.538161268 12.17947162 6.896850916 0.566268483 -0.82044186 0.599184136 1 0.13138387 0.077603332 84073 MYCBP associated protein "GO:0005515,GO:0005737,GO:0007268,GO:0007275,GO:0007283,GO:0016020,GO:0030154,GO:0045202" protein binding|cytoplasm|chemical synaptic transmission|multicellular organism development|spermatogenesis|membrane|cell differentiation|synapse MYCL 23.21037529 37.55337083 8.867379749 0.236127398 -2.082362645 0.058482394 1 0.392234636 0.096606924 4610 "MYCL proto-oncogene, bHLH transcription factor" "GO:0000785,GO:0000978,GO:0000981,GO:0003677,GO:0005654,GO:0005694,GO:0006357,GO:0045607,GO:0046983" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleoplasm|chromosome|regulation of transcription by RNA polymerase II|regulation of inner ear auditory receptor cell differentiation|protein dimerization activity" MYCT1 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.026356489 0 80177 MYC target 1 "GO:0005654,GO:0043231,GO:0061484" nucleoplasm|intracellular membrane-bounded organelle|hematopoietic stem cell homeostasis MYD88 1340.871142 1274.784696 1406.957587 1.103682521 0.142325234 0.673456074 1 23.93894983 27.55911004 4615 MYD88 innate immune signal transduction adaptor "GO:0002224,GO:0002238,GO:0002755,GO:0005121,GO:0005123,GO:0005149,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006909,GO:0006915,GO:0006954,GO:0007165,GO:0007166,GO:0007254,GO:0008063,GO:0009615,GO:0009682,GO:0010008,GO:0010628,GO:0014069,GO:0016064,GO:0031663,GO:0032481,GO:0032494,GO:0032722,GO:0032740,GO:0032747,GO:0032755,GO:0032757,GO:0032760,GO:0032991,GO:0034162,GO:0035325,GO:0042742,GO:0042802,GO:0042832,GO:0043066,GO:0043123,GO:0043621,GO:0045087,GO:0046330,GO:0048661,GO:0050671,GO:0050727,GO:0050830,GO:0051092,GO:0060337,GO:0070498,GO:0070555,GO:0070935,GO:0070976,GO:0071222,GO:0071260,GO:0090557,GO:0140052,GO:1900017,GO:1902622,GO:2000338,GO:2000341" toll-like receptor signaling pathway|response to molecule of fungal origin|MyD88-dependent toll-like receptor signaling pathway|Toll binding|death receptor binding|interleukin-1 receptor binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|phagocytosis|apoptotic process|inflammatory response|signal transduction|cell surface receptor signaling pathway|JNK cascade|Toll signaling pathway|response to virus|induced systemic resistance|endosome membrane|positive regulation of gene expression|postsynaptic density|immunoglobulin mediated immune response|lipopolysaccharide-mediated signaling pathway|positive regulation of type I interferon production|response to peptidoglycan|positive regulation of chemokine production|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|protein-containing complex|toll-like receptor 9 signaling pathway|Toll-like receptor binding|defense response to bacterium|identical protein binding|defense response to protozoan|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein self-association|innate immune response|positive regulation of JNK cascade|positive regulation of smooth muscle cell proliferation|positive regulation of lymphocyte proliferation|regulation of inflammatory response|defense response to Gram-positive bacterium|positive regulation of NF-kappaB transcription factor activity|type I interferon signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-1|3'-UTR-mediated mRNA stabilization|TIR domain binding|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|establishment of endothelial intestinal barrier|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of cytokine production involved in inflammatory response|regulation of neutrophil migration|regulation of chemokine (C-X-C motif) ligand 1 production|regulation of chemokine (C-X-C motif) ligand 2 production "hsa04010,hsa04064,hsa04620,hsa04621,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05143,hsa05144,hsa05145,hsa05152,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05170,hsa05171,hsa05235" MAPK signaling pathway|NF-kappa B signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|African trypanosomiasis|Malaria|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|PD-L1 expression and PD-1 checkpoint pathway in cancer MYDGF 1774.383033 1880.713409 1668.052657 0.886925487 -0.173115189 0.595392586 1 67.458569 62.40798913 56005 myeloid derived growth factor "GO:0001525,GO:0001934,GO:0001938,GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0005793,GO:0005794,GO:0006915,GO:0014068,GO:0036498,GO:0043066,GO:0043410,GO:0045766,GO:0045944,GO:0051897" angiogenesis|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|apoptotic process|positive regulation of phosphatidylinositol 3-kinase signaling|IRE1-mediated unfolded protein response|negative regulation of apoptotic process|positive regulation of MAPK cascade|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of protein kinase B signaling MYEOV 82.98885699 150.2134833 15.76423066 0.10494551 -3.252287647 4.82E-05 0.008715627 3.19520496 0.349766745 26579 myeloma overexpressed GO:0005515 protein binding MYG1 934.4889099 974.3577296 894.6200902 0.918163897 -0.12317639 0.731722393 1 41.05472685 39.31871435 60314 MYG1 exonuclease "GO:0003674,GO:0004518,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0035641,GO:0090305" molecular_function|nuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|mitochondrial matrix|locomotory exploration behavior|nucleic acid phosphodiester bond hydrolysis MYH1 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.008534607 0.043209085 4619 myosin heavy chain 1 "GO:0003774,GO:0005515,GO:0005516,GO:0005524,GO:0005859,GO:0006936,GO:0014704,GO:0031672,GO:0032982,GO:0036464,GO:0051015" motor activity|protein binding|calmodulin binding|ATP binding|muscle myosin complex|muscle contraction|intercalated disc|A band|myosin filament|cytoplasmic ribonucleoprotein granule|actin filament binding MYH10 6487.249402 6249.083897 6725.414907 1.076224134 0.105978565 0.745278172 1 37.91256037 42.56001491 4628 myosin heavy chain 10 "GO:0000146,GO:0000281,GO:0001725,GO:0003779,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0005938,GO:0007155,GO:0008360,GO:0016459,GO:0016460,GO:0016887,GO:0030027,GO:0030048,GO:0030496,GO:0030898,GO:0031032,GO:0032154,GO:0035613,GO:0042641,GO:0043531,GO:0048027,GO:0050714,GO:0051015,GO:0070062,GO:0097513,GO:0098885" microfilament motor activity|mitotic cytokinesis|stress fiber|actin binding|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|polysome|cell cortex|cell adhesion|regulation of cell shape|myosin complex|myosin II complex|ATPase activity|lamellipodium|actin filament-based movement|midbody|actin-dependent ATPase activity|actomyosin structure organization|cleavage furrow|RNA stem-loop binding|actomyosin|ADP binding|mRNA 5'-UTR binding|positive regulation of protein secretion|actin filament binding|extracellular exosome|myosin II filament|modification of postsynaptic actin cytoskeleton "hsa04270,hsa04530,hsa04810,hsa05130" Vascular smooth muscle contraction|Tight junction|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection MYH13 1.970528833 0 3.941057666 Inf Inf 0.26888406 1 0 0.03473451 8735 myosin heavy chain 13 "GO:0000146,GO:0005516,GO:0005524,GO:0005859,GO:0006936,GO:0009267,GO:0030016,GO:0032982,GO:0051015,GO:0070062" microfilament motor activity|calmodulin binding|ATP binding|muscle myosin complex|muscle contraction|cellular response to starvation|myofibril|myosin filament|actin filament binding|extracellular exosome MYH15 9.538161268 12.17947162 6.896850916 0.566268483 -0.82044186 0.599184136 1 0.082809407 0.04891229 22989 myosin heavy chain 15 "GO:0002074,GO:0003774,GO:0005516,GO:0005524,GO:0005829,GO:0016459,GO:0030016,GO:0032982,GO:0043231,GO:0051015" extraocular skeletal muscle development|motor activity|calmodulin binding|ATP binding|cytosol|myosin complex|myofibril|myosin filament|intracellular membrane-bounded organelle|actin filament binding MYH3 17.55388858 21.31407534 13.79370183 0.64716398 -0.627796782 0.611011459 1 0.175926128 0.118757381 4621 myosin heavy chain 3 "GO:0000146,GO:0003009,GO:0005516,GO:0005524,GO:0005829,GO:0005859,GO:0006470,GO:0007517,GO:0016887,GO:0017018,GO:0030017,GO:0030048,GO:0030049,GO:0030326,GO:0032982,GO:0045214,GO:0046034,GO:0051015,GO:0060325,GO:0070062" microfilament motor activity|skeletal muscle contraction|calmodulin binding|ATP binding|cytosol|muscle myosin complex|protein dephosphorylation|muscle organ development|ATPase activity|myosin phosphatase activity|sarcomere|actin filament-based movement|muscle filament sliding|embryonic limb morphogenesis|myosin filament|sarcomere organization|ATP metabolic process|actin filament binding|face morphogenesis|extracellular exosome MYH7B 14.09061735 20.29911937 7.882115332 0.388298388 -1.364762376 0.280683921 1 0.131653065 0.053322744 57644 myosin heavy chain 7B "GO:0003774,GO:0005515,GO:0005524,GO:0016020,GO:0016459,GO:0032982,GO:0051015,GO:0097512" motor activity|protein binding|ATP binding|membrane|myosin complex|myosin filament|actin filament binding|cardiac myofibril MYH9 40207.30512 41974.51903 38440.09121 0.915795871 -0.126902035 0.757183 1 285.3122147 272.5429646 4627 myosin heavy chain 9 "GO:0000146,GO:0000212,GO:0001525,GO:0001701,GO:0001725,GO:0001726,GO:0001768,GO:0001772,GO:0001778,GO:0001931,GO:0003723,GO:0003774,GO:0003779,GO:0005178,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0005826,GO:0005829,GO:0005886,GO:0005903,GO:0005912,GO:0005925,GO:0006509,GO:0006911,GO:0007229,GO:0007520,GO:0008180,GO:0008360,GO:0009898,GO:0015031,GO:0015629,GO:0016020,GO:0016460,GO:0016887,GO:0019904,GO:0030048,GO:0030220,GO:0030224,GO:0030898,GO:0031032,GO:0031252,GO:0031532,GO:0031594,GO:0032154,GO:0032418,GO:0032506,GO:0032796,GO:0032991,GO:0042641,GO:0042802,GO:0042803,GO:0043495,GO:0043531,GO:0043534,GO:0045055,GO:0045296,GO:0050900,GO:0051015,GO:0051295,GO:0070062,GO:0070527,GO:0097513,GO:1903919,GO:1903923,GO:1905684" "microfilament motor activity|meiotic spindle organization|angiogenesis|in utero embryonic development|stress fiber|ruffle|establishment of T cell polarity|immunological synapse|plasma membrane repair|uropod|RNA binding|motor activity|actin binding|integrin binding|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|spindle|actomyosin contractile ring|cytosol|plasma membrane|brush border|adherens junction|focal adhesion|membrane protein ectodomain proteolysis|phagocytosis, engulfment|integrin-mediated signaling pathway|myoblast fusion|COP9 signalosome|regulation of cell shape|cytoplasmic side of plasma membrane|protein transport|actin cytoskeleton|membrane|myosin II complex|ATPase activity|protein domain specific binding|actin filament-based movement|platelet formation|monocyte differentiation|actin-dependent ATPase activity|actomyosin structure organization|cell leading edge|actin cytoskeleton reorganization|neuromuscular junction|cleavage furrow|lysosome localization|cytokinetic process|uropod organization|protein-containing complex|actomyosin|identical protein binding|protein homodimerization activity|protein-membrane adaptor activity|ADP binding|blood vessel endothelial cell migration|regulated exocytosis|cadherin binding|leukocyte migration|actin filament binding|establishment of meiotic spindle localization|extracellular exosome|platelet aggregation|myosin II filament|negative regulation of actin filament severing|positive regulation of protein processing in phagocytic vesicle|regulation of plasma membrane repair" "hsa04270,hsa04530,hsa04810,hsa05130" Vascular smooth muscle contraction|Tight junction|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection MYL12A 7982.928299 7868.953623 8096.902975 1.028968191 0.041198384 0.901129818 1 332.6667287 357.0485278 10627 myosin light chain 12A "GO:0005509,GO:0005515,GO:0005829,GO:0006936,GO:0016459,GO:0070062,GO:0070527" calcium ion binding|protein binding|cytosol|muscle contraction|myosin complex|extracellular exosome|platelet aggregation "hsa04360,hsa04510,hsa04530,hsa04611,hsa04670,hsa04810,hsa05131,hsa05132" Axon guidance|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Salmonella infection MYL12B 10623.2484 9270.607815 11975.88898 1.291812708 0.369396917 0.275176428 1 405.4607781 546.3416773 103910 myosin light chain 12B "GO:0005509,GO:0005515,GO:0005829,GO:0006936,GO:0016459,GO:0070062,GO:0099738" calcium ion binding|protein binding|cytosol|muscle contraction|myosin complex|extracellular exosome|cell cortex region "hsa04360,hsa04510,hsa04530,hsa04611,hsa04670,hsa04810,hsa05131,hsa05132" Axon guidance|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Salmonella infection MYL2 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.131299973 0.199423999 4633 myosin light chain 2 "GO:0002026,GO:0003785,GO:0005509,GO:0005515,GO:0005829,GO:0005856,GO:0006942,GO:0007507,GO:0008307,GO:0015629,GO:0016459,GO:0030016,GO:0030017,GO:0030049,GO:0030308,GO:0031672,GO:0032036,GO:0055003,GO:0055010,GO:0060047,GO:0097512,GO:0098735" regulation of the force of heart contraction|actin monomer binding|calcium ion binding|protein binding|cytosol|cytoskeleton|regulation of striated muscle contraction|heart development|structural constituent of muscle|actin cytoskeleton|myosin complex|myofibril|sarcomere|muscle filament sliding|negative regulation of cell growth|A band|myosin heavy chain binding|cardiac myofibril assembly|ventricular cardiac muscle tissue morphogenesis|heart contraction|cardiac myofibril|positive regulation of the force of heart contraction "hsa04260,hsa04261,hsa04371,hsa04510,hsa04530,hsa04670,hsa04810,hsa05131,hsa05132,hsa05410,hsa05414" Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Focal adhesion|Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Salmonella infection|Hypertrophic cardiomyopathy|Dilated cardiomyopathy MYL5 82.26141397 100.4806409 64.04218708 0.637358465 -0.649823088 0.371077571 1 1.90456212 1.266178196 4636 myosin light chain 5 "GO:0005509,GO:0005829,GO:0005859,GO:0006936,GO:0006937,GO:0008307" calcium ion binding|cytosol|muscle myosin complex|muscle contraction|regulation of muscle contraction|structural constituent of muscle "hsa04360,hsa04510,hsa04670,hsa04810,hsa05131,hsa05132" Axon guidance|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Salmonella infection MYL6 17548.25286 16449.39138 18647.11435 1.133605124 0.180918184 0.612603595 1 1176.700061 1391.37279 4637 myosin light chain 6 "GO:0003774,GO:0005509,GO:0005515,GO:0005829,GO:0005903,GO:0006936,GO:0007519,GO:0008307,GO:0016020,GO:0016459,GO:0016461,GO:0030049,GO:0030898,GO:0031982,GO:0070062" motor activity|calcium ion binding|protein binding|cytosol|brush border|muscle contraction|skeletal muscle tissue development|structural constituent of muscle|membrane|myosin complex|unconventional myosin complex|muscle filament sliding|actin-dependent ATPase activity|vesicle|extracellular exosome "hsa04270,hsa04530,hsa04921" Vascular smooth muscle contraction|Tight junction|Oxytocin signaling pathway MYL6B 1839.823445 1942.625723 1737.021166 0.894161518 -0.161392636 0.61946188 1 110.299484 102.873943 140465 myosin light chain 6B "GO:0003774,GO:0005509,GO:0005515,GO:0005829,GO:0005859,GO:0006936,GO:0007519,GO:0008307,GO:0016459,GO:0016461,GO:0030049,GO:0070062" motor activity|calcium ion binding|protein binding|cytosol|muscle myosin complex|muscle contraction|skeletal muscle tissue development|structural constituent of muscle|myosin complex|unconventional myosin complex|muscle filament sliding|extracellular exosome "hsa04270,hsa04530,hsa04921" Vascular smooth muscle contraction|Tight junction|Oxytocin signaling pathway MYL9 5824.24686 5075.794798 6572.698923 1.294910292 0.372852155 0.249818693 1 92.27246956 124.6314812 10398 myosin light chain 9 "GO:0001725,GO:0005509,GO:0005829,GO:0005859,GO:0006936,GO:0006937,GO:0008307,GO:0030018,GO:0032036,GO:0045652,GO:0070527" stress fiber|calcium ion binding|cytosol|muscle myosin complex|muscle contraction|regulation of muscle contraction|structural constituent of muscle|Z disc|myosin heavy chain binding|regulation of megakaryocyte differentiation|platelet aggregation "hsa04022,hsa04024,hsa04270,hsa04360,hsa04510,hsa04530,hsa04670,hsa04810,hsa04921,hsa05131,hsa05132" cGMP-PKG signaling pathway|cAMP signaling pathway|Vascular smooth muscle contraction|Axon guidance|Focal adhesion|Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Shigellosis|Salmonella infection MYLIP 84.68003769 97.43577296 71.92430241 0.738171415 -0.437972223 0.546638795 1 1.535400799 1.182210781 29116 myosin regulatory light chain interacting protein "GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0006511,GO:0007399,GO:0008092,GO:0010977,GO:0010989,GO:0016567,GO:0031648,GO:0032802,GO:0032803,GO:0042632,GO:0045732,GO:0046872,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|cytoskeleton|plasma membrane|ubiquitin-dependent protein catabolic process|nervous system development|cytoskeletal protein binding|negative regulation of neuron projection development|negative regulation of low-density lipoprotein particle clearance|protein ubiquitination|protein destabilization|low-density lipoprotein particle receptor catabolic process|regulation of low-density lipoprotein particle receptor catabolic process|cholesterol homeostasis|positive regulation of protein catabolic process|metal ion binding|ubiquitin protein ligase activity hsa04979 Cholesterol metabolism MYLK 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.028738691 0.0096999 4638 myosin light chain kinase "GO:0001725,GO:0003779,GO:0004672,GO:0004687,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006936,GO:0006939,GO:0014820,GO:0015629,GO:0030027,GO:0030335,GO:0032060,GO:0032154,GO:0046872,GO:0051928,GO:0060414,GO:0071476,GO:0090303" stress fiber|actin binding|protein kinase activity|myosin light chain kinase activity|protein binding|calmodulin binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|muscle contraction|smooth muscle contraction|tonic smooth muscle contraction|actin cytoskeleton|lamellipodium|positive regulation of cell migration|bleb assembly|cleavage furrow|metal ion binding|positive regulation of calcium ion transport|aorta smooth muscle tissue morphogenesis|cellular hypotonic response|positive regulation of wound healing "hsa04020,hsa04022,hsa04270,hsa04371,hsa04510,hsa04611,hsa04810,hsa04921,hsa04971" Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Gastric acid secretion MYLK2 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.055095326 0.018595807 85366 myosin light chain kinase 2 "GO:0004683,GO:0004687,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0006941,GO:0007274,GO:0010628,GO:0014816,GO:0018107,GO:0030017,GO:0032027,GO:0032971,GO:0035914,GO:0045202,GO:0046777,GO:0055008,GO:0060048" calmodulin-dependent protein kinase activity|myosin light chain kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|striated muscle contraction|neuromuscular synaptic transmission|positive regulation of gene expression|skeletal muscle satellite cell differentiation|peptidyl-threonine phosphorylation|sarcomere|myosin light chain binding|regulation of muscle filament sliding|skeletal muscle cell differentiation|synapse|protein autophosphorylation|cardiac muscle tissue morphogenesis|cardiac muscle contraction "hsa04020,hsa04022,hsa04270,hsa04371,hsa04510,hsa04611,hsa04810,hsa04921,hsa04971" Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Gastric acid secretion MYLK4 10.97152057 9.134603715 12.80843742 1.402188624 0.487680435 0.768959523 1 0.054659198 0.079943954 340156 myosin light chain kinase family member 4 "GO:0004687,GO:0005515,GO:0005524,GO:0006468,GO:0106310,GO:0106311" myosin light chain kinase activity|protein binding|ATP binding|protein phosphorylation|protein serine kinase activity|protein threonine kinase activity "hsa04020,hsa04022,hsa04270,hsa04371,hsa04510,hsa04611,hsa04810,hsa04921,hsa04971" Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Gastric acid secretion MYNN 428.6140235 439.4759343 417.7521126 0.950568803 -0.073137041 0.868524762 1 4.419758875 4.382259216 55892 myoneurin "GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0006357,GO:0046872,GO:1990830" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding|cellular response to leukemia inhibitory factor" ZBTB MYO10 3586.469133 4015.165811 3157.772455 0.786461283 -0.346552351 0.276292741 1 14.56899152 11.95150968 4651 myosin X "GO:0001726,GO:0005515,GO:0005516,GO:0005524,GO:0005547,GO:0005730,GO:0005829,GO:0005886,GO:0005938,GO:0008360,GO:0016459,GO:0030027,GO:0030507,GO:0030705,GO:0030898,GO:0031527,GO:0032433,GO:0038096,GO:0051015,GO:0051489,GO:0060002" "ruffle|protein binding|calmodulin binding|ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleolus|cytosol|plasma membrane|cell cortex|regulation of cell shape|myosin complex|lamellipodium|spectrin binding|cytoskeleton-dependent intracellular transport|actin-dependent ATPase activity|filopodium membrane|filopodium tip|Fc-gamma receptor signaling pathway involved in phagocytosis|actin filament binding|regulation of filopodium assembly|plus-end directed microfilament motor activity" "hsa04666,hsa05130" Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection MYO15A 7.986035764 7.104691779 8.867379749 1.248101962 0.319735798 0.916631795 1 0.026452075 0.034437034 51168 myosin XVA "GO:0000146,GO:0005516,GO:0005524,GO:0005737,GO:0007015,GO:0007605,GO:0015629,GO:0016459,GO:0030050,GO:0030898,GO:0031982,GO:0032420,GO:0051015,GO:0070062,GO:0098858" microfilament motor activity|calmodulin binding|ATP binding|cytoplasm|actin filament organization|sensory perception of sound|actin cytoskeleton|myosin complex|vesicle transport along actin filament|actin-dependent ATPase activity|vesicle|stereocilium|actin filament binding|extracellular exosome|actin-based cell projection MYO15B 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.016626163 0.004208754 80022 myosin XVB MYO18A 1426.607951 1410.788796 1442.427106 1.022425972 0.031996389 0.925721744 1 6.898192272 7.356700875 399687 myosin XVIIIA "GO:0000139,GO:0003677,GO:0003723,GO:0005515,GO:0005524,GO:0005793,GO:0005802,GO:0006259,GO:0007030,GO:0009986,GO:0016020,GO:0016459,GO:0016477,GO:0016887,GO:0031032,GO:0042641,GO:0043030,GO:0043066,GO:0043531,GO:0048194,GO:0050714,GO:0051015,GO:0090161,GO:0090164,GO:0150051,GO:1903028" Golgi membrane|DNA binding|RNA binding|protein binding|ATP binding|endoplasmic reticulum-Golgi intermediate compartment|trans-Golgi network|DNA metabolic process|Golgi organization|cell surface|membrane|myosin complex|cell migration|ATPase activity|actomyosin structure organization|actomyosin|regulation of macrophage activation|negative regulation of apoptotic process|ADP binding|Golgi vesicle budding|positive regulation of protein secretion|actin filament binding|Golgi ribbon formation|asymmetric Golgi ribbon formation|postsynaptic Golgi apparatus|positive regulation of opsonization MYO19 2283.786263 1983.223962 2584.348565 1.30310475 0.381953059 0.232690101 1 21.45307503 29.15981801 80179 myosin XIX "GO:0000146,GO:0003779,GO:0005524,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0007015,GO:0015629,GO:0016459,GO:0016887,GO:0030050,GO:0030898,GO:0031982,GO:0032027,GO:0032465,GO:0034642,GO:0051015,GO:0060002,GO:0090140" microfilament motor activity|actin binding|ATP binding|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|actin filament organization|actin cytoskeleton|myosin complex|ATPase activity|vesicle transport along actin filament|actin-dependent ATPase activity|vesicle|myosin light chain binding|regulation of cytokinesis|mitochondrion migration along actin filament|actin filament binding|plus-end directed microfilament motor activity|regulation of mitochondrial fission MYO1B 2437.678778 2568.853556 2306.503999 0.897872903 -0.155416854 0.626865474 1 24.42797038 22.87800652 4430 myosin IB "GO:0000146,GO:0005515,GO:0005516,GO:0005524,GO:0005546,GO:0005547,GO:0005737,GO:0005769,GO:0005884,GO:0005886,GO:0005902,GO:0005903,GO:0006892,GO:0007015,GO:0010008,GO:0015629,GO:0016459,GO:0030048,GO:0030050,GO:0030175,GO:0030898,GO:0031982,GO:0032588,GO:0045177,GO:0045296,GO:0048471,GO:0051015,GO:0051017,GO:0070062,GO:0071944" "microfilament motor activity|protein binding|calmodulin binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|early endosome|actin filament|plasma membrane|microvillus|brush border|post-Golgi vesicle-mediated transport|actin filament organization|endosome membrane|actin cytoskeleton|myosin complex|actin filament-based movement|vesicle transport along actin filament|filopodium|actin-dependent ATPase activity|vesicle|trans-Golgi network membrane|apical part of cell|cadherin binding|perinuclear region of cytoplasm|actin filament binding|actin filament bundle assembly|extracellular exosome|cell periphery" hsa05130 Pathogenic Escherichia coli infection MYO1C 8572.519485 8603.781744 8541.257227 0.992732903 -0.010522485 0.975114729 1 73.78110278 76.4000228 4641 myosin IC "GO:0000146,GO:0001725,GO:0005102,GO:0005515,GO:0005516,GO:0005524,GO:0005643,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0005903,GO:0006605,GO:0006612,GO:0007015,GO:0008022,GO:0009925,GO:0015629,GO:0016020,GO:0016328,GO:0016461,GO:0016604,GO:0030050,GO:0030335,GO:0030659,GO:0030838,GO:0030898,GO:0031267,GO:0031941,GO:0031982,GO:0032587,GO:0038089,GO:0038096,GO:0045121,GO:0045335,GO:0045815,GO:0051015,GO:0051028,GO:0060171,GO:0070062,GO:0071346,GO:0090314,GO:1900078,GO:1900748,GO:2000810" "microfilament motor activity|stress fiber|signaling receptor binding|protein binding|calmodulin binding|ATP binding|nuclear pore|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|microvillus|brush border|protein targeting|protein targeting to membrane|actin filament organization|protein C-terminus binding|basal plasma membrane|actin cytoskeleton|membrane|lateral plasma membrane|unconventional myosin complex|nuclear body|vesicle transport along actin filament|positive regulation of cell migration|cytoplasmic vesicle membrane|positive regulation of actin filament polymerization|actin-dependent ATPase activity|small GTPase binding|filamentous actin|vesicle|ruffle membrane|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|membrane raft|phagocytic vesicle|positive regulation of gene expression, epigenetic|actin filament binding|mRNA transport|stereocilium membrane|extracellular exosome|cellular response to interferon-gamma|positive regulation of protein targeting to membrane|positive regulation of cellular response to insulin stimulus|positive regulation of vascular endothelial growth factor signaling pathway|regulation of bicellular tight junction assembly" hsa05130 Pathogenic Escherichia coli infection MYO1D 1118.119236 999.7316288 1236.506843 1.236838775 0.306657453 0.375569478 1 6.583393598 8.493346503 4642 myosin ID "GO:0000146,GO:0005516,GO:0005524,GO:0005737,GO:0005768,GO:0005769,GO:0005790,GO:0005829,GO:0005886,GO:0005902,GO:0005903,GO:0005938,GO:0007015,GO:0010923,GO:0015031,GO:0015629,GO:0016323,GO:0016459,GO:0019904,GO:0030050,GO:0030424,GO:0030673,GO:0030898,GO:0030900,GO:0031410,GO:0031982,GO:0043005,GO:0043025,GO:0043204,GO:0043209,GO:0044853,GO:0048306,GO:0051015,GO:0051641,GO:0061502,GO:0070062,GO:0097440" microfilament motor activity|calmodulin binding|ATP binding|cytoplasm|endosome|early endosome|smooth endoplasmic reticulum|cytosol|plasma membrane|microvillus|brush border|cell cortex|actin filament organization|negative regulation of phosphatase activity|protein transport|actin cytoskeleton|basolateral plasma membrane|myosin complex|protein domain specific binding|vesicle transport along actin filament|axon|axolemma|actin-dependent ATPase activity|forebrain development|cytoplasmic vesicle|vesicle|neuron projection|neuronal cell body|perikaryon|myelin sheath|plasma membrane raft|calcium-dependent protein binding|actin filament binding|cellular localization|early endosome to recycling endosome transport|extracellular exosome|apical dendrite hsa05130 Pathogenic Escherichia coli infection MYO1E 920.2740832 1012.926056 827.6221099 0.817060737 -0.291484769 0.415475292 1 5.934883314 5.058042285 4643 myosin IE "GO:0000146,GO:0001570,GO:0001701,GO:0003094,GO:0003774,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005856,GO:0005886,GO:0005902,GO:0005903,GO:0005912,GO:0006807,GO:0006897,GO:0007015,GO:0015629,GO:0016459,GO:0016887,GO:0030048,GO:0030050,GO:0030898,GO:0031982,GO:0032836,GO:0035091,GO:0035166,GO:0045334,GO:0048008,GO:0051015,GO:0070062,GO:0072015" microfilament motor activity|vasculogenesis|in utero embryonic development|glomerular filtration|motor activity|protein binding|calmodulin binding|ATP binding|cytoplasm|cytoskeleton|plasma membrane|microvillus|brush border|adherens junction|nitrogen compound metabolic process|endocytosis|actin filament organization|actin cytoskeleton|myosin complex|ATPase activity|actin filament-based movement|vesicle transport along actin filament|actin-dependent ATPase activity|vesicle|glomerular basement membrane development|phosphatidylinositol binding|post-embryonic hemopoiesis|clathrin-coated endocytic vesicle|platelet-derived growth factor receptor signaling pathway|actin filament binding|extracellular exosome|glomerular visceral epithelial cell development hsa05130 Pathogenic Escherichia coli infection MYO1F 14.56840378 19.2841634 9.852644165 0.510918932 -0.9688337 0.444919025 1 0.221017164 0.117786069 4542 myosin IF "GO:0000146,GO:0003779,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0007015,GO:0008150,GO:0015629,GO:0016461,GO:0030050,GO:0030898,GO:0031982,GO:0051015" microfilament motor activity|actin binding|protein binding|calmodulin binding|ATP binding|cytoplasm|cytosol|plasma membrane|microvillus|actin filament organization|biological_process|actin cytoskeleton|unconventional myosin complex|vesicle transport along actin filament|actin-dependent ATPase activity|vesicle|actin filament binding hsa05130 Pathogenic Escherichia coli infection MYO5A 1338.217707 1228.096722 1448.338692 1.179336014 0.237974826 0.480009044 1 5.083675234 6.253617135 4644 myosin VA "GO:0000146,GO:0001726,GO:0003723,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005764,GO:0005769,GO:0005770,GO:0005777,GO:0005783,GO:0005829,GO:0005884,GO:0006892,GO:0007015,GO:0015031,GO:0015629,GO:0016020,GO:0016192,GO:0016459,GO:0030048,GO:0030050,GO:0030426,GO:0030898,GO:0031267,GO:0031982,GO:0032402,GO:0032433,GO:0032593,GO:0032869,GO:0042470,GO:0043005,GO:0051015,GO:0055037,GO:0070062,GO:0072659,GO:1903358" microfilament motor activity|ruffle|RNA binding|protein binding|calmodulin binding|ATP binding|cytoplasm|lysosome|early endosome|late endosome|peroxisome|endoplasmic reticulum|cytosol|actin filament|post-Golgi vesicle-mediated transport|actin filament organization|protein transport|actin cytoskeleton|membrane|vesicle-mediated transport|myosin complex|actin filament-based movement|vesicle transport along actin filament|growth cone|actin-dependent ATPase activity|small GTPase binding|vesicle|melanosome transport|filopodium tip|insulin-responsive compartment|cellular response to insulin stimulus|melanosome|neuron projection|actin filament binding|recycling endosome|extracellular exosome|protein localization to plasma membrane|regulation of Golgi organization hsa05130 Pathogenic Escherichia coli infection MYO5B 31.57027705 36.53841486 26.60213925 0.728059478 -0.457871781 0.655116888 1 0.193106732 0.146649371 4645 myosin VB "GO:0000146,GO:0003091,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0007015,GO:0015031,GO:0015629,GO:0016192,GO:0016197,GO:0016459,GO:0030050,GO:0030659,GO:0030898,GO:0031267,GO:0031982,GO:0032991,GO:0045179,GO:0051015,GO:0055037,GO:0070062" microfilament motor activity|renal water homeostasis|protein binding|calmodulin binding|ATP binding|cytoplasm|actin filament organization|protein transport|actin cytoskeleton|vesicle-mediated transport|endosomal transport|myosin complex|vesicle transport along actin filament|cytoplasmic vesicle membrane|actin-dependent ATPase activity|small GTPase binding|vesicle|protein-containing complex|apical cortex|actin filament binding|recycling endosome|extracellular exosome hsa05130 Pathogenic Escherichia coli infection MYO5C 8.956454404 6.08973581 11.823173 1.941491941 0.957165719 0.543234263 1 0.044180438 0.089470844 55930 myosin VC "GO:0000146,GO:0005516,GO:0005524,GO:0005737,GO:0007015,GO:0015629,GO:0016459,GO:0030050,GO:0030898,GO:0031982,GO:0051015,GO:0070062" microfilament motor activity|calmodulin binding|ATP binding|cytoplasm|actin filament organization|actin cytoskeleton|myosin complex|vesicle transport along actin filament|actin-dependent ATPase activity|vesicle|actin filament binding|extracellular exosome hsa05130 Pathogenic Escherichia coli infection MYO6 1302.68064 1324.517539 1280.843742 0.967026637 -0.048372465 0.888282075 1 7.555145931 7.620741392 4646 myosin VI "GO:0000146,GO:0001726,GO:0003774,GO:0003779,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005765,GO:0005794,GO:0005829,GO:0005884,GO:0005886,GO:0005902,GO:0005905,GO:0005938,GO:0006886,GO:0006897,GO:0007015,GO:0007605,GO:0015629,GO:0016020,GO:0016461,GO:0016591,GO:0030048,GO:0030050,GO:0030139,GO:0030175,GO:0030330,GO:0030665,GO:0030898,GO:0031410,GO:0031941,GO:0031965,GO:0031982,GO:0032587,GO:0042472,GO:0042491,GO:0043531,GO:0045334,GO:0045944,GO:0048471,GO:0051015,GO:0051046,GO:0060001,GO:0070062" "microfilament motor activity|ruffle|motor activity|actin binding|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|lysosomal membrane|Golgi apparatus|cytosol|actin filament|plasma membrane|microvillus|clathrin-coated pit|cell cortex|intracellular protein transport|endocytosis|actin filament organization|sensory perception of sound|actin cytoskeleton|membrane|unconventional myosin complex|RNA polymerase II, holoenzyme|actin filament-based movement|vesicle transport along actin filament|endocytic vesicle|filopodium|DNA damage response, signal transduction by p53 class mediator|clathrin-coated vesicle membrane|actin-dependent ATPase activity|cytoplasmic vesicle|filamentous actin|nuclear membrane|vesicle|ruffle membrane|inner ear morphogenesis|inner ear auditory receptor cell differentiation|ADP binding|clathrin-coated endocytic vesicle|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|actin filament binding|regulation of secretion|minus-end directed microfilament motor activity|extracellular exosome" "hsa05130,hsa05132" Pathogenic Escherichia coli infection|Salmonella infection MYO7A 148.7964536 102.5105528 195.0823545 1.903046556 0.928310856 0.119225994 1 0.584859509 1.160959042 4647 myosin VIIA "GO:0000146,GO:0001750,GO:0001845,GO:0001917,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005765,GO:0005829,GO:0005902,GO:0005938,GO:0006886,GO:0007015,GO:0007040,GO:0007423,GO:0007601,GO:0007605,GO:0015629,GO:0016324,GO:0019904,GO:0030048,GO:0030050,GO:0030507,GO:0030898,GO:0031477,GO:0031982,GO:0032391,GO:0032420,GO:0034613,GO:0042462,GO:0042470,GO:0042490,GO:0042802,GO:0043531,GO:0045202,GO:0047485,GO:0048563,GO:0050953,GO:0050957,GO:0051015,GO:0051904,GO:0060088,GO:0120044,GO:1990435" microfilament motor activity|photoreceptor outer segment|phagolysosome assembly|photoreceptor inner segment|protein binding|calmodulin binding|ATP binding|cytoplasm|lysosomal membrane|cytosol|microvillus|cell cortex|intracellular protein transport|actin filament organization|lysosome organization|sensory organ development|visual perception|sensory perception of sound|actin cytoskeleton|apical plasma membrane|protein domain specific binding|actin filament-based movement|vesicle transport along actin filament|spectrin binding|actin-dependent ATPase activity|myosin VII complex|vesicle|photoreceptor connecting cilium|stereocilium|cellular protein localization|eye photoreceptor cell development|melanosome|mechanoreceptor differentiation|identical protein binding|ADP binding|synapse|protein N-terminus binding|post-embryonic animal organ morphogenesis|sensory perception of light stimulus|equilibrioception|actin filament binding|pigment granule transport|auditory receptor cell stereocilium organization|stereocilium base|upper tip-link density MYO9A 1588.162861 1577.241575 1599.084148 1.013848591 0.019842215 0.953978616 1 6.14995162 6.503703457 4649 myosin IXA "GO:0003774,GO:0003779,GO:0005096,GO:0005515,GO:0005524,GO:0005829,GO:0007601,GO:0016021,GO:0016461,GO:0034329,GO:0035556,GO:0043547,GO:0044295,GO:0045198,GO:0045202,GO:0046872,GO:0051056,GO:0150011" motor activity|actin binding|GTPase activator activity|protein binding|ATP binding|cytosol|visual perception|integral component of membrane|unconventional myosin complex|cell junction assembly|intracellular signal transduction|positive regulation of GTPase activity|axonal growth cone|establishment of epithelial cell apical/basal polarity|synapse|metal ion binding|regulation of small GTPase mediated signal transduction|regulation of neuron projection arborization MYO9B 3036.223943 2972.806031 3099.641854 1.042665354 0.060276196 0.850564255 1 19.79517987 21.52882488 4650 myosin IXB "GO:0000146,GO:0003779,GO:0005096,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0005884,GO:0005938,GO:0007266,GO:0015629,GO:0016020,GO:0016459,GO:0016887,GO:0030048,GO:0031267,GO:0032011,GO:0035023,GO:0035385,GO:0042803,GO:0043531,GO:0043547,GO:0046872,GO:0048471,GO:0048495,GO:0051056" microfilament motor activity|actin binding|GTPase activator activity|protein binding|calmodulin binding|ATP binding|cytoplasm|cytosol|actin filament|cell cortex|Rho protein signal transduction|actin cytoskeleton|membrane|myosin complex|ATPase activity|actin filament-based movement|small GTPase binding|ARF protein signal transduction|regulation of Rho protein signal transduction|Roundabout signaling pathway|protein homodimerization activity|ADP binding|positive regulation of GTPase activity|metal ion binding|perinuclear region of cytoplasm|Roundabout binding|regulation of small GTPase mediated signal transduction MYOF 12336.94786 12256.60827 12417.28744 1.013109595 0.018790248 0.956557059 1 73.16760612 77.31988587 26509 myoferlin "GO:0001778,GO:0005515,GO:0005543,GO:0005635,GO:0005886,GO:0005901,GO:0006936,GO:0007009,GO:0007520,GO:0008015,GO:0016021,GO:0030659,GO:0031410,GO:0031965,GO:0033292,GO:0043231,GO:0046872,GO:0061025,GO:0070062" plasma membrane repair|protein binding|phospholipid binding|nuclear envelope|plasma membrane|caveola|muscle contraction|plasma membrane organization|myoblast fusion|blood circulation|integral component of membrane|cytoplasmic vesicle membrane|cytoplasmic vesicle|nuclear membrane|T-tubule organization|intracellular membrane-bounded organelle|metal ion binding|membrane fusion|extracellular exosome MYOM1 4.463381426 2.029911937 6.896850916 3.397610897 1.764520641 0.414871268 1 0.018325825 0.064946104 8736 myomesin 1 "GO:0002074,GO:0005515,GO:0005863,GO:0006936,GO:0008307,GO:0010628,GO:0010737,GO:0019900,GO:0031430,GO:0042802,GO:0042803,GO:0050714,GO:0051015" extraocular skeletal muscle development|protein binding|striated muscle myosin thick filament|muscle contraction|structural constituent of muscle|positive regulation of gene expression|protein kinase A signaling|kinase binding|M band|identical protein binding|protein homodimerization activity|positive regulation of protein secretion|actin filament binding MYOM2 10.52342568 12.17947162 8.867379749 0.728059478 -0.457871781 0.792994139 1 0.123172378 0.093539731 9172 myomesin 2 "GO:0002074,GO:0005515,GO:0005739,GO:0006936,GO:0008307,GO:0019900,GO:0031430,GO:0032982,GO:0051015" extraocular skeletal muscle development|protein binding|mitochondrion|muscle contraction|structural constituent of muscle|kinase binding|M band|myosin filament|actin filament binding MYOM3 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.044621475 0.045182 127294 myomesin 3 "GO:0006936,GO:0031430,GO:0042803,GO:0051015" muscle contraction|M band|protein homodimerization activity|actin filament binding MYORG 820.3454576 816.0245986 824.6663166 1.010590022 0.01519784 0.970501576 1 5.386259241 5.677775124 57462 myogenesis regulating glycosidase (putative) "GO:0004553,GO:0005789,GO:0005975,GO:0016021,GO:0031965,GO:0043568,GO:0048741,GO:0051897" "hydrolase activity, hydrolyzing O-glycosyl compounds|endoplasmic reticulum membrane|carbohydrate metabolic process|integral component of membrane|nuclear membrane|positive regulation of insulin-like growth factor receptor signaling pathway|skeletal muscle fiber development|positive regulation of protein kinase B signaling" MYOZ1 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.23724895 0.080076406 58529 myozenin 1 "GO:0000122,GO:0003779,GO:0004865,GO:0005515,GO:0005634,GO:0007519,GO:0015629,GO:0030018,GO:0030239,GO:0031143,GO:0031433,GO:0032515,GO:0042060,GO:0043417,GO:0043503,GO:0045214,GO:0051373,GO:0070885" negative regulation of transcription by RNA polymerase II|actin binding|protein serine/threonine phosphatase inhibitor activity|protein binding|nucleus|skeletal muscle tissue development|actin cytoskeleton|Z disc|myofibril assembly|pseudopodium|telethonin binding|negative regulation of phosphoprotein phosphatase activity|wound healing|negative regulation of skeletal muscle tissue regeneration|skeletal muscle fiber adaptation|sarcomere organization|FATZ binding|negative regulation of calcineurin-NFAT signaling cascade MYPN 22.06180734 26.38885518 17.7347595 0.672054903 -0.573348998 0.615558482 1 0.197153329 0.138205332 84665 myopalladin "GO:0003779,GO:0005515,GO:0005634,GO:0005886,GO:0007156,GO:0007411,GO:0008092,GO:0017124,GO:0030018,GO:0030424,GO:0031674,GO:0045214,GO:0051371,GO:0070593,GO:0098632" actin binding|protein binding|nucleus|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|cytoskeletal protein binding|SH3 domain binding|Z disc|axon|I band|sarcomere organization|muscle alpha-actinin binding|dendrite self-avoidance|cell-cell adhesion mediator activity MYPOP 159.8097899 148.1835714 171.4360085 1.156916431 0.210284656 0.724106322 1 2.530335513 3.053486677 339344 "Myb related transcription factor, partner of profilin" "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0042802" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding" MYRF 714.1217309 929.699667 498.5437948 0.53624177 -0.899044495 0.017350577 0.570800302 7.605557802 4.254099473 745 myelin regulatory factor "GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0006357,GO:0008233,GO:0014003,GO:0016021,GO:0016540,GO:0022010,GO:0031643,GO:0032286,GO:0043565,GO:0045893,GO:0048709" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|peptidase activity|oligodendrocyte development|integral component of membrane|protein autoprocessing|central nervous system myelination|positive regulation of myelination|central nervous system myelin maintenance|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|oligodendrocyte differentiation" MYSM1 994.3997659 927.6697551 1061.129777 1.143865876 0.193917898 0.583540862 1 6.019628504 7.182253403 114803 "Myb like, SWIRM and MPN domains 1" "GO:0003677,GO:0003713,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006338,GO:0008237,GO:0016579,GO:0018215,GO:0032991,GO:0035522,GO:0042393,GO:0045944,GO:0046872,GO:0070122,GO:1903706" DNA binding|transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|nucleolus|chromatin remodeling|metallopeptidase activity|protein deubiquitination|protein phosphopantetheinylation|protein-containing complex|monoubiquitinated histone H2A deubiquitination|histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding|isopeptidase activity|regulation of hemopoiesis MYT1 6.015506931 7.104691779 4.926322083 0.693389979 -0.528261108 0.84291128 1 0.064752128 0.046832521 4661 myelin transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0007399,GO:0008270,GO:0030154" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nervous system development|zinc ion binding|cell differentiation" MYZAP 25.37662081 17.25425146 33.49899016 1.941491941 0.957165719 0.362494371 1 0.364414915 0.737985224 100820829 myocardial zonula adherens protein "GO:0005515,GO:0005622,GO:0030018,GO:0030054,GO:0030864,GO:0031234,GO:0031674,GO:0035556" protein binding|intracellular anatomical structure|Z disc|cell junction|cortical actin cytoskeleton|extrinsic component of cytoplasmic side of plasma membrane|I band|intracellular signal transduction MZF1 307.0486749 312.6064383 301.4909115 0.964442425 -0.052232979 0.918407216 1 3.913102642 3.936529188 7593 myeloid zinc finger 1 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005654,GO:0006355,GO:0042803,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|protein homodimerization activity|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 MZT1 407.8155909 297.3820987 518.2490831 1.74270437 0.801327854 0.063873543 1 6.750943164 12.27168225 440145 mitotic spindle organizing protein 1 "GO:0005515,GO:0005813,GO:0005819,GO:0005829,GO:0008274,GO:0031021,GO:0033566,GO:0051415,GO:0090307" protein binding|centrosome|spindle|cytosol|gamma-tubulin ring complex|interphase microtubule organizing center|gamma-tubulin complex localization|microtubule nucleation by interphase microtubule organizing center|mitotic spindle assembly MZT2A 582.331356 608.973581 555.6891309 0.912501212 -0.132101619 0.740151144 1 9.671484336 9.20539678 653784 mitotic spindle organizing protein 2A "GO:0005515,GO:0005654,GO:0005813,GO:0005819,GO:0005829,GO:0008274" protein binding|nucleoplasm|centrosome|spindle|cytosol|gamma-tubulin ring complex MZT2B 1601.141283 1689.901687 1512.380879 0.894951991 -0.160117803 0.627230538 1 109.8684966 102.5625594 80097 mitotic spindle organizing protein 2B "GO:0005515,GO:0005654,GO:0005813,GO:0005819,GO:0005829,GO:0008274" protein binding|nucleoplasm|centrosome|spindle|cytosol|gamma-tubulin ring complex N4BP1 696.530232 636.3773922 756.6830719 1.189047696 0.249806587 0.509872057 1 4.554227767 5.64845863 9683 NEDD4 binding protein 1 "GO:0005515,GO:0005634,GO:0005730,GO:0016605,GO:0031397,GO:0032435,GO:0034644" protein binding|nucleus|nucleolus|PML body|negative regulation of protein ubiquitination|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to UV N4BP2 277.1789811 291.2923629 263.0655992 0.903098168 -0.147045276 0.767153614 1 1.179951257 1.111514053 55728 NEDD4 binding protein 2 "GO:0004519,GO:0005515,GO:0005524,GO:0005829,GO:0016310,GO:0043130,GO:0046404,GO:0090305" endonuclease activity|protein binding|ATP binding|cytosol|phosphorylation|ubiquitin binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|nucleic acid phosphodiester bond hydrolysis N4BP2L1 74.81526935 62.92727004 86.70326866 1.37783299 0.462401027 0.541636938 1 0.552922317 0.794651354 90634 NEDD4 binding protein 2 like 1 N4BP2L2 996.9129074 863.7275291 1130.098286 1.308396743 0.387800073 0.271528641 1 3.511378416 4.792178863 10443 NEDD4 binding protein 2 like 2 "GO:0000122,GO:0003674,GO:0003714,GO:0005515,GO:0005634,GO:0017053,GO:0019899,GO:0070062,GO:1902035,GO:1902037" negative regulation of transcription by RNA polymerase II|molecular_function|transcription corepressor activity|protein binding|nucleus|transcription repressor complex|enzyme binding|extracellular exosome|positive regulation of hematopoietic stem cell proliferation|negative regulation of hematopoietic stem cell differentiation N4BP3 221.2079451 169.4976467 272.9182434 1.610159484 0.687203592 0.188252233 1 1.232690674 2.070326945 23138 NEDD4 binding protein 3 "GO:0005515,GO:0007399,GO:0030424,GO:0030425,GO:0031410" protein binding|nervous system development|axon|dendrite|cytoplasmic vesicle N6AMT1 147.1498103 158.3331311 135.9664895 0.85873682 -0.219712043 0.719846206 1 1.649663551 1.477649371 29104 N-6 adenine-specific DNA methyltransferase 1 "GO:0003676,GO:0005515,GO:0005634,GO:0005829,GO:0006415,GO:0008276,GO:0008757,GO:0009007,GO:0009404,GO:0018024,GO:0018364,GO:0018872,GO:0030307,GO:0030792,GO:0032259,GO:0032775,GO:0032991,GO:0034968,GO:0035657,GO:0036009,GO:1904047" nucleic acid binding|protein binding|nucleus|cytosol|translational termination|protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|site-specific DNA-methyltransferase (adenine-specific) activity|toxin metabolic process|histone-lysine N-methyltransferase activity|peptidyl-glutamine methylation|arsonoacetate metabolic process|positive regulation of cell growth|methylarsonite methyltransferase activity|methylation|DNA methylation on adenine|protein-containing complex|histone lysine methylation|eRF1 methyltransferase complex|protein-glutamine N-methyltransferase activity|S-adenosyl-L-methionine binding NAA10 1844.551329 1996.41839 1692.684268 0.847860487 -0.238101202 0.4631144 1 63.07644947 55.78373191 8260 "N-alpha-acetyltransferase 10, NatA catalytic subunit" "GO:0004596,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006323,GO:0006473,GO:0006474,GO:0006475,GO:0008080,GO:0016020,GO:0016407,GO:0017198,GO:0018002,GO:0031415,GO:0043022,GO:1990189,GO:1990190,GO:2000719" "peptide alpha-N-acetyltransferase activity|protein binding|nucleus|nucleolus|cytoplasm|cytosol|DNA packaging|protein acetylation|N-terminal protein amino acid acetylation|internal protein amino acid acetylation|N-acetyltransferase activity|membrane|acetyltransferase activity|N-terminal peptidyl-serine acetylation|N-terminal peptidyl-glutamic acid acetylation|NatA complex|ribosome binding|peptide-serine-N-acetyltransferase activity|peptide-glutamate-N-acetyltransferase activity|negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric" NAA15 1174.078148 1087.017842 1261.138453 1.160181926 0.214351049 0.532972696 1 8.908352578 10.78051287 80155 "N-alpha-acetyltransferase 15, NatA auxiliary subunit" "GO:0001525,GO:0003723,GO:0004596,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0005829,GO:0006474,GO:0016020,GO:0016407,GO:0016604,GO:0017196,GO:0030154,GO:0031415,GO:0043022,GO:0043066,GO:0043231,GO:0045893,GO:0050821" "angiogenesis|RNA binding|peptide alpha-N-acetyltransferase activity|protein binding|nucleus|transcription regulator complex|cytoplasm|cytosol|N-terminal protein amino acid acetylation|membrane|acetyltransferase activity|nuclear body|N-terminal peptidyl-methionine acetylation|cell differentiation|NatA complex|ribosome binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|protein stabilization" NAA16 211.6940321 226.3351809 197.0528833 0.870624189 -0.199877991 0.711259952 1 1.678588146 1.524371466 79612 "N-alpha-acetyltransferase 16, NatA auxiliary subunit" "GO:0004596,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0005829,GO:0006474,GO:0016407,GO:0017196,GO:0031415,GO:0043022,GO:0043066,GO:0045893,GO:0050821,GO:0070062" "peptide alpha-N-acetyltransferase activity|protein binding|nucleus|transcription regulator complex|cytoplasm|cytosol|N-terminal protein amino acid acetylation|acetyltransferase activity|N-terminal peptidyl-methionine acetylation|NatA complex|ribosome binding|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|protein stabilization|extracellular exosome" NAA20 1683.58233 1600.585562 1766.579099 1.103708006 0.142358547 0.664345621 1 60.81321245 70.01128809 51126 "N-alpha-acetyltransferase 20, NatB catalytic subunit" "GO:0004596,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0017196,GO:0031416" peptide alpha-N-acetyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|N-terminal peptidyl-methionine acetylation|NatB complex NAA25 831.4869627 937.8193148 725.1546106 0.773234886 -0.371021367 0.309016339 1 7.324169601 5.907255588 80018 "N-alpha-acetyltransferase 25, NatB auxiliary subunit" "GO:0004596,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0017196,GO:0031416" peptide alpha-N-acetyltransferase activity|protein binding|cytoplasm|Golgi apparatus|cytosol|N-terminal peptidyl-methionine acetylation|NatB complex NAA30 636.7584313 625.2128765 648.3039861 1.036933196 0.052322952 0.896013011 1 4.16642455 4.506405095 122830 "N-alpha-acetyltransferase 30, NatC catalytic subunit" "GO:0004596,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0017196,GO:0031417" peptide alpha-N-acetyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|polysome|N-terminal peptidyl-methionine acetylation|NatC complex NAA35 989.1683634 1007.851277 970.4854503 0.962925258 -0.054504274 0.879955816 1 7.056139297 7.087215752 60560 "N-alpha-acetyltransferase 35, NatC auxiliary subunit" "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0005886,GO:0006474,GO:0017196,GO:0031417,GO:0043066,GO:0048659" protein binding|nucleoplasm|cytoplasm|cytosol|polysome|plasma membrane|N-terminal protein amino acid acetylation|N-terminal peptidyl-methionine acetylation|NatC complex|negative regulation of apoptotic process|smooth muscle cell proliferation NAA38 731.6177202 744.9776808 718.2577597 0.96413326 -0.05269553 0.891480102 1 32.55434979 32.73874447 84316 "N-alpha-acetyltransferase 38, NatC auxiliary subunit" "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005844,GO:0031417,GO:0043066" protein binding|nucleus|nucleoplasm|cytoplasm|polysome|NatC complex|negative regulation of apoptotic process NAA40 1406.041608 1351.92135 1460.161865 1.08006421 0.111117084 0.740961513 1 17.2947833 19.48411256 79829 "N-alpha-acetyltransferase 40, NatD catalytic subunit" "GO:0005515,GO:0005654,GO:0005829,GO:0006474,GO:0006629,GO:0010485,GO:0034451,GO:0043967,GO:0043968,GO:0043998,GO:1990189" protein binding|nucleoplasm|cytosol|N-terminal protein amino acid acetylation|lipid metabolic process|H4 histone acetyltransferase activity|centriolar satellite|histone H4 acetylation|histone H2A acetylation|H2A histone acetyltransferase activity|peptide-serine-N-acetyltransferase activity NAA50 2858.484915 3013.40427 2703.565559 0.897179839 -0.156530893 0.623266258 1 24.97027088 23.3678464 80218 "N-alpha-acetyltransferase 50, NatE catalytic subunit" "GO:0004596,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006474,GO:0007064,GO:0008080,GO:0010485,GO:0016573,GO:0031415,GO:0034087,GO:0043967,GO:0052858,GO:0070062,GO:0071962" "peptide alpha-N-acetyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|N-terminal protein amino acid acetylation|mitotic sister chromatid cohesion|N-acetyltransferase activity|H4 histone acetyltransferase activity|histone acetylation|NatA complex|establishment of mitotic sister chromatid cohesion|histone H4 acetylation|peptidyl-lysine acetyltransferase activity|extracellular exosome|mitotic sister chromatid cohesion, centromeric" NAA60 705.0331484 712.4990898 697.5672069 0.979042945 -0.030555951 0.939342161 1 11.01849324 11.25226318 79903 "N-alpha-acetyltransferase 60, NatF catalytic subunit" "GO:0000139,GO:0004402,GO:0004596,GO:0005515,GO:0006334,GO:0006474,GO:0007059,GO:0008283,GO:0010485,GO:0017196,GO:0042803,GO:0043966,GO:0043967" Golgi membrane|histone acetyltransferase activity|peptide alpha-N-acetyltransferase activity|protein binding|nucleosome assembly|N-terminal protein amino acid acetylation|chromosome segregation|cell population proliferation|H4 histone acetyltransferase activity|N-terminal peptidyl-methionine acetylation|protein homodimerization activity|histone H3 acetylation|histone H4 acetylation NAA80 161.8572692 119.7648043 203.9497342 1.702918779 0.768009627 0.184465962 1 4.46332953 7.928094472 24142 "N-alpha-acetyltransferase 80, NatH catalytic subunit" "GO:0004596,GO:0005737,GO:0005829,GO:0006473,GO:0008064,GO:0008080,GO:0017190,GO:0018002,GO:0030047,GO:1905502" peptide alpha-N-acetyltransferase activity|cytoplasm|cytosol|protein acetylation|regulation of actin polymerization or depolymerization|N-acetyltransferase activity|N-terminal peptidyl-aspartic acid acetylation|N-terminal peptidyl-glutamic acid acetylation|actin modification|acetyl-CoA binding NAAA 370.6521696 383.653356 357.6509832 0.932224305 -0.101250967 0.824431765 1 4.76475945 4.633160355 27163 N-acylethanolamine acid amidase "GO:0005737,GO:0005764,GO:0006631,GO:0006670,GO:0007269,GO:0008134,GO:0016042,GO:0016810,GO:0017040,GO:0017064,GO:0019898,GO:0043202,GO:0047412,GO:0070062,GO:0070291,GO:0070292,GO:0098793,GO:0102121" "cytoplasm|lysosome|fatty acid metabolic process|sphingosine metabolic process|neurotransmitter secretion|transcription factor binding|lipid catabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|N-acylsphingosine amidohydrolase activity|fatty acid amide hydrolase activity|extrinsic component of membrane|lysosomal lumen|N-(long-chain-acyl)ethanolamine deacylase activity|extracellular exosome|N-acylethanolamine metabolic process|N-acylphosphatidylethanolamine metabolic process|presynapse|ceramidase activity" NAALAD2 83.32362887 72.06187375 94.58538399 1.312557932 0.3923811 0.592987495 1 0.983476068 1.346474728 10003 N-acetylated alpha-linked acidic dipeptidase 2 "GO:0004180,GO:0004181,GO:0005515,GO:0005886,GO:0006508,GO:0008236,GO:0008239,GO:0008652,GO:0016021,GO:0016805,GO:0046872" carboxypeptidase activity|metallocarboxypeptidase activity|protein binding|plasma membrane|proteolysis|serine-type peptidase activity|dipeptidyl-peptidase activity|cellular amino acid biosynthetic process|integral component of membrane|dipeptidase activity|metal ion binding NAB1 1295.338416 1294.06886 1296.607972 1.001962115 0.002827961 0.995939701 1 13.01430154 13.6015404 4664 NGFI-A binding protein 1 "GO:0001958,GO:0003712,GO:0005634,GO:0006355,GO:0008134,GO:0014037,GO:0042552,GO:0045682,GO:0045892" "endochondral ossification|transcription coregulator activity|nucleus|regulation of transcription, DNA-templated|transcription factor binding|Schwann cell differentiation|myelination|regulation of epidermis development|negative regulation of transcription, DNA-templated" NAB2 998.0951263 1011.9111 984.2791521 0.972693304 -0.039943108 0.912587678 1 20.57395722 20.87419271 4665 NGFI-A binding protein 2 "GO:0001958,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0006355,GO:0008134,GO:0014037,GO:0016480,GO:0042552,GO:0042802,GO:0045682,GO:1902949" "endochondral ossification|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|regulation of transcription, DNA-templated|transcription factor binding|Schwann cell differentiation|negative regulation of transcription by RNA polymerase III|myelination|identical protein binding|regulation of epidermis development|positive regulation of tau-protein kinase activity" NABP1 316.5126072 319.71113 313.3140845 0.97999117 -0.029159344 0.957324817 1 8.970770561 9.169968454 64859 nucleic acid binding protein 1 "GO:0000724,GO:0000781,GO:0003677,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0007093,GO:0010212,GO:0035861,GO:0042795,GO:0044818,GO:0070876" "double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|single-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|mitotic cell cycle checkpoint|response to ionizing radiation|site of double-strand break|snRNA transcription by RNA polymerase II|mitotic G2/M transition checkpoint|SOSS complex" NABP2 1317.231477 1376.280293 1258.18266 0.914190711 -0.129432935 0.702481136 1 40.59623857 38.71136899 79035 nucleic acid binding protein 2 "GO:0000724,GO:0000781,GO:0003677,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0007093,GO:0010212,GO:0035861,GO:0042795,GO:0044818,GO:0051972,GO:0061730,GO:0070182,GO:0070200,GO:0070876,GO:0098505,GO:1904355" "double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|mitotic cell cycle checkpoint|response to ionizing radiation|site of double-strand break|snRNA transcription by RNA polymerase II|mitotic G2/M transition checkpoint|regulation of telomerase activity|C-rich strand telomeric DNA binding|DNA polymerase binding|establishment of protein localization to telomere|SOSS complex|G-rich strand telomeric DNA binding|positive regulation of telomere capping" NACA 9577.177682 10232.78607 8921.569292 0.871861214 -0.197829594 0.555168508 1 77.19012742 70.19804958 4666 nascent polypeptide associated complex subunit alpha "GO:0003677,GO:0005634,GO:0005737,GO:0005854,GO:0006612,GO:0051082" DNA binding|nucleus|cytoplasm|nascent polypeptide-associated complex|protein targeting to membrane|unfolded protein binding hsa04928 "Parathyroid hormone synthesis, secretion and action" NACA2 19.9725123 18.26920743 21.67581716 1.186467297 0.246672336 0.865811425 1 1.158036178 1.433157198 342538 nascent polypeptide associated complex subunit alpha 2 "GO:0005634,GO:0005737,GO:0005854,GO:0006612,GO:0051082" nucleus|cytoplasm|nascent polypeptide-associated complex|protein targeting to membrane|unfolded protein binding NACC1 2560.445396 2609.451795 2511.438998 0.962439315 -0.055232518 0.863534777 1 27.82305849 27.93149322 112939 nucleus accumbens associated 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0008284,GO:0030054,GO:0042826,GO:0043231,GO:0045892" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|cell junction|histone deacetylase binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated" NACC2 1867.602606 1787.33746 1947.867752 1.089815323 0.124083681 0.702609761 1 12.8949198 14.65843093 138151 NACC family member 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005730,GO:0005739,GO:0006357,GO:0008285,GO:0034629,GO:0042803,GO:0042826,GO:0044877,GO:0045892,GO:0051260,GO:1900477,GO:1902231" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleolus|mitochondrion|regulation of transcription by RNA polymerase II|negative regulation of cell population proliferation|cellular protein-containing complex localization|protein homodimerization activity|histone deacetylase binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|protein homooligomerization|negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage" NADK 1523.885864 1527.508732 1520.262995 0.9952565 -0.006859706 0.985688351 1 16.83632831 17.47826575 65220 NAD kinase "GO:0003951,GO:0005515,GO:0005524,GO:0005829,GO:0006741,GO:0016310,GO:0019674,GO:0035774,GO:0046034,GO:0046872" NAD+ kinase activity|protein binding|ATP binding|cytosol|NADP biosynthetic process|phosphorylation|NAD metabolic process|positive regulation of insulin secretion involved in cellular response to glucose stimulus|ATP metabolic process|metal ion binding hsa00760 Nicotinate and nicotinamide metabolism NADK2 536.3681028 598.8240213 473.9121844 0.791404766 -0.337512342 0.4012747 1 6.899072829 5.695152012 133686 "NAD kinase 2, mitochondrial" "GO:0003951,GO:0005524,GO:0005739,GO:0005759,GO:0006741,GO:0016310,GO:0019674,GO:0042803" NAD+ kinase activity|ATP binding|mitochondrion|mitochondrial matrix|NADP biosynthetic process|phosphorylation|NAD metabolic process|protein homodimerization activity hsa00760 Nicotinate and nicotinamide metabolism NADSYN1 549.7785361 538.9416192 560.615453 1.04021555 0.05688251 0.891041741 1 10.18868673 11.05496777 55191 NAD synthetase 1 "GO:0003952,GO:0004359,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0009435,GO:0019674,GO:0034627" NAD+ synthase (glutamine-hydrolyzing) activity|glutaminase activity|protein binding|ATP binding|cytoplasm|cytosol|NAD biosynthetic process|NAD metabolic process|'de novo' NAD biosynthetic process hsa00760 Nicotinate and nicotinamide metabolism NAE1 1063.048349 1006.836321 1119.260377 1.111660708 0.152716528 0.662828154 1 26.55870194 30.79605103 8883 NEDD8 activating enzyme E1 subunit 1 "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0018215,GO:0019781,GO:0031625,GO:0032446,GO:0032991,GO:0033314,GO:0042981,GO:0043523,GO:0043687,GO:0045116,GO:0046982,GO:0051402" protein binding|cytoplasm|cytosol|plasma membrane|signal transduction|protein phosphopantetheinylation|NEDD8 activating enzyme activity|ubiquitin protein ligase binding|protein modification by small protein conjugation|protein-containing complex|mitotic DNA replication checkpoint|regulation of apoptotic process|regulation of neuron apoptotic process|post-translational protein modification|protein neddylation|protein heterodimerization activity|neuron apoptotic process hsa05010 Alzheimer disease NAF1 391.6005438 333.9205136 449.2805739 1.345471619 0.428111959 0.327026159 1 2.783393024 3.906294709 92345 nuclear assembly factor 1 ribonucleoprotein "GO:0000454,GO:0000493,GO:0003723,GO:0005515,GO:0005654,GO:0005732,GO:0005737,GO:0032212,GO:0042254,GO:0042802,GO:0043489,GO:0051973,GO:0070034,GO:0090669,GO:1904358,GO:1904874,GO:1905323" snoRNA guided rRNA pseudouridine synthesis|box H/ACA snoRNP assembly|RNA binding|protein binding|nucleoplasm|sno(s)RNA-containing ribonucleoprotein complex|cytoplasm|positive regulation of telomere maintenance via telomerase|ribosome biogenesis|identical protein binding|RNA stabilization|positive regulation of telomerase activity|telomerase RNA binding|telomerase RNA stabilization|positive regulation of telomere maintenance via telomere lengthening|positive regulation of telomerase RNA localization to Cajal body|telomerase holoenzyme complex assembly NAGA 1721.883433 1659.453008 1784.313858 1.075242173 0.104661629 0.749627579 1 22.55647898 25.29842753 4668 alpha-N-acetylgalactosaminidase "GO:0004557,GO:0005737,GO:0005764,GO:0008456,GO:0009311,GO:0016052,GO:0016139,GO:0019377,GO:0042803,GO:0046477,GO:0070062" alpha-galactosidase activity|cytoplasm|lysosome|alpha-N-acetylgalactosaminidase activity|oligosaccharide metabolic process|carbohydrate catabolic process|glycoside catabolic process|glycolipid catabolic process|protein homodimerization activity|glycosylceramide catabolic process|extracellular exosome "hsa00603,hsa04142" Glycosphingolipid biosynthesis - globo and isoglobo series|Lysosome NAGK 671.5665713 681.0354548 662.0976879 0.972192686 -0.040685815 0.918912229 1 17.93657995 18.18896204 55577 N-acetylglucosamine kinase "GO:0005515,GO:0005524,GO:0005829,GO:0006044,GO:0006048,GO:0006051,GO:0019262,GO:0045127,GO:0046835,GO:0070062" protein binding|ATP binding|cytosol|N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylmannosamine metabolic process|N-acetylneuraminate catabolic process|N-acetylglucosamine kinase activity|carbohydrate phosphorylation|extracellular exosome hsa00520 Amino sugar and nucleotide sugar metabolism NAGLU 730.3961612 897.221076 563.5712463 0.628129746 -0.670865504 0.073536354 1 9.097313773 5.96044197 4669 N-acetyl-alpha-glucosaminidase "GO:0004561,GO:0005764,GO:0006027,GO:0007040,GO:0007399,GO:0021680,GO:0042474,GO:0043202,GO:0045475,GO:0046548,GO:0060119,GO:0070062" alpha-N-acetylglucosaminidase activity|lysosome|glycosaminoglycan catabolic process|lysosome organization|nervous system development|cerebellar Purkinje cell layer development|middle ear morphogenesis|lysosomal lumen|locomotor rhythm|retinal rod cell development|inner ear receptor cell development|extracellular exosome "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome NAGPA 273.1785403 287.232539 259.1245416 0.902142015 -0.148573535 0.765873381 1 6.588457793 6.199756139 51172 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase "GO:0003944,GO:0005515,GO:0005975,GO:0006464,GO:0006486,GO:0006622,GO:0007040,GO:0016021,GO:0032580,GO:0033299" N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity|protein binding|carbohydrate metabolic process|cellular protein modification process|protein glycosylation|protein targeting to lysosome|lysosome organization|integral component of membrane|Golgi cisterna membrane|secretion of lysosomal enzymes hsa04142 Lysosome NAGS 160.243039 144.1237475 176.3623306 1.223686822 0.291234377 0.62050497 1 3.026268397 3.862723799 162417 N-acetylglutamate synthase "GO:0000050,GO:0003991,GO:0004042,GO:0005739,GO:0005759,GO:0006526,GO:0006536,GO:0016310,GO:0034618,GO:0103045" urea cycle|acetylglutamate kinase activity|acetyl-CoA:L-glutamate N-acetyltransferase activity|mitochondrion|mitochondrial matrix|arginine biosynthetic process|glutamate metabolic process|phosphorylation|arginine binding|methione N-acyltransferase activity hsa00220 Arginine biosynthesis NAIF1 232.530321 269.9782876 195.0823545 0.722585346 -0.468760097 0.362050062 1 4.023969347 3.03291154 203245 nuclear apoptosis inducing factor 1 "GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0005886,GO:0030308,GO:1902108" molecular_function|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|plasma membrane|negative regulation of cell growth|regulation of mitochondrial membrane permeability involved in apoptotic process NAIP 16.39047486 9.134603715 23.646346 2.588655921 1.372203218 0.254334037 1 0.060443618 0.163207725 4671 NLR family apoptosis inhibitory protein "GO:0005515,GO:0005524,GO:0005737,GO:0006915,GO:0006954,GO:0007399,GO:0016045,GO:0016323,GO:0042742,GO:0043027,GO:0043066,GO:0043154,GO:0043524,GO:0045087,GO:0046872,GO:0070269,GO:0072557" protein binding|ATP binding|cytoplasm|apoptotic process|inflammatory response|nervous system development|detection of bacterium|basolateral plasma membrane|defense response to bacterium|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of neuron apoptotic process|innate immune response|metal ion binding|pyroptosis|IPAF inflammasome complex "hsa04621,hsa05130,hsa05131,hsa05132,hsa05134" NOD-like receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Legionellosis NALCN 113.4132877 142.0938356 84.73273982 0.596315382 -0.745852543 0.252109334 1 0.914777106 0.5689934 259232 "sodium leak channel, non-selective" "GO:0005244,GO:0005261,GO:0005272,GO:0005515,GO:0005886,GO:0016021,GO:0022840,GO:0034220,GO:0034765,GO:0035725,GO:0060075,GO:0070588,GO:0071805" voltage-gated ion channel activity|cation channel activity|sodium channel activity|protein binding|plasma membrane|integral component of membrane|leak channel activity|ion transmembrane transport|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of resting membrane potential|calcium ion transmembrane transport|potassium ion transmembrane transport NAMPT 11028.18466 12301.26634 9755.102988 0.79301616 -0.33457783 0.324519193 1 142.8935192 118.198101 10135 nicotinamide phosphoribosyltransferase "GO:0004514,GO:0005125,GO:0005515,GO:0005829,GO:0007165,GO:0007267,GO:0007623,GO:0008284,GO:0008286,GO:0016607,GO:0030054,GO:0032922,GO:0034356,GO:0042802,GO:0045944,GO:0047280,GO:0051770,GO:0060612,GO:0070062" nicotinate-nucleotide diphosphorylase (carboxylating) activity|cytokine activity|protein binding|cytosol|signal transduction|cell-cell signaling|circadian rhythm|positive regulation of cell population proliferation|insulin receptor signaling pathway|nuclear speck|cell junction|circadian regulation of gene expression|NAD biosynthesis via nicotinamide riboside salvage pathway|identical protein binding|positive regulation of transcription by RNA polymerase II|nicotinamide phosphoribosyltransferase activity|positive regulation of nitric-oxide synthase biosynthetic process|adipose tissue development|extracellular exosome "hsa00760,hsa04621" Nicotinate and nicotinamide metabolism|NOD-like receptor signaling pathway NANOS1 10.09017658 16.23929549 3.941057666 0.242686493 -2.042834281 0.159062261 1 0.204745588 0.051829389 340719 nanos C2HC-type zinc finger 1 "GO:0001558,GO:0001894,GO:0003729,GO:0005515,GO:0005737,GO:0008270,GO:0010608,GO:0010631,GO:0016477,GO:0017148,GO:0030371,GO:0048471,GO:0048477,GO:0098749,GO:1900153" "regulation of cell growth|tissue homeostasis|mRNA binding|protein binding|cytoplasm|zinc ion binding|posttranscriptional regulation of gene expression|epithelial cell migration|cell migration|negative regulation of translation|translation repressor activity|perinuclear region of cytoplasm|oogenesis|cerebellar neuron development|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" NANOS3 11.53838165 14.20938356 8.867379749 0.624050981 -0.680264202 0.643504881 1 0.759129905 0.494142377 342977 nanos C2HC-type zinc finger 3 "GO:0000932,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0006417,GO:0007275,GO:0007281,GO:0007283,GO:0008270,GO:0010494,GO:0017148,GO:0048471,GO:0048477,GO:0051726,GO:1900153,GO:2001234" "P-body|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|regulation of translation|multicellular organism development|germ cell development|spermatogenesis|zinc ion binding|cytoplasmic stress granule|negative regulation of translation|perinuclear region of cytoplasm|oogenesis|regulation of cell cycle|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of apoptotic signaling pathway" NANP 449.2155016 433.3861985 465.0448046 1.07304941 0.101716508 0.812987165 1 5.771622945 6.460016111 140838 N-acetylneuraminic acid phosphatase "GO:0005575,GO:0005829,GO:0005975,GO:0006045,GO:0016311,GO:0046380,GO:0050124" cellular_component|cytosol|carbohydrate metabolic process|N-acetylglucosamine biosynthetic process|dephosphorylation|N-acetylneuraminate biosynthetic process|N-acylneuraminate-9-phosphatase activity hsa00520 Amino sugar and nucleotide sugar metabolism NANS 1093.573978 1039.314912 1147.833045 1.10441314 0.143279958 0.681204082 1 35.49402144 40.88864344 54187 N-acetylneuraminate synthase "GO:0005737,GO:0005829,GO:0006055,GO:0008781,GO:0016051,GO:0047444,GO:0050462,GO:0070062,GO:0070085" cytoplasm|cytosol|CMP-N-acetylneuraminate biosynthetic process|N-acylneuraminate cytidylyltransferase activity|carbohydrate biosynthetic process|N-acylneuraminate-9-phosphate synthase activity|N-acetylneuraminate synthase activity|extracellular exosome|glycosylation hsa00520 Amino sugar and nucleotide sugar metabolism NAP1L1 12520.31368 12230.21942 12810.40794 1.04743893 0.066866132 0.845838571 1 42.94352939 46.91831167 4673 nucleosome assembly protein 1 like 1 "GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0006260,GO:0006334,GO:0008284,GO:0016020,GO:0030154,GO:0042393,GO:0042470,GO:0050769,GO:2000179" chromatin binding|RNA binding|protein binding|nucleus|cytoplasm|DNA replication|nucleosome assembly|positive regulation of cell population proliferation|membrane|cell differentiation|histone binding|melanosome|positive regulation of neurogenesis|positive regulation of neural precursor cell proliferation NAP1L3 13.98669692 13.19442759 14.77896625 1.120091504 0.163616596 0.957372196 1 0.252265463 0.294731958 4675 nucleosome assembly protein 1 like 3 "GO:0003682,GO:0005515,GO:0005634,GO:0006334,GO:0030154,GO:0042393" chromatin binding|protein binding|nucleus|nucleosome assembly|cell differentiation|histone binding NAP1L4 2806.144659 2668.319241 2943.970077 1.103305044 0.141831725 0.656434766 1 38.94552054 44.81971042 4676 nucleosome assembly protein 1 like 4 "GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0006334,GO:0030154,GO:0031491,GO:0042393,GO:0051082" chromatin binding|RNA binding|protein binding|nucleus|cytoplasm|nucleosome assembly|cell differentiation|nucleosome binding|histone binding|unfolded protein binding NAP1L5 58.70686423 73.07682972 44.33689874 0.606716232 -0.720906186 0.37439543 1 1.930664385 1.221823092 266812 nucleosome assembly protein 1 like 5 "GO:0003682,GO:0005515,GO:0005634,GO:0006334,GO:0042393" chromatin binding|protein binding|nucleus|nucleosome assembly|histone binding NAPA 1255.289471 1250.425753 1260.153189 1.007779299 0.011179727 0.97634447 1 36.1470623 37.99744285 8775 NSF attachment protein alpha "GO:0000139,GO:0000149,GO:0005483,GO:0005515,GO:0005774,GO:0005829,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0007420,GO:0010807,GO:0016020,GO:0016082,GO:0019905,GO:0030182,GO:0031201,GO:0032781,GO:0035249,GO:0035494,GO:0044877,GO:0045176,GO:0048208,GO:0061025,GO:0070044,GO:0070062,GO:0098793,GO:0098794,GO:0098978" "Golgi membrane|SNARE binding|soluble NSF attachment protein activity|protein binding|vacuolar membrane|cytosol|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|brain development|regulation of synaptic vesicle priming|membrane|synaptic vesicle priming|syntaxin binding|neuron differentiation|SNARE complex|positive regulation of ATPase activity|synaptic transmission, glutamatergic|SNARE complex disassembly|protein-containing complex binding|apical protein localization|COPII vesicle coating|membrane fusion|synaptobrevin 2-SNAP-25-syntaxin-1a complex|extracellular exosome|presynapse|postsynapse|glutamatergic synapse" hsa04721 Synaptic vesicle cycle NAPB 308.9152833 305.5017465 312.32882 1.022347085 0.031885072 0.953151583 1 3.736437023 3.984482829 63908 NSF attachment protein beta "GO:0005483,GO:0005515,GO:0005774,GO:0006886,GO:0010807,GO:0019905,GO:0031201,GO:0035249,GO:0035494,GO:0045202,GO:0070044,GO:0070062" "soluble NSF attachment protein activity|protein binding|vacuolar membrane|intracellular protein transport|regulation of synaptic vesicle priming|syntaxin binding|SNARE complex|synaptic transmission, glutamatergic|SNARE complex disassembly|synapse|synaptobrevin 2-SNAP-25-syntaxin-1a complex|extracellular exosome" NAPEPLD 100.159477 111.6451565 88.67379749 0.794246703 -0.332340898 0.630941201 1 0.706715825 0.585485531 222236 N-acyl phosphatidylethanolamine phospholipase D "GO:0000139,GO:0001523,GO:0001659,GO:0005635,GO:0005654,GO:0005737,GO:0005769,GO:0005794,GO:0007568,GO:0008270,GO:0009395,GO:0031901,GO:0032052,GO:0035900,GO:0042622,GO:0042802,GO:0043227,GO:0048874,GO:0050729,GO:0070062,GO:0070290,GO:0070291,GO:0070292,GO:0090336,GO:0102200,GO:1903999" Golgi membrane|retinoid metabolic process|temperature homeostasis|nuclear envelope|nucleoplasm|cytoplasm|early endosome|Golgi apparatus|aging|zinc ion binding|phospholipid catabolic process|early endosome membrane|bile acid binding|response to isolation stress|photoreceptor outer segment membrane|identical protein binding|membrane-bounded organelle|host-mediated regulation of intestinal microbiota composition|positive regulation of inflammatory response|extracellular exosome|N-acylphosphatidylethanolamine-specific phospholipase D activity|N-acylethanolamine metabolic process|N-acylphosphatidylethanolamine metabolic process|positive regulation of brown fat cell differentiation|N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity|negative regulation of eating behavior hsa04723 Retrograde endocannabinoid signaling NAPG 1013.820263 941.8791387 1085.761387 1.15276084 0.205093232 0.560565629 1 11.96459885 14.38643828 8774 NSF attachment protein gamma "GO:0005483,GO:0005515,GO:0005739,GO:0005765,GO:0005774,GO:0006886,GO:0006891,GO:0019905,GO:0031201,GO:0045202,GO:0050821,GO:0061025,GO:0065003,GO:0070062" soluble NSF attachment protein activity|protein binding|mitochondrion|lysosomal membrane|vacuolar membrane|intracellular protein transport|intra-Golgi vesicle-mediated transport|syntaxin binding|SNARE complex|synapse|protein stabilization|membrane fusion|protein-containing complex assembly|extracellular exosome NAPRT 445.2393091 498.3433805 392.1352378 0.786877589 -0.345788875 0.41234251 1 12.83138494 10.53165539 93100 nicotinate phosphoribosyltransferase "GO:0004514,GO:0004516,GO:0005515,GO:0005576,GO:0005829,GO:0006979,GO:0034355,GO:0034356,GO:0035578,GO:0043312,GO:0046872,GO:0070062" nicotinate-nucleotide diphosphorylase (carboxylating) activity|nicotinate phosphoribosyltransferase activity|protein binding|extracellular region|cytosol|response to oxidative stress|NAD salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|azurophil granule lumen|neutrophil degranulation|metal ion binding|extracellular exosome hsa00760 Nicotinate and nicotinamide metabolism NARF 523.462426 693.2149264 353.7099255 0.510245686 -0.970736016 0.016856229 0.570200991 11.40639718 6.070769744 26502 nuclear prelamin A recognition factor "GO:0005521,GO:0005638,GO:0005652,GO:0005654,GO:0005730,GO:0031981" lamin binding|lamin filament|nuclear lamina|nucleoplasm|nucleolus|nuclear lumen NARS1 3566.08935 3497.538267 3634.640433 1.039199618 0.055472806 0.862325894 1 65.63096504 71.14161149 4677 asparaginyl-tRNA synthetase 1 "GO:0003676,GO:0004816,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006418,GO:0006421,GO:0016477,GO:0031728,GO:0046983,GO:0070062" nucleic acid binding|asparagine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|tRNA aminoacylation for protein translation|asparaginyl-tRNA aminoacylation|cell migration|CCR3 chemokine receptor binding|protein dimerization activity|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis NARS2 448.7970982 438.4609783 459.1332181 1.047147274 0.066464361 0.87928319 1 8.573938902 9.364920188 79731 "asparaginyl-tRNA synthetase 2, mitochondrial" "GO:0003676,GO:0004816,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006421" nucleic acid binding|asparagine-tRNA ligase activity|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|asparaginyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis NASP 3473.672933 3443.745601 3503.600265 1.017380687 0.024859613 0.938625915 1 52.88464702 56.12146881 4678 nuclear autoantigenic sperm protein "GO:0000082,GO:0000785,GO:0001824,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006335,GO:0006336,GO:0008584,GO:0015031,GO:0032991,GO:0033574,GO:0034080,GO:0042393,GO:0043486" G1/S transition of mitotic cell cycle|chromatin|blastocyst development|protein binding|nucleus|nucleoplasm|cytoplasm|DNA replication|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|male gonad development|protein transport|protein-containing complex|response to testosterone|CENP-A containing nucleosome assembly|histone binding|histone exchange NAT1 96.25083249 80.1815215 112.3201435 1.400823299 0.486274985 0.482855295 1 0.935478277 1.366888197 9 N-acetyltransferase 1 "GO:0004060,GO:0005829,GO:0006805" arylamine N-acetyltransferase activity|cytosol|xenobiotic metabolic process "hsa00232,hsa00983,hsa05204" Caffeine metabolism|Drug metabolism - other enzymes|Chemical carcinogenesis NAT10 2007.229075 2306.994916 1707.463234 0.740124403 -0.434160311 0.178026204 1 29.40879786 22.70376723 55226 N-acetyltransferase 10 "GO:0000049,GO:0000154,GO:0000781,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005697,GO:0005730,GO:0006473,GO:0008080,GO:0010824,GO:0016020,GO:0030496,GO:0032211,GO:0045727,GO:0051391,GO:0070182,GO:0106162,GO:1904812,GO:1990883" "tRNA binding|rRNA modification|chromosome, telomeric region|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|telomerase holoenzyme complex|nucleolus|protein acetylation|N-acetyltransferase activity|regulation of centrosome duplication|membrane|midbody|negative regulation of telomere maintenance via telomerase|positive regulation of translation|tRNA acetylation|DNA polymerase binding|mRNA N-acetyltransferase activity|rRNA acetylation involved in maturation of SSU-rRNA|rRNA cytidine N-acetyltransferase activity" hsa03008 Ribosome biogenesis in eukaryotes NAT14 345.4833897 380.6084881 310.3582912 0.815426615 -0.294373048 0.517463744 1 14.27887201 12.14492153 57106 N-acetyltransferase 14 (putative) "GO:0003677,GO:0005634,GO:0006352,GO:0008080,GO:0016021,GO:0045893" "DNA binding|nucleus|DNA-templated transcription, initiation|N-acetyltransferase activity|integral component of membrane|positive regulation of transcription, DNA-templated" NAT8L 225.2029426 240.5445645 209.8613207 0.872442581 -0.19686791 0.709611396 1 2.011679921 1.830676745 339983 N-acetyltransferase 8 like "GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0008080,GO:0008652,GO:0016021,GO:0017188,GO:0030867,GO:0031966" protein binding|cytoplasm|mitochondrion|mitochondrial matrix|N-acetyltransferase activity|cellular amino acid biosynthetic process|integral component of membrane|aspartate N-acetyltransferase activity|rough endoplasmic reticulum membrane|mitochondrial membrane hsa00250 "Alanine, aspartate and glutamate metabolism" NAT9 1151.134996 1067.733679 1234.536314 1.156221199 0.209417429 0.543761614 1 20.11042919 24.25371091 26151 N-acetyltransferase 9 (putative) "GO:0005515,GO:0006473,GO:0008080,GO:0032991" protein binding|protein acetylation|N-acetyltransferase activity|protein-containing complex NATD1 495.1666305 409.0272553 581.3060058 1.421191371 0.507100834 0.215963291 1 4.201133141 6.227804013 256302 N-acetyltransferase domain containing 1 GO:0005515 protein binding NAV1 1440.428623 1446.312255 1434.54499 0.991863953 -0.011785845 0.974081712 1 5.206896036 5.386999599 89796 neuron navigator 1 "GO:0001578,GO:0001764,GO:0005737,GO:0005874,GO:0007399,GO:0015630,GO:0043194" microtubule bundle formation|neuron migration|cytoplasm|microtubule|nervous system development|microtubule cytoskeleton|axon initial segment NAV2 1953.737776 1613.77999 2293.695562 1.421318629 0.507230011 0.116499428 1 3.628996688 5.380144619 89797 neuron navigator 2 "GO:0005515,GO:0005524,GO:0005654,GO:0007399,GO:0022008,GO:0032508,GO:0043138" protein binding|ATP binding|nucleoplasm|nervous system development|neurogenesis|DNA duplex unwinding|3'-5' DNA helicase activity NAV3 662.9070325 695.2448383 630.5692266 0.906974337 -0.140866364 0.714908717 1 1.784587623 1.688296831 89795 neuron navigator 3 "GO:0005524,GO:0005640,GO:0007026,GO:0007399,GO:0008017,GO:0016887,GO:0022008,GO:0030336,GO:0031116,GO:0032703,GO:1990752" ATP binding|nuclear outer membrane|negative regulation of microtubule depolymerization|nervous system development|microtubule binding|ATPase activity|neurogenesis|negative regulation of cell migration|positive regulation of microtubule polymerization|negative regulation of interleukin-2 production|microtubule end NAXD 773.9934927 812.9797307 735.0072547 0.904090504 -0.145460893 0.696105888 1 14.82165419 13.9773395 55739 NAD(P)HX dehydratase "GO:0005515,GO:0005524,GO:0005575,GO:0005759,GO:0008150,GO:0034356,GO:0047453,GO:0052855,GO:0110051" protein binding|ATP binding|cellular_component|mitochondrial matrix|biological_process|NAD biosynthesis via nicotinamide riboside salvage pathway|ATP-dependent NAD(P)H-hydrate dehydratase activity|ADP-dependent NAD(P)H-hydrate dehydratase activity|metabolite repair NAXE 1271.97414 1313.353023 1230.595256 0.936987417 -0.093898422 0.783506562 1 15.75105313 15.39427657 128240 NAD(P)HX epimerase "GO:0000166,GO:0002040,GO:0005515,GO:0005576,GO:0005615,GO:0005739,GO:0005759,GO:0006869,GO:0010874,GO:0016020,GO:0016525,GO:0031580,GO:0034356,GO:0046496,GO:0046872,GO:0052856,GO:0052857,GO:0070062" nucleotide binding|sprouting angiogenesis|protein binding|extracellular region|extracellular space|mitochondrion|mitochondrial matrix|lipid transport|regulation of cholesterol efflux|membrane|negative regulation of angiogenesis|membrane raft distribution|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinamide nucleotide metabolic process|metal ion binding|NADHX epimerase activity|NADPHX epimerase activity|extracellular exosome NBAS 954.3508208 884.0266485 1024.674993 1.159099666 0.213004623 0.549775368 1 5.790588604 7.000989428 51594 NBAS subunit of NRZ tethering complex "GO:0000149,GO:0000956,GO:0005783,GO:0005789,GO:0005829,GO:0006890,GO:0015031,GO:0016020,GO:0070939,GO:2000623" "SNARE binding|nuclear-transcribed mRNA catabolic process|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|membrane|Dsl1/NZR complex|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" NBDY 956.5128609 1099.197314 813.8284081 0.740384277 -0.433653837 0.222190915 1 23.74007088 18.3339114 550643 negative regulator of P-body association "GO:0000932,GO:0000956,GO:0005515,GO:0006397,GO:0010607" P-body|nuclear-transcribed mRNA catabolic process|protein binding|mRNA processing|negative regulation of cytoplasmic mRNA processing body assembly NBEA 513.8191065 505.4480723 522.1901408 1.033123222 0.047012336 0.912562186 1 1.918258655 2.067165363 26960 neurobeachin "GO:0005802,GO:0005829,GO:0005886,GO:0008104,GO:0012505,GO:0016020,GO:0019901" trans-Golgi network|cytosol|plasma membrane|protein localization|endomembrane system|membrane|protein kinase binding NBEAL1 905.0133711 878.9518686 931.0748736 1.059301319 0.083113023 0.81928574 1 2.4215749 2.675674928 65065 neurobeachin like 1 "GO:0005829,GO:0008104,GO:0016020,GO:0019901" cytosol|protein localization|membrane|protein kinase binding NBEAL2 697.8663519 727.7234293 668.0092744 0.917943888 -0.123522127 0.74636901 1 3.55039249 3.399448222 23218 neurobeachin like 2 "GO:0005515,GO:0005783,GO:0005829,GO:0005886,GO:0008104,GO:0016020,GO:0019901,GO:0030220,GO:0043312,GO:0070821,GO:0101003" protein binding|endoplasmic reticulum|cytosol|plasma membrane|protein localization|membrane|protein kinase binding|platelet formation|neutrophil degranulation|tertiary granule membrane|ficolin-1-rich granule membrane NBL1 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.082378108 0.083412923 4681 "NBL1, DAN family BMP antagonist" "GO:0005515,GO:0005615,GO:0007165,GO:0007399,GO:0009887,GO:0016015,GO:0030514,GO:0035582,GO:0036122,GO:0038098,GO:0042802,GO:0045666,GO:0048018,GO:0048263,GO:0048812,GO:0090027" protein binding|extracellular space|signal transduction|nervous system development|animal organ morphogenesis|morphogen activity|negative regulation of BMP signaling pathway|sequestering of BMP in extracellular matrix|BMP binding|sequestering of BMP from receptor via BMP binding|identical protein binding|positive regulation of neuron differentiation|receptor ligand activity|determination of dorsal identity|neuron projection morphogenesis|negative regulation of monocyte chemotaxis hsa04350 TGF-beta signaling pathway NBN 1865.048886 1983.223962 1746.873811 0.880825284 -0.183072212 0.572563514 1 19.56814675 17.97858051 4683 nibrin "GO:0000077,GO:0000723,GO:0000724,GO:0000729,GO:0000781,GO:0001832,GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005730,GO:0005829,GO:0006260,GO:0006302,GO:0006303,GO:0007050,GO:0007095,GO:0008134,GO:0008283,GO:0016032,GO:0016605,GO:0030174,GO:0030330,GO:0030870,GO:0031860,GO:0031954,GO:0032206,GO:0032508,GO:0033674,GO:0035861,GO:0042405,GO:0042770,GO:0045190,GO:0047485,GO:0050885,GO:0051321,GO:0090656,GO:0090737,GO:0097193,GO:1901796,GO:1904354" "DNA damage checkpoint|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|chromosome, telomeric region|blastocyst growth|damaged DNA binding|protein binding|nucleus|nucleoplasm|replication fork|nucleolus|cytosol|DNA replication|double-strand break repair|double-strand break repair via nonhomologous end joining|cell cycle arrest|mitotic G2 DNA damage checkpoint|transcription factor binding|cell population proliferation|viral process|PML body|regulation of DNA-dependent DNA replication initiation|DNA damage response, signal transduction by p53 class mediator|Mre11 complex|telomeric 3' overhang formation|positive regulation of protein autophosphorylation|positive regulation of telomere maintenance|DNA duplex unwinding|positive regulation of kinase activity|site of double-strand break|nuclear inclusion body|signal transduction in response to DNA damage|isotype switching|protein N-terminus binding|neuromuscular process controlling balance|meiotic cell cycle|t-circle formation|telomere maintenance via telomere trimming|intrinsic apoptotic signaling pathway|regulation of signal transduction by p53 class mediator|negative regulation of telomere capping" "hsa03440,hsa04218" Homologous recombination|Cellular senescence NBPF1 328.5760343 302.4568786 354.69519 1.172713253 0.229850295 0.62020285 1 2.572787016 3.147107648 55672 NBPF member 1 "GO:0005515,GO:0005737" protein binding|cytoplasm NBPF10 196.620872 172.5425146 220.6992293 1.279100573 0.355129705 0.515275693 1 0.670040613 0.893967541 100132406 NBPF member 10 "GO:0003723,GO:0005737" RNA binding|cytoplasm NBPF11 268.6436516 246.6343003 290.6530029 1.178477619 0.236924359 0.632362763 1 2.055480868 2.526682704 200030 NBPF member 11 GO:0005737 cytoplasm NBPF12 366.0875894 341.0252054 391.1499734 1.14698259 0.197843493 0.659893095 1 2.330237937 2.787873245 149013 NBPF member 12 GO:0005737 cytoplasm NBPF14 545.2085126 563.3005624 527.1164629 0.935764134 -0.095783161 0.814458534 1 2.830276417 2.762556556 25832 NBPF member 14 GO:0005737 cytoplasm NBPF15 1213.357834 1044.389691 1382.325976 1.32357298 0.404437745 0.236405181 1 8.936417213 12.33750265 284565 NBPF member 15 GO:0005737 cytoplasm NBPF19 568.7779082 591.7193296 545.8364868 0.922458435 -0.116444188 0.771916461 1 2.149666206 2.068396363 101060226 NBPF member 19 GO:0005737 cytoplasm NBPF20 243.8635834 236.4847406 251.2424262 1.062404388 0.087333011 0.870299831 1 0.649166279 0.719385596 100288142 NBPF member 20 GO:0005737 cytoplasm NBPF26 132.8837652 92.36099312 173.4065373 1.877486712 0.908802697 0.141688739 1 0.825292603 1.616221033 101060684 NBPF member 26 GO:0005737 cytoplasm NBPF3 196.6654093 175.5873825 217.7434361 1.240085893 0.310440051 0.570504049 1 1.715778794 2.219366328 84224 NBPF member 3 GO:0005737 cytoplasm NBPF8 607.3219866 599.8389773 614.8049959 1.02495006 0.035553617 0.931691488 1 4.182231291 4.471226618 728841 NBPF member 8 GO:0005737 cytoplasm NBPF9 1003.142936 986.5372013 1019.748671 1.033664691 0.047768268 0.894813605 1 5.747024264 6.196388537 400818 NBPF member 9 GO:0005737 cytoplasm NBR1 3984.702517 3556.405713 4412.999322 1.240859361 0.31133961 0.328769991 1 27.73628012 35.89935999 4077 NBR1 autophagy cargo receptor "GO:0000407,GO:0005515,GO:0005654,GO:0005739,GO:0005758,GO:0005764,GO:0005770,GO:0005776,GO:0005829,GO:0008270,GO:0016020,GO:0016236,GO:0016604,GO:0030500,GO:0031430,GO:0032872,GO:0043130,GO:0043231,GO:0043235,GO:0045668,GO:0051019" phagophore assembly site|protein binding|nucleoplasm|mitochondrion|mitochondrial intermembrane space|lysosome|late endosome|autophagosome|cytosol|zinc ion binding|membrane|macroautophagy|nuclear body|regulation of bone mineralization|M band|regulation of stress-activated MAPK cascade|ubiquitin binding|intracellular membrane-bounded organelle|receptor complex|negative regulation of osteoblast differentiation|mitogen-activated protein kinase binding hsa04137 Mitophagy - animal NCALD 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.012321174 0.0499038 83988 neurocalcin delta "GO:0003779,GO:0005509,GO:0005515,GO:0005829,GO:0015631,GO:0016192,GO:0030130,GO:0030276" actin binding|calcium ion binding|protein binding|cytosol|tubulin binding|vesicle-mediated transport|clathrin coat of trans-Golgi network vesicle|clathrin binding hsa04740 Olfactory transduction NCAM1 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.018459638 0.018691524 4684 neural cell adhesion molecule 1 "GO:0000139,GO:0000165,GO:0001618,GO:0005515,GO:0005829,GO:0005886,GO:0007155,GO:0007411,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031225,GO:0043005,GO:0046718,GO:0060333,GO:0062023,GO:0071679,GO:2001260" Golgi membrane|MAPK cascade|virus receptor activity|protein binding|cytosol|plasma membrane|cell adhesion|axon guidance|external side of plasma membrane|cell surface|membrane|integral component of membrane|anchored component of membrane|neuron projection|viral entry into host cell|interferon-gamma-mediated signaling pathway|collagen-containing extracellular matrix|commissural neuron axon guidance|regulation of semaphorin-plexin signaling pathway "hsa04514,hsa05020" Cell adhesion molecules|Prion disease NCAPD2 6603.983193 5944.597107 7263.369279 1.221843827 0.289059895 0.375824093 1 62.39852273 79.52541365 9918 non-SMC condensin I complex subunit D2 "GO:0000228,GO:0000779,GO:0000793,GO:0000796,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007076,GO:0010032,GO:0016020,GO:0042393,GO:0051301,GO:0051304" "nuclear chromosome|condensed chromosome, centromeric region|condensed chromosome|condensin complex|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mitotic chromosome condensation|meiotic chromosome condensation|membrane|histone binding|cell division|chromosome separation" NCAPD3 2992.421738 2638.885518 3345.957959 1.267943583 0.342490554 0.281883938 1 17.05810364 22.56039029 23310 non-SMC condensin II complex subunit D3 "GO:0000779,GO:0000796,GO:0003682,GO:0005515,GO:0005654,GO:0005721,GO:0007076,GO:0010032,GO:0016020,GO:0035064,GO:0042393,GO:0051301,GO:0051304" "condensed chromosome, centromeric region|condensin complex|chromatin binding|protein binding|nucleoplasm|pericentric heterochromatin|mitotic chromosome condensation|meiotic chromosome condensation|membrane|methylated histone binding|histone binding|cell division|chromosome separation" NCAPG 1575.768868 1437.177651 1714.360085 1.192865811 0.254431759 0.440404316 1 18.83746842 23.43851316 64151 non-SMC condensin I complex subunit G "GO:0000779,GO:0000793,GO:0000796,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007076,GO:0016020,GO:0051301" "condensed chromosome, centromeric region|condensed chromosome|condensin complex|protein binding|nucleus|cytoplasm|cytosol|mitotic chromosome condensation|membrane|cell division" NCAPG2 2911.600364 2636.855606 3186.345123 1.208388171 0.273083967 0.390956314 1 22.35103501 28.17215271 54892 non-SMC condensin II complex subunit G2 "GO:0000070,GO:0000796,GO:0001833,GO:0005515,GO:0005634,GO:0005654,GO:0006366,GO:0010468,GO:0016020,GO:0016607,GO:0030218,GO:0030261,GO:0035064,GO:0043425,GO:0045647,GO:0051301,GO:0061098,GO:0140416,GO:2000273" mitotic sister chromatid segregation|condensin complex|inner cell mass cell proliferation|protein binding|nucleus|nucleoplasm|transcription by RNA polymerase II|regulation of gene expression|membrane|nuclear speck|erythrocyte differentiation|chromosome condensation|methylated histone binding|bHLH transcription factor binding|negative regulation of erythrocyte differentiation|cell division|positive regulation of protein tyrosine kinase activity|transcription regulator inhibitor activity|positive regulation of signaling receptor activity NCAPH 1116.641339 999.7316288 1233.55105 1.233882188 0.303204651 0.381082926 1 18.15449271 23.3654281 23397 non-SMC condensin I complex subunit H "GO:0000796,GO:0003682,GO:0005515,GO:0005654,GO:0005829,GO:0007076,GO:0016020,GO:0044547,GO:0051301,GO:0072587,GO:2000373" "condensin complex|chromatin binding|protein binding|nucleoplasm|cytosol|mitotic chromosome condensation|membrane|DNA topoisomerase binding|cell division|DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity" NCAPH2 1171.388341 936.8043588 1405.972322 1.500817443 0.585748501 0.088425649 1 22.6147931 35.40270263 29781 non-SMC condensin II complex subunit H2 "GO:0000793,GO:0000796,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0007076,GO:0010032,GO:0016020,GO:0030054,GO:0033077,GO:0045171,GO:0051306,GO:0051309" condensed chromosome|condensin complex|chromatin binding|protein binding|nucleus|nucleoplasm|mitotic chromosome condensation|meiotic chromosome condensation|membrane|cell junction|T cell differentiation in thymus|intercellular bridge|mitotic sister chromatid separation|female meiosis chromosome separation NCBP1 1706.028644 1855.33951 1556.717778 0.839047392 -0.253175793 0.438649929 1 18.85739533 16.50380667 4686 nuclear cap binding protein subunit 1 "GO:0000184,GO:0000245,GO:0000339,GO:0000340,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0005845,GO:0005846,GO:0006366,GO:0006368,GO:0006369,GO:0006370,GO:0006401,GO:0006405,GO:0006406,GO:0006446,GO:0008334,GO:0008380,GO:0008543,GO:0016070,GO:0030307,GO:0031047,GO:0031124,GO:0031442,GO:0034518,GO:0042795,GO:0045292,GO:0048026,GO:0050684,GO:0051168,GO:0098789,GO:1900363,GO:1905216,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|spliceosomal complex assembly|RNA cap binding|RNA 7-methylguanosine cap binding|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|mRNA cap binding complex|nuclear cap binding complex|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|termination of RNA polymerase II transcription|7-methylguanosine mRNA capping|RNA catabolic process|RNA export from nucleus|mRNA export from nucleus|regulation of translational initiation|histone mRNA metabolic process|RNA splicing|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of cell growth|gene silencing by RNA|mRNA 3'-end processing|positive regulation of mRNA 3'-end processing|RNA cap binding complex|snRNA transcription by RNA polymerase II|mRNA cis splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|regulation of mRNA processing|nuclear export|pre-mRNA cleavage required for polyadenylation|regulation of mRNA polyadenylation|positive regulation of RNA binding|ribonucleoprotein complex" "hsa03013,hsa03015,hsa03040,hsa05014" RNA transport|mRNA surveillance pathway|Spliceosome|Amyotrophic lateral sclerosis NCBP2 2018.816199 2088.779383 1948.853016 0.933010461 -0.100034837 0.757074604 1 19.35052259 18.83194344 22916 nuclear cap binding protein subunit 2 "GO:0000184,GO:0000339,GO:0000340,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005845,GO:0005846,GO:0006366,GO:0006368,GO:0006369,GO:0006370,GO:0006405,GO:0006406,GO:0006408,GO:0006446,GO:0008334,GO:0008380,GO:0008543,GO:0016070,GO:0017069,GO:0031047,GO:0031124,GO:0031442,GO:0034518,GO:0042795,GO:0045292,GO:0046833,GO:0051168,GO:0098789,GO:1900363" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA cap binding|RNA 7-methylguanosine cap binding|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA cap binding complex|nuclear cap binding complex|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|termination of RNA polymerase II transcription|7-methylguanosine mRNA capping|RNA export from nucleus|mRNA export from nucleus|snRNA export from nucleus|regulation of translational initiation|histone mRNA metabolic process|RNA splicing|fibroblast growth factor receptor signaling pathway|RNA metabolic process|snRNA binding|gene silencing by RNA|mRNA 3'-end processing|positive regulation of mRNA 3'-end processing|RNA cap binding complex|snRNA transcription by RNA polymerase II|mRNA cis splicing, via spliceosome|positive regulation of RNA export from nucleus|nuclear export|pre-mRNA cleavage required for polyadenylation|regulation of mRNA polyadenylation" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome NCBP2AS2 285.2540915 304.4867905 266.0213925 0.873671373 -0.194837375 0.689419446 1 17.72549629 16.15334391 152217 NCBP2 antisense 2 (head to head) GO:0005515 protein binding NCBP3 1523.678023 1513.299349 1534.056697 1.013716617 0.019654406 0.954745121 1 5.939037072 6.279839317 55421 nuclear cap binding subunit 3 "GO:0000339,GO:0000340,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0006370,GO:0016607,GO:0034518,GO:0051028,GO:0051607" RNA cap binding|RNA 7-methylguanosine cap binding|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|7-methylguanosine mRNA capping|nuclear speck|RNA cap binding complex|mRNA transport|defense response to virus NCDN 738.2391824 827.1891142 649.2892505 0.784934472 -0.349355875 0.349856037 1 12.22831596 10.01188803 23154 neurochondrin "GO:0005515,GO:0005634,GO:0005829,GO:0010008,GO:0016020,GO:0030424,GO:0030425,GO:0031175,GO:0043025,GO:0043204,GO:0045453,GO:0048168,GO:0098794" protein binding|nucleus|cytosol|endosome membrane|membrane|axon|dendrite|neuron projection development|neuronal cell body|perikaryon|bone resorption|regulation of neuronal synaptic plasticity|postsynapse NCEH1 1564.575899 1581.301399 1547.850398 0.978845905 -0.030846334 0.927445641 1 17.56301258 17.9320223 57552 neutral cholesterol ester hydrolase 1 "GO:0004771,GO:0005789,GO:0005886,GO:0016020,GO:0016021,GO:0016042,GO:0016787,GO:0034383,GO:0046485" sterol esterase activity|endoplasmic reticulum membrane|plasma membrane|membrane|integral component of membrane|lipid catabolic process|hydrolase activity|low-density lipoprotein particle clearance|ether lipid metabolic process "hsa04927,hsa04934,hsa04976,hsa04979" Cortisol synthesis and secretion|Cushing syndrome|Bile secretion|Cholesterol metabolism NCF2 5.059934066 9.134603715 0.985264417 0.107860663 -3.212759283 0.136251646 1 0.185425031 0.020861589 4688 neutrophil cytosolic factor 2 "GO:0001669,GO:0002479,GO:0005515,GO:0005829,GO:0006801,GO:0006909,GO:0006968,GO:0008022,GO:0009055,GO:0016020,GO:0016175,GO:0016176,GO:0022900,GO:0032010,GO:0034599,GO:0042554,GO:0043020,GO:0045087,GO:0045454,GO:0045730,GO:0048010,GO:0050790,GO:0055114" "acrosomal vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|cytosol|superoxide metabolic process|phagocytosis|cellular defense response|protein C-terminus binding|electron transfer activity|membrane|superoxide-generating NAD(P)H oxidase activity|superoxide-generating NADPH oxidase activator activity|electron transport chain|phagolysosome|cellular response to oxidative stress|superoxide anion generation|NADPH oxidase complex|innate immune response|cell redox homeostasis|respiratory burst|vascular endothelial growth factor receptor signaling pathway|regulation of catalytic activity|oxidation-reduction process" "hsa04145,hsa04380,hsa04670,hsa05020,hsa05140,hsa05418" Phagosome|Osteoclast differentiation|Leukocyte transendothelial migration|Prion disease|Leishmaniasis|Fluid shear stress and atherosclerosis NCK1 387.847038 414.1020351 361.5920409 0.873195518 -0.19562337 0.657908855 1 4.40050508 4.008020684 4690 NCK adaptor protein 1 "GO:0000164,GO:0004860,GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005840,GO:0005886,GO:0005911,GO:0006469,GO:0006930,GO:0007015,GO:0007172,GO:0008093,GO:0010976,GO:0012506,GO:0019904,GO:0030032,GO:0030159,GO:0030334,GO:0030674,GO:0030838,GO:0030971,GO:0033137,GO:0035591,GO:0036493,GO:0038096,GO:0042102,GO:0042110,GO:0045296,GO:0045944,GO:0046627,GO:0046875,GO:0048010,GO:0048013,GO:0050852,GO:0051707,GO:0060548,GO:0070262,GO:0071074,GO:1902237,GO:1903676,GO:1903679,GO:1903898,GO:1903912,GO:1990441" "protein phosphatase type 1 complex|protein kinase inhibitor activity|signaling receptor binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|ribosome|plasma membrane|cell-cell junction|negative regulation of protein kinase activity|substrate-dependent cell migration, cell extension|actin filament organization|signal complex assembly|cytoskeletal anchor activity|positive regulation of neuron projection development|vesicle membrane|protein domain specific binding|lamellipodium assembly|signaling receptor complex adaptor activity|regulation of cell migration|protein-macromolecule adaptor activity|positive regulation of actin filament polymerization|receptor tyrosine kinase binding|negative regulation of peptidyl-serine phosphorylation|signaling adaptor activity|positive regulation of translation in response to endoplasmic reticulum stress|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of T cell proliferation|T cell activation|cadherin binding|positive regulation of transcription by RNA polymerase II|negative regulation of insulin receptor signaling pathway|ephrin receptor binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|T cell receptor signaling pathway|response to other organism|negative regulation of cell death|peptidyl-serine dephosphorylation|eukaryotic initiation factor eIF2 binding|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of cap-dependent translational initiation|positive regulation of cap-independent translational initiation|negative regulation of PERK-mediated unfolded protein response|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" "hsa04012,hsa04360,hsa04660,hsa05130" ErbB signaling pathway|Axon guidance|T cell receptor signaling pathway|Pathogenic Escherichia coli infection NCK2 701.3026532 693.2149264 709.3903799 1.023333966 0.033277047 0.933667056 1 8.673144888 9.257845323 8440 NCK adaptor protein 2 "GO:0001771,GO:0001784,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0007015,GO:0007165,GO:0007172,GO:0007173,GO:0007176,GO:0008093,GO:0008285,GO:0012506,GO:0014069,GO:0016477,GO:0030032,GO:0030159,GO:0030838,GO:0033137,GO:0035591,GO:0036493,GO:0042102,GO:0042110,GO:0044877,GO:0045944,GO:0048010,GO:0048013,GO:0060996,GO:0097110,GO:1902237,GO:1903898,GO:1903912,GO:1990441" immunological synapse formation|phosphotyrosine residue binding|protein binding|cytoplasm|endoplasmic reticulum|cytosol|actin filament organization|signal transduction|signal complex assembly|epidermal growth factor receptor signaling pathway|regulation of epidermal growth factor-activated receptor activity|cytoskeletal anchor activity|negative regulation of cell population proliferation|vesicle membrane|postsynaptic density|cell migration|lamellipodium assembly|signaling receptor complex adaptor activity|positive regulation of actin filament polymerization|negative regulation of peptidyl-serine phosphorylation|signaling adaptor activity|positive regulation of translation in response to endoplasmic reticulum stress|positive regulation of T cell proliferation|T cell activation|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|dendritic spine development|scaffold protein binding|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of PERK-mediated unfolded protein response|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress "hsa04012,hsa04360,hsa04660,hsa05130" ErbB signaling pathway|Axon guidance|T cell receptor signaling pathway|Pathogenic Escherichia coli infection NCKAP1 5153.750423 4636.318864 5671.181982 1.223207926 0.29066966 0.366185559 1 11.60316225 14.80446036 10787 NCK associated protein 1 "GO:0000902,GO:0001726,GO:0005515,GO:0005829,GO:0005925,GO:0006915,GO:0007417,GO:0010592,GO:0016021,GO:0016032,GO:0016477,GO:0016601,GO:0030027,GO:0030031,GO:0030838,GO:0030866,GO:0031209,GO:0031258,GO:0031267,GO:0031941,GO:0038096,GO:0048010,GO:0048812,GO:0070062,GO:2000601" cell morphogenesis|ruffle|protein binding|cytosol|focal adhesion|apoptotic process|central nervous system development|positive regulation of lamellipodium assembly|integral component of membrane|viral process|cell migration|Rac protein signal transduction|lamellipodium|cell projection assembly|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|SCAR complex|lamellipodium membrane|small GTPase binding|filamentous actin|Fc-gamma receptor signaling pathway involved in phagocytosis|vascular endothelial growth factor receptor signaling pathway|neuron projection morphogenesis|extracellular exosome|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04810,hsa05130,hsa05132" Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection NCKAP5 33.07786523 38.5683268 27.58740366 0.715286505 -0.483406873 0.629772105 1 0.158551111 0.11829469 344148 NCK associated protein 5 "GO:0001578,GO:0005575,GO:0007019,GO:0008150,GO:0035371" microtubule bundle formation|cellular_component|microtubule depolymerization|biological_process|microtubule plus-end NCKAP5L 937.4825595 875.9070007 999.0581184 1.140598394 0.189790907 0.595586183 1 8.230352425 9.791903339 57701 NCK associated protein 5 like "GO:0001578,GO:0005515,GO:0005737,GO:0005813,GO:0007019,GO:0035371" microtubule bundle formation|protein binding|cytoplasm|centrosome|microtubule depolymerization|microtubule plus-end NCKIPSD 1070.178527 1258.545401 881.8116528 0.70065939 -0.513214814 0.140943075 1 15.24901547 11.14460503 51517 NCK interacting protein with SH3 domain "GO:0005515,GO:0005829,GO:0005882,GO:0007010,GO:0008092,GO:0008180,GO:0010976,GO:0017124,GO:0038096" protein binding|cytosol|intermediate filament|cytoskeleton organization|cytoskeletal protein binding|COP9 signalosome|positive regulation of neuron projection development|SH3 domain binding|Fc-gamma receptor signaling pathway involved in phagocytosis NCL 9346.917281 10320.07229 8373.762276 0.81140539 -0.301505209 0.367684953 1 133.1996061 112.734478 4691 nucleolin "GO:0001525,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005694,GO:0005730,GO:0005938,GO:0008022,GO:0016020,GO:0017148,GO:0036464,GO:0042162,GO:0042802,GO:0044547,GO:0048026,GO:0048027,GO:0070062,GO:1901838,GO:1990904" "angiogenesis|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|chromosome|nucleolus|cell cortex|protein C-terminus binding|membrane|negative regulation of translation|cytoplasmic ribonucleoprotein granule|telomeric DNA binding|identical protein binding|DNA topoisomerase binding|positive regulation of mRNA splicing, via spliceosome|mRNA 5'-UTR binding|extracellular exosome|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|ribonucleoprotein complex" hsa05130 Pathogenic Escherichia coli infection NCLN 1597.900699 1704.111071 1491.690327 0.875348064 -0.192071306 0.559972068 1 23.45304728 21.41391056 56926 nicalin "GO:0005515,GO:0005789,GO:0009966,GO:0016020,GO:0016021,GO:0032991,GO:0043254,GO:0050821,GO:0061635" protein binding|endoplasmic reticulum membrane|regulation of signal transduction|membrane|integral component of membrane|protein-containing complex|regulation of protein-containing complex assembly|protein stabilization|regulation of protein complex stability NCOA1 537.4748551 573.4501221 501.499588 0.874530441 -0.193419492 0.632077284 1 3.69506688 3.370646161 8648 nuclear receptor coactivator 1 "GO:0000435,GO:0000785,GO:0000977,GO:0002155,GO:0003682,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0007595,GO:0008584,GO:0015721,GO:0016922,GO:0017162,GO:0019216,GO:0019899,GO:0021549,GO:0021766,GO:0021854,GO:0021987,GO:0030331,GO:0030374,GO:0032355,GO:0032526,GO:0032570,GO:0032870,GO:0032991,GO:0033142,GO:0035257,GO:0043005,GO:0043065,GO:0043967,GO:0044849,GO:0044877,GO:0045666,GO:0045893,GO:0045925,GO:0045944,GO:0046965,GO:0046983,GO:0047485,GO:0060179,GO:0060713,GO:1904017,GO:2001038" "positive regulation of transcription from RNA polymerase II promoter by galactose|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|regulation of thyroid hormone mediated signaling pathway|chromatin binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|lactation|male gonad development|bile acid and bile salt transport|nuclear receptor binding|aryl hydrocarbon receptor binding|regulation of lipid metabolic process|enzyme binding|cerebellum development|hippocampus development|hypothalamus development|cerebral cortex development|estrogen receptor binding|nuclear receptor coactivator activity|response to estradiol|response to retinoic acid|response to progesterone|cellular response to hormone stimulus|protein-containing complex|progesterone receptor binding|nuclear hormone receptor binding|neuron projection|positive regulation of apoptotic process|histone H4 acetylation|estrous cycle|protein-containing complex binding|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of female receptivity|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|protein dimerization activity|protein N-terminus binding|male mating behavior|labyrinthine layer morphogenesis|cellular response to Thyroglobulin triiodothyronine|regulation of cellular response to drug" "hsa04915,hsa04919,hsa05200,hsa05224" Estrogen signaling pathway|Thyroid hormone signaling pathway|Pathways in cancer|Breast cancer NCOA2 1985.484718 1864.474114 2106.495323 1.129806688 0.176075945 0.585506735 1 5.210165328 6.140045299 10499 nuclear receptor coactivator 2 "GO:0000122,GO:0000785,GO:0000978,GO:0001162,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0010906,GO:0015721,GO:0016604,GO:0016922,GO:0017162,GO:0019216,GO:0019904,GO:0030374,GO:0032570,GO:0032870,GO:0032922,GO:0032991,GO:0035257,GO:0045475,GO:0045944,GO:0046983,GO:1904017" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of glucose metabolic process|bile acid and bile salt transport|nuclear body|nuclear receptor binding|aryl hydrocarbon receptor binding|regulation of lipid metabolic process|protein domain specific binding|nuclear receptor coactivator activity|response to progesterone|cellular response to hormone stimulus|circadian regulation of gene expression|protein-containing complex|nuclear hormone receptor binding|locomotor rhythm|positive regulation of transcription by RNA polymerase II|protein dimerization activity|cellular response to Thyroglobulin triiodothyronine" "hsa04915,hsa04919" Estrogen signaling pathway|Thyroid hormone signaling pathway NCOA3 2782.954572 2564.793732 3001.115413 1.170119599 0.226655996 0.476755667 1 16.27995419 19.87006839 8202 nuclear receptor coactivator 3 "GO:0000785,GO:0000993,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016573,GO:0016922,GO:0030374,GO:0032870,GO:0032991,GO:0035257,GO:0035624,GO:0043697,GO:0045618,GO:0045944,GO:0046966,GO:0046983,GO:0047485,GO:0070062,GO:0071392,GO:0097718,GO:1902459,GO:2000035" chromatin|RNA polymerase II complex binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|histone acetylation|nuclear receptor binding|nuclear receptor coactivator activity|cellular response to hormone stimulus|protein-containing complex|nuclear hormone receptor binding|receptor transactivation|cell dedifferentiation|positive regulation of keratinocyte differentiation|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|protein dimerization activity|protein N-terminus binding|extracellular exosome|cellular response to estradiol stimulus|disordered domain specific binding|positive regulation of stem cell population maintenance|regulation of stem cell division "hsa01522,hsa04915,hsa04919,hsa05200,hsa05224" Endocrine resistance|Estrogen signaling pathway|Thyroid hormone signaling pathway|Pathways in cancer|Breast cancer NCOA4 3869.209091 3844.653208 3893.764974 1.012774043 0.018312335 0.955001768 1 44.52735465 47.0387082 8031 nuclear receptor coactivator 4 "GO:0003713,GO:0005634,GO:0006622,GO:0006879,GO:0008584,GO:0009725,GO:0030520,GO:0044754,GO:0045893,GO:0071391,GO:0071394" "transcription coactivator activity|nucleus|protein targeting to lysosome|cellular iron ion homeostasis|male gonad development|response to hormone|intracellular estrogen receptor signaling pathway|autolysosome|positive regulation of transcription, DNA-templated|cellular response to estrogen stimulus|cellular response to testosterone stimulus" "hsa04216,hsa05200,hsa05216" Ferroptosis|Pathways in cancer|Thyroid cancer NCOA5 1643.295607 1911.162088 1375.429125 0.71968209 -0.47456834 0.148231299 1 29.81016865 22.37798908 57727 nuclear receptor coactivator 5 "GO:0000122,GO:0003682,GO:0003714,GO:0003723,GO:0005515,GO:0005615,GO:0005654,GO:0015629,GO:0042593,GO:0046627" negative regulation of transcription by RNA polymerase II|chromatin binding|transcription corepressor activity|RNA binding|protein binding|extracellular space|nucleoplasm|actin cytoskeleton|glucose homeostasis|negative regulation of insulin receptor signaling pathway NCOA6 3143.396315 3126.064383 3160.728248 1.01108866 0.01590951 0.961172453 1 16.37948819 17.27450043 23054 nuclear receptor coactivator 6 "GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006352,GO:0006974,GO:0007420,GO:0007507,GO:0009725,GO:0019216,GO:0019899,GO:0030099,GO:0030331,GO:0030374,GO:0035097,GO:0043231,GO:0045893,GO:0045944,GO:0046965,GO:0046966,GO:0051427" "chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|DNA-templated transcription, initiation|cellular response to DNA damage stimulus|brain development|heart development|response to hormone|regulation of lipid metabolic process|enzyme binding|myeloid cell differentiation|estrogen receptor binding|nuclear receptor coactivator activity|histone methyltransferase complex|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|thyroid hormone receptor binding|hormone receptor binding" NCOA7 466.8666296 360.3093688 573.4238904 1.591476493 0.670365847 0.107402669 1 2.408075803 3.997480111 135112 nuclear receptor coactivator 7 "GO:0005515,GO:0005634,GO:0006979,GO:0030374,GO:0035257,GO:0045944,GO:1900408,GO:1902083,GO:1903204" protein binding|nucleus|response to oxidative stress|nuclear receptor coactivator activity|nuclear hormone receptor binding|positive regulation of transcription by RNA polymerase II|negative regulation of cellular response to oxidative stress|negative regulation of peptidyl-cysteine S-nitrosylation|negative regulation of oxidative stress-induced neuron death NCOR1 4720.743041 4435.357582 5006.1285 1.128686562 0.174644903 0.585755821 1 17.53729522 20.64675941 9611 nuclear receptor corepressor 1 "GO:0000118,GO:0000122,GO:0000785,GO:0000976,GO:0001102,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006325,GO:0007623,GO:0016020,GO:0016580,GO:0017053,GO:0019216,GO:0035257,GO:0042826,GO:0045475,GO:0045820,GO:0045892,GO:0045922,GO:0046329,GO:0046966,GO:0051225,GO:0060766,GO:0072686,GO:1903799" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|chromatin organization|circadian rhythm|membrane|Sin3 complex|transcription repressor complex|regulation of lipid metabolic process|nuclear hormone receptor binding|histone deacetylase binding|locomotor rhythm|negative regulation of glycolytic process|negative regulation of transcription, DNA-templated|negative regulation of fatty acid metabolic process|negative regulation of JNK cascade|thyroid hormone receptor binding|spindle assembly|negative regulation of androgen receptor signaling pathway|mitotic spindle|negative regulation of production of miRNAs involved in gene silencing by miRNA" "hsa01522,hsa04919,hsa05202" Endocrine resistance|Thyroid hormone signaling pathway|Transcriptional misregulation in cancer MYB NCOR2 5454.940713 6131.349005 4778.53242 0.779360695 -0.359636921 0.265123782 1 34.49963304 28.04586923 9612 nuclear receptor corepressor 2 "GO:0000118,GO:0000122,GO:0000785,GO:0000977,GO:0003682,GO:0003714,GO:0005112,GO:0005515,GO:0005634,GO:0005654,GO:0007595,GO:0010243,GO:0010565,GO:0016020,GO:0016363,GO:0016604,GO:0017053,GO:0019216,GO:0032355,GO:0035257,GO:0035259,GO:0042826,GO:0044849,GO:0044877,GO:0045892,GO:0046965,GO:0047485,GO:0060766,GO:1903799" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|transcription corepressor activity|Notch binding|protein binding|nucleus|nucleoplasm|lactation|response to organonitrogen compound|regulation of cellular ketone metabolic process|membrane|nuclear matrix|nuclear body|transcription repressor complex|regulation of lipid metabolic process|response to estradiol|nuclear hormone receptor binding|glucocorticoid receptor binding|histone deacetylase binding|estrous cycle|protein-containing complex binding|negative regulation of transcription, DNA-templated|retinoid X receptor binding|protein N-terminus binding|negative regulation of androgen receptor signaling pathway|negative regulation of production of miRNAs involved in gene silencing by miRNA" "hsa04330,hsa05169" Notch signaling pathway|Epstein-Barr virus infection MYB NCR3LG1 187.5253624 224.305269 150.7454557 0.672054903 -0.573348998 0.298305052 1 1.687252424 1.182771209 374383 natural killer cell cytotoxicity receptor 3 ligand 1 "GO:0005515,GO:0005886,GO:0016021,GO:0050776" protein binding|plasma membrane|integral component of membrane|regulation of immune response NCS1 1523.661939 1343.801702 1703.522176 1.267688658 0.342200466 0.301196598 1 12.65974992 16.73993091 23413 neuronal calcium sensor 1 "GO:0000287,GO:0005245,GO:0005509,GO:0005515,GO:0005737,GO:0005794,GO:0005886,GO:0010975,GO:0014069,GO:0019901,GO:0030425,GO:0031045,GO:0043231,GO:0044305,GO:0045921,GO:0048015,GO:0048471,GO:0070588,GO:0098978,GO:0099509,GO:0099523,GO:0099524,GO:0099626,GO:2000300" magnesium ion binding|voltage-gated calcium channel activity|calcium ion binding|protein binding|cytoplasm|Golgi apparatus|plasma membrane|regulation of neuron projection development|postsynaptic density|protein kinase binding|dendrite|dense core granule|intracellular membrane-bounded organelle|calyx of Held|positive regulation of exocytosis|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|calcium ion transmembrane transport|glutamatergic synapse|regulation of presynaptic cytosolic calcium ion concentration|presynaptic cytosol|postsynaptic cytosol|voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels|regulation of synaptic vesicle exocytosis NCSTN 2734.660286 2765.755014 2703.565559 0.977514475 -0.03281003 0.919068131 1 36.96905106 37.69445163 23385 nicastrin "GO:0002262,GO:0004175,GO:0005515,GO:0005739,GO:0005765,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005925,GO:0006508,GO:0006509,GO:0007212,GO:0007215,GO:0007220,GO:0007611,GO:0008021,GO:0010008,GO:0010950,GO:0016020,GO:0016021,GO:0016485,GO:0021549,GO:0022010,GO:0030534,GO:0030674,GO:0031293,GO:0034205,GO:0035333,GO:0035577,GO:0042098,GO:0042383,GO:0042470,GO:0042982,GO:0042983,GO:0042986,GO:0042987,GO:0043065,GO:0043085,GO:0043312,GO:0044267,GO:0048013,GO:0050673,GO:0051117,GO:0051402,GO:0070062,GO:0070765,GO:0070851,GO:0071277,GO:0099056,GO:1900271,GO:1990926" "myeloid cell homeostasis|endopeptidase activity|protein binding|mitochondrion|lysosomal membrane|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|focal adhesion|proteolysis|membrane protein ectodomain proteolysis|dopamine receptor signaling pathway|glutamate receptor signaling pathway|Notch receptor processing|learning or memory|synaptic vesicle|endosome membrane|positive regulation of endopeptidase activity|membrane|integral component of membrane|protein processing|cerebellum development|central nervous system myelination|adult behavior|protein-macromolecule adaptor activity|membrane protein intracellular domain proteolysis|amyloid-beta formation|Notch receptor processing, ligand-dependent|azurophil granule membrane|T cell proliferation|sarcolemma|melanosome|amyloid precursor protein metabolic process|amyloid precursor protein biosynthetic process|positive regulation of amyloid precursor protein biosynthetic process|amyloid precursor protein catabolic process|positive regulation of apoptotic process|positive regulation of catalytic activity|neutrophil degranulation|cellular protein metabolic process|ephrin receptor signaling pathway|epithelial cell proliferation|ATPase binding|neuron apoptotic process|extracellular exosome|gamma-secretase complex|growth factor receptor binding|cellular response to calcium ion|integral component of presynaptic membrane|regulation of long-term synaptic potentiation|short-term synaptic potentiation" "hsa04330,hsa05010" Notch signaling pathway|Alzheimer disease NDC1 2388.515518 2440.969104 2336.061932 0.957022327 -0.063375512 0.843793052 1 26.07053435 26.02483185 55706 NDC1 transmembrane nucleoporin "GO:0005635,GO:0005643,GO:0005737,GO:0005886,GO:0006110,GO:0006406,GO:0006409,GO:0006999,GO:0007129,GO:0007283,GO:0015031,GO:0015629,GO:0016020,GO:0016021,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0043657,GO:0051292,GO:0051664,GO:0060964,GO:0070762,GO:0075733,GO:1900034" nuclear envelope|nuclear pore|cytoplasm|plasma membrane|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nuclear pore organization|homologous chromosome pairing at meiosis|spermatogenesis|protein transport|actin cytoskeleton|membrane|integral component of membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|host cell|nuclear pore complex assembly|nuclear pore localization|regulation of gene silencing by miRNA|nuclear pore transmembrane ring|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NDC80 1052.399476 885.0416044 1219.757348 1.3781921 0.462776993 0.185461473 1 21.08383585 30.30925855 10403 NDC80 kinetochore complex component "GO:0000070,GO:0000132,GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0000778,GO:0000942,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0007052,GO:0007059,GO:0008608,GO:0016020,GO:0031262,GO:0042802,GO:0051298,GO:0051301,GO:0051310,GO:0051315,GO:0051383,GO:0090267,GO:1905342" "mitotic sister chromatid segregation|establishment of mitotic spindle orientation|mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome kinetochore|condensed nuclear chromosome outer kinetochore|protein binding|nucleus|nucleoplasm|centrosome|cytosol|mitotic spindle organization|chromosome segregation|attachment of spindle microtubules to kinetochore|membrane|Ndc80 complex|identical protein binding|centrosome duplication|cell division|metaphase plate congression|attachment of mitotic spindle microtubules to kinetochore|kinetochore organization|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of protein localization to kinetochore" NDE1 1212.446798 1049.464471 1375.429125 1.310600943 0.390228475 0.253325261 1 7.788932178 10.64790893 54820 nudE neurodevelopment protein 1 "GO:0000086,GO:0000132,GO:0000776,GO:0000777,GO:0005515,GO:0005813,GO:0005829,GO:0005871,GO:0005874,GO:0007020,GO:0007059,GO:0007100,GO:0008017,GO:0010389,GO:0016020,GO:0016477,GO:0021987,GO:0030154,GO:0031616,GO:0032154,GO:0042802,GO:0047496,GO:0051298,GO:0051301,GO:0051303,GO:0051642,GO:0097711,GO:2000574" G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|kinetochore|condensed chromosome kinetochore|protein binding|centrosome|cytosol|kinesin complex|microtubule|microtubule nucleation|chromosome segregation|mitotic centrosome separation|microtubule binding|regulation of G2/M transition of mitotic cell cycle|membrane|cell migration|cerebral cortex development|cell differentiation|spindle pole centrosome|cleavage furrow|identical protein binding|vesicle transport along microtubule|centrosome duplication|cell division|establishment of chromosome localization|centrosome localization|ciliary basal body-plasma membrane docking|regulation of microtubule motor activity NDEL1 1046.942665 983.4923334 1110.392997 1.129030659 0.175084664 0.617709159 1 11.71183097 13.79261016 81565 nudE neurodevelopment protein 1 like 1 "GO:0000132,GO:0000776,GO:0000777,GO:0001764,GO:0001833,GO:0005515,GO:0005635,GO:0005813,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0006508,GO:0007020,GO:0007059,GO:0007100,GO:0008017,GO:0008021,GO:0008090,GO:0008286,GO:0010975,GO:0016477,GO:0021799,GO:0021955,GO:0031252,GO:0032418,GO:0033157,GO:0042802,GO:0043014,GO:0043203,GO:0043547,GO:0044877,GO:0045773,GO:0047496,GO:0048487,GO:0048680,GO:0051081,GO:0051303,GO:0051642,GO:0060052,GO:0060053,GO:0070012,GO:0090630,GO:0090724,GO:1900029,GO:1904115,GO:1990138,GO:2000574" establishment of mitotic spindle orientation|kinetochore|condensed chromosome kinetochore|neuron migration|inner cell mass cell proliferation|protein binding|nuclear envelope|centrosome|spindle|cytosol|kinesin complex|microtubule|proteolysis|microtubule nucleation|chromosome segregation|mitotic centrosome separation|microtubule binding|synaptic vesicle|retrograde axonal transport|insulin receptor signaling pathway|regulation of neuron projection development|cell migration|cerebral cortex radially oriented cell migration|central nervous system neuron axonogenesis|cell leading edge|lysosome localization|regulation of intracellular protein transport|identical protein binding|alpha-tubulin binding|axon hillock|positive regulation of GTPase activity|protein-containing complex binding|positive regulation of axon extension|vesicle transport along microtubule|beta-tubulin binding|positive regulation of axon regeneration|nuclear envelope disassembly|establishment of chromosome localization|centrosome localization|neurofilament cytoskeleton organization|neurofilament cytoskeleton|oligopeptidase activity|activation of GTPase activity|central region of growth cone|positive regulation of ruffle assembly|axon cytoplasm|neuron projection extension|regulation of microtubule motor activity NDFIP1 1401.335251 1400.639236 1402.031265 1.000993852 0.001433114 0.999034801 1 19.84819143 20.72374691 80762 Nedd4 family interacting protein 1 "GO:0000139,GO:0002761,GO:0002829,GO:0005515,GO:0005576,GO:0005783,GO:0005794,GO:0005938,GO:0006511,GO:0006879,GO:0007034,GO:0010008,GO:0010629,GO:0016021,GO:0030001,GO:0030425,GO:0031398,GO:0032410,GO:0032713,GO:0042130,GO:0043123,GO:0045202,GO:0045619,GO:0045732,GO:0048294,GO:0048302,GO:0048471,GO:0050699,GO:0050728,GO:0051224" Golgi membrane|regulation of myeloid leukocyte differentiation|negative regulation of type 2 immune response|protein binding|extracellular region|endoplasmic reticulum|Golgi apparatus|cell cortex|ubiquitin-dependent protein catabolic process|cellular iron ion homeostasis|vacuolar transport|endosome membrane|negative regulation of gene expression|integral component of membrane|metal ion transport|dendrite|positive regulation of protein ubiquitination|negative regulation of transporter activity|negative regulation of interleukin-4 production|negative regulation of T cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB signaling|synapse|regulation of lymphocyte differentiation|positive regulation of protein catabolic process|negative regulation of isotype switching to IgE isotypes|regulation of isotype switching to IgG isotypes|perinuclear region of cytoplasm|WW domain binding|negative regulation of inflammatory response|negative regulation of protein transport NDFIP2 725.9788009 696.2597943 755.6978075 1.085367579 0.11818372 0.755057016 1 6.973126819 7.894422002 54602 Nedd4 family interacting protein 2 "GO:0000139,GO:0005515,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0006511,GO:0007034,GO:0010629,GO:0016021,GO:0030001,GO:0031398,GO:0032410,GO:0032585,GO:0043123,GO:0043231,GO:0048471,GO:0050699,GO:0051224" Golgi membrane|protein binding|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|ubiquitin-dependent protein catabolic process|vacuolar transport|negative regulation of gene expression|integral component of membrane|metal ion transport|positive regulation of protein ubiquitination|negative regulation of transporter activity|multivesicular body membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|WW domain binding|negative regulation of protein transport NDNF 8.075110419 13.19442759 2.95579325 0.224018301 -2.158311499 0.176784179 1 0.070572522 0.016490547 79625 neuron derived neurotrophic factor "GO:0001525,GO:0001764,GO:0002931,GO:0005539,GO:0005576,GO:0005615,GO:0007263,GO:0008201,GO:0010811,GO:0010976,GO:0019800,GO:0021828,GO:0030198,GO:0031012,GO:0043524,GO:0044344,GO:0061042,GO:0071456,GO:2000352" angiogenesis|neuron migration|response to ischemia|glycosaminoglycan binding|extracellular region|extracellular space|nitric oxide mediated signal transduction|heparin binding|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|extracellular matrix organization|extracellular matrix|negative regulation of neuron apoptotic process|cellular response to fibroblast growth factor stimulus|vascular wound healing|cellular response to hypoxia|negative regulation of endothelial cell apoptotic process NDOR1 1025.91066 960.1483461 1091.672974 1.136983653 0.185211511 0.598662304 1 9.970909684 11.82510301 27158 NADPH dependent diflavin oxidoreductase 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008219,GO:0010181,GO:0016226,GO:0016491,GO:0016709,GO:0036245,GO:0045111,GO:0048471,GO:0050660,GO:0050661,GO:0055114" "protein binding|nucleoplasm|cytoplasm|cytosol|cell death|FMN binding|iron-sulfur cluster assembly|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|cellular response to menadione|intermediate filament cytoskeleton|perinuclear region of cytoplasm|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process" NDRG1 9451.207366 15631.33687 3271.077863 0.209264114 -2.256603164 1.21E-10 1.63E-07 159.130064 34.73464995 10397 N-myc downstream regulated 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0005886,GO:0005912,GO:0007165,GO:0008017,GO:0008285,GO:0010038,GO:0015630,GO:0030330,GO:0031267,GO:0032287,GO:0042981,GO:0043015,GO:0045296,GO:0045576,GO:0048471,GO:0055038,GO:0070062,GO:0071456,GO:0098978,GO:0099173" "protein binding|nucleus|cytoplasm|centrosome|cytosol|microtubule|plasma membrane|adherens junction|signal transduction|microtubule binding|negative regulation of cell population proliferation|response to metal ion|microtubule cytoskeleton|DNA damage response, signal transduction by p53 class mediator|small GTPase binding|peripheral nervous system myelin maintenance|regulation of apoptotic process|gamma-tubulin binding|cadherin binding|mast cell activation|perinuclear region of cytoplasm|recycling endosome membrane|extracellular exosome|cellular response to hypoxia|glutamatergic synapse|postsynapse organization" NDRG2 126.776462 112.6601125 140.8928116 1.250600665 0.322621189 0.612411728 1 1.564528998 2.040883441 57447 NDRG family member 2 "GO:0001818,GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0007165,GO:0010574,GO:0016055,GO:0021762,GO:0030154,GO:0030426,GO:0048471,GO:0048662,GO:0070062,GO:0070373,GO:0090361" negative regulation of cytokine production|molecular_function|protein binding|nucleus|cytoplasm|Golgi apparatus|cytosol|signal transduction|regulation of vascular endothelial growth factor production|Wnt signaling pathway|substantia nigra development|cell differentiation|growth cone|perinuclear region of cytoplasm|negative regulation of smooth muscle cell proliferation|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|regulation of platelet-derived growth factor production NDRG3 2151.596044 2174.035684 2129.156404 0.979356696 -0.030093689 0.926707047 1 30.50907117 31.16634061 57446 NDRG family member 3 "GO:0003674,GO:0005737,GO:0007165,GO:0007283,GO:0030154,GO:0030308,GO:0070062" molecular_function|cytoplasm|signal transduction|spermatogenesis|cell differentiation|negative regulation of cell growth|extracellular exosome NDRG4 229.4908963 196.9014579 262.0803348 1.331022826 0.412535312 0.425155676 1 2.095474725 2.909268869 65009 NDRG family member 4 "GO:0001947,GO:0003674,GO:0005515,GO:0005737,GO:0005739,GO:0005789,GO:0005829,GO:0007165,GO:0007420,GO:0008542,GO:0010642,GO:0010976,GO:0014912,GO:0016323,GO:0030154,GO:0031253,GO:0035050,GO:0048278,GO:0048662,GO:0060038,GO:0060973,GO:0070374,GO:2001135" heart looping|molecular_function|protein binding|cytoplasm|mitochondrion|endoplasmic reticulum membrane|cytosol|signal transduction|brain development|visual learning|negative regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of neuron projection development|negative regulation of smooth muscle cell migration|basolateral plasma membrane|cell differentiation|cell projection membrane|embryonic heart tube development|vesicle docking|negative regulation of smooth muscle cell proliferation|cardiac muscle cell proliferation|cell migration involved in heart development|positive regulation of ERK1 and ERK2 cascade|regulation of endocytic recycling NDST1 3606.610392 3977.61244 3235.608344 0.813454904 -0.297865727 0.349371073 1 24.53142205 20.81479489 3340 N-deacetylase and N-sulfotransferase 1 "GO:0000139,GO:0003279,GO:0005515,GO:0005794,GO:0006024,GO:0006477,GO:0006954,GO:0007585,GO:0008283,GO:0008543,GO:0015014,GO:0015016,GO:0016021,GO:0019213,GO:0030210,GO:0030900,GO:0030901,GO:0035904,GO:0043410,GO:0045880,GO:0048702,GO:0048703,GO:0060976,GO:0102140" "Golgi membrane|cardiac septum development|protein binding|Golgi apparatus|glycosaminoglycan biosynthetic process|protein sulfation|inflammatory response|respiratory gaseous exchange by respiratory system|cell population proliferation|fibroblast growth factor receptor signaling pathway|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|deacetylase activity|heparin biosynthetic process|forebrain development|midbrain development|aorta development|positive regulation of MAPK cascade|positive regulation of smoothened signaling pathway|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|coronary vasculature development|heparan sulfate N-deacetylase activity" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDST2 1056.05698 1067.733679 1044.380282 0.978128069 -0.031904721 0.929954478 1 11.25664948 11.48473013 8509 N-deacetylase and N-sulfotransferase 2 "GO:0000139,GO:0005794,GO:0006024,GO:0015014,GO:0015016,GO:0016021,GO:0019213,GO:0030210" "Golgi membrane|Golgi apparatus|glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|deacetylase activity|heparin biosynthetic process" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDST3 7.971189988 6.08973581 9.852644165 1.617909951 0.694131313 0.702268135 1 0.023174065 0.039108621 9348 N-deacetylase and N-sulfotransferase 3 "GO:0000139,GO:0005575,GO:0005794,GO:0015012,GO:0015014,GO:0015016,GO:0016021,GO:0019213,GO:0030210,GO:0102140" "Golgi membrane|cellular_component|Golgi apparatus|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|deacetylase activity|heparin biosynthetic process|heparan sulfate N-deacetylase activity" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDUFA1 1476.533788 1523.448909 1429.618668 0.938409329 -0.091710739 0.783947614 1 183.2715269 179.3920714 4694 NADH:ubiquinone oxidoreductase subunit A1 "GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0031966,GO:0032981" "mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA10 1079.077082 1058.599075 1099.555089 1.038688881 0.054763588 0.877363995 1 6.3142514 6.841058144 4705 NADH:ubiquinone oxidoreductase subunit A10 "GO:0005737,GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0006120,GO:0008137,GO:0032981" "cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA11 1039.740734 1063.673855 1015.807613 0.954999137 -0.066428665 0.851872506 1 20.42902098 20.35009605 126328 NADH:ubiquinone oxidoreductase subunit A11 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0016021,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA12 839.409656 805.8750389 872.9442731 1.083225352 0.11533341 0.753544762 1 72.62407075 82.05694314 55967 NADH:ubiquinone oxidoreductase subunit A12 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005829,GO:0006120,GO:0006979,GO:0007585,GO:0008137,GO:0009055,GO:0032981,GO:0042775" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|cytosol|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|respiratory gaseous exchange by respiratory system|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA13 1952.94526 1997.433346 1908.457175 0.955454748 -0.065740548 0.839925185 1 194.1707341 193.5128572 51079 NADH:ubiquinone oxidoreductase subunit A13 "GO:0003954,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005746,GO:0005747,GO:0006120,GO:0008137,GO:0010952,GO:0016021,GO:0016032,GO:0030308,GO:0031966,GO:0032981,GO:0035458,GO:0043280,GO:0045039,GO:0045732,GO:0045892,GO:0071300,GO:0072593,GO:0097190,GO:2001243" "NADH dehydrogenase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|positive regulation of peptidase activity|integral component of membrane|viral process|negative regulation of cell growth|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|cellular response to interferon-beta|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein insertion into mitochondrial inner membrane|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|cellular response to retinoic acid|reactive oxygen species metabolic process|apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA2 1127.691048 1148.930156 1106.45194 0.963028026 -0.054350312 0.877319218 1 83.60525751 83.98243153 4695 NADH:ubiquinone oxidoreductase subunit A2 "GO:0001835,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0031966,GO:0032981" "blastocyst hatching|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA3 824.9073163 892.1462962 757.6683363 0.849264677 -0.235713848 0.51949571 1 33.10187736 29.32321714 4696 NADH:ubiquinone oxidoreductase subunit A3 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA4 2309.670116 2371.952098 2247.388134 0.947484621 -0.077825569 0.808712752 1 59.03243539 58.34166237 4697 NDUFA4 mitochondrial complex associated "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005751,GO:0006120,GO:0006123,GO:0008137,GO:0016021,GO:0044877,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex IV|mitochondrial electron transport, NADH to ubiquinone|mitochondrial electron transport, cytochrome c to oxygen|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|protein-containing complex binding|proton transmembrane transport" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA4L2 13.98669692 13.19442759 14.77896625 1.120091504 0.163616596 0.957372196 1 0.562501019 0.657192724 56901 NDUFA4 mitochondrial complex associated like 2 "GO:0004129,GO:0005751,GO:0022900,GO:1902600" cytochrome-c oxidase activity|mitochondrial respiratory chain complex IV|electron transport chain|proton transmembrane transport "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA5 785.8193873 779.4861837 792.1525909 1.016249688 0.023254909 0.953394323 1 5.601337307 5.937560956 4698 NADH:ubiquinone oxidoreductase subunit A5 "GO:0005515,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0022904,GO:0032981" "protein binding|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|respiratory electron transport chain|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA6 1301.825028 1198.662999 1404.987058 1.172128496 0.229130736 0.498247368 1 56.63064576 69.23770564 4700 NADH:ubiquinone oxidoreductase subunit A6 "GO:0005743,GO:0005747,GO:0006120,GO:0006979,GO:0008137,GO:0031966,GO:0032981" "mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|mitochondrial membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA7 530.9491486 598.8240213 463.0742758 0.773306112 -0.370888479 0.357336704 1 52.29021406 42.17817576 4701 NADH:ubiquinone oxidoreductase subunit A7 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005761,GO:0006120,GO:0008137,GO:0032543,GO:0032981" "structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial ribosome|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial translation|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA8 944.0028229 917.5201954 970.4854503 1.057726528 0.080966671 0.822507696 1 35.3915926 39.04715823 4702 NADH:ubiquinone oxidoreductase subunit A8 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005758,GO:0006120,GO:0008137,GO:0032981,GO:0044877" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly|protein-containing complex binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA9 1558.42678 1565.062103 1551.791456 0.99152069 -0.012285218 0.972437484 1 9.485983045 9.810701333 4704 NADH:ubiquinone oxidoreductase subunit A9 "GO:0003954,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0006814,GO:0007623,GO:0008137,GO:0009749,GO:0031966,GO:0032981,GO:0044877,GO:1901006" "NADH dehydrogenase activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|sodium ion transport|circadian rhythm|NADH dehydrogenase (ubiquinone) activity|response to glucose|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|protein-containing complex binding|ubiquinone-6 biosynthetic process" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFAB1 669.3706343 699.3046622 639.4366063 0.914389165 -0.129119786 0.737546676 1 45.81800018 43.70017043 4706 NADH:ubiquinone oxidoreductase subunit AB1 "GO:0000035,GO:0000036,GO:0005504,GO:0005509,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0005762,GO:0006120,GO:0006633,GO:0008137,GO:0009249,GO:0031966,GO:0032981" "acyl binding|acyl carrier activity|fatty acid binding|calcium ion binding|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial large ribosomal subunit|mitochondrial electron transport, NADH to ubiquinone|fatty acid biosynthetic process|NADH dehydrogenase (ubiquinone) activity|protein lipoylation|mitochondrial membrane|mitochondrial respiratory chain complex I assembly" "hsa00061,hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Fatty acid biosynthesis|Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFAF1 151.8034652 207.0510175 96.55591282 0.466338751 -1.100549779 0.063564233 1 6.926290361 3.369132789 51103 NADH:ubiquinone oxidoreductase complex assembly factor 1 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0005829,GO:0006120,GO:0010257,GO:0032981,GO:0051082,GO:0051131,GO:0065003" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|cytosol|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase complex assembly|mitochondrial respiratory chain complex I assembly|unfolded protein binding|chaperone-mediated protein complex assembly|protein-containing complex assembly" hsa04714 Thermogenesis NDUFAF2 340.8418589 366.3991046 315.2846133 0.860495043 -0.216761213 0.636666766 1 29.36206024 26.3542601 91942 NADH:ubiquinone oxidoreductase complex assembly factor 2 "GO:0005515,GO:0005739,GO:0005743,GO:0008137,GO:0009055,GO:0022900,GO:0032981,GO:0044877" protein binding|mitochondrion|mitochondrial inner membrane|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|electron transport chain|mitochondrial respiratory chain complex I assembly|protein-containing complex binding hsa04714 Thermogenesis NDUFAF3 1121.141093 1105.28705 1136.995137 1.028687649 0.040804989 0.908572566 1 38.02913712 40.80523907 25915 NADH:ubiquinone oxidoreductase complex assembly factor 3 "GO:0005515,GO:0005634,GO:0005743,GO:0032981" protein binding|nucleus|mitochondrial inner membrane|mitochondrial respiratory chain complex I assembly hsa04714 Thermogenesis NDUFAF4 141.1491491 152.2433953 130.054903 0.854256454 -0.227258852 0.714404335 1 3.203402944 2.854406153 29078 NADH:ubiquinone oxidoreductase complex assembly factor 4 "GO:0005515,GO:0005516,GO:0005739,GO:0005743,GO:0031966,GO:0032981" protein binding|calmodulin binding|mitochondrion|mitochondrial inner membrane|mitochondrial membrane|mitochondrial respiratory chain complex I assembly hsa04714 Thermogenesis NDUFAF5 256.2212044 273.0231555 239.4192532 0.876919222 -0.18948414 0.708102973 1 5.795330955 5.300950663 79133 NADH:ubiquinone oxidoreductase complex assembly factor 5 "GO:0003674,GO:0005515,GO:0005739,GO:0005743,GO:0008168,GO:0016491,GO:0030961,GO:0031314,GO:0032259,GO:0032981,GO:0055114" molecular_function|protein binding|mitochondrion|mitochondrial inner membrane|methyltransferase activity|oxidoreductase activity|peptidyl-arginine hydroxylation|extrinsic component of mitochondrial inner membrane|methylation|mitochondrial respiratory chain complex I assembly|oxidation-reduction process hsa04714 Thermogenesis NDUFAF6 331.7099768 314.6363502 348.7836035 1.10852927 0.148646864 0.750334839 1 3.704142531 4.283026721 137682 NADH:ubiquinone oxidoreductase complex assembly factor 6 "GO:0005634,GO:0005739,GO:0005743,GO:0032981" nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I assembly hsa04714 Thermogenesis NDUFAF7 279.0037737 247.6492563 310.3582912 1.253217134 0.3256364 0.503155396 1 2.995596173 3.915845251 55471 NADH:ubiquinone oxidoreductase complex assembly factor 7 "GO:0005515,GO:0005615,GO:0005739,GO:0005759,GO:0008168,GO:0019899,GO:0019918,GO:0032981,GO:0035243" "protein binding|extracellular space|mitochondrion|mitochondrial matrix|methyltransferase activity|enzyme binding|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|mitochondrial respiratory chain complex I assembly|protein-arginine omega-N symmetric methyltransferase activity" hsa04714 Thermogenesis NDUFAF8 257.5357974 261.8586398 253.2129551 0.966983389 -0.048436987 0.930344483 1 23.18569288 23.3859503 284184 NADH:ubiquinone oxidoreductase complex assembly factor 8 "GO:0005515,GO:0005739,GO:0032981" protein binding|mitochondrion|mitochondrial respiratory chain complex I assembly NDUFB1 645.0953225 723.6636055 566.5270395 0.782859654 -0.353174402 0.358778714 1 115.6183239 94.41185057 4707 NADH:ubiquinone oxidoreductase subunit B1 "GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0016607,GO:0032981" "mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|nuclear speck|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB10 1156.956024 1263.620181 1050.291868 0.831176871 -0.266772585 0.438430279 1 94.81171017 82.19991335 4716 NADH:ubiquinone oxidoreductase subunit B10 "GO:0005515,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0032981" "protein binding|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB11 1724.536868 1706.140983 1742.932753 1.02156432 0.030780042 0.926648085 1 140.2760095 149.4737907 54539 NADH:ubiquinone oxidoreductase subunit B11 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0016021,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB2 918.252336 908.3855917 928.1190804 1.021723692 0.031005096 0.934080059 1 98.93876479 105.4425445 4708 NADH:ubiquinone oxidoreductase subunit B2 "GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0032981" "mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB3 558.9373882 626.2278325 491.6469439 0.78509277 -0.349064955 0.380473352 1 20.01024007 16.38661337 4709 NADH:ubiquinone oxidoreductase subunit B3 "GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981" "mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB4 1931.563637 2051.226012 1811.901262 0.883325997 -0.178982123 0.580099457 1 64.88904511 59.78721521 4710 NADH:ubiquinone oxidoreductase subunit B4 "GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0006979,GO:0008137,GO:0016021,GO:0032981" "nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB5 917.3237331 945.9389625 888.7085037 0.939498783 -0.090036803 0.803715778 1 11.40949545 11.18094705 4711 NADH:ubiquinone oxidoreductase subunit B5 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981" "protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB6 912.2786448 937.8193148 886.7379749 0.945531789 -0.080802131 0.824037786 1 34.89878021 34.41932207 4712 NADH:ubiquinone oxidoreductase subunit B6 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0031966,GO:0032981,GO:0042775" "protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB7 890.3059122 917.5201954 863.0916289 0.940678617 -0.088226184 0.80877737 1 35.28410105 34.62073304 4713 NADH:ubiquinone oxidoreductase subunit B7 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005758,GO:0006120,GO:0008137,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB8 4137.228974 4419.118286 3855.339662 0.872422826 -0.196900579 0.537180998 1 235.3446388 214.1643892 4714 NADH:ubiquinone oxidoreductase subunit B8 "GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0005783,GO:0006120,GO:0008137,GO:0016021,GO:0032981" "mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|endoplasmic reticulum|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB9 4192.965199 4491.18016 3894.750239 0.867199734 -0.205563781 0.51954793 1 329.1786269 297.7602325 4715 NADH:ubiquinone oxidoreductase subunit B9 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0007605,GO:0008137,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|sensory perception of sound|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFC1 581.209758 633.3325243 529.0869917 0.83540158 -0.259458222 0.511297831 1 23.2603757 20.2687958 4717 NADH:ubiquinone oxidoreductase subunit C1 "GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981" "mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFC2 157.406012 152.2433953 162.5686287 1.067820568 0.094669242 0.88130385 1 3.556545612 3.961344332 4718 NADH:ubiquinone oxidoreductase subunit C2 "GO:0005737,GO:0005739,GO:0005743,GO:0005747,GO:0005886,GO:0006120,GO:0008137,GO:0016021,GO:0032981,GO:0035577,GO:0043312" "cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|plasma membrane|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly|azurophil granule membrane|neutrophil degranulation" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS1 2417.655047 2446.043884 2389.26621 0.976787958 -0.03388268 0.916755562 1 10.52178475 10.72026792 4719 NADH:ubiquinone oxidoreductase core subunit S1 "GO:0005515,GO:0005739,GO:0005747,GO:0005758,GO:0005759,GO:0006120,GO:0008137,GO:0008637,GO:0009055,GO:0032981,GO:0045333,GO:0046034,GO:0046872,GO:0051537,GO:0051539,GO:0051881,GO:0072593" "protein binding|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|apoptotic mitochondrial changes|electron transfer activity|mitochondrial respiratory chain complex I assembly|cellular respiration|ATP metabolic process|metal ion binding|2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|regulation of mitochondrial membrane potential|reactive oxygen species metabolic process" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS2 1907.727018 2004.538038 1810.915998 0.903408149 -0.146550168 0.651151794 1 39.07728253 36.82343414 4720 NADH:ubiquinone oxidoreductase core subunit S2 "GO:0003954,GO:0005515,GO:0005654,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0006979,GO:0008137,GO:0009055,GO:0031625,GO:0032981,GO:0042775,GO:0046872,GO:0048038,GO:0051287,GO:0051539" "NADH dehydrogenase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|ubiquitin protein ligase binding|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport|metal ion binding|quinone binding|NAD binding|4 iron, 4 sulfur cluster binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS3 1038.683962 1025.105528 1052.262397 1.026491779 0.037722073 0.916937482 1 58.07380161 62.18013517 4722 NADH:ubiquinone oxidoreductase core subunit S3 "GO:0003954,GO:0005515,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0008137,GO:0009055,GO:0016604,GO:0021762,GO:0030308,GO:0031966,GO:0032981,GO:0072593,GO:2001243" "NADH dehydrogenase activity|protein binding|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|nuclear body|substantia nigra development|negative regulation of cell growth|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|reactive oxygen species metabolic process|negative regulation of intrinsic apoptotic signaling pathway" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS4 783.5843561 727.7234293 839.4452829 1.153522408 0.20604603 0.577782723 1 38.55295444 46.3873572 4724 NADH:ubiquinone oxidoreductase subunit S4 "GO:0001932,GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0007420,GO:0008137,GO:0019933,GO:0032981,GO:0045333,GO:0048146,GO:0051591,GO:0072593" "regulation of protein phosphorylation|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|brain development|NADH dehydrogenase (ubiquinone) activity|cAMP-mediated signaling|mitochondrial respiratory chain complex I assembly|cellular respiration|positive regulation of fibroblast proliferation|response to cAMP|reactive oxygen species metabolic process" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS5 3303.405781 3388.937978 3217.873584 0.949522713 -0.074725584 0.814939717 1 349.5677254 346.22037 4725 NADH:ubiquinone oxidoreductase subunit S5 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005758,GO:0006120,GO:0008137,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS6 1270.027859 1382.370029 1157.685689 0.837464402 -0.255900228 0.450887451 1 135.1586202 118.0663221 4726 NADH:ubiquinone oxidoreductase subunit S6 "GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0009055,GO:0032981" "mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS7 786.8343433 781.5160956 792.1525909 1.013610078 0.019502774 0.961536979 1 20.83212275 22.02522612 374291 NADH:ubiquinone oxidoreductase core subunit S7 "GO:0003954,GO:0005515,GO:0005747,GO:0005759,GO:0006120,GO:0008137,GO:0009060,GO:0015990,GO:0016655,GO:0032981,GO:0046872,GO:0048038,GO:0051539" "NADH dehydrogenase activity|protein binding|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|aerobic respiration|electron transport coupled proton transport|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|mitochondrial respiratory chain complex I assembly|metal ion binding|quinone binding|4 iron, 4 sulfur cluster binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS8 1951.772444 1917.251824 1986.293064 1.036010522 0.051038656 0.875800336 1 131.7531089 142.3773705 4728 NADH:ubiquinone oxidoreductase core subunit S8 "GO:0003954,GO:0005515,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0006979,GO:0008137,GO:0009060,GO:0032981,GO:0046872,GO:0051539" "NADH dehydrogenase activity|protein binding|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|aerobic respiration|mitochondrial respiratory chain complex I assembly|metal ion binding|4 iron, 4 sulfur cluster binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFV1 2614.566153 2537.389921 2691.742386 1.060831197 0.085195107 0.790085 1 83.82899421 92.75908757 4723 NADH:ubiquinone oxidoreductase core subunit V1 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005829,GO:0006120,GO:0008137,GO:0010181,GO:0032981,GO:0042775,GO:0046872,GO:0051287,GO:0051539" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|cytosol|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|FMN binding|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport|metal ion binding|NAD binding|4 iron, 4 sulfur cluster binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFV2 1896.636731 1987.283786 1805.989676 0.908772913 -0.13800826 0.670491537 1 82.83861156 78.52430747 4729 NADH:ubiquinone oxidoreductase core subunit V2 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0005829,GO:0006120,GO:0007399,GO:0008137,GO:0009055,GO:0032981,GO:0046872,GO:0048738,GO:0051537" "protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|cytosol|mitochondrial electron transport, NADH to ubiquinone|nervous system development|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|mitochondrial respiratory chain complex I assembly|metal ion binding|cardiac muscle tissue development|2 iron, 2 sulfur cluster binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFV3 808.4453341 844.4433657 772.4473026 0.914741395 -0.128564155 0.727968412 1 7.34089898 7.004280183 4731 NADH:ubiquinone oxidoreductase subunit V3 "GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0032981,GO:0042775" "RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NEB 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.005675603 0.009578165 4703 nebulin "GO:0005515,GO:0005829,GO:0007517,GO:0007525,GO:0008307,GO:0015629,GO:0030018,GO:0030049,GO:0030832,GO:0048747,GO:0051015,GO:0070062,GO:0071691" protein binding|cytosol|muscle organ development|somatic muscle development|structural constituent of muscle|actin cytoskeleton|Z disc|muscle filament sliding|regulation of actin filament length|muscle fiber development|actin filament binding|extracellular exosome|cardiac muscle thin filament assembly NECAB2 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.073856235 0.037392 54550 N-terminal EF-hand calcium binding protein 2 "GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0030424,GO:0030425,GO:0031687,GO:0031802,GO:0042984,GO:0060168,GO:0070374,GO:1900451,GO:1904021,GO:1905477" calcium ion binding|protein binding|cytoplasm|plasma membrane|axon|dendrite|A2A adenosine receptor binding|type 5 metabotropic glutamate receptor binding|regulation of amyloid precursor protein biosynthetic process|positive regulation of adenosine receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of glutamate receptor signaling pathway|negative regulation of G protein-coupled receptor internalization|positive regulation of protein localization to membrane NECAB3 569.1302474 481.089129 657.1713658 1.366007515 0.449965421 0.255900682 1 11.44455951 16.30677581 63941 N-terminal EF-hand calcium binding protein 3 "GO:0000137,GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0009306,GO:0019538,GO:0042984" Golgi cis cisterna|calcium ion binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein secretion|protein metabolic process|regulation of amyloid precursor protein biosynthetic process NECAP1 465.2954529 589.6894176 340.9014881 0.578103452 -0.790600407 0.058090426 1 11.33853026 6.837199561 25977 NECAP endocytosis associated 1 "GO:0005515,GO:0005829,GO:0005905,GO:0006897,GO:0015031,GO:0016192,GO:0030125,GO:0061024" protein binding|cytosol|clathrin-coated pit|endocytosis|protein transport|vesicle-mediated transport|clathrin vesicle coat|membrane organization NECAP2 1425.047907 1135.735729 1714.360085 1.509470946 0.594042989 0.075528604 1 26.45860534 41.65888448 55707 NECAP endocytosis associated 2 "GO:0005905,GO:0006897,GO:0015031,GO:0016192,GO:0030125" clathrin-coated pit|endocytosis|protein transport|vesicle-mediated transport|clathrin vesicle coat NECTIN1 121.6989606 136.0040998 107.3938214 0.789636648 -0.340739147 0.597151409 1 1.045398066 0.861043154 5818 nectin cell adhesion molecule 1 "GO:0001618,GO:0002089,GO:0002934,GO:0005515,GO:0005576,GO:0005886,GO:0005912,GO:0006826,GO:0006955,GO:0007155,GO:0007156,GO:0007157,GO:0007411,GO:0015026,GO:0016020,GO:0016021,GO:0019062,GO:0030246,GO:0030425,GO:0032584,GO:0034332,GO:0042802,GO:0042803,GO:0043231,GO:0043296,GO:0044291,GO:0044877,GO:0046718,GO:0046790,GO:0050839,GO:0051963,GO:0060041,GO:0070166,GO:0098609,GO:0098686,GO:0099059,GO:1902414" virus receptor activity|lens morphogenesis in camera-type eye|desmosome organization|protein binding|extracellular region|plasma membrane|adherens junction|iron ion transport|immune response|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axon guidance|coreceptor activity|membrane|integral component of membrane|virion attachment to host cell|carbohydrate binding|dendrite|growth cone membrane|adherens junction organization|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|apical junction complex|cell-cell contact zone|protein-containing complex binding|viral entry into host cell|virion binding|cell adhesion molecule binding|regulation of synapse assembly|retina development in camera-type eye|enamel mineralization|cell-cell adhesion|hippocampal mossy fiber to CA3 synapse|integral component of presynaptic active zone membrane|protein localization to cell junction "hsa04514,hsa04520,hsa05168" Cell adhesion molecules|Adherens junction|Herpes simplex virus 1 infection NECTIN2 1896.360104 1901.012529 1891.70768 0.995105319 -0.00707887 0.984370366 1 28.26763893 29.34097308 5819 nectin cell adhesion molecule 2 "GO:0001618,GO:0001675,GO:0002860,GO:0002891,GO:0005515,GO:0005886,GO:0005911,GO:0005915,GO:0005925,GO:0007010,GO:0007156,GO:0007286,GO:0007289,GO:0009566,GO:0009986,GO:0015026,GO:0016021,GO:0019064,GO:0030382,GO:0032990,GO:0033005,GO:0034332,GO:0042271,GO:0042802,GO:0042803,GO:0043296,GO:0044291,GO:0044406,GO:0044782,GO:0045954,GO:0046596,GO:0046814,GO:0050776,GO:0050839,GO:0050862,GO:0051654,GO:0060370,GO:0070062" virus receptor activity|acrosome assembly|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of immunoglobulin mediated immune response|protein binding|plasma membrane|cell-cell junction|zonula adherens|focal adhesion|cytoskeleton organization|homophilic cell adhesion via plasma membrane adhesion molecules|spermatid development|spermatid nucleus differentiation|fertilization|cell surface|coreceptor activity|integral component of membrane|fusion of virus membrane with host plasma membrane|sperm mitochondrion organization|cell part morphogenesis|positive regulation of mast cell activation|adherens junction organization|susceptibility to natural killer cell mediated cytotoxicity|identical protein binding|protein homodimerization activity|apical junction complex|cell-cell contact zone|adhesion of symbiont to host|cilium organization|positive regulation of natural killer cell mediated cytotoxicity|regulation of viral entry into host cell|coreceptor-mediated virion attachment to host cell|regulation of immune response|cell adhesion molecule binding|positive regulation of T cell receptor signaling pathway|establishment of mitochondrion localization|susceptibility to T cell mediated cytotoxicity|extracellular exosome "hsa04514,hsa04520,hsa05168" Cell adhesion molecules|Adherens junction|Herpes simplex virus 1 infection NECTIN3 883.6196237 898.236032 869.0032154 0.967455306 -0.047733081 0.897635652 1 6.103097161 6.158814514 25945 nectin cell adhesion molecule 3 "GO:0002089,GO:0005515,GO:0005886,GO:0005911,GO:0005912,GO:0007156,GO:0007157,GO:0007286,GO:0009566,GO:0030424,GO:0030425,GO:0034332,GO:0042803,GO:0043296,GO:0044291,GO:0050839,GO:0060042,GO:0061951,GO:0098686,GO:0099061,GO:1902414" lens morphogenesis in camera-type eye|protein binding|plasma membrane|cell-cell junction|adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|spermatid development|fertilization|axon|dendrite|adherens junction organization|protein homodimerization activity|apical junction complex|cell-cell contact zone|cell adhesion molecule binding|retina morphogenesis in camera-type eye|establishment of protein localization to plasma membrane|hippocampal mossy fiber to CA3 synapse|integral component of postsynaptic density membrane|protein localization to cell junction "hsa04514,hsa04520" Cell adhesion molecules|Adherens junction NEDD1 905.7435357 895.1911641 916.2959074 1.023575683 0.033617779 0.928469219 1 11.16431283 11.91977031 121441 NEDD1 gamma-tubulin ring complex targeting factor "GO:0000086,GO:0000242,GO:0000922,GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0010389,GO:0036064,GO:0045177,GO:0051301,GO:0071539,GO:0097711" G2/M transition of mitotic cell cycle|pericentriolar material|spindle pole|protein binding|nucleoplasm|centrosome|centriole|cytosol|plasma membrane|regulation of G2/M transition of mitotic cell cycle|ciliary basal body|apical part of cell|cell division|protein localization to centrosome|ciliary basal body-plasma membrane docking NEDD4 997.7606005 719.6037816 1275.917419 1.773083261 0.826260284 0.019594813 0.604436841 4.656963062 8.612869218 4734 NEDD4 E3 ubiquitin protein ligase "GO:0000151,GO:0000209,GO:0000785,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0005938,GO:0006511,GO:0006622,GO:0007041,GO:0007528,GO:0010766,GO:0010768,GO:0014068,GO:0016241,GO:0016327,GO:0016567,GO:0019871,GO:0019899,GO:0019904,GO:0030948,GO:0031175,GO:0031623,GO:0031698,GO:0032801,GO:0032991,GO:0034644,GO:0034765,GO:0042391,GO:0042921,GO:0043130,GO:0043161,GO:0043162,GO:0043197,GO:0044111,GO:0045732,GO:0046755,GO:0046824,GO:0048471,GO:0048814,GO:0050807,GO:0050815,GO:0050816,GO:0050847,GO:0051592,GO:0061630,GO:0070062,GO:0070063,GO:0070064,GO:0070534,GO:1901016,GO:2000650" ubiquitin ligase complex|protein polyubiquitination|chromatin|protein binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|cell cortex|ubiquitin-dependent protein catabolic process|protein targeting to lysosome|lysosomal transport|neuromuscular junction development|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of macroautophagy|apicolateral plasma membrane|protein ubiquitination|sodium channel inhibitor activity|enzyme binding|protein domain specific binding|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|receptor internalization|beta-2 adrenergic receptor binding|receptor catabolic process|protein-containing complex|cellular response to UV|regulation of ion transmembrane transport|regulation of membrane potential|glucocorticoid receptor signaling pathway|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|dendritic spine|development involved in symbiotic interaction|positive regulation of protein catabolic process|viral budding|positive regulation of nucleocytoplasmic transport|perinuclear region of cytoplasm|regulation of dendrite morphogenesis|regulation of synapse organization|phosphoserine residue binding|phosphothreonine residue binding|progesterone receptor signaling pathway|response to calcium ion|ubiquitin protein ligase activity|extracellular exosome|RNA polymerase binding|proline-rich region binding|protein K63-linked ubiquitination|regulation of potassium ion transmembrane transporter activity|negative regulation of sodium ion transmembrane transporter activity "hsa04120,hsa04144,hsa04530,hsa05169" Ubiquitin mediated proteolysis|Endocytosis|Tight junction|Epstein-Barr virus infection NEDD4L 2879.035174 2902.77407 2855.296279 0.983643994 -0.023791833 0.941526666 1 12.64321175 12.97212981 23327 NEDD4 like E3 ubiquitin protein ligase "GO:0000122,GO:0000209,GO:0003254,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005771,GO:0005794,GO:0005829,GO:0005886,GO:0006511,GO:0006814,GO:0006883,GO:0007588,GO:0010038,GO:0015459,GO:0016567,GO:0017080,GO:0019058,GO:0019870,GO:0019871,GO:0030104,GO:0030154,GO:0031647,GO:0034220,GO:0034765,GO:0042176,GO:0042391,GO:0043161,GO:0044325,GO:0045732,GO:0045807,GO:0048814,GO:0060306,GO:0061630,GO:0070062,GO:0070936,GO:0086005,GO:1901016,GO:1901017,GO:1901380,GO:1902306,GO:1903861,GO:2000009,GO:2000650,GO:2001288" negative regulation of transcription by RNA polymerase II|protein polyubiquitination|regulation of membrane depolarization|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|multivesicular body|Golgi apparatus|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|sodium ion transport|cellular sodium ion homeostasis|excretion|response to metal ion|potassium channel regulator activity|protein ubiquitination|sodium channel regulator activity|viral life cycle|potassium channel inhibitor activity|sodium channel inhibitor activity|water homeostasis|cell differentiation|regulation of protein stability|ion transmembrane transport|regulation of ion transmembrane transport|regulation of protein catabolic process|regulation of membrane potential|proteasome-mediated ubiquitin-dependent protein catabolic process|ion channel binding|positive regulation of protein catabolic process|positive regulation of endocytosis|regulation of dendrite morphogenesis|regulation of membrane repolarization|ubiquitin protein ligase activity|extracellular exosome|protein K48-linked ubiquitination|ventricular cardiac muscle cell action potential|regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transport|negative regulation of sodium ion transmembrane transport|positive regulation of dendrite extension|negative regulation of protein localization to cell surface|negative regulation of sodium ion transmembrane transporter activity|positive regulation of caveolin-mediated endocytosis "hsa04120,hsa04144,hsa04530,hsa04960" Ubiquitin mediated proteolysis|Endocytosis|Tight junction|Aldosterone-regulated sodium reabsorption NEDD8 1212.990649 1154.004936 1271.976362 1.102227835 0.140422465 0.68220619 1 94.88032293 109.0846036 4738 NEDD8 ubiquitin like modifier "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006464,GO:0006508,GO:0006511,GO:0006879,GO:0008104,GO:0009653,GO:0014070,GO:0016567,GO:0016579,GO:0019941,GO:0030162,GO:0031386,GO:0031625,GO:0043687,GO:0045116,GO:0070062" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|cellular protein modification process|proteolysis|ubiquitin-dependent protein catabolic process|cellular iron ion homeostasis|protein localization|anatomical structure morphogenesis|response to organic cyclic compound|protein ubiquitination|protein deubiquitination|modification-dependent protein catabolic process|regulation of proteolysis|protein tag|ubiquitin protein ligase binding|post-translational protein modification|protein neddylation|extracellular exosome NEDD9 33.0333279 35.52345889 30.54319691 0.859803574 -0.217920988 0.848029541 1 0.23682215 0.212391678 4739 "neural precursor cell expressed, developmentally down-regulated 9" "GO:0000922,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005819,GO:0005829,GO:0005886,GO:0005925,GO:0005938,GO:0007010,GO:0007049,GO:0007155,GO:0007165,GO:0007169,GO:0007229,GO:0016477,GO:0030027,GO:0030335,GO:0040008,GO:0051017,GO:0051301,GO:0061098,GO:0090527,GO:0090630,GO:1900026,GO:1990782" spindle pole|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|spindle|cytosol|plasma membrane|focal adhesion|cell cortex|cytoskeleton organization|cell cycle|cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|integrin-mediated signaling pathway|cell migration|lamellipodium|positive regulation of cell migration|regulation of growth|actin filament bundle assembly|cell division|positive regulation of protein tyrosine kinase activity|actin filament reorganization|activation of GTPase activity|positive regulation of substrate adhesion-dependent cell spreading|protein tyrosine kinase binding NEGR1 253.5826156 227.3501369 279.8150943 1.230767213 0.299557916 0.551183478 1 0.70967534 0.911069614 257194 neuronal growth regulator 1 "GO:0005515,GO:0005576,GO:0005886,GO:0007626,GO:0007631,GO:0010976,GO:0031225,GO:0098609" protein binding|extracellular region|plasma membrane|locomotory behavior|feeding behavior|positive regulation of neuron projection development|anchored component of membrane|cell-cell adhesion hsa04514 Cell adhesion molecules NEIL1 202.7848367 189.7967661 215.7729072 1.136862928 0.185058318 0.736445429 1 2.818099279 3.341798989 79661 nei like DNA glycosylase 1 "GO:0003684,GO:0003906,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005815,GO:0006284,GO:0006979,GO:0008022,GO:0008270,GO:0016798,GO:0019104,GO:0032074,GO:0045008,GO:0140078" "damaged DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|nucleus|nucleoplasm|chromosome|cytoplasm|microtubule organizing center|base-excision repair|response to oxidative stress|protein C-terminus binding|zinc ion binding|hydrolase activity, acting on glycosyl bonds|DNA N-glycosylase activity|negative regulation of nuclease activity|depyrimidination|class I DNA-(apurinic or apyrimidinic site) endonuclease activity" hsa03410 Base excision repair NEIL2 144.8647985 170.5126027 119.2169944 0.699168229 -0.516288467 0.390702363 1 3.727173843 2.718174065 252969 nei like DNA glycosylase 2 "GO:0003684,GO:0003906,GO:0005515,GO:0005654,GO:0005737,GO:0006284,GO:0008017,GO:0008270,GO:0019104,GO:0043231,GO:0045008,GO:0072686,GO:0140078" damaged DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|protein binding|nucleoplasm|cytoplasm|base-excision repair|microtubule binding|zinc ion binding|DNA N-glycosylase activity|intracellular membrane-bounded organelle|depyrimidination|mitotic spindle|class I DNA-(apurinic or apyrimidinic site) endonuclease activity hsa03410 Base excision repair NEIL3 349.640453 294.3372308 404.9436752 1.375781358 0.460251212 0.308101849 1 6.300567363 9.04159416 55247 nei like DNA glycosylase 3 "GO:0000405,GO:0003684,GO:0003690,GO:0003697,GO:0003906,GO:0005634,GO:0005654,GO:0005694,GO:0006284,GO:0008270,GO:0019104,GO:0036297,GO:0140078,GO:1904931" bubble DNA binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|nucleus|nucleoplasm|chromosome|base-excision repair|zinc ion binding|DNA N-glycosylase activity|interstrand cross-link repair|class I DNA-(apurinic or apyrimidinic site) endonuclease activity|MCM complex binding hsa03410 Base excision repair NEK1 360.5916846 369.4439725 351.7393967 0.952077779 -0.070848657 0.879873215 1 2.011290324 1.997391158 4750 NIMA related kinase 1 "GO:0000242,GO:0004672,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0007049,GO:0016301,GO:0018108,GO:0034451,GO:0042769,GO:0046872,GO:0051301,GO:0060271,GO:0071889,GO:0106310,GO:0106311" "pericentriolar material|protein kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|cell cycle|kinase activity|peptidyl-tyrosine phosphorylation|centriolar satellite|DNA damage response, detection of DNA damage|metal ion binding|cell division|cilium assembly|14-3-3 protein binding|protein serine kinase activity|protein threonine kinase activity" NEK10 37.98934154 37.55337083 38.42531225 1.023218726 0.033114572 1 1 0.099708821 0.10641871 152110 NIMA related kinase 10 "GO:0004672,GO:0004674,GO:0005524,GO:0005576,GO:0006468,GO:0031954,GO:0043406,GO:0046872,GO:0070372,GO:0106310,GO:0106311,GO:0120197,GO:1902749,GO:1902911" protein kinase activity|protein serine/threonine kinase activity|ATP binding|extracellular region|protein phosphorylation|positive regulation of protein autophosphorylation|positive regulation of MAP kinase activity|metal ion binding|regulation of ERK1 and ERK2 cascade|protein serine kinase activity|protein threonine kinase activity|mucociliary clearance|regulation of cell cycle G2/M phase transition|protein kinase complex NEK11 81.99419001 82.21143344 81.77694657 0.994715007 -0.007644853 1 1 0.663012592 0.68791753 79858 NIMA related kinase 11 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0006468,GO:0007059,GO:0016572,GO:0031573,GO:0035556,GO:0046872,GO:0106310,GO:0106311,GO:1901990" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|protein phosphorylation|chromosome segregation|histone phosphorylation|intra-S DNA damage checkpoint|intracellular signal transduction|metal ion binding|protein serine kinase activity|protein threonine kinase activity|regulation of mitotic cell cycle phase transition NEK2 770.3305454 697.2747503 843.3863406 1.209546653 0.274466416 0.459155756 1 10.76661776 13.58369272 4751 NIMA related kinase 2 "GO:0000070,GO:0000086,GO:0000278,GO:0000776,GO:0000777,GO:0000794,GO:0000922,GO:0001824,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0006468,GO:0007059,GO:0007088,GO:0010389,GO:0019903,GO:0030496,GO:0032212,GO:0032991,GO:0043392,GO:0046602,GO:0046777,GO:0046872,GO:0051225,GO:0051299,GO:0051301,GO:0051321,GO:0051973,GO:0051988,GO:0090307,GO:0097711,GO:0106310,GO:0106311,GO:1903126,GO:1904355" mitotic sister chromatid segregation|G2/M transition of mitotic cell cycle|mitotic cell cycle|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome|spindle pole|blastocyst development|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|microtubule|protein phosphorylation|chromosome segregation|regulation of mitotic nuclear division|regulation of G2/M transition of mitotic cell cycle|protein phosphatase binding|midbody|positive regulation of telomere maintenance via telomerase|protein-containing complex|negative regulation of DNA binding|regulation of mitotic centrosome separation|protein autophosphorylation|metal ion binding|spindle assembly|centrosome separation|cell division|meiotic cell cycle|positive regulation of telomerase activity|regulation of attachment of spindle microtubules to kinetochore|mitotic spindle assembly|ciliary basal body-plasma membrane docking|protein serine kinase activity|protein threonine kinase activity|negative regulation of centriole-centriole cohesion|positive regulation of telomere capping NEK3 180.9929749 148.1835714 213.8023784 1.442821066 0.528892392 0.343413753 1 3.145421262 4.733770756 4752 NIMA related kinase 3 "GO:0000278,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0030424,GO:0046872,GO:0051301,GO:0106310,GO:0106311" mitotic cell cycle|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|axon|metal ion binding|cell division|protein serine kinase activity|protein threonine kinase activity NEK4 768.4139565 768.3216681 768.5062449 1.000240234 0.000346543 1 1 4.487175047 4.681588756 6787 NIMA related kinase 4 "GO:0000278,GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006974,GO:0030145,GO:0035253,GO:0035869,GO:0036064,GO:0045893,GO:0051301,GO:0097014,GO:0106310,GO:0106311,GO:2000772,GO:2001020" "mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|cellular response to DNA damage stimulus|manganese ion binding|ciliary rootlet|ciliary transition zone|ciliary basal body|positive regulation of transcription, DNA-templated|cell division|ciliary plasm|protein serine kinase activity|protein threonine kinase activity|regulation of cellular senescence|regulation of response to DNA damage stimulus" NEK5 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.018519493 0.00625071 341676 NIMA related kinase 5 "GO:0005524,GO:0006468,GO:0046872,GO:0106310,GO:0106311" ATP binding|protein phosphorylation|metal ion binding|protein serine kinase activity|protein threonine kinase activity NEK6 1199.880844 1739.63453 660.1271591 0.379463127 -1.39796839 5.86E-05 0.010312872 19.71059326 7.801627446 10783 NIMA related kinase 6 "GO:0000287,GO:0000922,GO:0001222,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0006468,GO:0006915,GO:0007059,GO:0007077,GO:0007346,GO:0016607,GO:0018105,GO:0019894,GO:0019901,GO:0030071,GO:0031625,GO:0032991,GO:0033613,GO:0034451,GO:0043123,GO:0046777,GO:0051225,GO:0051301,GO:0106310,GO:0106311,GO:2000772" magnesium ion binding|spindle pole|transcription corepressor binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|microtubule|protein phosphorylation|apoptotic process|chromosome segregation|mitotic nuclear envelope disassembly|regulation of mitotic cell cycle|nuclear speck|peptidyl-serine phosphorylation|kinesin binding|protein kinase binding|regulation of mitotic metaphase/anaphase transition|ubiquitin protein ligase binding|protein-containing complex|activating transcription factor binding|centriolar satellite|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein autophosphorylation|spindle assembly|cell division|protein serine kinase activity|protein threonine kinase activity|regulation of cellular senescence NEK7 1479.86221 1346.84657 1612.87785 1.197521593 0.26005167 0.433887147 1 13.98381045 17.46726107 140609 NIMA related kinase 7 "GO:0000922,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005815,GO:0005874,GO:0006468,GO:0007346,GO:0032212,GO:0046872,GO:0051225,GO:0051973,GO:0106310,GO:0106311,GO:1904355" spindle pole|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|microtubule organizing center|microtubule|protein phosphorylation|regulation of mitotic cell cycle|positive regulation of telomere maintenance via telomerase|metal ion binding|spindle assembly|positive regulation of telomerase activity|protein serine kinase activity|protein threonine kinase activity|positive regulation of telomere capping hsa04621 NOD-like receptor signaling pathway NEK8 80.15727316 91.34603715 68.96850916 0.755024644 -0.405404361 0.585291855 1 1.294809553 1.01972473 284086 NIMA related kinase 8 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005929,GO:0006468,GO:0007059,GO:0007368,GO:0007507,GO:0009887,GO:0035330,GO:0046872,GO:0097543,GO:0097546,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cilium|protein phosphorylation|chromosome segregation|determination of left/right symmetry|heart development|animal organ morphogenesis|regulation of hippo signaling|metal ion binding|ciliary inversin compartment|ciliary base|protein serine kinase activity|protein threonine kinase activity NEK9 2369.174693 2364.847406 2373.501979 1.003659675 0.005270157 0.988329019 1 13.5441794 14.17931017 91754 NIMA related kinase 9 "GO:0005515,GO:0005524,GO:0005634,GO:0005813,GO:0005829,GO:0006468,GO:0007077,GO:0019901,GO:0046872,GO:0051301,GO:0106310,GO:0106311" protein binding|ATP binding|nucleus|centrosome|cytosol|protein phosphorylation|mitotic nuclear envelope disassembly|protein kinase binding|metal ion binding|cell division|protein serine kinase activity|protein threonine kinase activity NELFA 510.905129 541.9864871 479.8237709 0.885305782 -0.175752251 0.668026797 1 10.19676952 9.416116726 7469 negative elongation factor complex member A "GO:0005515,GO:0005654,GO:0005829,GO:0006366,GO:0006368,GO:0007275,GO:0016604,GO:0032021,GO:0034244,GO:0050434" protein binding|nucleoplasm|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|multicellular organism development|nuclear body|NELF complex|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of viral transcription NELFB 2363.6006 2253.20225 2473.99895 1.097992402 0.134868071 0.673571908 1 44.92785241 51.45539589 25920 negative elongation factor complex member B "GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0006366,GO:0006368,GO:0008283,GO:0032021,GO:0034244,GO:0048863,GO:0050434,GO:2000737" RNA binding|protein binding|nucleoplasm|cytoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|cell population proliferation|NELF complex|negative regulation of transcription elongation from RNA polymerase II promoter|stem cell differentiation|positive regulation of viral transcription|negative regulation of stem cell differentiation NELFCD 2992.58059 3255.978747 2729.182434 0.838206465 -0.254622447 0.423659869 1 73.71651189 64.45130464 51497 negative elongation factor complex member C/D "GO:0003723,GO:0005515,GO:0005654,GO:0006366,GO:0006368,GO:0016020,GO:0032021,GO:0034244,GO:0050434" RNA binding|protein binding|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|membrane|NELF complex|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of viral transcription NELFE 1461.872351 1363.085866 1560.658836 1.144945359 0.195278749 0.557762044 1 46.20849425 55.18518562 7936 negative elongation factor complex member E "GO:0000122,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006366,GO:0006368,GO:0016604,GO:0032021,GO:0034244,GO:0045944,GO:0050434,GO:0051571,GO:0070374,GO:1900364" negative regulation of transcription by RNA polymerase II|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|plasma membrane|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|nuclear body|NELF complex|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription by RNA polymerase II|positive regulation of viral transcription|positive regulation of histone H3-K4 methylation|positive regulation of ERK1 and ERK2 cascade|negative regulation of mRNA polyadenylation NELL2 106.8484871 97.43577296 116.2612012 1.193208589 0.254846267 0.709657865 1 1.129239855 1.405460027 4753 neural EGFL like 2 "GO:0005080,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0008201,GO:0070050" protein kinase C binding|calcium ion binding|protein binding|extracellular region|cytoplasm|heparin binding|neuron cellular homeostasis NEMF 1051.821729 1013.941012 1089.702445 1.074719763 0.103960521 0.767952674 1 8.468426007 9.493226923 9147 nuclear export mediator factor "GO:0000049,GO:0005634,GO:0043023,GO:0051168,GO:0072344,GO:1990112,GO:1990116" tRNA binding|nucleus|ribosomal large subunit binding|nuclear export|rescue of stalled ribosome|RQC complex|ribosome-associated ubiquitin-dependent protein catabolic process NEMP1 2089.980892 1700.051247 2479.910536 1.45872693 0.54470984 0.090506699 1 12.6230169 19.20671508 23306 nuclear envelope integral membrane protein 1 "GO:0003674,GO:0005635,GO:0005637,GO:0016021,GO:0071763" molecular_function|nuclear envelope|nuclear inner membrane|integral component of membrane|nuclear membrane organization NEMP2 352.9228533 316.6662621 389.1794445 1.22898929 0.297472343 0.510299214 1 1.764747914 2.262281818 100131211 nuclear envelope integral membrane protein 2 "GO:0005635,GO:0005637,GO:0016021" nuclear envelope|nuclear inner membrane|integral component of membrane NENF 989.4464738 892.1462962 1086.746651 1.218126059 0.284663439 0.420478599 1 49.32757926 62.675523 29937 neudesin neurotrophic factor "GO:0005515,GO:0005615,GO:0005739,GO:0005783,GO:0007165,GO:0008083,GO:0012505,GO:0016020,GO:0032099,GO:0043410,GO:0046872,GO:1901215" protein binding|extracellular space|mitochondrion|endoplasmic reticulum|signal transduction|growth factor activity|endomembrane system|membrane|negative regulation of appetite|positive regulation of MAPK cascade|metal ion binding|negative regulation of neuron death NEO1 2809.261034 2712.977303 2905.544764 1.070980122 0.098931704 0.756682826 1 24.15659803 26.98566425 4756 neogenin 1 "GO:0005515,GO:0005654,GO:0005794,GO:0005886,GO:0005887,GO:0007155,GO:0007411,GO:0030513,GO:0038023,GO:0039706,GO:0055072,GO:0098797" protein binding|nucleoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell adhesion|axon guidance|positive regulation of BMP signaling pathway|signaling receptor activity|co-receptor binding|iron ion homeostasis|plasma membrane protein complex "hsa04350,hsa04360,hsa04514" TGF-beta signaling pathway|Axon guidance|Cell adhesion molecules NEPRO 1094.229914 1050.479427 1137.980401 1.083296228 0.115427803 0.741187978 1 10.85777084 12.2688493 25871 nucleolus and neural progenitor protein "GO:0005634,GO:0005730,GO:0007275,GO:0045665,GO:0045747" nucleus|nucleolus|multicellular organism development|negative regulation of neuron differentiation|positive regulation of Notch signaling pathway NES 188.6321146 198.9313698 178.3328594 0.896454187 -0.157698238 0.781399428 1 1.809477747 1.69198799 10763 nestin "GO:0000086,GO:0003674,GO:0005515,GO:0005737,GO:0005882,GO:0007417,GO:0007420,GO:0019215,GO:0030844,GO:0031076,GO:0031730,GO:0032091,GO:0043086,GO:0043524,GO:0045111,GO:0048858,GO:0072089,GO:2000179" G2/M transition of mitotic cell cycle|molecular_function|protein binding|cytoplasm|intermediate filament|central nervous system development|brain development|intermediate filament binding|positive regulation of intermediate filament depolymerization|embryonic camera-type eye development|CCR5 chemokine receptor binding|negative regulation of protein binding|negative regulation of catalytic activity|negative regulation of neuron apoptotic process|intermediate filament cytoskeleton|cell projection morphogenesis|stem cell proliferation|positive regulation of neural precursor cell proliferation NET1 2896.115482 2689.633316 3102.597648 1.153539268 0.206067117 0.517534378 1 19.20491175 23.10790794 10276 neuroepithelial cell transforming 1 "GO:0001558,GO:0005515,GO:0005634,GO:0005829,GO:0007165,GO:0007186,GO:0035025,GO:0035556,GO:0043065,GO:0043547,GO:0051056,GO:0051451,GO:0070301,GO:0071479" regulation of cell growth|protein binding|nucleus|cytosol|signal transduction|G protein-coupled receptor signaling pathway|positive regulation of Rho protein signal transduction|intracellular signal transduction|positive regulation of apoptotic process|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|myoblast migration|cellular response to hydrogen peroxide|cellular response to ionizing radiation NETO1 473.5704854 347.1149412 600.0260297 1.728609053 0.789611622 0.057328078 1 1.337198389 2.411062995 81832 neuropilin and tolloid like 1 "GO:0005576,GO:0007613,GO:0008542,GO:0014069,GO:0035255,GO:0048169,GO:0060076,GO:0097120,GO:0098839,GO:0098978,GO:0099061,GO:2000312,GO:2000463" extracellular region|memory|visual learning|postsynaptic density|ionotropic glutamate receptor binding|regulation of long-term neuronal synaptic plasticity|excitatory synapse|receptor localization to synapse|postsynaptic density membrane|glutamatergic synapse|integral component of postsynaptic density membrane|regulation of kainate selective glutamate receptor activity|positive regulation of excitatory postsynaptic potential NETO2 783.1550664 866.772397 699.5377357 0.807060467 -0.309251326 0.402365589 1 5.698943803 4.797515414 81831 neuropilin and tolloid like 2 "GO:0014069,GO:0016021,GO:0035255,GO:2000312" postsynaptic density|integral component of membrane|ionotropic glutamate receptor binding|regulation of kainate selective glutamate receptor activity NEU1 715.683259 1002.776497 428.5900212 0.427403337 -1.226329922 0.001262468 0.105626513 15.1467617 6.752640535 4758 neuraminidase 1 "GO:0004308,GO:0005515,GO:0005576,GO:0005737,GO:0005764,GO:0005765,GO:0005886,GO:0006687,GO:0006689,GO:0009313,GO:0016020,GO:0016997,GO:0030054,GO:0035580,GO:0043202,GO:0043231,GO:0043312,GO:0052794,GO:0052795,GO:0052796,GO:0070062" exo-alpha-sialidase activity|protein binding|extracellular region|cytoplasm|lysosome|lysosomal membrane|plasma membrane|glycosphingolipid metabolic process|ganglioside catabolic process|oligosaccharide catabolic process|membrane|alpha-sialidase activity|cell junction|specific granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|exo-alpha-(2->3)-sialidase activity|exo-alpha-(2->6)-sialidase activity|exo-alpha-(2->8)-sialidase activity|extracellular exosome "hsa00511,hsa00600,hsa04142" Other glycan degradation|Sphingolipid metabolism|Lysosome NEU3 483.5161636 488.1938208 478.8385064 0.980836885 -0.027914861 0.951346202 1 3.731556713 3.817708506 10825 neuraminidase 3 "GO:0004308,GO:0005515,GO:0005737,GO:0005765,GO:0005886,GO:0005901,GO:0005975,GO:0006687,GO:0006689,GO:0009313,GO:0009897,GO:0016020,GO:0016997,GO:0031901,GO:0043231,GO:0045742,GO:0052794,GO:0052795,GO:0052796,GO:0055038,GO:1900186" exo-alpha-sialidase activity|protein binding|cytoplasm|lysosomal membrane|plasma membrane|caveola|carbohydrate metabolic process|glycosphingolipid metabolic process|ganglioside catabolic process|oligosaccharide catabolic process|external side of plasma membrane|membrane|alpha-sialidase activity|early endosome membrane|intracellular membrane-bounded organelle|positive regulation of epidermal growth factor receptor signaling pathway|exo-alpha-(2->3)-sialidase activity|exo-alpha-(2->6)-sialidase activity|exo-alpha-(2->8)-sialidase activity|recycling endosome membrane|negative regulation of clathrin-dependent endocytosis "hsa00511,hsa00600" Other glycan degradation|Sphingolipid metabolism NEURL1 52.70892468 33.49354696 71.92430241 2.147407753 1.102596158 0.18860847 1 0.227329134 0.509196656 9148 neuralized E3 ubiquitin protein ligase 1 "GO:0004842,GO:0005886,GO:0006417,GO:0006513,GO:0007219,GO:0007288,GO:0007399,GO:0007420,GO:0007519,GO:0007595,GO:0008285,GO:0014069,GO:0043065,GO:0043197,GO:0043204,GO:0045183,GO:0045741,GO:0045746,GO:0046872,GO:0048170,GO:0048471,GO:0051491,GO:0060999,GO:0061630,GO:0071230,GO:0090129,GO:0097440" "ubiquitin-protein transferase activity|plasma membrane|regulation of translation|protein monoubiquitination|Notch signaling pathway|sperm axoneme assembly|nervous system development|brain development|skeletal muscle tissue development|lactation|negative regulation of cell population proliferation|postsynaptic density|positive regulation of apoptotic process|dendritic spine|perikaryon|translation factor activity, non-nucleic acid binding|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of Notch signaling pathway|metal ion binding|positive regulation of long-term neuronal synaptic plasticity|perinuclear region of cytoplasm|positive regulation of filopodium assembly|positive regulation of dendritic spine development|ubiquitin protein ligase activity|cellular response to amino acid stimulus|positive regulation of synapse maturation|apical dendrite" NEURL1B 589.9086371 318.6961741 861.1211001 2.70201267 1.434034439 0.000330021 0.041898412 2.511410755 7.078171165 54492 neuralized E3 ubiquitin protein ligase 1B "GO:0005515,GO:0005769,GO:0005829,GO:0007219,GO:0015629,GO:0016567,GO:0046872,GO:0061630,GO:0070086" protein binding|early endosome|cytosol|Notch signaling pathway|actin cytoskeleton|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity|ubiquitin-dependent endocytosis NEURL2 15.47943932 14.20938356 16.74949508 1.178762964 0.237273638 0.895884728 1 0.593285366 0.729467669 140825 neuralized E3 ubiquitin protein ligase 2 "GO:0005829,GO:0016567,GO:0035556,GO:0043687,GO:0061630" cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification|ubiquitin protein ligase activity NEURL3 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.09842784 0.024916067 93082 neuralized E3 ubiquitin protein ligase 3 "GO:0016567,GO:0046872,GO:0061630" protein ubiquitination|metal ion binding|ubiquitin protein ligase activity NEURL4 980.506103 1055.554207 905.4579988 0.85780341 -0.221281043 0.532266109 1 10.26696693 9.186410783 84461 neuralized E3 ubiquitin protein ligase 4 "GO:0005515,GO:0005737,GO:0005814,GO:0016567,GO:0061630" protein binding|cytoplasm|centriole|protein ubiquitination|ubiquitin protein ligase activity NEUROG2 6.448756035 3.044867905 9.852644165 3.235819902 1.694131313 0.337064529 1 0.067194692 0.22679592 63973 neurogenin 2 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0030182,GO:0046983,GO:0051091,GO:0070888,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|neuron differentiation|protein dimerization activity|positive regulation of DNA-binding transcription factor activity|E-box binding|sequence-specific double-stranded DNA binding" bHLH NEXN 167.7985473 121.7947162 213.8023784 1.755432297 0.811826356 0.155823358 1 0.759103213 1.389955332 91624 nexilin F-actin binding protein "GO:0005886,GO:0005912,GO:0005925,GO:0007156,GO:0007411,GO:0008307,GO:0015629,GO:0030018,GO:0030334,GO:0030424,GO:0051015,GO:0051493,GO:0070593,GO:0098632" plasma membrane|adherens junction|focal adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|structural constituent of muscle|actin cytoskeleton|Z disc|regulation of cell migration|axon|actin filament binding|regulation of cytoskeleton organization|dendrite self-avoidance|cell-cell adhesion mediator activity NF1 6009.493646 5784.234064 6234.753228 1.077887437 0.108206526 0.738942488 1 22.09617211 24.8431341 4763 neurofibromin 1 "GO:0000165,GO:0001649,GO:0001656,GO:0001666,GO:0001889,GO:0001937,GO:0001952,GO:0005096,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006469,GO:0007154,GO:0007265,GO:0007406,GO:0007420,GO:0007422,GO:0007507,GO:0008429,GO:0008542,GO:0014044,GO:0014065,GO:0016020,GO:0021510,GO:0021897,GO:0021987,GO:0022011,GO:0030036,GO:0030198,GO:0030199,GO:0030325,GO:0030336,GO:0030424,GO:0030425,GO:0031210,GO:0042060,GO:0043065,GO:0043087,GO:0043407,GO:0043409,GO:0043473,GO:0043525,GO:0043535,GO:0043547,GO:0045124,GO:0045685,GO:0045762,GO:0045765,GO:0048147,GO:0048485,GO:0048593,GO:0048715,GO:0048745,GO:0048844,GO:0048853,GO:0050890" MAPK cascade|osteoblast differentiation|metanephros development|response to hypoxia|liver development|negative regulation of endothelial cell proliferation|regulation of cell-matrix adhesion|GTPase activator activity|protein binding|nucleus|nucleolus|cytoplasm|cytosol|negative regulation of protein kinase activity|cell communication|Ras protein signal transduction|negative regulation of neuroblast proliferation|brain development|peripheral nervous system development|heart development|phosphatidylethanolamine binding|visual learning|Schwann cell development|phosphatidylinositol 3-kinase signaling|membrane|spinal cord development|forebrain astrocyte development|cerebral cortex development|myelination in peripheral nervous system|actin cytoskeleton organization|extracellular matrix organization|collagen fibril organization|adrenal gland development|negative regulation of cell migration|axon|dendrite|phosphatidylcholine binding|wound healing|positive regulation of apoptotic process|regulation of GTPase activity|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|pigmentation|positive regulation of neuron apoptotic process|regulation of blood vessel endothelial cell migration|positive regulation of GTPase activity|regulation of bone resorption|regulation of glial cell differentiation|positive regulation of adenylate cyclase activity|regulation of angiogenesis|negative regulation of fibroblast proliferation|sympathetic nervous system development|camera-type eye morphogenesis|negative regulation of oligodendrocyte differentiation|smooth muscle tissue development|artery morphogenesis|forebrain morphogenesis|cognition "hsa01521,hsa04010,hsa04014" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway NF2 2307.749568 2308.009872 2307.489264 0.999774434 -0.00032546 1 1 17.53300703 18.28413265 4771 neurofibromin 2 "GO:0001707,GO:0001953,GO:0003779,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0006469,GO:0007398,GO:0008285,GO:0014010,GO:0014013,GO:0016020,GO:0021766,GO:0022408,GO:0030027,GO:0030036,GO:0030336,GO:0030864,GO:0031527,GO:0031647,GO:0032154,GO:0032587,GO:0035330,GO:0042475,GO:0042532,GO:0042981,GO:0043005,GO:0043409,GO:0044297,GO:0045177,GO:0045216,GO:0045597,GO:0046426,GO:0048471,GO:0051496,GO:0051726,GO:0070306,GO:0072091,GO:1900180,GO:2000177" mesoderm formation|negative regulation of cell-matrix adhesion|actin binding|protein binding|nucleus|nucleolus|cytoplasm|early endosome|cytosol|cytoskeleton|plasma membrane|adherens junction|negative regulation of protein kinase activity|ectoderm development|negative regulation of cell population proliferation|Schwann cell proliferation|regulation of gliogenesis|membrane|hippocampus development|negative regulation of cell-cell adhesion|lamellipodium|actin cytoskeleton organization|negative regulation of cell migration|cortical actin cytoskeleton|filopodium membrane|regulation of protein stability|cleavage furrow|ruffle membrane|regulation of hippo signaling|odontogenesis of dentin-containing tooth|negative regulation of tyrosine phosphorylation of STAT protein|regulation of apoptotic process|neuron projection|negative regulation of MAPK cascade|cell body|apical part of cell|cell-cell junction organization|positive regulation of cell differentiation|negative regulation of receptor signaling pathway via JAK-STAT|perinuclear region of cytoplasm|positive regulation of stress fiber assembly|regulation of cell cycle|lens fiber cell differentiation|regulation of stem cell proliferation|regulation of protein localization to nucleus|regulation of neural precursor cell proliferation "hsa04390,hsa04392,hsa04530" Hippo signaling pathway|Hippo signaling pathway - multiple species|Tight junction NFAT5 1210.02001 1152.98998 1267.05004 1.098925456 0.136093527 0.691680788 1 6.341065804 7.268527259 10725 nuclear factor of activated T cells 5 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001816,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0006366,GO:0006970,GO:0007165,GO:0007588,GO:0008134,GO:0033173,GO:0045944,GO:0070884,GO:0071345,GO:1901224,GO:1904996,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cytokine production|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|response to osmotic stress|signal transduction|excretion|transcription factor binding|calcineurin-NFAT signaling cascade|positive regulation of transcription by RNA polymerase II|regulation of calcineurin-NFAT signaling cascade|cellular response to cytokine stimulus|positive regulation of NIK/NF-kappaB signaling|positive regulation of leukocyte adhesion to vascular endothelial cell|sequence-specific double-stranded DNA binding" RHD NFATC1 22.49505644 22.3290313 22.66108158 1.014870787 0.021296056 1 1 0.151046703 0.159896122 4772 nuclear factor of activated T cells 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001225,GO:0001228,GO:0001816,GO:0003180,GO:0003184,GO:0003700,GO:0005515,GO:0005528,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0007223,GO:0008134,GO:0016604,GO:0030178,GO:0033173,GO:0035556,GO:0038095,GO:0045893,GO:0045944,GO:0048273,GO:1905064,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|cytokine production|aortic valve morphogenesis|pulmonary valve morphogenesis|DNA-binding transcription factor activity|protein binding|FK506 binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|Wnt signaling pathway, calcium modulating pathway|transcription factor binding|nuclear body|negative regulation of Wnt signaling pathway|calcineurin-NFAT signaling cascade|intracellular signal transduction|Fc-epsilon receptor signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|mitogen-activated protein kinase p38 binding|negative regulation of vascular associated smooth muscle cell differentiation|sequence-specific double-stranded DNA binding" "hsa04010,hsa04022,hsa04024,hsa04218,hsa04310,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04921,hsa04933,hsa05135,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235,hsa05321" MAPK signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cellular senescence|Wnt signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Oxytocin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Yersinia infection|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease RHD NFATC2 148.9812839 216.1856213 81.77694657 0.378271904 -1.40250447 0.019666272 0.604436841 1.142786667 0.450905134 4773 nuclear factor of activated T cells 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001816,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006974,GO:0008134,GO:0014904,GO:0016477,GO:0019902,GO:0030890,GO:0033173,GO:0038095,GO:0042493,GO:0045589,GO:0045893,GO:0045944,GO:0050853,GO:1901741,GO:1905064,GO:1990837,GO:1990904" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cytokine production|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|transcription factor binding|myotube cell development|cell migration|phosphatase binding|positive regulation of B cell proliferation|calcineurin-NFAT signaling cascade|Fc-epsilon receptor signaling pathway|response to drug|regulation of regulatory T cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|B cell receptor signaling pathway|positive regulation of myoblast fusion|negative regulation of vascular associated smooth muscle cell differentiation|sequence-specific double-stranded DNA binding|ribonucleoprotein complex" "hsa04022,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04921,hsa05135,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" cGMP-PKG signaling pathway|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Oxytocin signaling pathway|Yersinia infection|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer NFATC2IP 1496.969488 1169.229276 1824.709699 1.560608973 0.642109101 0.053342775 1 15.27401032 24.86354841 84901 nuclear factor of activated T cells 2 interacting protein "GO:0001816,GO:0005634,GO:0005737,GO:0045944" cytokine production|nucleus|cytoplasm|positive regulation of transcription by RNA polymerase II NFATC3 572.7486574 593.7492415 551.7480733 0.9292611 -0.105844079 0.792263836 1 4.611455982 4.469837705 4775 nuclear factor of activated T cells 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001816,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0006954,GO:0007275,GO:0008134,GO:0033173,GO:0038095,GO:0045944,GO:1902894,GO:1905064,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cytokine production|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|inflammatory response|multicellular organism development|transcription factor binding|calcineurin-NFAT signaling cascade|Fc-epsilon receptor signaling pathway|positive regulation of transcription by RNA polymerase II|negative regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of vascular associated smooth muscle cell differentiation|sequence-specific double-stranded DNA binding" "hsa04010,hsa04022,hsa04218,hsa04310,hsa04360,hsa04625,hsa04658,hsa04659,hsa04660,hsa04662,hsa04921,hsa05135,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" MAPK signaling pathway|cGMP-PKG signaling pathway|Cellular senescence|Wnt signaling pathway|Axon guidance|C-type lectin receptor signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Oxytocin signaling pathway|Yersinia infection|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer RHD NFATC4 908.4105783 774.4114039 1042.409753 1.346067152 0.428750384 0.231872048 1 7.199193401 10.10802941 4776 nuclear factor of activated T cells 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001569,GO:0001816,GO:0005515,GO:0005634,GO:0005667,GO:0005829,GO:0006357,GO:0006954,GO:0007507,GO:0007616,GO:0008134,GO:0008630,GO:0016607,GO:0030178,GO:0031547,GO:0032091,GO:0032760,GO:0033173,GO:0034644,GO:0035562,GO:0042975,GO:0043524,GO:0045333,GO:0045944,GO:0050774,GO:0051145,GO:0055001,GO:0060291,GO:0071285,GO:1902894,GO:1904637,GO:1990837,GO:2000297,GO:2001235" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|branching involved in blood vessel morphogenesis|cytokine production|protein binding|nucleus|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|inflammatory response|heart development|long-term memory|transcription factor binding|intrinsic apoptotic signaling pathway in response to DNA damage|nuclear speck|negative regulation of Wnt signaling pathway|brain-derived neurotrophic factor receptor signaling pathway|negative regulation of protein binding|positive regulation of tumor necrosis factor production|calcineurin-NFAT signaling cascade|cellular response to UV|negative regulation of chromatin binding|peroxisome proliferator activated receptor binding|negative regulation of neuron apoptotic process|cellular respiration|positive regulation of transcription by RNA polymerase II|negative regulation of dendrite morphogenesis|smooth muscle cell differentiation|muscle cell development|long-term synaptic potentiation|cellular response to lithium ion|negative regulation of pri-miRNA transcription by RNA polymerase II|cellular response to ionomycin|sequence-specific double-stranded DNA binding|negative regulation of synapse maturation|positive regulation of apoptotic signaling pathway" "hsa04022,hsa04218,hsa04310,hsa04360,hsa04625,hsa04921,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170" cGMP-PKG signaling pathway|Cellular senescence|Wnt signaling pathway|Axon guidance|C-type lectin receptor signaling pathway|Oxytocin signaling pathway|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection NFE2 10.49373413 10.14955968 10.83790858 1.067820568 0.094669242 1 1 0.256891251 0.286130085 4778 "nuclear factor, erythroid 2" "GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006337,GO:0006357,GO:0007275,GO:0007596,GO:0007599,GO:0016605,GO:0032993,GO:0043565,GO:0045652,GO:0045893,GO:0047485,GO:0050699,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|nucleosome disassembly|regulation of transcription by RNA polymerase II|multicellular organism development|blood coagulation|hemostasis|PML body|protein-DNA complex|sequence-specific DNA binding|regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|protein N-terminus binding|WW domain binding|sequence-specific double-stranded DNA binding" TF_bZIP NFE2L1 7679.666781 7613.184719 7746.148843 1.017464981 0.02497914 0.93997655 1 112.5455191 119.4437992 4779 "nuclear factor, erythroid 2 like 1" "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005789,GO:0005829,GO:0006357,GO:0006783,GO:0008203,GO:0008289,GO:0009653,GO:0016021,GO:0034599" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|endoplasmic reticulum membrane|cytosol|regulation of transcription by RNA polymerase II|heme biosynthetic process|cholesterol metabolic process|lipid binding|anatomical structure morphogenesis|integral component of membrane|cellular response to oxidative stress" NFE2L2 1966.722879 1827.935699 2105.510058 1.151851271 0.203954446 0.527682831 1 29.11273415 34.97802872 4780 "nuclear factor, erythroid 2 like 2" "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001102,GO:0001221,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005886,GO:0006357,GO:0006954,GO:0007568,GO:0010226,GO:0010499,GO:0010628,GO:0010667,GO:0010976,GO:0016032,GO:0016567,GO:0019904,GO:0030194,GO:0030968,GO:0032993,GO:0034599,GO:0035690,GO:0036003,GO:0036091,GO:0036499,GO:0042149,GO:0043161,GO:0043536,GO:0043565,GO:0045454,GO:0045766,GO:0045944,GO:0045995,GO:0046223,GO:0046326,GO:0061419,GO:0070301,GO:0071280,GO:0071356,GO:0071498,GO:0071499,GO:1902037,GO:1902176,GO:1903071,GO:1903206,GO:1903788,GO:1904385,GO:1904753,GO:2000121,GO:2000352,GO:2000379" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|transcription coregulator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|inflammatory response|aging|response to lithium ion|proteasomal ubiquitin-independent protein catabolic process|positive regulation of gene expression|negative regulation of cardiac muscle cell apoptotic process|positive regulation of neuron projection development|viral process|protein ubiquitination|protein domain specific binding|positive regulation of blood coagulation|endoplasmic reticulum unfolded protein response|protein-DNA complex|cellular response to oxidative stress|cellular response to drug|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|PERK-mediated unfolded protein response|cellular response to glucose starvation|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of blood vessel endothelial cell migration|sequence-specific DNA binding|cell redox homeostasis|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|regulation of embryonic development|aflatoxin catabolic process|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hydrogen peroxide|cellular response to copper ion|cellular response to tumor necrosis factor|cellular response to fluid shear stress|cellular response to laminar fluid shear stress|negative regulation of hematopoietic stem cell differentiation|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of hydrogen peroxide-induced cell death|positive regulation of glutathione biosynthetic process|cellular response to angiotensin|negative regulation of vascular associated smooth muscle cell migration|regulation of removal of superoxide radicals|negative regulation of endothelial cell apoptotic process|positive regulation of reactive oxygen species metabolic process" "hsa04141,hsa05012,hsa05200,hsa05225,hsa05418" Protein processing in endoplasmic reticulum|Parkinson disease|Pathways in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis TF_bZIP NFE2L3 776.521234 1120.511389 432.5310789 0.386012211 -1.373281608 0.000254293 0.034815072 15.17378314 6.109572826 9603 "nuclear factor, erythroid 2 like 3" "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0006366" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II" NFIA 191.600032 233.4398727 149.7601913 0.641536467 -0.640396819 0.241840235 1 1.117160165 0.747571472 4774 nuclear factor I A "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0006260,GO:0006355,GO:0006357,GO:0008134,GO:0019079,GO:0030054,GO:0045944,GO:0060074,GO:0072189" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|DNA replication|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription factor binding|viral genome replication|cell junction|positive regulation of transcription by RNA polymerase II|synapse maturation|ureter development" NFI NFIB 959.1111178 906.3556798 1011.866556 1.116412219 0.15886982 0.655946036 1 4.414667989 5.140892924 4781 nuclear factor I B "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0002062,GO:0003677,GO:0005634,GO:0005654,GO:0006260,GO:0006357,GO:0007420,GO:0010001,GO:0021740,GO:0021960,GO:0044300,GO:0045893,GO:0045944,GO:0060486,GO:0060509,GO:0060510,GO:0061141,GO:0071679,GO:1902894,GO:1990837,GO:2000791,GO:2000795" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|chondrocyte differentiation|DNA binding|nucleus|nucleoplasm|DNA replication|regulation of transcription by RNA polymerase II|brain development|glial cell differentiation|principal sensory nucleus of trigeminal nerve development|anterior commissure morphogenesis|cerebellar mossy fiber|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|club cell differentiation|type I pneumocyte differentiation|type II pneumocyte differentiation|lung ciliated cell differentiation|commissural neuron axon guidance|negative regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding|negative regulation of mesenchymal cell proliferation involved in lung development|negative regulation of epithelial cell proliferation involved in lung morphogenesis" NFIC 1969.777149 1902.027485 2037.526813 1.071239417 0.099280951 0.759301528 1 11.8868438 13.28216986 4782 nuclear factor I C "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0003700,GO:0005634,GO:0005654,GO:0006260,GO:0006357,GO:0006366,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|DNA-binding transcription factor activity|nucleus|nucleoplasm|DNA replication|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" NFI NFIL3 241.0656505 314.6363502 167.4949508 0.532344564 -0.90956775 0.073822782 1 5.472260016 3.038613609 4783 "nuclear factor, interleukin 3 regulated" "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006366,GO:0006955,GO:0007623,GO:0045892,GO:0045893,GO:0071353" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|transcription by RNA polymerase II|immune response|circadian rhythm|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|cellular response to interleukin-4" TF_bZIP NFIX 1199.770489 1260.575313 1138.965666 0.903528456 -0.146358057 0.669978683 1 9.530331773 8.981849716 4784 nuclear factor I X "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006260,GO:0006357,GO:0006366,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|DNA replication|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" NFKB1 2225.25854 2461.268223 1989.248857 0.808221078 -0.307178118 0.337596273 1 27.95571937 23.56767684 4790 nuclear factor kappa B subunit 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0002223,GO:0003682,GO:0003700,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006357,GO:0006366,GO:0006915,GO:0006954,GO:0008134,GO:0010629,GO:0010744,GO:0010884,GO:0010956,GO:0010957,GO:0031293,GO:0032269,GO:0032375,GO:0032481,GO:0032695,GO:0033256,GO:0034774,GO:0035580,GO:0035994,GO:0038095,GO:0042802,GO:0042805,GO:0043066,GO:0043312,GO:0045893,GO:0045944,GO:0050728,GO:0050852,GO:0051092,GO:0051403,GO:0070498,GO:0071222,GO:0071260,GO:0071316,GO:0071347,GO:0071354,GO:0071356,GO:0071359,GO:0090263,GO:1900127,GO:1904385,GO:2000630" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|stimulatory C-type lectin receptor signaling pathway|chromatin binding|DNA-binding transcription factor activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|apoptotic process|inflammatory response|transcription factor binding|negative regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of lipid storage|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of vitamin D biosynthetic process|membrane protein intracellular domain proteolysis|negative regulation of cellular protein metabolic process|negative regulation of cholesterol transport|positive regulation of type I interferon production|negative regulation of interleukin-12 production|I-kappaB/NF-kappaB complex|secretory granule lumen|specific granule lumen|response to muscle stretch|Fc-epsilon receptor signaling pathway|identical protein binding|actinin binding|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to nicotine|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to dsRNA|positive regulation of canonical Wnt signaling pathway|positive regulation of hyaluronan biosynthetic process|cellular response to angiotensin|positive regulation of miRNA metabolic process" "hsa01523,hsa04010,hsa04014,hsa04024,hsa04062,hsa04064,hsa04066,hsa04071,hsa04151,hsa04210,hsa04211,hsa04218,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04917,hsa04920,hsa04926,hsa04931,hsa04932,hsa04933,hsa05010,hsa05022,hsa05030,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05202,hsa05203,hsa05206,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05235,hsa05321,hsa05418" Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Cellular senescence|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease|Fluid shear stress and atherosclerosis RHD NFKB2 5557.452004 5224.993325 5889.910682 1.127257073 0.172816562 0.592630703 1 64.65367194 76.0207402 4791 nuclear factor kappa B subunit 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002268,GO:0002467,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0007568,GO:0030198,GO:0032481,GO:0032496,GO:0033257,GO:0034097,GO:0038061,GO:0045944,GO:0048511,GO:0048536,GO:0051092,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|follicular dendritic cell differentiation|germinal center formation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|aging|extracellular matrix organization|positive regulation of type I interferon production|response to lipopolysaccharide|Bcl3/NF-kappaB2 complex|response to cytokine|NIK/NF-kappaB signaling|positive regulation of transcription by RNA polymerase II|rhythmic process|spleen development|positive regulation of NF-kappaB transcription factor activity|sequence-specific double-stranded DNA binding" "hsa04010,hsa04064,hsa04380,hsa04625,hsa05134,hsa05166,hsa05169,hsa05200,hsa05203,hsa05224" MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Legionellosis|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Breast cancer RHD NFKBIA 4870.14545 4612.974876 5127.316024 1.111498797 0.152506386 0.634625164 1 149.8594637 173.7437139 4792 NFKB inhibitor alpha "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006606,GO:0006915,GO:0007249,GO:0007253,GO:0008134,GO:0008139,GO:0010745,GO:0010875,GO:0010888,GO:0016032,GO:0016579,GO:0019899,GO:0031625,GO:0031663,GO:0032088,GO:0032270,GO:0032495,GO:0033209,GO:0033256,GO:0034142,GO:0035994,GO:0042127,GO:0042802,GO:0042994,GO:0043066,GO:0043330,GO:0043392,GO:0045638,GO:0045746,GO:0045944,GO:0050729,GO:0051059,GO:0070417,GO:0070427,GO:0070431,GO:0070498,GO:1901222" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein import into nucleus|apoptotic process|I-kappaB kinase/NF-kappaB signaling|cytoplasmic sequestering of NF-kappaB|transcription factor binding|nuclear localization sequence binding|negative regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol efflux|negative regulation of lipid storage|viral process|protein deubiquitination|enzyme binding|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of cellular protein metabolic process|response to muramyl dipeptide|tumor necrosis factor-mediated signaling pathway|I-kappaB/NF-kappaB complex|toll-like receptor 4 signaling pathway|response to muscle stretch|regulation of cell population proliferation|identical protein binding|cytoplasmic sequestering of transcription factor|negative regulation of apoptotic process|response to exogenous dsRNA|negative regulation of DNA binding|negative regulation of myeloid cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|positive regulation of inflammatory response|NF-kappaB binding|cellular response to cold|nucleotide-binding oligomerization domain containing 1 signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|interleukin-1-mediated signaling pathway|regulation of NIK/NF-kappaB signaling "hsa04024,hsa04062,hsa04064,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04920,hsa04926,hsa04931,hsa05120,hsa05130,hsa05131,hsa05132,hsa05134,hsa05135,hsa05140,hsa05142,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05215,hsa05220,hsa05222,hsa05235" cAMP signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Insulin resistance|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Prostate cancer|Chronic myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer NFKBIB 295.0000936 330.8756457 259.1245416 0.783147823 -0.352643446 0.459812228 1 11.47786589 9.376069558 4793 NFKB inhibitor beta "GO:0003713,GO:0005515,GO:0005634,GO:0005829,GO:0006351,GO:0007165,GO:0007253,GO:0045893,GO:0071222" "transcription coactivator activity|protein binding|nucleus|cytosol|transcription, DNA-templated|signal transduction|cytoplasmic sequestering of NF-kappaB|positive regulation of transcription, DNA-templated|cellular response to lipopolysaccharide" "hsa04062,hsa04621,hsa04622,hsa04623,hsa04658,hsa04659,hsa04660,hsa04662,hsa04722,hsa04920,hsa05130,hsa05131,hsa05140,hsa05145,hsa05162,hsa05164,hsa05169,hsa05171,hsa05235" Chemokine signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Leishmaniasis|Toxoplasmosis|Measles|Influenza A|Epstein-Barr virus infection|Coronavirus disease - COVID-19|PD-L1 expression and PD-1 checkpoint pathway in cancer NFKBID 184.2874994 205.0211056 163.5538931 0.797741738 -0.326006333 0.559574365 1 2.927430428 2.435930131 84807 NFKB inhibitor delta "GO:0005515,GO:0005634,GO:0006954,GO:0010468,GO:0050852,GO:2000321" protein binding|nucleus|inflammatory response|regulation of gene expression|T cell receptor signaling pathway|positive regulation of T-helper 17 cell differentiation NFKBIE 213.1125456 222.2753571 203.9497342 0.91755441 -0.124134383 0.821531536 1 4.802671798 4.596536001 4794 NFKB inhibitor epsilon "GO:0001650,GO:0005515,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0042942,GO:0042994,GO:0048471" fibrillar center|protein binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|D-serine transport|cytoplasmic sequestering of transcription factor|perinuclear region of cytoplasm "hsa04658,hsa04659,hsa04660,hsa04662,hsa04722,hsa04920,hsa05169,hsa05235" Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Epstein-Barr virus infection|PD-L1 expression and PD-1 checkpoint pathway in cancer NFKBIL1 286.0490824 257.798816 314.2993489 1.219165215 0.285893646 0.554175366 1 8.539307109 10.85928236 4795 NFKB inhibitor like 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007249,GO:0031665,GO:0032088,GO:0032720,GO:0034122,GO:0071222" protein binding|nucleus|nucleoplasm|cytosol|I-kappaB kinase/NF-kappaB signaling|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|cellular response to lipopolysaccharide NFKBIZ 2631.775622 2939.312484 2324.238759 0.790742315 -0.338720465 0.288015714 1 35.49494708 29.27638452 64332 NFKB inhibitor zeta "GO:0005515,GO:0005634,GO:0006954,GO:0010468,GO:0016607,GO:0036464,GO:0050729,GO:0050852,GO:2000321" protein binding|nucleus|inflammatory response|regulation of gene expression|nuclear speck|cytoplasmic ribonucleoprotein granule|positive regulation of inflammatory response|T cell receptor signaling pathway|positive regulation of T-helper 17 cell differentiation hsa05202 Transcriptional misregulation in cancer NFRKB 723.2996342 782.5310516 664.0682168 0.848615803 -0.23681655 0.528873146 1 6.027747097 5.335585299 4798 nuclear factor related to kappaB binding protein "GO:0002020,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0016579,GO:0031011" protease binding|DNA binding|protein binding|nucleus|nucleoplasm|DNA repair|DNA recombination|protein deubiquitination|Ino80 complex NFS1 927.8295914 990.5970251 865.0621577 0.873273527 -0.195494489 0.585200573 1 16.67893773 15.19268774 9054 NFS1 cysteine desulfurase "GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006777,GO:0016226,GO:0018283,GO:0030170,GO:0031071,GO:0032324,GO:0042803,GO:0044281,GO:0044571,GO:0046872,GO:0051536" protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|Mo-molybdopterin cofactor biosynthetic process|iron-sulfur cluster assembly|iron incorporation into metallo-sulfur cluster|pyridoxal phosphate binding|cysteine desulfurase activity|molybdopterin cofactor biosynthetic process|protein homodimerization activity|small molecule metabolic process|[2Fe-2S] cluster assembly|metal ion binding|iron-sulfur cluster binding "hsa00730,hsa04122" Thiamine metabolism|Sulfur relay system NFU1 468.5172323 439.4759343 497.5585304 1.132163314 0.179082082 0.669268279 1 10.14027594 11.97497958 27247 NFU1 iron-sulfur cluster scaffold "GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0016226,GO:0051539,GO:0097428" "iron ion binding|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|iron-sulfur cluster assembly|4 iron, 4 sulfur cluster binding|protein maturation by iron-sulfur cluster transfer" NFX1 1505.971471 1717.305498 1294.637443 0.75387719 -0.407598574 0.218822268 1 15.3368833 12.060176 4799 "nuclear transcription factor, X-box binding 1" "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006355,GO:0006366,GO:0006954,GO:0008270,GO:0016032,GO:0016567,GO:0045347,GO:0051865,GO:0061630" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|regulation of transcription, DNA-templated|transcription by RNA polymerase II|inflammatory response|zinc ion binding|viral process|protein ubiquitination|negative regulation of MHC class II biosynthetic process|protein autoubiquitination|ubiquitin protein ligase activity" hsa05165 Human papillomavirus infection NFXL1 340.2601521 360.3093688 320.2109354 0.8887111 -0.170213588 0.712286009 1 4.629223347 4.291258423 152518 "nuclear transcription factor, X-box binding like 1" "GO:0000785,GO:0000977,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0008270,GO:0016020,GO:0016021" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|membrane|integral component of membrane" NFYA 939.2410421 1097.167402 781.3146823 0.712119847 -0.489808033 0.169421337 1 8.949534277 6.647670047 4800 nuclear transcription factor Y subunit alpha "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006366,GO:0016602,GO:0032993,GO:0045540,GO:0045893,GO:0048511,GO:0090575" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|CCAAT-binding factor complex|protein-DNA complex|regulation of cholesterol biosynthetic process|positive regulation of transcription, DNA-templated|rhythmic process|RNA polymerase II transcription regulator complex" "hsa04612,hsa05017,hsa05152" Antigen processing and presentation|Spinocerebellar ataxia|Tuberculosis NF-YA NFYB 633.102165 611.003493 655.200837 1.072335665 0.100756572 0.797351697 1 7.353890548 8.225529079 4801 nuclear transcription factor Y subunit beta "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0016602,GO:0032993,GO:0045540,GO:0045944,GO:0046982,GO:0070491,GO:0090575" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|CCAAT-binding factor complex|protein-DNA complex|regulation of cholesterol biosynthetic process|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|repressing transcription factor binding|RNA polymerase II transcription regulator complex" "hsa04612,hsa05152,hsa05166" Antigen processing and presentation|Tuberculosis|Human T-cell leukemia virus 1 infection NF-YB/C NFYC 968.0715315 1047.434559 888.7085037 0.848462079 -0.237077913 0.504227213 1 10.37935146 9.185833822 4802 nuclear transcription factor Y subunit gamma "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006457,GO:0008134,GO:0016602,GO:0032993,GO:0045540,GO:0045944,GO:0046982,GO:0090575" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|protein folding|transcription factor binding|CCAAT-binding factor complex|protein-DNA complex|regulation of cholesterol biosynthetic process|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|RNA polymerase II transcription regulator complex" "hsa04612,hsa05152" Antigen processing and presentation|Tuberculosis NF-YB/C NGDN 500.9540076 467.8947014 534.0133138 1.141310881 0.19069182 0.643035083 1 21.38737906 25.46111708 25983 neuroguidin "GO:0000462,GO:0000775,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0006417,GO:0030175,GO:0030424,GO:0030425,GO:0032040" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|chromosome, centromeric region|RNA binding|protein binding|nucleoplasm|nucleolus|mitochondrion|regulation of translation|filopodium|axon|dendrite|small-subunit processome" NGEF 23.52485819 25.37389921 21.67581716 0.854256454 -0.227258852 0.866817019 1 0.349401436 0.311335672 25791 neuronal guanine nucleotide exchange factor "GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0007399,GO:0016020,GO:0030154,GO:0030426,GO:0043065,GO:0043087,GO:0048013,GO:0051056,GO:0061002,GO:0090630" guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|nervous system development|membrane|cell differentiation|growth cone|positive regulation of apoptotic process|regulation of GTPase activity|ephrin receptor signaling pathway|regulation of small GTPase mediated signal transduction|negative regulation of dendritic spine morphogenesis|activation of GTPase activity hsa04360 Axon guidance NGF 33.84044301 23.34398727 44.33689874 1.899285594 0.925456859 0.336013728 1 0.285991921 0.566578342 4803 nerve growth factor "GO:0000186,GO:0005163,GO:0005515,GO:0005576,GO:0005615,GO:0005796,GO:0005829,GO:0006919,GO:0007169,GO:0007422,GO:0007613,GO:0008021,GO:0008083,GO:0008191,GO:0008285,GO:0008289,GO:0008625,GO:0010628,GO:0021675,GO:0030424,GO:0030425,GO:0031904,GO:0032455,GO:0033138,GO:0038180,GO:0043065,GO:0043066,GO:0043154,GO:0043281,GO:0043388,GO:0043524,GO:0045664,GO:0045666,GO:0046579,GO:0048011,GO:0048015,GO:0048672,GO:0048812,GO:0050772,GO:0050804" activation of MAPKK activity|nerve growth factor receptor binding|protein binding|extracellular region|extracellular space|Golgi lumen|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|transmembrane receptor protein tyrosine kinase signaling pathway|peripheral nervous system development|memory|synaptic vesicle|growth factor activity|metalloendopeptidase inhibitor activity|negative regulation of cell population proliferation|lipid binding|extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of gene expression|nerve development|axon|dendrite|endosome lumen|nerve growth factor processing|positive regulation of peptidyl-serine phosphorylation|nerve growth factor signaling pathway|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of DNA binding|negative regulation of neuron apoptotic process|regulation of neuron differentiation|positive regulation of neuron differentiation|positive regulation of Ras protein signal transduction|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of collateral sprouting|neuron projection morphogenesis|positive regulation of axonogenesis|modulation of chemical synaptic transmission "hsa04010,hsa04014,hsa04015,hsa04020,hsa04060,hsa04151,hsa04210,hsa04722,hsa04750" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Apoptosis|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels NGFR 21.1507718 31.46363502 10.83790858 0.344458248 -1.537598973 0.165734199 1 0.467582781 0.168000675 4804 nerve growth factor receptor "GO:0001540,GO:0001678,GO:0004888,GO:0005035,GO:0005515,GO:0005516,GO:0005576,GO:0005654,GO:0005768,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0006886,GO:0006919,GO:0007266,GO:0007411,GO:0007417,GO:0009986,GO:0014069,GO:0015026,GO:0016021,GO:0016048,GO:0021675,GO:0030426,GO:0031069,GO:0031267,GO:0031293,GO:0031625,GO:0032922,GO:0035907,GO:0038023,GO:0040037,GO:0042488,GO:0042593,GO:0043065,GO:0043066,GO:0043121,GO:0043154,GO:0043197,GO:0043204,GO:0043281,GO:0048011,GO:0048146,GO:0048406,GO:0050771,GO:0050772,GO:0051402,GO:0051799,GO:1900182,GO:1902895,GO:1903588,GO:1904646,GO:2001235" amyloid-beta binding|cellular glucose homeostasis|transmembrane signaling receptor activity|death receptor activity|protein binding|calmodulin binding|extracellular region|nucleoplasm|endosome|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|intracellular protein transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|Rho protein signal transduction|axon guidance|central nervous system development|cell surface|postsynaptic density|coreceptor activity|integral component of membrane|detection of temperature stimulus|nerve development|growth cone|hair follicle morphogenesis|small GTPase binding|membrane protein intracellular domain proteolysis|ubiquitin protein ligase binding|circadian regulation of gene expression|dorsal aorta development|signaling receptor activity|negative regulation of fibroblast growth factor receptor signaling pathway|positive regulation of odontogenesis of dentin-containing tooth|glucose homeostasis|positive regulation of apoptotic process|negative regulation of apoptotic process|neurotrophin binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|dendritic spine|perikaryon|regulation of cysteine-type endopeptidase activity involved in apoptotic process|neurotrophin TRK receptor signaling pathway|positive regulation of fibroblast proliferation|nerve growth factor binding|negative regulation of axonogenesis|positive regulation of axonogenesis|neuron apoptotic process|negative regulation of hair follicle development|positive regulation of protein localization to nucleus|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|cellular response to amyloid-beta|positive regulation of apoptotic signaling pathway "hsa04010,hsa04014,hsa04015,hsa04060,hsa04151,hsa04215,hsa04722,hsa05202" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Apoptosis - multiple species|Neurotrophin signaling pathway|Transcriptional misregulation in cancer NGLY1 629.6186048 675.9606749 583.2765346 0.862885307 -0.212759283 0.583745616 1 9.681850548 8.714197091 55768 N-glycanase 1 "GO:0000224,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006457,GO:0006515,GO:0006516,GO:0006517,GO:0046872" peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding|nucleus|cytoplasm|cytosol|protein folding|protein quality control for misfolded or incompletely synthesized proteins|glycoprotein catabolic process|protein deglycosylation|metal ion binding hsa04141 Protein processing in endoplasmic reticulum NGRN 2034.665545 1959.879975 2109.451116 1.07631648 0.10610235 0.742613719 1 74.07537813 83.16293283 51335 "neugrin, neurite outgrowth associated" "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0016604,GO:0019843,GO:0030182,GO:0031966,GO:0045171,GO:0070131,GO:0072686" RNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|nuclear body|rRNA binding|neuron differentiation|mitochondrial membrane|intercellular bridge|positive regulation of mitochondrial translation|mitotic spindle NHEJ1 462.7689494 450.64045 474.8974488 1.053827833 0.075639189 0.860674107 1 2.824322364 3.104558583 79840 non-homologous end joining factor 1 "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0006303,GO:0007417,GO:0010212,GO:0030183,GO:0030217,GO:0032807,GO:0045027,GO:0051351,GO:0070419" fibrillar center|protein binding|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|central nervous system development|response to ionizing radiation|B cell differentiation|T cell differentiation|DNA ligase IV complex|DNA end binding|positive regulation of ligase activity|nonhomologous end joining complex hsa03450 Non-homologous end-joining NHLRC1 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.068906085 0.116286112 378884 NHL repeat containing E3 ubiquitin protein ligase 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005783,GO:0005829,GO:0005978,GO:0006914,GO:0010468,GO:0031398,GO:0034976,GO:0043161,GO:0045859,GO:0046872,GO:0048471,GO:0061630,GO:1903076" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|endoplasmic reticulum|cytosol|glycogen biosynthetic process|autophagy|regulation of gene expression|positive regulation of protein ubiquitination|response to endoplasmic reticulum stress|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of protein kinase activity|metal ion binding|perinuclear region of cytoplasm|ubiquitin protein ligase activity|regulation of protein localization to plasma membrane hsa04120 Ubiquitin mediated proteolysis NHLRC2 883.2066636 836.3237179 930.0896092 1.112116743 0.153308241 0.67221733 1 3.817307673 4.428161729 374354 NHL repeat containing 2 "GO:0002576,GO:0005515,GO:0005576,GO:0005829,GO:0031093" platelet degranulation|protein binding|extracellular region|cytosol|platelet alpha granule lumen NHLRC3 381.611566 358.2794568 404.9436752 1.130245308 0.176635929 0.691350919 1 5.319727515 6.271595363 387921 NHL repeat containing 3 "GO:0000209,GO:0005576,GO:0035578,GO:0043161,GO:0043312,GO:0061630" protein polyubiquitination|extracellular region|azurophil granule lumen|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|ubiquitin protein ligase activity NHLRC4 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.073574341 0.148997129 283948 NHL repeat containing 4 "GO:0005515,GO:0061630,GO:0070936" protein binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination NHP2 1385.966413 1495.030141 1276.902684 0.854098288 -0.227525993 0.49743721 1 97.0743622 86.48251816 55651 NHP2 ribonucleoprotein "GO:0000469,GO:0000470,GO:0000781,GO:0003723,GO:0005515,GO:0005654,GO:0005697,GO:0005732,GO:0007004,GO:0031118,GO:0031120,GO:0031429,GO:0034513,GO:0070034,GO:0072589,GO:0090661,GO:1904874" "cleavage involved in rRNA processing|maturation of LSU-rRNA|chromosome, telomeric region|RNA binding|protein binding|nucleoplasm|telomerase holoenzyme complex|sno(s)RNA-containing ribonucleoprotein complex|telomere maintenance via telomerase|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis|box H/ACA snoRNP complex|box H/ACA snoRNA binding|telomerase RNA binding|box H/ACA scaRNP complex|box H/ACA telomerase RNP complex|positive regulation of telomerase RNA localization to Cajal body" hsa03008 Ribosome biogenesis in eukaryotes NHS 461.8727596 456.7301858 467.0153334 1.022519089 0.032127776 0.944063789 1 2.325502429 2.480299648 4810 NHS actin remodeling regulator "GO:0002088,GO:0005794,GO:0005923,GO:0005925,GO:0016324,GO:0016604,GO:0030027,GO:0030054,GO:0030154" lens development in camera-type eye|Golgi apparatus|bicellular tight junction|focal adhesion|apical plasma membrane|nuclear body|lamellipodium|cell junction|cell differentiation NHSL1 231.5059625 199.9463258 263.0655992 1.315681087 0.395809831 0.443062016 1 0.632950561 0.868633053 57224 NHS like 1 GO:0030154 cell differentiation NHSL2 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.006771993 0 340527 NHS like 2 "GO:0005515,GO:0030154" protein binding|cell differentiation NIBAN1 2125.807947 1892.892881 2358.723013 1.246094291 0.317413241 0.322895573 1 13.30950253 17.29930514 116496 niban apoptosis regulator 1 "GO:0001933,GO:0001934,GO:0003674,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0034976,GO:0045727,GO:0070062" negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|molecular_function|protein binding|cytoplasm|cytosol|plasma membrane|membrane|response to endoplasmic reticulum stress|positive regulation of translation|extracellular exosome NIBAN2 10517.50742 12077.97602 8957.038811 0.741600976 -0.431284952 0.202441161 1 145.6098255 112.6359183 64855 niban apoptosis regulator 2 "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0007411,GO:0008285,GO:0016525,GO:0030154,GO:0030948,GO:0032274,GO:0040019,GO:0043066,GO:0044029,GO:0045296,GO:0045746,GO:0045892,GO:0045893,GO:0048743,GO:0070062,GO:2000279,GO:2000679" "transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|adherens junction|axon guidance|negative regulation of cell population proliferation|negative regulation of angiogenesis|cell differentiation|negative regulation of vascular endothelial growth factor receptor signaling pathway|gonadotropin secretion|positive regulation of embryonic development|negative regulation of apoptotic process|hypomethylation of CpG island|cadherin binding|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of skeletal muscle fiber development|extracellular exosome|negative regulation of DNA biosynthetic process|positive regulation of transcription regulatory region DNA binding" NIBAN3 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.045319761 0.034416793 199786 niban apoptosis regulator 3 GO:0005515 protein binding NICN1 410.5081196 414.1020351 406.914204 0.982642367 -0.025261652 0.959324752 1 6.499165545 6.661453707 84276 nicolin 1 "GO:0005515,GO:0005654,GO:0005874" protein binding|nucleoplasm|microtubule NID1 6443.73694 6574.884763 6312.589117 0.960106427 -0.058733759 0.857286482 1 57.49218205 57.57634589 4811 nidogen 1 "GO:0005201,GO:0005509,GO:0005518,GO:0005576,GO:0005604,GO:0005886,GO:0007160,GO:0010811,GO:0030198,GO:0032836,GO:0043236,GO:0043237,GO:0043394,GO:0062023,GO:0070062,GO:0071711" extracellular matrix structural constituent|calcium ion binding|collagen binding|extracellular region|basement membrane|plasma membrane|cell-matrix adhesion|positive regulation of cell-substrate adhesion|extracellular matrix organization|glomerular basement membrane development|laminin binding|laminin-1 binding|proteoglycan binding|collagen-containing extracellular matrix|extracellular exosome|basement membrane organization NIF3L1 505.8654839 466.8797455 544.8512224 1.167005482 0.222811338 0.586440275 1 12.30271179 14.97578774 60491 NGG1 interacting factor 3 like 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0008134,GO:0030182,GO:0042802,GO:0045893,GO:1903507" "protein binding|nucleus|cytoplasm|mitochondrion|transcription factor binding|neuron differentiation|identical protein binding|positive regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription" NIFK 475.9997495 580.5548139 371.444685 0.639809844 -0.644284905 0.119775145 1 17.43953336 11.63862587 84365 nucleolar protein interacting with the FHA domain of MKI67 "GO:0000463,GO:0000794,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0009303,GO:0016072,GO:0065003" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|condensed nuclear chromosome|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|cytoplasm|rRNA transcription|rRNA metabolic process|protein-containing complex assembly" NIM1K 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.088895701 0 167359 NIM1 serine/threonine protein kinase "GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0035556,GO:0042149,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|intracellular signal transduction|cellular response to glucose starvation|protein serine kinase activity|protein threonine kinase activity NIN 2145.625321 1799.516932 2491.733709 1.38466811 0.46954022 0.143687701 1 7.080971509 10.22714626 51199 ninein "GO:0000242,GO:0000922,GO:0005509,GO:0005515,GO:0005525,GO:0005654,GO:0005730,GO:0005813,GO:0005814,GO:0005881,GO:0005886,GO:0008104,GO:0010457,GO:0019900,GO:0021540,GO:0021957,GO:0030425,GO:0031116,GO:0034454,GO:0044295,GO:0045177,GO:0048668,GO:0050772,GO:0051011,GO:0051642,GO:0072686,GO:0090222,GO:0097431,GO:0097539,GO:0120103" pericentriolar material|spindle pole|calcium ion binding|protein binding|GTP binding|nucleoplasm|nucleolus|centrosome|centriole|cytoplasmic microtubule|plasma membrane|protein localization|centriole-centriole cohesion|kinase binding|corpus callosum morphogenesis|corticospinal tract morphogenesis|dendrite|positive regulation of microtubule polymerization|microtubule anchoring at centrosome|axonal growth cone|apical part of cell|collateral sprouting|positive regulation of axonogenesis|microtubule minus-end binding|centrosome localization|mitotic spindle|centrosome-templated microtubule nucleation|mitotic spindle pole|ciliary transition fiber|centriolar subdistal appendage NINJ1 797.731635 785.5759195 809.8873504 1.030947271 0.043970546 0.908138267 1 30.74702394 33.06400585 4814 ninjurin 1 "GO:0005515,GO:0007155,GO:0007399,GO:0016021,GO:0042246" protein binding|cell adhesion|nervous system development|integral component of membrane|tissue regeneration NINL 715.9682964 618.1081847 813.8284081 1.31664396 0.396865272 0.291280658 1 3.407903223 4.68027675 22981 ninein like "GO:0000086,GO:0005509,GO:0005515,GO:0005813,GO:0005829,GO:0005874,GO:0010389,GO:0015630,GO:0034454,GO:0045171,GO:0097711" G2/M transition of mitotic cell cycle|calcium ion binding|protein binding|centrosome|cytosol|microtubule|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|microtubule anchoring at centrosome|intercellular bridge|ciliary basal body-plasma membrane docking NIP7 665.9019198 765.2768002 566.5270395 0.740290362 -0.433836849 0.256028236 1 18.8606181 14.56377452 51388 nucleolar pre-rRNA processing protein NIP7 "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0030687,GO:0042255,GO:0042273" "RNA binding|protein binding|nucleoplasm|nucleolus|cytosol|preribosome, large subunit precursor|ribosome assembly|ribosomal large subunit biogenesis" NIPA1 962.3435376 992.6269371 932.0601381 0.938983321 -0.090828563 0.800183934 1 7.643766548 7.48654126 123606 NIPA magnesium transporter 1 "GO:0005515,GO:0005769,GO:0005886,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:0055085,GO:1903830" protein binding|early endosome|plasma membrane|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|transmembrane transport|magnesium ion transmembrane transport NIPA2 1273.945906 1481.835714 1066.056099 0.719415849 -0.475102151 0.161264077 1 18.65517059 13.99894013 81614 NIPA magnesium transporter 2 "GO:0005769,GO:0005886,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:1903830" early endosome|plasma membrane|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|magnesium ion transmembrane transport NIPAL1 219.7839883 240.5445645 199.0234121 0.827386861 -0.273366047 0.604880188 1 2.297761902 1.983031322 152519 NIPA like domain containing 1 "GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:1903830" magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|magnesium ion transmembrane transport NIPAL2 329.2698264 215.1706653 443.3689874 2.060545692 1.043026455 0.024061205 0.685137768 2.265149682 4.868498996 79815 NIPA like domain containing 2 "GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:1903830" magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|magnesium ion transmembrane transport NIPAL3 371.4607686 169.4976467 573.4238904 3.383078771 1.758336769 0.000112775 0.018079825 1.134909817 4.004878937 57185 NIPA like domain containing 3 "GO:0005515,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:1903830" protein binding|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|magnesium ion transmembrane transport NIPAL4 15.15011065 25.37389921 4.926322083 0.194149194 -2.364762376 0.064048195 1 0.367066119 0.074335424 348938 NIPA like domain containing 4 "GO:0005515,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:1903830" protein binding|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|magnesium ion transmembrane transport NIPBL 2387.59112 2243.05269 2532.129551 1.128876536 0.174887709 0.584436434 1 9.559298699 11.25611206 25836 NIPBL cohesin loading factor "GO:0000122,GO:0001656,GO:0003007,GO:0003151,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006974,GO:0007064,GO:0007420,GO:0007605,GO:0008022,GO:0019827,GO:0031065,GO:0032039,GO:0032116,GO:0034087,GO:0034088,GO:0034613,GO:0035115,GO:0035136,GO:0035261,GO:0036033,GO:0040018,GO:0042471,GO:0042634,GO:0042826,GO:0043231,GO:0045444,GO:0045778,GO:0045892,GO:0045995,GO:0047485,GO:0048557,GO:0048565,GO:0048589,GO:0048592,GO:0048638,GO:0048703,GO:0050890,GO:0060325,GO:0061010,GO:0061038,GO:0070062,GO:0070087,GO:0071169,GO:0071481,GO:0071733,GO:0071921,GO:0090694,GO:1905406,GO:1990414,GO:1990841,GO:2001224" "negative regulation of transcription by RNA polymerase II|metanephros development|heart morphogenesis|outflow tract morphogenesis|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|cellular response to DNA damage stimulus|mitotic sister chromatid cohesion|brain development|sensory perception of sound|protein C-terminus binding|stem cell population maintenance|positive regulation of histone deacetylation|integrator complex|SMC loading complex|establishment of mitotic sister chromatid cohesion|maintenance of mitotic sister chromatid cohesion|cellular protein localization|embryonic forelimb morphogenesis|forelimb morphogenesis|external genitalia morphogenesis|mediator complex binding|positive regulation of multicellular organism growth|ear morphogenesis|regulation of hair cycle|histone deacetylase binding|intracellular membrane-bounded organelle|fat cell differentiation|positive regulation of ossification|negative regulation of transcription, DNA-templated|regulation of embryonic development|protein N-terminus binding|embryonic digestive tract morphogenesis|digestive tract development|developmental growth|eye morphogenesis|regulation of developmental growth|embryonic viscerocranium morphogenesis|cognition|face morphogenesis|gall bladder development|uterus morphogenesis|extracellular exosome|chromo shadow domain binding|establishment of protein localization to chromatin|cellular response to X-ray|transcriptional activation by promoter-enhancer looping|cohesin loading|Scc2-Scc4 cohesin loading complex|positive regulation of mitotic cohesin loading|replication-born double-strand break repair via sister chromatid exchange|promoter-specific chromatin binding|positive regulation of neuron migration" other NIPSNAP1 2420.575705 2511.001066 2330.150345 0.927976645 -0.107839598 0.736321493 1 63.17602866 61.15124425 8508 nipsnap homolog 1 "GO:0005515,GO:0005739,GO:0019233,GO:0042165,GO:0097060" protein binding|mitochondrion|sensory perception of pain|neurotransmitter binding|synaptic membrane NIPSNAP2 1248.568048 1296.098772 1201.037324 0.926655707 -0.10989468 0.748067532 1 32.93669364 31.83569496 2631 nipsnap homolog 2 "GO:0005515,GO:0005739,GO:0005741,GO:0006119,GO:0007005,GO:1901843" protein binding|mitochondrion|mitochondrial outer membrane|oxidative phosphorylation|mitochondrion organization|positive regulation of high voltage-gated calcium channel activity NIPSNAP3A 271.7330568 255.768904 287.6972096 1.124832632 0.169710354 0.733101488 1 7.917966192 9.290037777 25934 nipsnap homolog 3A "GO:0005515,GO:0005634,GO:0005739,GO:0005829" protein binding|nucleus|mitochondrion|cytosol NIPSNAP3B 101.7737072 87.28621328 116.2612012 1.331953773 0.413544013 0.544681328 1 0.744859103 1.034854308 55335 nipsnap homolog 3B GO:0005739 mitochondrion NISCH 2430.894258 2105.018678 2756.769837 1.309617756 0.389145787 0.223116703 1 14.94208409 20.41134675 11188 nischarin "GO:0005178,GO:0005515,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0006006,GO:0006915,GO:0008217,GO:0015630,GO:0016020,GO:0016601,GO:0019901,GO:0030036,GO:0030336,GO:0032228,GO:0035091,GO:0042802,GO:0043231,GO:0045171,GO:0048243,GO:0055037" "integrin binding|protein binding|nucleoplasm|cytoplasm|early endosome|cytosol|plasma membrane|glucose metabolic process|apoptotic process|regulation of blood pressure|microtubule cytoskeleton|membrane|Rac protein signal transduction|protein kinase binding|actin cytoskeleton organization|negative regulation of cell migration|regulation of synaptic transmission, GABAergic|phosphatidylinositol binding|identical protein binding|intracellular membrane-bounded organelle|intercellular bridge|norepinephrine secretion|recycling endosome" NIT1 750.3580331 679.0055428 821.7105234 1.210167622 0.275206892 0.460399182 1 10.82443669 13.6636511 4817 nitrilase 1 "GO:0005634,GO:0005737,GO:0005739,GO:0043605,GO:0110050" nucleus|cytoplasm|mitochondrion|cellular amide catabolic process|deaminated glutathione amidase activity NIT2 668.4420314 736.858033 600.0260297 0.814303438 -0.296361601 0.437961611 1 5.159582455 4.382447836 56954 nitrilase family member 2 "GO:0005576,GO:0005813,GO:0005829,GO:0006107,GO:0006528,GO:0006541,GO:0035580,GO:0043312,GO:0050152,GO:0070062,GO:1904724" extracellular region|centrosome|cytosol|oxaloacetate metabolic process|asparagine metabolic process|glutamine metabolic process|specific granule lumen|neutrophil degranulation|omega-amidase activity|extracellular exosome|tertiary granule lumen hsa00250 "Alanine, aspartate and glutamate metabolism" NKAP 484.1302836 462.8199216 505.4406457 1.092089217 0.12709072 0.761309308 1 3.885974187 4.426637514 79576 NFKB activating protein "GO:0000122,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007219,GO:0010468,GO:0045892,GO:0046638" "negative regulation of transcription by RNA polymerase II|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|Notch signaling pathway|regulation of gene expression|negative regulation of transcription, DNA-templated|positive regulation of alpha-beta T cell differentiation" NKAPD1 562.2576449 550.1061349 574.4091548 1.044178784 0.062368751 0.879358195 1 8.906948553 9.701072232 55216 NKAP domain containing 1 "GO:0005515,GO:0042802" protein binding|identical protein binding NKD1 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.005903071 0.011954447 85407 NKD inhibitor of WNT signaling pathway 1 "GO:0000159,GO:0001754,GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0007525,GO:0016055,GO:0030165,GO:0030178,GO:0045732,GO:0090090,GO:0090249,GO:1901231,GO:1901233,GO:2000096" "protein phosphatase type 2A complex|eye photoreceptor cell differentiation|calcium ion binding|protein binding|cytoplasm|plasma membrane|somatic muscle development|Wnt signaling pathway|PDZ domain binding|negative regulation of Wnt signaling pathway|positive regulation of protein catabolic process|negative regulation of canonical Wnt signaling pathway|regulation of cell migration involved in somitogenic axis elongation|positive regulation of non-canonical Wnt signaling pathway via JNK cascade|negative regulation of convergent extension involved in axis elongation|positive regulation of Wnt signaling pathway, planar cell polarity pathway" "hsa04310,hsa04390" Wnt signaling pathway|Hippo signaling pathway NKIRAS1 405.7181311 389.7430919 421.6931703 1.08197728 0.113670204 0.796915056 1 3.37190172 3.805475925 28512 NFKB inhibitor interacting Ras like 1 "GO:0003924,GO:0005525,GO:0005575,GO:0005783,GO:0005829,GO:0007249" GTPase activity|GTP binding|cellular_component|endoplasmic reticulum|cytosol|I-kappaB kinase/NF-kappaB signaling NKIRAS2 1191.507827 1167.199364 1215.81629 1.041652633 0.058874252 0.865677682 1 22.84178135 24.81811631 28511 NFKB inhibitor interacting Ras like 2 "GO:0003924,GO:0005525,GO:0005575,GO:0005737,GO:0007249" GTPase activity|GTP binding|cellular_component|cytoplasm|I-kappaB kinase/NF-kappaB signaling NKRF 761.9624788 798.7703471 725.1546106 0.907838671 -0.139492151 0.709072709 1 10.65724452 10.09182099 55922 NFKB repressing factor "GO:0000978,GO:0001228,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0045892,GO:0045944" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II" NKTR 2853.358916 2898.714246 2808.003587 0.968706588 -0.045868341 0.886409377 1 12.9759281 13.11132593 4820 natural killer cell triggering receptor "GO:0000413,GO:0003755,GO:0005634,GO:0005737,GO:0005886,GO:0006457,GO:0016018,GO:0043231" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|nucleus|cytoplasm|plasma membrane|protein folding|cyclosporin A binding|intracellular membrane-bounded organelle NKX2-5 304.9324099 268.9633316 340.9014881 1.26746455 0.341945397 0.469049422 1 5.245299923 6.934610567 1482 NK2 homeobox 5 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001216,GO:0001228,GO:0001570,GO:0001947,GO:0003007,GO:0003148,GO:0003161,GO:0003180,GO:0003221,GO:0003228,GO:0003285,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007512,GO:0008134,GO:0008284,GO:0010667,GO:0010735,GO:0010765,GO:0010832,GO:0030097,GO:0030154,GO:0030878,GO:0032991,GO:0032993,GO:0035050,GO:0043066,GO:0043565,GO:0045666,GO:0045823,GO:0045892,GO:0045893,GO:0045944,GO:0048536,GO:0051891,GO:0055007,GO:0055008,GO:0055013,GO:0055014,GO:0055015,GO:0055117,GO:0060037,GO:0060048,GO:0060261,GO:0060412,GO:0060413,GO:0090090,GO:0090575,GO:1903779,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|vasculogenesis|heart looping|heart morphogenesis|outflow tract septum morphogenesis|cardiac conduction system development|aortic valve morphogenesis|right ventricular cardiac muscle tissue morphogenesis|atrial cardiac muscle tissue development|septum secundum development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|adult heart development|transcription factor binding|positive regulation of cell population proliferation|negative regulation of cardiac muscle cell apoptotic process|positive regulation of transcription via serum response element binding|positive regulation of sodium ion transport|negative regulation of myotube differentiation|hemopoiesis|cell differentiation|thyroid gland development|protein-containing complex|protein-DNA complex|embryonic heart tube development|negative regulation of apoptotic process|sequence-specific DNA binding|positive regulation of neuron differentiation|positive regulation of heart contraction|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|spleen development|positive regulation of cardioblast differentiation|cardiac muscle cell differentiation|cardiac muscle tissue morphogenesis|cardiac muscle cell development|atrial cardiac muscle cell development|ventricular cardiac muscle cell development|regulation of cardiac muscle contraction|pharyngeal system development|cardiac muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|ventricular septum morphogenesis|atrial septum morphogenesis|negative regulation of canonical Wnt signaling pathway|RNA polymerase II transcription regulator complex|regulation of cardiac conduction|sequence-specific double-stranded DNA binding" Homeobox NKX2-8 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.111565793 0.028241814 26257 NK2 homeobox 8 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001889,GO:0003690,GO:0003700,GO:0005575,GO:0005634,GO:0006351,GO:0006357,GO:0006366,GO:0007409,GO:0030154,GO:0030324,GO:0043565,GO:0045944,GO:0050680,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|double-stranded DNA binding|DNA-binding transcription factor activity|cellular_component|nucleus|transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|axonogenesis|cell differentiation|lung development|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|negative regulation of epithelial cell proliferation|sequence-specific double-stranded DNA binding" NKX3-1 398.675544 346.0999852 451.2511028 1.303817169 0.382741578 0.378708136 1 5.34087242 7.263481407 4824 NK3 homeobox 1 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001656,GO:0001756,GO:0001934,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0006919,GO:0007275,GO:0007431,GO:0007507,GO:0008134,GO:0008284,GO:0008285,GO:0008584,GO:0008656,GO:0010628,GO:0010629,GO:0010942,GO:0014068,GO:0030154,GO:0030284,GO:0030331,GO:0030521,GO:0032880,GO:0033574,GO:0035690,GO:0035907,GO:0042826,GO:0043280,GO:0043491,GO:0043565,GO:0043569,GO:0043621,GO:0045892,GO:0045893,GO:0045930,GO:0045931,GO:0045944,GO:0048754,GO:0050680,GO:0051091,GO:0051781,GO:0060037,GO:0060442,GO:0060664,GO:0060770,GO:0071347,GO:0071356,GO:0071383,GO:0071456,GO:0071850,GO:0071899,GO:0090734,GO:0097162,GO:1990837,GO:2000836,GO:2001022,GO:2001235,GO:2001244" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|metanephros development|somitogenesis|positive regulation of protein phosphorylation|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|activation of cysteine-type endopeptidase activity involved in apoptotic process|multicellular organism development|salivary gland development|heart development|transcription factor binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|male gonad development|cysteine-type endopeptidase activator activity involved in apoptotic process|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell death|positive regulation of phosphatidylinositol 3-kinase signaling|cell differentiation|estrogen receptor activity|estrogen receptor binding|androgen receptor signaling pathway|regulation of protein localization|response to testosterone|cellular response to drug|dorsal aorta development|histone deacetylase binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein kinase B signaling|sequence-specific DNA binding|negative regulation of insulin-like growth factor receptor signaling pathway|protein self-association|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|branching morphogenesis of an epithelial tube|negative regulation of epithelial cell proliferation|positive regulation of DNA-binding transcription factor activity|positive regulation of cell division|pharyngeal system development|branching involved in prostate gland morphogenesis|epithelial cell proliferation involved in salivary gland morphogenesis|negative regulation of epithelial cell proliferation involved in prostate gland development|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to steroid hormone stimulus|cellular response to hypoxia|mitotic cell cycle arrest|negative regulation of estrogen receptor binding|site of DNA damage|MADS box domain binding|sequence-specific double-stranded DNA binding|positive regulation of androgen secretion|positive regulation of response to DNA damage stimulus|positive regulation of apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway" "hsa05200,hsa05215" Pathways in cancer|Prostate cancer Homeobox NKX3-2 7.015617123 8.119647747 5.911586499 0.728059478 -0.457871781 0.855058357 1 0.182041396 0.138246119 579 NK3 homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001501,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0007368,GO:0030154,GO:0031016,GO:0032331,GO:0042474,GO:0043066,GO:0048536,GO:0048645,GO:0048705,GO:0048706,GO:0060576,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|determination of left/right symmetry|cell differentiation|pancreas development|negative regulation of chondrocyte differentiation|middle ear morphogenesis|negative regulation of apoptotic process|spleen development|animal organ formation|skeletal system morphogenesis|embryonic skeletal system development|intestinal epithelial cell development|sequence-specific double-stranded DNA binding" NLE1 810.1525984 961.163302 659.1418947 0.685775137 -0.544192496 0.137779234 1 9.095577442 6.506207963 54475 notchless homolog 1 "GO:0000027,GO:0001756,GO:0001822,GO:0001826,GO:0005654,GO:0005730,GO:0007219,GO:0045930,GO:0048705,GO:0061484,GO:0090263,GO:2001268" ribosomal large subunit assembly|somitogenesis|kidney development|inner cell mass cell differentiation|nucleoplasm|nucleolus|Notch signaling pathway|negative regulation of mitotic cell cycle|skeletal system morphogenesis|hematopoietic stem cell homeostasis|positive regulation of canonical Wnt signaling pathway|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway NLGN2 3106.138622 2902.77407 3309.503175 1.140117383 0.189182367 0.552251164 1 28.83217616 34.28806048 57555 neuroligin 2 "GO:0002087,GO:0005886,GO:0005887,GO:0007158,GO:0007268,GO:0007416,GO:0009986,GO:0016020,GO:0019233,GO:0032024,GO:0032230,GO:0035418,GO:0035641,GO:0038023,GO:0042043,GO:0042734,GO:0042802,GO:0042995,GO:0045202,GO:0045211,GO:0045217,GO:0048488,GO:0050804,GO:0050808,GO:0050839,GO:0050885,GO:0051965,GO:0051968,GO:0060077,GO:0072553,GO:0089717,GO:0097104,GO:0097105,GO:0097116,GO:0097119,GO:0097151,GO:0098609,GO:0098690,GO:0098691,GO:0098983,GO:0099054,GO:0099055,GO:0099060,GO:1902474,GO:1904862,GO:2000311,GO:2000463,GO:2000809" "regulation of respiratory gaseous exchange by nervous system process|plasma membrane|integral component of plasma membrane|neuron cell-cell adhesion|chemical synaptic transmission|synapse assembly|cell surface|membrane|sensory perception of pain|positive regulation of insulin secretion|positive regulation of synaptic transmission, GABAergic|protein localization to synapse|locomotory exploration behavior|signaling receptor activity|neurexin family protein binding|presynaptic membrane|identical protein binding|cell projection|synapse|postsynaptic membrane|cell-cell junction maintenance|synaptic vesicle endocytosis|modulation of chemical synaptic transmission|synapse organization|cell adhesion molecule binding|neuromuscular process controlling balance|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|inhibitory synapse|terminal button organization|spanning component of membrane|postsynaptic membrane assembly|presynaptic membrane assembly|gephyrin clustering involved in postsynaptic density assembly|postsynaptic density protein 95 clustering|positive regulation of inhibitory postsynaptic potential|cell-cell adhesion|glycinergic synapse|dopaminergic synapse|symmetric, GABA-ergic, inhibitory synapse|presynapse assembly|integral component of postsynaptic membrane|integral component of postsynaptic specialization membrane|positive regulation of protein localization to synapse|inhibitory synapse assembly|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of synaptic vesicle clustering" hsa04514 Cell adhesion molecules NLGN3 7.523095107 9.134603715 5.911586499 0.64716398 -0.627796782 0.748279434 1 0.062772789 0.042374217 54413 neuroligin 3 "GO:0002087,GO:0005515,GO:0005886,GO:0005887,GO:0006898,GO:0007158,GO:0007268,GO:0007416,GO:0007612,GO:0009986,GO:0030139,GO:0030534,GO:0035176,GO:0038023,GO:0042043,GO:0045202,GO:0048488,GO:0048675,GO:0050804,GO:0050808,GO:0050839,GO:0051965,GO:0051968,GO:0060024,GO:0060076,GO:0060080,GO:0071625,GO:0089717,GO:0097104,GO:0097105,GO:0097110,GO:0098793,GO:0098983,GO:0098985,GO:0099054,GO:0099055,GO:2000463,GO:2000969" "regulation of respiratory gaseous exchange by nervous system process|protein binding|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|neuron cell-cell adhesion|chemical synaptic transmission|synapse assembly|learning|cell surface|endocytic vesicle|adult behavior|social behavior|signaling receptor activity|neurexin family protein binding|synapse|synaptic vesicle endocytosis|axon extension|modulation of chemical synaptic transmission|synapse organization|cell adhesion molecule binding|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|rhythmic synaptic transmission|excitatory synapse|inhibitory postsynaptic potential|vocalization behavior|spanning component of membrane|postsynaptic membrane assembly|presynaptic membrane assembly|scaffold protein binding|presynapse|symmetric, GABA-ergic, inhibitory synapse|asymmetric, glutamatergic, excitatory synapse|presynapse assembly|integral component of postsynaptic membrane|positive regulation of excitatory postsynaptic potential|positive regulation of AMPA receptor activity" hsa04514 Cell adhesion molecules NLK 683.1131178 594.7641975 771.4620382 1.297088899 0.375277362 0.323293163 1 8.470952868 11.46087927 51701 nemo like kinase "GO:0000165,GO:0000287,GO:0004672,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006468,GO:0007179,GO:0007223,GO:0008134,GO:0010468,GO:0018107,GO:0030178,GO:0031625,GO:0035556,GO:0042169,GO:0042501,GO:0046777,GO:0050821" "MAPK cascade|magnesium ion binding|protein kinase activity|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|protein phosphorylation|transforming growth factor beta receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|transcription factor binding|regulation of gene expression|peptidyl-threonine phosphorylation|negative regulation of Wnt signaling pathway|ubiquitin protein ligase binding|intracellular signal transduction|SH2 domain binding|serine phosphorylation of STAT protein|protein autophosphorylation|protein stabilization" "hsa04010,hsa04068,hsa04310,hsa04520" MAPK signaling pathway|FoxO signaling pathway|Wnt signaling pathway|Adherens junction NLN 871.0432755 981.4624214 760.6241296 0.774990578 -0.367749323 0.308961575 1 11.94320261 9.654574815 57486 neurolysin "GO:0004222,GO:0005576,GO:0005758,GO:0005886,GO:0006111,GO:0006508,GO:0006518,GO:0042277,GO:0046872,GO:1902809" metalloendopeptidase activity|extracellular region|mitochondrial intermembrane space|plasma membrane|regulation of gluconeogenesis|proteolysis|peptide metabolic process|peptide binding|metal ion binding|regulation of skeletal muscle fiber differentiation hsa04614 Renin-angiotensin system NLRC5 243.9647823 277.0829794 210.8465851 0.760951054 -0.394124436 0.436994002 1 1.751313542 1.390069641 84166 NLR family CARD domain containing 5 "GO:0000978,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0009617,GO:0032088,GO:0032480,GO:0035556,GO:0043549,GO:0045087,GO:0045345,GO:0045944,GO:0051607,GO:0060335,GO:0060339,GO:0060340" RNA polymerase II cis-regulatory region sequence-specific DNA binding|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|response to bacterium|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|intracellular signal transduction|regulation of kinase activity|innate immune response|positive regulation of MHC class I biosynthetic process|positive regulation of transcription by RNA polymerase II|defense response to virus|positive regulation of interferon-gamma-mediated signaling pathway|negative regulation of type I interferon-mediated signaling pathway|positive regulation of type I interferon-mediated signaling pathway NLRP1 1639.53715 1317.412847 1961.661453 1.489025599 0.574368556 0.080480226 1 10.93987754 16.99145441 22861 NLR family pyrin domain containing 1 "GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006915,GO:0006919,GO:0006954,GO:0008656,GO:0016032,GO:0019899,GO:0019904,GO:0032495,GO:0032731,GO:0042742,GO:0042981,GO:0050727,GO:0051402,GO:0051607,GO:0061702,GO:0070269,GO:0072558,GO:0097264,GO:0140374,GO:1904784" protein binding|ATP binding|nucleus|nucleoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|cysteine-type endopeptidase activator activity involved in apoptotic process|viral process|enzyme binding|protein domain specific binding|response to muramyl dipeptide|positive regulation of interleukin-1 beta production|defense response to bacterium|regulation of apoptotic process|regulation of inflammatory response|neuron apoptotic process|defense response to virus|inflammasome complex|pyroptosis|NLRP1 inflammasome complex|self proteolysis|antiviral innate immune response|NLRP1 inflammasome complex assembly hsa04621 NOD-like receptor signaling pathway NLRP14 5.941278051 2.029911937 9.852644165 4.853729853 2.279093814 0.221443742 1 0.025428612 0.128740202 338323 NLR family pyrin domain containing 14 "GO:0005524,GO:0005737,GO:0007275,GO:0007283,GO:0030154" ATP binding|cytoplasm|multicellular organism development|spermatogenesis|cell differentiation NLRP3 128.7915282 115.7049804 141.878076 1.226205436 0.294200706 0.64329504 1 1.396247099 1.785835495 114548 NLR family pyrin domain containing 3 "GO:0000139,GO:0002523,GO:0002674,GO:0002830,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0006915,GO:0006952,GO:0006954,GO:0007165,GO:0008134,GO:0009595,GO:0014070,GO:0016579,GO:0032088,GO:0032691,GO:0032731,GO:0032753,GO:0042802,GO:0042834,GO:0043280,GO:0043565,GO:0045087,GO:0045471,GO:0045630,GO:0045944,GO:0050728,GO:0051092,GO:0071222,GO:0072559,GO:1901223,GO:2000553" Golgi membrane|leukocyte migration involved in inflammatory response|negative regulation of acute inflammatory response|positive regulation of type 2 immune response|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|endoplasmic reticulum|cytosol|apoptotic process|defense response|inflammatory response|signal transduction|transcription factor binding|detection of biotic stimulus|response to organic cyclic compound|protein deubiquitination|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-1 beta production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-4 production|identical protein binding|peptidoglycan binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|sequence-specific DNA binding|innate immune response|response to ethanol|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|cellular response to lipopolysaccharide|NLRP3 inflammasome complex|negative regulation of NIK/NF-kappaB signaling|positive regulation of T-helper 2 cell cytokine production "hsa04217,hsa04621,hsa04625,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05164,hsa05171" Necroptosis|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Influenza A|Coronavirus disease - COVID-19 NLRX1 601.6721809 685.0952787 518.2490831 0.756462786 -0.402658984 0.302980683 1 7.848373443 6.192744427 79671 NLR family member X1 "GO:0005515,GO:0005524,GO:0005739,GO:0005741,GO:0005886,GO:0016032,GO:0030054,GO:0032480,GO:0032688,GO:0032715,GO:0035556,GO:0039536,GO:0043124,GO:0045087,GO:0045824,GO:0050728" protein binding|ATP binding|mitochondrion|mitochondrial outer membrane|plasma membrane|viral process|cell junction|negative regulation of type I interferon production|negative regulation of interferon-beta production|negative regulation of interleukin-6 production|intracellular signal transduction|negative regulation of RIG-I signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of innate immune response|negative regulation of inflammatory response "hsa04621,hsa04622,hsa05164" NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Influenza A NMB 172.4022217 234.4548287 110.3496147 0.470664713 -1.087228401 0.055970607 1 8.524271333 4.184897584 4828 neuromedin B "GO:0005179,GO:0005184,GO:0005515,GO:0005576,GO:0007165,GO:0007186,GO:0007204,GO:0007218,GO:0007267,GO:0008284,GO:0031710,GO:0042593,GO:0043005,GO:0046887,GO:0046888,GO:0050482" hormone activity|neuropeptide hormone activity|protein binding|extracellular region|signal transduction|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|cell-cell signaling|positive regulation of cell population proliferation|neuromedin B receptor binding|glucose homeostasis|neuron projection|positive regulation of hormone secretion|negative regulation of hormone secretion|arachidonic acid secretion hsa04080 Neuroactive ligand-receptor interaction NMD3 863.8616332 995.671805 732.0514615 0.735233696 -0.443725207 0.220283777 1 12.26045816 9.40260154 51068 NMD3 ribosome export adaptor "GO:0000055,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0016020,GO:0030674,GO:0032092,GO:0043023,GO:1902680,GO:1904751" ribosomal large subunit export from nucleus|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|membrane|protein-macromolecule adaptor activity|positive regulation of protein binding|ribosomal large subunit binding|positive regulation of RNA biosynthetic process|positive regulation of protein localization to nucleolus "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport NME1 595.0398323 736.858033 453.2216316 0.615073204 -0.701169968 0.073939502 1 36.1971483 23.22293434 4830 NME/NM23 nucleoside diphosphate kinase 1 "GO:0000287,GO:0000977,GO:0002762,GO:0003697,GO:0003723,GO:0004536,GO:0004550,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005741,GO:0005813,GO:0005829,GO:0005882,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0006259,GO:0006897,GO:0007595,GO:0008285,GO:0010629,GO:0010976,GO:0014075,GO:0015949,GO:0016020,GO:0019215,GO:0019899,GO:0021766,GO:0030154,GO:0032587,GO:0033574,GO:0035690,GO:0042802,GO:0042981,GO:0043015,GO:0043024,GO:0043388,GO:0048471,GO:0050679,GO:0051591,GO:0070062,GO:0071333,GO:0071398" magnesium ion binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|negative regulation of myeloid leukocyte differentiation|single-stranded DNA binding|RNA binding|deoxyribonuclease activity|nucleoside diphosphate kinase activity|protein binding|ATP binding|GTP binding|nucleus|cytoplasm|mitochondrial outer membrane|centrosome|cytosol|intermediate filament|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|DNA metabolic process|endocytosis|lactation|negative regulation of cell population proliferation|negative regulation of gene expression|positive regulation of neuron projection development|response to amine|nucleobase-containing small molecule interconversion|membrane|intermediate filament binding|enzyme binding|hippocampus development|cell differentiation|ruffle membrane|response to testosterone|cellular response to drug|identical protein binding|regulation of apoptotic process|gamma-tubulin binding|ribosomal small subunit binding|positive regulation of DNA binding|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|response to cAMP|extracellular exosome|cellular response to glucose stimulus|cellular response to fatty acid "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME2 18.56884455 23.34398727 13.79370183 0.590888852 -0.759041315 0.520965803 1 1.177580282 0.725792123 4831 NME/NM23 nucleoside diphosphate kinase 2 "GO:0001726,GO:0002762,GO:0003677,GO:0003713,GO:0004550,GO:0004673,GO:0004674,GO:0005504,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005882,GO:0005925,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0007155,GO:0007189,GO:0007229,GO:0008144,GO:0009142,GO:0010976,GO:0015949,GO:0018106,GO:0019003,GO:0019215,GO:0019899,GO:0030027,GO:0031966,GO:0034599,GO:0034774,GO:0042802,GO:0042981,GO:0043066,GO:0043312,GO:0045618,GO:0045682,GO:0045893,GO:0045944,GO:0046777,GO:0046872,GO:0048471,GO:0050679,GO:0051880,GO:0060416,GO:0070062,GO:0071333,GO:0071398,GO:0071944,GO:1904813" "ruffle|negative regulation of myeloid leukocyte differentiation|DNA binding|transcription coactivator activity|nucleoside diphosphate kinase activity|protein histidine kinase activity|protein serine/threonine kinase activity|fatty acid binding|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|cytosol|intermediate filament|focal adhesion|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|cell adhesion|adenylate cyclase-activating G protein-coupled receptor signaling pathway|integrin-mediated signaling pathway|drug binding|nucleoside triphosphate biosynthetic process|positive regulation of neuron projection development|nucleobase-containing small molecule interconversion|peptidyl-histidine phosphorylation|GDP binding|intermediate filament binding|enzyme binding|lamellipodium|mitochondrial membrane|cellular response to oxidative stress|secretory granule lumen|identical protein binding|regulation of apoptotic process|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of keratinocyte differentiation|regulation of epidermis development|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|metal ion binding|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|G-quadruplex DNA binding|response to growth hormone|extracellular exosome|cellular response to glucose stimulus|cellular response to fatty acid|cell periphery|ficolin-1-rich granule lumen" "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME3 377.7959555 467.8947014 287.6972096 0.614875973 -0.701632663 0.111909738 1 27.5869802 17.69325006 4832 NME/NM23 nucleoside diphosphate kinase 3 "GO:0004550,GO:0005515,GO:0005524,GO:0005829,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0006915,GO:0015949,GO:0046872" nucleoside diphosphate kinase activity|protein binding|ATP binding|cytosol|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|apoptotic process|nucleobase-containing small molecule interconversion|metal ion binding "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME4 2272.904809 2519.120714 2026.688905 0.804522345 -0.313795603 0.326848883 1 61.42733616 51.54846329 4833 NME/NM23 nucleoside diphosphate kinase 4 "GO:0004550,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0006869,GO:0009116,GO:0015949,GO:0046872,GO:1901612" nucleoside diphosphate kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|lipid transport|nucleoside metabolic process|nucleobase-containing small molecule interconversion|metal ion binding|cardiolipin binding "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME6 847.4968906 853.5779694 841.4158117 0.985751556 -0.020704012 0.958037739 1 6.671406313 6.859631606 10201 NME/NM23 nucleoside diphosphate kinase 6 "GO:0004550,GO:0005515,GO:0005524,GO:0005739,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0006915,GO:0030308,GO:0045839,GO:0046872" nucleoside diphosphate kinase activity|protein binding|ATP binding|mitochondrion|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|apoptotic process|negative regulation of cell growth|negative regulation of mitotic nuclear division|metal ion binding "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME7 337.4082793 367.4140606 307.402498 0.836665035 -0.257277949 0.575137357 1 12.64145789 11.03226568 29922 NME/NM23 family member 7 "GO:0004550,GO:0005515,GO:0005524,GO:0005813,GO:0005829,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0046872" nucleoside diphosphate kinase activity|protein binding|ATP binding|centrosome|cytosol|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|metal ion binding "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME9 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.014889622 0.005025554 347736 NME/NM23 family member 9 "GO:0004550,GO:0005737,GO:0005856,GO:0006165,GO:0006183,GO:0006228,GO:0006241" nucleoside diphosphate kinase activity|cytoplasm|cytoskeleton|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process NMI 166.0776751 172.5425146 159.6128355 0.925063807 -0.112375215 0.853846218 1 5.357860007 5.169862367 9111 N-myc and STAT interactor "GO:0002281,GO:0003712,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006366,GO:0007259,GO:0008285,GO:0009615,GO:0016020,GO:0032687,GO:0032688,GO:0034142,GO:0042802,GO:0045089,GO:0045824,GO:0050729,GO:0060333,GO:1901223,GO:1901224,GO:1902524" "macrophage activation involved in immune response|transcription coregulator activity|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription by RNA polymerase II|receptor signaling pathway via JAK-STAT|negative regulation of cell population proliferation|response to virus|membrane|negative regulation of interferon-alpha production|negative regulation of interferon-beta production|toll-like receptor 4 signaling pathway|identical protein binding|positive regulation of innate immune response|negative regulation of innate immune response|positive regulation of inflammatory response|interferon-gamma-mediated signaling pathway|negative regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling|positive regulation of protein K48-linked ubiquitination" NMNAT1 187.988303 222.2753571 153.701249 0.69149028 -0.532219122 0.334150022 1 4.123612709 2.974266498 64802 nicotinamide nucleotide adenylyltransferase 1 "GO:0000309,GO:0004515,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0009165,GO:0009435,GO:0009611,GO:0016604,GO:0019674,GO:0042802,GO:0043410,GO:0043524,GO:1902511,GO:1990966" nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|nucleotide biosynthetic process|NAD biosynthetic process|response to wounding|nuclear body|NAD metabolic process|identical protein binding|positive regulation of MAPK cascade|negative regulation of neuron apoptotic process|negative regulation of apoptotic DNA fragmentation|ATP generation from poly-ADP-D-ribose hsa00760 Nicotinate and nicotinamide metabolism NMNAT2 626.0974343 468.9096574 783.2852112 1.670439495 0.740227728 0.056464964 1 4.033393331 7.027765395 23057 nicotinamide nucleotide adenylyltransferase 2 "GO:0000139,GO:0000309,GO:0004515,GO:0005524,GO:0005770,GO:0005794,GO:0005802,GO:0005829,GO:0009165,GO:0009435,GO:0019674,GO:0030424,GO:0030659,GO:0045202" Golgi membrane|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|ATP binding|late endosome|Golgi apparatus|trans-Golgi network|cytosol|nucleotide biosynthetic process|NAD biosynthetic process|NAD metabolic process|axon|cytoplasmic vesicle membrane|synapse hsa00760 Nicotinate and nicotinamide metabolism NMRAL1 537.9377957 571.4202102 504.4553813 0.882809835 -0.179825393 0.656461792 1 12.07863848 11.1224657 57407 NmrA like redox sensor 1 "GO:0000050,GO:0005515,GO:0005654,GO:0005829,GO:0042802,GO:0048471" urea cycle|protein binding|nucleoplasm|cytosol|identical protein binding|perinuclear region of cytoplasm NMRK1 147.4049101 142.0938356 152.7159846 1.074754467 0.104007107 0.871989448 1 2.041574892 2.288708617 54981 nicotinamide riboside kinase 1 "GO:0005515,GO:0005524,GO:0005829,GO:0009435,GO:0016301,GO:0016310,GO:0019674,GO:0046872,GO:0050262,GO:0061769" protein binding|ATP binding|cytosol|NAD biosynthetic process|kinase activity|phosphorylation|NAD metabolic process|metal ion binding|ribosylnicotinamide kinase activity|ribosylnicotinate kinase activity hsa00760 Nicotinate and nicotinamide metabolism NMT1 3844.503252 3839.578428 3849.428075 1.002565294 0.003696198 0.991665277 1 39.84042249 41.66319117 4836 N-myristoyltransferase 1 "GO:0001701,GO:0004379,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006499,GO:0018008,GO:0019107,GO:0019898,GO:0022400,GO:0042180,GO:1900740" in utero embryonic development|glycylpeptide N-tetradecanoyltransferase activity|protein binding|cytoplasm|mitochondrion|cytosol|plasma membrane|N-terminal protein myristoylation|N-terminal peptidyl-glycine N-myristoylation|myristoyltransferase activity|extrinsic component of membrane|regulation of rhodopsin mediated signaling pathway|cellular ketone metabolic process|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway NMT2 1433.176957 1219.977074 1646.37684 1.349514573 0.432440556 0.194897237 1 10.96885052 15.44026062 9397 N-myristoyltransferase 2 "GO:0004379,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0018008,GO:0019898,GO:0022400,GO:0043657,GO:0075733" glycylpeptide N-tetradecanoyltransferase activity|protein binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|N-terminal peptidyl-glycine N-myristoylation|extrinsic component of membrane|regulation of rhodopsin mediated signaling pathway|host cell|intracellular transport of virus NMU 175.0665426 147.1686154 202.9644698 1.379128758 0.463757156 0.411943916 1 5.629585492 8.098361574 10874 neuromedin U "GO:0001659,GO:0001696,GO:0003084,GO:0005102,GO:0005515,GO:0005576,GO:0007186,GO:0007204,GO:0007218,GO:0009648,GO:0010460,GO:0019233,GO:0031652,GO:0031839,GO:0031840,GO:0042755,GO:0042922,GO:0043195,GO:0045187,GO:0045987,GO:0050806,GO:0060455,GO:0097009,GO:0120061,GO:0120069,GO:1902722,GO:1903999,GO:1904058,GO:2000821" "temperature homeostasis|gastric acid secretion|positive regulation of systemic arterial blood pressure|signaling receptor binding|protein binding|extracellular region|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|photoperiodism|positive regulation of heart rate|sensory perception of pain|positive regulation of heat generation|type 1 neuromedin U receptor binding|type 2 neuromedin U receptor binding|eating behavior|neuromedin U receptor binding|terminal bouton|regulation of circadian sleep/wake cycle, sleep|positive regulation of smooth muscle contraction|positive regulation of synaptic transmission|negative regulation of gastric acid secretion|energy homeostasis|negative regulation of gastric emptying|positive regulation of stomach fundus smooth muscle contraction|positive regulation of prolactin secretion|negative regulation of eating behavior|positive regulation of sensory perception of pain|regulation of grooming behavior" hsa04080 Neuroactive ligand-receptor interaction NNMT 222.5522297 160.363043 284.7414164 1.775604971 0.828310653 0.112412145 1 3.562202808 6.597523163 4837 nicotinamide N-methyltransferase "GO:0005829,GO:0008112,GO:0008170,GO:0010243,GO:0030760,GO:0031100,GO:0032259,GO:0034356,GO:0042493" cytosol|nicotinamide N-methyltransferase activity|N-methyltransferase activity|response to organonitrogen compound|pyridine N-methyltransferase activity|animal organ regeneration|methylation|NAD biosynthesis via nicotinamide riboside salvage pathway|response to drug hsa00760 Nicotinate and nicotinamide metabolism NNT 2091.184637 1950.745371 2231.623903 1.143985236 0.194068433 0.546253507 1 14.19109038 16.9337099 23530 nicotinamide nucleotide transhydrogenase "GO:0001933,GO:0003957,GO:0005739,GO:0005743,GO:0005746,GO:0006099,GO:0006740,GO:0008746,GO:0010918,GO:0016020,GO:0016021,GO:0032364,GO:0033273,GO:0043066,GO:0045454,GO:0050661,GO:0051287,GO:0055114,GO:0072593,GO:0098869,GO:1902600,GO:1903285" negative regulation of protein phosphorylation|NAD(P)+ transhydrogenase (B-specific) activity|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|tricarboxylic acid cycle|NADPH regeneration|NAD(P)+ transhydrogenase activity|positive regulation of mitochondrial membrane potential|membrane|integral component of membrane|oxygen homeostasis|response to vitamin|negative regulation of apoptotic process|cell redox homeostasis|NADP binding|NAD binding|oxidation-reduction process|reactive oxygen species metabolic process|cellular oxidant detoxification|proton transmembrane transport|positive regulation of hydrogen peroxide catabolic process hsa00760 Nicotinate and nicotinamide metabolism NOA1 610.5922628 587.6595057 633.5250198 1.07804777 0.108421108 0.783848627 1 13.41879208 15.08923975 84273 nitric oxide associated 1 "GO:0003723,GO:0005515,GO:0005525,GO:0005739,GO:0006915,GO:0010941,GO:0031314,GO:0032543,GO:0043457" RNA binding|protein binding|GTP binding|mitochondrion|apoptotic process|regulation of cell death|extrinsic component of mitochondrial inner membrane|mitochondrial translation|regulation of cellular respiration NOB1 1223.246851 1147.9152 1298.578501 1.131249504 0.17791716 0.602833411 1 33.87986905 39.97753891 28987 NIN1 (RPN12) binding protein 1 homolog "GO:0000469,GO:0004521,GO:0005515,GO:0005654,GO:0005829,GO:0006364,GO:0007601,GO:0030490,GO:0030688,GO:0046872,GO:0090502" "cleavage involved in rRNA processing|endoribonuclease activity|protein binding|nucleoplasm|cytosol|rRNA processing|visual perception|maturation of SSU-rRNA|preribosome, small subunit precursor|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" hsa03008 Ribosome biogenesis in eukaryotes NOC2L 2592.80918 2801.278473 2384.339888 0.851161322 -0.232495501 0.466010803 1 51.45987389 45.68740884 26155 NOC2 like nucleolar associated transcriptional repressor "GO:0000122,GO:0002903,GO:0003682,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006915,GO:0030690,GO:0030691,GO:0031491,GO:0031497,GO:0034644,GO:0035067,GO:0042273,GO:0042393,GO:0070491,GO:1901796,GO:2001243" negative regulation of transcription by RNA polymerase II|negative regulation of B cell apoptotic process|chromatin binding|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|apoptotic process|Noc1p-Noc2p complex|Noc2p-Noc3p complex|nucleosome binding|chromatin assembly|cellular response to UV|negative regulation of histone acetylation|ribosomal large subunit biogenesis|histone binding|repressing transcription factor binding|regulation of signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway NOC3L 1337.720869 1463.566506 1211.875232 0.82802881 -0.27224713 0.418912146 1 18.54966977 16.02129288 64318 NOC3 like DNA replication regulator "GO:0003682,GO:0003723,GO:0005654,GO:0005730,GO:0005739,GO:0006270,GO:0016607,GO:0045444" chromatin binding|RNA binding|nucleoplasm|nucleolus|mitochondrion|DNA replication initiation|nuclear speck|fat cell differentiation NOC4L 461.2437938 481.089129 441.3984586 0.917498301 -0.124222608 0.769664226 1 14.46021793 13.83872364 79050 nucleolar complex associated 4 homolog "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0016021,GO:0030692,GO:0031965,GO:0032040" RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|integral component of membrane|Noc4p-Nop14p complex|nuclear membrane|small-subunit processome NOCT 176.6874538 224.305269 129.0696386 0.575419557 -0.797313839 0.156058071 1 5.790148101 3.475283357 25819 nocturnin "GO:0000175,GO:0000290,GO:0000932,GO:0003729,GO:0004535,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006366,GO:0006739,GO:0007623,GO:0009991,GO:0010629,GO:0016311,GO:0019178,GO:0032496,GO:0032922,GO:0033962,GO:0042752,GO:0045600,GO:0045668,GO:0045995,GO:0046872,GO:0048255,GO:0048471,GO:0090503,GO:0102757" "3'-5'-exoribonuclease activity|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|mRNA binding|poly(A)-specific ribonuclease activity|nucleus|nucleoplasm|cytoplasm|mitochondrion|transcription by RNA polymerase II|NADP metabolic process|circadian rhythm|response to extracellular stimulus|negative regulation of gene expression|dephosphorylation|NADP phosphatase activity|response to lipopolysaccharide|circadian regulation of gene expression|P-body assembly|regulation of circadian rhythm|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|regulation of embryonic development|metal ion binding|mRNA stabilization|perinuclear region of cytoplasm|RNA phosphodiester bond hydrolysis, exonucleolytic|NADPH phosphatase activity" NOD1 292.7084009 241.5595205 343.8572814 1.423488839 0.509431182 0.285626651 1 2.163802183 3.212828552 10392 nucleotide binding oligomerization domain containing 1 "GO:0000187,GO:0002221,GO:0002606,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0006952,GO:0006954,GO:0007165,GO:0007254,GO:0008656,GO:0009595,GO:0010942,GO:0016045,GO:0016323,GO:0016324,GO:0032731,GO:0032755,GO:0032757,GO:0032760,GO:0035556,GO:0038187,GO:0042742,GO:0042802,GO:0042803,GO:0042834,GO:0042981,GO:0043123,GO:0043280,GO:0044877,GO:0045087,GO:0045335,GO:0046330,GO:0046658,GO:0050700,GO:0050830,GO:0051000,GO:0051092,GO:0070374,GO:0070423,GO:0070498,GO:0071225,GO:1901224,GO:1904417" activation of MAPK activity|pattern recognition receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|protein binding|ATP binding|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|defense response|inflammatory response|signal transduction|JNK cascade|cysteine-type endopeptidase activator activity involved in apoptotic process|detection of biotic stimulus|positive regulation of cell death|detection of bacterium|basolateral plasma membrane|apical plasma membrane|positive regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|intracellular signal transduction|pattern recognition receptor activity|defense response to bacterium|identical protein binding|protein homodimerization activity|peptidoglycan binding|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein-containing complex binding|innate immune response|phagocytic vesicle|positive regulation of JNK cascade|anchored component of plasma membrane|CARD domain binding|defense response to Gram-positive bacterium|positive regulation of nitric-oxide synthase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of ERK1 and ERK2 cascade|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|cellular response to muramyl dipeptide|positive regulation of NIK/NF-kappaB signaling|positive regulation of xenophagy "hsa04621,hsa05120,hsa05131,hsa05132,hsa05133" NOD-like receptor signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis NOD2 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.018649391 0.037767322 64127 nucleotide binding oligomerization domain containing 2 "GO:0000187,GO:0002221,GO:0002227,GO:0002253,GO:0002367,GO:0002606,GO:0002710,GO:0002732,GO:0002830,GO:0002862,GO:0002925,GO:0003779,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0006952,GO:0006965,GO:0007254,GO:0007584,GO:0009595,GO:0009986,GO:0016045,GO:0016323,GO:0019899,GO:0019901,GO:0030277,GO:0030544,GO:0031982,GO:0032088,GO:0032495,GO:0032498,GO:0032500,GO:0032689,GO:0032695,GO:0032701,GO:0032703,GO:0032720,GO:0032731,GO:0032733,GO:0032735,GO:0032740,GO:0032755,GO:0032757,GO:0032760,GO:0032874,GO:0032991,GO:0034136,GO:0035556,GO:0038187,GO:0042742,GO:0042834,GO:0043123,GO:0043330,GO:0043406,GO:0043552,GO:0044877,GO:0045087,GO:0045089,GO:0045335,GO:0045747,GO:0045944,GO:0046330,GO:0046645,GO:0046658,GO:0050679,GO:0050700,GO:0050727,GO:0050731,GO:0050766,GO:0050830,GO:0050871,GO:0051092,GO:0051353,GO:0051770,GO:0051879,GO:0060585,GO:0070374,GO:0070423,GO:0070431,GO:0070498,GO:0071222,GO:0071224,GO:0071225,GO:0071407,GO:0071639,GO:0090022,GO:1900017,GO:1901224,GO:1902523,GO:1904417,GO:2000110,GO:2000363" activation of MAPK activity|pattern recognition receptor signaling pathway|innate immune response in mucosa|activation of immune response|cytokine production involved in immune response|positive regulation of dendritic cell antigen processing and presentation|negative regulation of T cell mediated immunity|positive regulation of dendritic cell cytokine production|positive regulation of type 2 immune response|negative regulation of inflammatory response to antigenic stimulus|positive regulation of humoral immune response mediated by circulating immunoglobulin|actin binding|protein binding|ATP binding|cytoplasm|mitochondrion|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|defense response|positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria|JNK cascade|response to nutrient|detection of biotic stimulus|cell surface|detection of bacterium|basolateral plasma membrane|enzyme binding|protein kinase binding|maintenance of gastrointestinal epithelium|Hsp70 protein binding|vesicle|negative regulation of NF-kappaB transcription factor activity|response to muramyl dipeptide|detection of muramyl dipeptide|muramyl dipeptide binding|negative regulation of interferon-gamma production|negative regulation of interleukin-12 production|negative regulation of interleukin-18 production|negative regulation of interleukin-2 production|negative regulation of tumor necrosis factor production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of stress-activated MAPK cascade|protein-containing complex|negative regulation of toll-like receptor 2 signaling pathway|intracellular signal transduction|pattern recognition receptor activity|defense response to bacterium|peptidoglycan binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|positive regulation of MAP kinase activity|positive regulation of phosphatidylinositol 3-kinase activity|protein-containing complex binding|innate immune response|positive regulation of innate immune response|phagocytic vesicle|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of gamma-delta T cell activation|anchored component of plasma membrane|positive regulation of epithelial cell proliferation|CARD domain binding|regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of phagocytosis|defense response to Gram-positive bacterium|positive regulation of B cell activation|positive regulation of NF-kappaB transcription factor activity|positive regulation of oxidoreductase activity|positive regulation of nitric-oxide synthase biosynthetic process|Hsp90 protein binding|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of ERK1 and ERK2 cascade|nucleotide-binding oligomerization domain containing signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|interleukin-1-mediated signaling pathway|cellular response to lipopolysaccharide|cellular response to peptidoglycan|cellular response to muramyl dipeptide|cellular response to organic cyclic compound|positive regulation of monocyte chemotactic protein-1 production|regulation of neutrophil chemotaxis|positive regulation of cytokine production involved in inflammatory response|positive regulation of NIK/NF-kappaB signaling|positive regulation of protein K63-linked ubiquitination|positive regulation of xenophagy|negative regulation of macrophage apoptotic process|positive regulation of prostaglandin-E synthase activity "hsa04621,hsa04668,hsa05152,hsa05321" NOD-like receptor signaling pathway|TNF signaling pathway|Tuberculosis|Inflammatory bowel disease NOG 1100.231813 1225.051854 975.4117724 0.796220804 -0.328759527 0.343308242 1 32.43311797 26.93631316 9241 noggin "GO:0000122,GO:0001501,GO:0001649,GO:0001701,GO:0001706,GO:0001707,GO:0001837,GO:0001839,GO:0001843,GO:0003149,GO:0003151,GO:0003203,GO:0003223,GO:0005515,GO:0005576,GO:0005615,GO:0007399,GO:0008045,GO:0009953,GO:0010628,GO:0019955,GO:0021510,GO:0021533,GO:0021983,GO:0030336,GO:0030509,GO:0030514,GO:0035019,GO:0042060,GO:0042474,GO:0042733,GO:0042803,GO:0045668,GO:0045944,GO:0048318,GO:0048570,GO:0048706,GO:0048712,GO:0050679,GO:0051216,GO:0055009,GO:0060044,GO:0060173,GO:0060272,GO:0060302,GO:0060325,GO:0060394,GO:0060412,GO:0060425,GO:0060513,GO:0060676,GO:0060825,GO:0061037,GO:0061053,GO:0061312,GO:0061384,GO:0061626,GO:0090090,GO:0090190,GO:0090193,GO:1905006,GO:2000313,GO:2001234" negative regulation of transcription by RNA polymerase II|skeletal system development|osteoblast differentiation|in utero embryonic development|endoderm formation|mesoderm formation|epithelial to mesenchymal transition|neural plate morphogenesis|neural tube closure|membranous septum morphogenesis|outflow tract morphogenesis|endocardial cushion morphogenesis|ventricular compact myocardium morphogenesis|protein binding|extracellular region|extracellular space|nervous system development|motor neuron axon guidance|dorsal/ventral pattern formation|positive regulation of gene expression|cytokine binding|spinal cord development|cell differentiation in hindbrain|pituitary gland development|negative regulation of cell migration|BMP signaling pathway|negative regulation of BMP signaling pathway|somatic stem cell population maintenance|wound healing|middle ear morphogenesis|embryonic digit morphogenesis|protein homodimerization activity|negative regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|axial mesoderm development|notochord morphogenesis|embryonic skeletal system development|negative regulation of astrocyte differentiation|positive regulation of epithelial cell proliferation|cartilage development|atrial cardiac muscle tissue morphogenesis|negative regulation of cardiac muscle cell proliferation|limb development|embryonic skeletal joint morphogenesis|negative regulation of cytokine activity|face morphogenesis|negative regulation of pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|lung morphogenesis|prostatic bud formation|ureteric bud formation|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|negative regulation of cartilage development|somite development|BMP signaling pathway involved in heart development|heart trabecula morphogenesis|pharyngeal arch artery morphogenesis|negative regulation of canonical Wnt signaling pathway|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of glomerulus development|negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|negative regulation of apoptotic signaling pathway hsa04350 TGF-beta signaling pathway NOL10 504.2161189 556.1958707 452.2363672 0.813088322 -0.298516021 0.465173021 1 4.817745632 4.085992071 79954 nucleolar protein 10 "GO:0000462,GO:0003723,GO:0005730,GO:0032040" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleolus|small-subunit processome" NOL11 1343.851183 1343.801702 1343.900664 1.000073643 0.000106241 1 1 23.93066651 24.96334082 25926 nucleolar protein 11 "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030490,GO:0034455,GO:1901838" RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|maturation of SSU-rRNA|t-UTP complex|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I NOL12 358.0515731 397.8627396 318.2404065 0.799874869 -0.322153771 0.473454851 1 7.120262963 5.940650663 79159 nucleolar protein 12 "GO:0003723,GO:0005515,GO:0005730,GO:0019843,GO:0042802" RNA binding|protein binding|nucleolus|rRNA binding|identical protein binding NOL3 264.3853894 292.3073189 236.46346 0.808954975 -0.305868687 0.536989752 1 7.186570147 6.06403849 8996 nucleolar protein 3 "GO:0001666,GO:0001974,GO:0002931,GO:0003723,GO:0005123,GO:0005509,GO:0005515,GO:0005730,GO:0005739,GO:0005829,GO:0006376,GO:0008380,GO:0010659,GO:0010667,GO:0010804,GO:0014736,GO:0014808,GO:0014876,GO:0016020,GO:0016529,GO:0035877,GO:0042802,GO:0043027,GO:0043066,GO:0051259,GO:0060547,GO:0089720,GO:0090201,GO:0097193,GO:1901222,GO:1902109,GO:1902176,GO:1903298,GO:1990001,GO:2001237" response to hypoxia|blood vessel remodeling|response to ischemia|RNA binding|death receptor binding|calcium ion binding|protein binding|nucleolus|mitochondrion|cytosol|mRNA splice site selection|RNA splicing|cardiac muscle cell apoptotic process|negative regulation of cardiac muscle cell apoptotic process|negative regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of muscle atrophy|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to injury involved in regulation of muscle adaptation|membrane|sarcoplasmic reticulum|death effector domain binding|identical protein binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|protein complex oligomerization|negative regulation of necrotic cell death|caspase binding|negative regulation of release of cytochrome c from mitochondria|intrinsic apoptotic signaling pathway|regulation of NIK/NF-kappaB signaling|negative regulation of mitochondrial membrane permeability involved in apoptotic process|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|inhibition of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of extrinsic apoptotic signaling pathway NOL4L 2102.065599 2155.766477 2048.364722 0.950179319 -0.073728289 0.819600028 1 11.51587037 11.41348495 140688 nucleolar protein 4 like "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol NOL6 1864.384786 2072.540087 1656.229484 0.799130253 -0.323497423 0.318201065 1 19.45271385 16.21487856 65083 nucleolar protein 6 "GO:0000794,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0006364,GO:0006409,GO:0032040,GO:0032545,GO:0034456" condensed nuclear chromosome|RNA binding|protein binding|nucleoplasm|nucleolus|mitochondrion|rRNA processing|tRNA export from nucleus|small-subunit processome|CURI complex|UTP-C complex hsa03008 Ribosome biogenesis in eukaryotes NOL7 672.9378259 707.42431 638.4513419 0.902501275 -0.147999124 0.699955383 1 20.34556823 19.15285751 51406 nucleolar protein 7 "GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0005739" RNA binding|protein binding|chromosome|nucleolus|mitochondrion NOL8 646.4868661 684.0803227 608.8934094 0.890090519 -0.167976035 0.664213812 1 6.756289987 6.272755884 55035 nucleolar protein 8 "GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0006364,GO:1902570" RNA binding|protein binding|chromosome|nucleolus|rRNA processing|protein localization to nucleolus NOL9 603.954471 706.409354 501.499588 0.709927728 -0.494255931 0.2056162 1 4.576252458 3.388754007 79707 nucleolar protein 9 "GO:0000448,GO:0000460,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0006396,GO:0016020,GO:0016310,GO:0045111,GO:0051731" "cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|rRNA processing|RNA processing|membrane|phosphorylation|intermediate filament cytoskeleton|polynucleotide 5'-hydroxyl-kinase activity" NOLC1 5907.524721 6997.106446 4817.942997 0.688562198 -0.538341115 0.097319539 1 94.62717148 67.96337931 9221 nucleolar and coiled-body phosphoprotein 1 "GO:0000278,GO:0001650,GO:0003677,GO:0003700,GO:0003723,GO:0005515,GO:0005524,GO:0005525,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0006417,GO:0006970,GO:0007000,GO:0008134,GO:0008139,GO:0008284,GO:0014029,GO:0014032,GO:0015030,GO:0019904,GO:0030674,GO:0031428,GO:0031429,GO:0033979,GO:0034512,GO:0034513,GO:0042306,GO:0045893,GO:0046982,GO:0062064,GO:0062065" "mitotic cell cycle|fibrillar center|DNA binding|DNA-binding transcription factor activity|RNA binding|protein binding|ATP binding|GTP binding|nucleoplasm|nucleolus|cytoplasm|rRNA processing|regulation of translation|response to osmotic stress|nucleolus organization|transcription factor binding|nuclear localization sequence binding|positive regulation of cell population proliferation|neural crest formation|neural crest cell development|Cajal body|protein domain specific binding|protein-macromolecule adaptor activity|box C/D RNP complex|box H/ACA snoRNP complex|box H/ACA RNA metabolic process|box C/D RNA binding|box H/ACA snoRNA binding|regulation of protein import into nucleus|positive regulation of transcription, DNA-templated|protein heterodimerization activity|box C/D snoRNP complex binding|box H/ACA snoRNP complex binding" NOM1 915.8809713 880.9817805 950.780162 1.079227951 0.109999618 0.76074202 1 7.332558631 8.254383809 64434 nucleolar protein with MIF4G domain 1 "GO:0003723,GO:0005515,GO:0005730,GO:0008150,GO:0042274,GO:0048820" RNA binding|protein binding|nucleolus|biological_process|ribosomal small subunit biogenesis|hair follicle maturation NOMO1 2080.168333 2309.024828 1851.311839 0.801772166 -0.31873576 0.321484241 1 27.12058483 22.68119622 23420 NODAL modulator 1 "GO:0003674,GO:0005515,GO:0005575,GO:0005789,GO:0008150,GO:0016020,GO:0016021,GO:0030246,GO:1900108" molecular_function|protein binding|cellular_component|endoplasmic reticulum membrane|biological_process|membrane|integral component of membrane|carbohydrate binding|negative regulation of nodal signaling pathway NOMO2 904.3411058 1068.748635 739.9335768 0.692336395 -0.530454905 0.139533546 1 12.17461719 8.79201472 283820 NODAL modulator 2 "GO:0005515,GO:0005789,GO:0016021,GO:0030246,GO:0032991" protein binding|endoplasmic reticulum membrane|integral component of membrane|carbohydrate binding|protein-containing complex NOMO3 70.17101701 82.21143344 58.13060058 0.707086571 -0.500041235 0.517217138 1 1.04380022 0.769849626 408050 NODAL modulator 3 "GO:0003674,GO:0005515,GO:0005575,GO:0005789,GO:0008150,GO:0016021,GO:0030246,GO:1900108" molecular_function|protein binding|cellular_component|endoplasmic reticulum membrane|biological_process|integral component of membrane|carbohydrate binding|negative regulation of nodal signaling pathway NONO 15594.83897 14891.43397 16298.24398 1.094471091 0.130233848 0.711449031 1 271.7832781 310.2722656 4841 non-POU domain containing octamer binding "GO:0000398,GO:0000976,GO:0001650,GO:0002218,GO:0003676,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0006355,GO:0006397,GO:0007623,GO:0008380,GO:0016020,GO:0016363,GO:0016607,GO:0042382,GO:0042752,GO:0042802,GO:0045087,GO:0045892,GO:0090575,GO:1903377" "mRNA splicing, via spliceosome|transcription regulatory region sequence-specific DNA binding|fibrillar center|activation of innate immune response|nucleic acid binding|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|DNA repair|DNA recombination|regulation of transcription, DNA-templated|mRNA processing|circadian rhythm|RNA splicing|membrane|nuclear matrix|nuclear speck|paraspeckles|regulation of circadian rhythm|identical protein binding|innate immune response|negative regulation of transcription, DNA-templated|RNA polymerase II transcription regulator complex|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway" NOP10 1719.748117 1850.26473 1589.231504 0.858921147 -0.219402404 0.501913746 1 184.8311267 165.5939005 55505 NOP10 ribonucleoprotein "GO:0000454,GO:0001522,GO:0003723,GO:0005515,GO:0005654,GO:0005697,GO:0005732,GO:0007004,GO:0016604,GO:0031118,GO:0031120,GO:0031429,GO:0034513,GO:0070034,GO:0072589,GO:0090661,GO:1904874" snoRNA guided rRNA pseudouridine synthesis|pseudouridine synthesis|RNA binding|protein binding|nucleoplasm|telomerase holoenzyme complex|sno(s)RNA-containing ribonucleoprotein complex|telomere maintenance via telomerase|nuclear body|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis|box H/ACA snoRNP complex|box H/ACA snoRNA binding|telomerase RNA binding|box H/ACA scaRNP complex|box H/ACA telomerase RNP complex|positive regulation of telomerase RNA localization to Cajal body hsa03008 Ribosome biogenesis in eukaryotes NOP14 967.5937451 1048.449515 886.7379749 0.845761252 -0.241677629 0.495988081 1 14.93258415 13.17342445 8602 NOP14 nucleolar protein "GO:0000447,GO:0000462,GO:0000472,GO:0000480,GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0016020,GO:0019899,GO:0030490,GO:0030515,GO:0030686,GO:0030692,GO:0032040,GO:0042274" "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|nucleolus|rRNA processing|membrane|enzyme binding|maturation of SSU-rRNA|snoRNA binding|90S preribosome|Noc4p-Nop14p complex|small-subunit processome|ribosomal small subunit biogenesis" NOP16 491.9421294 592.7342855 391.1499734 0.659907792 -0.599663643 0.144127106 1 30.66384119 21.10696271 51491 NOP16 nucleolar protein "GO:0003723,GO:0005654,GO:0005730,GO:0042273,GO:0043231" RNA binding|nucleoplasm|nucleolus|ribosomal large subunit biogenesis|intracellular membrane-bounded organelle NOP2 1235.092788 1418.908444 1051.277132 0.740905544 -0.432638466 0.204083494 1 24.45141445 18.89656045 4839 NOP2 nucleolar protein "GO:0000027,GO:0000470,GO:0001510,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006357,GO:0008284,GO:0009383,GO:0070475,GO:1901796" ribosomal large subunit assembly|maturation of LSU-rRNA|RNA methylation|RNA binding|protein binding|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|rRNA (cytosine-C5-)-methyltransferase activity|rRNA base methylation|regulation of signal transduction by p53 class mediator NOP53 3250.352928 2995.135063 3505.570794 1.170421607 0.227028309 0.475499884 1 100.8597239 123.1334465 29997 NOP53 ribosome biogenesis factor "GO:0000027,GO:0000122,GO:0001650,GO:0001932,GO:0002039,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006281,GO:0006364,GO:0006974,GO:0007095,GO:0008097,GO:0014067,GO:0016032,GO:0031333,GO:0032435,GO:0032436,GO:0033553,GO:0039535,GO:0042802,GO:0042981,GO:0043231,GO:0050821,GO:0051726,GO:0051898,GO:0071456,GO:1901796,GO:1901797,GO:1901837,GO:1902570,GO:1903006,GO:1903715,GO:1990173" ribosomal large subunit assembly|negative regulation of transcription by RNA polymerase II|fibrillar center|regulation of protein phosphorylation|p53 binding|RNA binding|protein binding|nucleoplasm|nucleolus|cytosol|DNA repair|rRNA processing|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|5S rRNA binding|negative regulation of phosphatidylinositol 3-kinase signaling|viral process|negative regulation of protein-containing complex assembly|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|rDNA heterochromatin|regulation of RIG-I signaling pathway|identical protein binding|regulation of apoptotic process|intracellular membrane-bounded organelle|protein stabilization|regulation of cell cycle|negative regulation of protein kinase B signaling|cellular response to hypoxia|regulation of signal transduction by p53 class mediator|negative regulation of signal transduction by p53 class mediator|negative regulation of transcription of nucleolar large rRNA by RNA polymerase I|protein localization to nucleolus|positive regulation of protein K63-linked deubiquitination|regulation of aerobic respiration|protein localization to nucleoplasm NOP56 3637.404483 4196.842929 3077.966037 0.733400341 -0.447327157 0.160239201 1 111.1109717 84.99903263 10528 NOP56 ribonucleoprotein "GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005732,GO:0005737,GO:0006364,GO:0016020,GO:0030515,GO:0031428,GO:0032040,GO:0045296,GO:0070761,GO:1990226" fibrillar center|RNA binding|protein binding|nucleoplasm|nucleolus|sno(s)RNA-containing ribonucleoprotein complex|cytoplasm|rRNA processing|membrane|snoRNA binding|box C/D RNP complex|small-subunit processome|cadherin binding|pre-snoRNP complex|histone methyltransferase binding "hsa03008,hsa05017" Ribosome biogenesis in eukaryotes|Spinocerebellar ataxia NOP58 1080.185072 1201.707867 958.6622773 0.797749856 -0.325991652 0.348849847 1 30.52270014 25.39835646 51602 NOP58 ribonucleoprotein "GO:0001094,GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005732,GO:0005829,GO:0006364,GO:0015030,GO:0016020,GO:0030515,GO:0031428,GO:0032040,GO:0048254,GO:0051117,GO:0070761" TFIID-class transcription factor complex binding|fibrillar center|RNA binding|protein binding|nucleoplasm|nucleolus|sno(s)RNA-containing ribonucleoprotein complex|cytosol|rRNA processing|Cajal body|membrane|snoRNA binding|box C/D RNP complex|small-subunit processome|snoRNA localization|ATPase binding|pre-snoRNP complex hsa03008 Ribosome biogenesis in eukaryotes NOP9 1660.666149 1616.824858 1704.507441 1.054231343 0.07619149 0.817554884 1 15.68105615 17.24356917 161424 NOP9 nucleolar protein "GO:0000056,GO:0000447,GO:0000472,GO:0000480,GO:0003723,GO:0005575,GO:0005730,GO:0008150,GO:0030686,GO:0030688" "ribosomal small subunit export from nucleus|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|cellular_component|nucleolus|biological_process|90S preribosome|preribosome, small subunit precursor" NOPCHAP1 185.2876096 206.0360616 164.5391576 0.798593976 -0.324465906 0.560749508 1 0.443589511 0.369507475 121053 NOP protein chaperone 1 NOS1AP 62.51430992 63.94222601 61.08639383 0.955337304 -0.065917894 0.955236895 1 0.435450877 0.433922166 9722 nitric oxide synthase 1 adaptor protein "GO:0003062,GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0005901,GO:0010628,GO:0010750,GO:0030018,GO:0030315,GO:0031965,GO:0033017,GO:0042383,GO:0045428,GO:0045429,GO:0048471,GO:0050998,GO:0050999,GO:0051000,GO:0060307,GO:0098901,GO:0098974,GO:0098978,GO:1901381,GO:1901841,GO:1902261,GO:1902514,GO:1902937,GO:1903762,GO:1990454,GO:2000170" regulation of heart rate by chemical signal|protein binding|nucleus|mitochondrion|cytosol|caveola|positive regulation of gene expression|positive regulation of nitric oxide mediated signal transduction|Z disc|T-tubule|nuclear membrane|sarcoplasmic reticulum membrane|sarcolemma|regulation of nitric oxide biosynthetic process|positive regulation of nitric oxide biosynthetic process|perinuclear region of cytoplasm|nitric-oxide synthase binding|regulation of nitric-oxide synthase activity|positive regulation of nitric-oxide synthase activity|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of cardiac muscle cell action potential|postsynaptic actin cytoskeleton organization|glutamatergic synapse|positive regulation of potassium ion transmembrane transport|regulation of high voltage-gated calcium channel activity|positive regulation of delayed rectifier potassium channel activity|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|inward rectifier potassium channel complex|positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|L-type voltage-gated calcium channel complex|positive regulation of peptidyl-cysteine S-nitrosylation hsa04713 Circadian entrainment NOSIP 1412.648224 1433.117827 1392.178621 0.971433468 -0.041812904 0.902438308 1 41.78604618 42.34091815 51070 nitric oxide synthase interacting protein "GO:0000139,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007275,GO:0016567,GO:0043086,GO:0050999,GO:0051001,GO:0061630" Golgi membrane|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|multicellular organism development|protein ubiquitination|negative regulation of catalytic activity|regulation of nitric-oxide synthase activity|negative regulation of nitric-oxide synthase activity|ubiquitin protein ligase activity NOTCH1 790.2058183 809.9348628 770.4767737 0.951282392 -0.07205442 0.847864759 1 4.307502207 4.274161191 4851 notch receptor 1 "GO:0000122,GO:0000139,GO:0001669,GO:0001701,GO:0001708,GO:0001837,GO:0001889,GO:0001947,GO:0002040,GO:0002052,GO:0002193,GO:0002437,GO:0003151,GO:0003157,GO:0003160,GO:0003162,GO:0003169,GO:0003180,GO:0003181,GO:0003182,GO:0003184,GO:0003192,GO:0003198,GO:0003203,GO:0003207,GO:0003208,GO:0003209,GO:0003213,GO:0003214,GO:0003219,GO:0003222,GO:0003241,GO:0003252,GO:0003256,GO:0003270,GO:0003273,GO:0003332,GO:0003344,GO:0003713,GO:0004857,GO:0004888,GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005789,GO:0005829,GO:0005886,GO:0005912,GO:0006355,GO:0006367,GO:0006955,GO:0006959,GO:0007050,GO:0007219,GO:0007221,GO:0007283,GO:0007368,GO:0007386,GO:0007411,GO:0007440,GO:0007492,GO:0007507,GO:0008284,GO:0008285,GO:0009912,GO:0009986,GO:0010614,GO:0010628,GO:0010629,GO:0010812,GO:0010832,GO:0014031,GO:0014807,GO:0016021,GO:0016324,GO:0019899,GO:0021515,GO:0021915,GO:0030216,GO:0030279,GO:0030324,GO:0030335,GO:0030513,GO:0030514,GO:0030900,GO:0031069,GO:0031100,GO:0031490,GO:0031960,GO:0032495,GO:0032496,GO:0035116,GO:0035148,GO:0035914,GO:0035924,GO:0042246,GO:0042802,GO:0043086,GO:0043235,GO:0045070,GO:0045603,GO:0045608,GO:0045618,GO:0045662,GO:0045668,GO:0045747,GO:0045892,GO:0045893,GO:0045944,GO:0045955,GO:0045967,GO:0046427,GO:0046533,GO:0046579,GO:0048103,GO:0048708,GO:0048709,GO:0048711,GO:0048715,GO:0048754,GO:0048873,GO:0050679,GO:0050768,GO:0055008,GO:0060038,GO:0060045,GO:0060253,GO:0060271,GO:0060317,GO:0060354,GO:0060411,GO:0060412,GO:0060528,GO:0060740,GO:0060768,GO:0060842,GO:0060843,GO:0060948,GO:0060956,GO:0060979,GO:0060982,GO:0061314,GO:0061384,GO:0061419,GO:0062043,GO:0070168,GO:0070374,GO:0070986,GO:0071372,GO:0072017,GO:0072044,GO:0072144,GO:0090051,GO:0090090,GO:0097150,GO:0120163,GO:1901201,GO:1902263,GO:1902339,GO:1903849,GO:2000048,GO:2000737,GO:2000811,GO:2000974,GO:2001027" "negative regulation of transcription by RNA polymerase II|Golgi membrane|acrosomal vesicle|in utero embryonic development|cell fate specification|epithelial to mesenchymal transition|liver development|heart looping|sprouting angiogenesis|positive regulation of neuroblast proliferation|MAML1-RBP-Jkappa- ICN1 complex|inflammatory response to antigenic stimulus|outflow tract morphogenesis|endocardium development|endocardium morphogenesis|atrioventricular node development|coronary vein morphogenesis|aortic valve morphogenesis|atrioventricular valve morphogenesis|coronary sinus valve morphogenesis|pulmonary valve morphogenesis|mitral valve formation|epithelial to mesenchymal transition involved in endocardial cushion formation|endocardial cushion morphogenesis|cardiac chamber formation|cardiac ventricle morphogenesis|cardiac atrium morphogenesis|cardiac right atrium morphogenesis|cardiac left ventricle morphogenesis|cardiac right ventricle formation|ventricular trabecula myocardium morphogenesis|growth involved in heart morphogenesis|negative regulation of cell proliferation involved in heart valve morphogenesis|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation|cell migration involved in endocardial cushion formation|negative regulation of extracellular matrix constituent secretion|pericardium morphogenesis|transcription coactivator activity|enzyme inhibitor activity|transmembrane signaling receptor activity|Notch binding|calcium ion binding|protein binding|extracellular region|nucleus|nucleoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|adherens junction|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|immune response|humoral immune response|cell cycle arrest|Notch signaling pathway|positive regulation of transcription of Notch receptor target|spermatogenesis|determination of left/right symmetry|compartment pattern specification|axon guidance|foregut morphogenesis|endoderm development|heart development|positive regulation of cell population proliferation|negative regulation of cell population proliferation|auditory receptor cell fate commitment|cell surface|negative regulation of cardiac muscle hypertrophy|positive regulation of gene expression|negative regulation of gene expression|negative regulation of cell-substrate adhesion|negative regulation of myotube differentiation|mesenchymal cell development|regulation of somitogenesis|integral component of membrane|apical plasma membrane|enzyme binding|cell differentiation in spinal cord|neural tube development|keratinocyte differentiation|negative regulation of ossification|lung development|positive regulation of cell migration|positive regulation of BMP signaling pathway|negative regulation of BMP signaling pathway|forebrain development|hair follicle morphogenesis|animal organ regeneration|chromatin DNA binding|response to corticosteroid|response to muramyl dipeptide|response to lipopolysaccharide|embryonic hindlimb morphogenesis|tube formation|skeletal muscle cell differentiation|cellular response to vascular endothelial growth factor stimulus|tissue regeneration|identical protein binding|negative regulation of catalytic activity|receptor complex|positive regulation of viral genome replication|positive regulation of endothelial cell differentiation|negative regulation of inner ear auditory receptor cell differentiation|positive regulation of keratinocyte differentiation|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of calcium ion-dependent exocytosis|negative regulation of growth rate|positive regulation of receptor signaling pathway via JAK-STAT|negative regulation of photoreceptor cell differentiation|positive regulation of Ras protein signal transduction|somatic stem cell division|astrocyte differentiation|oligodendrocyte differentiation|positive regulation of astrocyte differentiation|negative regulation of oligodendrocyte differentiation|branching morphogenesis of an epithelial tube|homeostasis of number of cells within a tissue|positive regulation of epithelial cell proliferation|negative regulation of neurogenesis|cardiac muscle tissue morphogenesis|cardiac muscle cell proliferation|positive regulation of cardiac muscle cell proliferation|negative regulation of glial cell proliferation|cilium assembly|cardiac epithelial to mesenchymal transition|negative regulation of cell adhesion molecule production|cardiac septum morphogenesis|ventricular septum morphogenesis|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|prostate gland epithelium morphogenesis|regulation of epithelial cell proliferation involved in prostate gland development|arterial endothelial cell differentiation|venous endothelial cell differentiation|cardiac vascular smooth muscle cell development|endocardial cell differentiation|vasculogenesis involved in coronary vascular morphogenesis|coronary artery morphogenesis|Notch signaling involved in heart development|heart trabecula morphogenesis|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of cardiac epithelial to mesenchymal transition|negative regulation of biomineral tissue development|positive regulation of ERK1 and ERK2 cascade|left/right axis specification|cellular response to follicle-stimulating hormone stimulus|distal tubule development|collecting duct development|glomerular mesangial cell development|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of canonical Wnt signaling pathway|neuronal stem cell population maintenance|negative regulation of cold-induced thermogenesis|regulation of extracellular matrix assembly|apoptotic process involved in embryonic digit morphogenesis|positive regulation of apoptotic process involved in morphogenesis|positive regulation of aorta morphogenesis|negative regulation of cell-cell adhesion mediated by cadherin|negative regulation of stem cell differentiation|negative regulation of anoikis|negative regulation of pro-B cell differentiation|negative regulation of endothelial cell chemotaxis" "hsa01522,hsa04330,hsa04658,hsa04919,hsa05020,hsa05165,hsa05200,hsa05206,hsa05224" Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Thyroid hormone signaling pathway|Prion disease|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Breast cancer other NOTCH2 10143.44195 9608.588153 10678.29575 1.11132828 0.152285044 0.651293928 1 41.2967662 47.87120292 4853 notch receptor 2 "GO:0000122,GO:0000139,GO:0001701,GO:0001709,GO:0001947,GO:0002011,GO:0002315,GO:0002437,GO:0003184,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005789,GO:0005886,GO:0005887,GO:0005929,GO:0006367,GO:0006915,GO:0006959,GO:0007050,GO:0007219,GO:0007275,GO:0007399,GO:0007411,GO:0009887,GO:0009986,GO:0010629,GO:0010838,GO:0016020,GO:0019827,GO:0019899,GO:0030097,GO:0030326,GO:0030513,GO:0035264,GO:0035622,GO:0038023,GO:0042060,GO:0042742,GO:0043011,GO:0043065,GO:0043066,GO:0043235,GO:0045672,GO:0045967,GO:0046579,GO:0046849,GO:0051059,GO:0060413,GO:0060674,GO:0061073,GO:0061314,GO:0070374,GO:0070986,GO:0072014,GO:0072015,GO:0072104,GO:0072574,GO:1990705,GO:2000249,GO:2001204" negative regulation of transcription by RNA polymerase II|Golgi membrane|in utero embryonic development|cell fate determination|heart looping|morphogenesis of an epithelial sheet|marginal zone B cell differentiation|inflammatory response to antigenic stimulus|pulmonary valve morphogenesis|calcium ion binding|protein binding|extracellular region|nucleus|nucleoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cilium|transcription initiation from RNA polymerase II promoter|apoptotic process|humoral immune response|cell cycle arrest|Notch signaling pathway|multicellular organism development|nervous system development|axon guidance|animal organ morphogenesis|cell surface|negative regulation of gene expression|positive regulation of keratinocyte proliferation|membrane|stem cell population maintenance|enzyme binding|hemopoiesis|embryonic limb morphogenesis|positive regulation of BMP signaling pathway|multicellular organism growth|intrahepatic bile duct development|signaling receptor activity|wound healing|defense response to bacterium|myeloid dendritic cell differentiation|positive regulation of apoptotic process|negative regulation of apoptotic process|receptor complex|positive regulation of osteoclast differentiation|negative regulation of growth rate|positive regulation of Ras protein signal transduction|bone remodeling|NF-kappaB binding|atrial septum morphogenesis|placenta blood vessel development|ciliary body morphogenesis|Notch signaling involved in heart development|positive regulation of ERK1 and ERK2 cascade|left/right axis specification|proximal tubule development|glomerular visceral epithelial cell development|glomerular capillary formation|hepatocyte proliferation|cholangiocyte proliferation|regulation of actin cytoskeleton reorganization|regulation of osteoclast development "hsa01522,hsa04330,hsa04658,hsa04919,hsa05165,hsa05200,hsa05206,hsa05224" Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Thyroid hormone signaling pathway|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Breast cancer NOTCH2NLA 251.9414154 216.1856213 287.6972096 1.330787903 0.412280657 0.411083664 1 2.056543775 2.854714839 388677 notch 2 N-terminal like A "GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0007219,GO:0021987,GO:0030154,GO:0045747" Notch binding|calcium ion binding|protein binding|extracellular region|cytoplasm|Notch signaling pathway|cerebral cortex development|cell differentiation|positive regulation of Notch signaling pathway NOTCH2NLB 174.1555071 152.2433953 196.0676189 1.287856321 0.364971649 0.520805215 1 0.705258473 0.947396239 100996763 notch 2 N-terminal like B "GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0007219,GO:0021987,GO:0045747" Notch binding|calcium ion binding|protein binding|extracellular region|Notch signaling pathway|cerebral cortex development|positive regulation of Notch signaling pathway NOTCH2NLC 137.1635541 149.1985274 125.1285809 0.838671689 -0.253821939 0.684421077 1 0.864871131 0.756587764 100996717 notch 2 N-terminal like C "GO:0005509,GO:0005515,GO:0005576,GO:0007219,GO:0021987,GO:0045747" calcium ion binding|protein binding|extracellular region|Notch signaling pathway|cerebral cortex development|positive regulation of Notch signaling pathway NOTCH4 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.038105218 0.023150332 4855 notch receptor 4 "GO:0000122,GO:0000139,GO:0001569,GO:0001709,GO:0001763,GO:0001837,GO:0001886,GO:0001944,GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005789,GO:0005829,GO:0005886,GO:0005887,GO:0006367,GO:0007221,GO:0009986,GO:0030097,GO:0030154,GO:0030879,GO:0035278,GO:0038023,GO:0042060,GO:0045596,GO:0045602,GO:0045747,GO:0045893,GO:0060354,GO:2000048" "negative regulation of transcription by RNA polymerase II|Golgi membrane|branching involved in blood vessel morphogenesis|cell fate determination|morphogenesis of a branching structure|epithelial to mesenchymal transition|endothelial cell morphogenesis|vasculature development|Notch binding|calcium ion binding|protein binding|extracellular region|nucleus|nucleoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|integral component of plasma membrane|transcription initiation from RNA polymerase II promoter|positive regulation of transcription of Notch receptor target|cell surface|hemopoiesis|cell differentiation|mammary gland development|miRNA mediated inhibition of translation|signaling receptor activity|wound healing|negative regulation of cell differentiation|negative regulation of endothelial cell differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription, DNA-templated|negative regulation of cell adhesion molecule production|negative regulation of cell-cell adhesion mediated by cadherin" "hsa01522,hsa04330,hsa04919,hsa05165,hsa05200,hsa05206,hsa05224" Endocrine resistance|Notch signaling pathway|Thyroid hormone signaling pathway|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Breast cancer NOTUM 20.58391071 26.38885518 14.77896625 0.560045752 -0.836383404 0.459814859 1 0.601215664 0.351212306 147111 "notum, palmitoleoyl-protein carboxylesterase" "GO:0004629,GO:0005515,GO:0005576,GO:0005788,GO:0016055,GO:0030178,GO:0043687,GO:0044267,GO:0090090,GO:1990697,GO:1990699" phospholipase C activity|protein binding|extracellular region|endoplasmic reticulum lumen|Wnt signaling pathway|negative regulation of Wnt signaling pathway|post-translational protein modification|cellular protein metabolic process|negative regulation of canonical Wnt signaling pathway|protein depalmitoleylation|palmitoleyl hydrolase activity hsa04310 Wnt signaling pathway NOVA2 35.63282253 11.16451565 60.10112941 5.383227655 2.428471438 0.014294039 0.528337145 0.067467287 0.378836593 4858 NOVA alternative splicing regulator 2 "GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0010468,GO:0051252,GO:0120163" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|cytoplasm|regulation of gene expression|regulation of RNA metabolic process|negative regulation of cold-induced thermogenesis" NOX3 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.129807927 0.131438545 50508 NADPH oxidase 3 "GO:0001659,GO:0005515,GO:0005737,GO:0005886,GO:0006952,GO:0009590,GO:0016175,GO:0042554,GO:0043020,GO:0048840,GO:0055114,GO:0070062" temperature homeostasis|protein binding|cytoplasm|plasma membrane|defense response|detection of gravity|superoxide-generating NAD(P)H oxidase activity|superoxide anion generation|NADPH oxidase complex|otolith development|oxidation-reduction process|extracellular exosome NOX5 9.538161268 12.17947162 6.896850916 0.566268483 -0.82044186 0.599184136 1 0.071743111 0.04237586 79400 NADPH oxidase 5 "GO:0000293,GO:0001525,GO:0001816,GO:0001935,GO:0005509,GO:0005789,GO:0005886,GO:0006915,GO:0015252,GO:0016021,GO:0016175,GO:0020037,GO:0033215,GO:0034599,GO:0042554,GO:0043012,GO:0050660,GO:0050661,GO:0055114,GO:0061640,GO:1902600" ferric-chelate reductase activity|angiogenesis|cytokine production|endothelial cell proliferation|calcium ion binding|endoplasmic reticulum membrane|plasma membrane|apoptotic process|proton channel activity|integral component of membrane|superoxide-generating NAD(P)H oxidase activity|heme binding|reductive iron assimilation|cellular response to oxidative stress|superoxide anion generation|regulation of fusion of sperm to egg plasma membrane|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process|cytoskeleton-dependent cytokinesis|proton transmembrane transport NOXA1 61.5290455 63.94222601 59.11586499 0.924519972 -0.113223609 0.906823271 1 1.371642597 1.322736054 10811 NADPH oxidase activator 1 "GO:0005515,GO:0005829,GO:0006801,GO:0010310,GO:0016176,GO:0017124,GO:0019899,GO:0031267,GO:0042554,GO:0043020,GO:0050790,GO:0060263" protein binding|cytosol|superoxide metabolic process|regulation of hydrogen peroxide metabolic process|superoxide-generating NADPH oxidase activator activity|SH3 domain binding|enzyme binding|small GTPase binding|superoxide anion generation|NADPH oxidase complex|regulation of catalytic activity|regulation of respiratory burst NOXRED1 11.47899855 10.14955968 12.80843742 1.261969762 0.335677342 0.860335721 1 0.167221663 0.220118942 122945 NADP dependent oxidoreductase domain containing 1 "GO:0003674,GO:0004735,GO:0005575,GO:0008150,GO:0055114,GO:0055129" molecular_function|pyrroline-5-carboxylate reductase activity|cellular_component|biological_process|oxidation-reduction process|L-proline biosynthetic process NPAS1 10.50857991 11.16451565 9.852644165 0.882496337 -0.180337805 0.971696509 1 0.22626784 0.208281968 4861 neuronal PAS domain protein 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001964,GO:0003700,GO:0005634,GO:0006357,GO:0007417,GO:0042711,GO:0045892,GO:0046982" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|startle response|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|maternal behavior|negative regulation of transcription, DNA-templated|protein heterodimerization activity" NPAS2 1667.090411 1921.311648 1412.869173 0.735366995 -0.443463668 0.175940024 1 11.21960763 8.605928486 4862 neuronal PAS domain protein 2 "GO:0000785,GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0006974,GO:0007417,GO:0007623,GO:0019216,GO:0032922,GO:0042493,GO:0045739,GO:0045893,GO:0045944,GO:0046872,GO:0046983,GO:0051775,GO:0051879,GO:0060548,GO:1990513,GO:1990837,GO:2000987,GO:2001020" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|central nervous system development|circadian rhythm|regulation of lipid metabolic process|circadian regulation of gene expression|response to drug|positive regulation of DNA repair|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|protein dimerization activity|response to redox state|Hsp90 protein binding|negative regulation of cell death|CLOCK-BMAL transcription complex|sequence-specific double-stranded DNA binding|positive regulation of behavioral fear response|regulation of response to DNA damage stimulus" hsa04710 Circadian rhythm NPAT 998.0142165 905.3407238 1090.687709 1.204726221 0.268705326 0.44640196 1 4.948447422 6.218322655 4863 "nuclear protein, coactivator of histone transcription" "GO:0000083,GO:0001701,GO:0003712,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008022,GO:0010468,GO:0015030,GO:0045892,GO:0045893,GO:0045944,GO:0097504" "regulation of transcription involved in G1/S transition of mitotic cell cycle|in utero embryonic development|transcription coregulator activity|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein C-terminus binding|regulation of gene expression|Cajal body|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|Gemini of coiled bodies" other NPB 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.089398155 0.271563463 256933 neuropeptide B "GO:0001664,GO:0005515,GO:0005576,GO:0007186,GO:0007218,GO:0007631" G protein-coupled receptor binding|protein binding|extracellular region|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|feeding behavior hsa04080 Neuroactive ligand-receptor interaction NPBWR1 3.552345889 7.104691779 0 0 #NAME? 0.089820349 1 0.085490039 0 2831 neuropeptides B and W receptor 1 "GO:0004930,GO:0004985,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0007218,GO:0007268,GO:0008188,GO:0016021,GO:0019222,GO:0038003,GO:0042277,GO:0042923,GO:0043005,GO:0045202" G protein-coupled receptor activity|opioid receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|neuropeptide receptor activity|integral component of membrane|regulation of metabolic process|opioid receptor signaling pathway|peptide binding|neuropeptide binding|neuron projection|synapse hsa04080 Neuroactive ligand-receptor interaction NPC1 2964.455025 2713.992259 3214.917791 1.184571467 0.244365241 0.442631677 1 18.38113581 22.71169466 4864 NPC intracellular cholesterol transporter 1 "GO:0001618,GO:0004888,GO:0005515,GO:0005576,GO:0005635,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005887,GO:0006486,GO:0006897,GO:0006914,GO:0007041,GO:0007628,GO:0008203,GO:0008206,GO:0015248,GO:0015485,GO:0016020,GO:0016021,GO:0016242,GO:0030301,GO:0031579,GO:0031902,GO:0032367,GO:0033344,GO:0034383,GO:0038023,GO:0042493,GO:0042632,GO:0045121,GO:0046686,GO:0046718,GO:0048471,GO:0060548,GO:0070062,GO:0071383,GO:0071404,GO:0090150,GO:1905103" virus receptor activity|transmembrane signaling receptor activity|protein binding|extracellular region|nuclear envelope|lysosome|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|integral component of plasma membrane|protein glycosylation|endocytosis|autophagy|lysosomal transport|adult walking behavior|cholesterol metabolic process|bile acid metabolic process|sterol transporter activity|cholesterol binding|membrane|integral component of membrane|negative regulation of macroautophagy|cholesterol transport|membrane raft organization|late endosome membrane|intracellular cholesterol transport|cholesterol efflux|low-density lipoprotein particle clearance|signaling receptor activity|response to drug|cholesterol homeostasis|membrane raft|response to cadmium ion|viral entry into host cell|perinuclear region of cytoplasm|negative regulation of cell death|extracellular exosome|cellular response to steroid hormone stimulus|cellular response to low-density lipoprotein particle stimulus|establishment of protein localization to membrane|integral component of lysosomal membrane "hsa04142,hsa04979" Lysosome|Cholesterol metabolism NPC2 3737.186627 3440.700733 4033.672521 1.172340414 0.229391548 0.471308835 1 140.6451607 171.9865401 10577 NPC intracellular cholesterol transporter 2 "GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005783,GO:0008203,GO:0009615,GO:0015485,GO:0015914,GO:0015918,GO:0019747,GO:0019899,GO:0030301,GO:0032366,GO:0032367,GO:0032934,GO:0033344,GO:0034383,GO:0035578,GO:0042632,GO:0043202,GO:0043312,GO:0046836,GO:0070062,GO:0120009,GO:0120020" protein binding|extracellular region|extracellular space|lysosome|endoplasmic reticulum|cholesterol metabolic process|response to virus|cholesterol binding|phospholipid transport|sterol transport|regulation of isoprenoid metabolic process|enzyme binding|cholesterol transport|intracellular sterol transport|intracellular cholesterol transport|sterol binding|cholesterol efflux|low-density lipoprotein particle clearance|azurophil granule lumen|cholesterol homeostasis|lysosomal lumen|neutrophil degranulation|glycolipid transport|extracellular exosome|intermembrane lipid transfer|cholesterol transfer activity "hsa04142,hsa04979" Lysosome|Cholesterol metabolism NPDC1 842.7596042 731.7832532 953.7359552 1.303303883 0.382173507 0.293455322 1 25.12694251 34.15869455 56654 "neural proliferation, differentiation and control 1" "GO:0005515,GO:0005886,GO:0016021,GO:0050776" protein binding|plasma membrane|integral component of membrane|regulation of immune response NPEPL1 1300.973376 1207.797602 1394.149149 1.154290377 0.207006198 0.540838773 1 26.26478648 31.62313188 79716 aminopeptidase like 1 "GO:0005634,GO:0005737,GO:0006508,GO:0030145,GO:0070006" nucleus|cytoplasm|proteolysis|manganese ion binding|metalloaminopeptidase activity NPEPPS 2547.373694 2726.171731 2368.575657 0.868828486 -0.20285669 0.524991103 1 29.77592858 26.98455716 9520 aminopeptidase puromycin sensitive "GO:0000209,GO:0004177,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008270,GO:0042277,GO:0043171,GO:0070006,GO:0070062,GO:0071456,GO:1903955" protein polyubiquitination|aminopeptidase activity|nucleus|cytoplasm|cytosol|proteolysis|zinc ion binding|peptide binding|peptide catabolic process|metalloaminopeptidase activity|extracellular exosome|cellular response to hypoxia|positive regulation of protein targeting to mitochondrion NPFF 6.493293363 6.08973581 6.896850916 1.132536966 0.17955814 1 1 0.460333784 0.543802457 8620 neuropeptide FF-amide peptide precursor "GO:0001664,GO:0002438,GO:0003254,GO:0005102,GO:0005184,GO:0005576,GO:0005615,GO:0007186,GO:0007204,GO:0007218,GO:0007268,GO:0010459,GO:0021510,GO:0030103,GO:0030425,GO:0031982,GO:0032099,GO:0042493,GO:0043204,GO:0043278,GO:0043679,GO:0045777,GO:0046676,GO:0051930,GO:0060079,GO:0060135,GO:0070253,GO:0098794" G protein-coupled receptor binding|acute inflammatory response to antigenic stimulus|regulation of membrane depolarization|signaling receptor binding|neuropeptide hormone activity|extracellular region|extracellular space|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|chemical synaptic transmission|negative regulation of heart rate|spinal cord development|vasopressin secretion|dendrite|vesicle|negative regulation of appetite|response to drug|perikaryon|response to morphine|axon terminus|positive regulation of blood pressure|negative regulation of insulin secretion|regulation of sensory perception of pain|excitatory postsynaptic potential|maternal process involved in female pregnancy|somatostatin secretion|postsynapse hsa04080 Neuroactive ligand-receptor interaction NPHP1 80.39752717 74.09178569 86.70326866 1.170214321 0.226772779 0.768140461 1 1.235590242 1.508189136 4867 nephrocystin 1 "GO:0005198,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005911,GO:0005912,GO:0005923,GO:0005929,GO:0007165,GO:0007588,GO:0007632,GO:0016020,GO:0030030,GO:0030036,GO:0031514,GO:0032391,GO:0048515,GO:0060041,GO:0090251,GO:0097711,GO:0098609,GO:1903348" structural molecule activity|protein binding|cytoplasm|cytosol|cytoskeleton|cell-cell junction|adherens junction|bicellular tight junction|cilium|signal transduction|excretion|visual behavior|membrane|cell projection organization|actin cytoskeleton organization|motile cilium|photoreceptor connecting cilium|spermatid differentiation|retina development in camera-type eye|protein localization involved in establishment of planar polarity|ciliary basal body-plasma membrane docking|cell-cell adhesion|positive regulation of bicellular tight junction assembly NPHP3 278.6568777 291.2923629 266.0213925 0.913245338 -0.130925611 0.792583414 1 2.758588363 2.627787809 27031 nephrocystin 3 "GO:0001822,GO:0001947,GO:0003283,GO:0005515,GO:0005576,GO:0005829,GO:0005929,GO:0007368,GO:0016055,GO:0030324,GO:0035469,GO:0045494,GO:0048496,GO:0060027,GO:0060271,GO:0060287,GO:0060993,GO:0071908,GO:0071909,GO:0071910,GO:0072189,GO:0090090,GO:2000095,GO:2000167" "kidney development|heart looping|atrial septum development|protein binding|extracellular region|cytosol|cilium|determination of left/right symmetry|Wnt signaling pathway|lung development|determination of pancreatic left/right asymmetry|photoreceptor cell maintenance|maintenance of animal organ identity|convergent extension involved in gastrulation|cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry|kidney morphogenesis|determination of intestine left/right asymmetry|determination of stomach left/right asymmetry|determination of liver left/right asymmetry|ureter development|negative regulation of canonical Wnt signaling pathway|regulation of Wnt signaling pathway, planar cell polarity pathway|regulation of planar cell polarity pathway involved in neural tube closure" NPHP4 396.6280647 374.5187523 418.737377 1.118067852 0.161007744 0.714797458 1 2.429621312 2.833496487 261734 nephrocystin 4 "GO:0005198,GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0005911,GO:0005923,GO:0007165,GO:0007632,GO:0016604,GO:0030036,GO:0030317,GO:0035329,GO:0035845,GO:0035869,GO:0036064,GO:0043231,GO:0045494,GO:0060041,GO:0090090,GO:0097470,GO:0097546,GO:0097711,GO:0097730,GO:0098609,GO:0120206,GO:1903348,GO:1904491" structural molecule activity|protein binding|nucleoplasm|centrosome|cytosol|cell-cell junction|bicellular tight junction|signal transduction|visual behavior|nuclear body|actin cytoskeleton organization|flagellated sperm motility|hippo signaling|photoreceptor cell outer segment organization|ciliary transition zone|ciliary basal body|intracellular membrane-bounded organelle|photoreceptor cell maintenance|retina development in camera-type eye|negative regulation of canonical Wnt signaling pathway|ribbon synapse|ciliary base|ciliary basal body-plasma membrane docking|non-motile cilium|cell-cell adhesion|photoreceptor distal connecting cilium|positive regulation of bicellular tight junction assembly|protein localization to ciliary transition zone NPIPA1 65.51464049 66.98709391 64.04218708 0.956037698 -0.064860588 0.954611338 1 3.129760139 3.121059171 9284 nuclear pore complex interacting protein family member A1 "GO:0005643,GO:0005654,GO:0015031,GO:0031965,GO:0051028" nuclear pore|nucleoplasm|protein transport|nuclear membrane|mRNA transport NPIPA2 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.039480752 0.029982525 642799 nuclear pore complex interacting protein family member A2 GO:0005654 nucleoplasm NPIPA5 23.31701732 11.16451565 35.469519 3.176986813 1.667659102 0.123595648 1 0.274087897 0.908283031 100288332 nuclear pore complex interacting protein family member A5 GO:0005654 nucleoplasm NPIPA7 19.46503431 17.25425146 21.67581716 1.256259491 0.329134496 0.806311826 1 0.395414917 0.518141449 101059938 nuclear pore complex interacting protein family member A7 "GO:0005515,GO:0005654" protein binding|nucleoplasm NPIPA8 63.36596235 54.80762229 71.92430241 1.312304738 0.392102775 0.628176859 1 1.240309526 1.697777234 101059953 nuclear pore complex interacting protein family member A8 GO:0005654 nucleoplasm NPIPB11 20.47999028 19.2841634 21.67581716 1.12402165 0.168669824 0.923679506 1 0.173692841 0.203644425 728888 nuclear pore complex interacting protein family member B11 "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane NPIPB12 14.1203089 22.3290313 5.911586499 0.264748901 -1.917303399 0.133452681 1 0.36945007 0.102024823 440353 nuclear pore complex interacting protein family member B12 "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane NPIPB13 7.493403555 7.104691779 7.882115332 1.109423966 0.149810797 1 1 0.092168948 0.106659147 613037 "nuclear pore complex interacting protein family, member B13" "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane NPIPB2 11.97163076 10.14955968 13.79370183 1.359044359 0.442592546 0.785314006 1 0.133969088 0.189912768 729978 nuclear pore complex interacting protein family member B2 GO:0005654 nucleoplasm NPIPB3 103.8926938 97.43577296 110.3496147 1.132536966 0.17955814 0.799918836 1 1.34535937 1.589302709 23117 nuclear pore complex interacting protein family member B3 "GO:0003674,GO:0005515,GO:0005654,GO:0008150,GO:0016021" molecular_function|protein binding|nucleoplasm|biological_process|integral component of membrane NPIPB4 29.92907689 25.37389921 34.48425458 1.359044359 0.442592546 0.673478543 1 0.224785461 0.31865283 440345 nuclear pore complex interacting protein family member B4 "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane NPIPB5 280.704357 262.8735958 298.5351182 1.135660344 0.183531415 0.708580504 1 3.099073619 3.671100583 100132247 nuclear pore complex interacting protein family member B5 "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane NPIPB9 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.022393352 0.034011978 100507607 nuclear pore complex interacting protein family member B9 GO:0005654 nucleoplasm NPL 8.045418867 11.16451565 4.926322083 0.441248168 -1.180337805 0.463589814 1 0.198959652 0.091572244 80896 N-acetylneuraminate pyruvate lyase "GO:0005515,GO:0005829,GO:0005975,GO:0008747,GO:0019262,GO:0042802" protein binding|cytosol|carbohydrate metabolic process|N-acetylneuraminate lyase activity|N-acetylneuraminate catabolic process|identical protein binding hsa00520 Amino sugar and nucleotide sugar metabolism NPLOC4 3223.70749 3160.572886 3286.842094 1.039951367 0.056516063 0.85977364 1 32.73453309 35.50872763 55666 "NPL4 homolog, ubiquitin recognition factor" "GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0006511,GO:0007030,GO:0030433,GO:0030970,GO:0031625,GO:0032480,GO:0034098,GO:0036501,GO:0039536,GO:0042175,GO:0043130,GO:0046872,GO:0070987" "protein binding|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|ubiquitin-dependent protein catabolic process|Golgi organization|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|ubiquitin protein ligase binding|negative regulation of type I interferon production|VCP-NPL4-UFD1 AAA ATPase complex|UFD1-NPL4 complex|negative regulation of RIG-I signaling pathway|nuclear outer membrane-endoplasmic reticulum membrane network|ubiquitin binding|metal ion binding|error-free translesion synthesis" hsa04141 Protein processing in endoplasmic reticulum NPM1 15970.43009 16589.4553 15351.40487 0.925371243 -0.111895829 0.751324598 1 387.5449202 374.0709457 4869 nucleophosmin 1 "GO:0000055,GO:0000056,GO:0001046,GO:0003682,GO:0003713,GO:0003723,GO:0004860,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005925,GO:0006281,GO:0006334,GO:0006338,GO:0006357,GO:0006407,GO:0006886,GO:0006913,GO:0007098,GO:0007165,GO:0007569,GO:0008104,GO:0008134,GO:0008284,GO:0008285,GO:0010824,GO:0010826,GO:0016020,GO:0016032,GO:0019901,GO:0030957,GO:0031616,GO:0032071,GO:0032991,GO:0032993,GO:0033613,GO:0034080,GO:0034644,GO:0042255,GO:0042273,GO:0042274,GO:0042393,GO:0042803,GO:0043023,GO:0043024,GO:0043066,GO:0044387,GO:0045727,GO:0045893,GO:0045944,GO:0046599,GO:0051059,GO:0051082,GO:0051092,GO:0060699,GO:0060735,GO:1902629,GO:1902751,GO:1990904" "ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|core promoter sequence-specific DNA binding|chromatin binding|transcription coactivator activity|RNA binding|protein kinase inhibitor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|focal adhesion|DNA repair|nucleosome assembly|chromatin remodeling|regulation of transcription by RNA polymerase II|rRNA export from nucleus|intracellular protein transport|nucleocytoplasmic transport|centrosome cycle|signal transduction|cell aging|protein localization|transcription factor binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of centrosome duplication|negative regulation of centrosome duplication|membrane|viral process|protein kinase binding|Tat protein binding|spindle pole centrosome|regulation of endodeoxyribonuclease activity|protein-containing complex|protein-DNA complex|activating transcription factor binding|CENP-A containing nucleosome assembly|cellular response to UV|ribosome assembly|ribosomal large subunit biogenesis|ribosomal small subunit biogenesis|histone binding|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|negative regulation of apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of translation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of centriole replication|NF-kappaB binding|unfolded protein binding|positive regulation of NF-kappaB transcription factor activity|regulation of endoribonuclease activity|regulation of eIF2 alpha phosphorylation by dsRNA|regulation of mRNA stability involved in cellular response to UV|positive regulation of cell cycle G2/M phase transition|ribonucleoprotein complex" NPM3 1442.185867 1499.089965 1385.28177 0.924081811 -0.113907513 0.733737453 1 86.57197066 83.44564102 10360 nucleophosmin/nucleoplasmin 3 "GO:0003682,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006338,GO:0006364,GO:0009303,GO:0015629,GO:0042393" chromatin binding|RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|chromatin remodeling|rRNA processing|rRNA transcription|actin cytoskeleton|histone binding NPNT 30.0478431 33.49354696 26.60213925 0.794246703 -0.332340898 0.760436199 1 0.359163666 0.297552598 255743 nephronectin "GO:0001657,GO:0001658,GO:0005178,GO:0005201,GO:0005509,GO:0005576,GO:0007160,GO:0010811,GO:0016020,GO:0030154,GO:0030198,GO:0033631,GO:0045669,GO:0062023,GO:0070062,GO:0070374,GO:0071356" ureteric bud development|branching involved in ureteric bud morphogenesis|integrin binding|extracellular matrix structural constituent|calcium ion binding|extracellular region|cell-matrix adhesion|positive regulation of cell-substrate adhesion|membrane|cell differentiation|extracellular matrix organization|cell-cell adhesion mediated by integrin|positive regulation of osteoblast differentiation|collagen-containing extracellular matrix|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to tumor necrosis factor hsa04512 ECM-receptor interaction NPR1 84.56399308 55.82257826 113.3054079 2.029741575 1.021296056 0.155641006 1 0.662421898 1.402462822 4881 natriuretic peptide receptor 1 "GO:0001653,GO:0004383,GO:0004672,GO:0005524,GO:0005525,GO:0005886,GO:0006182,GO:0006468,GO:0007165,GO:0007166,GO:0007168,GO:0007186,GO:0007589,GO:0008217,GO:0008528,GO:0010753,GO:0016021,GO:0016525,GO:0016941,GO:0017046,GO:0019901,GO:0019934,GO:0030308,GO:0035810,GO:0035815,GO:0042417,GO:0042562,GO:0043114,GO:0043235,GO:0048662,GO:0097746,GO:1903779" peptide receptor activity|guanylate cyclase activity|protein kinase activity|ATP binding|GTP binding|plasma membrane|cGMP biosynthetic process|protein phosphorylation|signal transduction|cell surface receptor signaling pathway|receptor guanylyl cyclase signaling pathway|G protein-coupled receptor signaling pathway|body fluid secretion|regulation of blood pressure|G protein-coupled peptide receptor activity|positive regulation of cGMP-mediated signaling|integral component of membrane|negative regulation of angiogenesis|natriuretic peptide receptor activity|peptide hormone binding|protein kinase binding|cGMP-mediated signaling|negative regulation of cell growth|positive regulation of urine volume|positive regulation of renal sodium excretion|dopamine metabolic process|hormone binding|regulation of vascular permeability|receptor complex|negative regulation of smooth muscle cell proliferation|blood vessel diameter maintenance|regulation of cardiac conduction "hsa00230,hsa04022,hsa04024,hsa04270,hsa04714,hsa04921,hsa04923,hsa04924,hsa04925" Purine metabolism|cGMP-PKG signaling pathway|cAMP signaling pathway|Vascular smooth muscle contraction|Thermogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion NPR2 26.56972609 31.46363502 21.67581716 0.688916495 -0.537598973 0.61649961 1 0.27013428 0.194116393 4882 natriuretic peptide receptor 2 "GO:0001503,GO:0001653,GO:0004383,GO:0004672,GO:0005515,GO:0005524,GO:0005525,GO:0005886,GO:0005887,GO:0006182,GO:0006468,GO:0007165,GO:0007168,GO:0008217,GO:0010753,GO:0016941,GO:0017046,GO:0019934,GO:0022414,GO:0042562,GO:0042802,GO:0051447,GO:0060348,GO:0097011,GO:1900194,GO:1903779" ossification|peptide receptor activity|guanylate cyclase activity|protein kinase activity|protein binding|ATP binding|GTP binding|plasma membrane|integral component of plasma membrane|cGMP biosynthetic process|protein phosphorylation|signal transduction|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|positive regulation of cGMP-mediated signaling|natriuretic peptide receptor activity|peptide hormone binding|cGMP-mediated signaling|reproductive process|hormone binding|identical protein binding|negative regulation of meiotic cell cycle|bone development|cellular response to granulocyte macrophage colony-stimulating factor stimulus|negative regulation of oocyte maturation|regulation of cardiac conduction "hsa00230,hsa04022,hsa04270,hsa04921" Purine metabolism|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Oxytocin signaling pathway NPR3 7.567632435 12.17947162 2.95579325 0.242686493 -2.042834281 0.21196309 1 0.179368209 0.045405348 4883 natriuretic peptide receptor 3 "GO:0001501,GO:0002158,GO:0005515,GO:0005887,GO:0007193,GO:0007194,GO:0007200,GO:0008217,GO:0008528,GO:0016941,GO:0017046,GO:0030157,GO:0031404,GO:0032991,GO:0033688,GO:0035810,GO:0042277,GO:0042562,GO:0042803,GO:0048015,GO:0048662,GO:0051000,GO:0070062,GO:0120163" skeletal system development|osteoclast proliferation|protein binding|integral component of plasma membrane|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|phospholipase C-activating G protein-coupled receptor signaling pathway|regulation of blood pressure|G protein-coupled peptide receptor activity|natriuretic peptide receptor activity|peptide hormone binding|pancreatic juice secretion|chloride ion binding|protein-containing complex|regulation of osteoblast proliferation|positive regulation of urine volume|peptide binding|hormone binding|protein homodimerization activity|phosphatidylinositol-mediated signaling|negative regulation of smooth muscle cell proliferation|positive regulation of nitric-oxide synthase activity|extracellular exosome|negative regulation of cold-induced thermogenesis NPRL2 407.1487688 420.1917709 394.1057666 0.937918812 -0.092465049 0.835194075 1 11.79669116 11.54094539 10641 "NPR2 like, GATOR1 complex subunit" "GO:0004672,GO:0005096,GO:0005515,GO:0005765,GO:0006468,GO:0006995,GO:0010508,GO:0032007,GO:0033673,GO:0034198,GO:0043547,GO:1990130,GO:2000785" protein kinase activity|GTPase activator activity|protein binding|lysosomal membrane|protein phosphorylation|cellular response to nitrogen starvation|positive regulation of autophagy|negative regulation of TOR signaling|negative regulation of kinase activity|cellular response to amino acid starvation|positive regulation of GTPase activity|GATOR1 complex|regulation of autophagosome assembly hsa04150 mTOR signaling pathway NPRL3 728.8967378 794.7105232 663.0829523 0.834370419 -0.261240084 0.486254907 1 11.26799676 9.806669562 8131 "NPR3 like, GATOR1 complex subunit" "GO:0003281,GO:0005096,GO:0005515,GO:0005765,GO:0032007,GO:0034198,GO:0035909,GO:0038202,GO:0043547,GO:0048738,GO:0060021,GO:1990130,GO:2000785" ventricular septum development|GTPase activator activity|protein binding|lysosomal membrane|negative regulation of TOR signaling|cellular response to amino acid starvation|aorta morphogenesis|TORC1 signaling|positive regulation of GTPase activity|cardiac muscle tissue development|roof of mouth development|GATOR1 complex|regulation of autophagosome assembly hsa04150 mTOR signaling pathway NPTN 2944.502064 3741.127699 2147.876428 0.574125398 -0.800562217 0.012291135 0.4872522 68.50141723 41.02251153 27020 neuroplastin "GO:0001772,GO:0001818,GO:0001934,GO:0005105,GO:0005515,GO:0005886,GO:0006874,GO:0007156,GO:0007204,GO:0007411,GO:0008542,GO:0009986,GO:0010976,GO:0030424,GO:0030425,GO:0042734,GO:0044325,GO:0045743,GO:0048170,GO:0050839,GO:0060077,GO:0060291,GO:0070374,GO:0070593,GO:0098632,GO:0098685,GO:0098978,GO:0098982,GO:0099059,GO:0099061,GO:0099557,GO:1900273,GO:1902683,GO:1903829,GO:1904861" "immunological synapse|negative regulation of cytokine production|positive regulation of protein phosphorylation|type 1 fibroblast growth factor receptor binding|protein binding|plasma membrane|cellular calcium ion homeostasis|homophilic cell adhesion via plasma membrane adhesion molecules|positive regulation of cytosolic calcium ion concentration|axon guidance|visual learning|cell surface|positive regulation of neuron projection development|axon|dendrite|presynaptic membrane|ion channel binding|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|cell adhesion molecule binding|inhibitory synapse|long-term synaptic potentiation|positive regulation of ERK1 and ERK2 cascade|dendrite self-avoidance|cell-cell adhesion mediator activity|Schaffer collateral - CA1 synapse|glutamatergic synapse|GABA-ergic synapse|integral component of presynaptic active zone membrane|integral component of postsynaptic density membrane|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission|positive regulation of long-term synaptic potentiation|regulation of receptor localization to synapse|positive regulation of cellular protein localization|excitatory synapse assembly" NPTXR 169.0483141 173.5574706 164.5391576 0.948038462 -0.076982504 0.902657538 1 1.507731323 1.490959492 23467 neuronal pentraxin receptor "GO:0016021,GO:0046872,GO:0098962,GO:0098978" integral component of membrane|metal ion binding|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse NPW 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.205341968 0 283869 neuropeptide W "GO:0001664,GO:0005515,GO:0005576,GO:0007186,GO:0007218,GO:0007631" G protein-coupled receptor binding|protein binding|extracellular region|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|feeding behavior hsa04080 Neuroactive ligand-receptor interaction NPY1R 122.4142794 151.2284393 93.60011957 0.618931995 -0.692147193 0.275687544 1 2.038644383 1.316134696 4886 neuropeptide Y receptor Y1 "GO:0001601,GO:0001602,GO:0003151,GO:0004983,GO:0005515,GO:0005886,GO:0005887,GO:0006006,GO:0007186,GO:0007187,GO:0007193,GO:0007218,GO:0007626,GO:0007631,GO:0008217,GO:0019233,GO:0040014" "peptide YY receptor activity|pancreatic polypeptide receptor activity|outflow tract morphogenesis|neuropeptide Y receptor activity|protein binding|plasma membrane|integral component of plasma membrane|glucose metabolic process|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|locomotory behavior|feeding behavior|regulation of blood pressure|sensory perception of pain|regulation of multicellular organism growth" "hsa04024,hsa04080,hsa04923" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Regulation of lipolysis in adipocytes NPY5R 12.47910874 11.16451565 13.79370183 1.235494872 0.305089022 0.870917903 1 0.052697421 0.067911956 4889 neuropeptide Y receptor Y5 "GO:0001601,GO:0001602,GO:0002675,GO:0002865,GO:0003151,GO:0003214,GO:0004983,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007218,GO:0007268,GO:0007568,GO:0014050,GO:0016020,GO:0032229,GO:0042755,GO:0043005,GO:0043066,GO:0045202,GO:0048661,GO:0060112,GO:0070374" "peptide YY receptor activity|pancreatic polypeptide receptor activity|positive regulation of acute inflammatory response|negative regulation of acute inflammatory response to antigenic stimulus|outflow tract morphogenesis|cardiac left ventricle morphogenesis|neuropeptide Y receptor activity|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|aging|negative regulation of glutamate secretion|membrane|negative regulation of synaptic transmission, GABAergic|eating behavior|neuron projection|negative regulation of apoptotic process|synapse|positive regulation of smooth muscle cell proliferation|generation of ovulation cycle rhythm|positive regulation of ERK1 and ERK2 cascade" hsa04080 Neuroactive ligand-receptor interaction NQO1 4601.819495 3579.7497 5623.88929 1.571028636 0.651709478 0.042340664 0.940614529 71.91657823 117.8498534 1728 NAD(P)H quinone dehydrogenase 1 "GO:0002931,GO:0003723,GO:0003955,GO:0004128,GO:0004784,GO:0005515,GO:0005737,GO:0005829,GO:0006116,GO:0006521,GO:0006805,GO:0006809,GO:0006979,GO:0007271,GO:0007568,GO:0007584,GO:0009636,GO:0009725,GO:0009743,GO:0014075,GO:0019430,GO:0030425,GO:0032355,GO:0033574,GO:0042493,GO:0042802,GO:0043025,GO:0043066,GO:0043086,GO:0043279,GO:0043525,GO:0045202,GO:0045454,GO:0045471,GO:0051602,GO:0070301,GO:0070995,GO:0071248,GO:1904772,GO:1904844,GO:1904880,GO:1905395" "response to ischemia|RNA binding|NAD(P)H dehydrogenase (quinone) activity|cytochrome-b5 reductase activity, acting on NAD(P)H|superoxide dismutase activity|protein binding|cytoplasm|cytosol|NADH oxidation|regulation of cellular amino acid metabolic process|xenobiotic metabolic process|nitric oxide biosynthetic process|response to oxidative stress|synaptic transmission, cholinergic|aging|response to nutrient|response to toxic substance|response to hormone|response to carbohydrate|response to amine|removal of superoxide radicals|dendrite|response to estradiol|response to testosterone|response to drug|identical protein binding|neuronal cell body|negative regulation of apoptotic process|negative regulation of catalytic activity|response to alkaloid|positive regulation of neuron apoptotic process|synapse|cell redox homeostasis|response to ethanol|response to electrical stimulus|cellular response to hydrogen peroxide|NADPH oxidation|cellular response to metal ion|response to tetrachloromethane|response to L-glutamine|response to hydrogen sulfide|response to flavonoid" "hsa00130,hsa05200,hsa05225,hsa05418" Ubiquinone and other terpenoid-quinone biosynthesis|Pathways in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis NQO2 484.2287609 536.9117073 431.5458144 0.803755643 -0.315171134 0.445202449 1 17.12385634 14.35626745 4835 N-ribosyldihydronicotinamide:quinone reductase 2 "GO:0001512,GO:0003955,GO:0005515,GO:0005654,GO:0005829,GO:0006805,GO:0007613,GO:0008270,GO:0009055,GO:0016491,GO:0016661,GO:0022900,GO:0031404,GO:0042803,GO:0043525,GO:0055114,GO:0070062,GO:0070374,GO:0071949,GO:1904408,GO:1904707,GO:1905594,GO:2000379" "dihydronicotinamide riboside quinone reductase activity|NAD(P)H dehydrogenase (quinone) activity|protein binding|nucleoplasm|cytosol|xenobiotic metabolic process|memory|zinc ion binding|electron transfer activity|oxidoreductase activity|oxidoreductase activity, acting on other nitrogenous compounds as donors|electron transport chain|chloride ion binding|protein homodimerization activity|positive regulation of neuron apoptotic process|oxidation-reduction process|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|FAD binding|melatonin binding|positive regulation of vascular associated smooth muscle cell proliferation|resveratrol binding|positive regulation of reactive oxygen species metabolic process" NR1D1 264.9374047 296.3671428 233.5076667 0.787899983 -0.343915591 0.486538354 1 5.707205422 4.690406958 9572 nuclear receptor subfamily 1 group D member 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001222,GO:0001227,GO:0001678,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005978,GO:0006367,GO:0007623,GO:0008270,GO:0009755,GO:0010498,GO:0016604,GO:0019216,GO:0020037,GO:0030154,GO:0030425,GO:0030522,GO:0031648,GO:0032922,GO:0034144,GO:0042632,GO:0042749,GO:0042752,GO:0043124,GO:0043197,GO:0043401,GO:0044321,GO:0045598,GO:0045892,GO:0045893,GO:0045944,GO:0050728,GO:0060086,GO:0061178,GO:0061469,GO:0061889,GO:0070859,GO:0070888,GO:0071222,GO:0071347,GO:0071356,GO:0120163,GO:0150079,GO:1903979,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription corepressor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|cellular glucose homeostasis|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|glycogen biosynthetic process|transcription initiation from RNA polymerase II promoter|circadian rhythm|zinc ion binding|hormone-mediated signaling pathway|proteasomal protein catabolic process|nuclear body|regulation of lipid metabolic process|heme binding|cell differentiation|dendrite|intracellular receptor signaling pathway|protein destabilization|circadian regulation of gene expression|negative regulation of toll-like receptor 4 signaling pathway|cholesterol homeostasis|regulation of circadian sleep/wake cycle|regulation of circadian rhythm|negative regulation of I-kappaB kinase/NF-kappaB signaling|dendritic spine|steroid hormone mediated signaling pathway|response to leptin|regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|circadian temperature homeostasis|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of type B pancreatic cell proliferation|negative regulation of astrocyte activation|positive regulation of bile acid biosynthetic process|E-box binding|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|negative regulation of cold-induced thermogenesis|negative regulation of neuroinflammatory response|negative regulation of microglial cell activation|sequence-specific double-stranded DNA binding" hsa04710 Circadian rhythm NR1D2 1407.967599 1348.876482 1467.058716 1.087615312 0.121168368 0.718232819 1 12.73598719 14.4485364 9975 nuclear receptor subfamily 1 group D member 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006367,GO:0008270,GO:0009755,GO:0019216,GO:0030154,GO:0030522,GO:0042752,GO:0045892,GO:0045893,GO:0045944,GO:0048512,GO:0050727,GO:0050728,GO:0055088,GO:0097009,GO:1990837,GO:2001014" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|zinc ion binding|hormone-mediated signaling pathway|regulation of lipid metabolic process|cell differentiation|intracellular receptor signaling pathway|regulation of circadian rhythm|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|circadian behavior|regulation of inflammatory response|negative regulation of inflammatory response|lipid homeostasis|energy homeostasis|sequence-specific double-stranded DNA binding|regulation of skeletal muscle cell differentiation" NR1H2 999.7296455 921.5800193 1077.879272 1.16959922 0.226014254 0.522076878 1 19.31903015 23.56884607 7376 nuclear receptor subfamily 1 group H member 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006367,GO:0008270,GO:0010745,GO:0010867,GO:0010875,GO:0010884,GO:0010887,GO:0030154,GO:0031667,GO:0032270,GO:0032369,GO:0032376,GO:0034191,GO:0036151,GO:0042632,GO:0045723,GO:0045861,GO:0045892,GO:0045893,GO:0045944,GO:0046965,GO:0048384,GO:0048550,GO:0051006,GO:0051117,GO:0060336,GO:0090108,GO:0090187,GO:0090340,GO:0120163,GO:1903573" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|transcription initiation from RNA polymerase II promoter|zinc ion binding|negative regulation of macrophage derived foam cell differentiation|positive regulation of triglyceride biosynthetic process|positive regulation of cholesterol efflux|positive regulation of lipid storage|negative regulation of cholesterol storage|cell differentiation|response to nutrient levels|positive regulation of cellular protein metabolic process|negative regulation of lipid transport|positive regulation of cholesterol transport|apolipoprotein A-I receptor binding|phosphatidylcholine acyl-chain remodeling|cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|retinoic acid receptor signaling pathway|negative regulation of pinocytosis|positive regulation of lipoprotein lipase activity|ATPase binding|negative regulation of interferon-gamma-mediated signaling pathway|positive regulation of high-density lipoprotein particle assembly|positive regulation of pancreatic juice secretion|positive regulation of secretion of lysosomal enzymes|negative regulation of cold-induced thermogenesis|negative regulation of response to endoplasmic reticulum stress" hsa04931 Insulin resistance Ecdysone_rcpt NR1H3 89.05434446 93.37594909 84.73273982 0.907436451 -0.140131483 0.856562958 1 1.765271523 1.670873863 10062 nuclear receptor subfamily 1 group H member 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006367,GO:0008270,GO:0010745,GO:0010867,GO:0010875,GO:0010887,GO:0015485,GO:0030154,GO:0030522,GO:0032270,GO:0032369,GO:0032376,GO:0032570,GO:0032810,GO:0034145,GO:0036151,GO:0042632,GO:0042752,GO:0043031,GO:0043235,GO:0043277,GO:0045723,GO:0045893,GO:0045944,GO:0048550,GO:0050728,GO:0051006,GO:0055088,GO:0055092,GO:0060336,GO:0070328,GO:0071222,GO:0090188,GO:0090341,GO:0090575,GO:0120163,GO:1903573" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription initiation from RNA polymerase II promoter|zinc ion binding|negative regulation of macrophage derived foam cell differentiation|positive regulation of triglyceride biosynthetic process|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|cholesterol binding|cell differentiation|intracellular receptor signaling pathway|positive regulation of cellular protein metabolic process|negative regulation of lipid transport|positive regulation of cholesterol transport|response to progesterone|sterol response element binding|positive regulation of toll-like receptor 4 signaling pathway|phosphatidylcholine acyl-chain remodeling|cholesterol homeostasis|regulation of circadian rhythm|negative regulation of macrophage activation|receptor complex|apoptotic cell clearance|positive regulation of fatty acid biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of pinocytosis|negative regulation of inflammatory response|positive regulation of lipoprotein lipase activity|lipid homeostasis|sterol homeostasis|negative regulation of interferon-gamma-mediated signaling pathway|triglyceride homeostasis|cellular response to lipopolysaccharide|negative regulation of pancreatic juice secretion|negative regulation of secretion of lysosomal enzymes|RNA polymerase II transcription regulator complex|negative regulation of cold-induced thermogenesis|negative regulation of response to endoplasmic reticulum stress" "hsa03320,hsa04931,hsa04932,hsa05160" PPAR signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hepatitis C Ecdysone_rcpt NR2C1 695.3937883 659.7213794 731.0661971 1.108143862 0.148145187 0.697545028 1 7.325709386 8.467627816 7181 nuclear receptor subfamily 2 group C member 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003707,GO:0004879,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0008270,GO:0016605,GO:0030154,GO:0030522,GO:0038023,GO:0042803,GO:0042826,GO:0043401,GO:0048386,GO:0048856,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|zinc ion binding|PML body|cell differentiation|intracellular receptor signaling pathway|signaling receptor activity|protein homodimerization activity|histone deacetylase binding|steroid hormone mediated signaling pathway|positive regulation of retinoic acid receptor signaling pathway|anatomical structure development|sequence-specific double-stranded DNA binding" NR2C2 2241.345419 2348.608111 2134.082726 0.908658501 -0.138189903 0.666640196 1 11.33168671 10.74017068 7182 nuclear receptor subfamily 2 group C member 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0004879,GO:0005515,GO:0005654,GO:0006355,GO:0006357,GO:0006367,GO:0007283,GO:0007399,GO:0008270,GO:0030154,GO:0030522,GO:0040019,GO:0043565,GO:0045944,GO:0048856,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|spermatogenesis|nervous system development|zinc ion binding|cell differentiation|intracellular receptor signaling pathway|positive regulation of embryonic development|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|anatomical structure development|sequence-specific double-stranded DNA binding" Retinoic_acid_rcpt NR2C2AP 231.8055996 186.7518982 276.859301 1.482497922 0.568030083 0.269485835 1 7.332034746 11.33795 126382 nuclear receptor 2C2 associated protein "GO:0005515,GO:0005654,GO:0006367" protein binding|nucleoplasm|transcription initiation from RNA polymerase II promoter NR2E3 67.02222867 69.01700585 65.02745149 0.942194618 -0.085903003 0.931384003 1 1.246600524 1.225134738 10002 nuclear receptor subfamily 2 group E member 3 "GO:0000122,GO:0000978,GO:0001228,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007165,GO:0007601,GO:0007602,GO:0008270,GO:0008285,GO:0030154,GO:0030522,GO:0042462,GO:0043401,GO:0043565,GO:0045944,GO:0048856,GO:0060041" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|visual perception|phototransduction|zinc ion binding|negative regulation of cell population proliferation|cell differentiation|intracellular receptor signaling pathway|eye photoreceptor cell development|steroid hormone mediated signaling pathway|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|anatomical structure development|retina development in camera-type eye" NR2F1 248.7723381 268.9633316 228.5813446 0.849860623 -0.234701836 0.644280915 1 3.41575825 3.027964388 7025 nuclear receptor subfamily 2 group F member 1 "GO:0000122,GO:0000978,GO:0001227,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006367,GO:0007165,GO:0007399,GO:0008270,GO:0010977,GO:0030154,GO:0030522,GO:0043565,GO:0044323,GO:0045944,GO:0048856,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|nervous system development|zinc ion binding|negative regulation of neuron projection development|cell differentiation|intracellular receptor signaling pathway|sequence-specific DNA binding|retinoic acid-responsive element binding|positive regulation of transcription by RNA polymerase II|anatomical structure development|sequence-specific double-stranded DNA binding" COUP_TF NR2F2 1359.736902 1318.427803 1401.046 1.06266418 0.087685753 0.795657884 1 11.62495075 12.88555393 7026 nuclear receptor subfamily 2 group F member 2 "GO:0000122,GO:0000978,GO:0001764,GO:0001893,GO:0001937,GO:0001972,GO:0003084,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007519,GO:0008270,GO:0009566,GO:0009952,GO:0009956,GO:0010596,GO:0030154,GO:0030522,GO:0030900,GO:0032355,GO:0042803,GO:0043565,GO:0045736,GO:0045892,GO:0045893,GO:0045944,GO:0048514,GO:0048856,GO:0060173,GO:0060674,GO:0060707,GO:0060838" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|neuron migration|maternal placenta development|negative regulation of endothelial cell proliferation|retinoic acid binding|positive regulation of systemic arterial blood pressure|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|skeletal muscle tissue development|zinc ion binding|fertilization|anterior/posterior pattern specification|radial pattern formation|negative regulation of endothelial cell migration|cell differentiation|intracellular receptor signaling pathway|forebrain development|response to estradiol|protein homodimerization activity|sequence-specific DNA binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|blood vessel morphogenesis|anatomical structure development|limb development|placenta blood vessel development|trophoblast giant cell differentiation|lymphatic endothelial cell fate commitment" COUP_TF NR2F6 1076.68815 1063.673855 1089.702445 1.024470461 0.034878387 0.9228569 1 22.6065163 24.15733448 2063 nuclear receptor subfamily 2 group F member 6 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0008270,GO:0030154,GO:0030522,GO:0043153,GO:0043565,GO:0048666,GO:0048856,GO:0050965,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|zinc ion binding|cell differentiation|intracellular receptor signaling pathway|entrainment of circadian clock by photoperiod|sequence-specific DNA binding|neuron development|anatomical structure development|detection of temperature stimulus involved in sensory perception of pain|sequence-specific double-stranded DNA binding" NR3C1 1792.116309 2082.689647 1501.542971 0.720963382 -0.472002109 0.146896028 1 5.275363008 3.967176169 2908 nuclear receptor subfamily 3 group C member 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001046,GO:0001227,GO:0001228,GO:0003700,GO:0003723,GO:0004879,GO:0004883,GO:0005496,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005815,GO:0005819,GO:0005829,GO:0006325,GO:0006355,GO:0006357,GO:0006367,GO:0006915,GO:0007049,GO:0007059,GO:0007165,GO:0008270,GO:0016607,GO:0019901,GO:0030518,GO:0032991,GO:0042921,GO:0043402,GO:0045892,GO:0045944,GO:0051301,GO:0051879,GO:0071383,GO:0071385,GO:0071549,GO:0071560,GO:1902895,GO:1990239,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|core promoter sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|RNA binding|nuclear receptor activity|glucocorticoid receptor activity|steroid binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|microtubule organizing center|spindle|cytosol|chromatin organization|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|apoptotic process|cell cycle|chromosome segregation|signal transduction|zinc ion binding|nuclear speck|protein kinase binding|intracellular steroid hormone receptor signaling pathway|protein-containing complex|glucocorticoid receptor signaling pathway|glucocorticoid mediated signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell division|Hsp90 protein binding|cellular response to steroid hormone stimulus|cellular response to glucocorticoid stimulus|cellular response to dexamethasone stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of pri-miRNA transcription by RNA polymerase II|steroid hormone binding|sequence-specific double-stranded DNA binding" hsa04080 Neuroactive ligand-receptor interaction GCR NR3C2 334.6036654 344.0700733 325.1372575 0.944973954 -0.08165353 0.86418751 1 2.132656395 2.102115901 4306 nuclear receptor subfamily 3 group C member 2 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0003707,GO:0004879,GO:0005496,GO:0005515,GO:0005654,GO:0005789,GO:0005829,GO:0006357,GO:0006367,GO:0007165,GO:0008270,GO:0030518,GO:0043235,GO:1901224,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|steroid binding|protein binding|nucleoplasm|endoplasmic reticulum membrane|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|zinc ion binding|intracellular steroid hormone receptor signaling pathway|receptor complex|positive regulation of NIK/NF-kappaB signaling|sequence-specific double-stranded DNA binding" hsa04960 Aldosterone-regulated sodium reabsorption ThyrH_rcpt NR4A1 302.961881 268.9633316 336.9604305 1.252811781 0.325169684 0.492287673 1 1.694916499 2.214879307 3164 nuclear receptor subfamily 4 group A member 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001938,GO:0002042,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005739,GO:0005829,GO:0006357,GO:0006367,GO:0007165,GO:0008270,GO:0030522,GO:0031965,GO:0035259,GO:0035767,GO:0035924,GO:0044344,GO:0045444,GO:0045786,GO:0045944,GO:0046982,GO:0061469,GO:0071376,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|DNA binding|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|zinc ion binding|intracellular receptor signaling pathway|nuclear membrane|glucocorticoid receptor binding|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|cellular response to fibroblast growth factor stimulus|fat cell differentiation|negative regulation of cell cycle|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|regulation of type B pancreatic cell proliferation|cellular response to corticotropin-releasing hormone stimulus|sequence-specific double-stranded DNA binding" "hsa04010,hsa04151,hsa04925,hsa04927,hsa04934" MAPK signaling pathway|PI3K-Akt signaling pathway|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome Nuc_orph_r... NR4A2 47.4681197 45.67301858 49.26322083 1.078606634 0.109168812 0.924091403 1 0.665279628 0.748485242 4929 nuclear receptor subfamily 4 group A member 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0001764,GO:0001975,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006351,GO:0006357,GO:0006367,GO:0007165,GO:0008013,GO:0008270,GO:0008344,GO:0009791,GO:0016607,GO:0021952,GO:0021953,GO:0021986,GO:0030522,GO:0031668,GO:0032991,GO:0034599,GO:0035259,GO:0042053,GO:0042416,GO:0042551,GO:0043085,GO:0043524,GO:0043576,GO:0045444,GO:0045944,GO:0046965,GO:0046982,GO:0051866,GO:0060070,GO:0071376,GO:0071542,GO:1904948,GO:1990837,GO:2001234" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|neuron migration|response to amphetamine|DNA binding|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|beta-catenin binding|zinc ion binding|adult locomotory behavior|post-embryonic development|nuclear speck|central nervous system projection neuron axonogenesis|central nervous system neuron differentiation|habenula development|intracellular receptor signaling pathway|cellular response to extracellular stimulus|protein-containing complex|cellular response to oxidative stress|glucocorticoid receptor binding|regulation of dopamine metabolic process|dopamine biosynthetic process|neuron maturation|positive regulation of catalytic activity|negative regulation of neuron apoptotic process|regulation of respiratory gaseous exchange|fat cell differentiation|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|protein heterodimerization activity|general adaptation syndrome|canonical Wnt signaling pathway|cellular response to corticotropin-releasing hormone stimulus|dopaminergic neuron differentiation|midbrain dopaminergic neuron differentiation|sequence-specific double-stranded DNA binding|negative regulation of apoptotic signaling pathway" "hsa04925,hsa04928" "Aldosterone synthesis and secretion|Parathyroid hormone synthesis, secretion and action" NR4A3 41.24205031 57.8524902 24.63161041 0.425765777 -1.231868106 0.173284972 1 0.462367767 0.205340318 8013 nuclear receptor subfamily 4 group A member 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007369,GO:0008270,GO:0009444,GO:0010613,GO:0010828,GO:0019901,GO:0030522,GO:0031100,GO:0032765,GO:0035259,GO:0035497,GO:0035726,GO:0038097,GO:0042803,GO:0043303,GO:0043401,GO:0044320,GO:0045333,GO:0045444,GO:0045652,GO:0045944,GO:0046321,GO:0048008,GO:0048660,GO:0048661,GO:0050679,GO:0061469,GO:0071376,GO:0071870,GO:0097009,GO:1900625,GO:1903208,GO:1904707,GO:1904754,GO:2000253" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|gastrulation|zinc ion binding|pyruvate oxidation|positive regulation of cardiac muscle hypertrophy|positive regulation of glucose transmembrane transport|protein kinase binding|intracellular receptor signaling pathway|animal organ regeneration|positive regulation of mast cell cytokine production|glucocorticoid receptor binding|cAMP response element binding|common myeloid progenitor cell proliferation|positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway|protein homodimerization activity|mast cell degranulation|steroid hormone mediated signaling pathway|cellular response to leptin stimulus|cellular respiration|fat cell differentiation|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of fatty acid oxidation|platelet-derived growth factor receptor signaling pathway|regulation of smooth muscle cell proliferation|positive regulation of smooth muscle cell proliferation|positive regulation of epithelial cell proliferation|regulation of type B pancreatic cell proliferation|cellular response to corticotropin-releasing hormone stimulus|cellular response to catecholamine stimulus|energy homeostasis|positive regulation of monocyte aggregation|negative regulation of hydrogen peroxide-induced neuron death|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration|positive regulation of feeding behavior" hsa05202 Transcriptional misregulation in cancer NR5A2 11.40476967 5.074779842 17.7347595 3.494685494 1.805162625 0.190072376 1 0.031493652 0.114801366 2494 nuclear receptor subfamily 5 group A member 2 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003682,GO:0003700,GO:0004879,GO:0005515,GO:0005543,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0006367,GO:0008206,GO:0008270,GO:0009755,GO:0009792,GO:0009888,GO:0030522,GO:0030855,GO:0042127,GO:0042592,GO:0042632,GO:0043565,GO:0045070,GO:0045893,GO:0045944,GO:0061113,GO:0090575,GO:0097720,GO:1990830,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|phospholipid binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|bile acid metabolic process|zinc ion binding|hormone-mediated signaling pathway|embryo development ending in birth or egg hatching|tissue development|intracellular receptor signaling pathway|epithelial cell differentiation|regulation of cell population proliferation|homeostatic process|cholesterol homeostasis|sequence-specific DNA binding|positive regulation of viral genome replication|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|pancreas morphogenesis|RNA polymerase II transcription regulator complex|calcineurin-mediated signaling|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" hsa04950 Maturity onset diabetes of the young Retinoic_acid_rcpt NR6A1 216.8309167 207.0510175 226.6108158 1.094468496 0.130230428 0.811282921 1 1.148817222 1.311505549 2649 nuclear receptor subfamily 6 group A member 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0004879,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007276,GO:0008270,GO:0030522,GO:0042803,GO:0043565,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nuclear receptor activity|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|gamete generation|zinc ion binding|intracellular receptor signaling pathway|protein homodimerization activity|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" NRARP 12.58302917 18.26920743 6.896850916 0.377512322 -1.405404361 0.286128802 1 0.350348696 0.137958215 441478 NOTCH regulated ankyrin repeat protein "GO:0000122,GO:0001569,GO:0001938,GO:0002043,GO:0005515,GO:0007219,GO:0032525,GO:0045581,GO:0045746,GO:0090263,GO:1902367" negative regulation of transcription by RNA polymerase II|branching involved in blood vessel morphogenesis|positive regulation of endothelial cell proliferation|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|protein binding|Notch signaling pathway|somite rostral/caudal axis specification|negative regulation of T cell differentiation|negative regulation of Notch signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of Notch signaling pathway involved in somitogenesis NRAS 2886.851226 2797.218649 2976.483802 1.064086929 0.089616015 0.778985847 1 32.74832561 36.34813547 4893 "NRAS proto-oncogene, GTPase" "GO:0000139,GO:0000165,GO:0001938,GO:0002223,GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0005886,GO:0007265,GO:0016020,GO:0019003,GO:0043312,GO:0044877,GO:0070062,GO:0070821" Golgi membrane|MAPK cascade|positive regulation of endothelial cell proliferation|stimulatory C-type lectin receptor signaling pathway|GTPase activity|protein binding|GTP binding|Golgi apparatus|plasma membrane|Ras protein signal transduction|membrane|GDP binding|neutrophil degranulation|protein-containing complex binding|extracellular exosome|tertiary granule membrane "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04062,hsa04068,hsa04071,hsa04072,hsa04137,hsa04140,hsa04150,hsa04151,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04371,hsa04540,hsa04550,hsa04625,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04929,hsa04933,hsa04935,hsa05010,hsa05022,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" NRBF2 708.1995041 693.2149264 723.1840817 1.043232126 0.061060203 0.874712174 1 17.21868097 18.73685785 29982 nuclear receptor binding factor 2 "GO:0005515,GO:0005654,GO:0005737,GO:0005776,GO:0006367,GO:0006914,GO:0031410,GO:0034976,GO:0035032,GO:0043550" "protein binding|nucleoplasm|cytoplasm|autophagosome|transcription initiation from RNA polymerase II promoter|autophagy|cytoplasmic vesicle|response to endoplasmic reticulum stress|phosphatidylinositol 3-kinase complex, class III|regulation of lipid kinase activity" "hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases NRBP1 2524.718056 2659.184637 2390.251475 0.898866307 -0.153821543 0.630111437 1 46.26531118 43.37769981 29959 nuclear receptor binding protein 1 "GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005938,GO:0006367,GO:0006468,GO:0006888,GO:0012505,GO:0016020,GO:0030027,GO:0035556,GO:0042803" protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cell cortex|transcription initiation from RNA polymerase II promoter|protein phosphorylation|endoplasmic reticulum to Golgi vesicle-mediated transport|endomembrane system|membrane|lamellipodium|intracellular signal transduction|protein homodimerization activity NRBP2 696.6544415 577.509946 815.7989369 1.412614523 0.498367834 0.187676561 1 5.861491269 8.636697705 340371 nuclear receptor binding protein 2 "GO:0004674,GO:0005524,GO:0005737,GO:0006468,GO:0006888,GO:0012505,GO:0016242,GO:0030182,GO:0035556,GO:0043524" protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|endoplasmic reticulum to Golgi vesicle-mediated transport|endomembrane system|negative regulation of macroautophagy|neuron differentiation|intracellular signal transduction|negative regulation of neuron apoptotic process NRCAM 183.5815831 257.798816 109.3643502 0.424223633 -1.237103102 0.026940318 0.724502122 0.929626242 0.411357257 4897 neuronal cell adhesion molecule "GO:0001525,GO:0001764,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007409,GO:0007411,GO:0007413,GO:0007416,GO:0007417,GO:0009897,GO:0030506,GO:0030516,GO:0043005,GO:0043194,GO:0045162,GO:0045666,GO:0098609" angiogenesis|neuron migration|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|axonogenesis|axon guidance|axonal fasciculation|synapse assembly|central nervous system development|external side of plasma membrane|ankyrin binding|regulation of axon extension|neuron projection|axon initial segment|clustering of voltage-gated sodium channels|positive regulation of neuron differentiation|cell-cell adhesion hsa04514 Cell adhesion molecules NRDC 3475.793157 3622.377851 3329.208464 0.919067143 -0.121757832 0.702338191 1 47.57797178 45.61094753 4898 nardilysin convertase "GO:0004222,GO:0005515,GO:0005739,GO:0005829,GO:0006508,GO:0009986,GO:0046872,GO:0048408,GO:0051044,GO:0052548,GO:0120163" metalloendopeptidase activity|protein binding|mitochondrion|cytosol|proteolysis|cell surface|metal ion binding|epidermal growth factor binding|positive regulation of membrane protein ectodomain proteolysis|regulation of endopeptidase activity|negative regulation of cold-induced thermogenesis NRDE2 695.7622111 718.5888256 672.9355965 0.936468217 -0.094698063 0.805281819 1 2.572013356 2.51236186 55051 "NRDE-2, necessary for RNA interference, domain containing" "GO:0003674,GO:0005515,GO:0005654,GO:0005730,GO:0016246,GO:0016607,GO:0031048,GO:0046833,GO:1902369" molecular_function|protein binding|nucleoplasm|nucleolus|RNA interference|nuclear speck|heterochromatin assembly by small RNA|positive regulation of RNA export from nucleus|negative regulation of RNA catabolic process NREP 835.7046469 1024.090572 647.3187217 0.632091281 -0.66179518 0.06967128 1 13.79063406 9.092429954 9315 neuronal regeneration related protein "GO:0005515,GO:0005634,GO:0005737,GO:0017015,GO:0031103,GO:0045664" protein binding|nucleus|cytoplasm|regulation of transforming growth factor beta receptor signaling pathway|axon regeneration|regulation of neuron differentiation NRF1 452.6018223 462.8199216 442.383723 0.955844168 -0.065152661 0.881450055 1 6.371349904 6.352350912 4899 nuclear respiratory factor 1 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007005,GO:0042803,GO:0045944,GO:0070062" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|mitochondrion organization|protein homodimerization activity|positive regulation of transcription by RNA polymerase II|extracellular exosome" "hsa04371,hsa05016" Apelin signaling pathway|Huntington disease Nrf1 NRG1 790.7563497 1015.970924 565.5417751 0.556651536 -0.845153613 0.022254778 0.64869087 3.518073512 2.042698412 3084 neuregulin 1 "GO:0000165,GO:0000187,GO:0003222,GO:0003712,GO:0005102,GO:0005125,GO:0005178,GO:0005576,GO:0005615,GO:0005654,GO:0005886,GO:0007154,GO:0007171,GO:0007399,GO:0008083,GO:0008284,GO:0014032,GO:0016020,GO:0016021,GO:0030154,GO:0030296,GO:0030297,GO:0030879,GO:0030971,GO:0031334,GO:0032148,GO:0035556,GO:0038127,GO:0038128,GO:0038129,GO:0042060,GO:0043125,GO:0045499,GO:0045892,GO:0048513,GO:0050919,GO:0051048,GO:0051155,GO:0051897,GO:0055007,GO:0060379,GO:0060956,GO:0061098,GO:2000145" "MAPK cascade|activation of MAPK activity|ventricular trabecula myocardium morphogenesis|transcription coregulator activity|signaling receptor binding|cytokine activity|integrin binding|extracellular region|extracellular space|nucleoplasm|plasma membrane|cell communication|activation of transmembrane receptor protein tyrosine kinase activity|nervous system development|growth factor activity|positive regulation of cell population proliferation|neural crest cell development|membrane|integral component of membrane|cell differentiation|protein tyrosine kinase activator activity|transmembrane receptor protein tyrosine kinase activator activity|mammary gland development|receptor tyrosine kinase binding|positive regulation of protein-containing complex assembly|activation of protein kinase B activity|intracellular signal transduction|ERBB signaling pathway|ERBB2 signaling pathway|ERBB3 signaling pathway|wound healing|ErbB-3 class receptor binding|chemorepellent activity|negative regulation of transcription, DNA-templated|animal organ development|negative chemotaxis|negative regulation of secretion|positive regulation of striated muscle cell differentiation|positive regulation of protein kinase B signaling|cardiac muscle cell differentiation|cardiac muscle cell myoblast differentiation|endocardial cell differentiation|positive regulation of protein tyrosine kinase activity|regulation of cell motility" "hsa01521,hsa04012,hsa05014" EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Amyotrophic lateral sclerosis NRG2 255.3722735 248.6642123 262.0803348 1.053952768 0.075810215 0.886474783 1 1.457128904 1.601898709 9542 neuregulin 2 "GO:0000165,GO:0005102,GO:0005576,GO:0005615,GO:0005886,GO:0007165,GO:0007399,GO:0008083,GO:0016021,GO:0035556,GO:0038128,GO:0048513,GO:0051897,GO:2000145" MAPK cascade|signaling receptor binding|extracellular region|extracellular space|plasma membrane|signal transduction|nervous system development|growth factor activity|integral component of membrane|intracellular signal transduction|ERBB2 signaling pathway|animal organ development|positive regulation of protein kinase B signaling|regulation of cell motility "hsa01521,hsa04012,hsa05014" EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Amyotrophic lateral sclerosis NRG4 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.007066157 0.004769947 145957 neuregulin 4 "GO:0000165,GO:0005515,GO:0005576,GO:0005886,GO:0007399,GO:0008083,GO:0016021,GO:0038128,GO:0051897,GO:2000145" MAPK cascade|protein binding|extracellular region|plasma membrane|nervous system development|growth factor activity|integral component of membrane|ERBB2 signaling pathway|positive regulation of protein kinase B signaling|regulation of cell motility "hsa04012,hsa05014" ErbB signaling pathway|Amyotrophic lateral sclerosis NRGN 538.2577218 492.2536447 584.261799 1.186912084 0.247213076 0.53932187 1 20.55310019 25.4455487 4900 neurogranin "GO:0005516,GO:0005547,GO:0005634,GO:0005829,GO:0007165,GO:0007399,GO:0008306,GO:0012510,GO:0014069,GO:0021537,GO:0030424,GO:0031966,GO:0043025,GO:0044327,GO:0045211,GO:0070300,GO:0098978,GO:0099170,GO:1900273" "calmodulin binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|cytosol|signal transduction|nervous system development|associative learning|trans-Golgi network transport vesicle membrane|postsynaptic density|telencephalon development|axon|mitochondrial membrane|neuronal cell body|dendritic spine head|postsynaptic membrane|phosphatidic acid binding|glutamatergic synapse|postsynaptic modulation of chemical synaptic transmission|positive regulation of long-term synaptic potentiation" NRIP1 3549.781023 3763.456731 3336.105314 0.886447103 -0.173893552 0.584926183 1 22.4824023 20.78794071 8204 nuclear receptor interacting protein 1 "GO:0000118,GO:0000122,GO:0000785,GO:0000978,GO:0001543,GO:0001650,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0007623,GO:0016607,GO:0019915,GO:0030331,GO:0032922,GO:0035257,GO:0035259,GO:0042826,GO:0045944,GO:0046965,GO:0071392" histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|ovarian follicle rupture|fibrillar center|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|circadian rhythm|nuclear speck|lipid storage|estrogen receptor binding|circadian regulation of gene expression|nuclear hormone receptor binding|glucocorticoid receptor binding|histone deacetylase binding|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|cellular response to estradiol stimulus other NRIP3 319.4265848 283.1727152 355.6804544 1.256054822 0.328899434 0.479900255 1 3.509101798 4.597486811 56675 nuclear receptor interacting protein 3 "GO:0004190,GO:0005515,GO:0006508" aspartic-type endopeptidase activity|protein binding|proteolysis NRL 21.42071737 16.23929549 26.60213925 1.638133825 0.712053221 0.528998684 1 0.147951615 0.252804627 4901 neural retina leucine zipper "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007601,GO:0043522,GO:0045944,GO:0046548,GO:0050896,GO:1990837,GO:1990841" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|visual perception|leucine zipper domain binding|positive regulation of transcription by RNA polymerase II|retinal rod cell development|response to stimulus|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" NRM 651.7897757 642.467128 661.1124235 1.0290214 0.041272986 0.918352251 1 16.40055118 17.60349009 11270 nurim "GO:0003674,GO:0005515,GO:0005635,GO:0005637,GO:0008150,GO:0016020,GO:0016021,GO:0031965" molecular_function|protein binding|nuclear envelope|nuclear inner membrane|biological_process|membrane|integral component of membrane|nuclear membrane NRN1L 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.063072318 0.255458472 123904 neuritin 1 like "GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0030424,GO:0042802,GO:0046658,GO:1990138" protein binding|extracellular region|extracellular space|plasma membrane|axon|identical protein binding|anchored component of plasma membrane|neuron projection extension NRP1 2483.533905 2807.368209 2159.699601 0.769296879 -0.378387639 0.235892484 1 23.37387736 18.75601888 8829 neuropilin 1 "GO:0001525,GO:0001569,GO:0001764,GO:0001938,GO:0002040,GO:0002042,GO:0002116,GO:0003148,GO:0005021,GO:0005096,GO:0005515,GO:0005615,GO:0005769,GO:0005829,GO:0005886,GO:0005925,GO:0006930,GO:0007165,GO:0007229,GO:0007267,GO:0007411,GO:0008201,GO:0009611,GO:0009887,GO:0009986,GO:0010595,GO:0014911,GO:0015026,GO:0016021,GO:0017154,GO:0019838,GO:0019955,GO:0021675,GO:0030424,GO:0030426,GO:0031290,GO:0031410,GO:0031532,GO:0031966,GO:0032489,GO:0034446,GO:0035729,GO:0035767,GO:0035924,GO:0038085,GO:0038189,GO:0038190,GO:0042327,GO:0043005,GO:0043025,GO:0043235,GO:0043542,GO:0043547,GO:0046718,GO:0046872,GO:0048008,GO:0048010,GO:0048012,GO:0048842,GO:0048843,GO:0048844,GO:0048846,GO:0050731,GO:0050918,GO:0051491,GO:0051496,GO:0051894,GO:0060301,GO:0060385,GO:0060627,GO:0060978,GO:0061299,GO:0061549,GO:0070374,GO:0071526,GO:0071679,GO:0090259,GO:0097102,GO:0097443,GO:0097475,GO:0097490,GO:0097491,GO:0150018,GO:0150020,GO:1900026,GO:1901166,GO:1902285,GO:1902336,GO:1902946,GO:2000251" "angiogenesis|branching involved in blood vessel morphogenesis|neuron migration|positive regulation of endothelial cell proliferation|sprouting angiogenesis|cell migration involved in sprouting angiogenesis|semaphorin receptor complex|outflow tract septum morphogenesis|vascular endothelial growth factor-activated receptor activity|GTPase activator activity|protein binding|extracellular space|early endosome|cytosol|plasma membrane|focal adhesion|substrate-dependent cell migration, cell extension|signal transduction|integrin-mediated signaling pathway|cell-cell signaling|axon guidance|heparin binding|response to wounding|animal organ morphogenesis|cell surface|positive regulation of endothelial cell migration|positive regulation of smooth muscle cell migration|coreceptor activity|integral component of membrane|semaphorin receptor activity|growth factor binding|cytokine binding|nerve development|axon|growth cone|retinal ganglion cell axon guidance|cytoplasmic vesicle|actin cytoskeleton reorganization|mitochondrial membrane|regulation of Cdc42 protein signal transduction|substrate adhesion-dependent cell spreading|cellular response to hepatocyte growth factor stimulus|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|vascular endothelial growth factor binding|neuropilin signaling pathway|VEGF-activated neuropilin signaling pathway|positive regulation of phosphorylation|neuron projection|neuronal cell body|receptor complex|endothelial cell migration|positive regulation of GTPase activity|viral entry into host cell|metal ion binding|platelet-derived growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|hepatocyte growth factor receptor signaling pathway|positive regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|artery morphogenesis|axon extension involved in axon guidance|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of filopodium assembly|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|positive regulation of cytokine activity|axonogenesis involved in innervation|regulation of vesicle-mediated transport|angiogenesis involved in coronary vascular morphogenesis|retina vasculature morphogenesis in camera-type eye|sympathetic ganglion development|positive regulation of ERK1 and ERK2 cascade|semaphorin-plexin signaling pathway|commissural neuron axon guidance|regulation of retinal ganglion cell axon guidance|endothelial tip cell fate specification|sorting endosome|motor neuron migration|sympathetic neuron projection extension|sympathetic neuron projection guidance|basal dendrite development|basal dendrite arborization|positive regulation of substrate adhesion-dependent cell spreading|neural crest cell migration involved in autonomic nervous system development|semaphorin-plexin signaling pathway involved in neuron projection guidance|positive regulation of retinal ganglion cell axon guidance|protein localization to early endosome|positive regulation of actin cytoskeleton reorganization" "hsa04360,hsa05166,hsa05171" Axon guidance|Human T-cell leukemia virus 1 infection|Coronavirus disease - COVID-19 NRP2 97.96081833 163.4079109 32.51372575 0.198972777 -2.32935704 0.001149426 0.099231339 0.508605839 0.105557946 8828 neuropilin 2 "GO:0001525,GO:0001938,GO:0002116,GO:0003148,GO:0005021,GO:0005515,GO:0005576,GO:0005886,GO:0007155,GO:0007411,GO:0008201,GO:0010595,GO:0016020,GO:0016021,GO:0016032,GO:0017154,GO:0019838,GO:0019955,GO:0021612,GO:0021649,GO:0021675,GO:0021828,GO:0030424,GO:0036486,GO:0038023,GO:0038084,GO:0046872,GO:0048010,GO:0048846,GO:0050919,GO:0061549,GO:0061551,GO:0097374,GO:0097490,GO:0097491,GO:0098978,GO:0099055,GO:0099175,GO:1901166,GO:1902285,GO:1903375,GO:1904835,GO:1990830" angiogenesis|positive regulation of endothelial cell proliferation|semaphorin receptor complex|outflow tract septum morphogenesis|vascular endothelial growth factor-activated receptor activity|protein binding|extracellular region|plasma membrane|cell adhesion|axon guidance|heparin binding|positive regulation of endothelial cell migration|membrane|integral component of membrane|viral process|semaphorin receptor activity|growth factor binding|cytokine binding|facial nerve structural organization|vestibulocochlear nerve structural organization|nerve development|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|axon|ventral trunk neural crest cell migration|signaling receptor activity|vascular endothelial growth factor signaling pathway|metal ion binding|vascular endothelial growth factor receptor signaling pathway|axon extension involved in axon guidance|negative chemotaxis|sympathetic ganglion development|trigeminal ganglion development|sensory neuron axon guidance|sympathetic neuron projection extension|sympathetic neuron projection guidance|glutamatergic synapse|integral component of postsynaptic membrane|regulation of postsynapse organization|neural crest cell migration involved in autonomic nervous system development|semaphorin-plexin signaling pathway involved in neuron projection guidance|facioacoustic ganglion development|dorsal root ganglion morphogenesis|cellular response to leukemia inhibitory factor NRROS 35.03354829 37.55337083 32.51372575 0.86580046 -0.207893528 0.852349157 1 0.744110232 0.6720027 375387 negative regulator of reactive oxygen species "GO:0005576,GO:0005783,GO:0005789,GO:0005886,GO:0006801,GO:0006954,GO:0006955,GO:0007179,GO:0009986,GO:0014005,GO:0016021,GO:0035583,GO:0036364,GO:0045087,GO:0050431" extracellular region|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|superoxide metabolic process|inflammatory response|immune response|transforming growth factor beta receptor signaling pathway|cell surface|microglia development|integral component of membrane|sequestering of TGFbeta in extracellular matrix|transforming growth factor beta1 activation|innate immune response|transforming growth factor beta binding NRSN2 1716.128469 1569.121927 1863.135012 1.187374276 0.247774763 0.44824226 1 19.01207897 23.54686939 80023 neurensin 2 "GO:0003674,GO:0005515,GO:0005886,GO:0007399,GO:0008150,GO:0016021,GO:0030133,GO:0043005,GO:0043025" molecular_function|protein binding|plasma membrane|nervous system development|biological_process|integral component of membrane|transport vesicle|neuron projection|neuronal cell body NRTN 3.47811701 2.029911937 4.926322083 2.426864926 1.279093814 0.644064692 1 0.067282643 0.17031958 4902 neurturin "GO:0000165,GO:0001755,GO:0005102,GO:0005576,GO:0007169,GO:0007399,GO:0007411,GO:0008083,GO:0021675,GO:0030116,GO:0030424,GO:0030971,GO:0031175" MAPK cascade|neural crest cell migration|signaling receptor binding|extracellular region|transmembrane receptor protein tyrosine kinase signaling pathway|nervous system development|axon guidance|growth factor activity|nerve development|glial cell-derived neurotrophic factor receptor binding|axon|receptor tyrosine kinase binding|neuron projection development NRXN3 9.553007044 13.19442759 5.911586499 0.448036602 -1.158311499 0.436032871 1 0.046555052 0.021756861 9369 neurexin 3 "GO:0005886,GO:0005887,GO:0007158,GO:0007411,GO:0007612,GO:0030534,GO:0035176,GO:0038023,GO:0046872,GO:0050839,GO:0071625,GO:0097109" plasma membrane|integral component of plasma membrane|neuron cell-cell adhesion|axon guidance|learning|adult behavior|social behavior|signaling receptor activity|metal ion binding|cell adhesion molecule binding|vocalization behavior|neuroligin family protein binding hsa04514 Cell adhesion molecules NSA2 1622.000583 1634.079109 1609.922057 0.985216718 -0.021486986 0.949821384 1 18.31791549 18.82451317 10412 NSA2 ribosome biogenesis factor "GO:0000460,GO:0000470,GO:0003723,GO:0005730,GO:0030687" "maturation of 5.8S rRNA|maturation of LSU-rRNA|RNA binding|nucleolus|preribosome, large subunit precursor" NSD1 3309.579149 3474.19428 3144.964018 0.905235506 -0.143634922 0.651919697 1 12.87355019 12.15558432 64324 nuclear receptor binding SET domain protein 1 "GO:0000122,GO:0000414,GO:0000785,GO:0000978,GO:0003682,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0008270,GO:0010452,GO:0016571,GO:0030331,GO:0033135,GO:0034770,GO:0042799,GO:0042974,GO:0045893,GO:0046965,GO:0046966,GO:0046975,GO:0050681,GO:1903025" "negative regulation of transcription by RNA polymerase II|regulation of histone H3-K36 methylation|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|chromatin binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|zinc ion binding|histone H3-K36 methylation|histone methylation|estrogen receptor binding|regulation of peptidyl-serine phosphorylation|histone H4-K20 methylation|histone methyltransferase activity (H4-K20 specific)|retinoic acid receptor binding|positive regulation of transcription, DNA-templated|retinoid X receptor binding|thyroid hormone receptor binding|histone methyltransferase activity (H3-K36 specific)|androgen receptor binding|regulation of RNA polymerase II regulatory region sequence-specific DNA binding" hsa00310 Lysine degradation NSD2 4090.500914 3716.768756 4464.233071 1.201105951 0.264363418 0.407201658 1 12.12113493 15.18589995 7468 nuclear receptor binding SET domain protein 2 "GO:0000122,GO:0000785,GO:0003149,GO:0003289,GO:0003290,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006303,GO:0006355,GO:0010452,GO:0034770,GO:0042799,GO:0043565,GO:0046872,GO:0046975,GO:0048298,GO:0060348,GO:0070201,GO:2001032" "negative regulation of transcription by RNA polymerase II|chromatin|membranous septum morphogenesis|atrial septum primum morphogenesis|atrial septum secundum morphogenesis|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|double-strand break repair via nonhomologous end joining|regulation of transcription, DNA-templated|histone H3-K36 methylation|histone H4-K20 methylation|histone methyltransferase activity (H4-K20 specific)|sequence-specific DNA binding|metal ion binding|histone methyltransferase activity (H3-K36 specific)|positive regulation of isotype switching to IgA isotypes|bone development|regulation of establishment of protein localization|regulation of double-strand break repair via nonhomologous end joining" "hsa00310,hsa05202" Lysine degradation|Transcriptional misregulation in cancer NSD3 1930.436842 1772.113121 2088.760563 1.178683538 0.237176425 0.463176778 1 7.243848097 8.905995727 54904 nuclear receptor binding SET domain protein 3 "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0010452,GO:0016571,GO:0018024,GO:0045893,GO:0046872,GO:0046975,GO:0140537,GO:2001255" "chromatin|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|histone H3-K36 methylation|histone methylation|histone-lysine N-methyltransferase activity|positive regulation of transcription, DNA-templated|metal ion binding|histone methyltransferase activity (H3-K36 specific)|transcription regulator activator activity|positive regulation of histone H3-K36 trimethylation" hsa00310 Lysine degradation NSDHL 765.7011389 717.5738696 813.8284081 1.134138857 0.181597285 0.625783542 1 20.49779191 24.2487435 50814 NAD(P) dependent steroid dehydrogenase-like "GO:0000252,GO:0001942,GO:0003854,GO:0005515,GO:0005783,GO:0005789,GO:0005811,GO:0006695,GO:0007224,GO:0008203,GO:0016021,GO:0016616,GO:0047012,GO:0055114,GO:0060716,GO:0103066,GO:0103067" "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|hair follicle development|3-beta-hydroxy-delta5-steroid dehydrogenase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cholesterol biosynthetic process|smoothened signaling pathway|cholesterol metabolic process|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity|oxidation-reduction process|labyrinthine layer blood vessel development|4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity|4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity" hsa00100 Steroid biosynthesis NSF 799.2120071 1122.541301 475.8827132 0.423933367 -1.238090573 0.000872307 0.083262293 14.27385308 6.311822137 4905 "N-ethylmaleimide sensitive factor, vesicle fusing ATPase" "GO:0000139,GO:0000149,GO:0001921,GO:0005515,GO:0005524,GO:0005765,GO:0005794,GO:0005795,GO:0005829,GO:0005886,GO:0006813,GO:0006886,GO:0006887,GO:0006888,GO:0006890,GO:0006891,GO:0014069,GO:0016192,GO:0016887,GO:0017075,GO:0017157,GO:0019901,GO:0030165,GO:0031267,GO:0035255,GO:0035494,GO:0043001,GO:0043198,GO:0044877,GO:0045026,GO:0045732,GO:0046872,GO:0048208,GO:0048211" "Golgi membrane|SNARE binding|positive regulation of receptor recycling|protein binding|ATP binding|lysosomal membrane|Golgi apparatus|Golgi stack|cytosol|plasma membrane|potassium ion transport|intracellular protein transport|exocytosis|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|postsynaptic density|vesicle-mediated transport|ATPase activity|syntaxin-1 binding|regulation of exocytosis|protein kinase binding|PDZ domain binding|small GTPase binding|ionotropic glutamate receptor binding|SNARE complex disassembly|Golgi to plasma membrane protein transport|dendritic shaft|protein-containing complex binding|plasma membrane fusion|positive regulation of protein catabolic process|metal ion binding|COPII vesicle coating|Golgi vesicle docking" "hsa04721,hsa04727,hsa04962" Synaptic vesicle cycle|GABAergic synapse|Vasopressin-regulated water reabsorption NSFL1C 3937.571399 4140.005395 3735.137403 0.902205927 -0.148471332 0.641505772 1 45.12086684 42.46186252 55968 NSFL1 cofactor "GO:0000045,GO:0000132,GO:0005515,GO:0005543,GO:0005634,GO:0005654,GO:0005694,GO:0005795,GO:0005829,GO:0005886,GO:0007030,GO:0031468,GO:0031616,GO:0043130,GO:0043161,GO:0045111,GO:0046604,GO:0051117,GO:0061025,GO:1904780,GO:1990730" autophagosome assembly|establishment of mitotic spindle orientation|protein binding|phospholipid binding|nucleus|nucleoplasm|chromosome|Golgi stack|cytosol|plasma membrane|Golgi organization|nuclear envelope reassembly|spindle pole centrosome|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|intermediate filament cytoskeleton|positive regulation of mitotic centrosome separation|ATPase binding|membrane fusion|negative regulation of protein localization to centrosome|VCP-NSFL1C complex hsa04141 Protein processing in endoplasmic reticulum NSG1 49.9636939 14.20938356 85.71800424 6.032492817 2.592754293 0.004148705 0.236266986 0.286486923 1.802675455 27065 neuronal vesicle trafficking associated 1 "GO:0001881,GO:0001921,GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005770,GO:0005783,GO:0005789,GO:0006915,GO:0007212,GO:0016021,GO:0016197,GO:0016328,GO:0030425,GO:0030659,GO:0031901,GO:0032051,GO:0032580,GO:0032585,GO:0032588,GO:0036477,GO:0042982,GO:0043202,GO:0045211,GO:0048268,GO:0055038,GO:0098814,GO:0098845,GO:0098887,GO:0098978,GO:0099003,GO:0099627,GO:0099630,GO:1900271" "receptor recycling|positive regulation of receptor recycling|signaling receptor binding|protein binding|nucleus|cytoplasm|endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum membrane|apoptotic process|dopamine receptor signaling pathway|integral component of membrane|endosomal transport|lateral plasma membrane|dendrite|cytoplasmic vesicle membrane|early endosome membrane|clathrin light chain binding|Golgi cisterna membrane|multivesicular body membrane|trans-Golgi network membrane|somatodendritic compartment|amyloid precursor protein metabolic process|lysosomal lumen|postsynaptic membrane|clathrin coat assembly|recycling endosome membrane|spontaneous synaptic transmission|postsynaptic endosome|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|vesicle-mediated transport in synapse|neurotransmitter receptor cycle|postsynaptic neurotransmitter receptor cycle|regulation of long-term synaptic potentiation" NSL1 617.4121632 616.0782728 618.7460536 1.004330263 0.006233761 0.991939485 1 2.067739637 2.166149026 25936 NSL1 component of MIS12 kinetochore complex "GO:0000070,GO:0000444,GO:0000777,GO:0005515,GO:0005829,GO:0016607,GO:0051301" mitotic sister chromatid segregation|MIS12/MIND type complex|condensed chromosome kinetochore|protein binding|cytosol|nuclear speck|cell division NSMAF 1739.072858 1756.888781 1721.256936 0.979718781 -0.029560398 0.929551666 1 23.47143731 23.98595687 8439 neutral sphingomyelinase activation associated factor "GO:0005515,GO:0005737,GO:0005829,GO:0006672,GO:0007165,GO:0016230,GO:0043065,GO:0050790,GO:2000304" protein binding|cytoplasm|cytosol|ceramide metabolic process|signal transduction|sphingomyelin phosphodiesterase activator activity|positive regulation of apoptotic process|regulation of catalytic activity|positive regulation of ceramide biosynthetic process hsa04071 Sphingolipid signaling pathway NSMCE1 586.8783689 684.0803227 489.676415 0.715817133 -0.482337021 0.219836344 1 19.55206267 14.59857949 197370 "NSE1 homolog, SMC5-SMC6 complex component" "GO:0000724,GO:0000781,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0006301,GO:0016567,GO:0030915,GO:0035556,GO:0043231,GO:0046872,GO:0046983,GO:0061630,GO:2001022" "double-strand break repair via homologous recombination|chromosome, telomeric region|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|postreplication repair|protein ubiquitination|Smc5-Smc6 complex|intracellular signal transduction|intracellular membrane-bounded organelle|metal ion binding|protein dimerization activity|ubiquitin protein ligase activity|positive regulation of response to DNA damage stimulus" NSMCE2 990.7353347 1013.941012 967.529657 0.95422677 -0.067595935 0.850600572 1 12.10003188 12.0435367 286053 "NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase" "GO:0000722,GO:0000724,GO:0000781,GO:0005515,GO:0005634,GO:0005654,GO:0006303,GO:0007049,GO:0008270,GO:0016604,GO:0016605,GO:0016925,GO:0019789,GO:0030915,GO:0034184,GO:0045842,GO:0051301,GO:0061665,GO:0090398" "telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, telomeric region|protein binding|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|cell cycle|zinc ion binding|nuclear body|PML body|protein sumoylation|SUMO transferase activity|Smc5-Smc6 complex|positive regulation of maintenance of mitotic sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|cell division|SUMO ligase activity|cellular senescence" NSMCE3 324.124777 334.9354696 313.3140845 0.935446117 -0.09627354 0.840590361 1 3.509164243 3.424036628 56160 "NSE3 homolog, SMC5-SMC6 complex component" "GO:0000781,GO:0005515,GO:0005654,GO:0005737,GO:0006281,GO:0006310,GO:0030915,GO:0031398,GO:0034644,GO:0040008,GO:0046983,GO:0071478,GO:0072711" "chromosome, telomeric region|protein binding|nucleoplasm|cytoplasm|DNA repair|DNA recombination|Smc5-Smc6 complex|positive regulation of protein ubiquitination|cellular response to UV|regulation of growth|protein dimerization activity|cellular response to radiation|cellular response to hydroxyurea" NSMCE4A 367.1822174 281.1428032 453.2216316 1.612069121 0.688913604 0.121700181 1 6.48992305 10.91287389 54780 "NSE4 homolog A, SMC5-SMC6 complex component" "GO:0000781,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0016604,GO:0030915,GO:2001022" "chromosome, telomeric region|protein binding|nucleus|nucleoplasm|DNA repair|DNA recombination|nuclear body|Smc5-Smc6 complex|positive regulation of response to DNA damage stimulus" NSMF 1911.19301 1972.059447 1850.326574 0.938271195 -0.091923119 0.777309596 1 26.57032561 26.00406184 26012 NMDA receptor synaptonuclear signaling and neuronal migration factor "GO:0000791,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005886,GO:0014069,GO:0016020,GO:0016363,GO:0030425,GO:0030863,GO:0031965,GO:0035307,GO:0043005,GO:0043204,GO:0043523,GO:0045202,GO:0048168,GO:0048306,GO:0048814,GO:0071230,GO:0071257,GO:0071371,GO:0097440,GO:2001224" euchromatin|nucleus|nuclear envelope|nucleoplasm|cytoplasm|plasma membrane|postsynaptic density|membrane|nuclear matrix|dendrite|cortical cytoskeleton|nuclear membrane|positive regulation of protein dephosphorylation|neuron projection|perikaryon|regulation of neuron apoptotic process|synapse|regulation of neuronal synaptic plasticity|calcium-dependent protein binding|regulation of dendrite morphogenesis|cellular response to amino acid stimulus|cellular response to electrical stimulus|cellular response to gonadotropin stimulus|apical dendrite|positive regulation of neuron migration NSRP1 493.6630017 541.9864871 445.3395163 0.82168011 -0.283351251 0.490689251 1 13.1024838 11.22980811 84081 nuclear speckle splicing regulatory protein 1 "GO:0000381,GO:0001701,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0016607,GO:0032502,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|in utero embryonic development|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|nuclear speck|developmental process|ribonucleoprotein complex" NSUN2 3306.789134 3822.324177 2791.254092 0.730250487 -0.453536679 0.154270119 1 63.34660838 48.25153707 54888 NOP2/Sun RNA methyltransferase 2 "GO:0000049,GO:0001510,GO:0001701,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005819,GO:0006400,GO:0007286,GO:0008168,GO:0010793,GO:0016428,GO:0030488,GO:0033313,GO:0033391,GO:0036416,GO:0048820,GO:0051301,GO:0062152,GO:0070062,GO:0080009,GO:2000736" tRNA binding|RNA methylation|in utero embryonic development|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|spindle|tRNA modification|spermatid development|methyltransferase activity|regulation of mRNA export from nucleus|tRNA (cytosine-5-)-methyltransferase activity|tRNA methylation|meiotic cell cycle checkpoint|chromatoid body|tRNA stabilization|hair follicle maturation|cell division|mRNA (cytidine-5-)-methyltransferase activity|extracellular exosome|mRNA methylation|regulation of stem cell differentiation NSUN3 182.1833586 195.8865019 168.4802152 0.860090989 -0.217438804 0.701628094 1 1.569027404 1.407637592 63899 NOP2/Sun RNA methyltransferase 3 "GO:0000049,GO:0001510,GO:0002127,GO:0005739,GO:0005759,GO:0005762,GO:0008168,GO:0016428,GO:0031167,GO:0070129" tRNA binding|RNA methylation|tRNA wobble base cytosine methylation|mitochondrion|mitochondrial matrix|mitochondrial large ribosomal subunit|methyltransferase activity|tRNA (cytosine-5-)-methyltransferase activity|rRNA methylation|regulation of mitochondrial translation NSUN4 591.1541984 605.9287131 576.3796837 0.951233489 -0.072128588 0.857980651 1 4.113141902 4.081095466 387338 NOP2/Sun RNA methyltransferase 4 "GO:0001510,GO:0005515,GO:0005759,GO:0005762,GO:0008168,GO:0009383,GO:0019843,GO:0031167" RNA methylation|protein binding|mitochondrial matrix|mitochondrial large ribosomal subunit|methyltransferase activity|rRNA (cytosine-C5-)-methyltransferase activity|rRNA binding|rRNA methylation NSUN5 366.3696591 360.3093688 372.4299495 1.033639371 0.047732929 0.920772386 1 7.597168374 8.190996204 55695 NOP2/Sun RNA methyltransferase 5 "GO:0001510,GO:0003723,GO:0005654,GO:0005730,GO:0009383,GO:0014003,GO:0021987,GO:0022038,GO:0031641,GO:0045727,GO:0050890,GO:0070475" RNA methylation|RNA binding|nucleoplasm|nucleolus|rRNA (cytosine-C5-)-methyltransferase activity|oligodendrocyte development|cerebral cortex development|corpus callosum development|regulation of myelination|positive regulation of translation|cognition|rRNA base methylation NSUN6 176.9870909 211.1108414 142.8633404 0.676721951 -0.563364909 0.316107892 1 3.340212235 2.357763586 221078 NOP2/Sun RNA methyltransferase 6 "GO:0000049,GO:0001510,GO:0002946,GO:0005737,GO:0005829,GO:0006400,GO:0016428,GO:0030488" tRNA binding|RNA methylation|tRNA C5-cytosine methylation|cytoplasm|cytosol|tRNA modification|tRNA (cytosine-5-)-methyltransferase activity|tRNA methylation NT5C 796.5358081 804.8600829 788.2115332 0.979314977 -0.030155147 0.938184016 1 36.26630233 37.04602399 30833 "5', 3'-nucleotidase, cytosolic" "GO:0005634,GO:0005737,GO:0005829,GO:0006195,GO:0006204,GO:0008252,GO:0008253,GO:0009223,GO:0016311,GO:0019103,GO:0042802,GO:0046050,GO:0046055,GO:0046074,GO:0046079,GO:0046135,GO:0046872,GO:0050483,GO:0070062" nucleus|cytoplasm|cytosol|purine nucleotide catabolic process|IMP catabolic process|nucleotidase activity|5'-nucleotidase activity|pyrimidine deoxyribonucleotide catabolic process|dephosphorylation|pyrimidine nucleotide binding|identical protein binding|UMP catabolic process|dGMP catabolic process|dTMP catabolic process|dUMP catabolic process|pyrimidine nucleoside catabolic process|metal ion binding|IMP 5'-nucleotidase activity|extracellular exosome "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5C1A 13.94215959 10.14955968 17.7347595 1.747342747 0.805162625 0.540804743 1 0.056687185 0.103318697 84618 "5'-nucleotidase, cytosolic IA" "GO:0000166,GO:0000287,GO:0005515,GO:0005829,GO:0006195,GO:0008253,GO:0009116,GO:0009128,GO:0016311,GO:0046085,GO:0046135" nucleotide binding|magnesium ion binding|protein binding|cytosol|purine nucleotide catabolic process|5'-nucleotidase activity|nucleoside metabolic process|purine nucleoside monophosphate catabolic process|dephosphorylation|adenosine metabolic process|pyrimidine nucleoside catabolic process "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5C2 3925.344915 3775.636202 4075.053627 1.079302509 0.110099283 0.730083546 1 32.17611543 36.22369327 22978 "5'-nucleotidase, cytosolic II" "GO:0000166,GO:0005515,GO:0005829,GO:0006195,GO:0008253,GO:0016311,GO:0017144,GO:0046040,GO:0046085,GO:0046872" nucleotide binding|protein binding|cytosol|purine nucleotide catabolic process|5'-nucleotidase activity|dephosphorylation|drug metabolic process|IMP metabolic process|adenosine metabolic process|metal ion binding "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5C3A 395.7588449 416.131947 375.3857427 0.902083451 -0.148667193 0.736426167 1 11.36151757 10.69052392 51251 "5'-nucleotidase, cytosolic IIIA" "GO:0000166,GO:0000215,GO:0000287,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0006213,GO:0008253,GO:0009117,GO:0016311,GO:0046135,GO:0051607" nucleotide binding|tRNA 2'-phosphotransferase activity|magnesium ion binding|protein binding|cytoplasm|endoplasmic reticulum|cytosol|pyrimidine nucleoside metabolic process|5'-nucleotidase activity|nucleotide metabolic process|dephosphorylation|pyrimidine nucleoside catabolic process|defense response to virus "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism NT5C3B 1213.629017 1197.648043 1229.609992 1.026687264 0.037996793 0.913777488 1 37.1215718 39.75396592 115024 "5'-nucleotidase, cytosolic IIIB" "GO:0000166,GO:0000287,GO:0005515,GO:0005737,GO:0005829,GO:0008253,GO:0009117,GO:0016311,GO:0043928" nucleotide binding|magnesium ion binding|protein binding|cytoplasm|cytosol|5'-nucleotidase activity|nucleotide metabolic process|dephosphorylation|exonucleolytic catabolism of deadenylated mRNA "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism NT5DC1 570.1842975 553.1510028 587.2175923 1.061586419 0.08622182 0.831248754 1 3.671709946 4.065740442 221294 5'-nucleotidase domain containing 1 "GO:0008253,GO:0016311,GO:0046872" 5'-nucleotidase activity|dephosphorylation|metal ion binding NT5DC2 3175.137569 3814.204529 2536.070608 0.664901577 -0.588787294 0.064716957 1 68.38088626 47.42507412 64943 5'-nucleotidase domain containing 2 "GO:0008253,GO:0016311,GO:0046872" 5'-nucleotidase activity|dephosphorylation|metal ion binding NT5DC3 228.5622934 234.4548287 222.6697581 0.949734153 -0.07440436 0.893549006 1 1.329412222 1.316975369 51559 5'-nucleotidase domain containing 3 "GO:0008253,GO:0016311,GO:0043235,GO:0046872" 5'-nucleotidase activity|dephosphorylation|receptor complex|metal ion binding NT5E 3663.918286 3079.376408 4248.460164 1.379649514 0.464301811 0.14506116 1 43.78426493 63.0090258 4907 5'-nucleotidase ecto "GO:0000166,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006195,GO:0006196,GO:0006259,GO:0007159,GO:0008253,GO:0009897,GO:0009986,GO:0016020,GO:0016311,GO:0019674,GO:0031225,GO:0046086,GO:0046135,GO:0046872,GO:0050728,GO:0070062" nucleotide binding|protein binding|nucleoplasm|cytosol|plasma membrane|purine nucleotide catabolic process|AMP catabolic process|DNA metabolic process|leukocyte cell-cell adhesion|5'-nucleotidase activity|external side of plasma membrane|cell surface|membrane|dephosphorylation|NAD metabolic process|anchored component of membrane|adenosine biosynthetic process|pyrimidine nucleoside catabolic process|metal ion binding|negative regulation of inflammatory response|extracellular exosome "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5M 34.98901096 34.50850292 35.469519 1.027848675 0.039627879 1 1 0.625531115 0.670647063 56953 "5',3'-nucleotidase, mitochondrial" "GO:0000166,GO:0005739,GO:0005759,GO:0006260,GO:0008252,GO:0008253,GO:0009223,GO:0016311,GO:0046135,GO:0046872" nucleotide binding|mitochondrion|mitochondrial matrix|DNA replication|nucleotidase activity|5'-nucleotidase activity|pyrimidine deoxyribonucleotide catabolic process|dephosphorylation|pyrimidine nucleoside catabolic process|metal ion binding "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NTAN1 854.1346823 734.8281211 973.4412435 1.324719639 0.405687063 0.263498518 1 24.54911083 33.92154864 123803 N-terminal asparagine amidase "GO:0005515,GO:0005634,GO:0005737,GO:0006511,GO:0008418" protein binding|nucleus|cytoplasm|ubiquitin-dependent protein catabolic process|protein-N-terminal asparagine amidohydrolase activity NTAQ1 548.2412564 534.8817953 561.6007174 1.049952947 0.070324676 0.864389927 1 3.940345598 4.3153903 55093 N-terminal glutamine amidase 1 "GO:0005515,GO:0005634,GO:0005829,GO:0006464,GO:0008418,GO:0070773" protein binding|nucleus|cytosol|cellular protein modification process|protein-N-terminal asparagine amidohydrolase activity|protein-N-terminal glutamine amidohydrolase activity NTF4 5.463491619 3.044867905 7.882115332 2.588655921 1.372203218 0.484534422 1 0.065818104 0.177719722 4909 neurotrophin 4 "GO:0005163,GO:0005515,GO:0005576,GO:0005615,GO:0007169,GO:0007202,GO:0007402,GO:0007422,GO:0007613,GO:0007616,GO:0008021,GO:0008052,GO:0008083,GO:0008344,GO:0008544,GO:0021675,GO:0030424,GO:0030425,GO:0033138,GO:0038180,GO:0042490,GO:0043524,GO:0045664,GO:0048011,GO:0048812,GO:0050804,GO:0060384,GO:0061193" nerve growth factor receptor binding|protein binding|extracellular region|extracellular space|transmembrane receptor protein tyrosine kinase signaling pathway|activation of phospholipase C activity|ganglion mother cell fate determination|peripheral nervous system development|memory|long-term memory|synaptic vesicle|sensory organ boundary specification|growth factor activity|adult locomotory behavior|epidermis development|nerve development|axon|dendrite|positive regulation of peptidyl-serine phosphorylation|nerve growth factor signaling pathway|mechanoreceptor differentiation|negative regulation of neuron apoptotic process|regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|neuron projection morphogenesis|modulation of chemical synaptic transmission|innervation|taste bud development "hsa04010,hsa04014,hsa04151,hsa04722" MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Neurotrophin signaling pathway NTHL1 226.5917646 234.4548287 218.7287005 0.932924699 -0.100167456 0.854154039 1 11.52845628 11.21847121 4913 nth like DNA glycosylase 1 "GO:0000703,GO:0003690,GO:0003906,GO:0004519,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006285,GO:0006296,GO:0008534,GO:0019104,GO:0045008,GO:0046872,GO:0051539,GO:0140078" "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|double-stranded DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|endonuclease activity|protein binding|nucleus|nucleoplasm|mitochondrion|base-excision repair, AP site formation|nucleotide-excision repair, DNA incision, 5'-to lesion|oxidized purine nucleobase lesion DNA N-glycosylase activity|DNA N-glycosylase activity|depyrimidination|metal ion binding|4 iron, 4 sulfur cluster binding|class I DNA-(apurinic or apyrimidinic site) endonuclease activity" hsa03410 Base excision repair NTM 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.016409877 0.024924021 50863 neurotrimin "GO:0005515,GO:0005576,GO:0005886,GO:0007155,GO:0008038,GO:0031225" protein binding|extracellular region|plasma membrane|cell adhesion|neuron recognition|anchored component of membrane NTMT1 722.933933 690.1700585 755.6978075 1.094944352 0.13085755 0.729590659 1 23.97440239 27.38140745 28989 N-terminal Xaa-Pro-Lys N-methyltransferase 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006480,GO:0007051,GO:0007059,GO:0008168,GO:0008276,GO:0016571,GO:0018011,GO:0018012,GO:0018013,GO:0018016,GO:0035568,GO:0035570,GO:0035572,GO:0035573,GO:0042054,GO:0071885" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|N-terminal protein amino acid methylation|spindle organization|chromosome segregation|methyltransferase activity|protein methyltransferase activity|histone methylation|N-terminal peptidyl-alanine methylation|N-terminal peptidyl-alanine trimethylation|N-terminal peptidyl-glycine methylation|N-terminal peptidyl-proline dimethylation|N-terminal peptidyl-proline methylation|N-terminal peptidyl-serine methylation|N-terminal peptidyl-serine dimethylation|N-terminal peptidyl-serine trimethylation|histone methyltransferase activity|N-terminal protein N-methyltransferase activity NTN1 401.7473819 387.7131799 415.7815838 1.072394763 0.100836079 0.820689725 1 9.288696685 10.39023561 9423 netrin 1 "GO:0001764,GO:0005515,GO:0005576,GO:0005604,GO:0005737,GO:0006915,GO:0006930,GO:0007097,GO:0007265,GO:0008045,GO:0008284,GO:0009887,GO:0009888,GO:0016358,GO:0030334,GO:0030517,GO:0032488,GO:0033564,GO:0042472,GO:0045773,GO:0051963,GO:0060603,GO:0061643,GO:0098609,GO:1902842,GO:2000147" "neuron migration|protein binding|extracellular region|basement membrane|cytoplasm|apoptotic process|substrate-dependent cell migration, cell extension|nuclear migration|Ras protein signal transduction|motor neuron axon guidance|positive regulation of cell population proliferation|animal organ morphogenesis|tissue development|dendrite development|regulation of cell migration|negative regulation of axon extension|Cdc42 protein signal transduction|anterior/posterior axon guidance|inner ear morphogenesis|positive regulation of axon extension|regulation of synapse assembly|mammary gland duct morphogenesis|chemorepulsion of axon|cell-cell adhesion|negative regulation of netrin-activated signaling pathway|positive regulation of cell motility" hsa04360 Axon guidance NTN4 271.017738 240.5445645 301.4909115 1.253368215 0.325810313 0.506986317 1 2.989627878 3.908514624 59277 netrin 4 "GO:0005515,GO:0005886,GO:0007411,GO:0009887,GO:0009888,GO:0016322,GO:0016477,GO:0034446,GO:0043237,GO:0043256,GO:0060668,GO:0070831" protein binding|plasma membrane|axon guidance|animal organ morphogenesis|tissue development|neuron remodeling|cell migration|substrate adhesion-dependent cell spreading|laminin-1 binding|laminin complex|regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling|basement membrane assembly hsa04360 Axon guidance NTN5 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.033531598 0.067905628 126147 netrin 5 "GO:0005102,GO:0005604,GO:0008045,GO:0009887,GO:0009888,GO:0016358,GO:0022008" signaling receptor binding|basement membrane|motor neuron axon guidance|animal organ morphogenesis|tissue development|dendrite development|neurogenesis NTNG1 26.54003454 29.43372308 23.646346 0.803375976 -0.315852776 0.785664681 1 0.203677311 0.170677952 22854 netrin G1 "GO:0005515,GO:0005576,GO:0005886,GO:0007409,GO:0009887,GO:0009888,GO:0010975,GO:0016477,GO:0034446,GO:0043256,GO:0046658,GO:0050804,GO:0050839,GO:0070831,GO:0098632,GO:0098685,GO:0098978,GO:0099029,GO:0099560,GO:0150011,GO:2001222" protein binding|extracellular region|plasma membrane|axonogenesis|animal organ morphogenesis|tissue development|regulation of neuron projection development|cell migration|substrate adhesion-dependent cell spreading|laminin complex|anchored component of plasma membrane|modulation of chemical synaptic transmission|cell adhesion molecule binding|basement membrane assembly|cell-cell adhesion mediator activity|Schaffer collateral - CA1 synapse|glutamatergic synapse|anchored component of presynaptic active zone membrane|synaptic membrane adhesion|regulation of neuron projection arborization|regulation of neuron migration "hsa04360,hsa04514" Axon guidance|Cell adhesion molecules NTNG2 4.52276453 6.08973581 2.95579325 0.485372985 -1.042834281 0.660953233 1 0.040049816 0.020276456 84628 netrin G2 "GO:0003674,GO:0005515,GO:0005576,GO:0005886,GO:0007409,GO:0009887,GO:0009888,GO:0010975,GO:0016477,GO:0030424,GO:0034446,GO:0043256,GO:0045171,GO:0046658,GO:0050804,GO:0070831,GO:0090543,GO:0098685,GO:0098698,GO:0098978,GO:0099029,GO:0099560,GO:0150011,GO:1905606,GO:2001222" molecular_function|protein binding|extracellular region|plasma membrane|axonogenesis|animal organ morphogenesis|tissue development|regulation of neuron projection development|cell migration|axon|substrate adhesion-dependent cell spreading|laminin complex|intercellular bridge|anchored component of plasma membrane|modulation of chemical synaptic transmission|basement membrane assembly|Flemming body|Schaffer collateral - CA1 synapse|postsynaptic specialization assembly|glutamatergic synapse|anchored component of presynaptic active zone membrane|synaptic membrane adhesion|regulation of neuron projection arborization|regulation of presynapse assembly|regulation of neuron migration "hsa04360,hsa04514" Axon guidance|Cell adhesion molecules NTPCR 705.6984867 791.6656553 619.731318 0.782819507 -0.353248388 0.349130757 1 6.34014431 5.176982681 84284 "nucleoside-triphosphatase, cancer-related" "GO:0003723,GO:0005524,GO:0016020,GO:0017111" RNA binding|ATP binding|membrane|nucleoside-triphosphatase activity "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism NTRK1 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.089522709 0.036258909 4914 neurotrophic receptor tyrosine kinase 1 "GO:0000139,GO:0000186,GO:0001934,GO:0004713,GO:0004714,GO:0005004,GO:0005030,GO:0005166,GO:0005515,GO:0005524,GO:0005769,GO:0005770,GO:0005886,GO:0005887,GO:0006468,GO:0007169,GO:0007275,GO:0007411,GO:0007568,GO:0007611,GO:0007623,GO:0008285,GO:0009314,GO:0009986,GO:0010008,GO:0010465,GO:0010623,GO:0010976,GO:0014068,GO:0018108,GO:0019900,GO:0021553,GO:0030183,GO:0030424,GO:0030425,GO:0031667,GO:0031901,GO:0031902,GO:0032991,GO:0033674,GO:0038083,GO:0038180,GO:0042490,GO:0042493,GO:0042802,GO:0042803,GO:0043025,GO:0043066,GO:0043068,GO:0043121,GO:0043235,GO:0043410,GO:0043524,GO:0043547,GO:0046579,GO:0046777,GO:0048011,GO:0048013,GO:0048015,GO:0048406,GO:0048485,GO:0048678,GO:0050965,GO:0050966,GO:0051092,GO:0051599,GO:0051602,GO:0051896,GO:0051965,GO:0051968,GO:0055038,GO:0060009,GO:0060385,GO:0061368,GO:0070374,GO:0071316,GO:1904646,GO:1990090" "Golgi membrane|activation of MAPKK activity|positive regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|GPI-linked ephrin receptor activity|neurotrophin receptor activity|neurotrophin p75 receptor binding|protein binding|ATP binding|early endosome|late endosome|plasma membrane|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|aging|learning or memory|circadian rhythm|negative regulation of cell population proliferation|response to radiation|cell surface|endosome membrane|nerve growth factor receptor activity|programmed cell death involved in cell development|positive regulation of neuron projection development|positive regulation of phosphatidylinositol 3-kinase signaling|peptidyl-tyrosine phosphorylation|kinase binding|olfactory nerve development|B cell differentiation|axon|dendrite|response to nutrient levels|early endosome membrane|late endosome membrane|protein-containing complex|positive regulation of kinase activity|peptidyl-tyrosine autophosphorylation|nerve growth factor signaling pathway|mechanoreceptor differentiation|response to drug|identical protein binding|protein homodimerization activity|neuronal cell body|negative regulation of apoptotic process|positive regulation of programmed cell death|neurotrophin binding|receptor complex|positive regulation of MAPK cascade|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|positive regulation of Ras protein signal transduction|protein autophosphorylation|neurotrophin TRK receptor signaling pathway|ephrin receptor signaling pathway|phosphatidylinositol-mediated signaling|nerve growth factor binding|sympathetic nervous system development|response to axon injury|detection of temperature stimulus involved in sensory perception of pain|detection of mechanical stimulus involved in sensory perception of pain|positive regulation of NF-kappaB transcription factor activity|response to hydrostatic pressure|response to electrical stimulus|regulation of protein kinase B signaling|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|recycling endosome membrane|Sertoli cell development|axonogenesis involved in innervation|behavioral response to formalin induced pain|positive regulation of ERK1 and ERK2 cascade|cellular response to nicotine|cellular response to amyloid-beta|cellular response to nerve growth factor stimulus" "hsa04010,hsa04014,hsa04020,hsa04151,hsa04210,hsa04722,hsa04750,hsa05200,hsa05202,hsa05216,hsa05230" MAPK signaling pathway|Ras signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Central carbon metabolism in cancer NTS 6.419064483 1.014955968 11.823173 11.64895165 3.542128219 0.075977894 1 0.041488248 0.504112966 4922 neurotensin "GO:0005184,GO:0005515,GO:0005576,GO:0007165,GO:0007186,GO:0007218,GO:0030133,GO:0043231,GO:0043679,GO:0048018,GO:0071855" neuropeptide hormone activity|protein binding|extracellular region|signal transduction|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|transport vesicle|intracellular membrane-bounded organelle|axon terminus|receptor ligand activity|neuropeptide receptor binding hsa04080 Neuroactive ligand-receptor interaction NUAK1 926.9591339 863.7275291 990.1907386 1.146415629 0.197130183 0.582129638 1 7.615729857 9.106878835 9891 NUAK family kinase 1 "GO:0001650,GO:0002039,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0006974,GO:0007155,GO:0015630,GO:0030155,GO:0035507,GO:0035556,GO:0042127,GO:0042149,GO:0046872,GO:0106310,GO:0106311,GO:1901796,GO:2000772" fibrillar center|p53 binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|cellular response to DNA damage stimulus|cell adhesion|microtubule cytoskeleton|regulation of cell adhesion|regulation of myosin-light-chain-phosphatase activity|intracellular signal transduction|regulation of cell population proliferation|cellular response to glucose starvation|metal ion binding|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|regulation of cellular senescence NUAK2 474.3761167 536.9117073 411.8405261 0.767054472 -0.382599061 0.356058556 1 7.758255025 6.207349338 81788 NUAK family kinase 2 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0006915,GO:0030036,GO:0035556,GO:0042149,GO:0043066,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|apoptotic process|actin cytoskeleton organization|intracellular signal transduction|cellular response to glucose starvation|negative regulation of apoptotic process|protein serine kinase activity|protein threonine kinase activity NUB1 991.7908687 884.0266485 1099.555089 1.243803103 0.314758122 0.372722657 1 13.18787366 17.109698 51667 negative regulator of ubiquitin like proteins 1 "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006511,GO:0016567,GO:0032436,GO:0034341,GO:0034612,GO:0043687,GO:2000058" protein binding|nucleoplasm|nucleolus|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|response to interferon-gamma|response to tumor necrosis factor|post-translational protein modification|regulation of ubiquitin-dependent protein catabolic process NUBP1 313.7795006 334.9354696 292.6235317 0.873671373 -0.194837375 0.679969203 1 8.876661409 8.089351188 4682 nucleotide binding protein 1 "GO:0000166,GO:0001558,GO:0005515,GO:0005524,GO:0005634,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0006879,GO:0010826,GO:0016226,GO:0030030,GO:0046872,GO:0051536,GO:0051539,GO:0051642,GO:0072697" "nucleotide binding|regulation of cell growth|protein binding|ATP binding|nucleus|centriole|cytosol|plasma membrane|cilium|cellular iron ion homeostasis|negative regulation of centrosome duplication|iron-sulfur cluster assembly|cell projection organization|metal ion binding|iron-sulfur cluster binding|4 iron, 4 sulfur cluster binding|centrosome localization|protein localization to cell cortex" NUBP2 641.0409418 648.5568638 633.5250198 0.976822628 -0.033831475 0.93418027 1 11.63141543 11.85125133 10101 nucleotide binding protein 2 "GO:0000166,GO:0005515,GO:0005524,GO:0005634,GO:0005814,GO:0005829,GO:0005929,GO:0016226,GO:0030030,GO:0031616,GO:0046872,GO:0051536,GO:0051539" "nucleotide binding|protein binding|ATP binding|nucleus|centriole|cytosol|cilium|iron-sulfur cluster assembly|cell projection organization|spindle pole centrosome|metal ion binding|iron-sulfur cluster binding|4 iron, 4 sulfur cluster binding" NUBPL 338.9064649 301.4419226 376.3710071 1.248568891 0.320275426 0.483542809 1 1.097711386 1.429606812 80224 nucleotide binding protein like "GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005886,GO:0016226,GO:0032981,GO:0046872,GO:0051539,GO:0070584" "protein binding|ATP binding|mitochondrion|mitochondrial matrix|plasma membrane|iron-sulfur cluster assembly|mitochondrial respiratory chain complex I assembly|metal ion binding|4 iron, 4 sulfur cluster binding|mitochondrion morphogenesis" NUCB1 5102.13588 4913.401843 5290.869917 1.076824181 0.106782713 0.740020343 1 96.04263601 107.8759916 4924 nucleobindin 1 "GO:0001965,GO:0003677,GO:0005085,GO:0005509,GO:0005515,GO:0005615,GO:0005634,GO:0005769,GO:0005788,GO:0005791,GO:0005793,GO:0005798,GO:0005801,GO:0005802,GO:0007264,GO:0016020,GO:0032580,GO:0043687,GO:0044267,GO:0050790,GO:0070062,GO:0072718,GO:0090498,GO:0098547,GO:1903533" G-protein alpha-subunit binding|DNA binding|guanyl-nucleotide exchange factor activity|calcium ion binding|protein binding|extracellular space|nucleus|early endosome|endoplasmic reticulum lumen|rough endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi-associated vesicle|cis-Golgi network|trans-Golgi network|small GTPase mediated signal transduction|membrane|Golgi cisterna membrane|post-translational protein modification|cellular protein metabolic process|regulation of catalytic activity|extracellular exosome|response to cisplatin|extrinsic component of Golgi membrane|lumenal side of Golgi membrane|regulation of protein targeting NUCB2 823.8505446 853.5779694 794.1231197 0.930346317 -0.104160243 0.777933559 1 11.44881168 11.11017716 4925 nucleobindin 2 "GO:0001965,GO:0003677,GO:0005085,GO:0005509,GO:0005515,GO:0005615,GO:0005635,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0005886,GO:0007264,GO:0032099,GO:0050790,GO:0070062" G-protein alpha-subunit binding|DNA binding|guanyl-nucleotide exchange factor activity|calcium ion binding|protein binding|extracellular space|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|plasma membrane|small GTPase mediated signal transduction|negative regulation of appetite|regulation of catalytic activity|extracellular exosome NUCKS1 9610.001924 8064.840125 11155.16372 1.383184732 0.467993849 0.163472406 1 63.48394487 91.59252292 64710 nuclear casein kinase and cyclin dependent kinase substrate 1 "GO:0000724,GO:0000785,GO:0001678,GO:0003682,GO:0003690,GO:0003697,GO:0003713,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006275,GO:0006325,GO:0006357,GO:0008134,GO:0019046,GO:0031297,GO:0035822,GO:0036297,GO:0043923,GO:0044829,GO:0045944,GO:0046626,GO:0046628,GO:0060382,GO:0071481,GO:1990968,GO:1990969" double-strand break repair via homologous recombination|chromatin|cellular glucose homeostasis|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|transcription coactivator activity|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|regulation of DNA replication|chromatin organization|regulation of transcription by RNA polymerase II|transcription factor binding|release from viral latency|replication fork processing|gene conversion|interstrand cross-link repair|positive regulation by host of viral transcription|positive regulation by host of viral genome replication|positive regulation of transcription by RNA polymerase II|regulation of insulin receptor signaling pathway|positive regulation of insulin receptor signaling pathway|regulation of DNA strand elongation|cellular response to X-ray|modulation by host of RNA binding by virus|modulation by host of viral RNA-binding transcription factor activity NUDC 2414.242994 2549.569393 2278.916595 0.893843722 -0.16190548 0.612594904 1 58.64064278 54.6734206 10726 "nuclear distribution C, dynein complex regulator" "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0006457,GO:0007052,GO:0007080,GO:0030496,GO:0032502,GO:0045296,GO:0051082,GO:0051301,GO:0072686" protein binding|nucleoplasm|cytoplasm|cytosol|microtubule|protein folding|mitotic spindle organization|mitotic metaphase plate congression|midbody|developmental process|cadherin binding|unfolded protein binding|cell division|mitotic spindle NUDCD1 2018.95946 1795.457108 2242.461812 1.24896429 0.320732228 0.319419276 1 22.21142368 28.93625662 84955 NudC domain containing 1 "GO:0002376,GO:0005515,GO:0005654,GO:0005829" immune system process|protein binding|nucleoplasm|cytosol NUDCD2 520.9507682 555.1809147 486.7206218 0.876688317 -0.189864072 0.641099989 1 3.18292447 2.910633221 134492 NudC domain containing 2 "GO:0000777,GO:0000922,GO:0005515,GO:0005737,GO:0005815,GO:0005829,GO:0006457,GO:0015630,GO:0032502,GO:0045171,GO:0051082,GO:0072686" condensed chromosome kinetochore|spindle pole|protein binding|cytoplasm|microtubule organizing center|cytosol|protein folding|microtubule cytoskeleton|developmental process|intercellular bridge|unfolded protein binding|mitotic spindle NUDCD3 3114.985713 2968.746207 3261.225219 1.098519372 0.135560311 0.670409108 1 16.78835667 19.23675602 23386 NudC domain containing 3 "GO:0005515,GO:0005737,GO:0005868,GO:0006457,GO:0032502,GO:0051082,GO:0060271,GO:1905793" protein binding|cytoplasm|cytoplasmic dynein complex|protein folding|developmental process|unfolded protein binding|cilium assembly|protein localization to pericentriolar material NUDT1 295.2997307 317.6812181 272.9182434 0.859094677 -0.219110962 0.648452215 1 19.54973631 17.51853809 4521 nudix hydrolase 1 "GO:0001669,GO:0003924,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006195,GO:0006203,GO:0006281,GO:0006979,GO:0007568,GO:0008413,GO:0008584,GO:0008828,GO:0030515,GO:0031965,GO:0034656,GO:0035539,GO:0036219,GO:0042262,GO:0046061,GO:0046686,GO:0046872,GO:0047693,GO:0050072" "acrosomal vesicle|GTPase activity|protein binding|extracellular space|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|plasma membrane|purine nucleotide catabolic process|dGTP catabolic process|DNA repair|response to oxidative stress|aging|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|male gonad development|dATP pyrophosphohydrolase activity|snoRNA binding|nuclear membrane|nucleobase-containing small molecule catabolic process|8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|GTP diphosphatase activity|DNA protection|dATP catabolic process|response to cadmium ion|metal ion binding|ATP diphosphatase activity|m7G(5')pppN diphosphatase activity" NUDT12 224.1758625 204.0061496 244.3455753 1.197736322 0.260310338 0.620339297 1 2.962210949 3.700778842 83594 nudix hydrolase 12 "GO:0000210,GO:0000287,GO:0005515,GO:0005634,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006402,GO:0006734,GO:0006742,GO:0008270,GO:0019677,GO:0034356,GO:0035529,GO:0110153,GO:0110155" NAD+ diphosphatase activity|magnesium ion binding|protein binding|nucleus|cytoplasm|peroxisome|peroxisomal matrix|cytosol|mRNA catabolic process|NADH metabolic process|NADP catabolic process|zinc ion binding|NAD catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|NADH pyrophosphatase activity|RNA NAD-cap (NMN-forming) hydrolase activity|NAD-cap decapping "hsa00760,hsa04146" Nicotinate and nicotinamide metabolism|Peroxisome NUDT13 164.3595244 189.7967661 138.9222827 0.731952844 -0.450177389 0.435617953 1 4.383281641 3.346558405 25961 nudix hydrolase 13 "GO:0000210,GO:0005739,GO:0005759,GO:0006734,GO:0006742,GO:0015949,GO:0016462,GO:0035529,GO:0046872" NAD+ diphosphatase activity|mitochondrion|mitochondrial matrix|NADH metabolic process|NADP catabolic process|nucleobase-containing small molecule interconversion|pyrophosphatase activity|NADH pyrophosphatase activity|metal ion binding NUDT14 180.6933378 161.377999 200.0086766 1.239380076 0.309618681 0.582555173 1 6.036356234 7.803605415 256281 nudix hydrolase 14 "GO:0005515,GO:0005829,GO:0006753,GO:0008768,GO:0018279,GO:0019693,GO:0042802,GO:0046872,GO:0047631" protein binding|cytosol|nucleoside phosphate metabolic process|UDP-sugar diphosphatase activity|protein N-linked glycosylation via asparagine|ribose phosphate metabolic process|identical protein binding|metal ion binding|ADP-ribose diphosphatase activity NUDT15 576.8342134 468.9096574 684.7587695 1.460321319 0.546285845 0.166487984 1 10.21885539 15.56562662 55270 nudix hydrolase 15 "GO:0000278,GO:0000302,GO:0005515,GO:0005829,GO:0006195,GO:0006203,GO:0008413,GO:0017110,GO:0034656,GO:0035529,GO:0035539,GO:0036218,GO:0042262,GO:0042738,GO:0046872,GO:0047429,GO:0061136,GO:1901292" "mitotic cell cycle|response to reactive oxygen species|protein binding|cytosol|purine nucleotide catabolic process|dGTP catabolic process|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|nucleoside-diphosphatase activity|nucleobase-containing small molecule catabolic process|NADH pyrophosphatase activity|8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|dTTP diphosphatase activity|DNA protection|exogenous drug catabolic process|metal ion binding|nucleoside-triphosphate diphosphatase activity|regulation of proteasomal protein catabolic process|nucleoside phosphate catabolic process" NUDT16 551.9663084 621.1530526 482.7795641 0.777231251 -0.363584185 0.362354427 1 4.731419886 3.835815193 131870 nudix hydrolase 16 "GO:0000287,GO:0003729,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006382,GO:0006402,GO:0006508,GO:0008235,GO:0008284,GO:0016077,GO:0016311,GO:0030145,GO:0030515,GO:0031404,GO:0034656,GO:0035863,GO:0035870,GO:0042802,GO:0042803,GO:0046709,GO:0050072,GO:0050897,GO:0090068,GO:0090502,GO:0098519,GO:1901639,GO:1901640,GO:1901641,GO:1990003,GO:1990174,GO:2000233,GO:2000781" "magnesium ion binding|mRNA binding|GTP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|adenosine to inosine editing|mRNA catabolic process|proteolysis|metalloexopeptidase activity|positive regulation of cell population proliferation|sno(s)RNA catabolic process|dephosphorylation|manganese ion binding|snoRNA binding|chloride ion binding|nucleobase-containing small molecule catabolic process|dITP catabolic process|dITP diphosphatase activity|identical protein binding|protein homodimerization activity|IDP catabolic process|m7G(5')pppN diphosphatase activity|cobalt ion binding|positive regulation of cell cycle process|RNA phosphodiester bond hydrolysis, endonucleolytic|nucleotide phosphatase activity, acting on free nucleotides|XDP catabolic process|XTP binding|ITP binding|inosine-diphosphatase activity|phosphodiesterase decapping endonuclease activity|negative regulation of rRNA processing|positive regulation of double-strand break repair" "hsa00230,hsa03018" Purine metabolism|RNA degradation NUDT16L1 342.951443 308.5466144 377.3562715 1.223012193 0.290438787 0.524150752 1 2.562610287 3.269108101 84309 nudix hydrolase 16 like 1 "GO:0003723,GO:0005515,GO:0005634,GO:0006402,GO:0016077,GO:0016311,GO:0030515,GO:0042803,GO:0050072,GO:0090502,GO:0098519,GO:1990174,GO:2001033" "RNA binding|protein binding|nucleus|mRNA catabolic process|sno(s)RNA catabolic process|dephosphorylation|snoRNA binding|protein homodimerization activity|m7G(5')pppN diphosphatase activity|RNA phosphodiester bond hydrolysis, endonucleolytic|nucleotide phosphatase activity, acting on free nucleotides|phosphodiesterase decapping endonuclease activity|negative regulation of double-strand break repair via nonhomologous end joining" hsa05205 Proteoglycans in cancer NUDT17 57.49891318 57.8524902 57.14533616 0.987776602 -0.0177433 1 1 1.341586327 1.382271289 200035 nudix hydrolase 17 "GO:0005777,GO:0005829,GO:0006734,GO:0006742,GO:0019677,GO:0035529,GO:0046872" peroxisome|cytosol|NADH metabolic process|NADP catabolic process|NAD catabolic process|NADH pyrophosphatase activity|metal ion binding NUDT18 111.8463164 136.0040998 87.68853307 0.644749189 -0.633190041 0.33370537 1 3.99080409 2.683905023 79873 nudix hydrolase 18 "GO:0000287,GO:0005515,GO:0005829,GO:0034656,GO:0044715,GO:0044716,GO:0044717,GO:0046057,GO:0046067,GO:0046712" magnesium ion binding|protein binding|cytosol|nucleobase-containing small molecule catabolic process|8-oxo-dGDP phosphatase activity|8-oxo-GDP phosphatase activity|8-hydroxy-dADP phosphatase activity|dADP catabolic process|dGDP catabolic process|GDP catabolic process NUDT19 297.4335631 328.8457338 266.0213925 0.808954975 -0.305868687 0.521078888 1 4.397907662 3.710960972 390916 nudix hydrolase 19 "GO:0005575,GO:0005782,GO:0005829,GO:0006625,GO:0008150,GO:0009062,GO:0046872,GO:0047617" cellular_component|peroxisomal matrix|cytosol|protein targeting to peroxisome|biological_process|fatty acid catabolic process|metal ion binding|acyl-CoA hydrolase activity hsa04146 Peroxisome NUDT2 245.0121514 247.6492563 242.3750465 0.978702905 -0.031057113 0.959673809 1 11.84377826 12.09085673 318 nudix hydrolase 2 "GO:0004081,GO:0005515,GO:0005525,GO:0005759,GO:0006139,GO:0006167,GO:0006754,GO:0006915,GO:0008803,GO:0034599" bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity|protein binding|GTP binding|mitochondrial matrix|nucleobase-containing compound metabolic process|AMP biosynthetic process|ATP biosynthetic process|apoptotic process|bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity|cellular response to oxidative stress "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism NUDT21 3243.909616 2925.103101 3562.71613 1.217979677 0.284490061 0.371192523 1 33.7232308 42.84352014 11051 nudix hydrolase 21 "GO:0000398,GO:0003682,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005847,GO:0005849,GO:0006369,GO:0006378,GO:0006397,GO:0010608,GO:0016604,GO:0016787,GO:0030154,GO:0031124,GO:0031439,GO:0034451,GO:0035925,GO:0042382,GO:0042802,GO:0042803,GO:0042826,GO:0051262,GO:0051290,GO:0098789,GO:0110104,GO:1900365,GO:1990120,GO:2000738,GO:2000975" "mRNA splicing, via spliceosome|chromatin binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|mRNA cleavage and polyadenylation specificity factor complex|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA processing|posttranscriptional regulation of gene expression|nuclear body|hydrolase activity|cell differentiation|mRNA 3'-end processing|positive regulation of mRNA cleavage|centriolar satellite|mRNA 3'-UTR AU-rich region binding|paraspeckles|identical protein binding|protein homodimerization activity|histone deacetylase binding|protein tetramerization|protein heterotetramerization|pre-mRNA cleavage required for polyadenylation|mRNA alternative polyadenylation|positive regulation of mRNA polyadenylation|messenger ribonucleoprotein complex assembly|positive regulation of stem cell differentiation|positive regulation of pro-B cell differentiation" hsa03015 mRNA surveillance pathway NUDT22 745.7677207 769.336624 722.1988173 0.938729283 -0.091218931 0.809495623 1 27.47826936 26.90578526 84304 nudix hydrolase 22 "GO:0005515,GO:0005654,GO:0008768,GO:0046872,GO:0052751" protein binding|nucleoplasm|UDP-sugar diphosphatase activity|metal ion binding|GDP-mannose hydrolase activity NUDT3 982.9707478 853.5779694 1112.363526 1.303177409 0.382033499 0.279906747 1 4.366738678 5.935764679 11165 nudix hydrolase 3 "GO:0000287,GO:0000298,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007267,GO:0008486,GO:0015961,GO:0034431,GO:0034432,GO:0043647,GO:0050072,GO:0052840,GO:0052842,GO:0071543,GO:0071544,GO:1901907,GO:1901909,GO:1901911" magnesium ion binding|endopolyphosphatase activity|protein binding|nucleus|cytoplasm|cytosol|cell-cell signaling|diphosphoinositol-polyphosphate diphosphatase activity|diadenosine polyphosphate catabolic process|bis(5'-adenosyl)-hexaphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|inositol phosphate metabolic process|m7G(5')pppN diphosphatase activity|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol diphosphate pentakisphosphate diphosphatase activity|diphosphoinositol polyphosphate metabolic process|diphosphoinositol polyphosphate catabolic process|diadenosine pentaphosphate catabolic process|diadenosine hexaphosphate catabolic process|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process NUDT4 659.1225974 604.9137572 713.3314376 1.179228327 0.237843085 0.535543164 1 4.676652082 5.752397577 11163 nudix hydrolase 4 "GO:0000298,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008486,GO:0019722,GO:0019935,GO:0030515,GO:0034431,GO:0034432,GO:0035556,GO:0043647,GO:0046872,GO:0050072,GO:0052840,GO:0052842,GO:0071543,GO:1901907,GO:1901909,GO:1901911" endopolyphosphatase activity|protein binding|nucleus|cytoplasm|cytosol|diphosphoinositol-polyphosphate diphosphatase activity|calcium-mediated signaling|cyclic-nucleotide-mediated signaling|snoRNA binding|bis(5'-adenosyl)-hexaphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|intracellular signal transduction|inositol phosphate metabolic process|metal ion binding|m7G(5')pppN diphosphatase activity|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol diphosphate pentakisphosphate diphosphatase activity|diphosphoinositol polyphosphate metabolic process|diadenosine pentaphosphate catabolic process|diadenosine hexaphosphate catabolic process|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process NUDT4B 5.493183171 5.074779842 5.911586499 1.164895165 0.220200125 1 1 0.070571031 0.085749034 440672 nudix hydrolase 4B "GO:0000298,GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0008486,GO:0034431,GO:0034432,GO:0046872,GO:0050072,GO:0052840,GO:0052842,GO:0071543,GO:1901907,GO:1901909,GO:1901911" endopolyphosphatase activity|RNA binding|nucleus|cytoplasm|cytosol|diphosphoinositol-polyphosphate diphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|metal ion binding|m7G(5')pppN diphosphatase activity|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol diphosphate pentakisphosphate diphosphatase activity|diphosphoinositol polyphosphate metabolic process|diadenosine pentaphosphate catabolic process|diadenosine hexaphosphate catabolic process|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process NUDT5 1460.457797 1502.134833 1418.78076 0.944509593 -0.082362645 0.80601755 1 23.12396051 22.78161573 11164 nudix hydrolase 5 "GO:0000287,GO:0005515,GO:0005634,GO:0005829,GO:0006338,GO:0006753,GO:0009117,GO:0009191,GO:0016779,GO:0019144,GO:0019303,GO:0019693,GO:0030515,GO:0034656,GO:0042802,GO:0042803,GO:0044715,GO:0044716,GO:0047631,GO:0050072,GO:0070062,GO:1990966" magnesium ion binding|protein binding|nucleus|cytosol|chromatin remodeling|nucleoside phosphate metabolic process|nucleotide metabolic process|ribonucleoside diphosphate catabolic process|nucleotidyltransferase activity|ADP-sugar diphosphatase activity|D-ribose catabolic process|ribose phosphate metabolic process|snoRNA binding|nucleobase-containing small molecule catabolic process|identical protein binding|protein homodimerization activity|8-oxo-dGDP phosphatase activity|8-oxo-GDP phosphatase activity|ADP-ribose diphosphatase activity|m7G(5')pppN diphosphatase activity|extracellular exosome|ATP generation from poly-ADP-D-ribose hsa00230 Purine metabolism NUDT6 68.60404573 76.12169763 61.08639383 0.802483336 -0.317456661 0.690209025 1 2.763652648 2.313318387 11162 nudix hydrolase 6 "GO:0005634,GO:0005737,GO:0005739,GO:0008285,GO:0035529,GO:0045786,GO:0047631,GO:0051287" nucleus|cytoplasm|mitochondrion|negative regulation of cell population proliferation|NADH pyrophosphatase activity|negative regulation of cell cycle|ADP-ribose diphosphatase activity|NAD binding NUDT7 29.04773291 32.47859099 25.61687483 0.788731101 -0.342394563 0.755629422 1 1.261446362 1.037800043 283927 nudix hydrolase 7 "GO:0000287,GO:0003674,GO:0003986,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0008150,GO:0009062,GO:0009132,GO:0010945,GO:0015938,GO:0016289,GO:0030145,GO:0030515,GO:0036114,GO:0044580,GO:0046356,GO:0050072,GO:0050873,GO:1902859" magnesium ion binding|molecular_function|acetyl-CoA hydrolase activity|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|biological_process|fatty acid catabolic process|nucleoside diphosphate metabolic process|CoA pyrophosphatase activity|coenzyme A catabolic process|CoA hydrolase activity|manganese ion binding|snoRNA binding|medium-chain fatty-acyl-CoA catabolic process|butyryl-CoA catabolic process|acetyl-CoA catabolic process|m7G(5')pppN diphosphatase activity|brown fat cell differentiation|propionyl-CoA catabolic process hsa04146 Peroxisome NUDT8 29.36221581 20.29911937 38.42531225 1.892954642 0.920639843 0.359730447 1 0.934617077 1.845397168 254552 nudix hydrolase 8 "GO:0016787,GO:0046872" hydrolase activity|metal ion binding NUDT9 276.6566573 289.262451 264.0508636 0.912841825 -0.1315632 0.79207278 1 2.898718379 2.760053398 53343 nudix hydrolase 9 "GO:0005515,GO:0005739,GO:0005759,GO:0016604,GO:0019144,GO:0030054,GO:0031965,GO:0034656,GO:0046032,GO:0046709,GO:0047631,GO:0070062" protein binding|mitochondrion|mitochondrial matrix|nuclear body|ADP-sugar diphosphatase activity|cell junction|nuclear membrane|nucleobase-containing small molecule catabolic process|ADP catabolic process|IDP catabolic process|ADP-ribose diphosphatase activity|extracellular exosome hsa00230 Purine metabolism NUF2 767.2411402 688.1401466 846.3421338 1.229897918 0.298538577 0.420929963 1 16.24795842 20.84413106 83540 NUF2 component of NDC80 kinetochore complex "GO:0000775,GO:0000776,GO:0000778,GO:0003674,GO:0005515,GO:0005654,GO:0005829,GO:0007052,GO:0007059,GO:0016020,GO:0031262,GO:0044877,GO:0045132,GO:0051301,GO:0051315,GO:0051383" "chromosome, centromeric region|kinetochore|condensed nuclear chromosome kinetochore|molecular_function|protein binding|nucleoplasm|cytosol|mitotic spindle organization|chromosome segregation|membrane|Ndc80 complex|protein-containing complex binding|meiotic chromosome segregation|cell division|attachment of mitotic spindle microtubules to kinetochore|kinetochore organization" NUFIP1 212.9019832 241.5595205 184.2444459 0.762728977 -0.390757585 0.461445731 1 3.515556765 2.796921584 26747 nuclear FMR1 interacting protein 1 "GO:0000492,GO:0001650,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005726,GO:0005730,GO:0006396,GO:0008023,GO:0016363,GO:0022626,GO:0030515,GO:0030674,GO:0032991,GO:0042802,GO:0045944,GO:0046872,GO:0048786,GO:0051117,GO:0070761" box C/D snoRNP assembly|fibrillar center|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|perichromatin fibrils|nucleolus|RNA processing|transcription elongation factor complex|nuclear matrix|cytosolic ribosome|snoRNA binding|protein-macromolecule adaptor activity|protein-containing complex|identical protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding|presynaptic active zone|ATPase binding|pre-snoRNP complex NUFIP2 3341.095486 3439.685777 3242.505195 0.942674827 -0.085167892 0.789501119 1 13.89328895 13.6610131 57532 nuclear FMR1 interacting protein 2 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0010494,GO:0016020,GO:0016604,GO:0042788" RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoplasmic stress granule|membrane|nuclear body|polysomal ribosome NUMA1 6776.866169 5774.084504 7779.647833 1.347338756 0.430112628 0.188664451 1 33.74532776 47.42489553 4926 nuclear mitotic apparatus protein 1 "GO:0000132,GO:0000139,GO:0000922,GO:0001578,GO:0005198,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005794,GO:0005813,GO:0005819,GO:0005829,GO:0005876,GO:0005938,GO:0006622,GO:0006997,GO:0007059,GO:0008017,GO:0008022,GO:0015631,GO:0016328,GO:0016363,GO:0019897,GO:0019904,GO:0030425,GO:0030513,GO:0030953,GO:0031023,GO:0031116,GO:0031616,GO:0032388,GO:0032991,GO:0034067,GO:0034499,GO:0035091,GO:0035371,GO:0036449,GO:0043025,GO:0044877,GO:0045618,GO:0051010,GO:0051011,GO:0051301,GO:0051321,GO:0051798,GO:0051984,GO:0055028,GO:0055048,GO:0060236,GO:0061673,GO:0070062,GO:0070840,GO:0070861,GO:0071955,GO:0072686,GO:0090161,GO:0090235,GO:0097427,GO:0097431,GO:0097575,GO:0097718,GO:0099738,GO:1902365,GO:1902846,GO:1904778,GO:1905720,GO:1905820,GO:1905832,GO:1990023" establishment of mitotic spindle orientation|Golgi membrane|spindle pole|microtubule bundle formation|structural molecule activity|protein binding|nucleus|nucleoplasm|chromosome|Golgi apparatus|centrosome|spindle|cytosol|spindle microtubule|cell cortex|protein targeting to lysosome|nucleus organization|chromosome segregation|microtubule binding|protein C-terminus binding|tubulin binding|lateral plasma membrane|nuclear matrix|extrinsic component of plasma membrane|protein domain specific binding|dendrite|positive regulation of BMP signaling pathway|astral microtubule organization|microtubule organizing center organization|positive regulation of microtubule polymerization|spindle pole centrosome|positive regulation of intracellular transport|protein-containing complex|protein localization to Golgi apparatus|late endosome to Golgi transport|phosphatidylinositol binding|microtubule plus-end|microtubule minus-end|neuronal cell body|protein-containing complex binding|positive regulation of keratinocyte differentiation|microtubule plus-end binding|microtubule minus-end binding|cell division|meiotic cell cycle|positive regulation of hair follicle development|positive regulation of chromosome segregation|cortical microtubule|anastral spindle assembly|regulation of mitotic spindle organization|mitotic spindle astral microtubule|extracellular exosome|dynein complex binding|regulation of protein exit from endoplasmic reticulum|recycling endosome to Golgi transport|mitotic spindle|Golgi ribbon formation|regulation of metaphase plate congression|microtubule bundle|mitotic spindle pole|lateral cell cortex|disordered domain specific binding|cell cortex region|positive regulation of protein localization to spindle pole body|positive regulation of mitotic spindle elongation|positive regulation of protein localization to cell cortex|cytoplasmic microtubule bundle|positive regulation of chromosome separation|positive regulation of spindle assembly|mitotic spindle midzone NUMB 2512.591286 2537.389921 2487.792652 0.98045343 -0.028478988 0.930115209 1 34.64811219 35.43418734 8650 NUMB endocytic adaptor protein "GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005886,GO:0005905,GO:0005925,GO:0007409,GO:0008013,GO:0010008,GO:0016323,GO:0019897,GO:0021670,GO:0021849,GO:0030136,GO:0030335,GO:0034332,GO:0045177,GO:0045294,GO:0045296,GO:0050769,GO:0098978,GO:0099149,GO:1903077" protein binding|nucleus|cytoplasm|early endosome|plasma membrane|clathrin-coated pit|focal adhesion|axonogenesis|beta-catenin binding|endosome membrane|basolateral plasma membrane|extrinsic component of plasma membrane|lateral ventricle development|neuroblast division in subventricular zone|clathrin-coated vesicle|positive regulation of cell migration|adherens junction organization|apical part of cell|alpha-catenin binding|cadherin binding|positive regulation of neurogenesis|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|negative regulation of protein localization to plasma membrane hsa04330 Notch signaling pathway NUMBL 514.1511568 460.7900096 567.5123039 1.231607223 0.300542233 0.459954798 1 6.331358768 8.133642511 9253 NUMB like endocytic adaptor protein "GO:0005515,GO:0005737,GO:0007399,GO:0007409,GO:0019221,GO:0019538,GO:0021670,GO:0021849,GO:0034332,GO:0050769" protein binding|cytoplasm|nervous system development|axonogenesis|cytokine-mediated signaling pathway|protein metabolic process|lateral ventricle development|neuroblast division in subventricular zone|adherens junction organization|positive regulation of neurogenesis hsa04330 Notch signaling pathway NUP107 1919.253521 1613.77999 2224.727053 1.378581385 0.463184439 0.152190783 1 13.08134818 18.81052187 57122 nucleoporin 107 "GO:0000776,GO:0000777,GO:0000973,GO:0005515,GO:0005635,GO:0005643,GO:0005829,GO:0006110,GO:0006355,GO:0006406,GO:0006409,GO:0006606,GO:0008585,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031080,GO:0031965,GO:0034399,GO:0043657,GO:0051292,GO:0060964,GO:0072006,GO:0075733,GO:1900034" "kinetochore|condensed chromosome kinetochore|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein binding|nuclear envelope|nuclear pore|cytosol|regulation of glycolytic process|regulation of transcription, DNA-templated|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|female gonad development|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear pore outer ring|nuclear membrane|nuclear periphery|host cell|nuclear pore complex assembly|regulation of gene silencing by miRNA|nephron development|intracellular transport of virus|regulation of cellular response to heat" "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP133 1723.233161 1583.331311 1863.135012 1.176718353 0.234769053 0.472289486 1 15.39749332 18.89898504 55746 nucleoporin 133 "GO:0000777,GO:0000940,GO:0000972,GO:0005515,GO:0005635,GO:0005643,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0006999,GO:0016020,GO:0016032,GO:0016925,GO:0016973,GO:0017056,GO:0019083,GO:0021915,GO:0022008,GO:0031080,GO:0031965,GO:0043657,GO:0048339,GO:0060964,GO:0061053,GO:0072006,GO:0075733,GO:1900034" condensed chromosome kinetochore|condensed chromosome outer kinetochore|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|protein binding|nuclear envelope|nuclear pore|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear pore organization|membrane|viral process|protein sumoylation|poly(A)+ mRNA export from nucleus|structural constituent of nuclear pore|viral transcription|neural tube development|neurogenesis|nuclear pore outer ring|nuclear membrane|host cell|paraxial mesoderm development|regulation of gene silencing by miRNA|somite development|nephron development|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP153 1981.180435 2109.078502 1853.282368 0.878716636 -0.186530087 0.563417309 1 18.78273004 17.21565279 9972 nucleoporin 153 "GO:0003677,GO:0005515,GO:0005643,GO:0005654,GO:0005730,GO:0005829,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0008139,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0034399,GO:0042405,GO:0042802,GO:0043495,GO:0043657,GO:0044615,GO:0046718,GO:0046832,GO:0046872,GO:0051292,GO:0060964,GO:0075732,GO:0075733,GO:1900034" DNA binding|protein binding|nuclear pore|nucleoplasm|nucleolus|cytosol|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear localization sequence binding|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|nuclear periphery|nuclear inclusion body|identical protein binding|protein-membrane adaptor activity|host cell|nuclear pore nuclear basket|viral entry into host cell|negative regulation of RNA export from nucleus|metal ion binding|nuclear pore complex assembly|regulation of gene silencing by miRNA|viral penetration into host nucleus|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP155 2385.330357 2324.249168 2446.411546 1.052559932 0.073902382 0.818037079 1 14.06392125 15.44077837 9631 nucleoporin 155 "GO:0000972,GO:0005515,GO:0005635,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0006998,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0036228,GO:0043657,GO:0044611,GO:0060964,GO:0075733,GO:0086014,GO:1900034" transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|protein binding|nuclear envelope|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear envelope organization|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|protein localization to nuclear inner membrane|host cell|nuclear pore inner ring|regulation of gene silencing by miRNA|intracellular transport of virus|atrial cardiac muscle cell action potential|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP160 1975.621188 1998.448302 1952.794074 0.977155162 -0.03334043 0.919215769 1 16.56265036 16.88143241 23279 nucleoporin 160 "GO:0000776,GO:0005515,GO:0005635,GO:0005643,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031080,GO:0043657,GO:0060964,GO:0072006,GO:0075733,GO:1900034" kinetochore|protein binding|nuclear envelope|nuclear pore|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear pore outer ring|host cell|regulation of gene silencing by miRNA|nephron development|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP188 3550.029687 3275.26291 3824.796465 1.167783036 0.223772259 0.482004283 1 29.15811425 35.51710222 23511 nucleoporin 188 "GO:0005635,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0043657,GO:0044611,GO:0060964,GO:0075733,GO:1900034" nuclear envelope|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|host cell|nuclear pore inner ring|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP205 3954.997365 3714.738844 4195.255886 1.129354192 0.17549802 0.582007753 1 30.03486872 35.38114113 23165 nucleoporin 205 "GO:0005515,GO:0005635,GO:0005643,GO:0006110,GO:0006406,GO:0006409,GO:0006913,GO:0006999,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0034399,GO:0043657,GO:0044611,GO:0051292,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|nuclear pore|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nucleocytoplasmic transport|nuclear pore organization|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|nuclear periphery|host cell|nuclear pore inner ring|nuclear pore complex assembly|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP210 3064.772117 3274.247954 2855.296279 0.872046442 -0.197523125 0.534860226 1 15.58397782 14.17535245 23225 nucleoporin 210 "GO:0005635,GO:0005643,GO:0005789,GO:0006110,GO:0006406,GO:0006409,GO:0016020,GO:0016021,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0060964,GO:0065003,GO:0075733,GO:1900034" nuclear envelope|nuclear pore|endoplasmic reticulum membrane|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|membrane|integral component of membrane|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|regulation of gene silencing by miRNA|protein-containing complex assembly|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP214 2045.696449 1973.074403 2118.318496 1.073613085 0.10247416 0.751082285 1 12.62849209 14.14214293 8021 nucleoporin 214 "GO:0000278,GO:0005049,GO:0005515,GO:0005643,GO:0005654,GO:0005829,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0006611,GO:0008139,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0043488,GO:0043657,GO:0046822,GO:0051726,GO:0060964,GO:0075733,GO:1900034,GO:1990876" mitotic cell cycle|nuclear export signal receptor activity|protein binding|nuclear pore|nucleoplasm|cytosol|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|protein export from nucleus|nuclear localization sequence binding|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|regulation of mRNA stability|host cell|regulation of nucleocytoplasmic transport|regulation of cell cycle|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat|cytoplasmic side of nuclear pore "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP35 306.3751717 333.9205136 278.8298299 0.83501857 -0.260119812 0.582591768 1 6.575387252 5.727081971 129401 nucleoporin 35 "GO:0003697,GO:0005515,GO:0005543,GO:0005635,GO:0005652,GO:0005654,GO:0005886,GO:0006110,GO:0006355,GO:0006406,GO:0006409,GO:0006607,GO:0006999,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0042802,GO:0043657,GO:0044613,GO:0044615,GO:0060964,GO:0075733,GO:1900034,GO:1990830" "single-stranded DNA binding|protein binding|phospholipid binding|nuclear envelope|nuclear lamina|nucleoplasm|plasma membrane|regulation of glycolytic process|regulation of transcription, DNA-templated|mRNA export from nucleus|tRNA export from nucleus|NLS-bearing protein import into nucleus|nuclear pore organization|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|identical protein binding|host cell|nuclear pore central transport channel|nuclear pore nuclear basket|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat|cellular response to leukemia inhibitory factor" "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP37 840.4718709 777.4562718 903.48747 1.162107121 0.21674306 0.552429703 1 16.67037149 20.20725725 79023 nucleoporin 37 "GO:0000776,GO:0000777,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0007049,GO:0007059,GO:0016032,GO:0016925,GO:0019083,GO:0031080,GO:0043657,GO:0051301,GO:0060964,GO:0075733,GO:1900034" kinetochore|condensed chromosome kinetochore|protein binding|nucleus|nuclear envelope|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|cell cycle|chromosome segregation|viral process|protein sumoylation|viral transcription|nuclear pore outer ring|host cell|cell division|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP42 508.7740182 497.3284245 520.2196119 1.046028311 0.064921899 0.877725397 1 10.62781866 11.59587445 11097 nucleoporin 42 "GO:0003723,GO:0005049,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006611,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0046872,GO:0060964,GO:0075733,GO:1900034" RNA binding|nuclear export signal receptor activity|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein export from nucleus|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|metal ion binding|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP43 1124.1293 1073.823415 1174.435185 1.093694893 0.129210327 0.710006782 1 8.156173924 9.304618947 348995 nucleoporin 43 "GO:0000776,GO:0000777,GO:0005515,GO:0005635,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0007049,GO:0007059,GO:0016032,GO:0016607,GO:0016925,GO:0019083,GO:0031080,GO:0043657,GO:0051301,GO:0060964,GO:0075733,GO:1900034" kinetochore|condensed chromosome kinetochore|protein binding|nuclear envelope|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|cell cycle|chromosome segregation|viral process|nuclear speck|protein sumoylation|viral transcription|nuclear pore outer ring|host cell|cell division|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP50 2892.221437 3029.643566 2754.799309 0.909281653 -0.137200852 0.666860119 1 24.95377438 23.66740279 10762 nucleoporin 50 "GO:0005515,GO:0005643,GO:0005654,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear pore|nucleoplasm|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP54 963.1560959 913.4603715 1012.85182 1.10880762 0.149009077 0.675991236 1 9.357513213 10.82262425 53371 nucleoporin 54 "GO:0005515,GO:0005635,GO:0006110,GO:0006406,GO:0006409,GO:0006605,GO:0006607,GO:0006999,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0036228,GO:0042306,GO:0042802,GO:0043657,GO:0044613,GO:0044877,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein targeting|NLS-bearing protein import into nucleus|nuclear pore organization|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|protein localization to nuclear inner membrane|regulation of protein import into nucleus|identical protein binding|host cell|nuclear pore central transport channel|protein-containing complex binding|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP58 1755.113716 1843.160039 1667.067393 0.904461554 -0.144868915 0.65737141 1 18.43031662 17.38756782 9818 nucleoporin 58 "GO:0005515,GO:0005635,GO:0005643,GO:0006110,GO:0006406,GO:0006409,GO:0008139,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0042306,GO:0042802,GO:0043657,GO:0044877,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|nuclear pore|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nuclear localization sequence binding|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|regulation of protein import into nucleus|identical protein binding|host cell|protein-containing complex binding|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP62 1403.282769 1500.104921 1306.460616 0.870912826 -0.199399775 0.551605379 1 22.38509788 20.33525459 23636 nucleoporin 62 "GO:0000922,GO:0003682,GO:0005515,GO:0005543,GO:0005635,GO:0005642,GO:0005643,GO:0005654,GO:0005737,GO:0005813,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0007080,GO:0007098,GO:0007100,GO:0007166,GO:0007283,GO:0007569,GO:0008219,GO:0008285,GO:0009966,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0019894,GO:0030159,GO:0030544,GO:0031965,GO:0042059,GO:0042169,GO:0042306,GO:0043066,GO:0043069,GO:0043123,GO:0043130,GO:0043407,GO:0043657,GO:0044613,GO:0044877,GO:0045742,GO:0045840,GO:0045893,GO:0046578,GO:0046580,GO:0046601,GO:0051425,GO:0051879,GO:0060236,GO:0060964,GO:0072686,GO:0075733,GO:0090543,GO:0098534,GO:1900034,GO:1903438,GO:1904781,GO:1990904" "spindle pole|chromatin binding|protein binding|phospholipid binding|nuclear envelope|annulate lamellae|nuclear pore|nucleoplasm|cytoplasm|centrosome|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic metaphase plate congression|centrosome cycle|mitotic centrosome separation|cell surface receptor signaling pathway|spermatogenesis|cell aging|cell death|negative regulation of cell population proliferation|regulation of signal transduction|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|kinesin binding|signaling receptor complex adaptor activity|Hsp70 protein binding|nuclear membrane|negative regulation of epidermal growth factor receptor signaling pathway|SH2 domain binding|regulation of protein import into nucleus|negative regulation of apoptotic process|negative regulation of programmed cell death|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|negative regulation of MAP kinase activity|host cell|nuclear pore central transport channel|protein-containing complex binding|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|regulation of Ras protein signal transduction|negative regulation of Ras protein signal transduction|positive regulation of centriole replication|PTB domain binding|Hsp90 protein binding|regulation of mitotic spindle organization|regulation of gene silencing by miRNA|mitotic spindle|intracellular transport of virus|Flemming body|centriole assembly|regulation of cellular response to heat|positive regulation of mitotic cytokinetic process|positive regulation of protein localization to centrosome|ribonucleoprotein complex" "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP62CL 5.493183171 5.074779842 5.911586499 1.164895165 0.220200125 1 1 0.146449969 0.177947568 54830 nucleoporin 62 C-terminal like "GO:0005515,GO:0005543,GO:0006405,GO:0006606,GO:0017056,GO:0044613" protein binding|phospholipid binding|RNA export from nucleus|protein import into nucleus|structural constituent of nuclear pore|nuclear pore central transport channel NUP85 1741.42418 1479.805802 2003.042559 1.353584745 0.436785214 0.180608801 1 23.46491654 33.12992058 79902 nucleoporin 85 "GO:0000776,GO:0000777,GO:0005515,GO:0005635,GO:0005654,GO:0005819,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0030032,GO:0031080,GO:0031965,GO:0043657,GO:0045893,GO:0048246,GO:0060964,GO:0072006,GO:0075733,GO:1900034" "kinetochore|condensed chromosome kinetochore|protein binding|nuclear envelope|nucleoplasm|spindle|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|lamellipodium assembly|nuclear pore outer ring|nuclear membrane|host cell|positive regulation of transcription, DNA-templated|macrophage chemotaxis|regulation of gene silencing by miRNA|nephron development|intracellular transport of virus|regulation of cellular response to heat" "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP88 1520.764045 1549.837764 1491.690327 0.962481597 -0.055169138 0.869383664 1 20.73265062 20.81436631 4927 nucleoporin 88 "GO:0000055,GO:0000056,GO:0000278,GO:0005215,GO:0005515,GO:0005643,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0043657,GO:0060964,GO:0075733,GO:1900034" ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|mitotic cell cycle|transporter activity|protein binding|nuclear pore|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP93 1694.978935 1706.140983 1683.816888 0.986915445 -0.019001609 0.955572176 1 23.07959986 23.75878079 9688 nucleoporin 93 "GO:0005515,GO:0005635,GO:0005643,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0006998,GO:0016020,GO:0016032,GO:0016925,GO:0016973,GO:0017056,GO:0019083,GO:0031965,GO:0034399,GO:0043657,GO:0051292,GO:0060391,GO:0060395,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|nuclear pore|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear envelope organization|membrane|viral process|protein sumoylation|poly(A)+ mRNA export from nucleus|structural constituent of nuclear pore|viral transcription|nuclear membrane|nuclear periphery|host cell|nuclear pore complex assembly|positive regulation of SMAD protein signal transduction|SMAD protein signal transduction|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP98 4652.97308 4382.579871 4923.366289 1.123394538 0.167864693 0.600208281 1 28.16421897 33.00243237 4928 nucleoporin 98 and 96 precursor "GO:0000776,GO:0003713,GO:0003729,GO:0005215,GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006508,GO:0006606,GO:0006913,GO:0006999,GO:0008139,GO:0008236,GO:0016032,GO:0016604,GO:0016925,GO:0017056,GO:0019083,GO:0031080,GO:0031965,GO:0034399,GO:0042405,GO:0043231,GO:0043657,GO:0044615,GO:0045893,GO:0048026,GO:0051292,GO:0060964,GO:0075733,GO:1900034,GO:1990841,GO:1990904" "kinetochore|transcription coactivator activity|mRNA binding|transporter activity|protein binding|nuclear envelope|nuclear pore|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|proteolysis|protein import into nucleus|nucleocytoplasmic transport|nuclear pore organization|nuclear localization sequence binding|serine-type peptidase activity|viral process|nuclear body|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear pore outer ring|nuclear membrane|nuclear periphery|nuclear inclusion body|intracellular membrane-bounded organelle|host cell|nuclear pore nuclear basket|positive regulation of transcription, DNA-templated|positive regulation of mRNA splicing, via spliceosome|nuclear pore complex assembly|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat|promoter-specific chromatin binding|ribonucleoprotein complex" "hsa03013,hsa05014,hsa05164" RNA transport|Amyotrophic lateral sclerosis|Influenza A NUS1 1076.860856 1142.84042 1010.881291 0.884534073 -0.177010378 0.612099505 1 12.06856455 11.1348947 116150 NUS1 dehydrodolichyl diphosphate synthase subunit "GO:0001525,GO:0004659,GO:0005515,GO:0005789,GO:0006486,GO:0006489,GO:0016021,GO:0019408,GO:0030154,GO:0032383,GO:0035268,GO:0038084,GO:0042632,GO:0043536,GO:0045547,GO:0046872,GO:0051000,GO:1904423" angiogenesis|prenyltransferase activity|protein binding|endoplasmic reticulum membrane|protein glycosylation|dolichyl diphosphate biosynthetic process|integral component of membrane|dolichol biosynthetic process|cell differentiation|regulation of intracellular cholesterol transport|protein mannosylation|vascular endothelial growth factor signaling pathway|cholesterol homeostasis|positive regulation of blood vessel endothelial cell migration|dehydrodolichyl diphosphate synthase activity|metal ion binding|positive regulation of nitric-oxide synthase activity|dehydrodolichyl diphosphate synthase complex hsa00900 Terpenoid backbone biosynthesis NUSAP1 2448.168798 2073.555043 2822.782553 1.361325113 0.445011654 0.16361802 1 33.04538952 46.92331231 51203 nucleolar and spindle associated protein 1 "GO:0000070,GO:0000281,GO:0003677,GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0005737,GO:0007076,GO:0008017,GO:0040001,GO:0045840,GO:0072686" mitotic sister chromatid segregation|mitotic cytokinesis|DNA binding|RNA binding|protein binding|chromosome|nucleolus|cytoplasm|mitotic chromosome condensation|microtubule binding|establishment of mitotic spindle localization|positive regulation of mitotic nuclear division|mitotic spindle NUTF2 2203.315745 2072.540087 2334.091403 1.126198435 0.171461051 0.593028169 1 42.41084604 49.82046599 10204 nuclear transport factor 2 "GO:0005515,GO:0005637,GO:0005640,GO:0005654,GO:0005829,GO:0006606,GO:0006611,GO:0006913,GO:0017056,GO:0031267,GO:0031965,GO:0042307,GO:0042802,GO:0044613,GO:0051028,GO:0061608,GO:0070062,GO:0090204,GO:1904046" protein binding|nuclear inner membrane|nuclear outer membrane|nucleoplasm|cytosol|protein import into nucleus|protein export from nucleus|nucleocytoplasmic transport|structural constituent of nuclear pore|small GTPase binding|nuclear membrane|positive regulation of protein import into nucleus|identical protein binding|nuclear pore central transport channel|mRNA transport|nuclear import signal receptor activity|extracellular exosome|protein localization to nuclear pore|negative regulation of vascular endothelial growth factor production NUTM2A 44.63109266 53.79266632 35.469519 0.659374621 -0.600829734 0.501256607 1 0.426355052 0.293237542 728118 NUT family member 2A NUTM2B 3.552345889 7.104691779 0 0 #NAME? 0.089820349 1 0.109270445 0 729262 NUT family member 2B NUTM2D 54.90214015 48.71788648 61.08639383 1.253880212 0.326399528 0.705697282 1 0.375211235 0.49073588 728130 NUT family member 2D NUTM2E 78.516073 80.1815215 76.85062449 0.958458047 -0.061212811 0.952061968 1 0.649226411 0.649060555 283008 NUT family member 2E NVL 585.8688561 615.0633168 556.6743953 0.905068438 -0.143901207 0.717073727 1 8.600438207 8.119287685 4931 nuclear VCP like "GO:0000176,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005697,GO:0005730,GO:0006364,GO:0016020,GO:0016887,GO:0032092,GO:0042254,GO:0042273,GO:0051973,GO:1904749,GO:1990275" nuclear exosome (RNase complex)|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|telomerase holoenzyme complex|nucleolus|rRNA processing|membrane|ATPase activity|positive regulation of protein binding|ribosome biogenesis|ribosomal large subunit biogenesis|positive regulation of telomerase activity|regulation of protein localization to nucleolus|preribosome binding hsa03008 Ribosome biogenesis in eukaryotes NWD1 5.56741205 10.14955968 0.985264417 0.097074597 -3.364762376 0.106651607 1 0.060539323 0.00612998 284434 NACHT and WD repeat domain containing 1 "GO:0005524,GO:0005730,GO:0005829,GO:0010628,GO:0032088" ATP binding|nucleolus|cytosol|positive regulation of gene expression|negative regulation of NF-kappaB transcription factor activity NXF1 1527.185831 1517.359173 1537.01249 1.012952317 0.018566263 0.957357994 1 18.78486658 19.8478307 10482 nuclear RNA export factor 1 "GO:0000346,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0010494,GO:0016032,GO:0016607,GO:0016973,GO:0042405" transcription export complex|RNA binding|mRNA binding|protein binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|cytoplasmic stress granule|viral process|nuclear speck|poly(A)+ mRNA export from nucleus|nuclear inclusion body "hsa03008,hsa03013,hsa03015,hsa05014,hsa05164,hsa05168" Ribosome biogenesis in eukaryotes|RNA transport|mRNA surveillance pathway|Amyotrophic lateral sclerosis|Influenza A|Herpes simplex virus 1 infection NXN 1364.791392 1394.549501 1335.033284 0.957322263 -0.062923434 0.853182192 1 12.38670862 12.36886958 64359 nucleoredoxin "GO:0001701,GO:0004791,GO:0005634,GO:0005829,GO:0016055,GO:0030154,GO:0030178,GO:0031397,GO:0047134,GO:0055114,GO:0072359,GO:0098869" in utero embryonic development|thioredoxin-disulfide reductase activity|nucleus|cytosol|Wnt signaling pathway|cell differentiation|negative regulation of Wnt signaling pathway|negative regulation of protein ubiquitination|protein-disulfide reductase activity|oxidation-reduction process|circulatory system development|cellular oxidant detoxification NXNL2 9.419395061 4.059823873 14.77896625 3.640297389 1.864056314 0.210034457 1 0.075014869 0.284839458 158046 nucleoredoxin like 2 "GO:0007600,GO:0045494" sensory perception|photoreceptor cell maintenance NXPE3 1250.464348 1291.023992 1209.904704 0.937166707 -0.093622391 0.784699488 1 7.422614454 7.255873202 91775 neurexophilin and PC-esterase domain family member 3 "GO:0005515,GO:0005576" protein binding|extracellular region NXPH1 3.463271234 1.014955968 5.911586499 5.824475823 2.542128219 0.321345721 1 0.015743932 0.095650224 30010 neurexophilin 1 "GO:0005102,GO:0005576" signaling receptor binding|extracellular region NXPH3 39.21485997 20.29911937 58.13060058 2.863700613 1.517880673 0.10079223 1 0.182445215 0.544974296 11248 neurexophilin 3 "GO:0003674,GO:0005102,GO:0005576,GO:0007218" molecular_function|signaling receptor binding|extracellular region|neuropeptide signaling pathway NXPH4 236.9424842 167.4677348 306.4172335 1.829709072 0.871614275 0.088412144 1 6.278053276 11.98182488 11247 neurexophilin 4 "GO:0003674,GO:0005102,GO:0005575,GO:0005576,GO:0007218" molecular_function|signaling receptor binding|cellular_component|extracellular region|neuropeptide signaling pathway NXT1 691.910228 724.6785614 659.1418947 0.909564502 -0.136752145 0.72038016 1 34.55971057 32.78834748 29107 nuclear transport factor 2 like export factor 1 "GO:0005515,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006406,GO:0006606,GO:0006913,GO:0016607,GO:0031267,GO:0044613" protein binding|nuclear pore|nucleoplasm|cytoplasm|cytosol|mRNA export from nucleus|protein import into nucleus|nucleocytoplasmic transport|nuclear speck|small GTPase binding|nuclear pore central transport channel "hsa03008,hsa03013,hsa03015,hsa05014,hsa05164" Ribosome biogenesis in eukaryotes|RNA transport|mRNA surveillance pathway|Amyotrophic lateral sclerosis|Influenza A NXT2 336.5148111 340.0102494 333.0193728 0.979439218 -0.02997213 0.954620745 1 5.565714172 5.686097716 55916 nuclear transport factor 2 like export factor 2 "GO:0005515,GO:0005654,GO:0005829,GO:0006606,GO:0006913,GO:0044613,GO:0048471,GO:0051028" protein binding|nucleoplasm|cytosol|protein import into nucleus|nucleocytoplasmic transport|nuclear pore central transport channel|perinuclear region of cytoplasm|mRNA transport "hsa03008,hsa03013,hsa03015,hsa05014,hsa05164" Ribosome biogenesis in eukaryotes|RNA transport|mRNA surveillance pathway|Amyotrophic lateral sclerosis|Influenza A NYAP1 45.28975001 31.46363502 59.11586499 1.878863169 0.909860004 0.300956505 1 0.444621126 0.871367138 222950 neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1 "GO:0014065,GO:0048812" phosphatidylinositol 3-kinase signaling|neuron projection morphogenesis NYNRIN 643.7255517 495.2985126 792.1525909 1.599343771 0.677480072 0.078754699 1 2.828085947 4.717917657 57523 NYN domain and retroviral integrase containing "GO:0003674,GO:0003729,GO:0004521,GO:0005575,GO:0005634,GO:0008150,GO:0015074,GO:0016021,GO:0036464,GO:0090502" "molecular_function|mRNA binding|endoribonuclease activity|cellular_component|nucleus|biological_process|DNA integration|integral component of membrane|cytoplasmic ribonucleoprotein granule|RNA phosphodiester bond hydrolysis, endonucleolytic" OAF 488.6839775 639.4222601 337.9456949 0.528517251 -0.919977533 0.025847626 0.714976983 14.31674701 7.892588263 220323 out at first homolog OARD1 252.612197 228.3650929 276.859301 1.212353857 0.277810848 0.581453153 1 3.026134571 3.826780613 221443 O-acyl-ADP-ribose deacylase 1 "GO:0001883,GO:0005515,GO:0005654,GO:0005730,GO:0006974,GO:0042278,GO:0051725,GO:0061463,GO:0090734,GO:0140291,GO:0140293" purine nucleoside binding|protein binding|nucleoplasm|nucleolus|cellular response to DNA damage stimulus|purine nucleoside metabolic process|protein de-ADP-ribosylation|O-acetyl-ADP-ribose deacetylase activity|site of DNA damage|peptidyl-glutamate ADP-deribosylation|ADP-ribosylglutamate hydrolase activity OAS1 124.5926491 165.4378228 83.74747541 0.506217224 -0.982171499 0.120158311 1 2.221915168 1.173222332 4938 2'-5'-oligoadenylate synthetase 1 "GO:0001730,GO:0003725,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0006006,GO:0009615,GO:0016020,GO:0042593,GO:0045071,GO:0046872,GO:0051607,GO:0060333,GO:0060337,GO:0060700" 2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|protein binding|ATP binding|extracellular region|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|glucose metabolic process|response to virus|membrane|glucose homeostasis|negative regulation of viral genome replication|metal ion binding|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of ribonuclease activity "hsa04621,hsa05160,hsa05162,hsa05164,hsa05168,hsa05169,hsa05171" NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 OAS2 174.3457806 198.9313698 149.7601913 0.752823406 -0.409616612 0.469931647 1 2.020692357 1.586752684 4939 2'-5'-oligoadenylate synthetase 2 "GO:0001730,GO:0003725,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006139,GO:0006401,GO:0009615,GO:0009617,GO:0016020,GO:0043231,GO:0045071,GO:0046872,GO:0048471,GO:0051607,GO:0060333,GO:0060337,GO:0060700,GO:1903487" 2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|protein binding|ATP binding|nucleoplasm|cytosol|nucleobase-containing compound metabolic process|RNA catabolic process|response to virus|response to bacterium|membrane|intracellular membrane-bounded organelle|negative regulation of viral genome replication|metal ion binding|perinuclear region of cytoplasm|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of ribonuclease activity|regulation of lactation "hsa04621,hsa05160,hsa05162,hsa05164,hsa05168,hsa05169,hsa05171" NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 OAS3 1675.779641 1909.132177 1442.427106 0.755540723 -0.404418576 0.216799511 1 14.62795911 11.52809496 4940 2'-5'-oligoadenylate synthetase 3 "GO:0001730,GO:0003725,GO:0005515,GO:0005524,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0009615,GO:0016020,GO:0043231,GO:0045071,GO:0046872,GO:0051607,GO:0060333,GO:0060337,GO:0060700" 2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|protein binding|ATP binding|extracellular space|nucleoplasm|cytoplasm|cytosol|plasma membrane|nucleobase-containing compound metabolic process|response to virus|membrane|intracellular membrane-bounded organelle|negative regulation of viral genome replication|metal ion binding|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of ribonuclease activity "hsa04621,hsa05160,hsa05162,hsa05164,hsa05168,hsa05169,hsa05171" NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 OASL 287.2582712 441.5058462 133.0106962 0.301265991 -1.730890275 0.000431376 0.049549754 10.00927197 3.145346733 8638 2'-5'-oligoadenylate synthetase like "GO:0001730,GO:0003677,GO:0003723,GO:0003725,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0009615,GO:0016020,GO:0045071,GO:0046966,GO:0051607,GO:0060333,GO:0060337,GO:0060700" 2'-5'-oligoadenylate synthetase activity|DNA binding|RNA binding|double-stranded RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|response to virus|membrane|negative regulation of viral genome replication|thyroid hormone receptor binding|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of ribonuclease activity hsa05165 Human papillomavirus infection OAT 2449.887941 2595.242411 2304.53347 0.887983897 -0.17139458 0.5917137 1 30.37667498 28.13592868 4942 ornithine aminotransferase "GO:0004587,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0007601,GO:0008652,GO:0010121,GO:0019544,GO:0030170,GO:0042802,GO:0050155,GO:0055129" ornithine-oxo-acid transaminase activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|visual perception|cellular amino acid biosynthetic process|arginine catabolic process to proline via ornithine|arginine catabolic process to glutamate|pyridoxal phosphate binding|identical protein binding|ornithine(lysine) transaminase activity|L-proline biosynthetic process hsa00330 Arginine and proline metabolism OAZ1 7822.52344 7511.689122 8133.357759 1.082760166 0.114713718 0.728320931 1 322.1342543 363.8187755 4946 ornithine decarboxylase antizyme 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006521,GO:0006596,GO:0008073,GO:0043086,GO:0045732,GO:0090316,GO:1902268" protein binding|nucleus|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|polyamine biosynthetic process|ornithine decarboxylase inhibitor activity|negative regulation of catalytic activity|positive regulation of protein catabolic process|positive regulation of intracellular protein transport|negative regulation of polyamine transmembrane transport OAZ2 1442.57062 1356.99613 1528.14511 1.126123411 0.17136494 0.607832489 1 35.53622894 41.74200021 4947 ornithine decarboxylase antizyme 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006521,GO:0006595,GO:0006596,GO:0008073,GO:0043086,GO:0045732,GO:0090316,GO:1902268" protein binding|nucleus|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|polyamine metabolic process|polyamine biosynthetic process|ornithine decarboxylase inhibitor activity|negative regulation of catalytic activity|positive regulation of protein catabolic process|positive regulation of intracellular protein transport|negative regulation of polyamine transmembrane transport OAZ3 11.52353588 13.19442759 9.852644165 0.74672767 -0.421345905 0.803618457 1 0.570180214 0.444109759 51686 ornithine decarboxylase antizyme 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0006596,GO:0007283,GO:0008073,GO:0043086,GO:0045732,GO:0072562,GO:1902268" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|polyamine biosynthetic process|spermatogenesis|ornithine decarboxylase inhibitor activity|negative regulation of catalytic activity|positive regulation of protein catabolic process|blood microparticle|negative regulation of polyamine transmembrane transport OBI1 452.290061 441.5058462 463.0742758 1.048851968 0.068811075 0.874544623 1 6.277572592 6.867866913 79596 ORC ubiquitin ligase 1 "GO:0000785,GO:0003682,GO:0004842,GO:0005515,GO:0006275,GO:0006513,GO:0046872,GO:0051865" chromatin|chromatin binding|ubiquitin-protein transferase activity|protein binding|regulation of DNA replication|protein monoubiquitination|metal ion binding|protein autoubiquitination OBSCN 292.2548628 311.5914823 272.9182434 0.875884801 -0.191186961 0.692717278 1 0.549592859 0.502115931 84033 "obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF" "GO:0005085,GO:0005515,GO:0005516,GO:0005524,GO:0005546,GO:0005547,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0006468,GO:0007186,GO:0007275,GO:0008307,GO:0010314,GO:0016604,GO:0030016,GO:0030018,GO:0030506,GO:0031430,GO:0031432,GO:0032266,GO:0036309,GO:0042383,GO:0043065,GO:0043325,GO:0045214,GO:0046872,GO:0050790,GO:0050839,GO:0051056,GO:0070273,GO:0098609,GO:0106310,GO:0106311" "guanyl-nucleotide exchange factor activity|protein binding|calmodulin binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|protein phosphorylation|G protein-coupled receptor signaling pathway|multicellular organism development|structural constituent of muscle|phosphatidylinositol-5-phosphate binding|nuclear body|myofibril|Z disc|ankyrin binding|M band|titin binding|phosphatidylinositol-3-phosphate binding|protein localization to M-band|sarcolemma|positive regulation of apoptotic process|phosphatidylinositol-3,4-bisphosphate binding|sarcomere organization|metal ion binding|regulation of catalytic activity|cell adhesion molecule binding|regulation of small GTPase mediated signal transduction|phosphatidylinositol-4-phosphate binding|cell-cell adhesion|protein serine kinase activity|protein threonine kinase activity" OBSL1 1091.969151 1131.675905 1052.262397 0.929826634 -0.104966344 0.764243693 1 7.725487567 7.49279429 23363 obscurin like cytoskeletal adaptor 1 "GO:0000226,GO:0005515,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0007010,GO:0007030,GO:0007088,GO:0007156,GO:0007416,GO:0008093,GO:0010842,GO:0014704,GO:0030018,GO:0031430,GO:0034067,GO:0043687,GO:0045202,GO:0048471,GO:0050775,GO:0055003,GO:1990393" microtubule cytoskeleton organization|protein binding|cytoplasm|Golgi apparatus|centrosome|cytosol|cytoskeleton organization|Golgi organization|regulation of mitotic nuclear division|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|cytoskeletal anchor activity|retina layer formation|intercalated disc|Z disc|M band|protein localization to Golgi apparatus|post-translational protein modification|synapse|perinuclear region of cytoplasm|positive regulation of dendrite morphogenesis|cardiac myofibril assembly|3M complex OCEL1 261.1354023 238.5146526 283.756152 1.189680168 0.250573774 0.615834575 1 10.52258338 13.05775536 79629 occludin/ELL domain containing 1 OCIAD1 1565.029437 1511.269437 1618.789436 1.071145487 0.099154445 0.765021112 1 42.38121016 47.35193658 54940 OCIA domain containing 1 "GO:0005515,GO:0005764,GO:0005768,GO:0005794,GO:0016020,GO:0019731,GO:0046427,GO:1902037,GO:2000736" protein binding|lysosome|endosome|Golgi apparatus|membrane|antibacterial humoral response|positive regulation of receptor signaling pathway via JAK-STAT|negative regulation of hematopoietic stem cell differentiation|regulation of stem cell differentiation OCIAD2 1011.037176 1021.045704 1001.028647 0.980395533 -0.028564184 0.938185617 1 45.68229937 46.71595259 132299 OCIA domain containing 2 "GO:0005764,GO:0005768,GO:0005794,GO:0019731,GO:0046427,GO:1902037" lysosome|endosome|Golgi apparatus|antibacterial humoral response|positive regulation of receptor signaling pathway via JAK-STAT|negative regulation of hematopoietic stem cell differentiation OCLN 228.8025474 217.2005772 240.4045176 1.106831854 0.14643607 0.783030269 1 1.74030106 2.009194422 100506658 occludin "GO:0001933,GO:0005515,GO:0005765,GO:0005886,GO:0005911,GO:0005923,GO:0010592,GO:0010628,GO:0010629,GO:0010827,GO:0016021,GO:0016324,GO:0016327,GO:0016328,GO:0019904,GO:0030054,GO:0030139,GO:0031116,GO:0031252,GO:0031410,GO:0032991,GO:0035633,GO:0045216,GO:0046326,GO:0065003,GO:0070160,GO:0070673,GO:0070830,GO:0071356,GO:0090303,GO:1902463,GO:1905605,GO:2000810" negative regulation of protein phosphorylation|protein binding|lysosomal membrane|plasma membrane|cell-cell junction|bicellular tight junction|positive regulation of lamellipodium assembly|positive regulation of gene expression|negative regulation of gene expression|regulation of glucose transmembrane transport|integral component of membrane|apical plasma membrane|apicolateral plasma membrane|lateral plasma membrane|protein domain specific binding|cell junction|endocytic vesicle|positive regulation of microtubule polymerization|cell leading edge|cytoplasmic vesicle|protein-containing complex|maintenance of blood-brain barrier|cell-cell junction organization|positive regulation of glucose import|protein-containing complex assembly|tight junction|response to interleukin-18|bicellular tight junction assembly|cellular response to tumor necrosis factor|positive regulation of wound healing|protein localization to cell leading edge|positive regulation of blood-brain barrier permeability|regulation of bicellular tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C OCRL 2351.372632 2090.809295 2611.935968 1.249246392 0.321058052 0.315199751 1 20.45829112 26.65835751 4952 OCRL inositol polyphosphate-5-phosphatase "GO:0001750,GO:0004439,GO:0004445,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005769,GO:0005795,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0005905,GO:0006629,GO:0006661,GO:0007165,GO:0016020,GO:0030136,GO:0030670,GO:0031267,GO:0031901,GO:0043087,GO:0043547,GO:0043647,GO:0046855,GO:0046856,GO:0051056,GO:0052658,GO:0052659,GO:0052745,GO:0060271,GO:0061024" "photoreceptor outer segment|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|GTPase activator activity|protein binding|nucleus|cytoplasm|lysosome|early endosome|Golgi stack|Golgi-associated vesicle|trans-Golgi network|cytosol|plasma membrane|clathrin-coated pit|lipid metabolic process|phosphatidylinositol biosynthetic process|signal transduction|membrane|clathrin-coated vesicle|phagocytic vesicle membrane|small GTPase binding|early endosome membrane|regulation of GTPase activity|positive regulation of GTPase activity|inositol phosphate metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|regulation of small GTPase mediated signal transduction|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol phosphate phosphatase activity|cilium assembly|membrane organization" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system ODAD3 15.43490199 11.16451565 19.70528833 1.764992674 0.819662195 0.515777845 1 0.251084961 0.462252786 115948 outer dynein arm docking complex subunit 3 "GO:0003341,GO:0005515,GO:0005814,GO:0005929,GO:0005930,GO:0007368,GO:0036064,GO:0036158,GO:1902017" cilium movement|protein binding|centriole|cilium|axoneme|determination of left/right symmetry|ciliary basal body|outer dynein arm assembly|regulation of cilium assembly ODAD4 9.56785282 14.20938356 4.926322083 0.346694989 -1.528261108 0.297156206 1 0.228752431 0.08272356 83538 outer dynein arm docking complex subunit 4 "GO:0003341,GO:0005515,GO:0005576,GO:0005737,GO:0005930,GO:0007420,GO:0007507,GO:0030324,GO:0036158,GO:0060287,GO:0090660,GO:0097729,GO:0120197,GO:0120228,GO:0120229" cilium movement|protein binding|extracellular region|cytoplasm|axoneme|brain development|heart development|lung development|outer dynein arm assembly|epithelial cilium movement involved in determination of left/right asymmetry|cerebrospinal fluid circulation|9+2 motile cilium|mucociliary clearance|outer dynein arm docking complex|protein localization to motile cilium ODAPH 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.053527184 0.018066527 152816 odontogenesis associated phosphoprotein "GO:0005515,GO:0005576,GO:0070169,GO:0070175" protein binding|extracellular region|positive regulation of biomineral tissue development|positive regulation of enamel mineralization ODC1 3759.159367 5481.777185 2036.541549 0.371511187 -1.428522441 1.06E-05 0.002653656 92.08380626 35.6837993 4953 ornithine decarboxylase 1 "GO:0004586,GO:0005515,GO:0005575,GO:0005737,GO:0005829,GO:0006521,GO:0006595,GO:0009615,GO:0033387,GO:0042176,GO:0042803,GO:0048471" ornithine decarboxylase activity|protein binding|cellular_component|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|polyamine metabolic process|response to virus|putrescine biosynthetic process from ornithine|regulation of protein catabolic process|protein homodimerization activity|perinuclear region of cytoplasm "hsa00330,hsa00480" Arginine and proline metabolism|Glutathione metabolism ODF2 1167.752117 1227.081766 1108.422469 0.9032996 -0.146723524 0.670546849 1 13.18637016 12.42433093 4957 outer dense fiber of sperm tails 2 "GO:0000086,GO:0000922,GO:0001520,GO:0005198,GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0007275,GO:0007286,GO:0008104,GO:0010389,GO:0010457,GO:0036126,GO:0044782,GO:0097539,GO:0097711,GO:0120103" G2/M transition of mitotic cell cycle|spindle pole|outer dense fiber|structural molecule activity|protein binding|nucleus|centrosome|centriole|cytosol|microtubule|multicellular organism development|spermatid development|protein localization|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|sperm flagellum|cilium organization|ciliary transition fiber|ciliary basal body-plasma membrane docking|centriolar subdistal appendage ODF2L 587.0404346 526.7621476 647.3187217 1.228863396 0.297324551 0.450164486 1 6.046836915 7.750822542 57489 outer dense fiber of sperm tails 2 like "GO:0005737,GO:0005813,GO:0005814,GO:0030030,GO:0034451,GO:0036064,GO:1902018" cytoplasm|centrosome|centriole|cell projection organization|centriolar satellite|ciliary basal body|negative regulation of cilium assembly ODF3B 49.49803164 49.73284245 49.26322083 0.990557113 -0.013687936 1 1 2.673877944 2.762721004 440836 outer dense fiber of sperm tails 3B "GO:0005515,GO:0005856" protein binding|cytoskeleton ODR4 414.597635 424.2515948 404.9436752 0.954489459 -0.06719883 0.8809004 1 5.381128627 5.357478533 54953 odr-4 GPCR localization factor homolog "GO:0008104,GO:0016021" protein localization|integral component of membrane OFD1 412.4219869 376.5486643 448.2953095 1.190537511 0.251613077 0.560504633 1 4.595388304 5.706649876 8481 OFD1 centriole and centriolar satellite protein "GO:0000086,GO:0000278,GO:0005515,GO:0005576,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0007099,GO:0010389,GO:0015630,GO:0016020,GO:0031514,GO:0034451,GO:0036064,GO:0042802,GO:0043014,GO:0043015,GO:0060271,GO:0060287,GO:0090307,GO:0097711" G2/M transition of mitotic cell cycle|mitotic cell cycle|protein binding|extracellular region|nucleus|centrosome|centriole|cytosol|cilium|centriole replication|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|membrane|motile cilium|centriolar satellite|ciliary basal body|identical protein binding|alpha-tubulin binding|gamma-tubulin binding|cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry|mitotic spindle assembly|ciliary basal body-plasma membrane docking OGA 8083.631134 8826.057101 7341.205168 0.831764975 -0.265752159 0.42193262 1 75.07703321 65.13638634 10724 O-GlcNAcase "GO:0004415,GO:0005634,GO:0005829,GO:0006044,GO:0006493,GO:0006516,GO:0006517,GO:0009100,GO:0016020,GO:0016032,GO:0016231,GO:0102166,GO:0102167,GO:0102571" hyalurononglucosaminidase activity|nucleus|cytosol|N-acetylglucosamine metabolic process|protein O-linked glycosylation|glycoprotein catabolic process|protein deglycosylation|glycoprotein metabolic process|membrane|viral process|beta-N-acetylglucosaminidase activity|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity hsa04931 Insulin resistance OGDH 2266.496631 2384.13157 2148.861692 0.901318417 -0.149891225 0.640051519 1 26.86270374 25.2547979 4967 oxoglutarate dehydrogenase "GO:0004591,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0006091,GO:0006096,GO:0006099,GO:0006103,GO:0006104,GO:0006554,GO:0030976,GO:0031966,GO:0045252,GO:0046872,GO:0106077" oxoglutarate dehydrogenase (succinyl-transferring) activity|protein binding|nucleus|mitochondrion|mitochondrial matrix|generation of precursor metabolites and energy|glycolytic process|tricarboxylic acid cycle|2-oxoglutarate metabolic process|succinyl-CoA metabolic process|lysine catabolic process|thiamine pyrophosphate binding|mitochondrial membrane|oxoglutarate dehydrogenase complex|metal ion binding|histone succinylation hsa00020 Citrate cycle (TCA cycle) OGDHL 78.38246101 71.04691779 85.71800424 1.206498563 0.270826198 0.723751632 1 0.912341721 1.148154346 55753 oxoglutarate dehydrogenase L "GO:0004591,GO:0005515,GO:0005739,GO:0005759,GO:0006096,GO:0006099,GO:0030976,GO:0045252,GO:0046872" oxoglutarate dehydrogenase (succinyl-transferring) activity|protein binding|mitochondrion|mitochondrial matrix|glycolytic process|tricarboxylic acid cycle|thiamine pyrophosphate binding|oxoglutarate dehydrogenase complex|metal ion binding hsa00020 Citrate cycle (TCA cycle) OGFOD1 948.6646426 865.757441 1031.571844 1.191525242 0.252809514 0.47786399 1 8.567323208 10.64790893 55239 2-oxoglutarate and iron dependent oxygenase domain containing 1 "GO:0005506,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006449,GO:0008283,GO:0010494,GO:0018126,GO:0019511,GO:0031418,GO:0031543,GO:0031544,GO:0034063,GO:0055114" iron ion binding|protein binding|nucleoplasm|cytoplasm|cytosol|regulation of translational termination|cell population proliferation|cytoplasmic stress granule|protein hydroxylation|peptidyl-proline hydroxylation|L-ascorbic acid binding|peptidyl-proline dioxygenase activity|peptidyl-proline 3-dioxygenase activity|stress granule assembly|oxidation-reduction process OGFOD2 229.4436374 227.3501369 231.5371379 1.018416532 0.026327743 0.968554475 1 4.480343343 4.759405047 79676 2-oxoglutarate and iron dependent oxygenase domain containing 2 "GO:0005506,GO:0016705,GO:0031418,GO:0051213,GO:0055114" "iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|L-ascorbic acid binding|dioxygenase activity|oxidation-reduction process" OGFOD3 682.7662218 638.4073041 727.1251394 1.13896745 0.187726518 0.622827475 1 7.24631954 8.608841734 79701 2-oxoglutarate and iron dependent oxygenase domain containing 3 "GO:0005506,GO:0016020,GO:0016021,GO:0016705,GO:0031418,GO:0051213,GO:0055114" "iron ion binding|membrane|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|L-ascorbic acid binding|dioxygenase activity|oxidation-reduction process" OGFR 1956.230382 1986.26883 1926.191934 0.969753895 -0.04430943 0.892282073 1 41.74170502 42.22285998 11054 opioid growth factor receptor "GO:0001558,GO:0004985,GO:0005515,GO:0005575,GO:0005634,GO:0005737,GO:0016020,GO:0038003" regulation of cell growth|opioid receptor activity|protein binding|cellular_component|nucleus|cytoplasm|membrane|opioid receptor signaling pathway OGFRL1 3486.824307 3265.11335 3708.535264 1.135805979 0.183716411 0.563825022 1 14.70185567 17.41775731 79627 opioid growth factor receptor like 1 "GO:0004985,GO:0016020,GO:0038003" opioid receptor activity|membrane|opioid receptor signaling pathway OGG1 471.7132796 422.2216828 521.2048764 1.234434179 0.303849913 0.464949213 1 4.445746097 5.724380894 4968 8-oxoguanine DNA glycosylase "GO:0002526,GO:0003684,GO:0004519,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006284,GO:0006285,GO:0006355,GO:0006974,GO:0006979,GO:0007568,GO:0008017,GO:0008534,GO:0009314,GO:0009416,GO:0016363,GO:0016607,GO:0032355,GO:0032357,GO:0032991,GO:0033683,GO:0034039,GO:0042493,GO:0043066,GO:0045007,GO:0045008,GO:0045471,GO:0051593,GO:0071276,GO:0140078,GO:1901291" "acute inflammatory response|damaged DNA binding|endonuclease activity|protein binding|nucleus|nucleoplasm|mitochondrion|base-excision repair|base-excision repair, AP site formation|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|response to oxidative stress|aging|microtubule binding|oxidized purine nucleobase lesion DNA N-glycosylase activity|response to radiation|response to light stimulus|nuclear matrix|nuclear speck|response to estradiol|oxidized purine DNA binding|protein-containing complex|nucleotide-excision repair, DNA incision|8-oxo-7,8-dihydroguanine DNA N-glycosylase activity|response to drug|negative regulation of apoptotic process|depurination|depyrimidination|response to ethanol|response to folic acid|cellular response to cadmium ion|class I DNA-(apurinic or apyrimidinic site) endonuclease activity|negative regulation of double-strand break repair via single-strand annealing" hsa03410 Base excision repair OGT 5437.715653 4819.010938 6056.420369 1.256776639 0.329728269 0.306780269 1 45.30646066 59.39284997 8473 O-linked N-acetylglucosamine (GlcNAc) transferase "GO:0000123,GO:0005515,GO:0005547,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006110,GO:0006111,GO:0006357,GO:0006493,GO:0006915,GO:0007165,GO:0007584,GO:0008375,GO:0016032,GO:0016262,GO:0016485,GO:0016579,GO:0017122,GO:0018215,GO:0031397,GO:0031966,GO:0032435,GO:0032868,GO:0032922,GO:0032991,GO:0035020,GO:0042995,GO:0043981,GO:0043982,GO:0043984,GO:0045862,GO:0045944,GO:0046626,GO:0048015,GO:0061087,GO:0080182,GO:0097363,GO:0120162" "histone acetyltransferase complex|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of glycolytic process|regulation of gluconeogenesis|regulation of transcription by RNA polymerase II|protein O-linked glycosylation|apoptotic process|signal transduction|response to nutrient|acetylglucosaminyltransferase activity|viral process|protein N-acetylglucosaminyltransferase activity|protein processing|protein deubiquitination|protein N-acetylglucosaminyltransferase complex|protein phosphopantetheinylation|negative regulation of protein ubiquitination|mitochondrial membrane|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|response to insulin|circadian regulation of gene expression|protein-containing complex|regulation of Rac protein signal transduction|cell projection|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|positive regulation of proteolysis|positive regulation of transcription by RNA polymerase II|regulation of insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of histone H3-K27 methylation|histone H3-K4 trimethylation|protein O-GlcNAc transferase activity|positive regulation of cold-induced thermogenesis" "hsa00514,hsa04931" Other types of O-glycan biosynthesis|Insulin resistance other OIP5 139.507949 141.0788796 137.9370183 0.977729754 -0.032492337 0.970292335 1 5.949331853 6.067404595 11339 Opa interacting protein 5 "GO:0000775,GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0007049,GO:0007059,GO:0007154,GO:0010369,GO:0015030,GO:0016607,GO:0034080,GO:0042802,GO:0043231,GO:0046872,GO:0051301" "chromosome, centromeric region|chromatin|protein binding|nucleus|nucleoplasm|cell cycle|chromosome segregation|cell communication|chromocenter|Cajal body|nuclear speck|CENP-A containing nucleosome assembly|identical protein binding|intracellular membrane-bounded organelle|metal ion binding|cell division" OLA1 1995.798819 2064.42044 1927.177199 0.933519724 -0.09924759 0.759139052 1 24.59553339 23.94945712 29789 Obg like ATPase 1 "GO:0002576,GO:0005515,GO:0005524,GO:0005525,GO:0005576,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0016020,GO:0016887,GO:0031093,GO:0043022,GO:0043023,GO:0045296,GO:0046034,GO:0046872,GO:0070062" platelet degranulation|protein binding|ATP binding|GTP binding|extracellular region|nucleolus|cytoplasm|centrosome|cytosol|membrane|ATPase activity|platelet alpha granule lumen|ribosome binding|ribosomal large subunit binding|cadherin binding|ATP metabolic process|metal ion binding|extracellular exosome OLAH 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.104585838 0.05294981 55301 oleoyl-ACP hydrolase "GO:0004320,GO:0005829,GO:0008610,GO:0016295,GO:0016296,GO:0047381,GO:0051792" oleoyl-[acyl-carrier-protein] hydrolase activity|cytosol|lipid biosynthetic process|myristoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|dodecanoyl-[acyl-carrier-protein] hydrolase activity|medium-chain fatty acid biosynthetic process hsa00061 Fatty acid biosynthesis OLFM2 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.107991469 0 93145 olfactomedin 2 "GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0009306,GO:0032281,GO:0045202,GO:0051152,GO:1905174" protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|protein secretion|AMPA glutamate receptor complex|synapse|positive regulation of smooth muscle cell differentiation|regulation of vascular associated smooth muscle cell dedifferentiation OLFML2A 189.8670356 249.6791682 130.054903 0.520888082 -0.940954667 0.087057044 1 1.868405593 1.015153016 169611 olfactomedin like 2A "GO:0030198,GO:0031012,GO:0042802,GO:0050840" extracellular matrix organization|extracellular matrix|identical protein binding|extracellular matrix binding OLFML2B 44.82408775 66.98709391 22.66108158 0.338290262 -1.563666445 0.078539588 1 0.346862283 0.12239467 25903 olfactomedin like 2B GO:0005576 extracellular region OLFML3 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.06766644 0.068516451 56944 olfactomedin like 3 "GO:0007275,GO:1903561" multicellular organism development|extracellular vesicle OMA1 155.670294 201.9762377 109.3643502 0.54147137 -0.885043035 0.131257103 1 5.496713547 3.104520511 115209 OMA1 zinc metallopeptidase "GO:0002024,GO:0004222,GO:0005743,GO:0006006,GO:0006515,GO:0006629,GO:0008289,GO:0010637,GO:0016021,GO:0016540,GO:0031638,GO:0031966,GO:0033108,GO:0034982,GO:0042981,GO:0043065,GO:0046872,GO:0097009,GO:0120162,GO:0140467,GO:0140468,GO:1903850" diet induced thermogenesis|metalloendopeptidase activity|mitochondrial inner membrane|glucose metabolic process|protein quality control for misfolded or incompletely synthesized proteins|lipid metabolic process|lipid binding|negative regulation of mitochondrial fusion|integral component of membrane|protein autoprocessing|zymogen activation|mitochondrial membrane|mitochondrial respiratory chain complex assembly|mitochondrial protein processing|regulation of apoptotic process|positive regulation of apoptotic process|metal ion binding|energy homeostasis|positive regulation of cold-induced thermogenesis|integrated stress response signaling|HRI-mediated signaling|regulation of cristae formation hsa05017 Spinocerebellar ataxia OMP 7.971189988 6.08973581 9.852644165 1.617909951 0.694131313 0.702268135 1 0.626877308 1.057919994 4975 olfactory marker protein "GO:0005634,GO:0005829,GO:0007165,GO:0007268,GO:0007608,GO:0022008,GO:0030424,GO:0043025,GO:0045202" nucleus|cytosol|signal transduction|chemical synaptic transmission|sensory perception of smell|neurogenesis|axon|neuronal cell body|synapse ONECUT2 91.086978 63.94222601 118.23173 1.849039944 0.886776391 0.205939965 1 0.197069809 0.38008639 9480 one cut homeobox 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001889,GO:0001952,GO:0002064,GO:0005634,GO:0005654,GO:0006357,GO:0009887,GO:0015629,GO:0030335,GO:0030512,GO:0031018,GO:0045165,GO:0045944,GO:0048935,GO:0060271,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|regulation of cell-matrix adhesion|epithelial cell development|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|animal organ morphogenesis|actin cytoskeleton|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|endocrine pancreas development|cell fate commitment|positive regulation of transcription by RNA polymerase II|peripheral nervous system neuron development|cilium assembly|sequence-specific double-stranded DNA binding" OPA1 1785.914734 1793.427196 1778.402272 0.991622228 -0.012137484 0.97211954 1 14.00196711 14.48275674 4976 OPA1 mitochondrial dynamin like GTPase "GO:0000002,GO:0000266,GO:0000287,GO:0001843,GO:0003374,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005829,GO:0006915,GO:0007005,GO:0007007,GO:0007601,GO:0008017,GO:0008053,GO:0010636,GO:0014042,GO:0014850,GO:0016020,GO:0016021,GO:0019896,GO:0019900,GO:0030061,GO:0030425,GO:0031314,GO:0031667,GO:0031966,GO:0036444,GO:0043066,GO:0044877,GO:0046039,GO:0046628,GO:0048285,GO:0048312,GO:0051259,GO:0051602,GO:0060041,GO:0061003,GO:0061025,GO:0070300,GO:0070584,GO:0071333,GO:0071456,GO:0090102,GO:0090201,GO:0090398,GO:0097749,GO:1900006,GO:1901612,GO:1902236,GO:1904115,GO:1904643,GO:1905232" mitochondrial genome maintenance|mitochondrial fission|magnesium ion binding|neural tube closure|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|protein binding|GTP binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|apoptotic process|mitochondrion organization|inner mitochondrial membrane organization|visual perception|microtubule binding|mitochondrial fusion|positive regulation of mitochondrial fusion|positive regulation of neuron maturation|response to muscle activity|membrane|integral component of membrane|axonal transport of mitochondrion|kinase binding|mitochondrial crista|dendrite|extrinsic component of mitochondrial inner membrane|response to nutrient levels|mitochondrial membrane|calcium import into the mitochondrion|negative regulation of apoptotic process|protein-containing complex binding|GTP metabolic process|positive regulation of insulin receptor signaling pathway|organelle fission|intracellular distribution of mitochondria|protein complex oligomerization|response to electrical stimulus|retina development in camera-type eye|positive regulation of dendritic spine morphogenesis|membrane fusion|phosphatidic acid binding|mitochondrion morphogenesis|cellular response to glucose stimulus|cellular response to hypoxia|cochlea development|negative regulation of release of cytochrome c from mitochondria|cellular senescence|membrane tubulation|positive regulation of dendrite development|cardiolipin binding|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|axon cytoplasm|response to curcumin|cellular response to L-glutamate hsa05017 Spinocerebellar ataxia OPA3 895.7639606 987.5521572 803.9757639 0.814109673 -0.296704934 0.409503801 1 5.07004895 4.305375123 80207 outer mitochondrial membrane lipid metabolism regulator OPA3 "GO:0005739,GO:0007601,GO:0019216,GO:0050896" mitochondrion|visual perception|regulation of lipid metabolic process|response to stimulus OPHN1 250.4459514 248.6642123 252.2276906 1.014330483 0.02052778 0.976177208 1 1.190018437 1.259067742 4983 oligophrenin 1 "GO:0003779,GO:0005096,GO:0005543,GO:0005737,GO:0005829,GO:0006930,GO:0007165,GO:0007399,GO:0007411,GO:0015629,GO:0021707,GO:0021895,GO:0030036,GO:0030100,GO:0030182,GO:0031175,GO:0034329,GO:0035023,GO:0035255,GO:0043195,GO:0043197,GO:0043547,GO:0045198,GO:0048488,GO:0048667,GO:0051056,GO:0051966,GO:0098880,GO:0098978,GO:0099149,GO:1901799" "actin binding|GTPase activator activity|phospholipid binding|cytoplasm|cytosol|substrate-dependent cell migration, cell extension|signal transduction|nervous system development|axon guidance|actin cytoskeleton|cerebellar granule cell differentiation|cerebral cortex neuron differentiation|actin cytoskeleton organization|regulation of endocytosis|neuron differentiation|neuron projection development|cell junction assembly|regulation of Rho protein signal transduction|ionotropic glutamate receptor binding|terminal bouton|dendritic spine|positive regulation of GTPase activity|establishment of epithelial cell apical/basal polarity|synaptic vesicle endocytosis|cell morphogenesis involved in neuron differentiation|regulation of small GTPase mediated signal transduction|regulation of synaptic transmission, glutamatergic|maintenance of postsynaptic specialization structure|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|negative regulation of proteasomal protein catabolic process" OPLAH 899.3947408 764.2618442 1034.527637 1.353629839 0.436833277 0.224051257 1 8.904340063 12.57238254 26873 "5-oxoprolinase, ATP-hydrolysing" "GO:0005515,GO:0005524,GO:0005829,GO:0006749,GO:0006750,GO:0017168,GO:0042802" protein binding|ATP binding|cytosol|glutathione metabolic process|glutathione biosynthetic process|5-oxoprolinase (ATP-hydrolyzing) activity|identical protein binding hsa00480 Glutathione metabolism OPN3 136.3618822 94.39090506 178.3328594 1.889301297 0.917852795 0.134445447 1 0.485287418 0.956348506 23596 opsin 3 "GO:0001750,GO:0004930,GO:0005502,GO:0005503,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007602,GO:0008020,GO:0009583,GO:0009584,GO:0009637,GO:0009881,GO:0016021,GO:0018298,GO:0030216,GO:0042752,GO:0043066,GO:0046326,GO:0048022,GO:0048023,GO:0071482,GO:0071492,GO:1901857" photoreceptor outer segment|G protein-coupled receptor activity|11-cis retinal binding|all-trans retinal binding|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|phototransduction|G protein-coupled photoreceptor activity|detection of light stimulus|detection of visible light|response to blue light|photoreceptor activity|integral component of membrane|protein-chromophore linkage|keratinocyte differentiation|regulation of circadian rhythm|negative regulation of apoptotic process|positive regulation of glucose import|negative regulation of melanin biosynthetic process|positive regulation of melanin biosynthetic process|cellular response to light stimulus|cellular response to UV-A|positive regulation of cellular respiration OPRL1 63.0217879 64.95718198 61.08639383 0.940410159 -0.088637971 0.931198009 1 0.832873952 0.816982063 4987 opioid related nociceptin receptor 1 "GO:0001626,GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0007218,GO:0007600,GO:0007610,GO:0019233,GO:0031410,GO:0038003,GO:0042277,GO:0042923,GO:0043005,GO:0051482" nociceptin receptor activity|G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|sensory perception|behavior|sensory perception of pain|cytoplasmic vesicle|opioid receptor signaling pathway|peptide binding|neuropeptide binding|neuron projection|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway hsa04080 Neuroactive ligand-receptor interaction OPTN 3138.181489 2634.825694 3641.537284 1.382079009 0.466840092 0.142602516 1 36.77173499 53.01062471 10133 optineurin "GO:0000086,GO:0000139,GO:0001920,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005776,GO:0005794,GO:0005802,GO:0005829,GO:0006914,GO:0007030,GO:0007165,GO:0008022,GO:0008219,GO:0010508,GO:0016032,GO:0030674,GO:0031267,GO:0031593,GO:0034067,GO:0034620,GO:0042802,GO:0043001,GO:0043122,GO:0043124,GO:0045087,GO:0046872,GO:0048471,GO:0050829,GO:0055038,GO:0061734,GO:0070530,GO:0090161,GO:1904417" G2/M transition of mitotic cell cycle|Golgi membrane|negative regulation of receptor recycling|protein binding|nucleus|nucleoplasm|cytoplasm|autophagosome|Golgi apparatus|trans-Golgi network|cytosol|autophagy|Golgi organization|signal transduction|protein C-terminus binding|cell death|positive regulation of autophagy|viral process|protein-macromolecule adaptor activity|small GTPase binding|polyubiquitin modification-dependent protein binding|protein localization to Golgi apparatus|cellular response to unfolded protein|identical protein binding|Golgi to plasma membrane protein transport|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|metal ion binding|perinuclear region of cytoplasm|defense response to Gram-negative bacterium|recycling endosome membrane|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|K63-linked polyubiquitin modification-dependent protein binding|Golgi ribbon formation|positive regulation of xenophagy "hsa04137,hsa05014,hsa05022" Mitophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases OR1J2 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.025987836 0.078942867 26740 olfactory receptor family 1 subfamily J member 2 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR2A1 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.032493008 0.021934119 346528 olfactory receptor family 2 subfamily A member 1 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR2A7 14.52386645 16.23929549 12.80843742 0.788731101 -0.342394563 0.827932218 1 0.398866648 0.328150159 401427 olfactory receptor family 2 subfamily A member 7 "GO:0004930,GO:0004984,GO:0005549,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|odorant binding|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR2AG2 11.46415277 9.134603715 13.79370183 1.510049287 0.594595639 0.696434627 1 0.109525439 0.17251309 338755 olfactory receptor family 2 subfamily AG member 2 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR2B6 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.272844688 0 26212 olfactory receptor family 2 subfamily B member 6 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR51B5 5.015396738 6.08973581 3.941057666 0.64716398 -0.627796782 0.826813936 1 0.212120795 0.143190272 282763 olfactory receptor family 51 subfamily B member 5 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0007608,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|sensory perception of smell|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR6A2 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.035904963 0.012118664 8590 olfactory receptor family 6 subfamily A member 2 "GO:0004930,GO:0004984,GO:0005886,GO:0007165,GO:0007186,GO:0007608,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|sensory perception of smell|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction ORAI1 719.3343282 713.5140458 725.1546106 1.016314416 0.023346796 0.954387596 1 24.10738445 25.55607237 84876 ORAI calcium release-activated calcium modulator 1 "GO:0002115,GO:0002250,GO:0005262,GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0005887,GO:0015279,GO:0016020,GO:0016323,GO:0034704,GO:0042802,GO:0044853,GO:0045121,GO:0045762,GO:0051924,GO:0051928,GO:0061180,GO:0070509,GO:0070588" store-operated calcium entry|adaptive immune response|calcium channel activity|protein binding|calmodulin binding|cytosol|plasma membrane|integral component of plasma membrane|store-operated calcium channel activity|membrane|basolateral plasma membrane|calcium channel complex|identical protein binding|plasma membrane raft|membrane raft|positive regulation of adenylate cyclase activity|regulation of calcium ion transport|positive regulation of calcium ion transport|mammary gland epithelium development|calcium ion import|calcium ion transmembrane transport "hsa04020,hsa04024,hsa04611,hsa04924,hsa04925,hsa04927,hsa04934,hsa05340" Calcium signaling pathway|cAMP signaling pathway|Platelet activation|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Primary immunodeficiency ORAI2 1919.054837 2038.031584 1800.078089 0.88324347 -0.179116917 0.580010685 1 9.583947076 8.829594763 80228 ORAI calcium release-activated calcium modulator 2 "GO:0002115,GO:0005515,GO:0015279,GO:0016020,GO:0016021,GO:0030426,GO:0070588" store-operated calcium entry|protein binding|store-operated calcium channel activity|membrane|integral component of membrane|growth cone|calcium ion transmembrane transport hsa04020 Calcium signaling pathway ORAI3 500.8864597 564.3155184 437.4574009 0.77520002 -0.367359488 0.368957618 1 12.96759992 10.48550394 93129 ORAI calcium release-activated calcium modulator 3 "GO:0002115,GO:0005515,GO:0005886,GO:0015279,GO:0016020,GO:0016021,GO:0070588" store-operated calcium entry|protein binding|plasma membrane|store-operated calcium channel activity|membrane|integral component of membrane|calcium ion transmembrane transport hsa04020 Calcium signaling pathway ORC1 573.8851012 570.4052542 577.3649481 1.012201314 0.017496253 0.969522669 1 9.084595553 9.591541803 4998 origin recognition complex subunit 1 "GO:0000082,GO:0000083,GO:0000781,GO:0000808,GO:0003677,GO:0003682,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005664,GO:0005829,GO:0006260,GO:0006270,GO:0016887,GO:0033314,GO:0046872" "G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|chromosome, telomeric region|origin recognition complex|DNA binding|chromatin binding|DNA replication origin binding|protein binding|ATP binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|cytosol|DNA replication|DNA replication initiation|ATPase activity|mitotic DNA replication checkpoint|metal ion binding" hsa04110 Cell cycle other ORC2 671.7177507 657.6914675 685.7440339 1.042653079 0.060259212 0.877998453 1 7.443520141 8.095321998 4999 origin recognition complex subunit 2 "GO:0000082,GO:0000122,GO:0000781,GO:0000792,GO:0000808,GO:0000939,GO:0003688,GO:0005515,GO:0005634,GO:0005654,GO:0005664,GO:0005813,GO:0006260,GO:0006270,GO:0016020" "G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|heterochromatin|origin recognition complex|condensed chromosome inner kinetochore|DNA replication origin binding|protein binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|centrosome|DNA replication|DNA replication initiation|membrane" hsa04110 Cell cycle ORC3 585.6191995 564.3155184 606.9228806 1.07550273 0.105011187 0.792766946 1 8.170551807 9.165978514 23595 origin recognition complex subunit 3 "GO:0000082,GO:0000781,GO:0000785,GO:0000808,GO:0003688,GO:0005515,GO:0005654,GO:0005656,GO:0005664,GO:0006260,GO:0006267,GO:0006270,GO:0006275,GO:0016604,GO:0031261,GO:0061351" "G1/S transition of mitotic cell cycle|chromosome, telomeric region|chromatin|origin recognition complex|DNA replication origin binding|protein binding|nucleoplasm|nuclear pre-replicative complex|nuclear origin of replication recognition complex|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA replication initiation|regulation of DNA replication|nuclear body|DNA replication preinitiation complex|neural precursor cell proliferation" hsa04110 Cell cycle ORC4 457.1245868 468.9096574 445.3395163 0.949734153 -0.07440436 0.863508835 1 3.403356253 3.37151734 5000 origin recognition complex subunit 4 "GO:0000082,GO:0000166,GO:0000781,GO:0000808,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005664,GO:0005730,GO:0005829,GO:0006260,GO:0006270" "G1/S transition of mitotic cell cycle|nucleotide binding|chromosome, telomeric region|origin recognition complex|DNA replication origin binding|protein binding|ATP binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|nucleolus|cytosol|DNA replication|DNA replication initiation" hsa04110 Cell cycle ORC5 533.1599314 581.5697699 484.7500929 0.8335201 -0.262711105 0.51492009 1 7.453050908 6.47986704 5001 origin recognition complex subunit 5 "GO:0000082,GO:0000166,GO:0000781,GO:0000785,GO:0000808,GO:0003674,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005664,GO:0005829,GO:0006260,GO:0006270,GO:0006275" "G1/S transition of mitotic cell cycle|nucleotide binding|chromosome, telomeric region|chromatin|origin recognition complex|molecular_function|DNA replication origin binding|protein binding|ATP binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|cytosol|DNA replication|DNA replication initiation|regulation of DNA replication" hsa04110 Cell cycle ORC6 657.0926854 600.8539333 713.3314376 1.187196086 0.24755824 0.519171862 1 17.25120864 21.36278715 23594 origin recognition complex subunit 6 "GO:0000082,GO:0000808,GO:0001650,GO:0003677,GO:0005515,GO:0005654,GO:0005664,GO:0006260,GO:0006270,GO:0016020,GO:0051782" G1/S transition of mitotic cell cycle|origin recognition complex|fibrillar center|DNA binding|protein binding|nucleoplasm|nuclear origin of replication recognition complex|DNA replication|DNA replication initiation|membrane|negative regulation of cell division hsa04110 Cell cycle ORMDL1 805.8985416 771.366536 840.4305473 1.089534622 0.123712042 0.738165284 1 6.710235972 7.625964126 94101 ORMDL sphingolipid biosynthesis regulator 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006672,GO:0016021,GO:0035339,GO:0090156,GO:1900060" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|ceramide metabolic process|integral component of membrane|SPOTS complex|cellular sphingolipid homeostasis|negative regulation of ceramide biosynthetic process ORMDL2 1153.703316 1243.321061 1064.08557 0.855841345 -0.224584718 0.514666059 1 31.18862089 27.8423164 29095 ORMDL sphingolipid biosynthesis regulator 2 "GO:0005515,GO:0005783,GO:0006672,GO:0016021,GO:0035339,GO:0090156,GO:1900060" protein binding|endoplasmic reticulum|ceramide metabolic process|integral component of membrane|SPOTS complex|cellular sphingolipid homeostasis|negative regulation of ceramide biosynthetic process ORMDL3 1194.821403 989.5820692 1400.060736 1.414800025 0.500598149 0.143873532 1 13.46918591 19.87706856 94103 ORMDL sphingolipid biosynthesis regulator 3 "GO:0002903,GO:0005515,GO:0005783,GO:0005886,GO:0006672,GO:0006686,GO:0006940,GO:0010508,GO:0016021,GO:0030667,GO:0035339,GO:0035579,GO:0042552,GO:0043312,GO:0061744,GO:0090156,GO:1900060,GO:1900182,GO:1904221" negative regulation of B cell apoptotic process|protein binding|endoplasmic reticulum|plasma membrane|ceramide metabolic process|sphingomyelin biosynthetic process|regulation of smooth muscle contraction|positive regulation of autophagy|integral component of membrane|secretory granule membrane|SPOTS complex|specific granule membrane|myelination|neutrophil degranulation|motor behavior|cellular sphingolipid homeostasis|negative regulation of ceramide biosynthetic process|positive regulation of protein localization to nucleus|negative regulation of serine C-palmitoyltransferase activity OS9 4548.143127 5164.095967 3932.190286 0.76144795 -0.393182673 0.219318966 1 99.06941019 78.68568479 10956 OS9 endoplasmic reticulum lectin "GO:0000836,GO:0002020,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0006511,GO:0006605,GO:0006621,GO:0016567,GO:0030246,GO:0030433,GO:0030970,GO:0034976,GO:0044322,GO:0055085,GO:1904153,GO:1904380" "Hrd1p ubiquitin ligase complex|protease binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|ubiquitin-dependent protein catabolic process|protein targeting|protein retention in ER lumen|protein ubiquitination|carbohydrate binding|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|response to endoplasmic reticulum stress|endoplasmic reticulum quality control compartment|transmembrane transport|negative regulation of retrograde protein transport, ER to cytosol|endoplasmic reticulum mannose trimming" hsa04141 Protein processing in endoplasmic reticulum OSBP 2306.043295 2730.231555 1881.855036 0.689265726 -0.536867816 0.093640931 1 29.33940093 21.09375296 5007 oxysterol binding protein "GO:0000139,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006699,GO:0008142,GO:0015248,GO:0015918,GO:0016020,GO:0019904,GO:0030054,GO:0032367,GO:0032934,GO:0043231,GO:0048471,GO:0070273,GO:0097038,GO:0120009,GO:0120015" Golgi membrane|protein binding|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|bile acid biosynthetic process|oxysterol binding|sterol transporter activity|sterol transport|membrane|protein domain specific binding|cell junction|intracellular cholesterol transport|sterol binding|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|phosphatidylinositol-4-phosphate binding|perinuclear endoplasmic reticulum|intermembrane lipid transfer|sterol transfer activity OSBP2 192.3626098 218.2155332 166.5096864 0.763051484 -0.390147695 0.477179362 1 2.146823415 1.708701081 23762 oxysterol binding protein 2 "GO:0005515,GO:0005829,GO:0005886,GO:0007286,GO:0015248,GO:0015485,GO:0015918,GO:0016020,GO:0032934,GO:0043231,GO:0097038,GO:0097440" protein binding|cytosol|plasma membrane|spermatid development|sterol transporter activity|cholesterol binding|sterol transport|membrane|sterol binding|intracellular membrane-bounded organelle|perinuclear endoplasmic reticulum|apical dendrite OSBPL10 1302.56039 1518.374129 1086.746651 0.715730485 -0.482511666 0.153518097 1 11.79271479 8.803983909 114884 oxysterol binding protein like 10 "GO:0001786,GO:0005515,GO:0005548,GO:0005829,GO:0005856,GO:0015248,GO:0015485,GO:0015914,GO:0015918,GO:0016020,GO:0032934,GO:0036150,GO:0043231" phosphatidylserine binding|protein binding|phospholipid transporter activity|cytosol|cytoskeleton|sterol transporter activity|cholesterol binding|phospholipid transport|sterol transport|membrane|sterol binding|phosphatidylserine acyl-chain remodeling|intracellular membrane-bounded organelle OSBPL11 387.9833716 389.7430919 386.2236513 0.990969845 -0.013086938 0.982743147 1 4.292977962 4.437465892 114885 oxysterol binding protein like 11 "GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0010890,GO:0015248,GO:0015918,GO:0016020,GO:0031902,GO:0032934,GO:0043231,GO:0045444" protein binding|nucleoplasm|Golgi apparatus|cytosol|positive regulation of sequestering of triglyceride|sterol transporter activity|sterol transport|membrane|late endosome membrane|sterol binding|intracellular membrane-bounded organelle|fat cell differentiation OSBPL1A 589.0824707 565.3304744 612.8344671 1.084028714 0.116402972 0.770036081 1 4.907780967 5.549347073 114876 oxysterol binding protein like 1A "GO:0005515,GO:0005543,GO:0005768,GO:0005770,GO:0005829,GO:0006699,GO:0008203,GO:0015248,GO:0015485,GO:0015918,GO:0016020,GO:0016192,GO:0019886,GO:0032934,GO:0043231,GO:0044232,GO:0070062" protein binding|phospholipid binding|endosome|late endosome|cytosol|bile acid biosynthetic process|cholesterol metabolic process|sterol transporter activity|cholesterol binding|sterol transport|membrane|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|sterol binding|intracellular membrane-bounded organelle|organelle membrane contact site|extracellular exosome OSBPL2 1599.231621 1491.985274 1706.477969 1.14376328 0.193788494 0.556431364 1 18.73172799 22.34755021 9885 oxysterol binding protein like 2 "GO:0005515,GO:0005546,GO:0005811,GO:0005829,GO:0006699,GO:0007009,GO:0008526,GO:0015248,GO:0015485,GO:0015914,GO:0016020,GO:0030301,GO:0031234,GO:0032367,GO:0032934,GO:0043231,GO:0051289,GO:0120009,GO:0120020" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|lipid droplet|cytosol|bile acid biosynthetic process|plasma membrane organization|phosphatidylinositol transfer activity|sterol transporter activity|cholesterol binding|phospholipid transport|membrane|cholesterol transport|extrinsic component of cytoplasmic side of plasma membrane|intracellular cholesterol transport|sterol binding|intracellular membrane-bounded organelle|protein homotetramerization|intermembrane lipid transfer|cholesterol transfer activity" OSBPL3 1218.097842 1132.690861 1303.504823 1.150803691 0.202641753 0.553401172 1 7.948842483 9.541596936 26031 oxysterol binding protein like 3 "GO:0005515,GO:0005789,GO:0005829,GO:0005886,GO:0006699,GO:0015248,GO:0015485,GO:0015918,GO:0016020,GO:0031965,GO:0032433,GO:0032934,GO:0043231,GO:0097038" protein binding|endoplasmic reticulum membrane|cytosol|plasma membrane|bile acid biosynthetic process|sterol transporter activity|cholesterol binding|sterol transport|membrane|nuclear membrane|filopodium tip|sterol binding|intracellular membrane-bounded organelle|perinuclear endoplasmic reticulum OSBPL5 427.6342023 372.4888404 482.7795641 1.29609135 0.374167405 0.380143781 1 3.432541067 4.640526786 114879 oxysterol binding protein like 5 "GO:0001786,GO:0005548,GO:0005789,GO:0005829,GO:0006893,GO:0008142,GO:0008203,GO:0015248,GO:0015485,GO:0015914,GO:0016020,GO:0016021,GO:0030301,GO:0032934,GO:0036150,GO:0043231,GO:0070273,GO:0120009,GO:0140268,GO:0140343" phosphatidylserine binding|phospholipid transporter activity|endoplasmic reticulum membrane|cytosol|Golgi to plasma membrane transport|oxysterol binding|cholesterol metabolic process|sterol transporter activity|cholesterol binding|phospholipid transport|membrane|integral component of membrane|cholesterol transport|sterol binding|phosphatidylserine acyl-chain remodeling|intracellular membrane-bounded organelle|phosphatidylinositol-4-phosphate binding|intermembrane lipid transfer|endoplasmic reticulum-plasma membrane contact site|phosphatidylserine transfer activity hsa04979 Cholesterol metabolism OSBPL6 243.4600259 242.5744764 244.3455753 1.007301258 0.010495221 0.992697702 1 1.090110158 1.145369707 114880 oxysterol binding protein like 6 "GO:0005515,GO:0005789,GO:0005829,GO:0005886,GO:0006699,GO:0015248,GO:0015485,GO:0015918,GO:0016020,GO:0031901,GO:0031965,GO:0032374,GO:0032934,GO:0043231,GO:0097038" protein binding|endoplasmic reticulum membrane|cytosol|plasma membrane|bile acid biosynthetic process|sterol transporter activity|cholesterol binding|sterol transport|membrane|early endosome membrane|nuclear membrane|regulation of cholesterol transport|sterol binding|intracellular membrane-bounded organelle|perinuclear endoplasmic reticulum OSBPL7 131.910625 126.869496 136.9517539 1.079469519 0.110322507 0.869685433 1 1.581465027 1.780680102 114881 oxysterol binding protein like 7 "GO:0005515,GO:0005654,GO:0005776,GO:0005789,GO:0005829,GO:0005886,GO:0006699,GO:0010506,GO:0015248,GO:0015485,GO:0015918,GO:0016020,GO:0032934,GO:0043231,GO:0071397,GO:0097038,GO:1901800" protein binding|nucleoplasm|autophagosome|endoplasmic reticulum membrane|cytosol|plasma membrane|bile acid biosynthetic process|regulation of autophagy|sterol transporter activity|cholesterol binding|sterol transport|membrane|sterol binding|intracellular membrane-bounded organelle|cellular response to cholesterol|perinuclear endoplasmic reticulum|positive regulation of proteasomal protein catabolic process OSBPL8 2120.339012 1956.835107 2283.842918 1.16711056 0.222941234 0.487710102 1 12.10095175 14.73151654 114882 oxysterol binding protein like 8 "GO:0001786,GO:0005515,GO:0005548,GO:0005789,GO:0005829,GO:0010891,GO:0015248,GO:0015485,GO:0015914,GO:0015918,GO:0016020,GO:0016021,GO:0030336,GO:0031965,GO:0032148,GO:0032934,GO:0036150,GO:0043231,GO:0045444,GO:0046326,GO:0046628,GO:0051897,GO:0070273,GO:0090204,GO:0120009,GO:0140343" phosphatidylserine binding|protein binding|phospholipid transporter activity|endoplasmic reticulum membrane|cytosol|negative regulation of sequestering of triglyceride|sterol transporter activity|cholesterol binding|phospholipid transport|sterol transport|membrane|integral component of membrane|negative regulation of cell migration|nuclear membrane|activation of protein kinase B activity|sterol binding|phosphatidylserine acyl-chain remodeling|intracellular membrane-bounded organelle|fat cell differentiation|positive regulation of glucose import|positive regulation of insulin receptor signaling pathway|positive regulation of protein kinase B signaling|phosphatidylinositol-4-phosphate binding|protein localization to nuclear pore|intermembrane lipid transfer|phosphatidylserine transfer activity OSBPL9 2180.583156 2033.971761 2327.194552 1.144162666 0.194292175 0.544834194 1 27.63237507 32.97781805 114883 oxysterol binding protein like 9 "GO:0005515,GO:0005794,GO:0005829,GO:0006699,GO:0015248,GO:0015918,GO:0016020,GO:0031902,GO:0032934,GO:0043231" protein binding|Golgi apparatus|cytosol|bile acid biosynthetic process|sterol transporter activity|sterol transport|membrane|late endosome membrane|sterol binding|intracellular membrane-bounded organelle OSCAR 1435.799216 1466.611374 1404.987058 0.957981837 -0.061929792 0.854433566 1 35.90076956 35.87376532 126014 osteoclast associated Ig-like receptor "GO:0005576,GO:0005886,GO:0016021,GO:0030316,GO:0035580,GO:0038064,GO:0038065,GO:0043312,GO:0050776,GO:0070062,GO:1904724" extracellular region|plasma membrane|integral component of membrane|osteoclast differentiation|specific granule lumen|collagen receptor activity|collagen-activated signaling pathway|neutrophil degranulation|regulation of immune response|extracellular exosome|tertiary granule lumen hsa04380 Osteoclast differentiation OSCP1 94.98077673 94.39090506 95.57064841 1.012498485 0.01791975 0.996773023 1 2.752197093 2.906630616 127700 organic solute carrier partner 1 "GO:0005737,GO:0009925,GO:0022857,GO:1990961" cytoplasm|basal plasma membrane|transmembrane transporter activity|xenobiotic detoxification by transmembrane export across the plasma membrane OSER1 1096.431294 965.2231259 1227.639463 1.271871166 0.346952541 0.317538445 1 7.766944109 10.30408023 51526 oxidative stress responsive serine rich 1 GO:0070301 cellular response to hydrogen peroxide OSGEP 465.8974487 529.8070155 401.987882 0.758743977 -0.398314936 0.338830191 1 13.57938071 10.74709655 55644 O-sialoglycoprotein endopeptidase "GO:0000408,GO:0002949,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0016607,GO:0046872,GO:0061711" EKC/KEOPS complex|tRNA threonylcarbamoyladenosine modification|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|nuclear speck|metal ion binding|N(6)-L-threonylcarbamoyladenine synthase activity OSGEPL1 183.782743 170.5126027 197.0528833 1.155649965 0.208704486 0.712691324 1 2.315244449 2.790866687 64172 O-sialoglycoprotein endopeptidase like 1 "GO:0000408,GO:0002949,GO:0005739,GO:0046872,GO:0061711" EKC/KEOPS complex|tRNA threonylcarbamoyladenosine modification|mitochondrion|metal ion binding|N(6)-L-threonylcarbamoyladenine synthase activity OSGIN1 52.36475023 43.64310664 61.08639383 1.399680237 0.485097274 0.570890433 1 1.150036102 1.67902141 29948 oxidative stress induced growth inhibitor 1 "GO:0005515,GO:0005575,GO:0007165,GO:0007275,GO:0008083,GO:0030154,GO:0030308,GO:0030334,GO:0042127,GO:0042981,GO:0043065" protein binding|cellular_component|signal transduction|multicellular organism development|growth factor activity|cell differentiation|negative regulation of cell growth|regulation of cell migration|regulation of cell population proliferation|regulation of apoptotic process|positive regulation of apoptotic process OSGIN2 811.0881283 654.6465996 967.529657 1.477941927 0.563589583 0.124300709 1 2.579194151 3.976100331 734 oxidative stress induced growth inhibitor family member 2 "GO:0003674,GO:0005575,GO:0007165,GO:0008083,GO:0030308,GO:0051321" molecular_function|cellular_component|signal transduction|growth factor activity|negative regulation of cell growth|meiotic cell cycle OSMR 3469.64676 3572.645009 3366.648511 0.94234062 -0.085679462 0.788267974 1 28.26774975 27.78529931 9180 oncostatin M receptor "GO:0002675,GO:0004896,GO:0004923,GO:0004924,GO:0005127,GO:0005515,GO:0005886,GO:0005900,GO:0008284,GO:0009897,GO:0016324,GO:0019221,GO:0019838,GO:0019955,GO:0034097,GO:0038165,GO:0043235,GO:0048861" positive regulation of acute inflammatory response|cytokine receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|ciliary neurotrophic factor receptor binding|protein binding|plasma membrane|oncostatin-M receptor complex|positive regulation of cell population proliferation|external side of plasma membrane|apical plasma membrane|cytokine-mediated signaling pathway|growth factor binding|cytokine binding|response to cytokine|oncostatin-M-mediated signaling pathway|receptor complex|leukemia inhibitory factor signaling pathway "hsa04060,hsa04151,hsa04630" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway OSR1 73.80031338 60.8973581 86.70326866 1.423760757 0.509706742 0.501676676 1 1.012220661 1.503239385 130497 odd-skipped related transcription factor 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001655,GO:0001657,GO:0001823,GO:0002062,GO:0005634,GO:0005829,GO:0006357,GO:0007507,GO:0008406,GO:0009790,GO:0010628,GO:0019898,GO:0030154,GO:0030501,GO:0030857,GO:0035115,GO:0035116,GO:0036023,GO:0042474,GO:0042476,GO:0042733,GO:0043066,GO:0045944,GO:0046872,GO:0048389,GO:0048793,GO:0048863,GO:0050679,GO:0060021,GO:0060272,GO:0071300,GO:0072075,GO:0072111,GO:0072133,GO:0072143,GO:0072162,GO:0072166,GO:0072168,GO:0072169,GO:0072180,GO:0072183,GO:0072184,GO:0072190,GO:0072207,GO:0072208,GO:0072234,GO:0072239,GO:0072259,GO:0072268,GO:0072498,GO:0090094,GO:1905408,GO:1990837,GO:2000543,GO:2000650" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|urogenital system development|ureteric bud development|mesonephros development|chondrocyte differentiation|nucleus|cytosol|regulation of transcription by RNA polymerase II|heart development|gonad development|embryo development|positive regulation of gene expression|extrinsic component of membrane|cell differentiation|positive regulation of bone mineralization|negative regulation of epithelial cell differentiation|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic skeletal limb joint morphogenesis|middle ear morphogenesis|odontogenesis|embryonic digit morphogenesis|negative regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|metal ion binding|intermediate mesoderm development|pronephros development|stem cell differentiation|positive regulation of epithelial cell proliferation|roof of mouth development|embryonic skeletal joint morphogenesis|cellular response to retinoic acid|metanephric mesenchyme development|cell proliferation involved in kidney development|metanephric mesenchyme morphogenesis|mesangial cell development|metanephric mesenchymal cell differentiation|posterior mesonephric tubule development|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|mesonephric duct morphogenesis|negative regulation of nephron tubule epithelial cell differentiation|renal vesicle progenitor cell differentiation|ureter urothelium development|metanephric epithelium development|metanephric smooth muscle tissue development|metanephric nephron tubule development|metanephric glomerulus vasculature development|metanephric interstitial fibroblast development|pattern specification involved in metanephros development|embryonic skeletal joint development|metanephric cap mesenchymal cell proliferation involved in metanephros development|negative regulation of creatine transmembrane transporter activity|sequence-specific double-stranded DNA binding|positive regulation of gastrulation|negative regulation of sodium ion transmembrane transporter activity" OSR2 47.0348706 49.73284245 44.33689874 0.891501401 -0.165691029 0.870538997 1 1.196008083 1.112172301 116039 odd-skipped related transciption factor 2 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0001228,GO:0001655,GO:0001656,GO:0001823,GO:0002062,GO:0005515,GO:0005634,GO:0006357,GO:0008284,GO:0009790,GO:0009792,GO:0010628,GO:0030154,GO:0030501,GO:0033687,GO:0035115,GO:0035116,GO:0036023,GO:0042474,GO:0042476,GO:0042733,GO:0043565,GO:0045893,GO:0045944,GO:0046872,GO:0048704,GO:0050679,GO:0060021,GO:0060272,GO:0060322,GO:0060349,GO:0061029,GO:0072498,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|urogenital system development|metanephros development|mesonephros development|chondrocyte differentiation|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|embryo development|embryo development ending in birth or egg hatching|positive regulation of gene expression|cell differentiation|positive regulation of bone mineralization|osteoblast proliferation|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic skeletal limb joint morphogenesis|middle ear morphogenesis|odontogenesis|embryonic digit morphogenesis|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|embryonic skeletal system morphogenesis|positive regulation of epithelial cell proliferation|roof of mouth development|embryonic skeletal joint morphogenesis|head development|bone morphogenesis|eyelid development in camera-type eye|embryonic skeletal joint development|sequence-specific double-stranded DNA binding" zf-C2H2 OST4 1941.495953 1989.313698 1893.678209 0.951925385 -0.071079599 0.827062841 1 227.94507 226.3336055 100128731 "oligosaccharyltransferase complex subunit 4, non-catalytic" "GO:0005515,GO:0008250,GO:0016021,GO:0018279" protein binding|oligosaccharyltransferase complex|integral component of membrane|protein N-linked glycosylation via asparagine OSTC 1185.77439 1179.378835 1192.169944 1.010845632 0.015562698 0.966456955 1 52.58043786 55.44022279 58505 oligosaccharyltransferase complex non-catalytic subunit "GO:0004579,GO:0005515,GO:0008250,GO:0016021,GO:0018279" dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|oligosaccharyltransferase complex|integral component of membrane|protein N-linked glycosylation via asparagine OSTF1 430.0649501 403.9524754 456.1774249 1.129284885 0.175409481 0.682977766 1 15.12104052 17.81152572 26578 osteoclast stimulating factor 1 "GO:0001503,GO:0005515,GO:0005576,GO:0005622,GO:0007165,GO:0017124,GO:0034774,GO:0043312,GO:1904813" ossification|protein binding|extracellular region|intracellular anatomical structure|signal transduction|SH3 domain binding|secretory granule lumen|neutrophil degranulation|ficolin-1-rich granule lumen OSTM1 606.4918609 711.4841338 501.499588 0.70486405 -0.504583069 0.195876423 1 8.059530622 5.925582381 28962 osteoclastogenesis associated transmembrane protein 1 "GO:0005765,GO:0005829,GO:0016021,GO:0030316,GO:0034220" lysosomal membrane|cytosol|integral component of membrane|osteoclast differentiation|ion transmembrane transport OTP 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.019080898 0.057961764 23440 orthopedia homeobox "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0001650,GO:0002052,GO:0003677,GO:0005515,GO:0005654,GO:0016604,GO:0021879,GO:0021979,GO:0021985,GO:0030182" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|fibrillar center|positive regulation of neuroblast proliferation|DNA binding|protein binding|nucleoplasm|nuclear body|forebrain neuron differentiation|hypothalamus cell differentiation|neurohypophysis development|neuron differentiation" OTUB1 1984.360399 1922.326604 2046.394193 1.064540328 0.090230604 0.780685243 1 57.23636739 63.55505674 55611 "OTU deubiquitinase, ubiquitin aldehyde binding 1" "GO:0002250,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0016579,GO:0018215,GO:0019784,GO:0031625,GO:0043130,GO:0070062,GO:0071108,GO:1901315,GO:2000780" adaptive immune response|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|protein deubiquitination|protein phosphopantetheinylation|NEDD8-specific protease activity|ubiquitin protein ligase binding|ubiquitin binding|extracellular exosome|protein K48-linked deubiquitination|negative regulation of histone H2A K63-linked ubiquitination|negative regulation of double-strand break repair OTUB2 582.0208324 756.1421964 407.8994685 0.539448096 -0.890443939 0.024336308 0.691114326 9.791852401 5.509731725 78990 "OTU deubiquitinase, ubiquitin aldehyde binding 2" "GO:0004843,GO:0005515,GO:0005634,GO:0016579,GO:0018215,GO:0019784,GO:0035871,GO:0043130,GO:0070536,GO:0071108,GO:1901315,GO:2000780" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|protein deubiquitination|protein phosphopantetheinylation|NEDD8-specific protease activity|protein K11-linked deubiquitination|ubiquitin binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|negative regulation of histone H2A K63-linked ubiquitination|negative regulation of double-strand break repair OTUD1 127.8211095 116.7199364 138.9222827 1.190218973 0.25122702 0.695187043 1 1.789722378 2.221920249 220213 OTU deubiquitinase 1 "GO:0004843,GO:0008234,GO:0016579,GO:0018215,GO:0070536" thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|protein K63-linked deubiquitination OTUD3 192.6325554 202.9911937 182.2739171 0.897940023 -0.155309011 0.783170765 1 1.455996013 1.363714458 23252 OTU deubiquitinase 3 "GO:0004843,GO:0005515,GO:0005737,GO:0005829,GO:0008234,GO:0016579,GO:0018215,GO:0035871,GO:0044313,GO:0050821,GO:0051898,GO:0071108,GO:1990167" thiol-dependent ubiquitin-specific protease activity|protein binding|cytoplasm|cytosol|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|protein K11-linked deubiquitination|protein K6-linked deubiquitination|protein stabilization|negative regulation of protein kinase B signaling|protein K48-linked deubiquitination|protein K27-linked deubiquitination OTUD4 1724.507176 1704.111071 1744.903282 1.023937531 0.034127701 0.918474811 1 10.44755042 11.15844988 54726 OTU deubiquitinase 4 "GO:0003723,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0008234,GO:0016579,GO:0018215,GO:0034122,GO:0045087,GO:0060090,GO:0061578,GO:0070536,GO:0071108,GO:1901537,GO:1903093,GO:2000660" RNA binding|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|negative regulation of toll-like receptor signaling pathway|innate immune response|molecular adaptor activity|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|positive regulation of DNA demethylation|regulation of protein K48-linked deubiquitination|negative regulation of interleukin-1-mediated signaling pathway OTUD5 2280.348478 2219.708703 2340.988254 1.054637598 0.076747335 0.811441721 1 17.77678924 19.55566113 55593 OTU deubiquitinase 5 "GO:0004843,GO:0005829,GO:0008234,GO:0016579,GO:0018215,GO:0032480,GO:0032496,GO:0061578,GO:0070536,GO:0071108,GO:0101005,GO:1990380" thiol-dependent ubiquitin-specific protease activity|cytosol|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|negative regulation of type I interferon production|response to lipopolysaccharide|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|ubiquitinyl hydrolase activity|Lys48-specific deubiquitinase activity hsa04622 RIG-I-like receptor signaling pathway OTUD6B 550.2657251 605.9287131 494.6027371 0.816272156 -0.292877849 0.463983493 1 9.223971064 7.853601197 51633 OTU deubiquitinase 6B "GO:0004843,GO:0008234,GO:0008283,GO:0016281,GO:0016579,GO:0018215,GO:0043248" thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cell population proliferation|eukaryotic translation initiation factor 4F complex|protein deubiquitination|protein phosphopantetheinylation|proteasome assembly OTUD7A 7.045308675 10.14955968 3.941057666 0.388298388 -1.364762376 0.421596647 1 0.045218103 0.018314449 161725 OTU deubiquitinase 7A "GO:0003677,GO:0004843,GO:0005634,GO:0005737,GO:0005829,GO:0008234,GO:0008270,GO:0016579,GO:0018215,GO:0035871,GO:0043124,GO:0070530,GO:0070536,GO:0071108,GO:0071947" DNA binding|thiol-dependent ubiquitin-specific protease activity|nucleus|cytoplasm|cytosol|cysteine-type peptidase activity|zinc ion binding|protein deubiquitination|protein phosphopantetheinylation|protein K11-linked deubiquitination|negative regulation of I-kappaB kinase/NF-kappaB signaling|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process OTUD7B 1054.359118 1019.015792 1089.702445 1.069367573 0.096757835 0.783730767 1 4.098924232 4.572069578 56957 OTU deubiquitinase 7B "GO:0000122,GO:0001701,GO:0002250,GO:0002385,GO:0003677,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008234,GO:0008270,GO:0016579,GO:0018215,GO:0032717,GO:0035871,GO:0043124,GO:0070530,GO:0070536,GO:0071108,GO:0071947,GO:1900181,GO:1990380" negative regulation of transcription by RNA polymerase II|in utero embryonic development|adaptive immune response|mucosal immune response|DNA binding|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|cytosol|cysteine-type peptidase activity|zinc ion binding|protein deubiquitination|protein phosphopantetheinylation|negative regulation of interleukin-8 production|protein K11-linked deubiquitination|negative regulation of I-kappaB kinase/NF-kappaB signaling|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of protein localization to nucleus|Lys48-specific deubiquitinase activity OTULIN 1297.704338 1388.459765 1206.94891 0.869271794 -0.202120762 0.550605602 1 4.467068282 4.050364505 90268 OTU deubiquitinase with linear linkage specificity "GO:0002040,GO:0004843,GO:0005515,GO:0005737,GO:0005829,GO:0008234,GO:0010803,GO:0016055,GO:0016567,GO:0018215,GO:0032088,GO:0045087,GO:0050728,GO:0060828,GO:0070431,GO:0071797,GO:1990108" sprouting angiogenesis|thiol-dependent ubiquitin-specific protease activity|protein binding|cytoplasm|cytosol|cysteine-type peptidase activity|regulation of tumor necrosis factor-mediated signaling pathway|Wnt signaling pathway|protein ubiquitination|protein phosphopantetheinylation|negative regulation of NF-kappaB transcription factor activity|innate immune response|negative regulation of inflammatory response|regulation of canonical Wnt signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|LUBAC complex|protein linear deubiquitination OTULINL 289.0966719 230.3950048 347.798339 1.50957413 0.594141605 0.214712209 1 4.215568717 6.637836448 54491 OTU deubiquitinase with linear linkage specificity like "GO:0005515,GO:0005635,GO:0005737,GO:0016579,GO:0019783,GO:0042406,GO:0043130" protein binding|nuclear envelope|cytoplasm|protein deubiquitination|ubiquitin-like protein-specific protease activity|extrinsic component of endoplasmic reticulum membrane|ubiquitin binding OTX1 79.99396962 80.1815215 79.80641774 0.995321818 -0.006765027 1 1 1.251050894 1.29883634 5013 orthodenticle homeobox 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0009952,GO:0022037,GO:0030901,GO:0042472,GO:0045944,GO:0048852,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|metencephalon development|midbrain development|inner ear morphogenesis|positive regulation of transcription by RNA polymerase II|diencephalon morphogenesis|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells OVCA2 49.12416564 57.8524902 40.39584108 0.698255874 -0.518172291 0.552062512 1 2.841924866 2.069870235 124641 OVCA2 serine hydrolase domain containing "GO:0005634,GO:0005737,GO:0016787,GO:0032526" nucleus|cytoplasm|hydrolase activity|response to retinoic acid OVGP1 7.030462899 9.134603715 4.926322083 0.539303317 -0.890831188 0.625563046 1 0.210671882 0.118510163 5016 oviductal glycoprotein 1 "GO:0004568,GO:0005576,GO:0005829,GO:0005975,GO:0006032,GO:0007339,GO:0007565,GO:0008061,GO:0015630,GO:0030133,GO:0035805,GO:0043231,GO:0098595,GO:2000360" chitinase activity|extracellular region|cytosol|carbohydrate metabolic process|chitin catabolic process|binding of sperm to zona pellucida|female pregnancy|chitin binding|microtubule cytoskeleton|transport vesicle|egg coat|intracellular membrane-bounded organelle|perivitelline space|negative regulation of binding of sperm to zona pellucida OVOL2 5.433800067 1.014955968 9.852644165 9.707459705 3.279093814 0.119754137 1 0.027154749 0.274958604 58495 ovo like zinc finger 2 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001525,GO:0001755,GO:0001842,GO:0001947,GO:0003682,GO:0005515,GO:0005634,GO:0006357,GO:0009913,GO:0009953,GO:0010628,GO:0010629,GO:0010719,GO:0010837,GO:0045618,GO:0045944,GO:0046872,GO:0048557,GO:0060214,GO:0060347,GO:0060390,GO:0060716,GO:0071560,GO:1990837,GO:2000647" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|neural crest cell migration|neural fold formation|heart looping|chromatin binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|epidermal cell differentiation|dorsal/ventral pattern formation|positive regulation of gene expression|negative regulation of gene expression|negative regulation of epithelial to mesenchymal transition|regulation of keratinocyte proliferation|positive regulation of keratinocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|embryonic digestive tract morphogenesis|endocardium formation|heart trabecula formation|regulation of SMAD protein signal transduction|labyrinthine layer blood vessel development|cellular response to transforming growth factor beta stimulus|sequence-specific double-stranded DNA binding|negative regulation of stem cell proliferation" zf-C2H2 OXA1L 3315.403144 3266.128306 3364.677983 1.030173241 0.042886971 0.893598212 1 58.95148842 63.34625857 5018 OXA1L mitochondrial inner membrane protein "GO:0005515,GO:0005739,GO:0005746,GO:0005759,GO:0009060,GO:0031305,GO:0031966,GO:0032592,GO:0032780,GO:0032977,GO:0032979,GO:0032981,GO:0032991,GO:0033615,GO:0033617,GO:0042803,GO:0051205,GO:0051262,GO:0051354,GO:0055114,GO:0065003,GO:0070125,GO:0070126,GO:0097177" protein binding|mitochondrion|mitochondrial respirasome|mitochondrial matrix|aerobic respiration|integral component of mitochondrial inner membrane|mitochondrial membrane|integral component of mitochondrial membrane|negative regulation of ATPase activity|membrane insertase activity|protein insertion into mitochondrial inner membrane from matrix|mitochondrial respiratory chain complex I assembly|protein-containing complex|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial cytochrome c oxidase assembly|protein homodimerization activity|protein insertion into membrane|protein tetramerization|negative regulation of oxidoreductase activity|oxidation-reduction process|protein-containing complex assembly|mitochondrial translational elongation|mitochondrial translational termination|mitochondrial ribosome binding hsa03060 Protein export OXCT1 895.1904185 880.9817805 909.3990565 1.032256372 0.045801324 0.901627196 1 11.06063938 11.90923143 5019 3-oxoacid CoA-transferase 1 "GO:0005739,GO:0005759,GO:0007420,GO:0007507,GO:0007584,GO:0008260,GO:0008410,GO:0009725,GO:0014823,GO:0035774,GO:0042182,GO:0042493,GO:0042594,GO:0042802,GO:0045471,GO:0046950,GO:0046952,GO:0060612" mitochondrion|mitochondrial matrix|brain development|heart development|response to nutrient|3-oxoacid CoA-transferase activity|CoA-transferase activity|response to hormone|response to activity|positive regulation of insulin secretion involved in cellular response to glucose stimulus|ketone catabolic process|response to drug|response to starvation|identical protein binding|response to ethanol|cellular ketone body metabolic process|ketone body catabolic process|adipose tissue development "hsa00072,hsa00280,hsa00650" "Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism" OXCT2 10.49373413 10.14955968 10.83790858 1.067820568 0.094669242 1 1 0.281511168 0.313552191 64064 3-oxoacid CoA-transferase 2 "GO:0005739,GO:0005759,GO:0008260,GO:0008410,GO:0031514,GO:0046950,GO:0046952" mitochondrion|mitochondrial matrix|3-oxoacid CoA-transferase activity|CoA-transferase activity|motile cilium|cellular ketone body metabolic process|ketone body catabolic process "hsa00072,hsa00280,hsa00650" "Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism" OXLD1 256.5356873 260.8436839 252.2276906 0.966968749 -0.04845883 0.930429362 1 8.414530183 8.487078923 339229 oxidoreductase like domain containing 1 OXNAD1 387.3840973 416.131947 358.6362476 0.861833008 -0.214519741 0.626836417 1 0.899015275 0.808176325 92106 oxidoreductase NAD binding domain containing 1 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016491,GO:0055114" molecular_function|protein binding|cellular_component|biological_process|oxidoreductase activity|oxidation-reduction process OXR1 1304.435409 1040.329868 1568.540951 1.507734229 0.592382145 0.079960433 1 8.930345378 14.04458722 55074 oxidation resistance 1 "GO:0003674,GO:0005634,GO:0005730,GO:0005739,GO:0006979,GO:0007628,GO:0016491,GO:0043524,GO:0051402,GO:0055114,GO:0071447,GO:1900408,GO:1902083,GO:1903204" molecular_function|nucleus|nucleolus|mitochondrion|response to oxidative stress|adult walking behavior|oxidoreductase activity|negative regulation of neuron apoptotic process|neuron apoptotic process|oxidation-reduction process|cellular response to hydroperoxide|negative regulation of cellular response to oxidative stress|negative regulation of peptidyl-cysteine S-nitrosylation|negative regulation of oxidative stress-induced neuron death OXSM 312.1180115 389.7430919 234.4929311 0.601660263 -0.732979019 0.117033761 1 5.049657885 3.169050899 54995 "3-oxoacyl-ACP synthase, mitochondrial" "GO:0004315,GO:0005739,GO:0005829,GO:0006633,GO:0006637,GO:0051790,GO:0051792" 3-oxoacyl-[acyl-carrier-protein] synthase activity|mitochondrion|cytosol|fatty acid biosynthetic process|acyl-CoA metabolic process|short-chain fatty acid biosynthetic process|medium-chain fatty acid biosynthetic process "hsa00061,hsa00780" Fatty acid biosynthesis|Biotin metabolism OXSR1 2592.702292 3198.126256 1987.278328 0.621388328 -0.686432952 0.031839871 0.799180761 31.9916675 20.73556621 9943 oxidative stress responsive kinase 1 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0006979,GO:0007165,GO:0007231,GO:0010820,GO:0018107,GO:0019901,GO:0035556,GO:0038116,GO:0038146,GO:0042802,GO:0046777,GO:0070062,GO:0071476,GO:0106310,GO:0106311,GO:1901017,GO:1990869" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|response to oxidative stress|signal transduction|osmosensory signaling pathway|positive regulation of T cell chemotaxis|peptidyl-threonine phosphorylation|protein kinase binding|intracellular signal transduction|chemokine (C-C motif) ligand 21 signaling pathway|chemokine (C-X-C motif) ligand 12 signaling pathway|identical protein binding|protein autophosphorylation|extracellular exosome|cellular hypotonic response|protein serine kinase activity|protein threonine kinase activity|negative regulation of potassium ion transmembrane transporter activity|cellular response to chemokine OXTR 27.65891094 38.5683268 16.74949508 0.434281092 -1.203298953 0.237509212 1 0.423352772 0.191773793 5021 oxytocin receptor "GO:0001967,GO:0001975,GO:0001992,GO:0004930,GO:0004990,GO:0005000,GO:0005886,GO:0005887,GO:0005902,GO:0005912,GO:0006936,GO:0007166,GO:0007186,GO:0007204,GO:0007507,GO:0007565,GO:0007595,GO:0007613,GO:0010701,GO:0016324,GO:0017046,GO:0021537,GO:0030431,GO:0032230,GO:0032355,GO:0032570,GO:0034059,GO:0034097,GO:0035176,GO:0042220,GO:0042277,GO:0042493,GO:0042711,GO:0042713,GO:0042755,GO:0043434,GO:0044849,GO:0045777,GO:0045907,GO:0048565,GO:0051965,GO:0051968,GO:0060137,GO:0060406,GO:0060455,GO:0070371,GO:0070474,GO:0120162" "suckling behavior|response to amphetamine|regulation of systemic arterial blood pressure by vasopressin|G protein-coupled receptor activity|oxytocin receptor activity|vasopressin receptor activity|plasma membrane|integral component of plasma membrane|microvillus|adherens junction|muscle contraction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|heart development|female pregnancy|lactation|memory|positive regulation of norepinephrine secretion|apical plasma membrane|peptide hormone binding|telencephalon development|sleep|positive regulation of synaptic transmission, GABAergic|response to estradiol|response to progesterone|response to anoxia|response to cytokine|social behavior|response to cocaine|peptide binding|response to drug|maternal behavior|sperm ejaculation|eating behavior|response to peptide hormone|estrous cycle|positive regulation of blood pressure|positive regulation of vasoconstriction|digestive tract development|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|maternal process involved in parturition|positive regulation of penile erection|negative regulation of gastric acid secretion|ERK1 and ERK2 cascade|positive regulation of uterine smooth muscle contraction|positive regulation of cold-induced thermogenesis" "hsa04020,hsa04024,hsa04080,hsa04921" Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Oxytocin signaling pathway P2RX3 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.028337342 0 5024 purinergic receptor P2X 3 "GO:0001614,GO:0001666,GO:0004931,GO:0005524,GO:0005639,GO:0005791,GO:0005794,GO:0005886,GO:0005887,GO:0007165,GO:0007274,GO:0007596,GO:0009408,GO:0009409,GO:0009612,GO:0009743,GO:0010524,GO:0014832,GO:0015672,GO:0019228,GO:0030432,GO:0035590,GO:0042802,GO:0043025,GO:0043195,GO:0043197,GO:0043235,GO:0045121,GO:0048167,GO:0050850,GO:0050909,GO:0060079,GO:0061368,GO:0070207,GO:0071318,GO:0098655,GO:0098685,GO:0098686,GO:0099056,GO:1904058" purinergic nucleotide receptor activity|response to hypoxia|extracellularly ATP-gated cation channel activity|ATP binding|integral component of nuclear inner membrane|rough endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|signal transduction|neuromuscular synaptic transmission|blood coagulation|response to heat|response to cold|response to mechanical stimulus|response to carbohydrate|positive regulation of calcium ion transport into cytosol|urinary bladder smooth muscle contraction|monovalent inorganic cation transport|neuronal action potential|peristalsis|purinergic nucleotide receptor signaling pathway|identical protein binding|neuronal cell body|terminal bouton|dendritic spine|receptor complex|membrane raft|regulation of synaptic plasticity|positive regulation of calcium-mediated signaling|sensory perception of taste|excitatory postsynaptic potential|behavioral response to formalin induced pain|protein homotrimerization|cellular response to ATP|cation transmembrane transport|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|integral component of presynaptic membrane|positive regulation of sensory perception of pain "hsa04020,hsa04080,hsa04742" Calcium signaling pathway|Neuroactive ligand-receptor interaction|Taste transduction P2RX4 1053.912261 1190.543351 917.2811718 0.770472718 -0.376184222 0.281552886 1 34.49474871 27.7221035 5025 purinergic receptor P2X 4 "GO:0001614,GO:0001894,GO:0002028,GO:0002931,GO:0004931,GO:0005102,GO:0005507,GO:0005515,GO:0005524,GO:0005639,GO:0005765,GO:0005886,GO:0005887,GO:0007165,GO:0007596,GO:0008217,GO:0008270,GO:0010524,GO:0010614,GO:0014069,GO:0016020,GO:0019228,GO:0019233,GO:0019722,GO:0030054,GO:0032308,GO:0033198,GO:0034220,GO:0034405,GO:0035590,GO:0042118,GO:0042802,GO:0043025,GO:0043195,GO:0043197,GO:0043536,GO:0044297,GO:0045296,GO:0045429,GO:0048266,GO:0048471,GO:0048678,GO:0050850,GO:0050920,GO:0050975,GO:0051897,GO:0051899,GO:0051928,GO:0055117,GO:0055119,GO:0060079,GO:0070062,GO:0070588,GO:0071294,GO:0071318,GO:0097190,GO:0099604,GO:1900027,GO:1904124,GO:1904141,GO:2001028" purinergic nucleotide receptor activity|tissue homeostasis|regulation of sodium ion transport|response to ischemia|extracellularly ATP-gated cation channel activity|signaling receptor binding|copper ion binding|protein binding|ATP binding|integral component of nuclear inner membrane|lysosomal membrane|plasma membrane|integral component of plasma membrane|signal transduction|blood coagulation|regulation of blood pressure|zinc ion binding|positive regulation of calcium ion transport into cytosol|negative regulation of cardiac muscle hypertrophy|postsynaptic density|membrane|neuronal action potential|sensory perception of pain|calcium-mediated signaling|cell junction|positive regulation of prostaglandin secretion|response to ATP|ion transmembrane transport|response to fluid shear stress|purinergic nucleotide receptor signaling pathway|endothelial cell activation|identical protein binding|neuronal cell body|terminal bouton|dendritic spine|positive regulation of blood vessel endothelial cell migration|cell body|cadherin binding|positive regulation of nitric oxide biosynthetic process|behavioral response to pain|perinuclear region of cytoplasm|response to axon injury|positive regulation of calcium-mediated signaling|regulation of chemotaxis|sensory perception of touch|positive regulation of protein kinase B signaling|membrane depolarization|positive regulation of calcium ion transport|regulation of cardiac muscle contraction|relaxation of cardiac muscle|excitatory postsynaptic potential|extracellular exosome|calcium ion transmembrane transport|cellular response to zinc ion|cellular response to ATP|apoptotic signaling pathway|ligand-gated calcium channel activity|regulation of ruffle assembly|microglial cell migration|positive regulation of microglial cell migration|positive regulation of endothelial cell chemotaxis "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction P2RX5 843.902729 809.9348628 877.8705951 1.08387802 0.116202404 0.751459343 1 19.91278812 22.51274289 5026 purinergic receptor P2X 5 "GO:0001614,GO:0004888,GO:0004931,GO:0005216,GO:0005524,GO:0005639,GO:0005829,GO:0005886,GO:0005887,GO:0007165,GO:0007399,GO:0007596,GO:0010524,GO:0033198,GO:0035590,GO:0050850,GO:0060079,GO:0098655,GO:0098794" purinergic nucleotide receptor activity|transmembrane signaling receptor activity|extracellularly ATP-gated cation channel activity|ion channel activity|ATP binding|integral component of nuclear inner membrane|cytosol|plasma membrane|integral component of plasma membrane|signal transduction|nervous system development|blood coagulation|positive regulation of calcium ion transport into cytosol|response to ATP|purinergic nucleotide receptor signaling pathway|positive regulation of calcium-mediated signaling|excitatory postsynaptic potential|cation transmembrane transport|postsynapse "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction P2RX6 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.068012621 0 9127 purinergic receptor P2X 6 "GO:0001614,GO:0004888,GO:0004931,GO:0005524,GO:0005639,GO:0005737,GO:0005886,GO:0005887,GO:0006936,GO:0007165,GO:0007596,GO:0014069,GO:0015267,GO:0030054,GO:0033198,GO:0035590,GO:0043025,GO:0043197,GO:0043235,GO:0044877,GO:0060079,GO:0098655,GO:0098688,GO:0098978,GO:0099060" purinergic nucleotide receptor activity|transmembrane signaling receptor activity|extracellularly ATP-gated cation channel activity|ATP binding|integral component of nuclear inner membrane|cytoplasm|plasma membrane|integral component of plasma membrane|muscle contraction|signal transduction|blood coagulation|postsynaptic density|channel activity|cell junction|response to ATP|purinergic nucleotide receptor signaling pathway|neuronal cell body|dendritic spine|receptor complex|protein-containing complex binding|excitatory postsynaptic potential|cation transmembrane transport|parallel fiber to Purkinje cell synapse|glutamatergic synapse|integral component of postsynaptic specialization membrane "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction P2RX7 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.009656949 0.039113029 5027 purinergic receptor P2X 7 "GO:0001530,GO:0001614,GO:0002028,GO:0002931,GO:0004931,GO:0005102,GO:0005515,GO:0005524,GO:0005639,GO:0005737,GO:0005886,GO:0005887,GO:0007166,GO:0007596,GO:0010524,GO:0010628,GO:0016020,GO:0017121,GO:0019233,GO:0030501,GO:0032059,GO:0032060,GO:0032731,GO:0033198,GO:0034767,GO:0035585,GO:0035590,GO:0042802,GO:0043409,GO:0045779,GO:0045794,GO:0045821,GO:0046931,GO:0051495,GO:0051709,GO:0051899,GO:0060079,GO:0070588,GO:0071318,GO:0097190,GO:0097191,GO:0098794,GO:1904172,GO:1905114" lipopolysaccharide binding|purinergic nucleotide receptor activity|regulation of sodium ion transport|response to ischemia|extracellularly ATP-gated cation channel activity|signaling receptor binding|protein binding|ATP binding|integral component of nuclear inner membrane|cytoplasm|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|blood coagulation|positive regulation of calcium ion transport into cytosol|positive regulation of gene expression|membrane|plasma membrane phospholipid scrambling|sensory perception of pain|positive regulation of bone mineralization|bleb|bleb assembly|positive regulation of interleukin-1 beta production|response to ATP|positive regulation of ion transmembrane transport|calcium-mediated signaling using extracellular calcium source|purinergic nucleotide receptor signaling pathway|identical protein binding|negative regulation of MAPK cascade|negative regulation of bone resorption|negative regulation of cell volume|positive regulation of glycolytic process|pore complex assembly|positive regulation of cytoskeleton organization|regulation of killing of cells of other organism|membrane depolarization|excitatory postsynaptic potential|calcium ion transmembrane transport|cellular response to ATP|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|postsynapse|positive regulation of bleb assembly|cell surface receptor signaling pathway involved in cell-cell signaling "hsa04020,hsa04080,hsa04621" Calcium signaling pathway|Neuroactive ligand-receptor interaction|NOD-like receptor signaling pathway P2RY1 27.1217414 35.52345889 18.72002391 0.526976384 -0.924189785 0.369111253 1 0.285170054 0.156751246 5028 purinergic receptor P2Y1 "GO:0001621,GO:0001934,GO:0001973,GO:0005515,GO:0005524,GO:0005739,GO:0005886,GO:0005887,GO:0005929,GO:0007166,GO:0007186,GO:0007193,GO:0007200,GO:0007204,GO:0007568,GO:0008347,GO:0008360,GO:0009612,GO:0009986,GO:0010469,GO:0010700,GO:0014069,GO:0016323,GO:0016324,GO:0019233,GO:0023019,GO:0030168,GO:0030425,GO:0031686,GO:0032962,GO:0035589,GO:0038023,GO:0042755,GO:0043270,GO:0043531,GO:0044297,GO:0045028,GO:0045031,GO:0045211,GO:0045944,GO:0046887,GO:0046982,GO:0051100,GO:0060406,GO:0070374,GO:0070848,GO:0071318,GO:0071415,GO:0072659,GO:0090075,GO:0097110,GO:0097746,GO:0098978,GO:0099059,GO:0099509,GO:2000300" G protein-coupled ADP receptor activity|positive regulation of protein phosphorylation|G protein-coupled adenosine receptor signaling pathway|protein binding|ATP binding|mitochondrion|plasma membrane|integral component of plasma membrane|cilium|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|aging|glial cell migration|regulation of cell shape|response to mechanical stimulus|cell surface|regulation of signaling receptor activity|negative regulation of norepinephrine secretion|postsynaptic density|basolateral plasma membrane|apical plasma membrane|sensory perception of pain|signal transduction involved in regulation of gene expression|platelet activation|dendrite|A1 adenosine receptor binding|positive regulation of inositol trisphosphate biosynthetic process|G protein-coupled purinergic nucleotide receptor signaling pathway|signaling receptor activity|eating behavior|positive regulation of ion transport|ADP binding|cell body|G protein-coupled purinergic nucleotide receptor activity|G protein-coupled ATP receptor activity|postsynaptic membrane|positive regulation of transcription by RNA polymerase II|positive regulation of hormone secretion|protein heterodimerization activity|negative regulation of binding|positive regulation of penile erection|positive regulation of ERK1 and ERK2 cascade|response to growth factor|cellular response to ATP|cellular response to purine-containing compound|protein localization to plasma membrane|relaxation of muscle|scaffold protein binding|blood vessel diameter maintenance|glutamatergic synapse|integral component of presynaptic active zone membrane|regulation of presynaptic cytosolic calcium ion concentration|regulation of synaptic vesicle exocytosis "hsa04015,hsa04080,hsa04611,hsa04742" Rap1 signaling pathway|Neuroactive ligand-receptor interaction|Platelet activation|Taste transduction P2RY2 973.8128875 1305.233375 642.3923996 0.492166697 -1.022781054 0.004140256 0.236266986 5.494594454 2.820744804 5029 purinergic receptor P2Y2 "GO:0005515,GO:0005886,GO:0005887,GO:0006873,GO:0007186,GO:0007200,GO:0035589,GO:0038023,GO:0045028,GO:0070257,GO:0071318,GO:0097746" protein binding|plasma membrane|integral component of plasma membrane|cellular ion homeostasis|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|G protein-coupled purinergic nucleotide receptor signaling pathway|signaling receptor activity|G protein-coupled purinergic nucleotide receptor activity|positive regulation of mucus secretion|cellular response to ATP|blood vessel diameter maintenance "hsa04080,hsa04750" Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels P2RY4 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.075631102 0.153162326 5030 pyrimidinergic receptor P2Y4 "GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0007186,GO:0007200,GO:0007204,GO:0016323,GO:0016324,GO:0030321,GO:0035589,GO:0045028,GO:0045030,GO:0071318,GO:0071380,GO:0098978,GO:0099059,GO:0099509,GO:2000300" protein binding|ATP binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|basolateral plasma membrane|apical plasma membrane|transepithelial chloride transport|G protein-coupled purinergic nucleotide receptor signaling pathway|G protein-coupled purinergic nucleotide receptor activity|G protein-coupled UTP receptor activity|cellular response to ATP|cellular response to prostaglandin E stimulus|glutamatergic synapse|integral component of presynaptic active zone membrane|regulation of presynaptic cytosolic calcium ion concentration|regulation of synaptic vesicle exocytosis "hsa04080,hsa04742" Neuroactive ligand-receptor interaction|Taste transduction P2RY6 614.0688959 791.6656553 436.4721365 0.551333929 -0.859001706 0.027773276 0.73667121 6.500498154 3.738327014 5031 pyrimidinergic receptor P2Y6 "GO:0001621,GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0006909,GO:0007186,GO:0007200,GO:0007202,GO:0031587,GO:0032962,GO:0035589,GO:0045029,GO:0045030,GO:0070374,GO:0071415,GO:1904707,GO:1905835" "G protein-coupled ADP receptor activity|G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|phagocytosis|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|positive regulation of inositol trisphosphate biosynthetic process|G protein-coupled purinergic nucleotide receptor signaling pathway|G protein-coupled UDP receptor activity|G protein-coupled UTP receptor activity|positive regulation of ERK1 and ERK2 cascade|cellular response to purine-containing compound|positive regulation of vascular associated smooth muscle cell proliferation|cellular response to pyrimidine ribonucleotide" hsa04080 Neuroactive ligand-receptor interaction P3H1 2375.30872 2750.530674 2000.086766 0.727163956 -0.459647405 0.150542383 1 54.80120982 41.56601783 64175 prolyl 3-hydroxylase 1 "GO:0003674,GO:0005506,GO:0005515,GO:0005518,GO:0005783,GO:0005788,GO:0006457,GO:0008285,GO:0010976,GO:0016020,GO:0018126,GO:0019511,GO:0019797,GO:0031418,GO:0032963,GO:0032991,GO:0050708,GO:0050821,GO:0055114,GO:0060348,GO:0061077,GO:0062023,GO:0070062,GO:1901874" molecular_function|iron ion binding|protein binding|collagen binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|negative regulation of cell population proliferation|positive regulation of neuron projection development|membrane|protein hydroxylation|peptidyl-proline hydroxylation|procollagen-proline 3-dioxygenase activity|L-ascorbic acid binding|collagen metabolic process|protein-containing complex|regulation of protein secretion|protein stabilization|oxidation-reduction process|bone development|chaperone-mediated protein folding|collagen-containing extracellular matrix|extracellular exosome|negative regulation of post-translational protein modification P3H2 594.2178714 748.0225487 440.4131942 0.588769944 -0.764224069 0.051702784 1 10.25296434 6.29667109 55214 prolyl 3-hydroxylase 2 "GO:0005506,GO:0005604,GO:0005654,GO:0005783,GO:0005788,GO:0005794,GO:0005829,GO:0008285,GO:0016529,GO:0019511,GO:0019797,GO:0031418,GO:0032963,GO:0043231,GO:0055114" iron ion binding|basement membrane|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|cytosol|negative regulation of cell population proliferation|sarcoplasmic reticulum|peptidyl-proline hydroxylation|procollagen-proline 3-dioxygenase activity|L-ascorbic acid binding|collagen metabolic process|intracellular membrane-bounded organelle|oxidation-reduction process P3H3 1778.52921 1928.41634 1628.642081 0.844548994 -0.243746975 0.454063713 1 37.12181094 32.70167013 10536 prolyl 3-hydroxylase 3 "GO:0005506,GO:0005783,GO:0008285,GO:0017185,GO:0019511,GO:0019797,GO:0031418,GO:0032963,GO:0032964,GO:0055114,GO:1902494" iron ion binding|endoplasmic reticulum|negative regulation of cell population proliferation|peptidyl-lysine hydroxylation|peptidyl-proline hydroxylation|procollagen-proline 3-dioxygenase activity|L-ascorbic acid binding|collagen metabolic process|collagen biosynthetic process|oxidation-reduction process|catalytic complex P3H4 1396.377753 1600.585562 1192.169944 0.744833624 -0.425009894 0.2041954 1 26.03211695 20.22482116 10609 prolyl 3-hydroxylase family member 4 (inactive) "GO:0000794,GO:0000795,GO:0005518,GO:0005730,GO:0005783,GO:0007130,GO:0017185,GO:0030199,GO:0032964,GO:0043231,GO:0046849,GO:1902494" condensed nuclear chromosome|synaptonemal complex|collagen binding|nucleolus|endoplasmic reticulum|synaptonemal complex assembly|peptidyl-lysine hydroxylation|collagen fibril organization|collagen biosynthetic process|intracellular membrane-bounded organelle|bone remodeling|catalytic complex P4HA1 3594.180526 5013.882484 2174.478567 0.43369157 -1.205258693 0.000184648 0.026070029 87.35309938 39.51620495 5033 prolyl 4-hydroxylase subunit alpha 1 "GO:0004656,GO:0005506,GO:0005515,GO:0005739,GO:0005783,GO:0005788,GO:0016020,GO:0016702,GO:0018401,GO:0031418,GO:0042802,GO:0043231,GO:0055114" "procollagen-proline 4-dioxygenase activity|iron ion binding|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen|membrane|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|L-ascorbic acid binding|identical protein binding|intracellular membrane-bounded organelle|oxidation-reduction process" hsa00330 Arginine and proline metabolism P4HA2 3842.725226 4593.690713 3091.759739 0.67304482 -0.571225514 0.073481134 1 43.69093503 30.67264689 8974 prolyl 4-hydroxylase subunit alpha 2 "GO:0004656,GO:0005506,GO:0005654,GO:0005783,GO:0005788,GO:0005829,GO:0009055,GO:0016702,GO:0018401,GO:0022900,GO:0031418,GO:0043231" "procollagen-proline 4-dioxygenase activity|iron ion binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|cytosol|electron transfer activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|electron transport chain|L-ascorbic acid binding|intracellular membrane-bounded organelle" hsa00330 Arginine and proline metabolism P4HA3 36.61536534 44.65806261 28.57266808 0.639809844 -0.644284905 0.497533699 1 1.003003693 0.669374833 283208 prolyl 4-hydroxylase subunit alpha 3 "GO:0004656,GO:0005506,GO:0005515,GO:0005783,GO:0005788,GO:0016702,GO:0018401,GO:0031418,GO:0055114" "procollagen-proline 4-dioxygenase activity|iron ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|L-ascorbic acid binding|oxidation-reduction process" hsa00330 Arginine and proline metabolism P4HB 18195.05423 21162.8469 15227.26156 0.719528031 -0.474877203 0.186644662 1 438.5530022 329.1438431 5034 prolyl 4-hydroxylase subunit beta "GO:0003723,GO:0003756,GO:0003779,GO:0004656,GO:0005178,GO:0005515,GO:0005576,GO:0005783,GO:0005788,GO:0005793,GO:0005829,GO:0005856,GO:0005925,GO:0006457,GO:0009897,GO:0015037,GO:0016222,GO:0016972,GO:0018215,GO:0018401,GO:0030027,GO:0032991,GO:0034378,GO:0034379,GO:0034975,GO:0034976,GO:0035722,GO:0038155,GO:0042470,GO:0043687,GO:0044267,GO:0045785,GO:0046598,GO:0046982,GO:0055114,GO:0070062,GO:0071456,GO:1900026,GO:1902175" RNA binding|protein disulfide isomerase activity|actin binding|procollagen-proline 4-dioxygenase activity|integrin binding|protein binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|cytosol|cytoskeleton|focal adhesion|protein folding|external side of plasma membrane|peptide disulfide oxidoreductase activity|procollagen-proline 4-dioxygenase complex|thiol oxidase activity|protein phosphopantetheinylation|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|lamellipodium|protein-containing complex|chylomicron assembly|very-low-density lipoprotein particle assembly|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|interleukin-12-mediated signaling pathway|interleukin-23-mediated signaling pathway|melanosome|post-translational protein modification|cellular protein metabolic process|positive regulation of cell adhesion|positive regulation of viral entry into host cell|protein heterodimerization activity|oxidation-reduction process|extracellular exosome|cellular response to hypoxia|positive regulation of substrate adhesion-dependent cell spreading|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum P4HTM 465.5587175 472.9694813 458.1479537 0.968662825 -0.04593352 0.917296872 1 11.07454262 11.18959483 54681 "prolyl 4-hydroxylase, transmembrane" "GO:0004656,GO:0005506,GO:0005509,GO:0005783,GO:0005789,GO:0016021,GO:0016706,GO:0018401,GO:0031418,GO:0045646,GO:0055114" procollagen-proline 4-dioxygenase activity|iron ion binding|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|2-oxoglutarate-dependent dioxygenase activity|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|L-ascorbic acid binding|regulation of erythrocyte differentiation|oxidation-reduction process PA2G4 4328.146347 4235.411256 4420.881437 1.043790359 0.061831982 0.847038769 1 89.90303373 97.88216306 5036 proliferation-associated 2G4 "GO:0003676,GO:0003714,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0006364,GO:0006417,GO:0016020,GO:0031625,GO:0035578,GO:0043066,GO:0043312,GO:0045597,GO:0045892,GO:0070062" "nucleic acid binding|transcription corepressor activity|RNA binding|protein binding|extracellular region|nucleus|nucleolus|cytoplasm|rRNA processing|regulation of translation|membrane|ubiquitin protein ligase binding|azurophil granule lumen|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of cell differentiation|negative regulation of transcription, DNA-templated|extracellular exosome" PAAF1 423.5743784 364.3691926 482.7795641 1.324973609 0.405963624 0.34206495 1 3.118285602 4.309620685 80227 proteasomal ATPase associated factor 1 "GO:0000502,GO:0005515,GO:0016032" proteasome complex|protein binding|viral process PABIR1 384.3716426 378.5785762 390.164709 1.030604301 0.043490519 0.927103751 1 3.484854478 3.746213527 116224 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 "GO:0004865,GO:0005515,GO:0005634,GO:0005737,GO:0030307,GO:0032436,GO:0032515,GO:0044818" protein serine/threonine phosphatase inhibitor activity|protein binding|nucleus|cytoplasm|positive regulation of cell growth|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of phosphoprotein phosphatase activity|mitotic G2/M transition checkpoint PABIR2 1052.450694 989.5820692 1115.31932 1.127060963 0.172565553 0.62250018 1 18.31828975 21.53516788 159090 PABIR family member 2 PABIR3 137.258072 88.30116925 186.2149747 2.108861936 1.076464647 0.079226778 1 0.717839922 1.579034742 159091 PABIR family member 3 PABPC1 39079.91072 35154.01492 43005.80652 1.22335405 0.290841993 0.476519785 1 618.8483976 789.6822284 26986 poly(A) binding protein cytoplasmic 1 "GO:0000184,GO:0000398,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0006378,GO:0006413,GO:0008022,GO:0008143,GO:0008266,GO:0008494,GO:0010494,GO:0016020,GO:0030027,GO:0031047,GO:0031252,GO:0036464,GO:0043488,GO:0045070,GO:0045727,GO:0048255,GO:0060213,GO:0070062,GO:0071013,GO:1900153,GO:1990904,GO:2000623" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|focal adhesion|mRNA polyadenylation|translational initiation|protein C-terminus binding|poly(A) binding|poly(U) RNA binding|translation activator activity|cytoplasmic stress granule|membrane|lamellipodium|gene silencing by RNA|cell leading edge|cytoplasmic ribonucleoprotein granule|regulation of mRNA stability|positive regulation of viral genome replication|positive regulation of translation|mRNA stabilization|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|extracellular exosome|catalytic step 2 spliceosome|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|ribonucleoprotein complex|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" "hsa03013,hsa03015,hsa03018" RNA transport|mRNA surveillance pathway|RNA degradation PABPC1L 1080.967939 1120.511389 1041.424488 0.929418923 -0.105599077 0.763250885 1 26.50628161 25.69663453 80336 poly(A) binding protein cytoplasmic 1 like "GO:0001556,GO:0003723,GO:0003730,GO:0005634,GO:0005829,GO:0006338,GO:0006378,GO:0008143,GO:0008266,GO:0010494,GO:0048096,GO:0051647,GO:0070062,GO:1990904" oocyte maturation|RNA binding|mRNA 3'-UTR binding|nucleus|cytosol|chromatin remodeling|mRNA polyadenylation|poly(A) binding|poly(U) RNA binding|cytoplasmic stress granule|chromatin-mediated maintenance of transcription|nucleus localization|extracellular exosome|ribonucleoprotein complex "hsa03013,hsa03015,hsa03018" RNA transport|mRNA surveillance pathway|RNA degradation PABPC3 48.49792145 48.71788648 48.27795641 0.990969845 -0.013086938 1 1 0.791083387 0.817708728 5042 poly(A) binding protein cytoplasmic 3 "GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008143,GO:0008266,GO:0010494,GO:0016071,GO:0070062,GO:1990904" RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|poly(A) binding|poly(U) RNA binding|cytoplasmic stress granule|mRNA metabolic process|extracellular exosome|ribonucleoprotein complex "hsa03013,hsa03015,hsa03018" RNA transport|mRNA surveillance pathway|RNA degradation PABPC4 3717.462534 3304.696633 4130.228434 1.249805623 0.321703736 0.312368896 1 53.26900897 69.44372701 8761 poly(A) binding protein cytoplasmic 4 "GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006396,GO:0006401,GO:0006412,GO:0007596,GO:0008143,GO:0008266,GO:0010494,GO:0017130,GO:0043488,GO:0061515,GO:1990904" RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|RNA processing|RNA catabolic process|translation|blood coagulation|poly(A) binding|poly(U) RNA binding|cytoplasmic stress granule|poly(C) RNA binding|regulation of mRNA stability|myeloid cell development|ribonucleoprotein complex "hsa03013,hsa03015,hsa03018" RNA transport|mRNA surveillance pathway|RNA degradation PABPC4L 173.2620389 124.8395841 221.6844937 1.775754824 0.828432405 0.143348952 1 1.254500898 2.323645701 132430 poly(A) binding protein cytoplasmic 4 like "GO:0003723,GO:0003730,GO:0005634,GO:0005829,GO:0008143,GO:0008266,GO:0010494,GO:1990904" RNA binding|mRNA 3'-UTR binding|nucleus|cytosol|poly(A) binding|poly(U) RNA binding|cytoplasmic stress granule|ribonucleoprotein complex "hsa03013,hsa03015,hsa03018" RNA transport|mRNA surveillance pathway|RNA degradation PABPN1 164.3177087 153.2583512 175.3770661 1.144323065 0.19449441 0.742427972 1 3.908355905 4.665075599 8106 poly(A) binding protein nuclear 1 "GO:0000165,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006369,GO:0006396,GO:0006936,GO:0016607,GO:0016973,GO:0031124,GO:0042405,GO:0046778,GO:0070063,GO:0071222,GO:1904247,GO:1990904" "MAPK cascade|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|termination of RNA polymerase II transcription|RNA processing|muscle contraction|nuclear speck|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|nuclear inclusion body|modification by virus of host mRNA processing|RNA polymerase binding|cellular response to lipopolysaccharide|positive regulation of polynucleotide adenylyltransferase activity|ribonucleoprotein complex" "hsa03015,hsa05164" mRNA surveillance pathway|Influenza A PACC1 351.9794046 353.204677 350.7541323 0.99306197 -0.010044346 0.989349576 1 5.813640188 6.021995541 55248 proton activated chloride channel 1 "GO:0005515,GO:0005887,GO:0006821,GO:0009986,GO:0034707,GO:0061797,GO:1902476" protein binding|integral component of plasma membrane|chloride transport|cell surface|chloride channel complex|pH-gated chloride channel activity|chloride transmembrane transport PACRGL 153.7321783 170.5126027 136.9517539 0.803176726 -0.316210631 0.595250906 1 3.900569916 3.267797315 133015 parkin coregulated like GO:0005515 protein binding PACS1 2516.011504 2333.383771 2698.639237 1.156534673 0.209808519 0.510992926 1 19.76545515 23.84412592 55690 phosphofurin acidic cluster sorting protein 1 "GO:0005515,GO:0005794,GO:0005829,GO:0030137,GO:0034067,GO:0044325,GO:0050690,GO:0072659" protein binding|Golgi apparatus|cytosol|COPI-coated vesicle|protein localization to Golgi apparatus|ion channel binding|regulation of defense response to virus by virus|protein localization to plasma membrane PACS2 953.0401871 1030.180308 875.9000663 0.850239574 -0.234058684 0.510897187 1 7.917298685 7.021570719 23241 phosphofurin acidic cluster sorting protein 2 "GO:0000045,GO:0005515,GO:0005739,GO:0005783,GO:0006915,GO:0016032,GO:0032469,GO:0034497,GO:0044325,GO:0072659,GO:1990456" autophagosome assembly|protein binding|mitochondrion|endoplasmic reticulum|apoptotic process|viral process|endoplasmic reticulum calcium ion homeostasis|protein localization to phagophore assembly site|ion channel binding|protein localization to plasma membrane|mitochondrion-endoplasmic reticulum membrane tethering PACSIN2 2209.015285 2293.800489 2124.230082 0.926074475 -0.110799876 0.730273924 1 30.21401891 29.1857152 11252 protein kinase C and casein kinase substrate in neurons 2 "GO:0005215,GO:0005515,GO:0005543,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0005911,GO:0005925,GO:0007010,GO:0016607,GO:0019898,GO:0030036,GO:0030100,GO:0030659,GO:0032587,GO:0036010,GO:0042802,GO:0043231,GO:0045296,GO:0045806,GO:0048858,GO:0050804,GO:0055038,GO:0061024,GO:0070062,GO:0070300,GO:0070836,GO:0072584,GO:0097320,GO:0098978" transporter activity|protein binding|phospholipid binding|cytoplasm|endosome|early endosome|cytosol|cytoskeleton|plasma membrane|caveola|cell-cell junction|focal adhesion|cytoskeleton organization|nuclear speck|extrinsic component of membrane|actin cytoskeleton organization|regulation of endocytosis|cytoplasmic vesicle membrane|ruffle membrane|protein localization to endosome|identical protein binding|intracellular membrane-bounded organelle|cadherin binding|negative regulation of endocytosis|cell projection morphogenesis|modulation of chemical synaptic transmission|recycling endosome membrane|membrane organization|extracellular exosome|phosphatidic acid binding|caveola assembly|caveolin-mediated endocytosis|plasma membrane tubulation|glutamatergic synapse PACSIN3 895.8639216 859.6677052 932.0601381 1.084209785 0.116643933 0.747626829 1 20.94234562 23.68397396 29763 protein kinase C and casein kinase substrate in neurons 3 "GO:0005515,GO:0005543,GO:0005737,GO:0005768,GO:0005829,GO:0005856,GO:0005886,GO:0006897,GO:0007010,GO:0008092,GO:0008289,GO:0019855,GO:0030100,GO:0042802,GO:0045806,GO:0051044,GO:0051926,GO:0070062,GO:0097320" protein binding|phospholipid binding|cytoplasm|endosome|cytosol|cytoskeleton|plasma membrane|endocytosis|cytoskeleton organization|cytoskeletal protein binding|lipid binding|calcium channel inhibitor activity|regulation of endocytosis|identical protein binding|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis|negative regulation of calcium ion transport|extracellular exosome|plasma membrane tubulation PADI1 16.12052929 24.35894324 7.882115332 0.32358199 -1.627796782 0.179044245 1 0.299950047 0.101239317 29943 peptidyl arginine deiminase 1 "GO:0004668,GO:0005509,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0018101,GO:0036414" protein-arginine deiminase activity|calcium ion binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin organization|protein citrullination|histone citrullination PADI2 108.2588358 193.85659 22.66108158 0.116896112 -3.096701153 1.93E-05 0.004517723 2.139497145 0.260872143 11240 peptidyl arginine deiminase 2 "GO:0004668,GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006325,GO:0010848,GO:0018101,GO:0021762,GO:0030331,GO:0030520,GO:0035327,GO:0035578,GO:0036413,GO:0036414,GO:0042803,GO:0043312,GO:0048096,GO:0070062,GO:0070100,GO:1901624,GO:1990830" protein-arginine deiminase activity|calcium ion binding|extracellular region|nucleus|cytoplasm|cytosol|chromatin organization|regulation of chromatin disassembly|protein citrullination|substantia nigra development|estrogen receptor binding|intracellular estrogen receptor signaling pathway|transcriptionally active chromatin|azurophil granule lumen|histone H3-R26 citrullination|histone citrullination|protein homodimerization activity|neutrophil degranulation|chromatin-mediated maintenance of transcription|extracellular exosome|negative regulation of chemokine-mediated signaling pathway|negative regulation of lymphocyte chemotaxis|cellular response to leukemia inhibitory factor PADI3 22.83650929 45.67301858 0 0 #NAME? 4.30E-05 0.007977959 0.449335133 0 51702 peptidyl arginine deiminase 3 "GO:0004668,GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006325,GO:0018101,GO:0036414,GO:0042802" protein-arginine deiminase activity|calcium ion binding|protein binding|nucleus|cytoplasm|cytosol|chromatin organization|protein citrullination|histone citrullination|identical protein binding PADI4 33.4044723 60.8973581 5.911586499 0.097074597 -3.364762376 0.001779861 0.132156273 1.023303369 0.103615787 23569 peptidyl arginine deiminase 4 "GO:0004668,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0006334,GO:0006338,GO:0006464,GO:0018101,GO:0019827,GO:0032991,GO:0034618,GO:0036413,GO:0036414,GO:0042802,GO:0045087" protein-arginine deiminase activity|calcium ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin organization|nucleosome assembly|chromatin remodeling|cellular protein modification process|protein citrullination|stem cell population maintenance|protein-containing complex|arginine binding|histone H3-R26 citrullination|histone citrullination|identical protein binding|innate immune response PAEP 1295.087029 1815.756227 774.4178314 0.426498789 -1.229386451 0.000330761 0.041898412 86.59288824 38.52263246 5047 progestagen associated endometrial protein "GO:0005515,GO:0005549,GO:0005576,GO:0005615,GO:0006915,GO:0007275,GO:0032725,GO:0036094,GO:1902491,GO:2000359" protein binding|odorant binding|extracellular region|extracellular space|apoptotic process|multicellular organism development|positive regulation of granulocyte macrophage colony-stimulating factor production|small molecule binding|negative regulation of sperm capacitation|regulation of binding of sperm to zona pellucida PAF1 1231.70523 1220.99203 1242.418429 1.017548353 0.025097352 0.94376687 1 28.1086086 29.83392088 54623 "PAF1 homolog, Paf1/RNA polymerase II complex component" "GO:0000122,GO:0000993,GO:0001711,GO:0003682,GO:0005515,GO:0005654,GO:0005737,GO:0006366,GO:0006368,GO:0006378,GO:0010390,GO:0016020,GO:0016055,GO:0016567,GO:0016584,GO:0016593,GO:0019827,GO:0030054,GO:0031062,GO:0031442,GO:0033523,GO:0034504,GO:0035327,GO:0045638,GO:0071222,GO:1902808" negative regulation of transcription by RNA polymerase II|RNA polymerase II complex binding|endodermal cell fate commitment|chromatin binding|protein binding|nucleoplasm|cytoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA polyadenylation|histone monoubiquitination|membrane|Wnt signaling pathway|protein ubiquitination|nucleosome positioning|Cdc73/Paf1 complex|stem cell population maintenance|cell junction|positive regulation of histone methylation|positive regulation of mRNA 3'-end processing|histone H2B ubiquitination|protein localization to nucleus|transcriptionally active chromatin|negative regulation of myeloid cell differentiation|cellular response to lipopolysaccharide|positive regulation of cell cycle G1/S phase transition PAFAH1B1 3267.415176 3555.390757 2979.439596 0.838006227 -0.25496713 0.42287183 1 29.85707166 26.09818986 5048 platelet activating factor acetylhydrolase 1b regulatory subunit 1 "GO:0000086,GO:0000132,GO:0000226,GO:0000235,GO:0000776,GO:0001675,GO:0001764,GO:0005515,GO:0005635,GO:0005813,GO:0005829,GO:0005875,GO:0005881,GO:0005938,GO:0007017,GO:0007097,GO:0007268,GO:0007281,GO:0007405,GO:0007611,GO:0008017,GO:0008090,GO:0008201,GO:0008247,GO:0008344,GO:0010389,GO:0016042,GO:0019226,GO:0021540,GO:0021766,GO:0021819,GO:0021987,GO:0030036,GO:0031023,GO:0031252,GO:0031514,GO:0031965,GO:0034452,GO:0038026,GO:0042802,GO:0043005,GO:0043025,GO:0043274,GO:0045202,GO:0046469,GO:0046982,GO:0047496,GO:0048471,GO:0048854,GO:0050885,GO:0051010,GO:0051012,GO:0051219,GO:0051301,GO:0070062,GO:0070840,GO:0097711,GO:1904115,GO:2000574" G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|microtubule cytoskeleton organization|astral microtubule|kinetochore|acrosome assembly|neuron migration|protein binding|nuclear envelope|centrosome|cytosol|microtubule associated complex|cytoplasmic microtubule|cell cortex|microtubule-based process|nuclear migration|chemical synaptic transmission|germ cell development|neuroblast proliferation|learning or memory|microtubule binding|retrograde axonal transport|heparin binding|1-alkyl-2-acetylglycerophosphocholine esterase complex|adult locomotory behavior|regulation of G2/M transition of mitotic cell cycle|lipid catabolic process|transmission of nerve impulse|corpus callosum morphogenesis|hippocampus development|layer formation in cerebral cortex|cerebral cortex development|actin cytoskeleton organization|microtubule organizing center organization|cell leading edge|motile cilium|nuclear membrane|dynactin binding|reelin-mediated signaling pathway|identical protein binding|neuron projection|neuronal cell body|phospholipase binding|synapse|platelet activating factor metabolic process|protein heterodimerization activity|vesicle transport along microtubule|perinuclear region of cytoplasm|brain morphogenesis|neuromuscular process controlling balance|microtubule plus-end binding|microtubule sliding|phosphoprotein binding|cell division|extracellular exosome|dynein complex binding|ciliary basal body-plasma membrane docking|axon cytoplasm|regulation of microtubule motor activity hsa00565 Ether lipid metabolism PAFAH1B2 3521.271943 3532.04677 3510.497116 0.99389882 -0.008829104 0.978844254 1 26.46629806 27.43792747 5049 platelet activating factor acetylhydrolase 1b catalytic subunit 2 "GO:0001650,GO:0003847,GO:0005515,GO:0005576,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0007283,GO:0007420,GO:0008247,GO:0016042,GO:0016239,GO:0034774,GO:0042803,GO:0043312,GO:0044877,GO:0046982,GO:0047179,GO:0070062,GO:1904813" fibrillar center|1-alkyl-2-acetylglycerophosphocholine esterase activity|protein binding|extracellular region|nucleolus|cytoplasm|cytosol|plasma membrane|lipid metabolic process|spermatogenesis|brain development|1-alkyl-2-acetylglycerophosphocholine esterase complex|lipid catabolic process|positive regulation of macroautophagy|secretory granule lumen|protein homodimerization activity|neutrophil degranulation|protein-containing complex binding|protein heterodimerization activity|platelet-activating factor acetyltransferase activity|extracellular exosome|ficolin-1-rich granule lumen hsa00565 Ether lipid metabolism PAFAH1B3 740.5323589 714.5290017 766.5357161 1.072784609 0.101360445 0.78868595 1 31.25075409 34.96946318 5050 platelet activating factor acetylhydrolase 1b catalytic subunit 3 "GO:0003847,GO:0005515,GO:0005737,GO:0005829,GO:0006629,GO:0007283,GO:0007399,GO:0007420,GO:0008247,GO:0016020,GO:0016042,GO:0042802,GO:0042803,GO:0044877,GO:0046982,GO:0047179" 1-alkyl-2-acetylglycerophosphocholine esterase activity|protein binding|cytoplasm|cytosol|lipid metabolic process|spermatogenesis|nervous system development|brain development|1-alkyl-2-acetylglycerophosphocholine esterase complex|membrane|lipid catabolic process|identical protein binding|protein homodimerization activity|protein-containing complex binding|protein heterodimerization activity|platelet-activating factor acetyltransferase activity hsa00565 Ether lipid metabolism PAFAH2 222.0068953 257.798816 186.2149747 0.722326726 -0.469276544 0.368840694 1 2.916372698 2.197316605 5051 platelet activating factor acetylhydrolase 2 "GO:0003847,GO:0005543,GO:0005737,GO:0005789,GO:0006629,GO:0007596,GO:0016042,GO:0043066,GO:0047179" 1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding|cytoplasm|endoplasmic reticulum membrane|lipid metabolic process|blood coagulation|lipid catabolic process|negative regulation of apoptotic process|platelet-activating factor acetyltransferase activity hsa00565 Ether lipid metabolism PAG1 930.9053886 1167.199364 694.6114137 0.595109486 -0.74877298 0.036428012 0.86078571 5.413418511 3.360349168 55824 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 "GO:0002250,GO:0005515,GO:0005886,GO:0007165,GO:0016021,GO:0035556,GO:0035591,GO:0042169,GO:0045121,GO:0050852,GO:0050863,GO:0050868" adaptive immune response|protein binding|plasma membrane|signal transduction|integral component of membrane|intracellular signal transduction|signaling adaptor activity|SH2 domain binding|membrane raft|T cell receptor signaling pathway|regulation of T cell activation|negative regulation of T cell activation PAGR1 758.8109689 819.0694665 698.5524713 0.852861082 -0.229617327 0.537427529 1 10.70804826 9.525867725 79447 PAXIP1 associated glutamate rich protein 1 "GO:0005515,GO:0005634,GO:0006281,GO:0006310,GO:0030331,GO:0033148,GO:0035097,GO:0044666,GO:0045944,GO:0051568,GO:1902808" protein binding|nucleus|DNA repair|DNA recombination|estrogen receptor binding|positive regulation of intracellular estrogen receptor signaling pathway|histone methyltransferase complex|MLL3/4 complex|positive regulation of transcription by RNA polymerase II|histone H3-K4 methylation|positive regulation of cell cycle G1/S phase transition PAICS 3434.117612 3939.044113 2929.19111 0.743629933 -0.427343251 0.179473707 1 44.77080077 34.72703101 10606 phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase "GO:0004638,GO:0004639,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006189,GO:0009113,GO:0009168,GO:0016020,GO:0042802,GO:0043727,GO:0045296,GO:0070062" phosphoribosylaminoimidazole carboxylase activity|phosphoribosylaminoimidazolesuccinocarboxamide synthase activity|protein binding|ATP binding|cytoplasm|cytosol|'de novo' IMP biosynthetic process|purine nucleobase biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|membrane|identical protein binding|5-amino-4-imidazole carboxylate lyase activity|cadherin binding|extracellular exosome hsa00230 Purine metabolism PAIP1 1469.946223 1207.797602 1732.094844 1.434093627 0.520139216 0.117962228 1 18.93243197 28.32042984 10605 poly(A) binding protein interacting protein 1 "GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0006413,GO:0006446,GO:0008494,GO:0045727,GO:0048255" RNA binding|protein binding|cytoplasm|cytosol|translational initiation|regulation of translational initiation|translation activator activity|positive regulation of translation|mRNA stabilization hsa03013 RNA transport PAIP2 2291.220038 2356.727759 2225.712317 0.944407902 -0.082517983 0.797402271 1 41.35826297 40.74157669 51247 poly(A) binding protein interacting protein 2 "GO:0000900,GO:0003729,GO:0005515,GO:0005737,GO:0007283,GO:0007613,GO:0017148,GO:0030371,GO:0045947,GO:1900271" "translation repressor activity, mRNA regulatory element binding|mRNA binding|protein binding|cytoplasm|spermatogenesis|memory|negative regulation of translation|translation repressor activity|negative regulation of translational initiation|regulation of long-term synaptic potentiation" PAIP2B 121.1645126 99.4656849 142.8633404 1.436307814 0.522364965 0.413874161 1 0.773822741 1.159324307 400961 poly(A) binding protein interacting protein 2B "GO:0000900,GO:0005515,GO:0005737,GO:0017148,GO:0030371,GO:0045947" "translation repressor activity, mRNA regulatory element binding|protein binding|cytoplasm|negative regulation of translation|translation repressor activity|negative regulation of translational initiation" PAK1 1287.959819 1160.094672 1415.824967 1.22043916 0.287400377 0.396045498 1 13.15894794 16.75148191 5058 p21 (RAC1) activated kinase 1 "GO:0000165,GO:0001666,GO:0001726,GO:0001934,GO:0002223,GO:0004672,GO:0004674,GO:0005515,GO:0005518,GO:0005524,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005911,GO:0005925,GO:0006338,GO:0006468,GO:0006887,GO:0006915,GO:0006974,GO:0007165,GO:0008284,GO:0010763,GO:0014704,GO:0016477,GO:0019901,GO:0021549,GO:0030010,GO:0030018,GO:0030027,GO:0030335,GO:0030424,GO:0030425,GO:0031098,GO:0031116,GO:0031267,GO:0031295,GO:0031532,GO:0031965,GO:0032147,GO:0032587,GO:0032869,GO:0032991,GO:0033138,GO:0033148,GO:0038095,GO:0038096,GO:0042060,GO:0043507,GO:0045773,GO:0046628,GO:0046777,GO:0048012,GO:0048013,GO:0048754,GO:0048812,GO:0050770,GO:0050852,GO:0051496,GO:0060244,GO:0061052,GO:0071437,GO:0090314,GO:0106310,GO:0106311,GO:1904707,GO:1904754" MAPK cascade|response to hypoxia|ruffle|positive regulation of protein phosphorylation|stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein binding|collagen binding|ATP binding|nucleoplasm|chromosome|cytoplasm|cytosol|actin filament|plasma membrane|cell-cell junction|focal adhesion|chromatin remodeling|protein phosphorylation|exocytosis|apoptotic process|cellular response to DNA damage stimulus|signal transduction|positive regulation of cell population proliferation|positive regulation of fibroblast migration|intercalated disc|cell migration|protein kinase binding|cerebellum development|establishment of cell polarity|Z disc|lamellipodium|positive regulation of cell migration|axon|dendrite|stress-activated protein kinase signaling cascade|positive regulation of microtubule polymerization|small GTPase binding|T cell costimulation|actin cytoskeleton reorganization|nuclear membrane|activation of protein kinase activity|ruffle membrane|cellular response to insulin stimulus|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|positive regulation of intracellular estrogen receptor signaling pathway|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|wound healing|positive regulation of JUN kinase activity|positive regulation of axon extension|positive regulation of insulin receptor signaling pathway|protein autophosphorylation|hepatocyte growth factor receptor signaling pathway|ephrin receptor signaling pathway|branching morphogenesis of an epithelial tube|neuron projection morphogenesis|regulation of axonogenesis|T cell receptor signaling pathway|positive regulation of stress fiber assembly|negative regulation of cell proliferation involved in contact inhibition|negative regulation of cell growth involved in cardiac muscle cell development|invadopodium|positive regulation of protein targeting to membrane|protein serine kinase activity|protein threonine kinase activity|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration "hsa04010,hsa04012,hsa04014,hsa04024,hsa04062,hsa04360,hsa04392,hsa04510,hsa04625,hsa04650,hsa04660,hsa04666,hsa04810,hsa05120,hsa05130,hsa05132,hsa05170,hsa05205,hsa05211" MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Axon guidance|Hippo signaling pathway - multiple species|Focal adhesion|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Salmonella infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer|Renal cell carcinoma PAK1IP1 299.7010075 349.1448531 250.2571618 0.716771734 -0.480414349 0.310337399 1 8.953394988 6.693982067 55003 PAK1 interacting protein 1 "GO:0005515,GO:0005730,GO:0008283,GO:0009968,GO:0042273,GO:0060021,GO:1901796" protein binding|nucleolus|cell population proliferation|negative regulation of signal transduction|ribosomal large subunit biogenesis|roof of mouth development|regulation of signal transduction by p53 class mediator PAK2 3529.66302 3331.085488 3728.240552 1.11922692 0.162502569 0.609790059 1 27.35653131 31.93707272 5062 p21 (RAC1) activated kinase 2 "GO:0002223,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0006469,GO:0006915,GO:0007165,GO:0014069,GO:0016310,GO:0018105,GO:0019901,GO:0030296,GO:0031098,GO:0031267,GO:0031295,GO:0032147,GO:0034333,GO:0035722,GO:0038095,GO:0040008,GO:0042802,GO:0043066,GO:0045296,GO:0046777,GO:0048010,GO:0048471,GO:0050690,GO:0050731,GO:0050770,GO:0050852,GO:0051493,GO:0051497,GO:0060996,GO:0061098,GO:0070830,GO:0071407,GO:0098978,GO:0106310,GO:0106311,GO:0150105,GO:2001238,GO:2001271" stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|cell-cell junction|protein phosphorylation|negative regulation of protein kinase activity|apoptotic process|signal transduction|postsynaptic density|phosphorylation|peptidyl-serine phosphorylation|protein kinase binding|protein tyrosine kinase activator activity|stress-activated protein kinase signaling cascade|small GTPase binding|T cell costimulation|activation of protein kinase activity|adherens junction assembly|interleukin-12-mediated signaling pathway|Fc-epsilon receptor signaling pathway|regulation of growth|identical protein binding|negative regulation of apoptotic process|cadherin binding|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|perinuclear region of cytoplasm|regulation of defense response to virus by virus|positive regulation of peptidyl-tyrosine phosphorylation|regulation of axonogenesis|T cell receptor signaling pathway|regulation of cytoskeleton organization|negative regulation of stress fiber assembly|dendritic spine development|positive regulation of protein tyrosine kinase activity|bicellular tight junction assembly|cellular response to organic cyclic compound|glutamatergic synapse|protein serine kinase activity|protein threonine kinase activity|protein localization to cell-cell junction|positive regulation of extrinsic apoptotic signaling pathway|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis "hsa04010,hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05130,hsa05170,hsa05211" MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Human immunodeficiency virus 1 infection|Renal cell carcinoma PAK3 379.8731264 441.5058462 318.2404065 0.720806778 -0.472315517 0.283556093 1 1.806926349 1.358548798 5063 p21 (RAC1) activated kinase 3 "GO:0000165,GO:0000187,GO:0002223,GO:0004674,GO:0004708,GO:0005515,GO:0005524,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0007409,GO:0010763,GO:0014069,GO:0016358,GO:0017124,GO:0030833,GO:0031098,GO:0031267,GO:0031295,GO:0032147,GO:0043525,GO:0046872,GO:0048013,GO:0050770,GO:0050808,GO:0050852,GO:0060997,GO:0061003,GO:0071407,GO:0098978,GO:0106310,GO:0106311,GO:2000573" MAPK cascade|activation of MAPK activity|stimulatory C-type lectin receptor signaling pathway|protein serine/threonine kinase activity|MAP kinase kinase activity|protein binding|ATP binding|cytoplasm|endosome|cytosol|plasma membrane|protein phosphorylation|signal transduction|axonogenesis|positive regulation of fibroblast migration|postsynaptic density|dendrite development|SH3 domain binding|regulation of actin filament polymerization|stress-activated protein kinase signaling cascade|small GTPase binding|T cell costimulation|activation of protein kinase activity|positive regulation of neuron apoptotic process|metal ion binding|ephrin receptor signaling pathway|regulation of axonogenesis|synapse organization|T cell receptor signaling pathway|dendritic spine morphogenesis|positive regulation of dendritic spine morphogenesis|cellular response to organic cyclic compound|glutamatergic synapse|protein serine kinase activity|protein threonine kinase activity|positive regulation of DNA biosynthetic process "hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05130,hsa05132,hsa05170,hsa05211" ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection|Human immunodeficiency virus 1 infection|Renal cell carcinoma PAK4 1207.09663 1121.526345 1292.666915 1.152596121 0.204887069 0.549555995 1 16.09559447 19.35085259 10298 p21 (RAC1) activated kinase 4 "GO:0001558,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005912,GO:0005925,GO:0006468,GO:0006915,GO:0007010,GO:0007049,GO:0007165,GO:0016477,GO:0031098,GO:0032147,GO:0045766,GO:0060996,GO:0071407,GO:0098609,GO:0098641,GO:0106310,GO:0106311,GO:2000352" regulation of cell growth|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|Golgi apparatus|adherens junction|focal adhesion|protein phosphorylation|apoptotic process|cytoskeleton organization|cell cycle|signal transduction|cell migration|stress-activated protein kinase signaling cascade|activation of protein kinase activity|positive regulation of angiogenesis|dendritic spine development|cellular response to organic cyclic compound|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|protein serine kinase activity|protein threonine kinase activity|negative regulation of endothelial cell apoptotic process "hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05170,hsa05206,hsa05211" ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection|MicroRNAs in cancer|Renal cell carcinoma PALB2 434.4541027 400.9076075 468.0005979 1.167352749 0.223240579 0.600762939 1 4.058476115 4.941753 79728 partner and localizer of BRCA2 "GO:0000724,GO:0001756,GO:0001833,GO:0003677,GO:0005515,GO:0005654,GO:0007498,GO:0009887,GO:0035264,GO:0036342,GO:0043066,GO:0048568" double-strand break repair via homologous recombination|somitogenesis|inner cell mass cell proliferation|DNA binding|protein binding|nucleoplasm|mesoderm development|animal organ morphogenesis|multicellular organism growth|post-anal tail morphogenesis|negative regulation of apoptotic process|embryonic organ development "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway other PALD1 4.956013635 2.029911937 7.882115332 3.882983882 1.957165719 0.335178207 1 0.016864809 0.068306645 27143 phosphatase domain containing paladin 1 "GO:0004725,GO:0005515,GO:0005737,GO:0005829,GO:0035335" protein tyrosine phosphatase activity|protein binding|cytoplasm|cytosol|peptidyl-tyrosine dephosphorylation PALLD 1012.869887 1247.380885 778.3588891 0.623994562 -0.680394639 0.053471643 1 6.602094402 4.297129724 23022 "palladin, cytoskeletal associated protein" "GO:0001725,GO:0001726,GO:0002102,GO:0003334,GO:0003382,GO:0003779,GO:0005515,GO:0005634,GO:0005829,GO:0005884,GO:0005886,GO:0005925,GO:0007010,GO:0007156,GO:0007411,GO:0015629,GO:0016477,GO:0030018,GO:0030027,GO:0030036,GO:0030424,GO:0030426,GO:0051371,GO:0060076,GO:0070593,GO:0098632" stress fiber|ruffle|podosome|keratinocyte development|epithelial cell morphogenesis|actin binding|protein binding|nucleus|cytosol|actin filament|plasma membrane|focal adhesion|cytoskeleton organization|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|actin cytoskeleton|cell migration|Z disc|lamellipodium|actin cytoskeleton organization|axon|growth cone|muscle alpha-actinin binding|excitatory synapse|dendrite self-avoidance|cell-cell adhesion mediator activity PALM2AKAP2 4415.750756 4903.252283 3928.249229 0.801151767 -0.319852529 0.317024106 1 14.74395479 12.32096475 445815 PALM2 and AKAP2 fusion "GO:0005515,GO:0005886,GO:0008360" protein binding|plasma membrane|regulation of cell shape PALM3 218.4033312 146.1536594 290.6530029 1.988680981 0.991811862 0.059450742 1 2.838254314 5.887519476 342979 paralemmin 3 "GO:0001960,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0008063,GO:0032496" negative regulation of cytokine-mediated signaling pathway|protein binding|ATP binding|cytoplasm|plasma membrane|Toll signaling pathway|response to lipopolysaccharide PALS1 1119.366281 1084.98793 1153.744632 1.063370937 0.088644942 0.799669283 1 9.515291958 10.5541396 64398 "protein associated with LIN7 1, MAGUK family member" PALS2 560.4031606 591.7193296 529.0869917 0.894151949 -0.161408076 0.687141695 1 3.266677194 3.046726554 51678 "protein associated with LIN7 2, MAGUK family member" PAM 4149.566552 4151.169911 4147.963194 0.999227515 -0.001114891 0.998077391 1 43.87356251 45.72810605 5066 peptidylglycine alpha-amidating monooxygenase "GO:0001519,GO:0001666,GO:0001676,GO:0004504,GO:0004598,GO:0005507,GO:0005509,GO:0005515,GO:0005576,GO:0005802,GO:0005886,GO:0006357,GO:0007417,GO:0007507,GO:0007595,GO:0008270,GO:0009268,GO:0009404,GO:0009986,GO:0010043,GO:0016020,GO:0016021,GO:0018032,GO:0018215,GO:0019901,GO:0022602,GO:0030658,GO:0030667,GO:0031418,GO:0032355,GO:0032956,GO:0042476,GO:0042493,GO:0042802,GO:0043005,GO:0043204,GO:0046688,GO:0048471,GO:0050708,GO:0051384,GO:0055114,GO:0060135,GO:0060173,GO:0062112,GO:0070062" peptide amidation|response to hypoxia|long-chain fatty acid metabolic process|peptidylglycine monooxygenase activity|peptidylamidoglycolate lyase activity|copper ion binding|calcium ion binding|protein binding|extracellular region|trans-Golgi network|plasma membrane|regulation of transcription by RNA polymerase II|central nervous system development|heart development|lactation|zinc ion binding|response to pH|toxin metabolic process|cell surface|response to zinc ion|membrane|integral component of membrane|protein amidation|protein phosphopantetheinylation|protein kinase binding|ovulation cycle process|transport vesicle membrane|secretory granule membrane|L-ascorbic acid binding|response to estradiol|regulation of actin cytoskeleton organization|odontogenesis|response to drug|identical protein binding|neuron projection|perikaryon|response to copper ion|perinuclear region of cytoplasm|regulation of protein secretion|response to glucocorticoid|oxidation-reduction process|maternal process involved in female pregnancy|limb development|fatty acid primary amide biosynthetic process|extracellular exosome PAN2 875.5175433 849.5181455 901.5169411 1.061209753 0.085709839 0.814858842 1 7.851295101 8.690774141 9924 poly(A) specific ribonuclease subunit PAN2 "GO:0000175,GO:0000289,GO:0000932,GO:0003676,GO:0004535,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006397,GO:0006508,GO:0010606,GO:0018215,GO:0031251,GO:0046872,GO:0090503" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|P-body|nucleic acid binding|poly(A)-specific ribonuclease activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|mRNA processing|proteolysis|positive regulation of cytoplasmic mRNA processing body assembly|protein phosphopantetheinylation|PAN complex|metal ion binding|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation PAN3 927.8229105 889.1014283 966.5443926 1.087102508 0.120487985 0.737785844 1 4.070311017 4.615449706 255967 poly(A) specific ribonuclease subunit PAN3 "GO:0000289,GO:0000932,GO:0003723,GO:0004535,GO:0004672,GO:0005515,GO:0005524,GO:0005829,GO:0006397,GO:0006468,GO:0031251,GO:0046872,GO:0090503" "nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA binding|poly(A)-specific ribonuclease activity|protein kinase activity|protein binding|ATP binding|cytosol|mRNA processing|protein phosphorylation|PAN complex|metal ion binding|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation PANK1 425.0022945 428.3114187 421.6931703 0.984548046 -0.022466484 0.963988403 1 2.249555363 2.310199737 53354 pantothenate kinase 1 "GO:0004594,GO:0005524,GO:0005634,GO:0005829,GO:0015937,GO:0016310,GO:0042803,GO:1905502" pantothenate kinase activity|ATP binding|nucleus|cytosol|coenzyme A biosynthetic process|phosphorylation|protein homodimerization activity|acetyl-CoA binding hsa00770 Pantothenate and CoA biosynthesis PANK2 1417.646053 1471.686154 1363.605953 0.926560292 -0.110043239 0.74310599 1 8.518367075 8.232769665 80025 pantothenate kinase 2 "GO:0004594,GO:0005524,GO:0005634,GO:0005739,GO:0005758,GO:0005829,GO:0007286,GO:0009060,GO:0015937,GO:0015939,GO:0016310,GO:0019217,GO:0051881,GO:0070584,GO:0090207,GO:1904251" pantothenate kinase activity|ATP binding|nucleus|mitochondrion|mitochondrial intermembrane space|cytosol|spermatid development|aerobic respiration|coenzyme A biosynthetic process|pantothenate metabolic process|phosphorylation|regulation of fatty acid metabolic process|regulation of mitochondrial membrane potential|mitochondrion morphogenesis|regulation of triglyceride metabolic process|regulation of bile acid metabolic process hsa00770 Pantothenate and CoA biosynthesis PANK3 1832.492107 1778.202857 1886.781358 1.061060807 0.085507336 0.793385016 1 8.765787577 9.701684446 79646 pantothenate kinase 3 "GO:0004594,GO:0005524,GO:0005634,GO:0005829,GO:0015937,GO:0016310,GO:0019842,GO:0042803,GO:1905502" pantothenate kinase activity|ATP binding|nucleus|cytosol|coenzyme A biosynthetic process|phosphorylation|vitamin binding|protein homodimerization activity|acetyl-CoA binding hsa00770 Pantothenate and CoA biosynthesis PANK4 690.5795514 566.3454304 814.8136725 1.438722075 0.524787926 0.166184422 1 6.435584048 9.657857726 55229 pantothenate kinase 4 (inactive) "GO:0004594,GO:0005524,GO:0005634,GO:0005829,GO:0015937,GO:0016310,GO:0016787,GO:0046872" pantothenate kinase activity|ATP binding|nucleus|cytosol|coenzyme A biosynthetic process|phosphorylation|hydrolase activity|metal ion binding PANO1 11.00121212 11.16451565 10.83790858 0.970745971 -0.042834281 1 1 0.222003664 0.224792423 101927423 "GO:0005730,GO:0006915,GO:0031647,GO:0032435,GO:0043065" nucleolus|apoptotic process|regulation of protein stability|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of apoptotic process PANX1 1273.400572 1579.271487 967.529657 0.612643023 -0.706881412 0.037560602 0.879268401 11.89184203 7.599281856 24145 pannexin 1 "GO:0002020,GO:0002931,GO:0005102,GO:0005198,GO:0005262,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005921,GO:0006812,GO:0006816,GO:0007267,GO:0016020,GO:0016021,GO:0022829,GO:0022840,GO:0032059,GO:0032730,GO:0032731,GO:0032991,GO:0033198,GO:0044325,GO:0048477,GO:0051015,GO:0055077,GO:0070588,GO:0097110" protease binding|response to ischemia|signaling receptor binding|structural molecule activity|calcium channel activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|gap junction|cation transport|calcium ion transport|cell-cell signaling|membrane|integral component of membrane|wide pore channel activity|leak channel activity|bleb|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-1 beta production|protein-containing complex|response to ATP|ion channel binding|oogenesis|actin filament binding|gap junction hemi-channel activity|calcium ion transmembrane transport|scaffold protein binding hsa04621 NOD-like receptor signaling pathway PANX2 249.9560408 215.1706653 284.7414164 1.323328233 0.404170947 0.421650415 1 3.672947462 5.069886354 56666 pannexin 2 "GO:0002931,GO:0005198,GO:0005737,GO:0005886,GO:0005921,GO:0006812,GO:0007267,GO:0016021,GO:0022829,GO:0032732,GO:0055077,GO:0055085" response to ischemia|structural molecule activity|cytoplasm|plasma membrane|gap junction|cation transport|cell-cell signaling|integral component of membrane|wide pore channel activity|positive regulation of interleukin-1 production|gap junction hemi-channel activity|transmembrane transport PAOX 133.0443471 137.0190557 129.0696386 0.941983127 -0.086226877 0.900667145 1 3.792093879 3.725959533 196743 polyamine oxidase "GO:0005782,GO:0005829,GO:0006596,GO:0006625,GO:0009446,GO:0009447,GO:0016491,GO:0046203,GO:0046208,GO:0046592,GO:0052899,GO:0052901,GO:0052902,GO:0052903,GO:0052904,GO:0055114,GO:1901307" "peroxisomal matrix|cytosol|polyamine biosynthetic process|protein targeting to peroxisome|putrescine biosynthetic process|putrescine catabolic process|oxidoreductase activity|spermidine catabolic process|spermine catabolic process|polyamine oxidase activity|N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity|spermine:oxygen oxidoreductase (spermidine-forming) activity|spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity|N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity|N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity|oxidation-reduction process|positive regulation of spermidine biosynthetic process" hsa04146 Peroxisome PAPLN 225.4107835 254.7539481 196.0676189 0.769635252 -0.377753215 0.468273432 1 2.089455668 1.677389972 89932 "papilin, proteoglycan like sulfated glycoprotein" "GO:0004222,GO:0004867,GO:0006508,GO:0010951,GO:0030198,GO:0031012" metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|proteolysis|negative regulation of endopeptidase activity|extracellular matrix organization|extracellular matrix PAPOLA 4271.238297 4622.10948 3920.367113 0.848177035 -0.237562674 0.456884472 1 50.61481932 44.77959176 10914 poly(A) polymerase alpha "GO:0000287,GO:0000398,GO:0003723,GO:0004652,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006369,GO:0006378,GO:0030145,GO:0031124,GO:0031440,GO:0043631" "magnesium ion binding|mRNA splicing, via spliceosome|RNA binding|polynucleotide adenylyltransferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|termination of RNA polymerase II transcription|mRNA polyadenylation|manganese ion binding|mRNA 3'-end processing|regulation of mRNA 3'-end processing|RNA polyadenylation" hsa03015 mRNA surveillance pathway PAPOLG 375.1479642 354.219633 396.0762955 1.118165846 0.161134184 0.719190867 1 2.43485 2.839843215 64895 poly(A) polymerase gamma "GO:0003723,GO:0004652,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006378,GO:0016020,GO:0016604,GO:0043631,GO:0046872" RNA binding|polynucleotide adenylyltransferase activity|ATP binding|nucleus|nucleoplasm|cytosol|mRNA polyadenylation|membrane|nuclear body|RNA polyadenylation|metal ion binding hsa03015 mRNA surveillance pathway PAPPA 72.44118296 69.01700585 75.86536007 1.099227055 0.136489418 0.873280719 1 0.317481187 0.364016722 5069 pappalysin 1 "GO:0004222,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0007565,GO:0008237,GO:0008270,GO:0032354,GO:0044267,GO:0051384" metalloendopeptidase activity|protein binding|extracellular region|extracellular space|proteolysis|female pregnancy|metallopeptidase activity|zinc ion binding|response to follicle-stimulating hormone|cellular protein metabolic process|response to glucocorticoid PAPPA2 13.52375626 15.22433953 11.823173 0.776596776 -0.364762376 0.820851526 1 0.06871572 0.055663128 60676 pappalysin 2 "GO:0001558,GO:0005576,GO:0005829,GO:0006508,GO:0008237,GO:0008270,GO:0009651,GO:0016324,GO:0044267,GO:0060349,GO:0070062" regulation of cell growth|extracellular region|cytosol|proteolysis|metallopeptidase activity|zinc ion binding|response to salt stress|apical plasma membrane|cellular protein metabolic process|bone morphogenesis|extracellular exosome PAPSS1 1336.144496 1389.474721 1282.81427 0.923236854 -0.115227279 0.733536349 1 25.2229365 24.28984306 9061 3'-phosphoadenosine 5'-phosphosulfate synthase 1 "GO:0000103,GO:0001501,GO:0004020,GO:0004781,GO:0005524,GO:0005829,GO:0016310,GO:0016779,GO:0042803,GO:0050428" sulfate assimilation|skeletal system development|adenylylsulfate kinase activity|sulfate adenylyltransferase (ATP) activity|ATP binding|cytosol|phosphorylation|nucleotidyltransferase activity|protein homodimerization activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process "hsa00230,hsa00450,hsa00920" Purine metabolism|Selenocompound metabolism|Sulfur metabolism PAPSS2 1954.432559 2065.435396 1843.429723 0.892513863 -0.164053517 0.611875352 1 28.27980978 26.32736437 9060 3'-phosphoadenosine 5'-phosphosulfate synthase 2 "GO:0000103,GO:0001501,GO:0004020,GO:0004781,GO:0005515,GO:0005524,GO:0005829,GO:0016310,GO:0016779,GO:0050428" sulfate assimilation|skeletal system development|adenylylsulfate kinase activity|sulfate adenylyltransferase (ATP) activity|protein binding|ATP binding|cytosol|phosphorylation|nucleotidyltransferase activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process "hsa00230,hsa00450,hsa00920" Purine metabolism|Selenocompound metabolism|Sulfur metabolism PAQR3 786.8167759 813.9946866 759.6388652 0.933223371 -0.099705658 0.789380227 1 4.276995464 4.163325108 152559 progestin and adipoQ receptor family member 3 "GO:0000139,GO:0000165,GO:0001933,GO:0005515,GO:0005794,GO:0010977,GO:0016021,GO:0033137,GO:0034067,GO:0038023,GO:0043407" Golgi membrane|MAPK cascade|negative regulation of protein phosphorylation|protein binding|Golgi apparatus|negative regulation of neuron projection development|integral component of membrane|negative regulation of peptidyl-serine phosphorylation|protein localization to Golgi apparatus|signaling receptor activity|negative regulation of MAP kinase activity PAQR4 683.3330828 643.4820839 723.1840817 1.123860477 0.168462941 0.6592705 1 14.24392373 16.69775051 124222 progestin and adipoQ receptor family member 4 "GO:0016021,GO:0038023" integral component of membrane|signaling receptor activity PAQR5 43.70793295 24.35894324 63.05692266 2.588655921 1.372203218 0.124079957 1 0.249029984 0.672421978 54852 progestin and adipoQ receptor family member 5 "GO:0005496,GO:0005515,GO:0005886,GO:0007275,GO:0016021,GO:0038023,GO:0048477" steroid binding|protein binding|plasma membrane|multicellular organism development|integral component of membrane|signaling receptor activity|oogenesis PAQR6 26.13647699 35.52345889 16.74949508 0.471505186 -1.084654457 0.295603888 1 0.815565673 0.401108016 79957 progestin and adipoQ receptor family member 6 "GO:0005496,GO:0005515,GO:0005886,GO:0016021,GO:0038023" steroid binding|protein binding|plasma membrane|integral component of membrane|signaling receptor activity PAQR7 544.4216865 509.5078961 579.3354769 1.137049065 0.18529451 0.645603262 1 8.670960182 10.28400614 164091 progestin and adipoQ receptor family member 7 "GO:0003707,GO:0005496,GO:0005515,GO:0005886,GO:0007275,GO:0016021,GO:0038023,GO:0043401,GO:0048477,GO:0048545" steroid hormone receptor activity|steroid binding|protein binding|plasma membrane|multicellular organism development|integral component of membrane|signaling receptor activity|steroid hormone mediated signaling pathway|oogenesis|response to steroid hormone PAQR8 126.2514167 144.1237475 108.3790858 0.751986315 -0.411221687 0.515998015 1 1.548114395 1.214308167 85315 progestin and adipoQ receptor family member 8 "GO:0003707,GO:0005496,GO:0005515,GO:0005794,GO:0005886,GO:0007275,GO:0016021,GO:0038023,GO:0043401,GO:0048477,GO:0048545" steroid hormone receptor activity|steroid binding|protein binding|Golgi apparatus|plasma membrane|multicellular organism development|integral component of membrane|signaling receptor activity|steroid hormone mediated signaling pathway|oogenesis|response to steroid hormone PAQR9 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.018753717 0.004747324 344838 progestin and adipoQ receptor family member 9 "GO:0005496,GO:0005886,GO:0016021,GO:0038023" steroid binding|plasma membrane|integral component of membrane|signaling receptor activity PARD3 1571.350024 1438.192607 1704.507441 1.185173274 0.245097998 0.457543104 1 11.93892508 14.75920639 56288 par-3 family cell polarity regulator "GO:0000226,GO:0005515,GO:0005546,GO:0005547,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0005912,GO:0005923,GO:0005938,GO:0006612,GO:0007049,GO:0007155,GO:0007163,GO:0007179,GO:0007205,GO:0007409,GO:0008104,GO:0008356,GO:0010801,GO:0012505,GO:0016324,GO:0019903,GO:0022011,GO:0030010,GO:0030054,GO:0031643,GO:0032266,GO:0032991,GO:0033269,GO:0035091,GO:0042802,GO:0043025,GO:0043296,GO:0044295,GO:0045197,GO:0051660,GO:0060341,GO:0065003,GO:0070830,GO:0090162" "microtubule cytoskeleton organization|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|cytoskeleton|plasma membrane|cell-cell junction|adherens junction|bicellular tight junction|cell cortex|protein targeting to membrane|cell cycle|cell adhesion|establishment or maintenance of cell polarity|transforming growth factor beta receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|axonogenesis|protein localization|asymmetric cell division|negative regulation of peptidyl-threonine phosphorylation|endomembrane system|apical plasma membrane|protein phosphatase binding|myelination in peripheral nervous system|establishment of cell polarity|cell junction|positive regulation of myelination|phosphatidylinositol-3-phosphate binding|protein-containing complex|internode region of axon|phosphatidylinositol binding|identical protein binding|neuronal cell body|apical junction complex|axonal growth cone|establishment or maintenance of epithelial cell apical/basal polarity|establishment of centrosome localization|regulation of cellular localization|protein-containing complex assembly|bicellular tight junction assembly|establishment of epithelial cell polarity" "hsa04015,hsa04062,hsa04080,hsa04144,hsa04360,hsa04390,hsa04520,hsa04530,hsa05165" Rap1 signaling pathway|Chemokine signaling pathway|Neuroactive ligand-receptor interaction|Endocytosis|Axon guidance|Hippo signaling pathway|Adherens junction|Tight junction|Human papillomavirus infection PARD3B 57.62040099 32.47859099 82.76221099 2.548208173 1.349483142 0.099342227 1 0.068675938 0.182538901 117583 par-3 family cell polarity regulator beta "GO:0000226,GO:0005515,GO:0005912,GO:0005923,GO:0005938,GO:0007049,GO:0007155,GO:0008104,GO:0012505,GO:0016324,GO:0030010,GO:0030054,GO:0032991,GO:0035091,GO:0043296,GO:0045197,GO:0051301,GO:0051660" microtubule cytoskeleton organization|protein binding|adherens junction|bicellular tight junction|cell cortex|cell cycle|cell adhesion|protein localization|endomembrane system|apical plasma membrane|establishment of cell polarity|cell junction|protein-containing complex|phosphatidylinositol binding|apical junction complex|establishment or maintenance of epithelial cell apical/basal polarity|cell division|establishment of centrosome localization PARD6A 42.12339429 50.74779842 33.49899016 0.66010726 -0.59922763 0.510547727 1 2.054513959 1.414619158 50855 par-6 family cell polarity regulator alpha "GO:0001726,GO:0001933,GO:0005080,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0005886,GO:0005923,GO:0005938,GO:0007098,GO:0007163,GO:0007179,GO:0008134,GO:0016032,GO:0016324,GO:0030742,GO:0031267,GO:0034451,GO:0045217,GO:0050714,GO:0051301,GO:0060071,GO:0060341,GO:0070830,GO:1904781" "ruffle|negative regulation of protein phosphorylation|protein kinase C binding|protein binding|nucleus|centrosome|cytosol|plasma membrane|bicellular tight junction|cell cortex|centrosome cycle|establishment or maintenance of cell polarity|transforming growth factor beta receptor signaling pathway|transcription factor binding|viral process|apical plasma membrane|GTP-dependent protein binding|small GTPase binding|centriolar satellite|cell-cell junction maintenance|positive regulation of protein secretion|cell division|Wnt signaling pathway, planar cell polarity pathway|regulation of cellular localization|bicellular tight junction assembly|positive regulation of protein localization to centrosome" "hsa04015,hsa04144,hsa04360,hsa04390,hsa04530,hsa05165" Rap1 signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Human papillomavirus infection PARD6B 174.6629851 153.2583512 196.0676189 1.279327471 0.3553856 0.531625432 1 1.695128811 2.262040419 84612 par-6 family cell polarity regulator beta "GO:0005080,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005923,GO:0005938,GO:0007043,GO:0007098,GO:0007163,GO:0007409,GO:0016324,GO:0030334,GO:0032991,GO:0051301,GO:0060341,GO:0065003,GO:0070062,GO:0070830" protein kinase C binding|protein binding|nucleus|cytosol|plasma membrane|bicellular tight junction|cell cortex|cell-cell junction assembly|centrosome cycle|establishment or maintenance of cell polarity|axonogenesis|apical plasma membrane|regulation of cell migration|protein-containing complex|cell division|regulation of cellular localization|protein-containing complex assembly|extracellular exosome|bicellular tight junction assembly "hsa04015,hsa04144,hsa04360,hsa04390,hsa04530,hsa05165" Rap1 signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Human papillomavirus infection PARD6G 291.4977283 259.8287279 323.1667286 1.243768275 0.314717723 0.511762026 1 3.430502724 4.450544759 84552 par-6 family cell polarity regulator gamma "GO:0005080,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005923,GO:0005938,GO:0007098,GO:0007163,GO:0016324,GO:0032991,GO:0051301,GO:0060341,GO:0070830" protein kinase C binding|protein binding|nucleus|cytosol|plasma membrane|bicellular tight junction|cell cortex|centrosome cycle|establishment or maintenance of cell polarity|apical plasma membrane|protein-containing complex|cell division|regulation of cellular localization|bicellular tight junction assembly "hsa04015,hsa04144,hsa04360,hsa04390,hsa04530,hsa05165" Rap1 signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Human papillomavirus infection PARG 850.8859329 849.5181455 852.2537203 1.003220149 0.004638229 0.99349604 1 9.76733193 10.22087607 8505 poly(ADP-ribose) glycohydrolase "GO:0004649,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005829,GO:0005975,GO:0006282,GO:0006974,GO:0009225,GO:0031056,GO:0043231,GO:1990966" poly(ADP-ribose) glycohydrolase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|cytosol|carbohydrate metabolic process|regulation of DNA repair|cellular response to DNA damage stimulus|nucleotide-sugar metabolic process|regulation of histone modification|intracellular membrane-bounded organelle|ATP generation from poly-ADP-D-ribose PARK7 3776.005602 4107.526804 3444.4844 0.838578679 -0.253981945 0.425159591 1 206.7909962 180.8803423 11315 Parkinsonism associated deglycase "GO:0000785,GO:0001046,GO:0001933,GO:0002866,GO:0003690,GO:0003697,GO:0003713,GO:0003729,GO:0005102,GO:0005507,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005758,GO:0005759,GO:0005783,GO:0005829,GO:0005886,GO:0005912,GO:0006281,GO:0006469,GO:0006508,GO:0006517,GO:0006914,GO:0006954,GO:0007005,GO:0007265,GO:0007338,GO:0008134,GO:0008233,GO:0008344,GO:0009438,GO:0010273,GO:0010628,GO:0010629,GO:0016532,GO:0016570,GO:0016605,GO:0016684,GO:0019249,GO:0019826,GO:0019899,GO:0019900,GO:0019955,GO:0030073,GO:0030424,GO:0031334,GO:0031397,GO:0032091,GO:0032148,GO:0032435,GO:0032679,GO:0032757,GO:0033138,GO:0033182,GO:0033234,GO:0033864,GO:0034599,GO:0035065,GO:0036470,GO:0036471,GO:0036478,GO:0036524,GO:0036526,GO:0036527,GO:0036528,GO:0036529,GO:0036530,GO:0036531,GO:0042593,GO:0042743,GO:0042802,GO:0042803,GO:0043066,GO:0043523,GO:0043524,GO:0044297,GO:0044388,GO:0044390,GO:0044877,GO:0045121,GO:0045296,GO:0045340,GO:0045944,GO:0046295,GO:0046826,GO:0048471,GO:0050681,GO:0050727,GO:0050787,GO:0050821,GO:0051091,GO:0051444,GO:0051583,GO:0051881,GO:0051897,GO:0051899,GO:0051920,GO:0055114,GO:0060081,GO:0060548,GO:0060765,GO:0061727,GO:0070062,GO:0070301,GO:0070491,GO:0070994,GO:0097110,GO:0098793,GO:0098869,GO:0106044,GO:0106045,GO:0106046,GO:0110095,GO:0140041,GO:1900182,GO:1901215,GO:1901671,GO:1901984,GO:1902177,GO:1902236,GO:1902903,GO:1902958,GO:1903073,GO:1903094,GO:1903122,GO:1903135,GO:1903136,GO:1903168,GO:1903178,GO:1903181,GO:1903189,GO:1903190,GO:1903197,GO:1903200,GO:1903202,GO:1903206,GO:1903208,GO:1903377,GO:1903384,GO:1903427,GO:1903428,GO:1903599,GO:1905259,GO:1990381,GO:1990422,GO:2000157,GO:2000277,GO:2000679,GO:2000825,GO:2001237,GO:2001268" "chromatin|core promoter sequence-specific DNA binding|negative regulation of protein phosphorylation|positive regulation of acute inflammatory response to antigenic stimulus|double-stranded DNA binding|single-stranded DNA binding|transcription coactivator activity|mRNA binding|signaling receptor binding|copper ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|endoplasmic reticulum|cytosol|plasma membrane|adherens junction|DNA repair|negative regulation of protein kinase activity|proteolysis|protein deglycosylation|autophagy|inflammatory response|mitochondrion organization|Ras protein signal transduction|single fertilization|transcription factor binding|peptidase activity|adult locomotory behavior|methylglyoxal metabolic process|detoxification of copper ion|positive regulation of gene expression|negative regulation of gene expression|superoxide dismutase copper chaperone activity|histone modification|PML body|oxidoreductase activity, acting on peroxide as acceptor|lactate biosynthetic process|oxygen sensor activity|enzyme binding|kinase binding|cytokine binding|insulin secretion|axon|positive regulation of protein-containing complex assembly|negative regulation of protein ubiquitination|negative regulation of protein binding|activation of protein kinase B activity|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of TRAIL production|positive regulation of interleukin-8 production|positive regulation of peptidyl-serine phosphorylation|regulation of histone ubiquitination|negative regulation of protein sumoylation|positive regulation of NAD(P)H oxidase activity|cellular response to oxidative stress|regulation of histone acetylation|tyrosine 3-monooxygenase activator activity|cellular response to glyoxal|L-dopa decarboxylase activator activity|protein deglycase activity|peptidyl-cysteine deglycation|peptidyl-arginine deglycation|peptidyl-lysine deglycation|protein deglycation, glyoxal removal|protein deglycation, methylglyoxal removal|glutathione deglycation|glucose homeostasis|hydrogen peroxide metabolic process|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|cell body|small protein activating enzyme binding|ubiquitin-like protein conjugating enzyme binding|protein-containing complex binding|membrane raft|cadherin binding|mercury ion binding|positive regulation of transcription by RNA polymerase II|glycolate biosynthetic process|negative regulation of protein export from nucleus|perinuclear region of cytoplasm|androgen receptor binding|regulation of inflammatory response|detoxification of mercury ion|protein stabilization|positive regulation of DNA-binding transcription factor activity|negative regulation of ubiquitin-protein transferase activity|dopamine uptake involved in synaptic transmission|regulation of mitochondrial membrane potential|positive regulation of protein kinase B signaling|membrane depolarization|peroxiredoxin activity|oxidation-reduction process|membrane hyperpolarization|negative regulation of cell death|regulation of androgen receptor signaling pathway|methylglyoxal catabolic process to lactate|extracellular exosome|cellular response to hydrogen peroxide|repressing transcription factor binding|detection of oxidative stress|scaffold protein binding|presynapse|cellular oxidant detoxification|guanine deglycation|guanine deglycation, methylglyoxal removal|guanine deglycation, glyoxal removal|cellular detoxification of aldehyde|cellular detoxification of methylglyoxal|positive regulation of protein localization to nucleus|negative regulation of neuron death|positive regulation of superoxide dismutase activity|negative regulation of protein acetylation|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|regulation of supramolecular fiber organization|positive regulation of mitochondrial electron transport, NADH to ubiquinone|negative regulation of death-inducing signaling complex assembly|negative regulation of protein K48-linked deubiquitination|negative regulation of TRAIL-activated apoptotic signaling pathway|cupric ion binding|cuprous ion binding|positive regulation of pyrroline-5-carboxylate reductase activity|positive regulation of tyrosine 3-monooxygenase activity|positive regulation of dopamine biosynthetic process|glyoxal metabolic process|glyoxal catabolic process|positive regulation of L-dopa biosynthetic process|positive regulation of L-dopa decarboxylase activity|negative regulation of oxidative stress-induced cell death|negative regulation of hydrogen peroxide-induced cell death|negative regulation of hydrogen peroxide-induced neuron death|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway|negative regulation of reactive oxygen species biosynthetic process|positive regulation of reactive oxygen species biosynthetic process|positive regulation of autophagy of mitochondrion|negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|ubiquitin-specific protease binding|glyoxalase (glycolic acid-forming) activity|negative regulation of ubiquitin-specific protease activity|positive regulation of oxidative phosphorylation uncoupler activity|positive regulation of transcription regulatory region DNA binding|positive regulation of androgen receptor activity|negative regulation of extrinsic apoptotic signaling pathway|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway" "hsa05012,hsa05022" Parkinson disease|Pathways of neurodegeneration - multiple diseases PARL 777.80366 770.35158 785.25574 1.019347218 0.027645557 0.944009745 1 17.17991629 18.26665873 55486 presenilin associated rhomboid like "GO:0004175,GO:0004252,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0006508,GO:0006851,GO:0010821,GO:0016021,GO:0030162,GO:0033619,GO:1903214,GO:2000377" endopeptidase activity|serine-type endopeptidase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|proteolysis|mitochondrial calcium ion transmembrane transport|regulation of mitochondrion organization|integral component of membrane|regulation of proteolysis|membrane protein proteolysis|regulation of protein targeting to mitochondrion|regulation of reactive oxygen species metabolic process PARM1 64.96262518 62.92727004 66.99798033 1.064689129 0.09043225 0.928016575 1 0.622956261 0.691825084 25849 prostate androgen-regulated mucin-like protein 1 "GO:0000139,GO:0005515,GO:0005654,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0005886,GO:0010008,GO:0016021,GO:0043231,GO:0051973" Golgi membrane|protein binding|nucleoplasm|early endosome|late endosome|Golgi apparatus|cytosol|plasma membrane|endosome membrane|integral component of membrane|intracellular membrane-bounded organelle|positive regulation of telomerase activity PARN 627.7371506 682.0504107 573.4238904 0.840735349 -0.250276361 0.518917229 1 7.930084292 6.954293911 5073 poly(A)-specific ribonuclease "GO:0000175,GO:0000184,GO:0000289,GO:0000495,GO:0003723,GO:0003730,GO:0004518,GO:0004535,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0007292,GO:0009451,GO:0010587,GO:0016607,GO:0019901,GO:0032212,GO:0043169,GO:0043488,GO:0046872,GO:0051973,GO:0070034,GO:0071051,GO:0090503,GO:0090669,GO:0110008,GO:1904872" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|box H/ACA RNA 3'-end processing|RNA binding|mRNA 3'-UTR binding|nuclease activity|poly(A)-specific ribonuclease activity|protein binding|nucleus|nucleolus|cytoplasm|cytosol|female gamete generation|RNA modification|miRNA catabolic process|nuclear speck|protein kinase binding|positive regulation of telomere maintenance via telomerase|cation binding|regulation of mRNA stability|metal ion binding|positive regulation of telomerase activity|telomerase RNA binding|polyadenylation-dependent snoRNA 3'-end processing|RNA phosphodiester bond hydrolysis, exonucleolytic|telomerase RNA stabilization|ncRNA deadenylation|regulation of telomerase RNA localization to Cajal body" hsa03018 RNA degradation PARP1 4924.781358 5182.365175 4667.197541 0.900592178 -0.151054147 0.638015612 1 65.98001855 61.98070814 142 poly(ADP-ribose) polymerase 1 "GO:0000122,GO:0000715,GO:0000717,GO:0000723,GO:0000724,GO:0000781,GO:0003677,GO:0003723,GO:0003950,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005667,GO:0005730,GO:0005739,GO:0006281,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006302,GO:0006366,GO:0006471,GO:0006915,GO:0006974,GO:0007005,GO:0007179,GO:0008134,GO:0008270,GO:0010332,GO:0010613,GO:0010990,GO:0016020,GO:0016540,GO:0016604,GO:0018312,GO:0018424,GO:0019899,GO:0019901,GO:0023019,GO:0030225,GO:0030331,GO:0030592,GO:0032042,GO:0032869,GO:0032991,GO:0032993,GO:0033148,GO:0033683,GO:0034599,GO:0034644,GO:0035861,GO:0036211,GO:0042769,GO:0042802,GO:0042826,GO:0043504,GO:0044030,GO:0045944,GO:0047485,GO:0050790,GO:0051287,GO:0051901,GO:0060391,GO:0070212,GO:0070213,GO:0070412,GO:0070911,GO:0071294,GO:0090734,GO:0140294,GO:1900182,GO:1901216,GO:1903376,GO:1903518,GO:1903827,GO:1904044,GO:1904357,GO:1904646,GO:1904762,GO:1905168,GO:1990404,GO:1990966,GO:2000679,GO:2001170" "negative regulation of transcription by RNA polymerase II|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|telomere maintenance|double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|RNA binding|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|nuclear envelope|nucleoplasm|transcription regulator complex|nucleolus|mitochondrion|DNA repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair|transcription by RNA polymerase II|protein ADP-ribosylation|apoptotic process|cellular response to DNA damage stimulus|mitochondrion organization|transforming growth factor beta receptor signaling pathway|transcription factor binding|zinc ion binding|response to gamma radiation|positive regulation of cardiac muscle hypertrophy|regulation of SMAD protein complex assembly|membrane|protein autoprocessing|nuclear body|peptidyl-serine ADP-ribosylation|peptidyl-glutamic acid poly-ADP-ribosylation|enzyme binding|protein kinase binding|signal transduction involved in regulation of gene expression|macrophage differentiation|estrogen receptor binding|DNA ADP-ribosylation|mitochondrial DNA metabolic process|cellular response to insulin stimulus|protein-containing complex|protein-DNA complex|positive regulation of intracellular estrogen receptor signaling pathway|nucleotide-excision repair, DNA incision|cellular response to oxidative stress|cellular response to UV|site of double-strand break|protein modification process|DNA damage response, detection of DNA damage|identical protein binding|histone deacetylase binding|mitochondrial DNA repair|regulation of DNA methylation|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|regulation of catalytic activity|NAD binding|positive regulation of mitochondrial depolarization|positive regulation of SMAD protein signal transduction|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|R-SMAD binding|global genome nucleotide-excision repair|cellular response to zinc ion|site of DNA damage|NAD DNA ADP-ribosyltransferase activity|positive regulation of protein localization to nucleus|positive regulation of neuron death|regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|positive regulation of single strand break repair|regulation of cellular protein localization|response to aldosterone|negative regulation of telomere maintenance via telomere lengthening|cellular response to amyloid-beta|positive regulation of myofibroblast differentiation|positive regulation of double-strand break repair via homologous recombination|protein ADP-ribosylase activity|ATP generation from poly-ADP-D-ribose|positive regulation of transcription regulatory region DNA binding|negative regulation of ATP biosynthetic process" "hsa03410,hsa04064,hsa04210,hsa04217" Base excision repair|NF-kappa B signaling pathway|Apoptosis|Necroptosis PARP10 1091.247151 1014.955968 1167.538334 1.150333975 0.202052778 0.561535322 1 14.78824489 17.74420354 84875 poly(ADP-ribose) polymerase family member 10 "GO:0003714,GO:0003950,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0006471,GO:0010629,GO:0010847,GO:0019985,GO:0032088,GO:0034356,GO:0045071,GO:0045892,GO:0048147,GO:0070212,GO:0070213,GO:0070530,GO:0140289,GO:1900045,GO:1990404" "transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|nucleolus|cytoplasm|Golgi apparatus|cytosol|protein ADP-ribosylation|negative regulation of gene expression|regulation of chromatin assembly|translesion synthesis|negative regulation of NF-kappaB transcription factor activity|NAD biosynthesis via nicotinamide riboside salvage pathway|negative regulation of viral genome replication|negative regulation of transcription, DNA-templated|negative regulation of fibroblast proliferation|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|K63-linked polyubiquitin modification-dependent protein binding|protein mono-ADP-ribosylation|negative regulation of protein K63-linked ubiquitination|protein ADP-ribosylase activity" PARP11 177.574241 150.2134833 204.9349986 1.364291634 0.448152071 0.425850269 1 1.444150154 2.055112007 57097 poly(ADP-ribose) polymerase family member 11 "GO:0003950,GO:0005635,GO:0005643,GO:0005654,GO:0005829,GO:0006998,GO:0007283,GO:0015031,GO:0016604,GO:0030154,GO:0051028,GO:0070213,GO:0140289,GO:1990404" NAD+ ADP-ribosyltransferase activity|nuclear envelope|nuclear pore|nucleoplasm|cytosol|nuclear envelope organization|spermatogenesis|protein transport|nuclear body|cell differentiation|mRNA transport|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|protein ADP-ribosylase activity PARP12 720.9134236 754.1122845 687.7145627 0.911952473 -0.132969456 0.725487801 1 9.301784428 8.8481893 64761 poly(ADP-ribose) polymerase family member 12 "GO:0003723,GO:0003950,GO:0005634,GO:0046872,GO:0070213,GO:0140289,GO:1990404" RNA binding|NAD+ ADP-ribosyltransferase activity|nucleus|metal ion binding|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|protein ADP-ribosylase activity PARP14 1972.543907 2023.822201 1921.265612 0.949325297 -0.075025567 0.817293605 1 12.41966011 12.29817572 54625 poly(ADP-ribose) polymerase family member 14 "GO:0003714,GO:0003950,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006471,GO:0010629,GO:0016020,GO:0019899,GO:0042531,GO:0042532,GO:0045087,GO:0045892,GO:0060336,GO:0070212,GO:0140289,GO:1902216,GO:1990404" "transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein ADP-ribosylation|negative regulation of gene expression|membrane|enzyme binding|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|innate immune response|negative regulation of transcription, DNA-templated|negative regulation of interferon-gamma-mediated signaling pathway|protein poly-ADP-ribosylation|protein mono-ADP-ribosylation|positive regulation of interleukin-4-mediated signaling pathway|protein ADP-ribosylase activity" PARP15 9.508469716 10.14955968 8.867379749 0.873671373 -0.194837375 0.972452314 1 0.060840264 0.055444073 165631 poly(ADP-ribose) polymerase family member 15 "GO:0000122,GO:0003714,GO:0003950,GO:0005515,GO:0005634,GO:0005737,GO:0010629,GO:0070212,GO:0070403,GO:0140289,GO:1990404" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|cytoplasm|negative regulation of gene expression|protein poly-ADP-ribosylation|NAD+ binding|protein mono-ADP-ribosylation|protein ADP-ribosylase activity PARP16 171.6153956 180.6621624 162.5686287 0.899848793 -0.152245498 0.796270339 1 2.692731367 2.527426284 54956 poly(ADP-ribose) polymerase family member 16 "GO:0003950,GO:0005515,GO:0005622,GO:0005635,GO:0005783,GO:0005789,GO:0005829,GO:0006471,GO:0016020,GO:0016021,GO:0019900,GO:0030968,GO:0034356,GO:0036498,GO:0043539,GO:0060548,GO:0070213,GO:0071782,GO:0071902,GO:0140289,GO:1990404,GO:1990830" NAD+ ADP-ribosyltransferase activity|protein binding|intracellular anatomical structure|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein ADP-ribosylation|membrane|integral component of membrane|kinase binding|endoplasmic reticulum unfolded protein response|NAD biosynthesis via nicotinamide riboside salvage pathway|IRE1-mediated unfolded protein response|protein serine/threonine kinase activator activity|negative regulation of cell death|protein auto-ADP-ribosylation|endoplasmic reticulum tubular network|positive regulation of protein serine/threonine kinase activity|protein mono-ADP-ribosylation|protein ADP-ribosylase activity|cellular response to leukemia inhibitory factor PARP2 946.3323719 908.3855917 984.2791521 1.083547737 0.115762714 0.746919412 1 19.00310848 21.47774227 10038 poly(ADP-ribose) polymerase 2 "GO:0003677,GO:0003950,GO:0005515,GO:0005654,GO:0005730,GO:0006281,GO:0006284,GO:0006302,GO:0006471,GO:0018312,GO:0030592,GO:0061051,GO:0070212,GO:0097191,GO:0140294,GO:1901215,GO:1990404" DNA binding|NAD+ ADP-ribosyltransferase activity|protein binding|nucleoplasm|nucleolus|DNA repair|base-excision repair|double-strand break repair|protein ADP-ribosylation|peptidyl-serine ADP-ribosylation|DNA ADP-ribosylation|positive regulation of cell growth involved in cardiac muscle cell development|protein poly-ADP-ribosylation|extrinsic apoptotic signaling pathway|NAD DNA ADP-ribosyltransferase activity|negative regulation of neuron death|protein ADP-ribosylase activity "hsa03410,hsa04210" Base excision repair|Apoptosis PARP3 954.6180448 902.2958559 1006.940234 1.115975683 0.158305591 0.657377845 1 18.04822354 21.00898748 10039 poly(ADP-ribose) polymerase family member 3 "GO:0000723,GO:0003824,GO:0003950,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0006281,GO:0006302,GO:0006471,GO:0016604,GO:0030592,GO:0035861,GO:0045171,GO:0045829,GO:0051106,GO:0060236,GO:0070212,GO:0070213,GO:0140289,GO:0140294,GO:1905662,GO:1990166,GO:1990404,GO:2001034" telomere maintenance|catalytic activity|NAD+ ADP-ribosyltransferase activity|protein binding|nucleoplasm|nucleolus|cytoplasm|centriole|DNA repair|double-strand break repair|protein ADP-ribosylation|nuclear body|DNA ADP-ribosylation|site of double-strand break|intercellular bridge|negative regulation of isotype switching|positive regulation of DNA ligation|regulation of mitotic spindle organization|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|NAD DNA ADP-ribosyltransferase activity|negative regulation of telomerase RNA reverse transcriptase activity|protein localization to site of double-strand break|protein ADP-ribosylase activity|positive regulation of double-strand break repair via nonhomologous end joining "hsa03410,hsa04210" Base excision repair|Apoptosis PARP4 2653.48286 2368.90723 2938.05849 1.240258991 0.310641415 0.329774564 1 20.82930455 26.94654465 143 poly(ADP-ribose) polymerase family member 4 "GO:0003677,GO:0003950,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005876,GO:0006281,GO:0006464,GO:0006471,GO:0006954,GO:0006974,GO:0008219,GO:0016020,GO:0019899,GO:0042493,GO:0051972,GO:0070062,GO:0140289,GO:1990404,GO:1990904" DNA binding|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|spindle microtubule|DNA repair|cellular protein modification process|protein ADP-ribosylation|inflammatory response|cellular response to DNA damage stimulus|cell death|membrane|enzyme binding|response to drug|regulation of telomerase activity|extracellular exosome|protein mono-ADP-ribosylation|protein ADP-ribosylase activity|ribonucleoprotein complex "hsa03410,hsa04210" Base excision repair|Apoptosis PARP6 1702.755892 1530.5536 1874.958185 1.225019617 0.292804852 0.370421249 1 25.57477413 32.67915211 56965 poly(ADP-ribose) polymerase family member 6 "GO:0003950,GO:0005622,GO:0006471,GO:0050775,GO:0070213,GO:0140289,GO:1990404" NAD+ ADP-ribosyltransferase activity|intracellular anatomical structure|protein ADP-ribosylation|positive regulation of dendrite morphogenesis|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|protein ADP-ribosylase activity PARP8 958.6778687 910.4155036 1006.940234 1.106022722 0.145381025 0.683777 1 5.268433901 6.078011461 79668 poly(ADP-ribose) polymerase family member 8 "GO:0003950,GO:0005622,GO:0006471,GO:0070213,GO:0140289,GO:1990404" NAD+ ADP-ribosyltransferase activity|intracellular anatomical structure|protein ADP-ribosylation|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|protein ADP-ribosylase activity PARP9 573.8405638 567.3603863 580.3207413 1.02284325 0.03258507 0.938872846 1 3.51840358 3.753795999 83666 poly(ADP-ribose) polymerase family member 9 "GO:0000122,GO:0002230,GO:0003714,GO:0003950,GO:0004857,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006302,GO:0006471,GO:0010608,GO:0010629,GO:0016020,GO:0016477,GO:0019899,GO:0032991,GO:0034356,GO:0035563,GO:0042393,GO:0042531,GO:0043086,GO:0044389,GO:0045087,GO:0045893,GO:0051607,GO:0060330,GO:0060335,GO:0070212,GO:0070403,GO:0072570,GO:0090734,GO:0097677,GO:0140289,GO:1900182,GO:1990404,GO:2001034" "negative regulation of transcription by RNA polymerase II|positive regulation of defense response to virus by host|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|enzyme inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|double-strand break repair|protein ADP-ribosylation|posttranscriptional regulation of gene expression|negative regulation of gene expression|membrane|cell migration|enzyme binding|protein-containing complex|NAD biosynthesis via nicotinamide riboside salvage pathway|positive regulation of chromatin binding|histone binding|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of catalytic activity|ubiquitin-like protein ligase binding|innate immune response|positive regulation of transcription, DNA-templated|defense response to virus|regulation of response to interferon-gamma|positive regulation of interferon-gamma-mediated signaling pathway|protein poly-ADP-ribosylation|NAD+ binding|ADP-D-ribose binding|site of DNA damage|STAT family protein binding|protein mono-ADP-ribosylation|positive regulation of protein localization to nucleus|protein ADP-ribosylase activity|positive regulation of double-strand break repair via nonhomologous end joining" PARPBP 523.7459796 510.5228521 536.969107 1.051802294 0.072863549 0.861110888 1 6.544211957 7.179718228 55010 PARP1 binding protein "GO:0000785,GO:0003677,GO:0005515,GO:0005654,GO:0005737,GO:0006281,GO:2000042" chromatin|DNA binding|protein binding|nucleoplasm|cytoplasm|DNA repair|negative regulation of double-strand break repair via homologous recombination PARS2 164.8251867 154.2733072 175.3770661 1.136794623 0.184971636 0.754920362 1 3.316383177 3.932444881 25973 "prolyl-tRNA synthetase 2, mitochondrial" "GO:0004827,GO:0005524,GO:0005739,GO:0005759,GO:0006433" proline-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|prolyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis PARVA 3103.257304 2537.389921 3669.124687 1.446023198 0.532090697 0.094897846 1 14.4053187 21.72771524 55742 parvin alpha "GO:0002040,GO:0003148,GO:0003779,GO:0004860,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006469,GO:0007163,GO:0008360,GO:0015629,GO:0030018,GO:0030027,GO:0030031,GO:0031532,GO:0034113,GO:0034446,GO:0045296,GO:0050821,GO:0060271,GO:0070252,GO:0071670" sprouting angiogenesis|outflow tract septum morphogenesis|actin binding|protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|negative regulation of protein kinase activity|establishment or maintenance of cell polarity|regulation of cell shape|actin cytoskeleton|Z disc|lamellipodium|cell projection assembly|actin cytoskeleton reorganization|heterotypic cell-cell adhesion|substrate adhesion-dependent cell spreading|cadherin binding|protein stabilization|cilium assembly|actin-mediated cell contraction|smooth muscle cell chemotaxis hsa04510 Focal adhesion PARVB 1282.836297 1382.370029 1183.302564 0.855995529 -0.224324834 0.50823409 1 26.13369364 23.33394778 29780 parvin beta "GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0007163,GO:0015629,GO:0030018,GO:0030027,GO:0030031,GO:0030032,GO:0031532,GO:0034446,GO:0071963" actin binding|protein binding|cytoplasm|cytosol|plasma membrane|focal adhesion|establishment or maintenance of cell polarity|actin cytoskeleton|Z disc|lamellipodium|cell projection assembly|lamellipodium assembly|actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading|establishment or maintenance of cell polarity regulating cell shape hsa04510 Focal adhesion PARVG 86.17278009 98.45072893 73.89483124 0.750576781 -0.413928433 0.567282294 1 0.841265751 0.658634179 64098 parvin gamma "GO:0003779,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0005925,GO:0007160,GO:0007163,GO:0015629,GO:0030031,GO:0031532,GO:0034446" actin binding|protein binding|cytoplasm|cytoskeleton|plasma membrane|focal adhesion|cell-matrix adhesion|establishment or maintenance of cell polarity|actin cytoskeleton|cell projection assembly|actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading hsa04510 Focal adhesion PASK 404.3050608 326.8158218 481.7942997 1.47420739 0.559939496 0.195580988 1 2.260285189 3.475663738 23178 PAS domain containing serine/threonine kinase "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0035091,GO:0035556,GO:0043576,GO:0045719,GO:0045727,GO:0046777,GO:0070092,GO:0097009,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|phosphatidylinositol binding|intracellular signal transduction|regulation of respiratory gaseous exchange|negative regulation of glycogen biosynthetic process|positive regulation of translation|protein autophosphorylation|regulation of glucagon secretion|energy homeostasis|protein serine kinase activity|protein threonine kinase activity PATJ 646.4613799 446.5806261 846.3421338 1.895160883 0.922320326 0.016981323 0.570200991 2.402563551 4.749379767 10207 PATJ crumbs cell polarity complex component "GO:0005515,GO:0005829,GO:0005886,GO:0005923,GO:0016324,GO:0030054,GO:0034451,GO:0035089,GO:0035556,GO:0048471,GO:0070062,GO:0070830,GO:0120192" protein binding|cytosol|plasma membrane|bicellular tight junction|apical plasma membrane|cell junction|centriolar satellite|establishment of apical/basal cell polarity|intracellular signal transduction|perinuclear region of cytoplasm|extracellular exosome|bicellular tight junction assembly|tight junction assembly "hsa04390,hsa04530,hsa05165" Hippo signaling pathway|Tight junction|Human papillomavirus infection PATL1 2925.184742 2824.62246 3025.747023 1.071204052 0.099233322 0.755817623 1 34.64692733 38.71264646 219988 "PAT1 homolog 1, processing body mRNA decay factor" "GO:0000290,GO:0000932,GO:0003723,GO:0005515,GO:0005829,GO:0008266,GO:0016605,GO:0016607,GO:0030014,GO:0033962,GO:0034046,GO:0036464,GO:0043928" deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|RNA binding|protein binding|cytosol|poly(U) RNA binding|PML body|nuclear speck|CCR4-NOT complex|P-body assembly|poly(G) binding|cytoplasmic ribonucleoprotein granule|exonucleolytic catabolism of deadenylated mRNA hsa03018 RNA degradation PATL2 7.000771347 7.104691779 6.896850916 0.970745971 -0.042834281 1 1 0.130656345 0.13229762 197135 PAT1 homolog 2 "GO:0000290,GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0010607,GO:0017148,GO:0033962,GO:1990904" deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|RNA binding|protein binding|nucleus|cytoplasm|negative regulation of cytoplasmic mRNA processing body assembly|negative regulation of translation|P-body assembly|ribonucleoprotein complex PATZ1 1160.914649 1231.14159 1090.687709 0.885915737 -0.17475861 0.612266844 1 12.72509761 11.75897505 23598 POZ/BTB and AT hook containing zinc finger 1 "GO:0000122,GO:0000978,GO:0001227,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0007283,GO:0008584,GO:0010596,GO:0030217,GO:0031625,GO:0045892,GO:0045893,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|chromatin binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spermatogenesis|male gonad development|negative regulation of endothelial cell migration|T cell differentiation|ubiquitin protein ligase binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding" ZBTB PAWR 1061.404427 1029.165352 1093.643502 1.062650914 0.087667743 0.803665424 1 4.938752549 5.474239787 5074 pro-apoptotic WT1 regulator "GO:0000122,GO:0000785,GO:0003714,GO:0003779,GO:0005515,GO:0005634,GO:0005737,GO:0005884,GO:0005886,GO:0006915,GO:0010628,GO:0015629,GO:0019899,GO:0030889,GO:0042130,GO:0042986,GO:0043065,GO:0043522,GO:0048147,GO:0050860,GO:0051017,GO:0097190,GO:1901300,GO:2000774" negative regulation of transcription by RNA polymerase II|chromatin|transcription corepressor activity|actin binding|protein binding|nucleus|cytoplasm|actin filament|plasma membrane|apoptotic process|positive regulation of gene expression|actin cytoskeleton|enzyme binding|negative regulation of B cell proliferation|negative regulation of T cell proliferation|positive regulation of amyloid precursor protein biosynthetic process|positive regulation of apoptotic process|leucine zipper domain binding|negative regulation of fibroblast proliferation|negative regulation of T cell receptor signaling pathway|actin filament bundle assembly|apoptotic signaling pathway|positive regulation of hydrogen peroxide-mediated programmed cell death|positive regulation of cellular senescence PAX5 171.1430523 114.6900244 227.5960802 1.984445303 0.988735798 0.082544172 1 0.667353531 1.381373198 5079 paired box 5 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0006959,GO:0007275,GO:0007283,GO:0007568,GO:0009887,GO:0021670,GO:0021987,GO:0030534,GO:0035914,GO:0043231,GO:0045944,GO:0048701,GO:0048856,GO:0050855,GO:0051573" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|humoral immune response|multicellular organism development|spermatogenesis|aging|animal organ morphogenesis|lateral ventricle development|cerebral cortex development|adult behavior|skeletal muscle cell differentiation|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|embryonic cranial skeleton morphogenesis|anatomical structure development|regulation of B cell receptor signaling pathway|negative regulation of histone H3-K9 methylation" hsa05202 Transcriptional misregulation in cancer PAX PAX6 503.8976767 433.3861985 574.4091548 1.325397894 0.406425532 0.319372642 1 3.802751569 5.257268528 5080 paired box 6 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001568,GO:0001654,GO:0003322,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007417,GO:0007601,GO:0008134,GO:0009611,GO:0009887,GO:0010628,GO:0019901,GO:0021517,GO:0035035,GO:0042593,GO:0045893,GO:0045944,GO:0048663,GO:0048856,GO:0050768,GO:0061072,GO:0061303,GO:0070412,GO:1904798,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|blood vessel development|eye development|pancreatic A cell development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|central nervous system development|visual perception|transcription factor binding|response to wounding|animal organ morphogenesis|positive regulation of gene expression|protein kinase binding|ventral spinal cord development|histone acetyltransferase binding|glucose homeostasis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|neuron fate commitment|anatomical structure development|negative regulation of neurogenesis|iris morphogenesis|cornea development in camera-type eye|R-SMAD binding|positive regulation of core promoter binding|sequence-specific double-stranded DNA binding" "hsa04550,hsa04950" Signaling pathways regulating pluripotency of stem cells|Maturity onset diabetes of the young PAX PAX8 6388.706139 7190.963036 5586.449242 0.776870805 -0.364253399 0.263576334 1 89.81428103 72.77967774 7849 paired box 8 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001655,GO:0001658,GO:0001822,GO:0001823,GO:0003337,GO:0003677,GO:0003700,GO:0004996,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0007417,GO:0009653,GO:0030878,GO:0038194,GO:0039003,GO:0042472,GO:0042981,GO:0045893,GO:0045944,GO:0048793,GO:0048856,GO:0071371,GO:0071599,GO:0072108,GO:0072207,GO:0072221,GO:0072278,GO:0072284,GO:0072289,GO:0072305,GO:0072307,GO:0090190,GO:1900212,GO:1900215,GO:1900218,GO:1990837,GO:2000594,GO:2000611,GO:2000612" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|urogenital system development|branching involved in ureteric bud morphogenesis|kidney development|mesonephros development|mesenchymal to epithelial transition involved in metanephros morphogenesis|DNA binding|DNA-binding transcription factor activity|thyroid-stimulating hormone receptor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|central nervous system development|anatomical structure morphogenesis|thyroid gland development|thyroid-stimulating hormone signaling pathway|pronephric field specification|inner ear morphogenesis|regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|pronephros development|anatomical structure development|cellular response to gonadotropin stimulus|otic vesicle development|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|metanephric epithelium development|metanephric distal convoluted tubule development|metanephric comma-shaped body morphogenesis|metanephric S-shaped body morphogenesis|metanephric nephron tubule formation|negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis|regulation of metanephric nephron tubule epithelial cell differentiation|positive regulation of branching involved in ureteric bud morphogenesis|negative regulation of mesenchymal cell apoptotic process involved in metanephros development|negative regulation of apoptotic process involved in metanephric collecting duct development|negative regulation of apoptotic process involved in metanephric nephron tubule development|sequence-specific double-stranded DNA binding|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|regulation of thyroid-stimulating hormone secretion" "hsa04918,hsa05200,hsa05202,hsa05216" Thyroid hormone synthesis|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer PAX9 168.6771697 148.1835714 189.170768 1.276597441 0.352303661 0.540111755 1 1.609818775 2.143615494 5083 paired box 9 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0007492,GO:0042476,GO:0042481,GO:0045892,GO:0045944,GO:0048856,GO:0060325,GO:0071363,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|endoderm development|odontogenesis|regulation of odontogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|anatomical structure development|face morphogenesis|cellular response to growth factor stimulus|sequence-specific double-stranded DNA binding" PAXBP1 869.9446881 906.3556798 833.5336964 0.919654077 -0.120836793 0.740209315 1 10.24865321 9.831215784 94104 PAX3 and PAX7 binding protein 1 "GO:0003677,GO:0005634,GO:0005829,GO:0007517,GO:0008134,GO:0014842,GO:0031062,GO:0045944,GO:2000288" DNA binding|nucleus|cytosol|muscle organ development|transcription factor binding|regulation of skeletal muscle satellite cell proliferation|positive regulation of histone methylation|positive regulation of transcription by RNA polymerase II|positive regulation of myoblast proliferation PAXIP1 616.2608736 638.4073041 594.1144432 0.930619746 -0.103736296 0.792695658 1 5.912063958 5.738882285 22976 PAX interacting protein 1 "GO:0000416,GO:0001570,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006303,GO:0006310,GO:0010212,GO:0016363,GO:0030330,GO:0031398,GO:0035066,GO:0035097,GO:0043433,GO:0043542,GO:0044666,GO:0045830,GO:0048304,GO:0051568,GO:0051571,GO:0060261,GO:0060612,GO:0060717,GO:1902749,GO:2001022" "positive regulation of histone H3-K36 methylation|vasculogenesis|protein binding|nucleus|nucleoplasm|chromosome|double-strand break repair via nonhomologous end joining|DNA recombination|response to ionizing radiation|nuclear matrix|DNA damage response, signal transduction by p53 class mediator|positive regulation of protein ubiquitination|positive regulation of histone acetylation|histone methyltransferase complex|negative regulation of DNA-binding transcription factor activity|endothelial cell migration|MLL3/4 complex|positive regulation of isotype switching|positive regulation of isotype switching to IgG isotypes|histone H3-K4 methylation|positive regulation of histone H3-K4 methylation|positive regulation of transcription initiation from RNA polymerase II promoter|adipose tissue development|chorion development|regulation of cell cycle G2/M phase transition|positive regulation of response to DNA damage stimulus" PAXX 395.3728547 389.7430919 401.0026175 1.028889609 0.041088202 0.93076361 1 24.42959489 26.21808556 286257 PAXX non-homologous end joining factor "GO:0005515,GO:0005634,GO:0005654,GO:0006303,GO:0006974,GO:0035861,GO:0042803,GO:0043564,GO:0051103,GO:0060090,GO:0070419" protein binding|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|cellular response to DNA damage stimulus|site of double-strand break|protein homodimerization activity|Ku70:Ku80 complex|DNA ligation involved in DNA repair|molecular adaptor activity|nonhomologous end joining complex PBDC1 393.5629078 434.4011545 352.7246611 0.811979106 -0.30048549 0.491912113 1 18.56614852 15.72470853 51260 polysaccharide biosynthesis domain containing 1 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process PBK 784.6789842 667.8410272 901.5169411 1.349897512 0.432849878 0.240705469 1 18.42254468 25.93978338 55872 PDZ binding kinase "GO:0000165,GO:0000187,GO:0000278,GO:0001933,GO:0004674,GO:0004708,GO:0005515,GO:0005524,GO:0005634,GO:0006468,GO:0032435,GO:0032873,GO:0034644,GO:0050728" MAPK cascade|activation of MAPK activity|mitotic cell cycle|negative regulation of protein phosphorylation|protein serine/threonine kinase activity|MAP kinase kinase activity|protein binding|ATP binding|nucleus|protein phosphorylation|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of stress-activated MAPK cascade|cellular response to UV|negative regulation of inflammatory response PBLD 53.55785551 57.8524902 49.26322083 0.851531553 -0.231868106 0.79763033 1 0.994577236 0.883395514 64081 phenazine biosynthesis like protein domain containing "GO:0003674,GO:0005515,GO:0005737,GO:0009058,GO:0010633,GO:0010719,GO:0016853,GO:0030277,GO:0030512,GO:0042802,GO:0050680,GO:0060392,GO:0060394,GO:0070062" molecular_function|protein binding|cytoplasm|biosynthetic process|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|isomerase activity|maintenance of gastrointestinal epithelium|negative regulation of transforming growth factor beta receptor signaling pathway|identical protein binding|negative regulation of epithelial cell proliferation|negative regulation of SMAD protein signal transduction|negative regulation of pathway-restricted SMAD protein phosphorylation|extracellular exosome PBRM1 2059.526523 2076.599911 2042.453136 0.983556401 -0.02392031 0.942271267 1 11.78667037 12.09222827 55193 polybromo 1 "GO:0000228,GO:0000278,GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0006338,GO:0008285,GO:0016586,GO:0043044" nuclear chromosome|mitotic cell cycle|DNA binding|chromatin binding|protein binding|nucleoplasm|chromatin remodeling|negative regulation of cell population proliferation|RSC-type complex|ATP-dependent chromatin remodeling hsa05225 Hepatocellular carcinoma PBX1 10.44919681 7.104691779 13.79370183 1.941491941 0.957165719 0.512511229 1 0.041099666 0.083231901 5087 PBX homeobox 1 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0001658,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006694,GO:0007221,GO:0007420,GO:0007548,GO:0008284,GO:0009887,GO:0009952,GO:0009954,GO:0010971,GO:0030278,GO:0030325,GO:0030326,GO:0035019,GO:0035162,GO:0045665,GO:0048536,GO:0048538,GO:0048568,GO:0048666,GO:0048706,GO:0090575,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|branching involved in ureteric bud morphogenesis|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|steroid biosynthetic process|positive regulation of transcription of Notch receptor target|brain development|sex differentiation|positive regulation of cell population proliferation|animal organ morphogenesis|anterior/posterior pattern specification|proximal/distal pattern formation|positive regulation of G2/M transition of mitotic cell cycle|regulation of ossification|adrenal gland development|embryonic limb morphogenesis|somatic stem cell population maintenance|embryonic hemopoiesis|negative regulation of neuron differentiation|spleen development|thymus development|embryonic organ development|neuron development|embryonic skeletal system development|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa04927,hsa04934,hsa05202" Cortisol synthesis and secretion|Cushing syndrome|Transcriptional misregulation in cancer Homeobox PBX2 1361.086629 1242.306105 1479.867154 1.191225856 0.252446974 0.452551379 1 19.48542014 24.21139513 5089 PBX homeobox 2 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0003682,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007420,GO:0008134,GO:0009887,GO:0009954,GO:0030326,GO:0045944,GO:0048568,GO:0048666" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|chromatin binding|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|brain development|transcription factor binding|animal organ morphogenesis|proximal/distal pattern formation|embryonic limb morphogenesis|positive regulation of transcription by RNA polymerase II|embryonic organ development|neuron development" Homeobox PBX3 625.7802298 514.582676 736.9777836 1.432185377 0.518218242 0.181002721 1 9.058671254 13.53255073 5090 PBX homeobox 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001654,GO:0005634,GO:0006357,GO:0007387,GO:0007388,GO:0007420,GO:0009887,GO:0048568,GO:0048666" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|eye development|nucleus|regulation of transcription by RNA polymerase II|anterior compartment pattern formation|posterior compartment specification|brain development|animal organ morphogenesis|embryonic organ development|neuron development" hsa05202 Transcriptional misregulation in cancer Homeobox PBX4 37.85572955 28.41876711 47.29269199 1.664135949 0.734773297 0.432013437 1 0.818720307 1.421151227 80714 PBX homeobox 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001654,GO:0001741,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0009887,GO:0043565,GO:0045893,GO:0048568,GO:0048666" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|eye development|XY body|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|animal organ morphogenesis|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|embryonic organ development|neuron development" PBXIP1 1762.03902 1676.70726 1847.370781 1.101784924 0.139842628 0.668482498 1 26.47936004 30.4312814 57326 PBX homeobox interacting protein 1 "GO:0003714,GO:0005515,GO:0005634,GO:0005829,GO:0005874,GO:0007275,GO:0016020,GO:0030154,GO:0045892,GO:2001106" "transcription corepressor activity|protein binding|nucleus|cytosol|microtubule|multicellular organism development|membrane|cell differentiation|negative regulation of transcription, DNA-templated|regulation of Rho guanyl-nucleotide exchange factor activity" PC 314.558162 489.2087768 139.9075471 0.285987402 -1.805976498 0.000164615 0.023991359 3.911081092 1.166701223 5091 pyruvate carboxylase "GO:0004736,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006090,GO:0006094,GO:0006629,GO:0006768,GO:0009374,GO:0010629,GO:0019074,GO:0042802,GO:0044791,GO:0044794,GO:0046872" pyruvate carboxylase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|pyruvate metabolic process|gluconeogenesis|lipid metabolic process|biotin metabolic process|biotin binding|negative regulation of gene expression|viral RNA genome packaging|identical protein binding|positive regulation by host of viral release from host cell|positive regulation by host of viral process|metal ion binding "hsa00020,hsa00620" Citrate cycle (TCA cycle)|Pyruvate metabolism PCBD1 1048.82412 977.4025975 1120.245642 1.146145554 0.19679027 0.574398552 1 48.43639285 57.9065241 5092 pterin-4 alpha-carbinolamine dehydratase 1 "GO:0003713,GO:0004505,GO:0005515,GO:0005654,GO:0005829,GO:0006559,GO:0006729,GO:0008124,GO:0042802,GO:0043393,GO:0045893,GO:0055114,GO:0070062" "transcription coactivator activity|phenylalanine 4-monooxygenase activity|protein binding|nucleoplasm|cytosol|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process|4-alpha-hydroxytetrahydrobiopterin dehydratase activity|identical protein binding|regulation of protein binding|positive regulation of transcription, DNA-templated|oxidation-reduction process|extracellular exosome" hsa00790 Folate biosynthesis PCBD2 271.6857979 286.2175831 257.1540127 0.898456377 -0.154479637 0.756976855 1 6.129349204 5.744170075 84105 pterin-4 alpha-carbinolamine dehydratase 2 "GO:0004505,GO:0005515,GO:0005575,GO:0005634,GO:0006729,GO:0008124,GO:0042802,GO:0045893,GO:0055114" "phenylalanine 4-monooxygenase activity|protein binding|cellular_component|nucleus|tetrahydrobiopterin biosynthetic process|4-alpha-hydroxytetrahydrobiopterin dehydratase activity|identical protein binding|positive regulation of transcription, DNA-templated|oxidation-reduction process" hsa00790 Folate biosynthesis PCBP1 3868.349274 3954.268453 3782.430095 0.956543578 -0.064097398 0.841139372 1 115.9639533 115.7027556 5093 poly(rC) binding protein 1 "GO:0000398,GO:0000981,GO:0003697,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0010468,GO:0016020,GO:0016070,GO:0016607,GO:0036464,GO:0039694,GO:0045296,GO:0045944,GO:0051252,GO:0070062,GO:0098847" "mRNA splicing, via spliceosome|DNA-binding transcription factor activity, RNA polymerase II-specific|single-stranded DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of gene expression|membrane|RNA metabolic process|nuclear speck|cytoplasmic ribonucleoprotein granule|viral RNA genome replication|cadherin binding|positive regulation of transcription by RNA polymerase II|regulation of RNA metabolic process|extracellular exosome|sequence-specific single stranded DNA binding" "hsa03040,hsa04216" Spliceosome|Ferroptosis PCBP2 11789.65227 10371.83504 13207.4695 1.273397567 0.348682913 0.307640853 1 165.6565295 220.0333466 5094 poly(rC) binding protein 2 "GO:0000398,GO:0003697,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005925,GO:0010468,GO:0014069,GO:0016020,GO:0016070,GO:0016071,GO:0019899,GO:0031625,GO:0032480,GO:0039694,GO:0043161,GO:0045087,GO:0045944,GO:0050687,GO:0051252,GO:0051607,GO:0070062,GO:0075522,GO:1990829" "mRNA splicing, via spliceosome|single-stranded DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|focal adhesion|regulation of gene expression|postsynaptic density|membrane|RNA metabolic process|mRNA metabolic process|enzyme binding|ubiquitin protein ligase binding|negative regulation of type I interferon production|viral RNA genome replication|proteasome-mediated ubiquitin-dependent protein catabolic process|innate immune response|positive regulation of transcription by RNA polymerase II|negative regulation of defense response to virus|regulation of RNA metabolic process|defense response to virus|extracellular exosome|IRES-dependent viral translational initiation|C-rich single-stranded DNA binding" hsa04216 Ferroptosis PCBP4 905.7786705 830.2339821 981.3233589 1.181984091 0.241210618 0.502060196 1 17.26834592 21.29012938 57060 poly(rC) binding protein 4 "GO:0003677,GO:0003723,GO:0003729,GO:0003730,GO:0005634,GO:0005737,GO:0005829,GO:0006977,GO:0010468,GO:0043488,GO:0048025,GO:0051252" "DNA binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|regulation of gene expression|regulation of mRNA stability|negative regulation of mRNA splicing, via spliceosome|regulation of RNA metabolic process" PCCA 279.9120877 276.0680234 283.756152 1.027848675 0.039627879 0.942447864 1 2.67851944 2.871705584 5095 propionyl-CoA carboxylase subunit alpha "GO:0004658,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006768,GO:0009374,GO:0016421,GO:0019626,GO:0019899,GO:0046872" propionyl-CoA carboxylase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|biotin metabolic process|biotin binding|CoA carboxylase activity|short-chain fatty acid catabolic process|enzyme binding|metal ion binding "hsa00280,hsa00630,hsa00640" "Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism" PCCB 600.7017622 686.1102346 515.2932899 0.751035714 -0.413046581 0.290833491 1 17.83832799 13.97431936 5096 propionyl-CoA carboxylase subunit beta "GO:0004658,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006768,GO:0019626" propionyl-CoA carboxylase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|biotin metabolic process|short-chain fatty acid catabolic process "hsa00280,hsa00630,hsa00640" "Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism" PCDH1 241.389536 370.4589285 112.3201435 0.303191892 -1.721696921 0.000921982 0.08618303 1.986073656 0.628100102 5097 protocadherin 1 "GO:0005509,GO:0005654,GO:0005730,GO:0005886,GO:0005887,GO:0005911,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0030054,GO:0043231" calcium ion binding|nucleoplasm|nucleolus|plasma membrane|integral component of plasma membrane|cell-cell junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|cell junction|intracellular membrane-bounded organelle PCDH12 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.026333985 0.017776524 51294 protocadherin 12 "GO:0005509,GO:0005886,GO:0005887,GO:0005911,GO:0005977,GO:0007155,GO:0007156,GO:0008038,GO:0016339,GO:0060711,GO:0070062" calcium ion binding|plasma membrane|integral component of plasma membrane|cell-cell junction|glycogen metabolic process|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|neuron recognition|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|labyrinthine layer development|extracellular exosome PCDH17 5.552566274 9.134603715 1.970528833 0.215721327 -2.212759283 0.247208451 1 0.03864635 0.008695959 27253 protocadherin 17 "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0030534,GO:0050805,GO:0098978,GO:0098982,GO:0099055,GO:0099056,GO:0099560,GO:1904071,GO:2000807" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|adult behavior|negative regulation of synaptic transmission|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|synaptic membrane adhesion|presynaptic active zone assembly|regulation of synaptic vesicle clustering PCDH18 39.16760104 50.74779842 27.58740366 0.543617743 -0.879335549 0.339008895 1 0.430807402 0.244282699 54510 protocadherin 18 "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0007420" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|brain development PCDH19 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.017680786 0 57526 protocadherin 19 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007420" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|brain development PCDH7 63.3335492 86.27125731 40.39584108 0.468242174 -1.094673213 0.16601257 1 0.310807713 0.151802263 5099 protocadherin 7 "GO:0002576,GO:0005509,GO:0005886,GO:0005887,GO:0007155,GO:0007156,GO:0031092" platelet degranulation|calcium ion binding|plasma membrane|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|platelet alpha granule membrane PCDHA1 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.036749912 0.009302889 56147 protocadherin alpha 1 "GO:0005509,GO:0005576,GO:0005783,GO:0005887,GO:0007155,GO:0007156,GO:0007399" calcium ion binding|extracellular region|endoplasmic reticulum|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development PCDHB10 55.15451834 65.97213794 44.33689874 0.672054903 -0.573348998 0.49183553 1 1.014038255 0.71084518 56126 protocadherin beta 10 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB11 121.2657115 140.0639236 102.4674993 0.731576673 -0.45091902 0.481527595 1 1.708101039 1.303434873 56125 protocadherin beta 11 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB12 76.21621549 91.34603715 61.08639383 0.668736113 -0.580491067 0.437235597 1 1.200714906 0.83754974 56124 protocadherin beta 12 "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0007399" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development PCDHB13 43.16804181 54.80762229 31.52846133 0.575256871 -0.797721783 0.372335038 1 0.548471195 0.329102794 56123 protocadherin beta 13 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB14 90.17322086 102.5105528 77.83588891 0.759296353 -0.397265016 0.577491407 1 1.175412693 0.930931273 56122 protocadherin beta 14 "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB15 79.54587474 83.22638941 75.86536007 0.911554143 -0.133599745 0.870812189 1 1.061476459 1.009273257 56121 protocadherin beta 15 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007399,GO:0032391" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development|photoreceptor connecting cilium PCDHB16 23.04707175 26.38885518 19.70528833 0.74672767 -0.421345905 0.719107993 1 0.348047505 0.271091998 57717 protocadherin beta 16 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB2 134.3562186 159.348087 109.3643502 0.686323584 -0.543039164 0.378512847 1 1.973690013 1.412940247 56133 protocadherin beta 2 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB3 8.552896852 12.17947162 4.926322083 0.404477488 -1.305868687 0.399342453 1 0.183859097 0.077570289 56132 protocadherin beta 3 "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB4 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.067530136 0.068378434 56131 protocadherin beta 4 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB5 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.045223407 0.061055324 26167 protocadherin beta 5 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB6 170.3750313 196.9014579 143.8486048 0.7305614 -0.452922565 0.427194742 1 3.295559886 2.51131887 56130 protocadherin beta 6 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0009988,GO:0016021,GO:0016339,GO:0042802,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|cell-cell recognition|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|identical protein binding|synapse PCDHB7 30.07753465 35.52345889 24.63161041 0.693389979 -0.528261108 0.607597526 1 0.481052907 0.34792556 56129 protocadherin beta 7 "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHB8 101.3525823 125.8545401 76.85062449 0.61063053 -0.711628373 0.292813183 1 2.317850352 1.476317734 56128 protocadherin beta 8 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0042802" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|identical protein binding PCDHB9 96.51805646 98.45072893 94.58538399 0.96073828 -0.057784623 0.948898103 1 1.138137893 1.140554147 56127 protocadherin beta 9 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHGA1 52.60228265 59.88240213 45.32216316 0.756852791 -0.401915375 0.641713755 1 0.481172841 0.379864276 56114 "protocadherin gamma subfamily A, 1" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA10 538.2656406 762.2319322 314.2993489 0.412340832 -1.278090765 0.001655084 0.12602812 5.812158744 2.499825764 56106 "protocadherin gamma subfamily A, 10" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA11 22.13603622 31.46363502 12.80843742 0.40708702 -1.296590873 0.23444893 1 0.274461267 0.116542478 56105 "protocadherin gamma subfamily A, 11" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA12 4.044978098 7.104691779 0.985264417 0.138677996 -2.850189203 0.227217187 1 0.073539255 0.010637577 26025 "protocadherin gamma subfamily A, 12" "GO:0005509,GO:0005887,GO:0005911,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell-cell junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA2 3.970749218 2.029911937 5.911586499 2.912237912 1.542128219 0.515744462 1 0.015287417 0.046438362 56113 "protocadherin gamma subfamily A, 2" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA4 15.59820553 22.3290313 8.867379749 0.397123352 -1.332340898 0.27535031 1 0.231265166 0.095796927 56111 "protocadherin gamma subfamily A, 4" "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0007283" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|spermatogenesis PCDHGA5 6.045198483 9.134603715 2.95579325 0.32358199 -1.627796782 0.370626867 1 0.079778488 0.026926882 56110 "protocadherin gamma subfamily A, 5" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA6 14.09061735 20.29911937 7.882115332 0.388298388 -1.364762376 0.280683921 1 0.129611546 0.052495879 56109 "protocadherin gamma subfamily A, 6" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA8 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.024369756 0 9708 "protocadherin gamma subfamily A, 8" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA9 18.09105812 24.35894324 11.823173 0.485372985 -1.042834281 0.372195395 1 0.251825789 0.127494583 56107 "protocadherin gamma subfamily A, 9" "GO:0003723,GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007283" RNA binding|calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|spermatogenesis PCDHGB1 17.52419703 19.2841634 15.76423066 0.817470291 -0.290761795 0.8448714 1 0.204667822 0.174516894 56104 "protocadherin gamma subfamily B, 1" "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0030426" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|growth cone PCDHGB2 21.59886668 28.41876711 14.77896625 0.520042484 -0.943298608 0.393779446 1 0.302694069 0.164194523 56103 "protocadherin gamma subfamily B, 2" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGB3 6.000661155 6.08973581 5.911586499 0.970745971 -0.042834281 1 1 0.064591337 0.065402719 56102 "protocadherin gamma subfamily B, 3" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGB5 176.4944587 211.1108414 141.878076 0.672054903 -0.573348998 0.308000717 1 2.220564769 1.556625457 56101 "protocadherin gamma subfamily B, 5" "GO:0003674,GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0008150,GO:0070062" molecular_function|calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|biological_process|extracellular exosome PCDHGB6 10.0159477 11.16451565 8.867379749 0.794246703 -0.332340898 0.878848877 1 0.102714502 0.085094818 56100 "protocadherin gamma subfamily B, 6" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGB7 23.15099219 33.49354696 12.80843742 0.382415079 -1.386788682 0.197613337 1 0.3435953 0.137056032 56099 "protocadherin gamma subfamily B, 7" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGC3 2319.25356 3296.576985 1341.930135 0.407067738 -1.29665921 6.44E-05 0.011196983 33.34531549 14.15850648 5098 "protocadherin gamma subfamily C, 3" "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0016020,GO:0016339,GO:0050808" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse organization PCDHGC4 10.55311724 14.20938356 6.896850916 0.485372985 -1.042834281 0.467996854 1 0.145767703 0.073799402 56098 "protocadherin gamma subfamily C, 4" "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0050808" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|synapse organization PCDHGC5 12.59787495 19.2841634 5.911586499 0.306551359 -1.705799294 0.196456571 1 0.19635602 0.062786084 56097 "protocadherin gamma subfamily C, 5" "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0050808" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|synapse organization PCED1A 895.3915784 793.6955673 997.0875895 1.256259491 0.329134496 0.360162893 1 17.04022064 22.32906302 64773 PC-esterase domain containing 1A GO:0005515 protein binding PCED1B 115.9115835 77.1366536 154.6865134 2.005356808 1.003858954 0.121259473 1 0.770552147 1.61179432 91523 PC-esterase domain containing 1B GO:0005515 protein binding PCF11 1124.00509 1132.690861 1115.31932 0.984663475 -0.02229735 0.951284788 1 7.614387603 7.820575964 51585 PCF11 cleavage and polyadenylation factor subunit "GO:0000398,GO:0000993,GO:0003729,GO:0005654,GO:0005737,GO:0005739,GO:0005849,GO:0006369,GO:0006378,GO:0006379,GO:0031124" "mRNA splicing, via spliceosome|RNA polymerase II complex binding|mRNA binding|nucleoplasm|cytoplasm|mitochondrion|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|mRNA 3'-end processing" hsa03015 mRNA surveillance pathway PCGF1 227.1289341 237.4996966 216.7581716 0.912667152 -0.131839287 0.805623457 1 11.34766206 10.80276039 84759 polycomb group ring finger 1 "GO:0000122,GO:0005515,GO:0005634,GO:0005654,GO:0006342,GO:0006355,GO:0008022,GO:0031519,GO:0035102,GO:0035518,GO:0036353,GO:0046872,GO:1990841" "negative regulation of transcription by RNA polymerase II|protein binding|nucleus|nucleoplasm|chromatin silencing|regulation of transcription, DNA-templated|protein C-terminus binding|PcG protein complex|PRC1 complex|histone H2A monoubiquitination|histone H2A-K119 monoubiquitination|metal ion binding|promoter-specific chromatin binding" hsa04550 Signaling pathways regulating pluripotency of stem cells other PCGF2 1914.933154 1688.886731 2140.979577 1.267686895 0.34219846 0.289992352 1 20.60119338 27.24082833 7703 polycomb group ring finger 2 "GO:0000122,GO:0000785,GO:0001701,GO:0001739,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006342,GO:0009952,GO:0016573,GO:0016604,GO:0031519,GO:0035102,GO:0036353,GO:0046872,GO:0048704,GO:0070301,GO:0070317,GO:1990841,GO:2001234" negative regulation of transcription by RNA polymerase II|chromatin|in utero embryonic development|sex chromatin|DNA binding|protein binding|nucleus|nucleoplasm|chromatin silencing|anterior/posterior pattern specification|histone acetylation|nuclear body|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|metal ion binding|embryonic skeletal system morphogenesis|cellular response to hydrogen peroxide|negative regulation of G0 to G1 transition|promoter-specific chromatin binding|negative regulation of apoptotic signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells chromosome_remodelling_factor PCGF3 892.8811584 824.1442463 961.6180705 1.166807965 0.222567139 0.536966789 1 6.891200045 8.387068149 10336 polycomb group ring finger 3 "GO:0000805,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0031519,GO:0035102,GO:0036353,GO:0046872,GO:0060819" X chromosome|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|metal ion binding|inactivation of X chromosome by genetic imprinting hsa04550 Signaling pathways regulating pluripotency of stem cells PCGF5 2333.111343 2324.249168 2341.973518 1.007625839 0.010960024 0.974120435 1 14.98981547 15.75474986 84333 polycomb group ring finger 5 "GO:0000805,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005813,GO:0006357,GO:0031519,GO:0035102,GO:0036353,GO:0045944,GO:0046872,GO:0060819" X chromosome|protein binding|nucleus|nucleoplasm|Golgi apparatus|centrosome|regulation of transcription by RNA polymerase II|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|positive regulation of transcription by RNA polymerase II|metal ion binding|inactivation of X chromosome by genetic imprinting hsa04550 Signaling pathways regulating pluripotency of stem cells PCGF6 826.111308 772.3814919 879.841124 1.139127663 0.18792944 0.608086858 1 17.49481117 20.78727625 84108 polycomb group ring finger 6 "GO:0000122,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0031519,GO:0035102,GO:0036353,GO:0045892,GO:0046872,GO:0070317" "negative regulation of transcription by RNA polymerase II|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|negative regulation of transcription, DNA-templated|metal ion binding|negative regulation of G0 to G1 transition" hsa04550 Signaling pathways regulating pluripotency of stem cells other PCID2 921.9140456 855.6078813 988.2202098 1.154991944 0.207882788 0.56197478 1 4.219838425 5.083826341 55795 PCI domain containing 2 "GO:0000973,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0006368,GO:0016973,GO:0043066,GO:0043488,GO:0044615,GO:0045579,GO:0045893,GO:0048536,GO:0070390,GO:0071033,GO:0090267,GO:2000117" "posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|double-stranded DNA binding|RNA binding|protein binding|nucleus|cytoplasm|transcription elongation from RNA polymerase II promoter|poly(A)+ mRNA export from nucleus|negative regulation of apoptotic process|regulation of mRNA stability|nuclear pore nuclear basket|positive regulation of B cell differentiation|positive regulation of transcription, DNA-templated|spleen development|transcription export complex 2|nuclear retention of pre-mRNA at the site of transcription|positive regulation of mitotic cell cycle spindle assembly checkpoint|negative regulation of cysteine-type endopeptidase activity" PCIF1 901.3949612 766.2917561 1036.498166 1.352615577 0.435751874 0.225007915 1 13.56517796 19.13884873 63935 phosphorylated CTD interacting factor 1 "GO:0005634,GO:0005654,GO:0006417,GO:0010923,GO:0015630,GO:0016422,GO:0017148,GO:0045171,GO:0045727,GO:0080009,GO:0099122,GO:1904047,GO:1990269" nucleus|nucleoplasm|regulation of translation|negative regulation of phosphatase activity|microtubule cytoskeleton|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|negative regulation of translation|intercellular bridge|positive regulation of translation|mRNA methylation|RNA polymerase II C-terminal domain binding|S-adenosyl-L-methionine binding|RNA polymerase II C-terminal domain phosphoserine binding PCK2 1108.811926 902.2958559 1315.327996 1.457756885 0.543750136 0.116777606 1 16.32658163 24.8254023 5106 "phosphoenolpyruvate carboxykinase 2, mitochondrial" "GO:0004611,GO:0004613,GO:0005515,GO:0005525,GO:0005739,GO:0005759,GO:0005829,GO:0006094,GO:0006107,GO:0006116,GO:0019543,GO:0030145,GO:0032024,GO:0032496,GO:0032869,GO:0033993,GO:0042594,GO:0046327,GO:0070365,GO:0071333,GO:0071356,GO:0071549" phosphoenolpyruvate carboxykinase activity|phosphoenolpyruvate carboxykinase (GTP) activity|protein binding|GTP binding|mitochondrion|mitochondrial matrix|cytosol|gluconeogenesis|oxaloacetate metabolic process|NADH oxidation|propionate catabolic process|manganese ion binding|positive regulation of insulin secretion|response to lipopolysaccharide|cellular response to insulin stimulus|response to lipid|response to starvation|glycerol biosynthetic process from pyruvate|hepatocyte differentiation|cellular response to glucose stimulus|cellular response to tumor necrosis factor|cellular response to dexamethasone stimulus "hsa00010,hsa00020,hsa00620,hsa03320,hsa04068,hsa04151,hsa04152,hsa04910,hsa04920,hsa04922,hsa04931,hsa04964" Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|PPAR signaling pathway|FoxO signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Proximal tubule bicarbonate reclamation PCLAF 992.0108337 932.7445349 1051.277132 1.12707938 0.172589128 0.626044572 1 22.15770177 26.04924539 9768 PCNA clamp associated factor "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0006260,GO:0006974,GO:0007098,GO:0009411,GO:0019985,GO:0048471,GO:0051726" chromatin binding|protein binding|nucleus|nucleoplasm|centrosome|DNA replication|cellular response to DNA damage stimulus|centrosome cycle|response to UV|translesion synthesis|perinuclear region of cytoplasm|regulation of cell cycle PCLO 667.0032289 806.8899949 527.1164629 0.653269301 -0.61425025 0.107900598 1 1.734702933 1.182043046 27445 piccolo presynaptic cytomatrix protein "GO:0005509,GO:0005522,GO:0005544,GO:0005856,GO:0007010,GO:0014069,GO:0016079,GO:0017157,GO:0019933,GO:0030073,GO:0030424,GO:0035418,GO:0045202,GO:0048788,GO:0048790,GO:0070062,GO:0097091,GO:0098882,GO:0098978,GO:0098982,GO:0099526,GO:1904071" calcium ion binding|profilin binding|calcium-dependent phospholipid binding|cytoskeleton|cytoskeleton organization|postsynaptic density|synaptic vesicle exocytosis|regulation of exocytosis|cAMP-mediated signaling|insulin secretion|axon|protein localization to synapse|synapse|cytoskeleton of presynaptic active zone|maintenance of presynaptic active zone structure|extracellular exosome|synaptic vesicle clustering|structural constituent of presynaptic active zone|glutamatergic synapse|GABA-ergic synapse|presynapse to nucleus signaling pathway|presynaptic active zone assembly hsa04911 Insulin secretion PCM1 1702.325365 1501.119877 1903.530853 1.268073844 0.34263876 0.294555264 1 7.275952354 9.623882695 5108 pericentriolar material 1 "GO:0000086,GO:0000242,GO:0001764,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0007098,GO:0010389,GO:0016020,GO:0022027,GO:0031122,GO:0031965,GO:0032991,GO:0034451,GO:0034453,GO:0034454,GO:0035176,GO:0035735,GO:0035869,GO:0036064,GO:0042802,GO:0045177,GO:0050768,GO:0060271,GO:0071539,GO:0090316,GO:0097150,GO:0097711,GO:0097730,GO:1905515" G2/M transition of mitotic cell cycle|pericentriolar material|neuron migration|protein binding|cytoplasm|centrosome|centriole|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|membrane|interkinetic nuclear migration|cytoplasmic microtubule organization|nuclear membrane|protein-containing complex|centriolar satellite|microtubule anchoring|microtubule anchoring at centrosome|social behavior|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|identical protein binding|apical part of cell|negative regulation of neurogenesis|cilium assembly|protein localization to centrosome|positive regulation of intracellular protein transport|neuronal stem cell population maintenance|ciliary basal body-plasma membrane docking|non-motile cilium|non-motile cilium assembly PCMT1 1473.660389 1428.043048 1519.27773 1.063887908 0.089346155 0.789502577 1 33.67101607 37.36526138 5110 protein-L-isoaspartate (D-aspartate) O-methyltransferase "GO:0004719,GO:0005515,GO:0005737,GO:0005829,GO:0006479,GO:0030091,GO:0045296,GO:0070062,GO:1903561" protein-L-isoaspartate (D-aspartate) O-methyltransferase activity|protein binding|cytoplasm|cytosol|protein methylation|protein repair|cadherin binding|extracellular exosome|extracellular vesicle PCMTD1 1156.98324 928.6847111 1385.28177 1.491659928 0.576918665 0.093940605 1 10.05657567 15.6471728 115294 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 "GO:0004719,GO:0005515,GO:0005737,GO:0006479,GO:0016020" protein-L-isoaspartate (D-aspartate) O-methyltransferase activity|protein binding|cytoplasm|protein methylation|membrane PCMTD2 1121.401636 1022.06066 1220.742612 1.194393503 0.256278223 0.459001517 1 13.41377736 16.71146238 55251 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 "GO:0004719,GO:0005515,GO:0005737,GO:0006479" protein-L-isoaspartate (D-aspartate) O-methyltransferase activity|protein binding|cytoplasm|protein methylation PCNA 6204.223907 5524.405336 6884.042478 1.24611466 0.317436823 0.328926503 1 199.9940253 259.9506793 5111 proliferating cell nuclear antigen "GO:0000083,GO:0000122,GO:0000307,GO:0000701,GO:0000723,GO:0000781,GO:0000785,GO:0003682,GO:0003684,GO:0005515,GO:0005634,GO:0005652,GO:0005654,GO:0005657,GO:0005813,GO:0006272,GO:0006283,GO:0006287,GO:0006296,GO:0006297,GO:0006298,GO:0006977,GO:0007507,GO:0008022,GO:0016032,GO:0016567,GO:0016604,GO:0019899,GO:0019985,GO:0030331,GO:0030337,GO:0030855,GO:0030894,GO:0030971,GO:0031297,GO:0032077,GO:0032139,GO:0032201,GO:0032355,GO:0032405,GO:0033683,GO:0034644,GO:0035035,GO:0042276,GO:0042769,GO:0042802,GO:0043596,GO:0043626,GO:0044849,GO:0044877,GO:0045739,GO:0045740,GO:0046686,GO:0070062,GO:0070182,GO:0070301,GO:0070557,GO:0070987,GO:0071466,GO:0071548,GO:0097421,GO:1900264,GO:1902065,GO:1902990" "regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|cyclin-dependent protein kinase holoenzyme complex|purine-specific mismatch base pair DNA N-glycosylase activity|telomere maintenance|chromosome, telomeric region|chromatin|chromatin binding|damaged DNA binding|protein binding|nucleus|nuclear lamina|nucleoplasm|replication fork|centrosome|leading strand elongation|transcription-coupled nucleotide-excision repair|base-excision repair, gap-filling|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|heart development|protein C-terminus binding|viral process|protein ubiquitination|nuclear body|enzyme binding|translesion synthesis|estrogen receptor binding|DNA polymerase processivity factor activity|epithelial cell differentiation|replisome|receptor tyrosine kinase binding|replication fork processing|positive regulation of deoxyribonuclease activity|dinucleotide insertion or deletion binding|telomere maintenance via semi-conservative replication|response to estradiol|MutLalpha complex binding|nucleotide-excision repair, DNA incision|cellular response to UV|histone acetyltransferase binding|error-prone translesion synthesis|DNA damage response, detection of DNA damage|identical protein binding|nuclear replication fork|PCNA complex|estrous cycle|protein-containing complex binding|positive regulation of DNA repair|positive regulation of DNA replication|response to cadmium ion|extracellular exosome|DNA polymerase binding|cellular response to hydrogen peroxide|PCNA-p21 complex|error-free translesion synthesis|cellular response to xenobiotic stimulus|response to dexamethasone|liver regeneration|positive regulation of DNA-directed DNA polymerase activity|response to L-glutamate|mitotic telomere maintenance via semi-conservative replication" "hsa03030,hsa03410,hsa03420,hsa03430,hsa04110,hsa04530,hsa05161" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Cell cycle|Tight junction|Hepatitis B PCNP 2455.532549 2206.514275 2704.550823 1.225711908 0.293619928 0.357764114 1 44.32850612 56.67446524 57092 PEST proteolytic signal containing nuclear protein "GO:0005515,GO:0005634,GO:0005654,GO:0007049,GO:0016567,GO:0016604,GO:0043161" protein binding|nucleus|nucleoplasm|cell cycle|protein ubiquitination|nuclear body|proteasome-mediated ubiquitin-dependent protein catabolic process PCNT 2410.138879 2167.945948 2652.331809 1.223430783 0.290932482 0.362410495 1 9.599476677 12.25019188 5116 pericentrin "GO:0000086,GO:0000226,GO:0005515,GO:0005516,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0007052,GO:0007165,GO:0010389,GO:0016020,GO:0034451,GO:0060090,GO:0060271,GO:0090316,GO:0097711" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|protein binding|calmodulin binding|centrosome|centriole|cytosol|microtubule|mitotic spindle organization|signal transduction|regulation of G2/M transition of mitotic cell cycle|membrane|centriolar satellite|molecular adaptor activity|cilium assembly|positive regulation of intracellular protein transport|ciliary basal body-plasma membrane docking PCNX1 3666.485368 3086.4811 4246.489635 1.375835295 0.460307772 0.148543072 1 11.85225409 17.00917815 22990 pecanex 1 GO:0016021 integral component of membrane PCNX2 758.2050137 743.9627248 772.4473026 1.038287641 0.054206175 0.887316774 1 4.29685112 4.653545028 80003 pecanex 2 "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane PCNX3 2615.421765 2663.244461 2567.59907 0.96408689 -0.052764917 0.869557583 1 15.02382898 15.10820045 399909 pecanex 3 GO:0016021 integral component of membrane PCNX4 2218.495547 2099.943899 2337.047196 1.112909349 0.154336083 0.630473032 1 5.882127665 6.828261839 64430 pecanex 4 "GO:0005515,GO:0016021" protein binding|integral component of membrane PCOLCE 130.9995894 131.9442759 130.054903 0.985680524 -0.020807975 0.987119646 1 3.274136258 3.366269284 5118 procollagen C-endopeptidase enhancer "GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0007275,GO:0008201,GO:0010952,GO:0016504,GO:0062023,GO:0070062" extracellular matrix structural constituent|protein binding|collagen binding|extracellular region|extracellular space|multicellular organism development|heparin binding|positive regulation of peptidase activity|peptidase activator activity|collagen-containing extracellular matrix|extracellular exosome PCOLCE2 24.56950571 29.43372308 19.70528833 0.66947998 -0.578887181 0.597404471 1 0.786241687 0.549047086 26577 procollagen C-endopeptidase enhancer 2 "GO:0005518,GO:0005576,GO:0008201,GO:0010952,GO:0016504,GO:1990830" collagen binding|extracellular region|heparin binding|positive regulation of peptidase activity|peptidase activator activity|cellular response to leukemia inhibitory factor PCOTH 7.508249331 8.119647747 6.896850916 0.849402724 -0.235479359 0.974243744 1 0.37693081 0.333957512 542767 Pro-X-Gly collagen triple helix like repeat containing "GO:0005515,GO:0005737" protein binding|cytoplasm PCP2 5.059934066 9.134603715 0.985264417 0.107860663 -3.212759283 0.136251646 1 0.298860112 0.033623814 126006 Purkinje cell protein 2 "GO:0005085,GO:0005515,GO:0043025,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|neuronal cell body|regulation of catalytic activity PCSK1N 474.6015249 518.6424998 430.56055 0.830168276 -0.268524293 0.518169453 1 25.62674435 22.1909298 27344 proprotein convertase subtilisin/kexin type 1 inhibitor "GO:0002021,GO:0004866,GO:0004867,GO:0005102,GO:0005615,GO:0005802,GO:0007218,GO:0009409,GO:0010951,GO:0016486,GO:0030141" response to dietary excess|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|signaling receptor binding|extracellular space|trans-Golgi network|neuropeptide signaling pathway|response to cold|negative regulation of endopeptidase activity|peptide hormone processing|secretory granule PCSK4 60.87310976 52.77771036 68.96850916 1.306773422 0.386009018 0.63871118 1 0.838195309 1.142513785 54760 proprotein convertase subtilisin/kexin type 4 "GO:0001669,GO:0002080,GO:0004252,GO:0005515,GO:0005802,GO:0007339,GO:0007340,GO:0009566,GO:0016020,GO:0016485,GO:0016486,GO:0022414,GO:0030173,GO:0048240" acrosomal vesicle|acrosomal membrane|serine-type endopeptidase activity|protein binding|trans-Golgi network|binding of sperm to zona pellucida|acrosome reaction|fertilization|membrane|protein processing|peptide hormone processing|reproductive process|integral component of Golgi membrane|sperm capacitation PCSK5 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.010679489 0.010813642 5125 proprotein convertase subtilisin/kexin type 5 "GO:0001822,GO:0002001,GO:0004175,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0005796,GO:0005802,GO:0006465,GO:0007267,GO:0007507,GO:0007566,GO:0008233,GO:0009952,GO:0016020,GO:0016485,GO:0016486,GO:0019058,GO:0030141,GO:0030173,GO:0030323,GO:0032455,GO:0035108,GO:0042277,GO:0043043,GO:0048566,GO:0048706,GO:0051004,GO:0140447" kidney development|renin secretion into blood stream|endopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|Golgi apparatus|Golgi lumen|trans-Golgi network|signal peptide processing|cell-cell signaling|heart development|embryo implantation|peptidase activity|anterior/posterior pattern specification|membrane|protein processing|peptide hormone processing|viral life cycle|secretory granule|integral component of Golgi membrane|respiratory tube development|nerve growth factor processing|limb morphogenesis|peptide binding|peptide biosynthetic process|embryonic digestive tract development|embryonic skeletal system development|regulation of lipoprotein lipase activity|cytokine precursor processing PCSK6 447.2570969 467.8947014 426.6194924 0.911785261 -0.133234007 0.755133935 1 3.899492512 3.708656308 5046 proprotein convertase subtilisin/kexin type 6 "GO:0004175,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005796,GO:0005886,GO:0008201,GO:0009100,GO:0009986,GO:0016020,GO:0016485,GO:0016486,GO:0030510,GO:0032455,GO:0032902,GO:0032940,GO:0048406,GO:0051004,GO:0062023,GO:0070268" endopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum|Golgi lumen|plasma membrane|heparin binding|glycoprotein metabolic process|cell surface|membrane|protein processing|peptide hormone processing|regulation of BMP signaling pathway|nerve growth factor processing|nerve growth factor production|secretion by cell|nerve growth factor binding|regulation of lipoprotein lipase activity|collagen-containing extracellular matrix|cornification PCSK7 1329.273377 1256.515489 1402.031265 1.115808979 0.158090066 0.639907269 1 10.92874408 12.71967567 9159 proprotein convertase subtilisin/kexin type 7 "GO:0004252,GO:0005515,GO:0005802,GO:0008233,GO:0016020,GO:0016485,GO:0016486,GO:0030173" serine-type endopeptidase activity|protein binding|trans-Golgi network|peptidase activity|membrane|protein processing|peptide hormone processing|integral component of Golgi membrane PCSK9 4.493072978 4.059823873 4.926322083 1.213432463 0.279093814 1 1 0.05653444 0.071555765 255738 proprotein convertase subtilisin/kexin type 9 "GO:0001822,GO:0001889,GO:0001920,GO:0002092,GO:0003723,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005783,GO:0005788,GO:0005791,GO:0005794,GO:0005886,GO:0006641,GO:0006644,GO:0006915,GO:0007041,GO:0008203,GO:0009267,GO:0009986,GO:0010469,GO:0010989,GO:0016540,GO:0019871,GO:0022008,GO:0030134,GO:0030169,GO:0030182,GO:0030547,GO:0031232,GO:0032802,GO:0032805,GO:0032869,GO:0034185,GO:0034189,GO:0034190,GO:0034383,GO:0036020,GO:0042157,GO:0042632,GO:0043523,GO:0043525,GO:0043621,GO:0043687,GO:0044267,GO:0048471,GO:0050750,GO:0070326,GO:1905596,GO:1905598,GO:1905601,GO:1990666,GO:1990667,GO:2000272,GO:2000650" kidney development|liver development|negative regulation of receptor recycling|positive regulation of receptor internalization|RNA binding|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|cytoplasm|lysosome|lysosomal membrane|early endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum lumen|rough endoplasmic reticulum|Golgi apparatus|plasma membrane|triglyceride metabolic process|phospholipid metabolic process|apoptotic process|lysosomal transport|cholesterol metabolic process|cellular response to starvation|cell surface|regulation of signaling receptor activity|negative regulation of low-density lipoprotein particle clearance|protein autoprocessing|sodium channel inhibitor activity|neurogenesis|COPII-coated ER to Golgi transport vesicle|low-density lipoprotein particle binding|neuron differentiation|receptor inhibitor activity|extrinsic component of external side of plasma membrane|low-density lipoprotein particle receptor catabolic process|positive regulation of low-density lipoprotein particle receptor catabolic process|cellular response to insulin stimulus|apolipoprotein binding|very-low-density lipoprotein particle binding|apolipoprotein receptor binding|low-density lipoprotein particle clearance|endolysosome membrane|lipoprotein metabolic process|cholesterol homeostasis|regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|protein self-association|post-translational protein modification|cellular protein metabolic process|perinuclear region of cytoplasm|low-density lipoprotein particle receptor binding|very-low-density lipoprotein particle receptor binding|negative regulation of low-density lipoprotein particle receptor binding|negative regulation of low-density lipoprotein receptor activity|negative regulation of receptor-mediated endocytosis involved in cholesterol transport|PCSK9-LDLR complex|PCSK9-AnxA2 complex|negative regulation of signaling receptor activity|negative regulation of sodium ion transmembrane transporter activity hsa04979 Cholesterol metabolism PCTP 280.0605454 286.2175831 273.9035078 0.956976524 -0.063444561 0.90281022 1 4.38472803 4.376831975 58488 phosphatidylcholine transfer protein "GO:0005515,GO:0005829,GO:0006656,GO:0006869,GO:0008525,GO:0015914,GO:0031210,GO:0120163" protein binding|cytosol|phosphatidylcholine biosynthetic process|lipid transport|phosphatidylcholine transporter activity|phospholipid transport|phosphatidylcholine binding|negative regulation of cold-induced thermogenesis PCYOX1 2023.923392 2067.465308 1980.381477 0.95787894 -0.06208476 0.848382937 1 19.61225403 19.5953969 51449 prenylcysteine oxidase 1 "GO:0001735,GO:0005515,GO:0005764,GO:0005886,GO:0008555,GO:0030327,GO:0030328,GO:0034361,GO:0055114,GO:0070062,GO:1902476" prenylcysteine oxidase activity|protein binding|lysosome|plasma membrane|ATPase-coupled chloride transmembrane transporter activity|prenylated protein catabolic process|prenylcysteine catabolic process|very-low-density lipoprotein particle|oxidation-reduction process|extracellular exosome|chloride transmembrane transport hsa00900 Terpenoid backbone biosynthesis PCYOX1L 223.4699462 256.78386 190.1560324 0.740529535 -0.433370819 0.405937294 1 5.040773888 3.893637634 78991 prenylcysteine oxidase 1 like "GO:0001735,GO:0002576,GO:0005576,GO:0016020,GO:0030327,GO:0030328,GO:0031093,GO:0055114" prenylcysteine oxidase activity|platelet degranulation|extracellular region|membrane|prenylated protein catabolic process|prenylcysteine catabolic process|platelet alpha granule lumen|oxidation-reduction process PCYT1A 1657.074463 1910.147132 1404.001794 0.735022852 -0.44413899 0.175561136 1 17.24460137 13.22117126 5130 "phosphate cytidylyltransferase 1, choline, alpha" "GO:0004105,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005829,GO:0006656,GO:0006657,GO:0031210,GO:0042587,GO:0042802" choline-phosphate cytidylyltransferase activity|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|phosphatidylcholine biosynthetic process|CDP-choline pathway|phosphatidylcholine binding|glycogen granule|identical protein binding "hsa00440,hsa00564,hsa05231" Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Choline metabolism in cancer PCYT2 432.5550811 439.4759343 425.6342279 0.968504063 -0.046169994 0.918853498 1 3.94643718 3.986782752 5833 "phosphate cytidylyltransferase 2, ethanolamine" "GO:0004306,GO:0005515,GO:0005575,GO:0005789,GO:0006646,GO:0008654" ethanolamine-phosphate cytidylyltransferase activity|protein binding|cellular_component|endoplasmic reticulum membrane|phosphatidylethanolamine biosynthetic process|phospholipid biosynthetic process "hsa00440,hsa00564" Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism PDAP1 3151.160902 3286.427426 3015.894379 0.917681722 -0.123934222 0.697271789 1 63.91933767 61.18433971 11333 PDGFA associated protein 1 "GO:0003723,GO:0005515,GO:0005576,GO:0005829,GO:0005886,GO:0007165,GO:0043312,GO:1904813" RNA binding|protein binding|extracellular region|cytosol|plasma membrane|signal transduction|neutrophil degranulation|ficolin-1-rich granule lumen PDCD10 748.7856186 739.9029009 757.6683363 1.024010496 0.034230502 0.930435406 1 11.0769943 11.83156707 11235 programmed cell death 10 "GO:0000139,GO:0001525,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0008284,GO:0010628,GO:0010629,GO:0019901,GO:0030335,GO:0032874,GO:0033138,GO:0035023,GO:0036481,GO:0042542,GO:0042803,GO:0043066,GO:0043149,GO:0043406,GO:0044319,GO:0045747,GO:0047485,GO:0050821,GO:0051683,GO:0070062,GO:0071902,GO:0090051,GO:0090168,GO:0090316,GO:0090443,GO:1903358,GO:1903588,GO:1990830" "Golgi membrane|angiogenesis|protein binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|positive regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|protein kinase binding|positive regulation of cell migration|positive regulation of stress-activated MAPK cascade|positive regulation of peptidyl-serine phosphorylation|regulation of Rho protein signal transduction|intrinsic apoptotic signaling pathway in response to hydrogen peroxide|response to hydrogen peroxide|protein homodimerization activity|negative regulation of apoptotic process|stress fiber assembly|positive regulation of MAP kinase activity|wound healing, spreading of cells|positive regulation of Notch signaling pathway|protein N-terminus binding|protein stabilization|establishment of Golgi localization|extracellular exosome|positive regulation of protein serine/threonine kinase activity|negative regulation of cell migration involved in sprouting angiogenesis|Golgi reassembly|positive regulation of intracellular protein transport|FAR/SIN/STRIPAK complex|regulation of Golgi organization|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|cellular response to leukemia inhibitory factor" PDCD11 3945.859794 4100.422112 3791.297475 0.924611509 -0.113080775 0.723069993 1 31.7784108 30.64837122 22984 programmed cell death 11 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0006397,GO:0008134,GO:0032040" RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|rRNA processing|mRNA processing|transcription factor binding|small-subunit processome PDCD1LG2 71.84463032 61.91231407 81.77694657 1.320851075 0.401467813 0.603562152 1 1.24183774 1.710939441 80380 programmed cell death 1 ligand 2 "GO:0002250,GO:0003674,GO:0005515,GO:0005576,GO:0005886,GO:0006955,GO:0007166,GO:0009897,GO:0012505,GO:0016021,GO:0031295,GO:0032689,GO:0032693,GO:0042102,GO:0042130,GO:0046007,GO:0071222" adaptive immune response|molecular_function|protein binding|extracellular region|plasma membrane|immune response|cell surface receptor signaling pathway|external side of plasma membrane|endomembrane system|integral component of membrane|T cell costimulation|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|positive regulation of T cell proliferation|negative regulation of T cell proliferation|negative regulation of activated T cell proliferation|cellular response to lipopolysaccharide hsa04514 Cell adhesion molecules PDCD2 713.6899656 731.7832532 695.5966781 0.950550146 -0.073165357 0.849019665 1 6.741040414 6.683714547 5134 programmed cell death 2 "GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0006915,GO:0006919,GO:0019899,GO:0043065,GO:0046872,GO:0070062,GO:1901532,GO:1902035" DNA binding|protein binding|nucleus|cytoplasm|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|enzyme binding|positive regulation of apoptotic process|metal ion binding|extracellular exosome|regulation of hematopoietic progenitor cell differentiation|positive regulation of hematopoietic stem cell proliferation PDCD2L 129.640459 140.0639236 119.2169944 0.851161322 -0.232495501 0.716405965 1 6.13115265 5.443396118 84306 programmed cell death 2 like "GO:0005515,GO:0005737,GO:0007049,GO:0016020" protein binding|cytoplasm|cell cycle|membrane PDCD4 620.7378631 472.9694813 768.5062449 1.62485377 0.700309888 0.071560574 1 6.719280698 11.38814522 27250 programmed cell death 4 "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0007569,GO:0030509,GO:0035722,GO:0043066,GO:0043508,GO:0045786,GO:0045892,GO:0050729,GO:0060940,GO:0071222,GO:1900016,GO:1901224,GO:1904706,GO:1904761,GO:1905064,GO:1905461,GO:2000353" "RNA binding|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|cell aging|BMP signaling pathway|interleukin-12-mediated signaling pathway|negative regulation of apoptotic process|negative regulation of JUN kinase activity|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of inflammatory response|epithelial to mesenchymal transition involved in cardiac fibroblast development|cellular response to lipopolysaccharide|negative regulation of cytokine production involved in inflammatory response|positive regulation of NIK/NF-kappaB signaling|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of myofibroblast differentiation|negative regulation of vascular associated smooth muscle cell differentiation|positive regulation of vascular associated smooth muscle cell apoptotic process|positive regulation of endothelial cell apoptotic process" "hsa05205,hsa05206" Proteoglycans in cancer|MicroRNAs in cancer PDCD5 863.4986536 869.8172649 857.1800424 0.985471405 -0.021114085 0.956912333 1 23.48250316 24.13817027 9141 programmed cell death 5 "GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0008201,GO:0008285,GO:0010628,GO:0010698,GO:0043065,GO:0043280,GO:0048487,GO:0070062,GO:0071560,GO:0090200,GO:1903638,GO:1903645" DNA binding|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|heparin binding|negative regulation of cell population proliferation|positive regulation of gene expression|acetyltransferase activator activity|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|beta-tubulin binding|extracellular exosome|cellular response to transforming growth factor beta stimulus|positive regulation of release of cytochrome c from mitochondria|positive regulation of protein insertion into mitochondrial outer membrane|negative regulation of chaperone-mediated protein folding PDCD6 2141.902744 2050.211056 2233.594432 1.089446097 0.123594817 0.70087187 1 101.303373 115.1186221 10016 programmed cell death 6 "GO:0000139,GO:0000287,GO:0001525,GO:0001938,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005783,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006919,GO:0010595,GO:0014029,GO:0014032,GO:0016567,GO:0030127,GO:0030674,GO:0030948,GO:0031410,GO:0031463,GO:0032007,GO:0034605,GO:0036324,GO:0042802,GO:0042803,GO:0043280,GO:0043495,GO:0045766,GO:0046983,GO:0048208,GO:0048306,GO:0051592,GO:0051898,GO:0070062,GO:0070971,GO:0097190,GO:1902527,GO:1990756" Golgi membrane|magnesium ion binding|angiogenesis|positive regulation of endothelial cell proliferation|calcium ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of endothelial cell migration|neural crest formation|neural crest cell development|protein ubiquitination|COPII vesicle coat|protein-macromolecule adaptor activity|negative regulation of vascular endothelial growth factor receptor signaling pathway|cytoplasmic vesicle|Cul3-RING ubiquitin ligase complex|negative regulation of TOR signaling|cellular response to heat|vascular endothelial growth factor receptor-2 signaling pathway|identical protein binding|protein homodimerization activity|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein-membrane adaptor activity|positive regulation of angiogenesis|protein dimerization activity|COPII vesicle coating|calcium-dependent protein binding|response to calcium ion|negative regulation of protein kinase B signaling|extracellular exosome|endoplasmic reticulum exit site|apoptotic signaling pathway|positive regulation of protein monoubiquitination|ubiquitin ligase-substrate adaptor activity PDCD6IP 4640.20918 4385.624739 4894.793621 1.11609951 0.158465661 0.62076452 1 33.57769032 39.09035968 10015 programmed cell death 6 interacting protein "GO:0000281,GO:0000915,GO:0001772,GO:0005515,GO:0005815,GO:0005829,GO:0005923,GO:0005925,GO:0006915,GO:0006997,GO:0007080,GO:0010824,GO:0015031,GO:0016020,GO:0019058,GO:0031871,GO:0036258,GO:0039702,GO:0042470,GO:0042641,GO:0042803,GO:0043231,GO:0045199,GO:0046755,GO:0048306,GO:0051260,GO:0061952,GO:0070062,GO:0070830,GO:0070971,GO:0090543,GO:0090559,GO:0090611,GO:1901673,GO:1903543,GO:1903551,GO:1903553,GO:1903561" mitotic cytokinesis|actomyosin contractile ring assembly|immunological synapse|protein binding|microtubule organizing center|cytosol|bicellular tight junction|focal adhesion|apoptotic process|nucleus organization|mitotic metaphase plate congression|regulation of centrosome duplication|protein transport|membrane|viral life cycle|proteinase activated receptor binding|multivesicular body assembly|viral budding via host ESCRT complex|melanosome|actomyosin|protein homodimerization activity|intracellular membrane-bounded organelle|maintenance of epithelial cell apical/basal polarity|viral budding|calcium-dependent protein binding|protein homooligomerization|midbody abscission|extracellular exosome|bicellular tight junction assembly|endoplasmic reticulum exit site|Flemming body|regulation of membrane permeability|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|regulation of mitotic spindle assembly|positive regulation of exosomal secretion|regulation of extracellular exosome assembly|positive regulation of extracellular exosome assembly|extracellular vesicle hsa04144 Endocytosis PDCD7 513.4803753 448.610538 578.3502125 1.289203359 0.366479852 0.367166456 1 8.048367392 10.82293751 10081 programmed cell death 7 "GO:0000398,GO:0005654,GO:0005689,GO:0006915,GO:0008380,GO:0051384" "mRNA splicing, via spliceosome|nucleoplasm|U12-type spliceosomal complex|apoptotic process|RNA splicing|response to glucocorticoid" PDCL 691.4054717 690.1700585 692.6408848 1.003580025 0.005155662 0.993493672 1 11.5859061 12.12824448 5082 phosducin like "GO:0005515,GO:0005737,GO:0005829,GO:0005929,GO:0006457,GO:0007165,GO:0007601,GO:0008277,GO:0030030,GO:0044877,GO:0045880,GO:0061084,GO:1902605" protein binding|cytoplasm|cytosol|cilium|protein folding|signal transduction|visual perception|regulation of G protein-coupled receptor signaling pathway|cell projection organization|protein-containing complex binding|positive regulation of smoothened signaling pathway|negative regulation of protein refolding|heterotrimeric G-protein complex assembly PDCL3 344.512971 381.6234441 307.402498 0.805512614 -0.312020914 0.49275279 1 9.57774091 8.047321644 79031 phosducin like 3 "GO:0001525,GO:0001938,GO:0005515,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006915,GO:0010628,GO:0030036,GO:0032991,GO:0034605,GO:0043184,GO:0044183,GO:0045766,GO:0048471,GO:0050730,GO:0050821,GO:0061077,GO:0097356,GO:1903645,GO:2000059" angiogenesis|positive regulation of endothelial cell proliferation|protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|apoptotic process|positive regulation of gene expression|actin cytoskeleton organization|protein-containing complex|cellular response to heat|vascular endothelial growth factor receptor 2 binding|protein folding chaperone|positive regulation of angiogenesis|perinuclear region of cytoplasm|regulation of peptidyl-tyrosine phosphorylation|protein stabilization|chaperone-mediated protein folding|perinucleolar compartment|negative regulation of chaperone-mediated protein folding|negative regulation of ubiquitin-dependent protein catabolic process PDE10A 660.7462301 648.5568638 672.9355965 1.037589199 0.053235366 0.893101667 1 2.175738039 2.354767193 10846 phosphodiesterase 10A "GO:0004114,GO:0004118,GO:0005829,GO:0006198,GO:0007165,GO:0007186,GO:0010754,GO:0030552,GO:0030553,GO:0046069,GO:0046872,GO:0047555" "3',5'-cyclic-nucleotide phosphodiesterase activity|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|cytosol|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|negative regulation of cGMP-mediated signaling|cAMP binding|cGMP binding|cGMP catabolic process|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity" "hsa00230,hsa04024,hsa05032" Purine metabolism|cAMP signaling pathway|Morphine addiction PDE11A 6.015506931 7.104691779 4.926322083 0.693389979 -0.528261108 0.84291128 1 0.036590154 0.026464137 50940 phosphodiesterase 11A "GO:0004112,GO:0004114,GO:0004115,GO:0004118,GO:0005575,GO:0005829,GO:0007165,GO:0007186,GO:0008152,GO:0010754,GO:0030553,GO:0043951,GO:0046872,GO:0047555" "cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|cellular_component|cytosol|signal transduction|G protein-coupled receptor signaling pathway|metabolic process|negative regulation of cGMP-mediated signaling|cGMP binding|negative regulation of cAMP-mediated signaling|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity" "hsa00230,hsa04934,hsa05032" Purine metabolism|Cushing syndrome|Morphine addiction PDE12 845.7760183 904.3257678 787.2262688 0.870511819 -0.20006421 0.583142021 1 4.231030935 3.841818134 201626 phosphodiesterase 12 "GO:0000175,GO:0000288,GO:0000958,GO:0004527,GO:0004535,GO:0005739,GO:0005759,GO:0005829,GO:0006397,GO:0034611,GO:0035457,GO:0044528,GO:0045070,GO:0046872,GO:0051607,GO:0060548,GO:0071346,GO:0071359,GO:0090305,GO:0090324,GO:0090503" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|mitochondrial mRNA catabolic process|exonuclease activity|poly(A)-specific ribonuclease activity|mitochondrion|mitochondrial matrix|cytosol|mRNA processing|oligoribonucleotidase activity|cellular response to interferon-alpha|regulation of mitochondrial mRNA stability|positive regulation of viral genome replication|metal ion binding|defense response to virus|negative regulation of cell death|cellular response to interferon-gamma|cellular response to dsRNA|nucleic acid phosphodiester bond hydrolysis|negative regulation of oxidative phosphorylation|RNA phosphodiester bond hydrolysis, exonucleolytic" PDE2A 86.88537733 147.1686154 26.60213925 0.180759595 -2.467855869 0.001012067 0.091450389 1.555095179 0.293206952 5138 phosphodiesterase 2A "GO:0000122,GO:0000287,GO:0003170,GO:0003281,GO:0004114,GO:0004115,GO:0004118,GO:0005515,GO:0005634,GO:0005737,GO:0005741,GO:0005743,GO:0005759,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0007165,GO:0007186,GO:0007193,GO:0008270,GO:0010628,GO:0010752,GO:0010754,GO:0010821,GO:0019933,GO:0019934,GO:0030552,GO:0030553,GO:0030911,GO:0035904,GO:0036006,GO:0042301,GO:0042734,GO:0042803,GO:0043116,GO:0043117,GO:0043949,GO:0043951,GO:0046069,GO:0047555,GO:0048471,GO:0050729,GO:0061028,GO:0071260,GO:0071320,GO:0071321,GO:0071560,GO:0097060,GO:1904613" "negative regulation of transcription by RNA polymerase II|magnesium ion binding|heart valve development|ventricular septum development|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|protein binding|nucleus|cytoplasm|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial matrix|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|zinc ion binding|positive regulation of gene expression|regulation of cGMP-mediated signaling|negative regulation of cGMP-mediated signaling|regulation of mitochondrion organization|cAMP-mediated signaling|cGMP-mediated signaling|cAMP binding|cGMP binding|TPR domain binding|aorta development|cellular response to macrophage colony-stimulating factor stimulus|phosphate ion binding|presynaptic membrane|protein homodimerization activity|negative regulation of vascular permeability|positive regulation of vascular permeability|regulation of cAMP-mediated signaling|negative regulation of cAMP-mediated signaling|cGMP catabolic process|3',5'-cyclic-GMP phosphodiesterase activity|perinuclear region of cytoplasm|positive regulation of inflammatory response|establishment of endothelial barrier|cellular response to mechanical stimulus|cellular response to cAMP|cellular response to cGMP|cellular response to transforming growth factor beta stimulus|synaptic membrane|cellular response to 2,3,7,8-tetrachlorodibenzodioxine" "hsa00230,hsa04022,hsa04740,hsa04925,hsa05032" Purine metabolism|cGMP-PKG signaling pathway|Olfactory transduction|Aldosterone synthesis and secretion|Morphine addiction PDE4A 8.030573092 10.14955968 5.911586499 0.582447582 -0.779799875 0.654071524 1 0.083003293 0.050427577 5141 phosphodiesterase 4A "GO:0004114,GO:0004115,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006198,GO:0007165,GO:0007186,GO:0007608,GO:0010738,GO:0016020,GO:0030552,GO:0032587,GO:0035690,GO:0043949,GO:0046872,GO:0048471" "3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|sensory perception of smell|regulation of protein kinase A signaling|membrane|cAMP binding|ruffle membrane|cellular response to drug|regulation of cAMP-mediated signaling|metal ion binding|perinuclear region of cytoplasm" "hsa00230,hsa04024,hsa04928,hsa05032" "Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction" PDE4B 30.55532109 34.50850292 26.60213925 0.770886506 -0.37540962 0.723930768 1 0.283861285 0.228250921 5142 phosphodiesterase 4B "GO:0000930,GO:0001780,GO:0004114,GO:0004115,GO:0005634,GO:0005813,GO:0005829,GO:0005891,GO:0006198,GO:0007165,GO:0007186,GO:0008021,GO:0014069,GO:0030018,GO:0030552,GO:0030593,GO:0032729,GO:0032743,GO:0035690,GO:0043015,GO:0043197,GO:0044325,GO:0046872,GO:0048471,GO:0050852,GO:0050900,GO:0060076,GO:0071222,GO:0071872,GO:0086004,GO:0140199,GO:1901841,GO:1901898" "gamma-tubulin complex|neutrophil homeostasis|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|nucleus|centrosome|cytosol|voltage-gated calcium channel complex|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|synaptic vesicle|postsynaptic density|Z disc|cAMP binding|neutrophil chemotaxis|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|cellular response to drug|gamma-tubulin binding|dendritic spine|ion channel binding|metal ion binding|perinuclear region of cytoplasm|T cell receptor signaling pathway|leukocyte migration|excitatory synapse|cellular response to lipopolysaccharide|cellular response to epinephrine stimulus|regulation of cardiac muscle cell contraction|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|regulation of high voltage-gated calcium channel activity|negative regulation of relaxation of cardiac muscle" "hsa00230,hsa04024,hsa04928,hsa05032" "Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction" PDE4C 9.04552906 12.17947162 5.911586499 0.485372985 -1.042834281 0.499104294 1 0.104461858 0.052887042 5143 phosphodiesterase 4C "GO:0004114,GO:0004115,GO:0005615,GO:0005634,GO:0005829,GO:0005929,GO:0006198,GO:0007165,GO:0007186,GO:0046872,GO:0048471" "3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|extracellular space|nucleus|cytosol|cilium|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|metal ion binding|perinuclear region of cytoplasm" "hsa00230,hsa04024,hsa04928,hsa05032" "Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction" PDE4D 279.3397834 337.9803375 220.6992293 0.652994286 -0.614857726 0.203983018 1 0.941712701 0.641421834 5144 phosphodiesterase 4D "GO:0002027,GO:0004114,GO:0004115,GO:0005515,GO:0005634,GO:0005815,GO:0005829,GO:0005886,GO:0005891,GO:0006198,GO:0007165,GO:0007186,GO:0010469,GO:0010880,GO:0016324,GO:0019899,GO:0019933,GO:0030552,GO:0031698,GO:0032729,GO:0032743,GO:0032754,GO:0033137,GO:0034704,GO:0043951,GO:0044325,GO:0045822,GO:0046872,GO:0048471,GO:0050852,GO:0051117,GO:0060314,GO:0061028,GO:0071875,GO:0086004,GO:0086024,GO:0097110,GO:1901363,GO:1901844,GO:1901898" "regulation of heart rate|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|protein binding|nucleus|microtubule organizing center|cytosol|plasma membrane|voltage-gated calcium channel complex|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|regulation of signaling receptor activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|apical plasma membrane|enzyme binding|cAMP-mediated signaling|cAMP binding|beta-2 adrenergic receptor binding|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of interleukin-5 production|negative regulation of peptidyl-serine phosphorylation|calcium channel complex|negative regulation of cAMP-mediated signaling|ion channel binding|negative regulation of heart contraction|metal ion binding|perinuclear region of cytoplasm|T cell receptor signaling pathway|ATPase binding|regulation of ryanodine-sensitive calcium-release channel activity|establishment of endothelial barrier|adrenergic receptor signaling pathway|regulation of cardiac muscle cell contraction|adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate|scaffold protein binding|heterocyclic compound binding|regulation of cell communication by electrical coupling involved in cardiac conduction|negative regulation of relaxation of cardiac muscle" "hsa00230,hsa04024,hsa04928,hsa05032" "Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction" PDE4DIP 3211.914008 3162.602797 3261.225219 1.031183942 0.044301702 0.890103116 1 11.16511046 12.00922814 9659 phosphodiesterase 4D interacting protein "GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0005813,GO:0019899,GO:0030016,GO:0034622,GO:0060090,GO:1903358" protein binding|nucleus|cytoplasm|Golgi apparatus|centrosome|enzyme binding|myofibril|cellular protein-containing complex assembly|molecular adaptor activity|regulation of Golgi organization PDE5A 74.17417938 52.77771036 95.57064841 1.810814599 0.856638843 0.253678939 1 0.354886463 0.670315637 8654 phosphodiesterase 5A "GO:0004114,GO:0005515,GO:0005575,GO:0005829,GO:0007165,GO:0030553,GO:0046069,GO:0046872,GO:0047555" "3',5'-cyclic-nucleotide phosphodiesterase activity|protein binding|cellular_component|cytosol|signal transduction|cGMP binding|cGMP catabolic process|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity" "hsa00230,hsa04022" Purine metabolism|cGMP-PKG signaling pathway PDE6B 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.023354811 0 5158 phosphodiesterase 6B "GO:0004114,GO:0005886,GO:0007165,GO:0007223,GO:0007601,GO:0007603,GO:0016056,GO:0022400,GO:0042622,GO:0043153,GO:0046872,GO:0047555,GO:0060041,GO:0097381" "3',5'-cyclic-nucleotide phosphodiesterase activity|plasma membrane|signal transduction|Wnt signaling pathway, calcium modulating pathway|visual perception|phototransduction, visible light|rhodopsin mediated signaling pathway|regulation of rhodopsin mediated signaling pathway|photoreceptor outer segment membrane|entrainment of circadian clock by photoperiod|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|retina development in camera-type eye|photoreceptor disc membrane" "hsa00230,hsa04744" Purine metabolism|Phototransduction PDE6D 326.2316394 310.5765263 341.8867525 1.100813241 0.138569729 0.768487357 1 9.492821611 10.89995975 5147 phosphodiesterase 6D "GO:0005095,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005929,GO:0007601,GO:0030659,GO:0031267,GO:0031410,GO:0034260,GO:0050896" GTPase inhibitor activity|protein binding|cytoplasm|cytosol|cytoskeleton|cilium|visual perception|cytoplasmic vesicle membrane|small GTPase binding|cytoplasmic vesicle|negative regulation of GTPase activity|response to stimulus hsa00230 Purine metabolism PDE6G 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.184574288 0.046723217 5148 phosphodiesterase 6G "GO:0000187,GO:0004857,GO:0005515,GO:0005886,GO:0007223,GO:0007601,GO:0016056,GO:0022400,GO:0030507,GO:0030553,GO:0042622,GO:0043086,GO:0045742,GO:0045745,GO:0047555,GO:0097381" "activation of MAPK activity|enzyme inhibitor activity|protein binding|plasma membrane|Wnt signaling pathway, calcium modulating pathway|visual perception|rhodopsin mediated signaling pathway|regulation of rhodopsin mediated signaling pathway|spectrin binding|cGMP binding|photoreceptor outer segment membrane|negative regulation of catalytic activity|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of G protein-coupled receptor signaling pathway|3',5'-cyclic-GMP phosphodiesterase activity|photoreceptor disc membrane" "hsa00230,hsa04744" Purine metabolism|Phototransduction PDE7A 653.8263686 748.0225487 559.6301886 0.748146148 -0.418607971 0.27506861 1 5.299301053 4.135432786 5150 phosphodiesterase 7A "GO:0004114,GO:0004115,GO:0005829,GO:0006198,GO:0007165,GO:0007186,GO:0019933,GO:0046872" "3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cytosol|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|cAMP-mediated signaling|metal ion binding" "hsa00230,hsa05032" Purine metabolism|Morphine addiction PDE8A 2426.026827 2849.996359 2002.057294 0.702477141 -0.509476815 0.110989222 1 25.23907351 18.49360319 5151 phosphodiesterase 8A "GO:0001934,GO:0004114,GO:0004115,GO:0005829,GO:0006198,GO:0006355,GO:0007165,GO:0007186,GO:0019900,GO:0046872,GO:0047555,GO:0060548,GO:0070062,GO:0070374,GO:0071364,GO:1903206" "positive regulation of protein phosphorylation|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cytosol|cAMP catabolic process|regulation of transcription, DNA-templated|signal transduction|G protein-coupled receptor signaling pathway|kinase binding|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|negative regulation of cell death|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|negative regulation of hydrogen peroxide-induced cell death" "hsa00230,hsa04927,hsa04934,hsa05032" Purine metabolism|Cortisol synthesis and secretion|Cushing syndrome|Morphine addiction PDE8B 34.8405532 24.35894324 45.32216316 1.860596443 0.895765174 0.347764637 1 0.231288816 0.44887224 8622 phosphodiesterase 8B "GO:0004114,GO:0004115,GO:0005575,GO:0005829,GO:0006198,GO:0007165,GO:0007186,GO:0046872" "3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cellular_component|cytosol|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|metal ion binding" "hsa00230,hsa04927,hsa04934,hsa05032" Purine metabolism|Cortisol synthesis and secretion|Cushing syndrome|Morphine addiction PDF 54.00595039 54.80762229 53.20427849 0.970745971 -0.042834281 0.983842172 1 0.970903365 0.983099629 64146 "peptide deformylase, mitochondrial" "GO:0005739,GO:0006412,GO:0008284,GO:0018206,GO:0031365,GO:0042586,GO:0043686,GO:0046872" mitochondrion|translation|positive regulation of cell population proliferation|peptidyl-methionine modification|N-terminal protein amino acid modification|peptide deformylase activity|co-translational protein modification|metal ion binding PDGFA 743.6366099 724.6785614 762.5946584 1.052321262 0.073575211 0.846719319 1 10.98217014 12.05458998 5154 platelet derived growth factor subunit A "GO:0000139,GO:0000165,GO:0001525,GO:0001775,GO:0001942,GO:0002053,GO:0002576,GO:0005161,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005902,GO:0007267,GO:0008083,GO:0008284,GO:0009611,GO:0009887,GO:0009986,GO:0010512,GO:0010544,GO:0014068,GO:0014910,GO:0030031,GO:0030036,GO:0030198,GO:0030335,GO:0031093,GO:0031954,GO:0032956,GO:0035793,GO:0042060,GO:0042803,GO:0043406,GO:0043410,GO:0043588,GO:0046982,GO:0048008,GO:0048146,GO:0048286,GO:0048407,GO:0050730,GO:0050919,GO:0051781,GO:0051897,GO:0060683,GO:0070374,GO:0070851,GO:0072124,GO:1990401,GO:2000278" Golgi membrane|MAPK cascade|angiogenesis|cell activation|hair follicle development|positive regulation of mesenchymal cell proliferation|platelet degranulation|platelet-derived growth factor receptor binding|protein binding|collagen binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|microvillus|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|response to wounding|animal organ morphogenesis|cell surface|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of smooth muscle cell migration|cell projection assembly|actin cytoskeleton organization|extracellular matrix organization|positive regulation of cell migration|platelet alpha granule lumen|positive regulation of protein autophosphorylation|regulation of actin cytoskeleton organization|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|wound healing|protein homodimerization activity|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|skin development|protein heterodimerization activity|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|lung alveolus development|platelet-derived growth factor binding|regulation of peptidyl-tyrosine phosphorylation|negative chemotaxis|positive regulation of cell division|positive regulation of protein kinase B signaling|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|positive regulation of ERK1 and ERK2 cascade|growth factor receptor binding|regulation of glomerular mesangial cell proliferation|embryonic lung development|regulation of DNA biosynthetic process "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05200,hsa05202,hsa05206,hsa05214,hsa05215,hsa05218,hsa05231,hsa05418" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Transcriptional misregulation in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PDGFB 1340.804831 1539.688204 1141.921459 0.7416576 -0.4311748 0.200223703 1 20.61321064 15.94648698 5155 platelet derived growth factor subunit B "GO:0000139,GO:0000165,GO:0001892,GO:0001938,GO:0002548,GO:0002576,GO:0003104,GO:0005161,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005737,GO:0005788,GO:0005796,GO:0006468,GO:0007507,GO:0008083,GO:0008284,GO:0009611,GO:0009986,GO:0010512,GO:0010544,GO:0010628,GO:0010629,GO:0010811,GO:0014068,GO:0014911,GO:0016176,GO:0016323,GO:0018105,GO:0018108,GO:0030097,GO:0030198,GO:0030335,GO:0031093,GO:0031954,GO:0032091,GO:0032147,GO:0032148,GO:0035655,GO:0035793,GO:0038001,GO:0042056,GO:0042802,GO:0042803,GO:0043406,GO:0043410,GO:0043536,GO:0043552,GO:0045737,GO:0045840,GO:0045892,GO:0045893,GO:0046982,GO:0048008,GO:0048146,GO:0048407,GO:0048661,GO:0050731,GO:0050918,GO:0050921,GO:0051781,GO:0051897,GO:0060326,GO:0061098,GO:0062023,GO:0070374,GO:0070528,GO:0070851,GO:0071363,GO:0071506,GO:0072126,GO:0072255,GO:0072593,GO:0090280,GO:1900127,GO:1902894,GO:1902895,GO:1904707,GO:1904754,GO:1905064,GO:1905176,GO:2000379,GO:2000573,GO:2000591" "Golgi membrane|MAPK cascade|embryonic placenta development|positive regulation of endothelial cell proliferation|monocyte chemotaxis|platelet degranulation|positive regulation of glomerular filtration|platelet-derived growth factor receptor binding|protein binding|collagen binding|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum lumen|Golgi lumen|protein phosphorylation|heart development|growth factor activity|positive regulation of cell population proliferation|response to wounding|cell surface|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell-substrate adhesion|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of smooth muscle cell migration|superoxide-generating NADPH oxidase activator activity|basolateral plasma membrane|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|hemopoiesis|extracellular matrix organization|positive regulation of cell migration|platelet alpha granule lumen|positive regulation of protein autophosphorylation|negative regulation of protein binding|activation of protein kinase activity|activation of protein kinase B activity|interleukin-18-mediated signaling pathway|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|paracrine signaling|chemoattractant activity|identical protein binding|protein homodimerization activity|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of mitotic nuclear division|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein heterodimerization activity|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|platelet-derived growth factor binding|positive regulation of smooth muscle cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of chemotaxis|positive regulation of cell division|positive regulation of protein kinase B signaling|cell chemotaxis|positive regulation of protein tyrosine kinase activity|collagen-containing extracellular matrix|positive regulation of ERK1 and ERK2 cascade|protein kinase C signaling|growth factor receptor binding|cellular response to growth factor stimulus|cellular response to mycophenolic acid|positive regulation of glomerular mesangial cell proliferation|metanephric glomerular mesangial cell development|reactive oxygen species metabolic process|positive regulation of calcium ion import|positive regulation of hyaluronan biosynthetic process|negative regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration|negative regulation of vascular associated smooth muscle cell differentiation|positive regulation of vascular associated smooth muscle cell dedifferentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of DNA biosynthetic process|positive regulation of metanephric mesenchymal cell migration" "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05167,hsa05200,hsa05206,hsa05211,hsa05214,hsa05215,hsa05218,hsa05231,hsa05418" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|MicroRNAs in cancer|Renal cell carcinoma|Glioma|Prostate cancer|Melanoma|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PDGFC 705.4070144 704.3794421 706.4345867 1.002917667 0.004203175 0.995406474 1 8.7372848 9.140242194 56034 platelet derived growth factor C "GO:0000139,GO:0005161,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005788,GO:0005829,GO:0005886,GO:0007171,GO:0007417,GO:0008083,GO:0008284,GO:0009887,GO:0009986,GO:0014068,GO:0030335,GO:0031954,GO:0042803,GO:0043406,GO:0048008,GO:0048146,GO:0048565,GO:0048568,GO:0050730,GO:0051781,GO:0060348,GO:0070062,GO:0070374,GO:0070851,GO:0071230,GO:0120162" Golgi membrane|platelet-derived growth factor receptor binding|protein binding|extracellular region|extracellular space|nucleus|endoplasmic reticulum lumen|cytosol|plasma membrane|activation of transmembrane receptor protein tyrosine kinase activity|central nervous system development|growth factor activity|positive regulation of cell population proliferation|animal organ morphogenesis|cell surface|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of cell migration|positive regulation of protein autophosphorylation|protein homodimerization activity|positive regulation of MAP kinase activity|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|digestive tract development|embryonic organ development|regulation of peptidyl-tyrosine phosphorylation|positive regulation of cell division|bone development|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|growth factor receptor binding|cellular response to amino acid stimulus|positive regulation of cold-induced thermogenesis "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04810,hsa05215,hsa05218,hsa05231" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Regulation of actin cytoskeleton|Prostate cancer|Melanoma|Choline metabolism in cancer PDGFD 47.94590613 44.65806261 51.23374966 1.147245238 0.198173818 0.838526397 1 0.589310403 0.705206491 80310 platelet derived growth factor D "GO:0000139,GO:0005161,GO:0005576,GO:0005615,GO:0005788,GO:0007275,GO:0008083,GO:0008284,GO:0014068,GO:0030335,GO:0031954,GO:0036120,GO:0043406,GO:0048008,GO:0048146,GO:0048661,GO:0050730,GO:0051781,GO:0070301,GO:0070374,GO:0070851,GO:0071230,GO:0071560,GO:0071673,GO:0072126,GO:2000439" Golgi membrane|platelet-derived growth factor receptor binding|extracellular region|extracellular space|endoplasmic reticulum lumen|multicellular organism development|growth factor activity|positive regulation of cell population proliferation|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of cell migration|positive regulation of protein autophosphorylation|cellular response to platelet-derived growth factor stimulus|positive regulation of MAP kinase activity|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of smooth muscle cell proliferation|regulation of peptidyl-tyrosine phosphorylation|positive regulation of cell division|cellular response to hydrogen peroxide|positive regulation of ERK1 and ERK2 cascade|growth factor receptor binding|cellular response to amino acid stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of smooth muscle cell chemotaxis|positive regulation of glomerular mesangial cell proliferation|positive regulation of monocyte extravasation "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04810,hsa05215,hsa05218,hsa05231" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Regulation of actin cytoskeleton|Prostate cancer|Melanoma|Choline metabolism in cancer PDGFRA 8.075110419 13.19442759 2.95579325 0.224018301 -2.158311499 0.176784179 1 0.082837636 0.019356513 5156 platelet derived growth factor receptor alpha "GO:0000165,GO:0001553,GO:0001701,GO:0001775,GO:0002244,GO:0004672,GO:0004714,GO:0005018,GO:0005021,GO:0005161,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0005902,GO:0005929,GO:0007169,GO:0007204,GO:0007275,GO:0008210,GO:0008284,GO:0009897,GO:0010544,GO:0010863,GO:0014068,GO:0016020,GO:0016032,GO:0018108,GO:0019838,GO:0023019,GO:0030054,GO:0030198,GO:0030324,GO:0030325,GO:0030335,GO:0030539,GO:0031226,GO:0032991,GO:0033327,GO:0033674,GO:0034614,GO:0035790,GO:0038085,GO:0038091,GO:0042060,GO:0042475,GO:0042803,GO:0043235,GO:0043552,GO:0044877,GO:0046777,GO:0048008,GO:0048015,GO:0048146,GO:0048407,GO:0048557,GO:0048701,GO:0048704,GO:0050872,GO:0050920,GO:0051897,GO:0055003,GO:0060021,GO:0060325,GO:0060326,GO:0061298,GO:0070374,GO:0070527,GO:0071230,GO:0072277,GO:2000249,GO:2000739" MAPK cascade|luteinization|in utero embryonic development|cell activation|hematopoietic progenitor cell differentiation|protein kinase activity|transmembrane receptor protein tyrosine kinase activity|platelet-derived growth factor alpha-receptor activity|vascular endothelial growth factor-activated receptor activity|platelet-derived growth factor receptor binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|microvillus|cilium|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of cytosolic calcium ion concentration|multicellular organism development|estrogen metabolic process|positive regulation of cell population proliferation|external side of plasma membrane|negative regulation of platelet activation|positive regulation of phospholipase C activity|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|viral process|peptidyl-tyrosine phosphorylation|growth factor binding|signal transduction involved in regulation of gene expression|cell junction|extracellular matrix organization|lung development|adrenal gland development|positive regulation of cell migration|male genitalia development|intrinsic component of plasma membrane|protein-containing complex|Leydig cell differentiation|positive regulation of kinase activity|cellular response to reactive oxygen species|platelet-derived growth factor receptor-alpha signaling pathway|vascular endothelial growth factor binding|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|wound healing|odontogenesis of dentin-containing tooth|protein homodimerization activity|receptor complex|positive regulation of phosphatidylinositol 3-kinase activity|protein-containing complex binding|protein autophosphorylation|platelet-derived growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of fibroblast proliferation|platelet-derived growth factor binding|embryonic digestive tract morphogenesis|embryonic cranial skeleton morphogenesis|embryonic skeletal system morphogenesis|white fat cell differentiation|regulation of chemotaxis|positive regulation of protein kinase B signaling|cardiac myofibril assembly|roof of mouth development|face morphogenesis|cell chemotaxis|retina vasculature development in camera-type eye|positive regulation of ERK1 and ERK2 cascade|platelet aggregation|cellular response to amino acid stimulus|metanephric glomerular capillary formation|regulation of actin cytoskeleton reorganization|regulation of mesenchymal stem cell differentiation "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04144,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05163,hsa05200,hsa05206,hsa05214,hsa05215,hsa05218,hsa05230,hsa05231" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|Human cytomegalovirus infection|Pathways in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Central carbon metabolism in cancer|Choline metabolism in cancer PDGFRB 86.23488479 69.01700585 103.4527637 1.498945984 0.583948395 0.415198201 1 0.609603744 0.953124292 5159 platelet derived growth factor receptor beta "GO:0000165,GO:0004713,GO:0004714,GO:0004992,GO:0005017,GO:0005019,GO:0005102,GO:0005161,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0005925,GO:0006024,GO:0007165,GO:0007169,GO:0007186,GO:0007275,GO:0007568,GO:0008284,GO:0008584,GO:0009636,GO:0009986,GO:0010863,GO:0014068,GO:0014911,GO:0016020,GO:0016324,GO:0016477,GO:0018108,GO:0019838,GO:0019899,GO:0019901,GO:0030335,GO:0031226,GO:0031410,GO:0032355,GO:0032516,GO:0032526,GO:0032956,GO:0032967,GO:0033674,GO:0034405,GO:0035025,GO:0035441,GO:0035789,GO:0035791,GO:0035793,GO:0035909,GO:0036120,GO:0038085,GO:0038091,GO:0042060,GO:0042542,GO:0043065,GO:0043066,GO:0043202,GO:0043231,GO:0043235,GO:0043406,GO:0043548,GO:0043552,GO:0043627,GO:0045840,GO:0046488,GO:0046777,GO:0048008,GO:0048015,GO:0048146,GO:0048407,GO:0048661,GO:0048839,GO:0050921,GO:0051897,GO:0055003,GO:0055093,GO:0060326,GO:0060437,GO:0060981,GO:0061298,GO:0070374,GO:0071670,GO:0072075,GO:0072262,GO:0072277,GO:0072278,GO:0072284,GO:0090280,GO:2000379,GO:2000491,GO:2000573" MAPK cascade|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|platelet activating factor receptor activity|platelet-derived growth factor-activated receptor activity|platelet-derived growth factor beta-receptor activity|signaling receptor binding|platelet-derived growth factor receptor binding|protein binding|ATP binding|nucleus|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|focal adhesion|glycosaminoglycan biosynthetic process|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|G protein-coupled receptor signaling pathway|multicellular organism development|aging|positive regulation of cell population proliferation|male gonad development|response to toxic substance|cell surface|positive regulation of phospholipase C activity|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of smooth muscle cell migration|membrane|apical plasma membrane|cell migration|peptidyl-tyrosine phosphorylation|growth factor binding|enzyme binding|protein kinase binding|positive regulation of cell migration|intrinsic component of plasma membrane|cytoplasmic vesicle|response to estradiol|positive regulation of phosphoprotein phosphatase activity|response to retinoic acid|regulation of actin cytoskeleton organization|positive regulation of collagen biosynthetic process|positive regulation of kinase activity|response to fluid shear stress|positive regulation of Rho protein signal transduction|cell migration involved in vasculogenesis|metanephric mesenchymal cell migration|platelet-derived growth factor receptor-beta signaling pathway|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|aorta morphogenesis|cellular response to platelet-derived growth factor stimulus|vascular endothelial growth factor binding|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|wound healing|response to hydrogen peroxide|positive regulation of apoptotic process|negative regulation of apoptotic process|lysosomal lumen|intracellular membrane-bounded organelle|receptor complex|positive regulation of MAP kinase activity|phosphatidylinositol 3-kinase binding|positive regulation of phosphatidylinositol 3-kinase activity|response to estrogen|positive regulation of mitotic nuclear division|phosphatidylinositol metabolic process|protein autophosphorylation|platelet-derived growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of fibroblast proliferation|platelet-derived growth factor binding|positive regulation of smooth muscle cell proliferation|inner ear development|positive regulation of chemotaxis|positive regulation of protein kinase B signaling|cardiac myofibril assembly|response to hyperoxia|cell chemotaxis|lung growth|cell migration involved in coronary angiogenesis|retina vasculature development in camera-type eye|positive regulation of ERK1 and ERK2 cascade|smooth muscle cell chemotaxis|metanephric mesenchyme development|metanephric glomerular mesangial cell proliferation involved in metanephros development|metanephric glomerular capillary formation|metanephric comma-shaped body morphogenesis|metanephric S-shaped body morphogenesis|positive regulation of calcium ion import|positive regulation of reactive oxygen species metabolic process|positive regulation of hepatic stellate cell activation|positive regulation of DNA biosynthetic process "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05165,hsa05200,hsa05206,hsa05214,hsa05215,hsa05218,hsa05230,hsa05231" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Central carbon metabolism in cancer|Choline metabolism in cancer PDGFRL 82.96188704 114.6900244 51.23374966 0.44671496 -1.162573526 0.108688117 1 3.031651949 1.412621353 5157 platelet derived growth factor receptor like "GO:0004992,GO:0005019,GO:0005575,GO:0005576,GO:0007186,GO:0008150,GO:0035791" platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|cellular_component|extracellular region|G protein-coupled receptor signaling pathway|biological_process|platelet-derived growth factor receptor-beta signaling pathway PDHA1 2306.838532 2313.084652 2300.592413 0.994599316 -0.007812656 0.982018559 1 33.74123777 35.00459814 5160 pyruvate dehydrogenase E1 subunit alpha 1 "GO:0004739,GO:0005515,GO:0005634,GO:0005730,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006086,GO:0006090,GO:0006099,GO:0034604,GO:0045254,GO:0061732" pyruvate dehydrogenase (acetyl-transferring) activity|protein binding|nucleus|nucleolus|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|acetyl-CoA biosynthetic process from pyruvate|pyruvate metabolic process|tricarboxylic acid cycle|pyruvate dehydrogenase (NAD+) activity|pyruvate dehydrogenase complex|mitochondrial acetyl-CoA biosynthetic process from pyruvate "hsa00010,hsa00020,hsa00620,hsa04066,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PDHB 1342.822865 1138.780597 1546.865134 1.358352205 0.441857602 0.189258106 1 38.27154601 54.22559524 5162 pyruvate dehydrogenase E1 subunit beta "GO:0004739,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006086,GO:0006090,GO:0006099,GO:0034604,GO:0045254,GO:0061732" pyruvate dehydrogenase (acetyl-transferring) activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|acetyl-CoA biosynthetic process from pyruvate|pyruvate metabolic process|tricarboxylic acid cycle|pyruvate dehydrogenase (NAD+) activity|pyruvate dehydrogenase complex|mitochondrial acetyl-CoA biosynthetic process from pyruvate "hsa00010,hsa00020,hsa00620,hsa04066,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PDHX 867.8850846 900.2659439 835.5042252 0.928063791 -0.107704121 0.768064469 1 17.14753445 16.59951667 8050 pyruvate dehydrogenase complex component X "GO:0005515,GO:0005739,GO:0005759,GO:0006090,GO:0016746,GO:0034604,GO:0045254,GO:0061732" "protein binding|mitochondrion|mitochondrial matrix|pyruvate metabolic process|transferase activity, transferring acyl groups|pyruvate dehydrogenase (NAD+) activity|pyruvate dehydrogenase complex|mitochondrial acetyl-CoA biosynthetic process from pyruvate" "hsa00010,hsa00020,hsa00620" Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism PDIA3 11500.23172 12106.39479 10894.06865 0.89986068 -0.152226439 0.655097779 1 166.6158118 156.3894379 2923 protein disulfide isomerase family A member 3 "GO:0002474,GO:0002479,GO:0003723,GO:0003756,GO:0004197,GO:0004629,GO:0005515,GO:0005615,GO:0005634,GO:0005783,GO:0005788,GO:0005925,GO:0006457,GO:0006508,GO:0009986,GO:0015036,GO:0015037,GO:0018215,GO:0034975,GO:0034976,GO:0042470,GO:0042802,GO:0042824,GO:0045335,GO:0055038,GO:0055114,GO:0070062,GO:0098761,GO:2001238" "antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|RNA binding|protein disulfide isomerase activity|cysteine-type endopeptidase activity|phospholipase C activity|protein binding|extracellular space|nucleus|endoplasmic reticulum|endoplasmic reticulum lumen|focal adhesion|protein folding|proteolysis|cell surface|disulfide oxidoreductase activity|peptide disulfide oxidoreductase activity|protein phosphopantetheinylation|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|melanosome|identical protein binding|MHC class I peptide loading complex|phagocytic vesicle|recycling endosome membrane|oxidation-reduction process|extracellular exosome|cellular response to interleukin-7|positive regulation of extrinsic apoptotic signaling pathway" "hsa04141,hsa04612,hsa05163,hsa05168,hsa05169,hsa05170" Protein processing in endoplasmic reticulum|Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection PDIA4 9594.787494 11403.0303 7786.544684 0.682848723 -0.550362092 0.101486874 1 206.8493042 147.3311219 9601 protein disulfide isomerase family A member 4 "GO:0003723,GO:0003756,GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0006457,GO:0009306,GO:0009986,GO:0015037,GO:0018215,GO:0034976,GO:0042470,GO:0055114,GO:0061077" RNA binding|protein disulfide isomerase activity|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|protein secretion|cell surface|peptide disulfide oxidoreductase activity|protein phosphopantetheinylation|response to endoplasmic reticulum stress|melanosome|oxidation-reduction process|chaperone-mediated protein folding "hsa04141,hsa04918,hsa05110" Protein processing in endoplasmic reticulum|Thyroid hormone synthesis|Vibrio cholerae infection PDIA5 1298.044553 1243.321061 1352.768044 1.088027933 0.121715595 0.720185404 1 34.14849543 38.75498279 10954 protein disulfide isomerase family A member 5 "GO:0003756,GO:0005515,GO:0005788,GO:0005789,GO:0006457,GO:0015037,GO:0016491,GO:0018215,GO:0036498,GO:0055114" protein disulfide isomerase activity|protein binding|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein folding|peptide disulfide oxidoreductase activity|oxidoreductase activity|protein phosphopantetheinylation|IRE1-mediated unfolded protein response|oxidation-reduction process PDIA6 6232.767137 7172.693828 5292.840446 0.73791529 -0.438472885 0.177920261 1 114.9957704 88.51243857 10130 protein disulfide isomerase family A member 6 "GO:0003756,GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0005789,GO:0005793,GO:0005829,GO:0005886,GO:0006457,GO:0015037,GO:0018215,GO:0034663,GO:0036498,GO:0042470,GO:0043687,GO:0044267,GO:0055114,GO:0070062" protein disulfide isomerase activity|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|protein folding|peptide disulfide oxidoreductase activity|protein phosphopantetheinylation|endoplasmic reticulum chaperone complex|IRE1-mediated unfolded protein response|melanosome|post-translational protein modification|cellular protein metabolic process|oxidation-reduction process|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum PDIK1L 92.02498348 94.39090506 89.65906191 0.949869713 -0.074198452 0.931263793 1 0.722795033 0.716135379 149420 PDLIM1 interacting kinase 1 like "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006468,GO:0051321,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|protein phosphorylation|meiotic cell cycle|protein serine kinase activity|protein threonine kinase activity PDK1 555.1136129 836.3237179 273.9035078 0.327508956 -1.610393736 7.68E-05 0.012957239 7.918647587 2.705142365 5163 pyruvate dehydrogenase kinase 1 "GO:0004672,GO:0004740,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006468,GO:0008283,GO:0008631,GO:0010510,GO:0010906,GO:0097411" protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|protein phosphorylation|cell population proliferation|intrinsic apoptotic signaling pathway in response to oxidative stress|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of glucose metabolic process|hypoxia-inducible factor-1alpha signaling pathway "hsa04066,hsa04360,hsa05230" HIF-1 signaling pathway|Axon guidance|Central carbon metabolism in cancer PDK2 718.9983185 623.1829646 814.8136725 1.307503123 0.386814393 0.303256946 1 8.312356781 11.33660044 5164 pyruvate dehydrogenase kinase 2 "GO:0004672,GO:0004740,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0005967,GO:0006006,GO:0006111,GO:0006468,GO:0006885,GO:0008286,GO:0010510,GO:0010565,GO:0010906,GO:0031670,GO:0034614,GO:0042593,GO:0042803,GO:0050848,GO:0072332" protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|regulation of gluconeogenesis|protein phosphorylation|regulation of pH|insulin receptor signaling pathway|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of cellular ketone metabolic process|regulation of glucose metabolic process|cellular response to nutrient|cellular response to reactive oxygen species|glucose homeostasis|protein homodimerization activity|regulation of calcium-mediated signaling|intrinsic apoptotic signaling pathway by p53 class mediator PDK3 864.5351364 974.3577296 754.7125431 0.774574389 -0.368524295 0.308634566 1 3.774497604 3.049567263 5165 pyruvate dehydrogenase kinase 3 "GO:0004672,GO:0004674,GO:0004740,GO:0005515,GO:0005524,GO:0005730,GO:0005739,GO:0005759,GO:0006006,GO:0006468,GO:0010510,GO:0010906,GO:0018105,GO:0035357,GO:0071333,GO:0071398,GO:0097411,GO:2000377" protein kinase activity|protein serine/threonine kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|protein binding|ATP binding|nucleolus|mitochondrion|mitochondrial matrix|glucose metabolic process|protein phosphorylation|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of glucose metabolic process|peptidyl-serine phosphorylation|peroxisome proliferator activated receptor signaling pathway|cellular response to glucose stimulus|cellular response to fatty acid|hypoxia-inducible factor-1alpha signaling pathway|regulation of reactive oxygen species metabolic process PDK4 102.135449 44.65806261 159.6128355 3.574110164 1.837584103 0.007891592 0.364181927 0.628095898 2.341584427 5166 pyruvate dehydrogenase kinase 4 "GO:0004672,GO:0004740,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006006,GO:0006468,GO:0006885,GO:0008286,GO:0009267,GO:0010510,GO:0010565,GO:0010906,GO:0042304,GO:0042593,GO:0042594,GO:0045124,GO:0046320,GO:0071398,GO:0072593,GO:2000811" protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|glucose metabolic process|protein phosphorylation|regulation of pH|insulin receptor signaling pathway|cellular response to starvation|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of cellular ketone metabolic process|regulation of glucose metabolic process|regulation of fatty acid biosynthetic process|glucose homeostasis|response to starvation|regulation of bone resorption|regulation of fatty acid oxidation|cellular response to fatty acid|reactive oxygen species metabolic process|negative regulation of anoikis PDLIM1 5789.081683 6106.990062 5471.173305 0.895887049 -0.158611242 0.624237146 1 215.6886349 201.5563337 9124 PDZ and LIM domain 1 "GO:0001666,GO:0001725,GO:0003713,GO:0003779,GO:0005515,GO:0005667,GO:0005737,GO:0005856,GO:0005912,GO:0005925,GO:0006357,GO:0006979,GO:0007507,GO:0010761,GO:0030011,GO:0030018,GO:0030036,GO:0030950,GO:0031941,GO:0043149,GO:0045893,GO:0046872,GO:0051371,GO:0061061,GO:0098609,GO:0098641" "response to hypoxia|stress fiber|transcription coactivator activity|actin binding|protein binding|transcription regulator complex|cytoplasm|cytoskeleton|adherens junction|focal adhesion|regulation of transcription by RNA polymerase II|response to oxidative stress|heart development|fibroblast migration|maintenance of cell polarity|Z disc|actin cytoskeleton organization|establishment or maintenance of actin cytoskeleton polarity|filamentous actin|stress fiber assembly|positive regulation of transcription, DNA-templated|metal ion binding|muscle alpha-actinin binding|muscle structure development|cell-cell adhesion|cadherin binding involved in cell-cell adhesion" PDLIM2 658.6514919 707.42431 609.8786738 0.862111558 -0.214053528 0.577498 1 6.113043108 5.497140733 64236 PDZ and LIM domain 2 "GO:0001725,GO:0003779,GO:0005515,GO:0005634,GO:0005912,GO:0007507,GO:0030018,GO:0030036,GO:0031941,GO:0046872,GO:0051371,GO:0061061" stress fiber|actin binding|protein binding|nucleus|adherens junction|heart development|Z disc|actin cytoskeleton organization|filamentous actin|metal ion binding|muscle alpha-actinin binding|muscle structure development PDLIM3 172.9178645 134.9891438 210.8465851 1.561952163 0.64335027 0.255808055 1 2.286529739 3.725293657 27295 PDZ and LIM domain 3 "GO:0001725,GO:0003779,GO:0005515,GO:0005829,GO:0005912,GO:0007507,GO:0030018,GO:0030036,GO:0031941,GO:0046872,GO:0051371,GO:0061061" stress fiber|actin binding|protein binding|cytosol|adherens junction|heart development|Z disc|actin cytoskeleton organization|filamentous actin|metal ion binding|muscle alpha-actinin binding|muscle structure development PDLIM4 1099.42346 1068.748635 1130.098286 1.057403256 0.080525674 0.818504724 1 23.71969677 26.16168461 8572 PDZ and LIM domain 4 "GO:0001725,GO:0003779,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0005912,GO:0007507,GO:0019903,GO:0030018,GO:0030027,GO:0030036,GO:0031532,GO:0031901,GO:0031905,GO:0031941,GO:0034777,GO:0042803,GO:0043197,GO:0045211,GO:0046872,GO:0048471,GO:0051371,GO:0051393,GO:0055038,GO:0061061,GO:0098976" stress fiber|actin binding|protein binding|nucleus|cytoplasm|cytoskeleton|adherens junction|heart development|protein phosphatase binding|Z disc|lamellipodium|actin cytoskeleton organization|actin cytoskeleton reorganization|early endosome membrane|early endosome lumen|filamentous actin|recycling endosome lumen|protein homodimerization activity|dendritic spine|postsynaptic membrane|metal ion binding|perinuclear region of cytoplasm|muscle alpha-actinin binding|alpha-actinin binding|recycling endosome membrane|muscle structure development|excitatory chemical synaptic transmission PDLIM5 1635.843027 1401.654192 1870.031863 1.334160646 0.415932392 0.205213678 1 8.191650139 11.39975326 10611 PDZ and LIM domain 5 "GO:0001725,GO:0003779,GO:0005080,GO:0005515,GO:0005829,GO:0005912,GO:0007507,GO:0014069,GO:0015629,GO:0016020,GO:0030018,GO:0030036,GO:0031941,GO:0042805,GO:0042995,GO:0046872,GO:0047485,GO:0051371,GO:0051963,GO:0061001,GO:0061049,GO:0061061,GO:0098609,GO:0098641,GO:0098793" stress fiber|actin binding|protein kinase C binding|protein binding|cytosol|adherens junction|heart development|postsynaptic density|actin cytoskeleton|membrane|Z disc|actin cytoskeleton organization|filamentous actin|actinin binding|cell projection|metal ion binding|protein N-terminus binding|muscle alpha-actinin binding|regulation of synapse assembly|regulation of dendritic spine morphogenesis|cell growth involved in cardiac muscle cell development|muscle structure development|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|presynapse PDLIM7 2372.967047 2725.156775 2020.777318 0.741526996 -0.431428878 0.177157563 1 66.45140919 51.39810316 9260 PDZ and LIM domain 7 "GO:0001503,GO:0001725,GO:0001726,GO:0003779,GO:0005515,GO:0005654,GO:0005829,GO:0005912,GO:0005925,GO:0006898,GO:0007411,GO:0007507,GO:0015629,GO:0030018,GO:0030036,GO:0031941,GO:0045669,GO:0046872,GO:0051371,GO:0061061" ossification|stress fiber|ruffle|actin binding|protein binding|nucleoplasm|cytosol|adherens junction|focal adhesion|receptor-mediated endocytosis|axon guidance|heart development|actin cytoskeleton|Z disc|actin cytoskeleton organization|filamentous actin|positive regulation of osteoblast differentiation|metal ion binding|muscle alpha-actinin binding|muscle structure development PDP1 4387.85555 5016.927352 3758.783749 0.749220287 -0.416538131 0.192684784 1 55.91762141 43.69926651 54704 pyruvate dehydrogenase phosphatase catalytic subunit 1 "GO:0004722,GO:0004724,GO:0004741,GO:0005515,GO:0005739,GO:0005759,GO:0006470,GO:0010510,GO:0035970,GO:0046872,GO:1904184" protein serine/threonine phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|[pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein binding|mitochondrion|mitochondrial matrix|protein dephosphorylation|regulation of acetyl-CoA biosynthetic process from pyruvate|peptidyl-threonine dephosphorylation|metal ion binding|positive regulation of pyruvate dehydrogenase activity PDP2 353.9175203 384.668312 323.1667286 0.840117885 -0.251336315 0.578504582 1 2.749766122 2.40963863 57546 pyruvate dehyrogenase phosphatase catalytic subunit 2 "GO:0004724,GO:0004741,GO:0005739,GO:0005759,GO:0006470,GO:0010510,GO:0046872,GO:1904184" magnesium-dependent protein serine/threonine phosphatase activity|[pyruvate dehydrogenase (lipoamide)] phosphatase activity|mitochondrion|mitochondrial matrix|protein dephosphorylation|regulation of acetyl-CoA biosynthetic process from pyruvate|metal ion binding|positive regulation of pyruvate dehydrogenase activity PDPK1 1177.843778 1041.344824 1314.342732 1.262158991 0.335893654 0.327679889 1 4.310972835 5.675515072 5170 3-phosphoinositide dependent protein kinase 1 "GO:0002223,GO:0003323,GO:0004674,GO:0004676,GO:0005158,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006468,GO:0006469,GO:0006972,GO:0007173,GO:0010518,GO:0010667,GO:0014069,GO:0016004,GO:0016020,GO:0016477,GO:0018105,GO:0018107,GO:0019722,GO:0019901,GO:0030036,GO:0030168,GO:0030512,GO:0031295,GO:0031410,GO:0032148,GO:0032869,GO:0034122,GO:0035556,GO:0038095,GO:0042995,GO:0043122,GO:0043204,GO:0043274,GO:0043304,GO:0043524,GO:0043536,GO:0045766,GO:0046777,GO:0048041,GO:0050852,GO:0051281,GO:0071364,GO:0097191,GO:0106310,GO:0106311,GO:1903078,GO:1903672,GO:1905564,GO:1990416,GO:2000352" stimulatory C-type lectin receptor signaling pathway|type B pancreatic cell development|protein serine/threonine kinase activity|3-phosphoinositide-dependent protein kinase activity|insulin receptor binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|protein phosphorylation|negative regulation of protein kinase activity|hyperosmotic response|epidermal growth factor receptor signaling pathway|positive regulation of phospholipase activity|negative regulation of cardiac muscle cell apoptotic process|postsynaptic density|phospholipase activator activity|membrane|cell migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|calcium-mediated signaling|protein kinase binding|actin cytoskeleton organization|platelet activation|negative regulation of transforming growth factor beta receptor signaling pathway|T cell costimulation|cytoplasmic vesicle|activation of protein kinase B activity|cellular response to insulin stimulus|negative regulation of toll-like receptor signaling pathway|intracellular signal transduction|Fc-epsilon receptor signaling pathway|cell projection|regulation of I-kappaB kinase/NF-kappaB signaling|perikaryon|phospholipase binding|regulation of mast cell degranulation|negative regulation of neuron apoptotic process|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|protein autophosphorylation|focal adhesion assembly|T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|cellular response to epidermal growth factor stimulus|extrinsic apoptotic signaling pathway|protein serine kinase activity|protein threonine kinase activity|positive regulation of protein localization to plasma membrane|positive regulation of sprouting angiogenesis|positive regulation of vascular endothelial cell proliferation|cellular response to brain-derived neurotrophic factor stimulus|negative regulation of endothelial cell apoptotic process "hsa01524,hsa03320,hsa04068,hsa04071,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04510,hsa04660,hsa04664,hsa04722,hsa04910,hsa04919,hsa04931,hsa04960,hsa05145,hsa05205,hsa05213,hsa05215,hsa05223,hsa05231" Platinum drug resistance|PPAR signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Focal adhesion|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Neurotrophin signaling pathway|Insulin signaling pathway|Thyroid hormone signaling pathway|Insulin resistance|Aldosterone-regulated sodium reabsorption|Toxoplasmosis|Proteoglycans in cancer|Endometrial cancer|Prostate cancer|Non-small cell lung cancer|Choline metabolism in cancer PDPR 1212.02023 1155.019892 1269.020569 1.098700185 0.135797755 0.692245404 1 4.987439924 5.715744467 55066 pyruvate dehydrogenase phosphatase regulatory subunit "GO:0005737,GO:0005739,GO:0005759,GO:0010510,GO:0016491,GO:0055114" cytoplasm|mitochondrion|mitochondrial matrix|regulation of acetyl-CoA biosynthetic process from pyruvate|oxidoreductase activity|oxidation-reduction process PDRG1 859.8896463 825.1592023 894.6200902 1.084178771 0.116602664 0.749698207 1 21.35483015 24.14976732 81572 p53 and DNA damage regulated 1 "GO:0005515,GO:0005737,GO:0006457,GO:0016272,GO:0051082" protein binding|cytoplasm|protein folding|prefoldin complex|unfolded protein binding PDS5A 3362.122294 3159.55793 3564.686659 1.128223232 0.17405255 0.584488608 1 21.00281702 24.71658791 23244 PDS5 cohesin associated factor A "GO:0000775,GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0005886,GO:0006281,GO:0007064,GO:0008156,GO:0051301" "chromosome, centromeric region|chromatin|protein binding|nucleus|nucleoplasm|chromosome|cytosol|plasma membrane|DNA repair|mitotic sister chromatid cohesion|negative regulation of DNA replication|cell division" PDS5B 1124.735255 1148.930156 1100.540353 0.957882729 -0.062079054 0.859693222 1 9.529849202 9.521695768 23047 PDS5 cohesin associated factor B "GO:0000775,GO:0000785,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006281,GO:0007064,GO:0008283,GO:0008285,GO:0042127,GO:0051301" "chromosome, centromeric region|chromatin|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|DNA repair|mitotic sister chromatid cohesion|cell population proliferation|negative regulation of cell population proliferation|regulation of cell population proliferation|cell division" PDSS1 208.0795815 248.6642123 167.4949508 0.673578837 -0.570081284 0.284606771 1 3.11115739 2.185880146 23590 decaprenyl diphosphate synthase subunit 1 "GO:0000010,GO:0004659,GO:0005515,GO:0005759,GO:0006744,GO:0008299,GO:0046872,GO:0046982,GO:0050347,GO:0097269,GO:1990234" trans-hexaprenyltranstransferase activity|prenyltransferase activity|protein binding|mitochondrial matrix|ubiquinone biosynthetic process|isoprenoid biosynthetic process|metal ion binding|protein heterodimerization activity|trans-octaprenyltranstransferase activity|all-trans-decaprenyl-diphosphate synthase activity|transferase complex hsa00900 Terpenoid backbone biosynthesis PDSS2 201.33391 225.320225 177.347595 0.787091327 -0.345397051 0.523675656 1 2.479181949 2.035398537 57107 decaprenyl diphosphate synthase subunit 2 "GO:0000010,GO:0004659,GO:0005515,GO:0005759,GO:0005829,GO:0006744,GO:0008299,GO:0021549,GO:0046982,GO:0050347,GO:0050878,GO:0097269,GO:1990234" trans-hexaprenyltranstransferase activity|prenyltransferase activity|protein binding|mitochondrial matrix|cytosol|ubiquinone biosynthetic process|isoprenoid biosynthetic process|cerebellum development|protein heterodimerization activity|trans-octaprenyltranstransferase activity|regulation of body fluid levels|all-trans-decaprenyl-diphosphate synthase activity|transferase complex hsa00900 Terpenoid backbone biosynthesis PDXDC1 2109.72775 2107.04859 2112.406909 1.002543045 0.003664181 0.99257451 1 17.50280103 18.30317845 23042 pyridoxal dependent decarboxylase domain containing 1 "GO:0001667,GO:0005783,GO:0005794,GO:0008117,GO:0016831,GO:0019752,GO:0030149,GO:0030170,GO:0043231,GO:0045296" ameboidal-type cell migration|endoplasmic reticulum|Golgi apparatus|sphinganine-1-phosphate aldolase activity|carboxy-lyase activity|carboxylic acid metabolic process|sphingolipid catabolic process|pyridoxal phosphate binding|intracellular membrane-bounded organelle|cadherin binding PDXK 3294.318437 3340.220092 3248.416781 0.97251579 -0.040206421 0.900283774 1 17.34013572 17.58996938 8566 pyridoxal kinase "GO:0000287,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0008270,GO:0008478,GO:0009443,GO:0016310,GO:0030170,GO:0030955,GO:0031402,GO:0031403,GO:0034774,GO:0035580,GO:0042803,GO:0042816,GO:0043312,GO:0070062" magnesium ion binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytosol|zinc ion binding|pyridoxal kinase activity|pyridoxal 5'-phosphate salvage|phosphorylation|pyridoxal phosphate binding|potassium ion binding|sodium ion binding|lithium ion binding|secretory granule lumen|specific granule lumen|protein homodimerization activity|vitamin B6 metabolic process|neutrophil degranulation|extracellular exosome hsa00750 Vitamin B6 metabolism PDXP 788.8358014 952.0286983 625.6429045 0.657168114 -0.605665612 0.100532503 1 23.96465955 16.427205 57026 pyridoxal phosphatase "GO:0000287,GO:0004647,GO:0004721,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006114,GO:0006470,GO:0006650,GO:0007088,GO:0015629,GO:0016311,GO:0016791,GO:0030027,GO:0030496,GO:0030836,GO:0031072,GO:0031247,GO:0031258,GO:0032154,GO:0032361,GO:0032465,GO:0032587,GO:0033883,GO:0042803,GO:0043136,GO:0070938,GO:0071318" magnesium ion binding|phosphoserine phosphatase activity|phosphoprotein phosphatase activity|protein binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|glycerol biosynthetic process|protein dephosphorylation|glycerophospholipid metabolic process|regulation of mitotic nuclear division|actin cytoskeleton|dephosphorylation|phosphatase activity|lamellipodium|midbody|positive regulation of actin filament depolymerization|heat shock protein binding|actin rod assembly|lamellipodium membrane|cleavage furrow|pyridoxal phosphate catabolic process|regulation of cytokinesis|ruffle membrane|pyridoxal phosphatase activity|protein homodimerization activity|glycerol-3-phosphatase activity|contractile ring|cellular response to ATP hsa00750 Vitamin B6 metabolism PDZD11 1525.570363 1373.235425 1677.905301 1.221862814 0.289082314 0.382447221 1 61.98710321 79.00229705 51248 PDZ domain containing 11 "GO:0005515,GO:0005576,GO:0005829,GO:0005911,GO:0005912,GO:0006768,GO:0007269,GO:0015939,GO:0016323,GO:0019730,GO:0034220,GO:0045199,GO:0045202,GO:0046930,GO:0046931,GO:0055085,GO:0098793,GO:1903361" protein binding|extracellular region|cytosol|cell-cell junction|adherens junction|biotin metabolic process|neurotransmitter secretion|pantothenate metabolic process|basolateral plasma membrane|antimicrobial humoral response|ion transmembrane transport|maintenance of epithelial cell apical/basal polarity|synapse|pore complex|pore complex assembly|transmembrane transport|presynapse|protein localization to basolateral plasma membrane PDZD2 549.0901872 559.2407386 538.9396359 0.963698813 -0.053345767 0.898132837 1 2.190192586 2.201605788 23037 PDZ domain containing 2 "GO:0005576,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0005911,GO:0007155,GO:0034451,GO:0043231" extracellular region|nucleus|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|cell-cell junction|cell adhesion|centriolar satellite|intracellular membrane-bounded organelle PDZD4 518.296096 340.0102494 696.5819425 2.04870866 1.034714838 0.011173952 0.454810043 4.070035369 8.697497575 57595 PDZ domain containing 4 GO:0005938 cell cortex PDZD7 98.56281417 103.5255088 93.60011957 0.904126149 -0.145404015 0.843936235 1 0.822979407 0.77612903 79955 PDZ domain containing 7 "GO:0001917,GO:0002141,GO:0002142,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005886,GO:0005929,GO:0007605,GO:0032391,GO:0032420,GO:0032426,GO:0042802,GO:0045184,GO:0050910,GO:0060088,GO:0060117,GO:1990696" photoreceptor inner segment|stereocilia ankle link|stereocilia ankle link complex|protein binding|extracellular space|nucleus|nucleoplasm|plasma membrane|cilium|sensory perception of sound|photoreceptor connecting cilium|stereocilium|stereocilium tip|identical protein binding|establishment of protein localization|detection of mechanical stimulus involved in sensory perception of sound|auditory receptor cell stereocilium organization|auditory receptor cell development|USH2 complex PDZD8 913.8955966 879.9668246 947.8243687 1.077113753 0.107170619 0.766895628 1 4.551855309 5.114061535 118987 PDZ domain containing 8 "GO:0005739,GO:0005789,GO:0006869,GO:0007010,GO:0008289,GO:0016020,GO:0016021,GO:0016032,GO:0022604,GO:0035556,GO:0044233,GO:0046872,GO:0051560,GO:1990456" mitochondrion|endoplasmic reticulum membrane|lipid transport|cytoskeleton organization|lipid binding|membrane|integral component of membrane|viral process|regulation of cell morphogenesis|intracellular signal transduction|mitochondria-associated endoplasmic reticulum membrane|metal ion binding|mitochondrial calcium ion homeostasis|mitochondrion-endoplasmic reticulum membrane tethering PDZK1IP1 9.030683284 11.16451565 6.896850916 0.617747436 -0.694910978 0.677685443 1 0.674753379 0.434782394 10158 PDZK1 interacting protein 1 "GO:0005515,GO:0016021,GO:0070062" protein binding|integral component of membrane|extracellular exosome PEA15 7320.304075 6081.616162 8558.991987 1.407354847 0.492986132 0.134095974 1 112.3722743 164.960025 8682 proliferation and apoptosis adaptor protein 15 "GO:0000165,GO:0000187,GO:0005515,GO:0005654,GO:0005829,GO:0005875,GO:0006915,GO:0008643,GO:0043278,GO:0046325,GO:1902042,GO:1902043" MAPK cascade|activation of MAPK activity|protein binding|nucleoplasm|cytosol|microtubule associated complex|apoptotic process|carbohydrate transport|response to morphine|negative regulation of glucose import|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors PEAK1 1778.063794 1593.48087 1962.646718 1.231672594 0.300618807 0.35571967 1 5.583519069 7.173303591 79834 pseudopodium enriched atypical kinase 1 "GO:0004672,GO:0004715,GO:0005515,GO:0005524,GO:0005737,GO:0005925,GO:0006468,GO:0015629,GO:0016477,GO:0018108,GO:0034446,GO:0042802,GO:0046777,GO:0048041,GO:0051893" protein kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|cytoplasm|focal adhesion|protein phosphorylation|actin cytoskeleton|cell migration|peptidyl-tyrosine phosphorylation|substrate adhesion-dependent cell spreading|identical protein binding|protein autophosphorylation|focal adhesion assembly|regulation of focal adhesion assembly PEAK3 5.030242514 7.104691779 2.95579325 0.416033987 -1.265226703 0.543955984 1 0.140338368 0.060900543 374872 PEAK family member 3 "GO:0004672,GO:0005515,GO:0005925,GO:0006468,GO:0008360,GO:0015629,GO:0032956,GO:0043621" protein kinase activity|protein binding|focal adhesion|protein phosphorylation|regulation of cell shape|actin cytoskeleton|regulation of actin cytoskeleton organization|protein self-association PEAR1 248.9086717 244.6043884 253.2129551 1.035193836 0.049900932 0.929060462 1 1.921270062 2.074560107 375033 platelet endothelial aggregation receptor 1 "GO:0001891,GO:0005515,GO:0014065,GO:0016020,GO:0016021,GO:0038023,GO:0043491,GO:0043654,GO:0070527" phagocytic cup|protein binding|phosphatidylinositol 3-kinase signaling|membrane|integral component of membrane|signaling receptor activity|protein kinase B signaling|recognition of apoptotic cell|platelet aggregation PEBP1 2974.197068 2605.391971 3343.002165 1.283109107 0.359643853 0.258530189 1 92.21097977 123.4133536 5037 phosphatidylethanolamine binding protein 1 "GO:0000165,GO:0003723,GO:0004867,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0008429,GO:0010951,GO:0019899,GO:0019901,GO:0043409,GO:0070062" MAPK cascade|RNA binding|serine-type endopeptidase inhibitor activity|protein binding|ATP binding|nucleus|cytosol|phosphatidylethanolamine binding|negative regulation of endopeptidase activity|enzyme binding|protein kinase binding|negative regulation of MAPK cascade|extracellular exosome PECAM1 29.92635529 58.86744617 0.985264417 0.016736999 -5.900815276 3.91E-05 0.007466295 0.407577372 0.00711547 5175 platelet and endothelial cell adhesion molecule 1 "GO:0001934,GO:0002576,GO:0004888,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0005911,GO:0006909,GO:0007156,GO:0007159,GO:0007165,GO:0007166,GO:0008037,GO:0030198,GO:0030335,GO:0030667,GO:0031092,GO:0032991,GO:0035633,GO:0035696,GO:0042803,GO:0043312,GO:0045121,GO:0050731,GO:0050900,GO:0050904,GO:0061028,GO:0070062,GO:0070830,GO:0072011,GO:0072672,GO:0098609,GO:0098742,GO:0150107" positive regulation of protein phosphorylation|platelet degranulation|transmembrane signaling receptor activity|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|cell-cell junction|phagocytosis|homophilic cell adhesion via plasma membrane adhesion molecules|leukocyte cell-cell adhesion|signal transduction|cell surface receptor signaling pathway|cell recognition|extracellular matrix organization|positive regulation of cell migration|secretory granule membrane|platelet alpha granule membrane|protein-containing complex|maintenance of blood-brain barrier|monocyte extravasation|protein homodimerization activity|neutrophil degranulation|membrane raft|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|diapedesis|establishment of endothelial barrier|extracellular exosome|bicellular tight junction assembly|glomerular endothelium development|neutrophil extravasation|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules|positive regulation of protein localization to cell-cell junction "hsa04514,hsa04670,hsa05144,hsa05418" Cell adhesion molecules|Leukocyte transendothelial migration|Malaria|Fluid shear stress and atherosclerosis PECR 189.9021704 184.7219862 195.0823545 1.056086276 0.078727699 0.89511447 1 1.891149574 2.083249124 55825 peroxisomal trans-2-enoyl-CoA reductase "GO:0001561,GO:0005102,GO:0005739,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0006633,GO:0008670,GO:0019166,GO:0033306,GO:0055114" "fatty acid alpha-oxidation|signaling receptor binding|mitochondrion|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|fatty acid biosynthetic process|2,4-dienoyl-CoA reductase (NADPH) activity|trans-2-enoyl-CoA reductase (NADPH) activity|phytol metabolic process|oxidation-reduction process" hsa04146 Peroxisome PEDS1 854.9348704 991.6119811 718.2577597 0.724333483 -0.465274029 0.199598368 1 6.519751869 4.925899629 387521 plasmanylethanolamine desaturase 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006631,GO:0008611,GO:0016021,GO:0016491,GO:0050207,GO:0055114" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|ether lipid biosynthetic process|integral component of membrane|oxidoreductase activity|plasmanylethanolamine desaturase activity|oxidation-reduction process hsa00565 Ether lipid metabolism PEF1 948.4783285 954.0586103 942.8980466 0.988302015 -0.016976113 0.965156526 1 22.68530652 23.38569398 553115 penta-EF-hand domain containing 1 "GO:0000139,GO:0003723,GO:0005509,GO:0005515,GO:0005737,GO:0005783,GO:0006888,GO:0014029,GO:0014032,GO:0016567,GO:0030127,GO:0031463,GO:0042802,GO:0046982,GO:0046983,GO:0048208,GO:0048306,GO:0051592,GO:0070062,GO:1902527,GO:1990756" Golgi membrane|RNA binding|calcium ion binding|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum to Golgi vesicle-mediated transport|neural crest formation|neural crest cell development|protein ubiquitination|COPII vesicle coat|Cul3-RING ubiquitin ligase complex|identical protein binding|protein heterodimerization activity|protein dimerization activity|COPII vesicle coating|calcium-dependent protein binding|response to calcium ion|extracellular exosome|positive regulation of protein monoubiquitination|ubiquitin ligase-substrate adaptor activity PEG10 1673.7334 2106.033634 1241.433165 0.589465023 -0.762521884 0.020313386 0.616714654 16.11713115 9.909727451 23089 paternally expressed 10 "GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0008270,GO:0030154,GO:0030512" DNA binding|RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|apoptotic process|zinc ion binding|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway PELI1 158.1240524 133.9741878 182.2739171 1.360515186 0.44415306 0.447968753 1 1.301864923 1.847503412 57162 pellino E3 ubiquitin protein ligase 1 "GO:0000209,GO:0000778,GO:0001819,GO:0005515,GO:0005829,GO:0008063,GO:0008592,GO:0030890,GO:0031398,GO:0032088,GO:0032496,GO:0034141,GO:0034145,GO:0034450,GO:0042130,GO:0043123,GO:0043161,GO:0043331,GO:0060546,GO:0061630,GO:0070498,GO:0070534,GO:0070936" protein polyubiquitination|condensed nuclear chromosome kinetochore|positive regulation of cytokine production|protein binding|cytosol|Toll signaling pathway|regulation of Toll signaling pathway|positive regulation of B cell proliferation|positive regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|response to lipopolysaccharide|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|ubiquitin-ubiquitin ligase activity|negative regulation of T cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|response to dsRNA|negative regulation of necroptotic process|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination|protein K48-linked ubiquitination PELI2 323.7387868 308.5466144 338.9309593 1.098475703 0.13550296 0.774195989 1 0.688314211 0.788666005 57161 pellino E3 ubiquitin protein ligase family member 2 "GO:0000209,GO:0001934,GO:0005515,GO:0005829,GO:0008063,GO:0008592,GO:0034450,GO:0043123,GO:0043410,GO:0061630,GO:0070498" protein polyubiquitination|positive regulation of protein phosphorylation|protein binding|cytosol|Toll signaling pathway|regulation of Toll signaling pathway|ubiquitin-ubiquitin ligase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway PELI3 386.2679425 373.5037964 399.0320887 1.068348147 0.09538186 0.832667134 1 6.328755317 7.052564002 246330 pellino E3 ubiquitin protein ligase family member 3 "GO:0000209,GO:0005515,GO:0005829,GO:0008063,GO:0008592,GO:0010804,GO:0061630,GO:0070498,GO:0070534,GO:2001237" protein polyubiquitination|protein binding|cytosol|Toll signaling pathway|regulation of Toll signaling pathway|negative regulation of tumor necrosis factor-mediated signaling pathway|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination|negative regulation of extrinsic apoptotic signaling pathway PELO 913.55266 1058.599075 768.5062449 0.725965347 -0.46202741 0.197144471 1 12.26591367 9.288203544 53918 pelota mRNA surveillance and ribosome rescue factor "GO:0001833,GO:0004519,GO:0005515,GO:0005634,GO:0005737,GO:0007049,GO:0007492,GO:0019827,GO:0030513,GO:0032790,GO:0046872,GO:0051276,GO:0051301,GO:0060231,GO:0070481,GO:0070651,GO:0070966,GO:0071025,GO:0090305" "inner cell mass cell proliferation|endonuclease activity|protein binding|nucleus|cytoplasm|cell cycle|endoderm development|stem cell population maintenance|positive regulation of BMP signaling pathway|ribosome disassembly|metal ion binding|chromosome organization|cell division|mesenchymal to epithelial transition|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, no-go decay|RNA surveillance|nucleic acid phosphodiester bond hydrolysis" hsa03015 mRNA surveillance pathway PELP1 1162.93788 1133.705817 1192.169944 1.051569046 0.07254358 0.834929612 1 11.63489365 12.76192362 27043 "proline, glutamate and leucine rich protein 1" "GO:0003682,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008134,GO:0035327,GO:0045944,GO:0071339,GO:0071391" chromatin binding|RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|rRNA processing|transcription factor binding|transcriptionally active chromatin|positive regulation of transcription by RNA polymerase II|MLL1 complex|cellular response to estrogen stimulus PEMT 292.6529772 372.4888404 212.817114 0.571338228 -0.807583032 0.090813762 1 11.93247673 7.111149501 10400 phosphatidylethanolamine N-methyltransferase "GO:0000773,GO:0001835,GO:0004608,GO:0005739,GO:0005783,GO:0005789,GO:0005829,GO:0006656,GO:0006686,GO:0008285,GO:0008429,GO:0016021,GO:0031526,GO:0031966,GO:0032259,GO:0033273,GO:0042383,GO:0042493,GO:0043200,GO:0043231,GO:0045471,GO:0046498,GO:0046500,GO:0050747,GO:0080101,GO:0120162" phosphatidyl-N-methylethanolamine N-methyltransferase activity|blastocyst hatching|phosphatidylethanolamine N-methyltransferase activity|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|phosphatidylcholine biosynthetic process|sphingomyelin biosynthetic process|negative regulation of cell population proliferation|phosphatidylethanolamine binding|integral component of membrane|brush border membrane|mitochondrial membrane|methylation|response to vitamin|sarcolemma|response to drug|response to amino acid|intracellular membrane-bounded organelle|response to ethanol|S-adenosylhomocysteine metabolic process|S-adenosylmethionine metabolic process|positive regulation of lipoprotein metabolic process|phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|positive regulation of cold-induced thermogenesis hsa00564 Glycerophospholipid metabolism PEPD 707.832319 802.830171 612.8344671 0.763342596 -0.389597396 0.301353395 1 21.32171785 16.97686986 5184 peptidase D "GO:0004181,GO:0005515,GO:0006508,GO:0006520,GO:0008233,GO:0030145,GO:0030574,GO:0070006,GO:0070062,GO:0102009" metallocarboxypeptidase activity|protein binding|proteolysis|cellular amino acid metabolic process|peptidase activity|manganese ion binding|collagen catabolic process|metalloaminopeptidase activity|extracellular exosome|proline dipeptidase activity PER1 405.2876036 360.3093688 450.2658384 1.249664531 0.321540859 0.458042533 1 3.361900964 4.382221134 5187 period circadian regulator 1 "GO:0000122,GO:0000976,GO:0000978,GO:0001222,GO:0002028,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007623,GO:0009649,GO:0010608,GO:0019900,GO:0031490,GO:0031625,GO:0032922,GO:0042634,GO:0042752,GO:0043124,GO:0043153,GO:0043966,GO:0043967,GO:0045892,GO:0045944,GO:0046329,GO:0051591,GO:0070888,GO:0070932,GO:0097167,GO:1900015,GO:1900744,GO:2000323" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription corepressor binding|regulation of sodium ion transport|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|circadian rhythm|entrainment of circadian clock|posttranscriptional regulation of gene expression|kinase binding|chromatin DNA binding|ubiquitin protein ligase binding|circadian regulation of gene expression|regulation of hair cycle|regulation of circadian rhythm|negative regulation of I-kappaB kinase/NF-kappaB signaling|entrainment of circadian clock by photoperiod|histone H3 acetylation|histone H4 acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|response to cAMP|E-box binding|histone H3 deacetylation|circadian regulation of translation|regulation of cytokine production involved in inflammatory response|regulation of p38MAPK cascade|negative regulation of glucocorticoid receptor signaling pathway" "hsa04710,hsa04713" Circadian rhythm|Circadian entrainment PER2 80.011537 47.70293051 112.3201435 2.354575333 1.235466881 0.092776493 1 0.357341391 0.877630774 8864 period circadian regulator 2 "GO:0000122,GO:0000976,GO:0001222,GO:0002931,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005978,GO:0006094,GO:0006631,GO:0007623,GO:0019229,GO:0019249,GO:0031397,GO:0032922,GO:0042752,GO:0042754,GO:0043153,GO:0045892,GO:0045893,GO:0048471,GO:0050767,GO:0050796,GO:0050872,GO:0051726,GO:0051946,GO:0070345,GO:0070932,GO:0097167,GO:0120162,GO:2000678" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|transcription corepressor binding|response to ischemia|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|glycogen biosynthetic process|gluconeogenesis|fatty acid metabolic process|circadian rhythm|regulation of vasoconstriction|lactate biosynthetic process|negative regulation of protein ubiquitination|circadian regulation of gene expression|regulation of circadian rhythm|negative regulation of circadian rhythm|entrainment of circadian clock by photoperiod|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm|regulation of neurogenesis|regulation of insulin secretion|white fat cell differentiation|regulation of cell cycle|regulation of glutamate uptake involved in transmission of nerve impulse|negative regulation of fat cell proliferation|histone H3 deacetylation|circadian regulation of translation|positive regulation of cold-induced thermogenesis|negative regulation of transcription regulatory region DNA binding" "hsa04710,hsa04713,hsa05202,hsa05221" Circadian rhythm|Circadian entrainment|Transcriptional misregulation in cancer|Acute myeloid leukemia PER3 97.83264955 87.28621328 108.3790858 1.241651823 0.312260678 0.655477353 1 0.78354108 1.01479316 8863 period circadian regulator 3 "GO:0000122,GO:0000976,GO:0001222,GO:0005515,GO:0005634,GO:0005737,GO:0032922,GO:0043153,GO:0045187,GO:0050821" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|transcription corepressor binding|protein binding|nucleus|cytoplasm|circadian regulation of gene expression|entrainment of circadian clock by photoperiod|regulation of circadian sleep/wake cycle, sleep|protein stabilization" "hsa04710,hsa04713" Circadian rhythm|Circadian entrainment PERP 2900.913635 2613.511619 3188.315652 1.219935519 0.286804894 0.367610081 1 27.39911893 34.86497863 64065 p53 apoptosis effector related to PMP22 "GO:0002934,GO:0005515,GO:0005739,GO:0005794,GO:0005886,GO:0005887,GO:0005911,GO:0007219,GO:0030057,GO:0034113,GO:0042981,GO:0045862,GO:0070268,GO:0072332,GO:0097186,GO:0097202,GO:0098609" desmosome organization|protein binding|mitochondrion|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell-cell junction|Notch signaling pathway|desmosome|heterotypic cell-cell adhesion|regulation of apoptotic process|positive regulation of proteolysis|cornification|intrinsic apoptotic signaling pathway by p53 class mediator|amelogenesis|activation of cysteine-type endopeptidase activity|cell-cell adhesion hsa04115 p53 signaling pathway PES1 2015.432354 2396.311041 1634.553667 0.68211248 -0.551918437 0.087051029 1 23.63940408 16.81932063 23481 pescadillo ribosomal biogenesis factor 1 "GO:0000463,GO:0000466,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006364,GO:0008283,GO:0016020,GO:0030687,GO:0042273,GO:0043021,GO:0051726,GO:0070545" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|cytosol|rRNA processing|cell population proliferation|membrane|preribosome, large subunit precursor|ribosomal large subunit biogenesis|ribonucleoprotein complex binding|regulation of cell cycle|PeBoW complex" PET100 376.7891644 365.3841486 388.1941801 1.062427534 0.087364442 0.848342006 1 27.91164122 30.93147436 100131801 PET100 cytochrome c oxidase chaperone "GO:0031305,GO:0033617,GO:0051082" integral component of mitochondrial inner membrane|mitochondrial cytochrome c oxidase assembly|unfolded protein binding PET117 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.223301213 0.135663763 100303755 PET117 cytochrome c oxidase chaperone "GO:0005739,GO:0033617" mitochondrion|mitochondrial cytochrome c oxidase assembly PEX1 471.2651847 425.2665507 517.2638187 1.216328483 0.282532898 0.497220772 1 4.888390954 6.202013946 5189 peroxisomal biogenesis factor 1 "GO:0005515,GO:0005524,GO:0005737,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0007031,GO:0008022,GO:0016558,GO:0016887,GO:0044877,GO:0060152,GO:0070062" protein binding|ATP binding|cytoplasm|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|peroxisome organization|protein C-terminus binding|protein import into peroxisome matrix|ATPase activity|protein-containing complex binding|microtubule-based peroxisome localization|extracellular exosome hsa04146 Peroxisome PEX10 824.215008 777.4562718 870.9737442 1.120286472 0.163867696 0.655330837 1 12.55593669 14.67216286 5192 peroxisomal biogenesis factor 10 "GO:0005515,GO:0005777,GO:0005778,GO:0006625,GO:0007031,GO:0016558,GO:0016567,GO:0046872" protein binding|peroxisome|peroxisomal membrane|protein targeting to peroxisome|peroxisome organization|protein import into peroxisome matrix|protein ubiquitination|metal ion binding hsa04146 Peroxisome PEX11A 363.1884576 378.5785762 347.798339 0.918695248 -0.122341728 0.788597175 1 7.080380111 6.784908157 8800 peroxisomal biogenesis factor 11 alpha "GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0007031,GO:0007165,GO:0016557,GO:0016559,GO:0019216,GO:0032991,GO:0042803,GO:0044375,GO:0050873" protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|peroxisome organization|signal transduction|peroxisome membrane biogenesis|peroxisome fission|regulation of lipid metabolic process|protein-containing complex|protein homodimerization activity|regulation of peroxisome size|brown fat cell differentiation hsa04146 Peroxisome PEX11B 599.4601603 533.8668394 665.0534812 1.245729145 0.316990421 0.41829384 1 15.72004189 20.42646686 8799 peroxisomal biogenesis factor 11 beta "GO:0005515,GO:0005654,GO:0005739,GO:0005777,GO:0005778,GO:0005779,GO:0007031,GO:0007165,GO:0016020,GO:0016559,GO:0032991,GO:0042802,GO:0042803,GO:0043231,GO:0044375" protein binding|nucleoplasm|mitochondrion|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|peroxisome organization|signal transduction|membrane|peroxisome fission|protein-containing complex|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|regulation of peroxisome size hsa04146 Peroxisome PEX11G 44.61624688 52.77771036 36.45478341 0.690723094 -0.533820634 0.552575033 1 1.404626821 1.012000818 92960 peroxisomal biogenesis factor 11 gamma "GO:0005515,GO:0005777,GO:0005779,GO:0016559,GO:0031231,GO:0032991,GO:0044375" protein binding|peroxisome|integral component of peroxisomal membrane|peroxisome fission|intrinsic component of peroxisomal membrane|protein-containing complex|regulation of peroxisome size hsa04146 Peroxisome PEX12 155.4948663 156.3032191 154.6865134 0.989656606 -0.015000073 0.992053397 1 3.024916563 3.122582041 5193 peroxisomal biogenesis factor 12 "GO:0004842,GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0006513,GO:0006625,GO:0007031,GO:0008022,GO:0008270,GO:0016558,GO:0016567,GO:1990429" ubiquitin-protein transferase activity|protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|protein monoubiquitination|protein targeting to peroxisome|peroxisome organization|protein C-terminus binding|zinc ion binding|protein import into peroxisome matrix|protein ubiquitination|peroxisomal importomer complex hsa04146 Peroxisome PEX13 423.824035 415.1169911 432.5310789 1.041949831 0.059285815 0.894847451 1 4.701299453 5.109526469 5194 peroxisomal biogenesis factor 13 "GO:0001561,GO:0001764,GO:0001967,GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0006625,GO:0007626,GO:0016020,GO:0016560,GO:0016567,GO:0021795,GO:0060152,GO:1990429" "fatty acid alpha-oxidation|neuron migration|suckling behavior|protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|protein targeting to peroxisome|locomotory behavior|membrane|protein import into peroxisome matrix, docking|protein ubiquitination|cerebral cortex cell migration|microtubule-based peroxisome localization|peroxisomal importomer complex" hsa04146 Peroxisome PEX14 667.1652946 649.5718198 684.7587695 1.054169452 0.076106791 0.845361417 1 5.470322767 6.015050927 5195 peroxisomal biogenesis factor 14 "GO:0001650,GO:0003714,GO:0005102,GO:0005515,GO:0005634,GO:0005777,GO:0005778,GO:0006625,GO:0007031,GO:0008017,GO:0016020,GO:0016021,GO:0016558,GO:0016560,GO:0016561,GO:0016567,GO:0032091,GO:0032991,GO:0034453,GO:0036250,GO:0042802,GO:0043433,GO:0044721,GO:0045892,GO:0047485,GO:0048487,GO:0065003,GO:1990429" "fibrillar center|transcription corepressor activity|signaling receptor binding|protein binding|nucleus|peroxisome|peroxisomal membrane|protein targeting to peroxisome|peroxisome organization|microtubule binding|membrane|integral component of membrane|protein import into peroxisome matrix|protein import into peroxisome matrix, docking|protein import into peroxisome matrix, translocation|protein ubiquitination|negative regulation of protein binding|protein-containing complex|microtubule anchoring|peroxisome transport along microtubule|identical protein binding|negative regulation of DNA-binding transcription factor activity|protein import into peroxisome matrix, substrate release|negative regulation of transcription, DNA-templated|protein N-terminus binding|beta-tubulin binding|protein-containing complex assembly|peroxisomal importomer complex" hsa04146 Peroxisome PEX16 561.9782967 497.3284245 626.6281689 1.259988647 0.333410735 0.40174262 1 15.1006776 19.84627465 9409 peroxisomal biogenesis factor 16 "GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0005783,GO:0005789,GO:0006625,GO:0007031,GO:0008022,GO:0016020,GO:0016557,GO:0016558,GO:0022615,GO:0032581,GO:0045046,GO:0106101" protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|protein targeting to peroxisome|peroxisome organization|protein C-terminus binding|membrane|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein to membrane docking|ER-dependent peroxisome organization|protein import into peroxisome membrane|ER-dependent peroxisome localization hsa04146 Peroxisome PEX19 2089.330399 1621.899637 2556.761161 1.57639912 0.656632849 0.04154361 0.936262454 22.37632659 36.79348333 5824 peroxisomal biogenesis factor 19 "GO:0005515,GO:0005654,GO:0005737,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0007031,GO:0016559,GO:0031526,GO:0032991,GO:0033328,GO:0036105,GO:0045046,GO:0047485,GO:0050821,GO:0051117,GO:0055085,GO:0061077,GO:0072321,GO:0072663,GO:1900131" protein binding|nucleoplasm|cytoplasm|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|peroxisome organization|peroxisome fission|brush border membrane|protein-containing complex|peroxisome membrane targeting sequence binding|peroxisome membrane class-1 targeting sequence binding|protein import into peroxisome membrane|protein N-terminus binding|protein stabilization|ATPase binding|transmembrane transport|chaperone-mediated protein folding|chaperone-mediated protein transport|establishment of protein localization to peroxisome|negative regulation of lipid binding hsa04146 Peroxisome PEX2 989.3383479 1120.511389 858.1653068 0.76586933 -0.384829829 0.275816754 1 13.10319763 10.46761882 5828 peroxisomal biogenesis factor 2 "GO:0000038,GO:0000122,GO:0005515,GO:0005778,GO:0005779,GO:0006625,GO:0006635,GO:0007031,GO:0016020,GO:0016558,GO:0016567,GO:0016593,GO:0031648,GO:0046872,GO:0048147,GO:0050680" very long-chain fatty acid metabolic process|negative regulation of transcription by RNA polymerase II|protein binding|peroxisomal membrane|integral component of peroxisomal membrane|protein targeting to peroxisome|fatty acid beta-oxidation|peroxisome organization|membrane|protein import into peroxisome matrix|protein ubiquitination|Cdc73/Paf1 complex|protein destabilization|metal ion binding|negative regulation of fibroblast proliferation|negative regulation of epithelial cell proliferation hsa04146 Peroxisome PEX26 1574.767274 1638.138933 1511.395615 0.922629689 -0.116176377 0.725627499 1 4.514417126 4.344552407 55670 peroxisomal biogenesis factor 26 "GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0006625,GO:0008022,GO:0016558,GO:0044877,GO:0045046,GO:0051117" protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|protein targeting to peroxisome|protein C-terminus binding|protein import into peroxisome matrix|protein-containing complex binding|protein import into peroxisome membrane|ATPase binding hsa04146 Peroxisome PEX3 455.3591773 516.6125879 394.1057666 0.762865203 -0.390499938 0.351334804 1 9.514401846 7.570860176 8504 peroxisomal biogenesis factor 3 "GO:0005515,GO:0005654,GO:0005777,GO:0005778,GO:0005779,GO:0005783,GO:0005829,GO:0007031,GO:0008289,GO:0016020,GO:0016557,GO:0030674,GO:0032991,GO:0032994,GO:0045046,GO:0055085" protein binding|nucleoplasm|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum|cytosol|peroxisome organization|lipid binding|membrane|peroxisome membrane biogenesis|protein-macromolecule adaptor activity|protein-containing complex|protein-lipid complex|protein import into peroxisome membrane|transmembrane transport hsa04146 Peroxisome PEX5 829.7324395 851.5480575 807.9168216 0.94876245 -0.075881182 0.837991274 1 8.667183487 8.577315965 5830 peroxisomal biogenesis factor 5 "GO:0000268,GO:0005052,GO:0005515,GO:0005737,GO:0005777,GO:0005778,GO:0005794,GO:0005829,GO:0006625,GO:0016020,GO:0016558,GO:0016560,GO:0016567,GO:0019899,GO:0031267,GO:0031333,GO:0032991,GO:0033328,GO:0045046,GO:0047485,GO:0140311" "peroxisome targeting sequence binding|peroxisome matrix targeting signal-1 binding|protein binding|cytoplasm|peroxisome|peroxisomal membrane|Golgi apparatus|cytosol|protein targeting to peroxisome|membrane|protein import into peroxisome matrix|protein import into peroxisome matrix, docking|protein ubiquitination|enzyme binding|small GTPase binding|negative regulation of protein-containing complex assembly|protein-containing complex|peroxisome membrane targeting sequence binding|protein import into peroxisome membrane|protein N-terminus binding|protein sequestering activity" hsa04146 Peroxisome PEX6 166.9144817 162.3929549 171.4360085 1.055686243 0.07818112 0.901534032 1 1.837495594 2.023378348 5190 peroxisomal biogenesis factor 6 "GO:0001750,GO:0005515,GO:0005524,GO:0005737,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0007031,GO:0008022,GO:0016558,GO:0016561,GO:0016887,GO:0044877,GO:0050821,GO:0097733" "photoreceptor outer segment|protein binding|ATP binding|cytoplasm|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|peroxisome organization|protein C-terminus binding|protein import into peroxisome matrix|protein import into peroxisome matrix, translocation|ATPase activity|protein-containing complex binding|protein stabilization|photoreceptor cell cilium" hsa04146 Peroxisome PEX7 115.460767 113.6750685 117.2464656 1.031417594 0.04462856 0.959449082 1 2.002518677 2.154403472 5191 peroxisomal biogenesis factor 7 "GO:0001764,GO:0001958,GO:0005053,GO:0005515,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0007031,GO:0008611,GO:0016558,GO:0019899,GO:0042803" neuron migration|endochondral ossification|peroxisome matrix targeting signal-2 binding|protein binding|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|peroxisome organization|ether lipid biosynthetic process|protein import into peroxisome matrix|enzyme binding|protein homodimerization activity hsa04146 Peroxisome PF4 4.985705186 4.059823873 5.911586499 1.456118956 0.542128219 0.871693704 1 0.191270472 0.290509751 5196 platelet factor 4 "GO:0002576,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0006954,GO:0007186,GO:0007189,GO:0008009,GO:0008201,GO:0010628,GO:0010744,GO:0016525,GO:0019221,GO:0020005,GO:0030168,GO:0030593,GO:0030595,GO:0031093,GO:0032760,GO:0042127,GO:0042832,GO:0045236,GO:0045347,GO:0045651,GO:0045652,GO:0045653,GO:0045944,GO:0048248,GO:0051873,GO:0061844,GO:0062023,GO:0070098,GO:0071222,GO:2001240" platelet degranulation|protein binding|extracellular region|extracellular space|cytoplasm|inflammatory response|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|chemokine activity|heparin binding|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|negative regulation of angiogenesis|cytokine-mediated signaling pathway|symbiont-containing vacuole membrane|platelet activation|neutrophil chemotaxis|leukocyte chemotaxis|platelet alpha granule lumen|positive regulation of tumor necrosis factor production|regulation of cell population proliferation|defense response to protozoan|CXCR chemokine receptor binding|negative regulation of MHC class II biosynthetic process|positive regulation of macrophage differentiation|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|CXCR3 chemokine receptor binding|killing by host of symbiont cells|antimicrobial humoral immune response mediated by antimicrobial peptide|collagen-containing extracellular matrix|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04060,hsa04061,hsa04062" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway PFAS 1416.848341 1551.867676 1281.829006 0.825991176 -0.275801726 0.409146037 1 13.35768578 11.50860171 5198 phosphoribosylformylglycinamidine synthase "GO:0004642,GO:0005524,GO:0005829,GO:0006189,GO:0006541,GO:0009168,GO:0042493,GO:0046872,GO:0070062,GO:0097065" phosphoribosylformylglycinamidine synthase activity|ATP binding|cytosol|'de novo' IMP biosynthetic process|glutamine metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to drug|metal ion binding|extracellular exosome|anterior head development hsa00230 Purine metabolism PFDN1 1370.636915 1288.99408 1452.27975 1.126676819 0.172073746 0.608857543 1 33.51283514 39.3846018 5201 prefoldin subunit 1 "GO:0001540,GO:0005515,GO:0005737,GO:0006457,GO:0016272,GO:0044183,GO:0051082,GO:1905907" amyloid-beta binding|protein binding|cytoplasm|protein folding|prefoldin complex|protein folding chaperone|unfolded protein binding|negative regulation of amyloid fibril formation PFDN2 805.7716106 863.7275291 747.8156922 0.86580046 -0.207893528 0.572125893 1 67.09317837 60.59155637 5202 prefoldin subunit 2 "GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006457,GO:0016272,GO:0044183,GO:0051082,GO:0051495,GO:1905907" amyloid-beta binding|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|protein folding|prefoldin complex|protein folding chaperone|unfolded protein binding|positive regulation of cytoskeleton organization|negative regulation of amyloid fibril formation PFDN4 543.8817954 539.9565752 547.8070156 1.014539022 0.020824356 0.96350124 1 19.99042082 21.15468788 5203 prefoldin subunit 4 "GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006457,GO:0016272,GO:0051082,GO:0051087,GO:1905907" amyloid-beta binding|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|protein folding|prefoldin complex|unfolded protein binding|chaperone binding|negative regulation of amyloid fibril formation PFDN5 3324.109942 3221.470244 3426.749641 1.06372227 0.089121523 0.779932557 1 273.751851 303.7394805 5204 prefoldin subunit 5 "GO:0001540,GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006457,GO:0016272,GO:0045111,GO:0045892,GO:0051082,GO:0090090,GO:1905907" "amyloid-beta binding|transcription corepressor activity|protein binding|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|protein folding|prefoldin complex|intermediate filament cytoskeleton|negative regulation of transcription, DNA-templated|unfolded protein binding|negative regulation of canonical Wnt signaling pathway|negative regulation of amyloid fibril formation" PFDN6 511.6231694 523.7172797 499.5290592 0.953814355 -0.0682196 0.871072377 1 44.42953543 44.20298074 10471 prefoldin subunit 6 "GO:0001540,GO:0005515,GO:0005737,GO:0006457,GO:0016272,GO:0051082,GO:0051087,GO:0051131,GO:1905907" amyloid-beta binding|protein binding|cytoplasm|protein folding|prefoldin complex|unfolded protein binding|chaperone binding|chaperone-mediated protein complex assembly|negative regulation of amyloid fibril formation PFKFB1 5.56741205 10.14955968 0.985264417 0.097074597 -3.364762376 0.106651607 1 0.120808318 0.012232588 5207 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1" "GO:0003873,GO:0004331,GO:0005515,GO:0005524,GO:0005829,GO:0006000,GO:0006003,GO:0006094,GO:0006096,GO:0016311,GO:0019900,GO:0031100,GO:0032868,GO:0033133,GO:0033762,GO:0042594,GO:0042802,GO:0043540,GO:0045820,GO:0045821,GO:0046835,GO:0051384,GO:0051591,GO:0070095" "6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|protein binding|ATP binding|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolytic process|dephosphorylation|kinase binding|animal organ regeneration|response to insulin|positive regulation of glucokinase activity|response to glucagon|response to starvation|identical protein binding|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex|negative regulation of glycolytic process|positive regulation of glycolytic process|carbohydrate phosphorylation|response to glucocorticoid|response to cAMP|fructose-6-phosphate binding" "hsa00051,hsa04152,hsa04922" Fructose and mannose metabolism|AMPK signaling pathway|Glucagon signaling pathway PFKFB2 295.1930887 344.0700733 246.3161041 0.715889359 -0.48219146 0.310873736 1 1.489778183 1.112457547 5208 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2" "GO:0003873,GO:0004331,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006000,GO:0006003,GO:0006007,GO:0006089,GO:0006096,GO:0009749,GO:0016311,GO:0019901,GO:0032024,GO:0033133,GO:0045821,GO:0046835" "6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|protein binding|ATP binding|nucleoplasm|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|glucose catabolic process|lactate metabolic process|glycolytic process|response to glucose|dephosphorylation|protein kinase binding|positive regulation of insulin secretion|positive regulation of glucokinase activity|positive regulation of glycolytic process|carbohydrate phosphorylation" "hsa00051,hsa04152,hsa04919" Fructose and mannose metabolism|AMPK signaling pathway|Thyroid hormone signaling pathway PFKFB3 2770.810489 4125.796011 1415.824967 0.343164074 -1.543029572 2.12E-06 0.000796583 40.7403028 14.58283618 5209 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3" "GO:0003873,GO:0004331,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006000,GO:0006003,GO:0016311,GO:0045821,GO:0046835" "6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|protein binding|ATP binding|nucleoplasm|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|dephosphorylation|positive regulation of glycolytic process|carbohydrate phosphorylation" "hsa00051,hsa04066,hsa04152" Fructose and mannose metabolism|HIF-1 signaling pathway|AMPK signaling pathway PFKFB4 921.9932255 1534.613424 309.3730268 0.201596716 -2.310455957 7.72E-10 7.47E-07 13.63557125 2.867297264 5210 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4" "GO:0003873,GO:0004331,GO:0005515,GO:0005524,GO:0005829,GO:0006000,GO:0006003,GO:0016311,GO:0045821,GO:0046835" "6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|protein binding|ATP binding|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|dephosphorylation|positive regulation of glycolytic process|carbohydrate phosphorylation" "hsa00051,hsa04152" Fructose and mannose metabolism|AMPK signaling pathway PFKL 3479.682505 4258.755243 2700.609766 0.634131245 -0.657146631 0.039444527 0.912001904 53.45500101 35.3576526 5211 "phosphofructokinase, liver type" "GO:0003872,GO:0005515,GO:0005524,GO:0005576,GO:0005829,GO:0005945,GO:0006002,GO:0006096,GO:0009749,GO:0016020,GO:0016208,GO:0019900,GO:0030388,GO:0034774,GO:0042802,GO:0043312,GO:0046676,GO:0046872,GO:0048029,GO:0061621,GO:0070061,GO:0070062,GO:0070095,GO:1904813" "6-phosphofructokinase activity|protein binding|ATP binding|extracellular region|cytosol|6-phosphofructokinase complex|fructose 6-phosphate metabolic process|glycolytic process|response to glucose|membrane|AMP binding|kinase binding|fructose 1,6-bisphosphate metabolic process|secretory granule lumen|identical protein binding|neutrophil degranulation|negative regulation of insulin secretion|metal ion binding|monosaccharide binding|canonical glycolysis|fructose binding|extracellular exosome|fructose-6-phosphate binding|ficolin-1-rich granule lumen" "hsa00010,hsa00030,hsa00051,hsa00052,hsa03018,hsa04066,hsa04152,hsa04919,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|Galactose metabolism|RNA degradation|HIF-1 signaling pathway|AMPK signaling pathway|Thyroid hormone signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PFKM 1897.172663 1821.845963 1972.499362 1.08269272 0.114623849 0.724086046 1 18.56914288 20.97070371 5213 "phosphofructokinase, muscle" "GO:0003872,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005945,GO:0006002,GO:0006096,GO:0008022,GO:0016020,GO:0016208,GO:0016324,GO:0019900,GO:0030388,GO:0042802,GO:0045944,GO:0046716,GO:0046872,GO:0048029,GO:0061615,GO:0061621,GO:0070061,GO:0070095" "6-phosphofructokinase activity|protein binding|ATP binding|nucleus|cytosol|6-phosphofructokinase complex|fructose 6-phosphate metabolic process|glycolytic process|protein C-terminus binding|membrane|AMP binding|apical plasma membrane|kinase binding|fructose 1,6-bisphosphate metabolic process|identical protein binding|positive regulation of transcription by RNA polymerase II|muscle cell cellular homeostasis|metal ion binding|monosaccharide binding|glycolytic process through fructose-6-phosphate|canonical glycolysis|fructose binding|fructose-6-phosphate binding" "hsa00010,hsa00030,hsa00051,hsa00052,hsa03018,hsa04066,hsa04152,hsa04919,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|Galactose metabolism|RNA degradation|HIF-1 signaling pathway|AMPK signaling pathway|Thyroid hormone signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PFKP 8147.675551 9533.481411 6761.869691 0.709276014 -0.495580936 0.135031449 1 133.417298 98.70595248 5214 "phosphofructokinase, platelet" "GO:0003872,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005945,GO:0006002,GO:0016020,GO:0016208,GO:0030388,GO:0042802,GO:0044877,GO:0045296,GO:0046872,GO:0048029,GO:0061621,GO:0070062,GO:0070095,GO:1990830" "6-phosphofructokinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|6-phosphofructokinase complex|fructose 6-phosphate metabolic process|membrane|AMP binding|fructose 1,6-bisphosphate metabolic process|identical protein binding|protein-containing complex binding|cadherin binding|metal ion binding|monosaccharide binding|canonical glycolysis|extracellular exosome|fructose-6-phosphate binding|cellular response to leukemia inhibitory factor" "hsa00010,hsa00030,hsa00051,hsa00052,hsa03018,hsa04066,hsa04152,hsa04919,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|Galactose metabolism|RNA degradation|HIF-1 signaling pathway|AMPK signaling pathway|Thyroid hormone signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PFN1 30633.92547 29643.81897 31624.03198 1.066800199 0.093289999 0.811238867 1 1044.784171 1162.587374 5216 profilin 1 "GO:0000774,GO:0001784,GO:0003723,GO:0003779,GO:0003785,GO:0005515,GO:0005546,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0005938,GO:0010634,GO:0016020,GO:0030036,GO:0030833,GO:0030837,GO:0030838,GO:0032232,GO:0032233,GO:0032781,GO:0045296,GO:0050821,GO:0051497,GO:0060071,GO:0070062,GO:0070064,GO:0072562,GO:1900029" "adenyl-nucleotide exchange factor activity|phosphotyrosine residue binding|RNA binding|actin binding|actin monomer binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytoplasm|cytosol|cytoskeleton|focal adhesion|cell cortex|positive regulation of epithelial cell migration|membrane|actin cytoskeleton organization|regulation of actin filament polymerization|negative regulation of actin filament polymerization|positive regulation of actin filament polymerization|negative regulation of actin filament bundle assembly|positive regulation of actin filament bundle assembly|positive regulation of ATPase activity|cadherin binding|protein stabilization|negative regulation of stress fiber assembly|Wnt signaling pathway, planar cell polarity pathway|extracellular exosome|proline-rich region binding|blood microparticle|positive regulation of ruffle assembly" "hsa04015,hsa04810,hsa05014,hsa05131,hsa05132" Rap1 signaling pathway|Regulation of actin cytoskeleton|Amyotrophic lateral sclerosis|Shigellosis|Salmonella infection PFN2 2568.461124 2618.586398 2518.335849 0.961715775 -0.056317511 0.860841329 1 64.78855069 64.99215458 5217 profilin 2 "GO:0003779,GO:0003785,GO:0005515,GO:0005546,GO:0005737,GO:0005856,GO:0010633,GO:0016887,GO:0030036,GO:0030833,GO:0030837,GO:0030838,GO:0032233,GO:0032781,GO:0033138,GO:0050821,GO:0051496,GO:0070062,GO:1900028" "actin binding|actin monomer binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytoskeleton|negative regulation of epithelial cell migration|ATPase activity|actin cytoskeleton organization|regulation of actin filament polymerization|negative regulation of actin filament polymerization|positive regulation of actin filament polymerization|positive regulation of actin filament bundle assembly|positive regulation of ATPase activity|positive regulation of peptidyl-serine phosphorylation|protein stabilization|positive regulation of stress fiber assembly|extracellular exosome|negative regulation of ruffle assembly" "hsa04015,hsa04810,hsa05014,hsa05131,hsa05132" Rap1 signaling pathway|Regulation of actin cytoskeleton|Amyotrophic lateral sclerosis|Shigellosis|Salmonella infection PFN4 14.00154269 14.20938356 13.79370183 0.970745971 -0.042834281 1 1 0.293258007 0.296941847 375189 profilin family member 4 "GO:0003785,GO:0005856,GO:0005938,GO:0008289,GO:0042989" actin monomer binding|cytoskeleton|cell cortex|lipid binding|sequestering of actin monomers "hsa04015,hsa04810,hsa05014,hsa05131,hsa05132" Rap1 signaling pathway|Regulation of actin cytoskeleton|Amyotrophic lateral sclerosis|Shigellosis|Salmonella infection PGAM1 14820.43155 19539.9323 10100.9308 0.51693786 -0.951937226 0.006974068 0.341973728 517.3176364 278.9404874 5223 phosphoglycerate mutase 1 "GO:0004082,GO:0004619,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006094,GO:0006096,GO:0006110,GO:0016020,GO:0016787,GO:0019901,GO:0034774,GO:0043312,GO:0043456,GO:0045730,GO:0061621,GO:0070062,GO:1904813" bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein binding|extracellular region|cytoplasm|cytosol|gluconeogenesis|glycolytic process|regulation of glycolytic process|membrane|hydrolase activity|protein kinase binding|secretory granule lumen|neutrophil degranulation|regulation of pentose-phosphate shunt|respiratory burst|canonical glycolysis|extracellular exosome|ficolin-1-rich granule lumen "hsa00010,hsa00260,hsa04922,hsa05230" "Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism|Glucagon signaling pathway|Central carbon metabolism in cancer" PGAM2 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.061414503 0.186557934 5224 phosphoglycerate mutase 2 "GO:0004082,GO:0004619,GO:0005515,GO:0005634,GO:0005829,GO:0006094,GO:0006096,GO:0006941,GO:0007219,GO:0007283,GO:0016787,GO:0042802,GO:0046538,GO:0046689,GO:0061621,GO:0070062" "bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein binding|nucleus|cytosol|gluconeogenesis|glycolytic process|striated muscle contraction|Notch signaling pathway|spermatogenesis|hydrolase activity|identical protein binding|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity|response to mercury ion|canonical glycolysis|extracellular exosome" "hsa00010,hsa00260,hsa04922,hsa05230" "Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism|Glucagon signaling pathway|Central carbon metabolism in cancer" PGAM4 99.27813302 118.7498483 79.80641774 0.672054903 -0.573348998 0.401207908 1 3.558734256 2.494688024 441531 phosphoglycerate mutase family member 4 "GO:0004082,GO:0004619,GO:0006096,GO:0016787,GO:0070062,GO:0097228,GO:1902093" bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|glycolytic process|hydrolase activity|extracellular exosome|sperm principal piece|positive regulation of flagellated sperm motility "hsa00010,hsa00260,hsa04922,hsa05230" "Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism|Glucagon signaling pathway|Central carbon metabolism in cancer" PGAM5 1258.535253 1539.688204 977.3823012 0.634792355 -0.655643341 0.054010681 1 24.23990545 16.05012944 192111 "PGAM family member 5, mitochondrial serine/threonine protein phosphatase" "GO:0004722,GO:0005096,GO:0005515,GO:0005739,GO:0005741,GO:0006470,GO:0016021,GO:0016236,GO:0016791,GO:0043547,GO:0044877,GO:0070266,GO:0106306,GO:0106307,GO:0120163" protein serine/threonine phosphatase activity|GTPase activator activity|protein binding|mitochondrion|mitochondrial outer membrane|protein dephosphorylation|integral component of membrane|macroautophagy|phosphatase activity|positive regulation of GTPase activity|protein-containing complex binding|necroptotic process|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of cold-induced thermogenesis "hsa04137,hsa04217,hsa04668" Mitophagy - animal|Necroptosis|TNF signaling pathway PGAP1 539.6086874 584.6146378 494.6027371 0.846032078 -0.241215729 0.549015696 1 2.507509232 2.212815988 80055 post-GPI attachment to proteins inositol deacylase 1 "GO:0005783,GO:0005789,GO:0006505,GO:0006888,GO:0007605,GO:0009880,GO:0009948,GO:0015031,GO:0016021,GO:0016255,GO:0016788,GO:0021871,GO:0050185,GO:1902953" "endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor metabolic process|endoplasmic reticulum to Golgi vesicle-mediated transport|sensory perception of sound|embryonic pattern specification|anterior/posterior axis specification|protein transport|integral component of membrane|attachment of GPI anchor to protein|hydrolase activity, acting on ester bonds|forebrain regionalization|phosphatidylinositol deacylase activity|positive regulation of ER to Golgi vesicle-mediated transport" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PGAP2 337.1977168 386.698224 287.6972096 0.743983788 -0.42665691 0.350172718 1 4.88036403 3.787316671 27315 post-GPI attachment to proteins 2 "GO:0000139,GO:0005515,GO:0005789,GO:0006506,GO:0016021" Golgi membrane|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane PGAP3 211.5752659 218.2155332 204.9349986 0.939140288 -0.090587413 0.872365982 1 3.906626701 3.826910587 93210 post-GPI attachment to proteins phospholipase 3 "GO:0000139,GO:0005515,GO:0006505,GO:0006506,GO:0016021,GO:0016788,GO:0031227" "Golgi membrane|protein binding|GPI anchor metabolic process|GPI anchor biosynthetic process|integral component of membrane|hydrolase activity, acting on ester bonds|intrinsic component of endoplasmic reticulum membrane" PGAP4 891.4423559 894.1762081 888.7085037 0.993885205 -0.008848867 0.983875319 1 9.464340748 9.811660745 84302 post-GPI attachment to proteins GalNAc transferase 4 "GO:0000139,GO:0006506,GO:0016021,GO:0016757" "Golgi membrane|GPI anchor biosynthetic process|integral component of membrane|transferase activity, transferring glycosyl groups" PGAP6 1767.262258 1697.006379 1837.518137 1.082799782 0.114766502 0.725498681 1 23.14769362 26.14398675 58986 post-glycosylphosphatidylinositol attachment to proteins 6 "GO:0003674,GO:0004623,GO:0005515,GO:0005765,GO:0005886,GO:0005887,GO:0008150,GO:0070062,GO:0102567,GO:0102568" "molecular_function|phospholipase A2 activity|protein binding|lysosomal membrane|plasma membrane|integral component of plasma membrane|biological_process|extracellular exosome|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" PGBD1 337.1464985 282.1577592 392.1352378 1.389773008 0.474849267 0.298311906 1 3.345106533 4.849196197 84547 piggyBac transposable element derived 1 "GO:0000978,GO:0000981,GO:0005044,GO:0005515,GO:0006357,GO:0006897,GO:0016020,GO:0042802" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|scavenger receptor activity|protein binding|regulation of transcription by RNA polymerase II|endocytosis|membrane|identical protein binding" PGBD2 103.637594 113.6750685 93.60011957 0.8234006 -0.280333595 0.683940979 1 1.915887253 1.645496856 267002 piggyBac transposable element derived 2 GO:0043565 sequence-specific DNA binding PGBD4 58.18454047 71.04691779 45.32216316 0.637918781 -0.648555342 0.426746435 1 0.544863075 0.362550656 161779 piggyBac transposable element derived 4 PGD 3726.90989 3883.221535 3570.598246 0.919493831 -0.1210882 0.704060992 1 86.71581639 83.16930391 5226 phosphogluconate dehydrogenase "GO:0004616,GO:0005634,GO:0005829,GO:0006098,GO:0009051,GO:0019322,GO:0046177,GO:0050661,GO:0055114,GO:0070062" "phosphogluconate dehydrogenase (decarboxylating) activity|nucleus|cytosol|pentose-phosphate shunt|pentose-phosphate shunt, oxidative branch|pentose biosynthetic process|D-gluconate catabolic process|NADP binding|oxidation-reduction process|extracellular exosome" "hsa00030,hsa00480" Pentose phosphate pathway|Glutathione metabolism PGF 323.0922537 365.3841486 280.8003587 0.768507227 -0.379869269 0.412120061 1 10.61090489 8.505822337 5228 placental growth factor "GO:0001666,GO:0001934,GO:0001938,GO:0002040,GO:0005172,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007267,GO:0008083,GO:0008201,GO:0008284,GO:0016020,GO:0030154,GO:0038084,GO:0042056,GO:0045766,GO:0048010,GO:0050918,GO:0050930,GO:0051781,GO:0060754" response to hypoxia|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|sprouting angiogenesis|vascular endothelial growth factor receptor binding|protein binding|extracellular region|extracellular space|signal transduction|cell-cell signaling|growth factor activity|heparin binding|positive regulation of cell population proliferation|membrane|cell differentiation|vascular endothelial growth factor signaling pathway|chemoattractant activity|positive regulation of angiogenesis|vascular endothelial growth factor receptor signaling pathway|positive chemotaxis|induction of positive chemotaxis|positive regulation of cell division|positive regulation of mast cell chemotaxis "hsa04010,hsa04014,hsa04015,hsa04151,hsa04510,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Pathways in cancer PGGHG 399.8389577 358.2794568 441.3984586 1.231994886 0.300996268 0.489230188 1 3.692631371 4.745268486 80162 protein-glucosylgalactosylhydroxylysine glucosidase "GO:0004553,GO:0005829,GO:0005975,GO:0018215,GO:0047402" "hydrolase activity, hydrolyzing O-glycosyl compounds|cytosol|carbohydrate metabolic process|protein phosphopantetheinylation|protein-glucosylgalactosylhydroxylysine glucosidase activity" PGGT1B 331.6775637 346.0999852 317.2551421 0.916657485 -0.125545332 0.789239893 1 1.316070522 1.258352107 5229 protein geranylgeranyltransferase type I subunit beta "GO:0004661,GO:0004662,GO:0005515,GO:0005953,GO:0008144,GO:0008270,GO:0008284,GO:0018215,GO:0018342,GO:0018344,GO:0019840,GO:0034097,GO:0042277,GO:0045787,GO:0051771" protein geranylgeranyltransferase activity|CAAX-protein geranylgeranyltransferase activity|protein binding|CAAX-protein geranylgeranyltransferase complex|drug binding|zinc ion binding|positive regulation of cell population proliferation|protein phosphopantetheinylation|protein prenylation|protein geranylgeranylation|isoprenoid binding|response to cytokine|peptide binding|positive regulation of cell cycle|negative regulation of nitric-oxide synthase biosynthetic process PGK1 18285.20914 22409.21283 14161.20546 0.631936765 -0.662147893 0.066307549 1 235.857767 155.4675429 5230 phosphoglycerate kinase 1 "GO:0004618,GO:0005515,GO:0005524,GO:0005615,GO:0005829,GO:0006094,GO:0006096,GO:0016020,GO:0016310,GO:0016525,GO:0030855,GO:0031639,GO:0043531,GO:0045121,GO:0047134,GO:0061621,GO:0070062,GO:0071456" phosphoglycerate kinase activity|protein binding|ATP binding|extracellular space|cytosol|gluconeogenesis|glycolytic process|membrane|phosphorylation|negative regulation of angiogenesis|epithelial cell differentiation|plasminogen activation|ADP binding|membrane raft|protein-disulfide reductase activity|canonical glycolysis|extracellular exosome|cellular response to hypoxia "hsa00010,hsa04066" Glycolysis / Gluconeogenesis|HIF-1 signaling pathway PGLS 669.5757535 747.0075927 592.1439143 0.792687946 -0.335175057 0.379914551 1 19.37188904 16.01733123 25796 6-phosphogluconolactonase "GO:0005515,GO:0005737,GO:0005829,GO:0005975,GO:0006098,GO:0009051,GO:0017057,GO:0070062" "protein binding|cytoplasm|cytosol|carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, oxidative branch|6-phosphogluconolactonase activity|extracellular exosome" hsa00030 Pentose phosphate pathway PGM1 2895.722073 3673.12565 2118.318496 0.576707333 -0.794088729 0.013017297 0.50554854 57.80946431 34.77525698 5236 phosphoglucomutase 1 "GO:0000287,GO:0004614,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0005975,GO:0005978,GO:0005980,GO:0006006,GO:0006094,GO:0006096,GO:0019388,GO:0043312,GO:0070062,GO:1904724,GO:1904813" magnesium ion binding|phosphoglucomutase activity|protein binding|extracellular region|cytoplasm|cytosol|carbohydrate metabolic process|glycogen biosynthetic process|glycogen catabolic process|glucose metabolic process|gluconeogenesis|glycolytic process|galactose catabolic process|neutrophil degranulation|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen "hsa00010,hsa00030,hsa00052,hsa00230,hsa00500,hsa00520" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Galactose metabolism|Purine metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism PGM2 616.812889 642.467128 591.1586499 0.920138361 -0.12007728 0.760198284 1 9.632532133 9.245055721 55276 phosphoglucomutase 2 "GO:0000287,GO:0004614,GO:0005515,GO:0005576,GO:0005829,GO:0005978,GO:0005980,GO:0006006,GO:0006098,GO:0008973,GO:0019388,GO:0034774,GO:0043312,GO:0046386,GO:0070062,GO:1904813" magnesium ion binding|phosphoglucomutase activity|protein binding|extracellular region|cytosol|glycogen biosynthetic process|glycogen catabolic process|glucose metabolic process|pentose-phosphate shunt|phosphopentomutase activity|galactose catabolic process|secretory granule lumen|neutrophil degranulation|deoxyribose phosphate catabolic process|extracellular exosome|ficolin-1-rich granule lumen "hsa00010,hsa00030,hsa00052,hsa00230,hsa00500,hsa00520" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Galactose metabolism|Purine metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism PGM2L1 617.2597461 470.9395693 763.5799228 1.621396826 0.697237224 0.073170964 1 2.792907238 4.723476507 283209 phosphoglucomutase 2 like 1 "GO:0005829,GO:0005978,GO:0005980,GO:0016868,GO:0019388,GO:0046872,GO:0047933,GO:0061621" "cytosol|glycogen biosynthetic process|glycogen catabolic process|intramolecular transferase activity, phosphotransferases|galactose catabolic process|metal ion binding|glucose-1,6-bisphosphate synthase activity|canonical glycolysis" hsa00500 Starch and sucrose metabolism PGM3 1171.891613 1173.289099 1170.494127 0.997617831 -0.003440843 0.994840821 1 9.435210189 9.81819633 5238 phosphoglucomutase 3 "GO:0000287,GO:0004610,GO:0004614,GO:0005575,GO:0005829,GO:0005975,GO:0006041,GO:0006048,GO:0006487,GO:0006493,GO:0007283,GO:0019255,GO:0030097" magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity|cellular_component|cytosol|carbohydrate metabolic process|glucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|protein N-linked glycosylation|protein O-linked glycosylation|spermatogenesis|glucose 1-phosphate metabolic process|hemopoiesis hsa00520 Amino sugar and nucleotide sugar metabolism PGP 606.8293544 599.8389773 613.8197315 1.023307512 0.033239752 0.936460557 1 9.601683975 10.24871697 283871 phosphoglycolate phosphatase "GO:0000121,GO:0000287,GO:0004725,GO:0005737,GO:0006114,GO:0006650,GO:0008967,GO:0016311,GO:0016791,GO:0035335,GO:0043136,GO:0045721,GO:0098519" "glycerol-1-phosphatase activity|magnesium ion binding|protein tyrosine phosphatase activity|cytoplasm|glycerol biosynthetic process|glycerophospholipid metabolic process|phosphoglycolate phosphatase activity|dephosphorylation|phosphatase activity|peptidyl-tyrosine dephosphorylation|glycerol-3-phosphatase activity|negative regulation of gluconeogenesis|nucleotide phosphatase activity, acting on free nucleotides" hsa00630 Glyoxylate and dicarboxylate metabolism PGPEP1 686.1498209 701.3345741 670.9650677 0.956697548 -0.063865194 0.869806428 1 4.931980286 4.921663564 54858 pyroglutamyl-peptidase I "GO:0005829,GO:0006508,GO:0016920" cytosol|proteolysis|pyroglutamyl-peptidase activity PGRMC1 1731.753645 1626.974417 1836.532872 1.128802551 0.174793153 0.592722174 1 43.85338724 51.63415282 10857 progesterone receptor membrane component 1 "GO:0001540,GO:0005496,GO:0005515,GO:0005741,GO:0005783,GO:0005886,GO:0005887,GO:0006783,GO:0012505,GO:0016020,GO:0020037,GO:0030868,GO:0035579,GO:0042803,GO:0043005,GO:0043025,GO:0043312,GO:0044297,GO:0045202,GO:0046872" amyloid-beta binding|steroid binding|protein binding|mitochondrial outer membrane|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|heme biosynthetic process|endomembrane system|membrane|heme binding|smooth endoplasmic reticulum membrane|specific granule membrane|protein homodimerization activity|neuron projection|neuronal cell body|neutrophil degranulation|cell body|synapse|metal ion binding PGRMC2 1021.9169 1057.584119 986.249681 0.932549632 -0.100747585 0.776139712 1 15.92238546 15.48802419 10424 progesterone receptor membrane component 2 "GO:0003707,GO:0005496,GO:0005515,GO:0005635,GO:0005783,GO:0012505,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0020037,GO:0043401,GO:0060612" steroid hormone receptor activity|steroid binding|protein binding|nuclear envelope|endoplasmic reticulum|endomembrane system|heme transmembrane transporter activity|heme transport|membrane|integral component of membrane|heme binding|steroid hormone mediated signaling pathway|adipose tissue development PGS1 653.6591057 601.8688892 705.4493222 1.172098001 0.229093201 0.551534484 1 4.523973876 5.530952688 9489 phosphatidylglycerophosphate synthase 1 "GO:0005509,GO:0005524,GO:0005739,GO:0005743,GO:0005783,GO:0006655,GO:0008444,GO:0032049,GO:0046339" calcium ion binding|ATP binding|mitochondrion|mitochondrial inner membrane|endoplasmic reticulum|phosphatidylglycerol biosynthetic process|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity|cardiolipin biosynthetic process|diacylglycerol metabolic process hsa00564 Glycerophospholipid metabolism PHACTR1 79.02355098 81.19647747 76.85062449 0.946477321 -0.079360157 0.931536405 1 0.621289491 0.613366637 221692 phosphatase and actin regulator 1 "GO:0003779,GO:0004864,GO:0005515,GO:0005634,GO:0005829,GO:0008157,GO:0021987,GO:0030036,GO:0031032,GO:0031532,GO:0032515,GO:0043149,GO:0045202,GO:0048870,GO:0140059,GO:2001222" actin binding|protein phosphatase inhibitor activity|protein binding|nucleus|cytosol|protein phosphatase 1 binding|cerebral cortex development|actin cytoskeleton organization|actomyosin structure organization|actin cytoskeleton reorganization|negative regulation of phosphoprotein phosphatase activity|stress fiber assembly|synapse|cell motility|dendrite arborization|regulation of neuron migration PHACTR2 521.2652511 543.0014431 499.5290592 0.919940574 -0.120387426 0.76938691 1 2.813124744 2.699384155 9749 phosphatase and actin regulator 2 "GO:0002576,GO:0003779,GO:0004864,GO:0005515,GO:0005886,GO:0030036,GO:0031092,GO:0032515" platelet degranulation|actin binding|protein phosphatase inhibitor activity|protein binding|plasma membrane|actin cytoskeleton organization|platelet alpha granule membrane|negative regulation of phosphoprotein phosphatase activity PHACTR4 1018.085206 997.7017169 1038.468695 1.040860888 0.057777264 0.871905569 1 7.830477651 8.501525732 65979 phosphatase and actin regulator 4 "GO:0001755,GO:0001843,GO:0003779,GO:0005737,GO:0007266,GO:0008157,GO:0030027,GO:0030036,GO:0043085,GO:0043666,GO:0048484,GO:0051726,GO:0061386,GO:0072542,GO:2001045" neural crest cell migration|neural tube closure|actin binding|cytoplasm|Rho protein signal transduction|protein phosphatase 1 binding|lamellipodium|actin cytoskeleton organization|positive regulation of catalytic activity|regulation of phosphoprotein phosphatase activity|enteric nervous system development|regulation of cell cycle|closure of optic fissure|protein phosphatase activator activity|negative regulation of integrin-mediated signaling pathway PHAF1 377.893195 373.5037964 382.2825936 1.023503904 0.033516605 0.945747196 1 4.65812599 4.972979443 80262 phagosome assembly factor 1 PHAX 709.3817229 841.3984978 577.3649481 0.68619679 -0.543305718 0.14936127 1 11.80766573 8.451400092 51808 phosphorylated adaptor for RNA export "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006408,GO:0015030,GO:0015031,GO:0015643,GO:0042795,GO:0043025,GO:0051168" RNA binding|protein binding|nucleus|nucleoplasm|centrosome|cytosol|snRNA export from nucleus|Cajal body|protein transport|toxic substance binding|snRNA transcription by RNA polymerase II|neuronal cell body|nuclear export hsa03013 RNA transport PHB 4382.210196 4496.25494 4268.165452 0.949271229 -0.075107737 0.814628855 1 112.6766209 111.5681065 5245 prohibitin "GO:0000122,GO:0001541,GO:0001552,GO:0001649,GO:0001850,GO:0001851,GO:0002377,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005769,GO:0005886,GO:0005887,GO:0006355,GO:0006851,GO:0007005,GO:0007165,GO:0007202,GO:0008022,GO:0008285,GO:0009986,GO:0010628,GO:0010942,GO:0010944,GO:0014069,GO:0016020,GO:0016575,GO:0019899,GO:0023035,GO:0030061,GO:0030308,GO:0031100,GO:0031315,GO:0031871,GO:0032620,GO:0035632,GO:0035902,GO:0039529,GO:0042113,GO:0042177,GO:0042493,GO:0042826,GO:0042981,GO:0043066,GO:0043434,GO:0044830,GO:0045471,GO:0045745,GO:0045892,GO:0045893,GO:0045917,GO:0046718,GO:0046982,GO:0048661,GO:0050821,GO:0050847,GO:0051897,GO:0060766,GO:0070062,GO:0070373,GO:0070374,GO:0071354,GO:0071897,GO:0072538,GO:0098891,GO:0098978,GO:0098982,GO:0140374,GO:1901224,GO:1990051,GO:2000323" "negative regulation of transcription by RNA polymerase II|ovarian follicle development|ovarian follicle atresia|osteoblast differentiation|complement component C3a binding|complement component C3b binding|immunoglobulin production|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|early endosome|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|mitochondrial calcium ion transmembrane transport|mitochondrion organization|signal transduction|activation of phospholipase C activity|protein C-terminus binding|negative regulation of cell population proliferation|cell surface|positive regulation of gene expression|positive regulation of cell death|negative regulation of transcription by competitive promoter binding|postsynaptic density|membrane|histone deacetylation|enzyme binding|CD40 signaling pathway|mitochondrial crista|negative regulation of cell growth|animal organ regeneration|extrinsic component of mitochondrial outer membrane|proteinase activated receptor binding|interleukin-17 production|mitochondrial prohibitin complex|response to immobilization stress|RIG-I signaling pathway|B cell activation|negative regulation of protein catabolic process|response to drug|histone deacetylase binding|regulation of apoptotic process|negative regulation of apoptotic process|response to peptide hormone|modulation by host of viral RNA genome replication|response to ethanol|positive regulation of G protein-coupled receptor signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of complement activation|viral entry into host cell|protein heterodimerization activity|positive regulation of smooth muscle cell proliferation|protein stabilization|progesterone receptor signaling pathway|positive regulation of protein kinase B signaling|negative regulation of androgen receptor signaling pathway|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to interleukin-6|DNA biosynthetic process|T-helper 17 type immune response|extrinsic component of presynaptic active zone membrane|glutamatergic synapse|GABA-ergic synapse|antiviral innate immune response|positive regulation of NIK/NF-kappaB signaling|activation of protein kinase C activity|negative regulation of glucocorticoid receptor signaling pathway" PHB2 4587.068244 4524.673707 4649.462782 1.027579685 0.039250274 0.902987406 1 157.1733616 168.4652696 11331 prohibitin 2 "GO:0000187,GO:0000423,GO:0002377,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005886,GO:0006606,GO:0006851,GO:0007005,GO:0007062,GO:0007202,GO:0008022,GO:0009611,GO:0009986,GO:0014069,GO:0016363,GO:0016477,GO:0023035,GO:0030331,GO:0030424,GO:0030449,GO:0031536,GO:0032991,GO:0033147,GO:0033218,GO:0033600,GO:0035632,GO:0039520,GO:0039529,GO:0042113,GO:0042802,GO:0042803,GO:0043066,GO:0043433,GO:0045892,GO:0046625,GO:0046982,GO:0047485,GO:0048786,GO:0050821,GO:0051091,GO:0060744,GO:0060749,GO:0060762,GO:0070374,GO:0071300,GO:0071456,GO:0071944,GO:0098978,GO:0098982,GO:0140374,GO:1900208,GO:1901224,GO:1902808,GO:1904959,GO:1990051" "activation of MAPK activity|mitophagy|immunoglobulin production|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|plasma membrane|protein import into nucleus|mitochondrial calcium ion transmembrane transport|mitochondrion organization|sister chromatid cohesion|activation of phospholipase C activity|protein C-terminus binding|response to wounding|cell surface|postsynaptic density|nuclear matrix|cell migration|CD40 signaling pathway|estrogen receptor binding|axon|regulation of complement activation|positive regulation of exit from mitosis|protein-containing complex|negative regulation of intracellular estrogen receptor signaling pathway|amide binding|negative regulation of mammary gland epithelial cell proliferation|mitochondrial prohibitin complex|induction by virus of host autophagy|RIG-I signaling pathway|B cell activation|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|negative regulation of DNA-binding transcription factor activity|negative regulation of transcription, DNA-templated|sphingolipid binding|protein heterodimerization activity|protein N-terminus binding|presynaptic active zone|protein stabilization|positive regulation of DNA-binding transcription factor activity|mammary gland branching involved in thelarche|mammary gland alveolus development|regulation of branching involved in mammary gland duct morphogenesis|positive regulation of ERK1 and ERK2 cascade|cellular response to retinoic acid|cellular response to hypoxia|cell periphery|glutamatergic synapse|GABA-ergic synapse|antiviral innate immune response|regulation of cardiolipin metabolic process|positive regulation of NIK/NF-kappaB signaling|positive regulation of cell cycle G1/S phase transition|regulation of cytochrome-c oxidase activity|activation of protein kinase C activity" PHC1 702.1070467 714.5290017 689.6850916 0.965230368 -0.051054788 0.896035085 1 6.591689113 6.636569143 1911 polyhomeotic homolog 1 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0007275,GO:0008270,GO:0016574,GO:0031519,GO:0035102,GO:0042393,GO:0045892,GO:0070317" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|multicellular organism development|zinc ion binding|histone ubiquitination|PcG protein complex|PRC1 complex|histone binding|negative regulation of transcription, DNA-templated|negative regulation of G0 to G1 transition" PHC2 3522.763448 3364.579035 3680.94786 1.094029245 0.129651303 0.684020703 1 38.23290523 43.62969343 1912 polyhomeotic homolog 2 "GO:0000792,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0007275,GO:0007283,GO:0008270,GO:0031519,GO:0035102,GO:0042393,GO:0042802,GO:0045892" "heterochromatin|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|multicellular organism development|spermatogenesis|zinc ion binding|PcG protein complex|PRC1 complex|histone binding|identical protein binding|negative regulation of transcription, DNA-templated" PHC3 1516.685416 1405.714016 1627.656816 1.157886168 0.211493429 0.523460088 1 5.489163906 6.629610212 80012 polyhomeotic homolog 3 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0007275,GO:0008270,GO:0031519,GO:0035102,GO:0042393,GO:0045892,GO:0070317" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|multicellular organism development|zinc ion binding|PcG protein complex|PRC1 complex|histone binding|negative regulation of transcription, DNA-templated|negative regulation of G0 to G1 transition" PHETA1 717.9630736 687.1251906 748.8009566 1.08975914 0.124009304 0.743818195 1 9.347425966 10.62523353 144717 PH domain containing endocytic trafficking adaptor 1 "GO:0001881,GO:0005515,GO:0005769,GO:0005802,GO:0005829,GO:0007032,GO:0030136,GO:0042147,GO:0042803,GO:0055037" "receptor recycling|protein binding|early endosome|trans-Golgi network|cytosol|endosome organization|clathrin-coated vesicle|retrograde transport, endosome to Golgi|protein homodimerization activity|recycling endosome" PHETA2 172.974526 172.5425146 173.4065373 1.005007593 0.007206401 1 1 3.537922944 3.708801948 150368 PH domain containing endocytic trafficking adaptor 2 "GO:0001881,GO:0005515,GO:0005769,GO:0005802,GO:0005829,GO:0007032,GO:0030136,GO:0042147,GO:0042803,GO:0055037" "receptor recycling|protein binding|early endosome|trans-Golgi network|cytosol|endosome organization|clathrin-coated vesicle|retrograde transport, endosome to Golgi|protein homodimerization activity|recycling endosome" PHEX 18.19497855 31.46363502 4.926322083 0.156571931 -2.675102497 0.02951275 0.763169617 0.226932799 0.037061851 5251 phosphate regulating endopeptidase homolog X-linked "GO:0001501,GO:0004222,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006464,GO:0006508,GO:0007267,GO:0008270,GO:0016485,GO:0019637,GO:0030282,GO:0030324,GO:0042476,GO:0048471,GO:0060348,GO:0060416,GO:0071305,GO:0071374,GO:1904383,GO:1990418" skeletal system development|metalloendopeptidase activity|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|cellular protein modification process|proteolysis|cell-cell signaling|zinc ion binding|protein processing|organophosphate metabolic process|bone mineralization|lung development|odontogenesis|perinuclear region of cytoplasm|bone development|response to growth hormone|cellular response to vitamin D|cellular response to parathyroid hormone stimulus|response to sodium phosphate|response to insulin-like growth factor stimulus PHF1 847.4471561 547.061267 1147.833045 2.098180066 1.069138496 0.003518905 0.213879991 11.43016636 25.01561808 5252 PHD finger protein 1 "GO:0001226,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006325,GO:0006355,GO:0006974,GO:0035064,GO:0035098,GO:0035861,GO:0042802,GO:0045814,GO:0046872,GO:0061086,GO:0061087,GO:1990226" "RNA polymerase II transcription corepressor binding|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|chromatin organization|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|methylated histone binding|ESC/E(Z) complex|site of double-strand break|identical protein binding|negative regulation of gene expression, epigenetic|metal ion binding|negative regulation of histone H3-K27 methylation|positive regulation of histone H3-K27 methylation|histone methyltransferase binding" PHF10 800.8885881 698.2897062 903.48747 1.293857638 0.371678888 0.311801877 1 16.32021698 22.02563065 55274 PHD finger protein 10 "GO:0003712,GO:0005654,GO:0007399,GO:0042393,GO:0045892,GO:0045944,GO:0046872,GO:0071564" "transcription coregulator activity|nucleoplasm|nervous system development|histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|npBAF complex" hsa05225 Hepatocellular carcinoma PHF11 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.100529216 0.169653402 51131 PHD finger protein 11 "GO:0005515,GO:0005634,GO:0005654,GO:0031965,GO:0046872" protein binding|nucleus|nucleoplasm|nuclear membrane|metal ion binding PHF12 1779.312077 1847.219862 1711.404292 0.926475687 -0.110174978 0.735956716 1 15.63944658 15.1137188 57649 PHD finger protein 12 "GO:0000122,GO:0001222,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0016580,GO:0017053,GO:0035091,GO:0045892,GO:0046872,GO:0070822" "negative regulation of transcription by RNA polymerase II|transcription corepressor binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|Sin3 complex|transcription repressor complex|phosphatidylinositol binding|negative regulation of transcription, DNA-templated|metal ion binding|Sin3-type complex" PHF13 1052.507356 1027.13544 1077.879272 1.049403253 0.069569167 0.844470401 1 13.65016702 14.94157232 148479 PHD finger protein 13 "GO:0000278,GO:0003682,GO:0005634,GO:0005654,GO:0006325,GO:0007059,GO:0007076,GO:0035064,GO:0046872,GO:0051301" mitotic cell cycle|chromatin binding|nucleus|nucleoplasm|chromatin organization|chromosome segregation|mitotic chromosome condensation|methylated histone binding|metal ion binding|cell division PHF14 986.1328981 1069.763591 902.5022056 0.843646403 -0.245289645 0.488067968 1 4.810419246 4.233107694 9678 PHD finger protein 14 "GO:0005515,GO:0006357,GO:0042393,GO:0043972,GO:0043994,GO:0044154,GO:0046872,GO:0070776" protein binding|regulation of transcription by RNA polymerase II|histone binding|histone H3-K23 acetylation|histone acetyltransferase activity (H3-K23 specific)|histone H3-K14 acetylation|metal ion binding|MOZ/MORF histone acetyltransferase complex PHF19 2772.173571 2231.888174 3312.458968 1.484150956 0.569637839 0.074179246 1 19.6654945 30.44380121 26147 PHD finger protein 19 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006355,GO:0035064,GO:0035098,GO:0045814,GO:0046872,GO:0061087" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|chromatin organization|regulation of transcription, DNA-templated|methylated histone binding|ESC/E(Z) complex|negative regulation of gene expression, epigenetic|metal ion binding|positive regulation of histone H3-K27 methylation" PHF2 1265.001822 1139.795552 1390.208092 1.219699523 0.286525779 0.398741358 1 10.70002294 13.61298897 5253 PHD finger protein 2 "GO:0000776,GO:0000777,GO:0001889,GO:0003712,GO:0003713,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0006482,GO:0008270,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0045893,GO:0051213,GO:0055114,GO:0061188" "kinetochore|condensed chromosome kinetochore|liver development|transcription coregulator activity|transcription coactivator activity|iron ion binding|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|protein demethylation|zinc ion binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|positive regulation of transcription, DNA-templated|dioxygenase activity|oxidation-reduction process|negative regulation of ribosomal DNA heterochromatin assembly" PHF20 2085.993813 1898.982617 2273.005009 1.196959355 0.259374164 0.419797881 1 15.22989237 19.01481776 51230 PHD finger protein 20 "GO:0000123,GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0016573,GO:0031965,GO:0043981,GO:0043982,GO:0043984,GO:0044545,GO:0046872,GO:0071339,GO:1901796" histone acetyltransferase complex|DNA binding|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|histone acetylation|nuclear membrane|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex|metal ion binding|MLL1 complex|regulation of signal transduction by p53 class mediator other PHF20L1 1545.275406 1743.694354 1346.856457 0.772415449 -0.372551075 0.259517358 1 9.600170413 7.734741851 51105 PHD finger protein 20 like 1 "GO:0005515,GO:0006357,GO:0016573,GO:0044545,GO:0046872" protein binding|regulation of transcription by RNA polymerase II|histone acetylation|NSL complex|metal ion binding PHF21A 1345.149693 1163.13954 1527.159846 1.312963573 0.39282689 0.24298627 1 7.614906202 10.42877181 51317 PHD finger protein 21A "GO:0000118,GO:0000122,GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0006325,GO:0007596,GO:0046872,GO:1990391" histone deacetylase complex|negative regulation of transcription by RNA polymerase II|DNA binding|chromatin binding|protein binding|nucleoplasm|chromatin organization|blood coagulation|metal ion binding|DNA repair complex PHF21B 233.1174711 209.0809295 257.1540127 1.22992572 0.298571188 0.563643631 1 2.156662217 2.766794751 112885 PHD finger protein 21B GO:0046872 metal ion binding PHF23 1203.723671 1295.083816 1112.363526 0.858912383 -0.219417124 0.521639442 1 24.66770458 22.10006406 79142 PHD finger protein 23 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006914,GO:0031398,GO:0046872,GO:1901097,GO:1902902" protein binding|nucleus|nucleoplasm|cytoplasm|autophagy|positive regulation of protein ubiquitination|metal ion binding|negative regulation of autophagosome maturation|negative regulation of autophagosome assembly PHF3 1901.861452 1805.606668 1998.116237 1.106617666 0.14615686 0.652122381 1 4.677148523 5.39876831 23469 PHD finger protein 3 "GO:0003674,GO:0005575,GO:0006351,GO:0007275,GO:0046872" "molecular_function|cellular_component|transcription, DNA-templated|multicellular organism development|metal ion binding" PHF5A 936.4027773 936.8043588 936.0011957 0.999142657 -0.001237416 1 1 45.05777391 46.95838606 84844 PHD finger protein 5A "GO:0000398,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005686,GO:0005689,GO:0008270,GO:0016363,GO:0016607,GO:0045893,GO:0048863,GO:0071005,GO:0071011" "mRNA splicing, via spliceosome|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|U2 snRNP|U12-type spliceosomal complex|zinc ion binding|nuclear matrix|nuclear speck|positive regulation of transcription, DNA-templated|stem cell differentiation|U2-type precatalytic spliceosome|precatalytic spliceosome" hsa03040 Spliceosome PHF6 1948.72906 1709.185851 2188.272269 1.28030095 0.356482973 0.269687009 1 18.7978792 25.10364888 84295 PHD finger protein 6 "GO:0000122,GO:0000777,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0015631,GO:0019899,GO:0042393,GO:0042826,GO:0043021,GO:0046872,GO:0051219,GO:0097110" negative regulation of transcription by RNA polymerase II|condensed chromosome kinetochore|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|tubulin binding|enzyme binding|histone binding|histone deacetylase binding|ribonucleoprotein complex binding|metal ion binding|phosphoprotein binding|scaffold protein binding PHF7 57.75401297 41.6131947 73.89483124 1.775754824 0.828432405 0.309262318 1 0.97436963 1.80477336 51533 PHD finger protein 7 "GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0016607,GO:0046872" protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|nuclear speck|metal ion binding PHF8 1247.204958 1169.229276 1325.18064 1.133379627 0.180631175 0.596183737 1 8.41394402 9.946973243 23133 PHD finger protein 8 "GO:0000082,GO:0003682,GO:0003712,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0006482,GO:0007420,GO:0008270,GO:0016706,GO:0031965,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0035574,GO:0035575,GO:0045893,GO:0045943,GO:0051864,GO:0055114,GO:0061188,GO:0070544,GO:0071557,GO:0071558" "G1/S transition of mitotic cell cycle|chromatin binding|transcription coregulator activity|iron ion binding|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|protein demethylation|brain development|zinc ion binding|2-oxoglutarate-dependent dioxygenase activity|nuclear membrane|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|histone H4-K20 demethylation|histone demethylase activity (H4-K20 specific)|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase I|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|negative regulation of ribosomal DNA heterochromatin assembly|histone H3-K36 demethylation|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific)" other PHGDH 3143.86247 2349.623067 3938.101873 1.676056866 0.745071098 0.019660636 0.604436841 16.23909926 28.39007995 26227 phosphoglycerate dehydrogenase "GO:0004617,GO:0005829,GO:0006520,GO:0006541,GO:0006544,GO:0006564,GO:0006566,GO:0007420,GO:0009055,GO:0009448,GO:0010468,GO:0019530,GO:0021510,GO:0021782,GO:0021915,GO:0022900,GO:0030060,GO:0031175,GO:0051287,GO:0070062,GO:0070314" phosphoglycerate dehydrogenase activity|cytosol|cellular amino acid metabolic process|glutamine metabolic process|glycine metabolic process|L-serine biosynthetic process|threonine metabolic process|brain development|electron transfer activity|gamma-aminobutyric acid metabolic process|regulation of gene expression|taurine metabolic process|spinal cord development|glial cell development|neural tube development|electron transport chain|L-malate dehydrogenase activity|neuron projection development|NAD binding|extracellular exosome|G1 to G0 transition "hsa00260,hsa00270" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism" PHIP 1943.055006 1725.425146 2160.684865 1.252262302 0.324536784 0.315054029 1 7.221444238 9.432684283 55023 pleckstrin homology domain interacting protein "GO:0001932,GO:0005158,GO:0005515,GO:0005634,GO:0006357,GO:0007010,GO:0008284,GO:0008286,GO:0008360,GO:0022604,GO:0043066,GO:0043568,GO:0045840,GO:0045893,GO:0045944,GO:0070577,GO:2001237" "regulation of protein phosphorylation|insulin receptor binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|cytoskeleton organization|positive regulation of cell population proliferation|insulin receptor signaling pathway|regulation of cell shape|regulation of cell morphogenesis|negative regulation of apoptotic process|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lysine-acetylated histone binding|negative regulation of extrinsic apoptotic signaling pathway" PHKA1 688.1851761 638.4073041 737.963048 1.15594393 0.20907142 0.582785224 1 5.386153221 6.494285877 5255 phosphorylase kinase regulatory subunit alpha 1 "GO:0004689,GO:0005516,GO:0005829,GO:0005886,GO:0005964,GO:0005977,GO:0005980,GO:0006091,GO:0006468" phosphorylase kinase activity|calmodulin binding|cytosol|plasma membrane|phosphorylase kinase complex|glycogen metabolic process|glycogen catabolic process|generation of precursor metabolites and energy|protein phosphorylation "hsa04020,hsa04910,hsa04922" Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKA2 774.8775583 772.3814919 777.3736247 1.006463299 0.009294565 0.983865485 1 7.68685356 8.069794589 5256 phosphorylase kinase regulatory subunit alpha 2 "GO:0004689,GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0005964,GO:0005975,GO:0005980,GO:0006091,GO:0006464,GO:0006468" phosphorylase kinase activity|protein binding|calmodulin binding|cytosol|plasma membrane|phosphorylase kinase complex|carbohydrate metabolic process|glycogen catabolic process|generation of precursor metabolites and energy|cellular protein modification process|protein phosphorylation "hsa04020,hsa04910,hsa04922" Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKB 787.6184478 868.8023089 706.4345867 0.813113155 -0.298471959 0.418493603 1 7.727743589 6.55419896 5257 phosphorylase kinase regulatory subunit beta "GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0005964,GO:0005977,GO:0005980,GO:0006091,GO:0006468" protein binding|calmodulin binding|cytosol|plasma membrane|phosphorylase kinase complex|glycogen metabolic process|glycogen catabolic process|generation of precursor metabolites and energy|protein phosphorylation "hsa04020,hsa04910,hsa04922" Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKG1 12.03101386 14.20938356 9.852644165 0.693389979 -0.528261108 0.729410839 1 0.217287183 0.157154782 5260 phosphorylase kinase catalytic subunit gamma 1 "GO:0004689,GO:0005516,GO:0005524,GO:0005829,GO:0005964,GO:0005975,GO:0005978,GO:0005980,GO:0006468,GO:0019899,GO:0050321,GO:0106310,GO:0106311" phosphorylase kinase activity|calmodulin binding|ATP binding|cytosol|phosphorylase kinase complex|carbohydrate metabolic process|glycogen biosynthetic process|glycogen catabolic process|protein phosphorylation|enzyme binding|tau-protein kinase activity|protein serine kinase activity|protein threonine kinase activity "hsa04020,hsa04910,hsa04922" Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKG2 506.892564 503.4181603 510.3669678 1.013803251 0.019777696 0.966563599 1 11.45903545 12.11762957 5261 phosphorylase kinase catalytic subunit gamma 2 "GO:0004674,GO:0004689,GO:0005515,GO:0005516,GO:0005524,GO:0005829,GO:0005964,GO:0005977,GO:0005978,GO:0005980,GO:0006091,GO:0006468,GO:0045819,GO:0050321" protein serine/threonine kinase activity|phosphorylase kinase activity|protein binding|calmodulin binding|ATP binding|cytosol|phosphorylase kinase complex|glycogen metabolic process|glycogen biosynthetic process|glycogen catabolic process|generation of precursor metabolites and energy|protein phosphorylation|positive regulation of glycogen catabolic process|tau-protein kinase activity "hsa04020,hsa04910,hsa04922" Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHLDA1 6705.306829 6977.822283 6432.791376 0.921890973 -0.117331953 0.719599241 1 59.76696809 57.47205384 22822 pleckstrin homology like domain family A member 1 "GO:0000086,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006915,GO:0031410,GO:0043065,GO:0045210,GO:1901981" G2/M transition of mitotic cell cycle|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|apoptotic process|cytoplasmic vesicle|positive regulation of apoptotic process|FasL biosynthetic process|phosphatidylinositol phosphate binding PHLDA2 662.148414 845.4583217 478.8385064 0.566365596 -0.820194463 0.032505051 0.806911101 46.54291456 27.49580061 7262 pleckstrin homology like domain family A member 2 "GO:0001890,GO:0005515,GO:0005737,GO:0006915,GO:0009887,GO:0010468,GO:0016020,GO:0030334,GO:0043065,GO:0045995,GO:0060721,GO:0070873,GO:1901981,GO:1903547" placenta development|protein binding|cytoplasm|apoptotic process|animal organ morphogenesis|regulation of gene expression|membrane|regulation of cell migration|positive regulation of apoptotic process|regulation of embryonic development|regulation of spongiotrophoblast cell proliferation|regulation of glycogen metabolic process|phosphatidylinositol phosphate binding|regulation of growth hormone activity PHLDA3 440.5762516 381.6234441 499.5290592 1.308957997 0.388418804 0.358246862 1 7.030877103 9.59955602 23612 pleckstrin homology like domain family A member 3 "GO:0005546,GO:0005547,GO:0005737,GO:0005886,GO:0009653,GO:0010314,GO:0032266,GO:0042771,GO:0043065,GO:0043325,GO:0051898,GO:0080025" "phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|plasma membrane|anatomical structure morphogenesis|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-3-phosphate binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of apoptotic process|phosphatidylinositol-3,4-bisphosphate binding|negative regulation of protein kinase B signaling|phosphatidylinositol-3,5-bisphosphate binding" PHLDB1 1267.830684 1232.156546 1303.504823 1.057905205 0.081210359 0.812619478 1 6.036407646 6.66102777 23187 pleckstrin homology like domain family B member 1 "GO:0010470,GO:0010717,GO:0045180,GO:0070507,GO:1904261" regulation of gastrulation|regulation of epithelial to mesenchymal transition|basal cortex|regulation of microtubule cytoskeleton organization|positive regulation of basement membrane assembly involved in embryonic body morphogenesis PHLDB2 1128.10277 1042.35978 1213.845761 1.164517075 0.219731793 0.525360737 1 8.119324148 9.862378605 90102 pleckstrin homology like domain family B member 2 "GO:0000226,GO:0005515,GO:0005829,GO:0005886,GO:0005925,GO:0010470,GO:0010717,GO:0031252,GO:0045111,GO:0045180,GO:0045184,GO:0045296,GO:0051497,GO:0051895,GO:0070507,GO:1903690,GO:1904261" "microtubule cytoskeleton organization|protein binding|cytosol|plasma membrane|focal adhesion|regulation of gastrulation|regulation of epithelial to mesenchymal transition|cell leading edge|intermediate filament cytoskeleton|basal cortex|establishment of protein localization|cadherin binding|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|negative regulation of wound healing, spreading of epidermal cells|positive regulation of basement membrane assembly involved in embryonic body morphogenesis" PHLDB3 109.8609418 134.9891438 84.73273982 0.627700402 -0.671851962 0.30769812 1 2.084367049 1.364716792 653583 pleckstrin homology like domain family B member 3 GO:0019899 enzyme binding PHLPP1 491.4967562 562.2856065 420.7079059 0.748210342 -0.418484188 0.308174641 1 4.553530915 3.553758619 23239 PH domain and leucine rich repeat protein phosphatase 1 "GO:0002667,GO:0004722,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006470,GO:0006915,GO:0007165,GO:0009649,GO:0042981,GO:0043231,GO:0043408,GO:0046328,GO:0046872,GO:0051898,GO:0106306,GO:0106307,GO:1900744" regulation of T cell anergy|protein serine/threonine phosphatase activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein dephosphorylation|apoptotic process|signal transduction|entrainment of circadian clock|regulation of apoptotic process|intracellular membrane-bounded organelle|regulation of MAPK cascade|regulation of JNK cascade|metal ion binding|negative regulation of protein kinase B signaling|protein serine phosphatase activity|protein threonine phosphatase activity|regulation of p38MAPK cascade hsa04151 PI3K-Akt signaling pathway PHLPP2 668.2193447 721.6336935 614.8049959 0.851962708 -0.231137812 0.545926473 1 4.044284697 3.594001345 23035 PH domain and leucine rich repeat protein phosphatase 2 "GO:0004722,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0007165,GO:0016020,GO:0043231,GO:0045171,GO:0046872,GO:0051898,GO:0072686,GO:0106306,GO:0106307" protein serine/threonine phosphatase activity|protein binding|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|signal transduction|membrane|intracellular membrane-bounded organelle|intercellular bridge|metal ion binding|negative regulation of protein kinase B signaling|mitotic spindle|protein serine phosphatase activity|protein threonine phosphatase activity hsa04151 PI3K-Akt signaling pathway PHOSPHO1 18.13559545 27.40381115 8.867379749 0.32358199 -1.627796782 0.162791174 1 0.606072646 0.204561997 162466 phosphoethanolamine/phosphocholine phosphatase 1 "GO:0001958,GO:0005515,GO:0005829,GO:0006646,GO:0006656,GO:0016311,GO:0016462,GO:0016791,GO:0030500,GO:0031012,GO:0035630,GO:0046872,GO:0052731,GO:0052732,GO:0065010" endochondral ossification|protein binding|cytosol|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|dephosphorylation|pyrophosphatase activity|phosphatase activity|regulation of bone mineralization|extracellular matrix|bone mineralization involved in bone maturation|metal ion binding|phosphocholine phosphatase activity|phosphoethanolamine phosphatase activity|extracellular membrane-bounded organelle hsa00564 Glycerophospholipid metabolism PHOSPHO2 23.56939551 28.41876711 18.72002391 0.65872048 -0.60226169 0.58686198 1 1.263661369 0.868256023 493911 "phosphatase, orphan 2" "GO:0005515,GO:0016311,GO:0016791,GO:0033883,GO:0046872" protein binding|dephosphorylation|phosphatase activity|pyridoxal phosphatase activity|metal ion binding hsa00750 Vitamin B6 metabolism PHPT1 1198.87034 1131.675905 1266.064775 1.118752083 0.161890368 0.637155168 1 90.26046025 105.328847 29085 phosphohistidine phosphatase 1 "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006470,GO:0016604,GO:0019855,GO:0035774,GO:0035971,GO:0044325,GO:0050860,GO:0051350,GO:0070062,GO:0101006,GO:2000147,GO:2000249,GO:2000984" protein binding|nucleoplasm|cytosol|plasma membrane|protein dephosphorylation|nuclear body|calcium channel inhibitor activity|positive regulation of insulin secretion involved in cellular response to glucose stimulus|peptidyl-histidine dephosphorylation|ion channel binding|negative regulation of T cell receptor signaling pathway|negative regulation of lyase activity|extracellular exosome|protein histidine phosphatase activity|positive regulation of cell motility|regulation of actin cytoskeleton reorganization|negative regulation of ATP citrate synthase activity PHRF1 1968.802525 2138.512225 1799.092825 0.841282459 -0.24933783 0.439818101 1 19.50091826 17.11247496 57661 PHD and ring finger domains 1 "GO:0006366,GO:0006397,GO:0016020,GO:0019904,GO:0046872,GO:0070063" transcription by RNA polymerase II|mRNA processing|membrane|protein domain specific binding|metal ion binding|RNA polymerase binding PHTF1 747.6518965 729.7533413 765.5504517 1.049053712 0.069088547 0.856032272 1 8.153415469 8.921815288 10745 putative homeodomain transcription factor 1 "GO:0005789,GO:0005801,GO:0016021" endoplasmic reticulum membrane|cis-Golgi network|integral component of membrane PHTF2 981.4334681 849.5181455 1113.348791 1.31056505 0.390188964 0.269895596 1 6.891734287 9.421130865 57157 putative homeodomain transcription factor 2 "GO:0005783,GO:0016021" endoplasmic reticulum|integral component of membrane PHYH 482.5336208 454.7002738 510.3669678 1.122425028 0.166619084 0.689086398 1 12.17819396 14.25791951 5264 phytanoyl-CoA 2-hydroxylase "GO:0001561,GO:0005515,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006103,GO:0006625,GO:0006720,GO:0008198,GO:0019606,GO:0031406,GO:0031418,GO:0048244,GO:0097089,GO:0097731" fatty acid alpha-oxidation|protein binding|mitochondrion|peroxisome|peroxisomal matrix|cytosol|2-oxoglutarate metabolic process|protein targeting to peroxisome|isoprenoid metabolic process|ferrous iron binding|2-oxobutyrate catabolic process|carboxylic acid binding|L-ascorbic acid binding|phytanoyl-CoA dioxygenase activity|methyl-branched fatty acid metabolic process|9+0 non-motile cilium hsa04146 Peroxisome PHYHIP 33.54080589 36.53841486 30.54319691 0.835920141 -0.258562972 0.811984226 1 0.432875278 0.377436158 9796 phytanoyl-CoA 2-hydroxylase interacting protein "GO:0005737,GO:0008104,GO:1990782" cytoplasm|protein localization|protein tyrosine kinase binding PHYKPL 312.1410221 290.277407 334.0046372 1.150639455 0.202435845 0.668522035 1 3.94142805 4.730519034 85007 5-phosphohydroxy-L-lysine phospho-lyase "GO:0005515,GO:0005759,GO:0006554,GO:0008483,GO:0016829,GO:0030170,GO:0030574,GO:0042802" protein binding|mitochondrial matrix|lysine catabolic process|transaminase activity|lyase activity|pyridoxal phosphate binding|collagen catabolic process|identical protein binding hsa00310 Lysine degradation PI3 58.05092849 61.91231407 54.18954291 0.87526276 -0.192211905 0.830236241 1 5.690817231 5.195519971 5266 peptidase inhibitor 3 "GO:0001533,GO:0004866,GO:0004867,GO:0005576,GO:0005615,GO:0005829,GO:0007620,GO:0010951,GO:0018149,GO:0019730,GO:0019731,GO:0030280,GO:0031012,GO:0045087,GO:0070268" cornified envelope|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|cytosol|copulation|negative regulation of endopeptidase activity|peptide cross-linking|antimicrobial humoral response|antibacterial humoral response|structural constituent of skin epidermis|extracellular matrix|innate immune response|cornification PI4K2A 3645.381609 3395.027714 3895.735503 1.147482681 0.198472379 0.533045747 1 41.04707013 49.12971361 55361 phosphatidylinositol 4-kinase type 2 alpha "GO:0000287,GO:0004430,GO:0005515,GO:0005524,GO:0005739,GO:0005765,GO:0005768,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0006661,GO:0007030,GO:0007032,GO:0016020,GO:0030425,GO:0031083,GO:0031224,GO:0031410,GO:0035651,GO:0035838,GO:0042734,GO:0043005,GO:0043025,GO:0043204,GO:0045121,GO:0046854" magnesium ion binding|1-phosphatidylinositol 4-kinase activity|protein binding|ATP binding|mitochondrion|lysosomal membrane|endosome|trans-Golgi network|cytosol|plasma membrane|integral component of plasma membrane|phosphatidylinositol biosynthetic process|Golgi organization|endosome organization|membrane|dendrite|BLOC-1 complex|intrinsic component of membrane|cytoplasmic vesicle|AP-3 adaptor complex binding|growing cell tip|presynaptic membrane|neuron projection|neuronal cell body|perikaryon|membrane raft|phosphatidylinositol phosphorylation "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system PI4K2B 599.9500709 567.3603863 632.5397554 1.114881777 0.156890733 0.690697323 1 7.848894302 9.127529118 55300 phosphatidylinositol 4-kinase type 2 beta "GO:0004430,GO:0005524,GO:0005768,GO:0005802,GO:0005829,GO:0005886,GO:0006661,GO:0007030,GO:0007032,GO:0016020,GO:0046854" 1-phosphatidylinositol 4-kinase activity|ATP binding|endosome|trans-Golgi network|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|Golgi organization|endosome organization|membrane|phosphatidylinositol phosphorylation "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system PI4KA 2407.294925 2445.028928 2369.560922 0.969134105 -0.045231781 0.888553368 1 18.04869402 18.24507232 5297 phosphatidylinositol 4-kinase alpha "GO:0004430,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006661,GO:0007165,GO:0016020,GO:0016301,GO:0016310,GO:0019034,GO:0030660,GO:0039694,GO:0044803,GO:0045296,GO:0046786,GO:0046854,GO:0048015,GO:0052742,GO:0070062" 1-phosphatidylinositol 4-kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|focal adhesion|phosphatidylinositol biosynthetic process|signal transduction|membrane|kinase activity|phosphorylation|viral replication complex|Golgi-associated vesicle membrane|viral RNA genome replication|multi-organism membrane organization|cadherin binding|viral replication complex formation and maintenance|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|phosphatidylinositol kinase activity|extracellular exosome "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system PI4KB 1816.448528 1725.425146 1907.47191 1.105508352 0.144709925 0.656668157 1 21.22066458 24.4701673 5298 phosphatidylinositol 4-kinase beta "GO:0000139,GO:0004430,GO:0005515,GO:0005524,GO:0005737,GO:0005741,GO:0005768,GO:0005829,GO:0006661,GO:0006898,GO:0007165,GO:0016020,GO:0016032,GO:0030867,GO:0046854,GO:0048015,GO:0048471,GO:0052742,GO:0071889" Golgi membrane|1-phosphatidylinositol 4-kinase activity|protein binding|ATP binding|cytoplasm|mitochondrial outer membrane|endosome|cytosol|phosphatidylinositol biosynthetic process|receptor-mediated endocytosis|signal transduction|membrane|viral process|rough endoplasmic reticulum membrane|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|phosphatidylinositol kinase activity|14-3-3 protein binding "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system PIANP 331.4575986 297.3820987 365.5330985 1.229169812 0.297684241 0.51818896 1 2.808906042 3.601347489 196500 PILR alpha associated neural protein "GO:0005515,GO:0005886,GO:0016020,GO:0016021,GO:0016323,GO:0050776" protein binding|plasma membrane|membrane|integral component of membrane|basolateral plasma membrane|regulation of immune response PIAS1 735.6208826 715.5439577 755.6978075 1.056116538 0.078769039 0.836163414 1 5.598606082 6.167479077 8554 protein inhibitor of activated STAT 1 "GO:0000082,GO:0000122,GO:0001085,GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007259,GO:0007283,GO:0008022,GO:0008270,GO:0008542,GO:0016605,GO:0016607,GO:0016925,GO:0019789,GO:0019899,GO:0019904,GO:0031625,GO:0032436,GO:0033235,GO:0042127,GO:0043066,GO:0045444,GO:0045893,GO:0051152,GO:0060334,GO:0061665,GO:0065004" "G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|receptor signaling pathway via JAK-STAT|spermatogenesis|protein C-terminus binding|zinc ion binding|visual learning|PML body|nuclear speck|protein sumoylation|SUMO transferase activity|enzyme binding|protein domain specific binding|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein sumoylation|regulation of cell population proliferation|negative regulation of apoptotic process|fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of smooth muscle cell differentiation|regulation of interferon-gamma-mediated signaling pathway|SUMO ligase activity|protein-DNA complex assembly" "hsa04120,hsa04630,hsa05160" Ubiquitin mediated proteolysis|JAK-STAT signaling pathway|Hepatitis C zf-MIZ PIAS2 671.2775746 930.714623 411.8405261 0.442499254 -1.176253073 0.002256656 0.152172743 2.369190405 1.093524298 9063 protein inhibitor of activated STAT 2 "GO:0001085,GO:0003677,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008134,GO:0008270,GO:0016605,GO:0016607,GO:0016925,GO:0019789,GO:0031625,GO:0060766,GO:0061665" RNA polymerase II transcription factor binding|DNA binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|zinc ion binding|PML body|nuclear speck|protein sumoylation|SUMO transferase activity|ubiquitin protein ligase binding|negative regulation of androgen receptor signaling pathway|SUMO ligase activity "hsa04120,hsa04630" Ubiquitin mediated proteolysis|JAK-STAT signaling pathway PIAS3 1182.918557 1051.494383 1314.342732 1.249975989 0.321900382 0.347936563 1 18.35095833 23.92634438 10401 protein inhibitor of activated STAT 3 "GO:0000122,GO:0001085,GO:0003712,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0008022,GO:0008270,GO:0009725,GO:0010628,GO:0015459,GO:0016607,GO:0016925,GO:0019789,GO:0019899,GO:0030425,GO:0033234,GO:0033235,GO:0045202,GO:0045671,GO:0045838,GO:0047485,GO:0061665,GO:0071847" negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|transcription coregulator activity|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|protein C-terminus binding|zinc ion binding|response to hormone|positive regulation of gene expression|potassium channel regulator activity|nuclear speck|protein sumoylation|SUMO transferase activity|enzyme binding|dendrite|negative regulation of protein sumoylation|positive regulation of protein sumoylation|synapse|negative regulation of osteoclast differentiation|positive regulation of membrane potential|protein N-terminus binding|SUMO ligase activity|TNFSF11-mediated signaling pathway "hsa04120,hsa04630" Ubiquitin mediated proteolysis|JAK-STAT signaling pathway PIAS4 387.7606849 374.5187523 401.0026175 1.07071439 0.098573697 0.826720464 1 5.251399109 5.864953801 51588 protein inhibitor of activated STAT 4 "GO:0000122,GO:0001085,GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006303,GO:0006357,GO:0008022,GO:0008270,GO:0010804,GO:0016055,GO:0016363,GO:0016605,GO:0016925,GO:0019789,GO:0031625,GO:0032088,GO:0033235,GO:0042359,GO:0045892,GO:0061665,GO:1902174,GO:1902231,GO:1990234" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|double-strand break repair via nonhomologous end joining|regulation of transcription by RNA polymerase II|protein C-terminus binding|zinc ion binding|negative regulation of tumor necrosis factor-mediated signaling pathway|Wnt signaling pathway|nuclear matrix|PML body|protein sumoylation|SUMO transferase activity|ubiquitin protein ligase binding|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein sumoylation|vitamin D metabolic process|negative regulation of transcription, DNA-templated|SUMO ligase activity|positive regulation of keratinocyte apoptotic process|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|transferase complex" "hsa04064,hsa04120,hsa04630,hsa05418" NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|JAK-STAT signaling pathway|Fluid shear stress and atherosclerosis zf-MIZ PIBF1 198.9922367 199.9463258 198.0381477 0.990456549 -0.01383441 0.99011455 1 3.002246081 3.101684674 10464 progesterone immunomodulatory binding factor 1 "GO:0002376,GO:0005136,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005813,GO:0007080,GO:0031393,GO:0032695,GO:0032733,GO:0032815,GO:0034451,GO:0042531,GO:0042532,GO:0042976,GO:0060271,GO:0071539,GO:0090307,GO:1905515" immune system process|interleukin-4 receptor binding|protein binding|extracellular space|nucleus|cytoplasm|centrosome|mitotic metaphase plate congression|negative regulation of prostaglandin biosynthetic process|negative regulation of interleukin-12 production|positive regulation of interleukin-10 production|negative regulation of natural killer cell activation|centriolar satellite|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|activation of Janus kinase activity|cilium assembly|protein localization to centrosome|mitotic spindle assembly|non-motile cilium assembly PICALM 4184.385579 4073.018301 4295.752856 1.05468538 0.076812698 0.810268025 1 47.50898393 52.26543845 8301 phosphatidylinositol binding clathrin assembly protein "GO:0000149,GO:0001540,GO:0005515,GO:0005545,GO:0005546,GO:0005634,GO:0005769,GO:0005794,GO:0005829,GO:0005886,GO:0005905,GO:0006897,GO:0006898,GO:0006900,GO:0007409,GO:0007611,GO:0008021,GO:0009986,GO:0010629,GO:0016020,GO:0016185,GO:0016188,GO:0016192,GO:0016197,GO:0030097,GO:0030100,GO:0030122,GO:0030132,GO:0030136,GO:0030276,GO:0031224,GO:0031267,GO:0031623,GO:0031982,GO:0032050,GO:0032880,GO:0035459,GO:0042734,GO:0043025,GO:0043231,GO:0043547,GO:0045211,GO:0045296,GO:0045334,GO:0045893,GO:0048156,GO:0048261,GO:0048268,GO:0048471,GO:0048813,GO:0050750,GO:0055072,GO:0061024,GO:0065003,GO:0070381,GO:0072583,GO:0090647,GO:0097418,GO:0097494,GO:0097753,GO:0098894,GO:0150093,GO:1901216,GO:1902003,GO:1902004,GO:1902959,GO:1902961,GO:1902963,GO:1903077,GO:1905224,GO:2000009" "SNARE binding|amyloid-beta binding|protein binding|1-phosphatidylinositol binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|early endosome|Golgi apparatus|cytosol|plasma membrane|clathrin-coated pit|endocytosis|receptor-mediated endocytosis|vesicle budding from membrane|axonogenesis|learning or memory|synaptic vesicle|cell surface|negative regulation of gene expression|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|synaptic vesicle maturation|vesicle-mediated transport|endosomal transport|hemopoiesis|regulation of endocytosis|AP-2 adaptor complex|clathrin coat of coated pit|clathrin-coated vesicle|clathrin binding|intrinsic component of membrane|small GTPase binding|receptor internalization|vesicle|clathrin heavy chain binding|regulation of protein localization|vesicle cargo loading|presynaptic membrane|neuronal cell body|intracellular membrane-bounded organelle|positive regulation of GTPase activity|postsynaptic membrane|cadherin binding|clathrin-coated endocytic vesicle|positive regulation of transcription, DNA-templated|tau protein binding|negative regulation of receptor-mediated endocytosis|clathrin coat assembly|perinuclear region of cytoplasm|dendrite morphogenesis|low-density lipoprotein particle receptor binding|iron ion homeostasis|membrane organization|protein-containing complex assembly|endosome to plasma membrane transport vesicle|clathrin-dependent endocytosis|modulation of age-related behavioral decline|neurofibrillary tangle|regulation of vesicle size|membrane bending|extrinsic component of presynaptic endocytic zone membrane|amyloid-beta clearance by transcytosis|positive regulation of neuron death|regulation of amyloid-beta formation|positive regulation of amyloid-beta formation|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of protein localization to plasma membrane|clathrin-coated pit assembly|negative regulation of protein localization to cell surface" PICK1 586.5532456 459.7750537 713.3314376 1.551479211 0.633644366 0.10734368 1 8.216649428 13.29709122 9463 protein interacting with PRKCA 1 "GO:0001664,GO:0002092,GO:0005080,GO:0005102,GO:0005515,GO:0005543,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0006886,GO:0006890,GO:0007205,GO:0008021,GO:0008022,GO:0014069,GO:0015844,GO:0019899,GO:0019904,GO:0021782,GO:0030666,GO:0032588,GO:0034315,GO:0034316,GO:0036294,GO:0042149,GO:0042734,GO:0042802,GO:0043005,GO:0043045,GO:0043046,GO:0043113,GO:0045161,GO:0045202,GO:0046872,GO:0048471,GO:0050796,GO:0051015,GO:0060292,GO:0071933,GO:0097061,GO:0097062,GO:0098842,GO:0140090" "G protein-coupled receptor binding|positive regulation of receptor internalization|protein kinase C binding|signaling receptor binding|protein binding|phospholipid binding|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein kinase C-activating G protein-coupled receptor signaling pathway|synaptic vesicle|protein C-terminus binding|postsynaptic density|monoamine transport|enzyme binding|protein domain specific binding|glial cell development|endocytic vesicle membrane|trans-Golgi network membrane|regulation of Arp2/3 complex-mediated actin nucleation|negative regulation of Arp2/3 complex-mediated actin nucleation|cellular response to decreased oxygen levels|cellular response to glucose starvation|presynaptic membrane|identical protein binding|neuron projection|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|receptor clustering|neuronal ion channel clustering|synapse|metal ion binding|perinuclear region of cytoplasm|regulation of insulin secretion|actin filament binding|long-term synaptic depression|Arp2/3 complex binding|dendritic spine organization|dendritic spine maintenance|postsynaptic early endosome|membrane curvature sensor activity" PID1 348.1543916 394.8178717 301.4909115 0.763620224 -0.389072784 0.389883292 1 2.408882348 1.918708239 55022 phosphotyrosine interaction domain containing 1 "GO:0001933,GO:0005515,GO:0005737,GO:0006112,GO:0010628,GO:0010635,GO:0044320,GO:0045444,GO:0045944,GO:0046325,GO:0046627,GO:0051881,GO:0070346,GO:0070584,GO:0071345,GO:0071354,GO:0071356,GO:0071398,GO:1903077,GO:2000377,GO:2000379,GO:2001170,GO:2001171" negative regulation of protein phosphorylation|protein binding|cytoplasm|energy reserve metabolic process|positive regulation of gene expression|regulation of mitochondrial fusion|cellular response to leptin stimulus|fat cell differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|regulation of mitochondrial membrane potential|positive regulation of fat cell proliferation|mitochondrion morphogenesis|cellular response to cytokine stimulus|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to fatty acid|negative regulation of protein localization to plasma membrane|regulation of reactive oxygen species metabolic process|positive regulation of reactive oxygen species metabolic process|negative regulation of ATP biosynthetic process|positive regulation of ATP biosynthetic process PIDD1 388.4275071 251.7090802 525.145934 2.086320977 1.060961131 0.015993981 0.5587138 2.91653556 6.346939089 55367 p53-induced death domain protein 1 "GO:0004175,GO:0005123,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006915,GO:0006919,GO:0006974,GO:0006977,GO:0007165,GO:0008625,GO:0016540,GO:0042981,GO:0043065,GO:0043066,GO:0043122,GO:0051092" "endopeptidase activity|death receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|signal transduction|extrinsic apoptotic signaling pathway via death domain receptors|protein autoprocessing|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of NF-kappaB transcription factor activity" "hsa04064,hsa04115,hsa04210" NF-kappa B signaling pathway|p53 signaling pathway|Apoptosis PIEZO1 6172.640268 5284.875727 7060.404809 1.335964207 0.417881356 0.198840001 1 33.08941917 46.11050688 9780 piezo type mechanosensitive ion channel component 1 "GO:0005261,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006812,GO:0008381,GO:0016020,GO:0016021,GO:0031258,GO:0033116,GO:0033625,GO:0033634,GO:0042391,GO:0050982,GO:0071260,GO:0098655" cation channel activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cation transport|mechanosensitive ion channel activity|membrane|integral component of membrane|lamellipodium membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|positive regulation of integrin activation|positive regulation of cell-cell adhesion mediated by integrin|regulation of membrane potential|detection of mechanical stimulus|cellular response to mechanical stimulus|cation transmembrane transport PIEZO2 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.014114206 0.004763835 63895 piezo type mechanosensitive ion channel component 2 "GO:0005261,GO:0005886,GO:0006812,GO:0008381,GO:0009612,GO:0016020,GO:0016021,GO:0042391,GO:0050974,GO:0050982,GO:0071260,GO:0098655" cation channel activity|plasma membrane|cation transport|mechanosensitive ion channel activity|response to mechanical stimulus|membrane|integral component of membrane|regulation of membrane potential|detection of mechanical stimulus involved in sensory perception|detection of mechanical stimulus|cellular response to mechanical stimulus|cation transmembrane transport PIF1 343.3131848 265.9184637 420.7079059 1.582093624 0.661834977 0.144953683 1 4.634491426 7.648040744 80119 PIF1 5'-to-3' DNA helicase "GO:0000002,GO:0000287,GO:0000723,GO:0000781,GO:0005524,GO:0005634,GO:0005657,GO:0005739,GO:0006260,GO:0006281,GO:0006310,GO:0010521,GO:0017116,GO:0032204,GO:0032211,GO:0032508,GO:0033678,GO:0042162,GO:0043139,GO:0051880,GO:0051974" "mitochondrial genome maintenance|magnesium ion binding|telomere maintenance|chromosome, telomeric region|ATP binding|nucleus|replication fork|mitochondrion|DNA replication|DNA repair|DNA recombination|telomerase inhibitor activity|single-stranded DNA helicase activity|regulation of telomere maintenance|negative regulation of telomere maintenance via telomerase|DNA duplex unwinding|5'-3' DNA/RNA helicase activity|telomeric DNA binding|5'-3' DNA helicase activity|G-quadruplex DNA binding|negative regulation of telomerase activity" PIFO 4.985705186 4.059823873 5.911586499 1.456118956 0.542128219 0.871693704 1 0.079819781 0.121233689 128344 primary cilia formation "GO:0005515,GO:0005634,GO:0005802,GO:0008092,GO:0019894,GO:0019901,GO:0031267,GO:0031344,GO:0031410,GO:0033674,GO:0036064,GO:0043015,GO:0044782,GO:0048487,GO:0060971" protein binding|nucleus|trans-Golgi network|cytoskeletal protein binding|kinesin binding|protein kinase binding|small GTPase binding|regulation of cell projection organization|cytoplasmic vesicle|positive regulation of kinase activity|ciliary basal body|gamma-tubulin binding|cilium organization|beta-tubulin binding|embryonic heart tube left/right pattern formation PIGA 539.2254189 524.7322356 553.7186021 1.055240301 0.077571569 0.850707318 1 5.062064113 5.571792572 5277 phosphatidylinositol glycan anchor biosynthesis class A "GO:0000506,GO:0005515,GO:0005789,GO:0006506,GO:0008194,GO:0009893,GO:0016020,GO:0016021,GO:0016254,GO:0017176,GO:1990830" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|UDP-glycosyltransferase activity|positive regulation of metabolic process|membrane|integral component of membrane|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity|cellular response to leukemia inhibitory factor hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGB 230.6246185 207.0510175 254.1982195 1.227708139 0.295967632 0.568518441 1 4.353011045 5.574434718 9488 phosphatidylinositol glycan anchor biosynthesis class B "GO:0000026,GO:0000030,GO:0004376,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0097502" "alpha-1,2-mannosyltransferase activity|mannosyltransferase activity|glycolipid mannosyltransferase activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|mannosylation" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGBOS1 130.254579 114.6900244 145.8191336 1.271419501 0.346440122 0.581976024 1 4.341289339 5.757361905 101928527 PIGB opposite strand 1 "GO:0005515,GO:0006986,GO:0031307,GO:1900101" protein binding|response to unfolded protein|integral component of mitochondrial outer membrane|regulation of endoplasmic reticulum unfolded protein response PIGC 539.6411006 553.1510028 526.1311984 0.951152933 -0.072250769 0.861161608 1 18.94195192 18.79277919 5279 phosphatidylinositol glycan anchor biosynthesis class C "GO:0000506,GO:0003824,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0017176" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|catalytic activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGF 258.5507534 263.8885518 253.2129551 0.959545055 -0.059577545 0.91215225 1 9.000016299 9.007921598 5281 phosphatidylinositol glycan anchor biosynthesis class F "GO:0004307,GO:0005515,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0051377" ethanolaminephosphotransferase activity|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|mannose-ethanolamine phosphotransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGG 782.1307078 796.7404352 767.5209805 0.963326256 -0.053903607 0.887139375 1 7.915278994 7.953449986 54872 phosphatidylinositol glycan anchor biosynthesis class G "GO:0005783,GO:0005789,GO:0006506,GO:0016020,GO:0016254,GO:0016780,GO:0030176,GO:0051267" "endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|membrane|preassembly of GPI anchor in ER membrane|phosphotransferase activity, for other substituted phosphate groups|integral component of endoplasmic reticulum membrane|CP2 mannose-ethanolamine phosphotransferase activity" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGH 358.6211558 369.4439725 347.798339 0.941410241 -0.087104548 0.851247841 1 12.24544103 12.02456236 5283 phosphatidylinositol glycan anchor biosynthesis class H "GO:0000506,GO:0003824,GO:0005783,GO:0005789,GO:0006464,GO:0006506,GO:0016254,GO:0017176" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|catalytic activity|endoplasmic reticulum|endoplasmic reticulum membrane|cellular protein modification process|GPI anchor biosynthetic process|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGK 1353.540524 1332.637186 1374.443861 1.031371385 0.044563925 0.896591954 1 14.66928325 15.78119558 10026 phosphatidylinositol glycan anchor biosynthesis class K "GO:0003756,GO:0003923,GO:0005515,GO:0005789,GO:0006508,GO:0016020,GO:0016255,GO:0018215,GO:0034235,GO:0034394,GO:0042765" protein disulfide isomerase activity|GPI-anchor transamidase activity|protein binding|endoplasmic reticulum membrane|proteolysis|membrane|attachment of GPI anchor to protein|protein phosphopantetheinylation|GPI anchor binding|protein localization to cell surface|GPI-anchor transamidase complex hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGL 244.0296086 214.1557093 273.9035078 1.278992321 0.355007603 0.484463185 1 1.559711128 2.080788972 9487 phosphatidylinositol glycan anchor biosynthesis class L "GO:0000225,GO:0005783,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0016811" "N-acetylglucosaminylphosphatidylinositol deacetylase activity|endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGM 450.7567406 572.4351662 329.0783151 0.574874387 -0.798681341 0.057641749 1 4.11932676 2.470103393 93183 phosphatidylinositol glycan anchor biosynthesis class M "GO:0000030,GO:0004376,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0051751,GO:0097502,GO:1990529" "mannosyltransferase activity|glycolipid mannosyltransferase activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|alpha-1,4-mannosyltransferase activity|mannosylation|glycosylphosphatidylinositol-mannosyltransferase I complex" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGN 1003.009324 977.4025975 1028.616051 1.052397501 0.073679727 0.836674344 1 6.153137787 6.754487124 23556 phosphatidylinositol glycan anchor biosynthesis class N "GO:0005789,GO:0005829,GO:0005886,GO:0006506,GO:0016020,GO:0016021,GO:0016254,GO:0051377" endoplasmic reticulum membrane|cytosol|plasma membrane|GPI anchor biosynthetic process|membrane|integral component of membrane|preassembly of GPI anchor in ER membrane|mannose-ethanolamine phosphotransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGO 1249.028267 1327.562407 1170.494127 0.881686707 -0.181661986 0.593978906 1 10.62353492 9.770105938 84720 phosphatidylinositol glycan anchor biosynthesis class O "GO:0005789,GO:0006506,GO:0016020,GO:0016021,GO:0051377" endoplasmic reticulum membrane|GPI anchor biosynthetic process|membrane|integral component of membrane|mannose-ethanolamine phosphotransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGP 278.7311066 296.3671428 261.0950704 0.880985213 -0.182810291 0.710331729 1 15.25401449 14.01743992 51227 phosphatidylinositol glycan anchor biosynthesis class P "GO:0000506,GO:0005515,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0017176" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGQ 779.2194519 799.7853031 758.6536007 0.94857157 -0.076171465 0.839559821 1 13.69381478 13.5491011 9091 phosphatidylinositol glycan anchor biosynthesis class Q "GO:0000506,GO:0005789,GO:0005975,GO:0006506,GO:0016021,GO:0016254,GO:0017176" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane|carbohydrate metabolic process|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGS 1511.221678 1773.128077 1249.31528 0.704582651 -0.505159144 0.127537263 1 35.50916642 26.09686579 94005 phosphatidylinositol glycan anchor biosynthesis class S "GO:0005515,GO:0005789,GO:0016020,GO:0016255,GO:0042765" protein binding|endoplasmic reticulum membrane|membrane|attachment of GPI anchor to protein|GPI-anchor transamidase complex hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGT 6543.635628 7140.215238 5947.056018 0.832895903 -0.263791899 0.418664633 1 169.9373649 147.63711 51604 phosphatidylinositol glycan anchor biosynthesis class T "GO:0005515,GO:0005789,GO:0016020,GO:0016255,GO:0030176,GO:0042765" protein binding|endoplasmic reticulum membrane|membrane|attachment of GPI anchor to protein|integral component of endoplasmic reticulum membrane|GPI-anchor transamidase complex hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGU 820.1754731 703.3644861 936.9864601 1.332149232 0.413755707 0.257876834 1 13.12078449 18.23176066 128869 phosphatidylinositol glycan anchor biosynthesis class U "GO:0005515,GO:0005789,GO:0005886,GO:0006506,GO:0016020,GO:0016255,GO:0034235,GO:0034394,GO:0042765,GO:0046425" protein binding|endoplasmic reticulum membrane|plasma membrane|GPI anchor biosynthetic process|membrane|attachment of GPI anchor to protein|GPI anchor binding|protein localization to cell surface|GPI-anchor transamidase complex|regulation of receptor signaling pathway via JAK-STAT hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGV 358.8047483 314.6363502 402.9731464 1.280758393 0.356998346 0.426295949 1 3.051555183 4.076658839 55650 phosphatidylinositol glycan anchor biosynthesis class V "GO:0000009,GO:0000030,GO:0004376,GO:0005515,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0031501,GO:0097502" "alpha-1,6-mannosyltransferase activity|mannosyltransferase activity|glycolipid mannosyltransferase activity|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|mannosyltransferase complex|mannosylation" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGW 272.0272507 309.5615704 234.4929311 0.757500134 -0.40068195 0.412709279 1 6.882441383 5.438024566 284098 phosphatidylinositol glycan anchor biosynthesis class W "GO:0005789,GO:0006505,GO:0006506,GO:0008374,GO:0016021,GO:0016254,GO:0032216,GO:0072659" endoplasmic reticulum membrane|GPI anchor metabolic process|GPI anchor biosynthetic process|O-acyltransferase activity|integral component of membrane|preassembly of GPI anchor in ER membrane|glucosaminyl-phosphatidylinositol O-acyltransferase activity|protein localization to plasma membrane hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGX 371.6550014 351.1747651 392.1352378 1.116638429 0.159162112 0.723335934 1 5.752187251 6.699795005 54965 phosphatidylinositol glycan anchor biosynthesis class X "GO:0005789,GO:0016021,GO:0016254" endoplasmic reticulum membrane|integral component of membrane|preassembly of GPI anchor in ER membrane hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGZ 144.2115844 125.8545401 162.5686287 1.291718429 0.369291623 0.54247403 1 1.106996955 1.491523882 80235 phosphatidylinositol glycan anchor biosynthesis class Z "GO:0000026,GO:0000030,GO:0005783,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0097502" "alpha-1,2-mannosyltransferase activity|mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|mannosylation" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIH1D1 831.4978491 803.845127 859.1505712 1.068801119 0.095993423 0.794847672 1 34.1829722 38.1085699 55011 PIH1 domain containing 1 "GO:0000492,GO:0001164,GO:0001165,GO:0001188,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0006338,GO:0006364,GO:0019901,GO:0030855,GO:0031334,GO:0042393,GO:0048254,GO:0051117,GO:0051219,GO:0051569,GO:0070761,GO:0071169,GO:0071902,GO:0090240,GO:0097255,GO:1900110,GO:1900113,GO:1901838,GO:1902661,GO:1903939,GO:1904263,GO:1990904,GO:2000617,GO:2000619,GO:2001268" box C/D snoRNP assembly|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I cis-regulatory region sequence-specific DNA binding|RNA polymerase I preinitiation complex assembly|protein binding|nucleus|nucleolus|cytoplasm|chromatin remodeling|rRNA processing|protein kinase binding|epithelial cell differentiation|positive regulation of protein-containing complex assembly|histone binding|snoRNA localization|ATPase binding|phosphoprotein binding|regulation of histone H3-K4 methylation|pre-snoRNP complex|establishment of protein localization to chromatin|positive regulation of protein serine/threonine kinase activity|positive regulation of histone H4 acetylation|R2TP complex|negative regulation of histone H3-K9 dimethylation|negative regulation of histone H3-K9 trimethylation|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|positive regulation of glucose mediated signaling pathway|regulation of TORC2 signaling|positive regulation of TORC1 signaling|ribonucleoprotein complex|positive regulation of histone H3-K9 acetylation|negative regulation of histone H4-K16 acetylation|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway PIH1D2 33.67441787 45.67301858 21.67581716 0.474586919 -1.075255759 0.262882453 1 0.566261265 0.280316426 120379 PIH1 domain containing 2 "GO:0000492,GO:0005515,GO:0005737,GO:0006364,GO:0031267,GO:0097255,GO:1990904" box C/D snoRNP assembly|protein binding|cytoplasm|rRNA processing|small GTPase binding|R2TP complex|ribonucleoprotein complex PIK3AP1 172.1646893 218.2155332 126.1138453 0.577932485 -0.791027131 0.162896201 1 2.215242922 1.335409291 118788 phosphoinositide-3-kinase adaptor protein 1 "GO:0005102,GO:0005515,GO:0005829,GO:0005886,GO:0014068,GO:0016020,GO:0034134,GO:0034142,GO:0034154,GO:0034162,GO:0036312,GO:0042802,GO:0050727,GO:0051897" signaling receptor binding|protein binding|cytosol|plasma membrane|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway|phosphatidylinositol 3-kinase regulatory subunit binding|identical protein binding|regulation of inflammatory response|positive regulation of protein kinase B signaling "hsa04151,hsa04662" PI3K-Akt signaling pathway|B cell receptor signaling pathway PIK3C2A 1722.405757 1661.48292 1783.328594 1.073335496 0.102101094 0.755593983 1 9.874237098 11.05490393 5286 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha "GO:0005524,GO:0005654,GO:0005737,GO:0005802,GO:0005829,GO:0005886,GO:0005942,GO:0006661,GO:0006887,GO:0006897,GO:0007173,GO:0008286,GO:0010508,GO:0014065,GO:0014829,GO:0016020,GO:0016303,GO:0016477,GO:0030136,GO:0030276,GO:0031982,GO:0035004,GO:0035005,GO:0035091,GO:0036092,GO:0043231,GO:0046854,GO:0046934,GO:0048008,GO:0048015,GO:0048268,GO:0052742,GO:0052812,GO:0061024,GO:0070062,GO:0090050" "ATP binding|nucleoplasm|cytoplasm|trans-Golgi network|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|exocytosis|endocytosis|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of autophagy|phosphatidylinositol 3-kinase signaling|vascular associated smooth muscle contraction|membrane|1-phosphatidylinositol-3-kinase activity|cell migration|clathrin-coated vesicle|clathrin binding|vesicle|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|phosphatidylinositol binding|phosphatidylinositol-3-phosphate biosynthetic process|intracellular membrane-bounded organelle|phosphatidylinositol phosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|platelet-derived growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|clathrin coat assembly|phosphatidylinositol kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|membrane organization|extracellular exosome|positive regulation of cell migration involved in sprouting angiogenesis" "hsa00562,hsa04070,hsa05132" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Salmonella infection PIK3C2B 260.66974 274.0381115 247.3013686 0.902434217 -0.148106324 0.770313332 1 1.446489171 1.361590994 5287 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta "GO:0001727,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0005942,GO:0006661,GO:0008150,GO:0009267,GO:0014065,GO:0016020,GO:0016303,GO:0016477,GO:0030139,GO:0035005,GO:0035091,GO:0036092,GO:0043231,GO:0043491,GO:0046854,GO:0048015,GO:0052742,GO:1905037" lipid kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|biological_process|cellular response to starvation|phosphatidylinositol 3-kinase signaling|membrane|1-phosphatidylinositol-3-kinase activity|cell migration|endocytic vesicle|1-phosphatidylinositol-4-phosphate 3-kinase activity|phosphatidylinositol binding|phosphatidylinositol-3-phosphate biosynthetic process|intracellular membrane-bounded organelle|protein kinase B signaling|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|phosphatidylinositol kinase activity|autophagosome organization "hsa00562,hsa04070,hsa05132" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Salmonella infection PIK3C3 1099.876998 998.7166729 1201.037324 1.202580628 0.266133624 0.443298902 1 9.831190713 12.33207776 5289 phosphatidylinositol 3-kinase catalytic subunit type 3 "GO:0000045,GO:0000407,GO:0005515,GO:0005524,GO:0005737,GO:0005768,GO:0005770,GO:0005777,GO:0005829,GO:0005930,GO:0006497,GO:0006661,GO:0006897,GO:0006914,GO:0007049,GO:0016020,GO:0016236,GO:0016301,GO:0016303,GO:0030242,GO:0030496,GO:0030670,GO:0032465,GO:0034162,GO:0034271,GO:0034272,GO:0035032,GO:0036092,GO:0042149,GO:0044754,GO:0045022,GO:0046854,GO:0048015,GO:0051301,GO:0052742" "autophagosome assembly|phagophore assembly site|protein binding|ATP binding|cytoplasm|endosome|late endosome|peroxisome|cytosol|axoneme|protein lipidation|phosphatidylinositol biosynthetic process|endocytosis|autophagy|cell cycle|membrane|macroautophagy|kinase activity|1-phosphatidylinositol-3-kinase activity|autophagy of peroxisome|midbody|phagocytic vesicle membrane|regulation of cytokinesis|toll-like receptor 9 signaling pathway|phosphatidylinositol 3-kinase complex, class III, type I|phosphatidylinositol 3-kinase complex, class III, type II|phosphatidylinositol 3-kinase complex, class III|phosphatidylinositol-3-phosphate biosynthetic process|cellular response to glucose starvation|autolysosome|early endosome to late endosome transport|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|cell division|phosphatidylinositol kinase activity" "hsa00562,hsa04070,hsa04136,hsa04140,hsa04145,hsa04371,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131,hsa05132,hsa05152,hsa05167" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - other|Autophagy - animal|Phagosome|Apelin signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Salmonella infection|Tuberculosis|Kaposi sarcoma-associated herpesvirus infection PIK3CA 918.2874708 843.4284097 993.1465319 1.177511358 0.235740975 0.510771502 1 9.294315386 11.41559204 5290 "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha" "GO:0001525,GO:0001889,GO:0001944,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0005943,GO:0005944,GO:0006006,GO:0006468,GO:0006661,GO:0007173,GO:0007186,GO:0007411,GO:0010468,GO:0010592,GO:0014065,GO:0014068,GO:0014704,GO:0016020,GO:0016242,GO:0016301,GO:0016303,GO:0016310,GO:0016477,GO:0019221,GO:0030027,GO:0030036,GO:0030168,GO:0030295,GO:0030835,GO:0031295,GO:0032008,GO:0032147,GO:0033138,GO:0035004,GO:0035005,GO:0035994,GO:0036092,GO:0038028,GO:0038084,GO:0038095,GO:0038096,GO:0038128,GO:0040014,GO:0043276,GO:0043457,GO:0043491,GO:0043524,GO:0043542,GO:0043560,GO:0044029,GO:0046854,GO:0046934,GO:0048010,GO:0048015,GO:0048471,GO:0050852,GO:0050900,GO:0051897,GO:0052742,GO:0052812,GO:0055119,GO:0060048,GO:0060612,GO:0071333,GO:0071464,GO:0086003,GO:0097009,GO:0106310,GO:0106311,GO:0110053,GO:2000270,GO:2000653,GO:2000811" "angiogenesis|liver development|vasculature development|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol 3-kinase complex, class IA|phosphatidylinositol 3-kinase complex, class IB|glucose metabolic process|protein phosphorylation|phosphatidylinositol biosynthetic process|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|axon guidance|regulation of gene expression|positive regulation of lamellipodium assembly|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|intercalated disc|membrane|negative regulation of macroautophagy|kinase activity|1-phosphatidylinositol-3-kinase activity|phosphorylation|cell migration|cytokine-mediated signaling pathway|lamellipodium|actin cytoskeleton organization|platelet activation|protein kinase activator activity|negative regulation of actin filament depolymerization|T cell costimulation|positive regulation of TOR signaling|activation of protein kinase activity|positive regulation of peptidyl-serine phosphorylation|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|response to muscle stretch|phosphatidylinositol-3-phosphate biosynthetic process|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|vascular endothelial growth factor signaling pathway|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|regulation of multicellular organism growth|anoikis|regulation of cellular respiration|protein kinase B signaling|negative regulation of neuron apoptotic process|endothelial cell migration|insulin receptor substrate binding|hypomethylation of CpG island|phosphatidylinositol phosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|T cell receptor signaling pathway|leukocyte migration|positive regulation of protein kinase B signaling|phosphatidylinositol kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|relaxation of cardiac muscle|cardiac muscle contraction|adipose tissue development|cellular response to glucose stimulus|cellular response to hydrostatic pressure|cardiac muscle cell contraction|energy homeostasis|protein serine kinase activity|protein threonine kinase activity|regulation of actin filament organization|negative regulation of fibroblast apoptotic process|regulation of genetic imprinting|negative regulation of anoikis" "hsa00562,hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05132,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3CB 714.3904387 745.9926368 682.7882407 0.915274772 -0.127723179 0.736578023 1 6.072307192 5.79723834 5291 "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta" "GO:0000187,GO:0001952,GO:0002931,GO:0003376,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0006661,GO:0006897,GO:0006914,GO:0006935,GO:0007165,GO:0007169,GO:0007186,GO:0007411,GO:0010508,GO:0010595,GO:0010628,GO:0014065,GO:0014068,GO:0016020,GO:0016301,GO:0016303,GO:0016310,GO:0016477,GO:0019221,GO:0030168,GO:0030496,GO:0033031,GO:0035004,GO:0035005,GO:0035022,GO:0036092,GO:0038095,GO:0038096,GO:0043231,GO:0043407,GO:0046854,GO:0046934,GO:0048010,GO:0048015,GO:0050852,GO:0050900,GO:0051000,GO:0051897,GO:0051898,GO:0052742,GO:0052812,GO:0070527,GO:1900747,GO:1903671,GO:2000369" "activation of MAPK activity|regulation of cell-matrix adhesion|response to ischemia|sphingosine-1-phosphate receptor signaling pathway|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|endocytosis|autophagy|chemotaxis|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|G protein-coupled receptor signaling pathway|axon guidance|positive regulation of autophagy|positive regulation of endothelial cell migration|positive regulation of gene expression|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|kinase activity|1-phosphatidylinositol-3-kinase activity|phosphorylation|cell migration|cytokine-mediated signaling pathway|platelet activation|midbody|positive regulation of neutrophil apoptotic process|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|positive regulation of Rac protein signal transduction|phosphatidylinositol-3-phosphate biosynthetic process|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|intracellular membrane-bounded organelle|negative regulation of MAP kinase activity|phosphatidylinositol phosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|T cell receptor signaling pathway|leukocyte migration|positive regulation of nitric-oxide synthase activity|positive regulation of protein kinase B signaling|negative regulation of protein kinase B signaling|phosphatidylinositol kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|platelet aggregation|negative regulation of vascular endothelial growth factor signaling pathway|negative regulation of sprouting angiogenesis|regulation of clathrin-dependent endocytosis" "hsa00562,hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05132,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3CD 3719.616409 3620.347939 3818.884879 1.054839187 0.077023074 0.809403598 1 29.88230953 32.87882929 5293 "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta" "GO:0001779,GO:0001816,GO:0001938,GO:0002250,GO:0002551,GO:0002679,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0006468,GO:0006661,GO:0006954,GO:0007165,GO:0007411,GO:0010595,GO:0010628,GO:0010818,GO:0014065,GO:0014068,GO:0016020,GO:0016301,GO:0016303,GO:0016310,GO:0016477,GO:0019221,GO:0030101,GO:0030217,GO:0030335,GO:0030593,GO:0033031,GO:0035004,GO:0035005,GO:0035747,GO:0035754,GO:0036092,GO:0038089,GO:0042110,GO:0042113,GO:0043303,GO:0045087,GO:0045766,GO:0046854,GO:0046934,GO:0048015,GO:0050852,GO:0050853,GO:0051897,GO:0052742,GO:0052812,GO:0060374,GO:0072672,GO:1905278" "natural killer cell differentiation|cytokine production|positive regulation of endothelial cell proliferation|adaptive immune response|mast cell chemotaxis|respiratory burst involved in defense response|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|protein phosphorylation|phosphatidylinositol biosynthetic process|inflammatory response|signal transduction|axon guidance|positive regulation of endothelial cell migration|positive regulation of gene expression|T cell chemotaxis|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|kinase activity|1-phosphatidylinositol-3-kinase activity|phosphorylation|cell migration|cytokine-mediated signaling pathway|natural killer cell activation|T cell differentiation|positive regulation of cell migration|neutrophil chemotaxis|positive regulation of neutrophil apoptotic process|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|natural killer cell chemotaxis|B cell chemotaxis|phosphatidylinositol-3-phosphate biosynthetic process|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|T cell activation|B cell activation|mast cell degranulation|innate immune response|positive regulation of angiogenesis|phosphatidylinositol phosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|phosphatidylinositol-mediated signaling|T cell receptor signaling pathway|B cell receptor signaling pathway|positive regulation of protein kinase B signaling|phosphatidylinositol kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|mast cell differentiation|neutrophil extravasation|positive regulation of epithelial tube formation" "hsa00562,hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05132,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3CG 48.18343855 60.8973581 35.469519 0.582447582 -0.779799875 0.366745144 1 0.381005109 0.231474724 5294 "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma" "GO:0001525,GO:0001816,GO:0002250,GO:0002407,GO:0002675,GO:0002679,GO:0003376,GO:0004672,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0005943,GO:0005944,GO:0006468,GO:0006661,GO:0006897,GO:0006954,GO:0007186,GO:0007204,GO:0010595,GO:0010818,GO:0010897,GO:0014065,GO:0014068,GO:0016020,GO:0016301,GO:0016303,GO:0016310,GO:0016477,GO:0030168,GO:0030593,GO:0032252,GO:0033628,GO:0035004,GO:0035005,GO:0035022,GO:0035747,GO:0036092,GO:0042098,GO:0042110,GO:0042802,GO:0043303,GO:0043406,GO:0045087,GO:0046854,GO:0046875,GO:0046934,GO:0048015,GO:0051897,GO:0052742,GO:0052812,GO:0055118,GO:0070527,GO:0071320,GO:0072672,GO:0097284,GO:0106310,GO:0106311,GO:1903169,GO:2000270" "angiogenesis|cytokine production|adaptive immune response|dendritic cell chemotaxis|positive regulation of acute inflammatory response|respiratory burst involved in defense response|sphingosine-1-phosphate receptor signaling pathway|protein kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol 3-kinase complex, class IA|phosphatidylinositol 3-kinase complex, class IB|protein phosphorylation|phosphatidylinositol biosynthetic process|endocytosis|inflammatory response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|positive regulation of endothelial cell migration|T cell chemotaxis|negative regulation of triglyceride catabolic process|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|kinase activity|1-phosphatidylinositol-3-kinase activity|phosphorylation|cell migration|platelet activation|neutrophil chemotaxis|secretory granule localization|regulation of cell adhesion mediated by integrin|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|positive regulation of Rac protein signal transduction|natural killer cell chemotaxis|phosphatidylinositol-3-phosphate biosynthetic process|T cell proliferation|T cell activation|identical protein binding|mast cell degranulation|positive regulation of MAP kinase activity|innate immune response|phosphatidylinositol phosphorylation|ephrin receptor binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase B signaling|phosphatidylinositol kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|negative regulation of cardiac muscle contraction|platelet aggregation|cellular response to cAMP|neutrophil extravasation|hepatocyte apoptotic process|protein serine kinase activity|protein threonine kinase activity|regulation of calcium ion transmembrane transport|negative regulation of fibroblast apoptotic process" "hsa00562,hsa04022,hsa04062,hsa04072,hsa04151,hsa04261,hsa04371,hsa04611,hsa04725,hsa04921,hsa05132,hsa05145,hsa05167" Inositol phosphate metabolism|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Platelet activation|Cholinergic synapse|Oxytocin signaling pathway|Salmonella infection|Toxoplasmosis|Kaposi sarcoma-associated herpesvirus infection PIK3IP1 194.3034471 216.1856213 172.4212729 0.797561243 -0.32633279 0.55206766 1 4.511346955 3.753065986 113791 phosphoinositide-3-kinase interacting protein 1 "GO:0004252,GO:0005515,GO:0005886,GO:0006508,GO:0014067,GO:0016021,GO:0036313,GO:0043553" serine-type endopeptidase activity|protein binding|plasma membrane|proteolysis|negative regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|phosphatidylinositol 3-kinase catalytic subunit binding|negative regulation of phosphatidylinositol 3-kinase activity PIK3R1 739.3729045 837.3386739 641.4071352 0.76600682 -0.384570857 0.303167126 1 4.400565516 3.516066315 5295 phosphoinositide-3-kinase regulatory subunit 1 "GO:0001678,GO:0001784,GO:0001953,GO:0005068,GO:0005158,GO:0005159,GO:0005168,GO:0005515,GO:0005634,GO:0005737,GO:0005801,GO:0005829,GO:0005886,GO:0005911,GO:0005942,GO:0005943,GO:0006468,GO:0006606,GO:0006661,GO:0007173,GO:0007186,GO:0007411,GO:0008134,GO:0008286,GO:0008625,GO:0008630,GO:0010592,GO:0014065,GO:0014068,GO:0016020,GO:0016032,GO:0019221,GO:0019903,GO:0030168,GO:0030183,GO:0030335,GO:0031295,GO:0032760,GO:0032869,GO:0033120,GO:0034446,GO:0034644,GO:0034976,GO:0035014,GO:0036312,GO:0038095,GO:0038096,GO:0038128,GO:0042307,GO:0043066,GO:0043125,GO:0043548,GO:0043551,GO:0043559,GO:0043560,GO:0045671,GO:0045944,GO:0046326,GO:0046626,GO:0046854,GO:0046935,GO:0046982,GO:0048009,GO:0048010,GO:0048015,GO:0048471,GO:0050821,GO:0050852,GO:0050900,GO:0051491,GO:0051497,GO:0051897,GO:0060396,GO:0120183,GO:1900103,GO:1903078,GO:1990578" "cellular glucose homeostasis|phosphotyrosine residue binding|negative regulation of cell-matrix adhesion|transmembrane receptor protein tyrosine kinase adaptor activity|insulin receptor binding|insulin-like growth factor receptor binding|neurotrophin TRKA receptor binding|protein binding|nucleus|cytoplasm|cis-Golgi network|cytosol|plasma membrane|cell-cell junction|phosphatidylinositol 3-kinase complex|phosphatidylinositol 3-kinase complex, class IA|protein phosphorylation|protein import into nucleus|phosphatidylinositol biosynthetic process|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|axon guidance|transcription factor binding|insulin receptor signaling pathway|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of lamellipodium assembly|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|viral process|cytokine-mediated signaling pathway|protein phosphatase binding|platelet activation|B cell differentiation|positive regulation of cell migration|T cell costimulation|positive regulation of tumor necrosis factor production|cellular response to insulin stimulus|positive regulation of RNA splicing|substrate adhesion-dependent cell spreading|cellular response to UV|response to endoplasmic reticulum stress|phosphatidylinositol 3-kinase regulator activity|phosphatidylinositol 3-kinase regulatory subunit binding|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|positive regulation of protein import into nucleus|negative regulation of apoptotic process|ErbB-3 class receptor binding|phosphatidylinositol 3-kinase binding|regulation of phosphatidylinositol 3-kinase activity|insulin binding|insulin receptor substrate binding|negative regulation of osteoclast differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|protein heterodimerization activity|insulin-like growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|protein stabilization|T cell receptor signaling pathway|leukocyte migration|positive regulation of filopodium assembly|negative regulation of stress fiber assembly|positive regulation of protein kinase B signaling|growth hormone receptor signaling pathway|positive regulation of focal adhesion disassembly|positive regulation of endoplasmic reticulum unfolded protein response|positive regulation of protein localization to plasma membrane|perinuclear endoplasmic reticulum membrane" "hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3R2 1740.019029 1686.856819 1793.181238 1.063031087 0.088183787 0.788090791 1 21.46566508 23.80160501 5296 phosphoinositide-3-kinase regulatory subunit 2 "GO:0001678,GO:0001784,GO:0005515,GO:0005634,GO:0005829,GO:0005942,GO:0006661,GO:0008286,GO:0010506,GO:0014065,GO:0015031,GO:0019903,GO:0030971,GO:0032869,GO:0034976,GO:0038095,GO:0038096,GO:0042307,GO:0043409,GO:0043551,GO:0045944,GO:0046854,GO:0046935,GO:0046982,GO:0048010,GO:0048015,GO:0050852,GO:0050900,GO:0051056,GO:0051897" cellular glucose homeostasis|phosphotyrosine residue binding|protein binding|nucleus|cytosol|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|insulin receptor signaling pathway|regulation of autophagy|phosphatidylinositol 3-kinase signaling|protein transport|protein phosphatase binding|receptor tyrosine kinase binding|cellular response to insulin stimulus|response to endoplasmic reticulum stress|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of protein import into nucleus|negative regulation of MAPK cascade|regulation of phosphatidylinositol 3-kinase activity|positive regulation of transcription by RNA polymerase II|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|protein heterodimerization activity|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|T cell receptor signaling pathway|leukocyte migration|regulation of small GTPase mediated signal transduction|positive regulation of protein kinase B signaling "hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3R3 12.04585964 15.22433953 8.867379749 0.582447582 -0.779799875 0.579059576 1 0.1261756 0.076656353 8503 phosphoinositide-3-kinase regulatory subunit 3 "GO:0001784,GO:0001934,GO:0002042,GO:0005515,GO:0005829,GO:0005942,GO:0006661,GO:0008286,GO:0010628,GO:0016303,GO:0030335,GO:0036092,GO:0043491,GO:0043551,GO:0046854,GO:0046935" phosphotyrosine residue binding|positive regulation of protein phosphorylation|cell migration involved in sprouting angiogenesis|protein binding|cytosol|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|insulin receptor signaling pathway|positive regulation of gene expression|1-phosphatidylinositol-3-kinase activity|positive regulation of cell migration|phosphatidylinositol-3-phosphate biosynthetic process|protein kinase B signaling|regulation of phosphatidylinositol 3-kinase activity|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity "hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3R4 868.7218912 890.1163843 847.3273982 0.951928774 -0.071074464 0.846886733 1 8.987490973 8.923985404 30849 phosphoinositide-3-kinase regulatory subunit 4 "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005770,GO:0005776,GO:0005829,GO:0005930,GO:0006468,GO:0006623,GO:0006661,GO:0015630,GO:0016020,GO:0016236,GO:0030242,GO:0030670,GO:0032465,GO:0032801,GO:0034162,GO:0034271,GO:0034272,GO:0035032,GO:0042149,GO:0043231,GO:0043552,GO:0045324,GO:0071561,GO:0106310,GO:0106311" "protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|late endosome|autophagosome|cytosol|axoneme|protein phosphorylation|protein targeting to vacuole|phosphatidylinositol biosynthetic process|microtubule cytoskeleton|membrane|macroautophagy|autophagy of peroxisome|phagocytic vesicle membrane|regulation of cytokinesis|receptor catabolic process|toll-like receptor 9 signaling pathway|phosphatidylinositol 3-kinase complex, class III, type I|phosphatidylinositol 3-kinase complex, class III, type II|phosphatidylinositol 3-kinase complex, class III|cellular response to glucose starvation|intracellular membrane-bounded organelle|positive regulation of phosphatidylinositol 3-kinase activity|late endosome to vacuole transport|nucleus-vacuole junction|protein serine kinase activity|protein threonine kinase activity" "hsa04136,hsa04140,hsa04371,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131" Autophagy - other|Autophagy - animal|Apelin signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis PIK3R6 13.70190557 27.40381115 0 0 #NAME? 0.000817682 0.080956814 0.38287072 0 146850 phosphoinositide-3-kinase regulatory subunit 6 "GO:0001525,GO:0005515,GO:0005829,GO:0005886,GO:0005942,GO:0005944,GO:0006661,GO:0007186,GO:0016020,GO:0030168,GO:0042269,GO:0043406,GO:0043551,GO:0045582,GO:0045766,GO:0046854,GO:0046934,GO:0046935" "angiogenesis|protein binding|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol 3-kinase complex, class IB|phosphatidylinositol biosynthetic process|G protein-coupled receptor signaling pathway|membrane|platelet activation|regulation of natural killer cell mediated cytotoxicity|positive regulation of MAP kinase activity|regulation of phosphatidylinositol 3-kinase activity|positive regulation of T cell differentiation|positive regulation of angiogenesis|phosphatidylinositol phosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|1-phosphatidylinositol-3-kinase regulator activity" "hsa04022,hsa04062,hsa04072,hsa04151,hsa04261,hsa04371,hsa04611,hsa04725,hsa04921,hsa05145,hsa05167" cGMP-PKG signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Platelet activation|Cholinergic synapse|Oxytocin signaling pathway|Toxoplasmosis|Kaposi sarcoma-associated herpesvirus infection PIKFYVE 1268.613551 1150.960068 1386.267034 1.204444075 0.268367407 0.429176264 1 5.816410607 7.307311598 200576 "phosphoinositide kinase, FYVE-type zinc finger containing" "GO:0000139,GO:0000285,GO:0004674,GO:0005515,GO:0005524,GO:0005829,GO:0005911,GO:0006612,GO:0006661,GO:0006898,GO:0008270,GO:0010008,GO:0016308,GO:0019065,GO:0019886,GO:0030593,GO:0030670,GO:0031901,GO:0031902,GO:0032288,GO:0032438,GO:0034504,GO:0035556,GO:0036092,GO:0036289,GO:0042147,GO:0043231,GO:0043813,GO:0045121,GO:0046854,GO:0048471,GO:0052810,GO:0090382,GO:0090385,GO:0106310,GO:0106311,GO:1903100,GO:1903426,GO:1904562,GO:2000785" "Golgi membrane|1-phosphatidylinositol-3-phosphate 5-kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|cell-cell junction|protein targeting to membrane|phosphatidylinositol biosynthetic process|receptor-mediated endocytosis|zinc ion binding|endosome membrane|1-phosphatidylinositol-4-phosphate 5-kinase activity|receptor-mediated endocytosis of virus by host cell|antigen processing and presentation of exogenous peptide antigen via MHC class II|neutrophil chemotaxis|phagocytic vesicle membrane|early endosome membrane|late endosome membrane|myelin assembly|melanosome organization|protein localization to nucleus|intracellular signal transduction|phosphatidylinositol-3-phosphate biosynthetic process|peptidyl-serine autophosphorylation|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|membrane raft|phosphatidylinositol phosphorylation|perinuclear region of cytoplasm|1-phosphatidylinositol-5-kinase activity|phagosome maturation|phagosome-lysosome fusion|protein serine kinase activity|protein threonine kinase activity|1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process|regulation of reactive oxygen species biosynthetic process|phosphatidylinositol 5-phosphate metabolic process|regulation of autophagosome assembly" "hsa00562,hsa04070,hsa04145,hsa04810" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Phagosome|Regulation of actin cytoskeleton PILRA 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.119729672 0.04041123 29992 paired immunoglobin like type 2 receptor alpha "GO:0005515,GO:0005886,GO:0007165,GO:0016021,GO:0016032,GO:0042288,GO:0050776,GO:0070062" protein binding|plasma membrane|signal transduction|integral component of membrane|viral process|MHC class I protein binding|regulation of immune response|extracellular exosome hsa05168 Herpes simplex virus 1 infection PILRB 365.5652656 338.9952934 392.1352378 1.156757174 0.210086047 0.640063726 1 11.48422455 13.85669977 29990 paired immunoglobin like type 2 receptor beta "GO:0005515,GO:0005886,GO:0005887,GO:0007169,GO:0007171,GO:0042288,GO:0050776" protein binding|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|activation of transmembrane receptor protein tyrosine kinase activity|MHC class I protein binding|regulation of immune response hsa05168 Herpes simplex virus 1 infection PIM1 379.2577686 298.3970547 460.1184825 1.541967239 0.624772114 0.156326209 1 5.59110549 8.992672198 5292 "Pim-1 proto-oncogene, serine/threonine kinase" "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0007049,GO:0007275,GO:0008134,GO:0019221,GO:0022898,GO:0030145,GO:0030212,GO:0043024,GO:0043066,GO:0043433,GO:0045893,GO:0046777,GO:0050821,GO:0060045,GO:0070561,GO:0090336,GO:0106310,GO:0106311,GO:1902033,GO:1905062,GO:1990748" "protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|apoptotic process|cell cycle|multicellular organism development|transcription factor binding|cytokine-mediated signaling pathway|regulation of transmembrane transporter activity|manganese ion binding|hyaluronan metabolic process|ribosomal small subunit binding|negative regulation of apoptotic process|negative regulation of DNA-binding transcription factor activity|positive regulation of transcription, DNA-templated|protein autophosphorylation|protein stabilization|positive regulation of cardiac muscle cell proliferation|vitamin D receptor signaling pathway|positive regulation of brown fat cell differentiation|protein serine kinase activity|protein threonine kinase activity|regulation of hematopoietic stem cell proliferation|positive regulation of cardioblast proliferation|cellular detoxification" "hsa04630,hsa04933,hsa05200,hsa05206,hsa05221" JAK-STAT signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer|MicroRNAs in cancer|Acute myeloid leukemia PIM2 537.1064323 514.582676 559.6301886 1.087541837 0.121070901 0.766318876 1 12.55990226 14.24781156 11040 "Pim-2 proto-oncogene, serine/threonine kinase" "GO:0000082,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0006915,GO:0007346,GO:0008285,GO:0009615,GO:0010508,GO:0043066,GO:0043123,GO:0045893,GO:0046777,GO:0050821,GO:0106310,GO:0106311" "G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|apoptotic process|regulation of mitotic cell cycle|negative regulation of cell population proliferation|response to virus|positive regulation of autophagy|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|protein autophosphorylation|protein stabilization|protein serine kinase activity|protein threonine kinase activity" "hsa05200,hsa05221" Pathways in cancer|Acute myeloid leukemia PIM3 888.2396277 809.9348628 966.5443926 1.193360648 0.255030109 0.479385495 1 19.51491128 24.29149386 415116 "Pim-3 proto-oncogene, serine/threonine kinase" "GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006915,GO:0007049,GO:0007346,GO:0043066,GO:0046777,GO:0061179,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|protein phosphorylation|apoptotic process|cell cycle|regulation of mitotic cell cycle|negative regulation of apoptotic process|protein autophosphorylation|negative regulation of insulin secretion involved in cellular response to glucose stimulus|protein serine kinase activity|protein threonine kinase activity PIMREG 707.8189571 599.8389773 815.7989369 1.360029888 0.443638356 0.239230929 1 13.31860066 18.89395947 54478 PICALM interacting mitotic regulator "GO:0005515,GO:0005654,GO:0005730,GO:0007049,GO:0051301" protein binding|nucleoplasm|nucleolus|cell cycle|cell division PIN1 776.3878681 740.9178569 811.8578792 1.095746137 0.131913592 0.72336606 1 33.32582207 38.08962957 5300 "peptidylprolyl cis/trans isomerase, NIMA-interacting 1" "GO:0000413,GO:0001666,GO:0001932,GO:0001934,GO:0003755,GO:0003774,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0007049,GO:0007088,GO:0008013,GO:0010468,GO:0016607,GO:0016859,GO:0030182,GO:0030496,GO:0030512,GO:0031434,GO:0031647,GO:0032091,GO:0032092,GO:0032465,GO:0032480,GO:0032794,GO:0035307,GO:0036064,GO:0042177,GO:0043005,GO:0043524,GO:0043525,GO:0043547,GO:0045944,GO:0046785,GO:0048156,GO:0050808,GO:0050815,GO:0050816,GO:0050821,GO:0051219,GO:0051443,GO:0060393,GO:0061051,GO:0070373,GO:0090263,GO:0098978,GO:0099524,GO:1900180,GO:1901796,GO:1902430,GO:2000146" protein peptidyl-prolyl isomerization|response to hypoxia|regulation of protein phosphorylation|positive regulation of protein phosphorylation|peptidyl-prolyl cis-trans isomerase activity|motor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|cell cycle|regulation of mitotic nuclear division|beta-catenin binding|regulation of gene expression|nuclear speck|cis-trans isomerase activity|neuron differentiation|midbody|negative regulation of transforming growth factor beta receptor signaling pathway|mitogen-activated protein kinase kinase binding|regulation of protein stability|negative regulation of protein binding|positive regulation of protein binding|regulation of cytokinesis|negative regulation of type I interferon production|GTPase activating protein binding|positive regulation of protein dephosphorylation|ciliary basal body|negative regulation of protein catabolic process|neuron projection|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|positive regulation of GTPase activity|positive regulation of transcription by RNA polymerase II|microtubule polymerization|tau protein binding|synapse organization|phosphoserine residue binding|phosphothreonine residue binding|protein stabilization|phosphoprotein binding|positive regulation of ubiquitin-protein transferase activity|regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of cell growth involved in cardiac muscle cell development|negative regulation of ERK1 and ERK2 cascade|positive regulation of canonical Wnt signaling pathway|glutamatergic synapse|postsynaptic cytosol|regulation of protein localization to nucleus|regulation of signal transduction by p53 class mediator|negative regulation of amyloid-beta formation|negative regulation of cell motility hsa04622 RIG-I-like receptor signaling pathway PIN4 281.4345216 279.1128913 283.756152 1.01663578 0.023802912 0.968750573 1 5.483352713 5.81470254 5303 "peptidylprolyl cis/trans isomerase, NIMA-interacting 4" "GO:0000413,GO:0003677,GO:0003723,GO:0003755,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005759,GO:0005819,GO:0006364" protein peptidyl-prolyl isomerization|DNA binding|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleoplasm|chromosome|nucleolus|mitochondrial matrix|spindle|rRNA processing PINK1 1170.558215 1048.449515 1292.666915 1.232931959 0.302093185 0.379241169 1 19.98504676 25.70160285 65018 PTEN induced kinase 1 "GO:0000287,GO:0000422,GO:0000785,GO:0001934,GO:0002020,GO:0002082,GO:0002931,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005783,GO:0005829,GO:0005856,GO:0006468,GO:0006511,GO:0006979,GO:0007005,GO:0010310,GO:0010629,GO:0010821,GO:0010857,GO:0010952,GO:0016020,GO:0016236,GO:0016239,GO:0016242,GO:0016301,GO:0016504,GO:0016567,GO:0018105,GO:0022904,GO:0030424,GO:0030426,GO:0031307,GO:0031396,GO:0031398,GO:0031625,GO:0032148,GO:0032226,GO:0033138,GO:0033603,GO:0034599,GO:0035307,GO:0035556,GO:0036289,GO:0038203,GO:0042981,GO:0043123,GO:0043254,GO:0043422,GO:0043524,GO:0044297,GO:0044877,GO:0045727,GO:0046329,GO:0048471,GO:0050821,GO:0051091,GO:0051443,GO:0051881,GO:0051897,GO:0055131,GO:0061136,GO:0071456,GO:0072655,GO:0072656,GO:0090141,GO:0090200,GO:0090258,GO:0097237,GO:0097413,GO:0097449,GO:0098779,GO:0099074,GO:0106310,GO:0106311,GO:1900407,GO:1901727,GO:1902803,GO:1902902,GO:1902958,GO:1903146,GO:1903147,GO:1903202,GO:1903204,GO:1903214,GO:1903298,GO:1903384,GO:1903751,GO:1903852,GO:1903955,GO:1904544,GO:1904783,GO:1904841,GO:1904881,GO:2000377,GO:2000378,GO:2001171,GO:2001243" "magnesium ion binding|autophagy of mitochondrion|chromatin|positive regulation of protein phosphorylation|protease binding|regulation of oxidative phosphorylation|response to ischemia|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|endoplasmic reticulum|cytosol|cytoskeleton|protein phosphorylation|ubiquitin-dependent protein catabolic process|response to oxidative stress|mitochondrion organization|regulation of hydrogen peroxide metabolic process|negative regulation of gene expression|regulation of mitochondrion organization|calcium-dependent protein kinase activity|positive regulation of peptidase activity|membrane|macroautophagy|positive regulation of macroautophagy|negative regulation of macroautophagy|kinase activity|peptidase activator activity|protein ubiquitination|peptidyl-serine phosphorylation|respiratory electron transport chain|axon|growth cone|integral component of mitochondrial outer membrane|regulation of protein ubiquitination|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|activation of protein kinase B activity|positive regulation of synaptic transmission, dopaminergic|positive regulation of peptidyl-serine phosphorylation|positive regulation of dopamine secretion|cellular response to oxidative stress|positive regulation of protein dephosphorylation|intracellular signal transduction|peptidyl-serine autophosphorylation|TORC2 signaling|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of protein-containing complex assembly|protein kinase B binding|negative regulation of neuron apoptotic process|cell body|protein-containing complex binding|positive regulation of translation|negative regulation of JNK cascade|perinuclear region of cytoplasm|protein stabilization|positive regulation of DNA-binding transcription factor activity|positive regulation of ubiquitin-protein transferase activity|regulation of mitochondrial membrane potential|positive regulation of protein kinase B signaling|C3HC4-type RING finger domain binding|regulation of proteasomal protein catabolic process|cellular response to hypoxia|establishment of protein localization to mitochondrion|maintenance of protein location in mitochondrion|positive regulation of mitochondrial fission|positive regulation of release of cytochrome c from mitochondria|negative regulation of mitochondrial fission|cellular response to toxic substance|Lewy body|astrocyte projection|positive regulation of mitophagy in response to mitochondrial depolarization|mitochondrion to lysosome transport|protein serine kinase activity|protein threonine kinase activity|regulation of cellular response to oxidative stress|positive regulation of histone deacetylase activity|regulation of synaptic vesicle transport|negative regulation of autophagosome assembly|positive regulation of mitochondrial electron transport, NADH to ubiquinone|regulation of autophagy of mitochondrion|negative regulation of autophagy of mitochondrion|negative regulation of oxidative stress-induced cell death|negative regulation of oxidative stress-induced neuron death|regulation of protein targeting to mitochondrion|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|positive regulation of cristae formation|positive regulation of protein targeting to mitochondrion|positive regulation of free ubiquitin chain polymerization|positive regulation of NMDA glutamate receptor activity|TORC2 complex binding|cellular response to hydrogen sulfide|regulation of reactive oxygen species metabolic process|negative regulation of reactive oxygen species metabolic process|positive regulation of ATP biosynthetic process|negative regulation of intrinsic apoptotic signaling pathway" "hsa04137,hsa05012,hsa05014,hsa05022" Mitophagy - animal|Parkinson disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases PINLYP 77.8277241 100.4806409 55.17480733 0.549108832 -0.864835979 0.24135133 1 3.576240327 2.048335325 390940 phospholipase A2 inhibitor and LY6/PLAUR domain containing "GO:0004859,GO:0005576,GO:0043086" phospholipase inhibitor activity|extracellular region|negative regulation of catalytic activity PINX1 170.1941604 218.2155332 122.1727877 0.559872095 -0.83683082 0.141526916 1 7.148672017 4.174746636 54984 PIN2 (TERF1) interacting telomerase inhibitor 1 "GO:0000228,GO:0000776,GO:0000777,GO:0000781,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005819,GO:0007004,GO:0007080,GO:0008285,GO:0010521,GO:0010972,GO:0031397,GO:0031647,GO:0032211,GO:0044877,GO:0051972,GO:0051974,GO:0070034,GO:0070198,GO:1902570,GO:1904357,GO:1904744,GO:1904751" "nuclear chromosome|kinetochore|condensed chromosome kinetochore|chromosome, telomeric region|protein binding|nucleoplasm|nucleolus|mitochondrion|spindle|telomere maintenance via telomerase|mitotic metaphase plate congression|negative regulation of cell population proliferation|telomerase inhibitor activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of protein ubiquitination|regulation of protein stability|negative regulation of telomere maintenance via telomerase|protein-containing complex binding|regulation of telomerase activity|negative regulation of telomerase activity|telomerase RNA binding|protein localization to chromosome, telomeric region|protein localization to nucleolus|negative regulation of telomere maintenance via telomere lengthening|positive regulation of telomeric DNA binding|positive regulation of protein localization to nucleolus" PIP4K2A 759.5262878 834.293806 684.7587695 0.820764537 -0.284959697 0.443383978 1 9.609742566 8.227090352 5305 phosphatidylinositol-5-phosphate 4-kinase type 2 alpha "GO:0005515,GO:0005524,GO:0005654,GO:0005764,GO:0005776,GO:0005829,GO:0005886,GO:0006644,GO:0006661,GO:0010506,GO:0014066,GO:0016308,GO:0016309,GO:0035855,GO:0042803,GO:0046627,GO:0046854,GO:0061909,GO:0090119,GO:0090217,GO:1902635,GO:2000786" "protein binding|ATP binding|nucleoplasm|lysosome|autophagosome|cytosol|plasma membrane|phospholipid metabolic process|phosphatidylinositol biosynthetic process|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|megakaryocyte development|protein homodimerization activity|negative regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|autophagosome-lysosome fusion|vesicle-mediated cholesterol transport|negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|positive regulation of autophagosome assembly" "hsa00562,hsa04070,hsa04810" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Regulation of actin cytoskeleton PIP4K2B 3307.828831 3152.453238 3463.204424 1.0985744 0.135632578 0.670186796 1 29.59418634 33.91187543 8396 phosphatidylinositol-5-phosphate 4-kinase type 2 beta "GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005776,GO:0005789,GO:0005829,GO:0005886,GO:0006644,GO:0006661,GO:0007166,GO:0010506,GO:0014066,GO:0016308,GO:0016309,GO:0042803,GO:0046627,GO:0046854,GO:0061909,GO:0090217,GO:1902635,GO:2000786" "protein binding|ATP binding|GTP binding|nucleus|nucleoplasm|autophagosome|endoplasmic reticulum membrane|cytosol|plasma membrane|phospholipid metabolic process|phosphatidylinositol biosynthetic process|cell surface receptor signaling pathway|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|protein homodimerization activity|negative regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|autophagosome-lysosome fusion|negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|positive regulation of autophagosome assembly" "hsa00562,hsa04070,hsa04810" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Regulation of actin cytoskeleton PIP4K2C 1176.296849 1339.741878 1012.85182 0.756005195 -0.403531946 0.239669126 1 20.24864214 15.9674886 79837 phosphatidylinositol-5-phosphate 4-kinase type 2 gamma "GO:0005515,GO:0005524,GO:0005654,GO:0005776,GO:0005783,GO:0005829,GO:0005886,GO:0006661,GO:0010506,GO:0014066,GO:0016308,GO:0016309,GO:0042802,GO:0043229,GO:0046627,GO:0046854,GO:0070062,GO:0090217,GO:1902635,GO:2000786" "protein binding|ATP binding|nucleoplasm|autophagosome|endoplasmic reticulum|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|identical protein binding|intracellular organelle|negative regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|extracellular exosome|negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|positive regulation of autophagosome assembly" "hsa00562,hsa04070,hsa04810" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Regulation of actin cytoskeleton PIP4P1 661.9150871 593.7492415 730.0809327 1.229611563 0.298202637 0.43615556 1 14.88678439 19.09346575 90809 "phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1" "GO:0005515,GO:0005654,GO:0005765,GO:0005886,GO:0006644,GO:0006991,GO:0008203,GO:0016021,GO:0030670,GO:0031902,GO:0032418,GO:0034597,GO:0046856,GO:0070070,GO:1904263" "protein binding|nucleoplasm|lysosomal membrane|plasma membrane|phospholipid metabolic process|response to sterol depletion|cholesterol metabolic process|integral component of membrane|phagocytic vesicle membrane|late endosome membrane|lysosome localization|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|phosphatidylinositol dephosphorylation|proton-transporting V-type ATPase complex assembly|positive regulation of TORC1 signaling" hsa04070 Phosphatidylinositol signaling system PIP4P2 483.4325322 415.1169911 551.7480733 1.329138737 0.410491703 0.31965299 1 6.93639431 9.616566043 55529 "phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2" "GO:0005515,GO:0005765,GO:0005886,GO:0016021,GO:0030670,GO:0031902,GO:0034597,GO:0046856,GO:0050765" "protein binding|lysosomal membrane|plasma membrane|integral component of membrane|phagocytic vesicle membrane|late endosome membrane|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|phosphatidylinositol dephosphorylation|negative regulation of phagocytosis" hsa04070 Phosphatidylinositol signaling system PIP5K1A 3402.054949 3532.04677 3272.063127 0.926392922 -0.110303864 0.729249331 1 38.01226277 36.73118002 8394 phosphatidylinositol-4-phosphate 5-kinase type 1 alpha "GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005847,GO:0005886,GO:0005925,GO:0006650,GO:0006661,GO:0006909,GO:0007165,GO:0008654,GO:0010761,GO:0014066,GO:0016308,GO:0016477,GO:0016607,GO:0019900,GO:0030027,GO:0030216,GO:0031532,GO:0032587,GO:0046854,GO:0048041,GO:0060326,GO:0072659,GO:0090630,GO:0097178" protein binding|ATP binding|nucleus|nucleoplasm|cytosol|mRNA cleavage and polyadenylation specificity factor complex|plasma membrane|focal adhesion|glycerophospholipid metabolic process|phosphatidylinositol biosynthetic process|phagocytosis|signal transduction|phospholipid biosynthetic process|fibroblast migration|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|cell migration|nuclear speck|kinase binding|lamellipodium|keratinocyte differentiation|actin cytoskeleton reorganization|ruffle membrane|phosphatidylinositol phosphorylation|focal adhesion assembly|cell chemotaxis|protein localization to plasma membrane|activation of GTPase activity|ruffle assembly "hsa00562,hsa04070,hsa04072,hsa04144,hsa04510,hsa04666,hsa04810,hsa05135,hsa05231" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Endocytosis|Focal adhesion|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Yersinia infection|Choline metabolism in cancer PIP5K1C 1508.021672 1655.393184 1360.650159 0.821949838 -0.282877744 0.393411669 1 10.60592346 9.093053204 23396 phosphatidylinositol-4-phosphate 5-kinase type 1 gamma "GO:0001891,GO:0001931,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005912,GO:0005925,GO:0006661,GO:0006909,GO:0010008,GO:0014066,GO:0016079,GO:0016308,GO:0030036,GO:0030593,GO:0032587,GO:0034333,GO:0046854,GO:0048488,GO:0061024,GO:0072583,GO:0098609,GO:0098793" phagocytic cup|uropod|protein binding|ATP binding|nucleoplasm|cytosol|adherens junction|focal adhesion|phosphatidylinositol biosynthetic process|phagocytosis|endosome membrane|regulation of phosphatidylinositol 3-kinase signaling|synaptic vesicle exocytosis|1-phosphatidylinositol-4-phosphate 5-kinase activity|actin cytoskeleton organization|neutrophil chemotaxis|ruffle membrane|adherens junction assembly|phosphatidylinositol phosphorylation|synaptic vesicle endocytosis|membrane organization|clathrin-dependent endocytosis|cell-cell adhesion|presynapse "hsa00562,hsa04070,hsa04072,hsa04144,hsa04510,hsa04666,hsa04810,hsa05135,hsa05231" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Endocytosis|Focal adhesion|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Yersinia infection|Choline metabolism in cancer PIP5KL1 68.57435418 74.09178569 63.05692266 0.85106496 -0.23265884 0.775856906 1 1.11780982 0.992308155 138429 phosphatidylinositol-4-phosphate 5-kinase like 1 "GO:0001933,GO:0005524,GO:0005829,GO:0010917,GO:0016020,GO:0016308,GO:0030336,GO:0042995,GO:0043065,GO:0046854" negative regulation of protein phosphorylation|ATP binding|cytosol|negative regulation of mitochondrial membrane potential|membrane|1-phosphatidylinositol-4-phosphate 5-kinase activity|negative regulation of cell migration|cell projection|positive regulation of apoptotic process|phosphatidylinositol phosphorylation "hsa00562,hsa04144" Inositol phosphate metabolism|Endocytosis PIR 129.5932001 170.5126027 88.67379749 0.520042484 -0.943298608 0.130304532 1 6.602340821 3.581398879 8544 pirin "GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006366,GO:0007586,GO:0008127,GO:0030224,GO:0046872,GO:0055114" "transcription coregulator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription by RNA polymerase II|digestion|quercetin 2,3-dioxygenase activity|monocyte differentiation|metal ion binding|oxidation-reduction process" PISD 1493.555705 1845.189951 1141.921459 0.618863905 -0.692305914 0.037384514 0.877615824 28.44820747 18.36394528 23761 phosphatidylserine decarboxylase "GO:0004609,GO:0005634,GO:0005739,GO:0006646,GO:0016540,GO:0031305" phosphatidylserine decarboxylase activity|nucleus|mitochondrion|phosphatidylethanolamine biosynthetic process|protein autoprocessing|integral component of mitochondrial inner membrane hsa00564 Glycerophospholipid metabolism PITHD1 479.2188073 463.8348775 494.6027371 1.066333648 0.092658918 0.826745391 1 14.76530499 16.42296114 57095 PITH domain containing 1 "GO:0005634,GO:0005737,GO:0007286,GO:0007341,GO:0045654,GO:0045893,GO:0061136,GO:0061956,GO:0097598" "nucleus|cytoplasm|spermatid development|penetration of zona pellucida|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|regulation of proteasomal protein catabolic process|penetration of cumulus oophorus|sperm cytoplasmic droplet" PITPNA 2389.712829 2219.708703 2559.716954 1.153176969 0.205613929 0.520046668 1 28.83314058 34.68197648 5306 phosphatidylinositol transfer protein alpha "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006629,GO:0007601,GO:0008525,GO:0008526,GO:0015914,GO:0031210,GO:0035091,GO:0035722,GO:0070062,GO:0120009,GO:0120019,GO:1901611" protein binding|nucleus|cytoplasm|cytosol|lipid metabolic process|visual perception|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|phospholipid transport|phosphatidylcholine binding|phosphatidylinositol binding|interleukin-12-mediated signaling pathway|extracellular exosome|intermembrane lipid transfer|phosphatidylcholine transfer activity|phosphatidylglycerol binding PITPNB 2229.865182 2169.97586 2289.754504 1.055198146 0.077513934 0.809782853 1 34.49517329 37.96717466 23760 phosphatidylinositol transfer protein beta "GO:0000139,GO:0005515,GO:0005737,GO:0005789,GO:0005794,GO:0006629,GO:0006890,GO:0006997,GO:0008525,GO:0008526,GO:0015914,GO:0031210,GO:0035091,GO:0120009,GO:0120019,GO:0140338" "Golgi membrane|protein binding|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|lipid metabolic process|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|nucleus organization|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|phospholipid transport|phosphatidylcholine binding|phosphatidylinositol binding|intermembrane lipid transfer|phosphatidylcholine transfer activity|sphingomyelin transfer activity" PITPNC1 240.9523275 239.5296085 242.3750465 1.011879274 0.017037175 0.982390993 1 1.876752732 1.980850444 26207 phosphatidylinositol transfer protein cytoplasmic 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0008525,GO:0008526,GO:0015914,GO:0035091,GO:0070300,GO:0120009,GO:1901611,GO:1990050" protein binding|nucleoplasm|cytoplasm|cytosol|signal transduction|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|phospholipid transport|phosphatidylinositol binding|phosphatidic acid binding|intermembrane lipid transfer|phosphatidylglycerol binding|phosphatidic acid transfer activity PITPNM1 1875.031183 1857.369422 1892.692944 1.019018038 0.027179589 0.934796904 1 21.04456573 22.36854675 9600 phosphatidylinositol transfer protein membrane associated 1 "GO:0005509,GO:0005515,GO:0005737,GO:0005789,GO:0005811,GO:0005829,GO:0006629,GO:0006661,GO:0007420,GO:0007602,GO:0008525,GO:0008526,GO:0015031,GO:0015914,GO:0016020,GO:0030496,GO:0030971,GO:0031210,GO:0032154,GO:0032580,GO:0035091,GO:0043231,GO:0044297,GO:0070300,GO:0120009" calcium ion binding|protein binding|cytoplasm|endoplasmic reticulum membrane|lipid droplet|cytosol|lipid metabolic process|phosphatidylinositol biosynthetic process|brain development|phototransduction|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|protein transport|phospholipid transport|membrane|midbody|receptor tyrosine kinase binding|phosphatidylcholine binding|cleavage furrow|Golgi cisterna membrane|phosphatidylinositol binding|intracellular membrane-bounded organelle|cell body|phosphatidic acid binding|intermembrane lipid transfer PITPNM2 571.2828849 628.2577444 514.3080254 0.818625843 -0.288723884 0.466331326 1 3.892713285 3.323944758 57605 phosphatidylinositol transfer protein membrane associated 2 "GO:0005509,GO:0005737,GO:0005829,GO:0006661,GO:0008525,GO:0008526,GO:0012505,GO:0015914,GO:0016020,GO:0030971,GO:0031210,GO:0035091,GO:0044297,GO:0048015,GO:0120009" calcium ion binding|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|endomembrane system|phospholipid transport|membrane|receptor tyrosine kinase binding|phosphatidylcholine binding|phosphatidylinositol binding|cell body|phosphatidylinositol-mediated signaling|intermembrane lipid transfer PITPNM3 51.72366027 33.49354696 69.95377357 2.088574664 1.062518719 0.207745729 1 0.177125404 0.38587513 83394 PITPNM family member 3 "GO:0004620,GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0006661,GO:0008289,GO:0012505,GO:0016020,GO:0030134,GO:0030971,GO:0042995,GO:0044297" phospholipase activity|calcium ion binding|protein binding|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|lipid binding|endomembrane system|membrane|COPII-coated ER to Golgi transport vesicle|receptor tyrosine kinase binding|cell projection|cell body PITRM1 2506.007681 2356.727759 2655.287603 1.126684061 0.17208302 0.590016533 1 30.09580104 35.36909826 10531 pitrilysin metallopeptidase 1 "GO:0004222,GO:0005739,GO:0005759,GO:0006508,GO:0006626,GO:0008047,GO:0008237,GO:0008270,GO:0016485,GO:0050790" metalloendopeptidase activity|mitochondrion|mitochondrial matrix|proteolysis|protein targeting to mitochondrion|enzyme activator activity|metallopeptidase activity|zinc ion binding|protein processing|regulation of catalytic activity PITX1 619.6580808 533.8668394 705.4493222 1.321395656 0.402062507 0.300459368 1 11.56973558 15.94675191 5307 paired like homeodomain 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001228,GO:0001501,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0009653,GO:0014707,GO:0021983,GO:0035116,GO:0045892,GO:0045944,GO:0048625,GO:0051216,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|branchiomeric skeletal muscle development|pituitary gland development|embryonic hindlimb morphogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|myoblast fate commitment|cartilage development|sequence-specific double-stranded DNA binding" Homeobox PITX3 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.10814293 0.036500465 5309 paired like homeodomain 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002088,GO:0002089,GO:0005634,GO:0006355,GO:0006357,GO:0007568,GO:0007626,GO:0009653,GO:0009887,GO:0014014,GO:0030901,GO:0035902,GO:0042220,GO:0043025,GO:0043278,GO:0043525,GO:0045893,GO:0045944,GO:0048666,GO:0070306,GO:0071542,GO:1904313,GO:1904935,GO:1990792,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|lens development in camera-type eye|lens morphogenesis in camera-type eye|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|aging|locomotory behavior|anatomical structure morphogenesis|animal organ morphogenesis|negative regulation of gliogenesis|midbrain development|response to immobilization stress|response to cocaine|neuronal cell body|response to morphine|positive regulation of neuron apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|neuron development|lens fiber cell differentiation|dopaminergic neuron differentiation|response to methamphetamine hydrochloride|positive regulation of cell proliferation in midbrain|cellular response to glial cell derived neurotrophic factor|sequence-specific double-stranded DNA binding" PIWIL2 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.026847461 0.009061571 55124 piwi like RNA-mediated gene silencing 2 "GO:0000966,GO:0003729,GO:0004521,GO:0005515,GO:0005634,GO:0005737,GO:0007275,GO:0007283,GO:0010370,GO:0010529,GO:0030718,GO:0031047,GO:0033391,GO:0034584,GO:0034587,GO:0042754,GO:0043046,GO:0043186,GO:0045727,GO:0046872,GO:0048477,GO:0048511,GO:0051321,GO:0060903,GO:0071442,GO:0071546,GO:0090502,GO:0097433,GO:1905538,GO:1990511,GO:1990923,GO:2000617" "RNA 5'-end processing|mRNA binding|endoribonuclease activity|protein binding|nucleus|cytoplasm|multicellular organism development|spermatogenesis|perinucleolar chromocenter|negative regulation of transposition|germ-line stem cell population maintenance|gene silencing by RNA|chromatoid body|piRNA binding|piRNA metabolic process|negative regulation of circadian rhythm|DNA methylation involved in gamete generation|P granule|positive regulation of translation|metal ion binding|oogenesis|rhythmic process|meiotic cell cycle|positive regulation of meiosis I|positive regulation of histone H3-K14 acetylation|pi-body|RNA phosphodiester bond hydrolysis, endonucleolytic|dense body|polysome binding|piRNA biosynthetic process|PET complex|positive regulation of histone H3-K9 acetylation" PJA1 534.8511121 528.7920595 540.9101647 1.022916579 0.032688495 0.940035714 1 9.554567374 10.19452921 64219 praja ring finger ubiquitin ligase 1 "GO:0005515,GO:0005737,GO:0016567,GO:0030163,GO:0046872,GO:0061630" protein binding|cytoplasm|protein ubiquitination|protein catabolic process|metal ion binding|ubiquitin protein ligase activity PJA2 3348.371892 2994.120107 3702.623677 1.236631647 0.306415831 0.335497695 1 30.38910236 39.19892509 9867 praja ring finger ubiquitin ligase 2 "GO:0000139,GO:0004842,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0006954,GO:0007616,GO:0010738,GO:0014069,GO:0016567,GO:0034137,GO:0034236,GO:0034237,GO:0035329,GO:0043030,GO:0045087,GO:0045111,GO:0046330,GO:0046872,GO:1900745" Golgi membrane|ubiquitin-protein transferase activity|protein binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|inflammatory response|long-term memory|regulation of protein kinase A signaling|postsynaptic density|protein ubiquitination|positive regulation of toll-like receptor 2 signaling pathway|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|hippo signaling|regulation of macrophage activation|innate immune response|intermediate filament cytoskeleton|positive regulation of JNK cascade|metal ion binding|positive regulation of p38MAPK cascade PJVK 45.64604863 55.82257826 35.469519 0.635397363 -0.654268993 0.45908739 1 0.868043187 0.57531099 494513 pejvakin "GO:0000302,GO:0000425,GO:0005737,GO:0005778,GO:0007605,GO:0030864,GO:0035253,GO:0043025,GO:0050910,GO:0097468,GO:0120044,GO:0120045,GO:1900063" response to reactive oxygen species|pexophagy|cytoplasm|peroxisomal membrane|sensory perception of sound|cortical actin cytoskeleton|ciliary rootlet|neuronal cell body|detection of mechanical stimulus involved in sensory perception of sound|programmed cell death in response to reactive oxygen species|stereocilium base|stereocilium maintenance|regulation of peroxisome organization PKD1 1395.068849 1174.304055 1615.833643 1.37599256 0.460472669 0.169084849 1 4.002581446 5.744764014 5310 "polycystin 1, transient receptor potential channel interacting" "GO:0000139,GO:0001502,GO:0001701,GO:0001822,GO:0001889,GO:0001892,GO:0002133,GO:0005262,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005929,GO:0006611,GO:0007050,GO:0007156,GO:0007160,GO:0007161,GO:0007204,GO:0007259,GO:0007507,GO:0009653,GO:0009986,GO:0016021,GO:0016055,GO:0016323,GO:0016328,GO:0018105,GO:0019901,GO:0019904,GO:0021510,GO:0021915,GO:0030010,GO:0030155,GO:0030246,GO:0030660,GO:0031514,GO:0032092,GO:0034405,GO:0034703,GO:0034704,GO:0036303,GO:0042813,GO:0042994,GO:0043588,GO:0044325,GO:0045737,GO:0045944,GO:0048565,GO:0048754,GO:0048806,GO:0050982,GO:0051216,GO:0051290,GO:0060170,GO:0060236,GO:0060428,GO:0060674,GO:0061136,GO:0070062,GO:0070588,GO:0072164,GO:0072177,GO:0072205,GO:0072218,GO:0072237,GO:0072287,GO:0198738,GO:2000045" Golgi membrane|cartilage condensation|in utero embryonic development|kidney development|liver development|embryonic placenta development|polycystin complex|calcium channel activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|cilium|protein export from nucleus|cell cycle arrest|homophilic cell adhesion via plasma membrane adhesion molecules|cell-matrix adhesion|calcium-independent cell-matrix adhesion|positive regulation of cytosolic calcium ion concentration|receptor signaling pathway via JAK-STAT|heart development|anatomical structure morphogenesis|cell surface|integral component of membrane|Wnt signaling pathway|basolateral plasma membrane|lateral plasma membrane|peptidyl-serine phosphorylation|protein kinase binding|protein domain specific binding|spinal cord development|neural tube development|establishment of cell polarity|regulation of cell adhesion|carbohydrate binding|Golgi-associated vesicle membrane|motile cilium|positive regulation of protein binding|response to fluid shear stress|cation channel complex|calcium channel complex|lymph vessel morphogenesis|Wnt-activated receptor activity|cytoplasmic sequestering of transcription factor|skin development|ion channel binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|digestive tract development|branching morphogenesis of an epithelial tube|genitalia development|detection of mechanical stimulus|cartilage development|protein heterotetramerization|ciliary membrane|regulation of mitotic spindle organization|lung epithelium development|placenta blood vessel development|regulation of proteasomal protein catabolic process|extracellular exosome|calcium ion transmembrane transport|mesonephric tubule development|mesonephric duct development|metanephric collecting duct development|metanephric ascending thin limb development|metanephric proximal tubule development|metanephric distal tubule morphogenesis|cell-cell signaling by wnt|regulation of G1/S transition of mitotic cell cycle PKD1L1 64.72237116 80.1815215 49.26322083 0.614396184 -0.70275884 0.371402673 1 0.256646097 0.1644747 168507 "polycystin 1 like 1, transient receptor potential channel interacting" "GO:0003127,GO:0005262,GO:0005515,GO:0005929,GO:0016020,GO:0034704,GO:0050982,GO:0060170,GO:0070588,GO:0070986,GO:0097730,GO:0098609" detection of nodal flow|calcium channel activity|protein binding|cilium|membrane|calcium channel complex|detection of mechanical stimulus|ciliary membrane|calcium ion transmembrane transport|left/right axis specification|non-motile cilium|cell-cell adhesion PKD2 857.3374106 819.0694665 895.6053546 1.093442487 0.12887734 0.724171572 1 7.865562945 8.971017124 5311 "polycystin 2, transient receptor potential cation channel" "GO:0001658,GO:0001889,GO:0001892,GO:0001947,GO:0002133,GO:0003127,GO:0005102,GO:0005244,GO:0005245,GO:0005248,GO:0005249,GO:0005261,GO:0005262,GO:0005267,GO:0005509,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0005911,GO:0005929,GO:0006816,GO:0007050,GO:0007259,GO:0007368,GO:0007507,GO:0008092,GO:0008285,GO:0009925,GO:0015271,GO:0016020,GO:0016055,GO:0021510,GO:0021915,GO:0022843,GO:0030027,GO:0030659,GO:0031514,GO:0031587,GO:0031941,GO:0034614,GO:0034703,GO:0035502,GO:0035725,GO:0035904,GO:0036064,GO:0042127,GO:0042802,GO:0042803,GO:0042805,GO:0042994,GO:0043398,GO:0044325,GO:0044782,GO:0045180,GO:0045429,GO:0045737,GO:0045944,GO:0048763,GO:0050982,GO:0051117,GO:0051209,GO:0051219,GO:0051262,GO:0051289,GO:0051290,GO:0051298,GO:0051371,GO:0060170,GO:0060315,GO:0060674,GO:0061333,GO:0061441,GO:0070062,GO:0070588,GO:0071158,GO:0071277,GO:0071320,GO:0071458,GO:0071464,GO:0071470,GO:0071498,GO:0071556,GO:0071805,GO:0071910,GO:0072075,GO:0072164,GO:0072177,GO:0072208,GO:0072214,GO:0072218,GO:0072219,GO:0072235,GO:0072284,GO:0072686,GO:0090279,GO:0097730,GO:0098662,GO:0198738,GO:2000134" "branching involved in ureteric bud morphogenesis|liver development|embryonic placenta development|heart looping|polycystin complex|detection of nodal flow|signaling receptor binding|voltage-gated ion channel activity|voltage-gated calcium channel activity|voltage-gated sodium channel activity|voltage-gated potassium channel activity|cation channel activity|calcium channel activity|potassium channel activity|calcium ion binding|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell-cell junction|cilium|calcium ion transport|cell cycle arrest|receptor signaling pathway via JAK-STAT|determination of left/right symmetry|heart development|cytoskeletal protein binding|negative regulation of cell population proliferation|basal plasma membrane|outward rectifier potassium channel activity|membrane|Wnt signaling pathway|spinal cord development|neural tube development|voltage-gated cation channel activity|lamellipodium|cytoplasmic vesicle membrane|motile cilium|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|filamentous actin|cellular response to reactive oxygen species|cation channel complex|metanephric part of ureteric bud development|sodium ion transmembrane transport|aorta development|ciliary basal body|regulation of cell population proliferation|identical protein binding|protein homodimerization activity|actinin binding|cytoplasmic sequestering of transcription factor|HLH domain binding|ion channel binding|cilium organization|basal cortex|positive regulation of nitric oxide biosynthetic process|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|calcium-induced calcium release activity|detection of mechanical stimulus|ATPase binding|release of sequestered calcium ion into cytosol|phosphoprotein binding|protein tetramerization|protein homotetramerization|protein heterotetramerization|centrosome duplication|muscle alpha-actinin binding|ciliary membrane|negative regulation of ryanodine-sensitive calcium-release channel activity|placenta blood vessel development|renal tubule morphogenesis|renal artery morphogenesis|extracellular exosome|calcium ion transmembrane transport|positive regulation of cell cycle arrest|cellular response to calcium ion|cellular response to cAMP|integral component of cytoplasmic side of endoplasmic reticulum membrane|cellular response to hydrostatic pressure|cellular response to osmotic stress|cellular response to fluid shear stress|integral component of lumenal side of endoplasmic reticulum membrane|potassium ion transmembrane transport|determination of liver left/right asymmetry|metanephric mesenchyme development|mesonephric tubule development|mesonephric duct development|metanephric smooth muscle tissue development|metanephric cortex development|metanephric ascending thin limb development|metanephric cortical collecting duct development|metanephric distal tubule development|metanephric S-shaped body morphogenesis|mitotic spindle|regulation of calcium ion import|non-motile cilium|inorganic cation transmembrane transport|cell-cell signaling by wnt|negative regulation of G1/S transition of mitotic cell cycle" PKDCC 27.72101565 9.134603715 46.30742758 5.069451179 2.341829569 0.027403264 0.732591389 0.185797371 0.982463532 91461 "protein kinase domain containing, cytoplasmic" "GO:0001501,GO:0004672,GO:0004715,GO:0005524,GO:0005576,GO:0005794,GO:0015031,GO:0018108,GO:0030154,GO:0030282,GO:0030501,GO:0032332,GO:0035108,GO:0035264,GO:0042997,GO:0048286,GO:0048566,GO:0060021" skeletal system development|protein kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding|extracellular region|Golgi apparatus|protein transport|peptidyl-tyrosine phosphorylation|cell differentiation|bone mineralization|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|limb morphogenesis|multicellular organism growth|negative regulation of Golgi to plasma membrane protein transport|lung alveolus development|embryonic digestive tract development|roof of mouth development PKDREJ 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.020329253 10343 polycystin family receptor for egg jelly "GO:0005262,GO:0005509,GO:0007340,GO:0016020,GO:0016021,GO:0050982,GO:0070588" calcium channel activity|calcium ion binding|acrosome reaction|membrane|integral component of membrane|detection of mechanical stimulus|calcium ion transmembrane transport PKHD1L1 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.008917715 0 93035 PKHD1 like 1 "GO:0005615,GO:0005829,GO:0006955,GO:0007605,GO:0016021,GO:0032426,GO:0038023,GO:0120234" extracellular space|cytosol|immune response|sensory perception of sound|integral component of membrane|stereocilium tip|signaling receptor activity|stereocilium coat PKIA 568.1083644 748.0225487 388.1941801 0.518960532 -0.946303271 0.017447697 0.571222429 8.733218817 4.727424505 5569 cAMP-dependent protein kinase inhibitor alpha "GO:0000122,GO:0004862,GO:0005515,GO:0005634,GO:0005737,GO:0010389,GO:0034236,GO:0042308,GO:2000480" negative regulation of transcription by RNA polymerase II|cAMP-dependent protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|regulation of G2/M transition of mitotic cell cycle|protein kinase A catalytic subunit binding|negative regulation of protein import into nucleus|negative regulation of cAMP-dependent protein kinase activity hsa05034 Alcoholism PKIB 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.154498744 0.089394012 5570 cAMP-dependent protein kinase inhibitor beta "GO:0004862,GO:0005634,GO:0005737,GO:0032212,GO:0051973,GO:1904355,GO:2000480" cAMP-dependent protein kinase inhibitor activity|nucleus|cytoplasm|positive regulation of telomere maintenance via telomerase|positive regulation of telomerase activity|positive regulation of telomere capping|negative regulation of cAMP-dependent protein kinase activity PKIG 650.1728239 700.3196182 600.0260297 0.856788835 -0.222988415 0.562726599 1 17.24293538 15.40993933 11142 cAMP-dependent protein kinase inhibitor gamma "GO:0000122,GO:0004862,GO:0005515,GO:0005634,GO:0005737,GO:0007165,GO:0042308,GO:2000480" negative regulation of transcription by RNA polymerase II|cAMP-dependent protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|signal transduction|negative regulation of protein import into nucleus|negative regulation of cAMP-dependent protein kinase activity PKM 81913.14254 97484.49085 66341.79422 0.68053691 -0.555254683 0.237525999 1 1471.169713 1044.312293 5315 pyruvate kinase M1/2 "GO:0000287,GO:0001666,GO:0001889,GO:0003723,GO:0003729,GO:0004743,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005739,GO:0005791,GO:0005829,GO:0005929,GO:0006096,GO:0006754,GO:0007584,GO:0009629,GO:0012501,GO:0014870,GO:0016301,GO:0023026,GO:0030955,GO:0031100,GO:0031982,GO:0032869,GO:0034774,GO:0042802,GO:0042866,GO:0043312,GO:0043403,GO:0043531,GO:0045296,GO:0061621,GO:0062023,GO:0070062,GO:0070324,GO:1902912,GO:1903561,GO:1903672,GO:1904813,GO:2000767" magnesium ion binding|response to hypoxia|liver development|RNA binding|mRNA binding|pyruvate kinase activity|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|mitochondrion|rough endoplasmic reticulum|cytosol|cilium|glycolytic process|ATP biosynthetic process|response to nutrient|response to gravity|programmed cell death|response to muscle inactivity|kinase activity|MHC class II protein complex binding|potassium ion binding|animal organ regeneration|vesicle|cellular response to insulin stimulus|secretory granule lumen|identical protein binding|pyruvate biosynthetic process|neutrophil degranulation|skeletal muscle tissue regeneration|ADP binding|cadherin binding|canonical glycolysis|collagen-containing extracellular matrix|extracellular exosome|thyroid hormone binding|pyruvate kinase complex|extracellular vesicle|positive regulation of sprouting angiogenesis|ficolin-1-rich granule lumen|positive regulation of cytoplasmic translation "hsa00010,hsa00230,hsa00620,hsa04922,hsa04930,hsa05165,hsa05203,hsa05230" Glycolysis / Gluconeogenesis|Purine metabolism|Pyruvate metabolism|Glucagon signaling pathway|Type II diabetes mellitus|Human papillomavirus infection|Viral carcinogenesis|Central carbon metabolism in cancer PKMYT1 592.2421455 444.5507141 739.9335768 1.664452566 0.735047757 0.061458481 1 8.959381373 15.55483384 9088 "protein kinase, membrane associated tyrosine/threonine 1" "GO:0000079,GO:0000086,GO:0000139,GO:0000278,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006468,GO:0007088,GO:0010923,GO:0016020,GO:0016301,GO:0046872,GO:0051321,GO:0106310,GO:0106311" regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|Golgi membrane|mitotic cell cycle|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein phosphorylation|regulation of mitotic nuclear division|negative regulation of phosphatase activity|membrane|kinase activity|metal ion binding|meiotic cell cycle|protein serine kinase activity|protein threonine kinase activity "hsa04110,hsa04114,hsa04914" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation PKN1 3958.387645 3879.161711 4037.613579 1.040846935 0.057757925 0.856807527 1 61.91801318 67.22329715 5585 protein kinase N1 "GO:0001782,GO:0001783,GO:0002634,GO:0002637,GO:0003014,GO:0003682,GO:0004672,GO:0004674,GO:0004698,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0006357,GO:0006468,GO:0006469,GO:0006972,GO:0007165,GO:0007257,GO:0010631,GO:0018105,GO:0030374,GO:0030496,GO:0030889,GO:0031267,GO:0032154,GO:0032991,GO:0035402,GO:0035407,GO:0035556,GO:0042393,GO:0042826,GO:0045893,GO:0048536,GO:0050681,GO:2000145" "B cell homeostasis|B cell apoptotic process|regulation of germinal center formation|regulation of immunoglobulin production|renal system process|chromatin binding|protein kinase activity|protein serine/threonine kinase activity|calcium-dependent protein kinase C activity|protein kinase C binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|regulation of transcription by RNA polymerase II|protein phosphorylation|negative regulation of protein kinase activity|hyperosmotic response|signal transduction|activation of JUN kinase activity|epithelial cell migration|peptidyl-serine phosphorylation|nuclear receptor coactivator activity|midbody|negative regulation of B cell proliferation|small GTPase binding|cleavage furrow|protein-containing complex|histone kinase activity (H3-T11 specific)|histone H3-T11 phosphorylation|intracellular signal transduction|histone binding|histone deacetylase binding|positive regulation of transcription, DNA-templated|spleen development|androgen receptor binding|regulation of cell motility" "hsa04151,hsa04621,hsa05132,hsa05135" PI3K-Akt signaling pathway|NOD-like receptor signaling pathway|Salmonella infection|Yersinia infection PKN2 1652.675908 1845.189951 1460.161865 0.791334174 -0.337641033 0.303137469 1 12.40902424 10.24267715 5586 protein kinase N2 "GO:0003723,GO:0004672,GO:0004674,GO:0004698,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0007049,GO:0007155,GO:0007165,GO:0010631,GO:0016032,GO:0016301,GO:0016604,GO:0018105,GO:0030027,GO:0030030,GO:0030496,GO:0032154,GO:0032467,GO:0032991,GO:0035556,GO:0042826,GO:0043296,GO:0043297,GO:0045070,GO:0045111,GO:0045296,GO:0045931,GO:0048471,GO:0051301,GO:0070063,GO:2000145" RNA binding|protein kinase activity|protein serine/threonine kinase activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|plasma membrane|protein phosphorylation|apoptotic process|cell cycle|cell adhesion|signal transduction|epithelial cell migration|viral process|kinase activity|nuclear body|peptidyl-serine phosphorylation|lamellipodium|cell projection organization|midbody|cleavage furrow|positive regulation of cytokinesis|protein-containing complex|intracellular signal transduction|histone deacetylase binding|apical junction complex|apical junction assembly|positive regulation of viral genome replication|intermediate filament cytoskeleton|cadherin binding|positive regulation of mitotic cell cycle|perinuclear region of cytoplasm|cell division|RNA polymerase binding|regulation of cell motility "hsa04151,hsa04621,hsa05135" PI3K-Akt signaling pathway|NOD-like receptor signaling pathway|Yersinia infection PKN3 1648.592082 1397.594368 1899.589795 1.359185353 0.442742211 0.177186217 1 14.83925039 21.03810307 29941 protein kinase N3 "GO:0004672,GO:0004674,GO:0004698,GO:0005515,GO:0005524,GO:0005634,GO:0005794,GO:0006468,GO:0007165,GO:0010631,GO:0018105,GO:0035556,GO:0048471" protein kinase activity|protein serine/threonine kinase activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|nucleus|Golgi apparatus|protein phosphorylation|signal transduction|epithelial cell migration|peptidyl-serine phosphorylation|intracellular signal transduction|perinuclear region of cytoplasm hsa04151 PI3K-Akt signaling pathway PKNOX1 557.275899 681.0354548 433.5163433 0.636554735 -0.651643524 0.1018229 1 6.507932686 4.321104157 5316 PBX/knotted 1 homeobox 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001525,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0006366,GO:0030217,GO:0030218,GO:0043010,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|angiogenesis|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|T cell differentiation|erythrocyte differentiation|camera-type eye development|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" PKNOX2 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.037617199 63876 PBX/knotted 1 homeobox 2 "GO:0000978,GO:0000981,GO:0003785,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0015629,GO:0015630,GO:0045171,GO:0051015,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|actin monomer binding|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|actin cytoskeleton|microtubule cytoskeleton|intercellular bridge|actin filament binding|sequence-specific double-stranded DNA binding" PKP2 230.1765236 210.0958855 250.2571618 1.191156891 0.252363448 0.628214198 1 2.439948504 3.03155574 5318 plakophilin 2 "GO:0001533,GO:0002159,GO:0002934,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005882,GO:0005886,GO:0005911,GO:0005912,GO:0007043,GO:0007507,GO:0010765,GO:0014704,GO:0016021,GO:0017080,GO:0019215,GO:0030054,GO:0030057,GO:0031424,GO:0044325,GO:0045110,GO:0045294,GO:0045296,GO:0048496,GO:0055010,GO:0060090,GO:0070268,GO:0072659,GO:0086002,GO:0086005,GO:0086019,GO:0086064,GO:0086073,GO:0086083,GO:0086091,GO:0098609,GO:0098911,GO:1990124" cornified envelope|desmosome assembly|desmosome organization|protein kinase C binding|protein binding|nucleus|nucleoplasm|cytoplasm|intermediate filament|plasma membrane|cell-cell junction|adherens junction|cell-cell junction assembly|heart development|positive regulation of sodium ion transport|intercalated disc|integral component of membrane|sodium channel regulator activity|intermediate filament binding|cell junction|desmosome|keratinization|ion channel binding|intermediate filament bundle assembly|alpha-catenin binding|cadherin binding|maintenance of animal organ identity|ventricular cardiac muscle tissue morphogenesis|molecular adaptor activity|cornification|protein localization to plasma membrane|cardiac muscle cell action potential involved in contraction|ventricular cardiac muscle cell action potential|cell-cell signaling involved in cardiac conduction|cell communication by electrical coupling involved in cardiac conduction|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential|messenger ribonucleoprotein complex hsa05412 Arrhythmogenic right ventricular cardiomyopathy PKP3 610.6219543 589.6894176 631.554491 1.070995124 0.098951912 0.802722512 1 10.19306782 11.38697421 11187 plakophilin 3 "GO:0001533,GO:0002159,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0005911,GO:0005912,GO:0006417,GO:0007043,GO:0010628,GO:0019899,GO:0030054,GO:0030057,GO:0031424,GO:0045182,GO:0045294,GO:0045296,GO:0050839,GO:0070268,GO:0072659,GO:0098609,GO:0098641,GO:1902373,GO:1990124" cornified envelope|desmosome assembly|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|cell-cell junction|adherens junction|regulation of translation|cell-cell junction assembly|positive regulation of gene expression|enzyme binding|cell junction|desmosome|keratinization|translation regulator activity|alpha-catenin binding|cadherin binding|cell adhesion molecule binding|cornification|protein localization to plasma membrane|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|negative regulation of mRNA catabolic process|messenger ribonucleoprotein complex PKP4 1279.278754 1071.793503 1486.764005 1.387173929 0.47214869 0.163655129 1 5.761868151 8.337006956 8502 plakophilin 4 "GO:0000922,GO:0001533,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0005886,GO:0005911,GO:0005912,GO:0007043,GO:0007267,GO:0009898,GO:0030054,GO:0030057,GO:0030155,GO:0030496,GO:0031424,GO:0032467,GO:0043547,GO:0044291,GO:0045296,GO:0048471,GO:0051233,GO:0070268,GO:0072686,GO:0098609" spindle pole|cornified envelope|protein binding|nucleus|cytoplasm|cytoskeleton|plasma membrane|cell-cell junction|adherens junction|cell-cell junction assembly|cell-cell signaling|cytoplasmic side of plasma membrane|cell junction|desmosome|regulation of cell adhesion|midbody|keratinization|positive regulation of cytokinesis|positive regulation of GTPase activity|cell-cell contact zone|cadherin binding|perinuclear region of cytoplasm|spindle midzone|cornification|mitotic spindle|cell-cell adhesion PLA2G12A 387.4880178 423.2366388 351.7393967 0.831070291 -0.266957591 0.543856731 1 4.10719346 3.560400449 81579 phospholipase A2 group XIIA "GO:0004623,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0006654,GO:0008150,GO:0016042,GO:0036148,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0047498,GO:0050482,GO:0102567,GO:0102568" "phospholipase A2 activity|calcium ion binding|protein binding|extracellular region|cytoplasm|phosphatidic acid biosynthetic process|biological_process|lipid catabolic process|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|calcium-dependent phospholipase A2 activity|arachidonic acid secretion|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04972,hsa04975" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Pancreatic secretion|Fat digestion and absorption PLA2G15 530.5834474 506.4630282 554.7038665 1.095250464 0.131260825 0.747651252 1 9.174022062 10.48067263 23659 phospholipase A2 group XV "GO:0004622,GO:0004806,GO:0005543,GO:0005576,GO:0005615,GO:0005654,GO:0005764,GO:0006629,GO:0006644,GO:0006650,GO:0006651,GO:0006658,GO:0006672,GO:0008270,GO:0008374,GO:0008970,GO:0009062,GO:0016020,GO:0016411,GO:0034638,GO:0043231,GO:0046338,GO:0046470,GO:0046471,GO:0047499,GO:0052739,GO:0052740,GO:0070062,GO:0102545,GO:0102567,GO:0102568" "lysophospholipase activity|triglyceride lipase activity|phospholipid binding|extracellular region|extracellular space|nucleoplasm|lysosome|lipid metabolic process|phospholipid metabolic process|glycerophospholipid metabolic process|diacylglycerol biosynthetic process|phosphatidylserine metabolic process|ceramide metabolic process|zinc ion binding|O-acyltransferase activity|phospholipase A1 activity|fatty acid catabolic process|membrane|acylglycerol O-acyltransferase activity|phosphatidylcholine catabolic process|intracellular membrane-bounded organelle|phosphatidylethanolamine catabolic process|phosphatidylcholine metabolic process|phosphatidylglycerol metabolic process|calcium-independent phospholipase A2 activity|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|extracellular exosome|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" "hsa00564,hsa04142" Glycerophospholipid metabolism|Lysosome PLA2G4A 234.6141729 345.0850292 124.1433165 0.359747036 -1.474945294 0.004567357 0.250631422 5.75859616 2.16087566 5321 phospholipase A2 group IVA "GO:0000139,GO:0001516,GO:0002827,GO:0004622,GO:0004623,GO:0005509,GO:0005544,GO:0005634,GO:0005635,GO:0005737,GO:0005743,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006071,GO:0006640,GO:0006644,GO:0006654,GO:0006663,GO:0006690,GO:0008374,GO:0010314,GO:0010572,GO:0019369,GO:0019370,GO:0032266,GO:0032308,GO:0034478,GO:0034638,GO:0035965,GO:0036148,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0042127,GO:0043032,GO:0043231,GO:0046475,GO:0047498,GO:0047499,GO:0050482,GO:0070273,GO:0071236,GO:0102545,GO:0102567,GO:0102568,GO:1902387" "Golgi membrane|prostaglandin biosynthetic process|positive regulation of T-helper 1 type immune response|lysophospholipase activity|phospholipase A2 activity|calcium ion binding|calcium-dependent phospholipid binding|nucleus|nuclear envelope|cytoplasm|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|glycerol metabolic process|monoacylglycerol biosynthetic process|phospholipid metabolic process|phosphatidic acid biosynthetic process|platelet activating factor biosynthetic process|icosanoid metabolic process|O-acyltransferase activity|phosphatidylinositol-5-phosphate binding|positive regulation of platelet activation|arachidonic acid metabolic process|leukotriene biosynthetic process|phosphatidylinositol-3-phosphate binding|positive regulation of prostaglandin secretion|phosphatidylglycerol catabolic process|phosphatidylcholine catabolic process|cardiolipin acyl-chain remodeling|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|regulation of cell population proliferation|positive regulation of macrophage activation|intracellular membrane-bounded organelle|glycerophospholipid catabolic process|calcium-dependent phospholipase A2 activity|calcium-independent phospholipase A2 activity|arachidonic acid secretion|phosphatidylinositol-4-phosphate binding|cellular response to antibiotic|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|ceramide 1-phosphate binding" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04666,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G4B 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.133467201 0.07722502 100137049 phospholipase A2 group IVB "GO:0004622,GO:0004623,GO:0005509,GO:0005544,GO:0005576,GO:0005743,GO:0005829,GO:0006644,GO:0006654,GO:0006954,GO:0007567,GO:0019369,GO:0019722,GO:0031901,GO:0036148,GO:0036150,GO:0036151,GO:0036152,GO:0036498,GO:0046475,GO:0047498,GO:0102545,GO:0102567,GO:0102568" "lysophospholipase activity|phospholipase A2 activity|calcium ion binding|calcium-dependent phospholipid binding|extracellular region|mitochondrial inner membrane|cytosol|phospholipid metabolic process|phosphatidic acid biosynthetic process|inflammatory response|parturition|arachidonic acid metabolic process|calcium-mediated signaling|early endosome membrane|phosphatidylglycerol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|IRE1-mediated unfolded protein response|glycerophospholipid catabolic process|calcium-dependent phospholipase A2 activity|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04666,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G4C 25.97317345 24.35894324 27.58740366 1.132536966 0.17955814 0.897900199 1 0.307041947 0.362715427 8605 phospholipase A2 group IVC "GO:0004622,GO:0004623,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005635,GO:0005654,GO:0005789,GO:0005811,GO:0005829,GO:0005886,GO:0006644,GO:0006663,GO:0006954,GO:0007567,GO:0008374,GO:0008970,GO:0016020,GO:0016032,GO:0019369,GO:0031966,GO:0035556,GO:0036149,GO:0036151,GO:0036152,GO:0046475,GO:0047498,GO:0047499,GO:0102545,GO:0102567,GO:0102568,GO:0140042" "lysophospholipase activity|phospholipase A2 activity|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|nuclear envelope|nucleoplasm|endoplasmic reticulum membrane|lipid droplet|cytosol|plasma membrane|phospholipid metabolic process|platelet activating factor biosynthetic process|inflammatory response|parturition|O-acyltransferase activity|phospholipase A1 activity|membrane|viral process|arachidonic acid metabolic process|mitochondrial membrane|intracellular signal transduction|phosphatidylinositol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|glycerophospholipid catabolic process|calcium-dependent phospholipase A2 activity|calcium-independent phospholipase A2 activity|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|lipid droplet formation" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04666,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G6 146.9986309 181.6771183 112.3201435 0.61824045 -0.693760044 0.245379418 1 2.682596246 1.729930514 8398 phospholipase A2 group VI "GO:0003847,GO:0004622,GO:0004623,GO:0005515,GO:0005516,GO:0005615,GO:0005739,GO:0005829,GO:0005886,GO:0006935,GO:0016021,GO:0016290,GO:0016787,GO:0019731,GO:0031143,GO:0032049,GO:0034451,GO:0034638,GO:0035774,GO:0035965,GO:0036151,GO:0036152,GO:0038096,GO:0042802,GO:0046338,GO:0046469,GO:0046473,GO:0047499,GO:0102545,GO:0102567,GO:0102568,GO:0102991" "1-alkyl-2-acetylglycerophosphocholine esterase activity|lysophospholipase activity|phospholipase A2 activity|protein binding|calmodulin binding|extracellular space|mitochondrion|cytosol|plasma membrane|chemotaxis|integral component of membrane|palmitoyl-CoA hydrolase activity|hydrolase activity|antibacterial humoral response|pseudopodium|cardiolipin biosynthetic process|centriolar satellite|phosphatidylcholine catabolic process|positive regulation of insulin secretion involved in cellular response to glucose stimulus|cardiolipin acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|phosphatidylethanolamine catabolic process|platelet activating factor metabolic process|phosphatidic acid metabolic process|calcium-independent phospholipase A2 activity|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|myristoyl-CoA hydrolase activity" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04666,hsa04750" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Fc gamma R-mediated phagocytosis|Inflammatory mediator regulation of TRP channels PLA2G7 85.24689877 102.5105528 67.98324474 0.663182891 -0.592521307 0.409860688 1 1.35520696 0.937464577 7941 phospholipase A2 group VII "GO:0003847,GO:0005543,GO:0005576,GO:0005737,GO:0016788,GO:0034362,GO:0034364,GO:0034374,GO:0034440,GO:0034441,GO:0034638,GO:0046469,GO:0047499,GO:0050729,GO:0062234,GO:0090026" "1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding|extracellular region|cytoplasm|hydrolase activity, acting on ester bonds|low-density lipoprotein particle|high-density lipoprotein particle|low-density lipoprotein particle remodeling|lipid oxidation|plasma lipoprotein particle oxidation|phosphatidylcholine catabolic process|platelet activating factor metabolic process|calcium-independent phospholipase A2 activity|positive regulation of inflammatory response|platelet activating factor catabolic process|positive regulation of monocyte chemotaxis" hsa00565 Ether lipid metabolism PLA2R1 782.62334 796.7404352 768.5062449 0.964562875 -0.052052811 0.891110065 1 2.542344526 2.557884179 22925 phospholipase A2 receptor 1 "GO:0001816,GO:0005576,GO:0005886,GO:0006898,GO:0009986,GO:0016021,GO:0030246,GO:0038023,GO:0043235,GO:0043274,GO:0043517,GO:0072593,GO:0090238,GO:0090399,GO:0090403,GO:1900138,GO:1900139,GO:1904635" "cytokine production|extracellular region|plasma membrane|receptor-mediated endocytosis|cell surface|integral component of membrane|carbohydrate binding|signaling receptor activity|receptor complex|phospholipase binding|positive regulation of DNA damage response, signal transduction by p53 class mediator|reactive oxygen species metabolic process|positive regulation of arachidonic acid secretion|replicative senescence|oxidative stress-induced premature senescence|negative regulation of phospholipase A2 activity|negative regulation of arachidonic acid secretion|positive regulation of glomerular visceral epithelial cell apoptotic process" "hsa04145,hsa05152" Phagosome|Tuberculosis PLAA 1391.610775 1476.760934 1306.460616 0.884679833 -0.176772659 0.598270328 1 12.01489664 11.08720547 9373 phospholipase A2 activating protein "GO:0005515,GO:0005634,GO:0005737,GO:0006644,GO:0006693,GO:0006954,GO:0007165,GO:0007399,GO:0010992,GO:0016005,GO:0016236,GO:0032430,GO:0043130,GO:0043161,GO:0043162,GO:0045202,GO:0070062,GO:0071222,GO:1900045,GO:1903423,GO:1903861,GO:2001224" protein binding|nucleus|cytoplasm|phospholipid metabolic process|prostaglandin metabolic process|inflammatory response|signal transduction|nervous system development|ubiquitin recycling|phospholipase A2 activator activity|macroautophagy|positive regulation of phospholipase A2 activity|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|synapse|extracellular exosome|cellular response to lipopolysaccharide|negative regulation of protein K63-linked ubiquitination|positive regulation of synaptic vesicle recycling|positive regulation of dendrite extension|positive regulation of neuron migration hsa04141 Protein processing in endoplasmic reticulum PLAAT3 483.6091976 629.2727004 337.9456949 0.537041722 -0.89689392 0.030182088 0.776258092 23.3997374 13.10795496 11145 phospholipase A and acyltransferase 3 "GO:0004623,GO:0005515,GO:0005575,GO:0005737,GO:0005777,GO:0005778,GO:0005783,GO:0005829,GO:0005886,GO:0006641,GO:0006644,GO:0007031,GO:0008654,GO:0008970,GO:0009617,GO:0016021,GO:0016032,GO:0016042,GO:0016410,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0045786,GO:0046485,GO:0048471,GO:0052739,GO:0052740,GO:0070292,GO:0102567,GO:0102568,GO:1904177" "phospholipase A2 activity|protein binding|cellular_component|cytoplasm|peroxisome|peroxisomal membrane|endoplasmic reticulum|cytosol|plasma membrane|triglyceride metabolic process|phospholipid metabolic process|peroxisome organization|phospholipid biosynthetic process|phospholipase A1 activity|response to bacterium|integral component of membrane|viral process|lipid catabolic process|N-acyltransferase activity|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|negative regulation of cell cycle|ether lipid metabolic process|perinuclear region of cytoplasm|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|N-acylphosphatidylethanolamine metabolic process|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|regulation of adipose tissue development" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04923" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Regulation of lipolysis in adipocytes PLAAT4 27.54014473 30.44867905 24.63161041 0.808954975 -0.305868687 0.790174891 1 2.034456698 1.716677563 5920 phospholipase A and acyltransferase 4 "GO:0004623,GO:0005515,GO:0005737,GO:0005829,GO:0006644,GO:0008285,GO:0008970,GO:0016020,GO:0016021,GO:0016042,GO:0016410,GO:0036152,GO:0045618,GO:0052739,GO:0052740,GO:0070292,GO:0102567,GO:0102568,GO:0150074" "phospholipase A2 activity|protein binding|cytoplasm|cytosol|phospholipid metabolic process|negative regulation of cell population proliferation|phospholipase A1 activity|membrane|integral component of membrane|lipid catabolic process|N-acyltransferase activity|phosphatidylethanolamine acyl-chain remodeling|positive regulation of keratinocyte differentiation|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|N-acylphosphatidylethanolamine metabolic process|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|positive regulation of protein-glutamine gamma-glutamyltransferase activity" PLAC1 12.95689517 10.14955968 15.76423066 1.553193553 0.635237624 0.652496694 1 0.321475543 0.520822151 10761 placenta enriched 1 "GO:0001890,GO:0003674,GO:0005575,GO:0005576" placenta development|molecular_function|cellular_component|extracellular region PLAC8 13.01627828 14.20938356 11.823173 0.832067975 -0.265226703 0.893085452 1 0.214630227 0.186279739 51316 placenta associated 8 "GO:0003682,GO:0005576,GO:0008284,GO:0009409,GO:0035578,GO:0040015,GO:0042742,GO:0043066,GO:0043312,GO:0045944,GO:0050873,GO:0120162" chromatin binding|extracellular region|positive regulation of cell population proliferation|response to cold|azurophil granule lumen|negative regulation of multicellular organism growth|defense response to bacterium|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of transcription by RNA polymerase II|brown fat cell differentiation|positive regulation of cold-induced thermogenesis PLAC8L1 6.030352707 8.119647747 3.941057666 0.485372985 -1.042834281 0.589955466 1 0.153559191 0.077744083 153770 PLAC8 like 1 PLAG1 601.1716299 415.1169911 787.2262688 1.896396162 0.923260379 0.018748677 0.589604582 2.807345594 5.553168821 5324 PLAG1 zinc finger "GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005654,GO:0005813,GO:0005829,GO:0006351,GO:0006355,GO:0010629,GO:0016607,GO:0022612,GO:0035264,GO:0045944,GO:0046872,GO:0060252,GO:0060736" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleoplasm|centrosome|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of gene expression|nuclear speck|gland morphogenesis|multicellular organism growth|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of glial cell proliferation|prostate gland growth" zf-C2H2 PLAGL2 1819.045301 1734.55975 1903.530853 1.097414403 0.134108416 0.680455879 1 13.2005007 15.1104358 5326 PLAG1 like zinc finger 2 "GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006351,GO:0006357,GO:0006629,GO:0009791,GO:0034378,GO:0043565,GO:0045944,GO:0046872,GO:2001244" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|transcription, DNA-templated|regulation of transcription by RNA polymerase II|lipid metabolic process|post-embryonic development|chylomicron assembly|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of intrinsic apoptotic signaling pathway" PLAT 1522.062063 2110.093458 934.0306669 0.442648956 -1.175765075 0.000444337 0.050609609 34.90162955 16.11465748 5327 "plasminogen activator, tissue type" "GO:0004252,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0006464,GO:0006508,GO:0007596,GO:0009986,GO:0014909,GO:0031639,GO:0042730,GO:0045861,GO:0048008,GO:0051219,GO:0062023,GO:0070062" serine-type endopeptidase activity|signaling receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|cellular protein modification process|proteolysis|blood coagulation|cell surface|smooth muscle cell migration|plasminogen activation|fibrinolysis|negative regulation of proteolysis|platelet-derived growth factor receptor signaling pathway|phosphoprotein binding|collagen-containing extracellular matrix|extracellular exosome "hsa04371,hsa04610,hsa05202,hsa05215,hsa05418" Apelin signaling pathway|Complement and coagulation cascades|Transcriptional misregulation in cancer|Prostate cancer|Fluid shear stress and atherosclerosis PLAU 12177.75342 10230.75616 14124.75068 1.380616491 0.465312622 0.175124229 1 210.9738223 303.8208383 5328 "plasminogen activator, urokinase" "GO:0001666,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0005925,GO:0006508,GO:0006935,GO:0007165,GO:0007596,GO:0009986,GO:0010469,GO:0014909,GO:0014910,GO:0030335,GO:0031639,GO:0033628,GO:0035579,GO:0042127,GO:0042730,GO:0043312,GO:0061041,GO:0070062,GO:0070821,GO:2000097" response to hypoxia|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|plasma membrane|focal adhesion|proteolysis|chemotaxis|signal transduction|blood coagulation|cell surface|regulation of signaling receptor activity|smooth muscle cell migration|regulation of smooth muscle cell migration|positive regulation of cell migration|plasminogen activation|regulation of cell adhesion mediated by integrin|specific granule membrane|regulation of cell population proliferation|fibrinolysis|neutrophil degranulation|regulation of wound healing|extracellular exosome|tertiary granule membrane|regulation of smooth muscle cell-matrix adhesion "hsa04064,hsa04610,hsa05202,hsa05205,hsa05206,hsa05215" NF-kappa B signaling pathway|Complement and coagulation cascades|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Prostate cancer PLAUR 1414.934473 1589.421046 1240.4479 0.780440087 -0.357640211 0.284424053 1 25.61201682 20.84967439 5329 "plasminogen activator, urokinase receptor" "GO:0001934,GO:0005102,GO:0005515,GO:0005576,GO:0005788,GO:0005789,GO:0005886,GO:0005887,GO:0005925,GO:0006935,GO:0007165,GO:0007596,GO:0009986,GO:0016021,GO:0019898,GO:0019899,GO:0019904,GO:0030162,GO:0030377,GO:0031225,GO:0034112,GO:0035579,GO:0038023,GO:0038195,GO:0042730,GO:0043066,GO:0043312,GO:0043388,GO:0045742,GO:0071438,GO:0090200,GO:2001243,GO:2001268" positive regulation of protein phosphorylation|signaling receptor binding|protein binding|extracellular region|endoplasmic reticulum lumen|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|focal adhesion|chemotaxis|signal transduction|blood coagulation|cell surface|integral component of membrane|extrinsic component of membrane|enzyme binding|protein domain specific binding|regulation of proteolysis|urokinase plasminogen activator receptor activity|anchored component of membrane|positive regulation of homotypic cell-cell adhesion|specific granule membrane|signaling receptor activity|urokinase plasminogen activator signaling pathway|fibrinolysis|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of DNA binding|positive regulation of epidermal growth factor receptor signaling pathway|invadopodium membrane|positive regulation of release of cytochrome c from mitochondria|negative regulation of intrinsic apoptotic signaling pathway|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway "hsa04610,hsa05205" Complement and coagulation cascades|Proteoglycans in cancer PLB1 10.50857991 11.16451565 9.852644165 0.882496337 -0.180337805 0.971696509 1 0.050373571 0.046369411 151056 phospholipase B1 "GO:0001523,GO:0004620,GO:0004622,GO:0004623,GO:0004806,GO:0005886,GO:0006644,GO:0016021,GO:0016324,GO:0031526,GO:0036151,GO:0042572,GO:0050253,GO:0102545,GO:0102567,GO:0102568,GO:2000344" "retinoid metabolic process|phospholipase activity|lysophospholipase activity|phospholipase A2 activity|triglyceride lipase activity|plasma membrane|phospholipid metabolic process|integral component of membrane|apical plasma membrane|brush border membrane|phosphatidylcholine acyl-chain remodeling|retinol metabolic process|retinyl-palmitate esterase activity|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|positive regulation of acrosome reaction" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04977" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Vitamin digestion and absorption PLBD1 67.1261491 76.12169763 58.13060058 0.763653497 -0.389009922 0.623747959 1 1.966987471 1.566801101 79887 phospholipase B domain containing 1 "GO:0004620,GO:0005576,GO:0005615,GO:0005764,GO:0005829,GO:0006644,GO:0009395,GO:0036149,GO:0036151,GO:0036152" phospholipase activity|extracellular region|extracellular space|lysosome|cytosol|phospholipid metabolic process|phospholipid catabolic process|phosphatidylinositol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling PLBD2 2183.129949 2107.04859 2259.211307 1.072216045 0.10059563 0.754564835 1 21.54544274 24.09648271 196463 phospholipase B domain containing 2 "GO:0004620,GO:0005515,GO:0005576,GO:0009395,GO:0043202,GO:0070062" phospholipase activity|protein binding|extracellular region|phospholipid catabolic process|lysosomal lumen|extracellular exosome PLCB1 63.45503701 60.8973581 66.01271591 1.083999667 0.116364314 0.902018975 1 0.428009486 0.483947747 23236 phospholipase C beta 1 "GO:0000086,GO:0000785,GO:0004435,GO:0004629,GO:0005096,GO:0005509,GO:0005515,GO:0005516,GO:0005521,GO:0005546,GO:0005634,GO:0005737,GO:0005829,GO:0007165,GO:0007186,GO:0007213,GO:0007215,GO:0007223,GO:0007613,GO:0008277,GO:0016042,GO:0016607,GO:0019899,GO:0021987,GO:0031965,GO:0032735,GO:0032991,GO:0035722,GO:0035723,GO:0040019,GO:0042802,GO:0043547,GO:0043647,GO:0045444,GO:0045663,GO:0045892,GO:0045893,GO:0046330,GO:0046488,GO:0048009,GO:0048015,GO:0048639,GO:0060466,GO:0070062,GO:0070498,GO:0080154,GO:0098794,GO:0098978,GO:0098982,GO:0099170,GO:0099178,GO:1900087,GO:1903140,GO:2000344,GO:2000438,GO:2000560" "G2/M transition of mitotic cell cycle|chromatin|phosphatidylinositol phospholipase C activity|phospholipase C activity|GTPase activator activity|calcium ion binding|protein binding|calmodulin binding|lamin binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytoplasm|cytosol|signal transduction|G protein-coupled receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|glutamate receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|memory|regulation of G protein-coupled receptor signaling pathway|lipid catabolic process|nuclear speck|enzyme binding|cerebral cortex development|nuclear membrane|positive regulation of interleukin-12 production|protein-containing complex|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|positive regulation of embryonic development|identical protein binding|positive regulation of GTPase activity|inositol phosphate metabolic process|fat cell differentiation|positive regulation of myoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|phosphatidylinositol metabolic process|insulin-like growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of developmental growth|activation of meiosis involved in egg activation|extracellular exosome|interleukin-1-mediated signaling pathway|regulation of fertilization|postsynapse|glutamatergic synapse|GABA-ergic synapse|postsynaptic modulation of chemical synaptic transmission|regulation of retrograde trans-synaptic signaling by endocanabinoid|positive regulation of G1/S transition of mitotic cell cycle|regulation of establishment of endothelial barrier|positive regulation of acrosome reaction|negative regulation of monocyte extravasation|positive regulation of CD24 production" "hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04929,hsa04933,hsa04934,hsa04935,hsa04961,hsa04970,hsa04971,hsa04972,hsa04973,hsa05010,hsa05016,hsa05017,hsa05022,hsa05131,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200" "Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Alzheimer disease|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Chagas disease|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer" PLCB2 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.008276274 0.041901194 5330 phospholipase C beta 2 "GO:0004435,GO:0004629,GO:0005509,GO:0005515,GO:0005829,GO:0006644,GO:0007186,GO:0007202,GO:0007223,GO:0016042,GO:0043647,GO:0046488,GO:0048015,GO:0050913" "phosphatidylinositol phospholipase C activity|phospholipase C activity|calcium ion binding|protein binding|cytosol|phospholipid metabolic process|G protein-coupled receptor signaling pathway|activation of phospholipase C activity|Wnt signaling pathway, calcium modulating pathway|lipid catabolic process|inositol phosphate metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol-mediated signaling|sensory perception of bitter taste" "hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04929,hsa04933,hsa04934,hsa04935,hsa04961,hsa04970,hsa04971,hsa04972,hsa04973,hsa05010,hsa05016,hsa05017,hsa05022,hsa05131,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200" "Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Alzheimer disease|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Chagas disease|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer" PLCB3 2461.082394 2249.142426 2673.022362 1.188462914 0.249096885 0.435302669 1 21.48861146 26.63850927 5331 phospholipase C beta 3 "GO:0003073,GO:0004435,GO:0004629,GO:0005509,GO:0005515,GO:0005516,GO:0005634,GO:0005829,GO:0007186,GO:0007223,GO:0016020,GO:0016042,GO:0032991,GO:0043647,GO:0045296,GO:0046488,GO:0048015,GO:0099524" "regulation of systemic arterial blood pressure|phosphatidylinositol phospholipase C activity|phospholipase C activity|calcium ion binding|protein binding|calmodulin binding|nucleus|cytosol|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|membrane|lipid catabolic process|protein-containing complex|inositol phosphate metabolic process|cadherin binding|phosphatidylinositol metabolic process|phosphatidylinositol-mediated signaling|postsynaptic cytosol" "hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04929,hsa04933,hsa04934,hsa04935,hsa04961,hsa04970,hsa04971,hsa04972,hsa04973,hsa05010,hsa05016,hsa05017,hsa05022,hsa05131,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200" "Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Alzheimer disease|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Chagas disease|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer" PLCB4 461.7579528 583.5996818 339.9162237 0.582447582 -0.779799875 0.062083032 1 2.986487326 1.814401736 5332 phospholipase C beta 4 "GO:0004435,GO:0004629,GO:0005509,GO:0005515,GO:0005634,GO:0005790,GO:0005829,GO:0007186,GO:0014069,GO:0016042,GO:0030425,GO:0043647,GO:0048015,GO:0050804,GO:0098688,GO:0098978" phosphatidylinositol phospholipase C activity|phospholipase C activity|calcium ion binding|protein binding|nucleus|smooth endoplasmic reticulum|cytosol|G protein-coupled receptor signaling pathway|postsynaptic density|lipid catabolic process|dendrite|inositol phosphate metabolic process|phosphatidylinositol-mediated signaling|modulation of chemical synaptic transmission|parallel fiber to Purkinje cell synapse|glutamatergic synapse "hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04929,hsa04933,hsa04934,hsa04935,hsa04961,hsa04970,hsa04971,hsa04972,hsa04973,hsa05010,hsa05016,hsa05017,hsa05022,hsa05131,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200" "Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Alzheimer disease|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Chagas disease|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer" PLCD1 574.2562456 595.7791534 552.7333377 0.927748704 -0.108194014 0.787512975 1 9.822302194 9.505163197 5333 phospholipase C delta 1 "GO:0001786,GO:0004435,GO:0005509,GO:0005515,GO:0005546,GO:0005737,GO:0005886,GO:0006644,GO:0016042,GO:0032794,GO:0043647,GO:0046488,GO:0048015,GO:0070062,GO:0070300" "phosphatidylserine binding|phosphatidylinositol phospholipase C activity|calcium ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|plasma membrane|phospholipid metabolic process|lipid catabolic process|GTPase activating protein binding|inositol phosphate metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol-mediated signaling|extracellular exosome|phosphatidic acid binding" "hsa00562,hsa04020,hsa04070,hsa04919,hsa04933,hsa05131" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Shigellosis PLCD3 1329.010112 1373.235425 1284.784799 0.935589612 -0.096052251 0.777157937 1 10.94406449 10.68021424 113026 phospholipase C delta 3 "GO:0001525,GO:0004435,GO:0005829,GO:0005886,GO:0016042,GO:0032154,GO:0042127,GO:0043647,GO:0046872,GO:0048015,GO:0060716" angiogenesis|phosphatidylinositol phospholipase C activity|cytosol|plasma membrane|lipid catabolic process|cleavage furrow|regulation of cell population proliferation|inositol phosphate metabolic process|metal ion binding|phosphatidylinositol-mediated signaling|labyrinthine layer blood vessel development "hsa00562,hsa04020,hsa04070,hsa04919,hsa04933,hsa05131" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Shigellosis PLCD4 10.88244591 3.044867905 18.72002391 6.148057813 2.620130731 0.073693188 1 0.034163008 0.219083653 84812 phospholipase C delta 4 "GO:0004435,GO:0005085,GO:0005509,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0007340,GO:0016042,GO:0043647,GO:0046488,GO:0048015,GO:0050790" phosphatidylinositol phospholipase C activity|guanyl-nucleotide exchange factor activity|calcium ion binding|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|acrosome reaction|lipid catabolic process|inositol phosphate metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol-mediated signaling|regulation of catalytic activity "hsa00562,hsa04020,hsa04070,hsa04919,hsa04933,hsa05131" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Shigellosis PLCE1 59.56123827 30.44867905 88.67379749 2.912237912 1.542128219 0.058356476 1 0.112423867 0.341508328 51196 phospholipase C epsilon 1 "GO:0000139,GO:0000187,GO:0001558,GO:0004435,GO:0004629,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0006651,GO:0006940,GO:0007010,GO:0007173,GO:0007200,GO:0007204,GO:0007265,GO:0007507,GO:0008277,GO:0010592,GO:0016042,GO:0019722,GO:0019899,GO:0030027,GO:0031267,GO:0032835,GO:0043647,GO:0045859,GO:0046578,GO:0046872,GO:0048015,GO:0048016" Golgi membrane|activation of MAPK activity|regulation of cell growth|phosphatidylinositol phospholipase C activity|phospholipase C activity|guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|diacylglycerol biosynthetic process|regulation of smooth muscle contraction|cytoskeleton organization|epidermal growth factor receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|Ras protein signal transduction|heart development|regulation of G protein-coupled receptor signaling pathway|positive regulation of lamellipodium assembly|lipid catabolic process|calcium-mediated signaling|enzyme binding|lamellipodium|small GTPase binding|glomerulus development|inositol phosphate metabolic process|regulation of protein kinase activity|regulation of Ras protein signal transduction|metal ion binding|phosphatidylinositol-mediated signaling|inositol phosphate-mediated signaling "hsa00562,hsa04014,hsa04015,hsa04020,hsa04024,hsa04070,hsa04919,hsa04933,hsa05131,hsa05205" Inositol phosphate metabolism|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Shigellosis|Proteoglycans in cancer PLCG1 5995.597261 5945.612063 6045.58246 1.016814147 0.024056008 0.941385923 1 55.70186388 59.07819765 5335 phospholipase C gamma 1 "GO:0001701,GO:0001726,GO:0004435,GO:0004629,GO:0005168,GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0007165,GO:0007173,GO:0007202,GO:0007411,GO:0008180,GO:0009395,GO:0010634,GO:0010863,GO:0016032,GO:0016477,GO:0019722,GO:0019901,GO:0030027,GO:0030971,GO:0035254,GO:0038095,GO:0038096,GO:0042995,GO:0043536,GO:0043647,GO:0045766,GO:0046488,GO:0050429,GO:0050804,GO:0050852,GO:0050900,GO:0051281,GO:0071364,GO:0098685,GO:0098978,GO:1905564,GO:2000353" in utero embryonic development|ruffle|phosphatidylinositol phospholipase C activity|phospholipase C activity|neurotrophin TRKA receptor binding|calcium ion binding|protein binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|signal transduction|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|axon guidance|COP9 signalosome|phospholipid catabolic process|positive regulation of epithelial cell migration|positive regulation of phospholipase C activity|viral process|cell migration|calcium-mediated signaling|protein kinase binding|lamellipodium|receptor tyrosine kinase binding|glutamate receptor binding|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|cell projection|positive regulation of blood vessel endothelial cell migration|inositol phosphate metabolic process|positive regulation of angiogenesis|phosphatidylinositol metabolic process|calcium-dependent phospholipase C activity|modulation of chemical synaptic transmission|T cell receptor signaling pathway|leukocyte migration|positive regulation of release of sequestered calcium ion into cytosol|cellular response to epidermal growth factor stimulus|Schaffer collateral - CA1 synapse|glutamatergic synapse|positive regulation of vascular endothelial cell proliferation|positive regulation of endothelial cell apoptotic process "hsa00562,hsa01521,hsa04012,hsa04014,hsa04015,hsa04020,hsa04062,hsa04064,hsa04066,hsa04070,hsa04072,hsa04360,hsa04370,hsa04650,hsa04658,hsa04659,hsa04660,hsa04664,hsa04666,hsa04670,hsa04722,hsa04750,hsa04919,hsa04933,hsa04935,hsa05012,hsa05022,hsa05110,hsa05120,hsa05131,hsa05135,hsa05167,hsa05170,hsa05171,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225,hsa05231,hsa05235" "Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Axon guidance|VEGF signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Yersinia infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" PLCG2 61.91503567 90.33108119 33.49899016 0.370846775 -1.431104871 0.0740745 1 0.527919524 0.204210543 5336 phospholipase C gamma 2 "GO:0001784,GO:0002092,GO:0002223,GO:0002316,GO:0004435,GO:0004629,GO:0005515,GO:0005829,GO:0005886,GO:0006661,GO:0009395,GO:0010634,GO:0016055,GO:0019722,GO:0030168,GO:0030183,GO:0032237,GO:0032481,GO:0032496,GO:0032959,GO:0038095,GO:0038096,GO:0043069,GO:0043647,GO:0050852,GO:0050853,GO:0051209,GO:0070062,GO:0140031" phosphotyrosine residue binding|positive regulation of receptor internalization|stimulatory C-type lectin receptor signaling pathway|follicular B cell differentiation|phosphatidylinositol phospholipase C activity|phospholipase C activity|protein binding|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|phospholipid catabolic process|positive regulation of epithelial cell migration|Wnt signaling pathway|calcium-mediated signaling|platelet activation|B cell differentiation|activation of store-operated calcium channel activity|positive regulation of type I interferon production|response to lipopolysaccharide|inositol trisphosphate biosynthetic process|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|negative regulation of programmed cell death|inositol phosphate metabolic process|T cell receptor signaling pathway|B cell receptor signaling pathway|release of sequestered calcium ion into cytosol|extracellular exosome|phosphorylation-dependent protein binding "hsa00562,hsa01521,hsa04012,hsa04014,hsa04020,hsa04062,hsa04064,hsa04066,hsa04070,hsa04072,hsa04360,hsa04370,hsa04380,hsa04611,hsa04625,hsa04650,hsa04662,hsa04664,hsa04666,hsa04670,hsa04722,hsa04750,hsa04919,hsa04933,hsa04935,hsa05110,hsa05120,hsa05131,hsa05167,hsa05169,hsa05170,hsa05171,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225" "Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Ras signaling pathway|Calcium signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Platelet activation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma" PLCH1 37.64516709 47.70293051 27.58740366 0.578316748 -0.790068211 0.397388931 1 0.19545224 0.117902321 23007 phospholipase C eta 1 "GO:0004435,GO:0005509,GO:0005737,GO:0005829,GO:0005886,GO:0016042,GO:0043231,GO:0043647,GO:0048015,GO:0050429" phosphatidylinositol phospholipase C activity|calcium ion binding|cytoplasm|cytosol|plasma membrane|lipid catabolic process|intracellular membrane-bounded organelle|inositol phosphate metabolic process|phosphatidylinositol-mediated signaling|calcium-dependent phospholipase C activity hsa00562 Inositol phosphate metabolism PLCH2 6.567522243 11.16451565 1.970528833 0.176499267 -2.5022659 0.161860904 1 0.078730623 0.014494476 9651 phospholipase C eta 2 "GO:0004435,GO:0005509,GO:0005575,GO:0005737,GO:0005886,GO:0016042,GO:0043647,GO:0046488,GO:0048015" phosphatidylinositol phospholipase C activity|calcium ion binding|cellular_component|cytoplasm|plasma membrane|lipid catabolic process|inositol phosphate metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol-mediated signaling hsa00562 Inositol phosphate metabolism PLCL1 25.91379035 20.29911937 31.52846133 1.553193553 0.635237624 0.551953704 1 0.163368629 0.264673326 5334 phospholipase C like 1 (inactive) "GO:0004435,GO:0004629,GO:0005737,GO:0005886,GO:0006629,GO:0007214,GO:0032228,GO:0033135,GO:0035556,GO:0048015,GO:0050811,GO:0070679,GO:0120163,GO:1900122" "phosphatidylinositol phospholipase C activity|phospholipase C activity|cytoplasm|plasma membrane|lipid metabolic process|gamma-aminobutyric acid signaling pathway|regulation of synaptic transmission, GABAergic|regulation of peptidyl-serine phosphorylation|intracellular signal transduction|phosphatidylinositol-mediated signaling|GABA receptor binding|inositol 1,4,5 trisphosphate binding|negative regulation of cold-induced thermogenesis|positive regulation of receptor binding" hsa04727 GABAergic synapse PLCL2 180.0940635 187.7668541 172.4212729 0.918273215 -0.12300463 0.83397683 1 0.696734469 0.667352271 23228 phospholipase C like 2 "GO:0002322,GO:0002337,GO:0004435,GO:0005515,GO:0005737,GO:0006629,GO:0007214,GO:0032228,GO:0033135,GO:0048015,GO:0050811,GO:0050859,GO:0070679,GO:0120163,GO:1900122" "B cell proliferation involved in immune response|B-1a B cell differentiation|phosphatidylinositol phospholipase C activity|protein binding|cytoplasm|lipid metabolic process|gamma-aminobutyric acid signaling pathway|regulation of synaptic transmission, GABAergic|regulation of peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|GABA receptor binding|negative regulation of B cell receptor signaling pathway|inositol 1,4,5 trisphosphate binding|negative regulation of cold-induced thermogenesis|positive regulation of receptor binding" PLCXD1-2 9.49362394 9.134603715 9.852644165 1.078606634 0.109168812 1 1 0.228574829 0.25716237 55344 phosphatidylinositol specific phospholipase C X domain containing 1 PLCXD2 51.42402314 46.68797455 56.16007174 1.202880877 0.266493777 0.768264946 1 1.100829239 1.38120616 257068 phosphatidylinositol specific phospholipase C X domain containing 2 "GO:0005634,GO:0007165,GO:0008081,GO:0016042" nucleus|signal transduction|phosphoric diester hydrolase activity|lipid catabolic process PLCXD3 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.00571663 0.017365324 345557 phosphatidylinositol specific phospholipase C X domain containing 3 "GO:0005515,GO:0005737,GO:0007165,GO:0008081,GO:0016042" protein binding|cytoplasm|signal transduction|phosphoric diester hydrolase activity|lipid catabolic process PLD1 855.939186 757.1571524 954.7212196 1.260928747 0.334486754 0.356515517 1 5.444744949 7.161170543 5337 phospholipase D1 "GO:0000139,GO:0004630,GO:0005515,GO:0005765,GO:0005768,GO:0005789,GO:0005794,GO:0005886,GO:0006654,GO:0006935,GO:0007264,GO:0007265,GO:0016020,GO:0016042,GO:0016324,GO:0030139,GO:0031902,GO:0032534,GO:0035091,GO:0035579,GO:0043312,GO:0045727,GO:0048017,GO:0048471,GO:0048870,GO:0070290,GO:0070821,GO:0098693,GO:0098981" Golgi membrane|phospholipase D activity|protein binding|lysosomal membrane|endosome|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|phosphatidic acid biosynthetic process|chemotaxis|small GTPase mediated signal transduction|Ras protein signal transduction|membrane|lipid catabolic process|apical plasma membrane|endocytic vesicle|late endosome membrane|regulation of microvillus assembly|phosphatidylinositol binding|specific granule membrane|neutrophil degranulation|positive regulation of translation|inositol lipid-mediated signaling|perinuclear region of cytoplasm|cell motility|N-acylphosphatidylethanolamine-specific phospholipase D activity|tertiary granule membrane|regulation of synaptic vesicle cycle|cholinergic synapse "hsa00564,hsa00565,hsa04014,hsa04024,hsa04071,hsa04072,hsa04144,hsa04666,hsa04724,hsa04912,hsa04928,hsa05200,hsa05212,hsa05231" "Glycerophospholipid metabolism|Ether lipid metabolism|Ras signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Pancreatic cancer|Choline metabolism in cancer" PLD2 1187.758526 1011.9111 1363.605953 1.347555088 0.430344252 0.209237804 1 14.65953302 20.60547328 5338 phospholipase D2 "GO:0004630,GO:0005515,GO:0005789,GO:0005886,GO:0006654,GO:0007010,GO:0007264,GO:0016042,GO:0035091,GO:0036465,GO:0038096,GO:0048017,GO:0048870,GO:0070290,GO:0098793" phospholipase D activity|protein binding|endoplasmic reticulum membrane|plasma membrane|phosphatidic acid biosynthetic process|cytoskeleton organization|small GTPase mediated signal transduction|lipid catabolic process|phosphatidylinositol binding|synaptic vesicle recycling|Fc-gamma receptor signaling pathway involved in phagocytosis|inositol lipid-mediated signaling|cell motility|N-acylphosphatidylethanolamine-specific phospholipase D activity|presynapse "hsa00564,hsa00565,hsa04014,hsa04024,hsa04071,hsa04072,hsa04144,hsa04666,hsa04724,hsa04912,hsa04928,hsa05200,hsa05212,hsa05231" "Glycerophospholipid metabolism|Ether lipid metabolism|Ras signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Pancreatic cancer|Choline metabolism in cancer" PLD3 1973.691237 1866.504026 2080.878448 1.114853447 0.156854074 0.627397025 1 36.08085659 41.95759151 23646 phospholipase D family member 3 "GO:0000139,GO:0002376,GO:0004630,GO:0005515,GO:0005765,GO:0005789,GO:0006259,GO:0006954,GO:0014902,GO:0016021,GO:0031901,GO:0031902,GO:0043202,GO:0045145,GO:0070062,GO:0090305,GO:1900015" Golgi membrane|immune system process|phospholipase D activity|protein binding|lysosomal membrane|endoplasmic reticulum membrane|DNA metabolic process|inflammatory response|myotube differentiation|integral component of membrane|early endosome membrane|late endosome membrane|lysosomal lumen|single-stranded DNA 5'-3' exodeoxyribonuclease activity|extracellular exosome|nucleic acid phosphodiester bond hydrolysis|regulation of cytokine production involved in inflammatory response "hsa00564,hsa00565" Glycerophospholipid metabolism|Ether lipid metabolism PLD6 63.78164408 83.22638941 44.33689874 0.532726447 -0.90853319 0.248834141 1 1.336013635 0.74238823 201164 phospholipase D family member 6 "GO:0004519,GO:0005515,GO:0005741,GO:0006654,GO:0007286,GO:0008053,GO:0010636,GO:0016021,GO:0016042,GO:0030719,GO:0034587,GO:0035755,GO:0042803,GO:0043046,GO:0046872,GO:0051321,GO:0090305" endonuclease activity|protein binding|mitochondrial outer membrane|phosphatidic acid biosynthetic process|spermatid development|mitochondrial fusion|positive regulation of mitochondrial fusion|integral component of membrane|lipid catabolic process|P granule organization|piRNA metabolic process|cardiolipin hydrolase activity|protein homodimerization activity|DNA methylation involved in gamete generation|metal ion binding|meiotic cell cycle|nucleic acid phosphodiester bond hydrolysis PLEC 16643.44759 17234.9673 16051.92787 0.931358186 -0.102591983 0.772540666 1 51.9577555 50.47578102 5339 plectin "GO:0003723,GO:0003779,GO:0005198,GO:0005200,GO:0005515,GO:0005737,GO:0005829,GO:0005882,GO:0005886,GO:0005903,GO:0005925,GO:0008307,GO:0016020,GO:0016528,GO:0030056,GO:0030506,GO:0031581,GO:0042060,GO:0042383,GO:0043034,GO:0045104,GO:0045111,GO:0045296,GO:0048471,GO:0070062" RNA binding|actin binding|structural molecule activity|structural constituent of cytoskeleton|protein binding|cytoplasm|cytosol|intermediate filament|plasma membrane|brush border|focal adhesion|structural constituent of muscle|membrane|sarcoplasm|hemidesmosome|ankyrin binding|hemidesmosome assembly|wound healing|sarcolemma|costamere|intermediate filament cytoskeleton organization|intermediate filament cytoskeleton|cadherin binding|perinuclear region of cytoplasm|extracellular exosome PLEK2 907.9988559 880.9817805 935.0159313 1.061334016 0.085878763 0.813146012 1 29.49016475 32.64714531 26499 pleckstrin 2 "GO:0005737,GO:0005856,GO:0005886,GO:0031258,GO:0031532,GO:0032266,GO:0035556,GO:0043325,GO:0080025,GO:0120034" "cytoplasm|cytoskeleton|plasma membrane|lamellipodium membrane|actin cytoskeleton reorganization|phosphatidylinositol-3-phosphate binding|intracellular signal transduction|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|positive regulation of plasma membrane bounded cell projection assembly" PLEKHA1 382.9382833 381.6234441 384.2531225 1.006890767 0.009907181 0.988736962 1 2.731855994 2.869168741 59338 pleckstrin homology domain containing A1 "GO:0001553,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0007283,GO:0008209,GO:0008210,GO:0008289,GO:0009791,GO:0014065,GO:0016020,GO:0030165,GO:0031529,GO:0032587,GO:0033327,GO:0035264,GO:0043325,GO:0045184,GO:0048008,GO:0048705,GO:0050853,GO:0051898,GO:0060021,GO:0060325,GO:0070062,GO:0070301" "luteinization|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|spermatogenesis|androgen metabolic process|estrogen metabolic process|lipid binding|post-embryonic development|phosphatidylinositol 3-kinase signaling|membrane|PDZ domain binding|ruffle organization|ruffle membrane|Leydig cell differentiation|multicellular organism growth|phosphatidylinositol-3,4-bisphosphate binding|establishment of protein localization|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|B cell receptor signaling pathway|negative regulation of protein kinase B signaling|roof of mouth development|face morphogenesis|extracellular exosome|cellular response to hydrogen peroxide" PLEKHA2 418.9098371 449.625494 388.1941801 0.863372263 -0.21194535 0.623144251 1 3.945243432 3.552939622 59339 pleckstrin homology domain containing A2 "GO:0001954,GO:0001968,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0006661,GO:0008289,GO:0016020,GO:0030165,GO:0032991,GO:0043236,GO:0043325" "positive regulation of cell-matrix adhesion|fibronectin binding|protein binding|nucleus|cytoplasm|plasma membrane|phosphatidylinositol biosynthetic process|lipid binding|membrane|PDZ domain binding|protein-containing complex|laminin binding|phosphatidylinositol-3,4-bisphosphate binding" PLEKHA3 379.848878 372.4888404 387.2089157 1.039518165 0.055914968 0.904808081 1 1.353123347 1.467186762 65977 pleckstrin homology domain containing A3 "GO:0000139,GO:0005515,GO:0005794,GO:0005829,GO:0006661,GO:0008150,GO:0016020,GO:0035627,GO:0042802,GO:0070273,GO:0120009,GO:1902387,GO:1902388,GO:1902389" Golgi membrane|protein binding|Golgi apparatus|cytosol|phosphatidylinositol biosynthetic process|biological_process|membrane|ceramide transport|identical protein binding|phosphatidylinositol-4-phosphate binding|intermembrane lipid transfer|ceramide 1-phosphate binding|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport PLEKHA4 28.95865825 26.38885518 31.52846133 1.194764271 0.256726001 0.826006297 1 0.413905983 0.515822 57664 pleckstrin homology domain containing A4 "GO:0005546,GO:0005737,GO:0005886,GO:0006661,GO:0031234,GO:0032266,GO:0043325,GO:0080025,GO:0090263,GO:2000096" "phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|plasma membrane|phosphatidylinositol biosynthetic process|extrinsic component of cytoplasmic side of plasma membrane|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|positive regulation of canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway" PLEKHA5 1427.150564 1346.84657 1507.454557 1.119247426 0.162529001 0.627060418 1 5.366456406 6.265123552 54477 pleckstrin homology domain containing A5 "GO:0005515,GO:0005654,GO:0005829,GO:0008150,GO:0010314,GO:0014069,GO:0016020,GO:0032266,GO:0061458,GO:0070273,GO:0080025,GO:0098978" "protein binding|nucleoplasm|cytosol|biological_process|phosphatidylinositol-5-phosphate binding|postsynaptic density|membrane|phosphatidylinositol-3-phosphate binding|reproductive system development|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-3,5-bisphosphate binding|glutamatergic synapse" PLEKHA6 781.1941862 564.3155184 998.072854 1.768643288 0.822643105 0.026415473 0.720384826 1.70011244 3.136417187 22874 pleckstrin homology domain containing A6 GO:0005515 protein binding PLEKHA7 34.76632432 19.2841634 50.24848524 2.605686552 1.381663547 0.148023707 1 0.071656262 0.194756629 144100 pleckstrin homology domain containing A7 "GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0005915,GO:0030054,GO:0044331,GO:0045218,GO:0046930,GO:0046931,GO:0070062,GO:0070097,GO:0090136" protein binding|nucleoplasm|centrosome|cytosol|zonula adherens|cell junction|cell-cell adhesion mediated by cadherin|zonula adherens maintenance|pore complex|pore complex assembly|extracellular exosome|delta-catenin binding|epithelial cell-cell adhesion PLEKHA8 857.8488479 955.0735662 760.6241296 0.796403708 -0.328428157 0.365070871 1 3.138128119 2.606872997 84725 pleckstrin homology domain containing A8 "GO:0000139,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0006661,GO:0006869,GO:0015031,GO:0016020,GO:0017089,GO:0035621,GO:0035627,GO:0046836,GO:0051861,GO:0070273,GO:0097001,GO:0120009,GO:1902387,GO:1902388,GO:1902389" Golgi membrane|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|phosphatidylinositol biosynthetic process|lipid transport|protein transport|membrane|glycolipid transfer activity|ER to Golgi ceramide transport|ceramide transport|glycolipid transport|glycolipid binding|phosphatidylinositol-4-phosphate binding|ceramide binding|intermembrane lipid transfer|ceramide 1-phosphate binding|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport PLEKHB1 203.1559811 215.1706653 191.1412968 0.888324143 -0.170841894 0.756597737 1 3.516500523 3.258352617 58473 pleckstrin homology domain containing B1 "GO:0005515,GO:0005737,GO:0007275,GO:0007602,GO:0016021,GO:0045595" protein binding|cytoplasm|multicellular organism development|phototransduction|integral component of membrane|regulation of cell differentiation PLEKHB2 2508.140275 2199.409583 2816.870967 1.280739608 0.356977185 0.263336098 1 22.07974952 29.49652895 55041 pleckstrin homology domain containing B2 "GO:0005515,GO:0005547,GO:0016021,GO:0045595,GO:0055038" "protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|integral component of membrane|regulation of cell differentiation|recycling endosome membrane" PLEKHF1 110.4008329 104.5404647 116.2612012 1.112116743 0.153308241 0.826855736 1 1.551305521 1.799548877 79156 pleckstrin homology and FYVE domain containing 1 "GO:0005515,GO:0005634,GO:0005764,GO:0005765,GO:0005768,GO:0006915,GO:0007032,GO:0010008,GO:0010314,GO:0010508,GO:0016050,GO:0032266,GO:0035091,GO:0046872,GO:0048471,GO:0070273,GO:0072659,GO:2001244" protein binding|nucleus|lysosome|lysosomal membrane|endosome|apoptotic process|endosome organization|endosome membrane|phosphatidylinositol-5-phosphate binding|positive regulation of autophagy|vesicle organization|phosphatidylinositol-3-phosphate binding|phosphatidylinositol binding|metal ion binding|perinuclear region of cytoplasm|phosphatidylinositol-4-phosphate binding|protein localization to plasma membrane|positive regulation of intrinsic apoptotic signaling pathway PLEKHF2 424.7647621 412.0721232 437.4574009 1.061603968 0.086245668 0.844559441 1 7.194070781 7.966236017 79666 pleckstrin homology and FYVE domain containing 2 "GO:0005515,GO:0005783,GO:0015031,GO:0030133,GO:0031901,GO:0035091,GO:0046872" protein binding|endoplasmic reticulum|protein transport|transport vesicle|early endosome membrane|phosphatidylinositol binding|metal ion binding PLEKHG1 18.00198346 18.26920743 17.7347595 0.970745971 -0.042834281 1 1 0.122390332 0.123927771 57480 pleckstrin homology and RhoGEF domain containing G1 "GO:0005654,GO:0050790" nucleoplasm|regulation of catalytic activity PLEKHG2 1272.970291 1179.378835 1366.561746 1.158713133 0.212523438 0.531383152 1 7.140630891 8.630350695 64857 pleckstrin homology and RhoGEF domain containing G2 "GO:0005515,GO:0005829,GO:0007186,GO:0030833,GO:0043065,GO:0050790,GO:0051056" protein binding|cytosol|G protein-coupled receptor signaling pathway|regulation of actin filament polymerization|positive regulation of apoptotic process|regulation of catalytic activity|regulation of small GTPase mediated signal transduction PLEKHG3 1071.456747 1143.855376 999.0581184 0.873412967 -0.195264144 0.575989105 1 6.384421372 5.816438065 26030 pleckstrin homology and RhoGEF domain containing G3 GO:0050790 regulation of catalytic activity PLEKHG5 1364.90224 1132.690861 1597.113619 1.410017221 0.495712782 0.140026068 1 9.401310423 13.82702472 57449 pleckstrin homology and RhoGEF domain containing G5 "GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0007186,GO:0007266,GO:0030027,GO:0030139,GO:0030424,GO:0035767,GO:0043065,GO:0043123,GO:0043542,GO:0048471,GO:0050790,GO:0051056" cytoplasm|cytosol|plasma membrane|cell-cell junction|G protein-coupled receptor signaling pathway|Rho protein signal transduction|lamellipodium|endocytic vesicle|axon|endothelial cell chemotaxis|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|endothelial cell migration|perinuclear region of cytoplasm|regulation of catalytic activity|regulation of small GTPase mediated signal transduction hsa05200 Pathways in cancer PLEKHH1 496.8199548 454.7002738 538.9396359 1.185263495 0.245207819 0.550818424 1 2.848004549 3.521044527 57475 "pleckstrin homology, MyTH4 and FERM domain containing H1" GO:0005856 cytoskeleton PLEKHH2 327.9134176 189.7967661 466.030069 2.455416278 1.295967632 0.005386264 0.28256493 1.290793157 3.305960915 130271 "pleckstrin homology, MyTH4 and FERM domain containing H2" "GO:0003779,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0016604,GO:0030027,GO:0030835,GO:0030864,GO:0042802" actin binding|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|nuclear body|lamellipodium|negative regulation of actin filament depolymerization|cortical actin cytoskeleton|identical protein binding PLEKHH3 693.3665979 622.1680086 764.5651872 1.22887255 0.297335297 0.432773704 1 9.070412999 11.62652246 79990 "pleckstrin homology, MyTH4 and FERM domain containing H3" "GO:0005615,GO:0005856,GO:0007165" extracellular space|cytoskeleton|signal transduction PLEKHJ1 566.0853795 474.9993932 657.1713658 1.383520432 0.46834395 0.23758158 1 11.83327278 17.07679572 55111 pleckstrin homology domain containing J1 "GO:0001881,GO:0005515,GO:0005769,GO:0005802,GO:0005829,GO:0007032,GO:0042147,GO:0055037" "receptor recycling|protein binding|early endosome|trans-Golgi network|cytosol|endosome organization|retrograde transport, endosome to Golgi|recycling endosome" PLEKHM1 900.9265773 835.308762 966.5443926 1.157110325 0.210526425 0.558686754 1 6.505526988 7.851871459 9842 pleckstrin homology and RUN domain containing M1 "GO:0005730,GO:0005765,GO:0006914,GO:0010008,GO:0015031,GO:0032418,GO:0035556,GO:0043231,GO:0045780,GO:0046872,GO:1900029" nucleolus|lysosomal membrane|autophagy|endosome membrane|protein transport|lysosome localization|intracellular signal transduction|intracellular membrane-bounded organelle|positive regulation of bone resorption|metal ion binding|positive regulation of ruffle assembly hsa05132 Salmonella infection PLEKHM2 2051.768617 2017.732465 2085.80477 1.033737032 0.047869231 0.883087477 1 22.77998913 24.56289302 23207 pleckstrin homology and RUN domain containing M2 "GO:0005515,GO:0007030,GO:0010008,GO:0019894,GO:0032418,GO:0032880,GO:1903527" protein binding|Golgi organization|endosome membrane|kinesin binding|lysosome localization|regulation of protein localization|positive regulation of membrane tubulation hsa05132 Salmonella infection PLEKHM3 259.1230577 201.9762377 316.2698777 1.565876666 0.646970585 0.192137756 1 0.566693475 0.925596479 389072 pleckstrin homology domain containing M3 "GO:0005737,GO:0005794,GO:0005886,GO:0045445,GO:0046872" cytoplasm|Golgi apparatus|plasma membrane|myoblast differentiation|metal ion binding PLEKHN1 167.6770595 147.1686154 188.1855036 1.278706761 0.354685457 0.538145479 1 1.923998759 2.566206961 84069 pleckstrin homology domain containing N1 "GO:0001666,GO:0001786,GO:0005515,GO:0005739,GO:0005856,GO:0005886,GO:0031966,GO:0043065,GO:0061158,GO:0070300,GO:1901612,GO:1901981" response to hypoxia|phosphatidylserine binding|protein binding|mitochondrion|cytoskeleton|plasma membrane|mitochondrial membrane|positive regulation of apoptotic process|3'-UTR-mediated mRNA destabilization|phosphatidic acid binding|cardiolipin binding|phosphatidylinositol phosphate binding PLEKHO1 505.8100602 597.8090654 413.8110549 0.692212746 -0.530712587 0.192890254 1 11.20122835 8.087628101 51177 pleckstrin homology domain containing O1 "GO:0005515,GO:0005634,GO:0005737,GO:0007520,GO:0008360,GO:0032587,GO:0036195,GO:0051451,GO:0072673" protein binding|nucleus|cytoplasm|myoblast fusion|regulation of cell shape|ruffle membrane|muscle cell projection membrane|myoblast migration|lamellipodium morphogenesis PLEKHO2 502.8530292 429.3263746 576.3796837 1.342521023 0.42494468 0.298011972 1 5.89424405 8.254012813 80301 pleckstrin homology domain containing O2 "GO:0005576,GO:0043312,GO:0071888,GO:1904813" extracellular region|neutrophil degranulation|macrophage apoptotic process|ficolin-1-rich granule lumen PLGLB1 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.047464395 0.032040421 5343 plasminogen like B1 "GO:0004252,GO:0005576,GO:0006508" serine-type endopeptidase activity|extracellular region|proteolysis PLGLB2 8.478667972 7.104691779 9.852644165 1.386779958 0.471738892 0.817532793 1 0.119306225 0.172578461 5342 plasminogen like B2 "GO:0004252,GO:0005576,GO:0006508" serine-type endopeptidase activity|extracellular region|proteolysis PLGRKT 184.0945043 191.826678 176.3623306 0.91938375 -0.121260928 0.835084309 1 5.986040985 5.740535923 55848 plasminogen receptor with a C-terminal lysine "GO:0005515,GO:0005887,GO:0006935,GO:0006954,GO:0010756" protein binding|integral component of plasma membrane|chemotaxis|inflammatory response|positive regulation of plasminogen activation PLIN1 7.986035764 7.104691779 8.867379749 1.248101962 0.319735798 0.916631795 1 0.122265571 0.159173284 5346 perilipin 1 "GO:0005783,GO:0005811,GO:0005829,GO:0006629,GO:0008289,GO:0016042" endoplasmic reticulum|lipid droplet|cytosol|lipid metabolic process|lipid binding|lipid catabolic process "hsa03320,hsa04371,hsa04714,hsa04923" PPAR signaling pathway|Apelin signaling pathway|Thermogenesis|Regulation of lipolysis in adipocytes PLIN2 1382.401696 1823.875875 940.9275178 0.515894492 -0.954852052 0.004646541 0.253948442 40.98175636 22.05298529 123 perilipin 2 "GO:0005515,GO:0005576,GO:0005634,GO:0005783,GO:0005811,GO:0005829,GO:0005886,GO:0010890,GO:0014070,GO:0015909,GO:0019216,GO:0019915,GO:0042493" protein binding|extracellular region|nucleus|endoplasmic reticulum|lipid droplet|cytosol|plasma membrane|positive regulation of sequestering of triglyceride|response to organic cyclic compound|long-chain fatty acid transport|regulation of lipid metabolic process|lipid storage|response to drug hsa03320 PPAR signaling pathway PLIN3 2047.114963 1969.014579 2125.215346 1.079329412 0.110135243 0.733026466 1 44.67905114 50.30068307 10226 perilipin 3 "GO:0005515,GO:0005737,GO:0005768,GO:0005794,GO:0005811,GO:0005829,GO:0010008,GO:0010890,GO:0016020,GO:0016192,GO:0019915,GO:0030133,GO:0045296" protein binding|cytoplasm|endosome|Golgi apparatus|lipid droplet|cytosol|endosome membrane|positive regulation of sequestering of triglyceride|membrane|vesicle-mediated transport|lipid storage|transport vesicle|cadherin binding PLIN5 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.062433934 0.084290953 440503 perilipin 5 "GO:0005515,GO:0005737,GO:0005739,GO:0005811,GO:0005829,GO:0010867,GO:0010884,GO:0010890,GO:0010897,GO:0019915,GO:0031999,GO:0032000,GO:0034389,GO:0035359,GO:0035473,GO:0042802,GO:0043231,GO:0051646,GO:0060192,GO:0060193,GO:2000378" protein binding|cytoplasm|mitochondrion|lipid droplet|cytosol|positive regulation of triglyceride biosynthetic process|positive regulation of lipid storage|positive regulation of sequestering of triglyceride|negative regulation of triglyceride catabolic process|lipid storage|negative regulation of fatty acid beta-oxidation|positive regulation of fatty acid beta-oxidation|lipid droplet organization|negative regulation of peroxisome proliferator activated receptor signaling pathway|lipase binding|identical protein binding|intracellular membrane-bounded organelle|mitochondrion localization|negative regulation of lipase activity|positive regulation of lipase activity|negative regulation of reactive oxygen species metabolic process hsa03320 PPAR signaling pathway PLK1 2297.116778 2355.712803 2238.520754 0.95025198 -0.073617969 0.818993504 1 55.23543657 54.74853516 5347 polo like kinase 1 "GO:0000070,GO:0000086,GO:0000122,GO:0000132,GO:0000278,GO:0000281,GO:0000287,GO:0000776,GO:0000785,GO:0000795,GO:0000922,GO:0000942,GO:0001578,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005876,GO:0006468,GO:0006511,GO:0007062,GO:0007077,GO:0007094,GO:0007098,GO:0007346,GO:0008017,GO:0010389,GO:0010800,GO:0010997,GO:0015630,GO:0016301,GO:0016321,GO:0016567,GO:0018105,GO:0019901,GO:0030071,GO:0030496,GO:0031145,GO:0031648,GO:0032436,GO:0032465,GO:0034451,GO:0042802,GO:0043066,GO:0043393,GO:0045143,GO:0045184,GO:0045736,GO:0045862,GO:0051081,GO:0051233,GO:0051443,GO:0051726,GO:0070194,GO:0071168,GO:0072425,GO:0090435,GO:0097431,GO:0097711,GO:1900182,GO:1901673,GO:1901990,GO:1902749,GO:1904668,GO:1904776" mitotic sister chromatid segregation|G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|establishment of mitotic spindle orientation|mitotic cell cycle|mitotic cytokinesis|magnesium ion binding|kinetochore|chromatin|synaptonemal complex|spindle pole|condensed nuclear chromosome outer kinetochore|microtubule bundle formation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|centriole|spindle|cytosol|spindle microtubule|protein phosphorylation|ubiquitin-dependent protein catabolic process|sister chromatid cohesion|mitotic nuclear envelope disassembly|mitotic spindle assembly checkpoint|centrosome cycle|regulation of mitotic cell cycle|microtubule binding|regulation of G2/M transition of mitotic cell cycle|positive regulation of peptidyl-threonine phosphorylation|anaphase-promoting complex binding|microtubule cytoskeleton|kinase activity|female meiosis chromosome segregation|protein ubiquitination|peptidyl-serine phosphorylation|protein kinase binding|regulation of mitotic metaphase/anaphase transition|midbody|anaphase-promoting complex-dependent catabolic process|protein destabilization|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of cytokinesis|centriolar satellite|identical protein binding|negative regulation of apoptotic process|regulation of protein binding|homologous chromosome segregation|establishment of protein localization|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of proteolysis|nuclear envelope disassembly|spindle midzone|positive regulation of ubiquitin-protein transferase activity|regulation of cell cycle|synaptonemal complex disassembly|protein localization to chromatin|signal transduction involved in G2 DNA damage checkpoint|protein localization to nuclear envelope|mitotic spindle pole|ciliary basal body-plasma membrane docking|positive regulation of protein localization to nucleus|regulation of mitotic spindle assembly|regulation of mitotic cell cycle phase transition|regulation of cell cycle G2/M phase transition|positive regulation of ubiquitin protein ligase activity|regulation of protein localization to cell cortex "hsa04068,hsa04110,hsa04114,hsa04914" FoxO signaling pathway|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation PLK2 3765.71179 3841.60834 3689.81524 0.960487096 -0.058161863 0.855723182 1 69.83629219 69.96625649 10769 polo like kinase 2 "GO:0000082,GO:0000278,GO:0000785,GO:0000922,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0006468,GO:0006977,GO:0007052,GO:0007093,GO:0007265,GO:0007613,GO:0010508,GO:0016525,GO:0018105,GO:0030425,GO:0032092,GO:0032436,GO:0032465,GO:0032486,GO:0043008,GO:0043066,GO:0043123,GO:0044877,GO:0045732,GO:0046599,GO:0048167,GO:0060291,GO:0060292,GO:0061000,GO:0071866,GO:0090050,GO:2000773" "G1/S transition of mitotic cell cycle|mitotic cell cycle|chromatin|spindle pole|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|centriole|cytosol|protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|mitotic spindle organization|mitotic cell cycle checkpoint|Ras protein signal transduction|memory|positive regulation of autophagy|negative regulation of angiogenesis|peptidyl-serine phosphorylation|dendrite|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of cytokinesis|Rap protein signal transduction|ATP-dependent protein binding|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein-containing complex binding|positive regulation of protein catabolic process|regulation of centriole replication|regulation of synaptic plasticity|long-term synaptic potentiation|long-term synaptic depression|negative regulation of dendritic spine development|negative regulation of apoptotic process in bone marrow cell|positive regulation of cell migration involved in sprouting angiogenesis|negative regulation of cellular senescence" hsa04068 FoxO signaling pathway PLK3 365.6125245 308.5466144 422.6784347 1.369901386 0.454072043 0.308175112 1 6.678118603 9.542438346 1263 polo like kinase 3 "GO:0000082,GO:0000086,GO:0000122,GO:0000278,GO:0000302,GO:0000922,GO:0002039,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005795,GO:0005813,GO:0006468,GO:0006915,GO:0006970,GO:0006974,GO:0006977,GO:0007093,GO:0007113,GO:0009314,GO:0030425,GO:0031122,GO:0032465,GO:0043025,GO:0043066,GO:0043491,GO:0044819,GO:0051302,GO:0090166,GO:0090316,GO:1901796,GO:1904716,GO:2000777" "G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|mitotic cell cycle|response to reactive oxygen species|spindle pole|p53 binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi stack|centrosome|protein phosphorylation|apoptotic process|response to osmotic stress|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|mitotic cell cycle checkpoint|endomitotic cell cycle|response to radiation|dendrite|cytoplasmic microtubule organization|regulation of cytokinesis|neuronal cell body|negative regulation of apoptotic process|protein kinase B signaling|mitotic G1/S transition checkpoint|regulation of cell division|Golgi disassembly|positive regulation of intracellular protein transport|regulation of signal transduction by p53 class mediator|positive regulation of chaperone-mediated autophagy|positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia" "hsa04068,hsa04625,hsa05152" FoxO signaling pathway|C-type lectin receptor signaling pathway|Tuberculosis PLK4 767.7634639 690.1700585 845.3568694 1.224853004 0.29260862 0.430191146 1 8.396511816 10.72750696 10733 polo like kinase 4 "GO:0000086,GO:0000278,GO:0000922,GO:0001741,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0006468,GO:0007099,GO:0010389,GO:0032154,GO:0032465,GO:0042802,GO:0046601,GO:0060707,GO:0097711,GO:0098535,GO:0098536" G2/M transition of mitotic cell cycle|mitotic cell cycle|spindle pole|XY body|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleolus|cytoplasm|centrosome|centriole|cytosol|protein phosphorylation|centriole replication|regulation of G2/M transition of mitotic cell cycle|cleavage furrow|regulation of cytokinesis|identical protein binding|positive regulation of centriole replication|trophoblast giant cell differentiation|ciliary basal body-plasma membrane docking|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|deuterosome hsa04068 FoxO signaling pathway PLLP 37.61547554 45.67301858 29.5579325 0.64716398 -0.627796782 0.50545586 1 1.545208595 1.043079433 51090 plasmolipin "GO:0005515,GO:0006811,GO:0009611,GO:0016021,GO:0019911,GO:0042552,GO:0043218,GO:0045121" protein binding|ion transport|response to wounding|integral component of membrane|structural constituent of myelin sheath|myelination|compact myelin|membrane raft PLOD1 7195.923486 9736.472605 4655.374368 0.478137674 -1.064502009 0.001321802 0.108804729 158.2027556 78.90107829 5351 "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1" "GO:0001666,GO:0005506,GO:0005515,GO:0005783,GO:0005789,GO:0006493,GO:0008475,GO:0008544,GO:0017185,GO:0018215,GO:0030867,GO:0031418,GO:0033823,GO:0055114,GO:0070062,GO:1902494" response to hypoxia|iron ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein O-linked glycosylation|procollagen-lysine 5-dioxygenase activity|epidermis development|peptidyl-lysine hydroxylation|protein phosphopantetheinylation|rough endoplasmic reticulum membrane|L-ascorbic acid binding|procollagen glucosyltransferase activity|oxidation-reduction process|extracellular exosome|catalytic complex hsa00310 Lysine degradation PLOD2 3636.868305 4732.739681 2540.99693 0.536897675 -0.897280938 0.005096877 0.273055593 61.84122 34.63263228 5352 "procollagen-lysine,2-oxoglutarate 5-dioxygenase 2" "GO:0001666,GO:0005506,GO:0005783,GO:0005789,GO:0006464,GO:0006493,GO:0008475,GO:0017185,GO:0018215,GO:0030867,GO:0031418,GO:0033823,GO:0046947,GO:0055114,GO:0070062" response to hypoxia|iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|cellular protein modification process|protein O-linked glycosylation|procollagen-lysine 5-dioxygenase activity|peptidyl-lysine hydroxylation|protein phosphopantetheinylation|rough endoplasmic reticulum membrane|L-ascorbic acid binding|procollagen glucosyltransferase activity|hydroxylysine biosynthetic process|oxidation-reduction process|extracellular exosome hsa00310 Lysine degradation PLOD3 3591.768329 3468.104544 3715.432115 1.071314912 0.099382621 0.755304652 1 62.26418306 69.5779092 8985 "procollagen-lysine,2-oxoglutarate 5-dioxygenase 3" "GO:0001701,GO:0001886,GO:0005506,GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0005789,GO:0005791,GO:0005794,GO:0005802,GO:0006493,GO:0008104,GO:0008475,GO:0017185,GO:0018215,GO:0021915,GO:0030199,GO:0031418,GO:0032870,GO:0032963,GO:0033823,GO:0042311,GO:0046947,GO:0048730,GO:0050211,GO:0055114,GO:0060425,GO:0062023,GO:0070062,GO:0070831" in utero embryonic development|endothelial cell morphogenesis|iron ion binding|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|rough endoplasmic reticulum|Golgi apparatus|trans-Golgi network|protein O-linked glycosylation|protein localization|procollagen-lysine 5-dioxygenase activity|peptidyl-lysine hydroxylation|protein phosphopantetheinylation|neural tube development|collagen fibril organization|L-ascorbic acid binding|cellular response to hormone stimulus|collagen metabolic process|procollagen glucosyltransferase activity|vasodilation|hydroxylysine biosynthetic process|epidermis morphogenesis|procollagen galactosyltransferase activity|oxidation-reduction process|lung morphogenesis|collagen-containing extracellular matrix|extracellular exosome|basement membrane assembly "hsa00310,hsa00514" Lysine degradation|Other types of O-glycan biosynthesis PLP2 11019.07083 9455.329801 12582.81186 1.330763932 0.41225467 0.224972863 1 434.1605603 602.6529966 5355 proteolipid protein 2 "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006811,GO:0006935,GO:0015075,GO:0016020,GO:0016021,GO:0019221,GO:0019956,GO:0034220" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|ion transport|chemotaxis|ion transmembrane transporter activity|membrane|integral component of membrane|cytokine-mediated signaling pathway|chemokine binding|ion transmembrane transport PLPBP 721.6166183 734.8281211 708.4051155 0.964041924 -0.052832208 0.891554451 1 9.462611751 9.515308468 11212 pyridoxal phosphate binding protein "GO:0005622,GO:0005737,GO:0005829,GO:0008150,GO:0030170" intracellular anatomical structure|cytoplasm|cytosol|biological_process|pyridoxal phosphate binding PLPP1 379.4777337 347.1149412 411.8405261 1.186467297 0.246672336 0.577705437 1 10.33518355 12.79056992 8611 phospholipid phosphatase 1 "GO:0000810,GO:0005515,GO:0005886,GO:0005887,GO:0005901,GO:0006644,GO:0006670,GO:0006672,GO:0007165,GO:0007205,GO:0008195,GO:0008285,GO:0016020,GO:0016324,GO:0019216,GO:0030148,GO:0030518,GO:0030521,GO:0042392,GO:0042577,GO:0045121,GO:0046839,GO:0070062,GO:0106235" diacylglycerol diphosphate phosphatase activity|protein binding|plasma membrane|integral component of plasma membrane|caveola|phospholipid metabolic process|sphingosine metabolic process|ceramide metabolic process|signal transduction|protein kinase C-activating G protein-coupled receptor signaling pathway|phosphatidate phosphatase activity|negative regulation of cell population proliferation|membrane|apical plasma membrane|regulation of lipid metabolic process|sphingolipid biosynthetic process|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|membrane raft|phospholipid dephosphorylation|extracellular exosome|ceramide-1-phosphate phosphatase activity "hsa00561,hsa00564,hsa00565,hsa00600,hsa04072,hsa04666,hsa04975,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Sphingolipid metabolism|Phospholipase D signaling pathway|Fc gamma R-mediated phagocytosis|Fat digestion and absorption|Choline metabolism in cancer PLPP2 205.6879278 287.232539 124.1433165 0.43220492 -1.210212601 0.024658651 0.693409464 9.916370012 4.470523263 8612 phospholipid phosphatase 2 "GO:0005515,GO:0005769,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0005901,GO:0006644,GO:0006670,GO:0006672,GO:0007165,GO:0008195,GO:0016021,GO:0030148,GO:0031901,GO:0042392,GO:0042577,GO:0046839,GO:0106235,GO:1902806" protein binding|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|caveola|phospholipid metabolic process|sphingosine metabolic process|ceramide metabolic process|signal transduction|phosphatidate phosphatase activity|integral component of membrane|sphingolipid biosynthetic process|early endosome membrane|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation|ceramide-1-phosphate phosphatase activity|regulation of cell cycle G1/S phase transition "hsa00561,hsa00564,hsa00565,hsa00600,hsa04072,hsa04666,hsa04975,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Sphingolipid metabolism|Phospholipase D signaling pathway|Fc gamma R-mediated phagocytosis|Fat digestion and absorption|Choline metabolism in cancer PLPP3 1356.537887 1739.63453 973.4412435 0.559566522 -0.837618444 0.013074401 0.506315505 26.91914203 15.71190582 8613 phospholipid phosphatase 3 "GO:0000139,GO:0001933,GO:0005178,GO:0005515,GO:0005789,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0005912,GO:0006644,GO:0006670,GO:0006672,GO:0006890,GO:0007165,GO:0007229,GO:0008195,GO:0016020,GO:0016021,GO:0016323,GO:0030111,GO:0030148,GO:0033116,GO:0033631,GO:0034109,GO:0042392,GO:0042577,GO:0044328,GO:0044329,GO:0044330,GO:0045121,GO:0046839,GO:0050821,GO:0051091,GO:0060070,GO:0070971,GO:0106235" "Golgi membrane|negative regulation of protein phosphorylation|integrin binding|protein binding|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|adherens junction|phospholipid metabolic process|sphingosine metabolic process|ceramide metabolic process|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|signal transduction|integrin-mediated signaling pathway|phosphatidate phosphatase activity|membrane|integral component of membrane|basolateral plasma membrane|regulation of Wnt signaling pathway|sphingolipid biosynthetic process|endoplasmic reticulum-Golgi intermediate compartment membrane|cell-cell adhesion mediated by integrin|homotypic cell-cell adhesion|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt signaling pathway involved in positive regulation of wound healing|membrane raft|phospholipid dephosphorylation|protein stabilization|positive regulation of DNA-binding transcription factor activity|canonical Wnt signaling pathway|endoplasmic reticulum exit site|ceramide-1-phosphate phosphatase activity" "hsa00561,hsa00564,hsa00565,hsa00600,hsa04072,hsa04666,hsa04975,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Sphingolipid metabolism|Phospholipase D signaling pathway|Fc gamma R-mediated phagocytosis|Fat digestion and absorption|Choline metabolism in cancer PLPP5 425.2007328 374.5187523 475.8827132 1.27065123 0.345568092 0.418596055 1 3.954149173 5.240772894 84513 phospholipid phosphatase 5 "GO:0000810,GO:0005515,GO:0005737,GO:0005886,GO:0006644,GO:0008195,GO:0016021,GO:0046839" diacylglycerol diphosphate phosphatase activity|protein binding|cytoplasm|plasma membrane|phospholipid metabolic process|phosphatidate phosphatase activity|integral component of membrane|phospholipid dephosphorylation "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism PLPP6 162.4214087 158.3331311 166.5096864 1.051641468 0.072642936 0.910453649 1 2.704558018 2.966743058 403313 phospholipid phosphatase 6 "GO:0005515,GO:0005886,GO:0006695,GO:0016020,GO:0016021,GO:0016787,GO:0042392,GO:0042577,GO:0046839" protein binding|plasma membrane|cholesterol biosynthetic process|membrane|integral component of membrane|hydrolase activity|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation PLPP7 6.985925571 6.08973581 7.882115332 1.294327961 0.372203218 0.905012836 1 0.117182232 0.158205665 84814 phospholipid phosphatase 7 (inactive) "GO:0005635,GO:0005789,GO:0010832,GO:0016020,GO:0016021,GO:0016311,GO:0042392" nuclear envelope|endoplasmic reticulum membrane|negative regulation of myotube differentiation|membrane|integral component of membrane|dephosphorylation|sphingosine-1-phosphate phosphatase activity PLPPR2 1036.879459 1002.776497 1070.982421 1.068017075 0.094934712 0.788382171 1 18.45461191 20.55886063 64748 phospholipid phosphatase related 2 "GO:0005515,GO:0005887,GO:0006644,GO:0007165,GO:0008195,GO:0042577,GO:0046839" protein binding|integral component of plasma membrane|phospholipid metabolic process|signal transduction|phosphatidate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation PLPPR3 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.05658734 0.011459635 79948 phospholipid phosphatase related 3 "GO:0005887,GO:0006644,GO:0007165,GO:0008195,GO:0042577,GO:0046839" integral component of plasma membrane|phospholipid metabolic process|signal transduction|phosphatidate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation PLRG1 1040.357576 1004.806409 1075.908743 1.070762222 0.098638145 0.780088392 1 15.34214647 17.13543345 5356 pleiotropic regulator 1 "GO:0000398,GO:0000974,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0016607,GO:0031965,GO:0034504,GO:0071007,GO:0071013,GO:0080008,GO:1900087" "mRNA splicing, via spliceosome|Prp19 complex|fibrillar center|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|nuclear speck|nuclear membrane|protein localization to nucleus|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|Cul4-RING E3 ubiquitin ligase complex|positive regulation of G1/S transition of mitotic cell cycle" hsa03040 Spliceosome PLS1 238.4094944 301.4419226 175.3770661 0.581793881 -0.781419971 0.12536217 1 3.164794767 1.920572168 5357 plastin 1 "GO:0001951,GO:0005200,GO:0005509,GO:0005737,GO:0005884,GO:0005903,GO:0032420,GO:0032432,GO:0032532,GO:0040018,GO:0051015,GO:0051017,GO:0051639,GO:0060088,GO:0060121,GO:0070062,GO:1902896,GO:1903078,GO:1990357" intestinal D-glucose absorption|structural constituent of cytoskeleton|calcium ion binding|cytoplasm|actin filament|brush border|stereocilium|actin filament bundle|regulation of microvillus length|positive regulation of multicellular organism growth|actin filament binding|actin filament bundle assembly|actin filament network formation|auditory receptor cell stereocilium organization|vestibular receptor cell stereocilium organization|extracellular exosome|terminal web assembly|positive regulation of protein localization to plasma membrane|terminal web PLS3 5620.131847 6007.524377 5232.739316 0.871030892 -0.199204209 0.537636444 1 79.71179366 72.42225935 5358 plastin 3 "GO:0005509,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0032432,GO:0051015,GO:0051017,GO:0051639,GO:0060348" calcium ion binding|cytoplasm|cytosol|actin filament|plasma membrane|actin filament bundle|actin filament binding|actin filament bundle assembly|actin filament network formation|bone development PLSCR1 459.5662211 366.3991046 552.7333377 1.508555372 0.593167652 0.155747145 1 8.121147514 12.77893275 5359 phospholipid scramblase 1 "GO:0000287,GO:0001228,GO:0001618,GO:0003677,GO:0004518,GO:0005154,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0006659,GO:0006915,GO:0006953,GO:0008270,GO:0010288,GO:0010628,GO:0016020,GO:0017121,GO:0017124,GO:0017128,GO:0019899,GO:0030168,GO:0032791,GO:0033003,GO:0035456,GO:0042609,GO:0045071,GO:0045089,GO:0045121,GO:0045340,GO:0045944,GO:0046718,GO:0048471,GO:0050765,GO:0051607,GO:0060368,GO:0062023,GO:0070062,GO:0070782,GO:0090305,GO:1905820,GO:2000373" "magnesium ion binding|DNA-binding transcription activator activity, RNA polymerase II-specific|virus receptor activity|DNA binding|nuclease activity|epidermal growth factor receptor binding|calcium ion binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|phosphatidylserine biosynthetic process|apoptotic process|acute-phase response|zinc ion binding|response to lead ion|positive regulation of gene expression|membrane|plasma membrane phospholipid scrambling|SH3 domain binding|phospholipid scramblase activity|enzyme binding|platelet activation|lead ion binding|regulation of mast cell activation|response to interferon-beta|CD4 receptor binding|negative regulation of viral genome replication|positive regulation of innate immune response|membrane raft|mercury ion binding|positive regulation of transcription by RNA polymerase II|viral entry into host cell|perinuclear region of cytoplasm|negative regulation of phagocytosis|defense response to virus|regulation of Fc receptor mediated stimulatory signaling pathway|collagen-containing extracellular matrix|extracellular exosome|phosphatidylserine exposure on apoptotic cell surface|nucleic acid phosphodiester bond hydrolysis|positive regulation of chromosome separation|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity" PLSCR3 1328.934646 1199.677955 1458.191336 1.215485648 0.281532859 0.403652372 1 34.60105706 43.86873707 57048 phospholipid scramblase 3 "GO:0000287,GO:0005509,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005829,GO:0005886,GO:0006915,GO:0016021,GO:0017121,GO:0017124,GO:0017128,GO:0032049,GO:0032791,GO:0042593,GO:0042632,GO:0042981,GO:0043621,GO:0045340,GO:0048306,GO:0071222,GO:0090199" magnesium ion binding|calcium ion binding|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|cytosol|plasma membrane|apoptotic process|integral component of membrane|plasma membrane phospholipid scrambling|SH3 domain binding|phospholipid scramblase activity|cardiolipin biosynthetic process|lead ion binding|glucose homeostasis|cholesterol homeostasis|regulation of apoptotic process|protein self-association|mercury ion binding|calcium-dependent protein binding|cellular response to lipopolysaccharide|regulation of release of cytochrome c from mitochondria PLSCR4 59.82846224 48.71788648 70.93903799 1.456118956 0.542128219 0.505204783 1 0.511906449 0.77750535 57088 phospholipid scramblase 4 "GO:0005509,GO:0005515,GO:0005886,GO:0016021,GO:0017121,GO:0017124,GO:0017128,GO:0019899,GO:0042609,GO:0071222" calcium ion binding|protein binding|plasma membrane|integral component of membrane|plasma membrane phospholipid scrambling|SH3 domain binding|phospholipid scramblase activity|enzyme binding|CD4 receptor binding|cellular response to lipopolysaccharide PLTP 33.18178566 45.67301858 20.69055275 0.453014786 -1.142369955 0.236259957 1 1.147978792 0.542453071 5360 phospholipid transfer protein "GO:0005576,GO:0005615,GO:0005634,GO:0006629,GO:0006869,GO:0008035,GO:0008429,GO:0008525,GO:0008526,GO:0010189,GO:0010875,GO:0015914,GO:0015918,GO:0019992,GO:0030169,GO:0030317,GO:0031210,GO:0034189,GO:0034364,GO:0034375,GO:0035627,GO:0046836,GO:0070300,GO:0097001,GO:0120009,GO:0120014,GO:0120017,GO:0120019,GO:0120020,GO:0140337,GO:0140338,GO:0140339,GO:0140340,GO:1901611,GO:1904121,GO:1990050" extracellular region|extracellular space|nucleus|lipid metabolic process|lipid transport|high-density lipoprotein particle binding|phosphatidylethanolamine binding|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|vitamin E biosynthetic process|positive regulation of cholesterol efflux|phospholipid transport|sterol transport|diacylglycerol binding|low-density lipoprotein particle binding|flagellated sperm motility|phosphatidylcholine binding|very-low-density lipoprotein particle binding|high-density lipoprotein particle|high-density lipoprotein particle remodeling|ceramide transport|glycolipid transport|phosphatidic acid binding|ceramide binding|intermembrane lipid transfer|phospholipid transfer activity|ceramide transfer activity|phosphatidylcholine transfer activity|cholesterol transfer activity|diacylglyceride transfer activity|sphingomyelin transfer activity|phosphatidylglycerol transfer activity|cerebroside transfer activity|phosphatidylglycerol binding|phosphatidylethanolamine transfer activity|phosphatidic acid transfer activity "hsa03320,hsa04979" PPAR signaling pathway|Cholesterol metabolism PLXNA1 3629.837343 3443.745601 3815.929085 1.108075197 0.14805579 0.642072853 1 18.73601524 21.65520975 5361 plexin A1 "GO:0002116,GO:0005654,GO:0005829,GO:0005886,GO:0005887,GO:0007162,GO:0007275,GO:0008360,GO:0014910,GO:0017154,GO:0030334,GO:0038023,GO:0043087,GO:0050772,GO:0060666,GO:0070062,GO:1902287,GO:1990138" semaphorin receptor complex|nucleoplasm|cytosol|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|multicellular organism development|regulation of cell shape|regulation of smooth muscle cell migration|semaphorin receptor activity|regulation of cell migration|signaling receptor activity|regulation of GTPase activity|positive regulation of axonogenesis|dichotomous subdivision of terminal units involved in salivary gland branching|extracellular exosome|semaphorin-plexin signaling pathway involved in axon guidance|neuron projection extension hsa04360 Axon guidance PLXNA2 755.706964 438.4609783 1072.95295 2.447088801 1.291066455 0.00061127 0.067358968 1.809525893 4.618813867 5362 plexin A2 "GO:0001756,GO:0002116,GO:0005515,GO:0005886,GO:0005887,GO:0007162,GO:0008360,GO:0017154,GO:0021915,GO:0021935,GO:0030334,GO:0042802,GO:0043087,GO:0050772,GO:0051642,GO:0060037,GO:0060174,GO:0071526,GO:1902287" somitogenesis|semaphorin receptor complex|protein binding|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|regulation of cell shape|semaphorin receptor activity|neural tube development|cerebellar granule cell precursor tangential migration|regulation of cell migration|identical protein binding|regulation of GTPase activity|positive regulation of axonogenesis|centrosome localization|pharyngeal system development|limb bud formation|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance hsa04360 Axon guidance PLXNA3 2218.461896 1962.924843 2473.99895 1.260363564 0.333839953 0.297431144 1 14.72381791 19.35673957 55558 plexin A3 "GO:0002116,GO:0004888,GO:0005515,GO:0005886,GO:0005887,GO:0007162,GO:0007275,GO:0008360,GO:0016020,GO:0017154,GO:0021612,GO:0021637,GO:0021766,GO:0021785,GO:0021860,GO:0030334,GO:0043087,GO:0048843,GO:0050772,GO:0050919,GO:0051495,GO:0071526,GO:1902287,GO:1990138" semaphorin receptor complex|transmembrane signaling receptor activity|protein binding|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|multicellular organism development|regulation of cell shape|membrane|semaphorin receptor activity|facial nerve structural organization|trigeminal nerve structural organization|hippocampus development|branchiomotor neuron axon guidance|pyramidal neuron development|regulation of cell migration|regulation of GTPase activity|negative regulation of axon extension involved in axon guidance|positive regulation of axonogenesis|negative chemotaxis|positive regulation of cytoskeleton organization|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance|neuron projection extension hsa04360 Axon guidance PLXNB1 1444.273925 1338.726922 1549.820927 1.157682647 0.211239825 0.526556419 1 6.039711016 7.293258597 5364 plexin B1 "GO:0002116,GO:0004888,GO:0005096,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007162,GO:0007165,GO:0007186,GO:0008360,GO:0014068,GO:0016477,GO:0017154,GO:0030215,GO:0030334,GO:0032794,GO:0033689,GO:0035556,GO:0038023,GO:0043087,GO:0043547,GO:0043931,GO:0048812,GO:0050772,GO:0051493,GO:0071526,GO:1900220,GO:1902287,GO:1904862" semaphorin receptor complex|transmembrane signaling receptor activity|GTPase activator activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|signal transduction|G protein-coupled receptor signaling pathway|regulation of cell shape|positive regulation of phosphatidylinositol 3-kinase signaling|cell migration|semaphorin receptor activity|semaphorin receptor binding|regulation of cell migration|GTPase activating protein binding|negative regulation of osteoblast proliferation|intracellular signal transduction|signaling receptor activity|regulation of GTPase activity|positive regulation of GTPase activity|ossification involved in bone maturation|neuron projection morphogenesis|positive regulation of axonogenesis|regulation of cytoskeleton organization|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis|semaphorin-plexin signaling pathway involved in axon guidance|inhibitory synapse assembly hsa04360 Axon guidance PLXNB2 7148.393501 7328.997048 6967.789954 0.950715345 -0.072914649 0.824350372 1 50.05904859 49.64197191 23654 plexin B2 "GO:0001843,GO:0001932,GO:0002116,GO:0005515,GO:0005887,GO:0007156,GO:0007162,GO:0007405,GO:0007420,GO:0008360,GO:0009986,GO:0010976,GO:0017154,GO:0030334,GO:0043087,GO:0045727,GO:0050772,GO:0070062,GO:0071526,GO:1902287,GO:1904861,GO:2001222" neural tube closure|regulation of protein phosphorylation|semaphorin receptor complex|protein binding|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of cell adhesion|neuroblast proliferation|brain development|regulation of cell shape|cell surface|positive regulation of neuron projection development|semaphorin receptor activity|regulation of cell migration|regulation of GTPase activity|positive regulation of translation|positive regulation of axonogenesis|extracellular exosome|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance|excitatory synapse assembly|regulation of neuron migration hsa04360 Axon guidance PLXNB3 733.8230599 794.7105232 672.9355965 0.846768197 -0.23996101 0.522087908 1 6.369565506 5.625877562 5365 plexin B3 "GO:0001938,GO:0002116,GO:0005515,GO:0005886,GO:0005887,GO:0007156,GO:0007162,GO:0008360,GO:0009986,GO:0010593,GO:0010976,GO:0017154,GO:0019904,GO:0030334,GO:0030336,GO:0034260,GO:0043087,GO:0050772,GO:0050918,GO:0051022,GO:0060326,GO:0071526,GO:0098632,GO:1902287" positive regulation of endothelial cell proliferation|semaphorin receptor complex|protein binding|plasma membrane|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of cell adhesion|regulation of cell shape|cell surface|negative regulation of lamellipodium assembly|positive regulation of neuron projection development|semaphorin receptor activity|protein domain specific binding|regulation of cell migration|negative regulation of cell migration|negative regulation of GTPase activity|regulation of GTPase activity|positive regulation of axonogenesis|positive chemotaxis|Rho GDP-dissociation inhibitor binding|cell chemotaxis|semaphorin-plexin signaling pathway|cell-cell adhesion mediator activity|semaphorin-plexin signaling pathway involved in axon guidance hsa04360 Axon guidance PLXNC1 140.9143383 102.5105528 179.3181238 1.749265016 0.806748876 0.183115299 1 0.472712179 0.862518328 10154 plexin C1 "GO:0002116,GO:0005102,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007162,GO:0008360,GO:0016020,GO:0017154,GO:0030334,GO:0043087,GO:0050772,GO:1902287" semaphorin receptor complex|signaling receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|negative regulation of cell adhesion|regulation of cell shape|membrane|semaphorin receptor activity|regulation of cell migration|regulation of GTPase activity|positive regulation of axonogenesis|semaphorin-plexin signaling pathway involved in axon guidance hsa04360 Axon guidance PLXND1 1180.316341 1109.346873 1251.285809 1.1279482 0.173700815 0.613507434 1 8.129721545 9.564907091 23129 plexin D1 "GO:0001525,GO:0001569,GO:0001822,GO:0002116,GO:0003151,GO:0003279,GO:0005515,GO:0005886,GO:0005887,GO:0007162,GO:0007221,GO:0007416,GO:0008360,GO:0017154,GO:0019904,GO:0030027,GO:0030334,GO:0031258,GO:0032092,GO:0035904,GO:0043087,GO:0043542,GO:0045765,GO:0050772,GO:0060666,GO:0060976,GO:0071526,GO:1902287" angiogenesis|branching involved in blood vessel morphogenesis|kidney development|semaphorin receptor complex|outflow tract morphogenesis|cardiac septum development|protein binding|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|positive regulation of transcription of Notch receptor target|synapse assembly|regulation of cell shape|semaphorin receptor activity|protein domain specific binding|lamellipodium|regulation of cell migration|lamellipodium membrane|positive regulation of protein binding|aorta development|regulation of GTPase activity|endothelial cell migration|regulation of angiogenesis|positive regulation of axonogenesis|dichotomous subdivision of terminal units involved in salivary gland branching|coronary vasculature development|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance PM20D2 408.7184616 392.7879598 424.6489635 1.081115021 0.112520022 0.79854443 1 2.28606349 2.577959671 135293 peptidase M20 domain containing 2 "GO:0005515,GO:0005654,GO:0005737,GO:0006508,GO:0016805,GO:0032268,GO:0042802,GO:0046657,GO:0071713" protein binding|nucleoplasm|cytoplasm|proteolysis|dipeptidase activity|regulation of cellular protein metabolic process|identical protein binding|folic acid catabolic process|para-aminobenzoyl-glutamate hydrolase activity PMAIP1 1997.473916 1842.145083 2152.80275 1.168639088 0.22482945 0.485713067 1 48.66883137 59.32629901 5366 phorbol-12-myristate-13-acetate-induced protein 1 "GO:0001836,GO:0001844,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0006919,GO:0006974,GO:0010498,GO:0010907,GO:0010917,GO:0042149,GO:0042981,GO:0043029,GO:0043065,GO:0043280,GO:0043331,GO:0043517,GO:0046902,GO:0051607,GO:0071456,GO:0072332,GO:0072593,GO:0090200,GO:0097193,GO:1900740,GO:1902043,GO:1902237,GO:2001244" "release of cytochrome c from mitochondria|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|proteasomal protein catabolic process|positive regulation of glucose metabolic process|negative regulation of mitochondrial membrane potential|cellular response to glucose starvation|regulation of apoptotic process|T cell homeostasis|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to dsRNA|positive regulation of DNA damage response, signal transduction by p53 class mediator|regulation of mitochondrial membrane permeability|defense response to virus|cellular response to hypoxia|intrinsic apoptotic signaling pathway by p53 class mediator|reactive oxygen species metabolic process|positive regulation of release of cytochrome c from mitochondria|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway" "hsa01524,hsa04115,hsa04210,hsa04215,hsa05200,hsa05203,hsa05210" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Pathways in cancer|Viral carcinogenesis|Colorectal cancer PMEL 19.04663098 22.3290313 15.76423066 0.705997069 -0.5022659 0.683916782 1 0.524043866 0.385910389 6490 premelanosome protein "GO:0005515,GO:0005576,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0032438,GO:0032585,GO:0042438,GO:0042470,GO:0042802" protein binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|melanosome organization|multivesicular body membrane|melanin biosynthetic process|melanosome|identical protein binding PMEPA1 7012.69375 10108.96145 3916.426056 0.387421208 -1.368025163 4.04E-05 0.007605221 92.85151159 37.52220044 56937 "prostate transmembrane protein, androgen induced 1" "GO:0000139,GO:0005515,GO:0005886,GO:0010008,GO:0010991,GO:0016021,GO:0030512,GO:0030521,GO:0031901,GO:0043231,GO:0050699,GO:0060394,GO:0070412" Golgi membrane|protein binding|plasma membrane|endosome membrane|negative regulation of SMAD protein complex assembly|integral component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|androgen receptor signaling pathway|early endosome membrane|intracellular membrane-bounded organelle|WW domain binding|negative regulation of pathway-restricted SMAD protein phosphorylation|R-SMAD binding PMF1 224.3418876 181.6771183 267.0066569 1.46967686 0.555498983 0.285392655 1 7.456487136 11.43067979 11243 polyamine modulated factor 1 "GO:0000444,GO:0000777,GO:0000818,GO:0003713,GO:0005515,GO:0005654,GO:0005667,GO:0005794,GO:0005829,GO:0006366,GO:0007049,GO:0007059,GO:0043231,GO:0043522,GO:0045893,GO:0051301" "MIS12/MIND type complex|condensed chromosome kinetochore|nuclear MIS12/MIND complex|transcription coactivator activity|protein binding|nucleoplasm|transcription regulator complex|Golgi apparatus|cytosol|transcription by RNA polymerase II|cell cycle|chromosome segregation|intracellular membrane-bounded organelle|leucine zipper domain binding|positive regulation of transcription, DNA-templated|cell division" PMFBP1 7.971189988 6.08973581 9.852644165 1.617909951 0.694131313 0.702268135 1 0.062802614 0.105985876 83449 polyamine modulated factor 1 binding protein 1 "GO:0003674,GO:0005737,GO:0007283,GO:0097224" molecular_function|cytoplasm|spermatogenesis|sperm connecting piece PML 1478.35586 1513.299349 1443.41237 0.95381814 -0.068213874 0.838964177 1 10.96941082 10.91351901 5371 PML nuclear body scaffold "GO:0000781,GO:0000785,GO:0000792,GO:0001666,GO:0001932,GO:0003677,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006355,GO:0006606,GO:0006919,GO:0006977,GO:0007050,GO:0007179,GO:0007182,GO:0008270,GO:0008285,GO:0008630,GO:0008631,GO:0009411,GO:0010332,GO:0010522,GO:0010761,GO:0016032,GO:0016363,GO:0016525,GO:0016567,GO:0016605,GO:0030099,GO:0030155,GO:0030308,GO:0030578,GO:0031625,GO:0031901,GO:0032183,GO:0032206,GO:0032469,GO:0032691,GO:0032922,GO:0034097,GO:0042406,GO:0042752,GO:0042771,GO:0042803,GO:0043153,GO:0043161,GO:0045087,GO:0045165,GO:0045892,GO:0045893,GO:0046332,GO:0048146,GO:0048384,GO:0051457,GO:0051607,GO:0060333,GO:0060444,GO:0065003,GO:0070059,GO:0071353,GO:0090398,GO:0097191,GO:0140037,GO:1901796,GO:1902187,GO:1990830,GO:2000059,GO:2000779,GO:2001238" "chromosome, telomeric region|chromatin|heterochromatin|response to hypoxia|regulation of protein phosphorylation|DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of transcription, DNA-templated|protein import into nucleus|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell cycle arrest|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|zinc ion binding|negative regulation of cell population proliferation|intrinsic apoptotic signaling pathway in response to DNA damage|intrinsic apoptotic signaling pathway in response to oxidative stress|response to UV|response to gamma radiation|regulation of calcium ion transport into cytosol|fibroblast migration|viral process|nuclear matrix|negative regulation of angiogenesis|protein ubiquitination|PML body|myeloid cell differentiation|regulation of cell adhesion|negative regulation of cell growth|PML body organization|ubiquitin protein ligase binding|early endosome membrane|SUMO binding|positive regulation of telomere maintenance|endoplasmic reticulum calcium ion homeostasis|negative regulation of interleukin-1 beta production|circadian regulation of gene expression|response to cytokine|extrinsic component of endoplasmic reticulum membrane|regulation of circadian rhythm|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|protein homodimerization activity|entrainment of circadian clock by photoperiod|proteasome-mediated ubiquitin-dependent protein catabolic process|innate immune response|cell fate commitment|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|SMAD binding|positive regulation of fibroblast proliferation|retinoic acid receptor signaling pathway|maintenance of protein location in nucleus|defense response to virus|interferon-gamma-mediated signaling pathway|branching involved in mammary gland duct morphogenesis|protein-containing complex assembly|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to interleukin-4|cellular senescence|extrinsic apoptotic signaling pathway|sumo-dependent protein binding|regulation of signal transduction by p53 class mediator|negative regulation of viral release from host cell|cellular response to leukemia inhibitory factor|negative regulation of ubiquitin-dependent protein catabolic process|regulation of double-strand break repair|positive regulation of extrinsic apoptotic signaling pathway" "hsa04120,hsa04144,hsa05164,hsa05168,hsa05200,hsa05202,hsa05221" Ubiquitin mediated proteolysis|Endocytosis|Influenza A|Herpes simplex virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia other PMM1 1077.120161 891.1313402 1263.108982 1.417421793 0.503269136 0.14839207 1 30.74431789 45.45481531 5372 phosphomannomutase 1 "GO:0004615,GO:0005515,GO:0005829,GO:0006013,GO:0006487,GO:0009298,GO:0043025,GO:0046872,GO:1990830" phosphomannomutase activity|protein binding|cytosol|mannose metabolic process|protein N-linked glycosylation|GDP-mannose biosynthetic process|neuronal cell body|metal ion binding|cellular response to leukemia inhibitory factor "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism PMM2 661.0767966 805.8750389 516.2785543 0.640643436 -0.642406477 0.093407665 1 17.66106783 11.80182769 5373 phosphomannomutase 2 "GO:0004615,GO:0005515,GO:0005654,GO:0005829,GO:0006013,GO:0006486,GO:0006487,GO:0009298,GO:0043025,GO:0046872" phosphomannomutase activity|protein binding|nucleoplasm|cytosol|mannose metabolic process|protein glycosylation|protein N-linked glycosylation|GDP-mannose biosynthetic process|neuronal cell body|metal ion binding "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism PMP22 869.7098773 856.6228373 882.7969172 1.030554964 0.043421452 0.90749659 1 20.63983098 22.1867263 5376 peripheral myelin protein 22 "GO:0005515,GO:0005886,GO:0007268,GO:0007422,GO:0008219,GO:0016021,GO:0032060,GO:0032288,GO:0045202" protein binding|plasma membrane|chemical synaptic transmission|peripheral nervous system development|cell death|integral component of membrane|bleb assembly|myelin assembly|synapse PMPCA 1361.986779 1371.205513 1352.768044 0.986553825 -0.01953033 0.9559481 1 21.55391742 22.18007085 23203 "peptidase, mitochondrial processing subunit alpha" "GO:0005515,GO:0005615,GO:0005739,GO:0005743,GO:0005759,GO:0006627,GO:0006851,GO:0046872" protein binding|extracellular space|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|protein processing involved in protein targeting to mitochondrion|mitochondrial calcium ion transmembrane transport|metal ion binding PMPCB 1722.310001 1553.897588 1890.722415 1.216761279 0.283046147 0.386047151 1 17.6932174 22.45577892 9512 "peptidase, mitochondrial processing subunit beta" "GO:0004222,GO:0005739,GO:0005743,GO:0006627,GO:0006851,GO:0017087,GO:0046872" metalloendopeptidase activity|mitochondrion|mitochondrial inner membrane|protein processing involved in protein targeting to mitochondrion|mitochondrial calcium ion transmembrane transport|mitochondrial processing peptidase complex|metal ion binding PMS1 328.3209345 318.6961741 337.9456949 1.060400853 0.084609736 0.859996189 1 3.188628393 3.526873696 5378 "PMS1 homolog 1, mismatch repair system component" "GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0006298,GO:0016887,GO:0019899,GO:0030983,GO:0032300,GO:0042493" DNA binding|protein binding|ATP binding|nucleus|mismatch repair|ATPase activity|enzyme binding|mismatched DNA binding|mismatch repair complex|response to drug PMS2 535.4922021 538.9416192 532.0427849 0.987199292 -0.018586735 0.968190382 1 5.120144765 5.272335097 5395 "PMS1 homolog 2, mismatch repair system component" "GO:0003677,GO:0003697,GO:0004519,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006298,GO:0016446,GO:0016887,GO:0032138,GO:0032300,GO:0032389,GO:0032407,GO:0036464,GO:0042493,GO:0090305" DNA binding|single-stranded DNA binding|endonuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|mismatch repair|somatic hypermutation of immunoglobulin genes|ATPase activity|single base insertion or deletion binding|mismatch repair complex|MutLalpha complex|MutSalpha complex binding|cytoplasmic ribonucleoprotein granule|response to drug|nucleic acid phosphodiester bond hydrolysis "hsa03430,hsa03460" Mismatch repair|Fanconi anemia pathway PMVK 528.8450077 589.6894176 468.0005979 0.793639133 -0.333444931 0.408646879 1 23.31435496 19.30022659 10654 phosphomevalonate kinase "GO:0004631,GO:0005515,GO:0005524,GO:0005777,GO:0005829,GO:0006695,GO:0016020,GO:0016126,GO:0016310,GO:0019287,GO:0045540,GO:0070062,GO:0070723" "phosphomevalonate kinase activity|protein binding|ATP binding|peroxisome|cytosol|cholesterol biosynthetic process|membrane|sterol biosynthetic process|phosphorylation|isopentenyl diphosphate biosynthetic process, mevalonate pathway|regulation of cholesterol biosynthetic process|extracellular exosome|response to cholesterol" "hsa00900,hsa04146" Terpenoid backbone biosynthesis|Peroxisome PNCK 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.099044199 0.033429456 139728 pregnancy up-regulated nonubiquitous CaM kinase "GO:0004683,GO:0005516,GO:0005524,GO:0005622,GO:0005634,GO:0005737,GO:0018105" calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|intracellular anatomical structure|nucleus|cytoplasm|peptidyl-serine phosphorylation PNISR 1458.839607 1391.504633 1526.174581 1.096780094 0.133274292 0.689830527 1 8.838073829 10.11097681 25957 PNN interacting serine and arginine rich protein "GO:0003723,GO:0005654,GO:0005829,GO:0005886,GO:0016607,GO:0048786" RNA binding|nucleoplasm|cytosol|plasma membrane|nuclear speck|presynaptic active zone PNKD 846.0580881 923.6099312 768.5062449 0.832067975 -0.265226703 0.466071121 1 12.72167112 11.04126671 25953 PNKD metallo-beta-lactamase domain containing "GO:0004416,GO:0005515,GO:0005634,GO:0005739,GO:0016020,GO:0019243,GO:0032225,GO:0042053,GO:0046872,GO:0046929,GO:0050884" "hydroxyacylglutathione hydrolase activity|protein binding|nucleus|mitochondrion|membrane|methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione|regulation of synaptic transmission, dopaminergic|regulation of dopamine metabolic process|metal ion binding|negative regulation of neurotransmitter secretion|neuromuscular process controlling posture" PNKP 429.9313382 394.8178717 465.0448046 1.177871717 0.236182423 0.580649127 1 11.55178069 14.19262927 11284 polynucleotide kinase 3'-phosphatase "GO:0000718,GO:0003684,GO:0003690,GO:0004519,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0006261,GO:0006281,GO:0006979,GO:0009314,GO:0010836,GO:0016020,GO:0016311,GO:0017076,GO:0032212,GO:0042769,GO:0046403,GO:0046404,GO:0046939,GO:0051973,GO:0090305,GO:0098506,GO:1904355,GO:2001034" "nucleotide-excision repair, DNA damage removal|damaged DNA binding|double-stranded DNA binding|endonuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|mitochondrion|DNA-dependent DNA replication|DNA repair|response to oxidative stress|response to radiation|negative regulation of protein ADP-ribosylation|membrane|dephosphorylation|purine nucleotide binding|positive regulation of telomere maintenance via telomerase|DNA damage response, detection of DNA damage|polynucleotide 3'-phosphatase activity|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|nucleotide phosphorylation|positive regulation of telomerase activity|nucleic acid phosphodiester bond hydrolysis|polynucleotide 3' dephosphorylation|positive regulation of telomere capping|positive regulation of double-strand break repair via nonhomologous end joining" PNMA1 1564.987621 1474.731022 1655.24422 1.12240415 0.166592249 0.614271657 1 28.70481312 33.60623944 9240 PNMA family member 1 "GO:0002437,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0043065" inflammatory response to antigenic stimulus|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|positive regulation of apoptotic process PNN 1721.042421 1905.072353 1537.01249 0.806800061 -0.309716902 0.342855475 1 27.27882216 22.95659468 5411 "pinin, desmosome associated protein" "GO:0000398,GO:0003677,GO:0003723,GO:0005198,GO:0005515,GO:0005882,GO:0005886,GO:0005911,GO:0007155,GO:0016020,GO:0016607,GO:0030057,GO:0035145,GO:0071013" "mRNA splicing, via spliceosome|DNA binding|RNA binding|structural molecule activity|protein binding|intermediate filament|plasma membrane|cell-cell junction|cell adhesion|membrane|nuclear speck|desmosome|exon-exon junction complex|catalytic step 2 spliceosome" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway PNO1 399.3678523 460.7900096 337.9456949 0.733404995 -0.447318002 0.302901773 1 7.341109915 5.615927855 56902 partner of NOB1 homolog "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005829" RNA binding|protein binding|nucleoplasm|nucleolus|cytosol PNP 1104.527932 1080.928106 1128.127757 1.043665856 0.061659887 0.861103777 1 37.06512884 40.34994241 4860 purine nucleoside phosphorylase "GO:0001882,GO:0002060,GO:0004731,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0006139,GO:0006148,GO:0006195,GO:0006738,GO:0006955,GO:0009165,GO:0032623,GO:0034418,GO:0034774,GO:0042102,GO:0042301,GO:0042493,GO:0042802,GO:0043101,GO:0043312,GO:0046638,GO:0070062,GO:1904813" nucleoside binding|purine nucleobase binding|purine-nucleoside phosphorylase activity|protein binding|extracellular region|nucleus|cytoplasm|cytosol|cytoskeleton|nucleobase-containing compound metabolic process|inosine catabolic process|purine nucleotide catabolic process|nicotinamide riboside catabolic process|immune response|nucleotide biosynthetic process|interleukin-2 production|urate biosynthetic process|secretory granule lumen|positive regulation of T cell proliferation|phosphate ion binding|response to drug|identical protein binding|purine-containing compound salvage|neutrophil degranulation|positive regulation of alpha-beta T cell differentiation|extracellular exosome|ficolin-1-rich granule lumen "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism PNPLA2 1888.038059 1803.576756 1972.499362 1.093659782 0.129164012 0.690702897 1 43.6430005 49.78663485 57104 patatin like phospholipase domain containing 2 "GO:0004806,GO:0005654,GO:0005737,GO:0005788,GO:0005789,GO:0005811,GO:0005829,GO:0005886,GO:0006651,GO:0010891,GO:0010898,GO:0016020,GO:0016021,GO:0019433,GO:0019915,GO:0034389,GO:0036155,GO:0042572,GO:0043687,GO:0044267,GO:0050253,GO:0055088" triglyceride lipase activity|nucleoplasm|cytoplasm|endoplasmic reticulum lumen|endoplasmic reticulum membrane|lipid droplet|cytosol|plasma membrane|diacylglycerol biosynthetic process|negative regulation of sequestering of triglyceride|positive regulation of triglyceride catabolic process|membrane|integral component of membrane|triglyceride catabolic process|lipid storage|lipid droplet organization|acylglycerol acyl-chain remodeling|retinol metabolic process|post-translational protein modification|cellular protein metabolic process|retinyl-palmitate esterase activity|lipid homeostasis "hsa00561,hsa04714,hsa04923" Glycerolipid metabolism|Thermogenesis|Regulation of lipolysis in adipocytes PNPLA3 164.0598873 202.9911937 125.1285809 0.616423691 -0.698005784 0.22543608 1 3.734394424 2.401128693 80339 patatin like phospholipase domain containing 3 "GO:0001676,GO:0003841,GO:0004623,GO:0004806,GO:0005737,GO:0005789,GO:0005811,GO:0006650,GO:0006654,GO:0009744,GO:0016020,GO:0016021,GO:0019432,GO:0019433,GO:0032869,GO:0034389,GO:0035727,GO:0036042,GO:0036153,GO:0036155,GO:0042171,GO:0050872,GO:0051264,GO:0051265,GO:0055088,GO:1905243" "long-chain fatty acid metabolic process|1-acylglycerol-3-phosphate O-acyltransferase activity|phospholipase A2 activity|triglyceride lipase activity|cytoplasm|endoplasmic reticulum membrane|lipid droplet|glycerophospholipid metabolic process|phosphatidic acid biosynthetic process|response to sucrose|membrane|integral component of membrane|triglyceride biosynthetic process|triglyceride catabolic process|cellular response to insulin stimulus|lipid droplet organization|lysophosphatidic acid binding|long-chain fatty acyl-CoA binding|triglyceride acyl-chain remodeling|acylglycerol acyl-chain remodeling|lysophosphatidic acid acyltransferase activity|white fat cell differentiation|mono-olein transacylation activity|diolein transacylation activity|lipid homeostasis|cellular response to 3,3',5-triiodo-L-thyronine" hsa00561 Glycerolipid metabolism PNPLA4 240.8159939 263.8885518 217.7434361 0.825134075 -0.277299535 0.588144531 1 3.138066261 2.700863038 8228 patatin like phospholipase domain containing 4 "GO:0004806,GO:0005737,GO:0005739,GO:0005811,GO:0005829,GO:0008150,GO:0016020,GO:0019433,GO:0042572,GO:0050253,GO:0055088" triglyceride lipase activity|cytoplasm|mitochondrion|lipid droplet|cytosol|biological_process|membrane|triglyceride catabolic process|retinol metabolic process|retinyl-palmitate esterase activity|lipid homeostasis hsa00830 Retinol metabolism PNPLA6 2250.756895 2082.689647 2418.824143 1.161394424 0.215858012 0.500366443 1 21.2448909 25.73654066 10908 patatin like phospholipase domain containing 6 "GO:0004622,GO:0005783,GO:0005789,GO:0005829,GO:0016020,GO:0016021,GO:0046470,GO:0046475,GO:0102545" lysophospholipase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|membrane|integral component of membrane|phosphatidylcholine metabolic process|glycerophospholipid catabolic process|phosphatidyl phospholipase B activity hsa00564 Glycerophospholipid metabolism PNPLA7 48.63153343 57.8524902 39.41057666 0.681225242 -0.553796201 0.525124616 1 0.585536478 0.416064458 375775 patatin like phospholipase domain containing 7 "GO:0004622,GO:0005783,GO:0005789,GO:0005811,GO:0016021,GO:0034638,GO:0102545" lysophospholipase activity|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|integral component of membrane|phosphatidylcholine catabolic process|phosphatidyl phospholipase B activity hsa00564 Glycerophospholipid metabolism PNPLA8 791.983352 796.7404352 787.2262688 0.988058638 -0.017331432 0.966188391 1 7.282456652 7.505446905 50640 patatin like phospholipase domain containing 8 "GO:0001516,GO:0004620,GO:0004622,GO:0005524,GO:0005739,GO:0005777,GO:0005778,GO:0005789,GO:0006631,GO:0008219,GO:0016020,GO:0016021,GO:0019369,GO:0031966,GO:0034638,GO:0036151,GO:0036152,GO:0043651,GO:0046338,GO:0047499,GO:0050482,GO:0055088,GO:0070328,GO:0102545" prostaglandin biosynthetic process|phospholipase activity|lysophospholipase activity|ATP binding|mitochondrion|peroxisome|peroxisomal membrane|endoplasmic reticulum membrane|fatty acid metabolic process|cell death|membrane|integral component of membrane|arachidonic acid metabolic process|mitochondrial membrane|phosphatidylcholine catabolic process|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|linoleic acid metabolic process|phosphatidylethanolamine catabolic process|calcium-independent phospholipase A2 activity|arachidonic acid secretion|lipid homeostasis|triglyceride homeostasis|phosphatidyl phospholipase B activity PNPO 683.2925049 775.4263598 591.1586499 0.762365945 -0.391444419 0.302762118 1 11.33735843 9.015530665 55163 pyridoxamine 5'-phosphate oxidase "GO:0004733,GO:0005515,GO:0005829,GO:0008615,GO:0010181,GO:0030170,GO:0042803,GO:0042816,GO:0042823,GO:0055114" pyridoxamine-phosphate oxidase activity|protein binding|cytosol|pyridoxine biosynthetic process|FMN binding|pyridoxal phosphate binding|protein homodimerization activity|vitamin B6 metabolic process|pyridoxal phosphate biosynthetic process|oxidation-reduction process hsa00750 Vitamin B6 metabolism PNPT1 532.7118365 584.6146378 480.8090353 0.822437558 -0.282021945 0.484346847 1 6.514558637 5.588610757 87178 polyribonucleotide nucleotidyltransferase 1 "GO:0000175,GO:0000957,GO:0000958,GO:0000962,GO:0000964,GO:0000965,GO:0003723,GO:0004654,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005758,GO:0005759,GO:0005789,GO:0005829,GO:0006401,GO:0006402,GO:0008266,GO:0034046,GO:0034599,GO:0035198,GO:0035458,GO:0035927,GO:0035928,GO:0042788,GO:0043457,GO:0043631,GO:0045025,GO:0045926,GO:0051260,GO:0051591,GO:0060416,GO:0061014,GO:0070207,GO:0070584,GO:0071042,GO:0071850,GO:0090503,GO:0097222,GO:0097421,GO:2000627,GO:2000772" "3'-5'-exoribonuclease activity|mitochondrial RNA catabolic process|mitochondrial mRNA catabolic process|positive regulation of mitochondrial RNA catabolic process|mitochondrial RNA 5'-end processing|mitochondrial RNA 3'-end processing|RNA binding|polyribonucleotide nucleotidyltransferase activity|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|endoplasmic reticulum membrane|cytosol|RNA catabolic process|mRNA catabolic process|poly(U) RNA binding|poly(G) binding|cellular response to oxidative stress|miRNA binding|cellular response to interferon-beta|RNA import into mitochondrion|rRNA import into mitochondrion|polysomal ribosome|regulation of cellular respiration|RNA polyadenylation|mitochondrial degradosome|negative regulation of growth|protein homooligomerization|response to cAMP|response to growth hormone|positive regulation of mRNA catabolic process|protein homotrimerization|mitochondrion morphogenesis|nuclear polyadenylation-dependent mRNA catabolic process|mitotic cell cycle arrest|RNA phosphodiester bond hydrolysis, exonucleolytic|mitochondrial mRNA polyadenylation|liver regeneration|positive regulation of miRNA catabolic process|regulation of cellular senescence" hsa03018 RNA degradation PNRC1 888.2435871 944.9240066 831.5631676 0.880031793 -0.18437245 0.609849908 1 22.87622727 20.9990039 10957 proline rich nuclear receptor coactivator 1 "GO:0005515,GO:0005634" protein binding|nucleus PNRC2 1722.295156 1552.882632 1891.70768 1.218191022 0.284740377 0.383207229 1 31.54754394 40.0863836 55629 proline rich nuclear receptor coactivator 2 "GO:0000184,GO:0000932,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0031087" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|P-body|protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|deadenylation-independent decapping of nuclear-transcribed mRNA" POC1A 942.1376983 722.6486495 1161.626747 1.607457162 0.684780291 0.05501889 1 12.04330528 20.19300872 25886 POC1 centriolar protein A "GO:0000922,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0030030,GO:0036064" spindle pole|protein binding|cytoplasm|centrosome|centriole|cell projection organization|ciliary basal body POC1B 460.2194353 411.0571672 509.3817034 1.239199177 0.309408091 0.459681927 1 6.40572166 8.27990035 282809 POC1 centriolar protein B "GO:0000922,GO:0001895,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0007099,GO:0008283,GO:0036064,GO:0060271" spindle pole|retina homeostasis|protein binding|cytoplasm|centrosome|centriole|centriole replication|cell population proliferation|ciliary basal body|cilium assembly POC5 236.3877472 196.9014579 275.8740366 1.401076658 0.486535894 0.341501781 1 3.698948151 5.405751424 134359 POC5 centriolar protein "GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0007049" protein binding|nucleoplasm|centrosome|centriole|cytosol|cell cycle PODN 2.463161041 0 4.926322083 Inf Inf 0.189235799 1 0 0.066153614 127435 podocan "GO:0005518,GO:0005615,GO:0005737,GO:0008285,GO:0030021,GO:0030336,GO:0062023" collagen binding|extracellular space|cytoplasm|negative regulation of cell population proliferation|extracellular matrix structural constituent conferring compression resistance|negative regulation of cell migration|collagen-containing extracellular matrix PODNL1 7.92665266 3.044867905 12.80843742 4.206565872 2.072642936 0.198592907 1 0.044518423 0.195336498 79883 podocan like 1 GO:0005615 extracellular space PODXL 3321.071017 4428.25289 2213.889144 0.499946412 -1.00015463 0.001820416 0.132655503 37.46665335 19.53818816 5420 podocalyxin like "GO:0001726,GO:0005515,GO:0005615,GO:0005730,GO:0005737,GO:0005886,GO:0005887,GO:0007155,GO:0007162,GO:0016324,GO:0016477,GO:0022408,GO:0030027,GO:0030175,GO:0030335,GO:0031528,GO:0032534,GO:0033634,GO:0034451,GO:0036057,GO:0043231,GO:0045121,GO:0070062,GO:0072015,GO:0072175" ruffle|protein binding|extracellular space|nucleolus|cytoplasm|plasma membrane|integral component of plasma membrane|cell adhesion|negative regulation of cell adhesion|apical plasma membrane|cell migration|negative regulation of cell-cell adhesion|lamellipodium|filopodium|positive regulation of cell migration|microvillus membrane|regulation of microvillus assembly|positive regulation of cell-cell adhesion mediated by integrin|centriolar satellite|slit diaphragm|intracellular membrane-bounded organelle|membrane raft|extracellular exosome|glomerular visceral epithelial cell development|epithelial tube formation hsa05132 Salmonella infection POFUT1 6211.219981 6507.897669 5914.542293 0.908825337 -0.137925039 0.671483311 1 53.663637 50.87172439 23509 protein O-fucosyltransferase 1 "GO:0001525,GO:0001756,GO:0005783,GO:0006004,GO:0006355,GO:0006493,GO:0007219,GO:0007399,GO:0007507,GO:0008417,GO:0008593,GO:0016020,GO:0016266,GO:0036066,GO:0046922" "angiogenesis|somitogenesis|endoplasmic reticulum|fucose metabolic process|regulation of transcription, DNA-templated|protein O-linked glycosylation|Notch signaling pathway|nervous system development|heart development|fucosyltransferase activity|regulation of Notch signaling pathway|membrane|O-glycan processing|protein O-linked fucosylation|peptide-O-fucosyltransferase activity" hsa00514 Other types of O-glycan biosynthesis POFUT2 1326.175807 1347.861526 1304.490088 0.967822037 -0.047186306 0.890750346 1 12.35555318 12.47307778 23275 protein O-fucosyltransferase 2 "GO:0001707,GO:0005789,GO:0005794,GO:0006004,GO:0010468,GO:0010717,GO:0036066,GO:0046922,GO:0051046,GO:1903334" mesoderm formation|endoplasmic reticulum membrane|Golgi apparatus|fucose metabolic process|regulation of gene expression|regulation of epithelial to mesenchymal transition|protein O-linked fucosylation|peptide-O-fucosyltransferase activity|regulation of secretion|positive regulation of protein folding hsa00514 Other types of O-glycan biosynthesis POGK 1706.035571 1586.376179 1825.694964 1.150858787 0.202710822 0.535445732 1 12.00065079 14.40597862 57645 pogo transposable element derived with KRAB domain "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0007275" "DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|multicellular organism development" POGLUT1 384.2946921 406.9973433 361.5920409 0.888438332 -0.170656455 0.700860457 1 5.189571913 4.809221193 56983 protein O-glucosyltransferase 1 "GO:0001756,GO:0005783,GO:0005788,GO:0006493,GO:0007369,GO:0010470,GO:0012505,GO:0018242,GO:0035251,GO:0035252,GO:0045747,GO:0046527,GO:0048318,GO:0048339,GO:0060537,GO:0072359,GO:0140561,GO:0140562" somitogenesis|endoplasmic reticulum|endoplasmic reticulum lumen|protein O-linked glycosylation|gastrulation|regulation of gastrulation|endomembrane system|protein O-linked glycosylation via serine|UDP-glucosyltransferase activity|UDP-xylosyltransferase activity|positive regulation of Notch signaling pathway|glucosyltransferase activity|axial mesoderm development|paraxial mesoderm development|muscle tissue development|circulatory system development|EGF-domain serine glucosyltransferase activity|EGF-domain serine xylosyltransferase activity hsa00514 Other types of O-glycan biosynthesis POGLUT2 442.1377797 454.7002738 429.5752856 0.944743846 -0.082004879 0.850599811 1 10.60265414 10.44827504 79070 protein O-glucosyltransferase 2 "GO:0005654,GO:0005788,GO:0005829,GO:0012505,GO:0018242,GO:0035251,GO:0035252,GO:0046527" nucleoplasm|endoplasmic reticulum lumen|cytosol|endomembrane system|protein O-linked glycosylation via serine|UDP-glucosyltransferase activity|UDP-xylosyltransferase activity|glucosyltransferase activity POGLUT3 3687.177404 2884.504862 4489.849946 1.556540953 0.638343535 0.045522551 0.96408227 32.50778713 52.77933189 143888 protein O-glucosyltransferase 3 "GO:0005575,GO:0005788,GO:0012505,GO:0018242,GO:0035251,GO:0035252,GO:0046527" cellular_component|endoplasmic reticulum lumen|endomembrane system|protein O-linked glycosylation via serine|UDP-glucosyltransferase activity|UDP-xylosyltransferase activity|glucosyltransferase activity POGZ 2784.881802 2730.231555 2839.532048 1.040033415 0.056629881 0.859787319 1 17.97433986 19.49917208 23126 pogo transposable element derived with ZNF domain "GO:0000785,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007064,GO:0010468,GO:0045944,GO:0046872,GO:0051301,GO:0051382" chromatin|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mitotic sister chromatid cohesion|regulation of gene expression|positive regulation of transcription by RNA polymerase II|metal ion binding|cell division|kinetochore assembly POLA1 1396.201088 1386.429853 1405.972322 1.014095534 0.02019357 0.954156553 1 7.580457844 8.018446519 5422 "DNA polymerase alpha 1, catalytic subunit" "GO:0000082,GO:0000083,GO:0000166,GO:0000731,GO:0000785,GO:0003677,GO:0003682,GO:0003688,GO:0003697,GO:0003887,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005658,GO:0005730,GO:0005829,GO:0006260,GO:0006269,GO:0006270,GO:0006271,GO:0006272,GO:0006273,GO:0006281,GO:0006289,GO:0006303,GO:0016032,GO:0016363,GO:0017076,GO:0019103,GO:0019901,GO:0032201,GO:0032479,GO:0046872,GO:0051539,GO:1902975,GO:1904161" "G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|nucleotide binding|DNA synthesis involved in DNA repair|chromatin|DNA binding|chromatin binding|DNA replication origin binding|single-stranded DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nuclear envelope|nucleoplasm|alpha DNA polymerase:primase complex|nucleolus|cytosol|DNA replication|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA strand elongation involved in DNA replication|leading strand elongation|lagging strand elongation|DNA repair|nucleotide-excision repair|double-strand break repair via nonhomologous end joining|viral process|nuclear matrix|purine nucleotide binding|pyrimidine nucleotide binding|protein kinase binding|telomere maintenance via semi-conservative replication|regulation of type I interferon production|metal ion binding|4 iron, 4 sulfur cluster binding|mitotic DNA replication initiation|DNA synthesis involved in UV-damage excision repair" hsa03030 DNA replication POLA2 1230.960219 1203.737778 1258.18266 1.045229852 0.063820234 0.853486786 1 11.68808895 12.74298707 23649 "DNA polymerase alpha 2, accessory subunit" "GO:0000082,GO:0003674,GO:0003677,GO:0005515,GO:0005654,GO:0005658,GO:0005829,GO:0006260,GO:0006269,GO:0006270,GO:0032201" "G1/S transition of mitotic cell cycle|molecular_function|DNA binding|protein binding|nucleoplasm|alpha DNA polymerase:primase complex|cytosol|DNA replication|DNA replication, synthesis of RNA primer|DNA replication initiation|telomere maintenance via semi-conservative replication" hsa03030 DNA replication POLB 198.6062466 173.5574706 223.6550226 1.288651084 0.365861691 0.501000008 1 6.108459772 8.210753066 5423 DNA polymerase beta "GO:0001701,GO:0003684,GO:0003887,GO:0003906,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005874,GO:0005876,GO:0006261,GO:0006281,GO:0006284,GO:0006286,GO:0006287,GO:0006288,GO:0006290,GO:0006297,GO:0006303,GO:0006954,GO:0006974,GO:0007435,GO:0007568,GO:0008017,GO:0008630,GO:0010332,GO:0016446,GO:0016579,GO:0016829,GO:0019899,GO:0032991,GO:0045471,GO:0046872,GO:0048535,GO:0048536,GO:0048872,GO:0051402,GO:0055093,GO:0071707,GO:0071897" "in utero embryonic development|damaged DNA binding|DNA-directed DNA polymerase activity|DNA-(apurinic or apyrimidinic site) endonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|microtubule|spindle microtubule|DNA-dependent DNA replication|DNA repair|base-excision repair|base-excision repair, base-free sugar-phosphate removal|base-excision repair, gap-filling|base-excision repair, DNA ligation|pyrimidine dimer repair|nucleotide-excision repair, DNA gap filling|double-strand break repair via nonhomologous end joining|inflammatory response|cellular response to DNA damage stimulus|salivary gland morphogenesis|aging|microtubule binding|intrinsic apoptotic signaling pathway in response to DNA damage|response to gamma radiation|somatic hypermutation of immunoglobulin genes|protein deubiquitination|lyase activity|enzyme binding|protein-containing complex|response to ethanol|metal ion binding|lymph node development|spleen development|homeostasis of number of cells|neuron apoptotic process|response to hyperoxia|immunoglobulin heavy chain V-D-J recombination|DNA biosynthetic process" "hsa03410,hsa05166,hsa05203" Base excision repair|Human T-cell leukemia virus 1 infection|Viral carcinogenesis POLD1 1363.970915 1203.737778 1524.204052 1.266225983 0.340534906 0.310536819 1 15.84331392 20.92537156 5424 "DNA polymerase delta 1, catalytic subunit" "GO:0000109,GO:0000166,GO:0000723,GO:0000731,GO:0000781,GO:0003677,GO:0003682,GO:0003684,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006261,GO:0006281,GO:0006283,GO:0006287,GO:0006296,GO:0006297,GO:0006298,GO:0008296,GO:0009411,GO:0016020,GO:0016235,GO:0019985,GO:0032201,GO:0033683,GO:0034644,GO:0042769,GO:0043625,GO:0045004,GO:0046872,GO:0051539,GO:0055089,GO:0070987,GO:0071897" "nucleotide-excision repair complex|nucleotide binding|telomere maintenance|DNA synthesis involved in DNA repair|chromosome, telomeric region|DNA binding|chromatin binding|damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|cytosol|DNA replication|DNA-dependent DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair, gap-filling|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|3'-5'-exodeoxyribonuclease activity|response to UV|membrane|aggresome|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|cellular response to UV|DNA damage response, detection of DNA damage|delta DNA polymerase complex|DNA replication proofreading|metal ion binding|4 iron, 4 sulfur cluster binding|fatty acid homeostasis|error-free translesion synthesis|DNA biosynthetic process" "hsa03030,hsa03410,hsa03420,hsa03430,hsa03440" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination POLD2 2493.003526 2377.026878 2608.980175 1.097581268 0.134327765 0.674342786 1 54.49887991 62.39362132 5425 "DNA polymerase delta 2, accessory subunit" "GO:0000723,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006271,GO:0006283,GO:0006296,GO:0006297,GO:0006298,GO:0016035,GO:0019985,GO:0032201,GO:0033683,GO:0042575,GO:0042769,GO:0043625,GO:0071897" "telomere maintenance|DNA binding|protein binding|nucleus|nucleoplasm|DNA replication|DNA strand elongation involved in DNA replication|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|zeta DNA polymerase complex|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|DNA polymerase complex|DNA damage response, detection of DNA damage|delta DNA polymerase complex|DNA biosynthetic process" "hsa03030,hsa03410,hsa03420,hsa03430,hsa03440" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination POLD3 1075.32506 936.8043588 1213.845761 1.295730266 0.373765422 0.28308991 1 11.38882283 15.39250737 10714 "DNA polymerase delta 3, accessory subunit" "GO:0000723,GO:0000731,GO:0003887,GO:0005515,GO:0005654,GO:0005737,GO:0006271,GO:0006283,GO:0006296,GO:0006297,GO:0006298,GO:0016035,GO:0019985,GO:0030674,GO:0032201,GO:0033683,GO:0042769,GO:0043625,GO:0071897,GO:1904161" "telomere maintenance|DNA synthesis involved in DNA repair|DNA-directed DNA polymerase activity|protein binding|nucleoplasm|cytoplasm|DNA strand elongation involved in DNA replication|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|zeta DNA polymerase complex|translesion synthesis|protein-macromolecule adaptor activity|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|DNA damage response, detection of DNA damage|delta DNA polymerase complex|DNA biosynthetic process|DNA synthesis involved in UV-damage excision repair" "hsa03030,hsa03410,hsa03420,hsa03430,hsa03440" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination POLD4 809.4954249 781.5160956 837.4747541 1.071602695 0.099770114 0.787997209 1 23.36542693 26.11700953 57804 "DNA polymerase delta 4, accessory subunit" "GO:0000723,GO:0000731,GO:0003887,GO:0005515,GO:0005654,GO:0006261,GO:0006283,GO:0006296,GO:0006297,GO:0006298,GO:0019985,GO:0032201,GO:0033683,GO:0042769,GO:0043625" "telomere maintenance|DNA synthesis involved in DNA repair|DNA-directed DNA polymerase activity|protein binding|nucleoplasm|DNA-dependent DNA replication|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|DNA damage response, detection of DNA damage|delta DNA polymerase complex" "hsa03030,hsa03410,hsa03420,hsa03430,hsa03440" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination POLDIP2 2719.415658 2801.278473 2637.552843 0.941553247 -0.086885409 0.785808089 1 53.1366563 52.1861235 26073 DNA polymerase delta interacting protein 2 "GO:0003677,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0016242,GO:0042645,GO:0045931,GO:0070584,GO:0070987" DNA binding|protein binding|nucleus|mitochondrion|mitochondrial matrix|negative regulation of macroautophagy|mitochondrial nucleoid|positive regulation of mitotic cell cycle|mitochondrion morphogenesis|error-free translesion synthesis POLDIP3 2245.687312 2376.011922 2115.362702 0.8902997 -0.167637025 0.600986979 1 34.75927839 32.27921085 84271 DNA polymerase delta interacting protein 3 "GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0016607,GO:0016973,GO:0031124,GO:0036464,GO:0044877,GO:0045727" RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|nuclear speck|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|cytoplasmic ribonucleoprotein granule|protein-containing complex binding|positive regulation of translation POLE 3051.853324 2795.188737 3308.517911 1.183647411 0.24323939 0.444636591 1 15.99801658 19.75169745 5426 "DNA polymerase epsilon, catalytic subunit" "GO:0000082,GO:0000166,GO:0000278,GO:0000731,GO:0003677,GO:0003682,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006260,GO:0006270,GO:0006272,GO:0006287,GO:0006297,GO:0008270,GO:0008310,GO:0008622,GO:0032201,GO:0045004,GO:0048568,GO:0051539,GO:0090305" "G1/S transition of mitotic cell cycle|nucleotide binding|mitotic cell cycle|DNA synthesis involved in DNA repair|DNA binding|chromatin binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|plasma membrane|DNA replication|DNA replication initiation|leading strand elongation|base-excision repair, gap-filling|nucleotide-excision repair, DNA gap filling|zinc ion binding|single-stranded DNA 3'-5' exodeoxyribonuclease activity|epsilon DNA polymerase complex|telomere maintenance via semi-conservative replication|DNA replication proofreading|embryonic organ development|4 iron, 4 sulfur cluster binding|nucleic acid phosphodiester bond hydrolysis" "hsa03030,hsa03410,hsa03420" DNA replication|Base excision repair|Nucleotide excision repair POLE2 167.3180393 156.3032191 178.3328594 1.140941693 0.190225065 0.746526089 1 4.063761111 4.83623672 5427 "DNA polymerase epsilon 2, accessory subunit" "GO:0000082,GO:0003677,GO:0003887,GO:0005515,GO:0005654,GO:0006260,GO:0006261,GO:0006270,GO:0006281,GO:0008622,GO:0016604,GO:0032201,GO:0042276,GO:0043231" G1/S transition of mitotic cell cycle|DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleoplasm|DNA replication|DNA-dependent DNA replication|DNA replication initiation|DNA repair|epsilon DNA polymerase complex|nuclear body|telomere maintenance via semi-conservative replication|error-prone translesion synthesis|intracellular membrane-bounded organelle "hsa03030,hsa03410,hsa03420" DNA replication|Base excision repair|Nucleotide excision repair POLE3 1960.342908 1896.952705 2023.733112 1.06683372 0.093335331 0.773495162 1 43.78940859 48.72835426 54107 "DNA polymerase epsilon 3, accessory subunit" "GO:0000082,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0006260,GO:0006270,GO:0006272,GO:0006974,GO:0008622,GO:0008623,GO:0031490,GO:0031507,GO:0032201,GO:0042766,GO:0043966,GO:0046982,GO:0071897" G1/S transition of mitotic cell cycle|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|DNA replication|DNA replication initiation|leading strand elongation|cellular response to DNA damage stimulus|epsilon DNA polymerase complex|CHRAC|chromatin DNA binding|heterochromatin assembly|telomere maintenance via semi-conservative replication|nucleosome mobilization|histone H3 acetylation|protein heterodimerization activity|DNA biosynthetic process "hsa03030,hsa03410,hsa03420" DNA replication|Base excision repair|Nucleotide excision repair POLE4 194.1280194 170.5126027 217.7434361 1.276993211 0.352750855 0.519939136 1 7.87225323 10.48584839 56655 "DNA polymerase epsilon 4, accessory subunit" "GO:0000082,GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0006270,GO:0008622,GO:0032201,GO:0046982,GO:0071897" G1/S transition of mitotic cell cycle|DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|DNA replication initiation|epsilon DNA polymerase complex|telomere maintenance via semi-conservative replication|protein heterodimerization activity|DNA biosynthetic process "hsa03030,hsa03410,hsa03420" DNA replication|Base excision repair|Nucleotide excision repair POLG 2559.95301 2238.992866 2880.913154 1.286700461 0.363676239 0.254279526 1 25.4139601 34.10874421 5428 "DNA polymerase gamma, catalytic subunit" "GO:0002020,GO:0003677,GO:0003682,GO:0003887,GO:0005515,GO:0005739,GO:0005760,GO:0006259,GO:0006261,GO:0006264,GO:0006287,GO:0007568,GO:0008408,GO:0009416,GO:0010332,GO:0032991,GO:0042645,GO:0043195,GO:0055093,GO:0071333,GO:0071897,GO:0090305" "protease binding|DNA binding|chromatin binding|DNA-directed DNA polymerase activity|protein binding|mitochondrion|gamma DNA polymerase complex|DNA metabolic process|DNA-dependent DNA replication|mitochondrial DNA replication|base-excision repair, gap-filling|aging|3'-5' exonuclease activity|response to light stimulus|response to gamma radiation|protein-containing complex|mitochondrial nucleoid|terminal bouton|response to hyperoxia|cellular response to glucose stimulus|DNA biosynthetic process|nucleic acid phosphodiester bond hydrolysis" POLG2 188.7805724 209.0809295 168.4802152 0.805813403 -0.311482294 0.574452514 1 6.693559725 5.62610145 11232 "DNA polymerase gamma 2, accessory subunit" "GO:0001701,GO:0003690,GO:0003887,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005760,GO:0006261,GO:0006264,GO:0006281,GO:0007005,GO:0022904,GO:0030337,GO:0032042,GO:0042645,GO:0042802,GO:0070182,GO:0070584,GO:0071897,GO:1900264" in utero embryonic development|double-stranded DNA binding|DNA-directed DNA polymerase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|gamma DNA polymerase complex|DNA-dependent DNA replication|mitochondrial DNA replication|DNA repair|mitochondrion organization|respiratory electron transport chain|DNA polymerase processivity factor activity|mitochondrial DNA metabolic process|mitochondrial nucleoid|identical protein binding|DNA polymerase binding|mitochondrion morphogenesis|DNA biosynthetic process|positive regulation of DNA-directed DNA polymerase activity POLH 532.8860265 461.8049656 603.9670873 1.307840176 0.387186247 0.336148551 1 2.096333455 2.8597691 5429 DNA polymerase eta "GO:0000731,GO:0003684,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005829,GO:0006260,GO:0006281,GO:0006282,GO:0006290,GO:0009314,GO:0010225,GO:0019985,GO:0035861,GO:0042276,GO:0046872,GO:0070987,GO:0071494" DNA synthesis involved in DNA repair|damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|replication fork|cytosol|DNA replication|DNA repair|regulation of DNA repair|pyrimidine dimer repair|response to radiation|response to UV-C|translesion synthesis|site of double-strand break|error-prone translesion synthesis|metal ion binding|error-free translesion synthesis|cellular response to UV-C "hsa01524,hsa03460" Platinum drug resistance|Fanconi anemia pathway POLI 344.886837 373.5037964 316.2698777 0.846764828 -0.23996675 0.599017737 1 3.930324048 3.471419499 11201 DNA polymerase iota "GO:0003684,GO:0003887,GO:0005515,GO:0005654,GO:0006260,GO:0006281,GO:0016607,GO:0019985,GO:0036464,GO:0042276,GO:0046872" damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleoplasm|DNA replication|DNA repair|nuclear speck|translesion synthesis|cytoplasmic ribonucleoprotein granule|error-prone translesion synthesis|metal ion binding hsa03460 Fanconi anemia pathway POLK 550.0215117 488.1938208 611.8492027 1.253291575 0.325722093 0.415187972 1 5.064583117 6.620819574 51426 DNA polymerase kappa "GO:0003684,GO:0003887,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0006283,GO:0006296,GO:0006297,GO:0006974,GO:0016604,GO:0019985,GO:0033683,GO:0034644,GO:0042276,GO:0046872,GO:0090734" "damaged DNA binding|DNA-directed DNA polymerase activity|nucleus|nucleoplasm|DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|cellular response to DNA damage stimulus|nuclear body|translesion synthesis|nucleotide-excision repair, DNA incision|cellular response to UV|error-prone translesion synthesis|metal ion binding|site of DNA damage" "hsa03460,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Fanconi anemia pathway|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer POLL 1147.60962 1096.152446 1199.066795 1.093886895 0.129463574 0.708503943 1 19.26978632 21.98696311 27343 DNA polymerase lambda "GO:0000724,GO:0003677,GO:0003887,GO:0005634,GO:0005654,GO:0006260,GO:0006287,GO:0006289,GO:0006303,GO:0016446,GO:0046872,GO:0051575,GO:0071897" "double-strand break repair via homologous recombination|DNA binding|DNA-directed DNA polymerase activity|nucleus|nucleoplasm|DNA replication|base-excision repair, gap-filling|nucleotide-excision repair|double-strand break repair via nonhomologous end joining|somatic hypermutation of immunoglobulin genes|metal ion binding|5'-deoxyribose-5-phosphate lyase activity|DNA biosynthetic process" "hsa03410,hsa03450" Base excision repair|Non-homologous end-joining POLM 858.635674 1008.866233 708.4051155 0.702179429 -0.510088362 0.159375304 1 17.87181379 13.08978951 27434 DNA polymerase mu "GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0006303,GO:0006310,GO:0046872,GO:0071897" DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|DNA recombination|metal ion binding|DNA biosynthetic process hsa03450 Non-homologous end-joining POLN 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.047406031 0.048001534 353497 DNA polymerase nu "GO:0000724,GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006261,GO:0019985,GO:0030332,GO:0036297" double-strand break repair via homologous recombination|DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA-dependent DNA replication|translesion synthesis|cyclin binding|interstrand cross-link repair hsa03460 Fanconi anemia pathway POLQ 799.1528701 748.0225487 850.2831915 1.136707968 0.184861659 0.616394993 1 4.326219393 5.12948039 10721 DNA polymerase theta "GO:0000724,GO:0003682,GO:0003684,GO:0003887,GO:0005515,GO:0005524,GO:0005654,GO:0005694,GO:0005737,GO:0005794,GO:0005829,GO:0006261,GO:0006281,GO:0006284,GO:0006302,GO:0006974,GO:0008409,GO:0016446,GO:0017116,GO:0032508,GO:0051260,GO:0051575,GO:0071897,GO:0090305,GO:0097681,GO:2000042" double-strand break repair via homologous recombination|chromatin binding|damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|ATP binding|nucleoplasm|chromosome|cytoplasm|Golgi apparatus|cytosol|DNA-dependent DNA replication|DNA repair|base-excision repair|double-strand break repair|cellular response to DNA damage stimulus|5'-3' exonuclease activity|somatic hypermutation of immunoglobulin genes|single-stranded DNA helicase activity|DNA duplex unwinding|protein homooligomerization|5'-deoxyribose-5-phosphate lyase activity|DNA biosynthetic process|nucleic acid phosphodiester bond hydrolysis|double-strand break repair via alternative nonhomologous end joining|negative regulation of double-strand break repair via homologous recombination POLR1A 1488.563318 1739.63453 1237.492107 0.711351773 -0.491364926 0.138967089 1 7.059803836 5.23833154 25885 RNA polymerase I subunit A "GO:0001054,GO:0003677,GO:0003682,GO:0003899,GO:0005515,GO:0005654,GO:0005694,GO:0005736,GO:0006361,GO:0006362,GO:0006363,GO:0008270,GO:0045815,GO:1904750" "RNA polymerase I activity|DNA binding|chromatin binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|chromosome|RNA polymerase I complex|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|zinc ion binding|positive regulation of gene expression, epigenetic|negative regulation of protein localization to nucleolus" hsa03020 RNA polymerase POLR1B 698.4601829 768.3216681 628.5986978 0.818145217 -0.289571157 0.444178499 1 4.790444665 4.08810605 84172 RNA polymerase I subunit B "GO:0003677,GO:0003899,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005736,GO:0005829,GO:0006361,GO:0006362,GO:0006363,GO:0007566,GO:0009303,GO:0017126,GO:0032549,GO:0045815,GO:0046872" "DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|chromosome|nucleolus|RNA polymerase I complex|cytosol|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|embryo implantation|rRNA transcription|nucleologenesis|ribonucleoside binding|positive regulation of gene expression, epigenetic|metal ion binding" hsa03020 RNA polymerase POLR1C 344.7356577 396.8477836 292.6235317 0.737369701 -0.439539958 0.332466557 1 8.186941037 6.296843226 9533 RNA polymerase I and III subunit C "GO:0001054,GO:0001056,GO:0003677,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005736,GO:0005829,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006383,GO:0032481,GO:0045815,GO:0046983" "RNA polymerase I activity|RNA polymerase III activity|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase III|positive regulation of type I interferon production|positive regulation of gene expression, epigenetic|protein dimerization activity" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR1D 1116.5441 1094.122534 1138.965666 1.040985475 0.057949938 0.869308101 1 15.29068612 16.60303842 51082 RNA polymerase I and III subunit D "GO:0003677,GO:0003899,GO:0005515,GO:0005666,GO:0005736,GO:0006351,GO:0046983" "DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|RNA polymerase III complex|RNA polymerase I complex|transcription, DNA-templated|protein dimerization activity" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR1E 910.949206 947.9688745 873.9295375 0.921896869 -0.117322727 0.745377015 1 24.63380157 23.68807168 64425 RNA polymerase I subunit E "GO:0001179,GO:0001188,GO:0001650,GO:0003677,GO:0003899,GO:0005515,GO:0005654,GO:0005730,GO:0005736,GO:0006361,GO:0006362,GO:0006363,GO:0042790,GO:0045815" "RNA polymerase I general transcription initiation factor binding|RNA polymerase I preinitiation complex assembly|fibrillar center|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|nucleolus|RNA polymerase I complex|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|nucleolar large rRNA transcription by RNA polymerase I|positive regulation of gene expression, epigenetic" hsa03020 RNA polymerase POLR1F 835.403772 868.8023089 802.0052351 0.923115911 -0.115416283 0.75359407 1 11.3027927 10.88323305 221830 RNA polymerase I subunit F "GO:0003899,GO:0005654,GO:0005736,GO:0006361,GO:0006362,GO:0006363,GO:0045815" "DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|RNA polymerase I complex|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|positive regulation of gene expression, epigenetic" hsa03020 RNA polymerase POLR1G 284.9989917 320.726086 249.2718974 0.777211173 -0.363621455 0.450867607 1 5.756075408 4.666394372 10849 RNA polymerase I subunit G "GO:0000120,GO:0001650,GO:0003723,GO:0003899,GO:0005654,GO:0005694,GO:0005730,GO:0005736,GO:0005739,GO:0005829,GO:0006361,GO:0006362,GO:0006363,GO:0007169,GO:0009303,GO:0045815" "RNA polymerase I transcription regulator complex|fibrillar center|RNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|chromosome|nucleolus|RNA polymerase I complex|mitochondrion|cytosol|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transmembrane receptor protein tyrosine kinase signaling pathway|rRNA transcription|positive regulation of gene expression, epigenetic" POLR1H 249.6860953 230.3950048 268.9771857 1.167461013 0.223374372 0.660382424 1 16.07258156 19.5723942 30834 RNA polymerase I subunit H "GO:0003676,GO:0003899,GO:0005515,GO:0005654,GO:0005736,GO:0006139,GO:0006361,GO:0006362,GO:0006363,GO:0006379,GO:0008270,GO:0045815" "nucleic acid binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase I complex|nucleobase-containing compound metabolic process|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|mRNA cleavage|zinc ion binding|positive regulation of gene expression, epigenetic" hsa03020 RNA polymerase POLR2A 4885.574663 5061.585414 4709.563911 0.930452324 -0.103995866 0.746111306 1 37.98361906 36.86433435 5430 RNA polymerase II subunit A "GO:0000398,GO:0000974,GO:0001055,GO:0001172,GO:0003677,GO:0003723,GO:0003899,GO:0003968,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005694,GO:0005730,GO:0005737,GO:0006283,GO:0006351,GO:0006353,GO:0006355,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008022,GO:0008543,GO:0016032,GO:0016070,GO:0019900,GO:0031625,GO:0033120,GO:0035019,GO:0042795,GO:0046872,GO:0050434,GO:0060964,GO:1990841" "mRNA splicing, via spliceosome|Prp19 complex|RNA polymerase II activity|transcription, RNA-templated|DNA binding|RNA binding|DNA-directed 5'-3' RNA polymerase activity|RNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|chromosome|nucleolus|cytoplasm|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|DNA-templated transcription, termination|regulation of transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein C-terminus binding|fibroblast growth factor receptor signaling pathway|viral process|RNA metabolic process|kinase binding|ubiquitin protein ligase binding|positive regulation of RNA splicing|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|metal ion binding|positive regulation of viral transcription|regulation of gene silencing by miRNA|promoter-specific chromatin binding" "hsa03020,hsa05016" RNA polymerase|Huntington disease other POLR2B 2661.703461 2796.203693 2527.203228 0.903797973 -0.145927774 0.647447117 1 35.73501202 33.68846515 5431 RNA polymerase II subunit B "GO:0000398,GO:0000781,GO:0001055,GO:0003677,GO:0003682,GO:0003723,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016020,GO:0016070,GO:0032549,GO:0035019,GO:0042795,GO:0046872,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|chromosome, telomeric region|RNA polymerase II activity|DNA binding|chromatin binding|RNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|ribonucleoside binding|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|metal ion binding|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2C 1090.900255 1058.599075 1123.201435 1.061026276 0.085460385 0.807673242 1 30.393599 33.63753777 5432 RNA polymerase II subunit C "GO:0000398,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005829,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0035019,GO:0042795,GO:0046983,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|protein dimerization activity|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2D 822.2175092 741.9328129 902.5022056 1.216420395 0.282641911 0.439789862 1 7.45857078 9.463575219 5433 RNA polymerase II subunit D "GO:0000166,GO:0000288,GO:0000398,GO:0000932,GO:0003697,GO:0003727,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005829,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0016607,GO:0031369,GO:0031990,GO:0034402,GO:0035019,GO:0042795,GO:0045948,GO:0050434,GO:0060964" "nucleotide binding|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|mRNA splicing, via spliceosome|P-body|single-stranded DNA binding|single-stranded RNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|nuclear speck|translation initiation factor binding|mRNA export from nucleus in response to heat stress|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of translational initiation|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2E 2870.978869 3025.583742 2716.373996 0.897801624 -0.155531389 0.625472355 1 50.87488144 47.64306867 5434 "RNA polymerase II, I and III subunit E" "GO:0000398,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016032,GO:0016070,GO:0032481,GO:0035019,GO:0042795,GO:0045815,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|viral process|RNA metabolic process|positive regulation of type I interferon production|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa04623,hsa05016" RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2F 930.5005933 1004.806409 856.194778 0.852099241 -0.230906629 0.518474102 1 15.45865731 13.73971985 5435 "RNA polymerase II, I and III subunit F" "GO:0000398,GO:0001650,GO:0003677,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0032481,GO:0035019,GO:0042795,GO:0045815,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|fibrillar center|DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|RNA polymerase II, core complex|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of type I interferon production|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa04623,hsa05016" RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2G 1516.817544 1616.824858 1416.810231 0.876291717 -0.190516872 0.565605726 1 103.5227247 94.62378813 5436 RNA polymerase II subunit G "GO:0000291,GO:0000398,GO:0000932,GO:0003697,GO:0003727,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006915,GO:0008543,GO:0016070,GO:0031369,GO:0035019,GO:0042795,GO:0045948,GO:0050434,GO:0060213,GO:0060964" "nuclear-transcribed mRNA catabolic process, exonucleolytic|mRNA splicing, via spliceosome|P-body|single-stranded DNA binding|single-stranded RNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|apoptotic process|fibroblast growth factor receptor signaling pathway|RNA metabolic process|translation initiation factor binding|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of translational initiation|positive regulation of viral transcription|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2H 1343.068316 1424.99818 1261.138453 0.885010571 -0.176233407 0.601216253 1 31.84957224 29.40139874 5437 "RNA polymerase II, I and III subunit H" "GO:0000398,GO:0003697,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0032481,GO:0032993,GO:0035019,GO:0042795,GO:0045815,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|single-stranded DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|RNA polymerase II, core complex|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of type I interferon production|protein-DNA complex|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa04623,hsa05016" RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2I 469.1556007 483.1190409 455.1921604 0.942194618 -0.085903003 0.840567416 1 55.2331266 54.28204206 5438 RNA polymerase II subunit I "GO:0000398,GO:0001193,GO:0003676,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005730,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006379,GO:0008270,GO:0008543,GO:0016070,GO:0035019,GO:0042795,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter|nucleic acid binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|nucleolus|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|mRNA cleavage|zinc ion binding|fibroblast growth factor receptor signaling pathway|RNA metabolic process|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2J 1159.162848 1111.376785 1206.94891 1.085994351 0.119016598 0.730860159 1 34.63834676 39.23743879 5439 RNA polymerase II subunit J "GO:0000398,GO:0001055,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0030275,GO:0035019,GO:0042795,GO:0046983,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|RNA polymerase II activity|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|LRR domain binding|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|protein dimerization activity|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2J2 17.94260036 14.20938356 21.67581716 1.525457954 0.609242415 0.620478716 1 0.361091395 0.574557251 246721 RNA polymerase II subunit J2 "GO:0001055,GO:0003677,GO:0003899,GO:0005665,GO:0006366,GO:0046983" "RNA polymerase II activity|DNA binding|DNA-directed 5'-3' RNA polymerase activity|RNA polymerase II, core complex|transcription by RNA polymerase II|protein dimerization activity" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2J3 26.82482589 15.22433953 38.42531225 2.523939523 1.335677342 0.195015831 1 0.458963743 1.208295765 548644 RNA polymerase II subunit J3 "GO:0001055,GO:0003677,GO:0003899,GO:0005515,GO:0005665,GO:0006366,GO:0046983" "RNA polymerase II activity|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|RNA polymerase II, core complex|transcription by RNA polymerase II|protein dimerization activity" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2K 1431.557284 1311.323111 1551.791456 1.183378408 0.242911477 0.466794588 1 70.13082314 86.56623056 5440 "RNA polymerase II, I and III subunit K" "GO:0000398,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006356,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006383,GO:0008270,GO:0008543,GO:0016070,GO:0032481,GO:0035019,GO:0042795,GO:0045815,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|regulation of transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription by RNA polymerase III|zinc ion binding|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of type I interferon production|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa04623,hsa05016" RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2L 3977.119793 3913.670214 4040.569372 1.032424592 0.046036411 0.885831472 1 226.2712212 243.6708571 5441 "RNA polymerase II, I and III subunit L" "GO:0000398,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006356,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008270,GO:0008543,GO:0016070,GO:0032481,GO:0035019,GO:0042795,GO:0042797,GO:0045815,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|regulation of transcription by RNA polymerase I|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|zinc ion binding|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of type I interferon production|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|tRNA transcription by RNA polymerase III|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa04623,hsa05016" RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2M 61.29151309 47.70293051 74.88009566 1.569716888 0.650504381 0.417570696 1 0.587259393 0.961539728 81488 RNA polymerase II subunit M "GO:0003899,GO:0005622,GO:0005635,GO:0005665,GO:0016591,GO:0032774,GO:0035556,GO:0043025,GO:0051685" "DNA-directed 5'-3' RNA polymerase activity|intracellular anatomical structure|nuclear envelope|RNA polymerase II, core complex|RNA polymerase II, holoenzyme|RNA biosynthetic process|intracellular signal transduction|neuronal cell body|maintenance of ER location" POLR3A 1827.700635 1955.820151 1699.581119 0.868986403 -0.202594491 0.532928327 1 14.98568698 13.58330861 11128 RNA polymerase III subunit A "GO:0003677,GO:0003682,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006351,GO:0016020,GO:0032481,GO:0032728,GO:0045087,GO:0046872,GO:0051607" "DNA binding|chromatin binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|RNA polymerase III complex|cytosol|transcription, DNA-templated|membrane|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|metal ion binding|defense response to virus" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway other POLR3B 367.2873756 456.7301858 277.8445655 0.608334142 -0.71706412 0.107165038 1 3.605888178 2.28807563 55703 RNA polymerase III subunit B "GO:0003677,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006351,GO:0032481,GO:0032549,GO:0032728,GO:0045087,GO:0045089,GO:0046872,GO:0051607" "DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|RNA polymerase III complex|cytosol|transcription, DNA-templated|positive regulation of type I interferon production|ribonucleoside binding|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|metal ion binding|defense response to virus" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3C 599.5465133 573.4501221 625.6429045 1.091015383 0.125671443 0.750880016 1 7.73454745 8.802007045 10623 RNA polymerase III subunit C "GO:0003697,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005829,GO:0006351,GO:0006359,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607" "single-stranded DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|cytosol|transcription, DNA-templated|regulation of transcription by RNA polymerase III|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3D 646.6798611 697.2747503 596.084972 0.854878184 -0.226209238 0.557535056 1 6.618160844 5.90143301 661 RNA polymerase III subunit D "GO:0003677,GO:0003682,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006383,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607" DNA binding|chromatin binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|RNA polymerase III complex|cytosol|transcription by RNA polymerase III|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3E 641.2663501 630.2876564 652.2450438 1.034837089 0.049403667 0.901860859 1 6.52398248 7.042075899 55718 RNA polymerase III subunit E "GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006351,GO:0032481,GO:0045087,GO:0051607" "DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|RNA polymerase III complex|cytosol|transcription, DNA-templated|positive regulation of type I interferon production|innate immune response|defense response to virus" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3F 491.0986418 501.3882484 480.8090353 0.958955534 -0.060464175 0.887608951 1 11.4591814 11.46220031 10621 RNA polymerase III subunit F "GO:0003690,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005829,GO:0006359,GO:0006383,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607" double-stranded DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|cytosol|regulation of transcription by RNA polymerase III|transcription by RNA polymerase III|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3G 328.2115708 378.5785762 277.8445655 0.733915184 -0.446314749 0.332335281 1 4.066525841 3.113044574 10622 RNA polymerase III subunit G "GO:0003682,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005666,GO:0005829,GO:0006359,GO:0006383,GO:0008283,GO:0016604,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607" chromatin binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase III complex|cytosol|regulation of transcription by RNA polymerase III|transcription by RNA polymerase III|cell population proliferation|nuclear body|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway other POLR3GL 195.7840653 182.6920743 208.8760563 1.143323032 0.193233077 0.728092096 1 7.425930228 8.855962043 84265 RNA polymerase III subunit GL "GO:0005515,GO:0005634,GO:0005654,GO:0005666,GO:0005829,GO:0006383,GO:0032481" protein binding|nucleus|nucleoplasm|RNA polymerase III complex|cytosol|transcription by RNA polymerase III|positive regulation of type I interferon production "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3H 1481.628611 1838.085259 1125.171964 0.612143511 -0.708058177 0.033474051 0.820898508 17.92654226 11.44631542 171568 RNA polymerase III subunit H "GO:0003677,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005813,GO:0005829,GO:0006139,GO:0006383,GO:0006384,GO:0032481,GO:0043231,GO:0045087,GO:0051607" DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|centrosome|cytosol|nucleobase-containing compound metabolic process|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|positive regulation of type I interferon production|intracellular membrane-bounded organelle|innate immune response|defense response to virus "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3K 330.8556028 357.2645009 304.4467047 0.852160525 -0.230802872 0.617909512 1 13.18818266 11.72255546 51728 RNA polymerase III subunit K "GO:0003676,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005730,GO:0005829,GO:0006383,GO:0006386,GO:0008270,GO:0032481,GO:0042779,GO:0045087,GO:0051607" nucleic acid binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|nucleolus|cytosol|transcription by RNA polymerase III|termination of RNA polymerase III transcription|zinc ion binding|positive regulation of type I interferon production|tRNA 3'-trailer cleavage|innate immune response|defense response to virus "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLRMT 858.0594104 935.7894028 780.3294179 0.833872894 -0.262100602 0.470150357 1 12.57814012 10.94037517 5442 RNA polymerase mitochondrial "GO:0001018,GO:0003723,GO:0003899,GO:0005515,GO:0005739,GO:0005759,GO:0006390,GO:0006391,GO:0007005,GO:0032991,GO:0034245,GO:0042645,GO:0043565" mitochondrial promoter sequence-specific DNA binding|RNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|mitochondrion|mitochondrial matrix|mitochondrial transcription|transcription initiation from mitochondrial promoter|mitochondrion organization|protein-containing complex|mitochondrial DNA-directed RNA polymerase complex|mitochondrial nucleoid|sequence-specific DNA binding POM121 1399.723742 1391.504633 1407.942851 1.011813269 0.016943064 0.961908627 1 6.94127851 7.32581202 9883 POM121 transmembrane nucleoporin "GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005789,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0008139,GO:0016021,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0043657,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|nuclear pore|nucleoplasm|endoplasmic reticulum membrane|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear localization sequence binding|integral component of membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis POM121C 2412.343972 2588.137719 2236.550226 0.864154256 -0.210639231 0.509756669 1 22.34192008 20.13852678 100101267 POM121 transmembrane nucleoporin C "GO:0005515,GO:0005635,GO:0005643,GO:0005789,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0008139,GO:0016021,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0043657,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|nuclear pore|endoplasmic reticulum membrane|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear localization sequence binding|integral component of membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis POMGNT1 2432.551542 2285.680841 2579.422243 1.128513744 0.174423989 0.585240823 1 32.50819185 38.26622285 55624 "protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)" "GO:0000139,GO:0005515,GO:0006493,GO:0008375,GO:0016021,GO:0016266,GO:0018215,GO:0030145,GO:0030173,GO:0047223" "Golgi membrane|protein binding|protein O-linked glycosylation|acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|manganese ion binding|integral component of Golgi membrane|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity" hsa00515 Mannose type O-glycan biosynthesis POMGNT2 972.9830079 1046.419603 899.5464123 0.859642164 -0.218191849 0.538598966 1 19.10506899 17.1309816 84892 "protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)" "GO:0001764,GO:0005515,GO:0005783,GO:0005789,GO:0006493,GO:0008375,GO:0016021,GO:0016757,GO:0018215,GO:0035269,GO:0097363" "neuron migration|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein O-linked glycosylation|acetylglucosaminyltransferase activity|integral component of membrane|transferase activity, transferring glycosyl groups|protein phosphopantetheinylation|protein O-linked mannosylation|protein O-GlcNAc transferase activity" hsa00515 Mannose type O-glycan biosynthesis POMK 70.09678813 77.1366536 63.05692266 0.817470291 -0.290761795 0.714558541 1 2.091380826 1.783286123 84197 protein O-mannose kinase "GO:0004672,GO:0005515,GO:0005524,GO:0005789,GO:0006468,GO:0006493,GO:0007420,GO:0016021,GO:0016773,GO:0019200,GO:0046835" "protein kinase activity|protein binding|ATP binding|endoplasmic reticulum membrane|protein phosphorylation|protein O-linked glycosylation|brain development|integral component of membrane|phosphotransferase activity, alcohol group as acceptor|carbohydrate kinase activity|carbohydrate phosphorylation" hsa00515 Mannose type O-glycan biosynthesis POMP 1157.721324 1214.902294 1100.540353 0.905867376 -0.142628248 0.679717798 1 45.9869322 43.45252194 51371 proteasome maturation protein "GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0016607,GO:0031090,GO:0043248" protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|nuclear speck|organelle membrane|proteasome assembly hsa03050 Proteasome POMT1 872.6723515 958.1184341 787.2262688 0.821637744 -0.283425638 0.433145424 1 14.90335339 12.77262939 10585 protein O-mannosyltransferase 1 "GO:0000030,GO:0001669,GO:0004169,GO:0005783,GO:0005789,GO:0005975,GO:0006493,GO:0007275,GO:0016021,GO:0016529,GO:0030198,GO:0035269,GO:0046872,GO:1904100" mannosyltransferase activity|acrosomal vesicle|dolichyl-phosphate-mannose-protein mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|carbohydrate metabolic process|protein O-linked glycosylation|multicellular organism development|integral component of membrane|sarcoplasmic reticulum|extracellular matrix organization|protein O-linked mannosylation|metal ion binding|positive regulation of protein O-linked glycosylation "hsa00514,hsa00515" Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis POMT2 872.5387395 948.9838304 796.0936486 0.838890635 -0.253445353 0.483597503 1 9.496677178 8.309845539 29954 protein O-mannosyltransferase 2 "GO:0000030,GO:0004169,GO:0005654,GO:0005730,GO:0005789,GO:0005829,GO:0006493,GO:0016021,GO:0035269,GO:0046872,GO:0071712,GO:1904100" mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|nucleoplasm|nucleolus|endoplasmic reticulum membrane|cytosol|protein O-linked glycosylation|integral component of membrane|protein O-linked mannosylation|metal ion binding|ER-associated misfolded protein catabolic process|positive regulation of protein O-linked glycosylation "hsa00514,hsa00515" Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis POMZP3 372.8777983 367.4140606 378.341536 1.029741582 0.042282332 0.930130303 1 12.17815838 13.08054376 22932 POM121 and ZP3 fusion "GO:0003674,GO:0005654,GO:0007339,GO:0008150,GO:0031012,GO:0031965,GO:0032190,GO:0035803,GO:2000344" molecular_function|nucleoplasm|binding of sperm to zona pellucida|biological_process|extracellular matrix|nuclear membrane|acrosin binding|egg coat formation|positive regulation of acrosome reaction PON2 1576.229087 1468.641286 1683.816888 1.146513382 0.197253194 0.550044839 1 44.27470244 52.94814004 5445 paraoxonase 2 "GO:0004064,GO:0005576,GO:0005886,GO:0009636,GO:0019372,GO:0019439,GO:0042802,GO:0046872,GO:0102007" arylesterase activity|extracellular region|plasma membrane|response to toxic substance|lipoxygenase pathway|aromatic compound catabolic process|identical protein binding|metal ion binding|acyl-L-homoserine-lactone lactonohydrolase activity POP1 919.6599631 1038.299956 801.0199707 0.771472604 -0.374313169 0.295482679 1 10.88066001 8.755716241 10940 "POP1 homolog, ribonuclease P/MRP subunit" "GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005515,GO:0005615,GO:0005654,GO:0005655,GO:0005730,GO:0008033,GO:0016078,GO:0030681,GO:0033204,GO:0090502" "ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|protein binding|extracellular space|nucleoplasm|nucleolar ribonuclease P complex|nucleolus|tRNA processing|tRNA catabolic process|multimeric ribonuclease P complex|ribonuclease P RNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport POP4 552.850374 580.5548139 525.145934 0.904558745 -0.144713895 0.719451472 1 11.50354196 10.8538618 10775 "POP4 homolog, ribonuclease P/MRP subunit" "GO:0000171,GO:0000172,GO:0001682,GO:0004526,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030677,GO:0030681,GO:0033204,GO:0090502" "ribonuclease MRP activity|ribonuclease MRP complex|tRNA 5'-leader removal|ribonuclease P activity|protein binding|nucleoplasm|nucleolus|rRNA processing|ribonuclease P complex|multimeric ribonuclease P complex|ribonuclease P RNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport POP5 445.5092547 483.1190409 407.8994685 0.844304268 -0.244165087 0.563885464 1 20.5615757 18.10803426 51367 "POP5 homolog, ribonuclease P/MRP subunit" "GO:0000172,GO:0001682,GO:0004526,GO:0005515,GO:0005654,GO:0005655,GO:0005730,GO:0006364,GO:0008033,GO:0030681,GO:0033204,GO:0090502" "ribonuclease MRP complex|tRNA 5'-leader removal|ribonuclease P activity|protein binding|nucleoplasm|nucleolar ribonuclease P complex|nucleolus|rRNA processing|tRNA processing|multimeric ribonuclease P complex|ribonuclease P RNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport POP7 654.9479666 723.6636055 586.2323278 0.810089555 -0.303846689 0.428532431 1 43.11883375 36.43476459 10248 "POP7 homolog, ribonuclease P/MRP subunit" "GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008033,GO:0030681,GO:0033204,GO:0043231,GO:0090502" "ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|tRNA processing|multimeric ribonuclease P complex|ribonuclease P RNA binding|intracellular membrane-bounded organelle|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport POPDC3 301.7457652 354.219633 249.2718974 0.703721291 -0.506923933 0.283257005 1 3.707372349 2.721340136 64208 popeye domain containing 3 "GO:0003674,GO:0007507,GO:0007519,GO:0008150,GO:0016021,GO:0030552,GO:0042383,GO:0042391,GO:0051146" molecular_function|heart development|skeletal muscle tissue development|biological_process|integral component of membrane|cAMP binding|sarcolemma|regulation of membrane potential|striated muscle cell differentiation POR 1306.83226 1305.233375 1308.431145 1.00244996 0.003530223 0.994245269 1 20.79442148 21.74330085 5447 cytochrome p450 oxidoreductase "GO:0003958,GO:0005515,GO:0005789,GO:0005829,GO:0006805,GO:0009725,GO:0010181,GO:0016020,GO:0016021,GO:0016491,GO:0016709,GO:0032770,GO:0043231,GO:0050660,GO:0050661,GO:0055114,GO:0090346" "NADPH-hemoprotein reductase activity|protein binding|endoplasmic reticulum membrane|cytosol|xenobiotic metabolic process|response to hormone|FMN binding|membrane|integral component of membrane|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|positive regulation of monooxygenase activity|intracellular membrane-bounded organelle|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process|cellular organofluorine metabolic process" PORCN 549.9985011 587.6595057 512.3374966 0.871827124 -0.197886006 0.622118 1 13.32865241 12.12083526 64840 porcupine O-acyltransferase "GO:0005783,GO:0005789,GO:0006497,GO:0009100,GO:0016020,GO:0016055,GO:0016746,GO:0017147,GO:0018345,GO:0030176,GO:0030258,GO:0032281,GO:0045234,GO:0060070,GO:0061355,GO:0098978,GO:0099072,GO:1990698" "endoplasmic reticulum|endoplasmic reticulum membrane|protein lipidation|glycoprotein metabolic process|membrane|Wnt signaling pathway|transferase activity, transferring acyl groups|Wnt-protein binding|protein palmitoylation|integral component of endoplasmic reticulum membrane|lipid modification|AMPA glutamate receptor complex|protein palmitoleylation|canonical Wnt signaling pathway|Wnt protein secretion|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels|palmitoleoyltransferase activity" hsa04310 Wnt signaling pathway POT1 685.9595474 654.6465996 717.2724952 1.095663669 0.131805009 0.730766616 1 8.449424265 9.656512533 25913 protection of telomeres 1 "GO:0000781,GO:0000783,GO:0005515,GO:0005654,GO:0007004,GO:0010521,GO:0016233,GO:0017151,GO:0032202,GO:0032210,GO:0032211,GO:0032212,GO:0032508,GO:0042162,GO:0043047,GO:0051096,GO:0051973,GO:0051974,GO:0060383,GO:0061820,GO:0061821,GO:0061849,GO:0070187,GO:0070200,GO:0098505,GO:1905773,GO:1905774,GO:1905776,GO:1990955,GO:2001032" "chromosome, telomeric region|nuclear telomere cap complex|protein binding|nucleoplasm|telomere maintenance via telomerase|telomerase inhibitor activity|telomere capping|DEAD/H-box RNA helicase binding|telomere assembly|regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|DNA duplex unwinding|telomeric DNA binding|single-stranded telomeric DNA binding|positive regulation of helicase activity|positive regulation of telomerase activity|negative regulation of telomerase activity|positive regulation of DNA strand elongation|telomeric D-loop disassembly|telomeric D-loop binding|telomeric G-quadruplex DNA binding|shelterin complex|establishment of protein localization to telomere|G-rich strand telomeric DNA binding|8-hydroxy-2'-deoxyguanosine DNA binding|regulation of DNA helicase activity|positive regulation of DNA helicase activity|G-rich single-stranded DNA binding|regulation of double-strand break repair via nonhomologous end joining" POTEJ 14.53871223 17.25425146 11.823173 0.68523245 -0.545334622 0.691269147 1 0.226919493 0.162190591 653781 POTE ankyrin domain family member J "GO:0001895,GO:0005615,GO:0070062" retina homeostasis|extracellular space|extracellular exosome POU2F1 748.676255 799.7853031 697.5672069 0.87219308 -0.197280551 0.59770294 1 2.735618567 2.488766253 5451 POU class 2 homeobox 1 "GO:0000785,GO:0000978,GO:0000979,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0006357,GO:0019221,GO:0042795,GO:0043231,GO:0043565,GO:0045892,GO:0045944,GO:0090575" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|regulation of transcription by RNA polymerase II|cytokine-mediated signaling pathway|snRNA transcription by RNA polymerase II|intracellular membrane-bounded organelle|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulator complex" hsa05168 Herpes simplex virus 1 infection POU POU2F2 1071.807849 864.7424851 1278.873213 1.47890642 0.564530767 0.105415933 1 4.620335082 7.127383004 5452 POU class 2 homeobox 2 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006959,GO:0032755,GO:0042795,GO:0043231,GO:0043565,GO:0045944,GO:0098586,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|humoral immune response|positive regulation of interleukin-6 production|snRNA transcription by RNA polymerase II|intracellular membrane-bounded organelle|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|cellular response to virus|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection POU POU5F1 8.015727316 9.134603715 6.896850916 0.755024644 -0.405404361 0.864587159 1 0.167803937 0.132153662 5460 POU class 5 homeobox 1 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001714,GO:0001824,GO:0003677,GO:0003700,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006355,GO:0006357,GO:0009611,GO:0009653,GO:0009786,GO:0010468,GO:0031625,GO:0035019,GO:0035198,GO:0043565,GO:0045944,GO:0060965,GO:1902894,GO:1990837" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|endodermal cell fate specification|blastocyst development|DNA binding|DNA-binding transcription factor activity|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|response to wounding|anatomical structure morphogenesis|regulation of asymmetric cell division|regulation of gene expression|ubiquitin protein ligase binding|somatic stem cell population maintenance|miRNA binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|negative regulation of gene silencing by miRNA|negative regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells POU POU6F1 397.9453794 329.8606897 466.030069 1.412808751 0.498566184 0.251303103 1 1.637870613 2.413675582 5463 POU class 6 homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0007507,GO:0007517,GO:0043565,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|heart development|muscle organ development|sequence-specific DNA binding|sequence-specific double-stranded DNA binding" PPA1 3099.973174 3087.496056 3112.450292 1.008082354 0.011613503 0.971980336 1 121.030018 127.2638449 5464 inorganic pyrophosphatase 1 "GO:0000287,GO:0004427,GO:0005737,GO:0005829,GO:0006418,GO:0006796,GO:0070062,GO:0071344" magnesium ion binding|inorganic diphosphatase activity|cytoplasm|cytosol|tRNA aminoacylation for protein translation|phosphate-containing compound metabolic process|extracellular exosome|diphosphate metabolic process hsa00190 Oxidative phosphorylation PPA2 736.3213557 729.7533413 742.8893701 1.018000642 0.025738472 0.948938369 1 22.19785725 23.5708387 27068 inorganic pyrophosphatase 2 "GO:0000287,GO:0004427,GO:0004722,GO:0005759,GO:0005829,GO:0006418,GO:0006470,GO:0006796,GO:0051881,GO:0071344" magnesium ion binding|inorganic diphosphatase activity|protein serine/threonine phosphatase activity|mitochondrial matrix|cytosol|tRNA aminoacylation for protein translation|protein dephosphorylation|phosphate-containing compound metabolic process|regulation of mitochondrial membrane potential|diphosphate metabolic process hsa00190 Oxidative phosphorylation PPAN 80.94682088 111.6451565 50.24848524 0.450073132 -1.151768653 0.114847021 1 2.316441343 1.087477611 56342 peter pan homolog "GO:0000027,GO:0003723,GO:0005634,GO:0005730,GO:0019843,GO:0030687" "ribosomal large subunit assembly|RNA binding|nucleus|nucleolus|rRNA binding|preribosome, large subunit precursor" PPARA 362.8470048 355.2345889 370.4594206 1.042858528 0.060543459 0.898063498 1 4.06860668 4.425751595 5465 peroxisome proliferator activated receptor alpha "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001103,GO:0001223,GO:0001227,GO:0001228,GO:0001666,GO:0003677,GO:0003700,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006367,GO:0006631,GO:0007507,GO:0008134,GO:0008144,GO:0008270,GO:0008289,GO:0008544,GO:0009267,GO:0009755,GO:0010565,GO:0010745,GO:0010876,GO:0010887,GO:0010891,GO:0019216,GO:0019217,GO:0019902,GO:0019904,GO:0030154,GO:0030512,GO:0030522,GO:0031624,GO:0032000,GO:0032091,GO:0032099,GO:0032868,GO:0032922,GO:0033993,GO:0035095,GO:0042060,GO:0042157,GO:0042752,GO:0043401,GO:0043565,GO:0044877,GO:0045070,GO:0045471,GO:0045722,GO:0045776,GO:0045820,GO:0045893,GO:0045923,GO:0045944,GO:0046321,GO:0046889,GO:0050728,GO:0051525,GO:0051898,GO:0061052,GO:0070166,GO:0097371,GO:1900016,GO:1901215,GO:1902894,GO:1903038,GO:1903427,GO:1903944,GO:2000191,GO:2000272,GO:2001171" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|transcription coactivator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|DNA binding|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|fatty acid metabolic process|heart development|transcription factor binding|drug binding|zinc ion binding|lipid binding|epidermis development|cellular response to starvation|hormone-mediated signaling pathway|regulation of cellular ketone metabolic process|negative regulation of macrophage derived foam cell differentiation|lipid localization|negative regulation of cholesterol storage|negative regulation of sequestering of triglyceride|regulation of lipid metabolic process|regulation of fatty acid metabolic process|phosphatase binding|protein domain specific binding|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|intracellular receptor signaling pathway|ubiquitin conjugating enzyme binding|positive regulation of fatty acid beta-oxidation|negative regulation of protein binding|negative regulation of appetite|response to insulin|circadian regulation of gene expression|response to lipid|behavioral response to nicotine|wound healing|lipoprotein metabolic process|regulation of circadian rhythm|steroid hormone mediated signaling pathway|sequence-specific DNA binding|protein-containing complex binding|positive regulation of viral genome replication|response to ethanol|positive regulation of gluconeogenesis|negative regulation of blood pressure|negative regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of fatty acid metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of fatty acid oxidation|positive regulation of lipid biosynthetic process|negative regulation of inflammatory response|NFAT protein binding|negative regulation of protein kinase B signaling|negative regulation of cell growth involved in cardiac muscle cell development|enamel mineralization|MDM2/MDM4 family protein binding|negative regulation of cytokine production involved in inflammatory response|negative regulation of neuron death|negative regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of leukocyte cell-cell adhesion|negative regulation of reactive oxygen species biosynthetic process|negative regulation of hepatocyte apoptotic process|regulation of fatty acid transport|negative regulation of signaling receptor activity|positive regulation of ATP biosynthetic process" "hsa03320,hsa04024,hsa04920,hsa04922,hsa04931,hsa04932,hsa05160" PPAR signaling pathway|cAMP signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hepatitis C PPARD 512.5990313 455.7152298 569.4828328 1.24964626 0.321519767 0.429378377 1 5.247923766 6.840542434 5467 peroxisome proliferator activated receptor delta "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001103,GO:0001223,GO:0001227,GO:0003677,GO:0003700,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006006,GO:0006029,GO:0006091,GO:0006357,GO:0006367,GO:0006629,GO:0006631,GO:0006635,GO:0006776,GO:0006915,GO:0007507,GO:0007566,GO:0008134,GO:0008144,GO:0008203,GO:0008270,GO:0008283,GO:0008289,GO:0008366,GO:0008654,GO:0009062,GO:0009749,GO:0009755,GO:0010887,GO:0014068,GO:0014823,GO:0014842,GO:0014912,GO:0015908,GO:0019216,GO:0030154,GO:0030308,GO:0030522,GO:0031589,GO:0032966,GO:0033189,GO:0033993,GO:0035774,GO:0042060,GO:0043066,GO:0043401,GO:0043415,GO:0043616,GO:0045600,GO:0045662,GO:0045684,GO:0045892,GO:0045893,GO:0045923,GO:0045944,GO:0046321,GO:0046697,GO:0048662,GO:0050680,GO:0050728,GO:0051059,GO:0051546,GO:0060612,GO:0070539,GO:0071222,GO:0071456,GO:0097190,GO:1902894,GO:1904659,GO:1990837,GO:2000288" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|transcription coactivator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|glucose metabolic process|proteoglycan metabolic process|generation of precursor metabolites and energy|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|lipid metabolic process|fatty acid metabolic process|fatty acid beta-oxidation|vitamin A metabolic process|apoptotic process|heart development|embryo implantation|transcription factor binding|drug binding|cholesterol metabolic process|zinc ion binding|cell population proliferation|lipid binding|axon ensheathment|phospholipid biosynthetic process|fatty acid catabolic process|response to glucose|hormone-mediated signaling pathway|negative regulation of cholesterol storage|positive regulation of phosphatidylinositol 3-kinase signaling|response to activity|regulation of skeletal muscle satellite cell proliferation|negative regulation of smooth muscle cell migration|fatty acid transport|regulation of lipid metabolic process|cell differentiation|negative regulation of cell growth|intracellular receptor signaling pathway|cell-substrate adhesion|negative regulation of collagen biosynthetic process|response to vitamin A|response to lipid|positive regulation of insulin secretion involved in cellular response to glucose stimulus|wound healing|negative regulation of apoptotic process|steroid hormone mediated signaling pathway|positive regulation of skeletal muscle tissue regeneration|keratinocyte proliferation|positive regulation of fat cell differentiation|negative regulation of myoblast differentiation|positive regulation of epidermis development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of fatty acid metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of fatty acid oxidation|decidualization|negative regulation of smooth muscle cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of inflammatory response|NF-kappaB binding|keratinocyte migration|adipose tissue development|linoleic acid binding|cellular response to lipopolysaccharide|cellular response to hypoxia|apoptotic signaling pathway|negative regulation of pri-miRNA transcription by RNA polymerase II|glucose transmembrane transport|sequence-specific double-stranded DNA binding|positive regulation of myoblast proliferation" "hsa03320,hsa04310,hsa05200,hsa05221" PPAR signaling pathway|Wnt signaling pathway|Pathways in cancer|Acute myeloid leukemia PPARG 511.3235323 536.9117073 485.7353574 0.904683863 -0.144514357 0.725208494 1 3.844032211 3.627436275 5468 peroxisome proliferator activated receptor gamma "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001103,GO:0001227,GO:0001890,GO:0002674,GO:0003677,GO:0003682,GO:0003690,GO:0003700,GO:0004879,GO:0004955,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006367,GO:0006629,GO:0006631,GO:0006919,GO:0007165,GO:0007186,GO:0007507,GO:0007584,GO:0008022,GO:0008134,GO:0008217,GO:0008270,GO:0009409,GO:0009612,GO:0009755,GO:0010742,GO:0010745,GO:0010887,GO:0010891,GO:0015909,GO:0016525,GO:0019216,GO:0019395,GO:0019899,GO:0019903,GO:0030154,GO:0030224,GO:0030308,GO:0030331,GO:0030514,GO:0030855,GO:0031000,GO:0031100,GO:0032869,GO:0032966,GO:0033189,GO:0033613,GO:0033993,GO:0035357,GO:0035902,GO:0042277,GO:0042493,GO:0042593,GO:0042594,GO:0042752,GO:0042802,GO:0042953,GO:0043231,GO:0043235,GO:0043388,GO:0043537,GO:0043565,GO:0043621,GO:0043627,GO:0045087,GO:0045165,GO:0045600,GO:0045668,GO:0045892,GO:0045893,GO:0045923,GO:0045944,GO:0046321,GO:0046965,GO:0048384,GO:0048469,GO:0048471,GO:0048511,GO:0048662,GO:0048714,GO:0050544,GO:0050692,GO:0050693,GO:0050728,GO:0050872,GO:0051091,GO:0051393,GO:0051974,GO:0055088,GO:0060100,GO:0060336,GO:0060694,GO:0060965,GO:0070888,GO:0071300,GO:0071306,GO:0071380,GO:0071404,GO:0071455,GO:0090575,GO:1901558,GO:1902895,GO:1904706,GO:1905461,GO:1905563,GO:1905599,GO:2000230,GO:2000272" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|placenta development|negative regulation of acute inflammatory response|DNA binding|chromatin binding|double-stranded DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|prostaglandin receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|lipid metabolic process|fatty acid metabolic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|G protein-coupled receptor signaling pathway|heart development|response to nutrient|protein C-terminus binding|transcription factor binding|regulation of blood pressure|zinc ion binding|response to cold|response to mechanical stimulus|hormone-mediated signaling pathway|macrophage derived foam cell differentiation|negative regulation of macrophage derived foam cell differentiation|negative regulation of cholesterol storage|negative regulation of sequestering of triglyceride|long-chain fatty acid transport|negative regulation of angiogenesis|regulation of lipid metabolic process|fatty acid oxidation|enzyme binding|protein phosphatase binding|cell differentiation|monocyte differentiation|negative regulation of cell growth|estrogen receptor binding|negative regulation of BMP signaling pathway|epithelial cell differentiation|response to caffeine|animal organ regeneration|cellular response to insulin stimulus|negative regulation of collagen biosynthetic process|response to vitamin A|activating transcription factor binding|response to lipid|peroxisome proliferator activated receptor signaling pathway|response to immobilization stress|peptide binding|response to drug|glucose homeostasis|response to starvation|regulation of circadian rhythm|identical protein binding|lipoprotein transport|intracellular membrane-bounded organelle|receptor complex|positive regulation of DNA binding|negative regulation of blood vessel endothelial cell migration|sequence-specific DNA binding|protein self-association|response to estrogen|innate immune response|cell fate commitment|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of fatty acid metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of fatty acid oxidation|retinoid X receptor binding|retinoic acid receptor signaling pathway|cell maturation|perinuclear region of cytoplasm|rhythmic process|negative regulation of smooth muscle cell proliferation|positive regulation of oligodendrocyte differentiation|arachidonic acid binding|DNA binding domain binding|LBD domain binding|negative regulation of inflammatory response|white fat cell differentiation|positive regulation of DNA-binding transcription factor activity|alpha-actinin binding|negative regulation of telomerase activity|lipid homeostasis|positive regulation of phagocytosis, engulfment|negative regulation of interferon-gamma-mediated signaling pathway|regulation of cholesterol transporter activity|negative regulation of gene silencing by miRNA|E-box binding|cellular response to retinoic acid|cellular response to vitamin E|cellular response to prostaglandin E stimulus|cellular response to low-density lipoprotein particle stimulus|cellular response to hyperoxia|RNA polymerase II transcription regulator complex|response to metformin|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell apoptotic process|negative regulation of vascular endothelial cell proliferation|positive regulation of low-density lipoprotein receptor activity|negative regulation of pancreatic stellate cell proliferation|negative regulation of signaling receptor activity" "hsa03320,hsa04152,hsa04211,hsa04380,hsa04714,hsa05016,hsa05200,hsa05202,hsa05216" PPAR signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Osteoclast differentiation|Thermogenesis|Huntington disease|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer Cnucl_rcpt PPARGC1A 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.023146586 0.00468747 10891 PPARG coactivator 1 alpha "GO:0000302,GO:0000422,GO:0000785,GO:0001659,GO:0001678,GO:0001933,GO:0002021,GO:0002931,GO:0003677,GO:0003712,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006012,GO:0006094,GO:0006355,GO:0006367,GO:0006397,GO:0007005,GO:0007568,GO:0007586,GO:0007623,GO:0008134,GO:0008209,GO:0008380,GO:0009409,GO:0010628,GO:0010822,GO:0014732,GO:0014850,GO:0014878,GO:0014912,GO:0016605,GO:0016922,GO:0019395,GO:0021549,GO:0022626,GO:0022904,GO:0030331,GO:0030374,GO:0030900,GO:0031490,GO:0031625,GO:0032922,GO:0034599,GO:0035066,GO:0035865,GO:0042493,GO:0042594,GO:0042752,GO:0042975,GO:0043014,GO:0043025,GO:0043201,GO:0043231,GO:0043524,GO:0043565,GO:0045333,GO:0045722,GO:0045820,GO:0045893,GO:0045944,GO:0046321,GO:0048661,GO:0048662,GO:0050821,GO:0050873,GO:0051091,GO:0051552,GO:0060612,GO:0065003,GO:0071222,GO:0071250,GO:0071313,GO:0071332,GO:0071333,GO:0071354,GO:0071356,GO:0071372,GO:0071392,GO:0071456,GO:0071560,GO:0071871,GO:0071873,GO:0090258,GO:0097009,GO:0097067,GO:0097440,GO:0120162,GO:1901215,GO:1901558,GO:1901857,GO:1901860,GO:1901863,GO:1904635,GO:1904637,GO:1904639,GO:1904640,GO:1990841,GO:1990843,GO:1990844,GO:1990845,GO:2000184,GO:2000272,GO:2000310,GO:2001171" "response to reactive oxygen species|autophagy of mitochondrion|chromatin|temperature homeostasis|cellular glucose homeostasis|negative regulation of protein phosphorylation|response to dietary excess|response to ischemia|DNA binding|transcription coregulator activity|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|galactose metabolic process|gluconeogenesis|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|mRNA processing|mitochondrion organization|aging|digestion|circadian rhythm|transcription factor binding|androgen metabolic process|RNA splicing|response to cold|positive regulation of gene expression|positive regulation of mitochondrion organization|skeletal muscle atrophy|response to muscle activity|response to electrical stimulus involved in regulation of muscle adaptation|negative regulation of smooth muscle cell migration|PML body|nuclear receptor binding|fatty acid oxidation|cerebellum development|cytosolic ribosome|respiratory electron transport chain|estrogen receptor binding|nuclear receptor coactivator activity|forebrain development|chromatin DNA binding|ubiquitin protein ligase binding|circadian regulation of gene expression|cellular response to oxidative stress|positive regulation of histone acetylation|cellular response to potassium ion|response to drug|response to starvation|regulation of circadian rhythm|peroxisome proliferator activated receptor binding|alpha-tubulin binding|neuronal cell body|response to leucine|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|sequence-specific DNA binding|cellular respiration|positive regulation of gluconeogenesis|negative regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of fatty acid oxidation|positive regulation of smooth muscle cell proliferation|negative regulation of smooth muscle cell proliferation|protein stabilization|brown fat cell differentiation|positive regulation of DNA-binding transcription factor activity|flavone metabolic process|adipose tissue development|protein-containing complex assembly|cellular response to lipopolysaccharide|cellular response to nitrite|cellular response to caffeine|cellular response to fructose stimulus|cellular response to glucose stimulus|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to follicle-stimulating hormone stimulus|cellular response to estradiol stimulus|cellular response to hypoxia|cellular response to transforming growth factor beta stimulus|response to epinephrine|response to norepinephrine|negative regulation of mitochondrial fission|energy homeostasis|cellular response to thyroid hormone stimulus|apical dendrite|positive regulation of cold-induced thermogenesis|negative regulation of neuron death|response to metformin|positive regulation of cellular respiration|positive regulation of mitochondrial DNA metabolic process|positive regulation of muscle tissue development|positive regulation of glomerular visceral epithelial cell apoptotic process|cellular response to ionomycin|cellular response to resveratrol|response to methionine|promoter-specific chromatin binding|subsarcolemmal mitochondrion|interfibrillar mitochondrion|adaptive thermogenesis|positive regulation of progesterone biosynthetic process|negative regulation of signaling receptor activity|regulation of NMDA receptor activity|positive regulation of ATP biosynthetic process" "hsa04152,hsa04211,hsa04371,hsa04714,hsa04910,hsa04920,hsa04922,hsa04931,hsa05016" AMPK signaling pathway|Longevity regulating pathway|Apelin signaling pathway|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Huntington disease other PPARGC1B 101.1568656 146.1536594 56.16007174 0.384253613 -1.379869269 0.043188007 0.94601832 0.564921564 0.226423783 133522 PPARG coactivator 1 beta "GO:0001503,GO:0003712,GO:0003723,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006355,GO:0006390,GO:0007015,GO:0008134,GO:0010694,GO:0016592,GO:0030331,GO:0030374,GO:0030520,GO:0034614,GO:0042327,GO:0045672,GO:0045780,GO:0045892,GO:0045944,GO:0050682,GO:0051091,GO:0051384,GO:0051591,GO:0060346,GO:0120162" "ossification|transcription coregulator activity|RNA binding|nucleus|nucleoplasm|mitochondrion|cytosol|regulation of transcription, DNA-templated|mitochondrial transcription|actin filament organization|transcription factor binding|positive regulation of alkaline phosphatase activity|mediator complex|estrogen receptor binding|nuclear receptor coactivator activity|intracellular estrogen receptor signaling pathway|cellular response to reactive oxygen species|positive regulation of phosphorylation|positive regulation of osteoclast differentiation|positive regulation of bone resorption|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|AF-2 domain binding|positive regulation of DNA-binding transcription factor activity|response to glucocorticoid|response to cAMP|bone trabecula formation|positive regulation of cold-induced thermogenesis" hsa04931 Insulin resistance PPAT 536.160262 584.6146378 487.7058862 0.834234818 -0.261474568 0.51633006 1 8.041463609 6.997442568 5471 phosphoribosyl pyrophosphate amidotransferase "GO:0000082,GO:0001822,GO:0004044,GO:0005829,GO:0006164,GO:0006189,GO:0006543,GO:0007595,GO:0009113,GO:0009116,GO:0009168,GO:0031100,GO:0032869,GO:0035690,GO:0042802,GO:0046872,GO:0051539,GO:0060135" "G1/S transition of mitotic cell cycle|kidney development|amidophosphoribosyltransferase activity|cytosol|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|glutamine catabolic process|lactation|purine nucleobase biosynthetic process|nucleoside metabolic process|purine ribonucleoside monophosphate biosynthetic process|animal organ regeneration|cellular response to insulin stimulus|cellular response to drug|identical protein binding|metal ion binding|4 iron, 4 sulfur cluster binding|maternal process involved in female pregnancy" "hsa00230,hsa00250" "Purine metabolism|Alanine, aspartate and glutamate metabolism" PPCDC 353.3385351 345.0850292 361.5920409 1.047834621 0.067411035 0.886832507 1 3.241346318 3.542697808 60490 phosphopantothenoylcysteine decarboxylase "GO:0004633,GO:0005515,GO:0005829,GO:0010181,GO:0015937,GO:0042802,GO:0071513" phosphopantothenoylcysteine decarboxylase activity|protein binding|cytosol|FMN binding|coenzyme A biosynthetic process|identical protein binding|phosphopantothenoylcysteine decarboxylase complex hsa00770 Pantothenate and CoA biosynthesis PPCS 316.1090497 325.8008658 306.4172335 0.940504663 -0.088492998 0.855216501 1 7.386152417 7.245946917 79717 phosphopantothenoylcysteine synthetase "GO:0003015,GO:0004632,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006085,GO:0015937,GO:0042802,GO:0042803" heart process|phosphopantothenate--cysteine ligase activity|ATP binding|nucleus|cytoplasm|cytosol|acetyl-CoA biosynthetic process|coenzyme A biosynthetic process|identical protein binding|protein homodimerization activity hsa00770 Pantothenate and CoA biosynthesis PPDPF 2740.586719 2766.76997 2714.403468 0.981073055 -0.027567525 0.932171156 1 169.4403124 173.3939825 79144 pancreatic progenitor cell differentiation and proliferation factor "GO:0007275,GO:0030154" multicellular organism development|cell differentiation PPFIA1 1792.6995 1886.803145 1698.595854 0.900250701 -0.151601277 0.641768169 1 14.7400776 13.84137286 8500 PTPRF interacting protein alpha 1 "GO:0005515,GO:0005737,GO:0005829,GO:0005925,GO:0007160,GO:0007165,GO:0007269,GO:0014047,GO:0048786,GO:0050808,GO:0051497,GO:1903077" protein binding|cytoplasm|cytosol|focal adhesion|cell-matrix adhesion|signal transduction|neurotransmitter secretion|glutamate secretion|presynaptic active zone|synapse organization|negative regulation of stress fiber assembly|negative regulation of protein localization to plasma membrane PPFIA3 251.9832312 252.7240361 251.2424262 0.99413744 -0.008482776 0.995540124 1 2.70147338 2.801322129 8541 PTPRF interacting protein alpha 3 "GO:0001669,GO:0005515,GO:0005829,GO:0007269,GO:0014047,GO:0016081,GO:0048172,GO:0048786,GO:0050808,GO:0098831,GO:0098875,GO:0098978" acrosomal vesicle|protein binding|cytosol|neurotransmitter secretion|glutamate secretion|synaptic vesicle docking|regulation of short-term neuronal synaptic plasticity|presynaptic active zone|synapse organization|presynaptic active zone cytoplasmic component|epididymosome|glutamatergic synapse PPFIA4 176.8898514 305.5017465 48.27795641 0.158028414 -2.661744114 9.16E-06 0.002388633 2.377471683 0.391892059 8497 PTPRF interacting protein alpha 4 "GO:0005515,GO:0005829,GO:0007269,GO:0009986,GO:0014047,GO:0045202,GO:0048786,GO:0050808" protein binding|cytosol|neurotransmitter secretion|cell surface|glutamate secretion|synapse|presynaptic active zone|synapse organization PPFIBP1 2079.768981 2079.644779 2079.893183 1.000119445 0.000172313 1 1 17.37490457 18.12550975 8496 PPFIA binding protein 1 "GO:0005515,GO:0005829,GO:0005886,GO:0005925,GO:0007155,GO:0007528,GO:0045296,GO:0048786,GO:0050808" protein binding|cytosol|plasma membrane|focal adhesion|cell adhesion|neuromuscular junction development|cadherin binding|presynaptic active zone|synapse organization PPHLN1 1182.432606 1152.98998 1211.875232 1.051071781 0.071861199 0.836028832 1 11.99319675 13.14871357 51535 periphilin 1 "GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005794,GO:0005829,GO:0031424,GO:0045814,GO:0045892,GO:0090309,GO:0097355" "RNA binding|protein binding|nucleoplasm|chromosome|Golgi apparatus|cytosol|keratinization|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|positive regulation of DNA methylation-dependent heterochromatin assembly|protein localization to heterochromatin" PPIA 26752.63638 26387.84022 27117.43254 1.027648808 0.039347317 0.917827381 1 1059.834272 1136.053049 5478 peptidylprolyl isomerase A "GO:0000187,GO:0000413,GO:0001933,GO:0001934,GO:0003723,GO:0003755,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0006278,GO:0006457,GO:0006469,GO:0006915,GO:0016018,GO:0016020,GO:0019058,GO:0019061,GO:0019064,GO:0019068,GO:0019076,GO:0030168,GO:0030593,GO:0030595,GO:0031982,GO:0032148,GO:0032873,GO:0032991,GO:0034389,GO:0034599,GO:0034774,GO:0035307,GO:0035722,GO:0042118,GO:0043231,GO:0043312,GO:0045069,GO:0045070,GO:0046790,GO:0050714,GO:0050900,GO:0051082,GO:0051092,GO:0060352,GO:0061944,GO:0070062,GO:0070527,GO:0075713,GO:1902176,GO:1903901,GO:1904399,GO:1904813,GO:2001233" activation of MAPK activity|protein peptidyl-prolyl isomerization|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|RNA binding|peptidyl-prolyl cis-trans isomerase activity|integrin binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|cytosol|focal adhesion|RNA-dependent DNA biosynthetic process|protein folding|negative regulation of protein kinase activity|apoptotic process|cyclosporin A binding|membrane|viral life cycle|uncoating of virus|fusion of virus membrane with host plasma membrane|virion assembly|viral release from host cell|platelet activation|neutrophil chemotaxis|leukocyte chemotaxis|vesicle|activation of protein kinase B activity|negative regulation of stress-activated MAPK cascade|protein-containing complex|lipid droplet organization|cellular response to oxidative stress|secretory granule lumen|positive regulation of protein dephosphorylation|interleukin-12-mediated signaling pathway|endothelial cell activation|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of viral genome replication|positive regulation of viral genome replication|virion binding|positive regulation of protein secretion|leukocyte migration|unfolded protein binding|positive regulation of NF-kappaB transcription factor activity|cell adhesion molecule production|negative regulation of protein K48-linked ubiquitination|extracellular exosome|platelet aggregation|establishment of integrated proviral latency|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of viral life cycle|heparan sulfate binding|ficolin-1-rich granule lumen|regulation of apoptotic signaling pathway hsa04217 Necroptosis PPIB 7617.046821 8114.572967 7119.520674 0.877374657 -0.18873506 0.566770954 1 460.2177988 421.1767861 5479 peptidylprolyl isomerase B "GO:0000413,GO:0003723,GO:0003755,GO:0005515,GO:0005518,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005788,GO:0005925,GO:0006457,GO:0016018,GO:0016020,GO:0030593,GO:0032991,GO:0040018,GO:0042470,GO:0043231,GO:0044794,GO:0044829,GO:0048471,GO:0050821,GO:0051082,GO:0060348,GO:0061077,GO:0070062,GO:0070063,GO:1901873" protein peptidyl-prolyl isomerization|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|collagen binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|focal adhesion|protein folding|cyclosporin A binding|membrane|neutrophil chemotaxis|protein-containing complex|positive regulation of multicellular organism growth|melanosome|intracellular membrane-bounded organelle|positive regulation by host of viral process|positive regulation by host of viral genome replication|perinuclear region of cytoplasm|protein stabilization|unfolded protein binding|bone development|chaperone-mediated protein folding|extracellular exosome|RNA polymerase binding|regulation of post-translational protein modification PPIC 729.1127435 708.4392659 749.786221 1.058363443 0.081835136 0.8300654 1 26.30494838 29.03943848 5480 peptidylprolyl isomerase C "GO:0000413,GO:0003755,GO:0005515,GO:0005737,GO:0006457,GO:0016018,GO:0043231,GO:0070062" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|cytoplasm|protein folding|cyclosporin A binding|intracellular membrane-bounded organelle|extracellular exosome PPID 615.5604006 624.1979205 606.9228806 0.972324419 -0.040490341 0.921249473 1 17.27509434 17.52054254 5481 peptidylprolyl isomerase D "GO:0000122,GO:0000413,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006457,GO:0006915,GO:0008134,GO:0015031,GO:0016018,GO:0019076,GO:0030331,GO:0030544,GO:0031072,GO:0034389,GO:0043065,GO:0045070,GO:0050714,GO:0051879,GO:0061077,GO:0065003,GO:0071492" negative regulation of transcription by RNA polymerase II|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|protein folding|apoptotic process|transcription factor binding|protein transport|cyclosporin A binding|viral release from host cell|estrogen receptor binding|Hsp70 protein binding|heat shock protein binding|lipid droplet organization|positive regulation of apoptotic process|positive regulation of viral genome replication|positive regulation of protein secretion|Hsp90 protein binding|chaperone-mediated protein folding|protein-containing complex assembly|cellular response to UV-A "hsa04217,hsa04218,hsa05010,hsa05022,hsa05131" Necroptosis|Cellular senescence|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Shigellosis PPIE 739.8021943 698.2897062 781.3146823 1.118897608 0.16207802 0.666077255 1 19.8239407 23.13642563 10450 peptidylprolyl isomerase E "GO:0000398,GO:0000413,GO:0003723,GO:0003729,GO:0003755,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006283,GO:0006355,GO:0006457,GO:0008143,GO:0016018,GO:0016607,GO:0034774,GO:0043312,GO:0045070,GO:0071007,GO:0071013,GO:1904813" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|RNA binding|mRNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|transcription-coupled nucleotide-excision repair|regulation of transcription, DNA-templated|protein folding|poly(A) binding|cyclosporin A binding|nuclear speck|secretory granule lumen|neutrophil degranulation|positive regulation of viral genome replication|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|ficolin-1-rich granule lumen" hsa03040 Spliceosome PPIF 3874.656007 4419.118286 3330.193728 0.753587823 -0.408152442 0.200392267 1 99.11990766 77.91313699 10105 peptidylprolyl isomerase F "GO:0000413,GO:0002931,GO:0003755,GO:0005515,GO:0005737,GO:0005739,GO:0005753,GO:0005757,GO:0005759,GO:0006457,GO:0008637,GO:0010849,GO:0010939,GO:0016018,GO:0016020,GO:0032780,GO:0043066,GO:0043231,GO:0046902,GO:0070266,GO:0070301,GO:0071243,GO:0071277,GO:0090200,GO:0090201,GO:0090324,GO:1902445,GO:1902686,GO:2000276,GO:2001243" "protein peptidyl-prolyl isomerization|response to ischemia|peptidyl-prolyl cis-trans isomerase activity|protein binding|cytoplasm|mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial permeability transition pore complex|mitochondrial matrix|protein folding|apoptotic mitochondrial changes|regulation of proton-transporting ATPase activity, rotational mechanism|regulation of necrotic cell death|cyclosporin A binding|membrane|negative regulation of ATPase activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|regulation of mitochondrial membrane permeability|necroptotic process|cellular response to hydrogen peroxide|cellular response to arsenic-containing substance|cellular response to calcium ion|positive regulation of release of cytochrome c from mitochondria|negative regulation of release of cytochrome c from mitochondria|negative regulation of oxidative phosphorylation|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death|mitochondrial outer membrane permeabilization involved in programmed cell death|negative regulation of oxidative phosphorylation uncoupler activity|negative regulation of intrinsic apoptotic signaling pathway" "hsa04020,hsa04022,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05145" Calcium signaling pathway|cGMP-PKG signaling pathway|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Toxoplasmosis PPIG 720.5153093 693.2149264 747.8156922 1.078764556 0.109380026 0.773456315 1 5.229985179 5.884953784 9360 peptidylprolyl isomerase G "GO:0000413,GO:0003723,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006457,GO:0008380,GO:0016018,GO:0016363,GO:0016607,GO:0043231" protein peptidyl-prolyl isomerization|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein folding|RNA splicing|cyclosporin A binding|nuclear matrix|nuclear speck|intracellular membrane-bounded organelle PPIH 762.7601914 718.5888256 806.9315572 1.122939195 0.16727981 0.653808237 1 8.525178962 9.98563471 10465 peptidylprolyl isomerase H "GO:0000398,GO:0000413,GO:0003755,GO:0005515,GO:0005654,GO:0005681,GO:0005737,GO:0006457,GO:0016018,GO:0016607,GO:0043021,GO:0043231,GO:0045070,GO:0046540,GO:0065003,GO:0071001" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleoplasm|spliceosomal complex|cytoplasm|protein folding|cyclosporin A binding|nuclear speck|ribonucleoprotein complex binding|intracellular membrane-bounded organelle|positive regulation of viral genome replication|U4/U6 x U5 tri-snRNP complex|protein-containing complex assembly|U4/U6 snRNP" hsa03040 Spliceosome PPIL1 610.8716109 640.437216 581.3060058 0.907670559 -0.139759332 0.722298496 1 21.39570295 20.25679524 51645 peptidylprolyl isomerase like 1 "GO:0000398,GO:0000413,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0006457,GO:0016018,GO:0071007,GO:0071013,GO:0097718" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|protein folding|cyclosporin A binding|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|disordered domain specific binding" hsa03040 Spliceosome PPIL2 1278.162353 1399.62428 1156.700425 0.826436381 -0.27502433 0.417245984 1 10.49230791 9.04474618 23759 peptidylprolyl isomerase like 2 "GO:0000209,GO:0000413,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005796,GO:0005886,GO:0006457,GO:0016018,GO:0034450,GO:0050900,GO:0061630,GO:0072659" protein polyubiquitination|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi lumen|plasma membrane|protein folding|cyclosporin A binding|ubiquitin-ubiquitin ligase activity|leukocyte migration|ubiquitin protein ligase activity|protein localization to plasma membrane hsa04120 Ubiquitin mediated proteolysis PPIL3 221.0095068 223.290313 218.7287005 0.979570934 -0.029778128 0.963936901 1 6.360442427 6.498889394 53938 peptidylprolyl isomerase like 3 "GO:0000398,GO:0000413,GO:0003755,GO:0005515,GO:0006457,GO:0071013" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|protein folding|catalytic step 2 spliceosome" PPIL4 446.188201 394.8178717 497.5585304 1.260222918 0.333678951 0.428810925 1 8.079245401 10.62023441 85313 peptidylprolyl isomerase like 4 "GO:0000413,GO:0003723,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:1901407" protein peptidyl-prolyl isomerization|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of phosphorylation of RNA polymerase II C-terminal domain PPIL6 5.059934066 9.134603715 0.985264417 0.107860663 -3.212759283 0.136251646 1 0.064695211 0.007278655 285755 peptidylprolyl isomerase like 6 "GO:0000413,GO:0003755,GO:0005515,GO:0005737,GO:0006457,GO:0016018" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|cytoplasm|protein folding|cyclosporin A binding PPIP5K1 395.3431631 387.7131799 402.9731464 1.039358906 0.055693924 0.903868947 1 3.256975418 3.530985645 9677 diphosphoinositol pentakisphosphate kinase 1 "GO:0000827,GO:0000828,GO:0000829,GO:0000832,GO:0005524,GO:0005829,GO:0005886,GO:0006020,GO:0016310,GO:0032958,GO:0033857,GO:0043647,GO:0052723,GO:0052724,GO:0102092" "inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|ATP binding|cytosol|plasma membrane|inositol metabolic process|phosphorylation|inositol phosphate biosynthetic process|diphosphoinositol-pentakisphosphate kinase activity|inositol phosphate metabolic process|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|5-diphosphoinositol pentakisphosphate 3-kinase activity" hsa04070 Phosphatidylinositol signaling system PPIP5K2 1017.948872 1022.06066 1013.837085 0.991953926 -0.011654982 0.976633207 1 3.183503495 3.293917832 23262 diphosphoinositol pentakisphosphate kinase 2 "GO:0000827,GO:0000828,GO:0000829,GO:0000832,GO:0005524,GO:0005829,GO:0006020,GO:0007605,GO:0016310,GO:0032958,GO:0033857,GO:0043647,GO:0052723,GO:0052724,GO:0102092" "inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|ATP binding|cytosol|inositol metabolic process|sensory perception of sound|phosphorylation|inositol phosphate biosynthetic process|diphosphoinositol-pentakisphosphate kinase activity|inositol phosphate metabolic process|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|5-diphosphoinositol pentakisphosphate 3-kinase activity" hsa04070 Phosphatidylinositol signaling system PPL 56.78087273 76.12169763 37.44004783 0.491844625 -1.023725458 0.210729621 1 0.604467771 0.310110884 5493 periplakin "GO:0001533,GO:0005198,GO:0005200,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005882,GO:0005886,GO:0009612,GO:0016020,GO:0030057,GO:0042060,GO:0045104,GO:0045296,GO:0070062,GO:0070268" cornified envelope|structural molecule activity|structural constituent of cytoskeleton|protein binding|cytoplasm|cytosol|cytoskeleton|intermediate filament|plasma membrane|response to mechanical stimulus|membrane|desmosome|wound healing|intermediate filament cytoskeleton organization|cadherin binding|extracellular exosome|cornification PPM1A 1018.010977 992.6269371 1043.395017 1.051145177 0.071961938 0.840063726 1 5.152511283 5.649338307 5494 "protein phosphatase, Mg2+/Mn2+ dependent 1A" "GO:0000122,GO:0000287,GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006470,GO:0006499,GO:0007050,GO:0010991,GO:0016020,GO:0016311,GO:0030145,GO:0030512,GO:0030514,GO:0033192,GO:0035970,GO:0043123,GO:0043124,GO:0045893,GO:0046827,GO:0070412,GO:0071560,GO:0090263,GO:0106306,GO:0106307,GO:1901223" "negative regulation of transcription by RNA polymerase II|magnesium ion binding|protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein dephosphorylation|N-terminal protein myristoylation|cell cycle arrest|negative regulation of SMAD protein complex assembly|membrane|dephosphorylation|manganese ion binding|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|calmodulin-dependent protein phosphatase activity|peptidyl-threonine dephosphorylation|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|positive regulation of protein export from nucleus|R-SMAD binding|cellular response to transforming growth factor beta stimulus|positive regulation of canonical Wnt signaling pathway|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of NIK/NF-kappaB signaling" hsa04010 MAPK signaling pathway PPM1B 538.2874134 494.2835566 582.2912702 1.178051065 0.236402077 0.55737448 1 3.172037305 3.897789059 5495 "protein phosphatase, Mg2+/Mn2+ dependent 1B" "GO:0000287,GO:0004722,GO:0005515,GO:0005634,GO:0005730,GO:0005829,GO:0006470,GO:0006499,GO:0016020,GO:0030145,GO:0032688,GO:0035970,GO:0043124,GO:0050687,GO:0090263,GO:0106306,GO:0106307,GO:1901223" magnesium ion binding|protein serine/threonine phosphatase activity|protein binding|nucleus|nucleolus|cytosol|protein dephosphorylation|N-terminal protein myristoylation|membrane|manganese ion binding|negative regulation of interferon-beta production|peptidyl-threonine dephosphorylation|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of defense response to virus|positive regulation of canonical Wnt signaling pathway|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of NIK/NF-kappaB signaling hsa04010 MAPK signaling pathway PPM1D 308.4253727 272.0081995 344.8425458 1.26776526 0.34228764 0.466980163 1 2.889315377 3.82075971 8493 "protein phosphatase, Mg2+/Mn2+ dependent 1D" "GO:0000086,GO:0004674,GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006306,GO:0006342,GO:0006367,GO:0006468,GO:0006470,GO:0008285,GO:0009267,GO:0009314,GO:0009617,GO:0030330,GO:0035970,GO:0045814,GO:0046872,GO:0051019,GO:0106306,GO:0106307" "G2/M transition of mitotic cell cycle|protein serine/threonine kinase activity|protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA methylation|chromatin silencing|transcription initiation from RNA polymerase II promoter|protein phosphorylation|protein dephosphorylation|negative regulation of cell population proliferation|cellular response to starvation|response to radiation|response to bacterium|DNA damage response, signal transduction by p53 class mediator|peptidyl-threonine dephosphorylation|negative regulation of gene expression, epigenetic|metal ion binding|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity" hsa04115 p53 signaling pathway PPM1E 4.926322083 0 9.852644165 Inf Inf 0.042064871 0.939853769 0 0.057704727 22843 "protein phosphatase, Mg2+/Mn2+ dependent 1E" "GO:0004722,GO:0004724,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0006469,GO:0006470,GO:0032991,GO:0035690,GO:0035970,GO:0046872,GO:0051496,GO:0106306,GO:0106307" protein serine/threonine phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|mitochondrion|negative regulation of protein kinase activity|protein dephosphorylation|protein-containing complex|cellular response to drug|peptidyl-threonine dephosphorylation|metal ion binding|positive regulation of stress fiber assembly|protein serine phosphatase activity|protein threonine phosphatase activity PPM1F 1573.06001 1521.418997 1624.701023 1.067885327 0.094756734 0.775110384 1 12.82104907 14.28118061 9647 "protein phosphatase, Mg2+/Mn2+ dependent 1F" "GO:0004722,GO:0004724,GO:0005515,GO:0005634,GO:0005829,GO:0006469,GO:0006470,GO:0008138,GO:0010628,GO:0010634,GO:0010811,GO:0016576,GO:0030335,GO:0032991,GO:0033137,GO:0033192,GO:0035690,GO:0035970,GO:0043280,GO:0044387,GO:0045892,GO:0045927,GO:0046872,GO:0048471,GO:0050921,GO:0051224,GO:0051496,GO:0051894,GO:0070262,GO:0097193,GO:0106306,GO:0106307,GO:1903827,GO:2000048" "protein serine/threonine phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|cytosol|negative regulation of protein kinase activity|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|positive regulation of gene expression|positive regulation of epithelial cell migration|positive regulation of cell-substrate adhesion|histone dephosphorylation|positive regulation of cell migration|protein-containing complex|negative regulation of peptidyl-serine phosphorylation|calmodulin-dependent protein phosphatase activity|cellular response to drug|peptidyl-threonine dephosphorylation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|negative regulation of transcription, DNA-templated|positive regulation of growth|metal ion binding|perinuclear region of cytoplasm|positive regulation of chemotaxis|negative regulation of protein transport|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|peptidyl-serine dephosphorylation|intrinsic apoptotic signaling pathway|protein serine phosphatase activity|protein threonine phosphatase activity|regulation of cellular protein localization|negative regulation of cell-cell adhesion mediated by cadherin" PPM1G 2430.726257 3070.241804 1791.210709 0.583410306 -0.777417224 0.015333808 0.546932731 70.36059558 42.81732517 5496 "protein phosphatase, Mg2+/Mn2+ dependent 1G" "GO:0004722,GO:0004724,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006470,GO:0007050,GO:0016020,GO:0035970,GO:0046872,GO:0106306,GO:0106307" protein serine/threonine phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein dephosphorylation|cell cycle arrest|membrane|peptidyl-threonine dephosphorylation|metal ion binding|protein serine phosphatase activity|protein threonine phosphatase activity PPM1H 16.09083773 22.3290313 9.852644165 0.441248168 -1.180337805 0.329776901 1 0.14345892 0.066027735 57460 "protein phosphatase, Mg2+/Mn2+ dependent 1H" "GO:0004721,GO:0004724,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006470,GO:0042802,GO:0098978,GO:0106306,GO:0106307" phosphoprotein phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein dephosphorylation|identical protein binding|glutamatergic synapse|protein serine phosphatase activity|protein threonine phosphatase activity PPM1J 131.7594456 150.2134833 113.3054079 0.754295855 -0.406797596 0.514433367 1 4.438613191 3.492246982 333926 "protein phosphatase, Mg2+/Mn2+ dependent 1J" "GO:0004724,GO:0005515,GO:0006470,GO:0106306,GO:0106307" magnesium-dependent protein serine/threonine phosphatase activity|protein binding|protein dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity PPM1K 257.5533648 229.3800489 285.7266808 1.245647484 0.316895846 0.525862838 1 1.300928362 1.690302629 152926 "protein phosphatase, Mg2+/Mn2+ dependent 1K" "GO:0005515,GO:0005739,GO:0005759,GO:0006470,GO:0009083,GO:0046872,GO:0106306,GO:0106307" protein binding|mitochondrion|mitochondrial matrix|protein dephosphorylation|branched-chain amino acid catabolic process|metal ion binding|protein serine phosphatase activity|protein threonine phosphatase activity PPM1L 146.2657447 198.9313698 93.60011957 0.470514629 -1.087688517 0.070031531 1 0.719963705 0.35334558 151742 "protein phosphatase, Mg2+/Mn2+ dependent 1L" "GO:0000165,GO:0004722,GO:0004724,GO:0005789,GO:0006470,GO:0007178,GO:0016021,GO:0030148,GO:0046872,GO:0070062,GO:0106306,GO:0106307" MAPK cascade|protein serine/threonine phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|endoplasmic reticulum membrane|protein dephosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|integral component of membrane|sphingolipid biosynthetic process|metal ion binding|extracellular exosome|protein serine phosphatase activity|protein threonine phosphatase activity PPM1M 286.7077398 235.4697847 337.9456949 1.435197706 0.52124949 0.277738331 1 4.891597172 7.322819791 132160 "protein phosphatase, Mg2+/Mn2+ dependent 1M" "GO:0004724,GO:0005634,GO:0006470,GO:0030145,GO:0106306,GO:0106307" magnesium-dependent protein serine/threonine phosphatase activity|nucleus|protein dephosphorylation|manganese ion binding|protein serine phosphatase activity|protein threonine phosphatase activity PPM1N 39.67507903 51.76275439 27.58740366 0.532958572 -0.907904701 0.321363246 1 1.497202114 0.832319008 147699 "protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)" "GO:0000287,GO:0005634,GO:0005829,GO:0006470,GO:0030145,GO:0043124,GO:0090263,GO:0106306,GO:0106307" magnesium ion binding|nucleus|cytosol|protein dephosphorylation|manganese ion binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of canonical Wnt signaling pathway|protein serine phosphatase activity|protein threonine phosphatase activity PPME1 1647.304213 1814.741271 1479.867154 0.815470049 -0.294296205 0.369644692 1 33.45840676 28.45962682 51400 protein phosphatase methylesterase 1 "GO:0000086,GO:0004864,GO:0005515,GO:0005654,GO:0006482,GO:0018215,GO:0019888,GO:0019901,GO:0019903,GO:0032515,GO:0045296,GO:0051721,GO:0051722,GO:0051723" G2/M transition of mitotic cell cycle|protein phosphatase inhibitor activity|protein binding|nucleoplasm|protein demethylation|protein phosphopantetheinylation|protein phosphatase regulator activity|protein kinase binding|protein phosphatase binding|negative regulation of phosphoprotein phosphatase activity|cadherin binding|protein phosphatase 2A binding|protein C-terminal methylesterase activity|protein methylesterase activity PPOX 411.4394441 343.0551173 479.8237709 1.398678366 0.484064245 0.260870279 1 4.87774606 7.11627912 5498 protoporphyrinogen oxidase "GO:0004729,GO:0005758,GO:0006779,GO:0006782,GO:0006783,GO:0016491,GO:0031304,GO:0031305,GO:0031966,GO:0042493,GO:0050660,GO:0055114" oxygen-dependent protoporphyrinogen oxidase activity|mitochondrial intermembrane space|porphyrin-containing compound biosynthetic process|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|oxidoreductase activity|intrinsic component of mitochondrial inner membrane|integral component of mitochondrial inner membrane|mitochondrial membrane|response to drug|flavin adenine dinucleotide binding|oxidation-reduction process hsa00860 Porphyrin and chlorophyll metabolism PPP1CA 4516.601796 4220.186916 4813.016675 1.140474763 0.189634523 0.553332068 1 146.9997107 174.8711191 5499 protein phosphatase 1 catalytic subunit alpha "GO:0000164,GO:0000781,GO:0004721,GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005977,GO:0005979,GO:0005981,GO:0006470,GO:0007049,GO:0008157,GO:0010288,GO:0016032,GO:0016311,GO:0016791,GO:0030324,GO:0032091,GO:0032922,GO:0035970,GO:0036496,GO:0042587,GO:0042752,GO:0043021,GO:0043153,GO:0043197,GO:0043204,GO:0046872,GO:0048754,GO:0051301,GO:0060828,GO:0070062,GO:0070262,GO:0072357,GO:0098609,GO:0098641,GO:0098793,GO:0098978,GO:0106306,GO:0106307,GO:1904886,GO:2001241" "protein phosphatase type 1 complex|chromosome, telomeric region|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|adherens junction|glycogen metabolic process|regulation of glycogen biosynthetic process|regulation of glycogen catabolic process|protein dephosphorylation|cell cycle|protein phosphatase 1 binding|response to lead ion|viral process|dephosphorylation|phosphatase activity|lung development|negative regulation of protein binding|circadian regulation of gene expression|peptidyl-threonine dephosphorylation|regulation of translational initiation by eIF2 alpha dephosphorylation|glycogen granule|regulation of circadian rhythm|ribonucleoprotein complex binding|entrainment of circadian clock by photoperiod|dendritic spine|perikaryon|metal ion binding|branching morphogenesis of an epithelial tube|cell division|regulation of canonical Wnt signaling pathway|extracellular exosome|peptidyl-serine dephosphorylation|PTW/PP1 phosphatase complex|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|presynapse|glutamatergic synapse|protein serine phosphatase activity|protein threonine phosphatase activity|beta-catenin destruction complex disassembly|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa03015,hsa04022,hsa04024,hsa04114,hsa04218,hsa04261,hsa04270,hsa04390,hsa04510,hsa04611,hsa04720,hsa04728,hsa04750,hsa04810,hsa04910,hsa04921,hsa04931,hsa05031,hsa05034,hsa05168,hsa05205" mRNA surveillance pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Hippo signaling pathway|Focal adhesion|Platelet activation|Long-term potentiation|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Oxytocin signaling pathway|Insulin resistance|Amphetamine addiction|Alcoholism|Herpes simplex virus 1 infection|Proteoglycans in cancer PPP1CB 2691.322014 2968.746207 2413.897821 0.813103462 -0.298489157 0.348906477 1 29.2921337 24.84349817 5500 protein phosphatase 1 catalytic subunit beta "GO:0000086,GO:0000164,GO:0000781,GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0005977,GO:0005979,GO:0005981,GO:0006470,GO:0016791,GO:0017018,GO:0019901,GO:0030155,GO:0032922,GO:0042587,GO:0042752,GO:0043153,GO:0046872,GO:0050115,GO:0051301,GO:0070062,GO:0072357,GO:0106306,GO:0106307" "G2/M transition of mitotic cell cycle|protein phosphatase type 1 complex|chromosome, telomeric region|protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|focal adhesion|glycogen metabolic process|regulation of glycogen biosynthetic process|regulation of glycogen catabolic process|protein dephosphorylation|phosphatase activity|myosin phosphatase activity|protein kinase binding|regulation of cell adhesion|circadian regulation of gene expression|glycogen granule|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|metal ion binding|myosin-light-chain-phosphatase activity|cell division|extracellular exosome|PTW/PP1 phosphatase complex|protein serine phosphatase activity|protein threonine phosphatase activity" "hsa03015,hsa04022,hsa04024,hsa04114,hsa04218,hsa04261,hsa04270,hsa04390,hsa04510,hsa04611,hsa04720,hsa04728,hsa04750,hsa04810,hsa04910,hsa04921,hsa04931,hsa05031,hsa05034,hsa05168,hsa05205" mRNA surveillance pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Hippo signaling pathway|Focal adhesion|Platelet activation|Long-term potentiation|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Oxytocin signaling pathway|Insulin resistance|Amphetamine addiction|Alcoholism|Herpes simplex virus 1 infection|Proteoglycans in cancer PPP1CC 4245.289864 3925.849686 4564.730042 1.162736836 0.217524606 0.495675287 1 59.10536178 71.68433173 5501 protein phosphatase 1 catalytic subunit gamma "GO:0000164,GO:0000777,GO:0000781,GO:0003723,GO:0004721,GO:0004722,GO:0005515,GO:0005521,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0005925,GO:0005977,GO:0006470,GO:0007049,GO:0008022,GO:0008157,GO:0016607,GO:0016791,GO:0019901,GO:0019904,GO:0030182,GO:0030496,GO:0032154,GO:0032922,GO:0032991,GO:0042752,GO:0043153,GO:0043197,GO:0044877,GO:0046822,GO:0046872,GO:0047485,GO:0051301,GO:0060252,GO:0072357,GO:0098793,GO:0098978,GO:0106306,GO:0106307" "protein phosphatase type 1 complex|condensed chromosome kinetochore|chromosome, telomeric region|RNA binding|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|lamin binding|nucleus|nucleolus|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|focal adhesion|glycogen metabolic process|protein dephosphorylation|cell cycle|protein C-terminus binding|protein phosphatase 1 binding|nuclear speck|phosphatase activity|protein kinase binding|protein domain specific binding|neuron differentiation|midbody|cleavage furrow|circadian regulation of gene expression|protein-containing complex|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|dendritic spine|protein-containing complex binding|regulation of nucleocytoplasmic transport|metal ion binding|protein N-terminus binding|cell division|positive regulation of glial cell proliferation|PTW/PP1 phosphatase complex|presynapse|glutamatergic synapse|protein serine phosphatase activity|protein threonine phosphatase activity" "hsa03015,hsa04022,hsa04024,hsa04114,hsa04218,hsa04261,hsa04270,hsa04390,hsa04510,hsa04611,hsa04720,hsa04728,hsa04750,hsa04810,hsa04910,hsa04921,hsa04931,hsa05031,hsa05034,hsa05168,hsa05205" mRNA surveillance pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Hippo signaling pathway|Focal adhesion|Platelet activation|Long-term potentiation|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Oxytocin signaling pathway|Insulin resistance|Amphetamine addiction|Alcoholism|Herpes simplex virus 1 infection|Proteoglycans in cancer PPP1R10 1844.365015 2084.719559 1604.01047 0.769413067 -0.378169763 0.243733969 1 22.18144773 17.80185977 5514 protein phosphatase 1 regulatory subunit 10 "GO:0000781,GO:0000785,GO:0003677,GO:0003723,GO:0004864,GO:0005515,GO:0005634,GO:0005654,GO:0006606,GO:0010667,GO:0016604,GO:0032206,GO:0032515,GO:0046872,GO:0072357,GO:1904290" "chromosome, telomeric region|chromatin|DNA binding|RNA binding|protein phosphatase inhibitor activity|protein binding|nucleus|nucleoplasm|protein import into nucleus|negative regulation of cardiac muscle cell apoptotic process|nuclear body|positive regulation of telomere maintenance|negative regulation of phosphoprotein phosphatase activity|metal ion binding|PTW/PP1 phosphatase complex|negative regulation of mitotic DNA damage checkpoint" PPP1R11 783.26443 806.8899949 759.6388652 0.941440432 -0.087058282 0.816248012 1 21.90039212 21.50605076 6992 protein phosphatase 1 regulatory inhibitor subunit 11 "GO:0001818,GO:0004865,GO:0005515,GO:0005634,GO:0005737,GO:0006511,GO:0008157,GO:0016567,GO:0032515,GO:0050830,GO:0061630" negative regulation of cytokine production|protein serine/threonine phosphatase inhibitor activity|protein binding|nucleus|cytoplasm|ubiquitin-dependent protein catabolic process|protein phosphatase 1 binding|protein ubiquitination|negative regulation of phosphoprotein phosphatase activity|defense response to Gram-positive bacterium|ubiquitin protein ligase activity PPP1R12A 2286.562423 2173.020728 2400.104119 1.104501254 0.143395056 0.65455698 1 18.81939705 21.68142626 4659 protein phosphatase 1 regulatory subunit 12A "GO:0000086,GO:0000278,GO:0000776,GO:0004857,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005925,GO:0006470,GO:0007098,GO:0007165,GO:0015629,GO:0019208,GO:0019901,GO:0030018,GO:0030155,GO:0031672,GO:0035507,GO:0035508,GO:0035690,GO:0043086,GO:0043292,GO:0045944,GO:0046822,GO:0071889,GO:0072357,GO:1903140" G2/M transition of mitotic cell cycle|mitotic cell cycle|kinetochore|enzyme inhibitor activity|protein binding|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|plasma membrane|focal adhesion|protein dephosphorylation|centrosome cycle|signal transduction|actin cytoskeleton|phosphatase regulator activity|protein kinase binding|Z disc|regulation of cell adhesion|A band|regulation of myosin-light-chain-phosphatase activity|positive regulation of myosin-light-chain-phosphatase activity|cellular response to drug|negative regulation of catalytic activity|contractile fiber|positive regulation of transcription by RNA polymerase II|regulation of nucleocytoplasmic transport|14-3-3 protein binding|PTW/PP1 phosphatase complex|regulation of establishment of endothelial barrier "hsa04022,hsa04024,hsa04270,hsa04510,hsa04611,hsa04810,hsa04921,hsa05205" cGMP-PKG signaling pathway|cAMP signaling pathway|Vascular smooth muscle contraction|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Proteoglycans in cancer PPP1R12B 571.7391446 524.7322356 618.7460536 1.179165318 0.237765997 0.549167712 1 1.744737171 2.145955148 4660 protein phosphatase 1 regulatory subunit 12B "GO:0000086,GO:0004857,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006937,GO:0007165,GO:0008047,GO:0019208,GO:0019901,GO:0030018,GO:0031672,GO:0043086" G2/M transition of mitotic cell cycle|enzyme inhibitor activity|protein binding|nucleoplasm|cytoplasm|cytosol|cytoskeleton|regulation of muscle contraction|signal transduction|enzyme activator activity|phosphatase regulator activity|protein kinase binding|Z disc|A band|negative regulation of catalytic activity "hsa04270,hsa04510,hsa04810,hsa04921,hsa05205" Vascular smooth muscle contraction|Focal adhesion|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Proteoglycans in cancer PPP1R12C 1243.672901 1096.152446 1391.193356 1.269160473 0.343874495 0.312267842 1 18.4930894 24.48172057 54776 protein phosphatase 1 regulatory subunit 12C "GO:0004857,GO:0005515,GO:0005737,GO:0005856,GO:0007165,GO:0019208,GO:0019901,GO:0043086" enzyme inhibitor activity|protein binding|cytoplasm|cytoskeleton|signal transduction|phosphatase regulator activity|protein kinase binding|negative regulation of catalytic activity "hsa04270,hsa04510,hsa04810,hsa04921,hsa05205" Vascular smooth muscle contraction|Focal adhesion|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Proteoglycans in cancer PPP1R13B 396.4944527 365.3841486 427.6047568 1.170288198 0.226863855 0.604373554 1 2.658442484 3.245159323 23368 protein phosphatase 1 regulatory subunit 13B "GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0008134,GO:0042981,GO:0045786,GO:0048471,GO:0072332,GO:1900740,GO:1901216,GO:1901796" p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|transcription factor binding|regulation of apoptotic process|negative regulation of cell cycle|perinuclear region of cytoplasm|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of neuron death|regulation of signal transduction by p53 class mediator PPP1R13L 1139.059445 1050.479427 1227.639463 1.16864684 0.224839019 0.515075001 1 15.75920531 19.2102728 10848 protein phosphatase 1 regulatory subunit 13 like "GO:0000122,GO:0003215,GO:0003229,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0006915,GO:0008134,GO:0009791,GO:0030054,GO:0031076,GO:0035264,GO:0042633,GO:0042802,GO:0045171,GO:0045296,GO:0045597,GO:0048871,GO:0060048,GO:1901796" "negative regulation of transcription by RNA polymerase II|cardiac right ventricle morphogenesis|ventricular cardiac muscle tissue development|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription by RNA polymerase II|apoptotic process|transcription factor binding|post-embryonic development|cell junction|embryonic camera-type eye development|multicellular organism growth|hair cycle|identical protein binding|intercellular bridge|cadherin binding|positive regulation of cell differentiation|multicellular organismal homeostasis|cardiac muscle contraction|regulation of signal transduction by p53 class mediator" PPP1R14B 2193.497744 2748.500762 1638.494725 0.596141266 -0.746273852 0.020351306 0.616714654 140.7501188 87.52132532 26472 protein phosphatase 1 regulatory inhibitor subunit 14B "GO:0004865,GO:0005737,GO:0032515,GO:0042325,GO:0045087" protein serine/threonine phosphatase inhibitor activity|cytoplasm|negative regulation of phosphoprotein phosphatase activity|regulation of phosphorylation|innate immune response PPP1R14C 7.508249331 8.119647747 6.896850916 0.849402724 -0.235479359 0.974243744 1 0.10477236 0.092827426 81706 protein phosphatase 1 regulatory inhibitor subunit 14C "GO:0004865,GO:0005737,GO:0016020,GO:0032515,GO:0042325" protein serine/threonine phosphatase inhibitor activity|cytoplasm|membrane|negative regulation of phosphoprotein phosphatase activity|regulation of phosphorylation PPP1R15A 1410.837039 1309.293199 1512.380879 1.155112453 0.208033309 0.534157957 1 28.21748154 33.99839736 23645 protein phosphatase 1 regulatory subunit 15A "GO:0000164,GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006915,GO:0006974,GO:0007050,GO:0008157,GO:0016020,GO:0019888,GO:0019901,GO:0032058,GO:0032515,GO:0032516,GO:0034976,GO:0035308,GO:0036496,GO:0070059,GO:0070972,GO:0072542,GO:1902310,GO:1903898,GO:1903917" protein phosphatase type 1 complex|protein binding|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|apoptotic process|cellular response to DNA damage stimulus|cell cycle arrest|protein phosphatase 1 binding|membrane|protein phosphatase regulator activity|protein kinase binding|positive regulation of translational initiation in response to stress|negative regulation of phosphoprotein phosphatase activity|positive regulation of phosphoprotein phosphatase activity|response to endoplasmic reticulum stress|negative regulation of protein dephosphorylation|regulation of translational initiation by eIF2 alpha dephosphorylation|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|protein localization to endoplasmic reticulum|protein phosphatase activator activity|positive regulation of peptidyl-serine dephosphorylation|negative regulation of PERK-mediated unfolded protein response|positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation hsa04141 Protein processing in endoplasmic reticulum PPP1R15B 1404.880915 1306.248331 1503.5135 1.15101659 0.202908627 0.54454985 1 10.56312786 12.68206719 84919 protein phosphatase 1 regulatory subunit 15B "GO:0000164,GO:0001933,GO:0005515,GO:0005783,GO:0006983,GO:0019888,GO:0032516,GO:0034976,GO:0042542,GO:0070262,GO:1903898,GO:1903912" protein phosphatase type 1 complex|negative regulation of protein phosphorylation|protein binding|endoplasmic reticulum|ER overload response|protein phosphatase regulator activity|positive regulation of phosphoprotein phosphatase activity|response to endoplasmic reticulum stress|response to hydrogen peroxide|peptidyl-serine dephosphorylation|negative regulation of PERK-mediated unfolded protein response|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation PPP1R16A 1340.298837 1336.69701 1343.900664 1.005389145 0.007754018 0.984103923 1 20.09468329 21.07323873 84988 protein phosphatase 1 regulatory subunit 16A "GO:0005515,GO:0005886,GO:0008157,GO:0017020,GO:0019888,GO:0035304,GO:0043666" protein binding|plasma membrane|protein phosphatase 1 binding|myosin phosphatase regulator activity|protein phosphatase regulator activity|regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity PPP1R18 2407.31546 2008.597861 2806.033058 1.397010876 0.482343253 0.13134053 1 29.54644083 43.05473199 170954 protein phosphatase 1 regulatory subunit 18 "GO:0003779,GO:0005515,GO:0005737,GO:0005856,GO:0019902" actin binding|protein binding|cytoplasm|cytoskeleton|phosphatase binding PPP1R1C 15.50913087 16.23929549 14.77896625 0.910074347 -0.135943686 0.968727396 1 0.218449675 0.207369178 151242 protein phosphatase 1 regulatory inhibitor subunit 1C "GO:0004864,GO:0005515,GO:0005737,GO:0007049,GO:0032515,GO:0035556,GO:0051301" protein phosphatase inhibitor activity|protein binding|cytoplasm|cell cycle|negative regulation of phosphoprotein phosphatase activity|intracellular signal transduction|cell division PPP1R2 714.0071701 686.1102346 741.9041057 1.081319106 0.112792337 0.76693008 1 9.76371535 11.01247451 5504 protein phosphatase 1 regulatory inhibitor subunit 2 "GO:0004864,GO:0004865,GO:0005515,GO:0005977,GO:0006091,GO:0009966,GO:0032515,GO:0043666" protein phosphatase inhibitor activity|protein serine/threonine phosphatase inhibitor activity|protein binding|glycogen metabolic process|generation of precursor metabolites and energy|regulation of signal transduction|negative regulation of phosphoprotein phosphatase activity|regulation of phosphoprotein phosphatase activity PPP1R21 340.6191723 351.1747651 330.0635795 0.939884104 -0.089445224 0.849745572 1 5.540736131 5.43197425 129285 protein phosphatase 1 regulatory subunit 21 "GO:0005769,GO:0016020" early endosome|membrane PPP1R26 1739.819353 1572.166795 1907.47191 1.21327579 0.278907527 0.392560861 1 10.1393992 12.831803 9858 protein phosphatase 1 regulatory subunit 26 "GO:0004864,GO:0005515,GO:0005730,GO:0010923,GO:0032515" protein phosphatase inhibitor activity|protein binding|nucleolus|negative regulation of phosphatase activity|negative regulation of phosphoprotein phosphatase activity PPP1R2B 8.030573092 10.14955968 5.911586499 0.582447582 -0.779799875 0.654071524 1 0.230098206 0.139793188 153743 PPP1R2 family member B "GO:0004864,GO:0005515,GO:0005977,GO:0009966,GO:0032515,GO:0043666" protein phosphatase inhibitor activity|protein binding|glycogen metabolic process|regulation of signal transduction|negative regulation of phosphoprotein phosphatase activity|regulation of phosphoprotein phosphatase activity PPP1R32 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.033553485 0.101924929 220004 protein phosphatase 1 regulatory subunit 32 "GO:0005515,GO:0019902,GO:0036064" protein binding|phosphatase binding|ciliary basal body PPP1R35 628.9168939 493.2686006 764.5651872 1.549997681 0.632266057 0.102516739 1 23.99838086 38.79974931 221908 protein phosphatase 1 regulatory subunit 35 "GO:0004864,GO:0010923,GO:0019902,GO:0032515" protein phosphatase inhibitor activity|negative regulation of phosphatase activity|phosphatase binding|negative regulation of phosphoprotein phosphatase activity PPP1R36 5.015396738 6.08973581 3.941057666 0.64716398 -0.627796782 0.826813936 1 0.197961255 0.133631999 145376 protein phosphatase 1 regulatory subunit 36 "GO:0004864,GO:0010923,GO:0019902,GO:0032515" protein phosphatase inhibitor activity|negative regulation of phosphatase activity|phosphatase binding|negative regulation of phosphoprotein phosphatase activity PPP1R37 510.6851639 493.2686006 528.1017273 1.070616955 0.098442406 0.812542922 1 8.462843657 9.450751947 284352 protein phosphatase 1 regulatory subunit 37 "GO:0004864,GO:0005515,GO:0010923,GO:0032515" protein phosphatase inhibitor activity|protein binding|negative regulation of phosphatase activity|negative regulation of phosphoprotein phosphatase activity PPP1R3B 1133.718433 1561.002279 706.4345867 0.452551925 -1.143844761 0.001037635 0.093139798 13.85060592 6.538123489 79660 protein phosphatase 1 regulatory subunit 3B "GO:0000164,GO:0005515,GO:0005977,GO:0005979,GO:0005981,GO:0006470,GO:0008157,GO:0019888,GO:0042587,GO:0043231,GO:0043666,GO:0050196,GO:2001069" protein phosphatase type 1 complex|protein binding|glycogen metabolic process|regulation of glycogen biosynthetic process|regulation of glycogen catabolic process|protein dephosphorylation|protein phosphatase 1 binding|protein phosphatase regulator activity|glycogen granule|intracellular membrane-bounded organelle|regulation of phosphoprotein phosphatase activity|[phosphorylase] phosphatase activity|glycogen binding "hsa04910,hsa04931" Insulin signaling pathway|Insulin resistance PPP1R3C 223.6696222 371.4738844 75.86536007 0.204227977 -2.291747579 2.66E-05 0.005633337 7.404109313 1.577262537 5507 protein phosphatase 1 regulatory subunit 3C "GO:0000164,GO:0004722,GO:0005515,GO:0005829,GO:0005977,GO:0005978,GO:0005979,GO:0006470,GO:0008157,GO:0019903,GO:2001069" protein phosphatase type 1 complex|protein serine/threonine phosphatase activity|protein binding|cytosol|glycogen metabolic process|glycogen biosynthetic process|regulation of glycogen biosynthetic process|protein dephosphorylation|protein phosphatase 1 binding|protein phosphatase binding|glycogen binding "hsa04910,hsa04931" Insulin signaling pathway|Insulin resistance PPP1R3D 232.5209185 201.9762377 263.0655992 1.302458161 0.38123703 0.459588631 1 2.807956056 3.814784576 5509 protein phosphatase 1 regulatory subunit 3D "GO:0000164,GO:0004722,GO:0005515,GO:0005977,GO:0005979,GO:0005981,GO:0006470,GO:0008157,GO:0042587,GO:0043231,GO:2001069" protein phosphatase type 1 complex|protein serine/threonine phosphatase activity|protein binding|glycogen metabolic process|regulation of glycogen biosynthetic process|regulation of glycogen catabolic process|protein dephosphorylation|protein phosphatase 1 binding|glycogen granule|intracellular membrane-bounded organelle|glycogen binding "hsa04910,hsa04931" Insulin signaling pathway|Insulin resistance PPP1R3E 169.8972449 197.9164138 141.878076 0.716858563 -0.480239594 0.399937775 1 2.099218461 1.569665251 90673 protein phosphatase 1 regulatory subunit 3E "GO:0000164,GO:0005977,GO:0005979,GO:0006470,GO:0008157,GO:0042587,GO:0045725,GO:0050196,GO:2001069" protein phosphatase type 1 complex|glycogen metabolic process|regulation of glycogen biosynthetic process|protein dephosphorylation|protein phosphatase 1 binding|glycogen granule|positive regulation of glycogen biosynthetic process|[phosphorylase] phosphatase activity|glycogen binding "hsa04910,hsa04931" Insulin signaling pathway|Insulin resistance PPP1R3F 252.5352465 256.78386 248.286633 0.96690903 -0.048547932 0.930771457 1 1.411920164 1.424005564 89801 protein phosphatase 1 regulatory subunit 3F "GO:0000164,GO:0005979,GO:0008157,GO:0016020,GO:0016021,GO:0019903,GO:2000465,GO:2001069" protein phosphatase type 1 complex|regulation of glycogen biosynthetic process|protein phosphatase 1 binding|membrane|integral component of membrane|protein phosphatase binding|regulation of glycogen (starch) synthase activity|glycogen binding hsa04910 Insulin signaling pathway PPP1R3G 92.03710766 128.899408 55.17480733 0.428045467 -1.224164046 0.080900815 1 1.574222398 0.702865003 648791 protein phosphatase 1 regulatory subunit 3G "GO:0000164,GO:0005979,GO:0008157,GO:0042593,GO:0045725,GO:2000467,GO:2001069" protein phosphatase type 1 complex|regulation of glycogen biosynthetic process|protein phosphatase 1 binding|glucose homeostasis|positive regulation of glycogen biosynthetic process|positive regulation of glycogen (starch) synthase activity|glycogen binding PPP1R7 493.2648873 481.089129 505.4406457 1.050617474 0.071237485 0.866585526 1 9.393009716 10.29355339 5510 protein phosphatase 1 regulatory subunit 7 "GO:0005515,GO:0005634,GO:0005694,GO:0005737,GO:0019888,GO:0030234,GO:0035307,GO:0043666,GO:0070062" protein binding|nucleus|chromosome|cytoplasm|protein phosphatase regulator activity|enzyme regulator activity|positive regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|extracellular exosome PPP1R8 876.7551859 866.772397 886.7379749 1.023034395 0.03285465 0.930700004 1 19.9540746 21.29304424 5511 protein phosphatase 1 regulatory subunit 8 "GO:0003677,GO:0003723,GO:0003729,GO:0004519,GO:0004865,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006397,GO:0006401,GO:0008283,GO:0008380,GO:0008995,GO:0016607,GO:0032515,GO:0035308,GO:0090501" DNA binding|RNA binding|mRNA binding|endonuclease activity|protein serine/threonine phosphatase inhibitor activity|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|mRNA processing|RNA catabolic process|cell population proliferation|RNA splicing|ribonuclease E activity|nuclear speck|negative regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|RNA phosphodiester bond hydrolysis PPP1R9A 325.8820218 387.7131799 264.0508636 0.681046911 -0.554173919 0.229429948 1 1.167576691 0.829427392 55607 protein phosphatase 1 regulatory subunit 9A "GO:0005515,GO:0005737,GO:0005829,GO:0007015,GO:0007568,GO:0008022,GO:0008157,GO:0010976,GO:0014069,GO:0015629,GO:0019722,GO:0019901,GO:0019904,GO:0030175,GO:0030425,GO:0030833,GO:0030864,GO:0031175,GO:0031594,GO:0042802,GO:0043025,GO:0044325,GO:0044326,GO:0045860,GO:0051015,GO:0051020,GO:0051489,GO:0051497,GO:0051823,GO:0051963,GO:0060079,GO:0060999,GO:0061001,GO:0097237,GO:0098871,GO:0098974,GO:0098978,GO:1900272,GO:1900454,GO:1904049,GO:1990761" protein binding|cytoplasm|cytosol|actin filament organization|aging|protein C-terminus binding|protein phosphatase 1 binding|positive regulation of neuron projection development|postsynaptic density|actin cytoskeleton|calcium-mediated signaling|protein kinase binding|protein domain specific binding|filopodium|dendrite|regulation of actin filament polymerization|cortical actin cytoskeleton|neuron projection development|neuromuscular junction|identical protein binding|neuronal cell body|ion channel binding|dendritic spine neck|positive regulation of protein kinase activity|actin filament binding|GTPase binding|regulation of filopodium assembly|negative regulation of stress fiber assembly|regulation of synapse structural plasticity|regulation of synapse assembly|excitatory postsynaptic potential|positive regulation of dendritic spine development|regulation of dendritic spine morphogenesis|cellular response to toxic substance|postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|glutamatergic synapse|negative regulation of long-term synaptic potentiation|positive regulation of long-term synaptic depression|negative regulation of spontaneous neurotransmitter secretion|growth cone lamellipodium PPP1R9B 1697.837489 1800.531888 1595.14309 0.88592882 -0.174737305 0.593586158 1 21.65018714 20.00674396 84687 protein phosphatase 1 regulatory subunit 9B "GO:0000164,GO:0001560,GO:0001932,GO:0001975,GO:0003006,GO:0004672,GO:0004864,GO:0005515,GO:0005654,GO:0005737,GO:0005886,GO:0005912,GO:0006468,GO:0007015,GO:0007050,GO:0007096,GO:0007568,GO:0007612,GO:0008022,GO:0008157,GO:0008380,GO:0014069,GO:0015629,GO:0016358,GO:0016477,GO:0019722,GO:0019900,GO:0021766,GO:0021987,GO:0030027,GO:0030042,GO:0030175,GO:0030308,GO:0030425,GO:0030426,GO:0030864,GO:0031175,GO:0031749,GO:0032515,GO:0032587,GO:0034695,GO:0035094,GO:0035690,GO:0035902,GO:0042127,GO:0043025,GO:0044325,GO:0044326,GO:0044327,GO:0046847,GO:0048545,GO:0050804,GO:0051015,GO:0060179,GO:0061458,GO:0071315,GO:0071364,GO:0071392,GO:0097338,GO:1901653,GO:1903078,GO:1903119,GO:1904372,GO:1904373,GO:1904386,GO:1990778,GO:1990780,GO:2000474" protein phosphatase type 1 complex|regulation of cell growth by extracellular stimulus|regulation of protein phosphorylation|response to amphetamine|developmental process involved in reproduction|protein kinase activity|protein phosphatase inhibitor activity|protein binding|nucleoplasm|cytoplasm|plasma membrane|adherens junction|protein phosphorylation|actin filament organization|cell cycle arrest|regulation of exit from mitosis|aging|learning|protein C-terminus binding|protein phosphatase 1 binding|RNA splicing|postsynaptic density|actin cytoskeleton|dendrite development|cell migration|calcium-mediated signaling|kinase binding|hippocampus development|cerebral cortex development|lamellipodium|actin filament depolymerization|filopodium|negative regulation of cell growth|dendrite|growth cone|cortical actin cytoskeleton|neuron projection development|D2 dopamine receptor binding|negative regulation of phosphoprotein phosphatase activity|ruffle membrane|response to prostaglandin E|response to nicotine|cellular response to drug|response to immobilization stress|regulation of cell population proliferation|neuronal cell body|ion channel binding|dendritic spine neck|dendritic spine head|filopodium assembly|response to steroid hormone|modulation of chemical synaptic transmission|actin filament binding|male mating behavior|reproductive system development|cellular response to morphine|cellular response to epidermal growth factor stimulus|cellular response to estradiol stimulus|response to clozapine|cellular response to peptide|positive regulation of protein localization to plasma membrane|protein localization to actin cytoskeleton|positive regulation of protein localization to actin cortical patch|response to kainic acid|response to L-phenylalanine derivative|protein localization to cell periphery|cytoplasmic side of dendritic spine plasma membrane|regulation of opioid receptor signaling pathway PPP2CA 3965.250599 4112.601584 3817.899614 0.928341717 -0.107272145 0.736815987 1 42.26638836 40.92785042 5515 protein phosphatase 2 catalytic subunit alpha "GO:0000159,GO:0000184,GO:0000188,GO:0000775,GO:0000922,GO:0001932,GO:0004721,GO:0004722,GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0005886,GO:0006275,GO:0006355,GO:0006470,GO:0006672,GO:0006915,GO:0007084,GO:0007498,GO:0008022,GO:0008380,GO:0010033,GO:0010288,GO:0010719,GO:0015630,GO:0016020,GO:0019932,GO:0030111,GO:0030155,GO:0030308,GO:0035970,GO:0040008,GO:0042532,GO:0045121,GO:0045202,GO:0045595,GO:0046872,GO:0046982,GO:0048156,GO:0050811,GO:0051321,GO:0070062,GO:0070262,GO:0071902,GO:0106306,GO:0106307,GO:1904526,GO:1904528" "protein phosphatase type 2A complex|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|inactivation of MAPK activity|chromosome, centromeric region|spindle pole|regulation of protein phosphorylation|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|nucleus|mitochondrion|cytosol|plasma membrane|regulation of DNA replication|regulation of transcription, DNA-templated|protein dephosphorylation|ceramide metabolic process|apoptotic process|mitotic nuclear envelope reassembly|mesoderm development|protein C-terminus binding|RNA splicing|response to organic substance|response to lead ion|negative regulation of epithelial to mesenchymal transition|microtubule cytoskeleton|membrane|second-messenger-mediated signaling|regulation of Wnt signaling pathway|regulation of cell adhesion|negative regulation of cell growth|peptidyl-threonine dephosphorylation|regulation of growth|negative regulation of tyrosine phosphorylation of STAT protein|membrane raft|synapse|regulation of cell differentiation|metal ion binding|protein heterodimerization activity|tau protein binding|GABA receptor binding|meiotic cell cycle|extracellular exosome|peptidyl-serine dephosphorylation|positive regulation of protein serine/threonine kinase activity|protein serine phosphatase activity|protein threonine phosphatase activity|regulation of microtubule binding|positive regulation of microtubule binding" "hsa03015,hsa04071,hsa04114,hsa04136,hsa04140,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|Autophagy - other|Autophagy - animal|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2CB 1239.488868 1146.900244 1332.077491 1.161458896 0.215938098 0.52644573 1 29.8491528 36.16194519 5516 protein phosphatase 2 catalytic subunit beta "GO:0000159,GO:0000775,GO:0000922,GO:0004722,GO:0005515,GO:0005634,GO:0005829,GO:0006470,GO:0008022,GO:0008637,GO:0010288,GO:0010468,GO:0034976,GO:0035970,GO:0042542,GO:0043161,GO:0046580,GO:0046677,GO:0046872,GO:0048156,GO:0070262,GO:0106306,GO:0106307,GO:1904528" "protein phosphatase type 2A complex|chromosome, centromeric region|spindle pole|protein serine/threonine phosphatase activity|protein binding|nucleus|cytosol|protein dephosphorylation|protein C-terminus binding|apoptotic mitochondrial changes|response to lead ion|regulation of gene expression|response to endoplasmic reticulum stress|peptidyl-threonine dephosphorylation|response to hydrogen peroxide|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of Ras protein signal transduction|response to antibiotic|metal ion binding|tau protein binding|peptidyl-serine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of microtubule binding" "hsa03015,hsa04071,hsa04114,hsa04136,hsa04140,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|Autophagy - other|Autophagy - animal|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R1A 5208.719618 5329.53379 5087.905447 0.954662387 -0.066937476 0.83562332 1 46.13264143 45.93820943 5518 protein phosphatase 2 scaffold subunit Aalpha "GO:0000086,GO:0000159,GO:0000184,GO:0000188,GO:0000775,GO:0004722,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006275,GO:0006355,GO:0006470,GO:0006672,GO:0006915,GO:0007059,GO:0007084,GO:0008287,GO:0008380,GO:0010033,GO:0010389,GO:0015630,GO:0016020,GO:0016328,GO:0019888,GO:0019932,GO:0030111,GO:0030155,GO:0030308,GO:0030425,GO:0040008,GO:0042532,GO:0043666,GO:0045595,GO:0046982,GO:0065003,GO:0070062,GO:0097711,GO:1990405" "G2/M transition of mitotic cell cycle|protein phosphatase type 2A complex|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|inactivation of MAPK activity|chromosome, centromeric region|protein serine/threonine phosphatase activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|regulation of DNA replication|regulation of transcription, DNA-templated|protein dephosphorylation|ceramide metabolic process|apoptotic process|chromosome segregation|mitotic nuclear envelope reassembly|protein serine/threonine phosphatase complex|RNA splicing|response to organic substance|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|membrane|lateral plasma membrane|protein phosphatase regulator activity|second-messenger-mediated signaling|regulation of Wnt signaling pathway|regulation of cell adhesion|negative regulation of cell growth|dendrite|regulation of growth|negative regulation of tyrosine phosphorylation of STAT protein|regulation of phosphoprotein phosphatase activity|regulation of cell differentiation|protein heterodimerization activity|protein-containing complex assembly|extracellular exosome|ciliary basal body-plasma membrane docking|protein antigen binding" "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R1B 824.2419779 812.9797307 835.5042252 1.027706096 0.039427741 0.91735123 1 3.876711735 4.155740027 5519 protein phosphatase 2 scaffold subunit Abeta "GO:0000159,GO:0004722,GO:0005515,GO:0005737,GO:0006470,GO:0008287,GO:0019888,GO:0043666,GO:0045121,GO:0060561,GO:0070062,GO:2001241" protein phosphatase type 2A complex|protein serine/threonine phosphatase activity|protein binding|cytoplasm|protein dephosphorylation|protein serine/threonine phosphatase complex|protein phosphatase regulator activity|regulation of phosphoprotein phosphatase activity|membrane raft|apoptotic process involved in morphogenesis|extracellular exosome|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R2A 827.9549058 864.7424851 791.1673265 0.914916683 -0.128287724 0.72724747 1 12.21990967 11.66179686 5520 protein phosphatase 2 regulatory subunit Balpha "GO:0000086,GO:0000159,GO:0000184,GO:0005515,GO:0005654,GO:0005829,GO:0006470,GO:0007084,GO:0019888,GO:0043278,GO:0043666,GO:0044877,GO:0048156,GO:0051721,GO:0070262,GO:0098978" "G2/M transition of mitotic cell cycle|protein phosphatase type 2A complex|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein binding|nucleoplasm|cytosol|protein dephosphorylation|mitotic nuclear envelope reassembly|protein phosphatase regulator activity|response to morphine|regulation of phosphoprotein phosphatase activity|protein-containing complex binding|tau protein binding|protein phosphatase 2A binding|peptidyl-serine dephosphorylation|glutamatergic synapse" "hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04390,hsa04530,hsa04728,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R2D 698.4035214 730.7682972 666.0387456 0.911422606 -0.133807941 0.725684331 1 4.409201365 4.19175276 55844 protein phosphatase 2 regulatory subunit Bdelta "GO:0000159,GO:0000278,GO:0005515,GO:0005829,GO:0010458,GO:0019888,GO:0043666,GO:0051301,GO:0070262" protein phosphatase type 2A complex|mitotic cell cycle|protein binding|cytosol|exit from mitosis|protein phosphatase regulator activity|regulation of phosphoprotein phosphatase activity|cell division|peptidyl-serine dephosphorylation "hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04390,hsa04530,hsa04728,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R3A 593.0868709 704.3794421 481.7942997 0.683998241 -0.547935479 0.162398766 1 4.546817976 3.243982354 5523 protein phosphatase 2 regulatory subunit B''alpha "GO:0000159,GO:0005509,GO:0005515,GO:0006470,GO:0019888,GO:0043666,GO:0061053" protein phosphatase type 2A complex|calcium ion binding|protein binding|protein dephosphorylation|protein phosphatase regulator activity|regulation of phosphoprotein phosphatase activity|somite development "hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R3B-2 58.42751609 20.29911937 96.55591282 4.756655256 2.249947468 0.007726598 0.362374754 0.296789488 1.472536675 28227 protein phosphatase 2 regulatory subunit B''beta PPP2R3C 384.956071 351.1747651 418.737377 1.192390282 0.253856522 0.56485943 1 8.526252627 10.60455756 55012 protein phosphatase 2 regulatory subunit B''gamma "GO:0000226,GO:0001782,GO:0002759,GO:0005515,GO:0005654,GO:0005794,GO:0005813,GO:0005819,GO:0005829,GO:0030865,GO:0032147,GO:0035303,GO:0043029,GO:0045579,GO:0046872,GO:0048536,GO:0051900" microtubule cytoskeleton organization|B cell homeostasis|regulation of antimicrobial humoral response|protein binding|nucleoplasm|Golgi apparatus|centrosome|spindle|cytosol|cortical cytoskeleton organization|activation of protein kinase activity|regulation of dephosphorylation|T cell homeostasis|positive regulation of B cell differentiation|metal ion binding|spleen development|regulation of mitochondrial depolarization "hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5A 623.3440387 550.1061349 696.5819425 1.266268268 0.340583082 0.380017317 1 8.006015825 10.57445754 5525 protein phosphatase 2 regulatory subunit B'alpha "GO:0000159,GO:0000775,GO:0004721,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0006470,GO:0007165,GO:0016020,GO:0019888,GO:0019900,GO:0030018,GO:0031430,GO:0031952,GO:0035307,GO:0043666,GO:0072542,GO:0090219,GO:1903077" "protein phosphatase type 2A complex|chromosome, centromeric region|phosphoprotein phosphatase activity|protein binding|nucleus|cytoplasm|centrosome|cytosol|protein dephosphorylation|signal transduction|membrane|protein phosphatase regulator activity|kinase binding|Z disc|M band|regulation of protein autophosphorylation|positive regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|protein phosphatase activator activity|negative regulation of lipid kinase activity|negative regulation of protein localization to plasma membrane" "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5B 626.4752596 595.7791534 657.1713658 1.103045251 0.141491977 0.717324153 1 10.00136306 11.50716795 5526 protein phosphatase 2 regulatory subunit B'beta "GO:0000159,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0010469,GO:0010976,GO:0014066,GO:0019888,GO:0031334,GO:0031952,GO:0036498,GO:0043666,GO:0045944,GO:0050730,GO:0051091,GO:0051388,GO:0051898,GO:0070317,GO:0071158,GO:0071363,GO:0072542" protein phosphatase type 2A complex|protein binding|nucleus|cytoplasm|cytosol|protein dephosphorylation|regulation of signaling receptor activity|positive regulation of neuron projection development|regulation of phosphatidylinositol 3-kinase signaling|protein phosphatase regulator activity|positive regulation of protein-containing complex assembly|regulation of protein autophosphorylation|IRE1-mediated unfolded protein response|regulation of phosphoprotein phosphatase activity|positive regulation of transcription by RNA polymerase II|regulation of peptidyl-tyrosine phosphorylation|positive regulation of DNA-binding transcription factor activity|positive regulation of neurotrophin TRK receptor signaling pathway|negative regulation of protein kinase B signaling|negative regulation of G0 to G1 transition|positive regulation of cell cycle arrest|cellular response to growth factor stimulus|protein phosphatase activator activity "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5C 2826.158987 2723.126863 2929.19111 1.075671923 0.105238127 0.74161058 1 24.06924415 27.00587264 5527 protein phosphatase 2 regulatory subunit B'gamma "GO:0000159,GO:0000775,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006470,GO:0007165,GO:0008285,GO:0014066,GO:0019888,GO:0031952,GO:0043161,GO:0043666,GO:0051898,GO:0072542" "protein phosphatase type 2A complex|chromosome, centromeric region|protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|protein dephosphorylation|signal transduction|negative regulation of cell population proliferation|regulation of phosphatidylinositol 3-kinase signaling|protein phosphatase regulator activity|regulation of protein autophosphorylation|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of phosphoprotein phosphatase activity|negative regulation of protein kinase B signaling|protein phosphatase activator activity" "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5D 1744.510864 1522.433953 1966.587775 1.291739305 0.369314939 0.257411154 1 25.78792939 34.74619691 5528 protein phosphatase 2 regulatory subunit B'delta "GO:0000159,GO:0004721,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006470,GO:0007165,GO:0007399,GO:0010801,GO:0019888,GO:0031952,GO:0035307,GO:0043666,GO:0072542" protein phosphatase type 2A complex|phosphoprotein phosphatase activity|protein binding|nucleus|nucleoplasm|cytosol|protein dephosphorylation|signal transduction|nervous system development|negative regulation of peptidyl-threonine phosphorylation|protein phosphatase regulator activity|regulation of protein autophosphorylation|positive regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|protein phosphatase activator activity "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5E 1328.001837 1472.70111 1183.302564 0.803491324 -0.31564565 0.349043374 1 8.115234017 6.801397684 5529 protein phosphatase 2 regulatory subunit B'epsilon "GO:0000159,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0007165,GO:0019888,GO:0031952,GO:0043666,GO:0072542" protein phosphatase type 2A complex|protein binding|nucleus|cytoplasm|cytosol|protein dephosphorylation|signal transduction|protein phosphatase regulator activity|regulation of protein autophosphorylation|regulation of phosphoprotein phosphatase activity|protein phosphatase activator activity "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP3CA 1185.145424 1203.737778 1166.553069 0.969108962 -0.04526921 0.89725943 1 12.58828659 12.72492295 5530 protein phosphatase 3 catalytic subunit alpha "GO:0000082,GO:0001975,GO:0004722,GO:0005509,GO:0005515,GO:0005516,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005955,GO:0006470,GO:0006606,GO:0006816,GO:0007223,GO:0007420,GO:0007568,GO:0009898,GO:0014883,GO:0014898,GO:0016018,GO:0016311,GO:0019897,GO:0019899,GO:0030018,GO:0030335,GO:0033173,GO:0033192,GO:0033555,GO:0035562,GO:0036057,GO:0038095,GO:0042060,GO:0042110,GO:0042383,GO:0043197,GO:0043403,GO:0044877,GO:0045785,GO:0045807,GO:0045944,GO:0046676,GO:0046983,GO:0048741,GO:0050774,GO:0051091,GO:0051117,GO:0051592,GO:0060079,GO:0070262,GO:0071333,GO:0097720,GO:0098685,GO:0098978,GO:0099170,GO:0106306,GO:0106307,GO:1903244,GO:1903799,GO:1905205" "G1/S transition of mitotic cell cycle|response to amphetamine|protein serine/threonine phosphatase activity|calcium ion binding|protein binding|calmodulin binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|calcineurin complex|protein dephosphorylation|protein import into nucleus|calcium ion transport|Wnt signaling pathway, calcium modulating pathway|brain development|aging|cytoplasmic side of plasma membrane|transition between fast and slow fiber|cardiac muscle hypertrophy in response to stress|cyclosporin A binding|dephosphorylation|extrinsic component of plasma membrane|enzyme binding|Z disc|positive regulation of cell migration|calcineurin-NFAT signaling cascade|calmodulin-dependent protein phosphatase activity|multicellular organismal response to stress|negative regulation of chromatin binding|slit diaphragm|Fc-epsilon receptor signaling pathway|wound healing|T cell activation|sarcolemma|dendritic spine|skeletal muscle tissue regeneration|protein-containing complex binding|positive regulation of cell adhesion|positive regulation of endocytosis|positive regulation of transcription by RNA polymerase II|negative regulation of insulin secretion|protein dimerization activity|skeletal muscle fiber development|negative regulation of dendrite morphogenesis|positive regulation of DNA-binding transcription factor activity|ATPase binding|response to calcium ion|excitatory postsynaptic potential|peptidyl-serine dephosphorylation|cellular response to glucose stimulus|calcineurin-mediated signaling|Schaffer collateral - CA1 synapse|glutamatergic synapse|postsynaptic modulation of chemical synaptic transmission|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of cardiac muscle hypertrophy in response to stress|negative regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of connective tissue replacement" "hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04728,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05020,hsa05022,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer PPP3CB 1264.540119 1310.308155 1218.772083 0.930141569 -0.104477782 0.759756391 1 14.33934433 13.91215082 5532 protein phosphatase 3 catalytic subunit beta "GO:0001915,GO:0001946,GO:0004722,GO:0005509,GO:0005515,GO:0005516,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005955,GO:0006468,GO:0006470,GO:0007165,GO:0007223,GO:0007507,GO:0007612,GO:0007613,GO:0016311,GO:0017156,GO:0019899,GO:0030018,GO:0030217,GO:0030315,GO:0030346,GO:0031987,GO:0033173,GO:0033192,GO:0034097,GO:0035774,GO:0038095,GO:0042098,GO:0042110,GO:0043029,GO:0045893,GO:0045944,GO:0046983,GO:0048167,GO:0048675,GO:0050796,GO:0097720,GO:0098978,GO:0106306,GO:0106307,GO:1900242" "negative regulation of T cell mediated cytotoxicity|lymphangiogenesis|protein serine/threonine phosphatase activity|calcium ion binding|protein binding|calmodulin binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|calcineurin complex|protein phosphorylation|protein dephosphorylation|signal transduction|Wnt signaling pathway, calcium modulating pathway|heart development|learning|memory|dephosphorylation|calcium-ion regulated exocytosis|enzyme binding|Z disc|T cell differentiation|T-tubule|protein phosphatase 2B binding|locomotion involved in locomotory behavior|calcineurin-NFAT signaling cascade|calmodulin-dependent protein phosphatase activity|response to cytokine|positive regulation of insulin secretion involved in cellular response to glucose stimulus|Fc-epsilon receptor signaling pathway|T cell proliferation|T cell activation|T cell homeostasis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of synaptic plasticity|axon extension|regulation of insulin secretion|calcineurin-mediated signaling|glutamatergic synapse|protein serine phosphatase activity|protein threonine phosphatase activity|regulation of synaptic vesicle endocytosis" "hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04728,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05020,hsa05022,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer PPP3CC 241.0589695 213.1407534 268.9771857 1.261969762 0.335677342 0.510635533 1 4.806245433 6.326606497 5533 protein phosphatase 3 catalytic subunit gamma "GO:0005515,GO:0005516,GO:0005737,GO:0005739,GO:0005829,GO:0005955,GO:0006470,GO:0007420,GO:0033173,GO:0033192,GO:0046872,GO:0097720,GO:0098793,GO:0098978,GO:0106306,GO:0106307,GO:1900244,GO:1900740" protein binding|calmodulin binding|cytoplasm|mitochondrion|cytosol|calcineurin complex|protein dephosphorylation|brain development|calcineurin-NFAT signaling cascade|calmodulin-dependent protein phosphatase activity|metal ion binding|calcineurin-mediated signaling|presynapse|glutamatergic synapse|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of synaptic vesicle endocytosis|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway "hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04728,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05020,hsa05022,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer PPP3R1 1329.238242 1321.472671 1337.003813 1.011752905 0.016856991 0.962507915 1 22.13225162 23.35694234 5534 "protein phosphatase 3 regulatory subunit B, alpha" "GO:0004723,GO:0005509,GO:0005515,GO:0005516,GO:0005654,GO:0005739,GO:0005829,GO:0005955,GO:0006470,GO:0007223,GO:0008597,GO:0016018,GO:0019902,GO:0019904,GO:0033173,GO:0038095,GO:0042383,GO:0043666,GO:0045944,GO:1900740" "calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding|protein binding|calmodulin binding|nucleoplasm|mitochondrion|cytosol|calcineurin complex|protein dephosphorylation|Wnt signaling pathway, calcium modulating pathway|calcium-dependent protein serine/threonine phosphatase regulator activity|cyclosporin A binding|phosphatase binding|protein domain specific binding|calcineurin-NFAT signaling cascade|Fc-epsilon receptor signaling pathway|sarcolemma|regulation of phosphoprotein phosphatase activity|positive regulation of transcription by RNA polymerase II|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" "hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05020,hsa05022,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer PPP4C 2173.061299 2193.319848 2152.80275 0.981527046 -0.026900074 0.934594207 1 75.67024027 77.4717406 5531 protein phosphatase 4 catalytic subunit "GO:0004704,GO:0004722,GO:0005515,GO:0005654,GO:0005815,GO:0005829,GO:0005886,GO:0006470,GO:0010569,GO:0030289,GO:0038061,GO:0046872,GO:0106306,GO:0106307" NF-kappaB-inducing kinase activity|protein serine/threonine phosphatase activity|protein binding|nucleoplasm|microtubule organizing center|cytosol|plasma membrane|protein dephosphorylation|regulation of double-strand break repair via homologous recombination|protein phosphatase 4 complex|NIK/NF-kappaB signaling|metal ion binding|protein serine phosphatase activity|protein threonine phosphatase activity hsa04922 Glucagon signaling pathway PPP4R1 2304.506262 2355.712803 2253.299721 0.95652565 -0.064124438 0.842178934 1 28.73519822 28.6699376 9989 protein phosphatase 4 regulatory subunit 1 "GO:0004721,GO:0004722,GO:0005515,GO:0006468,GO:0006470,GO:0007165,GO:0008287,GO:0019888,GO:0030289,GO:0043666" phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|protein phosphorylation|protein dephosphorylation|signal transduction|protein serine/threonine phosphatase complex|protein phosphatase regulator activity|protein phosphatase 4 complex|regulation of phosphoprotein phosphatase activity PPP4R2 1807.087033 1927.401384 1686.772681 0.875153819 -0.192391485 0.554235142 1 18.08710036 16.51084385 151987 protein phosphatase 4 regulatory subunit 2 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006397,GO:0006464,GO:0006470,GO:0008380,GO:0010569,GO:0019888,GO:0030289,GO:0030674,GO:0043666" protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|mRNA processing|cellular protein modification process|protein dephosphorylation|RNA splicing|regulation of double-strand break repair via homologous recombination|protein phosphatase regulator activity|protein phosphatase 4 complex|protein-macromolecule adaptor activity|regulation of phosphoprotein phosphatase activity PPP4R3A 1331.683836 1353.951262 1309.41641 0.967107492 -0.048251843 0.88816721 1 17.87613529 18.03284751 55671 protein phosphatase 4 regulatory subunit 3A "GO:0005654,GO:0005815,GO:0005829,GO:0016607" nucleoplasm|microtubule organizing center|cytosol|nuclear speck hsa04922 Glucagon signaling pathway PPP4R3B 1632.14074 1586.376179 1677.905301 1.057696985 0.080926375 0.806693301 1 13.80013003 15.22510775 57223 protein phosphatase 4 regulatory subunit 3B "GO:0005654,GO:0005737,GO:0005813,GO:0006470,GO:0016607,GO:0019216,GO:0030289,GO:0045722" nucleoplasm|cytoplasm|centrosome|protein dephosphorylation|nuclear speck|regulation of lipid metabolic process|protein phosphatase 4 complex|positive regulation of gluconeogenesis hsa04922 Glucagon signaling pathway PPP4R4 470.2447855 490.2237327 450.2658384 0.918490494 -0.122663305 0.771350486 1 5.117086285 4.902451837 57718 protein phosphatase 4 regulatory subunit 4 "GO:0001835,GO:0005515,GO:0005737,GO:0005829,GO:0008287,GO:0019888,GO:0032515,GO:0080163" blastocyst hatching|protein binding|cytoplasm|cytosol|protein serine/threonine phosphatase complex|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|regulation of protein serine/threonine phosphatase activity PPP5C 1288.040729 1266.665049 1309.41641 1.033751118 0.047888889 0.889626683 1 29.74136123 32.06954245 5536 protein phosphatase 5 catalytic subunit "GO:0000165,GO:0000278,GO:0001933,GO:0001965,GO:0003723,GO:0004721,GO:0004722,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006281,GO:0006351,GO:0006470,GO:0008017,GO:0008289,GO:0010288,GO:0016576,GO:0016791,GO:0032991,GO:0035970,GO:0042802,GO:0043123,GO:0043204,GO:0043231,GO:0043278,GO:0043531,GO:0044877,GO:0046872,GO:0048156,GO:0051879,GO:0070262,GO:0070301,GO:0071276,GO:0101031,GO:0106306,GO:0106307,GO:1901215,GO:1904550,GO:1990635,GO:2000324" "MAPK cascade|mitotic cell cycle|negative regulation of protein phosphorylation|G-protein alpha-subunit binding|RNA binding|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|DNA repair|transcription, DNA-templated|protein dephosphorylation|microtubule binding|lipid binding|response to lead ion|histone dephosphorylation|phosphatase activity|protein-containing complex|peptidyl-threonine dephosphorylation|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|perikaryon|intracellular membrane-bounded organelle|response to morphine|ADP binding|protein-containing complex binding|metal ion binding|tau protein binding|Hsp90 protein binding|peptidyl-serine dephosphorylation|cellular response to hydrogen peroxide|cellular response to cadmium ion|chaperone complex|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of neuron death|response to arachidonic acid|proximal dendrite|positive regulation of glucocorticoid receptor signaling pathway" hsa04010 MAPK signaling pathway PPP5D1 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.01853062 0.093816986 100506012 PPP5 tetratricopeptide repeat domain containing 1 PPP6C 1670.889938 1642.198757 1699.581119 1.034942397 0.049550473 0.881384526 1 17.63978233 19.04255989 5537 protein phosphatase 6 catalytic subunit "GO:0000082,GO:0000139,GO:0004722,GO:0005515,GO:0005739,GO:0005829,GO:0006470,GO:0045087,GO:0046872,GO:0048208,GO:0106306,GO:0106307" G1/S transition of mitotic cell cycle|Golgi membrane|protein serine/threonine phosphatase activity|protein binding|mitochondrion|cytosol|protein dephosphorylation|innate immune response|metal ion binding|COPII vesicle coating|protein serine phosphatase activity|protein threonine phosphatase activity PPP6R1 2826.497718 2779.964397 2873.031039 1.033477638 0.047507172 0.882360884 1 35.34020823 38.09659121 22870 protein phosphatase 6 regulatory subunit 1 "GO:0000139,GO:0005515,GO:0005634,GO:0005829,GO:0019888,GO:0019903,GO:0031267,GO:0043666,GO:0048208" Golgi membrane|protein binding|nucleus|cytosol|protein phosphatase regulator activity|protein phosphatase binding|small GTPase binding|regulation of phosphoprotein phosphatase activity|COPII vesicle coating PPP6R2 1153.863897 1287.979124 1019.748671 0.791743167 -0.336895583 0.327773318 1 13.8790636 11.46200041 9701 protein phosphatase 6 regulatory subunit 2 "GO:0005515,GO:0005634,GO:0005829,GO:0019888,GO:0019903,GO:0043231,GO:0043666" protein binding|nucleus|cytosol|protein phosphatase regulator activity|protein phosphatase binding|intracellular membrane-bounded organelle|regulation of phosphoprotein phosphatase activity PPP6R3 3669.115545 3603.093688 3735.137403 1.036647317 0.051925151 0.871129539 1 19.05638934 20.6057096 55291 protein phosphatase 6 regulatory subunit 3 "GO:0000139,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0019888,GO:0019903,GO:0043666,GO:0048208" Golgi membrane|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein phosphatase regulator activity|protein phosphatase binding|regulation of phosphoprotein phosphatase activity|COPII vesicle coating PPRC1 3312.05295 3710.67902 2913.42688 0.785146563 -0.348966108 0.272742287 1 28.72272687 23.52297961 23082 PPARG related coactivator 1 "GO:0003723,GO:0005634,GO:0005654,GO:0007005,GO:0008134,GO:0030374,GO:0045944,GO:0051091" RNA binding|nucleus|nucleoplasm|mitochondrion organization|transcription factor binding|nuclear receptor coactivator activity|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity PPT1 2945.675372 3080.391364 2810.95938 0.912533197 -0.132051051 0.678623169 1 44.13322648 42.00783325 5538 palmitoyl-protein thioesterase 1 "GO:0002084,GO:0005515,GO:0005576,GO:0005634,GO:0005764,GO:0005794,GO:0005829,GO:0006898,GO:0006907,GO:0007042,GO:0007399,GO:0007420,GO:0007601,GO:0008021,GO:0008474,GO:0015031,GO:0016020,GO:0016042,GO:0016290,GO:0016790,GO:0018215,GO:0030149,GO:0030163,GO:0030308,GO:0030424,GO:0031579,GO:0035727,GO:0043066,GO:0043202,GO:0043231,GO:0043524,GO:0045121,GO:0046949,GO:0048260,GO:0048549,GO:0048666,GO:0050803,GO:0050896,GO:0070062,GO:0120146" protein depalmitoylation|protein binding|extracellular region|nucleus|lysosome|Golgi apparatus|cytosol|receptor-mediated endocytosis|pinocytosis|lysosomal lumen acidification|nervous system development|brain development|visual perception|synaptic vesicle|palmitoyl-(protein) hydrolase activity|protein transport|membrane|lipid catabolic process|palmitoyl-CoA hydrolase activity|thiolester hydrolase activity|protein phosphopantetheinylation|sphingolipid catabolic process|protein catabolic process|negative regulation of cell growth|axon|membrane raft organization|lysophosphatidic acid binding|negative regulation of apoptotic process|lysosomal lumen|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|membrane raft|fatty-acyl-CoA biosynthetic process|positive regulation of receptor-mediated endocytosis|positive regulation of pinocytosis|neuron development|regulation of synapse structure or activity|response to stimulus|extracellular exosome|sulfatide binding "hsa00062,hsa04142" Fatty acid elongation|Lysosome PPT2 866.1575314 849.5181455 882.7969172 1.039173703 0.055436828 0.881164847 1 21.45890132 23.26009909 9374 palmitoyl-protein thioesterase 2 "GO:0005764,GO:0008474,GO:0016790,GO:0018215,GO:0043202,GO:0043231,GO:0046949,GO:0070062,GO:0098599,GO:0098734" lysosome|palmitoyl-(protein) hydrolase activity|thiolester hydrolase activity|protein phosphopantetheinylation|lysosomal lumen|intracellular membrane-bounded organelle|fatty-acyl-CoA biosynthetic process|extracellular exosome|palmitoyl hydrolase activity|macromolecule depalmitoylation "hsa00062,hsa04142" Fatty acid elongation|Lysosome PPTC7 756.4220367 824.1442463 688.6998272 0.835654475 -0.259021553 0.486573827 1 8.805906892 7.675678256 160760 protein phosphatase targeting COQ7 "GO:0004722,GO:0005515,GO:0005739,GO:0005759,GO:0010795,GO:0046872,GO:0070262,GO:0106306,GO:0106307" protein serine/threonine phosphatase activity|protein binding|mitochondrion|mitochondrial matrix|regulation of ubiquinone biosynthetic process|metal ion binding|peptidyl-serine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity PPWD1 900.8968857 833.27885 968.5149215 1.162293896 0.216974913 0.546628481 1 18.97600455 23.00576413 23398 peptidylprolyl isomerase domain and WD repeat containing 1 "GO:0000398,GO:0000413,GO:0003755,GO:0005654,GO:0016018,GO:0016604,GO:0071013" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|nucleoplasm|cyclosporin A binding|nuclear body|catalytic step 2 spliceosome" PQBP1 1745.04655 1727.455058 1762.638041 1.020366946 0.029088069 0.930679201 1 69.60183341 74.07863832 10084 polyglutamine binding protein 1 "GO:0000380,GO:0000398,GO:0002218,GO:0002230,GO:0003677,GO:0003690,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0010494,GO:0016604,GO:0016607,GO:0031175,GO:0032481,GO:0043021,GO:0043484,GO:0045087,GO:0045893,GO:0048814,GO:0051607,GO:0071360,GO:0071598" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|activation of innate immune response|positive regulation of defense response to virus by host|DNA binding|double-stranded DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|cytoplasmic stress granule|nuclear body|nuclear speck|neuron projection development|positive regulation of type I interferon production|ribonucleoprotein complex binding|regulation of RNA splicing|innate immune response|positive regulation of transcription, DNA-templated|regulation of dendrite morphogenesis|defense response to virus|cellular response to exogenous dsRNA|neuronal ribonucleoprotein granule" hsa03040 Spliceosome PRADC1 202.4258164 198.9313698 205.9202631 1.035132183 0.049815007 0.935658073 1 9.243277149 9.980164876 84279 protease associated domain containing 1 "GO:0005515,GO:0005576" protein binding|extracellular region PRAF2 1726.09988 1577.241575 1874.958185 1.188757775 0.249454777 0.444896995 1 63.39819174 78.6115159 11230 PRA1 domain family member 2 "GO:0005515,GO:0010008,GO:0015031,GO:0015813,GO:0016020,GO:0016021" protein binding|endosome membrane|protein transport|L-glutamate transmembrane transport|membrane|integral component of membrane PRAG1 443.8356414 503.4181603 384.2531225 0.763288162 -0.389700278 0.355627781 1 4.691141466 3.73493447 157285 "PEAK1 related, kinase-activating pseudokinase 1" "GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005925,GO:0006468,GO:0008360,GO:0008593,GO:0010977,GO:0016477,GO:0035025,GO:0042802,GO:2000145" protein kinase activity|protein binding|ATP binding|nucleus|cytoplasm|focal adhesion|protein phosphorylation|regulation of cell shape|regulation of Notch signaling pathway|negative regulation of neuron projection development|cell migration|positive regulation of Rho protein signal transduction|identical protein binding|regulation of cell motility PRB3 18.9724021 17.25425146 20.69055275 1.199156787 0.2620203 0.858856573 1 0.793702968 0.992772877 5544 proline rich protein BstNI subfamily 3 "GO:0005515,GO:0005576,GO:0008150,GO:0050829" protein binding|extracellular region|biological_process|defense response to Gram-negative bacterium PRC1 5394.638915 5477.717361 5311.56047 0.969666764 -0.044439059 0.890844931 1 90.1908518 91.22228122 9055 protein regulator of cytokinesis 1 "GO:0000022,GO:0000226,GO:0000922,GO:0001578,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005819,GO:0005829,GO:0005876,GO:0005886,GO:0008017,GO:0008284,GO:0015630,GO:0019894,GO:0019901,GO:0030496,GO:0032465,GO:0045171,GO:0051256,GO:0051301,GO:0070938,GO:1990023" mitotic spindle elongation|microtubule cytoskeleton organization|spindle pole|microtubule bundle formation|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|spindle|cytosol|spindle microtubule|plasma membrane|microtubule binding|positive regulation of cell population proliferation|microtubule cytoskeleton|kinesin binding|protein kinase binding|midbody|regulation of cytokinesis|intercellular bridge|mitotic spindle midzone assembly|cell division|contractile ring|mitotic spindle midzone PRCC 1243.339367 1342.786746 1143.891988 0.851879117 -0.231279371 0.497145115 1 26.13659171 23.2243119 5546 proline rich mitotic checkpoint control factor "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0007093,GO:0016607" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|mitotic cell cycle checkpoint|nuclear speck" "hsa05202,hsa05211" Transcriptional misregulation in cancer|Renal cell carcinoma PRCP 2232.617094 2290.755621 2174.478567 0.949240743 -0.07515407 0.815500089 1 31.77723662 31.46360115 5547 prolylcarboxypeptidase "GO:0002155,GO:0002353,GO:0003085,GO:0004185,GO:0005515,GO:0005886,GO:0006508,GO:0007597,GO:0008239,GO:0035577,GO:0042593,GO:0043231,GO:0043312,GO:0043535,GO:0045178,GO:0060055,GO:0070062,GO:0097009,GO:0101003,GO:2000377" "regulation of thyroid hormone mediated signaling pathway|plasma kallikrein-kinin cascade|negative regulation of systemic arterial blood pressure|serine-type carboxypeptidase activity|protein binding|plasma membrane|proteolysis|blood coagulation, intrinsic pathway|dipeptidyl-peptidase activity|azurophil granule membrane|glucose homeostasis|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of blood vessel endothelial cell migration|basal part of cell|angiogenesis involved in wound healing|extracellular exosome|energy homeostasis|ficolin-1-rich granule membrane|regulation of reactive oxygen species metabolic process" "hsa04614,hsa04974" Renin-angiotensin system|Protein digestion and absorption PRDM1 143.2951057 197.9164138 88.67379749 0.448036602 -1.158311499 0.055659892 1 1.190754117 0.556482506 639 PR/SET domain 1 "GO:0000122,GO:0000978,GO:0001227,GO:0002250,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0008168,GO:0010468,GO:0032259,GO:0032823,GO:0033082,GO:0042826,GO:0045087,GO:0045165,GO:0046872,GO:0051136,GO:1990837,GO:1990841" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|adaptive immune response|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|methyltransferase activity|regulation of gene expression|methylation|regulation of natural killer cell differentiation|regulation of extrathymic T cell differentiation|histone deacetylase binding|innate immune response|cell fate commitment|metal ion binding|regulation of NK T cell differentiation|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" zf-C2H2 PRDM10 367.7409137 386.698224 348.7836035 0.901952949 -0.148875919 0.741775813 1 2.949977535 2.775354866 56980 PR/SET domain 10 "GO:0000785,GO:0003677,GO:0005515,GO:0005634,GO:0008168,GO:0010468,GO:0017053,GO:0032259,GO:0045944,GO:0046872" chromatin|DNA binding|protein binding|nucleus|methyltransferase activity|regulation of gene expression|transcription repressor complex|methylation|positive regulation of transcription by RNA polymerase II|metal ion binding PRDM11 209.2457169 227.3501369 191.1412968 0.840735349 -0.250276361 0.642076775 1 0.802011729 0.703324842 56981 PR/SET domain 11 "GO:0003682,GO:0005515,GO:0005634,GO:0005829,GO:0008168,GO:0010468,GO:0030308,GO:0032259,GO:0043408,GO:0045892,GO:0045893,GO:0051726,GO:2000271" "chromatin binding|protein binding|nucleus|cytosol|methyltransferase activity|regulation of gene expression|negative regulation of cell growth|methylation|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of cell cycle|positive regulation of fibroblast apoptotic process" PRDM12 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.186697116 0.084018828 59335 PR/SET domain 12 "GO:0000122,GO:0003677,GO:0005634,GO:0005654,GO:0008168,GO:0010468,GO:0019233,GO:0022008,GO:0031175,GO:0032259,GO:0046872,GO:0050965,GO:0051574,GO:1900111,GO:1990226" negative regulation of transcription by RNA polymerase II|DNA binding|nucleus|nucleoplasm|methyltransferase activity|regulation of gene expression|sensory perception of pain|neurogenesis|neuron projection development|methylation|metal ion binding|detection of temperature stimulus involved in sensory perception of pain|positive regulation of histone H3-K9 methylation|positive regulation of histone H3-K9 dimethylation|histone methyltransferase binding PRDM15 342.9608455 376.5486643 309.3730268 0.821601711 -0.283488909 0.534194169 1 1.607320814 1.377462655 63977 PR/SET domain 15 "GO:0000978,GO:0001228,GO:0005634,GO:0005654,GO:0006357,GO:0007275,GO:0008168,GO:0016604,GO:0032259,GO:0043409,GO:0045944,GO:0046872,GO:0090263,GO:1990841,GO:2000035" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|methyltransferase activity|nuclear body|methylation|negative regulation of MAPK cascade|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of canonical Wnt signaling pathway|promoter-specific chromatin binding|regulation of stem cell division" PRDM2 518.8372249 478.0442611 559.6301886 1.170666054 0.227329589 0.576314137 1 2.062111863 2.518031597 7799 PR/SET domain 2 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005634,GO:0005654,GO:0005794,GO:0006355,GO:0006357,GO:0008168,GO:0008270,GO:0008340,GO:0010468,GO:0032259,GO:0043565,GO:0045944" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|Golgi apparatus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|methyltransferase activity|zinc ion binding|determination of adult lifespan|regulation of gene expression|methylation|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II" hsa00310 Lysine degradation PRDM4 1429.554342 1342.786746 1516.321937 1.129235109 0.175345889 0.599919128 1 15.65908626 18.44449285 11108 PR/SET domain 4 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005737,GO:0006366,GO:0008168,GO:0010468,GO:0035097,GO:0043985,GO:0045944,GO:0046872,GO:1990226,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|cytoplasm|transcription by RNA polymerase II|methyltransferase activity|regulation of gene expression|histone methyltransferase complex|histone H4-R3 methylation|positive regulation of transcription by RNA polymerase II|metal ion binding|histone methyltransferase binding|sequence-specific double-stranded DNA binding" hsa04722 Neurotrophin signaling pathway PRDM6 19.94282075 16.23929549 23.646346 1.456118956 0.542128219 0.650882351 1 0.080696922 0.122565927 93166 PR/SET domain 6 "GO:0000122,GO:0005515,GO:0005634,GO:0006325,GO:0008168,GO:0010468,GO:0022008,GO:0032259,GO:0042802,GO:0046872,GO:0051151" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|chromatin organization|methyltransferase activity|regulation of gene expression|neurogenesis|methylation|identical protein binding|metal ion binding|negative regulation of smooth muscle cell differentiation hsa00310 Lysine degradation zf-C2H2 PRDM8 276.9941508 177.6172945 376.3710071 2.118999776 1.083383435 0.026516732 0.720384826 1.629653871 3.601987597 56978 PR/SET domain 8 "GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0008168,GO:0014003,GO:0032259,GO:0046872" "DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|methyltransferase activity|oligodendrocyte development|methylation|metal ion binding" PRDX1 8948.486689 8980.330408 8916.64297 0.992908119 -0.010267875 0.975790993 1 355.8858016 368.5832993 5052 peroxiredoxin 1 "GO:0001501,GO:0001895,GO:0003723,GO:0004601,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0006979,GO:0008283,GO:0008379,GO:0019430,GO:0030101,GO:0033554,GO:0034599,GO:0042470,GO:0042744,GO:0045296,GO:0045321,GO:0045454,GO:0055114,GO:0070062" skeletal system development|retina homeostasis|RNA binding|peroxidase activity|protein binding|extracellular space|nucleus|cytoplasm|cytosol|response to oxidative stress|cell population proliferation|thioredoxin peroxidase activity|removal of superoxide radicals|natural killer cell activation|cellular response to stress|cellular response to oxidative stress|melanosome|hydrogen peroxide catabolic process|cadherin binding|leukocyte activation|cell redox homeostasis|oxidation-reduction process|extracellular exosome "hsa04146,hsa05146" Peroxisome|Amoebiasis PRDX2 3243.385808 3125.049427 3361.722189 1.075734086 0.105321498 0.74108335 1 171.1056529 191.9929217 7001 peroxiredoxin 2 "GO:0000187,GO:0002536,GO:0005515,GO:0005737,GO:0005829,GO:0006979,GO:0008379,GO:0010310,GO:0016209,GO:0019430,GO:0030194,GO:0031665,GO:0032088,GO:0032496,GO:0033554,GO:0034599,GO:0042098,GO:0042744,GO:0042981,GO:0043066,GO:0045321,GO:0045454,GO:0045581,GO:0048538,GO:0048872,GO:0055114,GO:0070062,GO:2001240" activation of MAPK activity|respiratory burst involved in inflammatory response|protein binding|cytoplasm|cytosol|response to oxidative stress|thioredoxin peroxidase activity|regulation of hydrogen peroxide metabolic process|antioxidant activity|removal of superoxide radicals|positive regulation of blood coagulation|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|response to lipopolysaccharide|cellular response to stress|cellular response to oxidative stress|T cell proliferation|hydrogen peroxide catabolic process|regulation of apoptotic process|negative regulation of apoptotic process|leukocyte activation|cell redox homeostasis|negative regulation of T cell differentiation|thymus development|homeostasis of number of cells|oxidation-reduction process|extracellular exosome|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand PRDX3 2316.121594 2341.503419 2290.739768 0.978320061 -0.031621569 0.922551466 1 76.3611641 77.92367554 10935 peroxiredoxin 3 "GO:0001893,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005769,GO:0005829,GO:0006915,GO:0006979,GO:0007005,GO:0008022,GO:0008284,GO:0008379,GO:0008785,GO:0018171,GO:0019900,GO:0019901,GO:0030099,GO:0032496,GO:0032991,GO:0033673,GO:0034599,GO:0034614,GO:0042542,GO:0042744,GO:0042802,GO:0043027,GO:0043066,GO:0043154,GO:0045454,GO:0051092,GO:0051881,GO:0098869" maternal placenta development|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|early endosome|cytosol|apoptotic process|response to oxidative stress|mitochondrion organization|protein C-terminus binding|positive regulation of cell population proliferation|thioredoxin peroxidase activity|alkyl hydroperoxide reductase activity|peptidyl-cysteine oxidation|kinase binding|protein kinase binding|myeloid cell differentiation|response to lipopolysaccharide|protein-containing complex|negative regulation of kinase activity|cellular response to oxidative stress|cellular response to reactive oxygen species|response to hydrogen peroxide|hydrogen peroxide catabolic process|identical protein binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cell redox homeostasis|positive regulation of NF-kappaB transcription factor activity|regulation of mitochondrial membrane potential|cellular oxidant detoxification PRDX4 1916.001804 2132.42249 1699.581119 0.797018943 -0.327314081 0.311438021 1 112.9703728 93.91806474 10549 peroxiredoxin 4 "GO:0005515,GO:0005576,GO:0005634,GO:0005783,GO:0005790,GO:0005829,GO:0006979,GO:0007252,GO:0007283,GO:0008379,GO:0008584,GO:0018401,GO:0022417,GO:0030198,GO:0033554,GO:0034774,GO:0042744,GO:0043312,GO:0045454,GO:0055114,GO:0070062,GO:0072593,GO:0098869,GO:1904813,GO:2000255" protein binding|extracellular region|nucleus|endoplasmic reticulum|smooth endoplasmic reticulum|cytosol|response to oxidative stress|I-kappaB phosphorylation|spermatogenesis|thioredoxin peroxidase activity|male gonad development|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|protein maturation by protein folding|extracellular matrix organization|cellular response to stress|secretory granule lumen|hydrogen peroxide catabolic process|neutrophil degranulation|cell redox homeostasis|oxidation-reduction process|extracellular exosome|reactive oxygen species metabolic process|cellular oxidant detoxification|ficolin-1-rich granule lumen|negative regulation of male germ cell proliferation PRDX5 5149.594105 5631.990669 4667.197541 0.828694118 -0.271088412 0.399312614 1 331.6749522 286.6968104 25824 peroxiredoxin 5 "GO:0001016,GO:0004601,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006915,GO:0006954,GO:0006979,GO:0008379,GO:0016480,GO:0031410,GO:0034599,GO:0034614,GO:0042744,GO:0043027,GO:0043066,GO:0043154,GO:0043231,GO:0045454,GO:0048471,GO:0055114,GO:0070062,GO:0098869" RNA polymerase III transcription regulatory region sequence-specific DNA binding|peroxidase activity|protein binding|extracellular space|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|peroxisome|peroxisomal matrix|cytosol|apoptotic process|inflammatory response|response to oxidative stress|thioredoxin peroxidase activity|negative regulation of transcription by RNA polymerase III|cytoplasmic vesicle|cellular response to oxidative stress|cellular response to reactive oxygen species|hydrogen peroxide catabolic process|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|intracellular membrane-bounded organelle|cell redox homeostasis|perinuclear region of cytoplasm|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification hsa04146 Peroxisome PRDX6 4207.645688 4417.088374 3998.203002 0.905167084 -0.143743973 0.652643099 1 132.3727477 124.9807901 9588 peroxiredoxin 6 "GO:0004602,GO:0004623,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006979,GO:0016020,GO:0031625,GO:0034599,GO:0035578,GO:0042744,GO:0042802,GO:0043312,GO:0045296,GO:0045454,GO:0046475,GO:0047184,GO:0047499,GO:0048026,GO:0048471,GO:0051920,GO:0055114,GO:0070062,GO:0098869,GO:0102567,GO:0102568" "glutathione peroxidase activity|phospholipase A2 activity|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|cytosol|response to oxidative stress|membrane|ubiquitin protein ligase binding|cellular response to oxidative stress|azurophil granule lumen|hydrogen peroxide catabolic process|identical protein binding|neutrophil degranulation|cadherin binding|cell redox homeostasis|glycerophospholipid catabolic process|1-acylglycerophosphocholine O-acyltransferase activity|calcium-independent phospholipase A2 activity|positive regulation of mRNA splicing, via spliceosome|perinuclear region of cytoplasm|peroxiredoxin activity|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" hsa00480 Glutathione metabolism PREB 962.794354 956.0885222 969.5001859 1.014027638 0.020096974 0.957968349 1 22.76563741 24.07939308 10113 prolactin regulatory element binding "GO:0000139,GO:0003400,GO:0003677,GO:0005085,GO:0005096,GO:0005515,GO:0005634,GO:0005789,GO:0006888,GO:0009306,GO:0016020,GO:0030176,GO:0032527,GO:0036498,GO:0043547,GO:0048208,GO:0051020,GO:0070971" Golgi membrane|regulation of COPII vesicle coating|DNA binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleus|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|membrane|integral component of endoplasmic reticulum membrane|protein exit from endoplasmic reticulum|IRE1-mediated unfolded protein response|positive regulation of GTPase activity|COPII vesicle coating|GTPase binding|endoplasmic reticulum exit site hsa04141 Protein processing in endoplasmic reticulum PRELID1 2560.514182 2681.513668 2439.514695 0.909752847 -0.136453433 0.669262601 1 110.7742312 105.1182442 27166 PRELI domain containing 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005758,GO:0006915,GO:0006955,GO:0007275,GO:0010917,GO:0010950,GO:0015914,GO:0032991,GO:0042981,GO:0043066,GO:0045580,GO:0051881,GO:0070234,GO:0090201,GO:0097035,GO:0120009,GO:1901857,GO:1990050,GO:2001140" protein binding|nucleoplasm|mitochondrion|mitochondrial intermembrane space|apoptotic process|immune response|multicellular organism development|negative regulation of mitochondrial membrane potential|positive regulation of endopeptidase activity|phospholipid transport|protein-containing complex|regulation of apoptotic process|negative regulation of apoptotic process|regulation of T cell differentiation|regulation of mitochondrial membrane potential|positive regulation of T cell apoptotic process|negative regulation of release of cytochrome c from mitochondria|regulation of membrane lipid distribution|intermembrane lipid transfer|positive regulation of cellular respiration|phosphatidic acid transfer activity|positive regulation of phospholipid transport PRELID2 239.0505843 311.5914823 166.5096864 0.53438459 -0.90404969 0.076363056 1 1.03373571 0.57620812 153768 PRELI domain containing 2 "GO:0005758,GO:0015914,GO:0120009,GO:1990050" mitochondrial intermembrane space|phospholipid transport|intermembrane lipid transfer|phosphatidic acid transfer activity PRELID3A 110.4750618 109.6152446 111.3348791 1.015687914 0.022457179 0.988309179 1 2.282740723 2.418425986 10650 PRELI domain containing 3A "GO:0005515,GO:0005758,GO:0015914,GO:0120009,GO:1990050" protein binding|mitochondrial intermembrane space|phospholipid transport|intermembrane lipid transfer|phosphatidic acid transfer activity PRELID3B 2754.943322 2636.855606 2873.031039 1.089567071 0.123755008 0.698135141 1 53.35494773 60.63796219 51012 PRELI domain containing 3B "GO:0005758,GO:0015914,GO:0120009,GO:1990050" mitochondrial intermembrane space|phospholipid transport|intermembrane lipid transfer|phosphatidic acid transfer activity PREP 1228.074449 1444.282343 1011.866556 0.700601625 -0.513333761 0.13232625 1 5.896163594 4.308802565 5550 prolyl endopeptidase "GO:0004175,GO:0004252,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008236,GO:0016020,GO:0070012" endopeptidase activity|serine-type endopeptidase activity|protein binding|nucleus|cytoplasm|cytosol|proteolysis|serine-type peptidase activity|membrane|oligopeptidase activity hsa04614 Renin-angiotensin system PREPL 924.968316 929.699667 920.2369651 0.989821765 -0.01475933 0.970370985 1 6.388008188 6.595358283 9581 prolyl endopeptidase like "GO:0004252,GO:0005634,GO:0005794,GO:0005802,GO:0005829,GO:0005856,GO:0006508,GO:0008233,GO:0042147,GO:0043001,GO:2000300" "serine-type endopeptidase activity|nucleus|Golgi apparatus|trans-Golgi network|cytosol|cytoskeleton|proteolysis|peptidase activity|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport|regulation of synaptic vesicle exocytosis" PREX1 1959.547425 2684.558536 1234.536314 0.459865671 -1.120715589 0.00058974 0.06551913 20.25374934 9.71521356 57580 "phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1" "GO:0005085,GO:0005096,GO:0005515,GO:0005543,GO:0005829,GO:0005886,GO:0006801,GO:0007186,GO:0019899,GO:0030041,GO:0030217,GO:0030335,GO:0030426,GO:0030593,GO:0030833,GO:0035556,GO:0042119,GO:0043065,GO:0043198,GO:0043547,GO:0048471,GO:0050773,GO:0051056,GO:1900026" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|phospholipid binding|cytosol|plasma membrane|superoxide metabolic process|G protein-coupled receptor signaling pathway|enzyme binding|actin filament polymerization|T cell differentiation|positive regulation of cell migration|growth cone|neutrophil chemotaxis|regulation of actin filament polymerization|intracellular signal transduction|neutrophil activation|positive regulation of apoptotic process|dendritic shaft|positive regulation of GTPase activity|perinuclear region of cytoplasm|regulation of dendrite development|regulation of small GTPase mediated signal transduction|positive regulation of substrate adhesion-dependent cell spreading "hsa04062,hsa05167" Chemokine signaling pathway|Kaposi sarcoma-associated herpesvirus infection PRH1 13.53860204 16.23929549 10.83790858 0.667387855 -0.583402663 0.677251882 1 0.710244411 0.494426857 5554 proline rich protein HaeIII subfamily 1 "GO:0005515,GO:0005615" protein binding|extracellular space hsa04970 Salivary secretion PRH1-TAS2R14 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.121092908 0 106707243 PRH1-TAS2R14 readthrough PRICKLE1 111.0419229 114.6900244 107.3938214 0.936383281 -0.094828919 0.898191841 1 0.84661786 0.826907644 144165 prickle planar cell polarity protein 1 "GO:0001843,GO:0005515,GO:0005634,GO:0005829,GO:0006606,GO:0008270,GO:0031398,GO:0031965,GO:0032436,GO:0035904,GO:0045892,GO:0060071,GO:0060976,GO:0090090,GO:2000691" "neural tube closure|protein binding|nucleus|cytosol|protein import into nucleus|zinc ion binding|positive regulation of protein ubiquitination|nuclear membrane|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|aorta development|negative regulation of transcription, DNA-templated|Wnt signaling pathway, planar cell polarity pathway|coronary vasculature development|negative regulation of canonical Wnt signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation" hsa04310 Wnt signaling pathway PRICKLE2 126.2811082 146.1536594 106.408557 0.728059478 -0.457871781 0.468464703 1 0.327037521 0.248359268 166336 prickle planar cell polarity protein 2 "GO:0005737,GO:0008270,GO:0031965,GO:0060071" "cytoplasm|zinc ion binding|nuclear membrane|Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway PRICKLE3 622.006435 660.7363354 583.2765346 0.882767457 -0.179894649 0.644721189 1 11.68842628 10.76262693 4007 prickle planar cell polarity protein 3 "GO:0005515,GO:0005737,GO:0005886,GO:0007275,GO:0008150,GO:0008270,GO:0030030" protein binding|cytoplasm|plasma membrane|multicellular organism development|biological_process|zinc ion binding|cell projection organization hsa04310 Wnt signaling pathway PRICKLE4 270.4805684 237.4996966 303.4614403 1.277734012 0.35358754 0.471276145 1 7.050716169 9.397008454 29964 prickle planar cell polarity protein 4 "GO:0001725,GO:0003674,GO:0003779,GO:0005634,GO:0005912,GO:0007507,GO:0008150,GO:0008270,GO:0030018,GO:0030036,GO:0031941,GO:0051371,GO:0061061" stress fiber|molecular_function|actin binding|nucleus|adherens junction|heart development|biological_process|zinc ion binding|Z disc|actin cytoskeleton organization|filamentous actin|muscle alpha-actinin binding|muscle structure development hsa04310 Wnt signaling pathway PRIM1 593.2489366 547.061267 639.4366063 1.168857393 0.225098924 0.567406827 1 19.47064178 23.73874332 5557 DNA primase subunit 1 "GO:0000082,GO:0003896,GO:0005515,GO:0005654,GO:0005658,GO:0006269,GO:0006270,GO:0016020,GO:0032201,GO:0046872" "G1/S transition of mitotic cell cycle|DNA primase activity|protein binding|nucleoplasm|alpha DNA polymerase:primase complex|DNA replication, synthesis of RNA primer|DNA replication initiation|membrane|telomere maintenance via semi-conservative replication|metal ion binding" hsa03030 DNA replication PRIM2 349.0923971 425.2665507 272.9182434 0.641758076 -0.639898549 0.156510246 1 3.165062534 2.118700492 5558 DNA primase subunit 2 "GO:0000082,GO:0003677,GO:0005515,GO:0005654,GO:0005658,GO:0006269,GO:0006270,GO:0032201,GO:0046872,GO:0051539" "G1/S transition of mitotic cell cycle|DNA binding|protein binding|nucleoplasm|alpha DNA polymerase:primase complex|DNA replication, synthesis of RNA primer|DNA replication initiation|telomere maintenance via semi-conservative replication|metal ion binding|4 iron, 4 sulfur cluster binding" hsa03030 DNA replication PRIMPOL 266.3289483 256.78386 275.8740366 1.074343367 0.103455161 0.839816872 1 5.038820856 5.646612103 201973 primase and DNA directed polymerase "GO:0003682,GO:0003887,GO:0003896,GO:0005515,GO:0005634,GO:0005657,GO:0005759,GO:0006264,GO:0006269,GO:0008270,GO:0009411,GO:0019985,GO:0030145,GO:0031297,GO:0042276,GO:0043504,GO:0062176" "chromatin binding|DNA-directed DNA polymerase activity|DNA primase activity|protein binding|nucleus|replication fork|mitochondrial matrix|mitochondrial DNA replication|DNA replication, synthesis of RNA primer|zinc ion binding|response to UV|translesion synthesis|manganese ion binding|replication fork processing|error-prone translesion synthesis|mitochondrial DNA repair|R-loop disassembly" PRKAA1 2070.290203 2071.525131 2069.055275 0.998807711 -0.001721136 0.997450439 1 15.59617066 16.24859429 5562 protein kinase AMP-activated catalytic subunit alpha 1 "GO:0000187,GO:0001666,GO:0003682,GO:0004672,GO:0004674,GO:0004679,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006006,GO:0006468,GO:0006633,GO:0006695,GO:0007050,GO:0007165,GO:0008022,GO:0008284,GO:0008610,GO:0009411,GO:0009631,GO:0010332,GO:0010508,GO:0010628,GO:0010629,GO:0014823,GO:0015721,GO:0016055,GO:0016236,GO:0016241,GO:0016324,GO:0016607,GO:0019395,GO:0030424,GO:0030425,GO:0031000,GO:0031588,GO:0031669,GO:0032007,GO:0033135,GO:0034599,GO:0035174,GO:0035404,GO:0035556,GO:0035690,GO:0038183,GO:0042149,GO:0042593,GO:0042752,GO:0043025,GO:0043066,GO:0044877,GO:0045542,GO:0045821,GO:0046318,GO:0046627,GO:0046872,GO:0047322,GO:0048156,GO:0048511,GO:0048643,GO:0050321,GO:0050405,GO:0050995,GO:0055089,GO:0060627,GO:0061744,GO:0061762,GO:0062028,GO:0070050,GO:0070301,GO:0070507,GO:0071277,GO:0071333,GO:0071361,GO:0071380,GO:0071417,GO:0071456,GO:0097009,GO:0106310,GO:0106311,GO:0120188,GO:1901563,GO:1901796,GO:1903109,GO:1903829,GO:1903955,GO:1904428,GO:1904486,GO:2000758" activation of MAPK activity|response to hypoxia|chromatin binding|protein kinase activity|protein serine/threonine kinase activity|AMP-activated protein kinase activity|cAMP-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|glucose metabolic process|protein phosphorylation|fatty acid biosynthetic process|cholesterol biosynthetic process|cell cycle arrest|signal transduction|protein C-terminus binding|positive regulation of cell population proliferation|lipid biosynthetic process|response to UV|cold acclimation|response to gamma radiation|positive regulation of autophagy|positive regulation of gene expression|negative regulation of gene expression|response to activity|bile acid and bile salt transport|Wnt signaling pathway|macroautophagy|regulation of macroautophagy|apical plasma membrane|nuclear speck|fatty acid oxidation|axon|dendrite|response to caffeine|nucleotide-activated protein kinase complex|cellular response to nutrient levels|negative regulation of TOR signaling|regulation of peptidyl-serine phosphorylation|cellular response to oxidative stress|histone serine kinase activity|histone-serine phosphorylation|intracellular signal transduction|cellular response to drug|bile acid signaling pathway|cellular response to glucose starvation|glucose homeostasis|regulation of circadian rhythm|neuronal cell body|negative regulation of apoptotic process|protein-containing complex binding|positive regulation of cholesterol biosynthetic process|positive regulation of glycolytic process|negative regulation of glucosylceramide biosynthetic process|negative regulation of insulin receptor signaling pathway|metal ion binding|[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity|tau protein binding|rhythmic process|positive regulation of skeletal muscle tissue development|tau-protein kinase activity|[acetyl-CoA carboxylase] kinase activity|negative regulation of lipid catabolic process|fatty acid homeostasis|regulation of vesicle-mediated transport|motor behavior|CAMKK-AMPK signaling cascade|regulation of stress granule assembly|neuron cellular homeostasis|cellular response to hydrogen peroxide|regulation of microtubule cytoskeleton organization|cellular response to calcium ion|cellular response to glucose stimulus|cellular response to ethanol|cellular response to prostaglandin E stimulus|cellular response to organonitrogen compound|cellular response to hypoxia|energy homeostasis|protein serine kinase activity|protein threonine kinase activity|regulation of bile acid secretion|response to camptothecin|regulation of signal transduction by p53 class mediator|positive regulation of mitochondrial transcription|positive regulation of cellular protein localization|positive regulation of protein targeting to mitochondrion|negative regulation of tubulin deacetylation|response to 17alpha-ethynylestradiol|positive regulation of peptidyl-lysine acetylation "hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410,hsa05418" FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy|Fluid shear stress and atherosclerosis PRKAA2 435.4636154 469.9246134 401.0026175 0.853333931 -0.22881768 0.591293997 1 2.101732945 1.870735882 5563 protein kinase AMP-activated catalytic subunit alpha 2 "GO:0003682,GO:0004672,GO:0004674,GO:0004679,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006468,GO:0006633,GO:0006695,GO:0006853,GO:0007050,GO:0007165,GO:0008610,GO:0010494,GO:0010508,GO:0010629,GO:0014850,GO:0016055,GO:0016236,GO:0016239,GO:0016241,GO:0016607,GO:0030424,GO:0030425,GO:0031669,GO:0032007,GO:0034599,GO:0035174,GO:0035404,GO:0035556,GO:0035690,GO:0042149,GO:0042304,GO:0042593,GO:0042752,GO:0043025,GO:0043066,GO:0045821,GO:0046872,GO:0047322,GO:0048511,GO:0050405,GO:0055089,GO:0062028,GO:0070507,GO:0071277,GO:0071333,GO:0071380,GO:0097009,GO:0106310,GO:0106311,GO:1901796,GO:1903829,GO:1904428,GO:2000758" chromatin binding|protein kinase activity|protein serine/threonine kinase activity|AMP-activated protein kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|protein phosphorylation|fatty acid biosynthetic process|cholesterol biosynthetic process|carnitine shuttle|cell cycle arrest|signal transduction|lipid biosynthetic process|cytoplasmic stress granule|positive regulation of autophagy|negative regulation of gene expression|response to muscle activity|Wnt signaling pathway|macroautophagy|positive regulation of macroautophagy|regulation of macroautophagy|nuclear speck|axon|dendrite|cellular response to nutrient levels|negative regulation of TOR signaling|cellular response to oxidative stress|histone serine kinase activity|histone-serine phosphorylation|intracellular signal transduction|cellular response to drug|cellular response to glucose starvation|regulation of fatty acid biosynthetic process|glucose homeostasis|regulation of circadian rhythm|neuronal cell body|negative regulation of apoptotic process|positive regulation of glycolytic process|metal ion binding|[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity|rhythmic process|[acetyl-CoA carboxylase] kinase activity|fatty acid homeostasis|regulation of stress granule assembly|regulation of microtubule cytoskeleton organization|cellular response to calcium ion|cellular response to glucose stimulus|cellular response to prostaglandin E stimulus|energy homeostasis|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|positive regulation of cellular protein localization|negative regulation of tubulin deacetylation|positive regulation of peptidyl-lysine acetylation "hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410,hsa05418" FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy|Fluid shear stress and atherosclerosis PRKAB1 869.8313651 831.2489381 908.4137921 1.092830018 0.128069018 0.725090002 1 17.53428832 19.98741772 5564 protein kinase AMP-activated non-catalytic subunit beta 1 "GO:0004672,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006633,GO:0007050,GO:0007165,GO:0010628,GO:0016236,GO:0016241,GO:0019901,GO:0031588,GO:0035878,GO:0050790,GO:0120162,GO:1901796" protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|fatty acid biosynthetic process|cell cycle arrest|signal transduction|positive regulation of gene expression|macroautophagy|regulation of macroautophagy|protein kinase binding|nucleotide-activated protein kinase complex|nail development|regulation of catalytic activity|positive regulation of cold-induced thermogenesis|regulation of signal transduction by p53 class mediator "hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410" FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy PRKAB2 601.6506541 582.5847258 620.7165824 1.065452894 0.09146681 0.818396538 1 5.484360805 6.095034969 5565 protein kinase AMP-activated non-catalytic subunit beta 2 "GO:0004679,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006633,GO:0006853,GO:0007050,GO:0007165,GO:0016236,GO:0016241,GO:0019901,GO:0031588,GO:0042304,GO:0042802,GO:0050790,GO:0120162,GO:1901796" AMP-activated protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|fatty acid biosynthetic process|carnitine shuttle|cell cycle arrest|signal transduction|macroautophagy|regulation of macroautophagy|protein kinase binding|nucleotide-activated protein kinase complex|regulation of fatty acid biosynthetic process|identical protein binding|regulation of catalytic activity|positive regulation of cold-induced thermogenesis|regulation of signal transduction by p53 class mediator "hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410" FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy PRKACA 1962.598228 1882.743321 2042.453136 1.084828246 0.117466648 0.716738924 1 29.12471207 32.95630814 5566 protein kinase cAMP-activated catalytic subunit alpha "GO:0000086,GO:0000287,GO:0001669,GO:0001707,GO:0001843,GO:0002027,GO:0002223,GO:0003091,GO:0004672,GO:0004674,GO:0004679,GO:0004691,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005930,GO:0005952,GO:0006397,GO:0006468,GO:0007596,GO:0010389,GO:0010737,GO:0010881,GO:0016020,GO:0016241,GO:0016607,GO:0018105,GO:0018107,GO:0019221,GO:0019901,GO:0019904,GO:0030145,GO:0031594,GO:0031625,GO:0034199,GO:0034237,GO:0034380,GO:0034605,GO:0034704,GO:0035584,GO:0036126,GO:0043197,GO:0043393,GO:0044853,GO:0045667,GO:0046777,GO:0046827,GO:0048240,GO:0048471,GO:0050804,GO:0051480,GO:0055117,GO:0060314,GO:0061136,GO:0070062,GO:0070613,GO:0071158,GO:0071333,GO:0071374,GO:0071377,GO:0071872,GO:0086064,GO:0097546,GO:0097711,GO:1901621,GO:1903779,GO:2000810" G2/M transition of mitotic cell cycle|magnesium ion binding|acrosomal vesicle|mesoderm formation|neural tube closure|regulation of heart rate|stimulatory C-type lectin receptor signaling pathway|renal water homeostasis|protein kinase activity|protein serine/threonine kinase activity|AMP-activated protein kinase activity|cAMP-dependent protein kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|centrosome|cytosol|axoneme|cAMP-dependent protein kinase complex|mRNA processing|protein phosphorylation|blood coagulation|regulation of G2/M transition of mitotic cell cycle|protein kinase A signaling|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|membrane|regulation of macroautophagy|nuclear speck|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cytokine-mediated signaling pathway|protein kinase binding|protein domain specific binding|manganese ion binding|neuromuscular junction|ubiquitin protein ligase binding|activation of protein kinase A activity|protein kinase A regulatory subunit binding|high-density lipoprotein particle assembly|cellular response to heat|calcium channel complex|calcium-mediated signaling using intracellular calcium source|sperm flagellum|dendritic spine|regulation of protein binding|plasma membrane raft|regulation of osteoblast differentiation|protein autophosphorylation|positive regulation of protein export from nucleus|sperm capacitation|perinuclear region of cytoplasm|modulation of chemical synaptic transmission|regulation of cytosolic calcium ion concentration|regulation of cardiac muscle contraction|regulation of ryanodine-sensitive calcium-release channel activity|regulation of proteasomal protein catabolic process|extracellular exosome|regulation of protein processing|positive regulation of cell cycle arrest|cellular response to glucose stimulus|cellular response to parathyroid hormone stimulus|cellular response to glucagon stimulus|cellular response to epinephrine stimulus|cell communication by electrical coupling involved in cardiac conduction|ciliary base|ciliary basal body-plasma membrane docking|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|regulation of cardiac conduction|regulation of bicellular tight junction assembly "hsa01522,hsa04010,hsa04014,hsa04020,hsa04024,hsa04062,hsa04114,hsa04140,hsa04211,hsa04213,hsa04261,hsa04270,hsa04310,hsa04340,hsa04371,hsa04530,hsa04540,hsa04611,hsa04713,hsa04714,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04742,hsa04750,hsa04910,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04961,hsa04962,hsa04970,hsa04971,hsa04976,hsa05012,hsa05020,hsa05030,hsa05031,hsa05032,hsa05034,hsa05110,hsa05146,hsa05163,hsa05165,hsa05166,hsa05200,hsa05203,hsa05205,hsa05414" "Endocrine resistance|MAPK signaling pathway|Ras signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Oocyte meiosis|Autophagy - animal|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Hedgehog signaling pathway|Apelin signaling pathway|Tight junction|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Bile secretion|Parkinson disease|Prion disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Vibrio cholerae infection|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Dilated cardiomyopathy" PRKACB 996.3230358 958.1184341 1034.527637 1.079749226 0.110696282 0.755515806 1 7.30913069 8.231984771 5567 protein kinase cAMP-activated catalytic subunit beta "GO:0000287,GO:0001843,GO:0002223,GO:0003091,GO:0004679,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0005886,GO:0005952,GO:0006468,GO:0007165,GO:0007188,GO:0007596,GO:0010737,GO:0031625,GO:0034199,GO:0034380,GO:0048471,GO:0051447,GO:0070062,GO:0070613,GO:0071377,GO:0097338,GO:0097546,GO:1901621" magnesium ion binding|neural tube closure|stimulatory C-type lectin receptor signaling pathway|renal water homeostasis|AMP-activated protein kinase activity|cAMP-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|centrosome|cytosol|plasma membrane|cAMP-dependent protein kinase complex|protein phosphorylation|signal transduction|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|blood coagulation|protein kinase A signaling|ubiquitin protein ligase binding|activation of protein kinase A activity|high-density lipoprotein particle assembly|perinuclear region of cytoplasm|negative regulation of meiotic cell cycle|extracellular exosome|regulation of protein processing|cellular response to glucagon stimulus|response to clozapine|ciliary base|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning "hsa01522,hsa04010,hsa04014,hsa04020,hsa04024,hsa04062,hsa04114,hsa04140,hsa04211,hsa04213,hsa04261,hsa04270,hsa04310,hsa04340,hsa04371,hsa04530,hsa04540,hsa04611,hsa04713,hsa04714,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04742,hsa04750,hsa04910,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04961,hsa04962,hsa04970,hsa04971,hsa04976,hsa05012,hsa05020,hsa05030,hsa05031,hsa05032,hsa05034,hsa05110,hsa05146,hsa05163,hsa05165,hsa05166,hsa05200,hsa05203,hsa05205,hsa05414" "Endocrine resistance|MAPK signaling pathway|Ras signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Oocyte meiosis|Autophagy - animal|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Hedgehog signaling pathway|Apelin signaling pathway|Tight junction|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Bile secretion|Parkinson disease|Prion disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Vibrio cholerae infection|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Dilated cardiomyopathy" PRKAG1 2020.910938 2029.911937 2011.909939 0.991131636 -0.012851415 0.969840865 1 45.30977457 46.84240339 5571 protein kinase AMP-activated non-catalytic subunit gamma 1 "GO:0004672,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006110,GO:0006468,GO:0006633,GO:0007050,GO:0007165,GO:0007283,GO:0008603,GO:0010628,GO:0016020,GO:0016208,GO:0016236,GO:0016241,GO:0019887,GO:0019901,GO:0031588,GO:0042149,GO:0043531,GO:0045860,GO:0050790,GO:0051170,GO:1901796,GO:2000479" protein kinase activity|cAMP-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of glycolytic process|protein phosphorylation|fatty acid biosynthetic process|cell cycle arrest|signal transduction|spermatogenesis|cAMP-dependent protein kinase regulator activity|positive regulation of gene expression|membrane|AMP binding|macroautophagy|regulation of macroautophagy|protein kinase regulator activity|protein kinase binding|nucleotide-activated protein kinase complex|cellular response to glucose starvation|ADP binding|positive regulation of protein kinase activity|regulation of catalytic activity|import into nucleus|regulation of signal transduction by p53 class mediator|regulation of cAMP-dependent protein kinase activity "hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410" FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy PRKAG2 989.0426702 1268.69496 709.3903799 0.559149679 -0.838693564 0.018007468 0.579832117 7.575444949 4.418269025 51422 protein kinase AMP-activated non-catalytic subunit gamma 2 "GO:0004862,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005977,GO:0006110,GO:0006468,GO:0006469,GO:0006633,GO:0006754,GO:0006853,GO:0007050,GO:0008603,GO:0008607,GO:0010800,GO:0016126,GO:0016208,GO:0016236,GO:0016241,GO:0019217,GO:0019887,GO:0019901,GO:0030295,GO:0031588,GO:0032147,GO:0035556,GO:0042149,GO:0042304,GO:0043531,GO:0045860,GO:0046320,GO:0046324,GO:0050790,GO:1901796,GO:2000480" cAMP-dependent protein kinase inhibitor activity|protein binding|ATP binding|extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|glycogen metabolic process|regulation of glycolytic process|protein phosphorylation|negative regulation of protein kinase activity|fatty acid biosynthetic process|ATP biosynthetic process|carnitine shuttle|cell cycle arrest|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|positive regulation of peptidyl-threonine phosphorylation|sterol biosynthetic process|AMP binding|macroautophagy|regulation of macroautophagy|regulation of fatty acid metabolic process|protein kinase regulator activity|protein kinase binding|protein kinase activator activity|nucleotide-activated protein kinase complex|activation of protein kinase activity|intracellular signal transduction|cellular response to glucose starvation|regulation of fatty acid biosynthetic process|ADP binding|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glucose import|regulation of catalytic activity|regulation of signal transduction by p53 class mediator|negative regulation of cAMP-dependent protein kinase activity "hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410" FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy PRKAR1A 7753.463381 7168.634005 8338.292757 1.163163408 0.218053789 0.508631279 1 81.80847745 99.25558899 5573 protein kinase cAMP-dependent type I regulatory subunit alpha "GO:0001707,GO:0001772,GO:0003091,GO:0004862,GO:0005515,GO:0005737,GO:0005771,GO:0005813,GO:0005829,GO:0005930,GO:0005952,GO:0006357,GO:0007143,GO:0007596,GO:0008603,GO:0010738,GO:0016020,GO:0019904,GO:0030552,GO:0031588,GO:0031594,GO:0031625,GO:0032991,GO:0034199,GO:0034236,GO:0035556,GO:0043949,GO:0044853,GO:0045214,GO:0045835,GO:0046007,GO:0060038,GO:0071377,GO:0097224,GO:0097546,GO:0098978,GO:2000480" mesoderm formation|immunological synapse|renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|protein binding|cytoplasm|multivesicular body|centrosome|cytosol|axoneme|cAMP-dependent protein kinase complex|regulation of transcription by RNA polymerase II|female meiotic nuclear division|blood coagulation|cAMP-dependent protein kinase regulator activity|regulation of protein kinase A signaling|membrane|protein domain specific binding|cAMP binding|nucleotide-activated protein kinase complex|neuromuscular junction|ubiquitin protein ligase binding|protein-containing complex|activation of protein kinase A activity|protein kinase A catalytic subunit binding|intracellular signal transduction|regulation of cAMP-mediated signaling|plasma membrane raft|sarcomere organization|negative regulation of meiotic nuclear division|negative regulation of activated T cell proliferation|cardiac muscle cell proliferation|cellular response to glucagon stimulus|sperm connecting piece|ciliary base|glutamatergic synapse|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKAR1B 668.2084583 855.6078813 480.8090353 0.561950218 -0.831485765 0.029889786 0.770201835 13.22757045 7.753429759 5575 protein kinase cAMP-dependent type I regulatory subunit beta "GO:0003091,GO:0004862,GO:0005515,GO:0005771,GO:0005829,GO:0005886,GO:0005952,GO:0006468,GO:0007596,GO:0007611,GO:0008603,GO:0010738,GO:0030552,GO:0034199,GO:0034236,GO:0043949,GO:0050804,GO:0071377,GO:0097546,GO:0098685,GO:0098686,GO:0098693,GO:0098978,GO:2000480" renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|protein binding|multivesicular body|cytosol|plasma membrane|cAMP-dependent protein kinase complex|protein phosphorylation|blood coagulation|learning or memory|cAMP-dependent protein kinase regulator activity|regulation of protein kinase A signaling|cAMP binding|activation of protein kinase A activity|protein kinase A catalytic subunit binding|regulation of cAMP-mediated signaling|modulation of chemical synaptic transmission|cellular response to glucagon stimulus|ciliary base|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|regulation of synaptic vesicle cycle|glutamatergic synapse|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKAR2A 1790.008209 1938.5659 1641.450518 0.846734443 -0.240018519 0.460738979 1 14.1065408 12.45901433 5576 protein kinase cAMP-dependent type II regulatory subunit alpha "GO:0003091,GO:0004862,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005925,GO:0005930,GO:0005952,GO:0007596,GO:0008603,GO:0010738,GO:0016020,GO:0019904,GO:0030552,GO:0031588,GO:0031625,GO:0032991,GO:0034199,GO:0034236,GO:0035556,GO:0043949,GO:0044853,GO:0070062,GO:0071377,GO:0097546,GO:2000480" renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|protein binding|cytoplasm|centrosome|cytosol|plasma membrane|focal adhesion|axoneme|cAMP-dependent protein kinase complex|blood coagulation|cAMP-dependent protein kinase regulator activity|regulation of protein kinase A signaling|membrane|protein domain specific binding|cAMP binding|nucleotide-activated protein kinase complex|ubiquitin protein ligase binding|protein-containing complex|activation of protein kinase A activity|protein kinase A catalytic subunit binding|intracellular signal transduction|regulation of cAMP-mediated signaling|plasma membrane raft|extracellular exosome|cellular response to glucagon stimulus|ciliary base|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKAR2B 310.3310752 334.9354696 285.7266808 0.853079792 -0.229247405 0.627474036 1 4.188469124 3.727012957 5577 protein kinase cAMP-dependent type II regulatory subunit beta "GO:0000086,GO:0003091,GO:0004862,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005952,GO:0006631,GO:0007596,GO:0007612,GO:0008603,GO:0010389,GO:0010738,GO:0019904,GO:0030552,GO:0031625,GO:0034199,GO:0034236,GO:0035556,GO:0043025,GO:0043197,GO:0043198,GO:0043949,GO:0045121,GO:0048471,GO:0050804,GO:0070062,GO:0071377,GO:0097332,GO:0097338,GO:0097546,GO:0097711,GO:0098978,GO:2000480" G2/M transition of mitotic cell cycle|renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|protein binding|cytoplasm|centrosome|cytosol|plasma membrane|cAMP-dependent protein kinase complex|fatty acid metabolic process|blood coagulation|learning|cAMP-dependent protein kinase regulator activity|regulation of G2/M transition of mitotic cell cycle|regulation of protein kinase A signaling|protein domain specific binding|cAMP binding|ubiquitin protein ligase binding|activation of protein kinase A activity|protein kinase A catalytic subunit binding|intracellular signal transduction|neuronal cell body|dendritic spine|dendritic shaft|regulation of cAMP-mediated signaling|membrane raft|perinuclear region of cytoplasm|modulation of chemical synaptic transmission|extracellular exosome|cellular response to glucagon stimulus|response to antipsychotic drug|response to clozapine|ciliary base|ciliary basal body-plasma membrane docking|glutamatergic synapse|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKCA 1185.285717 1314.367979 1056.203455 0.803582765 -0.315481473 0.357469048 1 5.362341012 4.494702714 5578 protein kinase C alpha "GO:0001525,GO:0001938,GO:0002159,GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0005178,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0006468,GO:0007077,GO:0007155,GO:0007411,GO:0008270,GO:0010595,GO:0010613,GO:0018105,GO:0018107,GO:0019899,GO:0030168,GO:0030335,GO:0031666,GO:0031966,GO:0034351,GO:0035403,GO:0035408,GO:0035556,GO:0035866,GO:0038128,GO:0043488,GO:0043536,GO:0045651,GO:0045766,GO:0045780,GO:0045785,GO:0045931,GO:0048471,GO:0050796,GO:0070062,GO:0070374,GO:0070555,GO:0090330,GO:0097190,GO:0106071,GO:2000707" angiogenesis|positive regulation of endothelial cell proliferation|desmosome assembly|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|integrin binding|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|protein phosphorylation|mitotic nuclear envelope disassembly|cell adhesion|axon guidance|zinc ion binding|positive regulation of endothelial cell migration|positive regulation of cardiac muscle hypertrophy|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|enzyme binding|platelet activation|positive regulation of cell migration|positive regulation of lipopolysaccharide-mediated signaling pathway|mitochondrial membrane|negative regulation of glial cell apoptotic process|histone kinase activity (H3-T6 specific)|histone H3-T6 phosphorylation|intracellular signal transduction|alphav-beta3 integrin-PKCalpha complex|ERBB2 signaling pathway|regulation of mRNA stability|positive regulation of blood vessel endothelial cell migration|positive regulation of macrophage differentiation|positive regulation of angiogenesis|positive regulation of bone resorption|positive regulation of cell adhesion|positive regulation of mitotic cell cycle|perinuclear region of cytoplasm|regulation of insulin secretion|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|regulation of platelet aggregation|apoptotic signaling pathway|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of dense core granule biogenesis "hsa01521,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04070,hsa04071,hsa04072,hsa04150,hsa04151,hsa04261,hsa04270,hsa04310,hsa04360,hsa04370,hsa04510,hsa04540,hsa04650,hsa04664,hsa04666,hsa04670,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04916,hsa04918,hsa04919,hsa04921,hsa04925,hsa04926,hsa04928,hsa04929,hsa04933,hsa04935,hsa04960,hsa04961,hsa04970,hsa04971,hsa04972,hsa05017,hsa05022,hsa05031,hsa05032,hsa05110,hsa05143,hsa05146,hsa05161,hsa05163,hsa05164,hsa05170,hsa05171,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225,hsa05231" "EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Gap junction|Natural killer cell mediated cytotoxicity|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Morphine addiction|Vibrio cholerae infection|African trypanosomiasis|Amoebiasis|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma|Choline metabolism in cancer" PRKCD 1219.47454 1092.092622 1346.856457 1.233280429 0.302500884 0.375562634 1 17.68808399 22.7540423 5580 protein kinase C delta "GO:0002223,GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0004699,GO:0004715,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0006915,GO:0007049,GO:0007165,GO:0008047,GO:0008631,GO:0010469,GO:0016064,GO:0016363,GO:0016572,GO:0018105,GO:0018107,GO:0018108,GO:0019899,GO:0019900,GO:0019901,GO:0023021,GO:0030168,GO:0030837,GO:0032079,GO:0032091,GO:0032147,GO:0032930,GO:0032956,GO:0034351,GO:0034644,GO:0035307,GO:0035556,GO:0035578,GO:0036019,GO:0038096,GO:0042100,GO:0042119,GO:0042307,GO:0042742,GO:0043312,GO:0043407,GO:0043488,GO:0043560,GO:0046627,GO:0046872,GO:0048471,GO:0050728,GO:0050732,GO:0050821,GO:0051490,GO:0060326,GO:0060333,GO:0070062,GO:0070301,GO:0071447,GO:0090331,GO:0090398,GO:0106310,GO:1900163,GO:1904385,GO:2000303,GO:2000304,GO:2000753,GO:2000755,GO:2001022,GO:2001235" stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|calcium-independent protein kinase C activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|cell-cell junction|protein phosphorylation|apoptotic process|cell cycle|signal transduction|enzyme activator activity|intrinsic apoptotic signaling pathway in response to oxidative stress|regulation of signaling receptor activity|immunoglobulin mediated immune response|nuclear matrix|histone phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|enzyme binding|kinase binding|protein kinase binding|termination of signal transduction|platelet activation|negative regulation of actin filament polymerization|positive regulation of endodeoxyribonuclease activity|negative regulation of protein binding|activation of protein kinase activity|positive regulation of superoxide anion generation|regulation of actin cytoskeleton organization|negative regulation of glial cell apoptotic process|cellular response to UV|positive regulation of protein dephosphorylation|intracellular signal transduction|azurophil granule lumen|endolysosome|Fc-gamma receptor signaling pathway involved in phagocytosis|B cell proliferation|neutrophil activation|positive regulation of protein import into nucleus|defense response to bacterium|neutrophil degranulation|negative regulation of MAP kinase activity|regulation of mRNA stability|insulin receptor substrate binding|negative regulation of insulin receptor signaling pathway|metal ion binding|perinuclear region of cytoplasm|negative regulation of inflammatory response|negative regulation of peptidyl-tyrosine phosphorylation|protein stabilization|negative regulation of filopodium assembly|cell chemotaxis|interferon-gamma-mediated signaling pathway|extracellular exosome|cellular response to hydrogen peroxide|cellular response to hydroperoxide|negative regulation of platelet aggregation|cellular senescence|protein serine kinase activity|positive regulation of phospholipid scramblase activity|cellular response to angiotensin|regulation of ceramide biosynthetic process|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of sphingomyelin catabolic process|positive regulation of response to DNA damage stimulus|positive regulation of apoptotic signaling pathway "hsa04062,hsa04140,hsa04270,hsa04621,hsa04625,hsa04666,hsa04722,hsa04750,hsa04912,hsa04915,hsa04930,hsa04931,hsa04933,hsa05020,hsa05131" Chemokine signaling pathway|Autophagy - animal|Vascular smooth muscle contraction|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Fc gamma R-mediated phagocytosis|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Estrogen signaling pathway|Type II diabetes mellitus|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Prion disease|Shigellosis PRKCE 176.452643 174.5724266 178.3328594 1.021540818 0.030746851 0.967399947 1 0.343158453 0.365650655 5581 protein kinase C epsilon "GO:0002281,GO:0003785,GO:0004674,GO:0004697,GO:0004698,GO:0004699,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0007049,GO:0007155,GO:0007165,GO:0008047,GO:0010634,GO:0010763,GO:0010811,GO:0018105,GO:0019899,GO:0030168,GO:0030546,GO:0030838,GO:0031397,GO:0031663,GO:0032024,GO:0032230,GO:0032467,GO:0035276,GO:0035556,GO:0035641,GO:0035669,GO:0038096,GO:0043123,GO:0043231,GO:0043278,GO:0043410,GO:0045111,GO:0046872,GO:0048471,GO:0050730,GO:0050790,GO:0050996,GO:0051279,GO:0051301,GO:0061178,GO:0070257,GO:0071361,GO:0071380,GO:0071456,GO:0071889,GO:0071944,GO:0090303,GO:1903078,GO:2000650,GO:2001031" "macrophage activation involved in immune response|actin monomer binding|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|calcium-independent protein kinase C activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|protein phosphorylation|apoptotic process|cell cycle|cell adhesion|signal transduction|enzyme activator activity|positive regulation of epithelial cell migration|positive regulation of fibroblast migration|positive regulation of cell-substrate adhesion|peptidyl-serine phosphorylation|enzyme binding|platelet activation|signaling receptor activator activity|positive regulation of actin filament polymerization|negative regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|positive regulation of insulin secretion|positive regulation of synaptic transmission, GABAergic|positive regulation of cytokinesis|ethanol binding|intracellular signal transduction|locomotory exploration behavior|TRAM-dependent toll-like receptor 4 signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|response to morphine|positive regulation of MAPK cascade|intermediate filament cytoskeleton|metal ion binding|perinuclear region of cytoplasm|regulation of peptidyl-tyrosine phosphorylation|regulation of catalytic activity|positive regulation of lipid catabolic process|regulation of release of sequestered calcium ion into cytosol|cell division|regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of mucus secretion|cellular response to ethanol|cellular response to prostaglandin E stimulus|cellular response to hypoxia|14-3-3 protein binding|cell periphery|positive regulation of wound healing|positive regulation of protein localization to plasma membrane|negative regulation of sodium ion transmembrane transporter activity|positive regulation of cellular glucuronidation" "hsa04022,hsa04071,hsa04270,hsa04371,hsa04530,hsa04666,hsa04750,hsa04925,hsa04930,hsa04931,hsa04933,hsa05131,hsa05206" cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Tight junction|Fc gamma R-mediated phagocytosis|Inflammatory mediator regulation of TRP channels|Aldosterone synthesis and secretion|Type II diabetes mellitus|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Shigellosis|MicroRNAs in cancer PRKCG 11.59776476 18.26920743 4.926322083 0.269651658 -1.890831188 0.166958408 1 0.303666198 0.085411329 5582 protein kinase C gamma "GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0007268,GO:0007611,GO:0007635,GO:0008270,GO:0014069,GO:0016310,GO:0018105,GO:0030168,GO:0030425,GO:0031397,GO:0032095,GO:0032425,GO:0035556,GO:0042177,GO:0042752,GO:0043278,GO:0043524,GO:0044305,GO:0046777,GO:0048265,GO:0048471,GO:0048511,GO:0050764,GO:0060384,GO:0097060,GO:0099171,GO:0099523,GO:0099524,GO:1901799,GO:1990911,GO:2000300" protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|cytosol|plasma membrane|cell-cell junction|protein phosphorylation|chemical synaptic transmission|learning or memory|chemosensory behavior|zinc ion binding|postsynaptic density|phosphorylation|peptidyl-serine phosphorylation|platelet activation|dendrite|negative regulation of protein ubiquitination|regulation of response to food|positive regulation of mismatch repair|intracellular signal transduction|negative regulation of protein catabolic process|regulation of circadian rhythm|response to morphine|negative regulation of neuron apoptotic process|calyx of Held|protein autophosphorylation|response to pain|perinuclear region of cytoplasm|rhythmic process|regulation of phagocytosis|innervation|synaptic membrane|presynaptic modulation of chemical synaptic transmission|presynaptic cytosol|postsynaptic cytosol|negative regulation of proteasomal protein catabolic process|response to psychosocial stress|regulation of synaptic vesicle exocytosis "hsa01521,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04070,hsa04071,hsa04150,hsa04270,hsa04310,hsa04370,hsa04510,hsa04540,hsa04650,hsa04666,hsa04670,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04750,hsa04911,hsa04916,hsa04918,hsa04919,hsa04921,hsa04925,hsa04928,hsa04929,hsa04935,hsa04960,hsa04961,hsa04970,hsa04971,hsa04972,hsa05017,hsa05022,hsa05031,hsa05032,hsa05143,hsa05146,hsa05161,hsa05163,hsa05170,hsa05171,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225,hsa05231" "EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|mTOR signaling pathway|Vascular smooth muscle contraction|Wnt signaling pathway|VEGF signaling pathway|Focal adhesion|Gap junction|Natural killer cell mediated cytotoxicity|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Morphine addiction|African trypanosomiasis|Amoebiasis|Hepatitis B|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma|Choline metabolism in cancer" PRKCH 161.8666718 187.7668541 135.9664895 0.724124021 -0.465691285 0.422137866 1 1.097614123 0.82904589 5583 protein kinase C eta "GO:0004674,GO:0004697,GO:0004698,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0010744,GO:0018105,GO:0019899,GO:0030168,GO:0034351,GO:0035556,GO:0045618,GO:0046872,GO:0050861,GO:0051092,GO:0060252,GO:0070062,GO:1903078,GO:2000810" protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|signal transduction|positive regulation of macrophage derived foam cell differentiation|peptidyl-serine phosphorylation|enzyme binding|platelet activation|negative regulation of glial cell apoptotic process|intracellular signal transduction|positive regulation of keratinocyte differentiation|metal ion binding|positive regulation of B cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of glial cell proliferation|extracellular exosome|positive regulation of protein localization to plasma membrane|regulation of bicellular tight junction assembly "hsa04270,hsa04750" Vascular smooth muscle contraction|Inflammatory mediator regulation of TRP channels PRKCI 2055.790831 1753.843913 2357.737749 1.344325872 0.426882898 0.184719355 1 18.17597852 25.48697468 5584 protein kinase C iota "GO:0000139,GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0005515,GO:0005524,GO:0005543,GO:0005634,GO:0005654,GO:0005768,GO:0005829,GO:0005886,GO:0005923,GO:0006468,GO:0006612,GO:0007010,GO:0007015,GO:0010976,GO:0015630,GO:0016192,GO:0016324,GO:0016477,GO:0018105,GO:0031252,GO:0032869,GO:0034351,GO:0035089,GO:0035556,GO:0042462,GO:0043066,GO:0043220,GO:0043524,GO:0045171,GO:0045197,GO:0045216,GO:0045747,GO:0046326,GO:0046872,GO:0046903,GO:0048194,GO:0051092,GO:0060252,GO:0061024,GO:0070062,GO:0070555,GO:0070830,GO:0098685,GO:0098978,GO:0099072,GO:1903078,GO:2000353" Golgi membrane|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|phospholipid binding|nucleus|nucleoplasm|endosome|cytosol|plasma membrane|bicellular tight junction|protein phosphorylation|protein targeting to membrane|cytoskeleton organization|actin filament organization|positive regulation of neuron projection development|microtubule cytoskeleton|vesicle-mediated transport|apical plasma membrane|cell migration|peptidyl-serine phosphorylation|cell leading edge|cellular response to insulin stimulus|negative regulation of glial cell apoptotic process|establishment of apical/basal cell polarity|intracellular signal transduction|eye photoreceptor cell development|negative regulation of apoptotic process|Schmidt-Lanterman incisure|negative regulation of neuron apoptotic process|intercellular bridge|establishment or maintenance of epithelial cell apical/basal polarity|cell-cell junction organization|positive regulation of Notch signaling pathway|positive regulation of glucose import|metal ion binding|secretion|Golgi vesicle budding|positive regulation of NF-kappaB transcription factor activity|positive regulation of glial cell proliferation|membrane organization|extracellular exosome|response to interleukin-1|bicellular tight junction assembly|Schaffer collateral - CA1 synapse|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels|positive regulation of protein localization to plasma membrane|positive regulation of endothelial cell apoptotic process "hsa04015,hsa04144,hsa04390,hsa04530,hsa04611,hsa04910,hsa05165" Rap1 signaling pathway|Endocytosis|Hippo signaling pathway|Tight junction|Platelet activation|Insulin signaling pathway|Human papillomavirus infection PRKCSH 7548.535309 6899.670673 8197.399946 1.188085683 0.248638885 0.450203491 1 155.3084351 192.4680898 5589 protein kinase C substrate 80K-H "GO:0001889,GO:0005080,GO:0005509,GO:0005515,GO:0005783,GO:0005788,GO:0006457,GO:0006491,GO:0017177,GO:0035556,GO:0043231,GO:0043687,GO:0044267,GO:0044325,GO:0051219" liver development|protein kinase C binding|calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|N-glycan processing|glucosidase II complex|intracellular signal transduction|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process|ion channel binding|phosphoprotein binding hsa04141 Protein processing in endoplasmic reticulum PRKCZ 980.5103084 820.0844224 1140.936194 1.391242369 0.476373774 0.178117321 1 5.936875774 8.61542461 5590 protein kinase C zeta "GO:0000226,GO:0001725,GO:0001954,GO:0004672,GO:0004674,GO:0004698,GO:0005515,GO:0005524,GO:0005635,GO:0005737,GO:0005768,GO:0005815,GO:0005829,GO:0005886,GO:0005911,GO:0005923,GO:0006468,GO:0006954,GO:0007165,GO:0007179,GO:0007616,GO:0008284,GO:0014069,GO:0015459,GO:0016020,GO:0016324,GO:0016363,GO:0016477,GO:0018105,GO:0019901,GO:0030010,GO:0030054,GO:0031252,GO:0031333,GO:0031584,GO:0031982,GO:0032148,GO:0032733,GO:0032736,GO:0032753,GO:0032754,GO:0032869,GO:0035556,GO:0035748,GO:0043066,GO:0043203,GO:0043274,GO:0043560,GO:0044877,GO:0045121,GO:0045179,GO:0045630,GO:0046627,GO:0046628,GO:0046872,GO:0047496,GO:0048471,GO:0050732,GO:0051092,GO:0051222,GO:0051346,GO:0051899,GO:0060081,GO:0060291,GO:0070062,GO:0070374,GO:0070528,GO:0071889,GO:0072659,GO:0098685,GO:0098696,GO:0098978,GO:1990138,GO:2000463,GO:2000553" microtubule cytoskeleton organization|stress fiber|positive regulation of cell-matrix adhesion|protein kinase activity|protein serine/threonine kinase activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|nuclear envelope|cytoplasm|endosome|microtubule organizing center|cytosol|plasma membrane|cell-cell junction|bicellular tight junction|protein phosphorylation|inflammatory response|signal transduction|transforming growth factor beta receptor signaling pathway|long-term memory|positive regulation of cell population proliferation|postsynaptic density|potassium channel regulator activity|membrane|apical plasma membrane|nuclear matrix|cell migration|peptidyl-serine phosphorylation|protein kinase binding|establishment of cell polarity|cell junction|cell leading edge|negative regulation of protein-containing complex assembly|activation of phospholipase D activity|vesicle|activation of protein kinase B activity|positive regulation of interleukin-10 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|cellular response to insulin stimulus|intracellular signal transduction|myelin sheath abaxonal region|negative regulation of apoptotic process|axon hillock|phospholipase binding|insulin receptor substrate binding|protein-containing complex binding|membrane raft|apical cortex|positive regulation of T-helper 2 cell differentiation|negative regulation of insulin receptor signaling pathway|positive regulation of insulin receptor signaling pathway|metal ion binding|vesicle transport along microtubule|perinuclear region of cytoplasm|negative regulation of peptidyl-tyrosine phosphorylation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein transport|negative regulation of hydrolase activity|membrane depolarization|membrane hyperpolarization|long-term synaptic potentiation|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|protein kinase C signaling|14-3-3 protein binding|protein localization to plasma membrane|Schaffer collateral - CA1 synapse|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|glutamatergic synapse|neuron projection extension|positive regulation of excitatory postsynaptic potential|positive regulation of T-helper 2 cell cytokine production "hsa04015,hsa04062,hsa04071,hsa04144,hsa04360,hsa04390,hsa04530,hsa04611,hsa04910,hsa04926,hsa04930,hsa04931,hsa04933,hsa05165,hsa05418" Rap1 signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Platelet activation|Insulin signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Human papillomavirus infection|Fluid shear stress and atherosclerosis PRKD1 356.6951643 372.4888404 340.9014881 0.915199198 -0.127842306 0.780276371 1 2.250685481 2.148554479 5587 protein kinase D1 "GO:0000421,GO:0001525,GO:0001938,GO:0004674,GO:0004697,GO:0004698,GO:0005515,GO:0005524,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0006954,GO:0007030,GO:0007165,GO:0007229,GO:0007265,GO:0007399,GO:0010508,GO:0010595,GO:0010837,GO:0010976,GO:0016301,GO:0018105,GO:0018107,GO:0030148,GO:0030154,GO:0031647,GO:0032793,GO:0033138,GO:0034198,GO:0034599,GO:0035556,GO:0035924,GO:0038033,GO:0042802,GO:0043123,GO:0043536,GO:0043552,GO:0045087,GO:0045669,GO:0045766,GO:0045806,GO:0045944,GO:0046777,GO:0046872,GO:0048010,GO:0048193,GO:0051092,GO:0060548,GO:0071447,GO:0089700,GO:1901727,GO:2001028,GO:2001044" autophagosome membrane|angiogenesis|positive regulation of endothelial cell proliferation|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|protein phosphorylation|apoptotic process|inflammatory response|Golgi organization|signal transduction|integrin-mediated signaling pathway|Ras protein signal transduction|nervous system development|positive regulation of autophagy|positive regulation of endothelial cell migration|regulation of keratinocyte proliferation|positive regulation of neuron projection development|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sphingolipid biosynthetic process|cell differentiation|regulation of protein stability|positive regulation of CREB transcription factor activity|positive regulation of peptidyl-serine phosphorylation|cellular response to amino acid starvation|cellular response to oxidative stress|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|innate immune response|positive regulation of osteoblast differentiation|positive regulation of angiogenesis|negative regulation of endocytosis|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|metal ion binding|vascular endothelial growth factor receptor signaling pathway|Golgi vesicle transport|positive regulation of NF-kappaB transcription factor activity|negative regulation of cell death|cellular response to hydroperoxide|protein kinase D signaling|positive regulation of histone deacetylase activity|positive regulation of endothelial cell chemotaxis|regulation of integrin-mediated signaling pathway "hsa04015,hsa04925" Rap1 signaling pathway|Aldosterone synthesis and secretion PRKD2 705.1546362 687.1251906 723.1840817 1.052477906 0.073789948 0.84814778 1 10.42866853 11.44874233 25865 protein kinase D2 "GO:0001525,GO:0001938,GO:0002250,GO:0004672,GO:0004674,GO:0004698,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006468,GO:0007155,GO:0008219,GO:0010595,GO:0018105,GO:0018107,GO:0030148,GO:0030949,GO:0032743,GO:0032757,GO:0032793,GO:0033138,GO:0035556,GO:0035924,GO:0038033,GO:0043536,GO:0045743,GO:0045766,GO:0045785,GO:0045944,GO:0046777,GO:0046872,GO:0048010,GO:0050852,GO:0050862,GO:0051091,GO:0051092,GO:0061154,GO:0070374,GO:0089700,GO:1901727,GO:1902533,GO:2000573,GO:2001028" angiogenesis|positive regulation of endothelial cell proliferation|adaptive immune response|protein kinase activity|protein serine/threonine kinase activity|calcium-dependent protein kinase C activity|protein kinase C binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|protein phosphorylation|cell adhesion|cell death|positive regulation of endothelial cell migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sphingolipid biosynthetic process|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of interleukin-2 production|positive regulation of interleukin-8 production|positive regulation of CREB transcription factor activity|positive regulation of peptidyl-serine phosphorylation|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|metal ion binding|vascular endothelial growth factor receptor signaling pathway|T cell receptor signaling pathway|positive regulation of T cell receptor signaling pathway|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|endothelial tube morphogenesis|positive regulation of ERK1 and ERK2 cascade|protein kinase D signaling|positive regulation of histone deacetylase activity|positive regulation of intracellular signal transduction|positive regulation of DNA biosynthetic process|positive regulation of endothelial cell chemotaxis "hsa04015,hsa04925" Rap1 signaling pathway|Aldosterone synthesis and secretion PRKD3 1802.221577 1729.48497 1874.958185 1.084113604 0.116515945 0.72094586 1 14.12323645 15.97073686 23683 protein kinase D3 "GO:0004697,GO:0004698,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0007205,GO:0016020,GO:0016301,GO:0030148,GO:0046872,GO:0089700" protein kinase C activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|protein kinase C-activating G protein-coupled receptor signaling pathway|membrane|kinase activity|sphingolipid biosynthetic process|metal ion binding|protein kinase D signaling "hsa04015,hsa04925" Rap1 signaling pathway|Aldosterone synthesis and secretion PRKDC 28176.75296 27594.62287 28758.88305 1.04219156 0.059620477 0.876861755 1 103.8390891 112.8819105 5591 "protein kinase, DNA-activated, catalytic subunit" "GO:0000460,GO:0000723,GO:0000781,GO:0001756,GO:0001933,GO:0002218,GO:0002326,GO:0002328,GO:0002360,GO:0002638,GO:0003690,GO:0003723,GO:0004672,GO:0004674,GO:0004677,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0005958,GO:0006302,GO:0006303,GO:0006464,GO:0006468,GO:0006974,GO:0007420,GO:0007507,GO:0008134,GO:0008630,GO:0010332,GO:0014823,GO:0016020,GO:0016233,GO:0016567,GO:0018105,GO:0018107,GO:0019899,GO:0019904,GO:0031648,GO:0032040,GO:0032481,GO:0032869,GO:0032991,GO:0032993,GO:0033077,GO:0033152,GO:0033153,GO:0034462,GO:0034511,GO:0035234,GO:0042752,GO:0043065,GO:0043066,GO:0045087,GO:0045621,GO:0045648,GO:0045727,GO:0045944,GO:0048146,GO:0048511,GO:0048536,GO:0048538,GO:0048639,GO:0048660,GO:0050678,GO:0070419,GO:0072431,GO:0097681,GO:0106310,GO:0106311,GO:1902036,GO:1905221,GO:2000773,GO:2001034,GO:2001229" "maturation of 5.8S rRNA|telomere maintenance|chromosome, telomeric region|somitogenesis|negative regulation of protein phosphorylation|activation of innate immune response|B cell lineage commitment|pro-B cell differentiation|T cell lineage commitment|negative regulation of immunoglobulin production|double-stranded DNA binding|RNA binding|protein kinase activity|protein serine/threonine kinase activity|DNA-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytosol|DNA-dependent protein kinase-DNA ligase 4 complex|double-strand break repair|double-strand break repair via nonhomologous end joining|cellular protein modification process|protein phosphorylation|cellular response to DNA damage stimulus|brain development|heart development|transcription factor binding|intrinsic apoptotic signaling pathway in response to DNA damage|response to gamma radiation|response to activity|membrane|telomere capping|protein ubiquitination|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|enzyme binding|protein domain specific binding|protein destabilization|small-subunit processome|positive regulation of type I interferon production|cellular response to insulin stimulus|protein-containing complex|protein-DNA complex|T cell differentiation in thymus|immunoglobulin V(D)J recombination|T cell receptor V(D)J recombination|small-subunit processome assembly|U3 snoRNA binding|ectopic germ cell programmed cell death|regulation of circadian rhythm|positive regulation of apoptotic process|negative regulation of apoptotic process|innate immune response|positive regulation of lymphocyte differentiation|positive regulation of erythrocyte differentiation|positive regulation of translation|positive regulation of transcription by RNA polymerase II|positive regulation of fibroblast proliferation|rhythmic process|spleen development|thymus development|positive regulation of developmental growth|regulation of smooth muscle cell proliferation|regulation of epithelial cell proliferation|nonhomologous end joining complex|signal transduction involved in mitotic G1 DNA damage checkpoint|double-strand break repair via alternative nonhomologous end joining|protein serine kinase activity|protein threonine kinase activity|regulation of hematopoietic stem cell differentiation|positive regulation of platelet formation|negative regulation of cellular senescence|positive regulation of double-strand break repair via nonhomologous end joining|negative regulation of response to gamma radiation" "hsa03450,hsa04110" Non-homologous end-joining|Cell cycle other PRKG2 175.1853088 155.2882632 195.0823545 1.256259491 0.329134496 0.562619503 1 1.051163152 1.377416922 5593 protein kinase cGMP-dependent 2 "GO:0004672,GO:0004692,GO:0005524,GO:0005829,GO:0006468,GO:0007165,GO:0016324,GO:0030553,GO:0031965,GO:0036289,GO:0042802,GO:0072659,GO:2001226" protein kinase activity|cGMP-dependent protein kinase activity|ATP binding|cytosol|protein phosphorylation|signal transduction|apical plasma membrane|cGMP binding|nuclear membrane|peptidyl-serine autophosphorylation|identical protein binding|protein localization to plasma membrane|negative regulation of chloride transport "hsa04022,hsa04540,hsa04611,hsa04713,hsa04714,hsa04730,hsa04740,hsa04923,hsa04924,hsa04970" cGMP-PKG signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term depression|Olfactory transduction|Regulation of lipolysis in adipocytes|Renin secretion|Salivary secretion PRKRA 612.9690708 548.0762229 677.8619186 1.236802274 0.306614876 0.431372069 1 14.35270279 18.51611615 8575 protein activator of interferon induced protein kinase EIF2AK2 "GO:0003723,GO:0003725,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006955,GO:0008047,GO:0008285,GO:0009615,GO:0010586,GO:0016020,GO:0016032,GO:0019899,GO:0030422,GO:0031054,GO:0034599,GO:0035196,GO:0042473,GO:0042474,GO:0042802,GO:0042803,GO:0048471,GO:0048705,GO:0050790,GO:0050821,GO:0070578,GO:0070883,GO:2001244" RNA binding|double-stranded RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|immune response|enzyme activator activity|negative regulation of cell population proliferation|response to virus|miRNA metabolic process|membrane|viral process|enzyme binding|production of siRNA involved in RNA interference|pre-miRNA processing|cellular response to oxidative stress|production of miRNAs involved in gene silencing by miRNA|outer ear morphogenesis|middle ear morphogenesis|identical protein binding|protein homodimerization activity|perinuclear region of cytoplasm|skeletal system morphogenesis|regulation of catalytic activity|protein stabilization|RISC-loading complex|pre-miRNA binding|positive regulation of intrinsic apoptotic signaling pathway PRKRIP1 668.6283455 648.5568638 688.6998272 1.061895827 0.086642243 0.823580198 1 15.21404223 16.8516512 79706 PRKR interacting protein 1 "GO:0003014,GO:0003725,GO:0004860,GO:0005515,GO:0005681,GO:0005730,GO:0006397,GO:0006469,GO:0008380,GO:0019901,GO:0042326,GO:0070062" renal system process|double-stranded RNA binding|protein kinase inhibitor activity|protein binding|spliceosomal complex|nucleolus|mRNA processing|negative regulation of protein kinase activity|RNA splicing|protein kinase binding|negative regulation of phosphorylation|extracellular exosome PRKX 258.9097736 254.7539481 263.0655992 1.032626192 0.046318096 0.933634694 1 2.114452434 2.27749266 5613 protein kinase X-linked "GO:0001525,GO:0001935,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005952,GO:0007155,GO:0007165,GO:0018105,GO:0030099,GO:0030155,GO:0030334,GO:0031589,GO:0043542,GO:0046777,GO:0060562,GO:0060993,GO:0106310,GO:0106311,GO:2000696" angiogenesis|endothelial cell proliferation|cAMP-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cAMP-dependent protein kinase complex|cell adhesion|signal transduction|peptidyl-serine phosphorylation|myeloid cell differentiation|regulation of cell adhesion|regulation of cell migration|cell-substrate adhesion|endothelial cell migration|protein autophosphorylation|epithelial tube morphogenesis|kidney morphogenesis|protein serine kinase activity|protein threonine kinase activity|regulation of epithelial cell differentiation involved in kidney development PRLR 262.7968914 183.7070303 341.8867525 1.86104338 0.896111684 0.070201935 1 0.727395278 1.412026683 5618 prolactin receptor "GO:0004896,GO:0004923,GO:0004924,GO:0004925,GO:0005127,GO:0005515,GO:0005576,GO:0005886,GO:0006694,GO:0007171,GO:0007566,GO:0007595,GO:0008284,GO:0009897,GO:0009986,GO:0016021,GO:0017046,GO:0019221,GO:0019955,GO:0031904,GO:0038161,GO:0038165,GO:0042976,GO:0043066,GO:0043235,GO:0046872,GO:0048861,GO:0060397,GO:0120162" cytokine receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|prolactin receptor activity|ciliary neurotrophic factor receptor binding|protein binding|extracellular region|plasma membrane|steroid biosynthetic process|activation of transmembrane receptor protein tyrosine kinase activity|embryo implantation|lactation|positive regulation of cell population proliferation|external side of plasma membrane|cell surface|integral component of membrane|peptide hormone binding|cytokine-mediated signaling pathway|cytokine binding|endosome lumen|prolactin signaling pathway|oncostatin-M-mediated signaling pathway|activation of Janus kinase activity|negative regulation of apoptotic process|receptor complex|metal ion binding|leukemia inhibitory factor signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|positive regulation of cold-induced thermogenesis "hsa04060,hsa04080,hsa04151,hsa04630,hsa04917" Cytokine-cytokine receptor interaction|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Prolactin signaling pathway PRMT1 4182.179747 4764.203316 3600.156178 0.755668039 -0.404175489 0.205562584 1 140.2034229 110.5110234 3276 protein arginine methyltransferase 1 "GO:0001701,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006479,GO:0006977,GO:0007166,GO:0008168,GO:0008170,GO:0008276,GO:0008284,GO:0008327,GO:0016274,GO:0016571,GO:0018216,GO:0019899,GO:0019919,GO:0031175,GO:0034709,GO:0035241,GO:0035242,GO:0042054,GO:0042802,GO:0043985,GO:0044020,GO:0045648,GO:0045652,GO:0045653,GO:0046985,GO:0048273,GO:0051260,GO:1900745,GO:1904047" "in utero embryonic development|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein methylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell surface receptor signaling pathway|methyltransferase activity|N-methyltransferase activity|protein methyltransferase activity|positive regulation of cell population proliferation|methyl-CpG binding|protein-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation|enzyme binding|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|neuron projection development|methylosome|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|identical protein binding|histone H4-R3 methylation|histone methyltransferase activity (H4-R3 specific)|positive regulation of erythrocyte differentiation|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|positive regulation of hemoglobin biosynthetic process|mitogen-activated protein kinase p38 binding|protein homooligomerization|positive regulation of p38MAPK cascade|S-adenosyl-L-methionine binding" "hsa04068,hsa04922" FoxO signaling pathway|Glucagon signaling pathway PRMT2 1781.84427 1548.822808 2014.865732 1.300901383 0.3795116 0.243558887 1 6.889979033 9.349280833 3275 protein arginine methyltransferase 2 "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006479,GO:0007165,GO:0008469,GO:0016274,GO:0016571,GO:0019919,GO:0030331,GO:0032088,GO:0033142,GO:0034969,GO:0035242,GO:0042054,GO:0042803,GO:0042974,GO:0042975,GO:0043065,GO:0044877,GO:0045892,GO:0045893,GO:0046966,GO:0048588,GO:0050681,GO:0060765,GO:2000134" "transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|protein methylation|signal transduction|histone-arginine N-methyltransferase activity|protein-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|estrogen receptor binding|negative regulation of NF-kappaB transcription factor activity|progesterone receptor binding|histone arginine methylation|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|protein homodimerization activity|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|positive regulation of apoptotic process|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|developmental cell growth|androgen receptor binding|regulation of androgen receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle" PRMT3 327.2114606 377.5636202 276.859301 0.733278542 -0.447566772 0.331431386 1 6.011400629 4.597911192 10196 protein arginine methyltransferase 3 "GO:0005515,GO:0005737,GO:0005829,GO:0006479,GO:0008168,GO:0016274,GO:0031397,GO:0035246,GO:0043022,GO:0046872" protein binding|cytoplasm|cytosol|protein methylation|methyltransferase activity|protein-arginine N-methyltransferase activity|negative regulation of protein ubiquitination|peptidyl-arginine N-methylation|ribosome binding|metal ion binding PRMT5 2248.186846 2479.537431 2016.836261 0.813392141 -0.297977042 0.352049534 1 52.56585332 44.59843516 10419 protein arginine methyltransferase 5 "GO:0000387,GO:0002039,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006353,GO:0006355,GO:0007088,GO:0008168,GO:0008327,GO:0008469,GO:0016274,GO:0018216,GO:0019918,GO:0032922,GO:0034709,GO:0034969,GO:0035097,GO:0035243,GO:0035246,GO:0042118,GO:0042802,GO:0043021,GO:0043985,GO:0044020,GO:0044030,GO:0045596,GO:0045892,GO:0046982,GO:0048714,GO:0070372,GO:0070888,GO:0090161,GO:0097421,GO:1901796,GO:1904992" "spliceosomal snRNP assembly|p53 binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|DNA-templated transcription, termination|regulation of transcription, DNA-templated|regulation of mitotic nuclear division|methyltransferase activity|methyl-CpG binding|histone-arginine N-methyltransferase activity|protein-arginine N-methyltransferase activity|peptidyl-arginine methylation|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|circadian regulation of gene expression|methylosome|histone arginine methylation|histone methyltransferase complex|protein-arginine omega-N symmetric methyltransferase activity|peptidyl-arginine N-methylation|endothelial cell activation|identical protein binding|ribonucleoprotein complex binding|histone H4-R3 methylation|histone methyltransferase activity (H4-R3 specific)|regulation of DNA methylation|negative regulation of cell differentiation|negative regulation of transcription, DNA-templated|protein heterodimerization activity|positive regulation of oligodendrocyte differentiation|regulation of ERK1 and ERK2 cascade|E-box binding|Golgi ribbon formation|liver regeneration|regulation of signal transduction by p53 class mediator|positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" hsa03013 RNA transport PRMT6 365.3789515 427.2964627 303.4614403 0.710189451 -0.493724164 0.267722975 1 8.256794515 6.116480893 55170 protein arginine methyltransferase 6 "GO:0000122,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006284,GO:0008469,GO:0010821,GO:0016032,GO:0016274,GO:0016571,GO:0019919,GO:0031064,GO:0034970,GO:0035241,GO:0035242,GO:0042054,GO:0042393,GO:0043985,GO:0044020,GO:0045652,GO:0045892,GO:0051572,GO:0070611,GO:0070612,GO:0090398,GO:1901796" "negative regulation of transcription by RNA polymerase II|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|base-excision repair|histone-arginine N-methyltransferase activity|regulation of mitochondrion organization|viral process|protein-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|negative regulation of histone deacetylation|histone H3-R2 methylation|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|histone binding|histone H4-R3 methylation|histone methyltransferase activity (H4-R3 specific)|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|negative regulation of histone H3-K4 methylation|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H2A-R3 specific)|cellular senescence|regulation of signal transduction by p53 class mediator" PRMT7 373.0114102 376.5486643 369.4741562 0.981212234 -0.027362872 0.957220071 1 2.770719375 2.835772758 54496 protein arginine methyltransferase 7 "GO:0000387,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006349,GO:0008469,GO:0008757,GO:0016277,GO:0016571,GO:0018216,GO:0019918,GO:0030154,GO:0034969,GO:0035241,GO:0035243,GO:0042393,GO:0043021,GO:0043046,GO:0043393,GO:0043985,GO:0044020" "spliceosomal snRNP assembly|fibrillar center|protein binding|nucleus|nucleoplasm|cytosol|regulation of gene expression by genetic imprinting|histone-arginine N-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|[myelin basic protein]-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|cell differentiation|histone arginine methylation|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|histone binding|ribonucleoprotein complex binding|DNA methylation involved in gamete generation|regulation of protein binding|histone H4-R3 methylation|histone methyltransferase activity (H4-R3 specific)" PRMT9 232.6815004 246.6343003 218.7287005 0.886854343 -0.173230919 0.741405987 1 1.98967143 1.840558353 90826 protein arginine methyltransferase 9 "GO:0005515,GO:0005737,GO:0006397,GO:0016274,GO:0019918,GO:0035241,GO:0035243" "protein binding|cytoplasm|mRNA processing|protein-arginine N-methyltransferase activity|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity" PRNP 8904.691411 8377.446563 9431.93626 1.125872447 0.17104339 0.60786285 1 174.5323384 204.9656235 5621 prion protein "GO:0001540,GO:0001933,GO:0002020,GO:0005507,GO:0005509,GO:0005515,GO:0005539,GO:0005634,GO:0005737,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006878,GO:0006979,GO:0007050,GO:0007611,GO:0007616,GO:0008017,GO:0009986,GO:0010951,GO:0010955,GO:0014069,GO:0015631,GO:0016234,GO:0019828,GO:0019898,GO:0030425,GO:0031362,GO:0031648,GO:0031802,GO:0031805,GO:0031965,GO:0032689,GO:0032700,GO:0032703,GO:0035584,GO:0038023,GO:0042802,GO:0043231,GO:0043433,GO:0043525,GO:0044877,GO:0045121,GO:0046007,GO:0050730,GO:0050731,GO:0050860,GO:0051260,GO:0061098,GO:0070062,GO:0070885,GO:0071280,GO:0090314,GO:0090647,GO:0097062,GO:0098794,GO:1900449,GO:1901216,GO:1902430,GO:1902938,GO:1902951,GO:1902992,GO:1903136,GO:1904645,GO:1904646,GO:1905664,GO:1990535" amyloid-beta binding|negative regulation of protein phosphorylation|protease binding|copper ion binding|calcium ion binding|protein binding|glycosaminoglycan binding|nucleus|cytoplasm|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|cellular copper ion homeostasis|response to oxidative stress|cell cycle arrest|learning or memory|long-term memory|microtubule binding|cell surface|negative regulation of endopeptidase activity|negative regulation of protein processing|postsynaptic density|tubulin binding|inclusion body|aspartic-type endopeptidase inhibitor activity|extrinsic component of membrane|dendrite|anchored component of external side of plasma membrane|protein destabilization|type 5 metabotropic glutamate receptor binding|type 8 metabotropic glutamate receptor binding|nuclear membrane|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|calcium-mediated signaling using intracellular calcium source|signaling receptor activity|identical protein binding|intracellular membrane-bounded organelle|negative regulation of DNA-binding transcription factor activity|positive regulation of neuron apoptotic process|protein-containing complex binding|membrane raft|negative regulation of activated T cell proliferation|regulation of peptidyl-tyrosine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of T cell receptor signaling pathway|protein homooligomerization|positive regulation of protein tyrosine kinase activity|extracellular exosome|negative regulation of calcineurin-NFAT signaling cascade|cellular response to copper ion|positive regulation of protein targeting to membrane|modulation of age-related behavioral decline|dendritic spine maintenance|postsynapse|regulation of glutamate receptor signaling pathway|positive regulation of neuron death|negative regulation of amyloid-beta formation|regulation of intracellular calcium activated chloride channel activity|negative regulation of dendritic spine maintenance|negative regulation of amyloid precursor protein catabolic process|cuprous ion binding|response to amyloid-beta|cellular response to amyloid-beta|regulation of calcium ion import across plasma membrane|neuron projection maintenance "hsa04216,hsa05020,hsa05022" Ferroptosis|Prion disease|Pathways of neurodegeneration - multiple diseases PROB1 126.162342 138.0340117 114.2906723 0.82798921 -0.272316127 0.671346899 1 1.549066195 1.337859736 389333 proline rich basic protein 1 GO:0005654 nucleoplasm PROC 8.44897642 5.074779842 11.823173 2.329790329 1.220200125 0.437754762 1 0.112826908 0.274186113 5624 "protein C, inactivator of coagulation factors Va and VIIIa" "GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005788,GO:0005794,GO:0005796,GO:0006508,GO:0006888,GO:0007596,GO:0030195,GO:0043066,GO:0043687,GO:0044267,GO:0050728,GO:0050819,GO:1903142" serine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|Golgi lumen|proteolysis|endoplasmic reticulum to Golgi vesicle-mediated transport|blood coagulation|negative regulation of blood coagulation|negative regulation of apoptotic process|post-translational protein modification|cellular protein metabolic process|negative regulation of inflammatory response|negative regulation of coagulation|positive regulation of establishment of endothelial barrier hsa04610 Complement and coagulation cascades PROCA1 113.7750295 99.4656849 128.0843742 1.287724247 0.364823688 0.579851566 1 1.834517861 2.464113722 147011 protein interacting with cyclin A1 "GO:0004623,GO:0006644,GO:0030332,GO:0050482" phospholipase A2 activity|phospholipid metabolic process|cyclin binding|arachidonic acid secretion PROCR 1348.689668 1506.194657 1191.18468 0.790857061 -0.338511129 0.314152931 1 52.75480349 43.51870223 10544 protein C receptor "GO:0005515,GO:0005576,GO:0005615,GO:0005813,GO:0005886,GO:0005887,GO:0005925,GO:0007596,GO:0009986,GO:0038023,GO:0048471,GO:0050819,GO:0070062" protein binding|extracellular region|extracellular space|centrosome|plasma membrane|integral component of plasma membrane|focal adhesion|blood coagulation|cell surface|signaling receptor activity|perinuclear region of cytoplasm|negative regulation of coagulation|extracellular exosome hsa04610 Complement and coagulation cascades PROKR1 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.059953276 0.024282558 10887 prokineticin receptor 1 "GO:0004930,GO:0004983,GO:0005886,GO:0005887,GO:0007186,GO:0007218" G protein-coupled receptor activity|neuropeptide Y receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway PROM2 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.05183939 0.031494351 150696 prominin 2 "GO:0001934,GO:0005515,GO:0005887,GO:0005902,GO:0005929,GO:0009986,GO:0015485,GO:0016323,GO:0016324,GO:0031346,GO:0031410,GO:0031528,GO:0042995,GO:0043087,GO:0044393,GO:0045121,GO:0048550,GO:0060170,GO:0070062,GO:0071914,GO:2000369,GO:2001287" positive regulation of protein phosphorylation|protein binding|integral component of plasma membrane|microvillus|cilium|cell surface|cholesterol binding|basolateral plasma membrane|apical plasma membrane|positive regulation of cell projection organization|cytoplasmic vesicle|microvillus membrane|cell projection|regulation of GTPase activity|microspike|membrane raft|negative regulation of pinocytosis|ciliary membrane|extracellular exosome|prominosome|regulation of clathrin-dependent endocytosis|negative regulation of caveolin-mediated endocytosis PRORP 1061.238402 1051.494383 1070.982421 1.018533658 0.026493656 0.942283221 1 17.91270806 19.03060358 9692 protein only RNase P catalytic subunit "GO:0001682,GO:0004526,GO:0005654,GO:0005739,GO:0005759,GO:0030678,GO:0046872,GO:0070901,GO:0090502,GO:0090646,GO:0097745" "tRNA 5'-leader removal|ribonuclease P activity|nucleoplasm|mitochondrion|mitochondrial matrix|mitochondrial ribonuclease P complex|metal ion binding|mitochondrial tRNA methylation|RNA phosphodiester bond hydrolysis, endonucleolytic|mitochondrial tRNA processing|mitochondrial tRNA 5'-end processing" PROS1 353.3264109 310.5765263 396.0762955 1.275293726 0.350829567 0.436543505 1 4.535641698 6.033438527 5627 protein S "GO:0000139,GO:0002576,GO:0004866,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005789,GO:0005796,GO:0005886,GO:0006888,GO:0007596,GO:0010951,GO:0030449,GO:0031093,GO:0042730,GO:0050900,GO:0070062,GO:0072562" Golgi membrane|platelet degranulation|endopeptidase inhibitor activity|calcium ion binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum membrane|Golgi lumen|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|blood coagulation|negative regulation of endopeptidase activity|regulation of complement activation|platelet alpha granule lumen|fibrinolysis|leukocyte migration|extracellular exosome|blood microparticle hsa04610 Complement and coagulation cascades PROSER1 891.7271473 879.9668246 903.48747 1.026729014 0.038055459 0.918875542 1 9.895030046 10.59714512 80209 proline and serine rich 1 PROSER2 841.252016 729.7533413 952.7506908 1.305579073 0.384689838 0.290452862 1 8.301759281 11.30548625 254427 proline and serine rich 2 GO:0005515 protein binding PROSER3 364.4936481 299.4120107 429.5752856 1.434729638 0.520778899 0.242769687 1 3.072778537 4.598511322 148137 proline and serine rich 3 GO:0005515 protein binding PROX1 8.434130644 4.059823873 12.80843742 3.154924404 1.657605437 0.28583743 1 0.021627828 0.071173412 5629 prospero homeobox 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001709,GO:0001822,GO:0001889,GO:0001938,GO:0001946,GO:0002088,GO:0002194,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007420,GO:0007623,GO:0008284,GO:0008285,GO:0010468,GO:0010595,GO:0016922,GO:0021516,GO:0021542,GO:0021707,GO:0021915,GO:0030240,GO:0030324,GO:0030910,GO:0031016,GO:0031667,GO:0042752,GO:0043049,GO:0043433,GO:0045071,GO:0045737,GO:0045787,GO:0045892,GO:0045944,GO:0046619,GO:0048845,GO:0050692,GO:0050693,GO:0055005,GO:0055009,GO:0055010,GO:0060042,GO:0060059,GO:0060214,GO:0060298,GO:0060412,GO:0060414,GO:0060421,GO:0060836,GO:0060838,GO:0061114,GO:0070309,GO:0070365,GO:0070858,GO:0072574,GO:0090425,GO:0097150,GO:1901978,GO:1990837,GO:2000179,GO:2000979" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cell fate determination|kidney development|liver development|positive regulation of endothelial cell proliferation|lymphangiogenesis|lens development in camera-type eye|hepatocyte cell migration|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|brain development|circadian rhythm|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of gene expression|positive regulation of endothelial cell migration|nuclear receptor binding|dorsal spinal cord development|dentate gyrus development|cerebellar granule cell differentiation|neural tube development|skeletal muscle thin filament assembly|lung development|olfactory placode formation|pancreas development|response to nutrient levels|regulation of circadian rhythm|otic placode formation|negative regulation of DNA-binding transcription factor activity|negative regulation of viral genome replication|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|optic placode formation involved in camera-type eye formation|venous blood vessel morphogenesis|DNA binding domain binding|LBD domain binding|ventricular cardiac myofibril assembly|atrial cardiac muscle tissue morphogenesis|ventricular cardiac muscle tissue morphogenesis|retina morphogenesis in camera-type eye|embryonic retina morphogenesis in camera-type eye|endocardium formation|positive regulation of sarcomere organization|ventricular septum morphogenesis|aorta smooth muscle tissue morphogenesis|positive regulation of heart growth|lymphatic endothelial cell differentiation|lymphatic endothelial cell fate commitment|branching involved in pancreas morphogenesis|lens fiber cell morphogenesis|hepatocyte differentiation|negative regulation of bile acid biosynthetic process|hepatocyte proliferation|acinar cell differentiation|neuronal stem cell population maintenance|positive regulation of cell cycle checkpoint|sequence-specific double-stranded DNA binding|positive regulation of neural precursor cell proliferation|positive regulation of forebrain neuron differentiation" PRPF18 334.8884567 329.8606897 339.9162237 1.030484184 0.043322362 0.93122902 1 8.589347175 9.232459629 8559 pre-mRNA processing factor 18 "GO:0000350,GO:0005515,GO:0005634,GO:0005681,GO:0005682,GO:0006397,GO:0008380,GO:0016607,GO:0046540,GO:0071021,GO:0071048" generation of catalytic spliceosome for second transesterification step|protein binding|nucleus|spliceosomal complex|U5 snRNP|mRNA processing|RNA splicing|nuclear speck|U4/U6 x U5 tri-snRNP complex|U2-type post-spliceosomal complex|nuclear retention of unspliced pre-mRNA at the site of transcription hsa03040 Spliceosome PRPF19 3575.121271 3677.185473 3473.057068 0.944487868 -0.08239583 0.796262887 1 79.69040304 78.50879956 27339 pre-mRNA processing factor 19 "GO:0000209,GO:0000244,GO:0000245,GO:0000349,GO:0000398,GO:0000974,GO:0001833,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0005737,GO:0005811,GO:0005819,GO:0006283,GO:0006303,GO:0008610,GO:0010498,GO:0016020,GO:0016607,GO:0034450,GO:0034613,GO:0035861,GO:0042802,GO:0045666,GO:0048026,GO:0048711,GO:0061630,GO:0070534,GO:0071006,GO:0071007,GO:0071013,GO:0072422" "protein polyubiquitination|spliceosomal tri-snRNP complex assembly|spliceosomal complex assembly|generation of catalytic spliceosome for first transesterification step|mRNA splicing, via spliceosome|Prp19 complex|inner cell mass cell proliferation|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|cytoplasm|lipid droplet|spindle|transcription-coupled nucleotide-excision repair|double-strand break repair via nonhomologous end joining|lipid biosynthetic process|proteasomal protein catabolic process|membrane|nuclear speck|ubiquitin-ubiquitin ligase activity|cellular protein localization|site of double-strand break|identical protein binding|positive regulation of neuron differentiation|positive regulation of mRNA splicing, via spliceosome|positive regulation of astrocyte differentiation|ubiquitin protein ligase activity|protein K63-linked ubiquitination|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|signal transduction involved in DNA damage checkpoint" "hsa03040,hsa04120" Spliceosome|Ubiquitin mediated proteolysis PRPF3 1141.042098 1084.98793 1197.096266 1.103326805 0.14186018 0.682089833 1 20.05504053 23.08041657 9129 pre-mRNA processing factor 3 "GO:0000244,GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0006397,GO:0008380,GO:0015030,GO:0016607,GO:0042802,GO:0046540,GO:0071005" "spliceosomal tri-snRNP complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytosol|mRNA processing|RNA splicing|Cajal body|nuclear speck|identical protein binding|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome" hsa03040 Spliceosome PRPF31 1238.074314 1285.949212 1190.199415 0.925541541 -0.111630351 0.744514471 1 34.08100001 32.90214221 26121 pre-mRNA processing factor 31 "GO:0000244,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005684,GO:0005687,GO:0005690,GO:0015030,GO:0016607,GO:0030621,GO:0030622,GO:0042802,GO:0043021,GO:0046540,GO:0048254,GO:0070990,GO:0071005,GO:0071011,GO:0071166,GO:0071339,GO:0097526" "spliceosomal tri-snRNP complex assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U2-type spliceosomal complex|U4 snRNP|U4atac snRNP|Cajal body|nuclear speck|U4 snRNA binding|U4atac snRNA binding|identical protein binding|ribonucleoprotein complex binding|U4/U6 x U5 tri-snRNP complex|snoRNA localization|snRNP binding|U2-type precatalytic spliceosome|precatalytic spliceosome|ribonucleoprotein complex localization|MLL1 complex|spliceosomal tri-snRNP complex" hsa03040 Spliceosome PRPF38A 1069.094785 1184.453615 953.7359552 0.805211739 -0.31255989 0.369925252 1 11.33567595 9.520800164 84950 pre-mRNA processing factor 38A "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0071005,GO:0071011" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U2-type precatalytic spliceosome|precatalytic spliceosome" hsa03040 Spliceosome PRPF38B 1168.992481 1210.84247 1127.142493 0.930874594 -0.103341272 0.765215485 1 15.78910904 15.33079693 55119 pre-mRNA processing factor 38B "GO:0003723,GO:0006397,GO:0008380,GO:0071011" RNA binding|mRNA processing|RNA splicing|precatalytic spliceosome hsa03040 Spliceosome PRPF39 655.9386743 656.6765115 655.200837 0.997752814 -0.003245653 0.997806044 1 9.416293515 9.799837589 55015 pre-mRNA processing factor 39 "GO:0000243,GO:0000395,GO:0005515,GO:0005685,GO:0071004" commitment complex|mRNA 5'-splice site recognition|protein binding|U1 snRNP|U2-type prespliceosome PRPF4 1449.094843 1533.598468 1364.591217 0.889796935 -0.168451965 0.613754266 1 26.42781633 24.52833761 9128 pre-mRNA processing factor 4 "GO:0000375,GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006396,GO:0008380,GO:0015030,GO:0016607,GO:0017070,GO:0030621,GO:0046540,GO:0071001,GO:0071005,GO:0097525" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|spliceosomal complex|RNA processing|RNA splicing|Cajal body|nuclear speck|U6 snRNA binding|U4 snRNA binding|U4/U6 x U5 tri-snRNP complex|U4/U6 snRNP|U2-type precatalytic spliceosome|spliceosomal snRNP complex" hsa03040 Spliceosome PRPF40A 2247.802339 2251.172338 2244.432341 0.997006006 -0.0043259 0.990791507 1 13.26051841 13.79031565 55660 pre-mRNA processing factor 40 homolog A "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005685,GO:0007010,GO:0007049,GO:0008360,GO:0016020,GO:0016363,GO:0016477,GO:0016607,GO:0032465,GO:0045292,GO:0051301,GO:0071004" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|U1 snRNP|cytoskeleton organization|cell cycle|regulation of cell shape|membrane|nuclear matrix|cell migration|nuclear speck|regulation of cytokinesis|mRNA cis splicing, via spliceosome|cell division|U2-type prespliceosome" hsa03040 Spliceosome PRPF40B 306.4912163 375.5337083 237.4487244 0.6322967 -0.661326406 0.15948182 1 3.724193758 2.456230459 25766 pre-mRNA processing factor 40 homolog B "GO:0000398,GO:0003723,GO:0005515,GO:0005685,GO:0016607,GO:0045292,GO:0071004" "mRNA splicing, via spliceosome|RNA binding|protein binding|U1 snRNP|nuclear speck|mRNA cis splicing, via spliceosome|U2-type prespliceosome" hsa03040 Spliceosome PRPF4B 1211.81907 1242.306105 1181.332035 0.950918643 -0.072606181 0.833644992 1 9.863367556 9.783280575 8899 pre-mRNA processing factor 4B "GO:0000398,GO:0003723,GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0006468,GO:0008380,GO:0016607,GO:0045292,GO:0071013,GO:0106310,GO:0106311" "mRNA splicing, via spliceosome|RNA binding|protein kinase activity|protein binding|ATP binding|nucleus|chromosome|protein phosphorylation|RNA splicing|nuclear speck|mRNA cis splicing, via spliceosome|catalytic step 2 spliceosome|protein serine kinase activity|protein threonine kinase activity" PRPF6 3889.772713 3937.014201 3842.531225 0.976001362 -0.035044933 0.913159508 1 65.44006575 66.62083638 24148 pre-mRNA processing factor 6 "GO:0000244,GO:0000245,GO:0000375,GO:0000398,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0006403,GO:0008380,GO:0016020,GO:0016607,GO:0043021,GO:0045944,GO:0046540,GO:0050681,GO:0071005,GO:0071013" "spliceosomal tri-snRNP complex assembly|spliceosomal complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|RNA localization|RNA splicing|membrane|nuclear speck|ribonucleoprotein complex binding|positive regulation of transcription by RNA polymerase II|U4/U6 x U5 tri-snRNP complex|androgen receptor binding|U2-type precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome PRPF8 17272.87789 16921.3459 17624.40988 1.04154894 0.058730629 0.869254512 1 117.5108289 127.6654853 10594 pre-mRNA processing factor 8 "GO:0000244,GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005682,GO:0006397,GO:0006508,GO:0008237,GO:0008380,GO:0016020,GO:0016607,GO:0017070,GO:0030619,GO:0030620,GO:0030623,GO:0046540,GO:0070122,GO:0070530,GO:0071005,GO:0071006,GO:0071007,GO:0071013,GO:0071222,GO:0071356,GO:0097157" "spliceosomal tri-snRNP complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U5 snRNP|mRNA processing|proteolysis|metallopeptidase activity|RNA splicing|membrane|nuclear speck|U6 snRNA binding|U1 snRNA binding|U2 snRNA binding|U5 snRNA binding|U4/U6 x U5 tri-snRNP complex|isopeptidase activity|K63-linked polyubiquitin modification-dependent protein binding|U2-type precatalytic spliceosome|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|pre-mRNA intronic binding" hsa03040 Spliceosome PRPS1 1180.664475 1234.186458 1127.142493 0.913267591 -0.130890458 0.70409431 1 30.19671021 28.76561125 5631 phosphoribosyl pyrophosphate synthetase 1 "GO:0000287,GO:0002189,GO:0004749,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006015,GO:0006144,GO:0006164,GO:0006221,GO:0007399,GO:0009116,GO:0009156,GO:0016301,GO:0016310,GO:0034418,GO:0042802,GO:0042803,GO:0046101" magnesium ion binding|ribose phosphate diphosphokinase complex|ribose phosphate diphosphokinase activity|protein binding|ATP binding|cytoplasm|cytosol|5-phosphoribose 1-diphosphate biosynthetic process|purine nucleobase metabolic process|purine nucleotide biosynthetic process|pyrimidine nucleotide biosynthetic process|nervous system development|nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process|kinase activity|phosphorylation|urate biosynthetic process|identical protein binding|protein homodimerization activity|hypoxanthine biosynthetic process "hsa00030,hsa00230" Pentose phosphate pathway|Purine metabolism PRPS2 1196.976762 1103.257138 1290.696386 1.169896248 0.22638059 0.508846976 1 22.6310579 27.61646799 5634 phosphoribosyl pyrophosphate synthetase 2 "GO:0000287,GO:0002189,GO:0004749,GO:0005515,GO:0005524,GO:0005737,GO:0006015,GO:0006139,GO:0006164,GO:0006167,GO:0009116,GO:0016208,GO:0016301,GO:0016310,GO:0019003,GO:0030246,GO:0031100,GO:0042802,GO:0042803,GO:0043531" magnesium ion binding|ribose phosphate diphosphokinase complex|ribose phosphate diphosphokinase activity|protein binding|ATP binding|cytoplasm|5-phosphoribose 1-diphosphate biosynthetic process|nucleobase-containing compound metabolic process|purine nucleotide biosynthetic process|AMP biosynthetic process|nucleoside metabolic process|AMP binding|kinase activity|phosphorylation|GDP binding|carbohydrate binding|animal organ regeneration|identical protein binding|protein homodimerization activity|ADP binding "hsa00030,hsa00230" Pentose phosphate pathway|Purine metabolism PRPSAP1 1024.70543 911.4304596 1137.980401 1.248565252 0.32027122 0.361675499 1 13.12503197 17.09336411 5635 phosphoribosyl pyrophosphate synthetase associated protein 1 "GO:0000287,GO:0002189,GO:0004749,GO:0004857,GO:0005515,GO:0005737,GO:0006015,GO:0006139,GO:0006164,GO:0042802,GO:0043086" magnesium ion binding|ribose phosphate diphosphokinase complex|ribose phosphate diphosphokinase activity|enzyme inhibitor activity|protein binding|cytoplasm|5-phosphoribose 1-diphosphate biosynthetic process|nucleobase-containing compound metabolic process|purine nucleotide biosynthetic process|identical protein binding|negative regulation of catalytic activity PRPSAP2 456.015113 527.7771036 384.2531225 0.728059478 -0.457871781 0.274042734 1 9.780478745 7.427504151 5636 phosphoribosyl pyrophosphate synthetase associated protein 2 "GO:0000287,GO:0002189,GO:0004749,GO:0004857,GO:0005515,GO:0005737,GO:0006015,GO:0006139,GO:0006164,GO:0009116,GO:0042802,GO:0043086" magnesium ion binding|ribose phosphate diphosphokinase complex|ribose phosphate diphosphokinase activity|enzyme inhibitor activity|protein binding|cytoplasm|5-phosphoribose 1-diphosphate biosynthetic process|nucleobase-containing compound metabolic process|purine nucleotide biosynthetic process|nucleoside metabolic process|identical protein binding|negative regulation of catalytic activity PRR11 3845.279684 3286.427426 4404.131942 1.340097124 0.422337565 0.185185468 1 24.9058739 34.8140052 55771 proline rich 11 "GO:0005634,GO:0005737,GO:0007050,GO:0016020,GO:0051726" nucleus|cytoplasm|cell cycle arrest|membrane|regulation of cell cycle PRR12 985.9210979 920.5650633 1051.277132 1.141991125 0.191551439 0.588743131 1 6.286862581 7.488806793 57479 proline rich 12 "GO:0005634,GO:0014069,GO:0043005" nucleus|postsynaptic density|neuron projection PRR13 1804.708987 1798.501976 1810.915998 1.006902423 0.009923881 0.977524742 1 82.43238041 86.5767257 54458 proline rich 13 "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol PRR14 599.2941351 556.1958707 642.3923996 1.154975133 0.20786179 0.596849257 1 13.36941562 16.10649299 78994 proline rich 14 "GO:0005515,GO:0005652,GO:0005654,GO:0005694,GO:0007517" protein binding|nuclear lamina|nucleoplasm|chromosome|muscle organ development PRR14L 1263.943567 1303.203463 1224.68367 0.93974863 -0.089653187 0.793383364 1 6.096116929 5.97559176 253143 proline rich 14 like PRR15 15.42005622 10.14955968 20.69055275 2.038566538 1.027555047 0.407126681 1 0.238091428 0.506272783 222171 proline rich 15 "GO:0005515,GO:0007275" protein binding|multicellular organism development PRR16 258.9637135 325.8008658 192.1265612 0.589705496 -0.761933455 0.124738195 1 3.98278168 2.449839349 51334 proline rich 16 "GO:0005515,GO:0045727,GO:0045793" protein binding|positive regulation of translation|positive regulation of cell size PRR19 68.8739913 60.8973581 76.85062449 1.261969762 0.335677342 0.671996814 1 1.453457283 1.913229863 284338 proline rich 19 GO:0005515 protein binding PRR22 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.33695226 0.151637768 163154 proline rich 22 PRR29 28.6144838 36.53841486 20.69055275 0.566268483 -0.82044186 0.419467065 1 0.556888899 0.328932572 92340 proline rich 29 PRR3 448.0911819 491.2386887 404.9436752 0.824331806 -0.278702935 0.508802955 1 10.23426845 8.799840306 80742 proline rich 3 "GO:0003723,GO:0005515,GO:0046872" RNA binding|protein binding|metal ion binding PRR36 30.39201755 23.34398727 37.44004783 1.603841169 0.681531276 0.498588374 1 0.264672174 0.442777529 80164 proline rich 36 PRR4 42.96020095 40.59823873 45.32216316 1.116357866 0.15879958 0.882851459 1 3.652144884 4.252725631 11272 proline rich 4 "GO:0001895,GO:0005515,GO:0005615,GO:0007601" retina homeostasis|protein binding|extracellular space|visual perception PRR5 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.078419434 0.059553391 55615 proline rich 5 "GO:0005515,GO:0005829,GO:0007049,GO:0014068,GO:0031932,GO:0032148,GO:0038203" protein binding|cytosol|cell cycle|positive regulation of phosphatidylinositol 3-kinase signaling|TORC2 complex|activation of protein kinase B activity|TORC2 signaling hsa04150 mTOR signaling pathway PRR5L 111.9529585 109.6152446 114.2906723 1.042653079 0.060259212 0.940825097 1 1.353724808 1.472265543 79899 proline rich 5 like "GO:0001933,GO:0001934,GO:0005515,GO:0009968,GO:0010762,GO:0014068,GO:0031625,GO:0031932,GO:0034599,GO:0038203,GO:0061014,GO:0090316" negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|protein binding|negative regulation of signal transduction|regulation of fibroblast migration|positive regulation of phosphatidylinositol 3-kinase signaling|ubiquitin protein ligase binding|TORC2 complex|cellular response to oxidative stress|TORC2 signaling|positive regulation of mRNA catabolic process|positive regulation of intracellular protein transport PRR7 509.2057835 695.2448383 323.1667286 0.464824348 -1.105242454 0.00703743 0.341973728 3.862202302 1.872577569 80758 "proline rich 7, synaptic" "GO:0002250,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0010942,GO:0016021,GO:0030425,GO:0031397,GO:0033077,GO:0036041,GO:0043065,GO:0044389,GO:0044877,GO:0046632,GO:0048471,GO:0098839,GO:0098978,GO:0099092,GO:0099527,GO:1990782,GO:2001269" "adaptive immune response|protein binding|nucleoplasm|cytosol|plasma membrane|positive regulation of cell death|integral component of membrane|dendrite|negative regulation of protein ubiquitination|T cell differentiation in thymus|long-chain fatty acid binding|positive regulation of apoptotic process|ubiquitin-like protein ligase binding|protein-containing complex binding|alpha-beta T cell differentiation|perinuclear region of cytoplasm|postsynaptic density membrane|glutamatergic synapse|postsynaptic density, intracellular component|postsynapse to nucleus signaling pathway|protein tyrosine kinase binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway" PRRC1 1470.275306 1567.092015 1373.458597 0.876437748 -0.190276473 0.567635574 1 26.58883826 24.30728014 133619 proline rich coiled-coil 1 "GO:0005515,GO:0005737,GO:0005794,GO:0034199,GO:0034237,GO:0042802" protein binding|cytoplasm|Golgi apparatus|activation of protein kinase A activity|protein kinase A regulatory subunit binding|identical protein binding PRRC2A 7479.730104 6910.835189 8048.625019 1.164638542 0.219882269 0.504008276 1 50.63793726 61.51529265 7916 proline rich coiled-coil 2A "GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0016020,GO:0030154,GO:0070062" RNA binding|protein binding|nucleoplasm|cytosol|plasma membrane|membrane|cell differentiation|extracellular exosome PRRC2B 7700.91776 7146.304973 8255.530546 1.155216658 0.208163451 0.527846881 1 31.96459739 38.51665921 84726 proline rich coiled-coil 2B "GO:0003723,GO:0005515,GO:0030154" RNA binding|protein binding|cell differentiation PRRC2C 8071.065919 8404.850374 7737.281463 0.920573374 -0.11939538 0.718287512 1 39.74194948 38.16133032 23215 proline rich coiled-coil 2C "GO:0002244,GO:0003723,GO:0005829,GO:0008022,GO:0010494,GO:0016020,GO:0030154,GO:0034063" hematopoietic progenitor cell differentiation|RNA binding|cytosol|protein C-terminus binding|cytoplasmic stress granule|membrane|cell differentiation|stress granule assembly PRRG1 407.0448483 413.0870791 401.0026175 0.970745971 -0.042834281 0.926756661 1 3.531038527 3.575394621 5638 proline rich and Gla domain 1 "GO:0005509,GO:0005515,GO:0005576,GO:0005887" calcium ion binding|protein binding|extracellular region|integral component of plasma membrane PRRG2 12.01616809 13.19442759 10.83790858 0.821400437 -0.283842381 0.889026967 1 0.401834763 0.344285208 5639 proline rich and Gla domain 2 "GO:0005509,GO:0005515,GO:0005615,GO:0005886,GO:0005887" calcium ion binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane PRRG4 94.37209992 52.77771036 135.9664895 2.57621046 1.365250457 0.050639189 1 0.467799237 1.257062232 79056 proline rich and Gla domain 4 "GO:0003674,GO:0005509,GO:0005515,GO:0005576,GO:0005886,GO:0008150,GO:0016021,GO:0033116,GO:0050699" molecular_function|calcium ion binding|protein binding|extracellular region|plasma membrane|biological_process|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|WW domain binding PRRT1 24.62888881 33.49354696 15.76423066 0.470664713 -1.087228401 0.303319828 1 0.800155658 0.392827651 80863 proline rich transmembrane protein 1 "GO:0006468,GO:0007611,GO:0016020,GO:0030545,GO:0030672,GO:0034394,GO:0050808,GO:0060291,GO:0060292,GO:0098839,GO:0098978,GO:0099055,GO:2000311" protein phosphorylation|learning or memory|membrane|receptor regulator activity|synaptic vesicle membrane|protein localization to cell surface|synapse organization|long-term synaptic potentiation|long-term synaptic depression|postsynaptic density membrane|glutamatergic synapse|integral component of postsynaptic membrane|regulation of AMPA receptor activity PRRT2 72.2333421 54.80762229 89.65906191 1.635886728 0.710072857 0.349083011 1 1.031517176 1.760133555 112476 proline rich transmembrane protein 2 "GO:0005515,GO:0005886,GO:0008021,GO:0016020,GO:0016021,GO:0017075,GO:0030672,GO:0031629,GO:0031982,GO:0035544,GO:0042734,GO:0043197,GO:0043679,GO:0050884,GO:0098793,GO:0098839,GO:1905513" protein binding|plasma membrane|synaptic vesicle|membrane|integral component of membrane|syntaxin-1 binding|synaptic vesicle membrane|synaptic vesicle fusion to presynaptic active zone membrane|vesicle|negative regulation of SNARE complex assembly|presynaptic membrane|dendritic spine|axon terminus|neuromuscular process controlling posture|presynapse|postsynaptic density membrane|negative regulation of short-term synaptic potentiation PRRT3 307.7194564 324.7859099 290.6530029 0.894906442 -0.160191232 0.73744338 1 3.845980958 3.590051623 285368 proline rich transmembrane protein 3 GO:0016021 integral component of membrane PRRT4 5.985815379 5.074779842 6.896850916 1.359044359 0.442592546 0.890504047 1 0.054430262 0.077159603 401399 proline rich transmembrane protein 4 GO:0016021 integral component of membrane PRRX1 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.059357898 0.012020708 5396 paired related homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001102,GO:0001227,GO:0001228,GO:0002053,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0030326,GO:0042472,GO:0042474,GO:0045880,GO:0045944,GO:0048664,GO:0048701,GO:0048844,GO:0051216,GO:0060021,GO:0070570,GO:0071837,GO:0097150,GO:0100026" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of mesenchymal cell proliferation|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|embryonic limb morphogenesis|inner ear morphogenesis|middle ear morphogenesis|positive regulation of smoothened signaling pathway|positive regulation of transcription by RNA polymerase II|neuron fate determination|embryonic cranial skeleton morphogenesis|artery morphogenesis|cartilage development|roof of mouth development|regulation of neuron projection regeneration|HMG box domain binding|neuronal stem cell population maintenance|positive regulation of DNA repair by transcription from RNA polymerase II promoter" PRSS12 703.6173564 683.0653667 724.1693462 1.060175763 0.084303464 0.826318512 1 6.031180459 6.669543728 8492 serine protease 12 "GO:0004252,GO:0005044,GO:0005886,GO:0006887,GO:0006897,GO:0008236,GO:0030424,GO:0030425,GO:0031410,GO:0031638,GO:0043083,GO:0043195" serine-type endopeptidase activity|scavenger receptor activity|plasma membrane|exocytosis|endocytosis|serine-type peptidase activity|axon|dendrite|cytoplasmic vesicle|zymogen activation|synaptic cleft|terminal bouton PRSS16 70.12920128 45.67301858 94.58538399 2.070924737 1.050275123 0.169765542 1 0.849184018 1.834349382 10279 serine protease 16 "GO:0005764,GO:0005768,GO:0006508,GO:0008236,GO:0008239,GO:0030163" lysosome|endosome|proteolysis|serine-type peptidase activity|dipeptidyl-peptidase activity|protein catabolic process PRSS23 1909.390736 2657.154725 1161.626747 0.437169404 -1.19373566 0.000265459 0.035980283 35.06396898 15.98920102 11098 serine protease 23 "GO:0004252,GO:0005515,GO:0005634,GO:0005788,GO:0006508,GO:0043687,GO:0044267,GO:0070062" serine-type endopeptidase activity|protein binding|nucleus|endoplasmic reticulum lumen|proteolysis|post-translational protein modification|cellular protein metabolic process|extracellular exosome PRSS27 13.56829359 18.26920743 8.867379749 0.485372985 -1.042834281 0.421100961 1 0.618910305 0.313342457 83886 serine protease 27 "GO:0004252,GO:0005576,GO:0006508" serine-type endopeptidase activity|extracellular region|proteolysis PRSS3 569.3029535 560.2556945 578.3502125 1.032296893 0.045857955 0.912187204 1 22.15064361 23.85101686 5646 serine protease 3 "GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0007586,GO:0009235,GO:0019730,GO:0031638,GO:0043312,GO:0043542,GO:1904724" serine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|extracellular space|proteolysis|digestion|cobalamin metabolic process|antimicrobial humoral response|zymogen activation|neutrophil degranulation|endothelial cell migration|tertiary granule lumen "hsa04080,hsa04972,hsa04974,hsa05164" Neuroactive ligand-receptor interaction|Pancreatic secretion|Protein digestion and absorption|Influenza A PRSS35 27.18112451 39.58328277 14.77896625 0.373363835 -1.421345905 0.166061363 1 0.78648632 0.306294608 167681 serine protease 35 "GO:0005515,GO:0005576" protein binding|extracellular region PRSS36 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.018176782 0.073620458 146547 serine protease 36 "GO:0004252,GO:0005576,GO:0005737,GO:0006508" serine-type endopeptidase activity|extracellular region|cytoplasm|proteolysis PRSS53 87.32134804 109.6152446 65.02745149 0.593233649 -0.753327664 0.289268743 1 1.671672821 1.034410661 339105 serine protease 53 "GO:0004252,GO:0005515,GO:0005576,GO:0006508" serine-type endopeptidase activity|protein binding|extracellular region|proteolysis PRTFDC1 230.3546729 222.2753571 238.4339888 1.072696461 0.101241896 0.851604112 1 5.805808507 6.496141628 56952 phosphoribosyl transferase domain containing 1 "GO:0000166,GO:0000287,GO:0004422,GO:0005515,GO:0006166,GO:0006178,GO:0042803,GO:0046038" nucleotide binding|magnesium ion binding|hypoxanthine phosphoribosyltransferase activity|protein binding|purine ribonucleoside salvage|guanine salvage|protein homodimerization activity|GMP catabolic process PRTG 288.435293 286.2175831 290.6530029 1.015496671 0.022185511 0.971027993 1 0.994096205 1.052986613 283659 protogenin "GO:0005615,GO:0005886,GO:0016021,GO:0038023,GO:0042802,GO:0050768" extracellular space|plasma membrane|integral component of membrane|signaling receptor activity|identical protein binding|negative regulation of neurogenesis PRTN3 3.044867905 6.08973581 0 0 #NAME? 0.124110187 1 0.288246388 0 5657 proteinase 3 "GO:0004252,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0006508,GO:0006509,GO:0006909,GO:0007596,GO:0008236,GO:0008284,GO:0019221,GO:0019730,GO:0019899,GO:0030574,GO:0035578,GO:0043231,GO:0043312,GO:0043547,GO:0044853,GO:0045217,GO:0050765,GO:0062023,GO:0070062,GO:0072672,GO:0097029" serine-type endopeptidase activity|signaling receptor binding|protein binding|extracellular region|extracellular space|cytosol|plasma membrane|proteolysis|membrane protein ectodomain proteolysis|phagocytosis|blood coagulation|serine-type peptidase activity|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|antimicrobial humoral response|enzyme binding|collagen catabolic process|azurophil granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|positive regulation of GTPase activity|plasma membrane raft|cell-cell junction maintenance|negative regulation of phagocytosis|collagen-containing extracellular matrix|extracellular exosome|neutrophil extravasation|mature conventional dendritic cell differentiation PRUNE1 445.2150608 429.3263746 461.1037469 1.074016818 0.103016585 0.811051641 1 7.085000424 7.93719212 58497 prune exopolyphosphatase 1 "GO:0004309,GO:0004427,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0006798,GO:0015631,GO:0016311,GO:0016791,GO:0031113,GO:0046872,GO:0050767" exopolyphosphatase activity|inorganic diphosphatase activity|protein binding|nucleus|cytoplasm|cytosol|focal adhesion|polyphosphate catabolic process|tubulin binding|dephosphorylation|phosphatase activity|regulation of microtubule polymerization|metal ion binding|regulation of neurogenesis hsa00230 Purine metabolism PRX 252.825481 175.5873825 330.0635795 1.879768209 0.910554776 0.069269425 1 1.447173554 2.837532521 57716 periaxin "GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0008366,GO:0030054,GO:0032287,GO:0043484" molecular_function|protein binding|nucleus|cytoplasm|plasma membrane|axon ensheathment|cell junction|peripheral nervous system myelin maintenance|regulation of RNA splicing PRXL2A 336.4527064 369.4439725 303.4614403 0.821400437 -0.283842381 0.536117468 1 2.439190964 2.08985744 84293 peroxiredoxin like 2A "GO:0005576,GO:0005737,GO:0016209,GO:0045670,GO:0055114,GO:0098869" extracellular region|cytoplasm|antioxidant activity|regulation of osteoclast differentiation|oxidation-reduction process|cellular oxidant detoxification PRXL2B 961.1437513 876.9219567 1045.365546 1.19208504 0.253487158 0.475635246 1 15.73813023 19.56934557 127281 peroxiredoxin like 2B "GO:0001516,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0016209,GO:0016616,GO:0043209,GO:0047017,GO:0055114,GO:0070062,GO:0098869" "prostaglandin biosynthetic process|protein binding|cytoplasm|endoplasmic reticulum|cytosol|antioxidant activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|myelin sheath|prostaglandin-F synthase activity|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification" hsa00590 Arachidonic acid metabolism PRXL2C 470.2056914 420.1917709 520.2196119 1.238052832 0.308072881 0.459096416 1 7.305606196 9.434336573 195827 peroxiredoxin like 2C "GO:0016209,GO:0045821,GO:0055114,GO:0070374,GO:0098869" antioxidant activity|positive regulation of glycolytic process|oxidation-reduction process|positive regulation of ERK1 and ERK2 cascade|cellular oxidant detoxification PSAP 36211.60015 36217.68878 36205.51151 0.999663776 -0.00048515 0.999116827 1 665.3239638 693.7500879 5660 prosaposin "GO:0002020,GO:0002576,GO:0004565,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005764,GO:0005765,GO:0005770,GO:0005886,GO:0006687,GO:0006869,GO:0007041,GO:0007186,GO:0007193,GO:0008047,GO:0008289,GO:0010506,GO:0019216,GO:0035577,GO:0042803,GO:0043202,GO:0043231,GO:0043312,GO:0050790,GO:0060736,GO:0060742,GO:0062023,GO:0070062,GO:1905572,GO:1905573,GO:1905574,GO:1905575,GO:1905576,GO:1905577" protease binding|platelet degranulation|beta-galactosidase activity|protein binding|phospholipid binding|extracellular region|extracellular space|lysosome|lysosomal membrane|late endosome|plasma membrane|glycosphingolipid metabolic process|lipid transport|lysosomal transport|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|enzyme activator activity|lipid binding|regulation of autophagy|regulation of lipid metabolic process|azurophil granule membrane|protein homodimerization activity|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of catalytic activity|prostate gland growth|epithelial cell differentiation involved in prostate gland development|collagen-containing extracellular matrix|extracellular exosome|ganglioside GM1 transport to membrane|ganglioside GM1 binding|ganglioside GM2 binding|ganglioside GM3 binding|ganglioside GT1b binding|ganglioside GP1c binding "hsa00600,hsa04142" Sphingolipid metabolism|Lysosome PSAT1 1770.180441 1424.99818 2115.362702 1.484466951 0.569944974 0.080450379 1 32.71583441 50.65758295 29968 phosphoserine aminotransferase 1 "GO:0004648,GO:0005515,GO:0005737,GO:0005829,GO:0006564,GO:0008615,GO:0030170,GO:0042802,GO:0070062" O-phospho-L-serine:2-oxoglutarate aminotransferase activity|protein binding|cytoplasm|cytosol|L-serine biosynthetic process|pyridoxine biosynthetic process|pyridoxal phosphate binding|identical protein binding|extracellular exosome "hsa00260,hsa00270,hsa00750" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Vitamin B6 metabolism" PSCA 12.50880029 13.19442759 11.823173 0.896073204 -0.158311499 0.970376506 1 0.680500214 0.63604477 8000 prostate stem cell antigen "GO:0005576,GO:0005886,GO:0031225,GO:0033130,GO:0070062,GO:0070373,GO:0099601" extracellular region|plasma membrane|anchored component of membrane|acetylcholine receptor binding|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|regulation of neurotransmitter receptor activity PSD 24.03233617 26.38885518 21.67581716 0.821400437 -0.283842381 0.820256143 1 0.325817265 0.279154705 5662 pleckstrin and Sec7 domain containing "GO:0005085,GO:0005515,GO:0005543,GO:0007165,GO:0031175,GO:0032012,GO:0032154,GO:0032587,GO:0043197,GO:0050790,GO:0098999,GO:0099092" "guanyl-nucleotide exchange factor activity|protein binding|phospholipid binding|signal transduction|neuron projection development|regulation of ARF protein signal transduction|cleavage furrow|ruffle membrane|dendritic spine|regulation of catalytic activity|extrinsic component of postsynaptic endosome membrane|postsynaptic density, intracellular component" hsa04144 Endocytosis PSD2 2.463161041 0 4.926322083 Inf Inf 0.189235799 1 0 0.037483554 84249 pleckstrin and Sec7 domain containing 2 "GO:0005543,GO:0016021,GO:0030425,GO:0032012,GO:0032154,GO:0032587,GO:0043025,GO:0098794,GO:0098978" phospholipid binding|integral component of membrane|dendrite|regulation of ARF protein signal transduction|cleavage furrow|ruffle membrane|neuronal cell body|postsynapse|glutamatergic synapse hsa04144 Endocytosis PSD3 1340.201352 1801.546844 878.8558596 0.487834031 -1.035537691 0.002274149 0.152593148 4.272628994 2.174118475 23362 pleckstrin and Sec7 domain containing 3 "GO:0014069,GO:0032012,GO:0032587,GO:0050790" postsynaptic density|regulation of ARF protein signal transduction|ruffle membrane|regulation of catalytic activity hsa04144 Endocytosis PSD4 230.4828417 298.3970547 162.5686287 0.544806412 -0.876184412 0.089501311 1 2.842346838 1.615233122 23550 pleckstrin and Sec7 domain containing 4 "GO:0005085,GO:0005543,GO:0016020,GO:0032012,GO:0032154,GO:0032587,GO:0050790" guanyl-nucleotide exchange factor activity|phospholipid binding|membrane|regulation of ARF protein signal transduction|cleavage furrow|ruffle membrane|regulation of catalytic activity hsa04144 Endocytosis PSEN1 2082.213337 1943.640679 2220.785995 1.142590819 0.192308842 0.550014837 1 30.42922524 36.26582442 5663 presenilin 1 "GO:0000045,GO:0000122,GO:0000139,GO:0000186,GO:0000776,GO:0001568,GO:0001708,GO:0001756,GO:0001764,GO:0001921,GO:0001947,GO:0002038,GO:0002244,GO:0002265,GO:0002286,GO:0003407,GO:0004175,GO:0004190,GO:0005262,GO:0005515,GO:0005634,GO:0005640,GO:0005654,GO:0005739,GO:0005743,GO:0005765,GO:0005783,GO:0005789,GO:0005790,GO:0005791,GO:0005794,GO:0005813,GO:0005886,GO:0005887,GO:0005938,GO:0006486,GO:0006509,GO:0006816,GO:0006839,GO:0006974,GO:0006979,GO:0007175,GO:0007220,GO:0007611,GO:0007613,GO:0008013,GO:0008021,GO:0009791,GO:0009986,GO:0010468,GO:0010628,GO:0010629,GO:0010975,GO:0015031,GO:0015871,GO:0016020,GO:0016021,GO:0016080,GO:0016235,GO:0016324,GO:0016485,GO:0021549,GO:0021795,GO:0021870,GO:0021904,GO:0030018,GO:0030054,GO:0030165,GO:0030326,GO:0030426,GO:0031293,GO:0031594,GO:0031901,GO:0031965,GO:0032092,GO:0032436,GO:0032469,GO:0032760,GO:0032991,GO:0034205,GO:0035253,GO:0035333,GO:0035556,GO:0035577,GO:0042307,GO:0042325,GO:0042327,GO:0042383,GO:0042500,GO:0042982,GO:0042987,GO:0043005,GO:0043011,GO:0043025,GO:0043065,GO:0043066,GO:0043085,GO:0043198,GO:0043312,GO:0043406,GO:0043524,GO:0043589,GO:0045121,GO:0045296,GO:0045821,GO:0045893,GO:0048013,GO:0048143,GO:0048167,GO:0048471,GO:0048538,GO:0048666,GO:0048705,GO:0048854,GO:0050435,GO:0050673,GO:0050771,GO:0050808,GO:0050820,GO:0050852,GO:0051117,GO:0051208,GO:0051402,GO:0051444,GO:0051563,GO:0051966,GO:0060075,GO:0060828,GO:0060999,GO:0070588,GO:0070765,GO:0070851,GO:0090647,GO:0098609,GO:0098712,GO:0099056,GO:1904646,GO:1904797,GO:1905598,GO:1905908,GO:1990535,GO:2000059,GO:2001234" "autophagosome assembly|negative regulation of transcription by RNA polymerase II|Golgi membrane|activation of MAPKK activity|kinetochore|blood vessel development|cell fate specification|somitogenesis|neuron migration|positive regulation of receptor recycling|heart looping|positive regulation of L-glutamate import across plasma membrane|hematopoietic progenitor cell differentiation|astrocyte activation involved in immune response|T cell activation involved in immune response|neural retina development|endopeptidase activity|aspartic-type endopeptidase activity|calcium channel activity|protein binding|nucleus|nuclear outer membrane|nucleoplasm|mitochondrion|mitochondrial inner membrane|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|smooth endoplasmic reticulum|rough endoplasmic reticulum|Golgi apparatus|centrosome|plasma membrane|integral component of plasma membrane|cell cortex|protein glycosylation|membrane protein ectodomain proteolysis|calcium ion transport|mitochondrial transport|cellular response to DNA damage stimulus|response to oxidative stress|negative regulation of epidermal growth factor-activated receptor activity|Notch receptor processing|learning or memory|memory|beta-catenin binding|synaptic vesicle|post-embryonic development|cell surface|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|regulation of neuron projection development|protein transport|choline transport|membrane|integral component of membrane|synaptic vesicle targeting|aggresome|apical plasma membrane|protein processing|cerebellum development|cerebral cortex cell migration|Cajal-Retzius cell differentiation|dorsal/ventral neural tube patterning|Z disc|cell junction|PDZ domain binding|embryonic limb morphogenesis|growth cone|membrane protein intracellular domain proteolysis|neuromuscular junction|early endosome membrane|nuclear membrane|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|endoplasmic reticulum calcium ion homeostasis|positive regulation of tumor necrosis factor production|protein-containing complex|amyloid-beta formation|ciliary rootlet|Notch receptor processing, ligand-dependent|intracellular signal transduction|azurophil granule membrane|positive regulation of protein import into nucleus|regulation of phosphorylation|positive regulation of phosphorylation|sarcolemma|aspartic endopeptidase activity, intramembrane cleaving|amyloid precursor protein metabolic process|amyloid precursor protein catabolic process|neuron projection|myeloid dendritic cell differentiation|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of catalytic activity|dendritic shaft|neutrophil degranulation|positive regulation of MAP kinase activity|negative regulation of neuron apoptotic process|skin morphogenesis|membrane raft|cadherin binding|positive regulation of glycolytic process|positive regulation of transcription, DNA-templated|ephrin receptor signaling pathway|astrocyte activation|regulation of synaptic plasticity|perinuclear region of cytoplasm|thymus development|neuron development|skeletal system morphogenesis|brain morphogenesis|amyloid-beta metabolic process|epithelial cell proliferation|negative regulation of axonogenesis|synapse organization|positive regulation of coagulation|T cell receptor signaling pathway|ATPase binding|sequestering of calcium ion|neuron apoptotic process|negative regulation of ubiquitin-protein transferase activity|smooth endoplasmic reticulum calcium ion homeostasis|regulation of synaptic transmission, glutamatergic|regulation of resting membrane potential|regulation of canonical Wnt signaling pathway|positive regulation of dendritic spine development|calcium ion transmembrane transport|gamma-secretase complex|growth factor receptor binding|modulation of age-related behavioral decline|cell-cell adhesion|L-glutamate import across plasma membrane|integral component of presynaptic membrane|cellular response to amyloid-beta|negative regulation of core promoter binding|negative regulation of low-density lipoprotein receptor activity|positive regulation of amyloid fibril formation|neuron projection maintenance|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of apoptotic signaling pathway" "hsa04310,hsa04330,hsa04722,hsa05010,hsa05022,hsa05165" Wnt signaling pathway|Notch signaling pathway|Neurotrophin signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection PSEN2 285.2392457 303.4718345 267.0066569 0.879839993 -0.184686914 0.705222696 1 5.793357646 5.316795652 5664 presenilin 2 "GO:0000139,GO:0000776,GO:0004175,GO:0005515,GO:0005634,GO:0005637,GO:0005743,GO:0005765,GO:0005783,GO:0005789,GO:0005794,GO:0005813,GO:0005886,GO:0005887,GO:0005938,GO:0006509,GO:0006816,GO:0007220,GO:0009986,GO:0016020,GO:0016324,GO:0016485,GO:0030018,GO:0030426,GO:0031293,GO:0031594,GO:0032991,GO:0034205,GO:0035253,GO:0035333,GO:0035556,GO:0042500,GO:0042987,GO:0043025,GO:0043065,GO:0043066,GO:0043085,GO:0043198,GO:0045121,GO:0048013,GO:0048471,GO:0050435,GO:0070765,GO:0110097,GO:1990456" "Golgi membrane|kinetochore|endopeptidase activity|protein binding|nucleus|nuclear inner membrane|mitochondrial inner membrane|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|centrosome|plasma membrane|integral component of plasma membrane|cell cortex|membrane protein ectodomain proteolysis|calcium ion transport|Notch receptor processing|cell surface|membrane|apical plasma membrane|protein processing|Z disc|growth cone|membrane protein intracellular domain proteolysis|neuromuscular junction|protein-containing complex|amyloid-beta formation|ciliary rootlet|Notch receptor processing, ligand-dependent|intracellular signal transduction|aspartic endopeptidase activity, intramembrane cleaving|amyloid precursor protein catabolic process|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of catalytic activity|dendritic shaft|membrane raft|ephrin receptor signaling pathway|perinuclear region of cytoplasm|amyloid-beta metabolic process|gamma-secretase complex|regulation of calcium import into the mitochondrion|mitochondrion-endoplasmic reticulum membrane tethering" "hsa04330,hsa04722,hsa05010,hsa05022" Notch signaling pathway|Neurotrophin signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases PSENEN 609.9336054 609.988537 609.8786738 0.999819893 -0.000259863 1 1 27.48555826 28.66436106 55851 "presenilin enhancer, gamma-secretase subunit" "GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0006509,GO:0007220,GO:0010008,GO:0010950,GO:0016021,GO:0016485,GO:0019899,GO:0031293,GO:0032580,GO:0034205,GO:0035333,GO:0042982,GO:0042987,GO:0043065,GO:0043085,GO:0044267,GO:0048013,GO:0061133,GO:0070765" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|membrane protein ectodomain proteolysis|Notch receptor processing|endosome membrane|positive regulation of endopeptidase activity|integral component of membrane|protein processing|enzyme binding|membrane protein intracellular domain proteolysis|Golgi cisterna membrane|amyloid-beta formation|Notch receptor processing, ligand-dependent|amyloid precursor protein metabolic process|amyloid precursor protein catabolic process|positive regulation of apoptotic process|positive regulation of catalytic activity|cellular protein metabolic process|ephrin receptor signaling pathway|endopeptidase activator activity|gamma-secretase complex" "hsa04330,hsa05010" Notch signaling pathway|Alzheimer disease PSG1 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.052116194 0.017590289 5669 pregnancy specific beta-1-glycoprotein 1 "GO:0005515,GO:0005576,GO:0007565,GO:0050900" protein binding|extracellular region|female pregnancy|leukocyte migration PSG4 52.12449622 60.8973581 43.35163433 0.711880378 -0.490293258 0.566928029 1 1.052640394 0.781633175 5672 pregnancy specific beta-1-glycoprotein 4 "GO:0005576,GO:0007565" extracellular region|female pregnancy PSG9 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.063666013 0.051572617 5678 pregnancy specific beta-1-glycoprotein 9 "GO:0005576,GO:0007565" extracellular region|female pregnancy PSIP1 1811.686994 1534.613424 2088.760563 1.361098848 0.444771844 0.171189896 1 14.70907573 20.88290822 11168 PC4 and SFRS1 interacting protein 1 "GO:0000395,GO:0003690,GO:0003712,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006979,GO:0009408,GO:0035327,GO:0051169,GO:0075713,GO:0097100" mRNA 5'-splice site recognition|double-stranded DNA binding|transcription coregulator activity|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|response to oxidative stress|response to heat|transcriptionally active chromatin|nuclear transport|establishment of integrated proviral latency|supercoiled DNA binding PSKH1 825.490507 696.2597943 954.7212196 1.37121406 0.455453808 0.212395614 1 10.08381536 14.42268348 5681 protein serine kinase H1 "GO:0005515,GO:0005524,GO:0005789,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0006468,GO:0007368,GO:0007507,GO:0016607,GO:0106310,GO:0106311" protein binding|ATP binding|endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|protein phosphorylation|determination of left/right symmetry|heart development|nuclear speck|protein serine kinase activity|protein threonine kinase activity PSMA1 2868.350921 3216.395464 2520.306378 0.783581001 -0.351845677 0.269138265 1 78.24163472 63.94958682 5682 proteasome 20S subunit alpha 1 "GO:0000165,GO:0000209,GO:0000502,GO:0001530,GO:0002223,GO:0002479,GO:0002862,GO:0003723,GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005839,GO:0005844,GO:0006521,GO:0010499,GO:0010972,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|lipopolysaccharide binding|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|negative regulation of inflammatory response to antigenic stimulus|RNA binding|endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|proteasome core complex|polysome|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA2 2171.488884 2254.217206 2088.760563 0.926601287 -0.109979409 0.732440587 1 79.61516672 76.94929363 5683 proteasome 20S subunit alpha 2 "GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0009615,GO:0010499,GO:0010972,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|P-body|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|response to virus|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA3 1537.883201 1777.187901 1298.578501 0.730692855 -0.452662995 0.171045778 1 94.24952631 71.83398614 5684 proteasome 20S subunit alpha 3 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0031625,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045202,GO:0050852,GO:0052548,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|ubiquitin protein ligase binding|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|synapse|T cell receptor signaling pathway|regulation of endopeptidase activity|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA4 3269.55173 3533.061726 3006.041735 0.850831932 -0.233053915 0.463845308 1 40.05755821 35.55037474 5685 proteasome 20S subunit alpha 4 "GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043231,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|P-body|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA5 2229.059305 2350.638023 2107.480587 0.896556835 -0.157533052 0.623294628 1 31.206166 29.18328458 5686 proteasome 20S subunit alpha 5 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA6 2674.783081 2949.462044 2400.104119 0.813743009 -0.297354851 0.350792552 1 53.31186562 45.25088536 5687 proteasome 20S subunit alpha 6 "GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0002223,GO:0002479,GO:0003723,GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0005844,GO:0006521,GO:0010499,GO:0010972,GO:0016363,GO:0016579,GO:0019773,GO:0030016,GO:0030017,GO:0031145,GO:0031146,GO:0033209,GO:0035639,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050727,GO:0050852,GO:0051059,GO:0051092,GO:0051603,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|P-body|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|RNA binding|endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|polysome|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|nuclear matrix|protein deubiquitination|proteasome core complex, alpha-subunit complex|myofibril|sarcomere|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|purine ribonucleoside triphosphate binding|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|regulation of inflammatory response|T cell receptor signaling pathway|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|proteolysis involved in cellular protein catabolic process|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA7 5872.602766 7607.094983 4138.110549 0.543980397 -0.878373432 0.007066079 0.341973728 400.4911899 227.243854 5688 proteasome 20S subunit alpha 7 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:0098794,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|postsynapse|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB1 1866.660395 1992.358566 1740.962224 0.87381973 -0.194592414 0.548535388 1 113.2502051 103.2230704 5689 proteasome 20S subunit beta 1 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB10 277.4368025 241.5595205 313.3140845 1.297047137 0.375230911 0.440475491 1 12.52214692 16.94144632 5699 proteasome 20S subunit beta 10 "GO:0000165,GO:0000209,GO:0000502,GO:0000902,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0006959,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0042098,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1990111" "MAPK cascade|protein polyubiquitination|proteasome complex|cell morphogenesis|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|humoral immune response|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|T cell proliferation|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex" hsa03050 Proteasome PSMB2 2684.050059 2808.383164 2559.716954 0.91145574 -0.133755494 0.675137026 1 31.41225705 29.86418426 5690 proteasome 20S subunit beta 2 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010243,GO:0010499,GO:0010972,GO:0014070,GO:0016020,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|response to organonitrogen compound|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|response to organic cyclic compound|membrane|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB3 2739.308498 2881.459994 2597.157002 0.901333701 -0.14986676 0.638393147 1 191.5167763 180.056317 5691 proteasome 20S subunit beta 3 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB4 4862.411546 4993.583364 4731.239728 0.947463852 -0.077857193 0.808609574 1 275.4982365 272.2685023 5692 proteasome 20S subunit beta 4 "GO:0000165,GO:0000209,GO:0000502,GO:0001530,GO:0002223,GO:0002479,GO:0002862,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0036064,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|lipopolysaccharide binding|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|negative regulation of inflammatory response to antigenic stimulus|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|ciliary basal body|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB5 2741.231768 2911.908673 2570.554863 0.882773174 -0.179885305 0.572510637 1 118.6467431 109.2498573 5693 proteasome 20S subunit beta 5 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005839,GO:0006508,GO:0006521,GO:0006979,GO:0008233,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|proteasome core complex|proteolysis|regulation of cellular amino acid metabolic process|response to oxidative stress|peptidase activity|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB6 2034.597997 2056.300792 2012.895203 0.97889142 -0.030779251 0.925341462 1 123.3938163 125.9922547 5694 proteasome 20S subunit beta 6 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045296,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|cadherin binding|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB7 3108.94299 3296.576985 2921.308995 0.886164348 -0.174353809 0.583877457 1 169.6747913 156.8366391 5695 proteasome 20S subunit beta 7 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0016604,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|nuclear body|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB8 572.751379 560.2556945 585.2470634 1.044607077 0.062960383 0.877557225 1 18.60654063 20.27377065 5696 proteasome 20S subunit beta 8 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045444,GO:0050852,GO:0052548,GO:0055085,GO:0060071,GO:0060337,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1990111" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|fat cell differentiation|T cell receptor signaling pathway|regulation of endopeptidase activity|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|type I interferon signaling pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex" hsa03050 Proteasome PSMB9 209.9637573 209.0809295 210.8465851 1.008444843 0.012132178 0.991976349 1 10.41220402 10.95243661 5698 proteasome 20S subunit beta 9 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1990111,GO:2000116" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex|regulation of cysteine-type endopeptidase activity" hsa03050 Proteasome PSMC1 2128.307235 2366.877318 1889.737151 0.798409422 -0.324799349 0.3117136 1 20.143503 16.77554276 5700 "proteasome 26S subunit, ATPase 1" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006457,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0016887,GO:0017025,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0036402,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901215,GO:1901800,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|protein folding|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|ATPase activity|TBP-class protein binding|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|proteasome-activating ATPase activity|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of neuron death|positive regulation of proteasomal protein catabolic process|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05165,hsa05169,hsa05203" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Epstein-Barr virus infection|Viral carcinogenesis PSMC2 1910.60982 2167.945948 1653.273691 0.762599129 -0.391003212 0.226753233 1 38.78446282 30.85105465 5701 "proteasome 26S subunit, ATPase 2" "GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0001649,GO:0002223,GO:0002479,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0016887,GO:0017025,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0036402,GO:0036464,GO:0038061,GO:0038095,GO:0043161,GO:0043197,GO:0043312,GO:0043488,GO:0043687,GO:0045899,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901800,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|P-body|osteoblast differentiation|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|ATPase activity|TBP-class protein binding|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|proteasome-activating ATPase activity|cytoplasmic ribonucleoprotein granule|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|dendritic spine|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|positive regulation of RNA polymerase II transcription preinitiation complex assembly|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of proteasomal protein catabolic process|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMC3 3285.857336 3300.636809 3271.077863 0.991044472 -0.012978297 0.968484053 1 108.5490977 112.2109633 5702 "proteasome 26S subunit, ATPase 3" "GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0002223,GO:0002479,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016032,GO:0016579,GO:0016887,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0036402,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0043921,GO:0045899,GO:0045944,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901800,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|P-body|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|viral process|protein deubiquitination|ATPase activity|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|proteasome-activating ATPase activity|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|modulation by host of viral transcription|positive regulation of RNA polymerase II transcription preinitiation complex assembly|positive regulation of transcription by RNA polymerase II|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of proteasomal protein catabolic process|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMC3IP 664.6684827 512.552764 816.7842013 1.593561207 0.672254433 0.078929815 1 16.24467417 27.00198449 29893 PSMC3 interacting protein "GO:0003677,GO:0005654,GO:0007131,GO:0030374,GO:0045893" "DNA binding|nucleoplasm|reciprocal meiotic recombination|nuclear receptor coactivator activity|positive regulation of transcription, DNA-templated" PSMC4 1740.240232 1904.057397 1576.423066 0.827928333 -0.272422204 0.403644684 1 54.97935578 47.47973884 5704 "proteasome 26S subunit, ATPase 4" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006508,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016234,GO:0016579,GO:0016887,GO:0022624,GO:0031145,GO:0031146,GO:0031597,GO:0033209,GO:0036402,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045202,GO:0045899,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901800,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|proteolysis|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|inclusion body|protein deubiquitination|ATPase activity|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|proteasome-activating ATPase activity|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|synapse|positive regulation of RNA polymerase II transcription preinitiation complex assembly|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of proteasomal protein catabolic process|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMC5 3005.73048 3279.322734 2732.138227 0.833141002 -0.263367415 0.407892451 1 105.7200049 91.87378578 5705 "proteasome 26S subunit, ATPase 5" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006521,GO:0008134,GO:0008540,GO:0010972,GO:0016020,GO:0016234,GO:0016579,GO:0016887,GO:0017025,GO:0022624,GO:0031145,GO:0031146,GO:0031410,GO:0031531,GO:0031595,GO:0031597,GO:0033209,GO:0038061,GO:0038095,GO:0043069,GO:0043161,GO:0043488,GO:0043687,GO:0045892,GO:0045893,GO:0045899,GO:0050804,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0072562,GO:0090090,GO:0090261,GO:0090263,GO:0098794,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|regulation of cellular amino acid metabolic process|transcription factor binding|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|inclusion body|protein deubiquitination|ATPase activity|TBP-class protein binding|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cytoplasmic vesicle|thyrotropin-releasing hormone receptor binding|nuclear proteasome complex|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|negative regulation of programmed cell death|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of RNA polymerase II transcription preinitiation complex assembly|modulation of chemical synaptic transmission|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|blood microparticle|negative regulation of canonical Wnt signaling pathway|positive regulation of inclusion body assembly|positive regulation of canonical Wnt signaling pathway|postsynapse|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMC6 1273.781365 1302.188507 1245.374223 0.956370153 -0.064358988 0.851414394 1 17.87781351 17.83431145 5706 "proteasome 26S subunit, ATPase 6" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0016887,GO:0022624,GO:0030433,GO:0030674,GO:0031145,GO:0031146,GO:0031597,GO:0033209,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0045899,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|ATPase activity|proteasome accessory complex|ubiquitin-dependent ERAD pathway|protein-macromolecule adaptor activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|positive regulation of RNA polymerase II transcription preinitiation complex assembly|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD1 2982.819742 3228.574935 2737.064549 0.847762435 -0.238268054 0.454072287 1 37.7634944 33.39352558 5707 "proteasome 26S subunit, non-ATPase 1" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0031625,GO:0033209,GO:0034515,GO:0035578,GO:0038061,GO:0038095,GO:0042176,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050790,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|ubiquitin protein ligase binding|tumor necrosis factor-mediated signaling pathway|proteasome storage granule|azurophil granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|regulation of protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|regulation of catalytic activity|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD10 1144.342066 1074.838371 1213.845761 1.129328646 0.175465385 0.611666583 1 37.03181746 43.6225753 5716 "proteasome 26S subunit, non-ATPase 10" "GO:0000122,GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0006915,GO:0007253,GO:0008134,GO:0008540,GO:0010972,GO:0016579,GO:0030307,GO:0031145,GO:0031146,GO:0031398,GO:0032088,GO:0032436,GO:0033209,GO:0038061,GO:0038095,GO:0043066,GO:0043161,GO:0043409,GO:0043488,GO:0043518,GO:0043687,GO:0045111,GO:0045737,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070682,GO:0090090,GO:0090201,GO:0090263,GO:1901990,GO:1902036" "negative regulation of transcription by RNA polymerase II|MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|apoptotic process|cytoplasmic sequestering of NF-kappaB|transcription factor binding|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|positive regulation of cell growth|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of MAPK cascade|regulation of mRNA stability|negative regulation of DNA damage response, signal transduction by p53 class mediator|post-translational protein modification|intermediate filament cytoskeleton|positive regulation of cyclin-dependent protein serine/threonine kinase activity|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome regulatory particle assembly|negative regulation of canonical Wnt signaling pathway|negative regulation of release of cytochrome c from mitochondria|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" PSMD11 2591.640323 2856.086095 2327.194552 0.814819468 -0.295447645 0.354179191 1 37.57160651 31.93280667 5717 "proteasome 26S subunit, non-ATPase 11" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005198,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006521,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043248,GO:0043312,GO:0043488,GO:0043687,GO:0048863,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|structural molecule activity|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|stem cell differentiation|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD12 1818.660549 1876.653586 1760.667512 0.938195267 -0.092039872 0.778010746 1 19.3379214 18.92426227 5718 "proteasome 26S subunit, non-ATPase 12" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005576,GO:0005654,GO:0005737,GO:0005829,GO:0005838,GO:0006521,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0031595,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|extracellular region|nucleoplasm|cytoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|nuclear proteasome complex|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD13 2202.775608 2473.447695 1932.103521 0.781137812 -0.356350997 0.266204566 1 74.65518471 60.82800389 5719 "proteasome 26S subunit, non-ATPase 13" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005198,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006511,GO:0006521,GO:0007127,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043248,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|structural molecule activity|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|meiosis I|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD14 1295.386913 1432.102871 1158.670954 0.809069639 -0.305664209 0.366233357 1 46.28650816 39.06215987 10213 "proteasome 26S subunit, non-ATPase 14" "GO:0000165,GO:0000209,GO:0000502,GO:0000724,GO:0002223,GO:0002479,GO:0004843,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006303,GO:0006511,GO:0006521,GO:0008237,GO:0008541,GO:0010950,GO:0010972,GO:0016579,GO:0018215,GO:0022624,GO:0031145,GO:0031146,GO:0031597,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0045471,GO:0046872,GO:0050852,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0061578,GO:0070122,GO:0070498,GO:0070536,GO:0070628,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|double-strand break repair via homologous recombination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|thiol-dependent ubiquitin-specific protease activity|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|metallopeptidase activity|proteasome regulatory particle, lid subcomplex|positive regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|protein phosphopantetheinylation|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|response to ethanol|metal ion binding|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|Lys63-specific deubiquitinase activity|isopeptidase activity|interleukin-1-mediated signaling pathway|protein K63-linked deubiquitination|proteasome binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD2 12171.89281 12726.53289 11617.25274 0.912837207 -0.131570498 0.701026061 1 213.5699119 203.3524138 5708 "proteasome 26S subunit, non-ATPase 2" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0033209,GO:0034515,GO:0034774,GO:0038061,GO:0038095,GO:0042176,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050790,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|proteasome storage granule|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|regulation of protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|regulation of catalytic activity|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD3 3459.875026 3679.215385 3240.534666 0.880767861 -0.183166268 0.564971418 1 86.79053553 79.73513923 5709 "proteasome 26S subunit, non-ATPase 3" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006521,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0042176,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050790,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|regulation of protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|regulation of catalytic activity|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD4 3058.509675 3182.901917 2934.117432 0.921837213 -0.117416087 0.712573051 1 123.1495443 118.413979 5710 "proteasome 26S subunit, non-ATPase 4" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006521,GO:0008540,GO:0010972,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0031593,GO:0033209,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043248,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|polyubiquitin modification-dependent protein binding|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD5 1233.053474 1346.84657 1119.260377 0.831022926 -0.267039817 0.433414005 1 20.17539999 17.48844069 5711 "proteasome 26S subunit, non-ATPase 5" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005654,GO:0005829,GO:0006521,GO:0008540,GO:0010972,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070682,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome regulatory particle assembly|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" PSMD6 1832.944161 1910.147132 1755.74119 0.919165419 -0.121603572 0.708777441 1 57.75654547 55.3746273 9861 "proteasome 26S subunit, non-ATPase 6" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005576,GO:0005654,GO:0005829,GO:0005838,GO:0006508,GO:0006521,GO:0010972,GO:0016579,GO:0016887,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050790,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|extracellular region|nucleoplasm|cytosol|proteasome regulatory particle|proteolysis|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|ATPase activity|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|regulation of catalytic activity|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD7 1604.893305 1811.696404 1398.090207 0.771702259 -0.373883766 0.255727139 1 56.25753008 45.28416481 5713 "proteasome 26S subunit, non-ATPase 7" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008237,GO:0010972,GO:0016020,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0042803,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070122,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|metallopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|isopeptidase activity|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD8 2830.213367 2798.233605 2862.19313 1.022857107 0.032604615 0.919504021 1 93.36011891 99.60755802 5714 "proteasome 26S subunit, non-ATPase 8" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008541,GO:0010972,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD9 1051.777191 1010.896145 1092.658238 1.080880805 0.112207437 0.749905659 1 18.78837559 21.18278057 5715 "proteasome 26S subunit, non-ATPase 9" "GO:0000165,GO:0000209,GO:0002223,GO:0002479,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005838,GO:0006511,GO:0006521,GO:0008540,GO:0010972,GO:0016579,GO:0031145,GO:0031146,GO:0032024,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043425,GO:0043488,GO:0043687,GO:0045893,GO:0046676,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070682,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome regulatory particle|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of insulin secretion|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|bHLH transcription factor binding|regulation of mRNA stability|post-translational protein modification|positive regulation of transcription, DNA-templated|negative regulation of insulin secretion|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome regulatory particle assembly|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSME1 2178.358765 2218.693747 2138.023784 0.963640785 -0.05343264 0.868880918 1 116.4445712 117.0443215 5720 proteasome activator subunit 1 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0008537,GO:0010950,GO:0010972,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:2000045" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome activator complex|positive regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|regulation of G1/S transition of mitotic cell cycle" "hsa03050,hsa04612" Proteasome|Antigen processing and presentation PSME2 1725.955381 1702.081159 1749.829604 1.028052978 0.039914612 0.904357294 1 108.7066912 116.5702431 5721 proteasome activator subunit 2 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0008537,GO:0010950,GO:0010972,GO:0016020,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0035722,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:2000045" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome activator complex|positive regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|interleukin-12-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|regulation of G1/S transition of mitotic cell cycle" "hsa03050,hsa04612" Proteasome|Antigen processing and presentation PSME3 4614.274855 4801.756686 4426.793024 0.921911149 -0.11730038 0.714285231 1 68.54341505 65.91294787 10197 proteasome activator subunit 3 "GO:0000165,GO:0000209,GO:0000502,GO:0002039,GO:0002223,GO:0002479,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0006915,GO:0007049,GO:0008537,GO:0010950,GO:0010972,GO:0016020,GO:0016032,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:0097371,GO:1901990,GO:1902036,GO:2000045,GO:2001237" "MAPK cascade|protein polyubiquitination|proteasome complex|p53 binding|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|apoptotic process|cell cycle|proteasome activator complex|positive regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|membrane|viral process|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|MDM2/MDM4 family protein binding|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|regulation of G1/S transition of mitotic cell cycle|negative regulation of extrinsic apoptotic signaling pathway" "hsa03050,hsa04612,hsa05160" Proteasome|Antigen processing and presentation|Hepatitis C PSME3IP1 1162.175303 1148.930156 1175.420449 1.023056487 0.032885804 0.926320371 1 8.916527617 9.51505498 80011 proteasome activator subunit 3 interacting protein 1 "GO:0005515,GO:0005634,GO:0032091,GO:1901799" protein binding|nucleus|negative regulation of protein binding|negative regulation of proteasomal protein catabolic process PSME4 1542.047191 1421.953312 1662.141071 1.168913956 0.225168737 0.495997952 1 10.01069209 12.20569679 23198 proteasome activator subunit 4 "GO:0000165,GO:0000209,GO:0002223,GO:0002479,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006521,GO:0006974,GO:0007275,GO:0010499,GO:0010952,GO:0010972,GO:0016504,GO:0016579,GO:0016607,GO:0031145,GO:0031146,GO:0033209,GO:0035093,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070577,GO:0070628,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1990111" "MAPK cascade|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|regulation of cellular amino acid metabolic process|cellular response to DNA damage stimulus|multicellular organism development|proteasomal ubiquitin-independent protein catabolic process|positive regulation of peptidase activity|negative regulation of G2/M transition of mitotic cell cycle|peptidase activator activity|protein deubiquitination|nuclear speck|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|spermatogenesis, exchange of chromosomal proteins|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|lysine-acetylated histone binding|proteasome binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex" hsa03050 Proteasome PSMF1 3575.298182 3520.882254 3629.714111 1.030910394 0.04391894 0.891006113 1 21.48178114 23.09974233 9491 proteasome inhibitor subunit 1 "GO:0000165,GO:0000209,GO:0002223,GO:0002479,GO:0004866,GO:0005515,GO:0005654,GO:0005783,GO:0005829,GO:0005839,GO:0006511,GO:0006521,GO:0010951,GO:0010972,GO:0016020,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0042803,GO:0043161,GO:0043488,GO:0043687,GO:0046982,GO:0048471,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070628,GO:0090090,GO:0090263,GO:1901799,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase inhibitor activity|protein binding|nucleoplasm|endoplasmic reticulum|cytosol|proteasome core complex|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|negative regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|protein heterodimerization activity|perinuclear region of cytoplasm|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of proteasomal protein catabolic process|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" hsa03050 Proteasome PSMG1 684.0011428 689.1551025 678.847183 0.985042671 -0.021741873 0.958474295 1 17.21068775 17.68353959 8624 proteasome assembly chaperone 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005794,GO:0005829,GO:0021930,GO:0051131,GO:0060090,GO:0070628,GO:0080129,GO:0101031" protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|Golgi apparatus|cytosol|cerebellar granule cell precursor proliferation|chaperone-mediated protein complex assembly|molecular adaptor activity|proteasome binding|proteasome core complex assembly|chaperone complex PSMG2 1000.794582 859.6677052 1141.921459 1.328328902 0.40961241 0.245161184 1 39.36630791 54.54390618 56984 proteasome assembly chaperone 2 "GO:0005515,GO:0005634,GO:0005829,GO:0007094,GO:0043066,GO:0043248,GO:0051131,GO:0060090,GO:0101031" protein binding|nucleus|cytosol|mitotic spindle assembly checkpoint|negative regulation of apoptotic process|proteasome assembly|chaperone-mediated protein complex assembly|molecular adaptor activity|chaperone complex PSMG3 583.5568744 591.7193296 575.3944193 0.972411058 -0.040361796 0.922719453 1 20.739444 21.03598865 84262 proteasome assembly chaperone 3 "GO:0005515,GO:0032991,GO:0044877,GO:0051131,GO:0060090" protein binding|protein-containing complex|protein-containing complex binding|chaperone-mediated protein complex assembly|molecular adaptor activity PSMG4 143.686539 157.3181751 130.054903 0.826699794 -0.274564567 0.653862776 1 1.105231042 0.953052519 389362 proteasome assembly chaperone 4 "GO:0032991,GO:0043248,GO:0044877" protein-containing complex|proteasome assembly|protein-containing complex binding PSORS1C1 29.04773291 32.47859099 25.61687483 0.788731101 -0.342394563 0.755629422 1 1.751784937 1.441204746 170679 psoriasis susceptibility 1 candidate 1 PSPC1 852.5283708 1029.165352 675.8913898 0.656737412 -0.606611452 0.094906501 1 6.579600404 4.507203901 55269 paraspeckle component 1 "GO:0000398,GO:0000976,GO:0001650,GO:0002218,GO:0003676,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0016363,GO:0016607,GO:0042752,GO:0045087,GO:0045892,GO:0048511" "mRNA splicing, via spliceosome|transcription regulatory region sequence-specific DNA binding|fibrillar center|activation of innate immune response|nucleic acid binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|nuclear matrix|nuclear speck|regulation of circadian rhythm|innate immune response|negative regulation of transcription, DNA-templated|rhythmic process" PSPH 588.4765155 490.2237327 686.7292983 1.40084874 0.486301186 0.215842191 1 7.899491778 11.54267121 5723 phosphoserine phosphatase "GO:0000287,GO:0001701,GO:0004647,GO:0005509,GO:0005737,GO:0005829,GO:0006563,GO:0006564,GO:0009612,GO:0016311,GO:0031667,GO:0033574,GO:0042802,GO:0042803,GO:0043005" magnesium ion binding|in utero embryonic development|phosphoserine phosphatase activity|calcium ion binding|cytoplasm|cytosol|L-serine metabolic process|L-serine biosynthetic process|response to mechanical stimulus|dephosphorylation|response to nutrient levels|response to testosterone|identical protein binding|protein homodimerization activity|neuron projection hsa00260 "Glycine, serine and threonine metabolism" PSPN 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.29331777 0.222751771 5623 persephin "GO:0000165,GO:0005102,GO:0005576,GO:0005615,GO:0007399,GO:0007411,GO:0007417,GO:0008083,GO:0030116,GO:0030971" MAPK cascade|signaling receptor binding|extracellular region|extracellular space|nervous system development|axon guidance|central nervous system development|growth factor activity|glial cell-derived neurotrophic factor receptor binding|receptor tyrosine kinase binding PSRC1 801.4284792 667.8410272 935.0159313 1.400057638 0.485486222 0.186377702 1 19.02350508 27.78128845 84722 proline and serine rich coiled-coil 1 "GO:0000922,GO:0001578,GO:0005515,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0005876,GO:0007080,GO:0008017,GO:0015630,GO:0030308,GO:0030496,GO:0031116,GO:0045737,GO:0045893,GO:0051301,GO:0060236" "spindle pole|microtubule bundle formation|protein binding|nucleoplasm|cytoplasm|spindle|cytosol|spindle microtubule|mitotic metaphase plate congression|microtubule binding|microtubule cytoskeleton|negative regulation of cell growth|midbody|positive regulation of microtubule polymerization|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription, DNA-templated|cell division|regulation of mitotic spindle organization" PSTK 19.47988009 18.26920743 20.69055275 1.132536966 0.17955814 0.919067072 1 0.688445615 0.813275995 118672 phosphoseryl-tRNA kinase "GO:0000049,GO:0005524,GO:0006412,GO:0016301,GO:0016310,GO:0043915,GO:0097056" tRNA binding|ATP binding|translation|kinase activity|phosphorylation|L-seryl-tRNA(Sec) kinase activity|selenocysteinyl-tRNA(Sec) biosynthetic process "hsa00450,hsa00970" Selenocompound metabolism|Aminoacyl-tRNA biosynthesis PSTPIP2 258.3901715 219.2304892 297.5498538 1.357246681 0.440682956 0.375371418 1 3.574774912 5.060849465 9050 proline-serine-threonine phosphatase interacting protein 2 "GO:0005737,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0016477,GO:0030041,GO:0051015" cytoplasm|cytosol|cytoskeleton|actin filament|plasma membrane|cell migration|actin filament polymerization|actin filament binding PTAR1 1447.05429 1293.053904 1601.054677 1.238196391 0.308240159 0.354879555 1 6.398497177 8.263869421 375743 protein prenyltransferase alpha subunit repeat containing 1 "GO:0005737,GO:0008318,GO:0018215,GO:0018342" cytoplasm|protein prenyltransferase activity|protein phosphopantetheinylation|protein prenylation PTBP1 7722.386974 7300.578281 8144.195667 1.115554872 0.157761478 0.632436284 1 96.61576562 112.4229214 5725 polypyrimidine tract binding protein 1 "GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006397,GO:0006417,GO:0008187,GO:0008380,GO:0008543,GO:0016020,GO:0016070,GO:0033119,GO:0035307,GO:0036002,GO:0043484,GO:0045595,GO:0048025,GO:0051148,GO:0070062,GO:0070886,GO:0075522" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|mRNA processing|regulation of translation|poly-pyrimidine tract binding|RNA splicing|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|negative regulation of RNA splicing|positive regulation of protein dephosphorylation|pre-mRNA binding|regulation of RNA splicing|regulation of cell differentiation|negative regulation of mRNA splicing, via spliceosome|negative regulation of muscle cell differentiation|extracellular exosome|positive regulation of calcineurin-NFAT signaling cascade|IRES-dependent viral translational initiation" PTBP2 349.3771884 411.0571672 287.6972096 0.69989586 -0.51478782 0.254159506 1 6.16847271 4.503259793 58155 polypyrimidine tract binding protein 2 "GO:0003723,GO:0003729,GO:0005634,GO:0005681,GO:0006376,GO:0006417,GO:0021510,GO:0021549,GO:0030426,GO:0033119,GO:0043025,GO:0043484,GO:2000177" RNA binding|mRNA binding|nucleus|spliceosomal complex|mRNA splice site selection|regulation of translation|spinal cord development|cerebellum development|growth cone|negative regulation of RNA splicing|neuronal cell body|regulation of RNA splicing|regulation of neural precursor cell proliferation PTBP3 1769.240706 1966.984667 1571.496744 0.798936957 -0.323846428 0.319967651 1 12.22191563 10.18515687 9991 polypyrimidine tract binding protein 3 "GO:0003723,GO:0003729,GO:0005634,GO:0006397,GO:0006417,GO:0008380,GO:0009653,GO:0033119,GO:0043249,GO:0043484,GO:0045595,GO:0048025" "RNA binding|mRNA binding|nucleus|mRNA processing|regulation of translation|RNA splicing|anatomical structure morphogenesis|negative regulation of RNA splicing|erythrocyte maturation|regulation of RNA splicing|regulation of cell differentiation|negative regulation of mRNA splicing, via spliceosome" PTCD1 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.028223246 0.019051853 26024 pentatricopeptide repeat domain 1 "GO:0000049,GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0042780" tRNA binding|RNA binding|protein binding|mitochondrion|mitochondrial matrix|tRNA 3'-end processing PTCD2 229.0225125 265.9184637 192.1265612 0.722501772 -0.468926969 0.364282217 1 6.788221816 5.115768358 79810 pentatricopeptide repeat domain 2 "GO:0001822,GO:0001889,GO:0003723,GO:0005515,GO:0005739,GO:0006397,GO:0007005,GO:0007275,GO:0010468,GO:0048747,GO:0050684,GO:0055010" kidney development|liver development|RNA binding|protein binding|mitochondrion|mRNA processing|mitochondrion organization|multicellular organism development|regulation of gene expression|muscle fiber development|regulation of mRNA processing|ventricular cardiac muscle tissue morphogenesis PTCD3 1072.257182 1030.180308 1114.334055 1.081688367 0.113284921 0.746735304 1 7.809459413 8.811281193 55037 pentatricopeptide repeat domain 3 "GO:0003723,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0019843,GO:0032543,GO:0043024,GO:0070125,GO:0070126" RNA binding|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|cytosol|ribosome|plasma membrane|regulation of translation|rRNA binding|mitochondrial translation|ribosomal small subunit binding|mitochondrial translational elongation|mitochondrial translational termination PTCH1 606.0789008 649.5718198 562.5859818 0.866087421 -0.207415441 0.596631959 1 3.337918133 3.015458399 5727 patched 1 "GO:0000122,GO:0001658,GO:0001701,GO:0001709,GO:0001843,GO:0003007,GO:0005113,GO:0005119,GO:0005515,GO:0005634,GO:0005794,GO:0005886,GO:0005901,GO:0007224,GO:0007346,GO:0007420,GO:0008158,GO:0008201,GO:0008589,GO:0009612,GO:0009887,GO:0009953,GO:0009957,GO:0010157,GO:0010875,GO:0014069,GO:0015485,GO:0016021,GO:0016485,GO:0021522,GO:0021532,GO:0021997,GO:0030326,GO:0030332,GO:0030496,GO:0030666,GO:0030850,GO:0032355,GO:0032526,GO:0032880,GO:0035108,GO:0035137,GO:0040015,GO:0042493,GO:0042593,GO:0043231,GO:0043433,GO:0043616,GO:0044294,GO:0044295,GO:0044877,GO:0045177,GO:0045606,GO:0045668,GO:0045879,GO:0045893,GO:0048471,GO:0048568,GO:0048745,GO:0050680,GO:0051782,GO:0060037,GO:0060170,GO:0060603,GO:0060644,GO:0060831,GO:0061005,GO:0061053,GO:0071397,GO:0071679,GO:0072203,GO:0072205,GO:0072659,GO:0097108,GO:0097421" "negative regulation of transcription by RNA polymerase II|branching involved in ureteric bud morphogenesis|in utero embryonic development|cell fate determination|neural tube closure|heart morphogenesis|patched binding|smoothened binding|protein binding|nucleus|Golgi apparatus|plasma membrane|caveola|smoothened signaling pathway|regulation of mitotic cell cycle|brain development|hedgehog receptor activity|heparin binding|regulation of smoothened signaling pathway|response to mechanical stimulus|animal organ morphogenesis|dorsal/ventral pattern formation|epidermal cell fate specification|response to chlorate|positive regulation of cholesterol efflux|postsynaptic density|cholesterol binding|integral component of membrane|protein processing|spinal cord motor neuron differentiation|neural tube patterning|neural plate axis specification|embryonic limb morphogenesis|cyclin binding|midbody|endocytic vesicle membrane|prostate gland development|response to estradiol|response to retinoic acid|regulation of protein localization|limb morphogenesis|hindlimb morphogenesis|negative regulation of multicellular organism growth|response to drug|glucose homeostasis|intracellular membrane-bounded organelle|negative regulation of DNA-binding transcription factor activity|keratinocyte proliferation|dendritic growth cone|axonal growth cone|protein-containing complex binding|apical part of cell|positive regulation of epidermal cell differentiation|negative regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm|embryonic organ development|smooth muscle tissue development|negative regulation of epithelial cell proliferation|negative regulation of cell division|pharyngeal system development|ciliary membrane|mammary gland duct morphogenesis|mammary gland epithelial cell differentiation|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|cell differentiation involved in kidney development|somite development|cellular response to cholesterol|commissural neuron axon guidance|cell proliferation involved in metanephros development|metanephric collecting duct development|protein localization to plasma membrane|hedgehog family protein binding|liver regeneration" "hsa04024,hsa04340,hsa04360,hsa05200,hsa05205,hsa05217" cAMP signaling pathway|Hedgehog signaling pathway|Axon guidance|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma PTCH2 13.47921893 12.17947162 14.77896625 1.213432463 0.279093814 0.880229941 1 0.117048818 0.148148948 8643 patched 2 "GO:0001558,GO:0001709,GO:0005119,GO:0005886,GO:0007224,GO:0008158,GO:0009957,GO:0016021,GO:0042633,GO:0043588,GO:0045606,GO:0045879,GO:0097108" regulation of cell growth|cell fate determination|smoothened binding|plasma membrane|smoothened signaling pathway|hedgehog receptor activity|epidermal cell fate specification|integral component of membrane|hair cycle|skin development|positive regulation of epidermal cell differentiation|negative regulation of smoothened signaling pathway|hedgehog family protein binding "hsa04340,hsa05200,hsa05217" Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma PTCHD4 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.007289788 0.00553602 442213 patched domain containing 4 "GO:0003674,GO:0005575,GO:0008150,GO:0016020,GO:0016021" molecular_function|cellular_component|biological_process|membrane|integral component of membrane PTDSS1 3893.165961 3697.484593 4088.847329 1.10584567 0.14515006 0.648935313 1 37.52796607 43.28779647 9791 phosphatidylserine synthase 1 "GO:0005789,GO:0006659,GO:0016020,GO:0016021,GO:0016740,GO:0106245,GO:0106258" endoplasmic reticulum membrane|phosphatidylserine biosynthetic process|membrane|integral component of membrane|transferase activity|L-serine-phosphatidylethanolamine phosphatidyltransferase activity|L-serine-phosphatidylcholine phosphatidyltransferase activity hsa00564 Glycerophospholipid metabolism PTDSS2 1650.239963 1510.254481 1790.225445 1.185379992 0.245349612 0.454574383 1 14.66431396 18.13156422 81490 phosphatidylserine synthase 2 "GO:0003882,GO:0005789,GO:0006659,GO:0016020,GO:0016021,GO:0016740,GO:0106245" CDP-diacylglycerol-serine O-phosphatidyltransferase activity|endoplasmic reticulum membrane|phosphatidylserine biosynthetic process|membrane|integral component of membrane|transferase activity|L-serine-phosphatidylethanolamine phosphatidyltransferase activity hsa00564 Glycerophospholipid metabolism PTEN 2452.124456 2445.028928 2459.219984 1.005804044 0.008349259 0.980551849 1 14.27623814 14.97762977 5728 phosphatase and tensin homolog "GO:0001525,GO:0001933,GO:0002902,GO:0004438,GO:0004721,GO:0004722,GO:0004725,GO:0005161,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006367,GO:0006470,GO:0006661,GO:0006915,GO:0007270,GO:0007416,GO:0007417,GO:0007507,GO:0007568,GO:0007584,GO:0007611,GO:0007613,GO:0007626,GO:0008138,GO:0008284,GO:0008285,GO:0008289,GO:0009749,GO:0009898,GO:0010043,GO:0010628,GO:0010666,GO:0010719,GO:0010975,GO:0010977,GO:0010997,GO:0014065,GO:0014067,GO:0014823,GO:0016311,GO:0016314,GO:0016324,GO:0016477,GO:0016579,GO:0016605,GO:0019899,GO:0021542,GO:0021955,GO:0030165,GO:0030336,GO:0030534,GO:0031642,GO:0031647,GO:0032228,GO:0032286,GO:0032355,GO:0032535,GO:0032869,GO:0033032,GO:0033137,GO:0033198,GO:0033555,GO:0035176,GO:0035255,GO:0035335,GO:0035749,GO:0042493,GO:0042711,GO:0042802,GO:0042995,GO:0043005,GO:0043066,GO:0043197,GO:0043220,GO:0043491,GO:0043542,GO:0043647,GO:0044320,GO:0045211,GO:0045475,GO:0045666,GO:0045736,GO:0045792,GO:0046621,GO:0046685,GO:0046855,GO:0046856,GO:0048008,GO:0048681,GO:0048738,GO:0048853,GO:0048854,GO:0048870,GO:0050680,GO:0050765,GO:0050771,GO:0050821,GO:0051091,GO:0051548,GO:0051717,GO:0051800,GO:0051895,GO:0051896,GO:0051898,GO:0060024,GO:0060044,GO:0060070,GO:0060074,GO:0060134,GO:0060179,GO:0060291,GO:0060292,GO:0060736,GO:0060997,GO:0061002,GO:0070373,GO:0070374,GO:0071257,GO:0071361,GO:0071456,GO:0090071,GO:0090344,GO:0090394,GO:0097105,GO:0097107,GO:0099524,GO:0106306,GO:0106307,GO:1901017,GO:1902807,GO:1903690,GO:1903984,GO:1904668,GO:1904706,GO:1990090,GO:1990314,GO:1990381,GO:1990782,GO:2000060,GO:2000134,GO:2000272,GO:2000463,GO:2000808" "angiogenesis|negative regulation of protein phosphorylation|regulation of B cell apoptotic process|phosphatidylinositol-3-phosphatase activity|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|platelet-derived growth factor receptor binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|transcription initiation from RNA polymerase II promoter|protein dephosphorylation|phosphatidylinositol biosynthetic process|apoptotic process|neuron-neuron synaptic transmission|synapse assembly|central nervous system development|heart development|aging|response to nutrient|learning or memory|memory|locomotory behavior|protein tyrosine/serine/threonine phosphatase activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|lipid binding|response to glucose|cytoplasmic side of plasma membrane|response to zinc ion|positive regulation of gene expression|positive regulation of cardiac muscle cell apoptotic process|negative regulation of epithelial to mesenchymal transition|regulation of neuron projection development|negative regulation of neuron projection development|anaphase-promoting complex binding|phosphatidylinositol 3-kinase signaling|negative regulation of phosphatidylinositol 3-kinase signaling|response to activity|dephosphorylation|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|apical plasma membrane|cell migration|protein deubiquitination|PML body|enzyme binding|dentate gyrus development|central nervous system neuron axonogenesis|PDZ domain binding|negative regulation of cell migration|adult behavior|negative regulation of myelination|regulation of protein stability|regulation of synaptic transmission, GABAergic|central nervous system myelin maintenance|response to estradiol|regulation of cellular component size|cellular response to insulin stimulus|regulation of myeloid cell apoptotic process|negative regulation of peptidyl-serine phosphorylation|response to ATP|multicellular organismal response to stress|social behavior|ionotropic glutamate receptor binding|peptidyl-tyrosine dephosphorylation|myelin sheath adaxonal region|response to drug|maternal behavior|identical protein binding|cell projection|neuron projection|negative regulation of apoptotic process|dendritic spine|Schmidt-Lanterman incisure|protein kinase B signaling|endothelial cell migration|inositol phosphate metabolic process|cellular response to leptin stimulus|postsynaptic membrane|locomotor rhythm|positive regulation of neuron differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of cell size|negative regulation of organ growth|response to arsenic-containing substance|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|platelet-derived growth factor receptor signaling pathway|negative regulation of axon regeneration|cardiac muscle tissue development|forebrain morphogenesis|brain morphogenesis|cell motility|negative regulation of epithelial cell proliferation|negative regulation of phagocytosis|negative regulation of axonogenesis|protein stabilization|positive regulation of DNA-binding transcription factor activity|negative regulation of keratinocyte migration|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|negative regulation of focal adhesion assembly|regulation of protein kinase B signaling|negative regulation of protein kinase B signaling|rhythmic synaptic transmission|negative regulation of cardiac muscle cell proliferation|canonical Wnt signaling pathway|synapse maturation|prepulse inhibition|male mating behavior|long-term synaptic potentiation|long-term synaptic depression|prostate gland growth|dendritic spine morphogenesis|negative regulation of dendritic spine morphogenesis|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to electrical stimulus|cellular response to ethanol|cellular response to hypoxia|negative regulation of ribosome biogenesis|negative regulation of cell aging|negative regulation of excitatory postsynaptic potential|presynaptic membrane assembly|postsynaptic density assembly|postsynaptic cytosol|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of potassium ion transmembrane transporter activity|negative regulation of cell cycle G1/S phase transition|negative regulation of wound healing, spreading of epidermal cells|positive regulation of TRAIL-activated apoptotic signaling pathway|positive regulation of ubiquitin protein ligase activity|negative regulation of vascular associated smooth muscle cell proliferation|cellular response to nerve growth factor stimulus|cellular response to insulin-like growth factor stimulus|ubiquitin-specific protease binding|protein tyrosine kinase binding|positive regulation of ubiquitin-dependent protein catabolic process|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of signaling receptor activity|positive regulation of excitatory postsynaptic potential|negative regulation of synaptic vesicle clustering" "hsa00562,hsa01521,hsa04068,hsa04070,hsa04071,hsa04115,hsa04140,hsa04150,hsa04151,hsa04218,hsa04510,hsa04931,hsa05165,hsa05166,hsa05200,hsa05206,hsa05213,hsa05214,hsa05215,hsa05218,hsa05222,hsa05224,hsa05225,hsa05230,hsa05235" Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|p53 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Focal adhesion|Insulin resistance|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Central carbon metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer PTER 245.2969427 233.4398727 257.1540127 1.101585645 0.139581664 0.788251288 1 3.086920634 3.546987527 9317 phosphotriesterase related "GO:0003674,GO:0005515,GO:0008270,GO:0009056,GO:0016788,GO:0030855,GO:0070062" "molecular_function|protein binding|zinc ion binding|catabolic process|hydrolase activity, acting on ester bonds|epithelial cell differentiation|extracellular exosome" PTGER2 37.25645531 54.80762229 19.70528833 0.359535545 -1.475793689 0.115081907 1 1.129297282 0.423512317 5732 prostaglandin E receptor 2 "GO:0004957,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007189,GO:0007204,GO:0071380,GO:1904346" prostaglandin E receptor activity|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cellular response to prostaglandin E stimulus|positive regulation of gastric mucosal blood circulation "hsa04024,hsa04080,hsa04750,hsa04924,hsa05163,hsa05200" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels|Renin secretion|Human cytomegalovirus infection|Pathways in cancer PTGER4 19.98735807 19.2841634 20.69055275 1.072929757 0.101555628 0.977329228 1 0.428930543 0.480036424 5734 prostaglandin E receptor 4 "GO:0001818,GO:0001819,GO:0004957,GO:0005515,GO:0005886,GO:0006954,GO:0006955,GO:0007186,GO:0007188,GO:0007189,GO:0007204,GO:0007254,GO:0009612,GO:0016021,GO:0030278,GO:0032496,GO:0033624,GO:0042093,GO:0050728,GO:0050729,GO:0051492,GO:0060348,GO:0070371,GO:0071260,GO:0071380,GO:2000420" negative regulation of cytokine production|positive regulation of cytokine production|prostaglandin E receptor activity|protein binding|plasma membrane|inflammatory response|immune response|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|JNK cascade|response to mechanical stimulus|integral component of membrane|regulation of ossification|response to lipopolysaccharide|negative regulation of integrin activation|T-helper cell differentiation|negative regulation of inflammatory response|positive regulation of inflammatory response|regulation of stress fiber assembly|bone development|ERK1 and ERK2 cascade|cellular response to mechanical stimulus|cellular response to prostaglandin E stimulus|negative regulation of eosinophil extravasation "hsa04080,hsa04750,hsa04924,hsa05163,hsa05165,hsa05200" Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels|Renin secretion|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer PTGES 575.468156 745.9926368 404.9436752 0.542825298 -0.881440137 0.026187049 0.720197064 21.57732458 12.21725402 9536 prostaglandin E synthase "GO:0001516,GO:0002526,GO:0002544,GO:0004364,GO:0004602,GO:0004667,GO:0005515,GO:0005641,GO:0005789,GO:0006693,GO:0007165,GO:0008285,GO:0014070,GO:0016020,GO:0016021,GO:0019233,GO:0019371,GO:0031620,GO:0032308,GO:0032496,GO:0032526,GO:0034097,GO:0043295,GO:0048471,GO:0050220,GO:0050727,GO:0051592,GO:0055114,GO:0098869" prostaglandin biosynthetic process|acute inflammatory response|chronic inflammatory response|glutathione transferase activity|glutathione peroxidase activity|prostaglandin-D synthase activity|protein binding|nuclear envelope lumen|endoplasmic reticulum membrane|prostaglandin metabolic process|signal transduction|negative regulation of cell population proliferation|response to organic cyclic compound|membrane|integral component of membrane|sensory perception of pain|cyclooxygenase pathway|regulation of fever generation|positive regulation of prostaglandin secretion|response to lipopolysaccharide|response to retinoic acid|response to cytokine|glutathione binding|perinuclear region of cytoplasm|prostaglandin-E synthase activity|regulation of inflammatory response|response to calcium ion|oxidation-reduction process|cellular oxidant detoxification hsa00590 Arachidonic acid metabolism PTGES2 1356.867215 1728.470014 985.2644165 0.570021122 -0.810912716 0.016229785 0.562985307 45.17074744 26.85741161 80142 prostaglandin E synthase 2 "GO:0000139,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005739,GO:0005829,GO:0006629,GO:0006749,GO:0015035,GO:0016021,GO:0016829,GO:0019371,GO:0020037,GO:0035578,GO:0043295,GO:0043312,GO:0045893,GO:0048471,GO:0050220,GO:0055114" "Golgi membrane|DNA binding|protein binding|extracellular region|nucleus|mitochondrion|cytosol|lipid metabolic process|glutathione metabolic process|protein disulfide oxidoreductase activity|integral component of membrane|lyase activity|cyclooxygenase pathway|heme binding|azurophil granule lumen|glutathione binding|neutrophil degranulation|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm|prostaglandin-E synthase activity|oxidation-reduction process" hsa00590 Arachidonic acid metabolism PTGES3 6247.295701 6212.545482 6282.04592 1.011187111 0.01604998 0.961145886 1 90.70150249 95.6669518 10728 prostaglandin E synthase 3 "GO:0000723,GO:0000781,GO:0001516,GO:0003720,GO:0005515,GO:0005634,GO:0005654,GO:0005697,GO:0005829,GO:0006457,GO:0006805,GO:0007004,GO:0007165,GO:0019371,GO:0032991,GO:0042327,GO:0050220,GO:0050821,GO:0051082,GO:0051085,GO:0051087,GO:0051131,GO:0051879,GO:0051973,GO:0070182,GO:0101031,GO:1900034,GO:1905323" "telomere maintenance|chromosome, telomeric region|prostaglandin biosynthetic process|telomerase activity|protein binding|nucleus|nucleoplasm|telomerase holoenzyme complex|cytosol|protein folding|xenobiotic metabolic process|telomere maintenance via telomerase|signal transduction|cyclooxygenase pathway|protein-containing complex|positive regulation of phosphorylation|prostaglandin-E synthase activity|protein stabilization|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|chaperone-mediated protein complex assembly|Hsp90 protein binding|positive regulation of telomerase activity|DNA polymerase binding|chaperone complex|regulation of cellular response to heat|telomerase holoenzyme complex assembly" hsa00590 Arachidonic acid metabolism PTGES3L 29.48098201 28.41876711 30.54319691 1.074754467 0.104007107 0.953101443 1 0.932799935 1.045715862 100885848 prostaglandin E synthase 3 like "GO:0005634,GO:0005829,GO:0006457,GO:0051087,GO:0051131,GO:0051879" nucleus|cytosol|protein folding|chaperone binding|chaperone-mediated protein complex assembly|Hsp90 protein binding PTGES3L-AARSD1 5.508028946 6.08973581 4.926322083 0.808954975 -0.305868687 0.976518791 1 0.135154967 0.114043961 100885850 PTGES3L-AARSD1 readthrough PTGFRN 1716.735908 1442.252431 1991.219386 1.380631672 0.465328486 0.15440826 1 11.37772549 16.38510442 5738 prostaglandin F2 receptor inhibitor "GO:0005515,GO:0005789,GO:0005794,GO:0009986,GO:0014905,GO:0016021,GO:0034389" protein binding|endoplasmic reticulum membrane|Golgi apparatus|cell surface|myoblast fusion involved in skeletal muscle regeneration|integral component of membrane|lipid droplet organization PTGIR 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.074211654 0.025047961 5739 prostaglandin I2 receptor "GO:0005085,GO:0005829,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007187,GO:0007189,GO:0007204,GO:0007267,GO:0010642,GO:0016501,GO:0032496,GO:0048662,GO:0050790" "guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|negative regulation of platelet-derived growth factor receptor signaling pathway|prostacyclin receptor activity|response to lipopolysaccharide|negative regulation of smooth muscle cell proliferation|regulation of catalytic activity" "hsa04080,hsa04270,hsa04611" Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Platelet activation PTGR1 1228.808819 1225.051854 1232.565785 1.006133562 0.008821832 0.982019391 1 29.19743749 30.6419432 22949 prostaglandin reductase 1 "GO:0005515,GO:0005737,GO:0006691,GO:0006693,GO:0035798,GO:0036102,GO:0036132,GO:0036185,GO:0047522,GO:0055114,GO:0070062,GO:0097257,GO:0097327,GO:2001302" protein binding|cytoplasm|leukotriene metabolic process|prostaglandin metabolic process|2-alkenal reductase (NADP+) activity|leukotriene B4 metabolic process|13-prostaglandin reductase activity|13-lipoxin reductase activity|15-oxoprostaglandin 13-oxidase activity|oxidation-reduction process|extracellular exosome|leukotriene B4 12-hydroxy dehydrogenase activity|response to antineoplastic agent|lipoxin A4 metabolic process PTGR2 145.5234559 148.1835714 142.8633404 0.964097026 -0.05274975 0.941816875 1 1.963111465 1.974156745 145482 prostaglandin reductase 2 "GO:0005515,GO:0005737,GO:0006693,GO:0008270,GO:0036132,GO:0047522,GO:0055114" protein binding|cytoplasm|prostaglandin metabolic process|zinc ion binding|13-prostaglandin reductase activity|15-oxoprostaglandin 13-oxidase activity|oxidation-reduction process PTGS1 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.024741187 0.00835066 5742 prostaglandin-endoperoxide synthase 1 "GO:0001516,GO:0001750,GO:0004601,GO:0004666,GO:0005515,GO:0005737,GO:0005789,GO:0005794,GO:0006805,GO:0006954,GO:0006979,GO:0008217,GO:0019371,GO:0020037,GO:0042127,GO:0043231,GO:0046872,GO:0051213,GO:0055114,GO:0070062,GO:0098869" prostaglandin biosynthetic process|photoreceptor outer segment|peroxidase activity|prostaglandin-endoperoxide synthase activity|protein binding|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|xenobiotic metabolic process|inflammatory response|response to oxidative stress|regulation of blood pressure|cyclooxygenase pathway|heme binding|regulation of cell population proliferation|intracellular membrane-bounded organelle|metal ion binding|dioxygenase activity|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification "hsa00590,hsa04611,hsa04726,hsa04923" Arachidonic acid metabolism|Platelet activation|Serotonergic synapse|Regulation of lipolysis in adipocytes PTGS2 809.5275919 1120.511389 498.5437948 0.444925236 -1.168365163 0.001607032 0.125182231 12.58313724 5.839718367 5743 prostaglandin-endoperoxide synthase 2 "GO:0001516,GO:0004601,GO:0004666,GO:0005515,GO:0005637,GO:0005640,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0006954,GO:0006979,GO:0008217,GO:0010575,GO:0019221,GO:0019371,GO:0019372,GO:0019899,GO:0020037,GO:0031394,GO:0031622,GO:0034356,GO:0042759,GO:0043005,GO:0045429,GO:0046872,GO:0050727,GO:0051213,GO:0055114,GO:0071456,GO:0071636,GO:0090050,GO:0090271,GO:0090336,GO:0090362,GO:0098869,GO:0150077" prostaglandin biosynthetic process|peroxidase activity|prostaglandin-endoperoxide synthase activity|protein binding|nuclear inner membrane|nuclear outer membrane|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|inflammatory response|response to oxidative stress|regulation of blood pressure|positive regulation of vascular endothelial growth factor production|cytokine-mediated signaling pathway|cyclooxygenase pathway|lipoxygenase pathway|enzyme binding|heme binding|positive regulation of prostaglandin biosynthetic process|positive regulation of fever generation|NAD biosynthesis via nicotinamide riboside salvage pathway|long-chain fatty acid biosynthetic process|neuron projection|positive regulation of nitric oxide biosynthetic process|metal ion binding|regulation of inflammatory response|dioxygenase activity|oxidation-reduction process|cellular response to hypoxia|positive regulation of transforming growth factor beta production|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fibroblast growth factor production|positive regulation of brown fat cell differentiation|positive regulation of platelet-derived growth factor production|cellular oxidant detoxification|regulation of neuroinflammatory response "hsa00590,hsa04064,hsa04370,hsa04625,hsa04657,hsa04668,hsa04723,hsa04726,hsa04913,hsa04921,hsa04923,hsa05010,hsa05022,hsa05140,hsa05163,hsa05165,hsa05167,hsa05200,hsa05204,hsa05206,hsa05222" Arachidonic acid metabolism|NF-kappa B signaling pathway|VEGF signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Retrograde endocannabinoid signaling|Serotonergic synapse|Ovarian steroidogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Leishmaniasis|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Chemical carcinogenesis|MicroRNAs in cancer|Small cell lung cancer PTH1R 28.34725984 18.26920743 38.42531225 2.103282936 1.072642936 0.289726151 1 0.19336905 0.424229234 5745 parathyroid hormone 1 receptor "GO:0001501,GO:0001701,GO:0002062,GO:0002076,GO:0004991,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0006874,GO:0007166,GO:0007186,GO:0007187,GO:0007188,GO:0007189,GO:0007200,GO:0007204,GO:0007568,GO:0008284,GO:0008285,GO:0008528,GO:0016323,GO:0016324,GO:0017046,GO:0030282,GO:0031526,GO:0042803,GO:0043235,GO:0043621,GO:0045453,GO:0048469,GO:0060732" "skeletal system development|in utero embryonic development|chondrocyte differentiation|osteoblast development|parathyroid hormone receptor activity|protein binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|aging|positive regulation of cell population proliferation|negative regulation of cell population proliferation|G protein-coupled peptide receptor activity|basolateral plasma membrane|apical plasma membrane|peptide hormone binding|bone mineralization|brush border membrane|protein homodimerization activity|receptor complex|protein self-association|bone resorption|cell maturation|positive regulation of inositol phosphate biosynthetic process" "hsa04080,hsa04928,hsa04961" "Neuroactive ligand-receptor interaction|Parathyroid hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption" PTHLH 108.1158212 116.7199364 99.51170607 0.8525682 -0.230112849 0.737011218 1 1.851378958 1.646419052 5744 parathyroid hormone like hormone "GO:0001501,GO:0002076,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0007186,GO:0007189,GO:0007267,GO:0007565,GO:0008284,GO:0008285,GO:0008544,GO:0010468,GO:0030282,GO:0032330,GO:0032331,GO:0046058,GO:0051428,GO:0061182" skeletal system development|osteoblast development|hormone activity|protein binding|extracellular region|extracellular space|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|cell-cell signaling|female pregnancy|positive regulation of cell population proliferation|negative regulation of cell population proliferation|epidermis development|regulation of gene expression|bone mineralization|regulation of chondrocyte differentiation|negative regulation of chondrocyte differentiation|cAMP metabolic process|peptide hormone receptor binding|negative regulation of chondrocyte development hsa04928 "Parathyroid hormone synthesis, secretion and action" PTK2 4288.593993 4326.757293 4250.430693 0.982359399 -0.02567716 0.936626878 1 24.81991086 25.43235352 5747 protein tyrosine kinase 2 "GO:0000165,GO:0001525,GO:0001725,GO:0001890,GO:0001932,GO:0001934,GO:0003007,GO:0003779,GO:0004672,GO:0004713,GO:0004715,GO:0005102,GO:0005178,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007169,GO:0007172,GO:0007173,GO:0007179,GO:0007229,GO:0007411,GO:0008284,GO:0008360,GO:0008432,GO:0010594,GO:0010632,GO:0010759,GO:0010763,GO:0014068,GO:0018108,GO:0019901,GO:0019903,GO:0022408,GO:0030010,GO:0030154,GO:0030155,GO:0030335,GO:0031234,GO:0033628,GO:0035995,GO:0036064,GO:0038007,GO:0038083,GO:0038096,GO:0042127,GO:0042169,GO:0043066,GO:0043087,GO:0043197,GO:0043231,GO:0043552,GO:0045087,GO:0045667,GO:0045860,GO:0046777,GO:0048010,GO:0048013,GO:0048870,GO:0051493,GO:0051893,GO:0051897,GO:0060396,GO:0090303,GO:0120041,GO:1900024,GO:2000060,GO:2000811" MAPK cascade|angiogenesis|stress fiber|placenta development|regulation of protein phosphorylation|positive regulation of protein phosphorylation|heart morphogenesis|actin binding|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|integrin binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|transmembrane receptor protein tyrosine kinase signaling pathway|signal complex assembly|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|axon guidance|positive regulation of cell population proliferation|regulation of cell shape|JUN kinase binding|regulation of endothelial cell migration|regulation of epithelial cell migration|positive regulation of macrophage chemotaxis|positive regulation of fibroblast migration|positive regulation of phosphatidylinositol 3-kinase signaling|peptidyl-tyrosine phosphorylation|protein kinase binding|protein phosphatase binding|negative regulation of cell-cell adhesion|establishment of cell polarity|cell differentiation|regulation of cell adhesion|positive regulation of cell migration|extrinsic component of cytoplasmic side of plasma membrane|regulation of cell adhesion mediated by integrin|detection of muscle stretch|ciliary basal body|netrin-activated signaling pathway|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell population proliferation|SH2 domain binding|negative regulation of apoptotic process|regulation of GTPase activity|dendritic spine|intracellular membrane-bounded organelle|positive regulation of phosphatidylinositol 3-kinase activity|innate immune response|regulation of osteoblast differentiation|positive regulation of protein kinase activity|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|cell motility|regulation of cytoskeleton organization|regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|growth hormone receptor signaling pathway|positive regulation of wound healing|positive regulation of macrophage proliferation|regulation of substrate adhesion-dependent cell spreading|positive regulation of ubiquitin-dependent protein catabolic process|negative regulation of anoikis "hsa01522,hsa04012,hsa04062,hsa04151,hsa04360,hsa04370,hsa04510,hsa04670,hsa04810,hsa04935,hsa05100,hsa05131,hsa05135,hsa05146,hsa05163,hsa05165,hsa05170,hsa05200,hsa05202,hsa05205,hsa05222,hsa05418" "Endocrine resistance|ErbB signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Growth hormone synthesis, secretion and action|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|Small cell lung cancer|Fluid shear stress and atherosclerosis" PTK2B 632.9388614 599.8389773 666.0387456 1.110362565 0.151030835 0.698178917 1 5.941664012 6.881590586 2185 protein tyrosine kinase 2 beta "GO:0000165,GO:0001525,GO:0001556,GO:0001666,GO:0001954,GO:0002040,GO:0002250,GO:0002315,GO:0004683,GO:0004713,GO:0004715,GO:0004972,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0005938,GO:0006468,GO:0006915,GO:0006968,GO:0006970,GO:0007165,GO:0007166,GO:0007169,GO:0007172,GO:0007173,GO:0007204,GO:0007229,GO:0008022,GO:0008284,GO:0008285,GO:0008360,GO:0009612,GO:0009725,GO:0009749,GO:0010226,GO:0010595,GO:0010656,GO:0010752,GO:0010758,GO:0010976,GO:0014009,GO:0014069,GO:0017146,GO:0018108,GO:0030027,GO:0030154,GO:0030155,GO:0030307,GO:0030335,GO:0030425,GO:0030426,GO:0030502,GO:0030838,GO:0031175,GO:0031234,GO:0031625,GO:0032960,GO:0033209,GO:0035235,GO:0035902,GO:0038083,GO:0038110,GO:0042127,GO:0042220,GO:0042493,GO:0042542,GO:0042976,GO:0043025,GO:0043066,GO:0043149,GO:0043197,GO:0043267,GO:0043423,GO:0043507,GO:0043524,GO:0043534,GO:0043552,GO:0044297,GO:0044877,GO:0045087,GO:0045121,GO:0045429,GO:0045453,GO:0045471,GO:0045638,GO:0045727,GO:0045766,GO:0045860,GO:0046330,GO:0046777,GO:0048010,GO:0048041,GO:0048167,GO:0048471,GO:0050731,GO:0050848,GO:0051000,GO:0051279,GO:0051591,GO:0051592,GO:0051968,GO:0060291,GO:0060292,GO:0065003,GO:0070098,GO:0070374,GO:0071300,GO:0071498,GO:0086100,GO:0090630,GO:0097440,GO:0098978,GO:2000058,GO:2000060,GO:2000114,GO:2000249,GO:2000310,GO:2000463,GO:2000538,GO:2000573" "MAPK cascade|angiogenesis|oocyte maturation|response to hypoxia|positive regulation of cell-matrix adhesion|sprouting angiogenesis|adaptive immune response|marginal zone B cell differentiation|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|NMDA glutamate receptor activity|signaling receptor binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cytoskeleton|focal adhesion|cell cortex|protein phosphorylation|apoptotic process|cellular defense response|response to osmotic stress|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|signal complex assembly|epidermal growth factor receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|integrin-mediated signaling pathway|protein C-terminus binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of cell shape|response to mechanical stimulus|response to hormone|response to glucose|response to lithium ion|positive regulation of endothelial cell migration|negative regulation of muscle cell apoptotic process|regulation of cGMP-mediated signaling|regulation of macrophage chemotaxis|positive regulation of neuron projection development|glial cell proliferation|postsynaptic density|NMDA selective glutamate receptor complex|peptidyl-tyrosine phosphorylation|lamellipodium|cell differentiation|regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell migration|dendrite|growth cone|negative regulation of bone mineralization|positive regulation of actin filament polymerization|neuron projection development|extrinsic component of cytoplasmic side of plasma membrane|ubiquitin protein ligase binding|regulation of inositol trisphosphate biosynthetic process|tumor necrosis factor-mediated signaling pathway|ionotropic glutamate receptor signaling pathway|response to immobilization stress|peptidyl-tyrosine autophosphorylation|interleukin-2-mediated signaling pathway|regulation of cell population proliferation|response to cocaine|response to drug|response to hydrogen peroxide|activation of Janus kinase activity|neuronal cell body|negative regulation of apoptotic process|stress fiber assembly|dendritic spine|negative regulation of potassium ion transport|3-phosphoinositide-dependent protein kinase binding|positive regulation of JUN kinase activity|negative regulation of neuron apoptotic process|blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|cell body|protein-containing complex binding|innate immune response|membrane raft|positive regulation of nitric oxide biosynthetic process|bone resorption|response to ethanol|negative regulation of myeloid cell differentiation|positive regulation of translation|positive regulation of angiogenesis|positive regulation of protein kinase activity|positive regulation of JNK cascade|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|focal adhesion assembly|regulation of synaptic plasticity|perinuclear region of cytoplasm|positive regulation of peptidyl-tyrosine phosphorylation|regulation of calcium-mediated signaling|positive regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol|response to cAMP|response to calcium ion|positive regulation of synaptic transmission, glutamatergic|long-term synaptic potentiation|long-term synaptic depression|protein-containing complex assembly|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to retinoic acid|cellular response to fluid shear stress|endothelin receptor signaling pathway|activation of GTPase activity|apical dendrite|glutamatergic synapse|regulation of ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-dependent protein catabolic process|regulation of establishment of cell polarity|regulation of actin cytoskeleton reorganization|regulation of NMDA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of B cell chemotaxis|positive regulation of DNA biosynthetic process" "hsa04020,hsa04062,hsa04072,hsa04650,hsa04670,hsa04912,hsa05135,hsa05161,hsa05163,hsa05170" Calcium signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|GnRH signaling pathway|Yersinia infection|Hepatitis B|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection PTK6 162.4511003 160.363043 164.5391576 1.026041627 0.037089263 0.960316102 1 2.774794124 2.96969383 5753 protein tyrosine kinase 6 "GO:0001726,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007169,GO:0007260,GO:0009968,GO:0010976,GO:0016477,GO:0016604,GO:0030154,GO:0031234,GO:0038083,GO:0038128,GO:0042127,GO:0042531,GO:0042802,GO:0045087,GO:0045742,GO:0045787,GO:0045926,GO:0046777,GO:0060575,GO:0061099,GO:0071300" ruffle|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|tyrosine phosphorylation of STAT protein|negative regulation of signal transduction|positive regulation of neuron projection development|cell migration|nuclear body|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|ERBB2 signaling pathway|regulation of cell population proliferation|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|innate immune response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of cell cycle|negative regulation of growth|protein autophosphorylation|intestinal epithelial cell differentiation|negative regulation of protein tyrosine kinase activity|cellular response to retinoic acid PTK7 3431.569828 3327.025664 3536.113991 1.06284542 0.087931787 0.782811342 1 38.32206342 42.48493133 5754 protein tyrosine kinase 7 (inactive) "GO:0001736,GO:0001822,GO:0003281,GO:0003401,GO:0004672,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0006468,GO:0007155,GO:0007165,GO:0010976,GO:0016477,GO:0031532,GO:0042060,GO:0045198,GO:0050839,GO:0060026,GO:0060484,GO:0060828,GO:0060976,GO:0071300,GO:0090103,GO:0090179,GO:0090263,GO:1904929" "establishment of planar polarity|kidney development|ventricular septum development|axis elongation|protein kinase activity|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|protein phosphorylation|cell adhesion|signal transduction|positive regulation of neuron projection development|cell migration|actin cytoskeleton reorganization|wound healing|establishment of epithelial cell apical/basal polarity|cell adhesion molecule binding|convergent extension|lung-associated mesenchyme development|regulation of canonical Wnt signaling pathway|coronary vasculature development|cellular response to retinoic acid|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|positive regulation of canonical Wnt signaling pathway|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway" PTMA 12558.24266 13745.54868 11370.93663 0.827245016 -0.273613401 0.426126843 1 571.5628483 493.1897938 5757 prothymosin alpha "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0033613,GO:0043066" "protein binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|activating transcription factor binding|negative regulation of apoptotic process" PTMS 3355.668341 2853.041227 3858.295455 1.352344796 0.43546303 0.171340262 1 116.6234651 164.5088645 5763 parathymosin "GO:0002376,GO:0005634,GO:0006260" immune system process|nucleus|DNA replication PTN 190.519012 125.8545401 255.1834839 2.027606503 1.019777696 0.063831569 1 3.164890003 6.693576415 5764 pleiotrophin "GO:0001889,GO:0002232,GO:0002690,GO:0004864,GO:0005178,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005783,GO:0005886,GO:0007185,GO:0007229,GO:0007399,GO:0007406,GO:0007507,GO:0007612,GO:0007613,GO:0008083,GO:0008201,GO:0008284,GO:0008360,GO:0009986,GO:0010594,GO:0010811,GO:0010976,GO:0010996,GO:0014823,GO:0016525,GO:0019901,GO:0021510,GO:0021549,GO:0021794,GO:0030282,GO:0030324,GO:0030336,GO:0030501,GO:0031104,GO:0031594,GO:0031641,GO:0032355,GO:0032515,GO:0032570,GO:0032991,GO:0034644,GO:0035373,GO:0035374,GO:0036120,GO:0038085,GO:0042246,GO:0042493,GO:0043065,GO:0043113,GO:0043932,GO:0044849,GO:0045446,GO:0045545,GO:0045778,GO:0045837,GO:0046697,GO:0048167,GO:0048471,GO:0048477,GO:0048680,GO:0048714,GO:0050680,GO:0051781,GO:0060221,GO:0060253,GO:0060291,GO:0071305,GO:0071456,GO:0072201,GO:0098793,GO:0098794,GO:0140059,GO:1900006,GO:1900272,GO:1903706,GO:1904373,GO:1904389,GO:1904391,GO:1904395,GO:1904397,GO:1904399,GO:1990089,GO:2000036,GO:2000347,GO:2000738" liver development|leukocyte chemotaxis involved in inflammatory response|positive regulation of leukocyte chemotaxis|protein phosphatase inhibitor activity|integrin binding|protein binding|extracellular region|basement membrane|extracellular space|endoplasmic reticulum|plasma membrane|transmembrane receptor protein tyrosine phosphatase signaling pathway|integrin-mediated signaling pathway|nervous system development|negative regulation of neuroblast proliferation|heart development|learning|memory|growth factor activity|heparin binding|positive regulation of cell population proliferation|regulation of cell shape|cell surface|regulation of endothelial cell migration|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|response to auditory stimulus|response to activity|negative regulation of angiogenesis|protein kinase binding|spinal cord development|cerebellum development|thalamus development|bone mineralization|lung development|negative regulation of cell migration|positive regulation of bone mineralization|dendrite regeneration|neuromuscular junction|regulation of myelination|response to estradiol|negative regulation of phosphoprotein phosphatase activity|response to progesterone|protein-containing complex|cellular response to UV|chondroitin sulfate proteoglycan binding|chondroitin sulfate binding|cellular response to platelet-derived growth factor stimulus|vascular endothelial growth factor binding|tissue regeneration|response to drug|positive regulation of apoptotic process|receptor clustering|ossification involved in bone remodeling|estrous cycle|endothelial cell differentiation|syndecan binding|positive regulation of ossification|negative regulation of membrane potential|decidualization|regulation of synaptic plasticity|perinuclear region of cytoplasm|oogenesis|positive regulation of axon regeneration|positive regulation of oligodendrocyte differentiation|negative regulation of epithelial cell proliferation|positive regulation of cell division|retinal rod cell differentiation|negative regulation of glial cell proliferation|long-term synaptic potentiation|cellular response to vitamin D|cellular response to hypoxia|negative regulation of mesenchymal cell proliferation|presynapse|postsynapse|dendrite arborization|positive regulation of dendrite development|negative regulation of long-term synaptic potentiation|regulation of hemopoiesis|response to kainic acid|rod bipolar cell differentiation|response to ciliary neurotrophic factor|positive regulation of skeletal muscle acetylcholine-gated channel clustering|negative regulation of neuromuscular junction development|heparan sulfate binding|response to nerve growth factor|regulation of stem cell population maintenance|positive regulation of hepatocyte proliferation|positive regulation of stem cell differentiation PTOV1 1670.383697 1809.666492 1531.100903 0.846067997 -0.24115448 0.46173719 1 19.24679204 16.98554754 53635 PTOV1 extended AT-hook containing adaptor protein "GO:0005654,GO:0005667,GO:0005886,GO:0045944,GO:0048471" nucleoplasm|transcription regulator complex|plasma membrane|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm PTP4A1 1548.635994 1906.087309 1191.18468 0.624937102 -0.6782171 0.040512452 0.927001456 16.09479792 10.49150441 7803 protein tyrosine phosphatase 4A1 "GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005819,GO:0007049,GO:0007275,GO:0008138,GO:0009898,GO:0030335,GO:0035335" protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|early endosome|endoplasmic reticulum|spindle|cell cycle|multicellular organism development|protein tyrosine/serine/threonine phosphatase activity|cytoplasmic side of plasma membrane|positive regulation of cell migration|peptidyl-tyrosine dephosphorylation PTP4A2 3064.197337 2999.194887 3129.199787 1.0433466 0.061218501 0.848221355 1 36.30464639 39.50997417 8073 protein tyrosine phosphatase 4A2 "GO:0004725,GO:0004727,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0035335,GO:0043687" protein tyrosine phosphatase activity|prenylated protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|early endosome|cytosol|plasma membrane|peptidyl-tyrosine dephosphorylation|post-translational protein modification PTP4A3 7.089846003 13.19442759 0.985264417 0.074672767 -3.743273999 0.05299914 1 0.186610223 0.014534952 11156 protein tyrosine phosphatase 4A3 "GO:0004725,GO:0004727,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005886,GO:0006355,GO:0008138,GO:0035335,GO:0043542,GO:1901224,GO:1904951" "protein tyrosine phosphatase activity|prenylated protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|early endosome|plasma membrane|regulation of transcription, DNA-templated|protein tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|endothelial cell migration|positive regulation of NIK/NF-kappaB signaling|positive regulation of establishment of protein localization" PTPA 3511.06696 3642.67697 3379.456949 0.92773995 -0.108207628 0.734244152 1 58.77309269 56.87491128 5524 protein phosphatase 2 phosphatase activator "GO:0000159,GO:0000413,GO:0003755,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0007052,GO:0008160,GO:0016887,GO:0019888,GO:0032515,GO:0032516,GO:0034704,GO:0035307,GO:0035308,GO:0042803,GO:0043065,GO:0043666,GO:0051721,GO:0070062" protein phosphatase type 2A complex|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|signaling receptor binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitotic spindle organization|protein tyrosine phosphatase activator activity|ATPase activity|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|positive regulation of phosphoprotein phosphatase activity|calcium channel complex|positive regulation of protein dephosphorylation|negative regulation of protein dephosphorylation|protein homodimerization activity|positive regulation of apoptotic process|regulation of phosphoprotein phosphatase activity|protein phosphatase 2A binding|extracellular exosome hsa04931 Insulin resistance PTPDC1 759.9610207 628.2577444 891.664297 1.41926511 0.505144102 0.173811138 1 3.489694933 5.166148898 138639 protein tyrosine phosphatase domain containing 1 "GO:0004725,GO:0005515,GO:0005654,GO:0005737,GO:0008138,GO:0035335,GO:0060271" protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|protein tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|cilium assembly PTPMT1 844.6207694 791.6656553 897.5758835 1.133781512 0.181142649 0.619663346 1 16.28556971 19.25964404 114971 protein tyrosine phosphatase mitochondrial 1 "GO:0004439,GO:0004725,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0008138,GO:0008962,GO:0032049,GO:0035335,GO:0106306,GO:0106307,GO:2001242" "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|protein tyrosine/serine/threonine phosphatase activity|phosphatidylglycerophosphatase activity|cardiolipin biosynthetic process|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity|regulation of intrinsic apoptotic signaling pathway" PTPN1 2741.031846 3167.677577 2314.386114 0.730625532 -0.452795925 0.155455239 1 40.31960151 30.7274843 5770 protein tyrosine phosphatase non-receptor type 1 "GO:0003723,GO:0004725,GO:0005158,GO:0005515,GO:0005759,GO:0005769,GO:0005783,GO:0005829,GO:0005886,GO:0006470,GO:0007257,GO:0008270,GO:0008286,GO:0009966,GO:0009968,GO:0019899,GO:0019901,GO:0030061,GO:0030100,GO:0030948,GO:0030968,GO:0030971,GO:0031532,GO:0032991,GO:0033157,GO:0034620,GO:0035335,GO:0035791,GO:0036498,GO:0043407,GO:0045296,GO:0046627,GO:0046875,GO:0051721,GO:0060338,GO:0060397,GO:0061098,GO:0070373,GO:0097443,GO:0098554,GO:1902202,GO:1902236,GO:1903896,GO:1903898,GO:1990264,GO:2000646" RNA binding|protein tyrosine phosphatase activity|insulin receptor binding|protein binding|mitochondrial matrix|early endosome|endoplasmic reticulum|cytosol|plasma membrane|protein dephosphorylation|activation of JUN kinase activity|zinc ion binding|insulin receptor signaling pathway|regulation of signal transduction|negative regulation of signal transduction|enzyme binding|protein kinase binding|mitochondrial crista|regulation of endocytosis|negative regulation of vascular endothelial growth factor receptor signaling pathway|endoplasmic reticulum unfolded protein response|receptor tyrosine kinase binding|actin cytoskeleton reorganization|protein-containing complex|regulation of intracellular protein transport|cellular response to unfolded protein|peptidyl-tyrosine dephosphorylation|platelet-derived growth factor receptor-beta signaling pathway|IRE1-mediated unfolded protein response|negative regulation of MAP kinase activity|cadherin binding|negative regulation of insulin receptor signaling pathway|ephrin receptor binding|protein phosphatase 2A binding|regulation of type I interferon-mediated signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|positive regulation of protein tyrosine kinase activity|negative regulation of ERK1 and ERK2 cascade|sorting endosome|cytoplasmic side of endoplasmic reticulum membrane|regulation of hepatocyte growth factor receptor signaling pathway|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of IRE1-mediated unfolded protein response|negative regulation of PERK-mediated unfolded protein response|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity|positive regulation of receptor catabolic process "hsa04520,hsa04910,hsa04931" Adherens junction|Insulin signaling pathway|Insulin resistance PTPN11 6103.466148 5978.090654 6228.841641 1.041944996 0.05927912 0.855515924 1 47.22651726 51.32708999 5781 protein tyrosine phosphatase non-receptor type 11 "GO:0000077,GO:0000187,GO:0001784,GO:0004721,GO:0004725,GO:0004726,GO:0005158,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006641,GO:0007173,GO:0007229,GO:0007411,GO:0007420,GO:0007507,GO:0008543,GO:0009755,GO:0019221,GO:0019901,GO:0019904,GO:0021697,GO:0030159,GO:0030168,GO:0030220,GO:0030971,GO:0031295,GO:0031748,GO:0032331,GO:0032528,GO:0032728,GO:0032755,GO:0032760,GO:0032991,GO:0033277,GO:0033628,GO:0033629,GO:0035264,GO:0035265,GO:0035335,GO:0035855,GO:0036302,GO:0038127,GO:0042445,GO:0042593,GO:0043254,GO:0043274,GO:0043560,GO:0045296,GO:0045778,GO:0045931,GO:0046326,GO:0046628,GO:0046676,GO:0046825,GO:0046887,GO:0048008,GO:0048011,GO:0048013,GO:0048609,GO:0048806,GO:0048839,GO:0048873,GO:0050731,GO:0050839,GO:0050900,GO:0051428,GO:0051463,GO:0051897,GO:0060020,GO:0060125,GO:0060325,GO:0060338,GO:0061582,GO:0070102,GO:0070374,GO:0071260,GO:0071345,GO:0071364,GO:1990782" DNA damage checkpoint|activation of MAPK activity|phosphotyrosine residue binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|insulin receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|triglyceride metabolic process|epidermal growth factor receptor signaling pathway|integrin-mediated signaling pathway|axon guidance|brain development|heart development|fibroblast growth factor receptor signaling pathway|hormone-mediated signaling pathway|cytokine-mediated signaling pathway|protein kinase binding|protein domain specific binding|cerebellar cortex formation|signaling receptor complex adaptor activity|platelet activation|platelet formation|receptor tyrosine kinase binding|T cell costimulation|D1 dopamine receptor binding|negative regulation of chondrocyte differentiation|microvillus organization|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|protein-containing complex|abortive mitotic cell cycle|regulation of cell adhesion mediated by integrin|negative regulation of cell adhesion mediated by integrin|multicellular organism growth|organ growth|peptidyl-tyrosine dephosphorylation|megakaryocyte development|atrioventricular canal development|ERBB signaling pathway|hormone metabolic process|glucose homeostasis|regulation of protein-containing complex assembly|phospholipase binding|insulin receptor substrate binding|cadherin binding|positive regulation of ossification|positive regulation of mitotic cell cycle|positive regulation of glucose import|positive regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|regulation of protein export from nucleus|positive regulation of hormone secretion|platelet-derived growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|ephrin receptor signaling pathway|multicellular organismal reproductive process|genitalia development|inner ear development|homeostasis of number of cells within a tissue|positive regulation of peptidyl-tyrosine phosphorylation|cell adhesion molecule binding|leukocyte migration|peptide hormone receptor binding|negative regulation of cortisol secretion|positive regulation of protein kinase B signaling|Bergmann glial cell differentiation|negative regulation of growth hormone secretion|face morphogenesis|regulation of type I interferon-mediated signaling pathway|intestinal epithelial cell migration|interleukin-6-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to mechanical stimulus|cellular response to cytokine stimulus|cellular response to epidermal growth factor stimulus|protein tyrosine kinase binding "hsa04014,hsa04072,hsa04360,hsa04625,hsa04630,hsa04650,hsa04670,hsa04722,hsa04920,hsa04931,hsa05120,hsa05130,hsa05168,hsa05205,hsa05211,hsa05220,hsa05235" Ras signaling pathway|Phospholipase D signaling pathway|Axon guidance|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Insulin resistance|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Herpes simplex virus 1 infection|Proteoglycans in cancer|Renal cell carcinoma|Chronic myeloid leukemia|PD-L1 expression and PD-1 checkpoint pathway in cancer PTPN12 3589.527855 3483.328883 3695.726826 1.060975564 0.085391429 0.789001083 1 49.52788307 54.81142295 5782 protein tyrosine phosphatase non-receptor type 12 "GO:0002102,GO:0004721,GO:0004725,GO:0004726,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005925,GO:0006470,GO:0017124,GO:0035335,GO:0038128,GO:0042058,GO:0042246,GO:0042995,GO:0071345,GO:0071364,GO:1901185,GO:2000587" podosome|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|focal adhesion|protein dephosphorylation|SH3 domain binding|peptidyl-tyrosine dephosphorylation|ERBB2 signaling pathway|regulation of epidermal growth factor receptor signaling pathway|tissue regeneration|cell projection|cellular response to cytokine stimulus|cellular response to epidermal growth factor stimulus|negative regulation of ERBB signaling pathway|negative regulation of platelet-derived growth factor receptor-beta signaling pathway PTPN13 592.3581901 486.1639089 698.5524713 1.436866165 0.52292569 0.182590304 1 2.877803518 4.313138332 5783 protein tyrosine phosphatase non-receptor type 13 "GO:0001650,GO:0001933,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006470,GO:0006661,GO:0014066,GO:0030027,GO:0035335,GO:0036312,GO:0043005,GO:0044297,GO:0070062,GO:0071345" fibrillar center|negative regulation of protein phosphorylation|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|protein dephosphorylation|phosphatidylinositol biosynthetic process|regulation of phosphatidylinositol 3-kinase signaling|lamellipodium|peptidyl-tyrosine dephosphorylation|phosphatidylinositol 3-kinase regulatory subunit binding|neuron projection|cell body|extracellular exosome|cellular response to cytokine stimulus hsa04210 Apoptosis PTPN14 4273.397615 4870.773692 3676.021538 0.754709985 -0.406005734 0.203788818 1 18.15347005 14.2907716 5784 protein tyrosine phosphatase non-receptor type 14 "GO:0001946,GO:0003712,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005856,GO:0006355,GO:0006470,GO:0008285,GO:0030971,GO:0035335,GO:0046825,GO:0071345" "lymphangiogenesis|transcription coregulator activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytoskeleton|regulation of transcription, DNA-templated|protein dephosphorylation|negative regulation of cell population proliferation|receptor tyrosine kinase binding|peptidyl-tyrosine dephosphorylation|regulation of protein export from nucleus|cellular response to cytokine stimulus" PTPN18 764.1759833 748.0225487 780.3294179 1.0431897 0.06100153 0.8725641 1 10.35101181 11.26320592 26469 protein tyrosine phosphatase non-receptor type 18 "GO:0001825,GO:0004725,GO:0004726,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0035335,GO:0038128,GO:0071345,GO:1901185" blastocyst formation|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|peptidyl-tyrosine dephosphorylation|ERBB2 signaling pathway|cellular response to cytokine stimulus|negative regulation of ERBB signaling pathway PTPN2 725.2486363 680.0204988 770.4767737 1.133019924 0.180173231 0.632504854 1 7.857777617 9.286524531 5771 protein tyrosine phosphatase non-receptor type 2 "GO:0000122,GO:0004725,GO:0004726,GO:0005178,GO:0005515,GO:0005654,GO:0005783,GO:0005793,GO:0005829,GO:0005886,GO:0008285,GO:0008286,GO:0010804,GO:0010888,GO:0019901,GO:0019905,GO:0030183,GO:0030217,GO:0030218,GO:0030971,GO:0035335,GO:0042059,GO:0042532,GO:0042593,GO:0045650,GO:0045722,GO:0046627,GO:0050728,GO:0050860,GO:0050922,GO:0060334,GO:0060336,GO:0060339,GO:0061099,GO:0070104,GO:0070373,GO:0071345,GO:0097677,GO:1902202,GO:1902206,GO:1902215,GO:1902227,GO:1902233,GO:1902237,GO:1903899,GO:2000587" negative regulation of transcription by RNA polymerase II|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|integrin binding|protein binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|negative regulation of cell population proliferation|insulin receptor signaling pathway|negative regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of lipid storage|protein kinase binding|syntaxin binding|B cell differentiation|T cell differentiation|erythrocyte differentiation|receptor tyrosine kinase binding|peptidyl-tyrosine dephosphorylation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of tyrosine phosphorylation of STAT protein|glucose homeostasis|negative regulation of macrophage differentiation|positive regulation of gluconeogenesis|negative regulation of insulin receptor signaling pathway|negative regulation of inflammatory response|negative regulation of T cell receptor signaling pathway|negative regulation of chemotaxis|regulation of interferon-gamma-mediated signaling pathway|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of type I interferon-mediated signaling pathway|negative regulation of protein tyrosine kinase activity|negative regulation of interleukin-6-mediated signaling pathway|negative regulation of ERK1 and ERK2 cascade|cellular response to cytokine stimulus|STAT family protein binding|regulation of hepatocyte growth factor receptor signaling pathway|negative regulation of interleukin-2-mediated signaling pathway|negative regulation of interleukin-4-mediated signaling pathway|negative regulation of macrophage colony-stimulating factor signaling pathway|negative regulation of positive thymic T cell selection|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of PERK-mediated unfolded protein response|negative regulation of platelet-derived growth factor receptor-beta signaling pathway hsa04630 JAK-STAT signaling pathway PTPN21 806.0551642 681.0354548 931.0748736 1.367145964 0.451167282 0.218894177 1 4.763436436 6.792836929 11099 protein tyrosine phosphatase non-receptor type 21 "GO:0004725,GO:0005515,GO:0005737,GO:0005856,GO:0006470,GO:0035335" protein tyrosine phosphatase activity|protein binding|cytoplasm|cytoskeleton|protein dephosphorylation|peptidyl-tyrosine dephosphorylation PTPN22 8.030573092 10.14955968 5.911586499 0.582447582 -0.779799875 0.654071524 1 0.092386663 0.056128322 26191 protein tyrosine phosphatase non-receptor type 22 "GO:0002230,GO:0004725,GO:0004726,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0006914,GO:0009898,GO:0010507,GO:0010628,GO:0010629,GO:0016791,GO:0017124,GO:0019900,GO:0030217,GO:0031625,GO:0031663,GO:0032481,GO:0032496,GO:0032715,GO:0032717,GO:0032720,GO:0032729,GO:0032817,GO:0034141,GO:0034145,GO:0034157,GO:0034165,GO:0035335,GO:0035644,GO:0043508,GO:0045088,GO:0048471,GO:0050852,GO:0050855,GO:0050860,GO:0050868,GO:0070374,GO:0070433,GO:0071225,GO:0071663,GO:1901222,GO:1902523,GO:1903753,GO:2000566" "positive regulation of defense response to virus by host|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|cytosol|protein dephosphorylation|autophagy|cytoplasmic side of plasma membrane|negative regulation of autophagy|positive regulation of gene expression|negative regulation of gene expression|phosphatase activity|SH3 domain binding|kinase binding|T cell differentiation|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|positive regulation of type I interferon production|response to lipopolysaccharide|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of tumor necrosis factor production|positive regulation of interferon-gamma production|regulation of natural killer cell proliferation|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of toll-like receptor 7 signaling pathway|positive regulation of toll-like receptor 9 signaling pathway|peptidyl-tyrosine dephosphorylation|phosphoanandamide dephosphorylation|negative regulation of JUN kinase activity|regulation of innate immune response|perinuclear region of cytoplasm|T cell receptor signaling pathway|regulation of B cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|negative regulation of T cell activation|positive regulation of ERK1 and ERK2 cascade|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to muramyl dipeptide|positive regulation of granzyme B production|regulation of NIK/NF-kappaB signaling|positive regulation of protein K63-linked ubiquitination|negative regulation of p38MAPK cascade|positive regulation of CD8-positive, alpha-beta T cell proliferation" PTPN23 1585.458209 1426.013136 1744.903282 1.223623569 0.2911598 0.376848215 1 13.73835546 17.53470695 25930 protein tyrosine phosphatase non-receptor type 23 "GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0010633,GO:0015031,GO:0016604,GO:0019901,GO:0032456,GO:0035335,GO:0036064,GO:0043162,GO:0043231,GO:0045022,GO:0060271,GO:0061357,GO:0070062,GO:0071345,GO:1903387,GO:1903393,GO:2000643" protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|endosome|early endosome|cytosol|negative regulation of epithelial cell migration|protein transport|nuclear body|protein kinase binding|endocytic recycling|peptidyl-tyrosine dephosphorylation|ciliary basal body|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|early endosome to late endosome transport|cilium assembly|positive regulation of Wnt protein secretion|extracellular exosome|cellular response to cytokine stimulus|positive regulation of homophilic cell adhesion|positive regulation of adherens junction organization|positive regulation of early endosome to late endosome transport PTPN3 1294.526104 1002.776497 1586.275711 1.581883616 0.66164346 0.050933106 1 4.556939612 7.519063129 5774 protein tyrosine phosphatase non-receptor type 3 "GO:0001784,GO:0004725,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0006470,GO:0008092,GO:0009898,GO:0017080,GO:0035335,GO:0042059,GO:0045930,GO:0051045,GO:0051117,GO:0097421,GO:0098902,GO:2000649" phosphotyrosine residue binding|protein tyrosine phosphatase activity|protein binding|cytoplasm|cytoskeleton|plasma membrane|protein dephosphorylation|cytoskeletal protein binding|cytoplasmic side of plasma membrane|sodium channel regulator activity|peptidyl-tyrosine dephosphorylation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of mitotic cell cycle|negative regulation of membrane protein ectodomain proteolysis|ATPase binding|liver regeneration|regulation of membrane depolarization during action potential|regulation of sodium ion transmembrane transporter activity PTPN4 206.6637896 219.2304892 194.0970901 0.885356279 -0.175669964 0.748185182 1 1.001194849 0.924597272 5775 protein tyrosine phosphatase non-receptor type 4 "GO:0004725,GO:0004726,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006470,GO:0008092,GO:0009898,GO:0035335,GO:0071345" protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein dephosphorylation|cytoskeletal protein binding|cytoplasmic side of plasma membrane|peptidyl-tyrosine dephosphorylation|cellular response to cytokine stimulus PTPN6 103.3406785 93.37594909 113.3054079 1.213432463 0.279093814 0.685738156 1 1.812634117 2.294255012 5777 protein tyrosine phosphatase non-receptor type 6 "GO:0001784,GO:0002244,GO:0002924,GO:0004725,GO:0005001,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005911,GO:0006470,GO:0007186,GO:0008284,GO:0008285,GO:0014068,GO:0016020,GO:0017124,GO:0018108,GO:0019221,GO:0019901,GO:0030154,GO:0030168,GO:0030220,GO:0031295,GO:0032715,GO:0032720,GO:0032991,GO:0033277,GO:0033630,GO:0035335,GO:0035556,GO:0035580,GO:0035855,GO:0042105,GO:0042130,GO:0042169,GO:0042267,GO:0042981,GO:0043312,GO:0043407,GO:0045577,GO:0050732,GO:0050839,GO:0050853,GO:0050860,GO:0050900,GO:0051279,GO:0060338,GO:0070062,GO:0070372,GO:0070527,GO:0071345,GO:0140031,GO:1904724,GO:1905867,GO:2000045" phosphotyrosine residue binding|hematopoietic progenitor cell differentiation|negative regulation of humoral immune response mediated by circulating immunoglobulin|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|cell-cell junction|protein dephosphorylation|G protein-coupled receptor signaling pathway|positive regulation of cell population proliferation|negative regulation of cell population proliferation|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|SH3 domain binding|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|protein kinase binding|cell differentiation|platelet activation|platelet formation|T cell costimulation|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|protein-containing complex|abortive mitotic cell cycle|positive regulation of cell adhesion mediated by integrin|peptidyl-tyrosine dephosphorylation|intracellular signal transduction|specific granule lumen|megakaryocyte development|alpha-beta T cell receptor complex|negative regulation of T cell proliferation|SH2 domain binding|natural killer cell mediated cytotoxicity|regulation of apoptotic process|neutrophil degranulation|negative regulation of MAP kinase activity|regulation of B cell differentiation|negative regulation of peptidyl-tyrosine phosphorylation|cell adhesion molecule binding|B cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|leukocyte migration|regulation of release of sequestered calcium ion into cytosol|regulation of type I interferon-mediated signaling pathway|extracellular exosome|regulation of ERK1 and ERK2 cascade|platelet aggregation|cellular response to cytokine stimulus|phosphorylation-dependent protein binding|tertiary granule lumen|epididymis development|regulation of G1/S transition of mitotic cell cycle "hsa04520,hsa04630,hsa04650,hsa04660,hsa04662,hsa05130,hsa05140,hsa05205,hsa05235" Adherens junction|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Pathogenic Escherichia coli infection|Leishmaniasis|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer PTPN9 2913.28734 2819.54768 3007.026999 1.066492693 0.092874082 0.771099448 1 18.21662753 20.26477531 5780 protein tyrosine phosphatase non-receptor type 9 "GO:0004725,GO:0004726,GO:0005515,GO:0005654,GO:0005737,GO:0006470,GO:0010977,GO:0035335,GO:0044306,GO:0071345,GO:1903078" protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|protein dephosphorylation|negative regulation of neuron projection development|peptidyl-tyrosine dephosphorylation|neuron projection terminus|cellular response to cytokine stimulus|positive regulation of protein localization to plasma membrane PTPRA 3879.542489 3439.685777 4319.399202 1.255754008 0.32855388 0.302509184 1 40.30725361 52.79632709 5786 protein tyrosine phosphatase receptor type A "GO:0000165,GO:0004725,GO:0005001,GO:0005515,GO:0005886,GO:0005887,GO:0005925,GO:0006468,GO:0006470,GO:0007229,GO:0007411,GO:0008286,GO:0016020,GO:0035335,GO:0043235,GO:0050804,GO:0051893,GO:0070062,GO:0098685,GO:0099699" MAPK cascade|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|plasma membrane|integral component of plasma membrane|focal adhesion|protein phosphorylation|protein dephosphorylation|integrin-mediated signaling pathway|axon guidance|insulin receptor signaling pathway|membrane|peptidyl-tyrosine dephosphorylation|receptor complex|modulation of chemical synaptic transmission|regulation of focal adhesion assembly|extracellular exosome|Schaffer collateral - CA1 synapse|integral component of synaptic membrane PTPRB 47.80957255 69.01700585 26.60213925 0.385443253 -1.37540962 0.112766451 1 0.264748002 0.10644103 5787 protein tyrosine phosphatase receptor type B "GO:0001525,GO:0005001,GO:0005515,GO:0005886,GO:0005887,GO:0006470,GO:0006796,GO:0016311,GO:0035579,GO:0043235,GO:0043312,GO:0045296,GO:0070821,GO:1990264" angiogenesis|transmembrane receptor protein tyrosine phosphatase activity|protein binding|plasma membrane|integral component of plasma membrane|protein dephosphorylation|phosphate-containing compound metabolic process|dephosphorylation|specific granule membrane|receptor complex|neutrophil degranulation|cadherin binding|tertiary granule membrane|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity hsa04520 Adherens junction PTPRE 454.9489387 421.2067269 488.6911506 1.160216871 0.214394503 0.610948528 1 2.44136356 2.954524285 5791 protein tyrosine phosphatase receptor type E "GO:0004725,GO:0005001,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0006470,GO:0016021,GO:0035335,GO:0046627" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|plasma membrane|protein dephosphorylation|integral component of membrane|peptidyl-tyrosine dephosphorylation|negative regulation of insulin receptor signaling pathway PTPRF 14319.22193 13766.86276 14871.5811 1.080244742 0.111358209 0.749416656 1 92.38678044 104.0993274 5792 protein tyrosine phosphatase receptor type F "GO:0004725,GO:0005001,GO:0005886,GO:0005887,GO:0006470,GO:0007155,GO:0007185,GO:0008201,GO:0016477,GO:0031102,GO:0035335,GO:0035373,GO:0043005,GO:0043025,GO:0044877,GO:0048679,GO:0050839,GO:0070062,GO:0099560,GO:1900121" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|plasma membrane|integral component of plasma membrane|protein dephosphorylation|cell adhesion|transmembrane receptor protein tyrosine phosphatase signaling pathway|heparin binding|cell migration|neuron projection regeneration|peptidyl-tyrosine dephosphorylation|chondroitin sulfate proteoglycan binding|neuron projection|neuronal cell body|protein-containing complex binding|regulation of axon regeneration|cell adhesion molecule binding|extracellular exosome|synaptic membrane adhesion|negative regulation of receptor binding "hsa04514,hsa04520,hsa04910,hsa04931" Cell adhesion molecules|Adherens junction|Insulin signaling pathway|Insulin resistance PTPRG 1317.787451 1515.329261 1120.245642 0.739275398 -0.435816192 0.196523802 1 7.181927877 5.538130978 5793 protein tyrosine phosphatase receptor type G "GO:0004725,GO:0005001,GO:0005515,GO:0005887,GO:0006470,GO:0007169,GO:0007420,GO:0010633,GO:0010977,GO:0035335,GO:0042802,GO:0070062,GO:1903385" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|integral component of plasma membrane|protein dephosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|brain development|negative regulation of epithelial cell migration|negative regulation of neuron projection development|peptidyl-tyrosine dephosphorylation|identical protein binding|extracellular exosome|regulation of homophilic cell adhesion PTPRH 248.5348057 252.7240361 244.3455753 0.966847392 -0.048639903 0.93111771 1 2.88084197 2.905315462 5794 protein tyrosine phosphatase receptor type H "GO:0004725,GO:0005001,GO:0005515,GO:0005737,GO:0005887,GO:0006470,GO:0006915,GO:0016324,GO:0031528,GO:0035335,GO:0045296" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|cytoplasm|integral component of plasma membrane|protein dephosphorylation|apoptotic process|apical plasma membrane|microvillus membrane|peptidyl-tyrosine dephosphorylation|cadherin binding PTPRJ 2545.791385 3459.984896 1631.597874 0.471562138 -1.084480208 0.000760693 0.079140395 18.21201714 8.958038152 5795 protein tyrosine phosphatase receptor type J "GO:0001772,GO:0004725,GO:0005161,GO:0005515,GO:0005886,GO:0005887,GO:0005911,GO:0006470,GO:0008013,GO:0008285,GO:0009986,GO:0010642,GO:0016791,GO:0019901,GO:0030155,GO:0030183,GO:0030308,GO:0030336,GO:0032587,GO:0032760,GO:0035335,GO:0035579,GO:0035584,GO:0042059,GO:0043116,GO:0043312,GO:0043407,GO:0043410,GO:0045295,GO:0045296,GO:0045785,GO:0048008,GO:0050731,GO:0050852,GO:0050860,GO:0050918,GO:0051019,GO:0051894,GO:0051897,GO:0051898,GO:0060242,GO:0070062,GO:0070097,GO:1905451" immunological synapse|protein tyrosine phosphatase activity|platelet-derived growth factor receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell-cell junction|protein dephosphorylation|beta-catenin binding|negative regulation of cell population proliferation|cell surface|negative regulation of platelet-derived growth factor receptor signaling pathway|phosphatase activity|protein kinase binding|regulation of cell adhesion|B cell differentiation|negative regulation of cell growth|negative regulation of cell migration|ruffle membrane|positive regulation of tumor necrosis factor production|peptidyl-tyrosine dephosphorylation|specific granule membrane|calcium-mediated signaling using intracellular calcium source|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of vascular permeability|neutrophil degranulation|negative regulation of MAP kinase activity|positive regulation of MAPK cascade|gamma-catenin binding|cadherin binding|positive regulation of cell adhesion|platelet-derived growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|T cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|positive chemotaxis|mitogen-activated protein kinase binding|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of protein kinase B signaling|contact inhibition|extracellular exosome|delta-catenin binding|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis hsa04520 Adherens junction PTPRK 1426.034163 1674.677348 1177.390978 0.703055415 -0.508289688 0.127994025 1 10.26212943 7.525631958 5796 protein tyrosine phosphatase receptor type K "GO:0004725,GO:0005001,GO:0005515,GO:0005886,GO:0005887,GO:0005911,GO:0005912,GO:0006470,GO:0007155,GO:0007165,GO:0007179,GO:0008013,GO:0008285,GO:0009986,GO:0010839,GO:0016021,GO:0016477,GO:0019901,GO:0030054,GO:0030336,GO:0031256,GO:0034394,GO:0034614,GO:0034644,GO:0035335,GO:0043231,GO:0045295,GO:0045786,GO:0045892,GO:0048041" "protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|plasma membrane|integral component of plasma membrane|cell-cell junction|adherens junction|protein dephosphorylation|cell adhesion|signal transduction|transforming growth factor beta receptor signaling pathway|beta-catenin binding|negative regulation of cell population proliferation|cell surface|negative regulation of keratinocyte proliferation|integral component of membrane|cell migration|protein kinase binding|cell junction|negative regulation of cell migration|leading edge membrane|protein localization to cell surface|cellular response to reactive oxygen species|cellular response to UV|peptidyl-tyrosine dephosphorylation|intracellular membrane-bounded organelle|gamma-catenin binding|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|focal adhesion assembly" PTPRM 1260.958082 1301.173551 1220.742612 0.938185848 -0.092054356 0.787988498 1 9.268614644 9.070257853 5797 protein tyrosine phosphatase receptor type M "GO:0001937,GO:0004725,GO:0005001,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0005911,GO:0005912,GO:0006470,GO:0007156,GO:0007165,GO:0010596,GO:0010842,GO:0016525,GO:0030027,GO:0031175,GO:0031290,GO:0035335,GO:0042493,GO:0042802,GO:0045296,GO:0048471" negative regulation of endothelial cell proliferation|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|cell-cell junction|adherens junction|protein dephosphorylation|homophilic cell adhesion via plasma membrane adhesion molecules|signal transduction|negative regulation of endothelial cell migration|retina layer formation|negative regulation of angiogenesis|lamellipodium|neuron projection development|retinal ganglion cell axon guidance|peptidyl-tyrosine dephosphorylation|response to drug|identical protein binding|cadherin binding|perinuclear region of cytoplasm "hsa04514,hsa04520" Cell adhesion molecules|Adherens junction PTPRN 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.013889203 0.042191027 5798 protein tyrosine phosphatase receptor type N "GO:0000302,GO:0001553,GO:0004725,GO:0005515,GO:0005634,GO:0005768,GO:0005794,GO:0005886,GO:0008021,GO:0008134,GO:0016021,GO:0019221,GO:0030073,GO:0030141,GO:0030507,GO:0030658,GO:0032868,GO:0035335,GO:0035773,GO:0043025,GO:0043204,GO:0043627,GO:0043679,GO:0044389,GO:0045202,GO:0045944,GO:0051020,GO:0051591,GO:1904692,GO:1990502" response to reactive oxygen species|luteinization|protein tyrosine phosphatase activity|protein binding|nucleus|endosome|Golgi apparatus|plasma membrane|synaptic vesicle|transcription factor binding|integral component of membrane|cytokine-mediated signaling pathway|insulin secretion|secretory granule|spectrin binding|transport vesicle membrane|response to insulin|peptidyl-tyrosine dephosphorylation|insulin secretion involved in cellular response to glucose stimulus|neuronal cell body|perikaryon|response to estrogen|axon terminus|ubiquitin-like protein ligase binding|synapse|positive regulation of transcription by RNA polymerase II|GTPase binding|response to cAMP|positive regulation of type B pancreatic cell proliferation|dense core granule maturation hsa04940 Type I diabetes mellitus PTPRN2 270.9704791 270.9932436 270.9477146 0.999831992 -0.000242405 1 1 0.648071196 0.675873903 5799 protein tyrosine phosphatase receptor type N2 "GO:0005001,GO:0005788,GO:0005886,GO:0005887,GO:0006470,GO:0006629,GO:0007269,GO:0030285,GO:0030667,GO:0030672,GO:0034260,GO:0035335,GO:0035773,GO:0043195,GO:0043235,GO:0043312,GO:0101003" transmembrane receptor protein tyrosine phosphatase activity|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|protein dephosphorylation|lipid metabolic process|neurotransmitter secretion|integral component of synaptic vesicle membrane|secretory granule membrane|synaptic vesicle membrane|negative regulation of GTPase activity|peptidyl-tyrosine dephosphorylation|insulin secretion involved in cellular response to glucose stimulus|terminal bouton|receptor complex|neutrophil degranulation|ficolin-1-rich granule membrane hsa04940 Type I diabetes mellitus PTPRR 10.59765456 17.25425146 3.941057666 0.228410817 -2.130297123 0.136104822 1 0.215026321 0.051229984 5801 protein tyrosine phosphatase receptor type R "GO:0001701,GO:0004725,GO:0005001,GO:0005515,GO:0005615,GO:0005829,GO:0005886,GO:0006470,GO:0010633,GO:0016021,GO:0019901,GO:0030054,GO:0035335,GO:0038128,GO:0048471,GO:0070373,GO:1903385" in utero embryonic development|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|extracellular space|cytosol|plasma membrane|protein dephosphorylation|negative regulation of epithelial cell migration|integral component of membrane|protein kinase binding|cell junction|peptidyl-tyrosine dephosphorylation|ERBB2 signaling pathway|perinuclear region of cytoplasm|negative regulation of ERK1 and ERK2 cascade|regulation of homophilic cell adhesion hsa04010 MAPK signaling pathway PTPRS 996.3730163 894.1762081 1098.569824 1.228583152 0.296995505 0.399994353 1 5.968222256 7.648309836 5802 protein tyrosine phosphatase receptor type S "GO:0004721,GO:0004725,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0006470,GO:0008201,GO:0010977,GO:0021510,GO:0021549,GO:0021766,GO:0021987,GO:0022038,GO:0030285,GO:0030424,GO:0030426,GO:0030517,GO:0032687,GO:0032688,GO:0034164,GO:0035335,GO:0035374,GO:0043204,GO:0043395,GO:0048671,GO:0048681,GO:0050804,GO:0061000,GO:0070062,GO:0090557,GO:0098685,GO:0098978,GO:0099056,GO:0099061,GO:0099151,GO:0099560" phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytosol|plasma membrane|integral component of plasma membrane|protein dephosphorylation|heparin binding|negative regulation of neuron projection development|spinal cord development|cerebellum development|hippocampus development|cerebral cortex development|corpus callosum development|integral component of synaptic vesicle membrane|axon|growth cone|negative regulation of axon extension|negative regulation of interferon-alpha production|negative regulation of interferon-beta production|negative regulation of toll-like receptor 9 signaling pathway|peptidyl-tyrosine dephosphorylation|chondroitin sulfate binding|perikaryon|heparan sulfate proteoglycan binding|negative regulation of collateral sprouting|negative regulation of axon regeneration|modulation of chemical synaptic transmission|negative regulation of dendritic spine development|extracellular exosome|establishment of endothelial intestinal barrier|Schaffer collateral - CA1 synapse|glutamatergic synapse|integral component of presynaptic membrane|integral component of postsynaptic density membrane|regulation of postsynaptic density assembly|synaptic membrane adhesion PTPRU 2374.363787 2989.045327 1759.682248 0.58871046 -0.764369835 0.017185775 0.570200991 26.35984696 16.1867838 10076 protein tyrosine phosphatase receptor type U "GO:0004725,GO:0005001,GO:0005515,GO:0005886,GO:0005887,GO:0005911,GO:0006470,GO:0007155,GO:0007185,GO:0008013,GO:0008285,GO:0030154,GO:0030336,GO:0031100,GO:0034109,GO:0034394,GO:0035335,GO:0051384,GO:0090090,GO:2000049" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|plasma membrane|integral component of plasma membrane|cell-cell junction|protein dephosphorylation|cell adhesion|transmembrane receptor protein tyrosine phosphatase signaling pathway|beta-catenin binding|negative regulation of cell population proliferation|cell differentiation|negative regulation of cell migration|animal organ regeneration|homotypic cell-cell adhesion|protein localization to cell surface|peptidyl-tyrosine dephosphorylation|response to glucocorticoid|negative regulation of canonical Wnt signaling pathway|positive regulation of cell-cell adhesion mediated by cadherin PTPRZ1 3.463271234 1.014955968 5.911586499 5.824475823 2.542128219 0.321345721 1 0.009136854 0.055509773 5803 protein tyrosine phosphatase receptor type Z1 "GO:0004725,GO:0005001,GO:0005178,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006470,GO:0007417,GO:0007611,GO:0019221,GO:0031226,GO:0031641,GO:0035335,GO:0043524,GO:0048709,GO:0048714,GO:0070445" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|integrin binding|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|protein dephosphorylation|central nervous system development|learning or memory|cytokine-mediated signaling pathway|intrinsic component of plasma membrane|regulation of myelination|peptidyl-tyrosine dephosphorylation|negative regulation of neuron apoptotic process|oligodendrocyte differentiation|positive regulation of oligodendrocyte differentiation|regulation of oligodendrocyte progenitor proliferation hsa05120 Epithelial cell signaling in Helicobacter pylori infection PTRH1 266.9997298 268.9633316 265.0361281 0.98539874 -0.021220468 0.973956785 1 12.31649539 12.65945709 138428 peptidyl-tRNA hydrolase 1 homolog "GO:0003723,GO:0004045,GO:0005515" RNA binding|aminoacyl-tRNA hydrolase activity|protein binding PTRH2 492.7074288 544.016399 441.3984586 0.811369766 -0.30156855 0.46323624 1 12.25645527 10.37288672 51651 peptidyl-tRNA hydrolase 2 "GO:0004045,GO:0005515,GO:0005739,GO:0005829,GO:0006915,GO:0010629,GO:0016020,GO:2000210,GO:2000811" aminoacyl-tRNA hydrolase activity|protein binding|mitochondrion|cytosol|apoptotic process|negative regulation of gene expression|membrane|positive regulation of anoikis|negative regulation of anoikis PTRHD1 302.3180695 292.3073189 312.32882 1.068494697 0.095579747 0.845604181 1 13.21815581 14.73191375 391356 peptidyl-tRNA hydrolase domain containing 1 "GO:0004045,GO:0005515" aminoacyl-tRNA hydrolase activity|protein binding PTS 398.9994295 401.9225635 396.0762955 0.985454243 -0.02113921 0.967475198 1 23.34399076 23.99537249 5805 6-pyruvoyltetrahydropterin synthase "GO:0003874,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006520,GO:0006729,GO:0007417,GO:0042802,GO:0046872" 6-pyruvoyltetrahydropterin synthase activity|protein binding|cytoplasm|mitochondrion|cytosol|cellular amino acid metabolic process|tetrahydrobiopterin biosynthetic process|central nervous system development|identical protein binding|metal ion binding hsa00790 Folate biosynthesis PTTG1 1994.766542 1724.41019 2265.122894 1.313563853 0.393486332 0.22234673 1 90.40920578 123.8738891 9232 "PTTG1 regulator of sister chromatid separation, securin" "GO:0004869,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006281,GO:0006511,GO:0007283,GO:0010951,GO:0017124,GO:0031145,GO:0045143,GO:0051276,GO:0051301,GO:2000816" cysteine-type endopeptidase inhibitor activity|protein binding|nucleus|cytoplasm|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|spermatogenesis|negative regulation of endopeptidase activity|SH3 domain binding|anaphase-promoting complex-dependent catabolic process|homologous chromosome segregation|chromosome organization|cell division|negative regulation of mitotic sister chromatid separation "hsa04110,hsa04114,hsa05166" Cell cycle|Oocyte meiosis|Human T-cell leukemia virus 1 infection PTTG1IP 5908.586191 6059.287131 5757.88525 0.950257865 -0.073609035 0.820655395 1 118.0313528 116.9916287 754 PTTG1 interacting protein "GO:0002039,GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006606,GO:0016020,GO:0016021,GO:0031398,GO:0043518,GO:0070062,GO:1902254,GO:1903364" "p53 binding|molecular_function|protein binding|nucleus|nucleoplasm|cytoplasm|protein import into nucleus|membrane|integral component of membrane|positive regulation of protein ubiquitination|negative regulation of DNA damage response, signal transduction by p53 class mediator|extracellular exosome|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of cellular protein catabolic process" PTX3 1358.622976 1983.223962 734.0219903 0.370115531 -1.433952418 2.75E-05 0.005742879 53.31385207 20.58227148 5806 pentraxin 3 "GO:0001550,GO:0001849,GO:0001872,GO:0001878,GO:0005515,GO:0005576,GO:0005615,GO:0006954,GO:0008228,GO:0030198,GO:0031012,GO:0035580,GO:0042802,GO:0043312,GO:0044793,GO:0044869,GO:0044871,GO:0045087,GO:0045429,GO:0046597,GO:0046790,GO:0050766,GO:1903016,GO:1903019,GO:1904724" ovarian cumulus expansion|complement component C1q complex binding|(1->3)-beta-D-glucan binding|response to yeast|protein binding|extracellular region|extracellular space|inflammatory response|opsonization|extracellular matrix organization|extracellular matrix|specific granule lumen|identical protein binding|neutrophil degranulation|negative regulation by host of viral process|negative regulation by host of viral exo-alpha-sialidase activity|negative regulation by host of viral glycoprotein metabolic process|innate immune response|positive regulation of nitric oxide biosynthetic process|negative regulation of viral entry into host cell|virion binding|positive regulation of phagocytosis|negative regulation of exo-alpha-sialidase activity|negative regulation of glycoprotein metabolic process|tertiary granule lumen PUF60 4768.347248 4827.130586 4709.563911 0.975644605 -0.035572378 0.912215095 1 63.20505043 64.32197325 22827 poly(U) binding splicing factor 60 "GO:0000380,GO:0000381,GO:0000398,GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0006376,GO:0006915,GO:0030054,GO:0042802,GO:0045296" "alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|DNA binding|RNA binding|protein binding|nucleoplasm|mRNA splice site selection|apoptotic process|cell junction|identical protein binding|cadherin binding" hsa03040 Spliceosome PUM1 2432.134376 2459.238311 2405.030441 0.977957455 -0.032156391 0.921038259 1 23.12938622 23.59391441 9698 pumilio RNA binding family member 1 "GO:0000932,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007283,GO:0008344,GO:0010494,GO:0010608,GO:0016441,GO:0035196,GO:0035198,GO:0043488,GO:0048863,GO:0051726,GO:0051983,GO:0060964,GO:0061157,GO:1900246,GO:2000637" P-body|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleoplasm|cytoplasm|cytosol|spermatogenesis|adult locomotory behavior|cytoplasmic stress granule|posttranscriptional regulation of gene expression|posttranscriptional gene silencing|production of miRNAs involved in gene silencing by miRNA|miRNA binding|regulation of mRNA stability|stem cell differentiation|regulation of cell cycle|regulation of chromosome segregation|regulation of gene silencing by miRNA|mRNA destabilization|positive regulation of RIG-I signaling pathway|positive regulation of gene silencing by miRNA hsa05017 Spinocerebellar ataxia PUM2 2694.673692 2322.219256 3067.128129 1.320774566 0.401384243 0.207946695 1 7.105190177 9.788594401 23369 pumilio RNA binding family member 2 "GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005737,GO:0005829,GO:0006417,GO:0010494,GO:0010608,GO:0031965,GO:0034063,GO:0035196,GO:0035198,GO:0043488,GO:0048471,GO:0051983,GO:0060964,GO:1900246,GO:2000637" RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|cytoplasm|cytosol|regulation of translation|cytoplasmic stress granule|posttranscriptional regulation of gene expression|nuclear membrane|stress granule assembly|production of miRNAs involved in gene silencing by miRNA|miRNA binding|regulation of mRNA stability|perinuclear region of cytoplasm|regulation of chromosome segregation|regulation of gene silencing by miRNA|positive regulation of RIG-I signaling pathway|positive regulation of gene silencing by miRNA hsa05017 Spinocerebellar ataxia PUM3 591.4659597 627.2427885 555.6891309 0.885923507 -0.174745957 0.658221108 1 14.52566733 13.42295854 9933 pumilio RNA binding family member 3 "GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005783,GO:0006417,GO:0010835" DNA binding|RNA binding|mRNA binding|protein binding|nucleoplasm|chromosome|nucleolus|endoplasmic reticulum|regulation of translation|regulation of protein ADP-ribosylation PURA 1138.921874 906.3556798 1371.488068 1.513189688 0.597592849 0.083566049 1 3.9878132 6.294251749 5813 purine rich element binding protein A "GO:0000122,GO:0000781,GO:0000900,GO:0000977,GO:0000981,GO:0003691,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0006268,GO:0006270,GO:0006357,GO:0007399,GO:0008134,GO:0008284,GO:0017148,GO:0030154,GO:0032422,GO:0032839,GO:0043025,GO:0046332,GO:0046651,GO:0050673,GO:0098794,GO:0098963,GO:0098978" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|translation repressor activity, mRNA regulatory element binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|double-stranded telomeric DNA binding|single-stranded DNA binding|RNA binding|protein binding|nucleus|DNA unwinding involved in DNA replication|DNA replication initiation|regulation of transcription by RNA polymerase II|nervous system development|transcription factor binding|positive regulation of cell population proliferation|negative regulation of translation|cell differentiation|purine-rich negative regulatory element binding|dendrite cytoplasm|neuronal cell body|SMAD binding|lymphocyte proliferation|epithelial cell proliferation|postsynapse|dendritic transport of messenger ribonucleoprotein complex|glutamatergic synapse" PURB 1883.485111 2536.374965 1230.595256 0.485178758 -1.043411706 0.001399813 0.112814853 13.91447619 7.041814338 5814 purine rich element binding protein B "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003697,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008134,GO:0008283,GO:0030154,GO:0032422,GO:0045637,GO:0046332" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|single-stranded DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|cell population proliferation|cell differentiation|purine-rich negative regulatory element binding|regulation of myeloid cell differentiation|SMAD binding" PURG 53.42424353 48.71788648 58.13060058 1.193208589 0.254846267 0.775904688 1 0.723150376 0.900038147 29942 purine rich element binding protein G "GO:0000977,GO:0000981,GO:0003723,GO:0005634,GO:0006357,GO:0032422" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|nucleus|regulation of transcription by RNA polymerase II|purine-rich negative regulatory element binding" PUS1 597.0306501 670.8858951 523.1754052 0.779827701 -0.358772692 0.359766889 1 13.9884742 11.37849791 80324 pseudouridine synthase 1 "GO:0000049,GO:0002153,GO:0003723,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0009982,GO:0031119,GO:0070902,GO:0106029,GO:1990481" tRNA binding|steroid receptor RNA activator RNA binding|RNA binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|pseudouridine synthase activity|tRNA pseudouridine synthesis|mitochondrial tRNA pseudouridine synthesis|tRNA pseudouridine synthase activity|mRNA pseudouridine synthesis PUS10 89.78723068 76.12169763 103.4527637 1.359044359 0.442592546 0.534105757 1 0.586356721 0.83121136 150962 pseudouridine synthase 10 "GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0009982,GO:0031053,GO:0031119,GO:0046872,GO:0070878,GO:0106029" protein binding|nucleus|cytoplasm|mitochondrion|pseudouridine synthase activity|primary miRNA processing|tRNA pseudouridine synthesis|metal ion binding|primary miRNA binding|tRNA pseudouridine synthase activity PUS3 185.7950876 207.0510175 164.5391576 0.794679299 -0.331555331 0.551663638 1 5.733408205 4.75248433 83480 pseudouridine synthase 3 "GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0006400,GO:0009982,GO:0031119,GO:0106029,GO:1990481" RNA binding|nucleus|cytoplasm|cytosol|tRNA modification|pseudouridine synthase activity|tRNA pseudouridine synthesis|tRNA pseudouridine synthase activity|mRNA pseudouridine synthesis PUS7 429.7813966 586.6445497 272.9182434 0.46521909 -1.104017798 0.009968101 0.419890621 8.450363164 4.100613438 54517 pseudouridine synthase 7 "GO:0001522,GO:0003723,GO:0005634,GO:0009982,GO:0017148,GO:0019899,GO:0031119,GO:1902036,GO:1990481,GO:2000380" pseudouridine synthesis|RNA binding|nucleus|pseudouridine synthase activity|negative regulation of translation|enzyme binding|tRNA pseudouridine synthesis|regulation of hematopoietic stem cell differentiation|mRNA pseudouridine synthesis|regulation of mesoderm development PUS7L 569.599869 580.5548139 558.6449242 0.962260429 -0.055500693 0.892727676 1 2.098569213 2.106356386 83448 pseudouridine synthase 7 like "GO:0001522,GO:0003723,GO:0005515,GO:0005634,GO:0009982" pseudouridine synthesis|RNA binding|protein binding|nucleus|pseudouridine synthase activity PUSL1 347.4121028 344.0700733 350.7541323 1.019426447 0.027757687 0.957904782 1 12.34131403 13.12300303 126789 pseudouridine synthase like 1 "GO:0003723,GO:0009982,GO:0031119,GO:0043231" RNA binding|pseudouridine synthase activity|tRNA pseudouridine synthesis|intracellular membrane-bounded organelle PVR 1676.599127 1561.002279 1792.195974 1.14810593 0.199255758 0.543188194 1 13.20736027 15.81662851 5817 PVR cell adhesion molecule "GO:0001618,GO:0002860,GO:0005515,GO:0005615,GO:0005737,GO:0005886,GO:0005912,GO:0005925,GO:0007156,GO:0007157,GO:0009986,GO:0016021,GO:0034332,GO:0038023,GO:0042271,GO:0045954,GO:0046718,GO:0050776,GO:0050839,GO:0060370" virus receptor activity|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|protein binding|extracellular space|cytoplasm|plasma membrane|adherens junction|focal adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell surface|integral component of membrane|adherens junction organization|signaling receptor activity|susceptibility to natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|viral entry into host cell|regulation of immune response|cell adhesion molecule binding|susceptibility to T cell mediated cytotoxicity hsa04514 Cell adhesion molecules PVRIG 5.956123827 3.044867905 8.867379749 2.912237912 1.542128219 0.403727794 1 0.097110716 0.294991797 79037 PVR related immunoglobulin domain containing "GO:0005515,GO:0005886,GO:0016021,GO:0019902,GO:0038023,GO:0050860" protein binding|plasma membrane|integral component of membrane|phosphatase binding|signaling receptor activity|negative regulation of T cell receptor signaling pathway PWP1 1871.530056 1954.805195 1788.254916 0.914799552 -0.128472436 0.692498354 1 37.03852862 35.34236425 11137 "PWP1 homolog, endonuclein" "GO:0005634,GO:0005694,GO:0005730,GO:0005794,GO:0006351,GO:0033140,GO:0034773,GO:0042254,GO:1901838,GO:1990889,GO:2000738" "nucleus|chromosome|nucleolus|Golgi apparatus|transcription, DNA-templated|negative regulation of peptidyl-serine phosphorylation of STAT protein|histone H4-K20 trimethylation|ribosome biogenesis|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|H4K20me3 modified histone binding|positive regulation of stem cell differentiation" PWP2 24.24017703 40.59823873 7.882115332 0.194149194 -2.364762376 0.032091451 0.801045165 0.579199315 0.117295017 5822 PWP2 small subunit processome component "GO:0000028,GO:0000462,GO:0003723,GO:0005654,GO:0006364,GO:0032040,GO:0034388" "ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|rRNA processing|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome" hsa03008 Ribosome biogenesis in eukaryotes PWWP2A 540.4333699 539.9565752 540.9101647 1.001766049 0.002545622 1 1 3.241689863 3.387300305 114825 PWWP domain containing 2A "GO:0003682,GO:0005515,GO:0005634,GO:0042393" chromatin binding|protein binding|nucleus|histone binding PWWP2B 52.09480466 58.86744617 45.32216316 0.769901977 -0.37725332 0.664819288 1 1.240710976 0.996373088 170394 PWWP domain containing 2B "GO:0005515,GO:0005654" protein binding|nucleoplasm PWWP3A 518.3864084 514.582676 522.1901408 1.014783756 0.021172331 0.963487672 1 3.587802478 3.797676454 84939 "PWWP domain containing 3A, DNA repair factor" "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006325,GO:0031491" protein binding|nucleus|nucleoplasm|cytosol|DNA repair|chromatin organization|nucleosome binding PXDC1 831.6490285 780.5011397 882.7969172 1.131064226 0.177680853 0.627496926 1 18.20802823 21.4815747 221749 PX domain containing 1 GO:0035091 phosphatidylinositol binding PXDN 952.5920922 1033.225176 871.9590086 0.843919631 -0.244822482 0.491595023 1 7.621498712 6.708993938 7837 peroxidasin "GO:0001960,GO:0004601,GO:0005152,GO:0005201,GO:0005576,GO:0005615,GO:0005783,GO:0006955,GO:0006979,GO:0019806,GO:0020037,GO:0030198,GO:0030199,GO:0042744,GO:0046872,GO:0055114,GO:0062023,GO:0070062,GO:0070831,GO:0098869" negative regulation of cytokine-mediated signaling pathway|peroxidase activity|interleukin-1 receptor antagonist activity|extracellular matrix structural constituent|extracellular region|extracellular space|endoplasmic reticulum|immune response|response to oxidative stress|bromide peroxidase activity|heme binding|extracellular matrix organization|collagen fibril organization|hydrogen peroxide catabolic process|metal ion binding|oxidation-reduction process|collagen-containing extracellular matrix|extracellular exosome|basement membrane assembly|cellular oxidant detoxification PXDNL 8.463822196 6.08973581 10.83790858 1.779700946 0.831634837 0.617753532 1 0.061586189 0.114326338 137902 peroxidasin like "GO:0004519,GO:0004601,GO:0005615,GO:0005737,GO:0006979,GO:0020037,GO:0042744,GO:0046872,GO:0055114,GO:0090305,GO:0098869" endonuclease activity|peroxidase activity|extracellular space|cytoplasm|response to oxidative stress|heme binding|hydrogen peroxide catabolic process|metal ion binding|oxidation-reduction process|nucleic acid phosphodiester bond hydrolysis|cellular oxidant detoxification PXK 464.1632145 377.5636202 550.7628088 1.458728488 0.54471138 0.191152368 1 2.49605344 3.797906541 54899 PX domain containing serine/threonine kinase like "GO:0000166,GO:0003779,GO:0004672,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006954,GO:0032780,GO:0032991,GO:0034451,GO:0035091,GO:0042391,GO:0043271,GO:0050804" nucleotide binding|actin binding|protein kinase activity|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|inflammatory response|negative regulation of ATPase activity|protein-containing complex|centriolar satellite|phosphatidylinositol binding|regulation of membrane potential|negative regulation of ion transport|modulation of chemical synaptic transmission PXMP2 324.6349766 302.4568786 346.8130746 1.146652958 0.197428817 0.672496414 1 15.79213804 18.88812539 5827 peroxisomal membrane protein 2 "GO:0005515,GO:0005737,GO:0005739,GO:0005778,GO:0008150,GO:0016020,GO:0016021,GO:0032991" protein binding|cytoplasm|mitochondrion|peroxisomal membrane|biological_process|membrane|integral component of membrane|protein-containing complex hsa04146 Peroxisome PXMP4 550.3508404 477.0293051 623.6723757 1.307408935 0.386710462 0.332923754 1 4.246019586 5.790410743 11264 peroxisomal membrane protein 4 "GO:0005515,GO:0005777,GO:0005778,GO:0008150,GO:0016021" protein binding|peroxisome|peroxisomal membrane|biological_process|integral component of membrane hsa04146 Peroxisome PXN 5059.405293 4619.064612 5499.745973 1.190662274 0.251764257 0.433363618 1 32.35227873 40.1799506 5829 paxillin "GO:0001725,GO:0003712,GO:0005515,GO:0005829,GO:0005875,GO:0005886,GO:0005911,GO:0005925,GO:0005938,GO:0006355,GO:0006936,GO:0007155,GO:0007160,GO:0007165,GO:0007172,GO:0007179,GO:0008013,GO:0017166,GO:0019903,GO:0030027,GO:0034446,GO:0034614,GO:0038191,GO:0043542,GO:0046872,GO:0048010,GO:0051496,GO:0060396" "stress fiber|transcription coregulator activity|protein binding|cytosol|microtubule associated complex|plasma membrane|cell-cell junction|focal adhesion|cell cortex|regulation of transcription, DNA-templated|muscle contraction|cell adhesion|cell-matrix adhesion|signal transduction|signal complex assembly|transforming growth factor beta receptor signaling pathway|beta-catenin binding|vinculin binding|protein phosphatase binding|lamellipodium|substrate adhesion-dependent cell spreading|cellular response to reactive oxygen species|neuropilin binding|endothelial cell migration|metal ion binding|vascular endothelial growth factor receptor signaling pathway|positive regulation of stress fiber assembly|growth hormone receptor signaling pathway" "hsa04062,hsa04370,hsa04510,hsa04670,hsa04810,hsa05100,hsa05131,hsa05135,hsa05163,hsa05165,hsa05170,hsa05203,hsa05205" Chemokine signaling pathway|VEGF signaling pathway|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Proteoglycans in cancer PXYLP1 131.2249977 113.6750685 148.7749269 1.308773585 0.388215536 0.534989601 1 1.429660093 1.951700824 92370 2-phosphoxylose phosphatase 1 "GO:0000139,GO:0005515,GO:0005794,GO:0006024,GO:0010909,GO:0016021,GO:0016311,GO:0016791,GO:0050650" Golgi membrane|protein binding|Golgi apparatus|glycosaminoglycan biosynthetic process|positive regulation of heparan sulfate proteoglycan biosynthetic process|integral component of membrane|dephosphorylation|phosphatase activity|chondroitin sulfate proteoglycan biosynthetic process PYCARD 411.8524042 404.9674314 418.737377 1.0340026 0.048239814 0.916379228 1 27.09401818 29.22207011 29108 PYD and CARD domain containing "GO:0000139,GO:0001773,GO:0002020,GO:0002218,GO:0002230,GO:0002277,GO:0002588,GO:0002821,GO:0005138,GO:0005515,GO:0005523,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0006915,GO:0006919,GO:0006954,GO:0007165,GO:0008385,GO:0008656,GO:0010506,GO:0010803,GO:0017024,GO:0019899,GO:0030838,GO:0031647,GO:0032088,GO:0032090,GO:0032688,GO:0032722,GO:0032729,GO:0032731,GO:0032733,GO:0032755,GO:0032757,GO:0032760,GO:0032991,GO:0033209,GO:0034774,GO:0035578,GO:0042104,GO:0042771,GO:0042802,GO:0042803,GO:0043025,GO:0043065,GO:0043087,GO:0043124,GO:0043280,GO:0043312,GO:0044325,GO:0044351,GO:0045087,GO:0046330,GO:0046983,GO:0050727,GO:0050766,GO:0050829,GO:0050870,GO:0051091,GO:0051092,GO:0051260,GO:0051607,GO:0070374,GO:0070700,GO:0071222,GO:0071347,GO:0071356,GO:0071901,GO:0072332,GO:0072558,GO:0072559,GO:0090200,GO:0097153,GO:0097169,GO:0097202,GO:1900016,GO:2000406,GO:2001056,GO:2001238,GO:2001242" Golgi membrane|myeloid dendritic cell activation|protease binding|activation of innate immune response|positive regulation of defense response to virus by host|myeloid dendritic cell activation involved in immune response|positive regulation of antigen processing and presentation of peptide antigen via MHC class II|positive regulation of adaptive immune response|interleukin-6 receptor binding|protein binding|tropomyosin binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|signal transduction|IkappaB kinase complex|cysteine-type endopeptidase activator activity involved in apoptotic process|regulation of autophagy|regulation of tumor necrosis factor-mediated signaling pathway|myosin I binding|enzyme binding|positive regulation of actin filament polymerization|regulation of protein stability|negative regulation of NF-kappaB transcription factor activity|Pyrin domain binding|negative regulation of interferon-beta production|positive regulation of chemokine production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|protein-containing complex|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|azurophil granule lumen|positive regulation of activated T cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|protein homodimerization activity|neuronal cell body|positive regulation of apoptotic process|regulation of GTPase activity|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|ion channel binding|macropinocytosis|innate immune response|positive regulation of JNK cascade|protein dimerization activity|regulation of inflammatory response|positive regulation of phagocytosis|defense response to Gram-negative bacterium|positive regulation of T cell activation|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein homooligomerization|defense response to virus|positive regulation of ERK1 and ERK2 cascade|BMP receptor binding|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|negative regulation of protein serine/threonine kinase activity|intrinsic apoptotic signaling pathway by p53 class mediator|NLRP1 inflammasome complex|NLRP3 inflammasome complex|positive regulation of release of cytochrome c from mitochondria|cysteine-type endopeptidase activity involved in apoptotic process|AIM2 inflammasome complex|activation of cysteine-type endopeptidase activity|negative regulation of cytokine production involved in inflammatory response|positive regulation of T cell migration|positive regulation of cysteine-type endopeptidase activity|positive regulation of extrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway "hsa04217,hsa04621,hsa04623,hsa04625,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05164" Necroptosis|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Influenza A PYCR1 1174.925595 1313.353023 1036.498166 0.78919997 -0.341537194 0.319764956 1 30.78051707 25.33838326 5831 pyrroline-5-carboxylate reductase 1 "GO:0004735,GO:0005515,GO:0005739,GO:0005759,GO:0006561,GO:0008652,GO:0034599,GO:0042802,GO:0051881,GO:0055114,GO:0055129,GO:1903206" pyrroline-5-carboxylate reductase activity|protein binding|mitochondrion|mitochondrial matrix|proline biosynthetic process|cellular amino acid biosynthetic process|cellular response to oxidative stress|identical protein binding|regulation of mitochondrial membrane potential|oxidation-reduction process|L-proline biosynthetic process|negative regulation of hydrogen peroxide-induced cell death hsa00330 Arginine and proline metabolism PYCR2 1330.264084 1189.528395 1470.999774 1.236624346 0.306407314 0.363260679 1 35.86036714 46.25604043 29920 pyrroline-5-carboxylate reductase 2 "GO:0004735,GO:0005515,GO:0005739,GO:0005759,GO:0006561,GO:0008652,GO:0034599,GO:0055114,GO:0055129" pyrroline-5-carboxylate reductase activity|protein binding|mitochondrion|mitochondrial matrix|proline biosynthetic process|cellular amino acid biosynthetic process|cellular response to oxidative stress|oxidation-reduction process|L-proline biosynthetic process hsa00330 Arginine and proline metabolism PYCR3 670.1492956 853.5779694 486.7206218 0.570212259 -0.81042904 0.034127141 0.828970386 12.93558136 7.693756395 65263 pyrroline-5-carboxylate reductase 3 "GO:0004735,GO:0005515,GO:0005829,GO:0008652,GO:0045171,GO:0055114,GO:0055129,GO:0072686" pyrroline-5-carboxylate reductase activity|protein binding|cytosol|cellular amino acid biosynthetic process|intercellular bridge|oxidation-reduction process|L-proline biosynthetic process|mitotic spindle hsa00330 Arginine and proline metabolism PYGB 6172.611322 6192.246363 6152.976281 0.993658185 -0.00917844 0.978007288 1 76.19422579 78.97233961 5834 glycogen phosphorylase B "GO:0005515,GO:0005576,GO:0005737,GO:0005980,GO:0008184,GO:0016020,GO:0030170,GO:0035578,GO:0043312,GO:0070062,GO:0102250,GO:0102499" protein binding|extracellular region|cytoplasm|glycogen catabolic process|glycogen phosphorylase activity|membrane|pyridoxal phosphate binding|azurophil granule lumen|neutrophil degranulation|extracellular exosome|linear malto-oligosaccharide phosphorylase activity|SHG alpha-glucan phosphorylase activity "hsa00500,hsa04217,hsa04910,hsa04922,hsa04931" Starch and sucrose metabolism|Necroptosis|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance PYGL 3736.694987 3979.642352 3493.747621 0.877904925 -0.187863387 0.555298673 1 72.00959121 65.94073151 5836 glycogen phosphorylase L "GO:0002060,GO:0005515,GO:0005524,GO:0005536,GO:0005576,GO:0005737,GO:0005829,GO:0005977,GO:0005980,GO:0006015,GO:0008144,GO:0008184,GO:0009617,GO:0016208,GO:0019842,GO:0030170,GO:0032052,GO:0034774,GO:0042593,GO:0042802,GO:0043312,GO:0070062,GO:0070266,GO:0102250,GO:0102499,GO:1904813" purine nucleobase binding|protein binding|ATP binding|glucose binding|extracellular region|cytoplasm|cytosol|glycogen metabolic process|glycogen catabolic process|5-phosphoribose 1-diphosphate biosynthetic process|drug binding|glycogen phosphorylase activity|response to bacterium|AMP binding|vitamin binding|pyridoxal phosphate binding|bile acid binding|secretory granule lumen|glucose homeostasis|identical protein binding|neutrophil degranulation|extracellular exosome|necroptotic process|linear malto-oligosaccharide phosphorylase activity|SHG alpha-glucan phosphorylase activity|ficolin-1-rich granule lumen "hsa00500,hsa04217,hsa04910,hsa04922,hsa04931" Starch and sucrose metabolism|Necroptosis|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance PYGO1 346.8749332 341.0252054 352.7246611 1.034306719 0.048664073 0.920761427 1 1.912916556 2.063770031 26108 pygopus family PHD finger 1 "GO:0001822,GO:0002244,GO:0005515,GO:0005654,GO:0007289,GO:0034504,GO:0035064,GO:0045944,GO:0046872,GO:0060070,GO:1904837" kidney development|hematopoietic progenitor cell differentiation|protein binding|nucleoplasm|spermatid nucleus differentiation|protein localization to nucleus|methylated histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly PYGO2 1346.079533 1294.06886 1398.090207 1.080383162 0.111543061 0.741558941 1 20.61006998 23.22593484 90780 pygopus family PHD finger 2 "GO:0001822,GO:0002088,GO:0003682,GO:0005515,GO:0005654,GO:0007289,GO:0007420,GO:0030879,GO:0033599,GO:0035034,GO:0035065,GO:0035563,GO:0042393,GO:0046872,GO:0048589,GO:0051569,GO:0060021,GO:0060070,GO:1904837,GO:1990907" kidney development|lens development in camera-type eye|chromatin binding|protein binding|nucleoplasm|spermatid nucleus differentiation|brain development|mammary gland development|regulation of mammary gland epithelial cell proliferation|histone acetyltransferase regulator activity|regulation of histone acetylation|positive regulation of chromatin binding|histone binding|metal ion binding|developmental growth|regulation of histone H3-K4 methylation|roof of mouth development|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex PYM1 445.0962946 421.2067269 468.9858623 1.113433932 0.155015956 0.716176437 1 16.97106984 19.71013518 84305 "PYM homolog 1, exon junction complex associated factor" "GO:0000184,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0030054,GO:0035145,GO:0043022,GO:0045727,GO:1903259" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|cell junction|exon-exon junction complex|ribosome binding|positive regulation of translation|exon-exon junction complex disassembly" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway PYROXD1 175.063821 180.6621624 169.4654796 0.938024196 -0.092302958 0.879288767 1 2.360655621 2.309737399 79912 pyridine nucleotide-disulphide oxidoreductase domain 1 "GO:0005515,GO:0005634,GO:0016491,GO:0030017,GO:0034599,GO:0055114" protein binding|nucleus|oxidoreductase activity|sarcomere|cellular response to oxidative stress|oxidation-reduction process PYROXD2 300.6471778 279.1128913 322.1814642 1.154305209 0.207024736 0.665211873 1 1.543746128 1.858713556 84795 pyridine nucleotide-disulphide oxidoreductase domain 2 "GO:0005515,GO:0005759,GO:0007005,GO:0016491,GO:0055114" protein binding|mitochondrial matrix|mitochondrion organization|oxidoreductase activity|oxidation-reduction process PYY 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.248568372 0.151014498 5697 peptide YY "GO:0001664,GO:0005179,GO:0005184,GO:0005515,GO:0005576,GO:0005615,GO:0007186,GO:0007218,GO:0007631,GO:0031841,GO:0060575" G protein-coupled receptor binding|hormone activity|neuropeptide hormone activity|protein binding|extracellular region|extracellular space|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|feeding behavior|neuropeptide Y receptor binding|intestinal epithelial cell differentiation hsa04080 Neuroactive ligand-receptor interaction QARS1 6053.250322 5576.16809 6530.332553 1.171114724 0.227882411 0.482645566 1 115.3177796 140.8677709 5859 glutaminyl-tRNA synthetase 1 "GO:0004819,GO:0004860,GO:0005515,GO:0005524,GO:0005737,GO:0005759,GO:0005829,GO:0006418,GO:0006425,GO:0006469,GO:0007420,GO:0017101,GO:0019901,GO:0032873,GO:0032991,GO:0045892,GO:2001234" "glutamine-tRNA ligase activity|protein kinase inhibitor activity|protein binding|ATP binding|cytoplasm|mitochondrial matrix|cytosol|tRNA aminoacylation for protein translation|glutaminyl-tRNA aminoacylation|negative regulation of protein kinase activity|brain development|aminoacyl-tRNA synthetase multienzyme complex|protein kinase binding|negative regulation of stress-activated MAPK cascade|protein-containing complex|negative regulation of transcription, DNA-templated|negative regulation of apoptotic signaling pathway" hsa00970 Aminoacyl-tRNA biosynthesis QDPR 400.1925347 416.131947 384.2531225 0.923392509 -0.114984067 0.79537585 1 13.98514605 13.47005232 5860 quinoid dihydropteridine reductase "GO:0001889,GO:0004155,GO:0005737,GO:0005829,GO:0006520,GO:0006559,GO:0006729,GO:0009055,GO:0010044,GO:0010288,GO:0022900,GO:0033762,GO:0035690,GO:0042802,GO:0043005,GO:0051066,GO:0070062,GO:0070402,GO:0070404" "liver development|6,7-dihydropteridine reductase activity|cytoplasm|cytosol|cellular amino acid metabolic process|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process|electron transfer activity|response to aluminum ion|response to lead ion|electron transport chain|response to glucagon|cellular response to drug|identical protein binding|neuron projection|dihydrobiopterin metabolic process|extracellular exosome|NADPH binding|NADH binding" hsa00790 Folate biosynthesis QKI 1617.299669 1615.809902 1618.789436 1.001843988 0.002657863 0.995698079 1 6.176697961 6.454645443 9444 "QKI, KH domain containing RNA binding" "GO:0001570,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0006397,GO:0006417,GO:0007286,GO:0008380,GO:0010628,GO:0017124,GO:0042552,GO:0042692,GO:0042759,GO:0045202,GO:0048024,GO:0051028" "vasculogenesis|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|mRNA processing|regulation of translation|spermatid development|RNA splicing|positive regulation of gene expression|SH3 domain binding|myelination|muscle cell differentiation|long-chain fatty acid biosynthetic process|synapse|regulation of mRNA splicing, via spliceosome|mRNA transport" QPCT 10.94182901 7.104691779 14.77896625 2.080169937 1.056701392 0.455708066 1 0.213801292 0.463900746 25797 glutaminyl-peptide cyclotransferase "GO:0005515,GO:0005576,GO:0006464,GO:0008270,GO:0016603,GO:0017186,GO:0018215,GO:0035580,GO:0043312,GO:0070062,GO:1904724,GO:1904813" "protein binding|extracellular region|cellular protein modification process|zinc ion binding|glutaminyl-peptide cyclotransferase activity|peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|protein phosphopantetheinylation|specific granule lumen|neutrophil degranulation|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen" QPCTL 373.4122462 403.9524754 342.872017 0.848792959 -0.236515406 0.595442761 1 8.475048807 7.503431222 54814 glutaminyl-peptide cyclotransferase like "GO:0000139,GO:0005794,GO:0008270,GO:0016020,GO:0016021,GO:0016603,GO:0017186,GO:0018215" "Golgi membrane|Golgi apparatus|zinc ion binding|membrane|integral component of membrane|glutaminyl-peptide cyclotransferase activity|peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|protein phosphopantetheinylation" QPRT 1497.199847 1824.890831 1169.508862 0.64086511 -0.641907367 0.053390171 1 43.47332209 29.0606542 23475 quinolinate phosphoribosyltransferase "GO:0004514,GO:0005515,GO:0005737,GO:0005829,GO:0009435,GO:0019674,GO:0034213,GO:0042802,GO:0070062,GO:1902494" nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein binding|cytoplasm|cytosol|NAD biosynthetic process|NAD metabolic process|quinolinate catabolic process|identical protein binding|extracellular exosome|catalytic complex hsa00760 Nicotinate and nicotinamide metabolism QRICH1 2478.566013 2400.370865 2556.761161 1.065152555 0.091060074 0.776221914 1 30.8006882 34.22064285 54870 glutamine rich 1 "GO:0003674,GO:0005515,GO:0005654,GO:0008150" molecular_function|protein binding|nucleoplasm|biological_process QRICH2 20.95777671 18.26920743 23.646346 1.294327961 0.372203218 0.766546876 1 0.099171587 0.13388981 84074 glutamine rich 2 "GO:0005515,GO:0005737,GO:0030031,GO:0030317,GO:0031965,GO:0036126,GO:2000059" protein binding|cytoplasm|cell projection assembly|flagellated sperm motility|nuclear membrane|sperm flagellum|negative regulation of ubiquitin-dependent protein catabolic process QRSL1 288.8240048 279.1128913 298.5351182 1.06958556 0.097051894 0.845665194 1 3.468977495 3.870195854 55278 glutaminyl-tRNA amidotransferase subunit QRSL1 "GO:0005515,GO:0005524,GO:0005739,GO:0016787,GO:0030956,GO:0031647,GO:0032543,GO:0050567,GO:0070681" protein binding|ATP binding|mitochondrion|hydrolase activity|glutamyl-tRNA(Gln) amidotransferase complex|regulation of protein stability|mitochondrial translation|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|glutaminyl-tRNAGln biosynthesis via transamidation hsa00970 Aminoacyl-tRNA biosynthesis QSER1 2315.310273 2589.152675 2041.467871 0.788469483 -0.342873177 0.283692822 1 11.79557876 9.701079716 79832 glutamine and serine rich 1 QSOX1 3167.842849 3382.848243 2952.837456 0.872884991 -0.196136515 0.537670978 1 67.26711014 61.24571737 5768 quiescin sulfhydryl oxidase 1 "GO:0000139,GO:0002576,GO:0003756,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0006457,GO:0016242,GO:0016971,GO:0018215,GO:0030173,GO:0031093,GO:0035580,GO:0043231,GO:0043312,GO:0043687,GO:0044267,GO:0045171,GO:0055114,GO:0070062,GO:0071949,GO:0085029,GO:1904724" Golgi membrane|platelet degranulation|protein disulfide isomerase activity|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|protein folding|negative regulation of macroautophagy|flavin-linked sulfhydryl oxidase activity|protein phosphopantetheinylation|integral component of Golgi membrane|platelet alpha granule lumen|specific granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|intercellular bridge|oxidation-reduction process|extracellular exosome|FAD binding|extracellular matrix assembly|tertiary granule lumen QSOX2 1466.643288 1621.899637 1311.386938 0.808549992 -0.306591118 0.356602476 1 18.25005441 15.39171348 169714 quiescin sulfhydryl oxidase 2 "GO:0003756,GO:0005615,GO:0005654,GO:0005794,GO:0005886,GO:0006457,GO:0016971,GO:0018215,GO:0030173,GO:0031965,GO:0055114" protein disulfide isomerase activity|extracellular space|nucleoplasm|Golgi apparatus|plasma membrane|protein folding|flavin-linked sulfhydryl oxidase activity|protein phosphopantetheinylation|integral component of Golgi membrane|nuclear membrane|oxidation-reduction process QTRT1 405.3442651 397.8627396 412.8257905 1.037608576 0.053262308 0.907539428 1 15.16203475 16.40993912 81890 queuine tRNA-ribosyltransferase catalytic subunit 1 "GO:0005634,GO:0005741,GO:0006400,GO:0008479,GO:0032991,GO:0042803,GO:0046872,GO:0046982,GO:0101030" nucleus|mitochondrial outer membrane|tRNA modification|queuine tRNA-ribosyltransferase activity|protein-containing complex|protein homodimerization activity|metal ion binding|protein heterodimerization activity|tRNA-guanine transglycosylation QTRT2 712.9543578 782.5310516 643.377664 0.822175251 -0.28248215 0.453459208 1 9.920509928 8.507742278 79691 queuine tRNA-ribosyltransferase accessory subunit 2 "GO:0005737,GO:0005739,GO:0005741,GO:0006400,GO:0008479,GO:0032991,GO:0042803,GO:0046872,GO:0046982,GO:0101030" cytoplasm|mitochondrion|mitochondrial outer membrane|tRNA modification|queuine tRNA-ribosyltransferase activity|protein-containing complex|protein homodimerization activity|metal ion binding|protein heterodimerization activity|tRNA-guanine transglycosylation R3HCC1 412.6419519 425.2665507 400.0173531 0.94062736 -0.088304798 0.842143631 1 14.88476195 14.60412126 203069 R3H domain and coiled-coil containing 1 "GO:0003676,GO:0035145" nucleic acid binding|exon-exon junction complex R3HCC1L 1001.716258 1091.077666 912.3548497 0.836196064 -0.258086842 0.464326524 1 9.956618863 8.684322269 27291 R3H domain and coiled-coil containing 1 like "GO:0005515,GO:0035145" protein binding|exon-exon junction complex R3HDM1 826.3555213 890.1163843 762.5946584 0.856735896 -0.223077558 0.542134828 1 8.162457853 7.294303768 23518 R3H domain containing 1 GO:0003723 RNA binding R3HDM2 1628.958301 1436.162695 1821.753906 1.268487137 0.34310889 0.296161363 1 13.30709368 17.60699382 22864 R3H domain containing 2 "GO:0003723,GO:0005515,GO:0005634" RNA binding|protein binding|nucleus R3HDM4 879.3695263 843.4284097 915.310643 1.085226241 0.117995838 0.745668156 1 21.2944534 24.10475453 91300 R3H domain containing 4 "GO:0003676,GO:0005634" nucleic acid binding|nucleus RAB10 2352.831477 2325.264124 2380.39883 1.023711159 0.033808715 0.917042282 1 33.02479664 35.26415802 10890 "RAB10, member RAS oncogene family" "GO:0000139,GO:0000145,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0005929,GO:0006893,GO:0006904,GO:0007409,GO:0008021,GO:0009306,GO:0016192,GO:0016197,GO:0017157,GO:0019003,GO:0019882,GO:0030659,GO:0030667,GO:0030670,GO:0030859,GO:0031489,GO:0032593,GO:0032869,GO:0043001,GO:0043312,GO:0045055,GO:0045200,GO:0048471,GO:0055037,GO:0055038,GO:0070062,GO:0070382,GO:0071782,GO:0071786,GO:0072659,GO:0090150,GO:0097051,GO:0098609,GO:0098641,GO:1903361" Golgi membrane|exocyst|GTPase activity|protein binding|GTP binding|endosome|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|cilium|Golgi to plasma membrane transport|vesicle docking involved in exocytosis|axonogenesis|synaptic vesicle|protein secretion|vesicle-mediated transport|endosomal transport|regulation of exocytosis|GDP binding|antigen processing and presentation|cytoplasmic vesicle membrane|secretory granule membrane|phagocytic vesicle membrane|polarized epithelial cell differentiation|myosin V binding|insulin-responsive compartment|cellular response to insulin stimulus|Golgi to plasma membrane protein transport|neutrophil degranulation|regulated exocytosis|establishment of neuroblast polarity|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|extracellular exosome|exocytic vesicle|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization|protein localization to plasma membrane|establishment of protein localization to membrane|establishment of protein localization to endoplasmic reticulum membrane|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|protein localization to basolateral plasma membrane "hsa04144,hsa04152" Endocytosis|AMPK signaling pathway RAB11A 2572.008272 2322.219256 2821.797289 1.215129571 0.281110159 0.3781134 1 24.38569625 30.90819757 8766 "RAB11A, member RAS oncogene family" "GO:0000922,GO:0003091,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005771,GO:0005794,GO:0005802,GO:0005813,GO:0005828,GO:0005829,GO:0006887,GO:0007080,GO:0008017,GO:0010634,GO:0010796,GO:0010971,GO:0016192,GO:0019905,GO:0030133,GO:0030424,GO:0030659,GO:0030953,GO:0031175,GO:0031410,GO:0031489,GO:0031982,GO:0032154,GO:0032402,GO:0032465,GO:0032991,GO:0034394,GO:0034451,GO:0036258,GO:0043231,GO:0043687,GO:0045335,GO:0045773,GO:0048169,GO:0048227,GO:0048471,GO:0051223,GO:0051650,GO:0055037,GO:0055038,GO:0060627,GO:0070062,GO:0072594,GO:0072659,GO:0090150,GO:0090307,GO:0097711,GO:0098685,GO:0098837,GO:0098887,GO:0098978,GO:0099003,GO:0150093,GO:1903078,GO:1990182" "spindle pole|renal water homeostasis|GTPase activity|protein binding|GTP binding|endosome|multivesicular body|Golgi apparatus|trans-Golgi network|centrosome|kinetochore microtubule|cytosol|exocytosis|mitotic metaphase plate congression|microtubule binding|positive regulation of epithelial cell migration|regulation of multivesicular body size|positive regulation of G2/M transition of mitotic cell cycle|vesicle-mediated transport|syntaxin binding|transport vesicle|axon|cytoplasmic vesicle membrane|astral microtubule organization|neuron projection development|cytoplasmic vesicle|myosin V binding|vesicle|cleavage furrow|melanosome transport|regulation of cytokinesis|protein-containing complex|protein localization to cell surface|centriolar satellite|multivesicular body assembly|intracellular membrane-bounded organelle|post-translational protein modification|phagocytic vesicle|positive regulation of axon extension|regulation of long-term neuronal synaptic plasticity|plasma membrane to endosome transport|perinuclear region of cytoplasm|regulation of protein transport|establishment of vesicle localization|recycling endosome|recycling endosome membrane|regulation of vesicle-mediated transport|extracellular exosome|establishment of protein localization to organelle|protein localization to plasma membrane|establishment of protein localization to membrane|mitotic spindle assembly|ciliary basal body-plasma membrane docking|Schaffer collateral - CA1 synapse|postsynaptic recycling endosome|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|vesicle-mediated transport in synapse|amyloid-beta clearance by transcytosis|positive regulation of protein localization to plasma membrane|exosomal secretion" "hsa04144,hsa04961,hsa04962,hsa04972,hsa05164" Endocytosis|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Pancreatic secretion|Influenza A RAB11B 1700.473602 1509.239525 1891.70768 1.253417796 0.325867382 0.318882439 1 48.07399853 62.8524241 9230 "RAB11B, member RAS oncogene family" "GO:0001881,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005829,GO:0006887,GO:0008021,GO:0019003,GO:0030670,GO:0031489,GO:0032402,GO:0033572,GO:0035773,GO:0043687,GO:0044070,GO:0045054,GO:0045055,GO:0045296,GO:0045335,GO:0055037,GO:0055038,GO:0070062,GO:0071468,GO:0090150,GO:0098993,GO:0150093,GO:1990126,GO:2000008,GO:2001135" "receptor recycling|GTPase activity|protein binding|GTP binding|endosome|cytosol|exocytosis|synaptic vesicle|GDP binding|phagocytic vesicle membrane|myosin V binding|melanosome transport|transferrin transport|insulin secretion involved in cellular response to glucose stimulus|post-translational protein modification|regulation of anion transport|constitutive secretory pathway|regulated exocytosis|cadherin binding|phagocytic vesicle|recycling endosome|recycling endosome membrane|extracellular exosome|cellular response to acidic pH|establishment of protein localization to membrane|anchored component of synaptic vesicle membrane|amyloid-beta clearance by transcytosis|retrograde transport, endosome to plasma membrane|regulation of protein localization to cell surface|regulation of endocytic recycling" "hsa04144,hsa04152,hsa04962,hsa05164" Endocytosis|AMPK signaling pathway|Vasopressin-regulated water reabsorption|Influenza A RAB11FIP1 622.1509334 535.8967513 708.4051155 1.321905971 0.40261956 0.29934312 1 3.314358276 4.569997339 80223 RAB11 family interacting protein 1 "GO:0005829,GO:0015031,GO:0030670,GO:0043231,GO:0045055,GO:0055037,GO:0070164" cytosol|protein transport|phagocytic vesicle membrane|intracellular membrane-bounded organelle|regulated exocytosis|recycling endosome|negative regulation of adiponectin secretion hsa04144 Endocytosis RAB11FIP2 296.0420195 368.4290165 223.6550226 0.60705051 -0.720111532 0.129846347 1 2.88001697 1.823626125 22841 RAB11 family interacting protein 2 "GO:0001891,GO:0003091,GO:0005515,GO:0005654,GO:0005768,GO:0006909,GO:0019901,GO:0030010,GO:0030659,GO:0035669,GO:0035773,GO:0042802,GO:0042803,GO:0042995,GO:0043231,GO:0043547,GO:0045055,GO:0055038,GO:1903078" phagocytic cup|renal water homeostasis|protein binding|nucleoplasm|endosome|phagocytosis|protein kinase binding|establishment of cell polarity|cytoplasmic vesicle membrane|TRAM-dependent toll-like receptor 4 signaling pathway|insulin secretion involved in cellular response to glucose stimulus|identical protein binding|protein homodimerization activity|cell projection|intracellular membrane-bounded organelle|positive regulation of GTPase activity|regulated exocytosis|recycling endosome membrane|positive regulation of protein localization to plasma membrane hsa04144 Endocytosis RAB11FIP3 939.9929795 845.4583217 1034.527637 1.223629375 0.291166646 0.414202968 1 7.041519716 8.987361765 9727 RAB11 family interacting protein 3 "GO:0005509,GO:0005515,GO:0005654,GO:0005739,GO:0005768,GO:0005813,GO:0005829,GO:0007049,GO:0016192,GO:0030139,GO:0030496,GO:0031267,GO:0032154,GO:0032456,GO:0032465,GO:0034451,GO:0042803,GO:0043231,GO:0045171,GO:0051301,GO:0051959,GO:0055037,GO:0055038,GO:0061512,GO:0070164" calcium ion binding|protein binding|nucleoplasm|mitochondrion|endosome|centrosome|cytosol|cell cycle|vesicle-mediated transport|endocytic vesicle|midbody|small GTPase binding|cleavage furrow|endocytic recycling|regulation of cytokinesis|centriolar satellite|protein homodimerization activity|intracellular membrane-bounded organelle|intercellular bridge|cell division|dynein light intermediate chain binding|recycling endosome|recycling endosome membrane|protein localization to cilium|negative regulation of adiponectin secretion hsa04144 Endocytosis RAB11FIP4 21.85396647 12.17947162 31.52846133 2.588655921 1.372203218 0.2111913 1 0.070609807 0.190658109 84440 RAB11 family interacting protein 4 "GO:0003407,GO:0005509,GO:0005515,GO:0005615,GO:0005768,GO:0005813,GO:0005819,GO:0016032,GO:0030139,GO:0030496,GO:0031267,GO:0032154,GO:0032456,GO:0032465,GO:0042803,GO:0048471,GO:0055038,GO:1903452" neural retina development|calcium ion binding|protein binding|extracellular space|endosome|centrosome|spindle|viral process|endocytic vesicle|midbody|small GTPase binding|cleavage furrow|endocytic recycling|regulation of cytokinesis|protein homodimerization activity|perinuclear region of cytoplasm|recycling endosome membrane|positive regulation of G1 to G0 transition hsa04144 Endocytosis RAB11FIP5 1190.619802 1072.808459 1308.431145 1.219631645 0.286445489 0.403225409 1 8.645022082 10.99792417 26056 RAB11 family interacting protein 5 "GO:0000139,GO:0005515,GO:0005739,GO:0005741,GO:0005769,GO:0005794,GO:0030141,GO:0030658,GO:0031901,GO:0034451,GO:0035773,GO:0043015,GO:0043231,GO:0045055,GO:0045335,GO:0055037,GO:0055038,GO:0070164,GO:0071468,GO:2000008" Golgi membrane|protein binding|mitochondrion|mitochondrial outer membrane|early endosome|Golgi apparatus|secretory granule|transport vesicle membrane|early endosome membrane|centriolar satellite|insulin secretion involved in cellular response to glucose stimulus|gamma-tubulin binding|intracellular membrane-bounded organelle|regulated exocytosis|phagocytic vesicle|recycling endosome|recycling endosome membrane|negative regulation of adiponectin secretion|cellular response to acidic pH|regulation of protein localization to cell surface hsa04144 Endocytosis RAB12 780.5219208 754.1122845 806.9315572 1.070041655 0.09766696 0.794027963 1 12.86396998 14.3579234 201475 "RAB12, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005765,GO:0005768,GO:0005776,GO:0005794,GO:0005829,GO:0005886,GO:0006904,GO:0006914,GO:0008021,GO:0008333,GO:0009306,GO:0017157,GO:0019003,GO:0032482,GO:0032593,GO:0032869,GO:0044257,GO:0055037,GO:0055038,GO:0072659" Golgi membrane|GTPase activity|protein binding|GTP binding|lysosome|lysosomal membrane|endosome|autophagosome|Golgi apparatus|cytosol|plasma membrane|vesicle docking involved in exocytosis|autophagy|synaptic vesicle|endosome to lysosome transport|protein secretion|regulation of exocytosis|GDP binding|Rab protein signal transduction|insulin-responsive compartment|cellular response to insulin stimulus|cellular protein catabolic process|recycling endosome|recycling endosome membrane|protein localization to plasma membrane RAB13 2856.92883 2873.340346 2840.517313 0.988576698 -0.016575194 0.959638355 1 91.40989448 94.25827919 5872 "RAB13, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005923,GO:0006904,GO:0008021,GO:0009306,GO:0010737,GO:0016197,GO:0016328,GO:0017157,GO:0030027,GO:0030054,GO:0030139,GO:0030140,GO:0030659,GO:0030866,GO:0031175,GO:0031410,GO:0032456,GO:0032593,GO:0032869,GO:0035767,GO:0043005,GO:0043687,GO:0044795,GO:0048210,GO:0055037,GO:0055038,GO:0070062,GO:0070830,GO:0072659,GO:0097368" GTPase activity|protein binding|GTP binding|endosome|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|bicellular tight junction|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|protein kinase A signaling|endosomal transport|lateral plasma membrane|regulation of exocytosis|lamellipodium|cell junction|endocytic vesicle|trans-Golgi network transport vesicle|cytoplasmic vesicle membrane|cortical actin cytoskeleton organization|neuron projection development|cytoplasmic vesicle|endocytic recycling|insulin-responsive compartment|cellular response to insulin stimulus|endothelial cell chemotaxis|neuron projection|post-translational protein modification|trans-Golgi network to recycling endosome transport|Golgi vesicle fusion to target membrane|recycling endosome|recycling endosome membrane|extracellular exosome|bicellular tight junction assembly|protein localization to plasma membrane|establishment of Sertoli cell barrier hsa04530 Tight junction RAB14 2705.947325 2655.124813 2756.769837 1.038282579 0.05419914 0.865891407 1 32.41087131 35.10121934 51552 "RAB14, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005791,GO:0005795,GO:0005802,GO:0005829,GO:0005886,GO:0005929,GO:0006661,GO:0006886,GO:0006895,GO:0008543,GO:0012505,GO:0016192,GO:0019003,GO:0030140,GO:0031489,GO:0031901,GO:0032456,GO:0032880,GO:0042175,GO:0042742,GO:0043231,GO:0043312,GO:0045335,GO:0045995,GO:0046907,GO:0048471,GO:0055037,GO:0055038,GO:0070062,GO:0070821,GO:0090387" Golgi membrane|GTPase activity|protein binding|GTP binding|lysosome|lysosomal membrane|early endosome|late endosome|rough endoplasmic reticulum|Golgi stack|trans-Golgi network|cytosol|plasma membrane|cilium|phosphatidylinositol biosynthetic process|intracellular protein transport|Golgi to endosome transport|fibroblast growth factor receptor signaling pathway|endomembrane system|vesicle-mediated transport|GDP binding|trans-Golgi network transport vesicle|myosin V binding|early endosome membrane|endocytic recycling|regulation of protein localization|nuclear outer membrane-endoplasmic reticulum membrane network|defense response to bacterium|intracellular membrane-bounded organelle|neutrophil degranulation|phagocytic vesicle|regulation of embryonic development|intracellular transport|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|extracellular exosome|tertiary granule membrane|phagolysosome assembly involved in apoptotic cell clearance hsa04152 AMPK signaling pathway RAB15 863.8321878 623.1829646 1104.481411 1.772322855 0.825641436 0.023070628 0.666736237 8.7550676 16.18520749 376267 "RAB15, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005768,GO:0005794,GO:0005886,GO:0005929,GO:0006904,GO:0008021,GO:0009306,GO:0010008,GO:0017157,GO:0032482,GO:0032593,GO:0032869,GO:0048471,GO:0055037,GO:0070062,GO:0072659,GO:1903307" GTPase activity|protein binding|GTP binding|cytoplasm|endosome|Golgi apparatus|plasma membrane|cilium|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|endosome membrane|regulation of exocytosis|Rab protein signal transduction|insulin-responsive compartment|cellular response to insulin stimulus|perinuclear region of cytoplasm|recycling endosome|extracellular exosome|protein localization to plasma membrane|positive regulation of regulated secretory pathway RAB17 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.06234559 0.031564381 64284 "RAB17, member RAS oncogene family" "GO:0002415,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005769,GO:0005886,GO:0006886,GO:0006897,GO:0012505,GO:0016323,GO:0016324,GO:0019003,GO:0030100,GO:0030139,GO:0030425,GO:0032401,GO:0032402,GO:0032456,GO:0042470,GO:0043025,GO:0045056,GO:0046847,GO:0050773,GO:0051489,GO:0051963,GO:0055037,GO:0055038,GO:0060271,GO:0070062" immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor|GTPase activity|protein binding|GTP binding|endosome|early endosome|plasma membrane|intracellular protein transport|endocytosis|endomembrane system|basolateral plasma membrane|apical plasma membrane|GDP binding|regulation of endocytosis|endocytic vesicle|dendrite|establishment of melanosome localization|melanosome transport|endocytic recycling|melanosome|neuronal cell body|transcytosis|filopodium assembly|regulation of dendrite development|regulation of filopodium assembly|regulation of synapse assembly|recycling endosome|recycling endosome membrane|cilium assembly|extracellular exosome RAB18 1542.27928 1505.179701 1579.37886 1.04929588 0.069421546 0.835196049 1 15.39419263 16.84887135 22931 "RAB18, member RAS oncogene family" "GO:0001654,GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005794,GO:0005811,GO:0005829,GO:0005886,GO:0006886,GO:0007264,GO:0007420,GO:0012505,GO:0016032,GO:0016324,GO:0019003,GO:0030667,GO:0034389,GO:0043312,GO:0071782,GO:0071786" eye development|GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|cytosol|plasma membrane|intracellular protein transport|small GTPase mediated signal transduction|brain development|endomembrane system|viral process|apical plasma membrane|GDP binding|secretory granule membrane|lipid droplet organization|neutrophil degranulation|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization RAB19 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.022775339 0.115307186 401409 "RAB19, member RAS oncogene family" "GO:0000045,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0006886,GO:0012505,GO:0070062" autophagosome assembly|GTPase activity|protein binding|GTP binding|plasma membrane|intracellular protein transport|endomembrane system|extracellular exosome RAB1A 2458.80926 2666.289329 2251.329192 0.844367926 -0.244056316 0.444658592 1 55.16264232 48.58393855 5861 "RAB1A, member RAS oncogene family" "GO:0000045,GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005769,GO:0005783,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006897,GO:0006914,GO:0007030,GO:0012505,GO:0016192,GO:0016477,GO:0019068,GO:0030252,GO:0030658,GO:0032402,GO:0032637,GO:0034446,GO:0042470,GO:0042742,GO:0043687,GO:0045296,GO:0047496,GO:0048208,GO:0060271,GO:0070062,GO:0090110,GO:0090557,GO:1903020,GO:1904668" "autophagosome assembly|Golgi membrane|GTPase activity|protein binding|GTP binding|early endosome|endoplasmic reticulum|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|endocytosis|autophagy|Golgi organization|endomembrane system|vesicle-mediated transport|cell migration|virion assembly|growth hormone secretion|transport vesicle membrane|melanosome transport|interleukin-8 production|substrate adhesion-dependent cell spreading|melanosome|defense response to bacterium|post-translational protein modification|cadherin binding|vesicle transport along microtubule|COPII vesicle coating|cilium assembly|extracellular exosome|COPII-coated vesicle cargo loading|establishment of endothelial intestinal barrier|positive regulation of glycoprotein metabolic process|positive regulation of ubiquitin protein ligase activity" "hsa04140,hsa05014,hsa05022,hsa05130,hsa05134" Autophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Legionellosis RAB1B 7415.899471 7430.492644 7401.306297 0.996072084 -0.005677943 0.986678597 1 186.8561267 194.13956 81876 "RAB1B, member RAS oncogene family" "GO:0000045,GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0012505,GO:0019068,GO:0030133,GO:0033116,GO:0034045,GO:0043687,GO:0048208,GO:0048471,GO:0070062,GO:0090557,GO:1903020,GO:2000785" "autophagosome assembly|Golgi membrane|GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|endomembrane system|virion assembly|transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|phagophore assembly site membrane|post-translational protein modification|COPII vesicle coating|perinuclear region of cytoplasm|extracellular exosome|establishment of endothelial intestinal barrier|positive regulation of glycoprotein metabolic process|regulation of autophagosome assembly" hsa05134 Legionellosis RAB20 230.5691948 337.9803375 123.1580521 0.364394133 -1.456428364 0.005329953 0.281098008 11.3586674 4.317324461 55647 "RAB20, member RAS oncogene family" "GO:0003924,GO:0005525,GO:0005794,GO:0006886,GO:0012505,GO:0030670,GO:0043231,GO:0045335,GO:0071346,GO:0090383,GO:0090385" GTPase activity|GTP binding|Golgi apparatus|intracellular protein transport|endomembrane system|phagocytic vesicle membrane|intracellular membrane-bounded organelle|phagocytic vesicle|cellular response to interferon-gamma|phagosome acidification|phagosome-lysosome fusion RAB21 1132.887316 1133.705817 1132.068815 0.998556061 -0.002084669 0.99811604 1 3.690590059 3.844007173 23011 "RAB21, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005769,GO:0005789,GO:0005802,GO:0005829,GO:0005925,GO:0006886,GO:0008089,GO:0009898,GO:0012505,GO:0012506,GO:0017157,GO:0019003,GO:0030516,GO:0030659,GO:0031901,GO:0032154,GO:0032482,GO:0032580,GO:0045202,GO:0048260,GO:0050775,GO:0050821,GO:0070062,GO:0098559,GO:1904115,GO:2000643" GTPase activity|protein binding|GTP binding|endosome|early endosome|endoplasmic reticulum membrane|trans-Golgi network|cytosol|focal adhesion|intracellular protein transport|anterograde axonal transport|cytoplasmic side of plasma membrane|endomembrane system|vesicle membrane|regulation of exocytosis|GDP binding|regulation of axon extension|cytoplasmic vesicle membrane|early endosome membrane|cleavage furrow|Rab protein signal transduction|Golgi cisterna membrane|synapse|positive regulation of receptor-mediated endocytosis|positive regulation of dendrite morphogenesis|protein stabilization|extracellular exosome|cytoplasmic side of early endosome membrane|axon cytoplasm|positive regulation of early endosome to late endosome transport RAB22A 2183.648313 1974.089358 2393.207268 1.212309492 0.277758054 0.386365297 1 11.55712193 14.61433743 57403 "RAB22A, member RAS oncogene family" "GO:0001726,GO:0003924,GO:0005515,GO:0005525,GO:0005769,GO:0005770,GO:0005886,GO:0006886,GO:0006897,GO:0007032,GO:0010008,GO:0012505,GO:0015629,GO:0019003,GO:0030670,GO:0045335,GO:0070062,GO:0097494" ruffle|GTPase activity|protein binding|GTP binding|early endosome|late endosome|plasma membrane|intracellular protein transport|endocytosis|endosome organization|endosome membrane|endomembrane system|actin cytoskeleton|GDP binding|phagocytic vesicle membrane|phagocytic vesicle|extracellular exosome|regulation of vesicle size hsa04144 Endocytosis RAB23 378.5936681 387.7131799 369.4741562 0.952957432 -0.069516324 0.880258273 1 3.947789464 3.924130255 51715 "RAB23, member RAS oncogene family" "GO:0000045,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005776,GO:0005813,GO:0005829,GO:0005886,GO:0006886,GO:0006968,GO:0010008,GO:0012505,GO:0030054,GO:0030670,GO:0042308,GO:0045335,GO:0046039,GO:0060271,GO:0097094" autophagosome assembly|GTPase activity|protein binding|GTP binding|cytoplasm|autophagosome|centrosome|cytosol|plasma membrane|intracellular protein transport|cellular defense response|endosome membrane|endomembrane system|cell junction|phagocytic vesicle membrane|negative regulation of protein import into nucleus|phagocytic vesicle|GTP metabolic process|cilium assembly|craniofacial suture morphogenesis RAB24 569.1666199 584.6146378 553.7186021 0.94715145 -0.078332962 0.847008315 1 18.64525756 18.42059887 53917 "RAB24, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005776,GO:0005829,GO:0005886,GO:0006886,GO:0006914,GO:0012505,GO:0030139,GO:0030667,GO:0043312" GTPase activity|protein binding|GTP binding|endosome|autophagosome|cytosol|plasma membrane|intracellular protein transport|autophagy|endomembrane system|endocytic vesicle|secretory granule membrane|neutrophil degranulation RAB26 85.30628188 106.5703767 64.04218708 0.600937982 -0.734711986 0.305224962 1 1.729940263 1.084367994 25837 "RAB26, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005794,GO:0017157,GO:0019002,GO:0030667,GO:0031226,GO:0035272,GO:0043001,GO:0045055,GO:0098993,GO:0099575" "Golgi membrane|GTPase activity|protein binding|GTP binding|endosome|Golgi apparatus|regulation of exocytosis|GMP binding|secretory granule membrane|intrinsic component of plasma membrane|exocrine system development|Golgi to plasma membrane protein transport|regulated exocytosis|anchored component of synaptic vesicle membrane|regulation of protein catabolic process at presynapse, modulating synaptic transmission" RAB27A 372.645709 284.1876711 461.1037469 1.622532551 0.698247421 0.115178666 1 3.6782783 6.225208948 5873 "RAB27A, member RAS oncogene family" "GO:0001750,GO:0003924,GO:0005515,GO:0005525,GO:0005576,GO:0005764,GO:0005770,GO:0005794,GO:0005829,GO:0006605,GO:0006887,GO:0007596,GO:0010628,GO:0016324,GO:0019003,GO:0019882,GO:0019904,GO:0030141,GO:0030318,GO:0030425,GO:0030667,GO:0031489,GO:0032400,GO:0032402,GO:0032585,GO:0033093,GO:0033162,GO:0035580,GO:0036257,GO:0042470,GO:0043312,GO:0043316,GO:0043320,GO:0045921,GO:0048489,GO:0050766,GO:0070062,GO:0070382,GO:0071985,GO:0097278,GO:1903307,GO:1903428,GO:1903435,GO:1990182" photoreceptor outer segment|GTPase activity|protein binding|GTP binding|extracellular region|lysosome|late endosome|Golgi apparatus|cytosol|protein targeting|exocytosis|blood coagulation|positive regulation of gene expression|apical plasma membrane|GDP binding|antigen processing and presentation|protein domain specific binding|secretory granule|melanocyte differentiation|dendrite|secretory granule membrane|myosin V binding|melanosome localization|melanosome transport|multivesicular body membrane|Weibel-Palade body|melanosome membrane|specific granule lumen|multivesicular body organization|melanosome|neutrophil degranulation|cytotoxic T cell degranulation|natural killer cell degranulation|positive regulation of exocytosis|synaptic vesicle transport|positive regulation of phagocytosis|extracellular exosome|exocytic vesicle|multivesicular body sorting pathway|complement-dependent cytotoxicity|positive regulation of regulated secretory pathway|positive regulation of reactive oxygen species biosynthetic process|positive regulation of constitutive secretory pathway|exosomal secretion RAB27B 232.022843 268.9633316 195.0823545 0.725312084 -0.463326211 0.368031837 1 1.340752352 1.014353682 5874 "RAB27B, member RAS oncogene family" "GO:0002576,GO:0003924,GO:0005515,GO:0005525,GO:0005770,GO:0005795,GO:0005886,GO:0016324,GO:0019003,GO:0019904,GO:0030140,GO:0030141,GO:0031088,GO:0031489,GO:0032402,GO:0032585,GO:0042470,GO:0042589,GO:0045921,GO:0048488,GO:0070062,GO:0071985,GO:0098993,GO:0099641,GO:1904115" platelet degranulation|GTPase activity|protein binding|GTP binding|late endosome|Golgi stack|plasma membrane|apical plasma membrane|GDP binding|protein domain specific binding|trans-Golgi network transport vesicle|secretory granule|platelet dense granule membrane|myosin V binding|melanosome transport|multivesicular body membrane|melanosome|zymogen granule membrane|positive regulation of exocytosis|synaptic vesicle endocytosis|extracellular exosome|multivesicular body sorting pathway|anchored component of synaptic vesicle membrane|anterograde axonal protein transport|axon cytoplasm hsa04972 Pancreatic secretion RAB28 242.4477915 207.0510175 277.8445655 1.341913547 0.424291729 0.403423181 1 5.643920133 7.899895137 9364 "RAB28, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005886,GO:0006886,GO:0012505,GO:0019003,GO:0035253,GO:0036064,GO:1901998" GTPase activity|protein binding|GTP binding|cytoplasm|plasma membrane|intracellular protein transport|endomembrane system|GDP binding|ciliary rootlet|ciliary basal body|toxin transport RAB29 1445.693676 1503.149789 1388.237563 0.923552378 -0.11473431 0.731777888 1 23.09045618 22.24385082 8934 "RAB29, member RAS oncogene family" "GO:0001921,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005769,GO:0005773,GO:0005794,GO:0005801,GO:0005802,GO:0005829,GO:0005856,GO:0005886,GO:0006886,GO:0006888,GO:0007005,GO:0007030,GO:0007416,GO:0009617,GO:0010977,GO:0012505,GO:0019003,GO:0019894,GO:0020003,GO:0030154,GO:0031267,GO:0032438,GO:0039694,GO:0042110,GO:0042147,GO:0042470,GO:0043231,GO:0048471,GO:0050862,GO:0055037,GO:0070062,GO:0070840,GO:0072657,GO:0090316,GO:0097708,GO:1901214,GO:1901998,GO:1903441,GO:1905279" "positive regulation of receptor recycling|GTPase activity|protein binding|GTP binding|cytoplasm|mitochondrion|early endosome|vacuole|Golgi apparatus|cis-Golgi network|trans-Golgi network|cytosol|cytoskeleton|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|mitochondrion organization|Golgi organization|synapse assembly|response to bacterium|negative regulation of neuron projection development|endomembrane system|GDP binding|kinesin binding|symbiont-containing vacuole|cell differentiation|small GTPase binding|melanosome organization|viral RNA genome replication|T cell activation|retrograde transport, endosome to Golgi|melanosome|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|positive regulation of T cell receptor signaling pathway|recycling endosome|extracellular exosome|dynein complex binding|protein localization to membrane|positive regulation of intracellular protein transport|intracellular vesicle|regulation of neuron death|toxin transport|protein localization to ciliary membrane|regulation of retrograde transport, endosome to Golgi" RAB2A 3202.026229 3227.559979 3176.492479 0.984177676 -0.023009303 0.94333251 1 42.88156527 44.02101673 5862 "RAB2A, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005765,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0007030,GO:0015031,GO:0019003,GO:0033116,GO:0042470,GO:0043687,GO:0070062" Golgi membrane|GTPase activity|protein binding|GTP binding|nucleus|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|protein transport|GDP binding|endoplasmic reticulum-Golgi intermediate compartment membrane|melanosome|post-translational protein modification|extracellular exosome hsa04152 AMPK signaling pathway RAB2B 512.4748219 514.582676 510.3669678 0.99180752 -0.011867931 0.982068296 1 8.558882496 8.85442555 84932 "RAB2B, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005794,GO:0005886,GO:0015031,GO:0016192,GO:0045921,GO:0070062,GO:0098793" Golgi membrane|GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|protein transport|vesicle-mediated transport|positive regulation of exocytosis|extracellular exosome|presynapse RAB30 122.3818663 182.6920743 62.07165824 0.33976109 -1.557407454 0.015665232 0.552928428 0.916745176 0.324891391 27314 "RAB30, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005795,GO:0005801,GO:0005802,GO:0007030,GO:0031985,GO:0032482,GO:0043231" Golgi membrane|GTPase activity|protein binding|GTP binding|Golgi stack|cis-Golgi network|trans-Golgi network|Golgi organization|Golgi cisterna|Rab protein signal transduction|intracellular membrane-bounded organelle RAB31 1243.568734 1459.506683 1027.630786 0.704094609 -0.506158799 0.137062805 1 17.84186933 13.1034997 11031 "RAB31, member RAS oncogene family" "GO:0001891,GO:0003924,GO:0005515,GO:0005525,GO:0005769,GO:0005829,GO:0005886,GO:0006886,GO:0012505,GO:0019003,GO:0030667,GO:0031623,GO:0031901,GO:0032588,GO:0032869,GO:0036186,GO:0043001,GO:0043312,GO:0045055,GO:0045335,GO:0060100,GO:0090382" "phagocytic cup|GTPase activity|protein binding|GTP binding|early endosome|cytosol|plasma membrane|intracellular protein transport|endomembrane system|GDP binding|secretory granule membrane|receptor internalization|early endosome membrane|trans-Golgi network membrane|cellular response to insulin stimulus|early phagosome membrane|Golgi to plasma membrane protein transport|neutrophil degranulation|regulated exocytosis|phagocytic vesicle|positive regulation of phagocytosis, engulfment|phagosome maturation" hsa04144 Endocytosis RAB32 481.2338735 466.8797455 495.5880015 1.061489616 0.086090258 0.839067076 1 22.20264043 24.58308061 10981 "RAB32, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0005769,GO:0005783,GO:0005802,GO:0005829,GO:0006886,GO:0007005,GO:0012505,GO:0016020,GO:0016192,GO:0019882,GO:0030670,GO:0030742,GO:0031905,GO:0032438,GO:0033162,GO:0035612,GO:0035646,GO:0035650,GO:0035651,GO:0036461,GO:0042470,GO:0044233,GO:0045335,GO:0072657,GO:0090382,GO:1903232" GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial outer membrane|early endosome|endoplasmic reticulum|trans-Golgi network|cytosol|intracellular protein transport|mitochondrion organization|endomembrane system|membrane|vesicle-mediated transport|antigen processing and presentation|phagocytic vesicle membrane|GTP-dependent protein binding|early endosome lumen|melanosome organization|melanosome membrane|AP-2 adaptor complex binding|endosome to melanosome transport|AP-1 adaptor complex binding|AP-3 adaptor complex binding|BLOC-2 complex binding|melanosome|mitochondria-associated endoplasmic reticulum membrane|phagocytic vesicle|protein localization to membrane|phagosome maturation|melanosome assembly RAB33A 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.044467075 0.135076982 9363 "RAB33A, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005794,GO:0005886,GO:0019882,GO:0032482" Golgi membrane|GTPase activity|protein binding|GTP binding|endosome|Golgi apparatus|plasma membrane|antigen processing and presentation|Rab protein signal transduction RAB33B 182.2036475 129.914364 234.4929311 1.804980789 0.851983482 0.126089046 1 1.395779428 2.627878651 83452 "RAB33B, member RAS oncogene family" "GO:0000139,GO:0001558,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005794,GO:0005796,GO:0006891,GO:0006914,GO:0015031,GO:0032482,GO:0034067,GO:0048705,GO:0050678,GO:1903358,GO:1903434,GO:2000156" "Golgi membrane|regulation of cell growth|GTPase activity|protein binding|GTP binding|endosome|Golgi apparatus|Golgi lumen|intra-Golgi vesicle-mediated transport|autophagy|protein transport|Rab protein signal transduction|protein localization to Golgi apparatus|skeletal system morphogenesis|regulation of epithelial cell proliferation|regulation of Golgi organization|negative regulation of constitutive secretory pathway|regulation of retrograde vesicle-mediated transport, Golgi to ER" hsa04140 Autophagy - animal RAB34 2468.691842 2297.860312 2639.523372 1.14868748 0.199986342 0.531201304 1 75.57046653 90.54613576 83871 "RAB34, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0005795,GO:0005929,GO:0006897,GO:0019882,GO:0030030,GO:0030670,GO:0030742,GO:0031267,GO:0031982,GO:0031985,GO:0032418,GO:0032587,GO:0043001,GO:0044351,GO:0045335,GO:0045880,GO:0048471,GO:0070062,GO:0072659,GO:0090382,GO:0090385" GTPase activity|protein binding|GTP binding|Golgi apparatus|Golgi stack|cilium|endocytosis|antigen processing and presentation|cell projection organization|phagocytic vesicle membrane|GTP-dependent protein binding|small GTPase binding|vesicle|Golgi cisterna|lysosome localization|ruffle membrane|Golgi to plasma membrane protein transport|macropinocytosis|phagocytic vesicle|positive regulation of smoothened signaling pathway|perinuclear region of cytoplasm|extracellular exosome|protein localization to plasma membrane|phagosome maturation|phagosome-lysosome fusion RAB35 1753.124382 1707.155939 1799.092825 1.05385383 0.075674778 0.817711486 1 30.23126777 33.23170837 11021 "RAB35, member RAS oncogene family" "GO:0000281,GO:0003924,GO:0005515,GO:0005525,GO:0005546,GO:0005829,GO:0005886,GO:0005905,GO:0008104,GO:0010008,GO:0015031,GO:0016197,GO:0019003,GO:0019882,GO:0030665,GO:0031175,GO:0031253,GO:0032456,GO:0032482,GO:0036010,GO:0042470,GO:0045171,GO:0045334,GO:0048227,GO:0055038,GO:0070062,GO:0098993,GO:1990090" "mitotic cytokinesis|GTPase activity|protein binding|GTP binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|clathrin-coated pit|protein localization|endosome membrane|protein transport|endosomal transport|GDP binding|antigen processing and presentation|clathrin-coated vesicle membrane|neuron projection development|cell projection membrane|endocytic recycling|Rab protein signal transduction|protein localization to endosome|melanosome|intercellular bridge|clathrin-coated endocytic vesicle|plasma membrane to endosome transport|recycling endosome membrane|extracellular exosome|anchored component of synaptic vesicle membrane|cellular response to nerve growth factor stimulus" hsa04144 Endocytosis RAB36 315.1440743 259.8287279 370.4594206 1.425783144 0.51175457 0.27222325 1 2.080867876 3.094666912 9609 "RAB36, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0015031" Golgi membrane|GTPase activity|protein binding|GTP binding|Golgi apparatus|protein transport RAB37 4.52276453 6.08973581 2.95579325 0.485372985 -1.042834281 0.660953233 1 0.082865028 0.04195298 326624 "RAB37, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005793,GO:0005794,GO:0005886,GO:0015031,GO:0035577,GO:0035579,GO:0043312" GTPase activity|protein binding|GTP binding|endosome|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|plasma membrane|protein transport|azurophil granule membrane|specific granule membrane|neutrophil degranulation RAB38 335.7967706 358.2794568 313.3140845 0.87449637 -0.193475699 0.675464271 1 4.355638635 3.973066025 23682 "RAB38, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005764,GO:0005769,GO:0005783,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0007005,GO:0007264,GO:0012505,GO:0015031,GO:0016020,GO:0016192,GO:0030670,GO:0030742,GO:0031905,GO:0032438,GO:0033162,GO:0035612,GO:0035646,GO:0035650,GO:0035651,GO:0036461,GO:0042470,GO:0043687,GO:0044233,GO:0045335,GO:0060155,GO:0072657,GO:0090383,GO:1903232,GO:2001247" GTPase activity|protein binding|GTP binding|mitochondrion|lysosome|early endosome|endoplasmic reticulum|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|mitochondrion organization|small GTPase mediated signal transduction|endomembrane system|protein transport|membrane|vesicle-mediated transport|phagocytic vesicle membrane|GTP-dependent protein binding|early endosome lumen|melanosome organization|melanosome membrane|AP-2 adaptor complex binding|endosome to melanosome transport|AP-1 adaptor complex binding|AP-3 adaptor complex binding|BLOC-2 complex binding|melanosome|post-translational protein modification|mitochondria-associated endoplasmic reticulum membrane|phagocytic vesicle|platelet dense granule organization|protein localization to membrane|phagosome acidification|melanosome assembly|positive regulation of phosphatidylcholine biosynthetic process RAB39B 247.525293 183.7070303 311.3435556 1.69478302 0.76110058 0.130833633 1 2.726080575 4.819130891 116442 "RAB39B, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0005886,GO:0006914,GO:0010506,GO:0015031,GO:0016192,GO:0030659,GO:0031489,GO:0031982,GO:0032482,GO:0043005,GO:0050808" Golgi membrane|GTPase activity|protein binding|GTP binding|Golgi apparatus|plasma membrane|autophagy|regulation of autophagy|protein transport|vesicle-mediated transport|cytoplasmic vesicle membrane|myosin V binding|vesicle|Rab protein signal transduction|neuron projection|synapse organization "hsa04140,hsa05014,hsa05022" Autophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases RAB3A 70.97813211 70.03196182 71.92430241 1.027021099 0.038465821 0.980330668 1 2.134098561 2.286176565 5864 "RAB3A, member RAS oncogene family" "GO:0001669,GO:0001671,GO:0001778,GO:0003016,GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005768,GO:0005829,GO:0005886,GO:0006887,GO:0006904,GO:0007005,GO:0007269,GO:0007274,GO:0007409,GO:0008021,GO:0008022,GO:0009306,GO:0009791,GO:0010807,GO:0014047,GO:0014059,GO:0016079,GO:0016188,GO:0017157,GO:0030324,GO:0030424,GO:0030667,GO:0030742,GO:0031489,GO:0031630,GO:0032418,GO:0032781,GO:0032991,GO:0036465,GO:0043195,GO:0043312,GO:0043687,GO:0045054,GO:0045055,GO:0045921,GO:0048172,GO:0048471,GO:0048489,GO:0048786,GO:0048790,GO:0050975,GO:0051021,GO:0051117,GO:0051602,GO:0060201,GO:0060203,GO:0060478,GO:0061202,GO:0061670,GO:0070083,GO:0072659,GO:0097091,GO:0098993,GO:1903307,GO:1903561,GO:1905684,GO:2000300" acrosomal vesicle|ATPase activator activity|plasma membrane repair|respiratory system process|GTPase activity|protein binding|GTP binding|lysosome|endosome|cytosol|plasma membrane|exocytosis|vesicle docking involved in exocytosis|mitochondrion organization|neurotransmitter secretion|neuromuscular synaptic transmission|axonogenesis|synaptic vesicle|protein C-terminus binding|protein secretion|post-embryonic development|regulation of synaptic vesicle priming|glutamate secretion|regulation of dopamine secretion|synaptic vesicle exocytosis|synaptic vesicle maturation|regulation of exocytosis|lung development|axon|secretory granule membrane|GTP-dependent protein binding|myosin V binding|regulation of synaptic vesicle fusion to presynaptic active zone membrane|lysosome localization|positive regulation of ATPase activity|protein-containing complex|synaptic vesicle recycling|terminal bouton|neutrophil degranulation|post-translational protein modification|constitutive secretory pathway|regulated exocytosis|positive regulation of exocytosis|regulation of short-term neuronal synaptic plasticity|perinuclear region of cytoplasm|synaptic vesicle transport|presynaptic active zone|maintenance of presynaptic active zone structure|sensory perception of touch|GDP-dissociation inhibitor binding|ATPase binding|response to electrical stimulus|clathrin-sculpted acetylcholine transport vesicle membrane|clathrin-sculpted glutamate transport vesicle membrane|acrosomal vesicle exocytosis|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|evoked neurotransmitter secretion|clathrin-sculpted monoamine transport vesicle membrane|protein localization to plasma membrane|synaptic vesicle clustering|anchored component of synaptic vesicle membrane|positive regulation of regulated secretory pathway|extracellular vesicle|regulation of plasma membrane repair|regulation of synaptic vesicle exocytosis "hsa04721,hsa04911" Synaptic vesicle cycle|Insulin secretion RAB3B 4014.467545 2661.214549 5367.720541 2.017019087 1.012224737 0.001646631 0.12602812 10.25575473 21.57712432 5865 "RAB3B, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0006904,GO:0008021,GO:0009306,GO:0017157,GO:0019003,GO:0019882,GO:0031489,GO:0031982,GO:0048471,GO:0051586,GO:0070062,GO:0072659,GO:0097494,GO:0098691,GO:0098693,GO:0098993" GTPase activity|protein binding|GTP binding|cytoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|regulation of exocytosis|GDP binding|antigen processing and presentation|myosin V binding|vesicle|perinuclear region of cytoplasm|positive regulation of dopamine uptake involved in synaptic transmission|extracellular exosome|protein localization to plasma membrane|regulation of vesicle size|dopaminergic synapse|regulation of synaptic vesicle cycle|anchored component of synaptic vesicle membrane RAB3C 11.41961545 6.08973581 16.74949508 2.750446916 1.459666059 0.286793197 1 0.033803555 0.096979864 115827 "RAB3C, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005829,GO:0005886,GO:0006904,GO:0008021,GO:0009306,GO:0017157,GO:0019882,GO:0030742,GO:0031489,GO:0031982,GO:0048471,GO:0072659,GO:0098993" GTPase activity|protein binding|GTP binding|endosome|cytosol|plasma membrane|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|regulation of exocytosis|antigen processing and presentation|GTP-dependent protein binding|myosin V binding|vesicle|perinuclear region of cytoplasm|protein localization to plasma membrane|anchored component of synaptic vesicle membrane RAB3D 1453.577275 1301.173551 1605.980999 1.234255797 0.303641421 0.361832383 1 15.54241748 20.00965845 9545 "RAB3D, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005881,GO:0005886,GO:0006904,GO:0008021,GO:0009306,GO:0017157,GO:0018125,GO:0030742,GO:0031489,GO:0035577,GO:0042588,GO:0043312,GO:0045453,GO:0070062,GO:0072659,GO:0099503,GO:1903307" GTPase activity|protein binding|GTP binding|endosome|cytoplasmic microtubule|plasma membrane|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|regulation of exocytosis|peptidyl-cysteine methylation|GTP-dependent protein binding|myosin V binding|azurophil granule membrane|zymogen granule|neutrophil degranulation|bone resorption|extracellular exosome|protein localization to plasma membrane|secretory vesicle|positive regulation of regulated secretory pathway hsa04972 Pancreatic secretion RAB3GAP1 1285.3482 1149.945112 1420.751289 1.235494872 0.305089022 0.367709562 1 11.22603376 14.46715788 22930 RAB3 GTPase activating protein catalytic subunit 1 "GO:0005085,GO:0005096,GO:0005515,GO:0005789,GO:0005794,GO:0005811,GO:0005829,GO:0007420,GO:0021854,GO:0031267,GO:0032991,GO:0034389,GO:0043010,GO:0043087,GO:0043547,GO:0048172,GO:0060079,GO:0060325,GO:0061646,GO:0070062,GO:0071782,GO:0097051,GO:0098794,GO:1903061,GO:1903233,GO:1903373,GO:2000786" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|cytosol|brain development|hypothalamus development|small GTPase binding|protein-containing complex|lipid droplet organization|camera-type eye development|regulation of GTPase activity|positive regulation of GTPase activity|regulation of short-term neuronal synaptic plasticity|excitatory postsynaptic potential|face morphogenesis|positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization|extracellular exosome|endoplasmic reticulum tubular network|establishment of protein localization to endoplasmic reticulum membrane|postsynapse|positive regulation of protein lipidation|regulation of calcium ion-dependent exocytosis of neurotransmitter|positive regulation of endoplasmic reticulum tubular network organization|positive regulation of autophagosome assembly RAB3GAP2 1776.734355 1603.63043 1949.83828 1.215890048 0.282012773 0.386338544 1 11.19325028 14.19601495 25782 RAB3 GTPase activating non-catalytic protein subunit 2 "GO:0005085,GO:0005096,GO:0005515,GO:0005789,GO:0005829,GO:0005886,GO:0006886,GO:0008047,GO:0030234,GO:0031267,GO:0032991,GO:0043087,GO:0043547,GO:0097051,GO:1903061,GO:1903373,GO:2000786" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|endoplasmic reticulum membrane|cytosol|plasma membrane|intracellular protein transport|enzyme activator activity|enzyme regulator activity|small GTPase binding|protein-containing complex|regulation of GTPase activity|positive regulation of GTPase activity|establishment of protein localization to endoplasmic reticulum membrane|positive regulation of protein lipidation|positive regulation of endoplasmic reticulum tubular network organization|positive regulation of autophagosome assembly RAB3IL1 326.0386443 297.3820987 354.69519 1.192725425 0.254261961 0.583839243 1 3.98237816 4.954489406 5866 RAB3A interacting protein like 1 "GO:0005085,GO:0005515,GO:0005829,GO:0006887,GO:0015031,GO:0042802,GO:0050790,GO:0070319" guanyl-nucleotide exchange factor activity|protein binding|cytosol|exocytosis|protein transport|identical protein binding|regulation of catalytic activity|Golgi to plasma membrane transport vesicle RAB3IP 579.8560708 574.4650781 585.2470634 1.018768739 0.026826597 0.950389569 1 2.714557717 2.88463335 117177 RAB3A interacting protein "GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0006612,GO:0006887,GO:0030027,GO:0050790,GO:0070319,GO:0097711" guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|cytoskeleton|protein targeting to membrane|exocytosis|lamellipodium|regulation of catalytic activity|Golgi to plasma membrane transport vesicle|ciliary basal body-plasma membrane docking RAB40AL 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.099910475 0.202331054 282808 RAB40A like "GO:0003924,GO:0005525,GO:0005737,GO:0005739,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0035556,GO:0072659" GTPase activity|GTP binding|cytoplasm|mitochondrion|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|intracellular signal transduction|protein localization to plasma membrane RAB40B 182.3224138 138.0340117 226.6108158 1.641702744 0.715192928 0.198601812 1 1.408894748 2.412620446 10966 "RAB40B, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005635,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0035556,GO:0048471,GO:0072659,GO:1901998" GTPase activity|protein binding|GTP binding|nuclear envelope|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|intracellular signal transduction|perinuclear region of cytoplasm|protein localization to plasma membrane|toxin transport RAB40C 406.3740668 400.9076075 411.8405261 1.027270419 0.038816008 0.934277359 1 7.1219067 7.631273037 57799 "RAB40C, member RAS oncogene family" "GO:0003924,GO:0005525,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0019003,GO:0035556,GO:0048471,GO:0072659" GTPase activity|GTP binding|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|GDP binding|intracellular signal transduction|perinuclear region of cytoplasm|protein localization to plasma membrane RAB42 113.6386959 123.8246281 103.4527637 0.835478089 -0.259326101 0.697967708 1 2.559706363 2.230699873 115273 "RAB42, member RAS oncogene family" "GO:0003924,GO:0005525,GO:0005886,GO:0007265,GO:0019003" GTPase activity|GTP binding|plasma membrane|Ras protein signal transduction|GDP binding RAB43 33.09271101 39.58328277 26.60213925 0.672054903 -0.573348998 0.562092828 1 0.428457711 0.300350699 339122 "RAB43, member RAS oncogene family" "GO:0000045,GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0006886,GO:0007030,GO:0012505,GO:0019068,GO:0030670,GO:0032588,GO:0035526,GO:0045335,GO:0070062,GO:0071346,GO:0090382,GO:1901998" "autophagosome assembly|GTPase activity|protein binding|GTP binding|Golgi apparatus|intracellular protein transport|Golgi organization|endomembrane system|virion assembly|phagocytic vesicle membrane|trans-Golgi network membrane|retrograde transport, plasma membrane to Golgi|phagocytic vesicle|extracellular exosome|cellular response to interferon-gamma|phagosome maturation|toxin transport" RAB4A 399.2666534 420.1917709 378.341536 0.90040206 -0.151358738 0.731034529 1 7.124616956 6.691352817 5867 "RAB4A, member RAS oncogene family" "GO:0001671,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005829,GO:0005886,GO:0006661,GO:0015031,GO:0019003,GO:0019882,GO:0019905,GO:0030100,GO:0030659,GO:0031901,GO:0031982,GO:0032482,GO:0032593,GO:0032781,GO:0035255,GO:0043231,GO:0048471,GO:0051117,GO:0055038,GO:0070062,GO:0098837,GO:0098993" ATPase activator activity|GTPase activity|protein binding|GTP binding|endosome|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|protein transport|GDP binding|antigen processing and presentation|syntaxin binding|regulation of endocytosis|cytoplasmic vesicle membrane|early endosome membrane|vesicle|Rab protein signal transduction|insulin-responsive compartment|positive regulation of ATPase activity|ionotropic glutamate receptor binding|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|ATPase binding|recycling endosome membrane|extracellular exosome|postsynaptic recycling endosome|anchored component of synaptic vesicle membrane hsa04144 Endocytosis RAB4B 136.5818473 143.1087915 130.054903 0.908783462 -0.137991514 0.831543832 1 6.253628502 5.928003114 53916 "RAB4B, member RAS oncogene family" "GO:0003674,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005886,GO:0015031,GO:0030100,GO:0030667,GO:0032482,GO:0032593,GO:0043312,GO:0046323,GO:0048471,GO:0055037" molecular_function|GTPase activity|protein binding|GTP binding|endosome|plasma membrane|protein transport|regulation of endocytosis|secretory granule membrane|Rab protein signal transduction|insulin-responsive compartment|neutrophil degranulation|glucose import|perinuclear region of cytoplasm|recycling endosome RAB5A 1455.782615 1350.906394 1560.658836 1.155267932 0.208227483 0.532064326 1 27.17182015 32.74291792 5868 "RAB5A, member RAS oncogene family" "GO:0001726,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006661,GO:0006886,GO:0006897,GO:0006909,GO:0007596,GO:0008021,GO:0010008,GO:0012505,GO:0015629,GO:0019003,GO:0030100,GO:0030139,GO:0030424,GO:0030425,GO:0030665,GO:0030670,GO:0031901,GO:0032009,GO:0036465,GO:0036477,GO:0039694,GO:0042470,GO:0043025,GO:0043195,GO:0043231,GO:0043679,GO:0043687,GO:0045022,GO:0045121,GO:0045335,GO:0045921,GO:0048169,GO:0051036,GO:0051489,GO:0061024,GO:0070062,GO:0098559,GO:0098842,GO:0098993,GO:0150093,GO:2000286,GO:2000300,GO:2000785" ruffle|GTPase activity|protein binding|GTP binding|nucleoplasm|cytoplasm|endosome|early endosome|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|intracellular protein transport|endocytosis|phagocytosis|blood coagulation|synaptic vesicle|endosome membrane|endomembrane system|actin cytoskeleton|GDP binding|regulation of endocytosis|endocytic vesicle|axon|dendrite|clathrin-coated vesicle membrane|phagocytic vesicle membrane|early endosome membrane|early phagosome|synaptic vesicle recycling|somatodendritic compartment|viral RNA genome replication|melanosome|neuronal cell body|terminal bouton|intracellular membrane-bounded organelle|axon terminus|post-translational protein modification|early endosome to late endosome transport|membrane raft|phagocytic vesicle|positive regulation of exocytosis|regulation of long-term neuronal synaptic plasticity|regulation of endosome size|regulation of filopodium assembly|membrane organization|extracellular exosome|cytoplasmic side of early endosome membrane|postsynaptic early endosome|anchored component of synaptic vesicle membrane|amyloid-beta clearance by transcytosis|receptor internalization involved in canonical Wnt signaling pathway|regulation of synaptic vesicle exocytosis|regulation of autophagosome assembly "hsa04014,hsa04144,hsa04145,hsa04962,hsa05014,hsa05022,hsa05132,hsa05146,hsa05152" Ras signaling pathway|Endocytosis|Phagosome|Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Amoebiasis|Tuberculosis RAB5B 1084.42057 885.0416044 1283.799535 1.450552752 0.536602763 0.122993728 1 12.26045816 18.55052292 5869 "RAB5B, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005769,GO:0005886,GO:0006886,GO:0006897,GO:0007032,GO:0012505,GO:0016020,GO:0019003,GO:0019882,GO:0030100,GO:0030139,GO:0030667,GO:0030742,GO:0031901,GO:0042470,GO:0043231,GO:0043312,GO:0048227,GO:0070062,GO:0098993" GTPase activity|protein binding|GTP binding|endosome|early endosome|plasma membrane|intracellular protein transport|endocytosis|endosome organization|endomembrane system|membrane|GDP binding|antigen processing and presentation|regulation of endocytosis|endocytic vesicle|secretory granule membrane|GTP-dependent protein binding|early endosome membrane|melanosome|intracellular membrane-bounded organelle|neutrophil degranulation|plasma membrane to endosome transport|extracellular exosome|anchored component of synaptic vesicle membrane "hsa04014,hsa04144,hsa04145,hsa04962,hsa05132,hsa05146,hsa05152" Ras signaling pathway|Endocytosis|Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection|Amoebiasis|Tuberculosis RAB5C 3963.204357 4309.503042 3616.905673 0.839286024 -0.252765538 0.427766072 1 110.6239868 96.84455928 5878 "RAB5C, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005765,GO:0005768,GO:0005769,GO:0005811,GO:0005886,GO:0006886,GO:0006897,GO:0012505,GO:0019003,GO:0030100,GO:0030139,GO:0031901,GO:0035577,GO:0042470,GO:0043312,GO:0048227,GO:0070062" GTPase activity|protein binding|GTP binding|lysosomal membrane|endosome|early endosome|lipid droplet|plasma membrane|intracellular protein transport|endocytosis|endomembrane system|GDP binding|regulation of endocytosis|endocytic vesicle|early endosome membrane|azurophil granule membrane|melanosome|neutrophil degranulation|plasma membrane to endosome transport|extracellular exosome "hsa04014,hsa04144,hsa04145,hsa04962,hsa05132,hsa05146,hsa05152" Ras signaling pathway|Endocytosis|Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection|Amoebiasis|Tuberculosis RAB5IF 629.5470975 637.3923481 621.7018468 0.975383292 -0.035958835 0.930122656 1 29.69795202 30.21466219 55969 RAB5 interacting factor "GO:0003674,GO:0005515,GO:0005746,GO:0016021,GO:0097250" molecular_function|protein binding|mitochondrial respirasome|integral component of membrane|mitochondrial respirasome assembly RAB6A 2866.284882 2738.351203 2994.218562 1.093438475 0.128872045 0.686074331 1 39.85282416 45.45371494 5870 "RAB6A, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006890,GO:0006891,GO:0012505,GO:0016020,GO:0016032,GO:0018125,GO:0019882,GO:0019904,GO:0030667,GO:0031410,GO:0031489,GO:0032588,GO:0034067,GO:0034498,GO:0042147,GO:0043312,GO:0070062,GO:0070381,GO:0072385" "Golgi membrane|GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|endomembrane system|membrane|viral process|peptidyl-cysteine methylation|antigen processing and presentation|protein domain specific binding|secretory granule membrane|cytoplasmic vesicle|myosin V binding|trans-Golgi network membrane|protein localization to Golgi apparatus|early endosome to Golgi transport|retrograde transport, endosome to Golgi|neutrophil degranulation|extracellular exosome|endosome to plasma membrane transport vesicle|minus-end-directed organelle transport along microtubule" RAB6B 72.12942167 47.70293051 96.55591282 2.024108619 1.017286711 0.179438961 1 0.424452766 0.896146705 51560 "RAB6B, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005793,GO:0005794,GO:0005829,GO:0006886,GO:0006890,GO:0006891,GO:0012505,GO:0031410,GO:0031489,GO:0042147,GO:0098793" "Golgi membrane|GTPase activity|protein binding|GTP binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|endomembrane system|cytoplasmic vesicle|myosin V binding|retrograde transport, endosome to Golgi|presynapse" RAB6C 13.55344781 17.25425146 9.852644165 0.571027041 -0.808369028 0.542896236 1 0.284369335 0.169377363 84084 "RAB6C, member RAS oncogene family" "GO:0000278,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005794,GO:0005813,GO:0005829,GO:0006886,GO:0006890,GO:0006891,GO:0007264,GO:0010824,GO:0012505,GO:0042147,GO:0042493" "mitotic cell cycle|GTPase activity|protein binding|GTP binding|nucleus|Golgi apparatus|centrosome|cytosol|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|small GTPase mediated signal transduction|regulation of centrosome duplication|endomembrane system|retrograde transport, endosome to Golgi|response to drug" RAB6D 17.56873436 22.3290313 12.80843742 0.573622619 -0.801826182 0.504377076 1 0.307556884 0.184021112 150786 "RAB6D, member RAS oncogene family" "GO:0003924,GO:0005525,GO:0005794,GO:0005829,GO:0006886,GO:0006890,GO:0006891,GO:0012505,GO:0042147" "GTPase activity|GTP binding|Golgi apparatus|cytosol|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|endomembrane system|retrograde transport, endosome to Golgi" RAB7A 4617.592636 4388.669607 4846.515665 1.104324567 0.143164251 0.654875864 1 101.7256903 117.1772521 7879 "RAB7A, member RAS oncogene family" "GO:0000045,GO:0000421,GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005765,GO:0005770,GO:0005811,GO:0005829,GO:0005886,GO:0006622,GO:0006897,GO:0007174,GO:0008333,GO:0010008,GO:0015031,GO:0016042,GO:0019003,GO:0019076,GO:0019886,GO:0022615,GO:0030667,GO:0030670,GO:0030904,GO:0031902,GO:0032419,GO:0033162,GO:0042147,GO:0043312,GO:0045022,GO:0045335,GO:0045732,GO:0048524,GO:0061724,GO:0070062,GO:0090382,GO:0090383,GO:0090385,GO:0099638,GO:1902586,GO:1903542,GO:1903543,GO:1905366,GO:1905394" "autophagosome assembly|autophagosome membrane|GTPase activity|protein binding|GTP binding|lysosome|lysosomal membrane|late endosome|lipid droplet|cytosol|plasma membrane|protein targeting to lysosome|endocytosis|epidermal growth factor catabolic process|endosome to lysosome transport|endosome membrane|protein transport|lipid catabolic process|GDP binding|viral release from host cell|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein to membrane docking|secretory granule membrane|phagocytic vesicle membrane|retromer complex|late endosome membrane|extrinsic component of lysosome membrane|melanosome membrane|retrograde transport, endosome to Golgi|neutrophil degranulation|early endosome to late endosome transport|phagocytic vesicle|positive regulation of protein catabolic process|positive regulation of viral process|lipophagy|extracellular exosome|phagosome maturation|phagosome acidification|phagosome-lysosome fusion|endosome to plasma membrane protein transport|multi-organism intercellular transport|negative regulation of exosomal secretion|positive regulation of exosomal secretion|negative regulation of intralumenal vesicle formation|retromer complex binding" "hsa04137,hsa04140,hsa04144,hsa04145,hsa05132,hsa05146,hsa05152" Mitophagy - animal|Autophagy - animal|Endocytosis|Phagosome|Salmonella infection|Amoebiasis|Tuberculosis RAB8A 1309.639596 1295.083816 1324.195376 1.022478514 0.032070528 0.926609661 1 25.55178281 27.25155747 4218 "RAB8A, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0006904,GO:0006914,GO:0007409,GO:0008021,GO:0009306,GO:0010506,GO:0014069,GO:0017157,GO:0019003,GO:0019901,GO:0030140,GO:0030496,GO:0030670,GO:0031267,GO:0031489,GO:0032588,GO:0032869,GO:0043025,GO:0043197,GO:0043687,GO:0045335,GO:0048169,GO:0048210,GO:0051223,GO:0055038,GO:0060271,GO:0070062,GO:0072659,GO:0097730,GO:0098887,GO:0098969,GO:0098978,GO:0099003" "Golgi membrane|GTPase activity|protein binding|GTP binding|endosome|centrosome|centriole|cytosol|plasma membrane|cilium|vesicle docking involved in exocytosis|autophagy|axonogenesis|synaptic vesicle|protein secretion|regulation of autophagy|postsynaptic density|regulation of exocytosis|GDP binding|protein kinase binding|trans-Golgi network transport vesicle|midbody|phagocytic vesicle membrane|small GTPase binding|myosin V binding|trans-Golgi network membrane|cellular response to insulin stimulus|neuronal cell body|dendritic spine|post-translational protein modification|phagocytic vesicle|regulation of long-term neuronal synaptic plasticity|Golgi vesicle fusion to target membrane|regulation of protein transport|recycling endosome membrane|cilium assembly|extracellular exosome|protein localization to plasma membrane|non-motile cilium|neurotransmitter receptor transport, endosome to postsynaptic membrane|neurotransmitter receptor transport to postsynaptic membrane|glutamatergic synapse|vesicle-mediated transport in synapse" "hsa04140,hsa04144,hsa04152,hsa04530,hsa04972,hsa05014,hsa05022" Autophagy - animal|Endocytosis|AMPK signaling pathway|Tight junction|Pancreatic secretion|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases RAB8B 557.5337204 631.3026123 483.7648285 0.766296256 -0.384025837 0.334721989 1 3.747450798 2.995356878 51762 "RAB8B, member RAS oncogene family" "GO:0003924,GO:0005102,GO:0005515,GO:0005525,GO:0005654,GO:0005768,GO:0005778,GO:0005886,GO:0006904,GO:0008021,GO:0009306,GO:0016604,GO:0017157,GO:0019003,GO:0019882,GO:0030140,GO:0030670,GO:0030911,GO:0031346,GO:0032869,GO:0043231,GO:0045046,GO:0045335,GO:0048210,GO:0048471,GO:0051286,GO:0051461,GO:0055038,GO:0060271,GO:0070062,GO:0072659,GO:0150115" GTPase activity|signaling receptor binding|protein binding|GTP binding|nucleoplasm|endosome|peroxisomal membrane|plasma membrane|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|nuclear body|regulation of exocytosis|GDP binding|antigen processing and presentation|trans-Golgi network transport vesicle|phagocytic vesicle membrane|TPR domain binding|positive regulation of cell projection organization|cellular response to insulin stimulus|intracellular membrane-bounded organelle|protein import into peroxisome membrane|phagocytic vesicle|Golgi vesicle fusion to target membrane|perinuclear region of cytoplasm|cell tip|positive regulation of corticotropin secretion|recycling endosome membrane|cilium assembly|extracellular exosome|protein localization to plasma membrane|cell-substrate junction organization hsa04530 Tight junction RAB9A 424.3639261 384.668312 464.0595402 1.206388792 0.27069493 0.527467589 1 9.578216802 12.05279823 9367 "RAB9A, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005770,GO:0005789,GO:0005829,GO:0005886,GO:0015031,GO:0019003,GO:0030133,GO:0030670,GO:0032482,GO:0032588,GO:0032880,GO:0042147,GO:0042470,GO:0045335,GO:0045921,GO:0052405,GO:0070062" "GTPase activity|protein binding|GTP binding|lysosome|late endosome|endoplasmic reticulum membrane|cytosol|plasma membrane|protein transport|GDP binding|transport vesicle|phagocytic vesicle membrane|Rab protein signal transduction|trans-Golgi network membrane|regulation of protein localization|retrograde transport, endosome to Golgi|melanosome|phagocytic vesicle|positive regulation of exocytosis|negative regulation by host of symbiont molecular function|extracellular exosome" "hsa05132,hsa05162" Salmonella infection|Measles RAB9B 19.04663098 22.3290313 15.76423066 0.705997069 -0.5022659 0.683916782 1 0.299810886 0.220783303 51209 "RAB9B, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005770,GO:0005829,GO:0005886,GO:0015031,GO:0019003,GO:0030667,GO:0030670,GO:0032482,GO:0042147,GO:0042802,GO:0043312,GO:0045335" "GTPase activity|protein binding|GTP binding|lysosome|late endosome|cytosol|plasma membrane|protein transport|GDP binding|secretory granule membrane|phagocytic vesicle membrane|Rab protein signal transduction|retrograde transport, endosome to Golgi|identical protein binding|neutrophil degranulation|phagocytic vesicle" "hsa05132,hsa05162" Salmonella infection|Measles RABAC1 1813.145839 1769.068253 1857.223425 1.049831414 0.070157673 0.83035634 1 119.4627548 130.8181548 10567 Rab acceptor 1 "GO:0005515,GO:0005794,GO:0005886,GO:0008021,GO:0008022,GO:0016020,GO:0016021,GO:0042802,GO:0070064" protein binding|Golgi apparatus|plasma membrane|synaptic vesicle|protein C-terminus binding|membrane|integral component of membrane|identical protein binding|proline-rich region binding RABEP1 1602.665201 1490.970318 1714.360085 1.149828447 0.201418629 0.540837388 1 16.45867192 19.73984631 9135 "rabaptin, RAB GTPase binding effector protein 1" "GO:0005096,GO:0005515,GO:0005768,GO:0005769,GO:0006893,GO:0006897,GO:0006915,GO:0007165,GO:0008083,GO:0015031,GO:0016192,GO:0019904,GO:0030139,GO:0031901,GO:0032991,GO:0042803,GO:0043231,GO:0043547,GO:0055037,GO:0061025,GO:1903441" GTPase activator activity|protein binding|endosome|early endosome|Golgi to plasma membrane transport|endocytosis|apoptotic process|signal transduction|growth factor activity|protein transport|vesicle-mediated transport|protein domain specific binding|endocytic vesicle|early endosome membrane|protein-containing complex|protein homodimerization activity|intracellular membrane-bounded organelle|positive regulation of GTPase activity|recycling endosome|membrane fusion|protein localization to ciliary membrane hsa04144 Endocytosis RABEP2 214.8900794 209.0809295 220.6992293 1.055568434 0.078020114 0.89070997 1 4.590035321 5.053803498 79874 "rabaptin, RAB GTPase binding effector protein 2" "GO:0005096,GO:0005515,GO:0005769,GO:0005813,GO:0005829,GO:0006897,GO:0007165,GO:0008083,GO:0015031,GO:0030030,GO:0036064,GO:0043231,GO:0043547,GO:1902017" GTPase activator activity|protein binding|early endosome|centrosome|cytosol|endocytosis|signal transduction|growth factor activity|protein transport|cell projection organization|ciliary basal body|intracellular membrane-bounded organelle|positive regulation of GTPase activity|regulation of cilium assembly RABEPK 313.4056346 343.0551173 283.756152 0.827144496 -0.273788716 0.559753384 1 8.073667038 6.965754251 10244 Rab9 effector protein with kelch motifs "GO:0005515,GO:0005768,GO:0005829,GO:0006898,GO:0006904,GO:0010008,GO:0030133,GO:0032588" protein binding|endosome|cytosol|receptor-mediated endocytosis|vesicle docking involved in exocytosis|endosome membrane|transport vesicle|trans-Golgi network membrane RABGAP1 1840.08275 1690.916643 1989.248857 1.176432242 0.234418229 0.470187329 1 13.61076967 16.70188669 23637 RAB GTPase activating protein 1 "GO:0005096,GO:0005515,GO:0005813,GO:0005829,GO:0005875,GO:0006886,GO:0007049,GO:0015631,GO:0031267,GO:0043087,GO:0090630,GO:1902017" GTPase activator activity|protein binding|centrosome|cytosol|microtubule associated complex|intracellular protein transport|cell cycle|tubulin binding|small GTPase binding|regulation of GTPase activity|activation of GTPase activity|regulation of cilium assembly RABGAP1L 584.7851144 540.9715311 628.5986978 1.161981105 0.21658661 0.583597438 1 2.116189049 2.564894218 9910 RAB GTPase activating protein 1 like "GO:0005096,GO:0005634,GO:0005769,GO:0005794,GO:0006886,GO:0006897,GO:0031267,GO:0032880,GO:0090630" GTPase activator activity|nucleus|early endosome|Golgi apparatus|intracellular protein transport|endocytosis|small GTPase binding|regulation of protein localization|activation of GTPase activity RABGEF1 933.4442624 970.2979058 896.5906191 0.924036436 -0.113978354 0.751357812 1 7.031358695 6.77710602 27342 RAB guanine nucleotide exchange factor 1 "GO:0003677,GO:0005085,GO:0005515,GO:0005730,GO:0005769,GO:0005829,GO:0006612,GO:0006897,GO:0008270,GO:0031267,GO:0031901,GO:0050790,GO:0055037" DNA binding|guanyl-nucleotide exchange factor activity|protein binding|nucleolus|early endosome|cytosol|protein targeting to membrane|endocytosis|zinc ion binding|small GTPase binding|early endosome membrane|regulation of catalytic activity|recycling endosome RABGGTA 468.2918241 457.7451417 478.8385064 1.046081024 0.064994599 0.880530492 1 11.91324594 12.99904243 5875 Rab geranylgeranyltransferase subunit alpha "GO:0004663,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005968,GO:0006464,GO:0007601,GO:0008270,GO:0018215,GO:0018344,GO:0031267,GO:0042981,GO:0043687" Rab geranylgeranyltransferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|Rab-protein geranylgeranyltransferase complex|cellular protein modification process|visual perception|zinc ion binding|protein phosphopantetheinylation|protein geranylgeranylation|small GTPase binding|regulation of apoptotic process|post-translational protein modification RABGGTB 1470.56554 1485.895538 1455.235543 0.979365983 -0.030080009 0.929960918 1 51.97193858 53.09209482 5876 Rab geranylgeranyltransferase subunit beta "GO:0004663,GO:0005515,GO:0005829,GO:0005886,GO:0005968,GO:0006464,GO:0007601,GO:0008270,GO:0018215,GO:0018342,GO:0018344,GO:0031267,GO:0042981,GO:0043687" Rab geranylgeranyltransferase activity|protein binding|cytosol|plasma membrane|Rab-protein geranylgeranyltransferase complex|cellular protein modification process|visual perception|zinc ion binding|protein phosphopantetheinylation|protein prenylation|protein geranylgeranylation|small GTPase binding|regulation of apoptotic process|post-translational protein modification RABIF 471.3191246 496.3134685 446.3247807 0.899280009 -0.153157696 0.715187635 1 8.059162005 7.559633748 5877 RAB interacting factor "GO:0005085,GO:0005515,GO:0005829,GO:0006892,GO:0007264,GO:0008270,GO:0015031,GO:0016020,GO:0050790,GO:0061025" guanyl-nucleotide exchange factor activity|protein binding|cytosol|post-Golgi vesicle-mediated transport|small GTPase mediated signal transduction|zinc ion binding|protein transport|membrane|regulation of catalytic activity|membrane fusion RABL2A 60.4695522 58.86744617 62.07165824 1.054430968 0.076464647 0.945631272 1 0.784380025 0.862701608 11159 "RAB, member of RAS oncogene family like 2A" "GO:0003924,GO:0005525,GO:0006886,GO:0012505" GTPase activity|GTP binding|intracellular protein transport|endomembrane system RABL2B 308.229656 292.3073189 324.151993 1.108942445 0.149184491 0.755296308 1 3.323829031 3.844710229 11158 "RAB, member of RAS oncogene family like 2B" "GO:0000242,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005814,GO:0006886,GO:0012505,GO:0036064,GO:0042073,GO:0060271" pericentriolar material|GTPase activity|protein binding|GTP binding|cytoplasm|centriole|intracellular protein transport|endomembrane system|ciliary basal body|intraciliary transport|cilium assembly RABL3 494.8048887 451.6554059 537.9543714 1.191072584 0.252261334 0.53972564 1 3.93645723 4.890572429 285282 "RAB, member of RAS oncogene family like 3" "GO:0001779,GO:0003924,GO:0005515,GO:0005525,GO:0006886,GO:0012505,GO:0030183,GO:0033077,GO:0042803,GO:0046578,GO:0050821,GO:1903059" natural killer cell differentiation|GTPase activity|protein binding|GTP binding|intracellular protein transport|endomembrane system|B cell differentiation|T cell differentiation in thymus|protein homodimerization activity|regulation of Ras protein signal transduction|protein stabilization|regulation of protein lipidation RABL6 2452.883074 2294.815444 2610.950704 1.137760647 0.186197086 0.560022248 1 30.52910603 36.23105039 55684 "RAB, member RAS oncogene family like 6" "GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005813,GO:0005829" protein binding|GTP binding|nucleus|cytoplasm|centrosome|cytosol RAC1 8196.421638 7814.146001 8578.697275 1.097841949 0.134670371 0.68438001 1 167.2692005 191.5454023 5879 Rac family small GTPase 1 "GO:0000139,GO:0001764,GO:0001934,GO:0002551,GO:0003376,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005789,GO:0005802,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005925,GO:0005938,GO:0006954,GO:0007015,GO:0007155,GO:0007160,GO:0007163,GO:0007596,GO:0008045,GO:0008283,GO:0008360,GO:0008361,GO:0009611,GO:0009653,GO:0010310,GO:0010591,GO:0010592,GO:0010595,GO:0010764,GO:0010811,GO:0016020,GO:0016601,GO:0019899,GO:0019901,GO:0030027,GO:0030031,GO:0030032,GO:0030036,GO:0030041,GO:0030334,GO:0030667,GO:0030865,GO:0031116,GO:0031234,GO:0031295,GO:0031410,GO:0031529,GO:0031996,GO:0032587,GO:0032707,GO:0032956,GO:0034446,GO:0035025,GO:0035556,GO:0035774,GO:0036464,GO:0038095,GO:0038096,GO:0042470,GO:0042826,GO:0042995,GO:0043197,GO:0043231,GO:0043312,GO:0043652,GO:0044877,GO:0045428,GO:0045453,GO:0045740,GO:0048010,GO:0048012,GO:0048013,GO:0048261,GO:0048870,GO:0050690,GO:0051022,GO:0051056,GO:0051117,GO:0051492,GO:0051496,GO:0051668,GO:0051894,GO:0051897,GO:0055038,GO:0060071,GO:0060263,GO:0070062,GO:0071260,GO:0071526,GO:0090023,GO:0097178,GO:0098794,GO:0098978,GO:0101003,GO:1900026,GO:1902622" "Golgi membrane|neuron migration|positive regulation of protein phosphorylation|mast cell chemotaxis|sphingosine-1-phosphate receptor signaling pathway|GTPase activity|protein binding|GTP binding|cytoplasm|endoplasmic reticulum membrane|trans-Golgi network|cytosol|cytoskeleton|actin filament|plasma membrane|focal adhesion|cell cortex|inflammatory response|actin filament organization|cell adhesion|cell-matrix adhesion|establishment or maintenance of cell polarity|blood coagulation|motor neuron axon guidance|cell population proliferation|regulation of cell shape|regulation of cell size|response to wounding|anatomical structure morphogenesis|regulation of hydrogen peroxide metabolic process|regulation of lamellipodium assembly|positive regulation of lamellipodium assembly|positive regulation of endothelial cell migration|negative regulation of fibroblast migration|positive regulation of cell-substrate adhesion|membrane|Rac protein signal transduction|enzyme binding|protein kinase binding|lamellipodium|cell projection assembly|lamellipodium assembly|actin cytoskeleton organization|actin filament polymerization|regulation of cell migration|secretory granule membrane|cortical cytoskeleton organization|positive regulation of microtubule polymerization|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|cytoplasmic vesicle|ruffle organization|thioesterase binding|ruffle membrane|negative regulation of interleukin-23 production|regulation of actin cytoskeleton organization|substrate adhesion-dependent cell spreading|positive regulation of Rho protein signal transduction|intracellular signal transduction|positive regulation of insulin secretion involved in cellular response to glucose stimulus|cytoplasmic ribonucleoprotein granule|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|melanosome|histone deacetylase binding|cell projection|dendritic spine|intracellular membrane-bounded organelle|neutrophil degranulation|engulfment of apoptotic cell|protein-containing complex binding|regulation of nitric oxide biosynthetic process|bone resorption|positive regulation of DNA replication|vascular endothelial growth factor receptor signaling pathway|hepatocyte growth factor receptor signaling pathway|ephrin receptor signaling pathway|negative regulation of receptor-mediated endocytosis|cell motility|regulation of defense response to virus by virus|Rho GDP-dissociation inhibitor binding|regulation of small GTPase mediated signal transduction|ATPase binding|regulation of stress fiber assembly|positive regulation of stress fiber assembly|localization within membrane|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|recycling endosome membrane|Wnt signaling pathway, planar cell polarity pathway|regulation of respiratory burst|extracellular exosome|cellular response to mechanical stimulus|semaphorin-plexin signaling pathway|positive regulation of neutrophil chemotaxis|ruffle assembly|postsynapse|glutamatergic synapse|ficolin-1-rich granule membrane|positive regulation of substrate adhesion-dependent cell spreading|regulation of neutrophil migration" "hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04071,hsa04145,hsa04151,hsa04310,hsa04360,hsa04370,hsa04380,hsa04510,hsa04520,hsa04530,hsa04620,hsa04650,hsa04662,hsa04664,hsa04666,hsa04670,hsa04722,hsa04810,hsa04932,hsa04933,hsa04972,hsa05014,hsa05020,hsa05022,hsa05100,hsa05120,hsa05130,hsa05131,hsa05132,hsa05135,hsa05163,hsa05167,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05210,hsa05211,hsa05212,hsa05231,hsa05416,hsa05418" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Phagosome|PI3K-Akt signaling pathway|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Adherens junction|Tight junction|Toll-like receptor signaling pathway|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Pancreatic secretion|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Choline metabolism in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis RAC2 3500.990145 3829.428869 3172.551421 0.828465949 -0.271485693 0.393565515 1 118.4048002 102.3198517 5880 Rac family small GTPase 2 "GO:0003924,GO:0005515,GO:0005525,GO:0005635,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005925,GO:0005938,GO:0007015,GO:0007163,GO:0007165,GO:0007186,GO:0008045,GO:0008284,GO:0008360,GO:0010310,GO:0010592,GO:0010810,GO:0016601,GO:0019887,GO:0019901,GO:0030027,GO:0030031,GO:0030670,GO:0030865,GO:0031410,GO:0032956,GO:0042129,GO:0042995,GO:0043231,GO:0043304,GO:0043652,GO:0045453,GO:0045454,GO:0045859,GO:0051056,GO:0051897,GO:0060263,GO:0060753,GO:0070062,GO:0071593,GO:0090023,GO:1902622,GO:1903955" GTPase activity|protein binding|GTP binding|nuclear envelope|cytosol|cytoskeleton|actin filament|plasma membrane|focal adhesion|cell cortex|actin filament organization|establishment or maintenance of cell polarity|signal transduction|G protein-coupled receptor signaling pathway|motor neuron axon guidance|positive regulation of cell population proliferation|regulation of cell shape|regulation of hydrogen peroxide metabolic process|positive regulation of lamellipodium assembly|regulation of cell-substrate adhesion|Rac protein signal transduction|protein kinase regulator activity|protein kinase binding|lamellipodium|cell projection assembly|phagocytic vesicle membrane|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|regulation of T cell proliferation|cell projection|intracellular membrane-bounded organelle|regulation of mast cell degranulation|engulfment of apoptotic cell|bone resorption|cell redox homeostasis|regulation of protein kinase activity|regulation of small GTPase mediated signal transduction|positive regulation of protein kinase B signaling|regulation of respiratory burst|regulation of mast cell chemotaxis|extracellular exosome|lymphocyte aggregation|positive regulation of neutrophil chemotaxis|regulation of neutrophil migration|positive regulation of protein targeting to mitochondrion "hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04071,hsa04310,hsa04360,hsa04370,hsa04510,hsa04520,hsa04650,hsa04662,hsa04664,hsa04666,hsa04670,hsa04810,hsa05020,hsa05135,hsa05163,hsa05170,hsa05200,hsa05210,hsa05212,hsa05231,hsa05416,hsa05418" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Prion disease|Yersinia infection|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis RAC3 346.9288731 412.0721232 281.7856231 0.683825979 -0.548298862 0.225495239 1 20.10597238 14.34123682 5881 Rac family small GTPase 3 "GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007264,GO:0008360,GO:0012505,GO:0014041,GO:0016055,GO:0019901,GO:0021894,GO:0030027,GO:0030031,GO:0030036,GO:0030426,GO:0030865,GO:0031175,GO:0031410,GO:0031941,GO:0032956,GO:0033630,GO:0035556,GO:0042995,GO:0043005,GO:0043025,GO:0043231,GO:0045202,GO:0048306,GO:0048471,GO:0048873,GO:0050885,GO:0051056,GO:0051932,GO:0070062,GO:0071944,GO:1900026" "GTPase activity|protein binding|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|endomembrane system|regulation of neuron maturation|Wnt signaling pathway|protein kinase binding|cerebral cortex GABAergic interneuron development|lamellipodium|cell projection assembly|actin cytoskeleton organization|growth cone|cortical cytoskeleton organization|neuron projection development|cytoplasmic vesicle|filamentous actin|regulation of actin cytoskeleton organization|positive regulation of cell adhesion mediated by integrin|intracellular signal transduction|cell projection|neuron projection|neuronal cell body|intracellular membrane-bounded organelle|synapse|calcium-dependent protein binding|perinuclear region of cytoplasm|homeostasis of number of cells within a tissue|neuromuscular process controlling balance|regulation of small GTPase mediated signal transduction|synaptic transmission, GABAergic|extracellular exosome|cell periphery|positive regulation of substrate adhesion-dependent cell spreading" "hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04071,hsa04310,hsa04360,hsa04370,hsa04510,hsa04520,hsa04650,hsa04662,hsa04664,hsa04810,hsa05135,hsa05163,hsa05170,hsa05200,hsa05210,hsa05212,hsa05231,hsa05416,hsa05418" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Regulation of actin cytoskeleton|Yersinia infection|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis other RACGAP1 3021.612486 2748.500762 3294.724209 1.198735054 0.261512827 0.411196627 1 35.26776475 44.09781491 29127 Rac GTPase activating protein 1 "GO:0000281,GO:0000915,GO:0001669,GO:0005096,GO:0005515,GO:0005547,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005874,GO:0006890,GO:0007018,GO:0007283,GO:0007405,GO:0008017,GO:0008272,GO:0019886,GO:0019901,GO:0030496,GO:0031234,GO:0032154,GO:0032467,GO:0035556,GO:0043014,GO:0043015,GO:0043547,GO:0045995,GO:0046872,GO:0048487,GO:0051056,GO:0051233,GO:0051256,GO:0051988,GO:0070062,GO:0072686,GO:0090543,GO:0097149" "mitotic cytokinesis|actomyosin contractile ring assembly|acrosomal vesicle|GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|spindle|cytosol|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|spermatogenesis|neuroblast proliferation|microtubule binding|sulfate transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|midbody|extrinsic component of cytoplasmic side of plasma membrane|cleavage furrow|positive regulation of cytokinesis|intracellular signal transduction|alpha-tubulin binding|gamma-tubulin binding|positive regulation of GTPase activity|regulation of embryonic development|metal ion binding|beta-tubulin binding|regulation of small GTPase mediated signal transduction|spindle midzone|mitotic spindle midzone assembly|regulation of attachment of spindle microtubules to kinetochore|extracellular exosome|mitotic spindle|Flemming body|centralspindlin complex" RACK1 36969.05223 36674.41896 37263.6855 1.016067508 0.022996259 0.954688588 1 1629.324509 1726.81608 10399 receptor for activated C kinase 1 "GO:0001891,GO:0001934,GO:0003723,GO:0005080,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0006919,GO:0007049,GO:0007369,GO:0008200,GO:0008656,GO:0010629,GO:0010803,GO:0015935,GO:0016032,GO:0016567,GO:0017148,GO:0019899,GO:0019903,GO:0030178,GO:0030292,GO:0030308,GO:0030332,GO:0030335,GO:0030425,GO:0030496,GO:0030971,GO:0031334,GO:0032091,GO:0032436,GO:0032880,GO:0033137,GO:0035591,GO:0042169,GO:0042803,GO:0042998,GO:0043022,GO:0043025,GO:0043065,GO:0043204,GO:0043547,GO:0045296,GO:0045879,GO:0048471,GO:0048511,GO:0050765,GO:0051302,GO:0051343,GO:0051434,GO:0051726,GO:0051898,GO:0051901,GO:0060090,GO:0061099,GO:0070062,GO:0071333,GO:0071363,GO:0072344,GO:1900102,GO:1903208,GO:1990630,GO:2000114,GO:2000304,GO:2000543,GO:2001244" phagocytic cup|positive regulation of protein phosphorylation|RNA binding|protein kinase C binding|signaling receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell cycle|gastrulation|ion channel inhibitor activity|cysteine-type endopeptidase activator activity involved in apoptotic process|negative regulation of gene expression|regulation of tumor necrosis factor-mediated signaling pathway|small ribosomal subunit|viral process|protein ubiquitination|negative regulation of translation|enzyme binding|protein phosphatase binding|negative regulation of Wnt signaling pathway|protein tyrosine kinase inhibitor activity|negative regulation of cell growth|cyclin binding|positive regulation of cell migration|dendrite|midbody|receptor tyrosine kinase binding|positive regulation of protein-containing complex assembly|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of protein localization|negative regulation of peptidyl-serine phosphorylation|signaling adaptor activity|SH2 domain binding|protein homodimerization activity|positive regulation of Golgi to plasma membrane protein transport|ribosome binding|neuronal cell body|positive regulation of apoptotic process|perikaryon|positive regulation of GTPase activity|cadherin binding|negative regulation of smoothened signaling pathway|perinuclear region of cytoplasm|rhythmic process|negative regulation of phagocytosis|regulation of cell division|positive regulation of cyclic-nucleotide phosphodiesterase activity|BH3 domain binding|regulation of cell cycle|negative regulation of protein kinase B signaling|positive regulation of mitochondrial depolarization|molecular adaptor activity|negative regulation of protein tyrosine kinase activity|extracellular exosome|cellular response to glucose stimulus|cellular response to growth factor stimulus|rescue of stalled ribosome|negative regulation of endoplasmic reticulum unfolded protein response|negative regulation of hydrogen peroxide-induced neuron death|IRE1-RACK1-PP2A complex|regulation of establishment of cell polarity|positive regulation of ceramide biosynthetic process|positive regulation of gastrulation|positive regulation of intrinsic apoptotic signaling pathway hsa05162 Measles RAD1 843.896048 708.4392659 979.35283 1.382409018 0.467184534 0.19893304 1 7.952116488 11.46661474 5810 RAD1 checkpoint DNA exonuclease "GO:0000077,GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006260,GO:0006281,GO:0006974,GO:0008408,GO:0008853,GO:0021762,GO:0030896,GO:0043231,GO:0051598,GO:0071479,GO:0090305,GO:1901796" DNA damage checkpoint|damaged DNA binding|protein binding|nucleus|nucleoplasm|chromosome|DNA replication|DNA repair|cellular response to DNA damage stimulus|3'-5' exonuclease activity|exodeoxyribonuclease III activity|substantia nigra development|checkpoint clamp complex|intracellular membrane-bounded organelle|meiotic recombination checkpoint|cellular response to ionizing radiation|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence RAD17 813.1625776 661.7512914 964.5738638 1.45760783 0.543602614 0.13796598 1 8.86415456 13.47702216 5884 RAD17 checkpoint clamp loader component "GO:0000076,GO:0000077,GO:0000781,GO:0003682,GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006260,GO:0006281,GO:0006974,GO:0008156,GO:0031389,GO:0031573,GO:0033314,GO:0042325,GO:1901796" "DNA replication checkpoint|DNA damage checkpoint|chromosome, telomeric region|chromatin binding|DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|DNA replication|DNA repair|cellular response to DNA damage stimulus|negative regulation of DNA replication|Rad17 RFC-like complex|intra-S DNA damage checkpoint|mitotic DNA replication checkpoint|regulation of phosphorylation|regulation of signal transduction by p53 class mediator" RAD18 940.6461937 890.1163843 991.176003 1.113535287 0.155147276 0.66471164 1 7.462548373 8.667763895 56852 RAD18 E3 ubiquitin protein ligase "GO:0000403,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005813,GO:0006281,GO:0006301,GO:0006513,GO:0006974,GO:0009411,GO:0016567,GO:0016604,GO:0031593,GO:0031625,GO:0035861,GO:0042405,GO:0042769,GO:0042802,GO:0044877,GO:0046872,GO:0051865,GO:0051984,GO:0060548,GO:0097505" "Y-form DNA binding|damaged DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|replication fork|cytoplasm|centrosome|DNA repair|postreplication repair|protein monoubiquitination|cellular response to DNA damage stimulus|response to UV|protein ubiquitination|nuclear body|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|site of double-strand break|nuclear inclusion body|DNA damage response, detection of DNA damage|identical protein binding|protein-containing complex binding|metal ion binding|protein autoubiquitination|positive regulation of chromosome segregation|negative regulation of cell death|Rad6-Rad18 complex" RAD21 9966.69808 8976.270584 10957.12558 1.220676836 0.287681309 0.392572435 1 124.2121417 158.1541831 5885 RAD21 cohesin complex component "GO:0000775,GO:0000795,GO:0000922,GO:0003682,GO:0005515,GO:0005654,GO:0005694,GO:0005829,GO:0006302,GO:0006310,GO:0006357,GO:0006915,GO:0007064,GO:0007130,GO:0007131,GO:0007275,GO:0008278,GO:0010972,GO:0016020,GO:0016363,GO:0034990,GO:0034991,GO:0045841,GO:0045876,GO:0051301,GO:0071168,GO:1990414" "chromosome, centromeric region|synaptonemal complex|spindle pole|chromatin binding|protein binding|nucleoplasm|chromosome|cytosol|double-strand break repair|DNA recombination|regulation of transcription by RNA polymerase II|apoptotic process|mitotic sister chromatid cohesion|synaptonemal complex assembly|reciprocal meiotic recombination|multicellular organism development|cohesin complex|negative regulation of G2/M transition of mitotic cell cycle|membrane|nuclear matrix|nuclear mitotic cohesin complex|nuclear meiotic cohesin complex|negative regulation of mitotic metaphase/anaphase transition|positive regulation of sister chromatid cohesion|cell division|protein localization to chromatin|replication-born double-strand break repair via sister chromatid exchange" hsa04110 Cell cycle other RAD21L1 16.91279862 11.16451565 22.66108158 2.029741575 1.021296056 0.394570588 1 0.131437316 0.278275747 642636 RAD21 cohesin complex component like 1 "GO:0000795,GO:0000800,GO:0003682,GO:0005634,GO:0005694,GO:0007064,GO:0007130,GO:0007283,GO:0009566,GO:0030893,GO:0034990,GO:0034991,GO:0070197,GO:0072520,GO:1990414" synaptonemal complex|lateral element|chromatin binding|nucleus|chromosome|mitotic sister chromatid cohesion|synaptonemal complex assembly|spermatogenesis|fertilization|meiotic cohesin complex|nuclear mitotic cohesin complex|nuclear meiotic cohesin complex|meiotic attachment of telomere to nuclear envelope|seminiferous tubule development|replication-born double-strand break repair via sister chromatid exchange RAD23A 1906.368133 1642.198757 2170.53751 1.321726436 0.402423606 0.213597306 1 46.5165401 64.13054203 5886 "RAD23 homolog A, nucleotide excision repair protein" "GO:0000502,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006289,GO:0016032,GO:0016579,GO:0019900,GO:0031593,GO:0031648,GO:0032434,GO:0032436,GO:0032991,GO:0034451,GO:0043130,GO:0043161,GO:0043231,GO:0045070,GO:0045787,GO:0070628,GO:1990381" proteasome complex|damaged DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|nucleotide-excision repair|viral process|protein deubiquitination|kinase binding|polyubiquitin modification-dependent protein binding|protein destabilization|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|centriolar satellite|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|positive regulation of viral genome replication|positive regulation of cell cycle|proteasome binding|ubiquitin-specific protease binding "hsa03420,hsa04141" Nucleotide excision repair|Protein processing in endoplasmic reticulum RAD23B 5181.514 5591.39243 4771.635569 0.853389496 -0.228723741 0.477127757 1 65.18975629 58.02866513 5887 "RAD23 homolog B, nucleotide excision repair protein" "GO:0000502,GO:0000715,GO:0000717,GO:0000978,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006289,GO:0006294,GO:0006457,GO:0007283,GO:0016579,GO:0031593,GO:0032434,GO:0043130,GO:0043161,GO:0048568,GO:0070628,GO:0070911,GO:0071942,GO:0098761" "proteasome complex|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|damaged DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytosol|nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|protein folding|spermatogenesis|protein deubiquitination|polyubiquitin modification-dependent protein binding|regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|embryonic organ development|proteasome binding|global genome nucleotide-excision repair|XPC complex|cellular response to interleukin-7" "hsa03420,hsa04141" Nucleotide excision repair|Protein processing in endoplasmic reticulum RAD50 1619.837059 1620.884681 1618.789436 0.998707345 -0.001866114 0.99762245 1 9.924092236 10.33820085 10111 RAD50 double strand break repair protein "GO:0000014,GO:0000019,GO:0000722,GO:0000723,GO:0000724,GO:0000729,GO:0000781,GO:0000794,GO:0003677,GO:0003678,GO:0003691,GO:0005515,GO:0005524,GO:0005654,GO:0006260,GO:0006281,GO:0006302,GO:0006303,GO:0006310,GO:0006974,GO:0007004,GO:0007131,GO:0008408,GO:0016020,GO:0016032,GO:0030674,GO:0030870,GO:0031860,GO:0031954,GO:0032206,GO:0032508,GO:0033674,GO:0035861,GO:0042802,GO:0043047,GO:0046872,GO:0046940,GO:0051880,GO:0070192,GO:0090305,GO:1901796,GO:1904354" "single-stranded DNA endodeoxyribonuclease activity|regulation of mitotic recombination|telomere maintenance via recombination|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|chromosome, telomeric region|condensed nuclear chromosome|DNA binding|DNA helicase activity|double-stranded telomeric DNA binding|protein binding|ATP binding|nucleoplasm|DNA replication|DNA repair|double-strand break repair|double-strand break repair via nonhomologous end joining|DNA recombination|cellular response to DNA damage stimulus|telomere maintenance via telomerase|reciprocal meiotic recombination|3'-5' exonuclease activity|membrane|viral process|protein-macromolecule adaptor activity|Mre11 complex|telomeric 3' overhang formation|positive regulation of protein autophosphorylation|positive regulation of telomere maintenance|DNA duplex unwinding|positive regulation of kinase activity|site of double-strand break|identical protein binding|single-stranded telomeric DNA binding|metal ion binding|nucleoside monophosphate phosphorylation|G-quadruplex DNA binding|chromosome organization involved in meiotic cell cycle|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator|negative regulation of telomere capping" "hsa03440,hsa03450,hsa04218" Homologous recombination|Non-homologous end-joining|Cellular senescence RAD51 278.9443906 243.5894324 314.2993489 1.290283186 0.367687737 0.449016976 1 4.429782915 5.961882486 5888 RAD51 recombinase "GO:0000150,GO:0000228,GO:0000722,GO:0000724,GO:0000730,GO:0000781,GO:0000785,GO:0000793,GO:0000794,GO:0000800,GO:0001932,GO:0003682,GO:0003690,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005815,GO:0006268,GO:0006281,GO:0006310,GO:0006312,GO:0006974,GO:0007131,GO:0008022,GO:0008094,GO:0009636,GO:0010165,GO:0010212,GO:0010569,GO:0010833,GO:0016605,GO:0017116,GO:0019899,GO:0031297,GO:0032991,GO:0035861,GO:0036297,GO:0042148,GO:0042493,GO:0042802,GO:0048471,GO:0051106,GO:0051321,GO:0070182,GO:0070192,GO:0070317,GO:0071479,GO:0071480,GO:0072711,GO:0072719,GO:0072757,GO:1904631,GO:1990414,GO:1990426" "recombinase activity|nuclear chromosome|telomere maintenance via recombination|double-strand break repair via homologous recombination|DNA recombinase assembly|chromosome, telomeric region|chromatin|condensed chromosome|condensed nuclear chromosome|lateral element|regulation of protein phosphorylation|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|microtubule organizing center|DNA unwinding involved in DNA replication|DNA repair|DNA recombination|mitotic recombination|cellular response to DNA damage stimulus|reciprocal meiotic recombination|protein C-terminus binding|DNA-dependent ATPase activity|response to toxic substance|response to X-ray|response to ionizing radiation|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomere lengthening|PML body|single-stranded DNA helicase activity|enzyme binding|replication fork processing|protein-containing complex|site of double-strand break|interstrand cross-link repair|strand invasion|response to drug|identical protein binding|perinuclear region of cytoplasm|positive regulation of DNA ligation|meiotic cell cycle|DNA polymerase binding|chromosome organization involved in meiotic cell cycle|negative regulation of G0 to G1 transition|cellular response to ionizing radiation|cellular response to gamma radiation|cellular response to hydroxyurea|cellular response to cisplatin|cellular response to camptothecin|response to glucoside|replication-born double-strand break repair via sister chromatid exchange|mitotic recombination-dependent replication fork processing" "hsa03440,hsa03460,hsa05200,hsa05212" Homologous recombination|Fanconi anemia pathway|Pathways in cancer|Pancreatic cancer RAD51AP1 530.4998159 433.3861985 627.6134333 1.448162022 0.534223021 0.18482326 1 10.14770322 15.32854174 10635 RAD51 associated protein 1 "GO:0000217,GO:0000724,GO:0000781,GO:0000785,GO:0003677,GO:0003690,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006281,GO:0006974,GO:0010569,GO:0010845,GO:0032991,GO:0036297,GO:0051321,GO:0062037,GO:0071479,GO:1905168" "DNA secondary structure binding|double-strand break repair via homologous recombination|chromosome, telomeric region|chromatin|DNA binding|double-stranded DNA binding|single-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|DNA repair|cellular response to DNA damage stimulus|regulation of double-strand break repair via homologous recombination|positive regulation of reciprocal meiotic recombination|protein-containing complex|interstrand cross-link repair|meiotic cell cycle|D-loop DNA binding|cellular response to ionizing radiation|positive regulation of double-strand break repair via homologous recombination" RAD51B 265.6109079 275.0530674 256.1687483 0.931342998 -0.10261551 0.841305697 1 1.502585216 1.459703653 5890 RAD51 paralog B "GO:0000400,GO:0000724,GO:0003677,GO:0003690,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0006281,GO:0006310,GO:0007131,GO:0007596,GO:0008094,GO:0010971,GO:0033063" four-way junction DNA binding|double-strand break repair via homologous recombination|DNA binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|DNA repair|DNA recombination|reciprocal meiotic recombination|blood coagulation|DNA-dependent ATPase activity|positive regulation of G2/M transition of mitotic cell cycle|Rad51B-Rad51C-Rad51D-XRCC2 complex hsa03440 Homologous recombination RAD51C 349.753776 369.4439725 330.0635795 0.893406319 -0.162611636 0.722564559 1 7.865083601 7.32939779 5889 RAD51 paralog C "GO:0000400,GO:0000707,GO:0000722,GO:0000724,GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005739,GO:0005829,GO:0006281,GO:0006310,GO:0007062,GO:0007066,GO:0007131,GO:0007141,GO:0007283,GO:0007596,GO:0008094,GO:0008821,GO:0010971,GO:0030054,GO:0033063,GO:0033065,GO:0043231,GO:0048471,GO:0048476" four-way junction DNA binding|meiotic DNA recombinase assembly|telomere maintenance via recombination|double-strand break repair via homologous recombination|DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|cytoplasm|mitochondrion|cytosol|DNA repair|DNA recombination|sister chromatid cohesion|female meiosis sister chromatid cohesion|reciprocal meiotic recombination|male meiosis I|spermatogenesis|blood coagulation|DNA-dependent ATPase activity|crossover junction endodeoxyribonuclease activity|positive regulation of G2/M transition of mitotic cell cycle|cell junction|Rad51B-Rad51C-Rad51D-XRCC2 complex|Rad51C-XRCC3 complex|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|Holliday junction resolvase complex "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway RAD51D 696.8744065 626.2278325 767.5209805 1.225625788 0.293518558 0.438227952 1 3.158043465 4.037308377 5892 RAD51 paralog D "GO:0000400,GO:0000722,GO:0000723,GO:0000724,GO:0000781,GO:0003677,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005813,GO:0006281,GO:0007131,GO:0008094,GO:0033063,GO:0036297,GO:0042148,GO:0043015,GO:0051726" "four-way junction DNA binding|telomere maintenance via recombination|telomere maintenance|double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|cytoplasm|centrosome|DNA repair|reciprocal meiotic recombination|DNA-dependent ATPase activity|Rad51B-Rad51C-Rad51D-XRCC2 complex|interstrand cross-link repair|strand invasion|gamma-tubulin binding|regulation of cell cycle" hsa03440 Homologous recombination RAD52 344.3321001 402.9375194 285.7266808 0.709109147 -0.495920388 0.274134978 1 4.207703893 3.112247933 5893 "RAD52 homolog, DNA repair protein" "GO:0000724,GO:0000730,GO:0003677,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0006302,GO:0006310,GO:0006312,GO:0006974,GO:0010792,GO:0032991,GO:0032993,GO:0034599,GO:0042802,GO:0045002,GO:2000819" double-strand break repair via homologous recombination|DNA recombinase assembly|DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|double-strand break repair|DNA recombination|mitotic recombination|cellular response to DNA damage stimulus|DNA double-strand break processing involved in repair via single-strand annealing|protein-containing complex|protein-DNA complex|cellular response to oxidative stress|identical protein binding|double-strand break repair via single-strand annealing|regulation of nucleotide-excision repair hsa03440 Homologous recombination RAD54B 778.2153824 663.7812033 892.6495614 1.344794877 0.427386133 0.247488215 1 3.971432518 5.570820475 25788 RAD54 homolog B "GO:0000724,GO:0003677,GO:0003678,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0006312,GO:0007131,GO:0008340,GO:0010212,GO:0015616,GO:0032508,GO:0042493" double-strand break repair via homologous recombination|DNA binding|DNA helicase activity|RNA helicase activity|protein binding|ATP binding|nucleus|mitotic recombination|reciprocal meiotic recombination|determination of adult lifespan|response to ionizing radiation|DNA translocase activity|DNA duplex unwinding|response to drug hsa03440 Homologous recombination RAD54L 707.4005538 604.9137572 809.8873504 1.33884763 0.420991782 0.264137439 1 9.753819736 13.62140196 8438 RAD54 like "GO:0000733,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0007131,GO:0008340,GO:0010212,GO:0015616,GO:0032508,GO:0032991,GO:0036310,GO:0042493,GO:0045003,GO:0046872,GO:0051321" DNA strand renaturation|DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|DNA recombination|reciprocal meiotic recombination|determination of adult lifespan|response to ionizing radiation|DNA translocase activity|DNA duplex unwinding|protein-containing complex|annealing helicase activity|response to drug|double-strand break repair via synthesis-dependent strand annealing|metal ion binding|meiotic cell cycle hsa03440 Homologous recombination RAD54L2 1186.153699 1104.272094 1268.035304 1.148299691 0.199499216 0.561233696 1 5.589953613 6.695443997 23132 RAD54 like 2 "GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0032508" DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|DNA duplex unwinding RAD9A 194.5315769 164.4228669 224.640287 1.36623507 0.45020573 0.409515214 1 3.085379088 4.396933429 5883 RAD9 checkpoint clamp component A "GO:0000076,GO:0000077,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0006974,GO:0008408,GO:0008853,GO:0017124,GO:0019899,GO:0019901,GO:0030896,GO:0031573,GO:0042826,GO:0071479,GO:0090305,GO:1901796" DNA replication checkpoint|DNA damage checkpoint|protein binding|nucleus|nucleoplasm|DNA replication|DNA repair|cellular response to DNA damage stimulus|3'-5' exonuclease activity|exodeoxyribonuclease III activity|SH3 domain binding|enzyme binding|protein kinase binding|checkpoint clamp complex|intra-S DNA damage checkpoint|histone deacetylase binding|cellular response to ionizing radiation|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence RAD9B 23.04707175 26.38885518 19.70528833 0.74672767 -0.421345905 0.719107993 1 0.289411525 0.225420804 144715 RAD9 checkpoint clamp component B "GO:0000076,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0008408,GO:0030896,GO:0031573,GO:0071479,GO:0090305,GO:1901796" DNA replication checkpoint|protein binding|nucleus|nucleoplasm|DNA replication|DNA repair|3'-5' exonuclease activity|checkpoint clamp complex|intra-S DNA damage checkpoint|cellular response to ionizing radiation|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence RADX 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.041432514 0 55086 "RPA1 related single stranded DNA binding protein, X-linked" "GO:0003697,GO:0003723,GO:0005515,GO:0005657,GO:0006282,GO:0016607,GO:2000042" single-stranded DNA binding|RNA binding|protein binding|replication fork|regulation of DNA repair|nuclear speck|negative regulation of double-strand break repair via homologous recombination RAE1 1721.709243 1782.26268 1661.155806 0.932048808 -0.10152259 0.756950013 1 35.38428746 34.40052254 8480 ribonucleic acid export 1 "GO:0000972,GO:0001650,GO:0003723,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0007049,GO:0008017,GO:0016032,GO:0016925,GO:0019083,GO:0043130,GO:0043657,GO:0051301,GO:0060236,GO:0060964,GO:0075733,GO:0097431,GO:1900034" transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|fibrillar center|RNA binding|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|cell cycle|microtubule binding|viral process|protein sumoylation|viral transcription|ubiquitin binding|host cell|cell division|regulation of mitotic spindle organization|regulation of gene silencing by miRNA|intracellular transport of virus|mitotic spindle pole|regulation of cellular response to heat "hsa03013,hsa05014,hsa05164" RNA transport|Amyotrophic lateral sclerosis|Influenza A RAET1E 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.029201253 0.019712048 135250 retinoic acid early transcript 1E "GO:0005515,GO:0005615,GO:0005886,GO:0006955,GO:0009897,GO:0016021,GO:0042267,GO:0045954,GO:0046703,GO:0050776" protein binding|extracellular space|plasma membrane|immune response|external side of plasma membrane|integral component of membrane|natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity RAET1G 16.10568351 23.34398727 8.867379749 0.379857119 -1.396471236 0.247723797 1 0.52290606 0.207185747 353091 retinoic acid early transcript 1G "GO:0002729,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0006955,GO:0009897,GO:0016021,GO:0016032,GO:0031225,GO:0042267,GO:0046703" positive regulation of natural killer cell cytokine production|protein binding|extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|immune response|external side of plasma membrane|integral component of membrane|viral process|anchored component of membrane|natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding hsa04650 Natural killer cell mediated cytotoxicity RAET1L 7.523095107 9.134603715 5.911586499 0.64716398 -0.627796782 0.748279434 1 0.343711332 0.232019303 154064 retinoic acid early transcript 1L "GO:0002376,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0006955,GO:0009897,GO:0016032,GO:0031225" immune system process|protein binding|extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|immune response|external side of plasma membrane|viral process|anchored component of membrane hsa04650 Natural killer cell mediated cytotoxicity RAF1 3566.124485 3432.581085 3699.667884 1.07780932 0.108101967 0.734521617 1 48.60165573 54.63977837 5894 "Raf-1 proto-oncogene, serine/threonine kinase" "GO:0000165,GO:0000186,GO:0001666,GO:0002223,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005741,GO:0005794,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0007165,GO:0007190,GO:0007507,GO:0008179,GO:0008285,GO:0010856,GO:0016607,GO:0019899,GO:0030154,GO:0030168,GO:0030878,GO:0031143,GO:0031267,GO:0031333,GO:0031434,GO:0033138,GO:0034220,GO:0035019,GO:0035023,GO:0035773,GO:0035994,GO:0042060,GO:0042802,GO:0042981,GO:0043066,GO:0043154,GO:0044877,GO:0045104,GO:0045595,GO:0045944,GO:0046872,GO:0048011,GO:0048538,GO:0060324,GO:0071550,GO:0106310,GO:0106311,GO:1902042,GO:2000145" MAPK cascade|activation of MAPKK activity|response to hypoxia|stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial outer membrane|Golgi apparatus|cytosol|plasma membrane|protein phosphorylation|apoptotic process|signal transduction|activation of adenylate cyclase activity|heart development|adenylate cyclase binding|negative regulation of cell population proliferation|adenylate cyclase activator activity|nuclear speck|enzyme binding|cell differentiation|platelet activation|thyroid gland development|pseudopodium|small GTPase binding|negative regulation of protein-containing complex assembly|mitogen-activated protein kinase kinase binding|positive regulation of peptidyl-serine phosphorylation|ion transmembrane transport|somatic stem cell population maintenance|regulation of Rho protein signal transduction|insulin secretion involved in cellular response to glucose stimulus|response to muscle stretch|wound healing|identical protein binding|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein-containing complex binding|intermediate filament cytoskeleton organization|regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|neurotrophin TRK receptor signaling pathway|thymus development|face development|death-inducing signaling complex assembly|protein serine kinase activity|protein threonine kinase activity|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of cell motility "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04270,hsa04360,hsa04370,hsa04371,hsa04510,hsa04540,hsa04550,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04720,hsa04722,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04929,hsa04935,hsa05010,hsa05022,hsa05034,hsa05132,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Long-term potentiation|Neurotrophin signaling pathway|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Growth hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Salmonella infection|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" RAG1 29.92907689 25.37389921 34.48425458 1.359044359 0.442592546 0.673478543 1 0.182361073 0.258512591 5896 recombination activating 1 "GO:0002250,GO:0002331,GO:0003677,GO:0004519,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0006310,GO:0006955,GO:0008270,GO:0008542,GO:0010390,GO:0030183,GO:0033077,GO:0033151,GO:0042393,GO:0042803,GO:0043029,GO:0043154,GO:0043565,GO:0045582,GO:0046872,GO:0048538,GO:0051865,GO:0061630,GO:0070244,GO:0090305,GO:0097519,GO:1905347,GO:1990238,GO:2000822" adaptive immune response|pre-B cell allelic exclusion|DNA binding|endonuclease activity|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|DNA recombination|immune response|zinc ion binding|visual learning|histone monoubiquitination|B cell differentiation|T cell differentiation in thymus|V(D)J recombination|histone binding|protein homodimerization activity|T cell homeostasis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|sequence-specific DNA binding|positive regulation of T cell differentiation|metal ion binding|thymus development|protein autoubiquitination|ubiquitin protein ligase activity|negative regulation of thymocyte apoptotic process|nucleic acid phosphodiester bond hydrolysis|DNA recombinase complex|endodeoxyribonuclease complex|double-stranded DNA endodeoxyribonuclease activity|regulation of behavioral fear response "hsa04068,hsa05340" FoxO signaling pathway|Primary immunodeficiency RAI1 2024.232432 2122.27293 1926.191934 0.907608021 -0.139858736 0.664730807 1 11.25268394 10.65296195 10743 retinoic acid induced 1 "GO:0001501,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0032922,GO:0040015,GO:0045893,GO:0046872" "skeletal system development|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|circadian regulation of gene expression|negative regulation of multicellular organism growth|positive regulation of transcription, DNA-templated|metal ion binding" RAI14 7468.030655 9613.662932 5322.398378 0.553628561 -0.853009722 0.009975268 0.419890621 69.19114858 39.95627161 26064 retinoic acid induced 14 "GO:0001650,GO:0003779,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0005938,GO:0007283,GO:0030054,GO:0030154" fibrillar center|actin binding|protein binding|nucleoplasm|cytosol|cytoskeleton|cell cortex|spermatogenesis|cell junction|cell differentiation RALA 1257.455716 1230.126634 1284.784799 1.044432958 0.06271989 0.855528544 1 15.24757082 16.61105273 5898 RAS like proto-oncogene A "GO:0001843,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0005925,GO:0006887,GO:0006935,GO:0007049,GO:0007165,GO:0007265,GO:0009986,GO:0017022,GO:0017157,GO:0019003,GO:0030139,GO:0030659,GO:0031532,GO:0031625,GO:0031755,GO:0032154,GO:0035722,GO:0051117,GO:0051301,GO:0051491,GO:0051665,GO:0061024,GO:0070062,GO:0090543" neural tube closure|GTPase activity|protein binding|GTP binding|plasma membrane|focal adhesion|exocytosis|chemotaxis|cell cycle|signal transduction|Ras protein signal transduction|cell surface|myosin binding|regulation of exocytosis|GDP binding|endocytic vesicle|cytoplasmic vesicle membrane|actin cytoskeleton reorganization|ubiquitin protein ligase binding|Edg-2 lysophosphatidic acid receptor binding|cleavage furrow|interleukin-12-mediated signaling pathway|ATPase binding|cell division|positive regulation of filopodium assembly|membrane raft localization|membrane organization|extracellular exosome|Flemming body "hsa04014,hsa04015,hsa04072,hsa05132,hsa05200,hsa05210,hsa05212" Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Salmonella infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer RALB 798.4227055 731.7832532 865.0621577 1.182128935 0.241387399 0.512241165 1 13.84986554 17.07758024 5899 RAS like proto-oncogene B "GO:0001928,GO:0001934,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0006915,GO:0007049,GO:0007165,GO:0007265,GO:0009267,GO:0019003,GO:0030496,GO:0031625,GO:0032091,GO:0032092,GO:0051117,GO:0051301,GO:0060178,GO:0070062,GO:0071360,GO:0071902,GO:2000786" regulation of exocyst assembly|positive regulation of protein phosphorylation|GTPase activity|protein binding|GTP binding|plasma membrane|apoptotic process|cell cycle|signal transduction|Ras protein signal transduction|cellular response to starvation|GDP binding|midbody|ubiquitin protein ligase binding|negative regulation of protein binding|positive regulation of protein binding|ATPase binding|cell division|regulation of exocyst localization|extracellular exosome|cellular response to exogenous dsRNA|positive regulation of protein serine/threonine kinase activity|positive regulation of autophagosome assembly "hsa04014,hsa04015,hsa04072,hsa05200,hsa05210,hsa05212" Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Pathways in cancer|Colorectal cancer|Pancreatic cancer RALBP1 2457.716362 2153.736565 2761.69616 1.282281317 0.358712807 0.261252109 1 24.90960472 33.3170147 10928 ralA binding protein 1 "GO:0005096,GO:0005515,GO:0005829,GO:0006897,GO:0006935,GO:0007264,GO:0016020,GO:0022857,GO:0031267,GO:0042626,GO:0042910,GO:0043087,GO:0043547,GO:0051056,GO:0055085,GO:1900753,GO:1990961" GTPase activator activity|protein binding|cytosol|endocytosis|chemotaxis|small GTPase mediated signal transduction|membrane|transmembrane transporter activity|small GTPase binding|ATPase-coupled transmembrane transporter activity|xenobiotic transmembrane transporter activity|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|transmembrane transport|doxorubicin transport|xenobiotic detoxification by transmembrane export across the plasma membrane "hsa04014,hsa05200,hsa05212" Ras signaling pathway|Pathways in cancer|Pancreatic cancer RALGAPA1 1069.135363 1052.509339 1085.761387 1.031593114 0.044874049 0.900107659 1 3.954442507 4.255098621 253959 Ral GTPase activating protein catalytic subunit alpha 1 "GO:0005096,GO:0005634,GO:0005737,GO:0046982,GO:0051056,GO:0090630" GTPase activator activity|nucleus|cytoplasm|protein heterodimerization activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity RALGAPA2 1216.737228 1342.786746 1090.687709 0.812256832 -0.299992121 0.379678689 1 5.315986213 4.50394573 57186 Ral GTPase activating protein catalytic subunit alpha 2 "GO:0005096,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0046982,GO:0051056,GO:0090630" GTPase activator activity|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|protein heterodimerization activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity RALGAPB 3751.867116 3366.608947 4137.125285 1.228870163 0.297332495 0.350476764 1 19.09799132 24.47989896 57148 Ral GTPase activating protein non-catalytic subunit beta "GO:0005096,GO:0005515,GO:0046982,GO:0051056,GO:0090630" GTPase activator activity|protein binding|protein heterodimerization activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity RALGDS 1120.126137 1103.257138 1136.995137 1.030580359 0.043457002 0.902483387 1 12.66169997 13.61099296 5900 ral guanine nucleotide dissociation stimulator "GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0005903,GO:0007265,GO:0030695,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|brush border|Ras protein signal transduction|GTPase regulator activity|regulation of catalytic activity "hsa04014,hsa04015,hsa04072,hsa05200,hsa05210,hsa05212,hsa05231" Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer RALGPS1 138.2284906 87.28621328 189.170768 2.167246818 1.115863465 0.068407657 1 0.425685005 0.962304808 9649 Ral GEF with PH domain and SH3 binding motif 1 "GO:0005085,GO:0005575,GO:0005737,GO:0005886,GO:0007264,GO:0032485,GO:0035556,GO:0050790" guanyl-nucleotide exchange factor activity|cellular_component|cytoplasm|plasma membrane|small GTPase mediated signal transduction|regulation of Ral protein signal transduction|intracellular signal transduction|regulation of catalytic activity RALGPS2 1186.827202 1082.958018 1290.696386 1.19182495 0.253172354 0.460424931 1 21.43337365 26.64519713 55103 Ral GEF with PH domain and SH3 binding motif 2 "GO:0005085,GO:0005515,GO:0005737,GO:0005886,GO:0007264,GO:0032485,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|plasma membrane|small GTPase mediated signal transduction|regulation of Ral protein signal transduction|regulation of catalytic activity RALY 5369.883588 4795.666951 5944.100225 1.239473109 0.309726972 0.33667503 1 106.9500718 138.27196 22913 RALY heterogeneous nuclear ribonucleoprotein "GO:0000398,GO:0003712,GO:0003723,GO:0005515,GO:0005634,GO:0006355,GO:0042632,GO:0071013,GO:1903506" "mRNA splicing, via spliceosome|transcription coregulator activity|RNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|cholesterol homeostasis|catalytic step 2 spliceosome|regulation of nucleic acid-templated transcription" RAMAC 502.3373864 528.7920595 475.8827132 0.899943001 -0.152094465 0.712446148 1 17.1127491 16.06388982 83640 RNA guanine-7 methyltransferase activating subunit "GO:0003723,GO:0004482,GO:0005515,GO:0005634,GO:0005654,GO:0005845,GO:0006370,GO:0008047,GO:0031533,GO:0032259,GO:0036031,GO:0050790,GO:0106005" RNA binding|mRNA (guanine-N7-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|mRNA cap binding complex|7-methylguanosine mRNA capping|enzyme activator activity|mRNA cap methyltransferase complex|methylation|recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex|regulation of catalytic activity|RNA 5'-cap (guanine-N7)-methylation RAMP1 92.05467503 96.420817 87.68853307 0.909435699 -0.136956459 0.85814993 1 1.818084225 1.724653786 10267 receptor activity modifying protein 1 "GO:0001525,GO:0001635,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006816,GO:0006886,GO:0007186,GO:0007189,GO:0008277,GO:0009986,GO:0015026,GO:0015031,GO:0031623,GO:0032092,GO:0032870,GO:0043235,GO:0060050,GO:0072659,GO:0097643,GO:0097647,GO:0150056,GO:1990406,GO:1990407,GO:1990408" angiogenesis|calcitonin gene-related peptide receptor activity|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|calcium ion transport|intracellular protein transport|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|cell surface|coreceptor activity|protein transport|receptor internalization|positive regulation of protein binding|cellular response to hormone stimulus|receptor complex|positive regulation of protein glycosylation|protein localization to plasma membrane|amylin receptor activity|amylin receptor signaling pathway|amylin receptor complex 1|CGRP receptor complex|calcitonin gene-related peptide binding|calcitonin gene-related peptide receptor signaling pathway hsa04270 Vascular smooth muscle contraction RAN 8753.865791 9180.276734 8327.454849 0.907102813 -0.140662017 0.672660106 1 168.4596487 159.3926658 5901 "RAN, member RAS oncogene family" "GO:0000054,GO:0000055,GO:0000056,GO:0000070,GO:0000278,GO:0000287,GO:0000785,GO:0003682,GO:0003723,GO:0003924,GO:0005049,GO:0005515,GO:0005525,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0005829,GO:0006259,GO:0006409,GO:0006606,GO:0006611,GO:0007052,GO:0010586,GO:0016020,GO:0016032,GO:0019003,GO:0030496,GO:0032092,GO:0032991,GO:0035281,GO:0042307,GO:0042470,GO:0042565,GO:0043657,GO:0045296,GO:0045540,GO:0046039,GO:0046982,GO:0051301,GO:0055037,GO:0061015,GO:0070062,GO:0070883,GO:0075733,GO:0090543,GO:1902570" ribosomal subunit export from nucleus|ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|mitotic sister chromatid segregation|mitotic cell cycle|magnesium ion binding|chromatin|chromatin binding|RNA binding|GTPase activity|nuclear export signal receptor activity|protein binding|GTP binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|nucleolus|cytoplasm|centriole|cytosol|DNA metabolic process|tRNA export from nucleus|protein import into nucleus|protein export from nucleus|mitotic spindle organization|miRNA metabolic process|membrane|viral process|GDP binding|midbody|positive regulation of protein binding|protein-containing complex|pre-miRNA export from nucleus|positive regulation of protein import into nucleus|melanosome|RNA nuclear export complex|host cell|cadherin binding|regulation of cholesterol biosynthetic process|GTP metabolic process|protein heterodimerization activity|cell division|recycling endosome|snRNA import into nucleus|extracellular exosome|pre-miRNA binding|intracellular transport of virus|Flemming body|protein localization to nucleolus "hsa03008,hsa03013,hsa05166" Ribosome biogenesis in eukaryotes|RNA transport|Human T-cell leukemia virus 1 infection RANBP1 3473.255767 3617.303071 3329.208464 0.920356519 -0.119735268 0.707066212 1 69.1595468 66.39328564 5902 RAN binding protein 1 "GO:0005092,GO:0005096,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005737,GO:0005813,GO:0005829,GO:0007165,GO:0016032,GO:0043547,GO:0045296,GO:0046604,GO:0046907" GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|nucleus|nuclear envelope|nuclear pore|cytoplasm|centrosome|cytosol|signal transduction|viral process|positive regulation of GTPase activity|cadherin binding|positive regulation of mitotic centrosome separation|intracellular transport "hsa05166,hsa05203" Human T-cell leukemia virus 1 infection|Viral carcinogenesis RANBP10 576.7639439 598.8240213 554.7038665 0.926322002 -0.110414313 0.782925453 1 4.700608208 4.541841393 57610 RAN binding protein 10 "GO:0000151,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007010,GO:0007166" ubiquitin ligase complex|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton organization|cell surface receptor signaling pathway RANBP17 192.6946601 173.5574706 211.8318496 1.220528559 0.287506053 0.602479217 1 1.00377682 1.277912264 64901 RAN binding protein 17 "GO:0005049,GO:0005525,GO:0005643,GO:0005737,GO:0006606,GO:0006611,GO:0051028" nuclear export signal receptor activity|GTP binding|nuclear pore|cytoplasm|protein import into nucleus|protein export from nucleus|mRNA transport RANBP2 3015.874597 3366.608947 2665.140247 0.791639388 -0.337084699 0.289499725 1 12.95743343 10.69947111 5903 RAN binding protein 2 "GO:0000413,GO:0001975,GO:0003723,GO:0003755,GO:0005096,GO:0005515,GO:0005635,GO:0005642,GO:0005643,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006110,GO:0006111,GO:0006406,GO:0006409,GO:0006457,GO:0006607,GO:0016018,GO:0016020,GO:0016032,GO:0016925,GO:0019083,GO:0019789,GO:0031267,GO:0031965,GO:0033133,GO:0042405,GO:0043231,GO:0043547,GO:0043657,GO:0044614,GO:0044615,GO:0044877,GO:0046872,GO:0051642,GO:0060964,GO:0075733,GO:1900034,GO:1990723" protein peptidyl-prolyl isomerization|response to amphetamine|RNA binding|peptidyl-prolyl cis-trans isomerase activity|GTPase activator activity|protein binding|nuclear envelope|annulate lamellae|nuclear pore|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of glycolytic process|regulation of gluconeogenesis|mRNA export from nucleus|tRNA export from nucleus|protein folding|NLS-bearing protein import into nucleus|cyclosporin A binding|membrane|viral process|protein sumoylation|viral transcription|SUMO transferase activity|small GTPase binding|nuclear membrane|positive regulation of glucokinase activity|nuclear inclusion body|intracellular membrane-bounded organelle|positive regulation of GTPase activity|host cell|nuclear pore cytoplasmic filaments|nuclear pore nuclear basket|protein-containing complex binding|metal ion binding|centrosome localization|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat|cytoplasmic periphery of the nuclear pore complex "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis RANBP3 906.3670583 937.8193148 874.9148019 0.932924699 -0.100167456 0.782284096 1 13.8475918 13.47524821 8498 RAN binding protein 3 "GO:0005096,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0006611,GO:0043547,GO:0070412" GTPase activator activity|protein binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|protein export from nucleus|positive regulation of GTPase activity|R-SMAD binding hsa05166 Human T-cell leukemia virus 1 infection RANBP6 854.9551594 925.6398432 784.2704756 0.847273895 -0.239099675 0.510496686 1 10.19138969 9.00685485 26953 RAN binding protein 6 "GO:0005515,GO:0005634,GO:0005737,GO:0006606,GO:0008139,GO:0061608" protein binding|nucleus|cytoplasm|protein import into nucleus|nuclear localization sequence binding|nuclear import signal receptor activity RANBP9 805.3438047 800.800259 809.8873504 1.011347513 0.016278812 0.968315389 1 12.03135807 12.69202716 10048 RAN binding protein 9 "GO:0000151,GO:0000165,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005875,GO:0005886,GO:0007010,GO:0007020,GO:0007166,GO:0007411,GO:0016604,GO:0019899,GO:0065003,GO:0070373,GO:1902993" ubiquitin ligase complex|MAPK cascade|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|microtubule associated complex|plasma membrane|cytoskeleton organization|microtubule nucleation|cell surface receptor signaling pathway|axon guidance|nuclear body|enzyme binding|protein-containing complex assembly|negative regulation of ERK1 and ERK2 cascade|positive regulation of amyloid precursor protein catabolic process RANGAP1 8415.974528 8510.405795 8321.543262 0.977808046 -0.032376818 0.922598629 1 50.20056261 51.20096199 5905 Ran GTPase activating protein 1 "GO:0000776,GO:0000777,GO:0003723,GO:0005096,GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0016235,GO:0016925,GO:0030425,GO:0031267,GO:0031625,GO:0031965,GO:0043231,GO:0044614,GO:0045296,GO:0046826,GO:0048471,GO:0048678,GO:0072686,GO:0090630,GO:1904115,GO:1904117,GO:1990723" kinetochore|condensed chromosome kinetochore|RNA binding|GTPase activator activity|protein binding|nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|cytosol|signal transduction|aggresome|protein sumoylation|dendrite|small GTPase binding|ubiquitin protein ligase binding|nuclear membrane|intracellular membrane-bounded organelle|nuclear pore cytoplasmic filaments|cadherin binding|negative regulation of protein export from nucleus|perinuclear region of cytoplasm|response to axon injury|mitotic spindle|activation of GTPase activity|axon cytoplasm|cellular response to vasopressin|cytoplasmic periphery of the nuclear pore complex hsa03013 RNA transport RANGRF 466.7396986 452.6703619 480.8090353 1.06216151 0.087003156 0.838729347 1 27.58863647 30.5658675 29098 RAN guanine nucleotide release factor "GO:0002027,GO:0003254,GO:0005085,GO:0005634,GO:0005654,GO:0005737,GO:0005791,GO:0005829,GO:0005886,GO:0005901,GO:0006888,GO:0014704,GO:0017080,GO:0031267,GO:0032527,GO:0042391,GO:0044325,GO:0048471,GO:0050790,GO:0090226,GO:0098905,GO:0098909,GO:1900825,GO:1902305,GO:1903078,GO:2000010,GO:2000649" regulation of heart rate|regulation of membrane depolarization|guanyl-nucleotide exchange factor activity|nucleus|nucleoplasm|cytoplasm|rough endoplasmic reticulum|cytosol|plasma membrane|caveola|endoplasmic reticulum to Golgi vesicle-mediated transport|intercalated disc|sodium channel regulator activity|small GTPase binding|protein exit from endoplasmic reticulum|regulation of membrane potential|ion channel binding|perinuclear region of cytoplasm|regulation of catalytic activity|regulation of microtubule nucleation by Ran protein signal transduction|regulation of bundle of His cell action potential|regulation of cardiac muscle cell action potential involved in regulation of contraction|regulation of membrane depolarization during cardiac muscle cell action potential|regulation of sodium ion transmembrane transport|positive regulation of protein localization to plasma membrane|positive regulation of protein localization to cell surface|regulation of sodium ion transmembrane transporter activity RAP1A 679.8846574 643.4820839 716.2872308 1.113142461 0.154638243 0.686334551 1 5.527492789 6.417928344 5906 "RAP1A, member of RAS oncogene family" "GO:0003924,GO:0005085,GO:0005515,GO:0005525,GO:0005737,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0007399,GO:0009743,GO:0010976,GO:0019003,GO:0030033,GO:0030054,GO:0031267,GO:0032045,GO:0032486,GO:0032966,GO:0035579,GO:0035690,GO:0038180,GO:0043005,GO:0043312,GO:0043547,GO:0044877,GO:0045335,GO:0045860,GO:0046326,GO:0048471,GO:0050796,GO:0061028,GO:0070062,GO:0070374,GO:0071320,GO:0072659,GO:0097327,GO:0097421,GO:0098696,GO:0098978,GO:1901888,GO:1905451,GO:1990090,GO:2000301,GO:2001214" GTPase activity|guanyl-nucleotide exchange factor activity|protein binding|GTP binding|cytoplasm|early endosome|late endosome|cytosol|plasma membrane|nervous system development|response to carbohydrate|positive regulation of neuron projection development|GDP binding|microvillus assembly|cell junction|small GTPase binding|guanyl-nucleotide exchange factor complex|Rap protein signal transduction|negative regulation of collagen biosynthetic process|specific granule membrane|cellular response to drug|nerve growth factor signaling pathway|neuron projection|neutrophil degranulation|positive regulation of GTPase activity|protein-containing complex binding|phagocytic vesicle|positive regulation of protein kinase activity|positive regulation of glucose import|perinuclear region of cytoplasm|regulation of insulin secretion|establishment of endothelial barrier|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|protein localization to plasma membrane|response to antineoplastic agent|liver regeneration|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|glutamatergic synapse|regulation of cell junction assembly|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|cellular response to nerve growth factor stimulus|negative regulation of synaptic vesicle exocytosis|positive regulation of vasculogenesis "hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04510,hsa04530,hsa04611,hsa04670,hsa04720,hsa04722,hsa04934,hsa04972,hsa05211" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Long-term potentiation|Neurotrophin signaling pathway|Cushing syndrome|Pancreatic secretion|Renal cell carcinoma RAP1B 2625.478291 2542.464701 2708.491881 1.065301666 0.091262022 0.775410333 1 9.62527043 10.69550946 5908 "RAP1B, member of RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005811,GO:0005829,GO:0005886,GO:0005911,GO:0008283,GO:0009743,GO:0016020,GO:0019003,GO:0030033,GO:0032486,GO:0033625,GO:0035577,GO:0035690,GO:0035722,GO:0043312,GO:0044877,GO:0045121,GO:0045955,GO:0061028,GO:0070062,GO:0070374,GO:0071320,GO:0097211,GO:1901888,GO:2000114,GO:2000301" GTPase activity|protein binding|GTP binding|lipid droplet|cytosol|plasma membrane|cell-cell junction|cell population proliferation|response to carbohydrate|membrane|GDP binding|microvillus assembly|Rap protein signal transduction|positive regulation of integrin activation|azurophil granule membrane|cellular response to drug|interleukin-12-mediated signaling pathway|neutrophil degranulation|protein-containing complex binding|membrane raft|negative regulation of calcium ion-dependent exocytosis|establishment of endothelial barrier|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|cellular response to gonadotropin-releasing hormone|regulation of cell junction assembly|regulation of establishment of cell polarity|negative regulation of synaptic vesicle exocytosis "hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04510,hsa04611,hsa04670,hsa04720,hsa04722,hsa04934,hsa04972,hsa05211" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Platelet activation|Leukocyte transendothelial migration|Long-term potentiation|Neurotrophin signaling pathway|Cushing syndrome|Pancreatic secretion|Renal cell carcinoma RAP1GAP 4.985705186 4.059823873 5.911586499 1.456118956 0.542128219 0.871693704 1 0.043042863 0.065375336 5909 RAP1 GTPase activating protein "GO:0000139,GO:0003924,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0007411,GO:0016020,GO:0031267,GO:0042803,GO:0043087,GO:0043547,GO:0051056,GO:0090630,GO:1903697" Golgi membrane|GTPase activity|GTPase activator activity|protein binding|cytoplasm|cytosol|signal transduction|axon guidance|membrane|small GTPase binding|protein homodimerization activity|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity|negative regulation of microvillus assembly hsa04015 Rap1 signaling pathway RAP1GAP2 1100.954059 971.3128617 1230.595256 1.266940143 0.341348366 0.325102252 1 5.826550972 7.699873264 23108 RAP1 GTPase activating protein 2 "GO:0005096,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0008361,GO:0031965,GO:0048471,GO:0051056,GO:0090630" GTPase activator activity|protein binding|cytoplasm|centrosome|cytosol|plasma membrane|regulation of cell size|nuclear membrane|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|activation of GTPase activity RAP1GDS1 837.3527741 766.2917561 908.4137921 1.185467265 0.245455825 0.501036712 1 9.966608663 12.3240344 5910 Rap1 GTPase-GDP dissociation stimulator 1 "GO:0005096,GO:0005515,GO:0005739,GO:0005783,GO:0005829,GO:0014829,GO:0031034,GO:0032471,GO:0043547,GO:0051561,GO:0070062" GTPase activator activity|protein binding|mitochondrion|endoplasmic reticulum|cytosol|vascular associated smooth muscle contraction|myosin filament assembly|negative regulation of endoplasmic reticulum calcium ion concentration|positive regulation of GTPase activity|positive regulation of mitochondrial calcium ion concentration|extracellular exosome RAP2A 816.137176 797.7553911 834.5189608 1.046083762 0.064998376 0.862012123 1 7.293049864 7.957773495 5911 "RAP2A, member of RAS oncogene family" "GO:0000287,GO:0001934,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0019003,GO:0030033,GO:0030336,GO:0030496,GO:0031532,GO:0031954,GO:0032486,GO:0034613,GO:0035690,GO:0045184,GO:0045198,GO:0046328,GO:0048814,GO:0055037,GO:0055038,GO:0072659" magnesium ion binding|positive regulation of protein phosphorylation|GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|GDP binding|microvillus assembly|negative regulation of cell migration|midbody|actin cytoskeleton reorganization|positive regulation of protein autophosphorylation|Rap protein signal transduction|cellular protein localization|cellular response to drug|establishment of protein localization|establishment of epithelial cell apical/basal polarity|regulation of JNK cascade|regulation of dendrite morphogenesis|recycling endosome|recycling endosome membrane|protein localization to plasma membrane RAP2B 607.4177422 707.42431 507.4111745 0.717265674 -0.479420505 0.218935261 1 4.264287748 3.190380482 5912 "RAP2B, member of RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0005923,GO:0007165,GO:0016020,GO:0019003,GO:0019904,GO:0030033,GO:0030168,GO:0030336,GO:0031954,GO:0032486,GO:0035579,GO:0043312,GO:0044291,GO:0045121,GO:0055038,GO:0061097,GO:0070062,GO:0070527,GO:0070821,GO:0090557" GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|bicellular tight junction|signal transduction|membrane|GDP binding|protein domain specific binding|microvillus assembly|platelet activation|negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|specific granule membrane|neutrophil degranulation|cell-cell contact zone|membrane raft|recycling endosome membrane|regulation of protein tyrosine kinase activity|extracellular exosome|platelet aggregation|tertiary granule membrane|establishment of endothelial intestinal barrier RAP2C 588.4723101 725.6935174 451.2511028 0.621820496 -0.685429925 0.081393971 1 9.337859899 6.056591966 57826 "RAP2C, member of RAS oncogene family" "GO:0003713,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005829,GO:0005886,GO:0005923,GO:0019003,GO:0030033,GO:0030336,GO:0031954,GO:0032486,GO:0043312,GO:0044291,GO:0045893,GO:0055038,GO:0061097,GO:0070062,GO:0070821,GO:0090557" "transcription coactivator activity|GTPase activity|protein binding|GTP binding|cytoplasm|cytosol|plasma membrane|bicellular tight junction|GDP binding|microvillus assembly|negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|neutrophil degranulation|cell-cell contact zone|positive regulation of transcription, DNA-templated|recycling endosome membrane|regulation of protein tyrosine kinase activity|extracellular exosome|tertiary granule membrane|establishment of endothelial intestinal barrier" hsa04530 Tight junction RAPGEF1 2177.580104 2064.42044 2290.739768 1.109628506 0.150076756 0.640291068 1 9.347006296 10.81847561 2889 Rap guanine nucleotide exchange factor 1 "GO:0000186,GO:0001568,GO:0005085,GO:0005515,GO:0005737,GO:0005769,GO:0005829,GO:0007165,GO:0007169,GO:0007399,GO:0010976,GO:0017124,GO:0019221,GO:0030670,GO:0032486,GO:0032991,GO:0038180,GO:0043231,GO:0043547,GO:0046328,GO:0046579,GO:0046580,GO:0048008,GO:0048471,GO:0051898,GO:0061028,GO:0070373,GO:0070374,GO:0071320,GO:0090090,GO:0090630,GO:0098609,GO:1901888,GO:1905451,GO:1990090,GO:2000178" activation of MAPKK activity|blood vessel development|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|early endosome|cytosol|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|nervous system development|positive regulation of neuron projection development|SH3 domain binding|cytokine-mediated signaling pathway|phagocytic vesicle membrane|Rap protein signal transduction|protein-containing complex|nerve growth factor signaling pathway|intracellular membrane-bounded organelle|positive regulation of GTPase activity|regulation of JNK cascade|positive regulation of Ras protein signal transduction|negative regulation of Ras protein signal transduction|platelet-derived growth factor receptor signaling pathway|perinuclear region of cytoplasm|negative regulation of protein kinase B signaling|establishment of endothelial barrier|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|negative regulation of canonical Wnt signaling pathway|activation of GTPase activity|cell-cell adhesion|regulation of cell junction assembly|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|cellular response to nerve growth factor stimulus|negative regulation of neural precursor cell proliferation "hsa04015,hsa04510,hsa04722,hsa04910,hsa05211" Rap1 signaling pathway|Focal adhesion|Neurotrophin signaling pathway|Insulin signaling pathway|Renal cell carcinoma RAPGEF2 1230.47303 1136.750685 1324.195376 1.164895165 0.220200125 0.518747995 1 5.181102588 6.295423688 9693 Rap guanine nucleotide exchange factor 2 "GO:0000165,GO:0001568,GO:0001764,GO:0005085,GO:0005096,GO:0005509,GO:0005515,GO:0005737,GO:0005770,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0005923,GO:0007186,GO:0007218,GO:0007264,GO:0008285,GO:0010976,GO:0016020,GO:0016324,GO:0019933,GO:0019992,GO:0021591,GO:0021884,GO:0030033,GO:0030139,GO:0030165,GO:0030552,GO:0030553,GO:0031175,GO:0031547,GO:0031697,GO:0032092,GO:0032486,GO:0032991,GO:0035556,GO:0038180,GO:0043005,GO:0043025,GO:0043547,GO:0043950,GO:0045202,GO:0045860,GO:0048022,GO:0048167,GO:0048471,GO:0050699,GO:0050774,GO:0061028,GO:0070300,GO:0070374,GO:0071320,GO:0071321,GO:0071880,GO:0072659,GO:0090557,GO:1901888,GO:1990090,GO:2000481,GO:2000670,GO:2001214,GO:2001224" MAPK cascade|blood vessel development|neuron migration|guanyl-nucleotide exchange factor activity|GTPase activator activity|calcium ion binding|protein binding|cytoplasm|late endosome|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|bicellular tight junction|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|small GTPase mediated signal transduction|negative regulation of cell population proliferation|positive regulation of neuron projection development|membrane|apical plasma membrane|cAMP-mediated signaling|diacylglycerol binding|ventricular system development|forebrain neuron development|microvillus assembly|endocytic vesicle|PDZ domain binding|cAMP binding|cGMP binding|neuron projection development|brain-derived neurotrophic factor receptor signaling pathway|beta-1 adrenergic receptor binding|positive regulation of protein binding|Rap protein signal transduction|protein-containing complex|intracellular signal transduction|nerve growth factor signaling pathway|neuron projection|neuronal cell body|positive regulation of GTPase activity|positive regulation of cAMP-mediated signaling|synapse|positive regulation of protein kinase activity|negative regulation of melanin biosynthetic process|regulation of synaptic plasticity|perinuclear region of cytoplasm|WW domain binding|negative regulation of dendrite morphogenesis|establishment of endothelial barrier|phosphatidic acid binding|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|cellular response to cGMP|adenylate cyclase-activating adrenergic receptor signaling pathway|protein localization to plasma membrane|establishment of endothelial intestinal barrier|regulation of cell junction assembly|cellular response to nerve growth factor stimulus|positive regulation of cAMP-dependent protein kinase activity|positive regulation of dendritic cell apoptotic process|positive regulation of vasculogenesis|positive regulation of neuron migration "hsa04010,hsa04015,hsa04530" MAPK signaling pathway|Rap1 signaling pathway|Tight junction RAPGEF3 27.16627873 38.5683268 15.76423066 0.408735145 -1.290761795 0.207771289 1 0.247510098 0.1055239 10411 Rap guanine nucleotide exchange factor 3 "GO:0001525,GO:0005085,GO:0005515,GO:0005886,GO:0005902,GO:0007165,GO:0012505,GO:0016020,GO:0019904,GO:0019933,GO:0030027,GO:0030175,GO:0030552,GO:0030864,GO:0032486,GO:0033138,GO:0034242,GO:0043547,GO:0045766,GO:0046827,GO:0050796,GO:0051496,GO:0060143,GO:0061028,GO:0070062,GO:0071320,GO:1901985,GO:2000249,GO:2000615" angiogenesis|guanyl-nucleotide exchange factor activity|protein binding|plasma membrane|microvillus|signal transduction|endomembrane system|membrane|protein domain specific binding|cAMP-mediated signaling|lamellipodium|filopodium|cAMP binding|cortical actin cytoskeleton|Rap protein signal transduction|positive regulation of peptidyl-serine phosphorylation|negative regulation of syncytium formation by plasma membrane fusion|positive regulation of GTPase activity|positive regulation of angiogenesis|positive regulation of protein export from nucleus|regulation of insulin secretion|positive regulation of stress fiber assembly|positive regulation of syncytium formation by plasma membrane fusion|establishment of endothelial barrier|extracellular exosome|cellular response to cAMP|positive regulation of protein acetylation|regulation of actin cytoskeleton reorganization|regulation of histone H3-K9 acetylation "hsa04015,hsa04024,hsa04072,hsa04261,hsa04670,hsa04720,hsa04726" Rap1 signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Leukocyte transendothelial migration|Long-term potentiation|Serotonergic synapse RAPGEF4 17.46481393 15.22433953 19.70528833 1.294327961 0.372203218 0.786584994 1 0.129394041 0.174692612 11069 Rap guanine nucleotide exchange factor 4 "GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0007186,GO:0007264,GO:0016020,GO:0017156,GO:0017157,GO:0019933,GO:0030073,GO:0030552,GO:0031267,GO:0050790,GO:0050796,GO:0098686,GO:0098693" guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|membrane|calcium-ion regulated exocytosis|regulation of exocytosis|cAMP-mediated signaling|insulin secretion|cAMP binding|small GTPase binding|regulation of catalytic activity|regulation of insulin secretion|hippocampal mossy fiber to CA3 synapse|regulation of synaptic vesicle cycle "hsa04015,hsa04024,hsa04072,hsa04261,hsa04670,hsa04911" Rap1 signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Leukocyte transendothelial migration|Insulin secretion RAPGEF5 89.84661379 80.1815215 99.51170607 1.241080291 0.311596453 0.666076061 1 0.342230844 0.443031859 9771 Rap guanine nucleotide exchange factor 5 "GO:0005085,GO:0005634,GO:0005654,GO:0007264,GO:0007399,GO:0016604,GO:0030742,GO:0050790" guanyl-nucleotide exchange factor activity|nucleus|nucleoplasm|small GTPase mediated signal transduction|nervous system development|nuclear body|GTP-dependent protein binding|regulation of catalytic activity "hsa04014,hsa04015" Ras signaling pathway|Rap1 signaling pathway RAPGEF6 848.5036817 956.0885222 740.9188412 0.774947951 -0.367828679 0.311294125 1 5.130590249 4.147207788 51735 Rap guanine nucleotide exchange factor 6 "GO:0005085,GO:0005515,GO:0005813,GO:0005829,GO:0005886,GO:0007265,GO:0016324,GO:0030033,GO:0030139,GO:0030742,GO:0031267,GO:0043087,GO:0043547,GO:0070300,GO:0072659,GO:0090557" guanyl-nucleotide exchange factor activity|protein binding|centrosome|cytosol|plasma membrane|Ras protein signal transduction|apical plasma membrane|microvillus assembly|endocytic vesicle|GTP-dependent protein binding|small GTPase binding|regulation of GTPase activity|positive regulation of GTPase activity|phosphatidic acid binding|protein localization to plasma membrane|establishment of endothelial intestinal barrier "hsa04015,hsa04530" Rap1 signaling pathway|Tight junction RAPGEFL1 85.96493922 84.24134538 87.68853307 1.040920378 0.057859718 0.952759768 1 0.707315477 0.76797415 51195 Rap guanine nucleotide exchange factor like 1 "GO:0005085,GO:0007186,GO:0007264,GO:0007399,GO:0016020,GO:0050790" guanyl-nucleotide exchange factor activity|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|nervous system development|membrane|regulation of catalytic activity RAPH1 724.162173 639.4222601 808.902086 1.265051495 0.339196112 0.366090228 1 2.641474855 3.485544364 65059 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 "GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0007165,GO:0016604,GO:0030027,GO:0030175" protein binding|cytosol|cytoskeleton|plasma membrane|signal transduction|nuclear body|lamellipodium|filopodium RARA 542.9774408 646.5269519 439.4279298 0.679674573 -0.557083944 0.164290873 1 5.315634627 3.768530846 5914 retinoic acid receptor alpha "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001972,GO:0003682,GO:0003700,GO:0004879,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006367,GO:0006468,GO:0007165,GO:0008134,GO:0008270,GO:0008284,GO:0009755,GO:0009986,GO:0015629,GO:0019899,GO:0019904,GO:0030154,GO:0030853,GO:0031490,GO:0032526,GO:0032689,GO:0032720,GO:0032736,GO:0032753,GO:0032754,GO:0032991,GO:0043277,GO:0043422,GO:0044323,GO:0045630,GO:0045787,GO:0045892,GO:0045893,GO:0045944,GO:0048384,GO:0051018,GO:0051099,GO:0051393,GO:0071391,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|retinoic acid binding|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|signaling receptor binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|transcription initiation from RNA polymerase II promoter|protein phosphorylation|signal transduction|transcription factor binding|zinc ion binding|positive regulation of cell population proliferation|hormone-mediated signaling pathway|cell surface|actin cytoskeleton|enzyme binding|protein domain specific binding|cell differentiation|negative regulation of granulocyte differentiation|chromatin DNA binding|response to retinoic acid|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|protein-containing complex|apoptotic cell clearance|protein kinase B binding|retinoic acid-responsive element binding|positive regulation of T-helper 2 cell differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|protein kinase A binding|positive regulation of binding|alpha-actinin binding|cellular response to estrogen stimulus|sequence-specific double-stranded DNA binding" "hsa04659,hsa04915,hsa05200,hsa05202,hsa05221" Th17 cell differentiation|Estrogen signaling pathway|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia ThyrH_rcpt RARB 25.92863612 21.31407534 30.54319691 1.433005956 0.519044606 0.633420086 1 0.298199648 0.445729164 5915 retinoic acid receptor beta "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001657,GO:0002068,GO:0003148,GO:0003417,GO:0003677,GO:0004879,GO:0005634,GO:0005654,GO:0005737,GO:0006367,GO:0007165,GO:0008144,GO:0008270,GO:0008285,GO:0009755,GO:0021756,GO:0022008,GO:0030154,GO:0031641,GO:0032331,GO:0035116,GO:0035264,GO:0043065,GO:0043066,GO:0044877,GO:0045666,GO:0045944,GO:0046965,GO:0048048,GO:0048384,GO:0048566,GO:0055012,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|ureteric bud development|glandular epithelial cell development|outflow tract septum morphogenesis|growth plate cartilage development|DNA binding|nuclear receptor activity|nucleus|nucleoplasm|cytoplasm|transcription initiation from RNA polymerase II promoter|signal transduction|drug binding|zinc ion binding|negative regulation of cell population proliferation|hormone-mediated signaling pathway|striatum development|neurogenesis|cell differentiation|regulation of myelination|negative regulation of chondrocyte differentiation|embryonic hindlimb morphogenesis|multicellular organism growth|positive regulation of apoptotic process|negative regulation of apoptotic process|protein-containing complex binding|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|embryonic eye morphogenesis|retinoic acid receptor signaling pathway|embryonic digestive tract development|ventricular cardiac muscle cell differentiation|sequence-specific double-stranded DNA binding" "hsa05200,hsa05222,hsa05223,hsa05226" Pathways in cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer RARG 994.6400199 910.4155036 1078.864536 1.185024345 0.244916698 0.488098701 1 13.36889925 16.52490048 5916 retinoic acid receptor gamma "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001843,GO:0002068,GO:0003430,GO:0003677,GO:0003682,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006367,GO:0008270,GO:0008284,GO:0008285,GO:0008361,GO:0009755,GO:0009952,GO:0016021,GO:0030154,GO:0031076,GO:0031641,GO:0032331,GO:0032526,GO:0035116,GO:0035264,GO:0043065,GO:0043068,GO:0045637,GO:0045944,GO:0046965,GO:0048048,GO:0048384,GO:0060070,GO:0060324,GO:0060534,GO:0060740,GO:0070384,GO:0071300,GO:1990830,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|neural tube closure|glandular epithelial cell development|growth plate cartilage chondrocyte growth|DNA binding|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|transcription initiation from RNA polymerase II promoter|zinc ion binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of cell size|hormone-mediated signaling pathway|anterior/posterior pattern specification|integral component of membrane|cell differentiation|embryonic camera-type eye development|regulation of myelination|negative regulation of chondrocyte differentiation|response to retinoic acid|embryonic hindlimb morphogenesis|multicellular organism growth|positive regulation of apoptotic process|positive regulation of programmed cell death|regulation of myeloid cell differentiation|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|embryonic eye morphogenesis|retinoic acid receptor signaling pathway|canonical Wnt signaling pathway|face development|trachea cartilage development|prostate gland epithelium morphogenesis|Harderian gland development|cellular response to retinoic acid|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" ThyrH_rcpt RARRES1 8.00088154 8.119647747 7.882115332 0.970745971 -0.042834281 1 1 0.221927423 0.224715224 5918 retinoic acid receptor responder 1 "GO:0005515,GO:0005615,GO:0008191,GO:0008285,GO:0010951,GO:0016021,GO:0070062" protein binding|extracellular space|metalloendopeptidase inhibitor activity|negative regulation of cell population proliferation|negative regulation of endopeptidase activity|integral component of membrane|extracellular exosome RARS1 1928.510604 2145.616917 1711.404292 0.797628075 -0.326211904 0.312822482 1 51.21014494 42.60615733 5917 arginyl-tRNA synthetase 1 "GO:0000049,GO:0004814,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006418,GO:0006420,GO:0016020,GO:0017101,GO:0034618,GO:0045296,GO:0070062" tRNA binding|arginine-tRNA ligase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|tRNA aminoacylation for protein translation|arginyl-tRNA aminoacylation|membrane|aminoacyl-tRNA synthetase multienzyme complex|arginine binding|cadherin binding|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis RARS2 586.6989818 503.4181603 669.9798033 1.330861411 0.412360345 0.294367625 1 6.378872621 8.855084143 57038 "arginyl-tRNA synthetase 2, mitochondrial" "GO:0003723,GO:0004814,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006420,GO:0032543" RNA binding|arginine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|arginyl-tRNA aminoacylation|mitochondrial translation hsa00970 Aminoacyl-tRNA biosynthesis RASA1 1219.948121 1326.547451 1113.348791 0.83928305 -0.25277065 0.459197883 1 9.813752351 8.591311713 5921 RAS p21 protein activator 1 "GO:0000165,GO:0000281,GO:0001570,GO:0001726,GO:0001784,GO:0001953,GO:0003924,GO:0005096,GO:0005102,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007162,GO:0007165,GO:0008360,GO:0019870,GO:0030833,GO:0035556,GO:0043066,GO:0043524,GO:0043547,GO:0046580,GO:0048013,GO:0048514,GO:0051020,GO:0051252" MAPK cascade|mitotic cytokinesis|vasculogenesis|ruffle|phosphotyrosine residue binding|negative regulation of cell-matrix adhesion|GTPase activity|GTPase activator activity|signaling receptor binding|protein binding|cytoplasm|cytosol|plasma membrane|negative regulation of cell adhesion|signal transduction|regulation of cell shape|potassium channel inhibitor activity|regulation of actin filament polymerization|intracellular signal transduction|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|ephrin receptor signaling pathway|blood vessel morphogenesis|GTPase binding|regulation of RNA metabolic process "hsa04010,hsa04014,hsa04360" MAPK signaling pathway|Ras signaling pathway|Axon guidance RASA2 383.0152338 353.204677 412.8257905 1.168800464 0.225028657 0.611027332 1 2.433488078 2.966781267 5922 RAS p21 protein activator 2 "GO:0000165,GO:0005096,GO:0005543,GO:0005829,GO:0007165,GO:0043547,GO:0046580,GO:0046872,GO:0048471" MAPK cascade|GTPase activator activity|phospholipid binding|cytosol|signal transduction|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|metal ion binding|perinuclear region of cytoplasm "hsa04010,hsa04014,hsa05203" MAPK signaling pathway|Ras signaling pathway|Viral carcinogenesis RASA3 1749.81229 1682.796996 1816.827584 1.079647509 0.110560368 0.735497246 1 15.96922077 17.98380736 22821 RAS p21 protein activator 3 "GO:0000165,GO:0005096,GO:0005829,GO:0007165,GO:0015278,GO:0031235,GO:0043547,GO:0046580,GO:0046872,GO:0051209" MAPK cascade|GTPase activator activity|cytosol|signal transduction|calcium-release channel activity|intrinsic component of the cytoplasmic side of the plasma membrane|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|metal ion binding|release of sequestered calcium ion into cytosol hsa04014 Ras signaling pathway RASA4 11.01605789 12.17947162 9.852644165 0.808954975 -0.305868687 0.884333199 1 0.104056557 0.087803076 10156 RAS p21 protein activator 4 "GO:0000165,GO:0005096,GO:0005543,GO:0005829,GO:0005886,GO:0034260,GO:0043547,GO:0046580,GO:0046872,GO:0071277" MAPK cascade|GTPase activator activity|phospholipid binding|cytosol|plasma membrane|negative regulation of GTPase activity|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|metal ion binding|cellular response to calcium ion hsa04014 Ras signaling pathway RASA4B 11.94193921 8.119647747 15.76423066 1.941491941 0.957165719 0.487279695 1 0.064074714 0.129759211 100271927 RAS p21 protein activator 4B "GO:0005096,GO:0005543,GO:0005829,GO:0005886,GO:0035556,GO:0043547,GO:0046580,GO:0046872,GO:0071277" GTPase activator activity|phospholipid binding|cytosol|plasma membrane|intracellular signal transduction|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|metal ion binding|cellular response to calcium ion hsa04014 Ras signaling pathway RASAL2 1515.569261 1363.085866 1668.052657 1.223732634 0.291288387 0.379205386 1 4.359402021 5.564541592 9462 RAS protein activator like 2 "GO:0000165,GO:0005096,GO:0005515,GO:0005829,GO:0007165,GO:0043547" MAPK cascade|GTPase activator activity|protein binding|cytosol|signal transduction|positive regulation of GTPase activity hsa04014 Ras signaling pathway RASD1 34.0334381 36.53841486 31.52846133 0.862885307 -0.212759283 0.850250849 1 1.058662364 0.952854256 51655 ras related dexamethasone induced 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005886,GO:0007165,GO:0007186,GO:0007263,GO:0016529,GO:0045892,GO:0048471" "GTPase activity|protein binding|GTP binding|nucleus|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|nitric oxide mediated signal transduction|sarcoplasmic reticulum|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm" "hsa04713,hsa04934" Circadian entrainment|Cushing syndrome RASD2 39.81141261 27.40381115 52.21901408 1.905538387 0.930198671 0.309438388 1 0.172367904 0.342602108 23551 RASD family member 2 "GO:0003924,GO:0005525,GO:0005886,GO:0007165,GO:0007626,GO:0031397,GO:0031624,GO:0031681,GO:0033235,GO:0043548,GO:0043949,GO:0051897" GTPase activity|GTP binding|plasma membrane|signal transduction|locomotory behavior|negative regulation of protein ubiquitination|ubiquitin conjugating enzyme binding|G-protein beta-subunit binding|positive regulation of protein sumoylation|phosphatidylinositol 3-kinase binding|regulation of cAMP-mediated signaling|positive regulation of protein kinase B signaling RASEF 55.88740457 48.71788648 63.05692266 1.294327961 0.372203218 0.661482376 1 0.364782538 0.492486469 158158 RAS and EF-hand domain containing "GO:0003924,GO:0005509,GO:0005525,GO:0005829,GO:0019003,GO:0042802,GO:0048471" GTPase activity|calcium ion binding|GTP binding|cytosol|GDP binding|identical protein binding|perinuclear region of cytoplasm RASGRF1 104.2341467 120.7797602 87.68853307 0.726020096 -0.461918614 0.493585269 1 0.60691227 0.459611079 5923 Ras protein specific guanine nucleotide releasing factor 1 "GO:0000165,GO:0005085,GO:0005829,GO:0005886,GO:0007165,GO:0007264,GO:0007616,GO:0008283,GO:0030426,GO:0031175,GO:0034976,GO:0035020,GO:0035023,GO:0035254,GO:0043005,GO:0043547,GO:0046578,GO:0046579,GO:0048167,GO:0048168,GO:0090630,GO:2000310" MAPK cascade|guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|signal transduction|small GTPase mediated signal transduction|long-term memory|cell population proliferation|growth cone|neuron projection development|response to endoplasmic reticulum stress|regulation of Rac protein signal transduction|regulation of Rho protein signal transduction|glutamate receptor binding|neuron projection|positive regulation of GTPase activity|regulation of Ras protein signal transduction|positive regulation of Ras protein signal transduction|regulation of synaptic plasticity|regulation of neuronal synaptic plasticity|activation of GTPase activity|regulation of NMDA receptor activity "hsa04010,hsa04014,hsa04510" MAPK signaling pathway|Ras signaling pathway|Focal adhesion RASGRF2 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.011270322 0.022823795 5924 Ras protein specific guanine nucleotide releasing factor 2 "GO:0000165,GO:0005085,GO:0005516,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0007186,GO:0007264,GO:0034976,GO:0035023,GO:0043065,GO:0050790,GO:0051056,GO:0060291,GO:2000310" MAPK cascade|guanyl-nucleotide exchange factor activity|calmodulin binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|response to endoplasmic reticulum stress|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|long-term synaptic potentiation|regulation of NMDA receptor activity "hsa04010,hsa04014" MAPK signaling pathway|Ras signaling pathway RASGRP2 18.01682924 19.2841634 16.74949508 0.868562184 -0.203298953 0.907139997 1 0.318135129 0.288222893 10235 RAS guanyl releasing protein 2 "GO:0001558,GO:0005085,GO:0005509,GO:0005829,GO:0005886,GO:0007165,GO:0007265,GO:0008289,GO:0019992,GO:0032587,GO:0043005,GO:0043547,GO:0045202,GO:0071277" regulation of cell growth|guanyl-nucleotide exchange factor activity|calcium ion binding|cytosol|plasma membrane|signal transduction|Ras protein signal transduction|lipid binding|diacylglycerol binding|ruffle membrane|neuron projection|positive regulation of GTPase activity|synapse|cellular response to calcium ion "hsa04010,hsa04014,hsa04015,hsa04062,hsa04611,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Platelet activation|Pathways in cancer RASGRP3 5.030242514 7.104691779 2.95579325 0.416033987 -1.265226703 0.543955984 1 0.064903964 0.028165402 25780 RAS guanyl releasing protein 3 "GO:0000165,GO:0005085,GO:0005096,GO:0005509,GO:0005515,GO:0005886,GO:0005887,GO:0007264,GO:0007265,GO:0019900,GO:0019992,GO:0031267,GO:0032045,GO:0043547,GO:0048471" MAPK cascade|guanyl-nucleotide exchange factor activity|GTPase activator activity|calcium ion binding|protein binding|plasma membrane|integral component of plasma membrane|small GTPase mediated signal transduction|Ras protein signal transduction|kinase binding|diacylglycerol binding|small GTPase binding|guanyl-nucleotide exchange factor complex|positive regulation of GTPase activity|perinuclear region of cytoplasm "hsa04010,hsa04014,hsa04015,hsa04662,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|B cell receptor signaling pathway|Pathways in cancer RASIP1 24.3913564 17.25425146 31.52846133 1.827286533 0.869702877 0.415654023 1 0.273168793 0.520659343 54922 Ras interacting protein 1 "GO:0001525,GO:0001570,GO:0005515,GO:0005795,GO:0005911,GO:0007165,GO:0010507,GO:0032991,GO:0033625,GO:0035024,GO:0042803,GO:0043087,GO:0048471,GO:0048754,GO:0051020,GO:1905709,GO:2000299" angiogenesis|vasculogenesis|protein binding|Golgi stack|cell-cell junction|signal transduction|negative regulation of autophagy|protein-containing complex|positive regulation of integrin activation|negative regulation of Rho protein signal transduction|protein homodimerization activity|regulation of GTPase activity|perinuclear region of cytoplasm|branching morphogenesis of an epithelial tube|GTPase binding|negative regulation of membrane permeability|negative regulation of Rho-dependent protein serine/threonine kinase activity RASL10A 5.493183171 5.074779842 5.911586499 1.164895165 0.220200125 1 1 0.094423107 0.114731074 10633 RAS like family 10 member A "GO:0003924,GO:0005525,GO:0005730,GO:0005886,GO:0007264" GTPase activity|GTP binding|nucleolus|plasma membrane|small GTPase mediated signal transduction RASL10B 24.8839886 17.25425146 32.51372575 1.884389237 0.914096997 0.388210594 1 0.201910113 0.39686666 91608 RAS like family 10 member B "GO:0003050,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0007165,GO:0090277" regulation of systemic arterial blood pressure by atrial natriuretic peptide|GTPase activity|protein binding|GTP binding|plasma membrane|signal transduction|positive regulation of peptide hormone secretion RASL11A 13.59798514 20.29911937 6.896850916 0.33976109 -1.557407454 0.224386303 1 0.397401927 0.140837899 387496 RAS like family 11 member A "GO:0003924,GO:0005515,GO:0005525,GO:0005730,GO:0007165,GO:0016020,GO:0045943" GTPase activity|protein binding|GTP binding|nucleolus|signal transduction|membrane|positive regulation of transcription by RNA polymerase I RASL11B 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.104479551 0.079344 65997 RAS like family 11 member B "GO:0003924,GO:0005160,GO:0005515,GO:0005525,GO:0007165,GO:0016020,GO:0030512" GTPase activity|transforming growth factor beta receptor binding|protein binding|GTP binding|signal transduction|membrane|negative regulation of transforming growth factor beta receptor signaling pathway RASSF1 776.1030767 755.1272405 797.078913 1.055555766 0.0780028 0.835815371 1 14.52507816 15.99247168 11186 Ras association domain family member 1 "GO:0000922,GO:0005515,GO:0005634,GO:0005737,GO:0005815,GO:0005874,GO:0007050,GO:0007165,GO:0007265,GO:0008270,GO:0015630,GO:0070507" spindle pole|protein binding|nucleus|cytoplasm|microtubule organizing center|microtubule|cell cycle arrest|signal transduction|Ras protein signal transduction|zinc ion binding|microtubule cytoskeleton|regulation of microtubule cytoskeleton organization "hsa04014,hsa04390,hsa04392,hsa05200,hsa05206,hsa05219,hsa05223" Ras signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species|Pathways in cancer|MicroRNAs in cancer|Bladder cancer|Non-small cell lung cancer RASSF10 3.044867905 6.08973581 0 0 #NAME? 0.124110187 1 0.109994164 0 644943 Ras association domain family member 10 "GO:0000922,GO:0005515,GO:0005815,GO:0005829,GO:0007165,GO:0050769,GO:2000179" spindle pole|protein binding|microtubule organizing center|cytosol|signal transduction|positive regulation of neurogenesis|positive regulation of neural precursor cell proliferation RASSF2 701.424141 667.8410272 735.0072547 1.100572179 0.138253765 0.716575012 1 5.853892701 6.720153881 9770 Ras association domain family member 2 "GO:0000776,GO:0000777,GO:0001501,GO:0001503,GO:0004672,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006468,GO:0007049,GO:0007165,GO:0031954,GO:0032991,GO:0033137,GO:0038168,GO:0043065,GO:0045667,GO:0045670,GO:0045860,GO:0046330,GO:0046849,GO:0048872,GO:0050821,GO:1901222,GO:1901223" kinetochore|condensed chromosome kinetochore|skeletal system development|ossification|protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|protein phosphorylation|cell cycle|signal transduction|positive regulation of protein autophosphorylation|protein-containing complex|negative regulation of peptidyl-serine phosphorylation|epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade|positive regulation of apoptotic process|regulation of osteoblast differentiation|regulation of osteoclast differentiation|positive regulation of protein kinase activity|positive regulation of JNK cascade|bone remodeling|homeostasis of number of cells|protein stabilization|regulation of NIK/NF-kappaB signaling|negative regulation of NIK/NF-kappaB signaling hsa04392 Hippo signaling pathway - multiple species RASSF3 792.6662577 843.4284097 741.9041057 0.87962902 -0.185032893 0.616636923 1 11.41851738 10.47671659 283349 Ras association domain family member 3 "GO:0005515,GO:0005737,GO:0005829,GO:0005874,GO:0005886,GO:0007165,GO:0042802,GO:0042981" protein binding|cytoplasm|cytosol|microtubule|plasma membrane|signal transduction|identical protein binding|regulation of apoptotic process RASSF4 221.2591633 274.0381115 168.4802152 0.614805781 -0.701797363 0.178893196 1 5.227519246 3.352351222 83937 Ras association domain family member 4 "GO:0005515,GO:0007049,GO:0007165" protein binding|cell cycle|signal transduction hsa04392 Hippo signaling pathway - multiple species RASSF5 39.09337216 45.67301858 32.51372575 0.711880378 -0.490293258 0.603947233 1 0.534344483 0.396774983 83593 Ras association domain family member 5 "GO:0005515,GO:0005634,GO:0005737,GO:0005874,GO:0006915,GO:0007165,GO:0008285,GO:0031398,GO:0035556,GO:0042981,GO:0046872,GO:1900180" protein binding|nucleus|cytoplasm|microtubule|apoptotic process|signal transduction|negative regulation of cell population proliferation|positive regulation of protein ubiquitination|intracellular signal transduction|regulation of apoptotic process|metal ion binding|regulation of protein localization to nucleus "hsa04014,hsa04015,hsa04218,hsa04670,hsa05200,hsa05223" Ras signaling pathway|Rap1 signaling pathway|Cellular senescence|Leukocyte transendothelial migration|Pathways in cancer|Non-small cell lung cancer RASSF6 8.97130018 7.104691779 10.83790858 1.525457954 0.609242415 0.728176322 1 0.025368554 0.040365644 166824 Ras association domain family member 6 "GO:0005515,GO:0006915,GO:0007165,GO:0042981" protein binding|apoptotic process|signal transduction|regulation of apoptotic process "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species RASSF7 703.3852672 599.8389773 806.9315572 1.345246954 0.42787104 0.256988585 1 17.56053647 24.64085236 8045 Ras association domain family member 7 "GO:0005515,GO:0005737,GO:0006915,GO:0007165,GO:0034451,GO:0070507" protein binding|cytoplasm|apoptotic process|signal transduction|centriolar satellite|regulation of microtubule cytoskeleton organization RASSF8 1848.657174 1805.606668 1891.70768 1.047685364 0.067205519 0.837167815 1 11.47685842 12.54208764 11228 Ras association domain family member 8 GO:0007165 signal transduction RASSF9 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.026501429 0.035779112 9182 Ras association domain family member 9 "GO:0005515,GO:0005768,GO:0005829,GO:0006605,GO:0007165,GO:0012510,GO:0016197,GO:0046907,GO:0055037,GO:0070062" protein binding|endosome|cytosol|protein targeting|signal transduction|trans-Golgi network transport vesicle membrane|endosomal transport|intracellular transport|recycling endosome|extracellular exosome RAVER1 1354.361001 1523.448909 1185.273093 0.778019589 -0.362121616 0.281296537 1 22.14618623 17.9723724 125950 "ribonucleoprotein, PTB binding 1" "GO:0000398,GO:0003676,GO:0003723,GO:0005515,GO:0005634,GO:0005737" "mRNA splicing, via spliceosome|nucleic acid binding|RNA binding|protein binding|nucleus|cytoplasm" RAVER2 456.9585617 491.2386887 422.6784347 0.860433928 -0.216863681 0.60632429 1 5.507971352 4.9433929 55225 "ribonucleoprotein, PTB binding 2" "GO:0000398,GO:0003676,GO:0003723,GO:0005634,GO:0005737" "mRNA splicing, via spliceosome|nucleic acid binding|RNA binding|nucleus|cytoplasm" RB1 1682.4783 1592.465914 1772.490685 1.113047802 0.154515553 0.637534211 1 16.88002944 19.59760256 5925 RB transcriptional corepressor 1 "GO:0000082,GO:0000122,GO:0000785,GO:0000977,GO:0001102,GO:0001894,GO:0003180,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005819,GO:0006338,GO:0006355,GO:0006469,GO:0007050,GO:0007265,GO:0007346,GO:0008024,GO:0008134,GO:0010629,GO:0016032,GO:0016514,GO:0016605,GO:0019900,GO:0030154,GO:0030308,GO:0031134,GO:0031175,GO:0031625,GO:0034088,GO:0034349,GO:0035189,GO:0035914,GO:0042551,GO:0042802,GO:0043353,GO:0043433,GO:0043550,GO:0045445,GO:0045651,GO:0045786,GO:0045842,GO:0045879,GO:0045892,GO:0045944,GO:0048565,GO:0048667,GO:0050680,GO:0050728,GO:0051146,GO:0051219,GO:0051301,GO:0051402,GO:0061676,GO:0071459,GO:0071466,GO:0071901,GO:0071922,GO:0071930,GO:0090230,GO:0097284,GO:0097718,GO:0120163,GO:1902948,GO:1903055,GO:1904028,GO:1904761,GO:2000134,GO:2000679,GO:2001234" "G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|tissue homeostasis|aortic valve morphogenesis|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|spindle|chromatin remodeling|regulation of transcription, DNA-templated|negative regulation of protein kinase activity|cell cycle arrest|Ras protein signal transduction|regulation of mitotic cell cycle|cyclin/CDK positive transcription elongation factor complex|transcription factor binding|negative regulation of gene expression|viral process|SWI/SNF complex|PML body|kinase binding|cell differentiation|negative regulation of cell growth|sister chromatid biorientation|neuron projection development|ubiquitin protein ligase binding|maintenance of mitotic sister chromatid cohesion|glial cell apoptotic process|Rb-E2F complex|skeletal muscle cell differentiation|neuron maturation|identical protein binding|enucleate erythrocyte differentiation|negative regulation of DNA-binding transcription factor activity|regulation of lipid kinase activity|myoblast differentiation|positive regulation of macrophage differentiation|negative regulation of cell cycle|positive regulation of mitotic metaphase/anaphase transition|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|digestive tract development|cell morphogenesis involved in neuron differentiation|negative regulation of epithelial cell proliferation|negative regulation of inflammatory response|striated muscle cell differentiation|phosphoprotein binding|cell division|neuron apoptotic process|importin-alpha family protein binding|protein localization to chromosome, centromeric region|cellular response to xenobiotic stimulus|negative regulation of protein serine/threonine kinase activity|regulation of cohesin loading|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|regulation of centromere complex assembly|hepatocyte apoptotic process|disordered domain specific binding|negative regulation of cold-induced thermogenesis|negative regulation of tau-protein kinase activity|positive regulation of extracellular matrix organization|positive regulation of collagen fibril organization|negative regulation of myofibroblast differentiation|negative regulation of G1/S transition of mitotic cell cycle|positive regulation of transcription regulatory region DNA binding|negative regulation of apoptotic signaling pathway" "hsa01522,hsa04110,hsa04218,hsa04934,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05203,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Endocrine resistance|Cell cycle|Cellular senescence|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer chromosome_remodelling_factor RB1CC1 3520.5732 2945.40222 4095.74418 1.390555134 0.475660947 0.135352309 1 13.31793873 19.31706562 9821 RB1 inducible coiled-coil 1 "GO:0000045,GO:0000407,GO:0000421,GO:0000422,GO:0001889,GO:0001934,GO:0005515,GO:0005764,GO:0005789,GO:0005829,GO:0006914,GO:0007049,GO:0007507,GO:0016236,GO:0016241,GO:0019898,GO:0019901,GO:0030242,GO:0031965,GO:0034045,GO:0034727,GO:0045793,GO:0046330,GO:0060090,GO:0061709,GO:0061723,GO:1990316,GO:2001237" autophagosome assembly|phagophore assembly site|autophagosome membrane|autophagy of mitochondrion|liver development|positive regulation of protein phosphorylation|protein binding|lysosome|endoplasmic reticulum membrane|cytosol|autophagy|cell cycle|heart development|macroautophagy|regulation of macroautophagy|extrinsic component of membrane|protein kinase binding|autophagy of peroxisome|nuclear membrane|phagophore assembly site membrane|piecemeal microautophagy of the nucleus|positive regulation of cell size|positive regulation of JNK cascade|molecular adaptor activity|reticulophagy|glycophagy|Atg1/ULK1 kinase complex|negative regulation of extrinsic apoptotic signaling pathway "hsa04140,hsa04211,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - animal|Longevity regulating pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases RBAK 504.0528154 545.031355 463.0742758 0.849628689 -0.235095613 0.566057289 1 4.370474252 3.873233366 57786 RB associated KRAB zinc finger "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0008270,GO:0045892" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|negative regulation of transcription, DNA-templated" hsa05168 Herpes simplex virus 1 infection RBAK-RBAKDN 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.125835837 0.254833115 100533952 RBAK-RBAKDN readthrough RBBP4 2583.039176 2335.413683 2830.664669 1.212061353 0.277462728 0.384291956 1 14.8593548 18.78626681 5928 "RB binding protein 4, chromatin remodeling factor" "GO:0000785,GO:0000978,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006335,GO:0006336,GO:0006338,GO:0007049,GO:0008094,GO:0008285,GO:0016580,GO:0016581,GO:0016589,GO:0031492,GO:0031497,GO:0032991,GO:0033186,GO:0034080,GO:0035098,GO:0042393,GO:0042826,GO:0043044,GO:0045814,GO:0051726,GO:0060416,GO:0070317,GO:1901796" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA replication|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|chromatin remodeling|cell cycle|DNA-dependent ATPase activity|negative regulation of cell population proliferation|Sin3 complex|NuRD complex|NURF complex|nucleosomal DNA binding|chromatin assembly|protein-containing complex|CAF-1 complex|CENP-A containing nucleosome assembly|ESC/E(Z) complex|histone binding|histone deacetylase binding|ATP-dependent chromatin remodeling|negative regulation of gene expression, epigenetic|regulation of cell cycle|response to growth hormone|negative regulation of G0 to G1 transition|regulation of signal transduction by p53 class mediator" hsa04218 Cellular senescence RBBP5 842.1967025 861.6976171 822.6957878 0.954738381 -0.066822637 0.857099559 1 9.909614991 9.868635149 5929 "RB binding protein 5, histone lysine methyltransferase complex subunit" "GO:0000976,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006974,GO:0035064,GO:0035097,GO:0042800,GO:0043627,GO:0043687,GO:0044666,GO:0045652,GO:0048188,GO:0051568,GO:0071339,GO:1904837" transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cellular response to DNA damage stimulus|methylated histone binding|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|response to estrogen|post-translational protein modification|MLL3/4 complex|regulation of megakaryocyte differentiation|Set1C/COMPASS complex|histone H3-K4 methylation|MLL1 complex|beta-catenin-TCF complex assembly hsa04934 Cushing syndrome other RBBP6 1151.624907 1101.227226 1202.022588 1.091530031 0.126351824 0.715107065 1 7.663269316 8.725005458 5930 "RB binding protein 6, ubiquitin ligase" "GO:0000209,GO:0001701,GO:0003723,GO:0004842,GO:0005515,GO:0005694,GO:0005730,GO:0005813,GO:0005829,GO:0006260,GO:0006275,GO:0006397,GO:0006511,GO:0006974,GO:0008270,GO:0016607,GO:0019901,GO:0032991,GO:0035264,GO:0048568,GO:0061053,GO:0061630" protein polyubiquitination|in utero embryonic development|RNA binding|ubiquitin-protein transferase activity|protein binding|chromosome|nucleolus|centrosome|cytosol|DNA replication|regulation of DNA replication|mRNA processing|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|zinc ion binding|nuclear speck|protein kinase binding|protein-containing complex|multicellular organism growth|embryonic organ development|somite development|ubiquitin protein ligase activity RBBP7 4630.097477 4266.874891 4993.320063 1.170252278 0.226819574 0.478654647 1 81.51722392 99.50497762 5931 "RB binding protein 7, chromatin remodeling factor" "GO:0000122,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0016581,GO:0030308,GO:0034080,GO:0035098,GO:0043687,GO:0045814,GO:0048545,GO:0070317,GO:0070370,GO:1901796" "negative regulation of transcription by RNA polymerase II|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA replication|NuRD complex|negative regulation of cell growth|CENP-A containing nucleosome assembly|ESC/E(Z) complex|post-translational protein modification|negative regulation of gene expression, epigenetic|response to steroid hormone|negative regulation of G0 to G1 transition|cellular heat acclimation|regulation of signal transduction by p53 class mediator" RBBP8 881.6127224 794.7105232 968.5149215 1.218701519 0.285344828 0.429160084 1 9.955301615 12.65516187 5932 "RB binding protein 8, endonuclease" "GO:0000014,GO:0000403,GO:0000406,GO:0000724,GO:0000729,GO:0001103,GO:0003684,GO:0003690,GO:0003697,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0006357,GO:0010792,GO:0017053,GO:0035861,GO:0042802,GO:0043231,GO:0045892,GO:0051301,GO:0051321,GO:0070317,GO:0070336,GO:0090305,GO:1901796" "single-stranded DNA endodeoxyribonuclease activity|Y-form DNA binding|double-strand/single-strand DNA junction binding|double-strand break repair via homologous recombination|DNA double-strand break processing|RNA polymerase II repressing transcription factor binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|DNA replication|DNA repair|regulation of transcription by RNA polymerase II|DNA double-strand break processing involved in repair via single-strand annealing|transcription repressor complex|site of double-strand break|identical protein binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|cell division|meiotic cell cycle|negative regulation of G0 to G1 transition|flap-structured DNA binding|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator" hsa03440 Homologous recombination RBBP9 1165.712803 1155.019892 1176.405713 1.018515544 0.026467998 0.941196653 1 15.22187949 16.17155828 10741 "RB binding protein 9, serine hydrolase" "GO:0005515,GO:0005654,GO:0016787,GO:0042127" protein binding|nucleoplasm|hydrolase activity|regulation of cell population proliferation RBCK1 2059.951854 1802.5618 2317.341908 1.285582501 0.362422197 0.259952405 1 23.79911264 31.91366242 10616 RANBP2-type and C3HC4-type zinc finger containing 1 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0007249,GO:0010803,GO:0016032,GO:0032088,GO:0042802,GO:0043123,GO:0043130,GO:0043161,GO:0046872,GO:0050852,GO:0051092,GO:0060546,GO:0071797,GO:0097039,GO:1901224,GO:2001238" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|I-kappaB kinase/NF-kappaB signaling|regulation of tumor necrosis factor-mediated signaling pathway|viral process|negative regulation of NF-kappaB transcription factor activity|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|negative regulation of necroptotic process|LUBAC complex|protein linear polyubiquitination|positive regulation of NIK/NF-kappaB signaling|positive regulation of extrinsic apoptotic signaling pathway "hsa04217,hsa04621,hsa05131" Necroptosis|NOD-like receptor signaling pathway|Shigellosis other RBFA 491.2052839 474.9993932 507.4111745 1.068235416 0.095229621 0.820638959 1 4.303585611 4.795273132 79863 ribosome binding factor A "GO:0003674,GO:0005515,GO:0005575,GO:0005739,GO:0006364,GO:0008150" molecular_function|protein binding|cellular_component|mitochondrion|rRNA processing|biological_process RBFOX2 4442.939054 4303.413306 4582.464801 1.064844224 0.090642394 0.777145499 1 22.65620607 25.16455155 23543 RNA binding fox-1 homolog 2 "GO:0000381,GO:0003714,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0007399,GO:0008134,GO:0008380,GO:0008543,GO:0010724,GO:0016070,GO:0021942,GO:0030520,GO:0042127,GO:0045892,GO:0048813,GO:0050885" "regulation of alternative mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|nervous system development|transcription factor binding|RNA splicing|fibroblast growth factor receptor signaling pathway|regulation of definitive erythrocyte differentiation|RNA metabolic process|radial glia guided migration of Purkinje cell|intracellular estrogen receptor signaling pathway|regulation of cell population proliferation|negative regulation of transcription, DNA-templated|dendrite morphogenesis|neuromuscular process controlling balance" RBIS 1286.008096 1296.098772 1275.917419 0.984429156 -0.022640708 0.949096389 1 38.16443629 39.18855494 401466 ribosomal biogenesis factor "GO:0005654,GO:0005730,GO:0005829,GO:0042254" nucleoplasm|nucleolus|cytosol|ribosome biogenesis RBKS 58.30330668 79.16656553 37.44004783 0.472927524 -1.080308987 0.183045758 1 1.69463536 0.835962477 64080 ribokinase "GO:0004747,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006098,GO:0019303,GO:0042802,GO:0046835,GO:0046872" ribokinase activity|protein binding|ATP binding|nucleus|cytosol|pentose-phosphate shunt|D-ribose catabolic process|identical protein binding|carbohydrate phosphorylation|metal ion binding hsa00030 Pentose phosphate pathway RBL1 1350.649557 1269.709916 1431.589197 1.127493122 0.173118632 0.607420948 1 10.35862242 12.18237135 5933 RB transcriptional corepressor like 1 "GO:0000122,GO:0000785,GO:0000977,GO:0001102,GO:0005515,GO:0005654,GO:0005667,GO:0006325,GO:0007049,GO:0008134,GO:0010629,GO:0016032,GO:0030154,GO:0043550,GO:0045944,GO:0051302,GO:1990841,GO:2000134,GO:2000773" negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|protein binding|nucleoplasm|transcription regulator complex|chromatin organization|cell cycle|transcription factor binding|negative regulation of gene expression|viral process|cell differentiation|regulation of lipid kinase activity|positive regulation of transcription by RNA polymerase II|regulation of cell division|promoter-specific chromatin binding|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of cellular senescence "hsa04110,hsa04218,hsa04350,hsa05165,hsa05203" Cell cycle|Cellular senescence|TGF-beta signaling pathway|Human papillomavirus infection|Viral carcinogenesis other RBL2 1597.17078 1317.412847 1876.928714 1.424708069 0.510666333 0.121047545 1 12.41345361 18.44736918 5934 RB transcriptional corepressor like 2 "GO:0000785,GO:0000977,GO:0001102,GO:0005515,GO:0005654,GO:0005667,GO:0005694,GO:0005730,GO:0005829,GO:0006325,GO:0006357,GO:0006977,GO:0010629,GO:0030154,GO:0043550,GO:0051302,GO:0070062,GO:1990841,GO:2000134" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|protein binding|nucleoplasm|transcription regulator complex|chromosome|nucleolus|cytosol|chromatin organization|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of gene expression|cell differentiation|regulation of lipid kinase activity|regulation of cell division|extracellular exosome|promoter-specific chromatin binding|negative regulation of G1/S transition of mitotic cell cycle" "hsa04068,hsa04110,hsa04151,hsa04218,hsa05165,hsa05203" FoxO signaling pathway|Cell cycle|PI3K-Akt signaling pathway|Cellular senescence|Human papillomavirus infection|Viral carcinogenesis other RBM10 1906.154603 2065.435396 1746.873811 0.845765408 -0.24167054 0.455169941 1 27.57169646 24.32368312 8241 RNA binding motif protein 10 "GO:0000122,GO:0000381,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0008150,GO:0008285,GO:0016607,GO:0032991,GO:0034393,GO:0035198,GO:0042802,GO:0046872,GO:0048025,GO:0070935" "negative regulation of transcription by RNA polymerase II|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|biological_process|negative regulation of cell population proliferation|nuclear speck|protein-containing complex|positive regulation of smooth muscle cell apoptotic process|miRNA binding|identical protein binding|metal ion binding|negative regulation of mRNA splicing, via spliceosome|3'-UTR-mediated mRNA stabilization" RBM11 8.463822196 6.08973581 10.83790858 1.779700946 0.831634837 0.617753532 1 0.166445567 0.308983433 54033 RNA binding motif protein 11 "GO:0000381,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0007275,GO:0008266,GO:0008380,GO:0016607,GO:0030154,GO:0034599,GO:0042803" "regulation of alternative mRNA splicing, via spliceosome|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|multicellular organism development|poly(U) RNA binding|RNA splicing|nuclear speck|cell differentiation|cellular response to oxidative stress|protein homodimerization activity" RBM12 2491.689925 2927.133013 2056.246837 0.7024781 -0.509474845 0.110763353 1 22.30649425 16.34481615 10137 RNA binding motif protein 12 "GO:0003723,GO:0005515,GO:0005654,GO:0043484,GO:1990904" RNA binding|protein binding|nucleoplasm|regulation of RNA splicing|ribonucleoprotein complex RBM12B 1346.63427 1264.635137 1428.633404 1.129680303 0.175914551 0.601754268 1 7.373006596 8.687925909 389677 RNA binding motif protein 12B "GO:0003723,GO:0005515,GO:0005654,GO:0043484,GO:1990904" RNA binding|protein binding|nucleoplasm|regulation of RNA splicing|ribonucleoprotein complex RBM14 662.1417331 743.9627248 580.3207413 0.780040077 -0.358379846 0.348894237 1 9.389256783 7.639484656 10432 RNA binding motif protein 14 "GO:0000398,GO:0002218,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0009725,GO:0016575,GO:0016607,GO:0030374,GO:0045087,GO:0045944,GO:0046600,GO:0060395,GO:0098534,GO:1990904" "mRNA splicing, via spliceosome|activation of innate immune response|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|response to hormone|histone deacetylation|nuclear speck|nuclear receptor coactivator activity|innate immune response|positive regulation of transcription by RNA polymerase II|negative regulation of centriole replication|SMAD protein signal transduction|centriole assembly|ribonucleoprotein complex" RBM15 424.8686825 419.1768149 430.56055 1.027157359 0.038657217 0.933487792 1 6.294048891 6.743463694 64783 RNA binding motif protein 15 "GO:0000381,GO:0000398,GO:0001510,GO:0001569,GO:0003676,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0007221,GO:0009048,GO:0016032,GO:0016607,GO:0031965,GO:0036396,GO:0038163,GO:0045638,GO:0045652,GO:0045892,GO:0048536,GO:0060412,GO:0060674" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA methylation|branching involved in blood vessel morphogenesis|nucleic acid binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|positive regulation of transcription of Notch receptor target|dosage compensation by inactivation of X chromosome|viral process|nuclear speck|nuclear membrane|RNA N6-methyladenosine methyltransferase complex|thrombopoietin-mediated signaling pathway|negative regulation of myeloid cell differentiation|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|spleen development|ventricular septum morphogenesis|placenta blood vessel development" RBM15B 2426.823548 2230.873218 2622.773877 1.175671417 0.233484904 0.464818674 1 17.05704385 20.91730145 29890 RNA binding motif protein 15B "GO:0000381,GO:0000398,GO:0001510,GO:0003676,GO:0003723,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005730,GO:0006406,GO:0006913,GO:0009048,GO:0016032,GO:0016607,GO:0036396,GO:0045892" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA methylation|nucleic acid binding|RNA binding|protein binding|nucleus|nuclear envelope|nucleoplasm|nucleolus|mRNA export from nucleus|nucleocytoplasmic transport|dosage compensation by inactivation of X chromosome|viral process|nuclear speck|RNA N6-methyladenosine methyltransferase complex|negative regulation of transcription, DNA-templated" RBM17 1387.779081 1416.878532 1358.67963 0.958924565 -0.060510766 0.858491896 1 18.39525742 18.39950942 84991 RNA binding motif protein 17 "GO:0000380,GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005681" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|spliceosomal complex" hsa03040 Spliceosome RBM18 553.3133146 578.524902 528.1017273 0.912841825 -0.1315632 0.744397589 1 5.910882665 5.628125832 92400 RNA binding motif protein 18 "GO:0003723,GO:0005654,GO:0005829,GO:0045171" RNA binding|nucleoplasm|cytosol|intercellular bridge RBM19 866.6325962 881.9967365 851.2684559 0.965160551 -0.051159146 0.890537898 1 7.97963973 8.033388611 9904 RNA binding motif protein 19 "GO:0000398,GO:0003723,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0007275,GO:0016020,GO:0016607,GO:0040019" "mRNA splicing, via spliceosome|RNA binding|nucleoplasm|chromosome|nucleolus|cytoplasm|multicellular organism development|membrane|nuclear speck|positive regulation of embryonic development" RBM20 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.020513983 0.004154335 282996 RNA binding motif protein 20 "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0006397,GO:0006417,GO:0007507,GO:0008270,GO:0008380,GO:0033120,GO:0043484" RNA binding|mRNA binding|protein binding|nucleus|mRNA processing|regulation of translation|heart development|zinc ion binding|RNA splicing|positive regulation of RNA splicing|regulation of RNA splicing RBM22 1185.77439 1179.378835 1192.169944 1.010845632 0.015562698 0.966456955 1 25.98146038 27.39455985 55696 RNA binding motif protein 22 "GO:0000398,GO:0000974,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0017070,GO:0033120,GO:0035690,GO:0036002,GO:0042307,GO:0045292,GO:0046827,GO:0046872,GO:0048306,GO:0071006,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|Prp19 complex|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|U6 snRNA binding|positive regulation of RNA splicing|cellular response to drug|pre-mRNA binding|positive regulation of protein import into nucleus|mRNA cis splicing, via spliceosome|positive regulation of protein export from nucleus|metal ion binding|calcium-dependent protein binding|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome RBM23 2148.174589 2209.559143 2086.790034 0.944437283 -0.082473099 0.798176839 1 8.89840774 8.765997752 55147 RNA binding motif protein 23 "GO:0003723,GO:0005515,GO:0005634,GO:0006397,GO:0008380,GO:0016020,GO:0045893,GO:0048024" "RNA binding|protein binding|nucleus|mRNA processing|RNA splicing|membrane|positive regulation of transcription, DNA-templated|regulation of mRNA splicing, via spliceosome" RBM24 203.9927877 205.0211056 202.9644698 0.989968663 -0.014545237 0.988693037 1 2.975242329 3.072272414 221662 RNA binding motif protein 24 "GO:0000381,GO:0003197,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006397,GO:0006974,GO:0008380,GO:0010830,GO:0010831,GO:0030154,GO:0035925,GO:0043488,GO:0045663,GO:0048255,GO:0061157,GO:0061158,GO:0097157,GO:1902811,GO:1905870,GO:1990715,GO:1990825,GO:2000738,GO:2000766" "regulation of alternative mRNA splicing, via spliceosome|endocardial cushion development|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytosol|mRNA processing|cellular response to DNA damage stimulus|RNA splicing|regulation of myotube differentiation|positive regulation of myotube differentiation|cell differentiation|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|positive regulation of myoblast differentiation|mRNA stabilization|mRNA destabilization|3'-UTR-mediated mRNA destabilization|pre-mRNA intronic binding|positive regulation of skeletal muscle fiber differentiation|positive regulation of 3'-UTR-mediated mRNA stabilization|mRNA CDS binding|sequence-specific mRNA binding|positive regulation of stem cell differentiation|negative regulation of cytoplasmic translation" RBM25 2175.493285 2393.266173 1957.720396 0.818011978 -0.289806127 0.366162407 1 26.90576887 22.95731005 58517 RNA binding motif protein 25 "GO:0000381,GO:0003723,GO:0003729,GO:0005515,GO:0005737,GO:0006397,GO:0008380,GO:0016607,GO:0042981" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|cytoplasm|mRNA processing|RNA splicing|nuclear speck|regulation of apoptotic process" hsa03040 Spliceosome RBM26 1188.875919 1223.021942 1154.729896 0.944161226 -0.082894858 0.810698924 1 6.988012951 6.88201781 64062 RNA binding motif protein 26 "GO:0003723,GO:0005515,GO:0005634,GO:0006397,GO:0010923,GO:0046872" RNA binding|protein binding|nucleus|mRNA processing|negative regulation of phosphatase activity|metal ion binding RBM27 1312.839602 1412.818708 1212.860497 0.858468599 -0.220162731 0.514741339 1 10.84977762 9.715411073 54439 RNA binding motif protein 27 "GO:0003723,GO:0005634,GO:0005737,GO:0006397,GO:0016607,GO:0046872" RNA binding|nucleus|cytoplasm|mRNA processing|nuclear speck|metal ion binding RBM28 935.189383 988.5671132 881.8116528 0.892009901 -0.164868371 0.645264047 1 3.206368033 2.983314058 55131 RNA binding motif protein 28 "GO:0003723,GO:0005681,GO:0005730,GO:0006397,GO:0008380" RNA binding|spliceosomal complex|nucleolus|mRNA processing|RNA splicing hsa03008 Ribosome biogenesis in eukaryotes RBM3 8360.762603 7497.479738 9224.045468 1.230286148 0.298993906 0.367507054 1 88.34827809 113.3757449 5935 RNA binding motif protein 3 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006396,GO:0006417,GO:0015934,GO:0030425,GO:0043023,GO:0045727,GO:0048026" "RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|RNA processing|regulation of translation|large ribosomal subunit|dendrite|ribosomal large subunit binding|positive regulation of translation|positive regulation of mRNA splicing, via spliceosome" RBM33 1558.515854 1571.151839 1545.87987 0.983915005 -0.0233944 0.945513535 1 7.587080278 7.786605869 155435 RNA binding motif protein 33 GO:0003723 RNA binding RBM34 627.6480759 675.9606749 579.3354769 0.857055001 -0.222540303 0.566686167 1 18.23922405 16.30538213 23029 RNA binding motif protein 34 "GO:0003723,GO:0005654,GO:0005694,GO:0005730" RNA binding|nucleoplasm|chromosome|nucleolus RBM38 713.093413 724.6785614 701.5082646 0.968026794 -0.046881114 0.904470371 1 13.98187148 14.11785164 55544 RNA binding motif protein 38 "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005829,GO:0006397,GO:0007049,GO:0008380,GO:0010830,GO:0016032,GO:0030154,GO:0043484" RNA binding|mRNA binding|protein binding|nucleus|cytosol|mRNA processing|cell cycle|RNA splicing|regulation of myotube differentiation|viral process|cell differentiation|regulation of RNA splicing RBM39 5019.585469 5062.60037 4976.570568 0.983006796 -0.024726705 0.939246834 1 42.95574618 44.04470621 9584 RNA binding motif protein 39 "GO:0003723,GO:0005515,GO:0005654,GO:0006396,GO:0006397,GO:0008380,GO:0015630,GO:0016607,GO:0032991,GO:0034451,GO:0048024,GO:0050733" "RNA binding|protein binding|nucleoplasm|RNA processing|mRNA processing|RNA splicing|microtubule cytoskeleton|nuclear speck|protein-containing complex|centriolar satellite|regulation of mRNA splicing, via spliceosome|RS domain binding" RBM4 698.4777503 735.8430771 661.1124235 0.898442133 -0.15450251 0.684764573 1 9.019326223 8.452401827 5936 RNA binding motif protein 4 "GO:0000381,GO:0000398,GO:0002190,GO:0002192,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006396,GO:0008270,GO:0010494,GO:0016607,GO:0017148,GO:0030154,GO:0030332,GO:0032055,GO:0035198,GO:0035278,GO:0043153,GO:0045947,GO:0046685,GO:0046822,GO:0051149,GO:0097157,GO:0097158,GO:0097167" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|cap-independent translational initiation|IRES-dependent translational initiation of linear mRNA|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|RNA processing|zinc ion binding|cytoplasmic stress granule|nuclear speck|negative regulation of translation|cell differentiation|cyclin binding|negative regulation of translation in response to stress|miRNA binding|miRNA mediated inhibition of translation|entrainment of circadian clock by photoperiod|negative regulation of translational initiation|response to arsenic-containing substance|regulation of nucleocytoplasmic transport|positive regulation of muscle cell differentiation|pre-mRNA intronic binding|pre-mRNA intronic pyrimidine-rich binding|circadian regulation of translation" RBM41 473.5474748 446.5806261 500.5143236 1.120770348 0.164490692 0.69439325 1 3.159342544 3.693424942 55285 RNA binding motif protein 41 "GO:0000398,GO:0005515,GO:0005689,GO:0030626,GO:0097157" "mRNA splicing, via spliceosome|protein binding|U12-type spliceosomal complex|U12 snRNA binding|pre-mRNA intronic binding" RBM42 1045.684734 1032.21022 1059.159248 1.026108081 0.037182699 0.91805479 1 30.89704859 33.06937854 79171 RNA binding motif protein 42 "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0048025,GO:1990904" "RNA binding|protein binding|nucleus|cytoplasm|negative regulation of mRNA splicing, via spliceosome|ribonucleoprotein complex" RBM43 186.4213317 216.1856213 156.6570422 0.724641358 -0.464660946 0.401034981 1 2.621896327 1.981775989 375287 RNA binding motif protein 43 "GO:0003723,GO:0005515" RNA binding|protein binding RBM44 8.493513748 8.119647747 8.867379749 1.092089217 0.12709072 1 1 0.071555858 0.081511567 375316 RNA binding motif protein 44 "GO:0003723,GO:0005737,GO:0042803,GO:0045171" RNA binding|cytoplasm|protein homodimerization activity|intercellular bridge RBM45 139.8642476 165.4378228 114.2906723 0.690837623 -0.53358144 0.380503119 1 3.636650216 2.620555985 129831 RNA binding motif protein 45 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007399,GO:0030154,GO:1990904" RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|nervous system development|cell differentiation|ribonucleoprotein complex RBM47 59.70697443 74.09178569 45.32216316 0.61170294 -0.709096884 0.379780254 1 0.381117973 0.243173322 54502 RNA binding motif protein 47 "GO:0002244,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0016554" hematopoietic progenitor cell differentiation|RNA binding|mRNA binding|protein binding|nucleus|cytidine to uridine editing RBM48 256.8501702 248.6642123 265.0361281 1.065839453 0.091990142 0.86023943 1 2.399764694 2.667941985 84060 RNA binding motif protein 48 "GO:0003723,GO:0005515,GO:0005654" RNA binding|protein binding|nucleoplasm RBM4B 458.1813585 507.4779842 408.8847329 0.805719156 -0.31165104 0.456886164 1 9.480623248 7.967764824 83759 RNA binding motif protein 4B "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006417,GO:0007623,GO:0008270,GO:0016607,GO:0032922,GO:0032991,GO:0043153" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|nucleolus|cytosol|regulation of translation|circadian rhythm|zinc ion binding|nuclear speck|circadian regulation of gene expression|protein-containing complex|entrainment of circadian clock by photoperiod" RBM5 2155.342869 1992.358566 2318.327172 1.163609408 0.218606867 0.495831894 1 32.34164511 39.25412138 10181 RNA binding motif protein 5 "GO:0000245,GO:0000381,GO:0000398,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006396,GO:0006915,GO:0008285,GO:0043065,GO:0046872" "spliceosomal complex assembly|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|RNA processing|apoptotic process|negative regulation of cell population proliferation|positive regulation of apoptotic process|metal ion binding" RBM6 1453.558224 1535.62838 1371.488068 0.893111957 -0.163087058 0.625011421 1 17.01469265 15.85060859 10180 RNA binding motif protein 6 "GO:0000398,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0006396" "mRNA splicing, via spliceosome|DNA binding|RNA binding|protein binding|nucleus|RNA processing" RBM7 738.6724315 823.1292904 654.2155726 0.794790782 -0.331352954 0.375265076 1 11.54808718 9.573677757 10179 RNA binding motif protein 7 "GO:0000381,GO:0003723,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0016076,GO:0017069,GO:0051321,GO:0071889,GO:0097157" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|snRNA catabolic process|snRNA binding|meiotic cell cycle|14-3-3 protein binding|pre-mRNA intronic binding" RBM8A 2497.180633 2595.242411 2399.118854 0.924429581 -0.11336467 0.723055334 1 26.77528471 25.81807519 9939 RNA binding motif protein 8A "GO:0000184,GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0006417,GO:0008380,GO:0016607,GO:0030425,GO:0031124,GO:0035145,GO:0043025,GO:0071006,GO:0071013" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|regulation of translation|RNA splicing|nuclear speck|dendrite|mRNA 3'-end processing|exon-exon junction complex|neuronal cell body|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome RBMS1 960.6078195 1042.35978 878.8558596 0.843140609 -0.246154848 0.488569773 1 11.78389411 10.36345983 5937 RNA binding motif single stranded interacting protein 1 "GO:0003690,GO:0003697,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005829,GO:0006260,GO:0006396,GO:0008143,GO:0008266,GO:1990904" double-stranded DNA binding|single-stranded DNA binding|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytosol|DNA replication|RNA processing|poly(A) binding|poly(U) RNA binding|ribonucleoprotein complex RBMS2 1269.643353 1154.004936 1385.28177 1.200412343 0.263530059 0.437508897 1 6.026010818 7.545296131 5939 RNA binding motif single stranded interacting protein 2 "GO:0003723,GO:0003730,GO:0005634,GO:0005829,GO:0006396,GO:0008143,GO:0008266,GO:1990904" RNA binding|mRNA 3'-UTR binding|nucleus|cytosol|RNA processing|poly(A) binding|poly(U) RNA binding|ribonucleoprotein complex RBMS3 151.9722119 151.2284393 152.7159846 1.009836412 0.014121604 0.993631097 1 2.571923085 2.709099353 27303 RNA binding motif single stranded interacting protein 3 "GO:0002357,GO:0003723,GO:0003730,GO:0005634,GO:0005737,GO:0005829,GO:0008143,GO:0008266,GO:0010628,GO:0010629,GO:0035925,GO:0090090,GO:1990904" defense response to tumor cell|RNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|cytosol|poly(A) binding|poly(U) RNA binding|positive regulation of gene expression|negative regulation of gene expression|mRNA 3'-UTR AU-rich region binding|negative regulation of canonical Wnt signaling pathway|ribonucleoprotein complex RBMX 4728.356449 4619.064612 4837.648285 1.047322064 0.066705157 0.835530793 1 70.54865124 77.06991822 27316 RNA binding motif protein X-linked "GO:0000381,GO:0000398,GO:0000791,GO:0000978,GO:0001649,GO:0003682,GO:0003723,GO:0003727,GO:0003729,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005681,GO:0006366,GO:0006376,GO:0006509,GO:0016020,GO:0016070,GO:0019904,GO:0032991,GO:0042802,GO:0044530,GO:0045944,GO:0048025,GO:0048026,GO:0051260,GO:0070062,GO:0071013,GO:0071347,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|euchromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|osteoblast differentiation|chromatin binding|RNA binding|single-stranded RNA binding|mRNA binding|protein binding|extracellular space|nucleus|nucleoplasm|spliceosomal complex|transcription by RNA polymerase II|mRNA splice site selection|membrane protein ectodomain proteolysis|membrane|RNA metabolic process|protein domain specific binding|protein-containing complex|identical protein binding|supraspliceosomal complex|positive regulation of transcription by RNA polymerase II|negative regulation of mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|protein homooligomerization|extracellular exosome|catalytic step 2 spliceosome|cellular response to interleukin-1|ribonucleoprotein complex" hsa03040 Spliceosome RBMX2 569.9467651 536.9117073 602.9818229 1.12305583 0.167429649 0.674685559 1 14.91644754 17.47361173 51634 RNA binding motif protein X-linked 2 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005686,GO:0071005,GO:0071011" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|U2 snRNP|U2-type precatalytic spliceosome|precatalytic spliceosome" RBMXL1 701.8195337 762.2319322 641.4071352 0.841485522 -0.248989646 0.510532424 1 8.116980314 7.12454396 494115 RBMX like 1 "GO:0003723,GO:0005681,GO:0006397,GO:0008380,GO:0048026" "RNA binding|spliceosomal complex|mRNA processing|RNA splicing|positive regulation of mRNA splicing, via spliceosome" hsa03040 Spliceosome RBP4 821.8020736 343.0551173 1300.54903 3.791078938 1.922608497 3.69E-07 0.000192348 13.35475132 52.80980484 5950 retinol binding protein 4 "GO:0001523,GO:0001654,GO:0002639,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006094,GO:0007507,GO:0007601,GO:0016918,GO:0019841,GO:0030277,GO:0030324,GO:0032024,GO:0032526,GO:0032991,GO:0034632,GO:0034633,GO:0042572,GO:0042593,GO:0044877,GO:0045471,GO:0048562,GO:0048706,GO:0048738,GO:0048807,GO:0060044,GO:0060059,GO:0060065,GO:0060068,GO:0060157,GO:0060347,GO:0070062" retinoid metabolic process|eye development|positive regulation of immunoglobulin production|protein binding|extracellular region|extracellular space|cytosol|gluconeogenesis|heart development|visual perception|retinal binding|retinol binding|maintenance of gastrointestinal epithelium|lung development|positive regulation of insulin secretion|response to retinoic acid|protein-containing complex|retinol transmembrane transporter activity|retinol transport|retinol metabolic process|glucose homeostasis|protein-containing complex binding|response to ethanol|embryonic organ morphogenesis|embryonic skeletal system development|cardiac muscle tissue development|female genitalia morphogenesis|negative regulation of cardiac muscle cell proliferation|embryonic retina morphogenesis in camera-type eye|uterus development|vagina development|urinary bladder development|heart trabecula formation|extracellular exosome RBP5 6.552676467 10.14955968 2.95579325 0.291223791 -1.779799875 0.306941875 1 0.349686662 0.106223803 83758 retinol binding protein 5 "GO:0005501,GO:0005515,GO:0005737,GO:0016918,GO:0019841,GO:0070062" retinoid binding|protein binding|cytoplasm|retinal binding|retinol binding|extracellular exosome RBP7 58.33571984 47.70293051 68.96850916 1.445791871 0.531859884 0.517238988 1 3.865576231 5.829562335 116362 retinol binding protein 7 "GO:0005515,GO:0005737,GO:0016918,GO:0019841" protein binding|cytoplasm|retinal binding|retinol binding RBPJ 1462.331086 1596.525738 1328.136434 0.831891652 -0.265532455 0.424925659 1 11.78178587 10.22336393 3516 recombination signal binding protein for immunoglobulin kappa J region "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001103,GO:0001228,GO:0001525,GO:0001756,GO:0001837,GO:0001974,GO:0002193,GO:0002437,GO:0003139,GO:0003151,GO:0003160,GO:0003176,GO:0003177,GO:0003198,GO:0003214,GO:0003222,GO:0003256,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006367,GO:0006959,GO:0007219,GO:0007221,GO:0008134,GO:0008285,GO:0009912,GO:0009957,GO:0010628,GO:0017053,GO:0021983,GO:0030183,GO:0030216,GO:0030279,GO:0030513,GO:0035019,GO:0035912,GO:0036302,GO:0042742,GO:0043011,GO:0043565,GO:0045596,GO:0045747,GO:0045892,GO:0045944,GO:0047485,GO:0048505,GO:0048733,GO:0048820,GO:0060045,GO:0060412,GO:0060486,GO:0060716,GO:0060844,GO:0061314,GO:0061419,GO:0070491,GO:0072554,GO:0097101,GO:0120163,GO:1901186,GO:1901189,GO:1901297,GO:2000138" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|somitogenesis|epithelial to mesenchymal transition|blood vessel remodeling|MAML1-RBP-Jkappa- ICN1 complex|inflammatory response to antigenic stimulus|secondary heart field specification|outflow tract morphogenesis|endocardium morphogenesis|aortic valve development|pulmonary valve development|epithelial to mesenchymal transition involved in endocardial cushion formation|cardiac left ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|transcription initiation from RNA polymerase II promoter|humoral immune response|Notch signaling pathway|positive regulation of transcription of Notch receptor target|transcription factor binding|negative regulation of cell population proliferation|auditory receptor cell fate commitment|epidermal cell fate specification|positive regulation of gene expression|transcription repressor complex|pituitary gland development|B cell differentiation|keratinocyte differentiation|negative regulation of ossification|positive regulation of BMP signaling pathway|somatic stem cell population maintenance|dorsal aorta morphogenesis|atrioventricular canal development|defense response to bacterium|myeloid dendritic cell differentiation|sequence-specific DNA binding|negative regulation of cell differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|regulation of timing of cell differentiation|sebaceous gland development|hair follicle maturation|positive regulation of cardiac muscle cell proliferation|ventricular septum morphogenesis|club cell differentiation|labyrinthine layer blood vessel development|arterial endothelial cell fate commitment|Notch signaling involved in heart development|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|repressing transcription factor binding|blood vessel lumenization|blood vessel endothelial cell fate specification|negative regulation of cold-induced thermogenesis|positive regulation of ERBB signaling pathway|positive regulation of ephrin receptor signaling pathway|positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|positive regulation of cell proliferation involved in heart morphogenesis" "hsa04330,hsa04658,hsa05017,hsa05165,hsa05169,hsa05203" Notch signaling pathway|Th1 and Th2 cell differentiation|Spinocerebellar ataxia|Human papillomavirus infection|Epstein-Barr virus infection|Viral carcinogenesis TIG RBPMS 423.1856666 371.4738844 474.8974488 1.278414092 0.354355217 0.40740295 1 3.407687333 4.544093082 11030 "RNA binding protein, mRNA processing factor" "GO:0000932,GO:0003713,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005829,GO:0006396,GO:0006979,GO:0008143,GO:0010494,GO:0010862,GO:0042803,GO:0045893,GO:0060391" "P-body|transcription coactivator activity|RNA binding|mRNA binding|protein binding|nucleoplasm|cytosol|RNA processing|response to oxidative stress|poly(A) binding|cytoplasmic stress granule|positive regulation of pathway-restricted SMAD protein phosphorylation|protein homodimerization activity|positive regulation of transcription, DNA-templated|positive regulation of SMAD protein signal transduction" RBPMS2 414.4276505 311.5914823 517.2638187 1.660070471 0.731244486 0.089129417 1 7.824000669 13.54787975 348093 "RNA binding protein, mRNA processing factor 2" "GO:0003729,GO:0005515,GO:0005737,GO:0030514,GO:0042802,GO:0042803,GO:0048557,GO:0048661,GO:0051151" mRNA binding|protein binding|cytoplasm|negative regulation of BMP signaling pathway|identical protein binding|protein homodimerization activity|embryonic digestive tract morphogenesis|positive regulation of smooth muscle cell proliferation|negative regulation of smooth muscle cell differentiation RBSN 1455.797461 1351.92135 1559.673571 1.153671825 0.206232892 0.536014966 1 9.640952841 11.60160767 64145 "rabenosyn, RAB effector" "GO:0005515,GO:0005768,GO:0005829,GO:0005886,GO:0007596,GO:0008270,GO:0010008,GO:0015031,GO:0016197,GO:0031901,GO:0034498,GO:0043231,GO:0070062,GO:0090160,GO:1903358" protein binding|endosome|cytosol|plasma membrane|blood coagulation|zinc ion binding|endosome membrane|protein transport|endosomal transport|early endosome membrane|early endosome to Golgi transport|intracellular membrane-bounded organelle|extracellular exosome|Golgi to lysosome transport|regulation of Golgi organization hsa04144 Endocytosis RBX1 949.2139363 903.3108119 995.1170607 1.101633068 0.139643771 0.696271785 1 39.13559104 44.97019704 9978 ring-box 1 "GO:0000165,GO:0000209,GO:0000715,GO:0000717,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006283,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006511,GO:0006513,GO:0008134,GO:0008270,GO:0010265,GO:0010972,GO:0016032,GO:0016055,GO:0016567,GO:0018215,GO:0019005,GO:0019788,GO:0030891,GO:0031146,GO:0031461,GO:0031462,GO:0031463,GO:0031464,GO:0031465,GO:0031466,GO:0031467,GO:0031625,GO:0032436,GO:0033683,GO:0034450,GO:0042769,GO:0043161,GO:0043687,GO:0044877,GO:0045116,GO:0061418,GO:0061630,GO:0061663,GO:0070498,GO:0070911,GO:0070936,GO:0090090,GO:0097602,GO:1902499" "MAPK cascade|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|ubiquitin-dependent protein catabolic process|protein monoubiquitination|transcription factor binding|zinc ion binding|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|viral process|Wnt signaling pathway|protein ubiquitination|protein phosphopantetheinylation|SCF ubiquitin ligase complex|NEDD8 transferase activity|VCB complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|Cul2-RING ubiquitin ligase complex|Cul3-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|Cul5-RING ubiquitin ligase complex|Cul7-RING ubiquitin ligase complex|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA incision|ubiquitin-ubiquitin ligase activity|DNA damage response, detection of DNA damage|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|protein-containing complex binding|protein neddylation|regulation of transcription from RNA polymerase II promoter in response to hypoxia|ubiquitin protein ligase activity|NEDD8 ligase activity|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|protein K48-linked ubiquitination|negative regulation of canonical Wnt signaling pathway|cullin family protein binding|positive regulation of protein autoubiquitination" "hsa03420,hsa04066,hsa04110,hsa04114,hsa04120,hsa04141,hsa04310,hsa04350,hsa04710,hsa05131,hsa05170,hsa05200,hsa05211" Nucleotide excision repair|HIF-1 signaling pathway|Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Wnt signaling pathway|TGF-beta signaling pathway|Circadian rhythm|Shigellosis|Human immunodeficiency virus 1 infection|Pathways in cancer|Renal cell carcinoma RC3H1 461.8376248 521.6873677 401.987882 0.770553222 -0.376033488 0.367765117 1 2.319517582 1.864301887 149041 ring finger and CCCH-type domains 1 "GO:0000209,GO:0000288,GO:0000932,GO:0000956,GO:0001782,GO:0002634,GO:0002635,GO:0003723,GO:0003725,GO:0003729,GO:0003730,GO:0004842,GO:0005515,GO:0006511,GO:0008270,GO:0010494,GO:0010608,GO:0030889,GO:0033962,GO:0035198,GO:0035613,GO:0042098,GO:0043029,GO:0043488,GO:0045623,GO:0046007,GO:0048535,GO:0048536,GO:0050852,GO:0050856,GO:0061014,GO:0061158,GO:0061470,GO:0061630,GO:0071347,GO:1901224,GO:2000320,GO:2000628" "protein polyubiquitination|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|P-body|nuclear-transcribed mRNA catabolic process|B cell homeostasis|regulation of germinal center formation|negative regulation of germinal center formation|RNA binding|double-stranded RNA binding|mRNA binding|mRNA 3'-UTR binding|ubiquitin-protein transferase activity|protein binding|ubiquitin-dependent protein catabolic process|zinc ion binding|cytoplasmic stress granule|posttranscriptional regulation of gene expression|negative regulation of B cell proliferation|P-body assembly|miRNA binding|RNA stem-loop binding|T cell proliferation|T cell homeostasis|regulation of mRNA stability|negative regulation of T-helper cell differentiation|negative regulation of activated T cell proliferation|lymph node development|spleen development|T cell receptor signaling pathway|regulation of T cell receptor signaling pathway|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|T follicular helper cell differentiation|ubiquitin protein ligase activity|cellular response to interleukin-1|positive regulation of NIK/NF-kappaB signaling|negative regulation of T-helper 17 cell differentiation|regulation of miRNA metabolic process" RC3H2 2627.405766 2337.443595 2917.367937 1.248101962 0.319735798 0.315906927 1 11.05868959 14.39692239 54542 ring finger and CCCH-type domains 2 "GO:0000209,GO:0000288,GO:0000932,GO:0001782,GO:0003677,GO:0003723,GO:0003725,GO:0003729,GO:0006511,GO:0009791,GO:0009986,GO:0010494,GO:0016020,GO:0035264,GO:0035613,GO:0042098,GO:0043029,GO:0043231,GO:0043488,GO:0046872,GO:0048286,GO:0048535,GO:0048536,GO:0050852,GO:0060173,GO:0061470,GO:0061630,GO:1901224,GO:2000320,GO:2000628" "protein polyubiquitination|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|P-body|B cell homeostasis|DNA binding|RNA binding|double-stranded RNA binding|mRNA binding|ubiquitin-dependent protein catabolic process|post-embryonic development|cell surface|cytoplasmic stress granule|membrane|multicellular organism growth|RNA stem-loop binding|T cell proliferation|T cell homeostasis|intracellular membrane-bounded organelle|regulation of mRNA stability|metal ion binding|lung alveolus development|lymph node development|spleen development|T cell receptor signaling pathway|limb development|T follicular helper cell differentiation|ubiquitin protein ligase activity|positive regulation of NIK/NF-kappaB signaling|negative regulation of T-helper 17 cell differentiation|regulation of miRNA metabolic process" RCAN1 470.6307757 516.6125879 424.6489635 0.821987256 -0.282812068 0.49689658 1 4.337633468 3.719065825 1827 regulator of calcineurin 1 "GO:0003676,GO:0005515,GO:0005634,GO:0005737,GO:0008597,GO:0019722,GO:0033173,GO:0043666,GO:0070885" nucleic acid binding|protein binding|nucleus|cytoplasm|calcium-dependent protein serine/threonine phosphatase regulator activity|calcium-mediated signaling|calcineurin-NFAT signaling cascade|regulation of phosphoprotein phosphatase activity|negative regulation of calcineurin-NFAT signaling cascade "hsa04919,hsa04921,hsa05167" Thyroid hormone signaling pathway|Oxytocin signaling pathway|Kaposi sarcoma-associated herpesvirus infection RCAN2 23.97295307 22.3290313 25.61687483 1.147245238 0.198173818 0.888701409 1 0.280477843 0.335637712 10231 regulator of calcineurin 2 "GO:0003676,GO:0005575,GO:0005634,GO:0005737,GO:0008597,GO:0019722,GO:0043666" nucleic acid binding|cellular_component|nucleus|cytoplasm|calcium-dependent protein serine/threonine phosphatase regulator activity|calcium-mediated signaling|regulation of phosphoprotein phosphatase activity hsa04919 Thyroid hormone signaling pathway RCAN3 188.4769759 87.28621328 289.6677385 3.31859669 1.730573309 0.00212844 0.147899168 1.442329127 4.992692049 11123 RCAN family member 3 "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0008597,GO:0009653,GO:0019722,GO:0019902,GO:0031013,GO:0043666" RNA binding|protein binding|nucleus|cytoplasm|calcium-dependent protein serine/threonine phosphatase regulator activity|anatomical structure morphogenesis|calcium-mediated signaling|phosphatase binding|troponin I binding|regulation of phosphoprotein phosphatase activity RCBTB1 606.45821 574.4650781 638.4513419 1.111384079 0.152357479 0.698569448 1 5.470972098 6.342268161 55213 RCC1 and BTB domain containing protein 1 "GO:0005634,GO:0005737,GO:0006325,GO:0007049" nucleus|cytoplasm|chromatin organization|cell cycle RCBTB2 99.53323281 102.5105528 96.55591282 0.941911932 -0.08633592 0.913587698 1 0.942250066 0.925747195 1102 RCC1 and BTB domain containing protein 2 "GO:0001669,GO:0005085,GO:0005515,GO:0050790" acrosomal vesicle|guanyl-nucleotide exchange factor activity|protein binding|regulation of catalytic activity RCC1 1547.615841 1600.585562 1494.64612 0.933812072 -0.098795856 0.766165154 1 30.23648347 29.45145089 1104 regulator of chromosome condensation 1 "GO:0000082,GO:0000785,GO:0000794,GO:0003682,GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007052,GO:0007059,GO:0007088,GO:0016032,GO:0031267,GO:0031291,GO:0031491,GO:0031492,GO:0031965,GO:0032991,GO:0042393,GO:0043199,GO:0046982,GO:0050790,GO:0051225,GO:0051301,GO:1901673" G1/S transition of mitotic cell cycle|chromatin|condensed nuclear chromosome|chromatin binding|guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitotic spindle organization|chromosome segregation|regulation of mitotic nuclear division|viral process|small GTPase binding|Ran protein signal transduction|nucleosome binding|nucleosomal DNA binding|nuclear membrane|protein-containing complex|histone binding|sulfate binding|protein heterodimerization activity|regulation of catalytic activity|spindle assembly|cell division|regulation of mitotic spindle assembly RCC1L 1410.561651 1391.504633 1429.618668 1.02739052 0.038984667 0.909195834 1 18.96523162 20.324021 81554 RCC1 like "GO:0003723,GO:0005085,GO:0005515,GO:0005525,GO:0005743,GO:0019843,GO:0031966,GO:0050790,GO:0070131,GO:1990613" RNA binding|guanyl-nucleotide exchange factor activity|protein binding|GTP binding|mitochondrial inner membrane|rRNA binding|mitochondrial membrane|regulation of catalytic activity|positive regulation of mitochondrial translation|mitochondrial membrane fusion RCC2 2269.681546 2871.310435 1668.052657 0.580937762 -0.783544485 0.014768682 0.53522651 35.87117517 21.73657638 55920 regulator of chromosome condensation 2 "GO:0003723,GO:0005085,GO:0005515,GO:0005730,GO:0005829,GO:0005874,GO:0005886,GO:0007049,GO:0007229,GO:0008017,GO:0010762,GO:0010971,GO:0016020,GO:0019901,GO:0019904,GO:0030334,GO:0030496,GO:0031267,GO:0031901,GO:0034260,GO:0034506,GO:0045184,GO:0048041,GO:0051301,GO:0051895,GO:0051987,GO:0072356,GO:0090630,GO:1900025,GO:1900027,GO:1990023" "RNA binding|guanyl-nucleotide exchange factor activity|protein binding|nucleolus|cytosol|microtubule|plasma membrane|cell cycle|integrin-mediated signaling pathway|microtubule binding|regulation of fibroblast migration|positive regulation of G2/M transition of mitotic cell cycle|membrane|protein kinase binding|protein domain specific binding|regulation of cell migration|midbody|small GTPase binding|early endosome membrane|negative regulation of GTPase activity|chromosome, centromeric core domain|establishment of protein localization|focal adhesion assembly|cell division|negative regulation of focal adhesion assembly|positive regulation of attachment of spindle microtubules to kinetochore|chromosome passenger complex localization to kinetochore|activation of GTPase activity|negative regulation of substrate adhesion-dependent cell spreading|regulation of ruffle assembly|mitotic spindle midzone" RCCD1 463.3979152 426.2815067 500.5143236 1.174140364 0.231604888 0.580364961 1 7.825173789 9.583627823 91433 RCC1 domain containing 1 "GO:0005515,GO:0005694,GO:0005829,GO:0005886,GO:0006325" protein binding|chromosome|cytosol|plasma membrane|chromatin organization RCE1 427.0322064 432.3712425 421.6931703 0.975303463 -0.036076915 0.938221623 1 14.97816561 15.23752125 9986 Ras converting CAAX endopeptidase 1 "GO:0004175,GO:0004197,GO:0004222,GO:0005789,GO:0005829,GO:0005887,GO:0008238,GO:0016020,GO:0016579,GO:0018342,GO:0030176,GO:0071586" endopeptidase activity|cysteine-type endopeptidase activity|metalloendopeptidase activity|endoplasmic reticulum membrane|cytosol|integral component of plasma membrane|exopeptidase activity|membrane|protein deubiquitination|protein prenylation|integral component of endoplasmic reticulum membrane|CAAX-box protein processing hsa00900 Terpenoid backbone biosynthesis RCHY1 287.4054912 283.1727152 291.6382673 1.029895367 0.042497773 0.936928089 1 3.205565277 3.443607612 25898 ring finger and CHY zinc finger domain containing 1 "GO:0000151,GO:0002039,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0008270,GO:0016567,GO:0016607,GO:0031398,GO:0032436,GO:0042803,GO:0043231,GO:0061630,GO:0070987" ubiquitin ligase complex|p53 binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|protein ubiquitination|nuclear speck|positive regulation of protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|ubiquitin protein ligase activity|error-free translesion synthesis "hsa04115,hsa04120,hsa05162" p53 signaling pathway|Ubiquitin mediated proteolysis|Measles RCL1 231.3493399 290.277407 172.4212729 0.593987919 -0.751494506 0.144292289 1 6.045035619 3.745349979 10171 RNA terminal phosphate cyclase like 1 "GO:0000447,GO:0000479,GO:0000480,GO:0004521,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0008150" "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endoribonuclease activity|protein binding|nucleoplasm|nucleolus|rRNA processing|biological_process" hsa03008 Ribosome biogenesis in eukaryotes RCN1 5692.25162 6357.684186 5026.819053 0.790668254 -0.338855595 0.294876528 1 135.9199137 112.0968275 5954 reticulocalbin 1 "GO:0001701,GO:0005509,GO:0005515,GO:0005783,GO:0005788,GO:0043010,GO:0043687,GO:0044267" in utero embryonic development|calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|camera-type eye development|post-translational protein modification|cellular protein metabolic process RCN2 2319.070706 2240.007822 2398.13359 1.070591614 0.098408257 0.759099933 1 18.08808895 20.19912013 5955 reticulocalbin 2 "GO:0005509,GO:0005515,GO:0005730,GO:0005783,GO:0005788" calcium ion binding|protein binding|nucleolus|endoplasmic reticulum|endoplasmic reticulum lumen RCN3 65.05169984 69.01700585 61.08639383 0.885091914 -0.176100812 0.838404083 1 1.744245444 1.610318937 57333 reticulocalbin 3 "GO:0005509,GO:0005515,GO:0005783,GO:0005788,GO:0009306,GO:0010952,GO:0015031,GO:0032964,GO:0036503,GO:0043129,GO:0043231,GO:0051896,GO:0055091,GO:0060428" calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein secretion|positive regulation of peptidase activity|protein transport|collagen biosynthetic process|ERAD pathway|surfactant homeostasis|intracellular membrane-bounded organelle|regulation of protein kinase B signaling|phospholipid homeostasis|lung epithelium development RCOR1 1143.79401 1205.76769 1081.820329 0.897204609 -0.156491063 0.650970969 1 10.61865412 9.937494479 23186 REST corepressor 1 "GO:0000118,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0007596,GO:0016032,GO:0016575,GO:0017053,GO:0019899,GO:0030218,GO:0045654,GO:0045892,GO:0070933,GO:1990391" "histone deacetylase complex|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|blood coagulation|viral process|histone deacetylation|transcription repressor complex|enzyme binding|erythrocyte differentiation|positive regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|histone H4 deacetylation|DNA repair complex" hsa05016 Huntington disease MYB RCOR2 53.15429796 63.94222601 42.36636991 0.662572647 -0.59384945 0.481358693 1 1.110959922 0.767799499 283248 REST corepressor 2 "GO:0000118,GO:0003714,GO:0005515,GO:0005667,GO:0006357,GO:0016575,GO:0019899,GO:0045892" "histone deacetylase complex|transcription corepressor activity|protein binding|transcription regulator complex|regulation of transcription by RNA polymerase II|histone deacetylation|enzyme binding|negative regulation of transcription, DNA-templated" RCOR3 611.8838453 675.9606749 547.8070156 0.810412552 -0.303271576 0.436584832 1 5.794689157 4.898377289 55758 REST corepressor 3 "GO:0000118,GO:0003714,GO:0005515,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0016575,GO:0045892" "histone deacetylase complex|transcription corepressor activity|protein binding|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|histone deacetylation|negative regulation of transcription, DNA-templated" RDH10 111.2200722 126.869496 95.57064841 0.753298873 -0.408705724 0.53685604 1 1.623008943 1.275275923 157506 retinol dehydrogenase 10 "GO:0001523,GO:0001656,GO:0001701,GO:0002138,GO:0004745,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0005811,GO:0007601,GO:0008406,GO:0014032,GO:0016021,GO:0016616,GO:0031076,GO:0035115,GO:0042572,GO:0042574,GO:0043583,GO:0043584,GO:0048703,GO:0052650,GO:0055114,GO:0060431,GO:0060449,GO:1900054" "retinoid metabolic process|metanephros development|in utero embryonic development|retinoic acid biosynthetic process|retinol dehydrogenase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|lipid droplet|visual perception|gonad development|neural crest cell development|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|embryonic camera-type eye development|embryonic forelimb morphogenesis|retinol metabolic process|retinal metabolic process|ear development|nose development|embryonic viscerocranium morphogenesis|NADP-retinol dehydrogenase activity|oxidation-reduction process|primary lung bud formation|bud elongation involved in lung branching|positive regulation of retinoic acid biosynthetic process" hsa00830 Retinol metabolism RDH11 2034.286236 2034.986717 2033.585756 0.999311563 -0.000993547 0.999292998 1 40.59271296 42.31213308 51109 retinol dehydrogenase 11 "GO:0001523,GO:0004745,GO:0005515,GO:0005789,GO:0016021,GO:0016616,GO:0042572,GO:0042574,GO:0052650,GO:0055114,GO:0110095" "retinoid metabolic process|retinol dehydrogenase activity|protein binding|endoplasmic reticulum membrane|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|retinol metabolic process|retinal metabolic process|NADP-retinol dehydrogenase activity|oxidation-reduction process|cellular detoxification of aldehyde" hsa00830 Retinol metabolism RDH12 5.493183171 5.074779842 5.911586499 1.164895165 0.220200125 1 1 0.136858198 0.166292855 145226 retinol dehydrogenase 12 "GO:0001523,GO:0001917,GO:0004745,GO:0005515,GO:0005789,GO:0007601,GO:0042572,GO:0045494,GO:0052650,GO:0055114,GO:0060342,GO:0110095" retinoid metabolic process|photoreceptor inner segment|retinol dehydrogenase activity|protein binding|endoplasmic reticulum membrane|visual perception|retinol metabolic process|photoreceptor cell maintenance|NADP-retinol dehydrogenase activity|oxidation-reduction process|photoreceptor inner segment membrane|cellular detoxification of aldehyde hsa00830 Retinol metabolism RDH13 140.0005812 141.0788796 138.9222827 0.984713538 -0.022224002 0.98399298 1 1.483626984 1.523879274 112724 retinol dehydrogenase 13 "GO:0005743,GO:0009644,GO:0010842,GO:0042462,GO:0042572,GO:0042574,GO:0052650,GO:0055114" mitochondrial inner membrane|response to high light intensity|retina layer formation|eye photoreceptor cell development|retinol metabolic process|retinal metabolic process|NADP-retinol dehydrogenase activity|oxidation-reduction process RDH14 37.46701778 35.52345889 39.41057666 1.109423966 0.149810797 0.899447359 1 1.153293509 1.334606762 57665 retinol dehydrogenase 14 "GO:0001649,GO:0005634,GO:0005654,GO:0005765,GO:0005783,GO:0005789,GO:0005829,GO:0016020,GO:0016229,GO:0042572,GO:0052650,GO:0055114" osteoblast differentiation|nucleus|nucleoplasm|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|membrane|steroid dehydrogenase activity|retinol metabolic process|NADP-retinol dehydrogenase activity|oxidation-reduction process RDH5 29.86969379 21.31407534 38.42531225 1.802813945 0.850250515 0.396279793 1 0.844005257 1.587128135 5959 retinol dehydrogenase 5 "GO:0001523,GO:0004745,GO:0005788,GO:0005789,GO:0007601,GO:0008202,GO:0016021,GO:0042572,GO:0042803,GO:0044297,GO:0047023,GO:0047044,GO:0050896,GO:0055114" "retinoid metabolic process|retinol dehydrogenase activity|endoplasmic reticulum lumen|endoplasmic reticulum membrane|visual perception|steroid metabolic process|integral component of membrane|retinol metabolic process|protein homodimerization activity|cell body|androsterone dehydrogenase activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|response to stimulus|oxidation-reduction process" hsa00830 Retinol metabolism RDM1 12.50880029 13.19442759 11.823173 0.896073204 -0.158311499 0.970376506 1 0.350420142 0.327528036 201299 RAD52 motif containing 1 "GO:0003677,GO:0003723,GO:0005515,GO:0005730,GO:0005829,GO:0015030,GO:0016605" DNA binding|RNA binding|protein binding|nucleolus|cytosol|Cajal body|PML body RDX 2527.89802 2472.432739 2583.3633 1.044866968 0.063319271 0.843653584 1 23.15458506 25.23561728 5962 radixin "GO:0003723,GO:0003779,GO:0005515,GO:0005615,GO:0005886,GO:0005902,GO:0005912,GO:0005925,GO:0008360,GO:0008361,GO:0010628,GO:0010737,GO:0016324,GO:0030027,GO:0030175,GO:0030315,GO:0030335,GO:0030496,GO:0030864,GO:0032154,GO:0032231,GO:0032487,GO:0034111,GO:0034260,GO:0036120,GO:0043087,GO:0045176,GO:0045184,GO:0045296,GO:0045792,GO:0051016,GO:0051018,GO:0051117,GO:0051286,GO:0061028,GO:0070062,GO:0071944,GO:0072659,GO:0097067,GO:1900027,GO:1900087,GO:1902115,GO:1902966,GO:1903364,GO:1903392,GO:2000643" RNA binding|actin binding|protein binding|extracellular space|plasma membrane|microvillus|adherens junction|focal adhesion|regulation of cell shape|regulation of cell size|positive regulation of gene expression|protein kinase A signaling|apical plasma membrane|lamellipodium|filopodium|T-tubule|positive regulation of cell migration|midbody|cortical actin cytoskeleton|cleavage furrow|regulation of actin filament bundle assembly|regulation of Rap protein signal transduction|negative regulation of homotypic cell-cell adhesion|negative regulation of GTPase activity|cellular response to platelet-derived growth factor stimulus|regulation of GTPase activity|apical protein localization|establishment of protein localization|cadherin binding|negative regulation of cell size|barbed-end actin filament capping|protein kinase A binding|ATPase binding|cell tip|establishment of endothelial barrier|extracellular exosome|cell periphery|protein localization to plasma membrane|cellular response to thyroid hormone stimulus|regulation of ruffle assembly|positive regulation of G1/S transition of mitotic cell cycle|regulation of organelle assembly|positive regulation of protein localization to early endosome|positive regulation of cellular protein catabolic process|negative regulation of adherens junction organization|positive regulation of early endosome to late endosome transport "hsa04530,hsa04810,hsa05205,hsa05206" Tight junction|Regulation of actin cytoskeleton|Proteoglycans in cancer|MicroRNAs in cancer REC8 61.06882645 32.47859099 89.65906191 2.760558854 1.464960359 0.069253027 1 0.644563502 1.856002899 9985 REC8 meiotic recombination protein "GO:0000778,GO:0000795,GO:0000800,GO:0001556,GO:0001673,GO:0003682,GO:0005515,GO:0005634,GO:0007062,GO:0007064,GO:0007130,GO:0007131,GO:0007141,GO:0007283,GO:0007286,GO:0009566,GO:0034990,GO:0034991,GO:0051177,GO:0051321,GO:0072520,GO:1990414" condensed nuclear chromosome kinetochore|synaptonemal complex|lateral element|oocyte maturation|male germ cell nucleus|chromatin binding|protein binding|nucleus|sister chromatid cohesion|mitotic sister chromatid cohesion|synaptonemal complex assembly|reciprocal meiotic recombination|male meiosis I|spermatogenesis|spermatid development|fertilization|nuclear mitotic cohesin complex|nuclear meiotic cohesin complex|meiotic sister chromatid cohesion|meiotic cell cycle|seminiferous tubule development|replication-born double-strand break repair via sister chromatid exchange hsa04114 Oocyte meiosis RECK 362.3340836 421.2067269 303.4614403 0.72045725 -0.473015267 0.289568767 1 3.252421831 2.444167773 8434 reversion inducing cysteine rich protein with kazal motifs "GO:0001955,GO:0002040,GO:0004866,GO:0004867,GO:0005515,GO:0005576,GO:0005886,GO:0007566,GO:0008191,GO:0016020,GO:0017147,GO:0030198,GO:0030336,GO:0031225,GO:0035115,GO:0045765,GO:0060070,GO:0090210,GO:0090263,GO:1904684,GO:1904928,GO:1990909" blood vessel maturation|sprouting angiogenesis|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|plasma membrane|embryo implantation|metalloendopeptidase inhibitor activity|membrane|Wnt-protein binding|extracellular matrix organization|negative regulation of cell migration|anchored component of membrane|embryonic forelimb morphogenesis|regulation of angiogenesis|canonical Wnt signaling pathway|regulation of establishment of blood-brain barrier|positive regulation of canonical Wnt signaling pathway|negative regulation of metalloendopeptidase activity|coreceptor activity involved in canonical Wnt signaling pathway|Wnt signalosome hsa05206 MicroRNAs in cancer RECQL 3242.399306 2956.566736 3528.231876 1.193354384 0.255022536 0.422781957 1 42.20396703 52.53377839 5965 RecQ like helicase "GO:0000724,GO:0000733,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0006268,GO:0006281,GO:0006310,GO:0009378,GO:0016020,GO:0032508,GO:0036310,GO:0043138" double-strand break repair via homologous recombination|DNA strand renaturation|DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|cytoplasm|DNA unwinding involved in DNA replication|DNA repair|DNA recombination|four-way junction helicase activity|membrane|DNA duplex unwinding|annealing helicase activity|3'-5' DNA helicase activity RECQL4 2490.980542 2104.003722 2877.957361 1.367848037 0.45190796 0.157036256 1 26.82788672 38.27720737 9401 RecQ like helicase 4 "GO:0000405,GO:0000723,GO:0000724,GO:0000733,GO:0000781,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0005737,GO:0006260,GO:0006268,GO:0006281,GO:0006310,GO:0007275,GO:0009378,GO:0016020,GO:0032357,GO:0032508,GO:0036310,GO:0043138,GO:0061820,GO:0061821" "bubble DNA binding|telomere maintenance|double-strand break repair via homologous recombination|DNA strand renaturation|chromosome, telomeric region|helicase activity|protein binding|ATP binding|nucleus|chromosome|cytoplasm|DNA replication|DNA unwinding involved in DNA replication|DNA repair|DNA recombination|multicellular organism development|four-way junction helicase activity|membrane|oxidized purine DNA binding|DNA duplex unwinding|annealing helicase activity|3'-5' DNA helicase activity|telomeric D-loop disassembly|telomeric D-loop binding" RECQL5 528.2863115 484.1339969 572.438626 1.182397084 0.241714616 0.550343168 1 3.628244898 4.474823115 9400 RecQ like helicase 5 "GO:0000278,GO:0000724,GO:0000993,GO:0003676,GO:0003678,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006259,GO:0006260,GO:0006268,GO:0006281,GO:0006310,GO:0009378,GO:0016591,GO:0032508,GO:0034244,GO:0035690,GO:0043138,GO:0051301,GO:0051304,GO:0072757,GO:1990414,GO:2000042" "mitotic cell cycle|double-strand break repair via homologous recombination|RNA polymerase II complex binding|nucleic acid binding|DNA helicase activity|ATP binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|DNA metabolic process|DNA replication|DNA unwinding involved in DNA replication|DNA repair|DNA recombination|four-way junction helicase activity|RNA polymerase II, holoenzyme|DNA duplex unwinding|negative regulation of transcription elongation from RNA polymerase II promoter|cellular response to drug|3'-5' DNA helicase activity|cell division|chromosome separation|cellular response to camptothecin|replication-born double-strand break repair via sister chromatid exchange|negative regulation of double-strand break repair via homologous recombination" REEP1 7.015617123 8.119647747 5.911586499 0.728059478 -0.457871781 0.855058357 1 0.090241719 0.068531486 65055 receptor accessory protein 1 "GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005881,GO:0008017,GO:0016020,GO:0016021,GO:0031849,GO:0031966,GO:0051205,GO:0071782,GO:0071786" protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytoplasmic microtubule|microtubule binding|membrane|integral component of membrane|olfactory receptor binding|mitochondrial membrane|protein insertion into membrane|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization REEP2 1254.161192 1173.289099 1335.033284 1.137855355 0.186317172 0.584285974 1 27.88500881 33.09586782 51308 receptor accessory protein 2 "GO:0005515,GO:0005783,GO:0005789,GO:0005881,GO:0005887,GO:0008017,GO:0016020,GO:0031883,GO:0032386,GO:0032596,GO:0050913,GO:0050916,GO:0071782,GO:0071786" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytoplasmic microtubule|integral component of plasma membrane|microtubule binding|membrane|taste receptor binding|regulation of intracellular transport|protein transport into membrane raft|sensory perception of bitter taste|sensory perception of sweet taste|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization REEP3 2472.302333 2140.542137 2804.062529 1.30997773 0.389542285 0.222455588 1 8.499483173 11.61374699 221035 receptor accessory protein 3 "GO:0005515,GO:0005789,GO:0005881,GO:0006998,GO:0007084,GO:0008017,GO:0016020,GO:0016021,GO:0051301,GO:0071782,GO:0071786" protein binding|endoplasmic reticulum membrane|cytoplasmic microtubule|nuclear envelope organization|mitotic nuclear envelope reassembly|microtubule binding|membrane|integral component of membrane|cell division|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization REEP4 788.3770662 718.5888256 858.1653068 1.194236921 0.256089077 0.487861268 1 21.84513145 27.21203907 80346 receptor accessory protein 4 "GO:0005515,GO:0005783,GO:0005789,GO:0005881,GO:0006998,GO:0007084,GO:0008017,GO:0016020,GO:0016021,GO:0051301,GO:0071782,GO:0071786" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytoplasmic microtubule|nuclear envelope organization|mitotic nuclear envelope reassembly|microtubule binding|membrane|integral component of membrane|cell division|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization REEP5 3046.20624 2846.951491 3245.460988 1.139977621 0.189005503 0.552670941 1 27.31869071 32.48419709 7905 receptor accessory protein 5 "GO:0003674,GO:0005515,GO:0005783,GO:0007029,GO:0008150,GO:0016021,GO:0032386,GO:0071782" molecular_function|protein binding|endoplasmic reticulum|endoplasmic reticulum organization|biological_process|integral component of membrane|regulation of intracellular transport|endoplasmic reticulum tubular network REEP6 76.34982747 100.4806409 52.21901408 0.519692287 -0.944270447 0.203710429 1 3.531568345 1.914387354 92840 receptor accessory protein 6 "GO:0001917,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0007029,GO:0016021,GO:0030665,GO:0032386,GO:0050908" photoreceptor inner segment|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum organization|integral component of membrane|clathrin-coated vesicle membrane|regulation of intracellular transport|detection of light stimulus involved in visual perception REL 289.5959851 331.8906017 247.3013686 0.74512917 -0.424437553 0.375680119 1 2.118347591 1.646435487 5966 "REL proto-oncogene, NF-kB subunit" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0006954,GO:0007249,GO:0010629,GO:0032688,GO:0033554,GO:0034097,GO:0038061,GO:0043123,GO:0045087,GO:0045944,GO:1901215" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|inflammatory response|I-kappaB kinase/NF-kappaB signaling|negative regulation of gene expression|negative regulation of interferon-beta production|cellular response to stress|response to cytokine|NIK/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription by RNA polymerase II|negative regulation of neuron death" "hsa04014,hsa05202,hsa05203" Ras signaling pathway|Transcriptional misregulation in cancer|Viral carcinogenesis RHD RELA 2355.553697 2444.013972 2267.093422 0.927610664 -0.10840869 0.735196675 1 49.1778648 47.58294644 5970 "RELA proto-oncogene, NF-kB subunit" "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000979,GO:0000981,GO:0001225,GO:0001227,GO:0001228,GO:0001889,GO:0001942,GO:0002223,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0005829,GO:0006117,GO:0006325,GO:0006351,GO:0006355,GO:0006357,GO:0006954,GO:0006968,GO:0007249,GO:0007568,GO:0008134,GO:0008284,GO:0009887,GO:0010033,GO:0010224,GO:0014040,GO:0016032,GO:0019221,GO:0019899,GO:0019901,GO:0031293,GO:0031490,GO:0031625,GO:0032481,GO:0032495,GO:0032570,GO:0032735,GO:0032757,GO:0032868,GO:0033209,GO:0033234,GO:0033554,GO:0033590,GO:0033613,GO:0034097,GO:0035525,GO:0035729,GO:0035924,GO:0035994,GO:0038061,GO:0038095,GO:0042177,GO:0042277,GO:0042301,GO:0042493,GO:0042802,GO:0042803,GO:0042805,GO:0042826,GO:0043066,GO:0043123,GO:0043200,GO:0043278,GO:0043620,GO:0044877,GO:0045087,GO:0045892,GO:0045893,GO:0045944,GO:0046627,GO:0047485,GO:0050727,GO:0050852,GO:0050862,GO:0051059,GO:0051092,GO:0051591,GO:0051607,GO:0070301,GO:0070431,GO:0070491,GO:0070498,GO:0070555,GO:0071222,GO:0071223,GO:0071224,GO:0071316,GO:0071347,GO:0071354,GO:0071356,GO:0071532,GO:0098978,GO:0099527,GO:1901222,GO:1901223,GO:1901224,GO:1901522,GO:1902004,GO:1902894,GO:1902895,GO:1904385,GO:1904996,GO:2000630,GO:2001237" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription coactivator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|hair follicle development|stimulatory C-type lectin receptor signaling pathway|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|cytosol|acetaldehyde metabolic process|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|inflammatory response|cellular defense response|I-kappaB kinase/NF-kappaB signaling|aging|transcription factor binding|positive regulation of cell population proliferation|animal organ morphogenesis|response to organic substance|response to UV-B|positive regulation of Schwann cell differentiation|viral process|cytokine-mediated signaling pathway|enzyme binding|protein kinase binding|membrane protein intracellular domain proteolysis|chromatin DNA binding|ubiquitin protein ligase binding|positive regulation of type I interferon production|response to muramyl dipeptide|response to progesterone|positive regulation of interleukin-12 production|positive regulation of interleukin-8 production|response to insulin|tumor necrosis factor-mediated signaling pathway|negative regulation of protein sumoylation|cellular response to stress|response to cobalamin|activating transcription factor binding|response to cytokine|NF-kappaB p50/p65 complex|cellular response to hepatocyte growth factor stimulus|cellular response to vascular endothelial growth factor stimulus|response to muscle stretch|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|negative regulation of protein catabolic process|peptide binding|phosphate ion binding|response to drug|identical protein binding|protein homodimerization activity|actinin binding|histone deacetylase binding|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to amino acid|response to morphine|regulation of DNA-templated transcription in response to stress|protein-containing complex binding|innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of insulin receptor signaling pathway|protein N-terminus binding|regulation of inflammatory response|T cell receptor signaling pathway|positive regulation of T cell receptor signaling pathway|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|response to cAMP|defense response to virus|cellular response to hydrogen peroxide|nucleotide-binding oligomerization domain containing 2 signaling pathway|repressing transcription factor binding|interleukin-1-mediated signaling pathway|response to interleukin-1|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|cellular response to peptidoglycan|cellular response to nicotine|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to tumor necrosis factor|ankyrin repeat binding|glutamatergic synapse|postsynapse to nucleus signaling pathway|regulation of NIK/NF-kappaB signaling|negative regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of amyloid-beta formation|negative regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of pri-miRNA transcription by RNA polymerase II|cellular response to angiotensin|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of miRNA metabolic process|negative regulation of extrinsic apoptotic signaling pathway" "hsa01523,hsa04010,hsa04014,hsa04024,hsa04062,hsa04064,hsa04066,hsa04071,hsa04137,hsa04151,hsa04210,hsa04211,hsa04218,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04917,hsa04920,hsa04926,hsa04931,hsa04932,hsa04933,hsa05010,hsa05022,hsa05030,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05202,hsa05203,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05235,hsa05321,hsa05418" Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Cellular senescence|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease|Fluid shear stress and atherosclerosis RHD RELB 633.9416932 567.3603863 700.5230002 1.234705519 0.304166996 0.431503886 1 12.64179588 16.28126304 5971 "RELB proto-oncogene, NF-kB subunit" "GO:0000785,GO:0000978,GO:0000981,GO:0002223,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006357,GO:0006954,GO:0007249,GO:0010628,GO:0017053,GO:0019882,GO:0019901,GO:0030098,GO:0032688,GO:0032922,GO:0032991,GO:0033554,GO:0034097,GO:0038061,GO:0042802,GO:0043011,GO:0045063,GO:0045087,GO:0045892,GO:0071470" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|stimulatory C-type lectin receptor signaling pathway|protein binding|nucleus|nucleoplasm|centrosome|cytosol|regulation of transcription by RNA polymerase II|inflammatory response|I-kappaB kinase/NF-kappaB signaling|positive regulation of gene expression|transcription repressor complex|antigen processing and presentation|protein kinase binding|lymphocyte differentiation|negative regulation of interferon-beta production|circadian regulation of gene expression|protein-containing complex|cellular response to stress|response to cytokine|NIK/NF-kappaB signaling|identical protein binding|myeloid dendritic cell differentiation|T-helper 1 cell differentiation|innate immune response|negative regulation of transcription, DNA-templated|cellular response to osmotic stress" "hsa04010,hsa04064,hsa04380,hsa04625,hsa05166,hsa05169" MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection RHD RELCH 1028.645004 1113.406697 943.8833111 0.847743518 -0.238300246 0.497441947 1 5.296339002 4.68334534 57614 "RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing" "GO:0005802,GO:0032367,GO:0055037" trans-Golgi network|intracellular cholesterol transport|recycling endosome RELL1 245.7126244 261.8586398 229.5666091 0.876681438 -0.189875392 0.711530044 1 3.168231325 2.897174306 768211 RELT like 1 "GO:0005515,GO:0005886,GO:0015630,GO:0016021,GO:1900745" protein binding|plasma membrane|microtubule cytoskeleton|integral component of membrane|positive regulation of p38MAPK cascade RELL2 400.4449129 433.3861985 367.5036274 0.847981843 -0.237894721 0.585523823 1 10.16179725 8.988205816 285613 RELT like 2 "GO:0005515,GO:0005518,GO:0005604,GO:0005886,GO:0010811,GO:0016021,GO:1900745" protein binding|collagen binding|basement membrane|plasma membrane|positive regulation of cell-substrate adhesion|integral component of membrane|positive regulation of p38MAPK cascade RELN 63.95979339 95.40586103 32.51372575 0.340793798 -1.553029014 0.051001877 1 0.412706721 0.146706432 5649 reelin "GO:0000904,GO:0001764,GO:0005576,GO:0005615,GO:0005737,GO:0006508,GO:0007155,GO:0007411,GO:0007417,GO:0007420,GO:0008236,GO:0010001,GO:0010976,GO:0018108,GO:0021511,GO:0021766,GO:0021800,GO:0030425,GO:0032793,GO:0038026,GO:0043005,GO:0045860,GO:0046872,GO:0048265,GO:0050731,GO:0050795,GO:0050804,GO:0051057,GO:0051968,GO:0061003,GO:0061098,GO:0070325,GO:0070326,GO:0090129,GO:1900273,GO:2000310,GO:2000463,GO:2000969" "cell morphogenesis involved in differentiation|neuron migration|extracellular region|extracellular space|cytoplasm|proteolysis|cell adhesion|axon guidance|central nervous system development|brain development|serine-type peptidase activity|glial cell differentiation|positive regulation of neuron projection development|peptidyl-tyrosine phosphorylation|spinal cord patterning|hippocampus development|cerebral cortex tangential migration|dendrite|positive regulation of CREB transcription factor activity|reelin-mediated signaling pathway|neuron projection|positive regulation of protein kinase activity|metal ion binding|response to pain|positive regulation of peptidyl-tyrosine phosphorylation|regulation of behavior|modulation of chemical synaptic transmission|positive regulation of small GTPase mediated signal transduction|positive regulation of synaptic transmission, glutamatergic|positive regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|lipoprotein particle receptor binding|very-low-density lipoprotein particle receptor binding|positive regulation of synapse maturation|positive regulation of long-term synaptic potentiation|regulation of NMDA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of AMPA receptor activity" "hsa04151,hsa04510,hsa04512,hsa05017,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Spinocerebellar ataxia|Human papillomavirus infection RELT 641.5753897 685.0952787 598.0555008 0.872952302 -0.196025267 0.612426919 1 9.616867792 8.756692314 84957 RELT TNF receptor "GO:0005515,GO:0005654,GO:0005886,GO:0006915,GO:0016021,GO:0048471,GO:0097186" protein binding|nucleoplasm|plasma membrane|apoptotic process|integral component of membrane|perinuclear region of cytoplasm|amelogenesis hsa04060 Cytokine-cytokine receptor interaction REN 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.105480039 0.07120337 5972 renin "GO:0001822,GO:0001823,GO:0002003,GO:0002018,GO:0004190,GO:0005102,GO:0005159,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0006508,GO:0008217,GO:0008233,GO:0008584,GO:0009755,GO:0032496,GO:0035690,GO:0035902,GO:0042756,GO:0043408,GO:0045177,GO:0048469,GO:0050435,GO:0051591,GO:0070305" kidney development|mesonephros development|angiotensin maturation|renin-angiotensin regulation of aldosterone production|aspartic-type endopeptidase activity|signaling receptor binding|insulin-like growth factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|plasma membrane|proteolysis|regulation of blood pressure|peptidase activity|male gonad development|hormone-mediated signaling pathway|response to lipopolysaccharide|cellular response to drug|response to immobilization stress|drinking behavior|regulation of MAPK cascade|apical part of cell|cell maturation|amyloid-beta metabolic process|response to cAMP|response to cGMP "hsa04614,hsa04924" Renin-angiotensin system|Renin secretion RENBP 5.463491619 3.044867905 7.882115332 2.588655921 1.372203218 0.484534422 1 0.108829794 0.29385837 5973 renin binding protein "GO:0004866,GO:0005515,GO:0005524,GO:0005829,GO:0005975,GO:0006044,GO:0006048,GO:0006051,GO:0008217,GO:0010951,GO:0019262,GO:0030414,GO:0042802,GO:0050121,GO:0070062" endopeptidase inhibitor activity|protein binding|ATP binding|cytosol|carbohydrate metabolic process|N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylmannosamine metabolic process|regulation of blood pressure|negative regulation of endopeptidase activity|N-acetylneuraminate catabolic process|peptidase inhibitor activity|identical protein binding|N-acylglucosamine 2-epimerase activity|extracellular exosome hsa00520 Amino sugar and nucleotide sugar metabolism REP15 7.030462899 9.134603715 4.926322083 0.539303317 -0.890831188 0.625563046 1 0.402291698 0.226302886 387849 RAB15 effector protein "GO:0001881,GO:0005515,GO:0010008,GO:0031901,GO:0033572,GO:0048471,GO:0055037" receptor recycling|protein binding|endosome membrane|early endosome membrane|transferrin transport|perinuclear region of cytoplasm|recycling endosome REPIN1 1754.252661 1784.292592 1724.212729 0.966328469 -0.04941443 0.881043827 1 18.25618691 18.40139626 29803 replication initiator 1 "GO:0003677,GO:0003723,GO:0005654,GO:0005664,GO:0005694,GO:0006260,GO:0006357,GO:0043035,GO:0046872" DNA binding|RNA binding|nucleoplasm|nuclear origin of replication recognition complex|chromosome|DNA replication|regulation of transcription by RNA polymerase II|chromatin insulator sequence binding|metal ion binding zf-C2H2 REPS1 561.9580077 563.3005624 560.615453 0.995233256 -0.0068934 0.991239478 1 6.639326573 6.8923106 85021 RALBP1 associated Eps domain containing 1 "GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005905,GO:0006897,GO:0006898,GO:0016197,GO:0017124,GO:0061024" calcium ion binding|protein binding|cytoplasm|cytosol|plasma membrane|clathrin-coated pit|endocytosis|receptor-mediated endocytosis|endosomal transport|SH3 domain binding|membrane organization REPS2 420.6334309 365.3841486 475.8827132 1.30241751 0.381192001 0.373406687 1 1.897407785 2.577667135 9185 RALBP1 associated Eps domain containing 2 "GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006897,GO:0007173,GO:0016197,GO:0061024,GO:0065003" calcium ion binding|protein binding|cytoplasm|cytosol|plasma membrane|endocytosis|epidermal growth factor receptor signaling pathway|endosomal transport|membrane organization|protein-containing complex assembly RER1 2830.323969 2906.833893 2753.814044 0.947358585 -0.078017491 0.807196906 1 48.61984214 48.04452116 11079 retention in endoplasmic reticulum sorting receptor 1 "GO:0003674,GO:0005515,GO:0005783,GO:0005793,GO:0005794,GO:0005886,GO:0006621,GO:0006890,GO:0009986,GO:0030173,GO:0033130,GO:0071340,GO:1903078" "molecular_function|protein binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|plasma membrane|protein retention in ER lumen|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|cell surface|integral component of Golgi membrane|acetylcholine receptor binding|skeletal muscle acetylcholine-gated channel clustering|positive regulation of protein localization to plasma membrane" RERE 1834.291414 1497.060053 2171.522774 1.450524826 0.536574988 0.098622261 1 8.955919016 13.55037312 473 arginine-glutamic acid dipeptide repeats "GO:0000118,GO:0001085,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0006338,GO:0008270,GO:0021691,GO:0021930,GO:0021942,GO:0043565,GO:0045892,GO:0045893,GO:0048755,GO:0048813" "histone deacetylase complex|RNA polymerase II transcription factor binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|chromatin remodeling|zinc ion binding|cerebellar Purkinje cell layer maturation|cerebellar granule cell precursor proliferation|radial glia guided migration of Purkinje cell|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|branching morphogenesis of a nerve|dendrite morphogenesis" RESF1 878.6299592 759.1870643 998.072854 1.314659984 0.394689718 0.274077298 1 5.740541439 7.871948244 55196 retroelement silencing factor 1 "GO:0000930,GO:0005515,GO:0005634,GO:0042393,GO:0045869,GO:0090309" gamma-tubulin complex|protein binding|nucleus|histone binding|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|positive regulation of DNA methylation-dependent heterochromatin assembly REST 1015.431771 951.0137424 1079.849801 1.135472341 0.183292564 0.603133147 1 5.906252738 6.995270561 5978 RE1 silencing transcription factor "GO:0000122,GO:0000381,GO:0000976,GO:0000978,GO:0001227,GO:0001666,GO:0002931,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0008134,GO:0008285,GO:0010468,GO:0010629,GO:0017053,GO:0032348,GO:0035019,GO:0035690,GO:0043065,GO:0043280,GO:0043922,GO:0045665,GO:0045666,GO:0045667,GO:0045892,GO:0045893,GO:0045944,GO:0045955,GO:0046676,GO:0046872,GO:0050768,GO:0060379,GO:0070933,GO:0071257,GO:0071385,GO:0097150,GO:0099563,GO:1902459,GO:1903203,GO:1903204,GO:1903223,GO:2000065,GO:2000706,GO:2000740,GO:2000798" "negative regulation of transcription by RNA polymerase II|regulation of alternative mRNA splicing, via spliceosome|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|response to hypoxia|response to ischemia|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription factor binding|negative regulation of cell population proliferation|regulation of gene expression|negative regulation of gene expression|transcription repressor complex|negative regulation of aldosterone biosynthetic process|somatic stem cell population maintenance|cellular response to drug|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation by host of viral transcription|negative regulation of neuron differentiation|positive regulation of neuron differentiation|regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of calcium ion-dependent exocytosis|negative regulation of insulin secretion|metal ion binding|negative regulation of neurogenesis|cardiac muscle cell myoblast differentiation|histone H4 deacetylation|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|neuronal stem cell population maintenance|modification of synaptic structure|positive regulation of stem cell population maintenance|regulation of oxidative stress-induced neuron death|negative regulation of oxidative stress-induced neuron death|positive regulation of oxidative stress-induced neuron death|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of mesenchymal stem cell differentiation|negative regulation of amniotic stem cell differentiation" "hsa04550,hsa05016" Signaling pathways regulating pluripotency of stem cells|Huntington disease zf-C2H2 RET 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.007639165 0.030940505 5979 ret proto-oncogene "GO:0000165,GO:0000187,GO:0001657,GO:0001755,GO:0001838,GO:0004713,GO:0004714,GO:0005509,GO:0005515,GO:0005524,GO:0005769,GO:0005886,GO:0005887,GO:0006468,GO:0007156,GO:0007158,GO:0007165,GO:0007169,GO:0007275,GO:0007411,GO:0007497,GO:0010008,GO:0010976,GO:0014042,GO:0018108,GO:0030155,GO:0030335,GO:0030424,GO:0030425,GO:0033141,GO:0033619,GO:0033630,GO:0033674,GO:0035799,GO:0035860,GO:0038023,GO:0042493,GO:0042551,GO:0043025,GO:0043235,GO:0043410,GO:0045121,GO:0045793,GO:0045893,GO:0048265,GO:0048484,GO:0050770,GO:0051897,GO:0060041,GO:0060384,GO:0061146,GO:0071300,GO:0072300,GO:0097021,GO:0098797,GO:2001241" "MAPK cascade|activation of MAPK activity|ureteric bud development|neural crest cell migration|embryonic epithelial tube formation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|calcium ion binding|protein binding|ATP binding|early endosome|plasma membrane|integral component of plasma membrane|protein phosphorylation|homophilic cell adhesion via plasma membrane adhesion molecules|neuron cell-cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|posterior midgut development|endosome membrane|positive regulation of neuron projection development|positive regulation of neuron maturation|peptidyl-tyrosine phosphorylation|regulation of cell adhesion|positive regulation of cell migration|axon|dendrite|positive regulation of peptidyl-serine phosphorylation of STAT protein|membrane protein proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of kinase activity|ureter maturation|glial cell-derived neurotrophic factor receptor signaling pathway|signaling receptor activity|response to drug|neuron maturation|neuronal cell body|receptor complex|positive regulation of MAPK cascade|membrane raft|positive regulation of cell size|positive regulation of transcription, DNA-templated|response to pain|enteric nervous system development|regulation of axonogenesis|positive regulation of protein kinase B signaling|retina development in camera-type eye|innervation|Peyer's patch morphogenesis|cellular response to retinoic acid|positive regulation of metanephric glomerulus development|lymphocyte migration into lymphoid organs|plasma membrane protein complex|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04020,hsa05200,hsa05216,hsa05223,hsa05230" Calcium signaling pathway|Pathways in cancer|Thyroid cancer|Non-small cell lung cancer|Central carbon metabolism in cancer RETREG1 250.7631559 202.9911937 298.5351182 1.470680145 0.556483512 0.267047545 1 2.424142384 3.718709763 54463 reticulophagy regulator 1 "GO:0005515,GO:0005730,GO:0005783,GO:0005801,GO:0016604,GO:0019233,GO:0030176,GO:0043524,GO:0061709" protein binding|nucleolus|endoplasmic reticulum|cis-Golgi network|nuclear body|sensory perception of pain|integral component of endoplasmic reticulum membrane|negative regulation of neuron apoptotic process|reticulophagy RETREG2 2215.855721 1885.788189 2545.923252 1.350057905 0.433021287 0.17670937 1 20.26921034 28.54336397 79137 reticulophagy regulator family member 2 "GO:0005515,GO:0016021" protein binding|integral component of membrane RETREG3 1278.154434 1129.645993 1426.662875 1.262929169 0.336773728 0.320405853 1 14.88360676 19.60663711 162427 reticulophagy regulator family member 3 "GO:0005515,GO:0010976,GO:0016021,GO:0032991,GO:0061709" protein binding|positive regulation of neuron projection development|integral component of membrane|protein-containing complex|reticulophagy RETSAT 1471.506268 1482.85067 1460.161865 0.984699198 -0.022245012 0.948782702 1 23.90995073 24.55829405 54884 retinol saturase "GO:0005640,GO:0005789,GO:0016020,GO:0016491,GO:0031965,GO:0042572,GO:0051786,GO:0055114" "nuclear outer membrane|endoplasmic reticulum membrane|membrane|oxidoreductase activity|nuclear membrane|retinol metabolic process|all-trans-retinol 13,14-reductase activity|oxidation-reduction process" hsa00830 Retinol metabolism REV1 644.7890044 635.3624362 654.2155726 1.029673042 0.042186303 0.91669671 1 5.583700498 5.997046105 51455 REV1 DNA directed polymerase "GO:0003684,GO:0003887,GO:0005515,GO:0005654,GO:0006260,GO:0009411,GO:0017125,GO:0019985,GO:0042276,GO:0046872,GO:0070987" damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleoplasm|DNA replication|response to UV|deoxycytidyl transferase activity|translesion synthesis|error-prone translesion synthesis|metal ion binding|error-free translesion synthesis hsa03460 Fanconi anemia pathway REV3L 844.5235299 886.0565604 802.9904995 0.906251966 -0.142015876 0.697891025 1 3.898161828 3.684891932 5980 "REV3 like, DNA directed polymerase zeta catalytic subunit" "GO:0000166,GO:0000724,GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006261,GO:0008408,GO:0016035,GO:0042276,GO:0046872,GO:0051539,GO:0090305" "nucleotide binding|double-strand break repair via homologous recombination|DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA-dependent DNA replication|3'-5' exonuclease activity|zeta DNA polymerase complex|error-prone translesion synthesis|metal ion binding|4 iron, 4 sulfur cluster binding|nucleic acid phosphodiester bond hydrolysis" "hsa01524,hsa03460" Platinum drug resistance|Fanconi anemia pathway REX1BD 170.8082804 192.841634 148.7749269 0.771487587 -0.37428515 0.512702551 1 12.73370073 10.24706548 55049 required for excision 1-B domain containing GO:0005515 protein binding REXO1 777.2719337 700.3196182 854.2242491 1.219763415 0.28660135 0.438599274 1 6.398830612 8.141269788 57455 RNA exonuclease 1 homolog "GO:0003676,GO:0004527,GO:0005634,GO:0005654,GO:0016604,GO:0090305" nucleic acid binding|exonuclease activity|nucleus|nucleoplasm|nuclear body|nucleic acid phosphodiester bond hydrolysis hsa03008 Ribosome biogenesis in eukaryotes REXO2 1134.308551 1096.152446 1172.464656 1.069618245 0.09709598 0.780282416 1 51.40393925 57.35101834 25996 RNA exonuclease 2 "GO:0000175,GO:0003676,GO:0005634,GO:0005730,GO:0005739,GO:0005758,GO:0005759,GO:0005925,GO:0006139,GO:0008408,GO:0009117,GO:0090503" "3'-5'-exoribonuclease activity|nucleic acid binding|nucleus|nucleolus|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|focal adhesion|nucleobase-containing compound metabolic process|3'-5' exonuclease activity|nucleotide metabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03008 Ribosome biogenesis in eukaryotes REXO4 909.8897127 942.8940946 876.8853307 0.929993449 -0.104707542 0.772360609 1 18.2059701 17.66077038 57109 "REX4 homolog, 3'-5' exonuclease" "GO:0000726,GO:0000737,GO:0000738,GO:0003690,GO:0003697,GO:0003723,GO:0004519,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006355,GO:0006364,GO:0008408,GO:0016607" "non-recombinational repair|DNA catabolic process, endonucleolytic|DNA catabolic process, exonucleolytic|double-stranded DNA binding|single-stranded DNA binding|RNA binding|endonuclease activity|exonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|rRNA processing|3'-5' exonuclease activity|nuclear speck" REXO5 166.3921579 160.363043 172.4212729 1.075193322 0.104596082 0.864621849 1 2.843775351 3.189317629 81691 RNA exonuclease 5 "GO:0003723,GO:0004527,GO:0005634,GO:0005730,GO:0070062,GO:0090305" RNA binding|exonuclease activity|nucleus|nucleolus|extracellular exosome|nucleic acid phosphodiester bond hydrolysis hsa03008 Ribosome biogenesis in eukaryotes RFC1 1398.046169 1276.814608 1519.27773 1.189896889 0.250836562 0.453781286 1 13.27029665 16.47046613 5981 replication factor C subunit 1 "GO:0000122,GO:0003677,GO:0003689,GO:0003690,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0005730,GO:0005737,GO:0006261,GO:0006283,GO:0006296,GO:0006297,GO:0007004,GO:0008047,GO:0019904,GO:0019985,GO:0031391,GO:0032201,GO:0033683,GO:0042276,GO:0042769,GO:0043565,GO:0045893,GO:0050790,GO:0061860,GO:0070062,GO:0070987,GO:0090618" "negative regulation of transcription by RNA polymerase II|DNA binding|DNA clamp loader activity|double-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor C complex|nucleolus|cytoplasm|DNA-dependent DNA replication|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|telomere maintenance via telomerase|enzyme activator activity|protein domain specific binding|translesion synthesis|Elg1 RFC-like complex|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|error-prone translesion synthesis|DNA damage response, detection of DNA damage|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|regulation of catalytic activity|DNA clamp unloader activity|extracellular exosome|error-free translesion synthesis|DNA clamp unloading" "hsa03030,hsa03420,hsa03430" DNA replication|Nucleotide excision repair|Mismatch repair RFC2 1173.426171 1210.84247 1136.009872 0.938197908 -0.092035811 0.790433608 1 36.09470249 35.32269703 5982 replication factor C subunit 2 "GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0006260,GO:0006261,GO:0006281,GO:0006283,GO:0006296,GO:0006297,GO:0017116,GO:0019899,GO:0019985,GO:0031390,GO:0032201,GO:0032508,GO:0033683,GO:0042276,GO:0042769,GO:0070987,GO:1900264,GO:1901796" "DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor C complex|DNA replication|DNA-dependent DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|single-stranded DNA helicase activity|enzyme binding|translesion synthesis|Ctf18 RFC-like complex|telomere maintenance via semi-conservative replication|DNA duplex unwinding|nucleotide-excision repair, DNA incision|error-prone translesion synthesis|DNA damage response, detection of DNA damage|error-free translesion synthesis|positive regulation of DNA-directed DNA polymerase activity|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430" DNA replication|Nucleotide excision repair|Mismatch repair RFC3 872.1581925 855.6078813 888.7085037 1.038686673 0.054760521 0.882473481 1 3.853581217 4.175081962 5983 replication factor C subunit 3 "GO:0000731,GO:0003677,GO:0003689,GO:0005515,GO:0005634,GO:0005654,GO:0005663,GO:0006260,GO:0006261,GO:0006271,GO:0006281,GO:0006283,GO:0006296,GO:0006297,GO:0016887,GO:0017116,GO:0019985,GO:0031390,GO:0032201,GO:0032508,GO:0033683,GO:0042276,GO:0042769,GO:0046683,GO:0070987,GO:1900264,GO:1901796" "DNA synthesis involved in DNA repair|DNA binding|DNA clamp loader activity|protein binding|nucleus|nucleoplasm|DNA replication factor C complex|DNA replication|DNA-dependent DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|ATPase activity|single-stranded DNA helicase activity|translesion synthesis|Ctf18 RFC-like complex|telomere maintenance via semi-conservative replication|DNA duplex unwinding|nucleotide-excision repair, DNA incision|error-prone translesion synthesis|DNA damage response, detection of DNA damage|response to organophosphorus|error-free translesion synthesis|positive regulation of DNA-directed DNA polymerase activity|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430" DNA replication|Nucleotide excision repair|Mismatch repair RFC4 760.9611309 629.2727004 892.6495614 1.418541692 0.504408554 0.174320907 1 23.3483094 34.54724932 5984 replication factor C subunit 4 "GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0006260,GO:0006261,GO:0006271,GO:0006281,GO:0006283,GO:0006296,GO:0006297,GO:0017116,GO:0019985,GO:0031390,GO:0031391,GO:0032201,GO:0032508,GO:0033683,GO:0042276,GO:0042769,GO:0070987,GO:1900264,GO:1901796" "DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor C complex|DNA replication|DNA-dependent DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|single-stranded DNA helicase activity|translesion synthesis|Ctf18 RFC-like complex|Elg1 RFC-like complex|telomere maintenance via semi-conservative replication|DNA duplex unwinding|nucleotide-excision repair, DNA incision|error-prone translesion synthesis|DNA damage response, detection of DNA damage|error-free translesion synthesis|positive regulation of DNA-directed DNA polymerase activity|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430" DNA replication|Nucleotide excision repair|Mismatch repair RFC5 953.5679541 965.2231259 941.9127822 0.975849787 -0.035269004 0.923917488 1 23.60460948 24.02678827 5985 replication factor C subunit 5 "GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0006260,GO:0006261,GO:0006281,GO:0006283,GO:0006296,GO:0006297,GO:0017116,GO:0019899,GO:0019985,GO:0031390,GO:0032201,GO:0032508,GO:0033683,GO:0042276,GO:0042769,GO:0070987,GO:1900264,GO:1901796" "DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor C complex|DNA replication|DNA-dependent DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|single-stranded DNA helicase activity|enzyme binding|translesion synthesis|Ctf18 RFC-like complex|telomere maintenance via semi-conservative replication|DNA duplex unwinding|nucleotide-excision repair, DNA incision|error-prone translesion synthesis|DNA damage response, detection of DNA damage|error-free translesion synthesis|positive regulation of DNA-directed DNA polymerase activity|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430" DNA replication|Nucleotide excision repair|Mismatch repair RFESD 26.55488032 30.44867905 22.66108158 0.744238577 -0.426162921 0.69944254 1 0.397350729 0.30846232 317671 Rieske Fe-S domain containing "GO:0005515,GO:0046872,GO:0051537,GO:0055114" "protein binding|metal ion binding|2 iron, 2 sulfur cluster binding|oxidation-reduction process" RFFL 658.6069546 704.3794421 612.8344671 0.870034573 -0.200855364 0.601415165 1 4.94789651 4.49027612 117584 ring finger and FYVE like domain containing E3 ubiquitin protein ligase "GO:0000139,GO:0002020,GO:0002039,GO:0005515,GO:0005654,GO:0005737,GO:0005764,GO:0005829,GO:0005886,GO:0006511,GO:0006915,GO:0010008,GO:0010762,GO:0010804,GO:0016020,GO:0019901,GO:0031625,GO:0032006,GO:0043161,GO:0046872,GO:0055038,GO:0061630,GO:0070936,GO:1901797,GO:1902042,GO:2001271" Golgi membrane|protease binding|p53 binding|protein binding|nucleoplasm|cytoplasm|lysosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|endosome membrane|regulation of fibroblast migration|negative regulation of tumor necrosis factor-mediated signaling pathway|membrane|protein kinase binding|ubiquitin protein ligase binding|regulation of TOR signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|recycling endosome membrane|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of signal transduction by p53 class mediator|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis RFK 254.1319093 264.9035077 243.3603109 0.918675305 -0.122373046 0.812580656 1 5.168115618 4.952337032 55312 riboflavin kinase "GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006771,GO:0006915,GO:0008531,GO:0009231,GO:0009398,GO:0016310,GO:0033864,GO:0046872,GO:0072593" protein binding|ATP binding|cytoplasm|mitochondrion|cytosol|riboflavin metabolic process|apoptotic process|riboflavin kinase activity|riboflavin biosynthetic process|FMN biosynthetic process|phosphorylation|positive regulation of NAD(P)H oxidase activity|metal ion binding|reactive oxygen species metabolic process hsa00740 Riboflavin metabolism RFLNB 641.6320512 722.6486495 560.615453 0.775778732 -0.36628287 0.341750228 1 10.10480529 8.176769368 359845 refilin B "GO:0001837,GO:0005737,GO:0031005,GO:0032432,GO:0048705,GO:0061182,GO:0061572,GO:1900158" epithelial to mesenchymal transition|cytoplasm|filamin binding|actin filament bundle|skeletal system morphogenesis|negative regulation of chondrocyte development|actin filament bundle organization|negative regulation of bone mineralization involved in bone maturation RFNG 526.9447484 459.7750537 594.1144432 1.292185034 0.369812671 0.35970029 1 12.3664283 16.66805481 5986 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase "GO:0003674,GO:0005576,GO:0007389,GO:0007399,GO:0008375,GO:0008593,GO:0009887,GO:0030154,GO:0030173,GO:0032092,GO:0033829,GO:0045747,GO:0046872" molecular_function|extracellular region|pattern specification process|nervous system development|acetylglucosaminyltransferase activity|regulation of Notch signaling pathway|animal organ morphogenesis|cell differentiation|integral component of Golgi membrane|positive regulation of protein binding|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|positive regulation of Notch signaling pathway|metal ion binding "hsa00514,hsa04330,hsa05165" Other types of O-glycan biosynthesis|Notch signaling pathway|Human papillomavirus infection RFT1 816.3126037 843.4284097 789.1967977 0.93570099 -0.095880516 0.795856178 1 3.708688446 3.619706601 91869 RFT1 homolog "GO:0005515,GO:0005789,GO:0006488,GO:0008643,GO:0016021,GO:0034203" protein binding|endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|carbohydrate transport|integral component of membrane|glycolipid translocation RFTN1 1133.135734 1015.970924 1250.300545 1.230645991 0.299415814 0.385949575 1 11.46764947 14.72053114 23180 "raftlin, lipid raft linker 1" "GO:0001765,GO:0002457,GO:0003725,GO:0005737,GO:0005768,GO:0005769,GO:0005886,GO:0032596,GO:0032620,GO:0032991,GO:0033227,GO:0034138,GO:0040010,GO:0043330,GO:0045121,GO:0050852,GO:0050853,GO:0070062,GO:1903044" membrane raft assembly|T cell antigen processing and presentation|double-stranded RNA binding|cytoplasm|endosome|early endosome|plasma membrane|protein transport into membrane raft|interleukin-17 production|protein-containing complex|dsRNA transport|toll-like receptor 3 signaling pathway|positive regulation of growth rate|response to exogenous dsRNA|membrane raft|T cell receptor signaling pathway|B cell receptor signaling pathway|extracellular exosome|protein localization to membrane raft RFWD3 1661.137255 1514.314305 1807.960204 1.193913442 0.255698246 0.435403792 1 11.98916326 14.93061324 55159 ring finger and WD repeat domain 3 "GO:0000724,GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006974,GO:0010212,GO:0016567,GO:0016605,GO:0031052,GO:0031297,GO:0031571,GO:0035861,GO:0036297,GO:0046872,GO:0061630,GO:0090734,GO:0097371,GO:2000001" double-strand break repair via homologous recombination|p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|cellular response to DNA damage stimulus|response to ionizing radiation|protein ubiquitination|PML body|chromosome breakage|replication fork processing|mitotic G1 DNA damage checkpoint|site of double-strand break|interstrand cross-link repair|metal ion binding|ubiquitin protein ligase activity|site of DNA damage|MDM2/MDM4 family protein binding|regulation of DNA damage checkpoint RFX1 403.3170747 360.3093688 446.3247807 1.238726548 0.308857744 0.476744728 1 3.26155468 4.214208697 5989 regulatory factor X1 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0006357,GO:0006955,GO:0043231,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|immune response|intracellular membrane-bounded organelle|sequence-specific double-stranded DNA binding" RFX2 86.09855121 93.37594909 78.82115332 0.844126931 -0.244468142 0.742588179 1 1.193328895 1.050712364 5990 regulatory factor X2 "GO:0000785,GO:0000978,GO:0000981,GO:0001675,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0007286,GO:0060271,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|acrosome assembly|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|spermatid development|cilium assembly|sequence-specific double-stranded DNA binding" RFX RFX3 224.2352456 208.0659735 240.4045176 1.155424472 0.208422957 0.693366177 1 0.621369629 0.748871864 5991 regulatory factor X3 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005576,GO:0005634,GO:0005667,GO:0006351,GO:0006355,GO:0006357,GO:0031018,GO:0045892,GO:0045893,GO:0045944,GO:0048469,GO:0050796,GO:0060271,GO:0060285,GO:0060287,GO:0072560,GO:1990837,GO:2000078" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|extracellular region|nucleus|transcription regulator complex|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|endocrine pancreas development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell maturation|regulation of insulin secretion|cilium assembly|cilium-dependent cell motility|epithelial cilium movement involved in determination of left/right asymmetry|type B pancreatic cell maturation|sequence-specific double-stranded DNA binding|positive regulation of type B pancreatic cell development" RFX RFX5 1317.975249 1225.051854 1410.898644 1.151705244 0.203771535 0.546449449 1 16.07788408 19.31461996 5993 regulatory factor X5 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0006357,GO:0043565,GO:0045944,GO:0090575,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa04612,hsa05152,hsa05340" Antigen processing and presentation|Tuberculosis|Primary immunodeficiency RFX RFX7 673.8555424 803.845127 543.8659579 0.676580525 -0.563666445 0.139103017 1 2.644833358 1.866524678 64864 regulatory factor X7 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" RFX8 57.112923 31.46363502 82.76221099 2.630408436 1.395286831 0.089631549 1 0.445491226 1.2223013 731220 regulatory factor X8 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II" RFXANK 655.0276387 661.7512914 648.3039861 0.979679216 -0.029618662 0.942573676 1 21.14534283 21.60799919 8625 regulatory factor X associated ankyrin containing protein "GO:0000977,GO:0001228,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007265,GO:0010468,GO:0042826,GO:0045171,GO:0045944,GO:0090575" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|Ras protein signal transduction|regulation of gene expression|histone deacetylase binding|intercellular bridge|positive regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulator complex" "hsa04612,hsa05152,hsa05340" Antigen processing and presentation|Tuberculosis|Primary immunodeficiency RFXAP 118.6419685 95.40586103 141.878076 1.48710021 0.572501869 0.373311084 1 2.095390412 3.250282556 5994 regulatory factor X associated protein "GO:0000977,GO:0001228,GO:0005634,GO:0006357,GO:0016607,GO:0045944,GO:0090575" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|nuclear speck|positive regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulator complex" "hsa04612,hsa05152,hsa05340" Antigen processing and presentation|Tuberculosis|Primary immunodeficiency RGCC 11.94193921 8.119647747 15.76423066 1.941491941 0.957165719 0.487279695 1 0.429260453 0.869305448 28984 regulator of cell cycle "GO:0001100,GO:0001818,GO:0001819,GO:0001937,GO:0003331,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0006956,GO:0006977,GO:0008285,GO:0010628,GO:0010718,GO:0016525,GO:0019901,GO:0030295,GO:0032147,GO:0032967,GO:0043537,GO:0045737,GO:0045840,GO:0045944,GO:0051091,GO:0051496,GO:0070412,GO:0071158,GO:0071456,GO:0071850,GO:0072537,GO:0090272,GO:1900087,GO:1901203,GO:1901991,GO:2000048,GO:2000353,GO:2000573" "negative regulation of exit from mitosis|negative regulation of cytokine production|positive regulation of cytokine production|negative regulation of endothelial cell proliferation|positive regulation of extracellular matrix constituent secretion|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|complement activation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell population proliferation|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of angiogenesis|protein kinase binding|protein kinase activator activity|activation of protein kinase activity|positive regulation of collagen biosynthetic process|negative regulation of blood vessel endothelial cell migration|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|positive regulation of stress fiber assembly|R-SMAD binding|positive regulation of cell cycle arrest|cellular response to hypoxia|mitotic cell cycle arrest|fibroblast activation|negative regulation of fibroblast growth factor production|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of extracellular matrix assembly|negative regulation of mitotic cell cycle phase transition|negative regulation of cell-cell adhesion mediated by cadherin|positive regulation of endothelial cell apoptotic process|positive regulation of DNA biosynthetic process" RGL1 212.248769 196.9014579 227.5960802 1.155888243 0.209001918 0.698069893 1 1.902033991 2.29324286 23179 ral guanine nucleotide dissociation stimulator like 1 "GO:0005085,GO:0005515,GO:0005575,GO:0005829,GO:0007264,GO:0019216,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|cellular_component|cytosol|small GTPase mediated signal transduction|regulation of lipid metabolic process|regulation of catalytic activity hsa04014 Ras signaling pathway RGL2 1457.749184 1215.91725 1699.581119 1.397776961 0.483134173 0.14678269 1 21.19859526 30.9072874 5863 ral guanine nucleotide dissociation stimulator like 2 "GO:0005085,GO:0005515,GO:0005575,GO:0007265,GO:0010667,GO:0014068,GO:0032485,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|cellular_component|Ras protein signal transduction|negative regulation of cardiac muscle cell apoptotic process|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of Ral protein signal transduction|regulation of catalytic activity hsa04014 Ras signaling pathway RGL3 202.962986 201.9762377 203.9497342 1.009770934 0.014028056 0.989556272 1 4.044833496 4.260292759 57139 ral guanine nucleotide dissociation stimulator like 3 "GO:0005085,GO:0005515,GO:0007264,GO:0031267,GO:0043547" guanyl-nucleotide exchange factor activity|protein binding|small GTPase mediated signal transduction|small GTPase binding|positive regulation of GTPase activity RGMB 1258.204932 1011.9111 1504.498764 1.486789465 0.572200371 0.092428364 1 8.407107518 13.03803092 285704 repulsive guidance molecule BMP co-receptor b "GO:0005515,GO:0005793,GO:0005886,GO:0007155,GO:0007165,GO:0015026,GO:0030509,GO:0042802,GO:0045121,GO:0045893,GO:0046658" "protein binding|endoplasmic reticulum-Golgi intermediate compartment|plasma membrane|cell adhesion|signal transduction|coreceptor activity|BMP signaling pathway|identical protein binding|membrane raft|positive regulation of transcription, DNA-templated|anchored component of plasma membrane" hsa04350 TGF-beta signaling pathway RGP1 3717.414037 3166.662621 4268.165452 1.347843444 0.430652933 0.176480548 1 22.82018931 32.08297427 9827 "RGP1 homolog, RAB6A GEF complex partner 1" "GO:0000139,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0016020,GO:0031267,GO:0032588,GO:0032991,GO:0034066,GO:0042147,GO:0043547,GO:1903363" "Golgi membrane|guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|membrane|small GTPase binding|trans-Golgi network membrane|protein-containing complex|RIC1-RGP1 guanyl-nucleotide exchange factor complex|retrograde transport, endosome to Golgi|positive regulation of GTPase activity|negative regulation of cellular protein catabolic process" RGPD1 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.008311737 0.012624221 400966 RANBP2 like and GRIP domain containing 1 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|positive regulation of GTPase activity RGPD2 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.025411851 0.008577023 729857 RANBP2 like and GRIP domain containing 2 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|positive regulation of GTPase activity RGPD3 14.41994602 9.134603715 19.70528833 2.157213268 1.109168812 0.380689838 1 0.053403608 0.120165448 653489 RANBP2 like and GRIP domain containing 3 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|positive regulation of GTPase activity RGPD4 30.01815155 31.46363502 28.57266808 0.908117198 -0.139049597 0.922111617 1 0.194024366 0.18378671 285190 RANBP2 like and GRIP domain containing 4 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|positive regulation of GTPase activity RGPD5 31.88475995 24.35894324 39.41057666 1.617909951 0.694131313 0.48341384 1 0.120442697 0.20325945 84220 RANBP2 like and GRIP domain containing 5 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|positive regulation of GTPase activity RGPD6 10.98636634 10.14955968 11.823173 1.164895165 0.220200125 0.941332157 1 0.044097057 0.053581193 729540 RANBP2 like and GRIP domain containing 6 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|positive regulation of GTPase activity RGPD8 114.2973533 101.4955968 127.0991097 1.252262302 0.324536784 0.623236133 1 0.362433471 0.473412298 727851 RANBP2 like and GRIP domain containing 8 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0008150,GO:0031267,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|biological_process|small GTPase binding|positive regulation of GTPase activity RGS10 461.3477142 488.1938208 434.5016077 0.890018655 -0.168092519 0.689998794 1 23.63794912 21.94445669 6001 regulator of G protein signaling 10 "GO:0001965,GO:0001975,GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0007186,GO:0007213,GO:0008277,GO:0009968,GO:0043025,GO:0043197,GO:0043547,GO:0043679" G-protein alpha-subunit binding|response to amphetamine|GTPase activity|GTPase activator activity|protein binding|nucleus|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|neuronal cell body|dendritic spine|positive regulation of GTPase activity|axon terminus RGS11 31.7956853 18.26920743 45.32216316 2.480795258 1.310802673 0.180815807 1 0.311015431 0.804801523 8786 regulator of G protein signaling 11 "GO:0003924,GO:0005096,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0031681,GO:0032991,GO:0035556,GO:0043547" GTPase activity|GTPase activator activity|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|G-protein beta-subunit binding|protein-containing complex|intracellular signal transduction|positive regulation of GTPase activity RGS12 344.7762356 264.9035077 424.6489635 1.603032618 0.680803781 0.133329382 1 1.058745908 1.770312899 6002 regulator of G protein signaling 12 "GO:0000794,GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0016363,GO:0030425,GO:0030695,GO:0043547,GO:0045202" condensed nuclear chromosome|GTPase activity|GTPase activator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|nuclear matrix|dendrite|GTPase regulator activity|positive regulation of GTPase activity|synapse RGS14 315.4558356 281.1428032 349.7688679 1.244096821 0.315098767 0.500437354 1 5.523231642 7.167428478 10636 regulator of G protein signaling 14 "GO:0000278,GO:0000922,GO:0001965,GO:0003924,GO:0005092,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005874,GO:0005886,GO:0006913,GO:0006979,GO:0007051,GO:0007059,GO:0007186,GO:0007612,GO:0007616,GO:0008017,GO:0008277,GO:0008542,GO:0010070,GO:0014069,GO:0016604,GO:0016605,GO:0019901,GO:0030159,GO:0030425,GO:0031914,GO:0032794,GO:0035556,GO:0043197,GO:0043407,GO:0043547,GO:0043620,GO:0045744,GO:0048008,GO:0050769,GO:0051301,GO:0060291,GO:0070373,GO:0098978" mitotic cell cycle|spindle pole|G-protein alpha-subunit binding|GTPase activity|GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|nucleus|cytoplasm|centrosome|spindle|microtubule|plasma membrane|nucleocytoplasmic transport|response to oxidative stress|spindle organization|chromosome segregation|G protein-coupled receptor signaling pathway|learning|long-term memory|microtubule binding|regulation of G protein-coupled receptor signaling pathway|visual learning|zygote asymmetric cell division|postsynaptic density|nuclear body|PML body|protein kinase binding|signaling receptor complex adaptor activity|dendrite|negative regulation of synaptic plasticity|GTPase activating protein binding|intracellular signal transduction|dendritic spine|negative regulation of MAP kinase activity|positive regulation of GTPase activity|regulation of DNA-templated transcription in response to stress|negative regulation of G protein-coupled receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|cell division|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|glutamatergic synapse hsa04015 Rap1 signaling pathway RGS17 178.1235347 187.7668541 168.4802152 0.897284113 -0.156363227 0.787721291 1 1.125944679 1.053811567 26575 regulator of G protein signaling 17 "GO:0001975,GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0007186,GO:0009968,GO:0043005,GO:0043547,GO:0045202" response to amphetamine|GTPase activity|GTPase activator activity|protein binding|nucleus|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|negative regulation of signal transduction|neuron projection|positive regulation of GTPase activity|synapse RGS19 453.7261419 404.9674314 502.4848524 1.24080312 0.311274219 0.458662755 1 8.936894013 11.56659193 10287 regulator of G protein signaling 19 "GO:0001965,GO:0003924,GO:0005515,GO:0005794,GO:0005886,GO:0005903,GO:0006914,GO:0007186,GO:0007264,GO:0009968,GO:0016020,GO:0030136,GO:0045121,GO:0045471" G-protein alpha-subunit binding|GTPase activity|protein binding|Golgi apparatus|plasma membrane|brush border|autophagy|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|negative regulation of signal transduction|membrane|clathrin-coated vesicle|membrane raft|response to ethanol RGS2 84.60580881 92.36099312 76.85062449 0.832067975 -0.265226703 0.721880468 1 3.470147234 3.011775793 5997 regulator of G protein signaling 2 "GO:0001965,GO:0001975,GO:0003924,GO:0005096,GO:0005515,GO:0005516,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0007049,GO:0007186,GO:0007283,GO:0007420,GO:0008277,GO:0009898,GO:0010519,GO:0010614,GO:0010976,GO:0017148,GO:0030728,GO:0043005,GO:0043407,GO:0043547,GO:0043951,GO:0045471,GO:0045744,GO:0048487,GO:0050873,GO:0055119,GO:0060087,GO:0060135,GO:0060452,GO:0061052,GO:0140194,GO:1900924" G-protein alpha-subunit binding|response to amphetamine|GTPase activity|GTPase activator activity|protein binding|calmodulin binding|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|plasma membrane|cell cycle|G protein-coupled receptor signaling pathway|spermatogenesis|brain development|regulation of G protein-coupled receptor signaling pathway|cytoplasmic side of plasma membrane|negative regulation of phospholipase activity|negative regulation of cardiac muscle hypertrophy|positive regulation of neuron projection development|negative regulation of translation|ovulation|neuron projection|negative regulation of MAP kinase activity|positive regulation of GTPase activity|negative regulation of cAMP-mediated signaling|response to ethanol|negative regulation of G protein-coupled receptor signaling pathway|beta-tubulin binding|brown fat cell differentiation|relaxation of cardiac muscle|relaxation of vascular associated smooth muscle|maternal process involved in female pregnancy|positive regulation of cardiac muscle contraction|negative regulation of cell growth involved in cardiac muscle cell development|negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process|negative regulation of glycine import across plasma membrane "hsa04022,hsa04740,hsa04921" cGMP-PKG signaling pathway|Olfactory transduction|Oxytocin signaling pathway RGS20 441.2591573 428.3114187 454.206896 1.060459461 0.08468947 0.845674286 1 9.30607566 10.29382024 8601 regulator of G protein signaling 20 "GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005802,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0043547" GTPase activity|GTPase activator activity|protein binding|nucleus|cytoplasm|trans-Golgi network|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|positive regulation of GTPase activity RGS3 781.0887819 759.1870643 802.9904995 1.057697815 0.080927508 0.829365907 1 5.401060059 5.958768917 5998 regulator of G protein signaling 3 "GO:0000188,GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0007165,GO:0007186,GO:0008277,GO:0043547" inactivation of MAPK activity|GTPase activity|GTPase activator activity|protein binding|nucleus|cytosol|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|positive regulation of GTPase activity hsa04360 Axon guidance RGS4 6.567522243 11.16451565 1.970528833 0.176499267 -2.5022659 0.161860904 1 0.163706813 0.030138775 5999 regulator of G protein signaling 4 "GO:0000188,GO:0001965,GO:0001975,GO:0003924,GO:0005096,GO:0005516,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0007420,GO:0008277,GO:0010460,GO:0032991,GO:0042220,GO:0043278,GO:0043547,GO:0045471,GO:0045744,GO:0051924,GO:0060160,GO:0061052,GO:0110053,GO:1900924,GO:1901380,GO:1990791,GO:2000463" inactivation of MAPK activity|G-protein alpha-subunit binding|response to amphetamine|GTPase activity|GTPase activator activity|calmodulin binding|nucleus|cytoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|brain development|regulation of G protein-coupled receptor signaling pathway|positive regulation of heart rate|protein-containing complex|response to cocaine|response to morphine|positive regulation of GTPase activity|response to ethanol|negative regulation of G protein-coupled receptor signaling pathway|regulation of calcium ion transport|negative regulation of dopamine receptor signaling pathway|negative regulation of cell growth involved in cardiac muscle cell development|regulation of actin filament organization|negative regulation of glycine import across plasma membrane|negative regulation of potassium ion transmembrane transport|dorsal root ganglion development|positive regulation of excitatory postsynaptic potential RGS5 39.55631282 43.64310664 35.469519 0.812717557 -0.299174035 0.762417238 1 0.375083894 0.317968419 8490 regulator of G protein signaling 5 "GO:0003924,GO:0005096,GO:0005515,GO:0005737,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0043547" GTPase activity|GTPase activator activity|protein binding|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|positive regulation of GTPase activity RGS9 162.5819907 202.9911937 122.1727877 0.601862502 -0.732494161 0.204702188 1 2.000153278 1.255672821 8787 regulator of G protein signaling 9 "GO:0001975,GO:0003924,GO:0005096,GO:0005634,GO:0005737,GO:0005886,GO:0006457,GO:0007186,GO:0007212,GO:0007399,GO:0007601,GO:0008277,GO:0009968,GO:0032355,GO:0035556,GO:0043547,GO:0098839,GO:0098978,GO:1904783,GO:1905912" response to amphetamine|GTPase activity|GTPase activator activity|nucleus|cytoplasm|plasma membrane|protein folding|G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|nervous system development|visual perception|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|response to estradiol|intracellular signal transduction|positive regulation of GTPase activity|postsynaptic density membrane|glutamatergic synapse|positive regulation of NMDA glutamate receptor activity|regulation of calcium ion export across plasma membrane "hsa04744,hsa05030" Phototransduction|Cocaine addiction RGS9BP 14.50902068 15.22433953 13.79370183 0.906029572 -0.142369955 0.969242346 1 0.314333098 0.297062899 388531 regulator of G protein signaling 9 binding protein "GO:0001750,GO:0009968,GO:0016021,GO:0050908" photoreceptor outer segment|negative regulation of signal transduction|integral component of membrane|detection of light stimulus involved in visual perception RHBDD1 413.4908828 449.625494 377.3562715 0.839267961 -0.252796588 0.558302152 1 2.485206274 2.175599825 84236 rhomboid domain containing 1 "GO:0004252,GO:0005515,GO:0005783,GO:0005789,GO:0006915,GO:0010954,GO:0030176,GO:0031293,GO:0031966,GO:0034620,GO:0034644,GO:0036503,GO:0043066,GO:0043687,GO:0044322,GO:0048515,GO:1904211,GO:2000254" "serine-type endopeptidase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|apoptotic process|positive regulation of protein processing|integral component of endoplasmic reticulum membrane|membrane protein intracellular domain proteolysis|mitochondrial membrane|cellular response to unfolded protein|cellular response to UV|ERAD pathway|negative regulation of apoptotic process|post-translational protein modification|endoplasmic reticulum quality control compartment|spermatid differentiation|membrane protein proteolysis involved in retrograde protein transport, ER to cytosol|regulation of male germ cell proliferation" RHBDD2 1461.812968 1359.026042 1564.599893 1.151265572 0.203220671 0.541792539 1 24.00762981 28.82974048 57414 rhomboid domain containing 2 "GO:0000139,GO:0000839,GO:0004252,GO:0005654,GO:0005794,GO:0030176,GO:0030433,GO:0030968,GO:0048471,GO:0051787,GO:1990381" Golgi membrane|Hrd1p ubiquitin ligase ERAD-L complex|serine-type endopeptidase activity|nucleoplasm|Golgi apparatus|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|perinuclear region of cytoplasm|misfolded protein binding|ubiquitin-specific protease binding RHBDD3 330.8556028 357.2645009 304.4467047 0.852160525 -0.230802872 0.617909512 1 9.414249019 8.368026059 25807 rhomboid domain containing 3 "GO:0000165,GO:0001889,GO:0002673,GO:0004252,GO:0006508,GO:0009410,GO:0016021,GO:0032815,GO:0045732,GO:0050708" MAPK cascade|liver development|regulation of acute inflammatory response|serine-type endopeptidase activity|proteolysis|response to xenobiotic stimulus|integral component of membrane|negative regulation of natural killer cell activation|positive regulation of protein catabolic process|regulation of protein secretion RHBDF1 829.7109128 749.0375047 910.3843209 1.215405524 0.281437754 0.440927286 1 11.1119236 14.0872552 64285 rhomboid 5 homolog 1 "GO:0000139,GO:0004252,GO:0005515,GO:0005789,GO:0006508,GO:0008283,GO:0015031,GO:0016021,GO:0016477,GO:0019838,GO:0042058,GO:0050708,GO:0050709,GO:0061136" Golgi membrane|serine-type endopeptidase activity|protein binding|endoplasmic reticulum membrane|proteolysis|cell population proliferation|protein transport|integral component of membrane|cell migration|growth factor binding|regulation of epidermal growth factor receptor signaling pathway|regulation of protein secretion|negative regulation of protein secretion|regulation of proteasomal protein catabolic process RHBDF2 301.0128789 371.4738844 230.5518735 0.620640866 -0.6881694 0.145545926 1 3.218792432 2.083767546 79651 rhomboid 5 homolog 2 "GO:0004252,GO:0005515,GO:0005789,GO:0005886,GO:0006508,GO:0015031,GO:0016021,GO:0019838,GO:0042058,GO:0050708,GO:0050709" serine-type endopeptidase activity|protein binding|endoplasmic reticulum membrane|plasma membrane|proteolysis|protein transport|integral component of membrane|growth factor binding|regulation of epidermal growth factor receptor signaling pathway|regulation of protein secretion|negative regulation of protein secretion RHBDL1 7.030462899 9.134603715 4.926322083 0.539303317 -0.890831188 0.625563046 1 0.255036082 0.143466548 9028 rhomboid like 1 "GO:0004252,GO:0005515,GO:0005887,GO:0006508,GO:0007165,GO:0016020" serine-type endopeptidase activity|protein binding|integral component of plasma membrane|proteolysis|signal transduction|membrane RHBDL2 19.86859187 11.16451565 28.57266808 2.559239377 1.355715095 0.230474421 1 0.281595285 0.751713271 54933 rhomboid like 2 "GO:0004252,GO:0005886,GO:0006508,GO:0016021" serine-type endopeptidase activity|plasma membrane|proteolysis|integral component of membrane RHBDL3 18.33131214 7.104691779 29.5579325 4.160339874 2.056701392 0.082494374 1 0.049036192 0.212795027 162494 rhomboid like 3 "GO:0004252,GO:0005509,GO:0006508,GO:0016021" serine-type endopeptidase activity|calcium ion binding|proteolysis|integral component of membrane RHCE 6.552676467 10.14955968 2.95579325 0.291223791 -1.779799875 0.306941875 1 0.119627506 0.036339072 6006 Rh blood group CcEe antigens "GO:0005887,GO:0008519,GO:0072488" integral component of plasma membrane|ammonium transmembrane transporter activity|ammonium transmembrane transport RHEB 1345.667811 1400.639236 1290.696386 0.921505233 -0.117935736 0.727191757 1 26.56832815 25.53747545 6009 "Ras homolog, mTORC1 binding" "GO:0000139,GO:0000287,GO:0003924,GO:0005515,GO:0005525,GO:0005681,GO:0005765,GO:0005789,GO:0005829,GO:0005886,GO:0007050,GO:0007165,GO:0007264,GO:0014069,GO:0016020,GO:0016241,GO:0019003,GO:0019901,GO:0032008,GO:0048714,GO:0070062,GO:0120163,GO:2000074" Golgi membrane|magnesium ion binding|GTPase activity|protein binding|GTP binding|spliceosomal complex|lysosomal membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|cell cycle arrest|signal transduction|small GTPase mediated signal transduction|postsynaptic density|membrane|regulation of macroautophagy|GDP binding|protein kinase binding|positive regulation of TOR signaling|positive regulation of oligodendrocyte differentiation|extracellular exosome|negative regulation of cold-induced thermogenesis|regulation of type B pancreatic cell development "hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04714,hsa04910,hsa04919,hsa05163,hsa05165,hsa05168,hsa05231" Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Thermogenesis|Insulin signaling pathway|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Choline metabolism in cancer RHEBL1 203.5946734 144.1237475 263.0655992 1.825275874 0.868114531 0.106164743 1 5.881836723 11.19843691 121268 RHEB like 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005886,GO:0007264,GO:0012505,GO:0019003,GO:0031929,GO:0046872,GO:0051092" GTPase activity|protein binding|GTP binding|cytoplasm|plasma membrane|small GTPase mediated signal transduction|endomembrane system|GDP binding|TOR signaling|metal ion binding|positive regulation of NF-kappaB transcription factor activity RHEX 15.52397665 17.25425146 13.79370183 0.799437858 -0.3229422 0.834216248 1 0.692995216 0.577870969 440712 regulator of hemoglobinization and erythroid cell expansion "GO:0005128,GO:0005515,GO:0005886,GO:0016021,GO:0036018,GO:0038162,GO:0043249,GO:0045648" erythropoietin receptor binding|protein binding|plasma membrane|integral component of membrane|cellular response to erythropoietin|erythropoietin-mediated signaling pathway|erythrocyte maturation|positive regulation of erythrocyte differentiation RHNO1 1377.702513 1233.171502 1522.233524 1.23440537 0.303816243 0.364990337 1 30.51088724 39.28516386 83695 RAD9-HUS1-RAD1 interacting nuclear orphan 1 "GO:0000077,GO:0000725,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006260,GO:0007049,GO:0034644,GO:0070318,GO:0071479,GO:1901796" DNA damage checkpoint|recombinational repair|protein binding|nucleus|nucleoplasm|chromosome|DNA replication|cell cycle|cellular response to UV|positive regulation of G0 to G1 transition|cellular response to ionizing radiation|regulation of signal transduction by p53 class mediator RHOA 12131.99727 11346.19277 12917.80177 1.138514216 0.187152306 0.584823791 1 281.8266978 334.6852089 387 ras homolog family member A "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007015,GO:0007163,GO:0007179,GO:0007186,GO:0007266,GO:0008360,GO:0010812,GO:0016032,GO:0016477,GO:0016579,GO:0017022,GO:0019901,GO:0021762,GO:0030027,GO:0030036,GO:0030054,GO:0030334,GO:0030496,GO:0030667,GO:0030865,GO:0031122,GO:0031234,GO:0031410,GO:0031532,GO:0031982,GO:0032154,GO:0032467,GO:0032956,GO:0033688,GO:0034329,GO:0034446,GO:0035385,GO:0036089,GO:0038027,GO:0042995,GO:0043123,GO:0043149,GO:0043197,GO:0043231,GO:0043296,GO:0043297,GO:0043312,GO:0043542,GO:0043931,GO:0044319,GO:0045198,GO:0045666,GO:0045792,GO:0048010,GO:0048013,GO:0048015,GO:0050771,GO:0050772,GO:0050919,GO:0051056,GO:0051496,GO:0051893,GO:0060071,GO:0060193,GO:0061383,GO:0070062,GO:0071222,GO:0071345,GO:0071902,GO:0071944,GO:0090051,GO:0090307,GO:0097498,GO:0098794,GO:0098978,GO:0101003,GO:1901224,GO:1902766,GO:1903673,GO:1904996,GO:1905274,GO:1990869,GO:2000145,GO:2000406" "GTPase activity|protein binding|GTP binding|endosome|endoplasmic reticulum membrane|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|actin filament organization|establishment or maintenance of cell polarity|transforming growth factor beta receptor signaling pathway|G protein-coupled receptor signaling pathway|Rho protein signal transduction|regulation of cell shape|negative regulation of cell-substrate adhesion|viral process|cell migration|protein deubiquitination|myosin binding|protein kinase binding|substantia nigra development|lamellipodium|actin cytoskeleton organization|cell junction|regulation of cell migration|midbody|secretory granule membrane|cortical cytoskeleton organization|cytoplasmic microtubule organization|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|actin cytoskeleton reorganization|vesicle|cleavage furrow|positive regulation of cytokinesis|regulation of actin cytoskeleton organization|regulation of osteoblast proliferation|cell junction assembly|substrate adhesion-dependent cell spreading|Roundabout signaling pathway|cleavage furrow formation|apolipoprotein A-I-mediated signaling pathway|cell projection|positive regulation of I-kappaB kinase/NF-kappaB signaling|stress fiber assembly|dendritic spine|intracellular membrane-bounded organelle|apical junction complex|apical junction assembly|neutrophil degranulation|endothelial cell migration|ossification involved in bone maturation|wound healing, spreading of cells|establishment of epithelial cell apical/basal polarity|positive regulation of neuron differentiation|negative regulation of cell size|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|phosphatidylinositol-mediated signaling|negative regulation of axonogenesis|positive regulation of axonogenesis|negative chemotaxis|regulation of small GTPase mediated signal transduction|positive regulation of stress fiber assembly|regulation of focal adhesion assembly|Wnt signaling pathway, planar cell polarity pathway|positive regulation of lipase activity|trabecula morphogenesis|extracellular exosome|cellular response to lipopolysaccharide|cellular response to cytokine stimulus|positive regulation of protein serine/threonine kinase activity|cell periphery|negative regulation of cell migration involved in sprouting angiogenesis|mitotic spindle assembly|endothelial tube lumen extension|postsynapse|glutamatergic synapse|ficolin-1-rich granule membrane|positive regulation of NIK/NF-kappaB signaling|skeletal muscle satellite cell migration|mitotic cleavage furrow formation|positive regulation of leukocyte adhesion to vascular endothelial cell|regulation of modification of postsynaptic actin cytoskeleton|cellular response to chemokine|regulation of cell motility|positive regulation of T cell migration" "hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04072,hsa04144,hsa04150,hsa04270,hsa04310,hsa04350,hsa04360,hsa04510,hsa04520,hsa04530,hsa04611,hsa04621,hsa04625,hsa04660,hsa04670,hsa04722,hsa04810,hsa04921,hsa04928,hsa04972,hsa05100,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05152,hsa05163,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05418" "Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Endocytosis|mTOR signaling pathway|Vascular smooth muscle contraction|Wnt signaling pathway|TGF-beta signaling pathway|Axon guidance|Focal adhesion|Adherens junction|Tight junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Parathyroid hormone synthesis, secretion and action|Pancreatic secretion|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Tuberculosis|Human cytomegalovirus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Fluid shear stress and atherosclerosis" RHOB 627.8571546 858.6527492 397.0615599 0.462423908 -1.112712106 0.004360544 0.243721434 18.37251061 8.861856559 388 ras homolog family member B "GO:0000281,GO:0001525,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0006886,GO:0006915,GO:0007015,GO:0007155,GO:0007163,GO:0007186,GO:0007266,GO:0008333,GO:0008360,GO:0010008,GO:0010595,GO:0016477,GO:0019003,GO:0019901,GO:0030154,GO:0030334,GO:0030336,GO:0030865,GO:0031410,GO:0031902,GO:0032154,GO:0032956,GO:0042995,GO:0043065,GO:0043231,GO:0045766,GO:0045786,GO:0051056,GO:0061154,GO:0070062,GO:0070301,GO:0071479" mitotic cytokinesis|angiogenesis|GTPase activity|protein binding|GTP binding|nucleus|early endosome|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|intracellular protein transport|apoptotic process|actin filament organization|cell adhesion|establishment or maintenance of cell polarity|G protein-coupled receptor signaling pathway|Rho protein signal transduction|endosome to lysosome transport|regulation of cell shape|endosome membrane|positive regulation of endothelial cell migration|cell migration|GDP binding|protein kinase binding|cell differentiation|regulation of cell migration|negative regulation of cell migration|cortical cytoskeleton organization|cytoplasmic vesicle|late endosome membrane|cleavage furrow|regulation of actin cytoskeleton organization|cell projection|positive regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of angiogenesis|negative regulation of cell cycle|regulation of small GTPase mediated signal transduction|endothelial tube morphogenesis|extracellular exosome|cellular response to hydrogen peroxide|cellular response to ionizing radiation hsa05132 Salmonella infection RHOBTB1 18.165287 29.43372308 6.896850916 0.234317993 -2.093460354 0.077698662 1 0.141689406 0.034630515 9886 Rho related BTB domain containing 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007264,GO:0008360,GO:0019901,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0043652,GO:0051056" GTPase activity|protein binding|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|protein kinase binding|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|engulfment of apoptotic cell|regulation of small GTPase mediated signal transduction hsa04120 Ubiquitin mediated proteolysis RHOBTB2 734.0269414 673.930763 794.1231197 1.178345259 0.236762316 0.527694778 1 3.145536417 3.866190116 23221 Rho related BTB domain containing 2 "GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007264,GO:0008360,GO:0019901,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0043652,GO:0051056" GTPase activity|protein binding|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|protein kinase binding|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|engulfment of apoptotic cell|regulation of small GTPase mediated signal transduction hsa04120 Ubiquitin mediated proteolysis RHOBTB3 1968.523423 1715.275587 2221.771259 1.295285304 0.373269906 0.247440669 1 14.62502649 19.75959456 22836 Rho related BTB domain containing 3 "GO:0003924,GO:0005515,GO:0005524,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0008360,GO:0008584,GO:0016477,GO:0016887,GO:0019901,GO:0030865,GO:0031267,GO:0031410,GO:0032588,GO:0032956,GO:0042147,GO:0042995,GO:0043231,GO:0070062" "GTPase activity|protein binding|ATP binding|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|regulation of cell shape|male gonad development|cell migration|ATPase activity|protein kinase binding|cortical cytoskeleton organization|small GTPase binding|cytoplasmic vesicle|trans-Golgi network membrane|regulation of actin cytoskeleton organization|retrograde transport, endosome to Golgi|cell projection|intracellular membrane-bounded organelle|extracellular exosome" RHOC 4972.118833 4814.951114 5129.286553 1.065283205 0.091237021 0.776618218 1 199.3951658 221.5621826 389 ras homolog family member C "GO:0000281,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007186,GO:0007264,GO:0008360,GO:0016477,GO:0019901,GO:0030335,GO:0030865,GO:0031334,GO:0031410,GO:0032154,GO:0032420,GO:0032956,GO:0042995,GO:0043005,GO:0043123,GO:0043231,GO:0043297,GO:0044319,GO:0051056,GO:0051496,GO:0060193,GO:0070062,GO:1902766" "mitotic cytokinesis|GTPase activity|protein binding|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|regulation of cell shape|cell migration|protein kinase binding|positive regulation of cell migration|cortical cytoskeleton organization|positive regulation of protein-containing complex assembly|cytoplasmic vesicle|cleavage furrow|stereocilium|regulation of actin cytoskeleton organization|cell projection|neuron projection|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|apical junction assembly|wound healing, spreading of cells|regulation of small GTPase mediated signal transduction|positive regulation of stress fiber assembly|positive regulation of lipase activity|extracellular exosome|skeletal muscle satellite cell migration" RHOD 367.3724909 327.8307778 406.914204 1.241232464 0.311773335 0.484646391 1 15.03937715 19.47147746 29984 ras homolog family member D "GO:0003924,GO:0005525,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007266,GO:0008360,GO:0010008,GO:0016477,GO:0019901,GO:0030032,GO:0030335,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0045785,GO:0048041,GO:0051017,GO:0051056" GTPase activity|GTP binding|early endosome|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|Rho protein signal transduction|regulation of cell shape|endosome membrane|cell migration|protein kinase binding|lamellipodium assembly|positive regulation of cell migration|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|positive regulation of cell adhesion|focal adhesion assembly|actin filament bundle assembly|regulation of small GTPase mediated signal transduction hsa04360 Axon guidance RHOF 3110.621801 3579.7497 2641.493901 0.737899049 -0.438504638 0.168368996 1 74.45654773 57.30806916 54509 "ras homolog family member F, filopodia associated" "GO:0003924,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007264,GO:0008360,GO:0016477,GO:0019901,GO:0030667,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0043312,GO:0051056,GO:0070062" GTPase activity|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|cell migration|protein kinase binding|secretory granule membrane|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of small GTPase mediated signal transduction|extracellular exosome RHOG 1212.708579 1134.720773 1290.696386 1.137457264 0.185812342 0.587250093 1 34.16742216 40.53808529 391 ras homolog family member G "GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007015,GO:0007163,GO:0007266,GO:0008045,GO:0008284,GO:0008360,GO:0016601,GO:0019901,GO:0030031,GO:0030036,GO:0030667,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0043312,GO:0043652,GO:0045893,GO:0051056,GO:0051897,GO:0060326,GO:0070062,GO:0090630,GO:1900027,GO:1902622,GO:1903078" "GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|actin filament organization|establishment or maintenance of cell polarity|Rho protein signal transduction|motor neuron axon guidance|positive regulation of cell population proliferation|regulation of cell shape|Rac protein signal transduction|protein kinase binding|cell projection assembly|actin cytoskeleton organization|secretory granule membrane|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|neutrophil degranulation|engulfment of apoptotic cell|positive regulation of transcription, DNA-templated|regulation of small GTPase mediated signal transduction|positive regulation of protein kinase B signaling|cell chemotaxis|extracellular exosome|activation of GTPase activity|regulation of ruffle assembly|regulation of neutrophil migration|positive regulation of protein localization to plasma membrane" "hsa05100,hsa05132,hsa05135" Bacterial invasion of epithelial cells|Salmonella infection|Yersinia infection RHOJ 27.98823961 27.40381115 28.57266808 1.042653079 0.060259212 0.992718911 1 0.379832063 0.413092569 57381 ras homolog family member J "GO:0001525,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0006897,GO:0008360,GO:0010594,GO:0016477,GO:0030031,GO:0030036,GO:0032488,GO:0051056,GO:0061299,GO:0070062,GO:0090050,GO:1903670" angiogenesis|GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|endocytosis|regulation of cell shape|regulation of endothelial cell migration|cell migration|cell projection assembly|actin cytoskeleton organization|Cdc42 protein signal transduction|regulation of small GTPase mediated signal transduction|retina vasculature morphogenesis in camera-type eye|extracellular exosome|positive regulation of cell migration involved in sprouting angiogenesis|regulation of sprouting angiogenesis hsa05132 Salmonella infection RHOQ 1368.73245 1394.549501 1342.9154 0.962974351 -0.054430723 0.873094864 1 19.94606397 20.03493127 23433 ras homolog family member Q "GO:0003924,GO:0005515,GO:0005522,GO:0005525,GO:0005829,GO:0005884,GO:0005886,GO:0006897,GO:0007264,GO:0008286,GO:0008360,GO:0016477,GO:0030031,GO:0030660,GO:0030866,GO:0032427,GO:0032869,GO:0032956,GO:0045121,GO:0045944,GO:0046039,GO:0046326,GO:0051056,GO:0051491,GO:0070062,GO:1903077" GTPase activity|protein binding|profilin binding|GTP binding|cytosol|actin filament|plasma membrane|endocytosis|small GTPase mediated signal transduction|insulin receptor signaling pathway|regulation of cell shape|cell migration|cell projection assembly|Golgi-associated vesicle membrane|cortical actin cytoskeleton organization|GBD domain binding|cellular response to insulin stimulus|regulation of actin cytoskeleton organization|membrane raft|positive regulation of transcription by RNA polymerase II|GTP metabolic process|positive regulation of glucose import|regulation of small GTPase mediated signal transduction|positive regulation of filopodium assembly|extracellular exosome|negative regulation of protein localization to plasma membrane hsa04910 Insulin signaling pathway RHOT1 648.5491911 656.6765115 640.4218708 0.975247111 -0.036160275 0.929104348 1 4.630147389 4.710048922 55288 ras homolog family member T1 "GO:0003674,GO:0003924,GO:0005509,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0005829,GO:0005886,GO:0007005,GO:0010821,GO:0016020,GO:0016579,GO:0019725,GO:0031307,GO:0034640,GO:0046928,GO:0047497,GO:0051056,GO:0097345,GO:1902513" molecular_function|GTPase activity|calcium ion binding|protein binding|GTP binding|mitochondrion|mitochondrial outer membrane|cytosol|plasma membrane|mitochondrion organization|regulation of mitochondrion organization|membrane|protein deubiquitination|cellular homeostasis|integral component of mitochondrial outer membrane|establishment of mitochondrion localization by microtubule attachment|regulation of neurotransmitter secretion|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|mitochondrial outer membrane permeabilization|regulation of organelle transport along microtubule hsa04137 Mitophagy - animal RHOT2 1151.367086 1150.960068 1151.774103 1.000707266 0.001020008 1 1 21.31337006 22.24718716 89941 ras homolog family member T2 "GO:0003924,GO:0005509,GO:0005515,GO:0005525,GO:0005739,GO:0005829,GO:0005886,GO:0007005,GO:0010821,GO:0016020,GO:0019725,GO:0031307,GO:0047497,GO:0051056,GO:0097345" GTPase activity|calcium ion binding|protein binding|GTP binding|mitochondrion|cytosol|plasma membrane|mitochondrion organization|regulation of mitochondrion organization|membrane|cellular homeostasis|integral component of mitochondrial outer membrane|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|mitochondrial outer membrane permeabilization hsa04137 Mitophagy - animal RHOU 41.01936367 42.62815067 39.41057666 0.924519972 -0.113223609 0.927620738 1 0.544505788 0.525091185 58480 ras homolog family member U "GO:0000139,GO:0002102,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0005925,GO:0006897,GO:0007010,GO:0008360,GO:0016477,GO:0019221,GO:0030031,GO:0032488,GO:0042995,GO:0046872,GO:0051056,GO:1903955" Golgi membrane|podosome|GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|focal adhesion|endocytosis|cytoskeleton organization|regulation of cell shape|cell migration|cytokine-mediated signaling pathway|cell projection assembly|Cdc42 protein signal transduction|cell projection|metal ion binding|regulation of small GTPase mediated signal transduction|positive regulation of protein targeting to mitochondrion RHOV 13.52375626 15.22433953 11.823173 0.776596776 -0.364762376 0.820851526 1 0.467308539 0.378543009 171177 ras homolog family member V "GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0006897,GO:0010008,GO:0016477,GO:0030031,GO:0032488,GO:0046872,GO:0051056" GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|endocytosis|endosome membrane|cell migration|cell projection assembly|Cdc42 protein signal transduction|metal ion binding|regulation of small GTPase mediated signal transduction RHPN1 249.487657 284.1876711 214.7876428 0.755795077 -0.403932973 0.422118752 1 2.433734019 1.918638263 114822 rhophilin Rho GTPase binding protein 1 "GO:0005515,GO:0005829,GO:0007165" protein binding|cytosol|signal transduction RHPN2 362.7012686 311.5914823 413.8110549 1.328056377 0.409316391 0.359679756 1 4.507571936 6.244175595 85415 rhophilin Rho GTPase binding protein 2 "GO:0005829,GO:0007165,GO:0048471" cytosol|signal transduction|perinuclear region of cytoplasm RIBC1 20.53937339 23.34398727 17.7347595 0.759714238 -0.396471236 0.75049179 1 0.728909126 0.57761649 158787 RIB43A domain with coiled-coils 1 GO:0005515 protein binding RIBC2 131.4504059 95.40586103 167.4949508 1.755604415 0.811967803 0.190482843 1 2.556598037 4.681715783 26150 RIB43A domain with coiled-coils 2 "GO:0005515,GO:0005634" protein binding|nucleus RIC1 731.786467 689.1551025 774.4178314 1.123720667 0.168283457 0.654736512 1 3.993966672 4.681432163 57589 "RIC1 homolog, RAB6A GEF complex partner 1" "GO:0000139,GO:0003330,GO:0005085,GO:0005515,GO:0005829,GO:0006886,GO:0016020,GO:0031267,GO:0032588,GO:0032991,GO:0034066,GO:0042147,GO:0043547,GO:1903363,GO:1904888" "Golgi membrane|regulation of extracellular matrix constituent secretion|guanyl-nucleotide exchange factor activity|protein binding|cytosol|intracellular protein transport|membrane|small GTPase binding|trans-Golgi network membrane|protein-containing complex|RIC1-RGP1 guanyl-nucleotide exchange factor complex|retrograde transport, endosome to Golgi|positive regulation of GTPase activity|negative regulation of cellular protein catabolic process|cranial skeletal system development" RIC8A 3830.640764 3767.516555 3893.764974 1.033509719 0.047551955 0.882018617 1 52.7103377 56.82327927 60626 RIC8 guanine nucleotide exchange factor A "GO:0001701,GO:0001944,GO:0001965,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005886,GO:0007186,GO:0007193,GO:0008542,GO:0042074,GO:0043547,GO:0070586,GO:0071711" in utero embryonic development|vasculature development|G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|visual learning|cell migration involved in gastrulation|positive regulation of GTPase activity|cell-cell adhesion involved in gastrulation|basement membrane organization RIC8B 509.8983378 439.4759343 580.3207413 1.320483549 0.401066328 0.324372596 1 4.175967297 5.751829629 55188 RIC8 guanine nucleotide exchange factor B "GO:0001965,GO:0005085,GO:0005096,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0007186,GO:0008277,GO:0043547" G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|cytoplasm|cytosol|plasma membrane|cell cortex|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|positive regulation of GTPase activity RICTOR 1711.964725 1553.897588 1870.031863 1.203446017 0.267171428 0.413571145 1 8.113343401 10.18456306 253260 RPTOR independent companion of MTOR complex 2 "GO:0001938,GO:0005515,GO:0005829,GO:0009792,GO:0010468,GO:0016032,GO:0018105,GO:0019901,GO:0030838,GO:0031532,GO:0031932,GO:0032008,GO:0032148,GO:0032956,GO:0033135,GO:0038203,GO:0043022,GO:0043087,GO:0043539,GO:0050727,GO:0050731,GO:0051896,GO:0051897,GO:0071902,GO:2000114" positive regulation of endothelial cell proliferation|protein binding|cytosol|embryo development ending in birth or egg hatching|regulation of gene expression|viral process|peptidyl-serine phosphorylation|protein kinase binding|positive regulation of actin filament polymerization|actin cytoskeleton reorganization|TORC2 complex|positive regulation of TOR signaling|activation of protein kinase B activity|regulation of actin cytoskeleton organization|regulation of peptidyl-serine phosphorylation|TORC2 signaling|ribosome binding|regulation of GTPase activity|protein serine/threonine kinase activator activity|regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|regulation of protein kinase B signaling|positive regulation of protein kinase B signaling|positive regulation of protein serine/threonine kinase activity|regulation of establishment of cell polarity hsa04150 mTOR signaling pathway RIDA 282.2213478 332.9055576 231.5371379 0.695503973 -0.523869339 0.277640265 1 17.08256542 12.39277707 10247 reactive intermediate imine deaminase A homolog "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005829,GO:0006402,GO:0016892,GO:0017148,GO:0019239,GO:0019518,GO:0061157,GO:0070062,GO:0090502,GO:0120241,GO:1901565" "RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|peroxisome|cytosol|mRNA catabolic process|endoribonuclease activity, producing 3'-phosphomonoesters|negative regulation of translation|deaminase activity|L-threonine catabolic process to glycine|mRNA destabilization|extracellular exosome|RNA phosphodiester bond hydrolysis, endonucleolytic|2-iminobutanoate/2-iminopropanoate deaminase|organonitrogen compound catabolic process" RIF1 1613.670373 1637.123977 1590.216768 0.971347797 -0.041940141 0.900258396 1 8.320577422 8.430321849 55183 replication timing regulatory factor 1 "GO:0000122,GO:0000723,GO:0000781,GO:0000785,GO:0000793,GO:0001939,GO:0001940,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006303,GO:0006348,GO:0006974,GO:0007049,GO:0016604,GO:0019827,GO:0031965,GO:0035861,GO:0043247,GO:0045830,GO:0051233,GO:0051574,GO:1990830,GO:2000042,GO:2001034" "negative regulation of transcription by RNA polymerase II|telomere maintenance|chromosome, telomeric region|chromatin|condensed chromosome|female pronucleus|male pronucleus|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|double-strand break repair via nonhomologous end joining|chromatin silencing at telomere|cellular response to DNA damage stimulus|cell cycle|nuclear body|stem cell population maintenance|nuclear membrane|site of double-strand break|telomere maintenance in response to DNA damage|positive regulation of isotype switching|spindle midzone|positive regulation of histone H3-K9 methylation|cellular response to leukemia inhibitory factor|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining" hsa04550 Signaling pathways regulating pluripotency of stem cells RILP 148.0581242 186.7518982 109.3643502 0.585613058 -0.771980371 0.195078879 1 6.063028732 3.703533764 83547 Rab interacting lysosomal protein "GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0008333,GO:0010796,GO:0015031,GO:0019886,GO:0030670,GO:0031267,GO:0031902,GO:0032509,GO:0032991,GO:0036064,GO:0042177,GO:0045022,GO:0045732,GO:0046983,GO:0051959,GO:0060271,GO:0070676" protein binding|cytoplasm|lysosome|lysosomal membrane|late endosome|cytosol|endosome to lysosome transport|regulation of multivesicular body size|protein transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|phagocytic vesicle membrane|small GTPase binding|late endosome membrane|endosome transport via multivesicular body sorting pathway|protein-containing complex|ciliary basal body|negative regulation of protein catabolic process|early endosome to late endosome transport|positive regulation of protein catabolic process|protein dimerization activity|dynein light intermediate chain binding|cilium assembly|intralumenal vesicle formation "hsa04145,hsa05132" Phagosome|Salmonella infection RILPL1 330.3508464 322.7559979 337.9456949 1.047062478 0.06634753 0.891394883 1 3.304316289 3.608860855 353116 Rab interacting lysosomal protein like 1 "GO:0003382,GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0036064,GO:0046983,GO:0060271,GO:1901214,GO:1903445" epithelial cell morphogenesis|protein binding|nucleoplasm|cytoplasm|centrosome|centriole|cytosol|plasma membrane|cilium|ciliary basal body|protein dimerization activity|cilium assembly|regulation of neuron death|protein transport from ciliary membrane to plasma membrane RILPL2 424.9374682 491.2386887 358.6362476 0.730065151 -0.453902878 0.287407583 1 9.90426218 7.54222834 196383 Rab interacting lysosomal protein like 2 "GO:0003382,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005929,GO:0016020,GO:0036064,GO:0042802,GO:0046983,GO:0060271,GO:1903445" epithelial cell morphogenesis|protein binding|cytoplasm|centrosome|cytosol|cilium|membrane|ciliary basal body|identical protein binding|protein dimerization activity|cilium assembly|protein transport from ciliary membrane to plasma membrane RIMBP3 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.042099868 0.034102974 85376 RIMS binding protein 3 "GO:0002177,GO:0005515,GO:0005634,GO:0005737,GO:0007274,GO:0007286,GO:0009566,GO:0030156,GO:0045202" manchette|protein binding|nucleus|cytoplasm|neuromuscular synaptic transmission|spermatid development|fertilization|benzodiazepine receptor binding|synapse RIMKLA 31.33002304 53.79266632 8.867379749 0.164843655 -2.600829734 0.012227086 0.4872522 0.226242217 0.038901094 284716 ribosomal modification protein rimK like family member A "GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006464,GO:0008652,GO:0016879,GO:0046872,GO:0072590" "protein binding|ATP binding|cytoplasm|cytosol|cellular protein modification process|cellular amino acid biosynthetic process|ligase activity, forming carbon-nitrogen bonds|metal ion binding|N-acetyl-L-aspartate-L-glutamate ligase activity" hsa00250 "Alanine, aspartate and glutamate metabolism" RIMKLB 702.5430174 676.9756309 728.1104038 1.075534141 0.105053322 0.783569642 1 5.763393424 6.46574239 57494 ribosomal modification protein rimK like family member B "GO:0005524,GO:0005737,GO:0005829,GO:0006464,GO:0008652,GO:0016879,GO:0046872,GO:0072590,GO:0072591" "ATP binding|cytoplasm|cytosol|cellular protein modification process|cellular amino acid biosynthetic process|ligase activity, forming carbon-nitrogen bonds|metal ion binding|N-acetyl-L-aspartate-L-glutamate ligase activity|citrate-L-glutamate ligase activity" hsa00250 "Alanine, aspartate and glutamate metabolism" RIMS1 86.44272566 83.22638941 89.65906191 1.07729126 0.107408354 0.895728137 1 0.290999173 0.326994781 22999 regulating synaptic membrane exocytosis 1 "GO:0003723,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0007269,GO:0007601,GO:0010628,GO:0014047,GO:0016079,GO:0017156,GO:0030154,GO:0030695,GO:0031267,GO:0042391,GO:0042734,GO:0042995,GO:0044325,GO:0045055,GO:0046872,GO:0046903,GO:0046928,GO:0048167,GO:0048786,GO:0048788,GO:0048791,GO:0050790,GO:0050806,GO:0050896,GO:0060478,GO:0061025,GO:0065003,GO:0097151,GO:1903861,GO:2000300,GO:2000463" RNA binding|protein binding|cytosol|plasma membrane|intracellular protein transport|neurotransmitter secretion|visual perception|positive regulation of gene expression|glutamate secretion|synaptic vesicle exocytosis|calcium-ion regulated exocytosis|cell differentiation|GTPase regulator activity|small GTPase binding|regulation of membrane potential|presynaptic membrane|cell projection|ion channel binding|regulated exocytosis|metal ion binding|secretion|regulation of neurotransmitter secretion|regulation of synaptic plasticity|presynaptic active zone|cytoskeleton of presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|regulation of catalytic activity|positive regulation of synaptic transmission|response to stimulus|acrosomal vesicle exocytosis|membrane fusion|protein-containing complex assembly|positive regulation of inhibitory postsynaptic potential|positive regulation of dendrite extension|regulation of synaptic vesicle exocytosis|positive regulation of excitatory postsynaptic potential "hsa04721,hsa04723" Synaptic vesicle cycle|Retrograde endocannabinoid signaling RIMS2 567.1839669 550.1061349 584.261799 1.062089226 0.086904972 0.830124817 1 2.416595982 2.677201022 9699 regulating synaptic membrane exocytosis 2 "GO:0005515,GO:0006886,GO:0010628,GO:0017156,GO:0017157,GO:0019933,GO:0030073,GO:0030154,GO:0042391,GO:0042734,GO:0042995,GO:0044325,GO:0046872,GO:0048167,GO:0048786,GO:0048788,GO:0048791,GO:0050806,GO:0061669,GO:0070062,GO:0097151,GO:1903861,GO:2000300,GO:2000463" protein binding|intracellular protein transport|positive regulation of gene expression|calcium-ion regulated exocytosis|regulation of exocytosis|cAMP-mediated signaling|insulin secretion|cell differentiation|regulation of membrane potential|presynaptic membrane|cell projection|ion channel binding|metal ion binding|regulation of synaptic plasticity|presynaptic active zone|cytoskeleton of presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|positive regulation of synaptic transmission|spontaneous neurotransmitter secretion|extracellular exosome|positive regulation of inhibitory postsynaptic potential|positive regulation of dendrite extension|regulation of synaptic vesicle exocytosis|positive regulation of excitatory postsynaptic potential hsa04911 Insulin secretion RIMS3 297.768335 250.6941242 344.8425458 1.37555097 0.460009599 0.332534115 1 1.71392724 2.459149878 9783 regulating synaptic membrane exocytosis 3 "GO:0005515,GO:0017156,GO:0042391,GO:0042734,GO:0044325,GO:0048167,GO:0048786,GO:0048788,GO:0048791,GO:0050806,GO:2000300" protein binding|calcium-ion regulated exocytosis|regulation of membrane potential|presynaptic membrane|ion channel binding|regulation of synaptic plasticity|presynaptic active zone|cytoskeleton of presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|positive regulation of synaptic transmission|regulation of synaptic vesicle exocytosis RIN1 297.4456873 363.3542367 231.5371379 0.637221517 -0.650133112 0.170650922 1 4.243165841 2.820306888 9610 Ras and Rab interactor 1 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006897,GO:0007165,GO:0043547" GTPase activator activity|protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|endocytosis|signal transduction|positive regulation of GTPase activity hsa04014 Ras signaling pathway RIN2 3468.837915 4157.259646 2780.416183 0.668809846 -0.580332009 0.068693814 1 23.17307233 16.16598624 54453 Ras and Rab interactor 2 "GO:0005085,GO:0005096,GO:0005575,GO:0005829,GO:0006897,GO:0007264,GO:0010595,GO:0030695,GO:0043547,GO:1904906,GO:2001214" guanyl-nucleotide exchange factor activity|GTPase activator activity|cellular_component|cytosol|endocytosis|small GTPase mediated signal transduction|positive regulation of endothelial cell migration|GTPase regulator activity|positive regulation of GTPase activity|positive regulation of endothelial cell-matrix adhesion via fibronectin|positive regulation of vasculogenesis RIN3 445.1556777 425.2665507 465.0448046 1.093537227 0.129002334 0.763187049 1 3.998190188 4.560505155 79890 Ras and Rab interactor 3 "GO:0002091,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005769,GO:0005829,GO:0006897,GO:0007165,GO:0030139,GO:0030424,GO:0030425,GO:0031267,GO:0031410,GO:0031982,GO:0043025,GO:0043547,GO:0060755,GO:0097494" negative regulation of receptor internalization|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|early endosome|cytosol|endocytosis|signal transduction|endocytic vesicle|axon|dendrite|small GTPase binding|cytoplasmic vesicle|vesicle|neuronal cell body|positive regulation of GTPase activity|negative regulation of mast cell chemotaxis|regulation of vesicle size RING1 713.1730851 662.7662473 763.5799228 1.152110455 0.204279037 0.588605298 1 19.28016791 23.16972394 6015 ring finger protein 1 "GO:0000151,GO:0001739,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0009952,GO:0016607,GO:0031519,GO:0035102,GO:0035518,GO:0045892,GO:0046872,GO:0048593,GO:0050790,GO:0061630,GO:0070317,GO:0097027" "ubiquitin ligase complex|sex chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|anterior/posterior pattern specification|nuclear speck|PcG protein complex|PRC1 complex|histone H2A monoubiquitination|negative regulation of transcription, DNA-templated|metal ion binding|camera-type eye morphogenesis|regulation of catalytic activity|ubiquitin protein ligase activity|negative regulation of G0 to G1 transition|ubiquitin-protein transferase activator activity" other RINT1 544.2111241 528.7920595 559.6301886 1.058318064 0.081773276 0.842050723 1 9.254130044 10.21569073 60561 RAD50 interactor 1 "GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0006890,GO:0007049,GO:0015031,GO:0060628,GO:0070939,GO:1902504" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|cell cycle|protein transport|regulation of ER to Golgi vesicle-mediated transport|Dsl1/NZR complex|regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" RIOK1 214.0950885 255.768904 172.4212729 0.674129146 -0.568903093 0.281115127 1 4.743241556 3.335295184 83732 RIO kinase 1 "GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0016787,GO:0030490,GO:0030688,GO:0034708,GO:0042274,GO:0046872,GO:0106310,GO:0106311,GO:2000234" "protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|hydrolase activity|maturation of SSU-rRNA|preribosome, small subunit precursor|methyltransferase complex|ribosomal small subunit biogenesis|metal ion binding|protein serine kinase activity|protein threonine kinase activity|positive regulation of rRNA processing" hsa03008 Ribosome biogenesis in eukaryotes RIOK2 413.716291 431.3562866 396.0762955 0.918211483 -0.123101621 0.778665578 1 4.61972387 4.424606642 55781 RIO kinase 2 "GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007049,GO:0030071,GO:0030490,GO:0030688,GO:0042274,GO:0046777,GO:0046872,GO:0106310,GO:0106311,GO:2000208,GO:2000234" "protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell cycle|regulation of mitotic metaphase/anaphase transition|maturation of SSU-rRNA|preribosome, small subunit precursor|ribosomal small subunit biogenesis|protein autophosphorylation|metal ion binding|protein serine kinase activity|protein threonine kinase activity|positive regulation of ribosomal small subunit export from nucleus|positive regulation of rRNA processing" hsa03008 Ribosome biogenesis in eukaryotes RIOK3 1380.331453 1581.301399 1179.361507 0.745817026 -0.423106362 0.206936314 1 19.83341688 15.42928367 8780 RIO kinase 3 "GO:0004674,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007059,GO:0030490,GO:0030688,GO:0031333,GO:0032728,GO:0039534,GO:0043124,GO:0045087,GO:0045089,GO:0046872,GO:0051607,GO:0071359,GO:0089720,GO:0098586,GO:0106310,GO:0106311,GO:1990786" "protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|chromosome segregation|maturation of SSU-rRNA|preribosome, small subunit precursor|negative regulation of protein-containing complex assembly|positive regulation of interferon-beta production|negative regulation of MDA-5 signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of innate immune response|metal ion binding|defense response to virus|cellular response to dsRNA|caspase binding|cellular response to virus|protein serine kinase activity|protein threonine kinase activity|cellular response to dsDNA" RIOX1 324.7510212 344.0700733 305.4319691 0.887702805 -0.171851339 0.713746808 1 7.077959141 6.55377569 79697 ribosomal oxygenase 1 "GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0016706,GO:0032453,GO:0034720,GO:0045668,GO:0045892,GO:0051864,GO:0055114,GO:0070544" "iron ion binding|protein binding|nucleus|nucleoplasm|nucleolus|2-oxoglutarate-dependent dioxygenase activity|histone demethylase activity (H3-K4 specific)|histone H3-K4 demethylation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation" RIOX2 567.8762752 664.7961593 470.9563911 0.70842225 -0.49731857 0.209391093 1 5.401825799 3.991615474 84864 ribosomal oxygenase 2 "GO:0003714,GO:0005515,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0016706,GO:0032453,GO:0034720,GO:0042254,GO:0042802,GO:0045892,GO:0046872,GO:0051864,GO:0055114,GO:0070544" "transcription corepressor activity|protein binding|nucleoplasm|transcription regulator complex|nucleolus|cytosol|2-oxoglutarate-dependent dioxygenase activity|histone demethylase activity (H3-K4 specific)|histone H3-K4 demethylation|ribosome biogenesis|identical protein binding|negative regulation of transcription, DNA-templated|metal ion binding|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation" RIPK1 773.9395528 741.9328129 805.9462927 1.086279349 0.119395156 0.749205029 1 7.706373993 8.731875495 8737 receptor interacting serine/threonine kinase 1 "GO:0001934,GO:0002756,GO:0004672,GO:0004674,GO:0004706,GO:0005123,GO:0005515,GO:0005524,GO:0005739,GO:0005829,GO:0005886,GO:0006915,GO:0006919,GO:0006954,GO:0007249,GO:0007256,GO:0007257,GO:0008219,GO:0010008,GO:0010803,GO:0010940,GO:0016032,GO:0016579,GO:0031264,GO:0031625,GO:0032757,GO:0032760,GO:0032991,GO:0033209,GO:0034138,GO:0034612,GO:0035666,GO:0036289,GO:0042802,GO:0042803,GO:0043065,GO:0043066,GO:0043068,GO:0043123,GO:0043124,GO:0043235,GO:0044257,GO:0044877,GO:0045121,GO:0045651,GO:0045944,GO:0046330,GO:0046777,GO:0050729,GO:0051092,GO:0060545,GO:0060546,GO:0070105,GO:0070231,GO:0070266,GO:0070301,GO:0070513,GO:0070926,GO:0071356,GO:0071550,GO:0097190,GO:0097191,GO:0097300,GO:0097342,GO:0097343,GO:0097527,GO:0106310,GO:0106311,GO:1902041,GO:1902042,GO:1903800,GO:1905206,GO:1990000,GO:2000379,GO:2001237,GO:2001238" positive regulation of protein phosphorylation|MyD88-independent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|death receptor binding|protein binding|ATP binding|mitochondrion|cytosol|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|I-kappaB kinase/NF-kappaB signaling|activation of JNKK activity|activation of JUN kinase activity|cell death|endosome membrane|regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of necrotic cell death|viral process|protein deubiquitination|death-inducing signaling complex|ubiquitin protein ligase binding|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|protein-containing complex|tumor necrosis factor-mediated signaling pathway|toll-like receptor 3 signaling pathway|response to tumor necrosis factor|TRIF-dependent toll-like receptor signaling pathway|peptidyl-serine autophosphorylation|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of programmed cell death|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|cellular protein catabolic process|protein-containing complex binding|membrane raft|positive regulation of macrophage differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|protein autophosphorylation|positive regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|positive regulation of necroptotic process|negative regulation of necroptotic process|positive regulation of interleukin-6-mediated signaling pathway|T cell apoptotic process|necroptotic process|cellular response to hydrogen peroxide|death domain binding|regulation of ATP:ADP antiporter activity|cellular response to tumor necrosis factor|death-inducing signaling complex assembly|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|programmed necrotic cell death|ripoptosome|ripoptosome assembly|necroptotic signaling pathway|protein serine kinase activity|protein threonine kinase activity|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of hydrogen peroxide-induced cell death|amyloid fibril formation|positive regulation of reactive oxygen species metabolic process|negative regulation of extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway "hsa04064,hsa04210,hsa04217,hsa04620,hsa04621,hsa04622,hsa04623,hsa04668,hsa05130,hsa05131,hsa05132,hsa05160,hsa05163,hsa05169,hsa05170" NF-kappa B signaling pathway|Apoptosis|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|TNF signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Hepatitis C|Human cytomegalovirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection RIPK2 1296.921717 1099.197314 1494.64612 1.359761438 0.443353561 0.189954094 1 21.08729781 29.90884085 8767 receptor interacting serine/threonine kinase 2 "GO:0000187,GO:0001961,GO:0002250,GO:0002827,GO:0004672,GO:0004674,GO:0004706,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005856,GO:0006915,GO:0006954,GO:0007165,GO:0007249,GO:0007254,GO:0007256,GO:0007257,GO:0010800,GO:0010942,GO:0018108,GO:0030274,GO:0031398,GO:0031663,GO:0031982,GO:0032092,GO:0032722,GO:0032727,GO:0032728,GO:0032729,GO:0032731,GO:0032735,GO:0032743,GO:0032755,GO:0032760,GO:0032991,GO:0033091,GO:0033138,GO:0034134,GO:0034142,GO:0042098,GO:0042802,GO:0042803,GO:0043065,GO:0043066,GO:0043123,GO:0043330,GO:0045087,GO:0045627,GO:0045944,GO:0046330,GO:0046641,GO:0050700,GO:0050731,GO:0050830,GO:0050852,GO:0051092,GO:0070374,GO:0070423,GO:0070427,GO:0070431,GO:0070498,GO:0070671,GO:0070673,GO:0071223,GO:0071224,GO:0071225,GO:0089720,GO:0097202,GO:0106310,GO:0106311,GO:1904417" activation of MAPK activity|positive regulation of cytokine-mediated signaling pathway|adaptive immune response|positive regulation of T-helper 1 type immune response|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|cytoplasm|cytosol|cytoskeleton|apoptotic process|inflammatory response|signal transduction|I-kappaB kinase/NF-kappaB signaling|JNK cascade|activation of JNKK activity|activation of JUN kinase activity|positive regulation of peptidyl-threonine phosphorylation|positive regulation of cell death|peptidyl-tyrosine phosphorylation|LIM domain binding|positive regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|vesicle|positive regulation of protein binding|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-2 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|protein-containing complex|positive regulation of immature T cell proliferation|positive regulation of peptidyl-serine phosphorylation|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|T cell proliferation|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|innate immune response|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of alpha-beta T cell proliferation|CARD domain binding|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-positive bacterium|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of ERK1 and ERK2 cascade|nucleotide-binding oligomerization domain containing signaling pathway|nucleotide-binding oligomerization domain containing 1 signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-12|response to interleukin-18|cellular response to lipoteichoic acid|cellular response to peptidoglycan|cellular response to muramyl dipeptide|caspase binding|activation of cysteine-type endopeptidase activity|protein serine kinase activity|protein threonine kinase activity|positive regulation of xenophagy "hsa04621,hsa04722,hsa05131,hsa05132,hsa05152" NOD-like receptor signaling pathway|Neurotrophin signaling pathway|Shigellosis|Salmonella infection|Tuberculosis RIPK3 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.083412923 11035 receptor interacting serine/threonine kinase 3 "GO:0001914,GO:0002819,GO:0003713,GO:0004672,GO:0004674,GO:0004704,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0007165,GO:0007249,GO:0010922,GO:0032147,GO:0032649,GO:0032991,GO:0033077,GO:0038061,GO:0042802,GO:0042981,GO:0043029,GO:0044877,GO:0045893,GO:0046006,GO:0046777,GO:0048535,GO:0048536,GO:0048538,GO:0051092,GO:0051351,GO:0051353,GO:0051607,GO:0060545,GO:0070235,GO:0070266,GO:0070301,GO:0097190,GO:0097300,GO:0097527,GO:0097528,GO:0106310,GO:0106311,GO:1990000,GO:2000379,GO:2000452,GO:2001244" "regulation of T cell mediated cytotoxicity|regulation of adaptive immune response|transcription coactivator activity|protein kinase activity|protein serine/threonine kinase activity|NF-kappaB-inducing kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cellular protein modification process|signal transduction|I-kappaB kinase/NF-kappaB signaling|positive regulation of phosphatase activity|activation of protein kinase activity|regulation of interferon-gamma production|protein-containing complex|T cell differentiation in thymus|NIK/NF-kappaB signaling|identical protein binding|regulation of apoptotic process|T cell homeostasis|protein-containing complex binding|positive regulation of transcription, DNA-templated|regulation of activated T cell proliferation|protein autophosphorylation|lymph node development|spleen development|thymus development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ligase activity|positive regulation of oxidoreductase activity|defense response to virus|positive regulation of necroptotic process|regulation of activation-induced cell death of T cells|necroptotic process|cellular response to hydrogen peroxide|apoptotic signaling pathway|programmed necrotic cell death|necroptotic signaling pathway|execution phase of necroptosis|protein serine kinase activity|protein threonine kinase activity|amyloid fibril formation|positive regulation of reactive oxygen species metabolic process|regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation|positive regulation of intrinsic apoptotic signaling pathway" "hsa04217,hsa04621,hsa04623,hsa04668,hsa05132" Necroptosis|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|TNF signaling pathway|Salmonella infection RIPK4 978.1723485 1300.158595 656.1861014 0.504696968 -0.986510675 0.005609911 0.289781047 17.18831798 9.048571138 54101 receptor interacting serine/threonine kinase 4 "GO:0002009,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0016020,GO:0051092,GO:0106310,GO:0106311" morphogenesis of an epithelium|protein binding|ATP binding|cytoplasm|protein phosphorylation|membrane|positive regulation of NF-kappaB transcription factor activity|protein serine kinase activity|protein threonine kinase activity RIPOR1 1820.598911 1537.658292 2103.539529 1.368014949 0.452083995 0.16409134 1 13.73249303 19.59549145 79567 RHO family interacting cell polarization regulator 1 "GO:0005515,GO:0005737,GO:0005794,GO:0007266,GO:0009267,GO:0009611,GO:0012506,GO:0016020,GO:0030335,GO:0034067,GO:0051683,GO:0070062,GO:0071889,GO:0090316" protein binding|cytoplasm|Golgi apparatus|Rho protein signal transduction|cellular response to starvation|response to wounding|vesicle membrane|membrane|positive regulation of cell migration|protein localization to Golgi apparatus|establishment of Golgi localization|extracellular exosome|14-3-3 protein binding|positive regulation of intracellular protein transport RIPOR2 29.36221581 20.29911937 38.42531225 1.892954642 0.920639843 0.359730447 1 0.11648298 0.229995115 9750 RHO family interacting cell polarization regulator 2 "GO:0005515,GO:0005737,GO:0005856,GO:0006935,GO:0007155,GO:0007162,GO:0007605,GO:0016324,GO:0030175,GO:0032420,GO:0035024,GO:0042802,GO:0045184,GO:0045663,GO:0048741,GO:0051260,GO:0051491,GO:0060088,GO:0060171,GO:0071260,GO:0071889,GO:0090023,GO:1901741,GO:1903904,GO:1905872,GO:1990869,GO:2000114,GO:2000391,GO:2000405,GO:2001107" protein binding|cytoplasm|cytoskeleton|chemotaxis|cell adhesion|negative regulation of cell adhesion|sensory perception of sound|apical plasma membrane|filopodium|stereocilium|negative regulation of Rho protein signal transduction|identical protein binding|establishment of protein localization|positive regulation of myoblast differentiation|skeletal muscle fiber development|protein homooligomerization|positive regulation of filopodium assembly|auditory receptor cell stereocilium organization|stereocilium membrane|cellular response to mechanical stimulus|14-3-3 protein binding|positive regulation of neutrophil chemotaxis|positive regulation of myoblast fusion|negative regulation of establishment of T cell polarity|negative regulation of protein localization to cell leading edge|cellular response to chemokine|regulation of establishment of cell polarity|positive regulation of neutrophil extravasation|negative regulation of T cell migration|negative regulation of Rho guanyl-nucleotide exchange factor activity RIPOR3 14.98680711 14.20938356 15.76423066 1.109423966 0.149810797 0.961565511 1 0.113797462 0.131687954 140876 RIPOR family member 3 GO:0005515 protein binding RIPPLY2 7.000771347 7.104691779 6.896850916 0.970745971 -0.042834281 1 1 0.541908998 0.548716334 134701 ripply transcriptional repressor 2 "GO:0000122,GO:0001503,GO:0001756,GO:0005515,GO:0005634,GO:0007219,GO:0007368,GO:0009880,GO:0032525,GO:0036342,GO:0060349" negative regulation of transcription by RNA polymerase II|ossification|somitogenesis|protein binding|nucleus|Notch signaling pathway|determination of left/right symmetry|embryonic pattern specification|somite rostral/caudal axis specification|post-anal tail morphogenesis|bone morphogenesis RIPPLY3 24.42104795 19.2841634 29.5579325 1.532756796 0.616128801 0.573062254 1 0.447400296 0.715295424 53820 ripply transcriptional repressor 3 "GO:0000122,GO:0005515,GO:0005634,GO:0007507,GO:0008150,GO:0008285,GO:0009880,GO:0060037" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|heart development|biological_process|negative regulation of cell population proliferation|embryonic pattern specification|pharyngeal system development RIT1 563.3347055 522.7023237 603.9670873 1.155470446 0.20848036 0.601241968 1 7.715834658 9.299459007 6016 Ras like without CAAX 1 "GO:0003924,GO:0005515,GO:0005516,GO:0005525,GO:0005886,GO:0007165,GO:0007265,GO:0019003" GTPase activity|protein binding|calmodulin binding|GTP binding|plasma membrane|signal transduction|Ras protein signal transduction|GDP binding RITA1 837.146171 920.5650633 753.7272787 0.818765896 -0.288477084 0.428688684 1 23.09230951 19.72164078 84934 RBPJ interacting and tubulin associated 1 "GO:0000122,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0007219,GO:0015631,GO:0022008,GO:0045746,GO:0051168" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|Notch signaling pathway|tubulin binding|neurogenesis|negative regulation of Notch signaling pathway|nuclear export RLF 1128.016171 1373.235425 882.7969172 0.64285912 -0.637425483 0.0654248 1 10.93374152 7.33163004 6018 RLF zinc finger "GO:0000981,GO:0001228,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0044030,GO:0045893,GO:0045944,GO:0046872,GO:0097692" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of DNA methylation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|histone H3-K4 monomethylation" RLIM 2173.714513 2237.97791 2109.451116 0.942570124 -0.085328141 0.79115318 1 10.66582159 10.48633951 51132 "ring finger protein, LIM domain interacting" "GO:0000122,GO:0000209,GO:0003714,GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0016567,GO:0017053,GO:0043433,GO:0045892,GO:0046872,GO:0060816,GO:0061630,GO:1900095" "negative regulation of transcription by RNA polymerase II|protein polyubiquitination|transcription corepressor activity|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|transcription repressor complex|negative regulation of DNA-binding transcription factor activity|negative regulation of transcription, DNA-templated|metal ion binding|random inactivation of X chromosome|ubiquitin protein ligase activity|regulation of dosage compensation by inactivation of X chromosome" RLN1 3.47811701 2.029911937 4.926322083 2.426864926 1.279093814 0.644064692 1 0.101890861 0.257926976 6013 relaxin 1 "GO:0005179,GO:0005515,GO:0005576,GO:0007165,GO:0007565" hormone activity|protein binding|extracellular region|signal transduction|female pregnancy "hsa04080,hsa04926" Neuroactive ligand-receptor interaction|Relaxin signaling pathway RLN2 14.0609258 18.26920743 9.852644165 0.539303317 -0.890831188 0.491533239 1 0.379364865 0.213405755 6019 relaxin 2 "GO:0005179,GO:0005576,GO:0007186,GO:0007565,GO:0010628,GO:0045766,GO:0050790" hormone activity|extracellular region|G protein-coupled receptor signaling pathway|female pregnancy|positive regulation of gene expression|positive regulation of angiogenesis|regulation of catalytic activity "hsa04080,hsa04926" Neuroactive ligand-receptor interaction|Relaxin signaling pathway RMC1 738.9923576 743.9627248 734.0219903 0.986638128 -0.019407054 0.962476275 1 17.11907654 17.61790071 29919 regulator of MON1-CCZ1 "GO:0005515,GO:0005765,GO:0006914,GO:0010506,GO:0031902,GO:0035658" protein binding|lysosomal membrane|autophagy|regulation of autophagy|late endosome membrane|Mon1-Ccz1 complex RMDN1 978.4789126 1018.000836 938.956989 0.922353848 -0.116607768 0.743559237 1 7.401399809 7.120776559 51115 regulator of microtubule dynamics 1 "GO:0005737,GO:0005876,GO:0007052,GO:0008017,GO:0051315,GO:0097431" cytoplasm|spindle microtubule|mitotic spindle organization|microtubule binding|attachment of mitotic spindle microtubules to kinetochore|mitotic spindle pole RMDN2 24.53981416 27.40381115 21.67581716 0.790978198 -0.338290165 0.775651895 1 0.295739689 0.244000128 151393 regulator of microtubule dynamics 2 "GO:0005515,GO:0005794,GO:0005829,GO:0005876,GO:0008017,GO:0016021,GO:0072686,GO:0097431" protein binding|Golgi apparatus|cytosol|spindle microtubule|microtubule binding|integral component of membrane|mitotic spindle|mitotic spindle pole RMDN3 707.872897 670.8858951 744.8598989 1.110263167 0.150901681 0.690962303 1 10.0586157 11.64877021 55177 regulator of microtubule dynamics 3 "GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005876,GO:0006874,GO:0006915,GO:0008017,GO:0016021,GO:0030154,GO:0044232,GO:0045171,GO:0097431" protein binding|nucleus|mitochondrion|mitochondrial outer membrane|spindle microtubule|cellular calcium ion homeostasis|apoptotic process|microtubule binding|integral component of membrane|cell differentiation|organelle membrane contact site|intercellular bridge|mitotic spindle pole RMI1 324.8158475 281.1428032 368.4888918 1.310682285 0.390318013 0.398572952 1 3.896795614 5.327469684 80010 RecQ mediated genome instability 1 "GO:0000166,GO:0000712,GO:0000724,GO:0002023,GO:0005515,GO:0005654,GO:0006260,GO:0009749,GO:0016604,GO:0031422,GO:0035264,GO:0042593,GO:1901796" nucleotide binding|resolution of meiotic recombination intermediates|double-strand break repair via homologous recombination|reduction of food intake in response to dietary excess|protein binding|nucleoplasm|DNA replication|response to glucose|nuclear body|RecQ family helicase-topoisomerase III complex|multicellular organism growth|glucose homeostasis|regulation of signal transduction by p53 class mediator hsa03460 Fanconi anemia pathway RMI2 324.8158475 281.1428032 368.4888918 1.310682285 0.390318013 0.398572952 1 9.97819984 13.64160773 116028 RecQ mediated genome instability 2 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0006260,GO:0006281,GO:0016607,GO:0033045,GO:0043007,GO:1901796,GO:2000042" DNA binding|protein binding|nucleoplasm|cytosol|DNA replication|DNA repair|nuclear speck|regulation of sister chromatid segregation|maintenance of rDNA|regulation of signal transduction by p53 class mediator|negative regulation of double-strand break repair via homologous recombination hsa03460 Fanconi anemia pathway RMND1 235.2337361 252.7240361 217.7434361 0.861585781 -0.214933654 0.678983858 1 6.480800442 5.824291483 55005 required for meiotic nuclear division 1 homolog "GO:0005515,GO:0005739,GO:0006412,GO:0070131" protein binding|mitochondrion|translation|positive regulation of mitochondrial translation RMND5A 503.2511435 490.2237327 516.2785543 1.053148838 0.074709341 0.859074847 1 4.015543047 4.411131131 64795 required for meiotic nuclear division 5 homolog A "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0034657,GO:0043161,GO:0046872" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|GID complex|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding RMND5B 555.420177 554.1659587 556.6743953 1.004526508 0.006515635 0.992090985 1 6.191606183 6.487549083 64777 required for meiotic nuclear division 5 homolog B "GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016567,GO:0034657,GO:0043161,GO:0046872" ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|protein ubiquitination|GID complex|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding RNASE4 190.6350566 167.4677348 213.8023784 1.276678034 0.352394737 0.522918619 1 3.830916882 5.101525305 6038 ribonuclease A family member 4 "GO:0003676,GO:0004522,GO:0004540,GO:0005576,GO:0005615,GO:0006379,GO:0090501,GO:0090502" "nucleic acid binding|ribonuclease A activity|ribonuclease activity|extracellular region|extracellular space|mRNA cleavage|RNA phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic" RNASEH1 847.2769255 804.8600829 889.6937681 1.10540178 0.144570841 0.692493985 1 7.375307368 8.503862191 246243 ribonuclease H1 "GO:0000287,GO:0003676,GO:0003723,GO:0004523,GO:0004540,GO:0005515,GO:0005737,GO:0006401,GO:0043137,GO:0090502" "magnesium ion binding|nucleic acid binding|RNA binding|RNA-DNA hybrid ribonuclease activity|ribonuclease activity|protein binding|cytoplasm|RNA catabolic process|DNA replication, removal of RNA primer|RNA phosphodiester bond hydrolysis, endonucleolytic" hsa03030 DNA replication RNASEH2A 1042.938265 844.4433657 1241.433165 1.4701201 0.555934019 0.112421344 1 36.74233458 56.34241948 10535 ribonuclease H2 subunit A "GO:0003723,GO:0004523,GO:0004540,GO:0005654,GO:0005829,GO:0006260,GO:0006298,GO:0006401,GO:0032299,GO:0043137,GO:0046872,GO:0090502" "RNA binding|RNA-DNA hybrid ribonuclease activity|ribonuclease activity|nucleoplasm|cytosol|DNA replication|mismatch repair|RNA catabolic process|ribonuclease H2 complex|DNA replication, removal of RNA primer|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" hsa03030 DNA replication RNASEH2B 381.1607495 394.8178717 367.5036274 0.930818116 -0.103428806 0.81896831 1 4.433732232 4.30477263 79621 ribonuclease H2 subunit B "GO:0005654,GO:0006401,GO:0009259,GO:0032299" nucleoplasm|RNA catabolic process|ribonucleotide metabolic process|ribonuclease H2 complex hsa03030 DNA replication RNASEH2C 918.0835893 964.20817 871.9590086 0.904326509 -0.145084339 0.686799107 1 18.46266249 17.41548294 84153 ribonuclease H2 subunit C "GO:0005515,GO:0005634,GO:0006401,GO:0032299" protein binding|nucleus|RNA catabolic process|ribonuclease H2 complex hsa03030 DNA replication RNASEK 3111.406397 2926.118057 3296.694738 1.126644474 0.172032327 0.588911346 1 245.7670926 288.819527 440400 ribonuclease K "GO:0004521,GO:0005515,GO:0005575,GO:0016021,GO:0090502" "endoribonuclease activity|protein binding|cellular_component|integral component of membrane|RNA phosphodiester bond hydrolysis, endonucleolytic" RNASEL 28.03277694 30.44867905 25.61687483 0.841313174 -0.249285159 0.834663052 1 0.363878758 0.31932309 6041 ribonuclease L "GO:0003723,GO:0004521,GO:0004540,GO:0004672,GO:0005515,GO:0005524,GO:0005575,GO:0005759,GO:0005829,GO:0006364,GO:0006396,GO:0006397,GO:0006468,GO:0016363,GO:0019843,GO:0043021,GO:0043488,GO:0045071,GO:0045444,GO:0045944,GO:0046326,GO:0046872,GO:0051607,GO:0060337,GO:0060338,GO:0090502" "RNA binding|endoribonuclease activity|ribonuclease activity|protein kinase activity|protein binding|ATP binding|cellular_component|mitochondrial matrix|cytosol|rRNA processing|RNA processing|mRNA processing|protein phosphorylation|nuclear matrix|rRNA binding|ribonucleoprotein complex binding|regulation of mRNA stability|negative regulation of viral genome replication|fat cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|metal ion binding|defense response to virus|type I interferon signaling pathway|regulation of type I interferon-mediated signaling pathway|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa04621,hsa05160,hsa05164,hsa05168" NOD-like receptor signaling pathway|Hepatitis C|Influenza A|Herpes simplex virus 1 infection RNASET2 159.5992275 167.4677348 151.7307201 0.906029572 -0.142369955 0.815082743 1 1.008879502 0.953449294 8635 ribonuclease T2 "GO:0003723,GO:0004521,GO:0004540,GO:0005576,GO:0005615,GO:0005758,GO:0005764,GO:0005788,GO:0006401,GO:0016829,GO:0033897,GO:0035578,GO:0043202,GO:0043312,GO:0045087,GO:0070062,GO:0090502" "RNA binding|endoribonuclease activity|ribonuclease activity|extracellular region|extracellular space|mitochondrial intermembrane space|lysosome|endoplasmic reticulum lumen|RNA catabolic process|lyase activity|ribonuclease T2 activity|azurophil granule lumen|lysosomal lumen|neutrophil degranulation|innate immune response|extracellular exosome|RNA phosphodiester bond hydrolysis, endonucleolytic" RND1 13.49406471 13.19442759 13.79370183 1.045418737 0.064080923 1 1 0.404265705 0.440831998 27289 Rho family GTPase 1 "GO:0003924,GO:0005102,GO:0005515,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005938,GO:0007015,GO:0007162,GO:0007163,GO:0007264,GO:0008360,GO:0015629,GO:0016322,GO:0016477,GO:0019901,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231" GTPase activity|signaling receptor binding|protein binding|GTP binding|cytosol|cytoskeleton|plasma membrane|adherens junction|cell cortex|actin filament organization|negative regulation of cell adhesion|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|actin cytoskeleton|neuron remodeling|cell migration|protein kinase binding|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle hsa04360 Axon guidance RND2 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.054137903 0.054817971 8153 Rho family GTPase 2 "GO:0002080,GO:0003924,GO:0005515,GO:0005525,GO:0005769,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007165,GO:0007264,GO:0008360,GO:0016477,GO:0019901,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0047485,GO:0048672" acrosomal membrane|GTPase activity|protein binding|GTP binding|early endosome|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|signal transduction|small GTPase mediated signal transduction|regulation of cell shape|cell migration|protein kinase binding|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|protein N-terminus binding|positive regulation of collateral sprouting RND3 876.6282549 959.1333901 794.1231197 0.827958997 -0.272368772 0.450988776 1 18.08515361 15.61877474 390 Rho family GTPase 3 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007015,GO:0007155,GO:0007163,GO:0007264,GO:0008360,GO:0016477,GO:0019901,GO:0030036,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231" Golgi membrane|GTPase activity|protein binding|GTP binding|cytoskeleton|plasma membrane|focal adhesion|cell cortex|actin filament organization|cell adhesion|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|cell migration|protein kinase binding|actin cytoskeleton organization|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle RNF10 3300.212702 3002.239754 3598.185649 1.198500434 0.261230432 0.411578581 1 37.80528401 47.26140524 9921 ring finger protein 10 "GO:0000976,GO:0005515,GO:0005634,GO:0005737,GO:0010626,GO:0031643,GO:0045893,GO:0045944,GO:0046872,GO:0051865,GO:0061630" "transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|cytoplasm|negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity" RNF103 379.7922165 334.9354696 424.6489635 1.267853071 0.342387564 0.437869948 1 3.328748028 4.402159548 7844 ring finger protein 103 "GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0007417,GO:0016021,GO:0016567,GO:0030433,GO:0044322,GO:0046872,GO:0061630,GO:1904380" ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|central nervous system development|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|endoplasmic reticulum quality control compartment|metal ion binding|ubiquitin protein ligase activity|endoplasmic reticulum mannose trimming RNF11 1499.621438 1417.893488 1581.349389 1.115280804 0.157406995 0.635824689 1 23.36086634 27.17622324 26994 ring finger protein 11 "GO:0000151,GO:0003677,GO:0005515,GO:0005634,GO:0005769,GO:0006511,GO:0008270,GO:0051865,GO:0055037,GO:0061630,GO:0070062" ubiquitin ligase complex|DNA binding|protein binding|nucleus|early endosome|ubiquitin-dependent protein catabolic process|zinc ion binding|protein autoubiquitination|recycling endosome|ubiquitin protein ligase activity|extracellular exosome RNF111 749.8693603 813.9946866 685.7440339 0.842442887 -0.247349212 0.507322925 1 7.011217564 6.160980602 54778 ring finger protein 111 "GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0007389,GO:0016567,GO:0016605,GO:0030511,GO:0030579,GO:0031398,GO:0032184,GO:0032991,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0061630,GO:0070911" "protein polyubiquitination|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|pattern specification process|protein ubiquitination|PML body|positive regulation of transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process|positive regulation of protein ubiquitination|SUMO polymer binding|protein-containing complex|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|ubiquitin protein ligase activity|global genome nucleotide-excision repair" RNF113A 336.5120895 373.5037964 299.5203826 0.801920584 -0.318468724 0.48693644 1 15.02513872 12.56798869 7737 ring finger protein 113A "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005684,GO:0006281,GO:0016567,GO:0016607,GO:0018276,GO:0034247,GO:0046872,GO:0061630,GO:0070100,GO:0071005" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|U2-type spliceosomal complex|DNA repair|protein ubiquitination|nuclear speck|isopeptide cross-linking via N6-glycyl-L-lysine|snoRNA splicing|metal ion binding|ubiquitin protein ligase activity|negative regulation of chemokine-mediated signaling pathway|U2-type precatalytic spliceosome" RNF114 1803.206842 1729.48497 1876.928714 1.085252978 0.118031381 0.717433896 1 35.79579586 40.52088654 55905 ring finger protein 114 "GO:0000209,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006511,GO:0007275,GO:0007283,GO:0030154,GO:0046872,GO:0061630" protein polyubiquitination|protein binding|nucleus|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|multicellular organism development|spermatogenesis|cell differentiation|metal ion binding|ubiquitin protein ligase activity RNF115 902.1911899 888.0864723 916.2959074 1.031764289 0.045113418 0.902986236 1 4.914066081 5.288559734 27246 ring finger protein 115 "GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0042059,GO:0043162,GO:0046872,GO:0051865,GO:0061630,GO:0070534,GO:0070936" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|negative regulation of epidermal growth factor receptor signaling pathway|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination RNF121 639.6993788 624.1979205 655.200837 1.049668407 0.069933649 0.859599432 1 10.80800774 11.83351329 55298 ring finger protein 121 "GO:0000139,GO:0005789,GO:0016021,GO:0016567,GO:0030433,GO:0030968,GO:0046872,GO:0061630" Golgi membrane|endoplasmic reticulum membrane|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|metal ion binding|ubiquitin protein ligase activity RNF122 109.5909962 150.2134833 68.96850916 0.459136608 -1.12300463 0.089246532 1 3.461229758 1.657632602 79845 ring finger protein 122 "GO:0005515,GO:0005737,GO:0005783,GO:0005794,GO:0010917,GO:0012505,GO:0016021,GO:0043065,GO:0043161,GO:0046872,GO:0051865,GO:0061630" protein binding|cytoplasm|endoplasmic reticulum|Golgi apparatus|negative regulation of mitochondrial membrane potential|endomembrane system|integral component of membrane|positive regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity RNF123 965.5423064 941.8791387 989.2054742 1.050246718 0.070728278 0.844388681 1 10.92098343 11.96379633 63891 ring finger protein 123 "GO:0004842,GO:0005737,GO:0005829,GO:0016567,GO:0016579,GO:0031965,GO:0046872,GO:0051603" ubiquitin-protein transferase activity|cytoplasm|cytosol|protein ubiquitination|protein deubiquitination|nuclear membrane|metal ion binding|proteolysis involved in cellular protein catabolic process RNF125 142.8200408 165.4378228 120.2022588 0.726570604 -0.460825098 0.446558161 1 1.298240176 0.9838951 54941 ring finger protein 125 "GO:0000139,GO:0000209,GO:0002039,GO:0002250,GO:0005515,GO:0006511,GO:0008270,GO:0031624,GO:0032480,GO:0034098,GO:0039536,GO:0043231,GO:0061630,GO:1990830" Golgi membrane|protein polyubiquitination|p53 binding|adaptive immune response|protein binding|ubiquitin-dependent protein catabolic process|zinc ion binding|ubiquitin conjugating enzyme binding|negative regulation of type I interferon production|VCP-NPL4-UFD1 AAA ATPase complex|negative regulation of RIG-I signaling pathway|intracellular membrane-bounded organelle|ubiquitin protein ligase activity|cellular response to leukemia inhibitory factor hsa04622 RIG-I-like receptor signaling pathway RNF126 703.1489726 752.0823726 654.2155726 0.869872233 -0.201124582 0.595547569 1 23.35396627 21.19005316 55658 ring finger protein 126 "GO:0005154,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0006513,GO:0042059,GO:0042127,GO:0042147,GO:0043161,GO:0043162,GO:0046872,GO:0061630,GO:0070534,GO:0070936,GO:0071629" "epidermal growth factor receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein monoubiquitination|negative regulation of epidermal growth factor receptor signaling pathway|regulation of cell population proliferation|retrograde transport, endosome to Golgi|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|metal ion binding|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|cytoplasm protein quality control by the ubiquitin-proteasome system" RNF13 586.6611254 601.8688892 571.4533616 0.949464862 -0.074813486 0.852863542 1 8.081266165 8.003394738 11342 ring finger protein 13 "GO:0000139,GO:0004842,GO:0005515,GO:0005637,GO:0005654,GO:0005765,GO:0005783,GO:0005789,GO:0005829,GO:0006511,GO:0008432,GO:0016021,GO:0031902,GO:0043231,GO:0046872,GO:0051865,GO:0061630,GO:0070304" Golgi membrane|ubiquitin-protein transferase activity|protein binding|nuclear inner membrane|nucleoplasm|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|ubiquitin-dependent protein catabolic process|JUN kinase binding|integral component of membrane|late endosome membrane|intracellular membrane-bounded organelle|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of stress-activated protein kinase signaling cascade RNF130 1074.727024 1131.675905 1017.778142 0.899354787 -0.153037737 0.661551825 1 4.218399372 3.957260809 55819 ring finger protein 130 "GO:0004842,GO:0005737,GO:0006511,GO:0006915,GO:0012501,GO:0016021,GO:0016567,GO:0046872,GO:0061630" ubiquitin-protein transferase activity|cytoplasm|ubiquitin-dependent protein catabolic process|apoptotic process|programmed cell death|integral component of membrane|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity RNF135 478.5871199 521.6873677 435.4868721 0.83476599 -0.260556271 0.529882249 1 8.465756095 7.37133975 84282 ring finger protein 135 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0010494,GO:0010994,GO:0016567,GO:0032480,GO:0032728,GO:0039529,GO:0039552,GO:0042802,GO:0043021,GO:0045087,GO:0045088,GO:0046872,GO:0051260,GO:0061630,GO:0070534,GO:0140374,GO:1990904" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|cytoplasmic stress granule|free ubiquitin chain polymerization|protein ubiquitination|negative regulation of type I interferon production|positive regulation of interferon-beta production|RIG-I signaling pathway|RIG-I binding|identical protein binding|ribonucleoprotein complex binding|innate immune response|regulation of innate immune response|metal ion binding|protein homooligomerization|ubiquitin protein ligase activity|protein K63-linked ubiquitination|antiviral innate immune response|ribonucleoprotein complex RNF138 618.127482 631.3026123 604.9523518 0.958260492 -0.061510206 0.878004808 1 8.933570889 8.929447755 51444 ring finger protein 138 "GO:0000724,GO:0003697,GO:0005515,GO:0005634,GO:0010792,GO:0016055,GO:0016567,GO:0019901,GO:0035861,GO:0046872,GO:0061630,GO:1990830" double-strand break repair via homologous recombination|single-stranded DNA binding|protein binding|nucleus|DNA double-strand break processing involved in repair via single-strand annealing|Wnt signaling pathway|protein ubiquitination|protein kinase binding|site of double-strand break|metal ion binding|ubiquitin protein ligase activity|cellular response to leukemia inhibitory factor RNF139 1286.448026 1393.534545 1179.361507 0.846309488 -0.240742754 0.477400185 1 22.06239718 19.47591355 11236 ring finger protein 139 "GO:0002020,GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0008270,GO:0008285,GO:0012505,GO:0016021,GO:0016567,GO:0017148,GO:0018215,GO:0019787,GO:0031648,GO:0036503,GO:0036513,GO:0038023,GO:0044322,GO:0060628,GO:0061630,GO:0070613,GO:1904380,GO:2000060" protease binding|ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|negative regulation of cell population proliferation|endomembrane system|integral component of membrane|protein ubiquitination|negative regulation of translation|protein phosphopantetheinylation|ubiquitin-like protein transferase activity|protein destabilization|ERAD pathway|Derlin-1 retrotranslocation complex|signaling receptor activity|endoplasmic reticulum quality control compartment|regulation of ER to Golgi vesicle-mediated transport|ubiquitin protein ligase activity|regulation of protein processing|endoplasmic reticulum mannose trimming|positive regulation of ubiquitin-dependent protein catabolic process RNF14 1213.750505 1172.274143 1255.226867 1.070762222 0.098638145 0.774389847 1 15.08806857 16.85165732 9604 ring finger protein 14 "GO:0000151,GO:0000209,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006511,GO:0007165,GO:0016567,GO:0018215,GO:0019787,GO:0030521,GO:0031624,GO:0032436,GO:0045893,GO:0046872,GO:0050681,GO:0060765,GO:0061630" "ubiquitin ligase complex|protein polyubiquitination|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|ubiquitin-dependent protein catabolic process|signal transduction|protein ubiquitination|protein phosphopantetheinylation|ubiquitin-like protein transferase activity|androgen receptor signaling pathway|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|metal ion binding|androgen receptor binding|regulation of androgen receptor signaling pathway|ubiquitin protein ligase activity" RNF141 506.8007678 530.8219715 482.7795641 0.909494313 -0.136863478 0.740076785 1 6.639728384 6.29892201 50862 ring finger protein 141 "GO:0004842,GO:0005515,GO:0006355,GO:0016020,GO:0046872,GO:0051865" "ubiquitin-protein transferase activity|protein binding|regulation of transcription, DNA-templated|membrane|metal ion binding|protein autoubiquitination" RNF144A 11.38992389 4.059823873 18.72002391 4.61104336 2.205093232 0.115801201 1 0.009073552 0.043640775 9781 ring finger protein 144A "GO:0000151,GO:0000209,GO:0005515,GO:0005737,GO:0005794,GO:0005886,GO:0006511,GO:0010008,GO:0016021,GO:0016567,GO:0030659,GO:0031624,GO:0032436,GO:0043231,GO:0046872,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|protein binding|cytoplasm|Golgi apparatus|plasma membrane|ubiquitin-dependent protein catabolic process|endosome membrane|integral component of membrane|protein ubiquitination|cytoplasmic vesicle membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|metal ion binding|ubiquitin protein ligase activity RNF144B 34.27097051 52.77771036 15.76423066 0.298691068 -1.743273999 0.071616643 1 0.528993636 0.164811918 255488 ring finger protein 144B "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006511,GO:0006915,GO:0016021,GO:0031624,GO:0031966,GO:0032436,GO:0043066,GO:0046872,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|integral component of membrane|ubiquitin conjugating enzyme binding|mitochondrial membrane|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of apoptotic process|metal ion binding|ubiquitin protein ligase activity RNF145 3754.784069 4946.89539 2562.672747 0.518036576 -0.948874133 0.003097443 0.190915322 52.23994994 28.2279348 153830 ring finger protein 145 "GO:0005783,GO:0005789,GO:0008270,GO:0012505,GO:0016021,GO:0016567,GO:0061630" endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|endomembrane system|integral component of membrane|protein ubiquitination|ubiquitin protein ligase activity RNF146 543.1422282 455.7152298 630.5692266 1.383691361 0.468522179 0.242097885 1 2.641378888 3.812289399 81847 ring finger protein 146 "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006511,GO:0008270,GO:0016055,GO:0051865,GO:0061630,GO:0070936,GO:0072572,GO:0090263" ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|zinc ion binding|Wnt signaling pathway|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination|poly-ADP-D-ribose binding|positive regulation of canonical Wnt signaling pathway RNF149 671.4302378 705.394398 637.4660775 0.903701644 -0.146081547 0.703856078 1 3.925042604 3.699860736 284996 ring finger protein 149 "GO:0005737,GO:0006511,GO:0016020,GO:0016021,GO:0016567,GO:0031647,GO:0035690,GO:0043409,GO:0046872,GO:0061630" cytoplasm|ubiquitin-dependent protein catabolic process|membrane|integral component of membrane|protein ubiquitination|regulation of protein stability|cellular response to drug|negative regulation of MAPK cascade|metal ion binding|ubiquitin protein ligase activity RNF150 239.7686248 293.3222749 186.2149747 0.634847711 -0.65551754 0.197405129 1 1.397003803 0.925088061 57484 ring finger protein 150 "GO:0005737,GO:0006511,GO:0016021,GO:0016567,GO:0046872,GO:0061630" cytoplasm|ubiquitin-dependent protein catabolic process|integral component of membrane|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity RNF152 115.2353588 131.9442759 98.52644165 0.74672767 -0.421345905 0.518844061 1 0.703792744 0.548179713 220441 ring finger protein 152 "GO:0004842,GO:0005515,GO:0005764,GO:0005765,GO:0006915,GO:0010508,GO:0016567,GO:0031267,GO:0031301,GO:0034198,GO:0046872,GO:0061630,GO:0070534,GO:0070936,GO:1904262" ubiquitin-protein transferase activity|protein binding|lysosome|lysosomal membrane|apoptotic process|positive regulation of autophagy|protein ubiquitination|small GTPase binding|integral component of organelle membrane|cellular response to amino acid starvation|metal ion binding|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|negative regulation of TORC1 signaling hsa04150 mTOR signaling pathway RNF157 112.3889292 72.06187375 152.7159846 2.119234161 1.083543005 0.098235258 1 0.413467734 0.913979594 114804 ring finger protein 157 "GO:0005634,GO:0005737,GO:0005769,GO:0005886,GO:0008333,GO:0016567,GO:0043066,GO:0043951,GO:0044297,GO:0045744,GO:0046872,GO:0051865,GO:0061630,GO:1903861" nucleus|cytoplasm|early endosome|plasma membrane|endosome to lysosome transport|protein ubiquitination|negative regulation of apoptotic process|negative regulation of cAMP-mediated signaling|cell body|negative regulation of G protein-coupled receptor signaling pathway|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of dendrite extension RNF165 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.014376043 0 494470 ring finger protein 165 "GO:0000209,GO:0005515,GO:0005634,GO:0008045,GO:0008270,GO:0010259,GO:0030163,GO:0030513,GO:0032991,GO:0035136,GO:0060384,GO:0061061,GO:0061630" protein polyubiquitination|protein binding|nucleus|motor neuron axon guidance|zinc ion binding|multicellular organism aging|protein catabolic process|positive regulation of BMP signaling pathway|protein-containing complex|forelimb morphogenesis|innervation|muscle structure development|ubiquitin protein ligase activity RNF166 346.9640079 347.1149412 346.8130746 0.999130356 -0.001255177 1 1 5.446142262 5.67579976 115992 ring finger protein 166 "GO:0000209,GO:0005515,GO:0005737,GO:0006511,GO:0006914,GO:0045087,GO:0046872,GO:0061630" protein polyubiquitination|protein binding|cytoplasm|ubiquitin-dependent protein catabolic process|autophagy|innate immune response|metal ion binding|ubiquitin protein ligase activity RNF167 2552.262406 2454.163532 2650.361281 1.079944856 0.110957647 0.728587362 1 53.4831003 60.24681384 26001 ring finger protein 167 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0006511,GO:0008270,GO:0012505,GO:0016021,GO:0045786,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|ubiquitin-dependent protein catabolic process|zinc ion binding|endomembrane system|integral component of membrane|negative regulation of cell cycle|ubiquitin protein ligase activity RNF168 855.8567923 852.5630134 859.1505712 1.007726769 0.011104526 0.979156744 1 8.07542715 8.488368572 165918 ring finger protein 168 "GO:0000151,GO:0003682,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006302,GO:0006303,GO:0006511,GO:0006974,GO:0010212,GO:0016567,GO:0031491,GO:0032991,GO:0034244,GO:0035518,GO:0035861,GO:0036297,GO:0036351,GO:0036352,GO:0042393,GO:0043130,GO:0045190,GO:0045739,GO:0046872,GO:0070530,GO:0070534,GO:0070535" ubiquitin ligase complex|chromatin binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|response to ionizing radiation|protein ubiquitination|nucleosome binding|protein-containing complex|negative regulation of transcription elongation from RNA polymerase II promoter|histone H2A monoubiquitination|site of double-strand break|interstrand cross-link repair|histone H2A-K13 ubiquitination|histone H2A-K15 ubiquitination|histone binding|ubiquitin binding|isotype switching|positive regulation of DNA repair|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked ubiquitination|histone H2A K63-linked ubiquitination RNF169 726.1596718 674.945719 777.3736247 1.151757249 0.203836678 0.587956107 1 4.324303555 5.195089774 254225 ring finger protein 169 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006974,GO:0016567,GO:0016604,GO:0016740,GO:0031491,GO:0035861,GO:0046872,GO:0070530,GO:2000780" protein binding|nucleus|nucleoplasm|nucleolus|cytosol|cellular response to DNA damage stimulus|protein ubiquitination|nuclear body|transferase activity|nucleosome binding|site of double-strand break|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|negative regulation of double-strand break repair RNF17 19.45018854 16.23929549 22.66108158 1.395447333 0.480727675 0.696752732 1 0.097171908 0.141439304 56163 ring finger protein 17 "GO:0005634,GO:0005737,GO:0007275,GO:0007283,GO:0030154,GO:0046872" nucleus|cytoplasm|multicellular organism development|spermatogenesis|cell differentiation|metal ion binding RNF170 213.5606405 219.2304892 207.8907919 0.948274999 -0.076622595 0.89309189 1 2.010001969 1.988138856 81790 ring finger protein 170 "GO:0005515,GO:0005789,GO:0016021,GO:0016567,GO:0046872,GO:0061630" protein binding|endoplasmic reticulum membrane|integral component of membrane|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity RNF175 25.03244636 27.40381115 22.66108158 0.826931753 -0.274159827 0.824255662 1 0.433449831 0.373873287 285533 ring finger protein 175 "GO:0000139,GO:0005515,GO:0005789,GO:0016021,GO:0016567,GO:0030433,GO:0030968,GO:0046872,GO:0061630" Golgi membrane|protein binding|endoplasmic reticulum membrane|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|metal ion binding|ubiquitin protein ligase activity RNF180 10.47888836 9.134603715 11.823173 1.294327961 0.372203218 0.848192439 1 0.040082781 0.054115055 285671 ring finger protein 180 "GO:0000209,GO:0005635,GO:0016021,GO:0030534,GO:0031227,GO:0031398,GO:0031624,GO:0032436,GO:0042415,GO:0042428,GO:0046872,GO:0050790,GO:0061630" protein polyubiquitination|nuclear envelope|integral component of membrane|adult behavior|intrinsic component of endoplasmic reticulum membrane|positive regulation of protein ubiquitination|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|norepinephrine metabolic process|serotonin metabolic process|metal ion binding|regulation of catalytic activity|ubiquitin protein ligase activity RNF181 1143.502538 1118.481477 1168.523598 1.044741126 0.063145505 0.856848896 1 20.53920995 22.38248773 51255 ring finger protein 181 "GO:0004842,GO:0005515,GO:0005737,GO:0016567,GO:0046872,GO:0051865,GO:0061630" ubiquitin-protein transferase activity|protein binding|cytoplasm|protein ubiquitination|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity RNF182 88.71289161 70.03196182 107.3938214 1.533497258 0.616825587 0.384383976 1 0.864879739 1.383421932 221687 ring finger protein 182 "GO:0004842,GO:0005515,GO:0005737,GO:0016021,GO:0016567,GO:0046872" ubiquitin-protein transferase activity|protein binding|cytoplasm|integral component of membrane|protein ubiquitination|metal ion binding RNF185 1325.626513 1310.308155 1340.944871 1.023381306 0.033343785 0.923440655 1 20.85558943 22.26259972 91445 ring finger protein 185 "GO:0005515,GO:0005741,GO:0005783,GO:0005789,GO:0006511,GO:0006914,GO:0016021,GO:0030433,GO:0036503,GO:0043130,GO:0044322,GO:0044390,GO:0044877,GO:0046872,GO:0051865,GO:0055085,GO:0061630,GO:0071712,GO:1904294,GO:1904380" protein binding|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|ubiquitin-dependent protein catabolic process|autophagy|integral component of membrane|ubiquitin-dependent ERAD pathway|ERAD pathway|ubiquitin binding|endoplasmic reticulum quality control compartment|ubiquitin-like protein conjugating enzyme binding|protein-containing complex binding|metal ion binding|protein autoubiquitination|transmembrane transport|ubiquitin protein ligase activity|ER-associated misfolded protein catabolic process|positive regulation of ERAD pathway|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum RNF187 3397.224382 3639.632103 3154.816662 0.866795482 -0.206236462 0.516911356 1 59.11947599 53.45189968 149603 ring finger protein 187 "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008284,GO:0010468,GO:0016567,GO:0043161,GO:0045087,GO:0045893,GO:0046872,GO:0051865,GO:0061630,GO:0070936" "ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|positive regulation of cell population proliferation|regulation of gene expression|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|innate immune response|positive regulation of transcription, DNA-templated|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination" RNF19A 1501.834943 1367.145689 1636.524196 1.197037162 0.259467941 0.434067765 1 14.51291263 18.12083241 25897 "ring finger protein 19A, RBR E3 ubiquitin protein ligase" "GO:0000151,GO:0000209,GO:0000226,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0006511,GO:0008134,GO:0016021,GO:0031624,GO:0032436,GO:0046872,GO:0061630,GO:0098686,GO:0098794,GO:0098978,GO:0099576" "ubiquitin ligase complex|protein polyubiquitination|microtubule cytoskeleton organization|protein binding|cytoplasm|centrosome|cytosol|ubiquitin-dependent protein catabolic process|transcription factor binding|integral component of membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity|hippocampal mossy fiber to CA3 synapse|postsynapse|glutamatergic synapse|regulation of protein catabolic process at postsynapse, modulating synaptic transmission" RNF19B 420.4822515 388.7281359 452.2363672 1.163374414 0.21831548 0.612235119 1 4.361477344 5.292599832 127544 ring finger protein 19B "GO:0000151,GO:0000209,GO:0002250,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006511,GO:0016021,GO:0031624,GO:0032436,GO:0042267,GO:0043130,GO:0044194,GO:0046872,GO:0051865,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|adaptive immune response|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|ubiquitin-dependent protein catabolic process|integral component of membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|natural killer cell mediated cytotoxicity|ubiquitin binding|cytolytic granule|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity RNF2 596.5704311 639.4222601 553.7186021 0.86596704 -0.207615979 0.597658667 1 9.048472123 8.17320788 6045 ring finger protein 2 "GO:0000122,GO:0000151,GO:0000278,GO:0000791,GO:0001702,GO:0001739,GO:0003682,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0007281,GO:0008270,GO:0009948,GO:0010467,GO:0016604,GO:0031519,GO:0035102,GO:0035518,GO:0036353,GO:0043433,GO:0061630,GO:0070317,GO:0071339,GO:0071535" negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|mitotic cell cycle|euchromatin|gastrulation with mouth forming second|sex chromatin|chromatin binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|germ cell development|zinc ion binding|anterior/posterior axis specification|gene expression|nuclear body|PcG protein complex|PRC1 complex|histone H2A monoubiquitination|histone H2A-K119 monoubiquitination|negative regulation of DNA-binding transcription factor activity|ubiquitin protein ligase activity|negative regulation of G0 to G1 transition|MLL1 complex|RING-like zinc finger domain binding other RNF20 1177.21605 1234.186458 1120.245642 0.907679415 -0.139745256 0.685085893 1 14.60107221 13.82398216 56254 ring finger protein 20 "GO:0000151,GO:0000209,GO:0002039,GO:0003682,GO:0003713,GO:0003730,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006355,GO:0006511,GO:0007346,GO:0010390,GO:0016567,GO:0030336,GO:0031062,GO:0031625,GO:0033503,GO:0033523,GO:0042393,GO:0042802,GO:0045893,GO:0046872,GO:1900364,GO:2001168" "ubiquitin ligase complex|protein polyubiquitination|p53 binding|chromatin binding|transcription coactivator activity|mRNA 3'-UTR binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|regulation of mitotic cell cycle|histone monoubiquitination|protein ubiquitination|negative regulation of cell migration|positive regulation of histone methylation|ubiquitin protein ligase binding|HULC complex|histone H2B ubiquitination|histone binding|identical protein binding|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of mRNA polyadenylation|positive regulation of histone H2B ubiquitination" RNF207 473.1493605 385.683268 560.615453 1.453564361 0.539594953 0.193137717 1 4.701202627 7.127860084 388591 ring finger protein 207 "GO:0005515,GO:0008270,GO:0010628,GO:0030544,GO:0044325,GO:0048471,GO:0051087,GO:0055117,GO:0086019,GO:1901207,GO:1902261,GO:1903762,GO:1903954" protein binding|zinc ion binding|positive regulation of gene expression|Hsp70 protein binding|ion channel binding|perinuclear region of cytoplasm|chaperone binding|regulation of cardiac muscle contraction|cell-cell signaling involved in cardiac conduction|regulation of heart looping|positive regulation of delayed rectifier potassium channel activity|positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization RNF208 53.48362663 52.77771036 54.18954291 1.026750546 0.038085714 0.988930444 1 0.898791137 0.962586249 727800 ring finger protein 208 "GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0046872,GO:0051865" ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|metal ion binding|protein autoubiquitination RNF213 8297.17247 7629.424014 8964.920926 1.175045575 0.232716714 0.482721222 1 19.27295183 23.62212031 57674 ring finger protein 213 "GO:0000209,GO:0001525,GO:0002040,GO:0004842,GO:0005730,GO:0005737,GO:0005829,GO:0006511,GO:0016020,GO:0016567,GO:0016887,GO:0046872,GO:0051260,GO:0051865,GO:2000051" protein polyubiquitination|angiogenesis|sprouting angiogenesis|ubiquitin-protein transferase activity|nucleolus|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|membrane|protein ubiquitination|ATPase activity|metal ion binding|protein homooligomerization|protein autoubiquitination|negative regulation of non-canonical Wnt signaling pathway RNF214 456.9019002 453.6853179 460.1184825 1.014179795 0.020313437 0.966988874 1 7.528689661 7.964348936 257160 ring finger protein 214 "GO:0004842,GO:0016567,GO:0046872" ubiquitin-protein transferase activity|protein ubiquitination|metal ion binding RNF215 522.8740381 585.6295938 460.1184825 0.785681747 -0.34798305 0.389753215 1 14.74891743 12.08711733 200312 ring finger protein 215 "GO:0005768,GO:0005802,GO:0006511,GO:0006623,GO:0006896,GO:0016020,GO:0016021,GO:0016567,GO:0017119,GO:0046872,GO:0061630" endosome|trans-Golgi network|ubiquitin-dependent protein catabolic process|protein targeting to vacuole|Golgi to vacuole transport|membrane|integral component of membrane|protein ubiquitination|Golgi transport complex|metal ion binding|ubiquitin protein ligase activity RNF216 1322.777362 1283.9193 1361.635424 1.06053038 0.08478595 0.803153354 1 10.24031231 11.32797405 54476 ring finger protein 216 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006915,GO:0016032,GO:0032480,GO:0032648,GO:0043161,GO:0046872,GO:0050691,GO:0061630,GO:0070936,GO:0098685,GO:0098843,GO:0098978,GO:0099546" "protein binding|nucleus|nucleoplasm|cytosol|apoptotic process|viral process|negative regulation of type I interferon production|regulation of interferon-beta production|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|regulation of defense response to virus by host|ubiquitin protein ligase activity|protein K48-linked ubiquitination|Schaffer collateral - CA1 synapse|postsynaptic endocytic zone|glutamatergic synapse|protein catabolic process, modulating synaptic transmission" RNF217 426.2723502 414.1020351 438.4426654 1.058779306 0.082401903 0.851522621 1 1.472395901 1.626095223 154214 ring finger protein 217 "GO:0000151,GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0006511,GO:0016021,GO:0031624,GO:0032436,GO:0046872,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|integral component of membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity RNF220 2059.577988 1810.681448 2308.474528 1.274920296 0.350407058 0.276077993 1 19.77671504 26.29984086 55182 ring finger protein 220 "GO:0004842,GO:0005515,GO:0005737,GO:0016567,GO:0046872,GO:0051865,GO:0061630,GO:0090263" ubiquitin-protein transferase activity|protein binding|cytoplasm|protein ubiquitination|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of canonical Wnt signaling pathway RNF227 49.57226052 54.80762229 44.33689874 0.808954975 -0.305868687 0.734948525 1 0.973969375 0.821836795 284023 ring finger protein 227 GO:0046872 metal ion binding RNF24 1698.737638 1929.431296 1468.043981 0.760868751 -0.394280483 0.227870236 1 11.96362494 9.494857851 11237 ring finger protein 24 "GO:0000139,GO:0005515,GO:0005794,GO:0008270,GO:0012505,GO:0016021,GO:0016567,GO:0061630" Golgi membrane|protein binding|Golgi apparatus|zinc ion binding|endomembrane system|integral component of membrane|protein ubiquitination|ubiquitin protein ligase activity RNF25 446.4378576 445.5656701 447.3100451 1.003914967 0.005637077 0.995401171 1 14.41017199 15.08974925 64320 ring finger protein 25 "GO:0004842,GO:0005515,GO:0005634,GO:0005829,GO:0016567,GO:0046872,GO:0051059,GO:0051092,GO:0061630" ubiquitin-protein transferase activity|protein binding|nucleus|cytosol|protein ubiquitination|metal ion binding|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity RNF26 2228.923217 2004.538038 2453.308397 1.223877198 0.291458808 0.362887464 1 36.47961912 46.56976738 79102 ring finger protein 26 "GO:0005515,GO:0005789,GO:0007032,GO:0008270,GO:0016021,GO:0016567,GO:0032479,GO:0050687,GO:0061630,GO:0070979,GO:1905719" protein binding|endoplasmic reticulum membrane|endosome organization|zinc ion binding|integral component of membrane|protein ubiquitination|regulation of type I interferon production|negative regulation of defense response to virus|ubiquitin protein ligase activity|protein K11-linked ubiquitination|protein localization to perinuclear region of cytoplasm RNF31 956.4373943 925.6398432 987.2349454 1.06654327 0.092942498 0.795802941 1 13.26178008 14.75353976 55072 ring finger protein 31 "GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0007249,GO:0009898,GO:0010803,GO:0023035,GO:0031625,GO:0035631,GO:0042802,GO:0043123,GO:0043130,GO:0046872,GO:0050852,GO:0051092,GO:0071797,GO:0097039,GO:1903955" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|I-kappaB kinase/NF-kappaB signaling|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|CD40 signaling pathway|ubiquitin protein ligase binding|CD40 receptor complex|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|metal ion binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|LUBAC complex|protein linear polyubiquitination|positive regulation of protein targeting to mitochondrion "hsa04217,hsa04621,hsa05131" Necroptosis|NOD-like receptor signaling pathway|Shigellosis RNF32 10.0159477 11.16451565 8.867379749 0.794246703 -0.332340898 0.878848877 1 0.134982891 0.111827876 140545 ring finger protein 32 "GO:0005515,GO:0005768,GO:0005829,GO:0016235,GO:0016604,GO:0046872" protein binding|endosome|cytosol|aggresome|nuclear body|metal ion binding RNF34 1070.182732 1023.075616 1117.289848 1.092089217 0.12709072 0.716872312 1 21.62569731 24.63452364 80196 ring finger protein 34 "GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006511,GO:0006915,GO:0012505,GO:0016567,GO:0016604,GO:0016607,GO:0031625,GO:0035872,GO:0043161,GO:0046872,GO:0061630,GO:0070936,GO:1901797,GO:1901981,GO:1902042,GO:2000374,GO:2001271" "p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|endomembrane system|protein ubiquitination|nuclear body|nuclear speck|ubiquitin protein ligase binding|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of signal transduction by p53 class mediator|phosphatidylinositol phosphate binding|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of oxygen metabolic process|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis" RNF38 874.6131888 956.0885222 793.1378553 0.829565293 -0.269572558 0.455869138 1 7.404053635 6.406724661 152006 ring finger protein 38 "GO:0005515,GO:0005634,GO:0005654,GO:0008584,GO:0016567,GO:0036126,GO:0046872,GO:0061630" protein binding|nucleus|nucleoplasm|male gonad development|protein ubiquitination|sperm flagellum|metal ion binding|ubiquitin protein ligase activity RNF4 1678.6424 1768.053297 1589.231504 0.898859501 -0.153832467 0.639102322 1 24.64107379 23.10294649 6047 ring finger protein 4 "GO:0003677,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008134,GO:0008270,GO:0016604,GO:0016605,GO:0030374,GO:0031491,GO:0032184,GO:0042802,GO:0043161,GO:0045893,GO:0045944,GO:0046685,GO:0051865,GO:0070534,GO:0070936,GO:0070979,GO:0085020,GO:0090169,GO:0090234,GO:1990752" "DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|transcription factor binding|zinc ion binding|nuclear body|PML body|nuclear receptor coactivator activity|nucleosome binding|SUMO polymer binding|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|response to arsenic-containing substance|protein autoubiquitination|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination|regulation of spindle assembly|regulation of kinetochore assembly|microtubule end" RNF40 2213.473224 2362.817494 2064.128953 0.873587976 -0.194975096 0.543104666 1 19.36068121 17.64181289 9810 ring finger protein 40 "GO:0000151,GO:0003730,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0007346,GO:0010390,GO:0016020,GO:0016567,GO:0017075,GO:0019898,GO:0031624,GO:0031625,GO:0033503,GO:0033523,GO:0042803,GO:0043005,GO:0043434,GO:0043679,GO:0044877,GO:0046872,GO:1900364,GO:1901800,GO:1902916,GO:2001168" ubiquitin ligase complex|mRNA 3'-UTR binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of mitotic cell cycle|histone monoubiquitination|membrane|protein ubiquitination|syntaxin-1 binding|extrinsic component of membrane|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|HULC complex|histone H2B ubiquitination|protein homodimerization activity|neuron projection|response to peptide hormone|axon terminus|protein-containing complex binding|metal ion binding|negative regulation of mRNA polyadenylation|positive regulation of proteasomal protein catabolic process|positive regulation of protein polyubiquitination|positive regulation of histone H2B ubiquitination RNF41 1530.469715 1337.711966 1723.227465 1.288190214 0.365345638 0.269423099 1 11.72557839 15.7554278 10193 ring finger protein 41 "GO:0000209,GO:0004842,GO:0005128,GO:0005135,GO:0005515,GO:0005829,GO:0006914,GO:0008270,GO:0008285,GO:0010498,GO:0016567,GO:0019904,GO:0030336,GO:0030971,GO:0031267,GO:0042802,GO:0043408,GO:0045619,GO:0045637,GO:0045732,GO:0048471,GO:0051091,GO:0051865,GO:0051896,GO:0061630,GO:0071782,GO:0097191,GO:1901525,GO:2000114,GO:2000377,GO:2000379" protein polyubiquitination|ubiquitin-protein transferase activity|erythropoietin receptor binding|interleukin-3 receptor binding|protein binding|cytosol|autophagy|zinc ion binding|negative regulation of cell population proliferation|proteasomal protein catabolic process|protein ubiquitination|protein domain specific binding|negative regulation of cell migration|receptor tyrosine kinase binding|small GTPase binding|identical protein binding|regulation of MAPK cascade|regulation of lymphocyte differentiation|regulation of myeloid cell differentiation|positive regulation of protein catabolic process|perinuclear region of cytoplasm|positive regulation of DNA-binding transcription factor activity|protein autoubiquitination|regulation of protein kinase B signaling|ubiquitin protein ligase activity|endoplasmic reticulum tubular network|extrinsic apoptotic signaling pathway|negative regulation of mitophagy|regulation of establishment of cell polarity|regulation of reactive oxygen species metabolic process|positive regulation of reactive oxygen species metabolic process hsa04144 Endocytosis RNF44 746.7517473 600.8539333 892.6495614 1.485634881 0.571079593 0.125653066 1 5.535952708 8.578678428 22838 ring finger protein 44 "GO:0005515,GO:0046872" protein binding|metal ion binding RNF5 979.5020334 919.5501073 1039.453959 1.130394039 0.176825762 0.618329232 1 41.69379495 49.16060449 6048 ring finger protein 5 "GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0006511,GO:0008270,GO:0009617,GO:0010507,GO:0016021,GO:0030433,GO:0031648,GO:0031966,GO:0036503,GO:0042802,GO:0044257,GO:0044322,GO:0044390,GO:0044877,GO:0055085,GO:0061630,GO:0070534,GO:0070936,GO:0071712,GO:1904380,GO:2000785" ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|ubiquitin-dependent protein catabolic process|zinc ion binding|response to bacterium|negative regulation of autophagy|integral component of membrane|ubiquitin-dependent ERAD pathway|protein destabilization|mitochondrial membrane|ERAD pathway|identical protein binding|cellular protein catabolic process|endoplasmic reticulum quality control compartment|ubiquitin-like protein conjugating enzyme binding|protein-containing complex binding|transmembrane transport|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|ER-associated misfolded protein catabolic process|endoplasmic reticulum mannose trimming|regulation of autophagosome assembly hsa04141 Protein processing in endoplasmic reticulum RNF6 782.0483141 892.1462962 671.9503321 0.753184018 -0.408925707 0.267984245 1 10.21339571 8.023930978 6049 ring finger protein 6 "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006511,GO:0016567,GO:0016605,GO:0030424,GO:0030517,GO:0031965,GO:0043231,GO:0044314,GO:0045893,GO:0046872,GO:0050681,GO:0060765,GO:0061630,GO:0070936,GO:0085020" "ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|protein ubiquitination|PML body|axon|negative regulation of axon extension|nuclear membrane|intracellular membrane-bounded organelle|protein K27-linked ubiquitination|positive regulation of transcription, DNA-templated|metal ion binding|androgen receptor binding|regulation of androgen receptor signaling pathway|ubiquitin protein ligase activity|protein K48-linked ubiquitination|protein K6-linked ubiquitination" RNF7 808.3683836 872.8621328 743.8746345 0.85222466 -0.230694297 0.530162529 1 16.60683236 14.76239523 9616 ring finger protein 7 "GO:0005507,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0008270,GO:0016567,GO:0018215,GO:0019788,GO:0031461,GO:0031466,GO:0043687,GO:0045116,GO:0051775,GO:0061630,GO:0061663,GO:0097602" copper ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|protein ubiquitination|protein phosphopantetheinylation|NEDD8 transferase activity|cullin-RING ubiquitin ligase complex|Cul5-RING ubiquitin ligase complex|post-translational protein modification|protein neddylation|response to redox state|ubiquitin protein ligase activity|NEDD8 ligase activity|cullin family protein binding "hsa04120,hsa05170" Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection RNF8 344.2660361 297.3820987 391.1499734 1.315311093 0.395404061 0.383873903 1 6.301821841 8.645906482 9025 ring finger protein 8 "GO:0000151,GO:0000781,GO:0003682,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006302,GO:0006303,GO:0006511,GO:0006974,GO:0007049,GO:0007286,GO:0008270,GO:0010212,GO:0016032,GO:0016567,GO:0030496,GO:0031625,GO:0033522,GO:0033523,GO:0034244,GO:0035093,GO:0035861,GO:0036297,GO:0042393,GO:0042802,GO:0042803,GO:0043130,GO:0043486,GO:0045190,GO:0045739,GO:0051301,GO:0051865,GO:0061630,GO:0070534,GO:0070535,GO:0070936" "ubiquitin ligase complex|chromosome, telomeric region|chromatin binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|cell cycle|spermatid development|zinc ion binding|response to ionizing radiation|viral process|protein ubiquitination|midbody|ubiquitin protein ligase binding|histone H2A ubiquitination|histone H2B ubiquitination|negative regulation of transcription elongation from RNA polymerase II promoter|spermatogenesis, exchange of chromosomal proteins|site of double-strand break|interstrand cross-link repair|histone binding|identical protein binding|protein homodimerization activity|ubiquitin binding|histone exchange|isotype switching|positive regulation of DNA repair|cell division|protein autoubiquitination|ubiquitin protein ligase activity|protein K63-linked ubiquitination|histone H2A K63-linked ubiquitination|protein K48-linked ubiquitination" RNFT1 546.107424 523.7172797 568.4975683 1.0855047 0.118365972 0.770540498 1 12.49973264 14.15299527 51136 "ring finger protein, transmembrane 1" "GO:0005783,GO:0005789,GO:0016021,GO:0043130,GO:0046872,GO:0051865,GO:0061630,GO:1904294" endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|ubiquitin binding|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of ERAD pathway RNFT2 86.44272566 83.22638941 89.65906191 1.07729126 0.107408354 0.895728137 1 1.466639881 1.648058245 84900 "ring finger protein, transmembrane 2" "GO:0016021,GO:0016567,GO:0046872,GO:0061630" integral component of membrane|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity RNGTT 554.5388331 561.2706505 547.8070156 0.976012224 -0.035028879 0.934611889 1 4.863366707 4.95117417 8732 RNA guanylyltransferase and 5'-phosphatase "GO:0004484,GO:0004651,GO:0004725,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0006366,GO:0006370,GO:0006396,GO:0008138,GO:0008192,GO:0016032,GO:0035335,GO:0050355,GO:0098507" mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein binding|GTP binding|nucleus|nucleoplasm|transcription by RNA polymerase II|7-methylguanosine mRNA capping|RNA processing|protein tyrosine/serine/threonine phosphatase activity|RNA guanylyltransferase activity|viral process|peptidyl-tyrosine dephosphorylation|triphosphatase activity|polynucleotide 5' dephosphorylation hsa03015 mRNA surveillance pathway RNH1 2825.747264 2829.69724 2821.797289 0.997208199 -0.00403335 0.991149597 1 56.46736904 58.73531791 6050 ribonuclease/angiogenin inhibitor 1 "GO:0005515,GO:0005654,GO:0005829,GO:0006402,GO:0008428,GO:0032311,GO:0043086,GO:0045765,GO:0070062" protein binding|nucleoplasm|cytosol|mRNA catabolic process|ribonuclease inhibitor activity|angiogenin-PRI complex|negative regulation of catalytic activity|regulation of angiogenesis|extracellular exosome RNLS 4.52276453 6.08973581 2.95579325 0.485372985 -1.042834281 0.660953233 1 0.009271437 0.004693952 55328 "renalase, FAD dependent amine oxidase" "GO:0002931,GO:0005515,GO:0005576,GO:0005615,GO:0010459,GO:0016651,GO:0034356,GO:0045776,GO:0051379,GO:0055114,GO:0070404,GO:0071871,GO:0097621,GO:1902074" "response to ischemia|protein binding|extracellular region|extracellular space|negative regulation of heart rate|oxidoreductase activity, acting on NAD(P)H|NAD biosynthesis via nicotinamide riboside salvage pathway|negative regulation of blood pressure|epinephrine binding|oxidation-reduction process|NADH binding|response to epinephrine|monoamine oxidase activity|response to salt" RNMT 1893.954842 2107.04859 1680.861095 0.797732479 -0.326023078 0.313801767 1 15.15832072 12.61317135 8731 RNA guanine-7 methyltransferase "GO:0001650,GO:0003723,GO:0004482,GO:0005515,GO:0005634,GO:0005654,GO:0005845,GO:0006366,GO:0006370,GO:0031533,GO:0043235,GO:0106005,GO:1990830" fibrillar center|RNA binding|mRNA (guanine-N7-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|mRNA cap binding complex|transcription by RNA polymerase II|7-methylguanosine mRNA capping|mRNA cap methyltransferase complex|receptor complex|RNA 5'-cap (guanine-N7)-methylation|cellular response to leukemia inhibitory factor hsa03015 mRNA surveillance pathway RNPC3 177.794206 198.9313698 156.6570422 0.787492905 -0.34466117 0.541800611 1 4.699240715 3.860026366 55599 "RNA binding region (RNP1, RRM) containing 3" "GO:0000398,GO:0005634,GO:0005654,GO:0005689,GO:0008380,GO:0030626,GO:0097157" "mRNA splicing, via spliceosome|nucleus|nucleoplasm|U12-type spliceosomal complex|RNA splicing|U12 snRNA binding|pre-mRNA intronic binding" RNPEP 1219.197667 1376.280293 1062.115041 0.771728729 -0.373834282 0.273372753 1 27.28130788 21.96068003 6051 arginyl aminopeptidase "GO:0004177,GO:0004301,GO:0005576,GO:0005615,GO:0005886,GO:0006508,GO:0008235,GO:0008270,GO:0070006,GO:0070062" aminopeptidase activity|epoxide hydrolase activity|extracellular region|extracellular space|plasma membrane|proteolysis|metalloexopeptidase activity|zinc ion binding|metalloaminopeptidase activity|extracellular exosome RNPEPL1 973.3677603 904.3257678 1042.409753 1.152692746 0.205008009 0.563555827 1 14.67507525 17.64451913 57140 arginyl aminopeptidase like 1 "GO:0006508,GO:0008270,GO:0070006" proteolysis|zinc ion binding|metalloaminopeptidase activity RNPS1 2603.205921 2535.360009 2671.051833 1.053519746 0.075217355 0.814364931 1 45.32546426 49.80820272 10921 RNA binding protein with serine rich domain 1 "GO:0000184,GO:0000381,GO:0000398,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0035145,GO:0043065,GO:0048025,GO:0061574" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|exon-exon junction complex|positive regulation of apoptotic process|negative regulation of mRNA splicing, via spliceosome|ASAP complex" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway RO60 946.658979 930.714623 962.603335 1.03426261 0.048602547 0.894182326 1 4.834110583 5.215108342 6738 "Ro60, Y RNA binding protein" "GO:0002520,GO:0003723,GO:0005654,GO:0005829,GO:0006383,GO:0007224,GO:0009411,GO:0010468,GO:0030620,GO:0035457,GO:0046872,GO:0060271,GO:1990904" immune system development|RNA binding|nucleoplasm|cytosol|transcription by RNA polymerase III|smoothened signaling pathway|response to UV|regulation of gene expression|U2 snRNA binding|cellular response to interferon-alpha|metal ion binding|cilium assembly|ribonucleoprotein complex hsa05322 Systemic lupus erythematosus ROBO1 1355.223294 1750.799045 959.6475417 0.548119754 -0.867436966 0.01021462 0.428156442 10.80441028 6.177211216 6091 roundabout guidance receptor 1 "GO:0002042,GO:0003148,GO:0003180,GO:0003184,GO:0003272,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006919,GO:0007155,GO:0007156,GO:0007399,GO:0007411,GO:0008046,GO:0009986,GO:0010628,GO:0010629,GO:0016199,GO:0021836,GO:0030275,GO:0030336,GO:0030424,GO:0033116,GO:0033600,GO:0035025,GO:0035385,GO:0035481,GO:0035904,GO:0042802,GO:0043406,GO:0050772,GO:0050925,GO:0060412,GO:0070100,GO:1900748" cell migration involved in sprouting angiogenesis|outflow tract septum morphogenesis|aortic valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion formation|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development|axon guidance|axon guidance receptor activity|cell surface|positive regulation of gene expression|negative regulation of gene expression|axon midline choice point recognition|chemorepulsion involved in postnatal olfactory bulb interneuron migration|LRR domain binding|negative regulation of cell migration|axon|endoplasmic reticulum-Golgi intermediate compartment membrane|negative regulation of mammary gland epithelial cell proliferation|positive regulation of Rho protein signal transduction|Roundabout signaling pathway|positive regulation of Notch signaling pathway involved in heart induction|aorta development|identical protein binding|positive regulation of MAP kinase activity|positive regulation of axonogenesis|negative regulation of negative chemotaxis|ventricular septum morphogenesis|negative regulation of chemokine-mediated signaling pathway|positive regulation of vascular endothelial growth factor signaling pathway hsa04360 Axon guidance ROBO2 98.25105288 82.21143344 114.2906723 1.390204106 0.475296711 0.489953447 1 0.399742615 0.579662153 6092 roundabout guidance receptor 2 "GO:0001656,GO:0001657,GO:0003148,GO:0003180,GO:0003184,GO:0003272,GO:0005515,GO:0005886,GO:0007156,GO:0007411,GO:0007417,GO:0007420,GO:0008046,GO:0009986,GO:0016021,GO:0016199,GO:0021891,GO:0030673,GO:0031290,GO:0032870,GO:0035481,GO:0035904,GO:0042802,GO:0050772,GO:0050925,GO:0051964,GO:0060412,GO:0061364,GO:0070062" metanephros development|ureteric bud development|outflow tract septum morphogenesis|aortic valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion formation|protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|central nervous system development|brain development|axon guidance receptor activity|cell surface|integral component of membrane|axon midline choice point recognition|olfactory bulb interneuron development|axolemma|retinal ganglion cell axon guidance|cellular response to hormone stimulus|positive regulation of Notch signaling pathway involved in heart induction|aorta development|identical protein binding|positive regulation of axonogenesis|negative regulation of negative chemotaxis|negative regulation of synapse assembly|ventricular septum morphogenesis|apoptotic process involved in luteolysis|extracellular exosome hsa04360 Axon guidance ROBO3 735.1809525 618.1081847 852.2537203 1.378809958 0.463423623 0.215230197 1 6.476003103 9.313810324 64221 roundabout guidance receptor 3 "GO:0005515,GO:0005886,GO:0007156,GO:0007411,GO:0016021,GO:0016199,GO:0030424,GO:0061642,GO:0070593,GO:0071679,GO:0098632" protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|integral component of membrane|axon midline choice point recognition|axon|chemoattraction of axon|dendrite self-avoidance|commissural neuron axon guidance|cell-cell adhesion mediator activity hsa04360 Axon guidance ROBO4 24.25502281 41.6131947 6.896850916 0.165737117 -2.593031364 0.020500244 0.616714654 0.501203688 0.086646289 54538 roundabout guidance receptor 4 "GO:0001525,GO:0005515,GO:0005886,GO:0007156,GO:0007411,GO:0016021,GO:0030334,GO:0030424,GO:0038023,GO:0061028,GO:0070062,GO:0070593,GO:0098632" angiogenesis|protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|integral component of membrane|regulation of cell migration|axon|signaling receptor activity|establishment of endothelial barrier|extracellular exosome|dendrite self-avoidance|cell-cell adhesion mediator activity ROCK1 2206.446966 2118.213106 2294.680826 1.08330971 0.115445758 0.719393179 1 11.35719047 12.83333334 6093 Rho associated coiled-coil containing protein kinase 1 "GO:0000139,GO:0000281,GO:0001726,GO:0003180,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005814,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0006915,GO:0006939,GO:0007159,GO:0007165,GO:0007186,GO:0007249,GO:0007266,GO:0010494,GO:0010506,GO:0010508,GO:0010613,GO:0010628,GO:0010951,GO:0016525,GO:0018105,GO:0018107,GO:0019828,GO:0022614,GO:0030027,GO:0030036,GO:0030155,GO:0030334,GO:0030866,GO:0031032,GO:0031175,GO:0032059,GO:0032091,GO:0032956,GO:0034774,GO:0035509,GO:0042326,GO:0043312,GO:0043410,GO:0045616,GO:0045664,GO:0046872,GO:0048010,GO:0048013,GO:0048156,GO:0048598,GO:0050321,GO:0050900,GO:0050901,GO:0051045,GO:0051451,GO:0051492,GO:0051893,GO:0051894,GO:0061157,GO:0070168,GO:0070507,GO:0071559,GO:0072518,GO:0072659,GO:0090521,GO:0097746,GO:0106003,GO:0106310,GO:0106311,GO:0110061,GO:0140058,GO:1900223,GO:1900242,GO:1901888,GO:1902003,GO:1902430,GO:1902992,GO:1903140,GO:1903347,GO:1905205,GO:1990776,GO:2000114,GO:2000145" Golgi membrane|mitotic cytokinesis|ruffle|aortic valve morphogenesis|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|extracellular region|cytoplasm|centriole|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|apoptotic process|smooth muscle contraction|leukocyte cell-cell adhesion|signal transduction|G protein-coupled receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|Rho protein signal transduction|cytoplasmic stress granule|regulation of autophagy|positive regulation of autophagy|positive regulation of cardiac muscle hypertrophy|positive regulation of gene expression|negative regulation of endopeptidase activity|negative regulation of angiogenesis|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|aspartic-type endopeptidase inhibitor activity|membrane to membrane docking|lamellipodium|actin cytoskeleton organization|regulation of cell adhesion|regulation of cell migration|cortical actin cytoskeleton organization|actomyosin structure organization|neuron projection development|bleb|negative regulation of protein binding|regulation of actin cytoskeleton organization|secretory granule lumen|negative regulation of myosin-light-chain-phosphatase activity|negative regulation of phosphorylation|neutrophil degranulation|positive regulation of MAPK cascade|regulation of keratinocyte differentiation|regulation of neuron differentiation|metal ion binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|tau protein binding|embryonic morphogenesis|tau-protein kinase activity|leukocyte migration|leukocyte tethering or rolling|negative regulation of membrane protein ectodomain proteolysis|myoblast migration|regulation of stress fiber assembly|regulation of focal adhesion assembly|positive regulation of focal adhesion assembly|mRNA destabilization|negative regulation of biomineral tissue development|regulation of microtubule cytoskeleton organization|response to transforming growth factor beta|Rho-dependent protein serine/threonine kinase activity|protein localization to plasma membrane|glomerular visceral epithelial cell migration|blood vessel diameter maintenance|amyloid-beta complex|protein serine kinase activity|protein threonine kinase activity|regulation of angiotensin-activated signaling pathway|neuron projection arborization|positive regulation of amyloid-beta clearance|regulation of synaptic vesicle endocytosis|regulation of cell junction assembly|regulation of amyloid-beta formation|negative regulation of amyloid-beta formation|negative regulation of amyloid precursor protein catabolic process|regulation of establishment of endothelial barrier|negative regulation of bicellular tight junction assembly|positive regulation of connective tissue replacement|response to angiotensin|regulation of establishment of cell polarity|regulation of cell motility "hsa04022,hsa04024,hsa04062,hsa04071,hsa04270,hsa04350,hsa04360,hsa04510,hsa04530,hsa04611,hsa04670,hsa04810,hsa04921,hsa05130,hsa05131,hsa05135,hsa05163,hsa05200,hsa05205,hsa05206" cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Vascular smooth muscle contraction|TGF-beta signaling pathway|Axon guidance|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Yersinia infection|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer ROCK2 1809.046921 1690.916643 1927.177199 1.13972336 0.188683688 0.561894956 1 8.558761022 10.17480934 9475 Rho associated coiled-coil containing protein kinase 2 "GO:0000281,GO:0001934,GO:0002931,GO:0003180,GO:0003723,GO:0004674,GO:0005198,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0006939,GO:0007186,GO:0007249,GO:0007266,GO:0010595,GO:0010613,GO:0010628,GO:0010629,GO:0010825,GO:0016525,GO:0018105,GO:0018107,GO:0030155,GO:0030335,GO:0030866,GO:0031032,GO:0031644,GO:0032723,GO:0032956,GO:0035509,GO:0036464,GO:0039694,GO:0042752,GO:0043410,GO:0045019,GO:0045616,GO:0046872,GO:0048010,GO:0048013,GO:0048156,GO:0048511,GO:0048598,GO:0050321,GO:0051246,GO:0051298,GO:0051492,GO:0051496,GO:0051893,GO:0061157,GO:0070168,GO:0071394,GO:0071559,GO:0072518,GO:0072659,GO:0090271,GO:0097746,GO:0106310,GO:0106311,GO:0110061,GO:0150033,GO:1900037,GO:1901888,GO:1902004,GO:1902961,GO:1902966,GO:1902993,GO:1903140,GO:1903347,GO:1905145,GO:1905205,GO:1990776,GO:2000114,GO:2000145" mitotic cytokinesis|positive regulation of protein phosphorylation|response to ischemia|aortic valve morphogenesis|RNA binding|protein serine/threonine kinase activity|structural molecule activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|smooth muscle contraction|G protein-coupled receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|Rho protein signal transduction|positive regulation of endothelial cell migration|positive regulation of cardiac muscle hypertrophy|positive regulation of gene expression|negative regulation of gene expression|positive regulation of centrosome duplication|negative regulation of angiogenesis|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of cell adhesion|positive regulation of cell migration|cortical actin cytoskeleton organization|actomyosin structure organization|regulation of nervous system process|positive regulation of connective tissue growth factor production|regulation of actin cytoskeleton organization|negative regulation of myosin-light-chain-phosphatase activity|cytoplasmic ribonucleoprotein granule|viral RNA genome replication|regulation of circadian rhythm|positive regulation of MAPK cascade|negative regulation of nitric oxide biosynthetic process|regulation of keratinocyte differentiation|metal ion binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|tau protein binding|rhythmic process|embryonic morphogenesis|tau-protein kinase activity|regulation of protein metabolic process|centrosome duplication|regulation of stress fiber assembly|positive regulation of stress fiber assembly|regulation of focal adhesion assembly|mRNA destabilization|negative regulation of biomineral tissue development|cellular response to testosterone stimulus|response to transforming growth factor beta|Rho-dependent protein serine/threonine kinase activity|protein localization to plasma membrane|positive regulation of fibroblast growth factor production|blood vessel diameter maintenance|protein serine kinase activity|protein threonine kinase activity|regulation of angiotensin-activated signaling pathway|negative regulation of protein localization to lysosome|regulation of cellular response to hypoxia|regulation of cell junction assembly|positive regulation of amyloid-beta formation|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of protein localization to early endosome|positive regulation of amyloid precursor protein catabolic process|regulation of establishment of endothelial barrier|negative regulation of bicellular tight junction assembly|cellular response to acetylcholine|positive regulation of connective tissue replacement|response to angiotensin|regulation of establishment of cell polarity|regulation of cell motility "hsa04022,hsa04024,hsa04062,hsa04071,hsa04270,hsa04310,hsa04360,hsa04510,hsa04530,hsa04611,hsa04670,hsa04810,hsa04921,hsa05130,hsa05131,hsa05132,hsa05135,hsa05163,hsa05200,hsa05205" cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Vascular smooth muscle contraction|Wnt signaling pathway|Axon guidance|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer ROGDI 253.7162276 236.4847406 270.9477146 1.145730223 0.196267383 0.698875411 1 8.44053407 10.08714413 79641 rogdi atypical leucine zipper "GO:0005515,GO:0005634,GO:0005635,GO:0007035,GO:0007420,GO:0008021,GO:0008284,GO:0022008,GO:0030097,GO:0030424,GO:0030425,GO:0032502,GO:0042475,GO:0043204,GO:0043291" protein binding|nucleus|nuclear envelope|vacuolar acidification|brain development|synaptic vesicle|positive regulation of cell population proliferation|neurogenesis|hemopoiesis|axon|dendrite|developmental process|odontogenesis of dentin-containing tooth|perikaryon|RAVE complex ROM1 27.51045318 28.41876711 26.60213925 0.936076472 -0.095301701 0.964026605 1 1.059875036 1.034860766 6094 retinal outer segment membrane protein 1 "GO:0005515,GO:0005887,GO:0007155,GO:0007601,GO:0010468,GO:0035845,GO:0042622,GO:0042803,GO:0050908,GO:0051260,GO:0051291,GO:0060219,GO:0061298,GO:1903546" protein binding|integral component of plasma membrane|cell adhesion|visual perception|regulation of gene expression|photoreceptor cell outer segment organization|photoreceptor outer segment membrane|protein homodimerization activity|detection of light stimulus involved in visual perception|protein homooligomerization|protein heterooligomerization|camera-type eye photoreceptor cell differentiation|retina vasculature development in camera-type eye|protein localization to photoreceptor outer segment ROMO1 2162.886007 2305.97996 2019.792054 0.875893151 -0.191173206 0.551487499 1 253.3400216 231.4572898 140823 reactive oxygen species modulator 1 "GO:0003674,GO:0005515,GO:0005739,GO:0005744,GO:0008284,GO:0016021,GO:0030150,GO:0031640,GO:0034614,GO:0042742,GO:0045039,GO:0050829,GO:0050830,GO:0051838,GO:0061844,GO:0090399,GO:2000379" molecular_function|protein binding|mitochondrion|TIM23 mitochondrial import inner membrane translocase complex|positive regulation of cell population proliferation|integral component of membrane|protein import into mitochondrial matrix|killing of cells of other organism|cellular response to reactive oxygen species|defense response to bacterium|protein insertion into mitochondrial inner membrane|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|cytolysis by host of symbiont cells|antimicrobial humoral immune response mediated by antimicrobial peptide|replicative senescence|positive regulation of reactive oxygen species metabolic process ROPN1L 18.165287 29.43372308 6.896850916 0.234317993 -2.093460354 0.077698662 1 0.95253306 0.232809997 83853 rhophilin associated tail protein 1 like "GO:0001932,GO:0003351,GO:0005515,GO:0005576,GO:0005737,GO:0005929,GO:0030317,GO:0031514,GO:0042802,GO:0048240" regulation of protein phosphorylation|epithelial cilium movement involved in extracellular fluid movement|protein binding|extracellular region|cytoplasm|cilium|flagellated sperm motility|motile cilium|identical protein binding|sperm capacitation ROR1 112.0811272 185.7369422 38.42531225 0.206880289 -2.273131901 0.000880826 0.083487487 1.012585671 0.218507738 4919 receptor tyrosine kinase like orphan receptor 1 "GO:0001725,GO:0004714,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007605,GO:0009986,GO:0010976,GO:0014002,GO:0014068,GO:0017147,GO:0018108,GO:0033674,GO:0042813,GO:0043123,GO:0043235,GO:0043410,GO:0043679,GO:0048839,GO:0051092,GO:0060071,GO:0070374,GO:1904929" "stress fiber|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|sensory perception of sound|cell surface|positive regulation of neuron projection development|astrocyte development|positive regulation of phosphatidylinositol 3-kinase signaling|Wnt-protein binding|peptidyl-tyrosine phosphorylation|positive regulation of kinase activity|Wnt-activated receptor activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|positive regulation of MAPK cascade|axon terminus|inner ear development|positive regulation of NF-kappaB transcription factor activity|Wnt signaling pathway, planar cell polarity pathway|positive regulation of ERK1 and ERK2 cascade|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway ROR2 47.11182108 21.31407534 72.90956682 3.420723896 1.774301662 0.044560974 0.958697529 0.142055892 0.50686605 4920 receptor tyrosine kinase like orphan receptor 2 "GO:0001502,GO:0001756,GO:0004714,GO:0005109,GO:0005515,GO:0005524,GO:0005874,GO:0005886,GO:0005887,GO:0007165,GO:0007169,GO:0007223,GO:0007224,GO:0007254,GO:0007275,GO:0008285,GO:0009986,GO:0010976,GO:0014002,GO:0014068,GO:0017147,GO:0018108,GO:0030282,GO:0030335,GO:0030425,GO:0030509,GO:0030538,GO:0030539,GO:0030669,GO:0031435,GO:0033674,GO:0042472,GO:0042733,GO:0043025,GO:0043235,GO:0043410,GO:0043507,GO:0045165,GO:0045651,GO:0045893,GO:0046872,GO:0051968,GO:0060071,GO:0060395,GO:0070374,GO:0090090,GO:0090263,GO:1900020,GO:1904929,GO:1905517" "cartilage condensation|somitogenesis|transmembrane receptor protein tyrosine kinase activity|frizzled binding|protein binding|ATP binding|microtubule|plasma membrane|integral component of plasma membrane|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|Wnt signaling pathway, calcium modulating pathway|smoothened signaling pathway|JNK cascade|multicellular organism development|negative regulation of cell population proliferation|cell surface|positive regulation of neuron projection development|astrocyte development|positive regulation of phosphatidylinositol 3-kinase signaling|Wnt-protein binding|peptidyl-tyrosine phosphorylation|bone mineralization|positive regulation of cell migration|dendrite|BMP signaling pathway|embryonic genitalia morphogenesis|male genitalia development|clathrin-coated endocytic vesicle membrane|mitogen-activated protein kinase kinase kinase binding|positive regulation of kinase activity|inner ear morphogenesis|embryonic digit morphogenesis|neuronal cell body|receptor complex|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|cell fate commitment|positive regulation of macrophage differentiation|positive regulation of transcription, DNA-templated|metal ion binding|positive regulation of synaptic transmission, glutamatergic|Wnt signaling pathway, planar cell polarity pathway|SMAD protein signal transduction|positive regulation of ERK1 and ERK2 cascade|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of protein kinase C activity|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|macrophage migration" hsa04310 Wnt signaling pathway RORA 299.7752363 354.219633 245.3308397 0.692595263 -0.529915575 0.262918684 1 0.692262196 0.500110602 6095 RAR related orphan receptor A "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001222,GO:0001223,GO:0001525,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006367,GO:0006805,GO:0006809,GO:0008013,GO:0008134,GO:0008142,GO:0008270,GO:0008589,GO:0010575,GO:0010906,GO:0019218,GO:0019221,GO:0021702,GO:0021930,GO:0030522,GO:0032922,GO:0036315,GO:0042632,GO:0042692,GO:0042753,GO:0043030,GO:0043124,GO:0043565,GO:0045599,GO:0045893,GO:0045944,GO:0046068,GO:0050728,GO:0070328,GO:0071347,GO:0071356,GO:0071456,GO:0072539,GO:0098531" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription corepressor binding|transcription coactivator binding|angiogenesis|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|xenobiotic metabolic process|nitric oxide biosynthetic process|beta-catenin binding|transcription factor binding|oxysterol binding|zinc ion binding|regulation of smoothened signaling pathway|positive regulation of vascular endothelial growth factor production|regulation of glucose metabolic process|regulation of steroid metabolic process|cytokine-mediated signaling pathway|cerebellar Purkinje cell differentiation|cerebellar granule cell precursor proliferation|intracellular receptor signaling pathway|circadian regulation of gene expression|cellular response to sterol|cholesterol homeostasis|muscle cell differentiation|positive regulation of circadian rhythm|regulation of macrophage activation|negative regulation of I-kappaB kinase/NF-kappaB signaling|sequence-specific DNA binding|negative regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cGMP metabolic process|negative regulation of inflammatory response|triglyceride homeostasis|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to hypoxia|T-helper 17 cell differentiation|ligand-activated transcription factor activity" "hsa04659,hsa04710,hsa05017,hsa05321" Th17 cell differentiation|Circadian rhythm|Spinocerebellar ataxia|Inflammatory bowel disease ROR_rcpt ROS1 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.007698082 0.011692175 6098 "ROS proto-oncogene 1, receptor tyrosine kinase" "GO:0001558,GO:0002066,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005887,GO:0006468,GO:0007169,GO:0007275,GO:0007283,GO:0009986,GO:0010467,GO:0010629,GO:0010966,GO:0016020,GO:0019903,GO:0030154,GO:0032006,GO:0033674,GO:0038083,GO:0043235,GO:0048471,GO:0070372" regulation of cell growth|columnar/cuboidal epithelial cell development|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|spermatogenesis|cell surface|gene expression|negative regulation of gene expression|regulation of phosphate transport|membrane|protein phosphatase binding|cell differentiation|regulation of TOR signaling|positive regulation of kinase activity|peptidyl-tyrosine autophosphorylation|receptor complex|perinuclear region of cytoplasm|regulation of ERK1 and ERK2 cascade RP1 54.00595039 54.80762229 53.20427849 0.970745971 -0.042834281 0.983842172 1 0.197047826 0.199523095 6101 RP1 axonemal microtubule associated "GO:0001750,GO:0001917,GO:0005515,GO:0005874,GO:0005875,GO:0005930,GO:0007601,GO:0007603,GO:0008017,GO:0032391,GO:0035082,GO:0035556,GO:0035845,GO:0042461,GO:0045494,GO:0046548,GO:0046549,GO:0060041,GO:0071482,GO:0097542,GO:1902857" "photoreceptor outer segment|photoreceptor inner segment|protein binding|microtubule|microtubule associated complex|axoneme|visual perception|phototransduction, visible light|microtubule binding|photoreceptor connecting cilium|axoneme assembly|intracellular signal transduction|photoreceptor cell outer segment organization|photoreceptor cell development|photoreceptor cell maintenance|retinal rod cell development|retinal cone cell development|retina development in camera-type eye|cellular response to light stimulus|ciliary tip|positive regulation of non-motile cilium assembly" RP1L1 15.9869173 15.22433953 16.74949508 1.100178767 0.137737964 0.965337596 1 0.096214012 0.110412314 94137 RP1 like 1 "GO:0001750,GO:0005874,GO:0005930,GO:0007601,GO:0032391,GO:0035082,GO:0035556,GO:0042461,GO:0045494,GO:0060041" photoreceptor outer segment|microtubule|axoneme|visual perception|photoreceptor connecting cilium|axoneme assembly|intracellular signal transduction|photoreceptor cell development|photoreceptor cell maintenance|retina development in camera-type eye RP2 560.2304545 512.552764 607.908145 1.186040126 0.24615282 0.537061496 1 7.01594306 8.67963311 6102 RP2 activator of ARL3 GTPase "GO:0000287,GO:0000902,GO:0005096,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005794,GO:0005814,GO:0005886,GO:0005929,GO:0006457,GO:0006892,GO:0007023,GO:0007601,GO:0015031,GO:0016604,GO:0031410,GO:0036064,GO:0043547,GO:0051082,GO:0070062,GO:1990075" magnesium ion binding|cell morphogenesis|GTPase activator activity|protein binding|GTP binding|nucleoplasm|cytoplasm|Golgi apparatus|centriole|plasma membrane|cilium|protein folding|post-Golgi vesicle-mediated transport|post-chaperonin tubulin folding pathway|visual perception|protein transport|nuclear body|cytoplasmic vesicle|ciliary basal body|positive regulation of GTPase activity|unfolded protein binding|extracellular exosome|periciliary membrane compartment RP9 208.3522487 199.9463258 216.7581716 1.084081794 0.116473613 0.834421448 1 5.689087658 6.433104503 6100 RP9 pre-mRNA splicing factor "GO:0003723,GO:0005515,GO:0005634,GO:0005785,GO:0008380,GO:0046872,GO:0050890" RNA binding|protein binding|nucleus|signal recognition particle receptor complex|RNA splicing|metal ion binding|cognition hsa03040 Spliceosome RPA1 3451.226373 3559.450581 3343.002165 0.939190498 -0.090510282 0.776580395 1 52.72700057 51.65384877 6117 replication protein A1 "GO:0000082,GO:0000723,GO:0000724,GO:0000781,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0006260,GO:0006261,GO:0006268,GO:0006281,GO:0006283,GO:0006284,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006297,GO:0006298,GO:0006310,GO:0006974,GO:0007004,GO:0016605,GO:0019985,GO:0032201,GO:0033683,GO:0034502,GO:0036297,GO:0042276,GO:0042769,GO:0043047,GO:0046872,GO:0051321,GO:0070987,GO:0090734,GO:0098505,GO:1900034,GO:1901796" "G1/S transition of mitotic cell cycle|telomere maintenance|double-strand break repair via homologous recombination|chromosome, telomeric region|damaged DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|DNA replication|DNA-dependent DNA replication|DNA unwinding involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|DNA recombination|cellular response to DNA damage stimulus|telomere maintenance via telomerase|PML body|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|protein localization to chromosome|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|single-stranded telomeric DNA binding|metal ion binding|meiotic cell cycle|error-free translesion synthesis|site of DNA damage|G-rich strand telomeric DNA binding|regulation of cellular response to heat|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430,hsa03440,hsa03460" DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPA2 800.2393333 788.6207874 811.8578792 1.029465482 0.041895458 0.912574919 1 21.450516 23.03379318 6118 replication protein A2 "GO:0000082,GO:0000723,GO:0000724,GO:0000781,GO:0000785,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0006260,GO:0006283,GO:0006284,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006297,GO:0006298,GO:0010569,GO:0016604,GO:0016605,GO:0019899,GO:0019903,GO:0019985,GO:0031571,GO:0031625,GO:0032201,GO:0033683,GO:0034502,GO:0035861,GO:0036297,GO:0042276,GO:0042769,GO:0047485,GO:0070987,GO:0098505,GO:1900034,GO:1901796,GO:2000001" "G1/S transition of mitotic cell cycle|telomere maintenance|double-strand break repair via homologous recombination|chromosome, telomeric region|chromatin|damaged DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|DNA replication|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|regulation of double-strand break repair via homologous recombination|nuclear body|PML body|enzyme binding|protein phosphatase binding|translesion synthesis|mitotic G1 DNA damage checkpoint|ubiquitin protein ligase binding|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|protein localization to chromosome|site of double-strand break|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|protein N-terminus binding|error-free translesion synthesis|G-rich strand telomeric DNA binding|regulation of cellular response to heat|regulation of signal transduction by p53 class mediator|regulation of DNA damage checkpoint" "hsa03030,hsa03420,hsa03430,hsa03440,hsa03460" DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPA3 867.5045376 806.8899949 928.1190804 1.150242395 0.201937918 0.577723732 1 20.23075827 24.27266496 6119 replication protein A3 "GO:0000082,GO:0000723,GO:0000724,GO:0003684,GO:0003697,GO:0005515,GO:0005654,GO:0005662,GO:0006260,GO:0006283,GO:0006284,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006297,GO:0006298,GO:0007346,GO:0019985,GO:0032201,GO:0033683,GO:0035861,GO:0036297,GO:0042127,GO:0042276,GO:0042769,GO:0070987,GO:1900034,GO:1901796" "G1/S transition of mitotic cell cycle|telomere maintenance|double-strand break repair via homologous recombination|damaged DNA binding|single-stranded DNA binding|protein binding|nucleoplasm|DNA replication factor A complex|DNA replication|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|regulation of mitotic cell cycle|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|site of double-strand break|interstrand cross-link repair|regulation of cell population proliferation|error-prone translesion synthesis|DNA damage response, detection of DNA damage|error-free translesion synthesis|regulation of cellular response to heat|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430,hsa03440,hsa03460" DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPAIN 658.8823433 622.1680086 695.5966781 1.118020645 0.160946828 0.676302374 1 12.887777 15.02947345 84268 RPA interacting protein "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006261,GO:0006281,GO:0006310,GO:0006606,GO:0016605,GO:0044877,GO:0046872" fibrillar center|protein binding|nucleus|nucleoplasm|cytoplasm|DNA-dependent DNA replication|DNA repair|DNA recombination|protein import into nucleus|PML body|protein-containing complex binding|metal ion binding RPAP1 638.2808653 628.2577444 648.3039861 1.031907671 0.045313893 0.910448453 1 6.403509437 6.892469052 26015 RNA polymerase II associated protein 1 "GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0006366" DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|transcription by RNA polymerase II RPAP2 482.2757994 504.4331163 460.1184825 0.912149634 -0.132657583 0.751187301 1 1.193653124 1.135690929 79871 RNA polymerase II associated protein 2 "GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0008420,GO:0009301,GO:0016591,GO:0042795,GO:0043175,GO:0046872,GO:0070940,GO:0106306,GO:0106307" "protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|RNA polymerase II CTD heptapeptide repeat phosphatase activity|snRNA transcription|RNA polymerase II, holoenzyme|snRNA transcription by RNA polymerase II|RNA polymerase core enzyme binding|metal ion binding|dephosphorylation of RNA polymerase II C-terminal domain|protein serine phosphatase activity|protein threonine phosphatase activity" RPAP3 726.3378211 687.1251906 765.5504517 1.114135331 0.155924484 0.679384862 1 8.02038877 9.320716456 79657 RNA polymerase II associated protein 3 "GO:0005515,GO:0005829,GO:0097255" protein binding|cytosol|R2TP complex RPE 1037.230314 1094.122534 980.3380945 0.896003934 -0.158423029 0.652315671 1 12.21906207 11.41993724 6120 ribulose-5-phosphate-3-epimerase "GO:0004750,GO:0005515,GO:0005829,GO:0005975,GO:0006098,GO:0009052,GO:0019323,GO:0042802,GO:0042803,GO:0044262,GO:0046872,GO:0070062" "ribulose-phosphate 3-epimerase activity|protein binding|cytosol|carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|pentose catabolic process|identical protein binding|protein homodimerization activity|cellular carbohydrate metabolic process|metal ion binding|extracellular exosome" "hsa00030,hsa00040" Pentose phosphate pathway|Pentose and glucuronate interconversions RPEL1 7.47855778 6.08973581 8.867379749 1.456118956 0.542128219 0.797747104 1 0.144799829 0.219928157 729020 ribulose-5-phosphate-3-epimerase like 1 "GO:0004750,GO:0005829,GO:0006098,GO:0009052,GO:0019323,GO:0044262,GO:0046872" "ribulose-phosphate 3-epimerase activity|cytosol|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|pentose catabolic process|cellular carbohydrate metabolic process|metal ion binding" "hsa00030,hsa00040" Pentose phosphate pathway|Pentose and glucuronate interconversions RPF1 693.4799209 697.2747503 689.6850916 0.989115254 -0.015789458 0.970911794 1 18.12859664 18.70367792 80135 ribosome production factor 1 homolog "GO:0000460,GO:0000470,GO:0003723,GO:0005515,GO:0005730,GO:0006364,GO:0019843,GO:0030687" "maturation of 5.8S rRNA|maturation of LSU-rRNA|RNA binding|protein binding|nucleolus|rRNA processing|rRNA binding|preribosome, large subunit precursor" RPF2 341.3290479 433.3861985 249.2718974 0.575172671 -0.797932966 0.079686085 1 4.953618158 2.971917156 84154 ribosome production factor 2 homolog "GO:0000027,GO:0000463,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0008097,GO:0019843,GO:0042273,GO:1901796,GO:1902570" "ribosomal large subunit assembly|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|5S rRNA binding|rRNA binding|ribosomal large subunit biogenesis|regulation of signal transduction by p53 class mediator|protein localization to nucleolus" RPGR 289.0966719 230.3950048 347.798339 1.50957413 0.594141605 0.214712209 1 1.999776214 3.14884855 6103 retinitis pigmentosa GTPase regulator "GO:0001750,GO:0003723,GO:0005085,GO:0005515,GO:0005794,GO:0005813,GO:0006886,GO:0007601,GO:0036064,GO:0036126,GO:0042073,GO:0050790,GO:0050896,GO:0060271" photoreceptor outer segment|RNA binding|guanyl-nucleotide exchange factor activity|protein binding|Golgi apparatus|centrosome|intracellular protein transport|visual perception|ciliary basal body|sperm flagellum|intraciliary transport|regulation of catalytic activity|response to stimulus|cilium assembly RPGRIP1L 291.806768 314.6363502 268.9771857 0.854882742 -0.226201546 0.638972248 1 1.05888904 0.944219429 23322 RPGRIP1 like "GO:0001701,GO:0001736,GO:0001822,GO:0001889,GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005879,GO:0005886,GO:0005911,GO:0005923,GO:0005929,GO:0005930,GO:0007163,GO:0007368,GO:0008589,GO:0021532,GO:0021549,GO:0021670,GO:0021772,GO:0022038,GO:0031870,GO:0032391,GO:0035115,GO:0035116,GO:0035253,GO:0035869,GO:0036064,GO:0043584,GO:0045744,GO:0046548,GO:0060039,GO:0090102,GO:0097711,GO:1905515" in utero embryonic development|establishment of planar polarity|kidney development|liver development|protein binding|nucleoplasm|cytoplasm|centrosome|cytosol|axonemal microtubule|plasma membrane|cell-cell junction|bicellular tight junction|cilium|axoneme|establishment or maintenance of cell polarity|determination of left/right symmetry|regulation of smoothened signaling pathway|neural tube patterning|cerebellum development|lateral ventricle development|olfactory bulb development|corpus callosum development|thromboxane A2 receptor binding|photoreceptor connecting cilium|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|ciliary rootlet|ciliary transition zone|ciliary basal body|nose development|negative regulation of G protein-coupled receptor signaling pathway|retinal rod cell development|pericardium development|cochlea development|ciliary basal body-plasma membrane docking|non-motile cilium assembly RPH3AL 85.26446615 70.03196182 100.4969705 1.435015782 0.521066604 0.470074241 1 1.304476575 1.952580249 9501 rabphilin 3A like (without C2 domains) "GO:0005515,GO:0005737,GO:0006886,GO:0006887,GO:0008092,GO:0017157,GO:0030274,GO:0030658,GO:0030667,GO:0042493,GO:0046872,GO:0050714" protein binding|cytoplasm|intracellular protein transport|exocytosis|cytoskeletal protein binding|regulation of exocytosis|LIM domain binding|transport vesicle membrane|secretory granule membrane|response to drug|metal ion binding|positive regulation of protein secretion RPIA 408.6536353 455.7152298 361.5920409 0.793460515 -0.333769663 0.439840231 1 12.73048468 10.53625294 22934 ribose 5-phosphate isomerase A "GO:0004751,GO:0005515,GO:0005829,GO:0006014,GO:0006098,GO:0009052,GO:0019693,GO:0042802,GO:0043231,GO:0048029" "ribose-5-phosphate isomerase activity|protein binding|cytosol|D-ribose metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|ribose phosphate metabolic process|identical protein binding|intracellular membrane-bounded organelle|monosaccharide binding" hsa00030 Pentose phosphate pathway RPL10 31011.27383 29373.84068 32648.70697 1.11148921 0.152493943 0.696876632 1 599.1467603 694.6313759 6134 ribosomal protein L10 "GO:0000027,GO:0000122,GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005783,GO:0005790,GO:0005829,GO:0006412,GO:0006413,GO:0006417,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0032991,GO:0043066,GO:0045182,GO:1990403" "ribosomal large subunit assembly|negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|endoplasmic reticulum|smooth endoplasmic reticulum|cytosol|translation|translational initiation|regulation of translation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|protein-containing complex|negative regulation of apoptotic process|translation regulator activity|embryonic brain development" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL10A 10467.23022 10594.1104 10340.35005 0.976047036 -0.034977422 0.917777096 1 549.1855864 559.1210037 4736 ribosomal protein L10a "GO:0000184,GO:0000470,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of LSU-rRNA|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL11 9941.000795 10149.55968 9732.441907 0.95890287 -0.060543407 0.857330684 1 492.374897 492.4775652 6135 ribosomal protein L11 "GO:0000027,GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006605,GO:0006614,GO:0008097,GO:0010628,GO:0016020,GO:0019083,GO:0022625,GO:0031625,GO:0032092,GO:0032435,GO:0032991,GO:0034504,GO:0042273,GO:0042788,GO:0050821,GO:0070062,GO:1901796,GO:1902255,GO:1904667,GO:1990948,GO:2000059,GO:2000435" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|translation|translational initiation|protein targeting|SRP-dependent cotranslational protein targeting to membrane|5S rRNA binding|positive regulation of gene expression|membrane|viral transcription|cytosolic large ribosomal subunit|ubiquitin protein ligase binding|positive regulation of protein binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|protein localization to nucleus|ribosomal large subunit biogenesis|polysomal ribosome|protein stabilization|extracellular exosome|regulation of signal transduction by p53 class mediator|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of ubiquitin protein ligase activity|ubiquitin ligase inhibitor activity|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of protein neddylation" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL12 17308.96896 17906.86815 16711.06977 0.933221244 -0.099708946 0.779839521 1 1430.472713 1392.45165 6136 ribosomal protein L12 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0015934,GO:0016020,GO:0019083,GO:0022625,GO:0070062,GO:0070180" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|large ribosomal subunit|membrane|viral transcription|cytosolic large ribosomal subunit|extracellular exosome|large ribosomal subunit rRNA binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL13 21941.46427 20956.81083 22926.11771 1.093969779 0.129572884 0.725339502 1 224.5849635 256.2724555 6137 ribosomal protein L13 "GO:0000184,GO:0001824,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0022626,GO:0060348" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|blastocyst development|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|cytosolic ribosome|bone development" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL13A 34844.35054 33476.2927 36212.40837 1.081732935 0.113344362 0.776838526 1 1517.865827 1712.652945 23521 ribosomal protein L13a "GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0015934,GO:0016020,GO:0017148,GO:0019083,GO:0022625,GO:0071346,GO:0097452,GO:1901194,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|nucleus|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|large ribosomal subunit|membrane|negative regulation of translation|viral transcription|cytosolic large ribosomal subunit|cellular response to interferon-gamma|GAIT complex|negative regulation of formation of translation preinitiation complex|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL14 13920.04534 13891.70234 13948.38835 1.004080566 0.005875033 0.986737416 1 100.1517034 104.8921123 9045 ribosomal protein L14 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0042273,GO:0045296,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|cadherin binding|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL15 38692.11887 37000.21983 40384.01791 1.091453459 0.126250613 0.756748824 1 317.0242946 360.9222832 6138 ribosomal protein L15 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0031672,GO:0045296,GO:0045471" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|ribosome|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|A band|cadherin binding|response to ethanol" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL17 167.3774224 160.363043 174.3918017 1.087481245 0.120990521 0.841412143 1 7.691119698 8.724233405 6139 ribosomal protein L17 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL18 10102.27537 9724.293133 10480.2576 1.077739786 0.10800889 0.748525054 1 765.942678 861.0455254 6141 ribosomal protein L18 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005783,GO:0005791,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|endoplasmic reticulum|rough endoplasmic reticulum|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL18A 13181.58719 13554.73696 12808.43742 0.944941791 -0.081702634 0.81312932 1 1082.806954 1067.264398 6142 ribosomal protein L18a "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL19 25348.12439 26420.31881 24275.92996 0.918835618 -0.122121312 0.746332481 1 1185.204555 1135.918214 6143 ribosomal protein L19 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005730,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleolus|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL21 6757.702755 6821.519063 6693.886446 0.981289707 -0.027248967 0.933978838 1 610.3990737 624.7798856 6144 ribosomal protein L21 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL22 7187.432687 7674.082077 6700.783297 0.873170658 -0.195664444 0.551025813 1 188.5808756 171.7563139 6146 ribosomal protein L22 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0008201,GO:0019083,GO:0022625,GO:0042802,GO:0045182,GO:0046632,GO:0070062,GO:0098793,GO:0098978,GO:0099577,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytoplasm|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|heparin binding|viral transcription|cytosolic large ribosomal subunit|identical protein binding|translation regulator activity|alpha-beta T cell differentiation|extracellular exosome|presynapse|glutamatergic synapse|regulation of translation at presynapse, modulating synaptic transmission|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL22L1 301.7215168 285.2026271 318.2404065 1.115839674 0.158129753 0.742476736 1 7.594377986 8.839138474 200916 ribosomal protein L22 like 1 "GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005840" cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|ribosome "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL23 11814.56076 12108.4247 11520.69682 0.951461243 -0.071783204 0.833710314 1 226.6256449 224.9137907 9349 ribosomal protein L23 "GO:0000122,GO:0000184,GO:0001223,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006610,GO:0006614,GO:0008284,GO:0010628,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0031625,GO:0032986,GO:0032991,GO:0050821,GO:0070062,GO:0070180,GO:0071157,GO:0071158,GO:0072717,GO:1901798,GO:1904667,GO:1990948,GO:2000059" "negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|transcription coactivator binding|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|translation|translational initiation|ribosomal protein import into nucleus|SRP-dependent cotranslational protein targeting to membrane|positive regulation of cell population proliferation|positive regulation of gene expression|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|ubiquitin protein ligase binding|protein-DNA complex disassembly|protein-containing complex|protein stabilization|extracellular exosome|large ribosomal subunit rRNA binding|negative regulation of cell cycle arrest|positive regulation of cell cycle arrest|cellular response to actinomycin D|positive regulation of signal transduction by p53 class mediator|negative regulation of ubiquitin protein ligase activity|ubiquitin ligase inhibitor activity|negative regulation of ubiquitin-dependent protein catabolic process" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL23A 23875.49899 23278.01513 24472.98284 1.051334605 0.072221904 0.846822791 1 1215.411698 1332.847007 6147 ribosomal protein L23a "GO:0000027,GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0019843,GO:0022625,GO:0045296,GO:0070062,GO:1904841" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|cytoplasm|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|rRNA binding|cytosolic large ribosomal subunit|cadherin binding|extracellular exosome|TORC2 complex binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL24 6270.84184 6710.888863 5830.794817 0.868855816 -0.202811309 0.532978952 1 606.9336541 550.0534104 6152 ribosomal protein L24 "GO:0000027,GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0010458,GO:0016020,GO:0019083,GO:0021554,GO:0022625,GO:0031290,GO:0042788,GO:0045202,GO:0045296,GO:0060041,GO:0070062,GO:1902626" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytoplasm|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|exit from mitosis|membrane|viral transcription|optic nerve development|cytosolic large ribosomal subunit|retinal ganglion cell axon guidance|polysomal ribosome|synapse|cadherin binding|retina development in camera-type eye|extracellular exosome|assembly of large subunit precursor of preribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL26 16590.16017 16420.97261 16759.34773 1.020606277 0.02942642 0.934030793 1 919.9826694 979.3858182 6154 ribosomal protein L26 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0006977,GO:0016020,GO:0019083,GO:0022625,GO:0022626,GO:0034644,GO:0042273,GO:0045727,GO:0048027,GO:0070062,GO:0071480,GO:1902164,GO:1902167,GO:1904803,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|membrane|viral transcription|cytosolic large ribosomal subunit|cytosolic ribosome|cellular response to UV|ribosomal large subunit biogenesis|positive regulation of translation|mRNA 5'-UTR binding|extracellular exosome|cellular response to gamma radiation|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of translation involved in cellular response to UV|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL26L1 951.3989869 1019.015792 883.7821816 0.867289976 -0.20541366 0.564374317 1 29.62661022 26.80169251 51121 ribosomal protein L26 like 1 "GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0022625,GO:0042273,GO:0070062" cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|extracellular exosome "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL27 17642.85731 18235.71388 17050.00073 0.934978517 -0.096994878 0.786206099 1 1425.269408 1389.999121 6155 ribosomal protein L27 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0070062,GO:0098556,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|extracellular exosome|cytoplasmic side of rough endoplasmic reticulum membrane|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL27A 20228.10207 20250.40148 20205.80265 0.997797632 -0.003180849 0.993185393 1 226.1546628 235.3769577 6157 ribosomal protein L27a "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL28 15876.3883 15043.67736 16709.09924 1.110705769 0.151476691 0.667676448 1 141.3298437 163.7377568 6158 ribosomal protein L28 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0030425,GO:0036464,GO:0044297,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|dendrite|cytoplasmic ribonucleoprotein granule|cell body|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL29 13372.04137 13743.51877 13000.56398 0.945941443 -0.080177216 0.816831439 1 663.5469412 654.7143114 6159 ribosomal protein L29 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0007566,GO:0008201,GO:0016020,GO:0019083,GO:0022625,GO:0045296" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|embryo implantation|heparin binding|membrane|viral transcription|cytosolic large ribosomal subunit|cadherin binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL3 36286.96347 36149.68673 36424.24022 1.007594906 0.010915734 0.978451899 1 1412.696068 1484.740754 6122 ribosomal protein L3 "GO:0000027,GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0008097,GO:0019083,GO:0022625,GO:0032991,GO:0045202,GO:0070062,GO:0071353" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|cytoplasm|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|5S rRNA binding|viral transcription|cytosolic large ribosomal subunit|protein-containing complex|synapse|extracellular exosome|cellular response to interleukin-4" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL30 20453.38468 20429.03373 20477.73563 1.002383955 0.003435227 0.992639008 1 2077.627488 2172.289579 6156 ribosomal protein L30 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0031640,GO:0035368,GO:0042788,GO:0050829,GO:0061844,GO:0070062,GO:0097421,GO:1904571" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|killing of cells of other organism|selenocysteine insertion sequence binding|polysomal ribosome|defense response to Gram-negative bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome|liver regeneration|positive regulation of selenocysteine incorporation" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL31 7345.63146 7072.213188 7619.049733 1.077321841 0.107449308 0.743857169 1 156.0028958 175.3048996 6160 ribosomal protein L31 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL32 21352.84326 20591.42669 22114.25983 1.073954717 0.102933164 0.779296257 1 449.7124275 503.7752057 6161 ribosomal protein L32 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL34 3071.177819 3072.271716 3070.083922 0.99928789 -0.001027723 0.998597249 1 124.5794428 129.8532843 6164 ribosomal protein L34 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625,GO:0045296,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|cadherin binding|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL35 9592.428 9759.816592 9425.039409 0.965698415 -0.050355386 0.880853149 1 1093.58469 1101.564343 11224 ribosomal protein L35 "GO:0000184,GO:0000463,GO:0003723,GO:0003729,GO:0003735,GO:0005730,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|mRNA binding|structural constituent of ribosome|nucleolus|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL35A 7595.014951 7719.755095 7470.274806 0.967682875 -0.047393764 0.885906029 1 316.8382187 319.8059564 6165 ribosomal protein L35a "GO:0000049,GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042273,GO:0070062" "tRNA binding|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL36 6098.105093 6184.126715 6012.08347 0.972179864 -0.040704842 0.900671822 1 515.9871529 523.2406062 25873 ribosomal protein L36 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005730,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|nucleolus|cytoplasm|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL36A 7.000771347 7.104691779 6.896850916 0.970745971 -0.042834281 1 1 0.472835184 0.47877483 6173 ribosomal protein L36a "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005783,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|endoplasmic reticulum|cytosol|ribosome|plasma membrane|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL36AL 2564.947872 2681.513668 2448.382075 0.913059704 -0.131218896 0.681271492 1 200.9011945 191.3364117 6166 ribosomal protein L36a like "GO:0003735,GO:0005515,GO:0005634,GO:0005783,GO:0005829,GO:0005886,GO:0006412,GO:0022625" structural constituent of ribosome|protein binding|nucleus|endoplasmic reticulum|cytosol|plasma membrane|translation|cytosolic large ribosomal subunit "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL37 16114.2297 17192.33915 15036.12026 0.874582576 -0.193333488 0.584394258 1 114.9783873 104.889729 6167 ribosomal protein L37 "GO:0000184,GO:0003723,GO:0003735,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0019843,GO:0022625,GO:0045202,GO:0046872" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|rRNA binding|cytosolic large ribosomal subunit|synapse|metal ion binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL37A 10826.1186 10981.82358 10670.41363 0.971643148 -0.041501537 0.902735814 1 185.8925878 188.4016905 6168 ribosomal protein L37a "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625,GO:0046872,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|metal ion binding|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL38 6393.149723 6518.047229 6268.252218 0.961676404 -0.056376574 0.862913675 1 297.40189 298.3242887 6169 ribosomal protein L38 "GO:0000184,GO:0001501,GO:0001503,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006417,GO:0006614,GO:0007605,GO:0014069,GO:0019083,GO:0022618,GO:0022625,GO:0033291,GO:0034463,GO:0042474,GO:0042788,GO:0048318" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|skeletal system development|ossification|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|regulation of translation|SRP-dependent cotranslational protein targeting to membrane|sensory perception of sound|postsynaptic density|viral transcription|ribonucleoprotein complex assembly|cytosolic large ribosomal subunit|eukaryotic 80S initiation complex|90S preribosome assembly|middle ear morphogenesis|polysomal ribosome|axial mesoderm development" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL39 12004.73485 11335.02825 12674.44145 1.118165846 0.161134184 0.637725605 1 1471.997932 1716.838138 6170 ribosomal protein L39 "GO:0000184,GO:0002181,GO:0002227,GO:0003723,GO:0003735,GO:0005615,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0019731,GO:0022625,GO:0042788,GO:0050830,GO:0061844" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|innate immune response in mucosa|RNA binding|structural constituent of ribosome|extracellular space|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|antibacterial humoral response|cytosolic large ribosomal subunit|polysomal ribosome|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL39L 329.6558165 241.5595205 417.7521126 1.729396183 0.79026841 0.085965108 1 16.78208168 30.27305543 116832 ribosomal protein L39 like "GO:0003735,GO:0005515,GO:0006412,GO:0007283,GO:0022625" structural constituent of ribosome|protein binding|translation|spermatogenesis|cytosolic large ribosomal subunit RPL4 26553.25988 25589.06987 27517.44989 1.07535952 0.10481907 0.78299757 1 472.8187218 530.3520823 6124 ribosomal protein L4 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005791,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0070062,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|cytoplasm|rough endoplasmic reticulum|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL41 15624.10742 15882.03099 15366.18384 0.967520076 -0.047636497 0.89251001 1 1433.812551 1446.999207 6171 ribosomal protein L41 "GO:0000184,GO:0002181,GO:0003723,GO:0003730,GO:0003735,GO:0005515,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625,GO:0042788,GO:0048027" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|mRNA 3'-UTR binding|structural constituent of ribosome|protein binding|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome|mRNA 5'-UTR binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL5 17890.17896 18169.74175 17610.61618 0.969227655 -0.045092525 0.899924338 1 895.1685996 904.9958065 6125 ribosomal protein L5 "GO:0000027,GO:0000184,GO:0003723,GO:0003730,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008097,GO:0010628,GO:0016020,GO:0019083,GO:0022625,GO:0031625,GO:0032991,GO:0042273,GO:0045727,GO:0048027,GO:0050821,GO:0070062,GO:1901796,GO:1904667,GO:1990904,GO:1990948,GO:2000059,GO:2000435" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA 3'-UTR binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|5S rRNA binding|positive regulation of gene expression|membrane|viral transcription|cytosolic large ribosomal subunit|ubiquitin protein ligase binding|protein-containing complex|ribosomal large subunit biogenesis|positive regulation of translation|mRNA 5'-UTR binding|protein stabilization|extracellular exosome|regulation of signal transduction by p53 class mediator|negative regulation of ubiquitin protein ligase activity|ribonucleoprotein complex|ubiquitin ligase inhibitor activity|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of protein neddylation" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL6 16595.086 17161.89047 16028.28153 0.93394615 -0.098588726 0.781113767 1 284.5136526 277.1665889 6128 ribosomal protein L6 "GO:0000027,GO:0000184,GO:0002181,GO:0003677,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005791,GO:0005829,GO:0005925,GO:0006355,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0036464,GO:0042788,GO:0045296" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|DNA binding|RNA binding|structural constituent of ribosome|protein binding|nucleus|rough endoplasmic reticulum|cytosol|focal adhesion|regulation of transcription, DNA-templated|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|cytoplasmic ribonucleoprotein granule|polysomal ribosome|cadherin binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL7 22492.93869 22487.36444 22498.51295 1.000495768 0.000715065 0.998596719 1 620.9954624 648.0665598 6129 ribosomal protein L7 "GO:0000184,GO:0000463,GO:0003677,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0042273,GO:0042802,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA binding|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|cytoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|identical protein binding|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL7A 27744.29166 28205.62636 27282.95696 0.967287753 -0.047982961 0.900498905 1 1610.502223 1624.923605 6130 ribosomal protein L7a "GO:0000184,GO:0000470,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788,GO:0045202,GO:0045296" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of LSU-rRNA|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|cytoplasm|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome|synapse|cadherin binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL7L1 2776.297729 2917.998409 2634.59705 0.902878165 -0.147396772 0.64387939 1 38.78906177 36.5303939 285855 ribosomal protein L7 like 1 "GO:0000463,GO:0001825,GO:0003723,GO:0003735,GO:0005515,GO:0005730,GO:0022625" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|blastocyst formation|RNA binding|structural constituent of ribosome|protein binding|nucleolus|cytosolic large ribosomal subunit" RPL8 47189.43041 45413.18985 48965.67097 1.078225756 0.108659278 0.797094514 1 2149.5494 2417.536623 6132 ribosomal protein L8 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0042788,GO:0098794,GO:1990090,GO:1990932" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome|postsynapse|cellular response to nerve growth factor stimulus|5.8S rRNA binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL9 6690.276969 6758.591793 6621.962144 0.979784302 -0.029463918 0.928542321 1 388.0939132 396.6278796 6133 ribosomal protein L9 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0019843,GO:0022625" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|rRNA binding|cytosolic large ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPLP0 48717.56686 46254.58835 51180.54538 1.106496614 0.145999036 0.731265646 1 2010.842681 2320.83419 6175 ribosomal protein lateral stalk subunit P0 "GO:0000027,GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0030425,GO:0035722,GO:0036464,GO:0070062,GO:0070180,GO:0071353,GO:0098794,GO:1990904" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|dendrite|interleukin-12-mediated signaling pathway|cytoplasmic ribonucleoprotein granule|extracellular exosome|large ribosomal subunit rRNA binding|cellular response to interleukin-4|postsynapse|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPLP1 25149.18608 24270.64207 26027.73009 1.072395613 0.100837223 0.789127751 1 1047.037819 1171.206104 6176 ribosomal protein lateral stalk subunit P1 "GO:0000184,GO:0002181,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006414,GO:0006614,GO:0019083,GO:0022625,GO:0030295,GO:0032147,GO:0043021" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|translational elongation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|protein kinase activator activity|activation of protein kinase activity|ribonucleoprotein complex binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPLP2 13619.40485 13714.08504 13524.72465 0.986192269 -0.020059152 0.954059384 1 1503.398327 1546.505917 6181 ribosomal protein lateral stalk subunit P2 "GO:0000184,GO:0002182,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translational elongation|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPN1 6483.294737 6416.551632 6550.037841 1.020803419 0.029705066 0.927826306 1 142.2835832 151.5000719 6184 ribophorin I "GO:0003723,GO:0004579,GO:0005515,GO:0005783,GO:0005789,GO:0005791,GO:0005829,GO:0006464,GO:0006487,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0042470" RNA binding|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|cytosol|cellular protein modification process|protein N-linked glycosylation|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|melanosome "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum RPN2 16452.74201 17567.87286 15337.61117 0.873048849 -0.195865717 0.580457467 1 357.0428509 325.1433045 6185 ribophorin II "GO:0000421,GO:0004579,GO:0005515,GO:0005783,GO:0005789,GO:0005791,GO:0006464,GO:0006487,GO:0007568,GO:0008250,GO:0016020,GO:0016021,GO:0016604,GO:0018279,GO:0042493,GO:0043022" autophagosome membrane|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|cellular protein modification process|protein N-linked glycosylation|aging|oligosaccharyltransferase complex|membrane|integral component of membrane|nuclear body|protein N-linked glycosylation via asparagine|response to drug|ribosome binding "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum RPP25 91.03971907 94.39090506 87.68853307 0.928993456 -0.106259661 0.894355286 1 2.02996448 1.967057355 54913 ribonuclease P and MRP subunit p25 "GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030681,GO:0033204,GO:0034451,GO:0090502" "ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|protein binding|nucleoplasm|nucleolus|rRNA processing|multimeric ribonuclease P complex|ribonuclease P RNA binding|centriolar satellite|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport RPP25L 334.9302724 366.3991046 303.4614403 0.828226479 -0.271902767 0.554201364 1 17.24611716 14.89897437 138716 ribonuclease P/MRP subunit p25 like "GO:0000172,GO:0001682,GO:0003723,GO:0005515" ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|protein binding "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport RPP30 1353.053335 1265.650093 1440.456577 1.138115965 0.186647565 0.579396226 1 11.10161279 13.17918399 10556 ribonuclease P/MRP subunit p30 "GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005515,GO:0005634,GO:0005654,GO:0005655,GO:0006364,GO:0008033,GO:0030681,GO:0033204,GO:0090502" "ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|protein binding|nucleus|nucleoplasm|nucleolar ribonuclease P complex|rRNA processing|tRNA processing|multimeric ribonuclease P complex|ribonuclease P RNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport RPP38 275.3717558 302.4568786 248.286633 0.820899277 -0.284722878 0.560693356 1 9.255815043 7.925386861 10557 ribonuclease P/MRP subunit p38 "GO:0001650,GO:0001682,GO:0004526,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030681,GO:0033204,GO:0090502" "fibrillar center|tRNA 5'-leader removal|ribonuclease P activity|protein binding|nucleoplasm|nucleolus|rRNA processing|multimeric ribonuclease P complex|ribonuclease P RNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport RPP40 103.2488822 120.7797602 85.71800424 0.709705037 -0.494708549 0.464168882 1 1.961856565 1.452315825 10799 ribonuclease P/MRP subunit p40 "GO:0000171,GO:0000172,GO:0000447,GO:0001682,GO:0004526,GO:0005634,GO:0005654,GO:0005655,GO:0030681,GO:0033204,GO:1905267" "ribonuclease MRP activity|ribonuclease MRP complex|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 5'-leader removal|ribonuclease P activity|nucleus|nucleoplasm|nucleolar ribonuclease P complex|multimeric ribonuclease P complex|ribonuclease P RNA binding|endonucleolytic cleavage involved in tRNA processing" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport RPRD1A 1625.0118 1503.149789 1746.873811 1.162142205 0.216786614 0.509634266 1 12.4090031 15.04222555 55197 regulation of nuclear pre-mRNA domain containing 1A "GO:0000993,GO:0005515,GO:0005654,GO:0016591,GO:0031124,GO:0042795,GO:0070940" "RNA polymerase II complex binding|protein binding|nucleoplasm|RNA polymerase II, holoenzyme|mRNA 3'-end processing|snRNA transcription by RNA polymerase II|dephosphorylation of RNA polymerase II C-terminal domain" RPRD1B 1704.315937 1805.606668 1603.025206 0.887804212 -0.171686541 0.599930931 1 14.60124667 13.52144385 58490 regulation of nuclear pre-mRNA domain containing 1B "GO:0000993,GO:0005515,GO:0005634,GO:0005654,GO:0008284,GO:0010564,GO:0016591,GO:0031124,GO:0042795,GO:0042802,GO:0045944,GO:0070940" "RNA polymerase II complex binding|protein binding|nucleus|nucleoplasm|positive regulation of cell population proliferation|regulation of cell cycle process|RNA polymerase II, holoenzyme|mRNA 3'-end processing|snRNA transcription by RNA polymerase II|identical protein binding|positive regulation of transcription by RNA polymerase II|dephosphorylation of RNA polymerase II C-terminal domain" RPRD2 1309.034878 1388.459765 1229.609992 0.885592815 -0.175284577 0.604535454 1 9.117151419 8.421882576 23248 regulation of nuclear pre-mRNA domain containing 2 "GO:0000993,GO:0005654,GO:0016591,GO:0031124,GO:0042795" "RNA polymerase II complex binding|nucleoplasm|RNA polymerase II, holoenzyme|mRNA 3'-end processing|snRNA transcription by RNA polymerase II" RPRM 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.108218819 0.03652608 56475 "reprimo, TP53 dependent G2 arrest mediator homolog" "GO:0005515,GO:0005737,GO:0007050,GO:0007346,GO:0016021" protein binding|cytoplasm|cell cycle arrest|regulation of mitotic cell cycle|integral component of membrane hsa04115 p53 signaling pathway RPS10 62.06621504 66.98709391 57.14533616 0.853079792 -0.229247405 0.787888806 1 4.117305814 3.663689921 6204 ribosomal protein S10 "GO:0000028,GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS11 17265.16552 17404.46495 17125.86609 0.983992679 -0.023280513 0.948083562 1 1538.350349 1578.930636 6205 ribosomal protein S11 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS12 11589.52409 11475.09218 11703.956 1.0199444 0.028490509 0.933643436 1 1155.413394 1229.220587 6206 ribosomal protein S12 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0043231" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|Golgi apparatus|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|intracellular membrane-bounded organelle" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS13 7743.622615 7573.601436 7913.643794 1.04489837 0.063362628 0.847924245 1 727.8485667 793.2882332 6207 ribosomal protein S13 "GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022627,GO:0033119,GO:0048027,GO:0070062,GO:0070181" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic small ribosomal subunit|negative regulation of RNA splicing|mRNA 5'-UTR binding|extracellular exosome|small ribosomal subunit rRNA binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS14 15706.81544 16181.443 15232.18788 0.941336806 -0.087217089 0.804556936 1 346.8188758 340.5365218 6208 ribosomal protein S14 "GO:0000028,GO:0000122,GO:0000184,GO:0000462,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006417,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022627,GO:0030218,GO:0030490,GO:0045182,GO:0048027,GO:0070062,GO:0070181" "ribosomal small subunit assembly|negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytosol|focal adhesion|rRNA processing|translation|translational initiation|regulation of translation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic small ribosomal subunit|erythrocyte differentiation|maturation of SSU-rRNA|translation regulator activity|mRNA 5'-UTR binding|extracellular exosome|small ribosomal subunit rRNA binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS15 8134.522439 8263.771494 8005.273384 0.968719112 -0.04584969 0.890128949 1 835.3909648 844.1187976 6209 ribosomal protein S15 "GO:0000028,GO:0000056,GO:0000184,GO:0001649,GO:0003677,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0042274" "ribosomal small subunit assembly|ribosomal small subunit export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|osteoblast differentiation|DNA binding|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|ribosomal small subunit biogenesis" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS15A 8795.638576 8769.219567 8822.057586 1.006025396 0.008666725 0.979605131 1 201.6023764 211.553649 6210 ribosomal protein S15a "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0008284,GO:0009615,GO:0016020,GO:0019083,GO:0022627,GO:0045787,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytoplasm|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|positive regulation of cell population proliferation|response to virus|membrane|viral transcription|cytosolic small ribosomal subunit|positive regulation of cell cycle|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS16 11125.72014 10717.93503 11533.50526 1.076093971 0.105804068 0.755531519 1 747.6936618 839.247057 6217 ribosomal protein S16 "GO:0000184,GO:0000462,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0016020,GO:0019083,GO:0022627,GO:0042274,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|membrane|viral transcription|cytosolic small ribosomal subunit|ribosomal small subunit biogenesis|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS17 30631.44797 30922.66349 30340.23244 0.981164913 -0.027432451 0.944073497 1 3209.270117 3284.461771 6218 ribosomal protein S17 "GO:0000184,GO:0003723,GO:0003735,GO:0005654,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0034101,GO:0042274" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleoplasm|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|erythrocyte homeostasis|ribosomal small subunit biogenesis" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS18 21505.82697 21889.55537 21122.09856 0.964939589 -0.051489471 0.888699259 1 2019.360215 2032.496704 6222 ribosomal protein S18 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0015935,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|small ribosomal subunit|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS19 10531.47629 10473.33064 10589.62195 1.011103565 0.015930777 0.962694134 1 251.1540005 264.8815272 6223 ribosomal protein S19 "GO:0000028,GO:0000184,GO:0000462,GO:0002548,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0007000,GO:0009991,GO:0014069,GO:0016020,GO:0017134,GO:0019083,GO:0019901,GO:0022627,GO:0030218,GO:0030490,GO:0031640,GO:0042274,GO:0042802,GO:0050829,GO:0051272,GO:0060265,GO:0060266,GO:0061844,GO:0070062" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|monocyte chemotaxis|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|nucleolus organization|response to extracellular stimulus|postsynaptic density|membrane|fibroblast growth factor binding|viral transcription|protein kinase binding|cytosolic small ribosomal subunit|erythrocyte differentiation|maturation of SSU-rRNA|killing of cells of other organism|ribosomal small subunit biogenesis|identical protein binding|defense response to Gram-negative bacterium|positive regulation of cellular component movement|positive regulation of respiratory burst involved in inflammatory response|negative regulation of respiratory burst involved in inflammatory response|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS19BP1 922.111 1003.791453 840.4305473 0.83725613 -0.256259061 0.474130105 1 61.99816575 54.1443453 91582 ribosomal protein S19 binding protein 1 "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0019899" RNA binding|protein binding|nucleoplasm|nucleolus|cytosol|enzyme binding RPS2 37108.57231 38870.78368 35346.36094 0.909329774 -0.137124503 0.734608684 1 2083.24663 1975.959456 6187 ribosomal protein S2 "GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0017134,GO:0019083,GO:0019899,GO:0022627,GO:0045296,GO:0051443,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|fibroblast growth factor binding|viral transcription|enzyme binding|cytosolic small ribosomal subunit|cadherin binding|positive regulation of ubiquitin-protein transferase activity|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS20 34252.10394 33637.6707 34866.53717 1.036532448 0.05176528 0.896716445 1 884.0837336 955.8554745 6224 ribosomal protein S20 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0016020,GO:0019083,GO:0022627,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|membrane|viral transcription|cytosolic small ribosomal subunit|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS21 10236.30869 10366.76026 10105.85712 0.974832722 -0.036773417 0.913391999 1 442.6980063 450.1462063 6227 ribosomal protein S21 "GO:0000184,GO:0000447,GO:0000461,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005791,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0019083,GO:0022627,GO:0042788,GO:0047485" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|rough endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|viral transcription|cytosolic small ribosomal subunit|polysomal ribosome|protein N-terminus binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS23 15285.22817 15245.6536 15324.80273 1.005191587 0.007470501 0.983230534 1 237.4349851 248.9484838 6228 ribosomal protein S23 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005783,GO:0005791,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0034063,GO:0042788,GO:1990145" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|endoplasmic reticulum|rough endoplasmic reticulum|cytosol|ribosome|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|stress granule assembly|polysomal ribosome|maintenance of translational fidelity" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS24 22364.39262 22657.87704 22070.9082 0.97409427 -0.037866696 0.918547002 1 405.3484775 411.8560638 6229 ribosomal protein S24 "GO:0000184,GO:0003723,GO:0003735,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0016020,GO:0019083,GO:0022627,GO:0031369,GO:0034101,GO:0042274" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|membrane|viral transcription|cytosolic small ribosomal subunit|translation initiation factor binding|erythrocyte homeostasis|ribosomal small subunit biogenesis" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS25 9172.541064 9209.710457 9135.37167 0.991928217 -0.011692375 0.972425476 1 965.7129291 999.1811219 6230 ribosomal protein S25 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0015935,GO:0019083,GO:0022627,GO:0042274,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|ribosome|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|small ribosomal subunit|viral transcription|cytosolic small ribosomal subunit|ribosomal small subunit biogenesis|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS26 2930.912489 3249.889011 2611.935968 0.803700052 -0.315270919 0.321935094 1 144.3819416 121.0382969 6231 ribosomal protein S26 "GO:0000184,GO:0002181,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0016020,GO:0019083,GO:0022627,GO:0033119,GO:0042788,GO:0045296,GO:0070062,GO:0098556" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|membrane|viral transcription|cytosolic small ribosomal subunit|negative regulation of RNA splicing|polysomal ribosome|cadherin binding|extracellular exosome|cytoplasmic side of rough endoplasmic reticulum membrane" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS27 13676.9473 13236.04078 14117.85382 1.066622116 0.093049147 0.788543228 1 1417.248989 1576.78569 6232 ribosomal protein S27 "GO:0000028,GO:0000184,GO:0003677,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005840,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008270,GO:0014069,GO:0019083,GO:0022627,GO:0098793,GO:0098978,GO:0098982" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|DNA binding|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|cytosol|ribosome|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|zinc ion binding|postsynaptic density|viral transcription|cytosolic small ribosomal subunit|presynapse|glutamatergic synapse|GABA-ergic synapse" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS27A 7306.691989 6969.702635 7643.681344 1.096701214 0.133170531 0.685307893 1 320.9007735 367.0920828 6233 ribosomal protein S27a "GO:0000122,GO:0000184,GO:0000187,GO:0000209,GO:0000715,GO:0000717,GO:0002755,GO:0002756,GO:0003723,GO:0003735,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005741,GO:0005789,GO:0005829,GO:0005886,GO:0006283,GO:0006294,GO:0006296,GO:0006297,GO:0006412,GO:0006413,GO:0006614,GO:0006625,GO:0007179,GO:0007249,GO:0007254,GO:0010008,GO:0015935,GO:0016020,GO:0016055,GO:0016197,GO:0016567,GO:0016579,GO:0019058,GO:0019068,GO:0019083,GO:0019221,GO:0019941,GO:0019985,GO:0022627,GO:0030512,GO:0030666,GO:0031145,GO:0031386,GO:0031625,GO:0031982,GO:0033683,GO:0035666,GO:0036297,GO:0042276,GO:0042769,GO:0043065,GO:0043066,GO:0043488,GO:0043657,GO:0044267,GO:0045944,GO:0046872,GO:0051092,GO:0051403,GO:0055085,GO:0061024,GO:0061418,GO:0070062,GO:0070423,GO:0070498,GO:0070911,GO:0070987,GO:0075733" "negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|activation of MAPK activity|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|RNA binding|structural constituent of ribosome|protein binding|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|protein targeting to peroxisome|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|small ribosomal subunit|membrane|Wnt signaling pathway|endosomal transport|protein ubiquitination|protein deubiquitination|viral life cycle|virion assembly|viral transcription|cytokine-mediated signaling pathway|modification-dependent protein catabolic process|translesion synthesis|cytosolic small ribosomal subunit|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|anaphase-promoting complex-dependent catabolic process|protein tag|ubiquitin protein ligase binding|vesicle|nucleotide-excision repair, DNA incision|TRIF-dependent toll-like receptor signaling pathway|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of mRNA stability|host cell|cellular protein metabolic process|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|transmembrane transport|membrane organization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|error-free translesion synthesis|intracellular transport of virus" "hsa03010,hsa04120,hsa04137,hsa05012,hsa05022,hsa05131,hsa05167,hsa05171" Ribosome|Ubiquitin mediated proteolysis|Mitophagy - animal|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection|Coronavirus disease - COVID-19 RPS27L 394.0312917 365.3841486 422.6784347 1.156805615 0.21014646 0.632309651 1 3.028710005 3.654550856 51065 ribosomal protein S27 like "GO:0000028,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0006412,GO:0006919,GO:0006978,GO:0008494,GO:0008656,GO:0022627,GO:0031571,GO:0042771,GO:0045727,GO:0046872" "ribosomal small subunit assembly|RNA binding|structural constituent of ribosome|protein binding|nucleus|translation|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|translation activator activity|cysteine-type endopeptidase activator activity involved in apoptotic process|cytosolic small ribosomal subunit|mitotic G1 DNA damage checkpoint|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of translation|metal ion binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS28 4076.583994 4314.577822 3838.590167 0.889679205 -0.168642863 0.597082489 1 164.2993577 152.4702931 6234 ribosomal protein S28 "GO:0000028,GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0019083,GO:0022627,GO:0030490,GO:0042254,GO:0042274,GO:0042788,GO:0070062,GO:0098556" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|viral transcription|cytosolic small ribosomal subunit|maturation of SSU-rRNA|ribosome biogenesis|ribosomal small subunit biogenesis|polysomal ribosome|extracellular exosome|cytoplasmic side of rough endoplasmic reticulum membrane" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS29 4807.157067 5055.495678 4558.818455 0.90175499 -0.149192593 0.641829861 1 34.26699965 32.23150348 6235 ribosomal protein S29 "GO:0000184,GO:0002181,GO:0003735,GO:0005654,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0008270,GO:0015935,GO:0019083,GO:0022627,GO:0042788,GO:0070062,GO:0098556" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|structural constituent of ribosome|nucleoplasm|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|zinc ion binding|small ribosomal subunit|viral transcription|cytosolic small ribosomal subunit|polysomal ribosome|extracellular exosome|cytoplasmic side of rough endoplasmic reticulum membrane" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS3 35163.70413 33922.87333 36404.53493 1.073155996 0.101859805 0.799267914 1 633.0412165 708.6157053 6188 ribosomal protein S3 "GO:0000184,GO:0000977,GO:0003677,GO:0003684,GO:0003723,GO:0003729,GO:0003735,GO:0003906,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005743,GO:0005759,GO:0005783,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0005925,GO:0006281,GO:0006412,GO:0006413,GO:0006614,GO:0006915,GO:0006974,GO:0007059,GO:0008017,GO:0008134,GO:0010628,GO:0014069,GO:0015631,GO:0016020,GO:0017148,GO:0019083,GO:0019104,GO:0019899,GO:0019900,GO:0019901,GO:0022627,GO:0030544,GO:0031116,GO:0031334,GO:0031397,GO:0032079,GO:0032357,GO:0032358,GO:0032587,GO:0032743,GO:0034614,GO:0042104,GO:0042769,GO:0042981,GO:0043507,GO:0044390,GO:0044877,GO:0045738,GO:0045739,GO:0050862,GO:0051018,GO:0051092,GO:0051225,GO:0051301,GO:0051536,GO:0051879,GO:0061481,GO:0070062,GO:0070181,GO:0070301,GO:0071159,GO:0071356,GO:0072686,GO:0097100,GO:0140078,GO:1901224,GO:1902231,GO:1902546,GO:1905053,GO:1990904,GO:2001235,GO:2001272" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|damaged DNA binding|RNA binding|mRNA binding|structural constituent of ribosome|DNA-(apurinic or apyrimidinic site) endonuclease activity|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrial inner membrane|mitochondrial matrix|endoplasmic reticulum|cytosol|ribosome|polysome|plasma membrane|focal adhesion|DNA repair|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|apoptotic process|cellular response to DNA damage stimulus|chromosome segregation|microtubule binding|transcription factor binding|positive regulation of gene expression|postsynaptic density|tubulin binding|membrane|negative regulation of translation|viral transcription|DNA N-glycosylase activity|enzyme binding|kinase binding|protein kinase binding|cytosolic small ribosomal subunit|Hsp70 protein binding|positive regulation of microtubule polymerization|positive regulation of protein-containing complex assembly|negative regulation of protein ubiquitination|positive regulation of endodeoxyribonuclease activity|oxidized purine DNA binding|oxidized pyrimidine DNA binding|ruffle membrane|positive regulation of interleukin-2 production|cellular response to reactive oxygen species|positive regulation of activated T cell proliferation|DNA damage response, detection of DNA damage|regulation of apoptotic process|positive regulation of JUN kinase activity|ubiquitin-like protein conjugating enzyme binding|protein-containing complex binding|negative regulation of DNA repair|positive regulation of DNA repair|positive regulation of T cell receptor signaling pathway|protein kinase A binding|positive regulation of NF-kappaB transcription factor activity|spindle assembly|cell division|iron-sulfur cluster binding|Hsp90 protein binding|response to TNF agonist|extracellular exosome|small ribosomal subunit rRNA binding|cellular response to hydrogen peroxide|NF-kappaB complex|cellular response to tumor necrosis factor|mitotic spindle|supercoiled DNA binding|class I DNA-(apurinic or apyrimidinic site) endonuclease activity|positive regulation of NIK/NF-kappaB signaling|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of DNA N-glycosylase activity|positive regulation of base-excision repair|ribonucleoprotein complex|positive regulation of apoptotic signaling pathway|positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis" "hsa03010,hsa05130,hsa05132,hsa05171" Ribosome|Pathogenic Escherichia coli infection|Salmonella infection|Coronavirus disease - COVID-19 RPS3A 12667.05301 12663.60562 12670.5004 1.000544456 0.000785271 0.998441951 1 326.2293744 340.4672814 6189 ribosomal protein S3A "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022627,GO:0030154,GO:0043066,GO:0048027,GO:0070062,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic small ribosomal subunit|cell differentiation|negative regulation of apoptotic process|mRNA 5'-UTR binding|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS4X 33986.33121 33149.47688 34823.18554 1.050489746 0.071062079 0.858339147 1 1139.012252 1248.06195 6191 ribosomal protein S4 X-linked "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0005840,GO:0005844,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0007275,GO:0008284,GO:0015935,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0036464,GO:0045202,GO:0045471,GO:0045727,GO:0070062,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|ribosome|polysome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|multicellular organism development|positive regulation of cell population proliferation|small ribosomal subunit|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|cytoplasmic ribonucleoprotein granule|synapse|response to ethanol|positive regulation of translation|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS5 11322.03569 11341.11799 11302.95339 0.996634846 -0.004863078 0.988884226 1 775.15198 805.8215142 6193 ribosomal protein S5 "GO:0000028,GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006450,GO:0006614,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0070062,GO:1990904" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|ribosome|focal adhesion|translation|translational initiation|regulation of translational fidelity|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS6 19001.57702 18844.68746 19158.46658 1.0166508 0.023824226 0.947530818 1 697.1635793 739.3029297 6194 ribosomal protein S6 "GO:0000082,GO:0000184,GO:0001890,GO:0002309,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005783,GO:0005829,GO:0005844,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0006924,GO:0007369,GO:0008284,GO:0015935,GO:0016020,GO:0019083,GO:0019901,GO:0022605,GO:0022627,GO:0030425,GO:0031929,GO:0033077,GO:0036464,GO:0042274,GO:0042593,GO:0043065,GO:0043066,GO:0044297,GO:0048471,GO:0048821,GO:1990904" "G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|placenta development|T cell proliferation involved in immune response|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|endoplasmic reticulum|cytosol|polysome|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|activation-induced cell death of T cells|gastrulation|positive regulation of cell population proliferation|small ribosomal subunit|membrane|viral transcription|protein kinase binding|mammalian oogenesis stage|cytosolic small ribosomal subunit|dendrite|TOR signaling|T cell differentiation in thymus|cytoplasmic ribonucleoprotein granule|ribosomal small subunit biogenesis|glucose homeostasis|positive regulation of apoptotic process|negative regulation of apoptotic process|cell body|perinuclear region of cytoplasm|erythrocyte development|ribonucleoprotein complex" "hsa01521,hsa03010,hsa04066,hsa04150,hsa04151,hsa04371,hsa04714,hsa04910,hsa05171,hsa05205" EGFR tyrosine kinase inhibitor resistance|Ribosome|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Thermogenesis|Insulin signaling pathway|Coronavirus disease - COVID-19|Proteoglycans in cancer RPS6KA1 1162.537044 1106.302006 1218.772083 1.101663088 0.139683084 0.685837644 1 15.09436794 17.3452139 6195 ribosomal protein S6 kinase A1 "GO:0000287,GO:0004674,GO:0004711,GO:0004712,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0007049,GO:0007165,GO:0018105,GO:0030307,GO:0035556,GO:0043027,GO:0043066,GO:0043154,GO:0043555,GO:0043620,GO:0045597,GO:0045893,GO:0045944,GO:0072574,GO:0106310,GO:0106311,GO:2000491" "magnesium ion binding|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cytosol|apoptotic process|cell cycle|signal transduction|peptidyl-serine phosphorylation|positive regulation of cell growth|intracellular signal transduction|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of translation in response to stress|regulation of DNA-templated transcription in response to stress|positive regulation of cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|hepatocyte proliferation|protein serine kinase activity|protein threonine kinase activity|positive regulation of hepatic stellate cell activation" "hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931,hsa05135" MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance|Yersinia infection RPS6KA2 195.318403 218.2155332 172.4212729 0.790142069 -0.339816019 0.534714561 1 1.698455039 1.399829591 6196 ribosomal protein S6 kinase A2 "GO:0000287,GO:0004674,GO:0004711,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0008285,GO:0018105,GO:0035556,GO:0043065,GO:0045786,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|negative regulation of cell population proliferation|peptidyl-serine phosphorylation|intracellular signal transduction|positive regulation of apoptotic process|negative regulation of cell cycle|protein serine kinase activity|protein threonine kinase activity "hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931,hsa05135" MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance|Yersinia infection RPS6KA3 2822.551217 2846.951491 2798.150943 0.982858665 -0.024944122 0.938677064 1 17.64415683 18.08872307 6197 ribosomal protein S6 kinase A3 "GO:0000287,GO:0001501,GO:0002224,GO:0004672,GO:0004674,GO:0004711,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006915,GO:0007049,GO:0007165,GO:0007417,GO:0018105,GO:0019901,GO:0030307,GO:0032496,GO:0035556,GO:0043027,GO:0043066,GO:0043154,GO:0043555,GO:0043620,GO:0045597,GO:0045944,GO:0106310,GO:0106311" magnesium ion binding|skeletal system development|toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|cytosol|apoptotic process|cell cycle|signal transduction|central nervous system development|peptidyl-serine phosphorylation|protein kinase binding|positive regulation of cell growth|response to lipopolysaccharide|intracellular signal transduction|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of translation in response to stress|regulation of DNA-templated transcription in response to stress|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|protein serine kinase activity|protein threonine kinase activity "hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931,hsa05135" MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance|Yersinia infection RPS6KA4 1320.148176 1306.248331 1334.04802 1.021282086 0.030381404 0.93050387 1 21.14989444 22.53044906 8986 ribosomal protein S6 kinase A4 "GO:0000287,GO:0001818,GO:0004674,GO:0004711,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006468,GO:0006954,GO:0016572,GO:0018105,GO:0032793,GO:0033129,GO:0035066,GO:0035556,GO:0043987,GO:0043988,GO:0045944,GO:0051092,GO:0070498,GO:0106310,GO:0106311" "magnesium ion binding|negative regulation of cytokine production|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|protein phosphorylation|inflammatory response|histone phosphorylation|peptidyl-serine phosphorylation|positive regulation of CREB transcription factor activity|positive regulation of histone phosphorylation|positive regulation of histone acetylation|intracellular signal transduction|histone H3-S10 phosphorylation|histone H3-S28 phosphorylation|positive regulation of transcription by RNA polymerase II|positive regulation of NF-kappaB transcription factor activity|interleukin-1-mediated signaling pathway|protein serine kinase activity|protein threonine kinase activity" "hsa04010,hsa04668" MAPK signaling pathway|TNF signaling pathway RPS6KA5 235.6899958 149.1985274 322.1814642 2.159414506 1.110640199 0.030905544 0.785916967 0.27202747 0.612723739 9252 ribosomal protein S6 kinase A5 "GO:0000287,GO:0001818,GO:0002223,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006468,GO:0006954,GO:0007173,GO:0007411,GO:0016572,GO:0018105,GO:0032793,GO:0033129,GO:0035066,GO:0035556,GO:0043987,GO:0043988,GO:0043990,GO:0045892,GO:0045944,GO:0051092,GO:0070498,GO:0106310,GO:0106311" "magnesium ion binding|negative regulation of cytokine production|stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|protein phosphorylation|inflammatory response|epidermal growth factor receptor signaling pathway|axon guidance|histone phosphorylation|peptidyl-serine phosphorylation|positive regulation of CREB transcription factor activity|positive regulation of histone phosphorylation|positive regulation of histone acetylation|intracellular signal transduction|histone H3-S10 phosphorylation|histone H3-S28 phosphorylation|histone H2A-S1 phosphorylation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of NF-kappaB transcription factor activity|interleukin-1-mediated signaling pathway|protein serine kinase activity|protein threonine kinase activity" "hsa04010,hsa04261,hsa04668,hsa04713,hsa04722,hsa05131,hsa05200,hsa05206,hsa05219" MAPK signaling pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Circadian entrainment|Neurotrophin signaling pathway|Shigellosis|Pathways in cancer|MicroRNAs in cancer|Bladder cancer RPS6KA6 416.0567265 288.247495 543.8659579 1.886802027 0.915943056 0.033485601 0.820898508 1.578069262 3.105763092 27330 ribosomal protein S6 kinase A6 "GO:0000287,GO:0001650,GO:0004672,GO:0004674,GO:0004711,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006978,GO:0007165,GO:0007417,GO:0018105,GO:0045992,GO:0070373,GO:0106310,GO:0106311,GO:2000381" "magnesium ion binding|fibrillar center|protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|mitochondrion|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|signal transduction|central nervous system development|peptidyl-serine phosphorylation|negative regulation of embryonic development|negative regulation of ERK1 and ERK2 cascade|protein serine kinase activity|protein threonine kinase activity|negative regulation of mesoderm development" "hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931,hsa05135" MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance|Yersinia infection RPS6KB1 943.7355989 899.250988 988.2202098 1.09893703 0.136108721 0.703975646 1 7.681546665 8.805163214 6198 ribosomal protein S6 kinase B1 "GO:0000082,GO:0001662,GO:0003009,GO:0004672,GO:0004674,GO:0004711,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0007165,GO:0007281,GO:0007568,GO:0007584,GO:0007616,GO:0009408,GO:0009611,GO:0009612,GO:0009636,GO:0009749,GO:0009986,GO:0014732,GO:0014878,GO:0014911,GO:0016301,GO:0016477,GO:0018105,GO:0030165,GO:0031667,GO:0031929,GO:0032496,GO:0032869,GO:0033574,GO:0033762,GO:0034612,GO:0042277,GO:0042493,GO:0042802,GO:0043005,GO:0043066,GO:0043201,GO:0043491,GO:0044539,GO:0045202,GO:0045471,GO:0045727,GO:0045931,GO:0045948,GO:0046324,GO:0046627,GO:0048015,GO:0048471,GO:0048633,GO:0048661,GO:0051721,GO:0071346,GO:0071363,GO:0071549,GO:0106310,GO:0106311,GO:2001237" G1/S transition of mitotic cell cycle|behavioral fear response|skeletal muscle contraction|protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|signal transduction|germ cell development|aging|response to nutrient|long-term memory|response to heat|response to wounding|response to mechanical stimulus|response to toxic substance|response to glucose|cell surface|skeletal muscle atrophy|response to electrical stimulus involved in regulation of muscle adaptation|positive regulation of smooth muscle cell migration|kinase activity|cell migration|peptidyl-serine phosphorylation|PDZ domain binding|response to nutrient levels|TOR signaling|response to lipopolysaccharide|cellular response to insulin stimulus|response to testosterone|response to glucagon|response to tumor necrosis factor|peptide binding|response to drug|identical protein binding|neuron projection|negative regulation of apoptotic process|response to leucine|protein kinase B signaling|long-chain fatty acid import into cell|synapse|response to ethanol|positive regulation of translation|positive regulation of mitotic cell cycle|positive regulation of translational initiation|regulation of glucose import|negative regulation of insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|positive regulation of skeletal muscle tissue growth|positive regulation of smooth muscle cell proliferation|protein phosphatase 2A binding|cellular response to interferon-gamma|cellular response to growth factor stimulus|cellular response to dexamethasone stimulus|protein serine kinase activity|protein threonine kinase activity|negative regulation of extrinsic apoptotic signaling pathway "hsa01521,hsa01522,hsa04012,hsa04066,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04350,hsa04371,hsa04666,hsa04714,hsa04910,hsa04931,hsa05131,hsa05163,hsa05165,hsa05170,hsa05200,hsa05205,hsa05210,hsa05212,hsa05221,hsa05224,hsa05225,hsa05226,hsa05231,hsa05235" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|TGF-beta signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Thermogenesis|Insulin signaling pathway|Insulin resistance|Shigellosis|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Pancreatic cancer|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer RPS6KB2 1011.069589 989.5820692 1032.557109 1.043427464 0.061330312 0.864085688 1 26.39222789 28.72461694 6199 ribosomal protein S6 kinase B2 "GO:0004672,GO:0004674,GO:0004711,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006412,GO:0007165,GO:0018105,GO:0031929,GO:0042277,GO:0043491,GO:0045948,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|translation|signal transduction|peptidyl-serine phosphorylation|TOR signaling|peptide binding|protein kinase B signaling|positive regulation of translational initiation|protein serine kinase activity|protein threonine kinase activity "hsa01521,hsa01522,hsa04012,hsa04066,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04350,hsa04371,hsa04666,hsa04714,hsa04910,hsa04931,hsa05131,hsa05163,hsa05165,hsa05170,hsa05200,hsa05205,hsa05210,hsa05212,hsa05221,hsa05224,hsa05225,hsa05226,hsa05231,hsa05235" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|TGF-beta signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Thermogenesis|Insulin signaling pathway|Insulin resistance|Shigellosis|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Pancreatic cancer|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer RPS6KC1 986.6188494 968.2679938 1004.969705 1.037904497 0.0536737 0.881886294 1 10.14677386 10.98503145 26750 ribosomal protein S6 kinase C1 "GO:0004674,GO:0005515,GO:0005524,GO:0005764,GO:0005768,GO:0005769,GO:0006468,GO:0007165,GO:0016020,GO:0035091,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|lysosome|endosome|early endosome|protein phosphorylation|signal transduction|membrane|phosphatidylinositol binding|protein serine kinase activity|protein threonine kinase activity RPS6KL1 140.2678051 159.348087 121.1875232 0.760520728 -0.394940525 0.518050666 1 1.472704099 1.168267999 83694 ribosomal protein S6 kinase like 1 "GO:0005524,GO:0005840,GO:0006468,GO:0106310,GO:0106311" ATP binding|ribosome|protein phosphorylation|protein serine kinase activity|protein threonine kinase activity RPS7 7722.65296 7150.364797 8294.941123 1.160072438 0.214214894 0.516003362 1 494.7278033 598.6422387 6201 ribosomal protein S7 "GO:0000184,GO:0001843,GO:0003723,GO:0003730,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008266,GO:0010628,GO:0016020,GO:0019083,GO:0019901,GO:0022627,GO:0030154,GO:0032040,GO:0032991,GO:0042274,GO:0045202,GO:0048027,GO:0050821,GO:1902255,GO:1904667,GO:1990904,GO:1990948,GO:2000059" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|neural tube closure|RNA binding|mRNA 3'-UTR binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|centrosome|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|poly(U) RNA binding|positive regulation of gene expression|membrane|viral transcription|protein kinase binding|cytosolic small ribosomal subunit|cell differentiation|small-subunit processome|protein-containing complex|ribosomal small subunit biogenesis|synapse|mRNA 5'-UTR binding|protein stabilization|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of ubiquitin protein ligase activity|ribonucleoprotein complex|ubiquitin ligase inhibitor activity|negative regulation of ubiquitin-dependent protein catabolic process" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS8 20637.93322 19809.91059 21465.95584 1.083596806 0.115828046 0.751274641 1 1289.591371 1457.591289 6202 ribosomal protein S8 "GO:0000184,GO:0000462,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0070062,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS9 9875.146432 9486.793436 10263.49943 1.081872341 0.113530274 0.735633128 1 471.5138569 532.0916063 6203 ribosomal protein S9 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008284,GO:0015935,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0045182,GO:0045202,GO:0045903,GO:0070062,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|positive regulation of cell population proliferation|small ribosomal subunit|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|translation regulator activity|synapse|positive regulation of translational fidelity|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPSA 37895.77927 37454.9201 38336.63845 1.023540788 0.033568595 0.93415755 1 1663.999623 1776.537206 3921 ribosomal protein SA "GO:0000028,GO:0000184,GO:0001618,GO:0002181,GO:0003723,GO:0003735,GO:0005055,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006614,GO:0007155,GO:0016020,GO:0019083,GO:0022627,GO:0043022,GO:0043236,GO:0046718,GO:0070062" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|virus receptor activity|cytoplasmic translation|RNA binding|structural constituent of ribosome|laminin receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|cell adhesion|membrane|viral transcription|cytosolic small ribosomal subunit|ribosome binding|laminin binding|viral entry into host cell|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPSAP58 1223.748885 1215.91725 1231.580521 1.012881856 0.018465906 0.959393777 1 27.36974188 28.91647984 388524 ribosomal protein SA pseudogene 58 RPTOR 1175.976923 1418.908444 933.0454025 0.65757971 -0.604762311 0.078406675 1 10.50931662 7.208398878 57521 regulatory associated protein of MTOR complex 1 "GO:0001002,GO:0001003,GO:0001006,GO:0001156,GO:0001558,GO:0001938,GO:0005515,GO:0005654,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0007050,GO:0008361,GO:0009267,GO:0010494,GO:0010506,GO:0010800,GO:0016032,GO:0016241,GO:0019901,GO:0030291,GO:0030295,GO:0030307,GO:0030425,GO:0030674,GO:0031669,GO:0031929,GO:0031931,GO:0032008,GO:0032147,GO:0033138,GO:0038202,GO:0043025,GO:0044877,GO:0045945,GO:0071230,GO:0071233,GO:0071889,GO:0071901,GO:0071902,GO:1900034,GO:1900087" RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 3 promoter sequence-specific DNA binding|TFIIIC-class transcription factor complex binding|regulation of cell growth|positive regulation of endothelial cell proliferation|protein binding|nucleoplasm|cytoplasm|lysosome|lysosomal membrane|cytosol|cell cycle arrest|regulation of cell size|cellular response to starvation|cytoplasmic stress granule|regulation of autophagy|positive regulation of peptidyl-threonine phosphorylation|viral process|regulation of macroautophagy|protein kinase binding|protein serine/threonine kinase inhibitor activity|protein kinase activator activity|positive regulation of cell growth|dendrite|protein-macromolecule adaptor activity|cellular response to nutrient levels|TOR signaling|TORC1 complex|positive regulation of TOR signaling|activation of protein kinase activity|positive regulation of peptidyl-serine phosphorylation|TORC1 signaling|neuronal cell body|protein-containing complex binding|positive regulation of transcription by RNA polymerase III|cellular response to amino acid stimulus|cellular response to leucine|14-3-3 protein binding|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|regulation of cellular response to heat|positive regulation of G1/S transition of mitotic cell cycle "hsa04136,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04714,hsa04910,hsa05131,hsa05206" Autophagy - other|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Thermogenesis|Insulin signaling pathway|Shigellosis|MicroRNAs in cancer RPUSD1 723.8274012 717.5738696 730.0809327 1.017429652 0.024929046 0.950920001 1 14.17417514 15.04243401 113000 RNA pseudouridine synthase domain containing 1 "GO:0000455,GO:0003674,GO:0003723,GO:0005515,GO:0005575,GO:0008150,GO:0009982" enzyme-directed rRNA pseudouridine synthesis|molecular_function|RNA binding|protein binding|cellular_component|biological_process|pseudouridine synthase activity RPUSD2 266.4328687 263.8885518 268.9771857 1.019283269 0.027555047 0.963585884 1 6.125125667 6.51217149 27079 RNA pseudouridine synthase domain containing 2 "GO:0000455,GO:0003723,GO:0005575,GO:0008150,GO:0009982" enzyme-directed rRNA pseudouridine synthesis|RNA binding|cellular_component|biological_process|pseudouridine synthase activity RPUSD3 639.6224283 652.6166877 626.6281689 0.960177974 -0.058626253 0.882865473 1 21.65972014 21.69304464 285367 RNA pseudouridine synthase D3 "GO:0000455,GO:0003723,GO:0005515,GO:0005759,GO:0006397,GO:0009982,GO:0070131" enzyme-directed rRNA pseudouridine synthesis|RNA binding|protein binding|mitochondrial matrix|mRNA processing|pseudouridine synthase activity|positive regulation of mitochondrial translation RPUSD4 679.7525292 432.3712425 927.133816 2.144300371 1.100507011 0.004110476 0.236073713 8.734773881 19.53679041 84881 RNA pseudouridine synthase D4 "GO:0000455,GO:0003723,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0008033,GO:0009982,GO:0070131" enzyme-directed rRNA pseudouridine synthesis|RNA binding|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|tRNA processing|pseudouridine synthase activity|positive regulation of mitochondrial translation RRAD 58.07789844 97.43577296 18.72002391 0.192126807 -2.379869269 0.005149563 0.273986513 3.359277173 0.673208721 6236 "RRAD, Ras related glycolysis inhibitor and calcium channel regulator" "GO:0003924,GO:0005246,GO:0005515,GO:0005516,GO:0005525,GO:0005886,GO:0007264,GO:1901842" GTPase activity|calcium channel regulator activity|protein binding|calmodulin binding|GTP binding|plasma membrane|small GTPase mediated signal transduction|negative regulation of high voltage-gated calcium channel activity RRAGA 1420.1347 1709.185851 1131.08355 0.661767443 -0.595603778 0.074873531 1 54.13648136 37.36898933 10670 Ras related GTP binding A "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0006915,GO:0007050,GO:0008219,GO:0009267,GO:0010506,GO:0010507,GO:0016241,GO:0016567,GO:0019048,GO:0031625,GO:0032008,GO:0034198,GO:0034448,GO:0034613,GO:0042803,GO:0046982,GO:0051219,GO:0071230,GO:1904263,GO:1990130,GO:1990131" GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|lysosome|lysosomal membrane|cytosol|apoptotic process|cell cycle arrest|cell death|cellular response to starvation|regulation of autophagy|negative regulation of autophagy|regulation of macroautophagy|protein ubiquitination|modulation by virus of host process|ubiquitin protein ligase binding|positive regulation of TOR signaling|cellular response to amino acid starvation|EGO complex|cellular protein localization|protein homodimerization activity|protein heterodimerization activity|phosphoprotein binding|cellular response to amino acid stimulus|positive regulation of TORC1 signaling|GATOR1 complex|Gtr1-Gtr2 GTPase complex "hsa04140,hsa04150,hsa05131" Autophagy - animal|mTOR signaling pathway|Shigellosis RRAGB 309.6602937 322.7559979 296.5645894 0.918850746 -0.12209756 0.799726647 1 6.917669353 6.630109512 10325 Ras related GTP binding B "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0007050,GO:0009267,GO:0010506,GO:0016241,GO:0032006,GO:0032008,GO:0032561,GO:0034198,GO:0034448,GO:0034613,GO:0051020,GO:0071230,GO:1904263,GO:1990131,GO:1990253" GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|lysosome|lysosomal membrane|cytosol|cell cycle arrest|cellular response to starvation|regulation of autophagy|regulation of macroautophagy|regulation of TOR signaling|positive regulation of TOR signaling|guanyl ribonucleotide binding|cellular response to amino acid starvation|EGO complex|cellular protein localization|GTPase binding|cellular response to amino acid stimulus|positive regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex|cellular response to leucine starvation "hsa04140,hsa04150,hsa05131" Autophagy - animal|mTOR signaling pathway|Shigellosis RRAGC 1131.684808 1051.494383 1211.875232 1.152526587 0.204800031 0.553822646 1 19.86366321 23.87955478 64121 Ras related GTP binding C "GO:0000287,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005829,GO:0006351,GO:0006915,GO:0007050,GO:0007264,GO:0008380,GO:0009267,GO:0010506,GO:0016241,GO:0019003,GO:0032006,GO:0032008,GO:0034198,GO:0034448,GO:0034613,GO:0043200,GO:0043231,GO:0046982,GO:0051020,GO:0071230,GO:1903432,GO:1990131" "magnesium ion binding|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|lysosome|cytosol|transcription, DNA-templated|apoptotic process|cell cycle arrest|small GTPase mediated signal transduction|RNA splicing|cellular response to starvation|regulation of autophagy|regulation of macroautophagy|GDP binding|regulation of TOR signaling|positive regulation of TOR signaling|cellular response to amino acid starvation|EGO complex|cellular protein localization|response to amino acid|intracellular membrane-bounded organelle|protein heterodimerization activity|GTPase binding|cellular response to amino acid stimulus|regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex" "hsa04140,hsa04150,hsa05131" Autophagy - animal|mTOR signaling pathway|Shigellosis RRAGD 829.4449266 899.250988 759.6388652 0.844746211 -0.24341012 0.505404063 1 7.306897188 6.438358851 58528 Ras related GTP binding D "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005813,GO:0005829,GO:0007050,GO:0009267,GO:0010506,GO:0016241,GO:0019003,GO:0032008,GO:0034448,GO:0034613,GO:0043231,GO:0046982,GO:0051020,GO:0071230,GO:0071233,GO:1904263,GO:1990131,GO:1990253" GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|lysosome|centrosome|cytosol|cell cycle arrest|cellular response to starvation|regulation of autophagy|regulation of macroautophagy|GDP binding|positive regulation of TOR signaling|EGO complex|cellular protein localization|intracellular membrane-bounded organelle|protein heterodimerization activity|GTPase binding|cellular response to amino acid stimulus|cellular response to leucine|positive regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex|cellular response to leucine starvation "hsa04140,hsa04150,hsa05131" Autophagy - animal|mTOR signaling pathway|Shigellosis RRAS 1329.38274 1196.633087 1462.132394 1.221871943 0.289093092 0.39109727 1 61.46576509 78.33843909 6237 RAS related "GO:0002521,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0005925,GO:0007265,GO:0010595,GO:0019003,GO:0030336,GO:0044877,GO:0045766,GO:0051896,GO:0060325,GO:0070062,GO:0070372,GO:1904906,GO:2001214" leukocyte differentiation|GTPase activity|protein binding|GTP binding|plasma membrane|focal adhesion|Ras protein signal transduction|positive regulation of endothelial cell migration|GDP binding|negative regulation of cell migration|protein-containing complex binding|positive regulation of angiogenesis|regulation of protein kinase B signaling|face morphogenesis|extracellular exosome|regulation of ERK1 and ERK2 cascade|positive regulation of endothelial cell-matrix adhesion via fibronectin|positive regulation of vasculogenesis "hsa04010,hsa04014,hsa04015,hsa04024,hsa04072,hsa04137,hsa04140,hsa04218,hsa04360,hsa04371,hsa04625,hsa04810,hsa05132,hsa05205" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Cellular senescence|Axon guidance|Apelin signaling pathway|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Salmonella infection|Proteoglycans in cancer RRAS2 1452.405697 1389.474721 1515.336673 1.090582398 0.125098775 0.708249586 1 24.79633292 28.20732304 22800 RAS related 2 "GO:0000139,GO:0001649,GO:0003924,GO:0005515,GO:0005525,GO:0005783,GO:0005886,GO:0005925,GO:0007265,GO:0016020,GO:0019003,GO:0030335,GO:0070062,GO:1901214" Golgi membrane|osteoblast differentiation|GTPase activity|protein binding|GTP binding|endoplasmic reticulum|plasma membrane|focal adhesion|Ras protein signal transduction|membrane|GDP binding|positive regulation of cell migration|extracellular exosome|regulation of neuron death "hsa04010,hsa04014,hsa04024,hsa04072,hsa04137,hsa04140,hsa04218,hsa04371,hsa04625,hsa04810,hsa05205" MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Cellular senescence|Apelin signaling pathway|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Proteoglycans in cancer RRBP1 6895.049655 7286.368897 6503.730414 0.892588682 -0.163932581 0.616465695 1 73.08949888 68.04908499 6238 ribosome binding protein 1 "GO:0001649,GO:0003723,GO:0005783,GO:0005840,GO:0006412,GO:0015031,GO:0016020,GO:0030176,GO:0038023" osteoblast differentiation|RNA binding|endoplasmic reticulum|ribosome|translation|protein transport|membrane|integral component of endoplasmic reticulum membrane|signaling receptor activity hsa04141 Protein processing in endoplasmic reticulum RREB1 820.6517757 904.3257678 736.9777836 0.814947235 -0.295221443 0.419760767 1 5.294290818 4.500421738 6239 ras responsive element binding protein 1 "GO:0000122,GO:0000977,GO:0000978,GO:0001228,GO:0001650,GO:0005634,GO:0005737,GO:0006355,GO:0006357,GO:0006366,GO:0007265,GO:0007275,GO:0010634,GO:0016604,GO:0016607,GO:0033601,GO:0045893,GO:0045944,GO:0046872,GO:0070062,GO:0090336,GO:1900026,GO:1903691,GO:2000394" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|nucleus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|Ras protein signal transduction|multicellular organism development|positive regulation of epithelial cell migration|nuclear body|nuclear speck|positive regulation of mammary gland epithelial cell proliferation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|extracellular exosome|positive regulation of brown fat cell differentiation|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of wound healing, spreading of epidermal cells|positive regulation of lamellipodium morphogenesis" RRM1 4664.633196 4000.956427 5328.309965 1.331759058 0.413333094 0.19708714 1 57.37098769 79.69552133 6240 ribonucleotide reductase catalytic subunit M1 "GO:0000278,GO:0004748,GO:0005515,GO:0005524,GO:0005635,GO:0005829,GO:0005971,GO:0006206,GO:0006260,GO:0008584,GO:0009263,GO:0010212,GO:0015949,GO:0021846,GO:0042802,GO:0042995,GO:0043025,GO:0051290,GO:0055114,GO:0060041,GO:0061731,GO:0097718" "mitotic cell cycle|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|protein binding|ATP binding|nuclear envelope|cytosol|ribonucleoside-diphosphate reductase complex|pyrimidine nucleobase metabolic process|DNA replication|male gonad development|deoxyribonucleotide biosynthetic process|response to ionizing radiation|nucleobase-containing small molecule interconversion|cell proliferation in forebrain|identical protein binding|cell projection|neuronal cell body|protein heterotetramerization|oxidation-reduction process|retina development in camera-type eye|ribonucleoside-diphosphate reductase activity|disordered domain specific binding" "hsa00230,hsa00240,hsa00480,hsa00983" Purine metabolism|Pyrimidine metabolism|Glutathione metabolism|Drug metabolism - other enzymes RRM2 3984.204688 3252.933879 4715.475498 1.449606931 0.535661759 0.093389734 1 48.0459683 72.64791207 6241 ribonucleotide reductase regulatory subunit M2 "GO:0000083,GO:0004748,GO:0005515,GO:0005829,GO:0006260,GO:0009263,GO:0015949,GO:0046872,GO:0055114,GO:0070317" "regulation of transcription involved in G1/S transition of mitotic cell cycle|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|protein binding|cytosol|DNA replication|deoxyribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|metal ion binding|oxidation-reduction process|negative regulation of G0 to G1 transition" "hsa00230,hsa00240,hsa00480,hsa00983,hsa04115" Purine metabolism|Pyrimidine metabolism|Glutathione metabolism|Drug metabolism - other enzymes|p53 signaling pathway RRM2B 695.5516486 737.872989 653.2303082 0.885288278 -0.175780775 0.643960923 1 7.410403298 6.842936157 50484 ribonucleotide reductase regulatory TP53 inducible subunit M2B "GO:0004748,GO:0005515,GO:0005654,GO:0005829,GO:0006260,GO:0006281,GO:0009263,GO:0015949,GO:0042802,GO:0046872,GO:0055114" "ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|protein binding|nucleoplasm|cytosol|DNA replication|DNA repair|deoxyribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|identical protein binding|metal ion binding|oxidation-reduction process" "hsa00230,hsa00240,hsa00480,hsa00983,hsa04115" Purine metabolism|Pyrimidine metabolism|Glutathione metabolism|Drug metabolism - other enzymes|p53 signaling pathway RRN3 909.1150107 923.6099312 894.6200902 0.968612463 -0.046008529 0.900832712 1 12.58476855 12.71484925 54700 "RRN3 homolog, RNA polymerase I transcription factor" "GO:0001042,GO:0001164,GO:0001181,GO:0001188,GO:0005634,GO:0005654,GO:0005730,GO:0006361,GO:0010976" RNA polymerase I core binding|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I general transcription initiation factor activity|RNA polymerase I preinitiation complex assembly|nucleus|nucleoplasm|nucleolus|transcription initiation from RNA polymerase I promoter|positive regulation of neuron projection development RRNAD1 429.9313382 394.8178717 465.0448046 1.177871717 0.236182423 0.580649127 1 7.600202344 9.337681973 51093 ribosomal RNA adenine dimethylase domain containing 1 "GO:0000179,GO:0016021,GO:0031167" "rRNA (adenine-N6,N6-)-dimethyltransferase activity|integral component of membrane|rRNA methylation" RRP1 689.9787933 794.7105232 585.2470634 0.736427978 -0.441383658 0.244167285 1 12.70094176 9.756232326 8568 ribosomal RNA processing 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005694,GO:0005730,GO:0006364,GO:0030687,GO:0030688" "RNA binding|protein binding|nucleus|chromosome|nucleolus|rRNA processing|preribosome, large subunit precursor|preribosome, small subunit precursor" RRP12 2069.6313 2464.313091 1674.949508 0.679682105 -0.557067956 0.08362733 1 26.33096297 18.66760091 23223 ribosomal RNA processing 12 homolog "GO:0003723,GO:0005730,GO:0005829,GO:0005886,GO:0006364,GO:0016021,GO:0031965,GO:0043231" RNA binding|nucleolus|cytosol|plasma membrane|rRNA processing|integral component of membrane|nuclear membrane|intracellular membrane-bounded organelle RRP15 456.4213922 488.1938208 424.6489635 0.869836826 -0.201183306 0.633077035 1 2.990119093 2.712952601 51018 ribosomal RNA processing 15 homolog "GO:0000460,GO:0000470,GO:0030687" "maturation of 5.8S rRNA|maturation of LSU-rRNA|preribosome, large subunit precursor" RRP1B 1816.303784 2220.723659 1411.883909 0.635776497 -0.65340841 0.044732006 0.960851996 22.14884188 14.6882962 23076 ribosomal RNA processing 1B "GO:0001652,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006364,GO:0006397,GO:0006915,GO:0008380,GO:0010923,GO:0016032,GO:0030687,GO:0030688,GO:0034260,GO:0043065,GO:0043484,GO:0043923,GO:0045944,GO:0098586" "granular component|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|rRNA processing|mRNA processing|apoptotic process|RNA splicing|negative regulation of phosphatase activity|viral process|preribosome, large subunit precursor|preribosome, small subunit precursor|negative regulation of GTPase activity|positive regulation of apoptotic process|regulation of RNA splicing|positive regulation by host of viral transcription|positive regulation of transcription by RNA polymerase II|cellular response to virus" RRP36 909.1837964 995.671805 822.6957878 0.826272054 -0.27531122 0.442953377 1 42.62659713 36.73835097 88745 ribosomal RNA processing 36 "GO:0000462,GO:0000469,GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0030686,GO:0042274" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cleavage involved in rRNA processing|RNA binding|nucleoplasm|nucleolus|rRNA processing|90S preribosome|ribosomal small subunit biogenesis" RRP7A 1299.86514 1435.147739 1164.58254 0.811472233 -0.301386366 0.372751067 1 13.41302272 11.3531468 27341 ribosomal RNA processing 7 homolog A "GO:0000028,GO:0001825,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0006364,GO:0032545,GO:0034456" ribosomal small subunit assembly|blastocyst formation|RNA binding|protein binding|nucleoplasm|cytoplasm|rRNA processing|CURI complex|UTP-C complex hsa03008 Ribosome biogenesis in eukaryotes RRP8 352.5611115 359.2944128 345.8278102 0.96251931 -0.055112611 0.908765023 1 1.643811607 1.650355191 23378 ribosomal RNA processing 8 "GO:0000183,GO:0003723,GO:0005515,GO:0005654,GO:0005677,GO:0005730,GO:0005829,GO:0005886,GO:0006364,GO:0008757,GO:0032259,GO:0033553,GO:0035064,GO:0042149,GO:0046015,GO:0071158,GO:0072332" rDNA heterochromatin assembly|RNA binding|protein binding|nucleoplasm|chromatin silencing complex|nucleolus|cytosol|plasma membrane|rRNA processing|S-adenosylmethionine-dependent methyltransferase activity|methylation|rDNA heterochromatin|methylated histone binding|cellular response to glucose starvation|regulation of transcription by glucose|positive regulation of cell cycle arrest|intrinsic apoptotic signaling pathway by p53 class mediator RRP9 480.7506438 534.8817953 426.6194924 0.797595835 -0.326270218 0.430089226 1 17.56801296 14.6157616 9136 "ribosomal RNA processing 9, U3 small nucleolar RNA binding protein" "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030515,GO:0031428,GO:0032040,GO:0034511" RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|snoRNA binding|box C/D RNP complex|small-subunit processome|U3 snoRNA binding RRS1 867.0143809 1143.855376 590.1733855 0.515951053 -0.954693889 0.008692667 0.39115812 33.68153461 18.126598 23212 ribosome biogenesis regulator 1 homolog "GO:0000027,GO:0000055,GO:0000447,GO:0000794,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0007080,GO:0008097,GO:0030687,GO:0042273,GO:1901796,GO:1902570" "ribosomal large subunit assembly|ribosomal large subunit export from nucleus|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|condensed nuclear chromosome|RNA binding|protein binding|nucleoplasm|nucleolus|mitotic metaphase plate congression|5S rRNA binding|preribosome, large subunit precursor|ribosomal large subunit biogenesis|regulation of signal transduction by p53 class mediator|protein localization to nucleolus" RSAD1 849.6252797 931.729579 767.5209805 0.82375938 -0.279705107 0.441598417 1 19.12801631 16.43562547 55316 radical S-adenosyl methionine domain containing 1 "GO:0004109,GO:0005575,GO:0005737,GO:0005739,GO:0006779,GO:0008150,GO:0020037,GO:0046872,GO:0051539,GO:0055114" "coproporphyrinogen oxidase activity|cellular_component|cytoplasm|mitochondrion|porphyrin-containing compound biosynthetic process|biological_process|heme binding|metal ion binding|4 iron, 4 sulfur cluster binding|oxidation-reduction process" RSBN1 573.9984242 645.5119959 502.4848524 0.778428373 -0.3613638 0.360773986 1 2.020700004 1.640727393 54665 round spermatid basic protein 1 "GO:0005634,GO:0006325,GO:0046872,GO:0051213,GO:0055114" nucleus|chromatin organization|metal ion binding|dioxygenase activity|oxidation-reduction process RSBN1L 509.536596 482.104085 536.969107 1.113803271 0.155494435 0.705168685 1 3.811562776 4.428202735 222194 round spermatid basic protein 1 like "GO:0005634,GO:0046872,GO:0051213,GO:0055114" nucleus|metal ion binding|dioxygenase activity|oxidation-reduction process RSF1 1635.274683 1598.55565 1671.993715 1.045940262 0.064800455 0.845043223 1 7.150154934 7.800784184 51773 remodeling and spacing factor 1 "GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0006334,GO:0006338,GO:0006352,GO:0016584,GO:0016887,GO:0031213,GO:0034080,GO:0042393,GO:0043392,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0050434" "transcription coregulator activity|protein binding|nucleus|nucleoplasm|nucleosome assembly|chromatin remodeling|DNA-templated transcription, initiation|nucleosome positioning|ATPase activity|RSF complex|CENP-A containing nucleosome assembly|histone binding|negative regulation of DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of viral transcription" RSKR 115.6092248 123.8246281 107.3938214 0.867305826 -0.205387294 0.760132721 1 1.662587643 1.504086252 124923 ribosomal protein S6 kinase related "GO:0005515,GO:0005524,GO:0006468,GO:0106310,GO:0106311" protein binding|ATP binding|protein phosphorylation|protein serine kinase activity|protein threonine kinase activity RSL1D1 1932.114169 2257.262074 1606.966263 0.711909477 -0.490234287 0.12950606 1 21.01513987 15.60533116 26156 ribosomal L1 domain containing 1 "GO:0000470,GO:0001649,GO:0003723,GO:0003730,GO:0005694,GO:0005730,GO:0016020,GO:0030686,GO:0032880,GO:0042981,GO:0045296,GO:0048027,GO:2000772" maturation of LSU-rRNA|osteoblast differentiation|RNA binding|mRNA 3'-UTR binding|chromosome|nucleolus|membrane|90S preribosome|regulation of protein localization|regulation of apoptotic process|cadherin binding|mRNA 5'-UTR binding|regulation of cellular senescence RSL24D1 1114.269974 972.3278177 1256.212131 1.291963583 0.369565405 0.285733658 1 26.06933499 35.13145645 51187 ribosomal L24 domain containing 1 "GO:0000027,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0006412,GO:0022625,GO:1902626" ribosomal large subunit assembly|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|translation|cytosolic large ribosomal subunit|assembly of large subunit precursor of preribosome "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RSPH3 270.4360311 234.4548287 306.4172335 1.306935051 0.386187447 0.430956169 1 1.931410209 2.632961193 83861 radial spoke head 3 "GO:0005515,GO:0005737,GO:0005856,GO:0005929" protein binding|cytoplasm|cytoskeleton|cilium RSPH4A 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.032092361 0.008123874 345895 radial spoke head component 4A "GO:0001534,GO:0003341,GO:0003674,GO:0005654,GO:0005730,GO:0005930,GO:0031514,GO:0035082,GO:0060294,GO:0062177" radial spoke|cilium movement|molecular_function|nucleoplasm|nucleolus|axoneme|motile cilium|axoneme assembly|cilium movement involved in cell motility|radial spoke assembly RSPO3 10.95667479 8.119647747 13.79370183 1.698805448 0.764520641 0.605113886 1 0.137031494 0.242817491 84870 R-spondin 3 "GO:0001974,GO:0002040,GO:0005102,GO:0005109,GO:0005576,GO:0008201,GO:0016055,GO:0030111,GO:0030177,GO:0060670,GO:0090263,GO:2000052,GO:2000096" "blood vessel remodeling|sprouting angiogenesis|signaling receptor binding|frizzled binding|extracellular region|heparin binding|Wnt signaling pathway|regulation of Wnt signaling pathway|positive regulation of Wnt signaling pathway|branching involved in labyrinthine layer morphogenesis|positive regulation of canonical Wnt signaling pathway|positive regulation of non-canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway RSPRY1 664.4712821 734.8281211 594.1144432 0.808508039 -0.306665976 0.422736599 1 8.89919943 7.505008899 89970 ring finger and SPRY domain containing 1 "GO:0004842,GO:0005576,GO:0005737,GO:0016567,GO:0046872,GO:0051603" ubiquitin-protein transferase activity|extracellular region|cytoplasm|protein ubiquitination|metal ion binding|proteolysis involved in cellular protein catabolic process RSRC1 380.4778438 348.1298972 412.8257905 1.185838372 0.245907386 0.578602921 1 6.7244665 8.317623605 51319 arginine and serine rich coiled-coil 1 "GO:0000380,GO:0000398,GO:0005515,GO:0005634,GO:0005737,GO:0006468,GO:0006913,GO:0008380,GO:0016607,GO:0046677" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|protein binding|nucleus|cytoplasm|protein phosphorylation|nucleocytoplasmic transport|RNA splicing|nuclear speck|response to antibiotic" RSRC2 1043.09192 1158.06476 928.1190804 0.801439706 -0.319334108 0.361600395 1 15.45097331 12.91643393 65117 arginine and serine rich coiled-coil 2 "GO:0003723,GO:0005515" RNA binding|protein binding RSRP1 398.6282851 376.5486643 420.7079059 1.117273664 0.159982602 0.716162577 1 6.772322962 7.892473865 57035 arginine and serine rich protein 1 GO:0005515 protein binding RSU1 1894.883445 2069.49522 1720.271671 0.831251822 -0.266642498 0.410095098 1 27.89795904 24.1891703 6251 Ras suppressor protein 1 "GO:0005515,GO:0005829,GO:0005925,GO:0007165,GO:0010810,GO:0010811,GO:0043547,GO:0070062" protein binding|cytosol|focal adhesion|signal transduction|regulation of cell-substrate adhesion|positive regulation of cell-substrate adhesion|positive regulation of GTPase activity|extracellular exosome RTBDN 57.1102014 64.95718198 49.26322083 0.758395289 -0.398978091 0.634436665 1 1.998695086 1.581095495 83546 retbindin "GO:0031362,GO:0032217,GO:0032218,GO:0033165,GO:0038023,GO:1902444" anchored component of external side of plasma membrane|riboflavin transmembrane transporter activity|riboflavin transport|interphotoreceptor matrix|signaling receptor activity|riboflavin binding RTCA 771.6990784 757.1571524 786.2410044 1.038411909 0.054378835 0.886477316 1 14.35154891 15.54477232 8634 RNA 3'-terminal phosphate cyclase "GO:0003723,GO:0003963,GO:0005524,GO:0005634,GO:0005654,GO:0006396" RNA binding|RNA-3'-phosphate cyclase activity|ATP binding|nucleus|nucleoplasm|RNA processing RTCB 2506.976615 2557.68904 2456.26419 0.960345121 -0.058375132 0.855864759 1 64.15944869 64.26934701 51493 "RNA 2',3'-cyclic phosphate and 5'-OH ligase" "GO:0000971,GO:0003723,GO:0003972,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006388,GO:0017166,GO:0043231,GO:0046872,GO:0072669" "tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate|RNA binding|RNA ligase (ATP) activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|tRNA splicing, via endonucleolytic cleavage and ligation|vinculin binding|intracellular membrane-bounded organelle|metal ion binding|tRNA-splicing ligase complex" RTEL1 1583.491639 1561.002279 1605.980999 1.028814 0.04098218 0.902821221 1 15.75199414 16.90395534 51750 regulator of telomere elongation helicase 1 "GO:0000723,GO:0000732,GO:0000781,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0010569,GO:0031297,GO:0032206,GO:0032508,GO:0043247,GO:0045910,GO:0046872,GO:0051539,GO:0070182,GO:0090657,GO:1902990,GO:1904355,GO:1904358,GO:1904430,GO:1904506,GO:1904535" "telomere maintenance|strand displacement|chromosome, telomeric region|DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|regulation of double-strand break repair via homologous recombination|replication fork processing|positive regulation of telomere maintenance|DNA duplex unwinding|telomere maintenance in response to DNA damage|negative regulation of DNA recombination|metal ion binding|4 iron, 4 sulfur cluster binding|DNA polymerase binding|telomeric loop disassembly|mitotic telomere maintenance via semi-conservative replication|positive regulation of telomere capping|positive regulation of telomere maintenance via telomere lengthening|negative regulation of t-circle formation|negative regulation of telomere maintenance in response to DNA damage|positive regulation of telomeric loop disassembly" RTF1 1670.099152 1453.416947 1886.781358 1.298169367 0.376478618 0.250405382 1 14.66051404 19.85164429 23168 "RTF1 homolog, Paf1/RNA polymerase II complex component" "GO:0000122,GO:0001711,GO:0001832,GO:0003697,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006366,GO:0006368,GO:0016055,GO:0016567,GO:0016593,GO:0019827,GO:0051571,GO:0080182,GO:1990269" negative regulation of transcription by RNA polymerase II|endodermal cell fate commitment|blastocyst growth|single-stranded DNA binding|RNA binding|protein binding|nucleoplasm|nucleolus|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|stem cell population maintenance|positive regulation of histone H3-K4 methylation|histone H3-K4 trimethylation|RNA polymerase II C-terminal domain phosphoserine binding RTF2 2522.856891 2599.302235 2446.411546 0.941180103 -0.087457273 0.7848003 1 68.92433948 67.66456282 51507 replication termination factor 2 "GO:0003677,GO:0005515,GO:0005634,GO:0005657,GO:0071171,GO:0072711,GO:0097752,GO:1902979" DNA binding|protein binding|nucleus|replication fork|site-specific DNA replication termination at RTS1 barrier|cellular response to hydroxyurea|regulation of DNA stability|mitotic DNA replication termination RTKN 321.1865511 302.4568786 339.9162237 1.123850201 0.16844975 0.720314517 1 4.647564896 5.448159581 6242 rhotekin "GO:0000281,GO:0000915,GO:0005095,GO:0005515,GO:0005525,GO:0005575,GO:0005826,GO:0005829,GO:0006915,GO:0007165,GO:0007266,GO:0031106,GO:0031267,GO:0034260,GO:0042981" mitotic cytokinesis|actomyosin contractile ring assembly|GTPase inhibitor activity|protein binding|GTP binding|cellular_component|actomyosin contractile ring|cytosol|apoptotic process|signal transduction|Rho protein signal transduction|septin ring organization|small GTPase binding|negative regulation of GTPase activity|regulation of apoptotic process RTKN2 35.39256851 28.41876711 42.36636991 1.490788455 0.576075551 0.551567845 1 0.145047899 0.225550291 219790 rhotekin 2 "GO:0005634,GO:0005737,GO:0005886,GO:0007165,GO:0008284,GO:0030097,GO:0051092,GO:1901224,GO:2001243" nucleus|cytoplasm|plasma membrane|signal transduction|positive regulation of cell population proliferation|hemopoiesis|positive regulation of NF-kappaB transcription factor activity|positive regulation of NIK/NF-kappaB signaling|negative regulation of intrinsic apoptotic signaling pathway RTL10 955.3388069 850.5331015 1060.144512 1.246447093 0.317821648 0.371259952 1 6.474748398 8.418072772 79680 retrotransposon Gag like 10 "GO:0005515,GO:0005739,GO:0051881,GO:0097345" protein binding|mitochondrion|regulation of mitochondrial membrane potential|mitochondrial outer membrane permeabilization RTL5 22.77984779 8.119647747 37.44004783 4.61104336 2.205093232 0.048321428 1 0.094470828 0.454373357 340526 retrotransposon Gag like 5 RTL6 1935.27904 2439.954148 1430.603933 0.586324105 -0.770229724 0.017558982 0.573480571 22.80403579 13.9465052 84247 retrotransposon Gag like 6 RTL8A 1455.010635 1298.128684 1611.892585 1.241704775 0.312322203 0.348193642 1 54.60601188 70.72529055 26071 retrotransposon Gag like 8A "GO:0005515,GO:0005730" protein binding|nucleolus RTL8B 308.2714717 328.8457338 287.6972096 0.874869825 -0.192859725 0.68485292 1 8.20437257 7.486946701 441518 retrotransposon Gag like 8B "GO:0005515,GO:0005730" protein binding|nucleolus RTL8C 2769.711648 2400.370865 3139.052431 1.307736432 0.387071802 0.224392747 1 101.9885204 139.1193193 8933 retrotransposon Gag like 8C RTN1 10.91213746 5.074779842 16.74949508 3.3005363 1.722700465 0.217821214 1 0.041969252 0.144487963 6252 reticulon 1 "GO:0000139,GO:0005515,GO:0005783,GO:0030176,GO:1902430" Golgi membrane|protein binding|endoplasmic reticulum|integral component of endoplasmic reticulum membrane|negative regulation of amyloid-beta formation RTN2 329.2198458 279.1128913 379.3268004 1.359044359 0.442592546 0.33603494 1 6.577981989 9.324858319 6253 reticulon 2 "GO:0005515,GO:0005783,GO:0005882,GO:0009986,GO:0014802,GO:0030018,GO:0030176,GO:0030315,GO:0046324,GO:0065002,GO:1902430" protein binding|endoplasmic reticulum|intermediate filament|cell surface|terminal cisterna|Z disc|integral component of endoplasmic reticulum membrane|T-tubule|regulation of glucose import|intracellular protein transmembrane transport|negative regulation of amyloid-beta formation RTN3 4672.254522 4454.641745 4889.867299 1.097701584 0.134485903 0.674723565 1 32.19807184 36.86634522 10313 reticulon 3 "GO:0000139,GO:0005515,GO:0005615,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006915,GO:0016021,GO:0016032,GO:0016192,GO:0045202,GO:0071786,GO:0071787,GO:1902430" Golgi membrane|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|apoptotic process|integral component of membrane|viral process|vesicle-mediated transport|synapse|endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network formation|negative regulation of amyloid-beta formation hsa05010 Alzheimer disease RTN4 5504.475855 5173.230571 5835.721139 1.128061288 0.173845452 0.590224686 1 37.5420373 44.17397308 57142 reticulon 4 "GO:0001825,GO:0003723,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005886,GO:0006915,GO:0007413,GO:0010634,GO:0014069,GO:0021801,GO:0030176,GO:0030308,GO:0030517,GO:0031625,GO:0033601,GO:0034165,GO:0042981,GO:0042995,GO:0043025,GO:0045296,GO:0050771,GO:0050821,GO:0051292,GO:0051897,GO:0060317,GO:0061462,GO:0071782,GO:0071786,GO:0071787,GO:0090156,GO:0098826,GO:1902430,GO:1905552,GO:1905580,GO:1990809,GO:2000172" blastocyst formation|RNA binding|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|apoptotic process|axonal fasciculation|positive regulation of epithelial cell migration|postsynaptic density|cerebral cortex radial glia guided migration|integral component of endoplasmic reticulum membrane|negative regulation of cell growth|negative regulation of axon extension|ubiquitin protein ligase binding|positive regulation of mammary gland epithelial cell proliferation|positive regulation of toll-like receptor 9 signaling pathway|regulation of apoptotic process|cell projection|neuronal cell body|cadherin binding|negative regulation of axonogenesis|protein stabilization|nuclear pore complex assembly|positive regulation of protein kinase B signaling|cardiac epithelial to mesenchymal transition|protein localization to lysosome|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network formation|cellular sphingolipid homeostasis|endoplasmic reticulum tubular network membrane|negative regulation of amyloid-beta formation|positive regulation of protein localization to endoplasmic reticulum|positive regulation of ERBB3 signaling pathway|endoplasmic reticulum tubular network membrane organization|regulation of branching morphogenesis of a nerve hsa05010 Alzheimer disease RTN4IP1 135.7005033 150.2134833 121.1875232 0.806768611 -0.309773142 0.618629846 1 2.075793454 1.746823639 84816 reticulon 4 interacting protein 1 "GO:0005515,GO:0005739,GO:0005741,GO:0007399,GO:0008270,GO:0016491,GO:0050773,GO:0055114" protein binding|mitochondrion|mitochondrial outer membrane|nervous system development|zinc ion binding|oxidoreductase activity|regulation of dendrite development|oxidation-reduction process RTN4R 95.32767278 50.74779842 139.9075471 2.756918556 1.463056648 0.036115396 0.858303341 1.322117779 3.801981608 65078 reticulon 4 receptor "GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0007166,GO:0008201,GO:0009986,GO:0010977,GO:0022038,GO:0023041,GO:0030517,GO:0031362,GO:0035025,GO:0035374,GO:0038023,GO:0038131,GO:0043005,GO:0043025,GO:0043198,GO:0043204,GO:0043547,GO:0044295,GO:0045121,GO:0048681,GO:0050771,GO:0070062,GO:1905573,GO:1905576" protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|heparin binding|cell surface|negative regulation of neuron projection development|corpus callosum development|neuronal signal transduction|negative regulation of axon extension|anchored component of external side of plasma membrane|positive regulation of Rho protein signal transduction|chondroitin sulfate binding|signaling receptor activity|neuregulin receptor activity|neuron projection|neuronal cell body|dendritic shaft|perikaryon|positive regulation of GTPase activity|axonal growth cone|membrane raft|negative regulation of axon regeneration|negative regulation of axonogenesis|extracellular exosome|ganglioside GM1 binding|ganglioside GT1b binding RTN4RL2 6.030352707 8.119647747 3.941057666 0.485372985 -1.042834281 0.589955466 1 0.184906256 0.093614503 349667 reticulon 4 receptor like 2 "GO:0005576,GO:0005615,GO:0005886,GO:0007166,GO:0009897,GO:0009986,GO:0010977,GO:0030424,GO:0030425,GO:0031012,GO:0031103,GO:0038023,GO:0043005,GO:0043204,GO:0045121,GO:0046658,GO:0070062" extracellular region|extracellular space|plasma membrane|cell surface receptor signaling pathway|external side of plasma membrane|cell surface|negative regulation of neuron projection development|axon|dendrite|extracellular matrix|axon regeneration|signaling receptor activity|neuron projection|perikaryon|membrane raft|anchored component of plasma membrane|extracellular exosome RTP4 6.030352707 8.119647747 3.941057666 0.485372985 -1.042834281 0.589955466 1 0.273971695 0.138706632 64108 receptor transporter protein 4 "GO:0001580,GO:0005515,GO:0005737,GO:0006612,GO:0016021,GO:0031849,GO:0051205,GO:0051607" detection of chemical stimulus involved in sensory perception of bitter taste|protein binding|cytoplasm|protein targeting to membrane|integral component of membrane|olfactory receptor binding|protein insertion into membrane|defense response to virus RTRAF 2320.490457 2404.430689 2236.550226 0.930178705 -0.104420182 0.744782556 1 17.37918254 16.86210027 51637 "RNA transcription, translation and transport factor" "GO:0000993,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006388,GO:0006469,GO:0016032,GO:0042802,GO:0045944,GO:0048471,GO:0050658,GO:0072669,GO:0072686" "RNA polymerase II complex binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|tRNA splicing, via endonucleolytic cleavage and ligation|negative regulation of protein kinase activity|viral process|identical protein binding|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|RNA transport|tRNA-splicing ligase complex|mitotic spindle" RTTN 917.43854 819.0694665 1015.807613 1.240197144 0.310569473 0.385816304 1 3.2050513 4.146117846 25914 rotatin "GO:0005737,GO:0005813,GO:0005814,GO:0007099,GO:0007368,GO:0010457,GO:0032053,GO:0036064" cytoplasm|centrosome|centriole|centriole replication|determination of left/right symmetry|centriole-centriole cohesion|ciliary basal body organization|ciliary basal body RUBCN 902.9146735 802.830171 1002.999176 1.249329201 0.32115368 0.371209104 1 4.139738948 5.394681089 9711 rubicon autophagy regulator "GO:0002376,GO:0005515,GO:0005654,GO:0005764,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0006897,GO:0006909,GO:0006914,GO:0010507,GO:0043231,GO:0043553,GO:0045806,GO:0071985,GO:1901097,GO:1901981" immune system process|protein binding|nucleoplasm|lysosome|early endosome|late endosome|Golgi apparatus|cytosol|endocytosis|phagocytosis|autophagy|negative regulation of autophagy|intracellular membrane-bounded organelle|negative regulation of phosphatidylinositol 3-kinase activity|negative regulation of endocytosis|multivesicular body sorting pathway|negative regulation of autophagosome maturation|phosphatidylinositol phosphate binding hsa04140 Autophagy - animal RUBCNL 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.009241988 0.014037126 80183 rubicon like autophagy enhancer "GO:0000421,GO:0005515,GO:0006629,GO:0010314,GO:0019216,GO:0031410,GO:0032266,GO:0043231,GO:0061909,GO:0061910,GO:0070273,GO:0070873,GO:0097352,GO:1901981" autophagosome membrane|protein binding|lipid metabolic process|phosphatidylinositol-5-phosphate binding|regulation of lipid metabolic process|cytoplasmic vesicle|phosphatidylinositol-3-phosphate binding|intracellular membrane-bounded organelle|autophagosome-lysosome fusion|autophagosome-endosome fusion|phosphatidylinositol-4-phosphate binding|regulation of glycogen metabolic process|autophagosome maturation|phosphatidylinositol phosphate binding RUFY1 804.2155258 723.6636055 884.7674461 1.222622555 0.289979087 0.430003595 1 10.447836 13.32400171 80230 RUN and FYVE domain containing 1 "GO:0005515,GO:0005737,GO:0005768,GO:0005829,GO:0006661,GO:0006897,GO:0007264,GO:0008289,GO:0015031,GO:0016607,GO:0017124,GO:0030100,GO:0031901,GO:0042169,GO:0043231,GO:0046872" protein binding|cytoplasm|endosome|cytosol|phosphatidylinositol biosynthetic process|endocytosis|small GTPase mediated signal transduction|lipid binding|protein transport|nuclear speck|SH3 domain binding|regulation of endocytosis|early endosome membrane|SH2 domain binding|intracellular membrane-bounded organelle|metal ion binding hsa04144 Endocytosis RUFY2 725.924861 625.2128765 826.6368455 1.322168619 0.402906178 0.28257479 1 4.49656725 6.201316082 55680 RUN and FYVE domain containing 2 "GO:0005634,GO:0005737,GO:0005768,GO:0008150,GO:0017124,GO:0030100,GO:0046872" nucleus|cytoplasm|endosome|biological_process|SH3 domain binding|regulation of endocytosis|metal ion binding RUFY3 277.4368025 241.5595205 313.3140845 1.297047137 0.375230911 0.440475491 1 1.515063473 2.049757654 22902 RUN and FYVE domain containing 3 "GO:0005515,GO:0005737,GO:0005829,GO:0007015,GO:0012505,GO:0016020,GO:0030027,GO:0030054,GO:0030175,GO:0030335,GO:0030424,GO:0030425,GO:0030426,GO:0043025,GO:0043204,GO:0045773,GO:0050770,GO:0050771,GO:0071437,GO:0090316,GO:2000114" protein binding|cytoplasm|cytosol|actin filament organization|endomembrane system|membrane|lamellipodium|cell junction|filopodium|positive regulation of cell migration|axon|dendrite|growth cone|neuronal cell body|perikaryon|positive regulation of axon extension|regulation of axonogenesis|negative regulation of axonogenesis|invadopodium|positive regulation of intracellular protein transport|regulation of establishment of cell polarity RUNDC1 878.9793307 1052.509339 705.4493222 0.670254691 -0.577218683 0.109871502 1 9.986115586 6.981558489 146923 RUN domain containing 1 "GO:0001701,GO:0005096,GO:0006886,GO:0090630" in utero embryonic development|GTPase activator activity|intracellular protein transport|activation of GTPase activity RUNDC3A 14.04608002 17.25425146 10.83790858 0.628129746 -0.670865504 0.617463255 1 0.318348622 0.208577887 10900 RUN domain containing 3A "GO:0005515,GO:0005829,GO:0005886,GO:0007264,GO:0010753,GO:0030695,GO:0043231,GO:0050790" protein binding|cytosol|plasma membrane|small GTPase mediated signal transduction|positive regulation of cGMP-mediated signaling|GTPase regulator activity|intracellular membrane-bounded organelle|regulation of catalytic activity RUNDC3B 10.52342568 12.17947162 8.867379749 0.728059478 -0.457871781 0.792994139 1 0.130743381 0.099289312 154661 RUN domain containing 3B RUNX1 1655.850428 1725.425146 1586.275711 0.919353537 -0.121308339 0.712333442 1 10.08618383 9.672202051 861 RUNX family transcription factor 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001503,GO:0001959,GO:0002062,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006357,GO:0010629,GO:0010755,GO:0016513,GO:0030097,GO:0030111,GO:0030182,GO:0030854,GO:0032743,GO:0032967,GO:0033146,GO:0043231,GO:0043371,GO:0043378,GO:0045589,GO:0045595,GO:0045616,GO:0045637,GO:0045652,GO:0045766,GO:0045893,GO:0045944,GO:0048935,GO:0050855,GO:0060043,GO:0061026,GO:0071425,GO:1902036,GO:1903055,GO:1905203,GO:2000810" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|ossification|regulation of cytokine-mediated signaling pathway|chondrocyte differentiation|protein binding|ATP binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|negative regulation of gene expression|regulation of plasminogen activation|core-binding factor complex|hemopoiesis|regulation of Wnt signaling pathway|neuron differentiation|positive regulation of granulocyte differentiation|positive regulation of interleukin-2 production|positive regulation of collagen biosynthetic process|regulation of intracellular estrogen receptor signaling pathway|intracellular membrane-bounded organelle|negative regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|regulation of regulatory T cell differentiation|regulation of cell differentiation|regulation of keratinocyte differentiation|regulation of myeloid cell differentiation|regulation of megakaryocyte differentiation|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|peripheral nervous system neuron development|regulation of B cell receptor signaling pathway|regulation of cardiac muscle cell proliferation|cardiac muscle tissue regeneration|hematopoietic stem cell proliferation|regulation of hematopoietic stem cell differentiation|positive regulation of extracellular matrix organization|regulation of connective tissue replacement|regulation of bicellular tight junction assembly" "hsa04530,hsa04659,hsa05200,hsa05202,hsa05220,hsa05221" Tight junction|Th17 cell differentiation|Pathways in cancer|Transcriptional misregulation in cancer|Chronic myeloid leukemia|Acute myeloid leukemia Runt RUNX2 759.110606 805.8750389 712.3461732 0.88394123 -0.177977641 0.633355324 1 6.967348543 6.424019607 860 RUNX family transcription factor 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001503,GO:0001649,GO:0002062,GO:0003700,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006367,GO:0030097,GO:0030182,GO:0030509,GO:0045595,GO:0045669,GO:0045892,GO:0045893,GO:0045944,GO:0071773,GO:1901522,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|ossification|osteoblast differentiation|chondrocyte differentiation|DNA-binding transcription factor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|hemopoiesis|neuron differentiation|BMP signaling pathway|regulation of cell differentiation|positive regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cellular response to BMP stimulus|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|sequence-specific double-stranded DNA binding" "hsa04928,hsa05202" "Parathyroid hormone synthesis, secretion and action|Transcriptional misregulation in cancer" Runt RUSC1 1440.779724 1167.199364 1714.360085 1.46878086 0.554619164 0.096456689 1 11.66427193 17.8702476 23623 RUN and SH3 domain containing 1 "GO:0000209,GO:0003779,GO:0005515,GO:0005634,GO:0005769,GO:0005794,GO:0005829,GO:0005874,GO:0014069,GO:0015630,GO:0031410" protein polyubiquitination|actin binding|protein binding|nucleus|early endosome|Golgi apparatus|cytosol|microtubule|postsynaptic density|microtubule cytoskeleton|cytoplasmic vesicle RUSC2 1773.021427 1551.867676 1994.175179 1.285016249 0.361786602 0.266485018 1 13.79372115 18.48868363 9853 RUN and SH3 domain containing 2 "GO:0005515,GO:0005829,GO:0008150,GO:0031267,GO:0031410,GO:0070062" protein binding|cytosol|biological_process|small GTPase binding|cytoplasmic vesicle|extracellular exosome RUSF1 1455.845957 1489.955362 1421.736553 0.954214193 -0.06761495 0.840715896 1 27.11497766 26.98802182 64755 RUS family member 1 "GO:0005515,GO:0016020,GO:0016021" protein binding|membrane|integral component of membrane RUVBL1 1228.35256 1328.577363 1128.127757 0.849124627 -0.23595178 0.489264958 1 24.19552552 21.43001257 8607 RuvB like AAA ATPase 1 "GO:0000492,GO:0000812,GO:0001094,GO:0003678,GO:0003713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005815,GO:0005829,GO:0006281,GO:0006310,GO:0006338,GO:0006357,GO:0007049,GO:0007283,GO:0016020,GO:0016363,GO:0016573,GO:0016579,GO:0016887,GO:0017025,GO:0031011,GO:0032508,GO:0034080,GO:0035267,GO:0040008,GO:0043139,GO:0043531,GO:0043967,GO:0043968,GO:0045296,GO:0045893,GO:0051117,GO:0051301,GO:0070062,GO:0071339,GO:0090263,GO:0097255,GO:1904837,GO:1904874,GO:1990904" "box C/D snoRNP assembly|Swr1 complex|TFIID-class transcription factor complex binding|DNA helicase activity|transcription coactivator activity|protein binding|ATP binding|nucleus|nucleoplasm|microtubule organizing center|cytosol|DNA repair|DNA recombination|chromatin remodeling|regulation of transcription by RNA polymerase II|cell cycle|spermatogenesis|membrane|nuclear matrix|histone acetylation|protein deubiquitination|ATPase activity|TBP-class protein binding|Ino80 complex|DNA duplex unwinding|CENP-A containing nucleosome assembly|NuA4 histone acetyltransferase complex|regulation of growth|5'-3' DNA helicase activity|ADP binding|histone H4 acetylation|histone H2A acetylation|cadherin binding|positive regulation of transcription, DNA-templated|ATPase binding|cell division|extracellular exosome|MLL1 complex|positive regulation of canonical Wnt signaling pathway|R2TP complex|beta-catenin-TCF complex assembly|positive regulation of telomerase RNA localization to Cajal body|ribonucleoprotein complex" hsa04310 Wnt signaling pathway RUVBL2 1984.944581 2265.381721 1704.507441 0.752415112 -0.410399271 0.203268385 1 47.82559083 37.53477208 10856 RuvB like AAA ATPase 2 "GO:0000492,GO:0000791,GO:0000812,GO:0000978,GO:0000979,GO:0001094,GO:0003678,GO:0003714,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006281,GO:0006310,GO:0006338,GO:0006357,GO:0006457,GO:0008013,GO:0016020,GO:0016363,GO:0016573,GO:0016887,GO:0017025,GO:0031011,GO:0031490,GO:0032508,GO:0034644,GO:0035066,GO:0035267,GO:0040008,GO:0042802,GO:0042803,GO:0043139,GO:0043531,GO:0043967,GO:0043968,GO:0045892,GO:0045944,GO:0051082,GO:0051117,GO:0070062,GO:0071169,GO:0071339,GO:0071392,GO:0071733,GO:0071899,GO:0090090,GO:0097255,GO:1904874,GO:1990904" "box C/D snoRNP assembly|euchromatin|Swr1 complex|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|TFIID-class transcription factor complex binding|DNA helicase activity|transcription corepressor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA repair|DNA recombination|chromatin remodeling|regulation of transcription by RNA polymerase II|protein folding|beta-catenin binding|membrane|nuclear matrix|histone acetylation|ATPase activity|TBP-class protein binding|Ino80 complex|chromatin DNA binding|DNA duplex unwinding|cellular response to UV|positive regulation of histone acetylation|NuA4 histone acetyltransferase complex|regulation of growth|identical protein binding|protein homodimerization activity|5'-3' DNA helicase activity|ADP binding|histone H4 acetylation|histone H2A acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|unfolded protein binding|ATPase binding|extracellular exosome|establishment of protein localization to chromatin|MLL1 complex|cellular response to estradiol stimulus|transcriptional activation by promoter-enhancer looping|negative regulation of estrogen receptor binding|negative regulation of canonical Wnt signaling pathway|R2TP complex|positive regulation of telomerase RNA localization to Cajal body|ribonucleoprotein complex" RWDD1 503.9664623 505.4480723 502.4848524 0.99413744 -0.008482776 0.988912575 1 4.549344543 4.717492179 51389 RWD domain containing 1 "GO:0002181,GO:0005515,GO:0005844" cytoplasmic translation|protein binding|polysome RWDD2A 236.1771848 216.1856213 256.1687483 1.184948133 0.244823912 0.635800289 1 2.495791899 3.084776057 112611 RWD domain containing 2A GO:0005515 protein binding RWDD2B 230.9930413 265.9184637 196.0676189 0.737322321 -0.439632662 0.393947641 1 4.25792984 3.274702206 10069 RWD domain containing 2B "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process RWDD3 95.92150382 91.34603715 100.4969705 1.100178767 0.137737964 0.854726369 1 3.654308477 4.193574801 25950 RWD domain containing 3 "GO:0005515,GO:0005634,GO:0005737,GO:0032088,GO:0033235,GO:1902073" protein binding|nucleus|cytoplasm|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein sumoylation|positive regulation of hypoxia-inducible factor-1alpha signaling pathway RWDD4 177.9453854 175.5873825 180.3033882 1.026858454 0.038237329 0.956372881 1 3.419024025 3.662087066 201965 RWD domain containing 4 GO:0005515 protein binding RXRA 1975.330953 2079.644779 1871.017127 0.899681112 -0.15251436 0.636962303 1 14.35163803 13.46808985 6256 retinoid X receptor alpha "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001972,GO:0003690,GO:0003700,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0006367,GO:0008203,GO:0008270,GO:0015721,GO:0016922,GO:0019048,GO:0019216,GO:0019899,GO:0030154,GO:0032526,GO:0035357,GO:0042277,GO:0042802,GO:0042809,GO:0043235,GO:0043401,GO:0043565,GO:0044323,GO:0045893,GO:0045944,GO:0048384,GO:0048856,GO:0050692,GO:0050693,GO:0070644,GO:0090575,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|retinoic acid binding|double-stranded DNA binding|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|cholesterol metabolic process|zinc ion binding|bile acid and bile salt transport|nuclear receptor binding|modulation by virus of host process|regulation of lipid metabolic process|enzyme binding|cell differentiation|response to retinoic acid|peroxisome proliferator activated receptor signaling pathway|peptide binding|identical protein binding|vitamin D receptor binding|receptor complex|steroid hormone mediated signaling pathway|sequence-specific DNA binding|retinoic acid-responsive element binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|anatomical structure development|DNA binding domain binding|LBD domain binding|vitamin D response element binding|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa03320,hsa04151,hsa04659,hsa04919,hsa04920,hsa04928,hsa04932,hsa04976,hsa05160,hsa05200,hsa05202,hsa05216,hsa05222,hsa05223,hsa05226" "PPAR signaling pathway|PI3K-Akt signaling pathway|Th17 cell differentiation|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Parathyroid hormone synthesis, secretion and action|Non-alcoholic fatty liver disease|Bile secretion|Hepatitis C|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer" ThyrH_rcpt RXRB 809.8598883 705.394398 914.3253786 1.296190303 0.374277546 0.307347738 1 11.7984603 15.95181239 6257 retinoid X receptor beta "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006367,GO:0008270,GO:0030154,GO:0032526,GO:0043401,GO:0044323,GO:0045893,GO:0045944,GO:0048384,GO:0048856,GO:0090575,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|zinc ion binding|cell differentiation|response to retinoic acid|steroid hormone mediated signaling pathway|retinoic acid-responsive element binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|anatomical structure development|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa03320,hsa04659,hsa04919,hsa04920,hsa04928,hsa05200,hsa05202,hsa05216,hsa05222,hsa05223,hsa05226" "PPAR signaling pathway|Th17 cell differentiation|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer" RXYLT1 261.0287602 264.9035077 257.1540127 0.970745971 -0.042834281 0.93905741 1 5.494032819 5.563047595 10329 ribitol xylosyltransferase 1 "GO:0000139,GO:0005515,GO:0005654,GO:0005794,GO:0005887,GO:0035269,GO:0120053" "Golgi membrane|protein binding|nucleoplasm|Golgi apparatus|integral component of plasma membrane|protein O-linked mannosylation|ribitol beta-1,4-xylosyltransferase activity" hsa00515 Mannose type O-glycan biosynthesis RYBP 756.3126731 884.0266485 628.5986978 0.711063065 -0.491950576 0.185685941 1 10.06357183 7.464078545 23429 RING1 and YY1 binding protein "GO:0000122,GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006915,GO:0007275,GO:0031519,GO:0032435,GO:0035518,GO:0043065,GO:0045893,GO:0046872,GO:0070317" "negative regulation of transcription by RNA polymerase II|DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|apoptotic process|multicellular organism development|PcG protein complex|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|histone H2A monoubiquitination|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of G0 to G1 transition" other RYK 1115.927258 1152.98998 1078.864536 0.935710244 -0.095866246 0.783612715 1 19.09577338 18.63779652 6259 receptor like tyrosine kinase "GO:0004713,GO:0004714,GO:0004888,GO:0005109,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0006468,GO:0007165,GO:0007169,GO:0007275,GO:0007409,GO:0007411,GO:0007416,GO:0016020,GO:0016021,GO:0016055,GO:0017147,GO:0018108,GO:0022008,GO:0022038,GO:0030182,GO:0031175,GO:0033278,GO:0033674,GO:0035567,GO:0036518,GO:0042813,GO:0043235,GO:0043410,GO:0048705,GO:0048843,GO:0060070,GO:0071679,GO:1904929,GO:1904938,GO:1904948,GO:1904953" "protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane signaling receptor activity|frizzled binding|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|protein phosphorylation|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axonogenesis|axon guidance|synapse assembly|membrane|integral component of membrane|Wnt signaling pathway|Wnt-protein binding|peptidyl-tyrosine phosphorylation|neurogenesis|corpus callosum development|neuron differentiation|neuron projection development|cell proliferation in midbrain|positive regulation of kinase activity|non-canonical Wnt signaling pathway|chemorepulsion of dopaminergic neuron axon|Wnt-activated receptor activity|receptor complex|positive regulation of MAPK cascade|skeletal system morphogenesis|negative regulation of axon extension involved in axon guidance|canonical Wnt signaling pathway|commissural neuron axon guidance|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|planar cell polarity pathway involved in axon guidance|midbrain dopaminergic neuron differentiation|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" "hsa04310,hsa04360" Wnt signaling pathway|Axon guidance RYR2 9.538161268 12.17947162 6.896850916 0.566268483 -0.82044186 0.599184136 1 0.037815551 0.022336173 6262 ryanodine receptor 2 "GO:0001666,GO:0002027,GO:0003143,GO:0003220,GO:0003300,GO:0005219,GO:0005262,GO:0005509,GO:0005513,GO:0005515,GO:0005516,GO:0005790,GO:0005886,GO:0006816,GO:0006874,GO:0010460,GO:0010881,GO:0010882,GO:0014701,GO:0014808,GO:0014850,GO:0015278,GO:0016020,GO:0016529,GO:0019722,GO:0019899,GO:0030018,GO:0030659,GO:0031000,GO:0032991,GO:0033017,GO:0034220,GO:0034236,GO:0034237,GO:0034704,GO:0035584,GO:0035994,GO:0042383,GO:0042802,GO:0043621,GO:0043924,GO:0044325,GO:0048763,GO:0051209,GO:0051284,GO:0051480,GO:0051775,GO:0055117,GO:0060048,GO:0060402,GO:0070296,GO:0071313,GO:0071872,GO:0072599,GO:0086005,GO:0086029,GO:0086064,GO:0097050,GO:0098735,GO:0098904,GO:0098907,GO:0098910,GO:0098911,GO:1901896,GO:1903779" response to hypoxia|regulation of heart rate|embryonic heart tube morphogenesis|left ventricular cardiac muscle tissue morphogenesis|cardiac muscle hypertrophy|ryanodine-sensitive calcium-release channel activity|calcium channel activity|calcium ion binding|detection of calcium ion|protein binding|calmodulin binding|smooth endoplasmic reticulum|plasma membrane|calcium ion transport|cellular calcium ion homeostasis|positive regulation of heart rate|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by calcium ion signaling|junctional sarcoplasmic reticulum membrane|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to muscle activity|calcium-release channel activity|membrane|sarcoplasmic reticulum|calcium-mediated signaling|enzyme binding|Z disc|cytoplasmic vesicle membrane|response to caffeine|protein-containing complex|sarcoplasmic reticulum membrane|ion transmembrane transport|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|calcium channel complex|calcium-mediated signaling using intracellular calcium source|response to muscle stretch|sarcolemma|identical protein binding|protein self-association|suramin binding|ion channel binding|calcium-induced calcium release activity|release of sequestered calcium ion into cytosol|positive regulation of sequestering of calcium ion|regulation of cytosolic calcium ion concentration|response to redox state|regulation of cardiac muscle contraction|cardiac muscle contraction|calcium ion transport into cytosol|sarcoplasmic reticulum calcium ion transport|cellular response to caffeine|cellular response to epinephrine stimulus|establishment of protein localization to endoplasmic reticulum|ventricular cardiac muscle cell action potential|Purkinje myocyte to ventricular cardiac muscle cell signaling|cell communication by electrical coupling involved in cardiac conduction|type B pancreatic cell apoptotic process|positive regulation of the force of heart contraction|regulation of AV node cell action potential|regulation of SA node cell action potential|regulation of atrial cardiac muscle cell action potential|regulation of ventricular cardiac muscle cell action potential|positive regulation of ATPase-coupled calcium transmembrane transporter activity|regulation of cardiac conduction "hsa04020,hsa04024,hsa04260,hsa04261,hsa04371,hsa04713,hsa04911,hsa04921,hsa04972,hsa05020,hsa05022,hsa05410,hsa05412,hsa05414" Calcium signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Circadian entrainment|Insulin secretion|Oxytocin signaling pathway|Pancreatic secretion|Prion disease|Pathways of neurodegeneration - multiple diseases|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy S100A1 9.000991732 9.134603715 8.867379749 0.970745971 -0.042834281 1 1 0.827612618 0.838008897 6271 S100 calcium binding protein A1 "GO:0002224,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0008016,GO:0016529,GO:0021762,GO:0032991,GO:0035556,GO:0042802,GO:0042803,GO:0044548,GO:0048306,GO:0051000,GO:0051117,GO:1903672" toll-like receptor signaling pathway|calcium ion binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|regulation of heart contraction|sarcoplasmic reticulum|substantia nigra development|protein-containing complex|intracellular signal transduction|identical protein binding|protein homodimerization activity|S100 protein binding|calcium-dependent protein binding|positive regulation of nitric-oxide synthase activity|ATPase binding|positive regulation of sprouting angiogenesis S100A10 4890.468326 5463.507978 4317.428673 0.79023014 -0.339655222 0.289890118 1 412.3806333 339.913005 6281 S100 calcium binding protein A10 "GO:0001765,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005783,GO:0006900,GO:0008289,GO:0019897,GO:0042493,GO:0042803,GO:0043547,GO:0044325,GO:0045121,GO:0048306,GO:0051099,GO:0051496,GO:0051894,GO:0062023,GO:0070062,GO:0072659,GO:1900026,GO:1990665" membrane raft assembly|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum|vesicle budding from membrane|lipid binding|extrinsic component of plasma membrane|response to drug|protein homodimerization activity|positive regulation of GTPase activity|ion channel binding|membrane raft|calcium-dependent protein binding|positive regulation of binding|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|collagen-containing extracellular matrix|extracellular exosome|protein localization to plasma membrane|positive regulation of substrate adhesion-dependent cell spreading|AnxA2-p11 complex hsa05132 Salmonella infection S100A11 6559.318203 6124.244313 6994.392093 1.142082473 0.191666836 0.556845578 1 550.9260558 656.3065056 6282 S100 calcium binding protein A11 "GO:0001726,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005912,GO:0007165,GO:0008156,GO:0008285,GO:0014911,GO:0034774,GO:0042803,GO:0043312,GO:0044548,GO:0048306,GO:0070062,GO:0098609,GO:0098641" ruffle|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|adherens junction|signal transduction|negative regulation of DNA replication|negative regulation of cell population proliferation|positive regulation of smooth muscle cell migration|secretory granule lumen|protein homodimerization activity|neutrophil degranulation|S100 protein binding|calcium-dependent protein binding|extracellular exosome|cell-cell adhesion|cadherin binding involved in cell-cell adhesion S100A13 1864.096035 1951.760327 1776.431743 0.910168999 -0.135793647 0.675958606 1 52.24618138 49.60123872 6284 S100 calcium binding protein A13 "GO:0001816,GO:0005507,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0008270,GO:0008284,GO:0008289,GO:0008360,GO:0015031,GO:0017134,GO:0032610,GO:0042803,GO:0043123,GO:0043303,GO:0046688,GO:0048306,GO:0048471,GO:0050786,GO:0051602" cytokine production|copper ion binding|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|zinc ion binding|positive regulation of cell population proliferation|lipid binding|regulation of cell shape|protein transport|fibroblast growth factor binding|interleukin-1 alpha production|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|mast cell degranulation|response to copper ion|calcium-dependent protein binding|perinuclear region of cytoplasm|RAGE receptor binding|response to electrical stimulus S100A14 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.222913874 0.225714066 57402 S100 calcium binding protein A14 "GO:0005509,GO:0005515,GO:0005615,GO:0006915,GO:0032496,GO:0034142,GO:0042379,GO:0042742,GO:0048306,GO:0048471,GO:0055074,GO:0070062,GO:0071624,GO:0090026" calcium ion binding|protein binding|extracellular space|apoptotic process|response to lipopolysaccharide|toll-like receptor 4 signaling pathway|chemokine receptor binding|defense response to bacterium|calcium-dependent protein binding|perinuclear region of cytoplasm|calcium ion homeostasis|extracellular exosome|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis S100A16 5927.794641 6294.756916 5560.832367 0.883407007 -0.178849819 0.581190524 1 195.3475681 180.005087 140576 S100 calcium binding protein A16 "GO:0003723,GO:0005509,GO:0005515,GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0042803,GO:0048306,GO:0051592,GO:0070062" RNA binding|calcium ion binding|protein binding|extracellular space|nucleus|nucleolus|cytoplasm|cytosol|plasma membrane|protein homodimerization activity|calcium-dependent protein binding|response to calcium ion|extracellular exosome S100A2 595.7333783 1020.030748 171.4360085 0.168069452 -2.572870571 6.61E-10 6.90E-07 47.00724199 8.240802079 6273 S100 calcium binding protein A2 "GO:0005509,GO:0005515,GO:0005575,GO:0042802,GO:0043542,GO:0046914,GO:0048306" calcium ion binding|protein binding|cellular_component|identical protein binding|endothelial cell migration|transition metal ion binding|calcium-dependent protein binding S100A3 46.0320388 82.21143344 9.852644165 0.119845182 -3.060756189 0.001346748 0.109304316 5.611481239 0.701477948 6274 S100 calcium binding protein A3 "GO:0005509,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0008270,GO:0048306" calcium ion binding|protein binding|Golgi apparatus|cytosol|plasma membrane|zinc ion binding|calcium-dependent protein binding S100A4 46.43559635 76.12169763 16.74949508 0.220035753 -2.18419013 0.015487293 0.550957387 6.859956305 1.57445602 6275 S100 calcium binding protein A4 "GO:0001837,GO:0003723,GO:0003779,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0042802,GO:0043005,GO:0043123,GO:0046914,GO:0048306,GO:0048471,GO:0050786,GO:0062023,GO:0070062" epithelial to mesenchymal transition|RNA binding|actin binding|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|identical protein binding|neuron projection|positive regulation of I-kappaB kinase/NF-kappaB signaling|transition metal ion binding|calcium-dependent protein binding|perinuclear region of cytoplasm|RAGE receptor binding|collagen-containing extracellular matrix|extracellular exosome S100A5 8.612279955 16.23929549 0.985264417 0.060671623 -4.042834281 0.027592916 0.734583991 0.398094399 0.025193448 6276 S100 calcium binding protein A5 "GO:0005507,GO:0005509,GO:0005515,GO:0005634,GO:0008270,GO:0042803,GO:0043025,GO:0048306" copper ion binding|calcium ion binding|protein binding|nucleus|zinc ion binding|protein homodimerization activity|neuronal cell body|calcium-dependent protein binding S100A6 13738.95414 15319.74539 12158.1629 0.793626956 -0.333467066 0.336799806 1 1787.767417 1479.937443 6277 S100 calcium binding protein A6 "GO:0001726,GO:0005509,GO:0005515,GO:0005523,GO:0005576,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0007409,GO:0008270,GO:0015075,GO:0031234,GO:0034220,GO:0042803,GO:0044548,GO:0048146,GO:0048306,GO:0048471,GO:0062023,GO:0070062" ruffle|calcium ion binding|protein binding|tropomyosin binding|extracellular region|nucleus|nuclear envelope|cytoplasm|cytosol|plasma membrane|signal transduction|axonogenesis|zinc ion binding|ion transmembrane transporter activity|extrinsic component of cytoplasmic side of plasma membrane|ion transmembrane transport|protein homodimerization activity|S100 protein binding|positive regulation of fibroblast proliferation|calcium-dependent protein binding|perinuclear region of cytoplasm|collagen-containing extracellular matrix|extracellular exosome S100PBP 583.0493964 590.7043736 575.3944193 0.974081867 -0.037885065 0.927775375 1 5.505537844 5.593854178 64766 S100P binding protein "GO:0005515,GO:0005634,GO:0005829,GO:0016607,GO:0048306" protein binding|nucleus|cytosol|nuclear speck|calcium-dependent protein binding S100Z 6.015506931 7.104691779 4.926322083 0.693389979 -0.528261108 0.84291128 1 0.06836929 0.049448664 170591 S100 calcium binding protein Z "GO:0005509,GO:0005515,GO:0008150,GO:0042803,GO:0048306" calcium ion binding|protein binding|biological_process|protein homodimerization activity|calcium-dependent protein binding S1PR1 124.2687637 109.6152446 138.9222827 1.267362795 0.341829569 0.593326075 1 1.933690505 2.556253077 1901 sphingosine-1-phosphate receptor 1 "GO:0001525,GO:0001664,GO:0001955,GO:0003245,GO:0003376,GO:0004930,GO:0005515,GO:0005654,GO:0005737,GO:0005768,GO:0005886,GO:0006935,GO:0007155,GO:0007186,GO:0007189,GO:0007193,GO:0007420,GO:0009897,GO:0016021,GO:0016477,GO:0019221,GO:0019222,GO:0019226,GO:0030032,GO:0030155,GO:0030182,GO:0030335,GO:0030500,GO:0030595,GO:0031226,GO:0031532,GO:0038036,GO:0043231,GO:0043547,GO:0045121,GO:0045124,GO:0045446,GO:0045944,GO:0046625,GO:0048661,GO:0050927,GO:0051482,GO:0051497,GO:0061384,GO:0072678" angiogenesis|G protein-coupled receptor binding|blood vessel maturation|cardiac muscle tissue growth involved in heart morphogenesis|sphingosine-1-phosphate receptor signaling pathway|G protein-coupled receptor activity|protein binding|nucleoplasm|cytoplasm|endosome|plasma membrane|chemotaxis|cell adhesion|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|brain development|external side of plasma membrane|integral component of membrane|cell migration|cytokine-mediated signaling pathway|regulation of metabolic process|transmission of nerve impulse|lamellipodium assembly|regulation of cell adhesion|neuron differentiation|positive regulation of cell migration|regulation of bone mineralization|leukocyte chemotaxis|intrinsic component of plasma membrane|actin cytoskeleton reorganization|sphingosine-1-phosphate receptor activity|intracellular membrane-bounded organelle|positive regulation of GTPase activity|membrane raft|regulation of bone resorption|endothelial cell differentiation|positive regulation of transcription by RNA polymerase II|sphingolipid binding|positive regulation of smooth muscle cell proliferation|positive regulation of positive chemotaxis|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|negative regulation of stress fiber assembly|heart trabecula morphogenesis|T cell migration "hsa04068,hsa04071,hsa04080" FoxO signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction S1PR2 104.4744007 103.5255088 105.4232926 1.018331557 0.026207363 0.984843976 1 1.439253858 1.528771347 9294 sphingosine-1-phosphate receptor 2 "GO:0000187,GO:0001664,GO:0003376,GO:0004930,GO:0005178,GO:0005515,GO:0005737,GO:0005886,GO:0007186,GO:0007189,GO:0008284,GO:0008289,GO:0010800,GO:0016021,GO:0019222,GO:0031532,GO:0038036,GO:0046847,GO:0090394,GO:1903142" activation of MAPK activity|G protein-coupled receptor binding|sphingosine-1-phosphate receptor signaling pathway|G protein-coupled receptor activity|integrin binding|protein binding|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cell population proliferation|lipid binding|positive regulation of peptidyl-threonine phosphorylation|integral component of membrane|regulation of metabolic process|actin cytoskeleton reorganization|sphingosine-1-phosphate receptor activity|filopodium assembly|negative regulation of excitatory postsynaptic potential|positive regulation of establishment of endothelial barrier "hsa04071,hsa04080" Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction S1PR3 449.9511094 382.6384001 517.2638187 1.351834574 0.434918618 0.300673107 1 4.475585473 6.310871466 1903 sphingosine-1-phosphate receptor 3 "GO:0003376,GO:0004930,GO:0005178,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007189,GO:0007193,GO:0007204,GO:0007219,GO:0008284,GO:0008289,GO:0009653,GO:0019222,GO:0032651,GO:0038036,GO:1903141" sphingosine-1-phosphate receptor signaling pathway|G protein-coupled receptor activity|integrin binding|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|Notch signaling pathway|positive regulation of cell population proliferation|lipid binding|anatomical structure morphogenesis|regulation of metabolic process|regulation of interleukin-1 beta production|sphingosine-1-phosphate receptor activity|negative regulation of establishment of endothelial barrier "hsa04071,hsa04080" Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction S1PR5 124.3429925 114.6900244 133.9959607 1.168331434 0.224449598 0.730387692 1 2.342195619 2.854336397 53637 sphingosine-1-phosphate receptor 5 "GO:0003376,GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0007186,GO:0007189,GO:0016021,GO:0019222,GO:0038036,GO:0045664" sphingosine-1-phosphate receptor signaling pathway|G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|integral component of membrane|regulation of metabolic process|sphingosine-1-phosphate receptor activity|regulation of neuron differentiation "hsa04071,hsa04080" Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction SAA1 508.4795782 813.9946866 202.9644698 0.249343728 -2.003792181 2.07E-06 0.000796583 71.20200221 18.5185332 6288 serum amyloid A1 "GO:0000187,GO:0001664,GO:0001819,GO:0005576,GO:0005881,GO:0006898,GO:0006953,GO:0007186,GO:0007204,GO:0008201,GO:0019221,GO:0030168,GO:0030593,GO:0032732,GO:0034364,GO:0044267,GO:0045087,GO:0045785,GO:0048246,GO:0048247,GO:0050708,GO:0050728,GO:0070062,GO:0071682" activation of MAPK activity|G protein-coupled receptor binding|positive regulation of cytokine production|extracellular region|cytoplasmic microtubule|receptor-mediated endocytosis|acute-phase response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|heparin binding|cytokine-mediated signaling pathway|platelet activation|neutrophil chemotaxis|positive regulation of interleukin-1 production|high-density lipoprotein particle|cellular protein metabolic process|innate immune response|positive regulation of cell adhesion|macrophage chemotaxis|lymphocyte chemotaxis|regulation of protein secretion|negative regulation of inflammatory response|extracellular exosome|endocytic vesicle lumen SAA2 21.68794134 34.50850292 8.867379749 0.256962169 -1.960372121 0.079188976 1 0.737129454 0.197573586 6289 serum amyloid A2 "GO:0005515,GO:0006953,GO:0034364,GO:0070062" protein binding|acute-phase response|high-density lipoprotein particle|extracellular exosome SAAL1 551.595164 595.7791534 507.4111745 0.851676618 -0.231622352 0.563048219 1 19.18252533 17.04105328 113174 serum amyloid A like 1 "GO:0003674,GO:0005634,GO:0005654,GO:1901647" molecular_function|nucleus|nucleoplasm|positive regulation of synoviocyte proliferation SAC3D1 519.597081 496.3134685 542.8806935 1.093826237 0.129383572 0.752532447 1 15.95969923 18.20912045 29901 SAC3 domain containing 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0051225,GO:0051298,GO:0051301" protein binding|nucleus|cytoplasm|centrosome|spindle|spindle assembly|centrosome duplication|cell division SACM1L 952.4221077 920.5650633 984.2791521 1.069211934 0.096547846 0.788107858 1 12.78052985 14.25373192 22908 SAC1 like phosphatidylinositide phosphatase "GO:0000139,GO:0004438,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006661,GO:0016021,GO:0016791,GO:0034596,GO:0043812,GO:0046856,GO:0140268" Golgi membrane|phosphatidylinositol-3-phosphatase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|phosphatidylinositol biosynthetic process|integral component of membrane|phosphatase activity|phosphatidylinositol phosphate 4-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity|phosphatidylinositol dephosphorylation|endoplasmic reticulum-plasma membrane contact site "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system SACS 3013.125653 2841.876711 3184.374594 1.120518206 0.16416609 0.606178216 1 9.018234956 10.54038303 26278 sacsin molecular chaperone "GO:0005634,GO:0005737,GO:0005739,GO:0006457,GO:0030424,GO:0030425,GO:0030544,GO:0051087,GO:0070628,GO:0070852,GO:0090084" nucleus|cytoplasm|mitochondrion|protein folding|axon|dendrite|Hsp70 protein binding|chaperone binding|proteasome binding|cell body fiber|negative regulation of inclusion body assembly SAE1 2878.072921 2803.308385 2952.837456 1.053340215 0.074971483 0.814583273 1 56.29567018 61.85283193 10055 SUMO1 activating enzyme subunit 1 "GO:0004839,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008022,GO:0008047,GO:0016567,GO:0016925,GO:0018215,GO:0019948,GO:0031510,GO:0032446,GO:0033235,GO:0043008,GO:0044388,GO:0046982,GO:0050790,GO:1903955" ubiquitin activating enzyme activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein C-terminus binding|enzyme activator activity|protein ubiquitination|protein sumoylation|protein phosphopantetheinylation|SUMO activating enzyme activity|SUMO activating enzyme complex|protein modification by small protein conjugation|positive regulation of protein sumoylation|ATP-dependent protein binding|small protein activating enzyme binding|protein heterodimerization activity|regulation of catalytic activity|positive regulation of protein targeting to mitochondrion hsa04120 Ubiquitin mediated proteolysis SAFB 1559.985586 1671.63248 1448.338692 0.866421722 -0.206858681 0.531210135 1 27.61327069 24.95531822 6294 scaffold attachment factor B "GO:0000978,GO:0003682,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006357,GO:0030496,GO:0030520,GO:0043565,GO:0050684" RNA polymerase II cis-regulatory region sequence-specific DNA binding|chromatin binding|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|midbody|intracellular estrogen receptor signaling pathway|sequence-specific DNA binding|regulation of mRNA processing SAFB2 793.2128298 914.4753275 671.9503321 0.734793287 -0.444589648 0.227123089 1 13.11295279 10.05035975 9667 scaffold attachment factor B2 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0016604,GO:0042802,GO:0043231,GO:0043565,GO:0050684,GO:0060008,GO:0060765,GO:0070062" RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|nuclear body|identical protein binding|intracellular membrane-bounded organelle|sequence-specific DNA binding|regulation of mRNA processing|Sertoli cell differentiation|regulation of androgen receptor signaling pathway|extracellular exosome SALL2 406.3470969 365.3841486 447.3100451 1.224218529 0.29186111 0.500650383 1 3.604483469 4.602755614 6297 spalt like transcription factor 2 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0005515,GO:0005634,GO:0006357,GO:0021915,GO:0044877,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|protein binding|nucleus|regulation of transcription by RNA polymerase II|neural tube development|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|metal ion binding" SALL4 289.1533334 267.9483757 310.3582912 1.158276442 0.211979618 0.661659208 1 2.091007698 2.526293385 57167 spalt like transcription factor 4 "GO:0000122,GO:0000792,GO:0000978,GO:0000981,GO:0001833,GO:0001843,GO:0003281,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0008134,GO:0030326,GO:0032991,GO:0035019,GO:0043231,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|inner cell mass cell proliferation|neural tube closure|ventricular septum development|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|embryonic limb morphogenesis|protein-containing complex|somatic stem cell population maintenance|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 SAMD1 677.2797196 734.8281211 619.731318 0.843369082 -0.245763961 0.519356928 1 16.94738252 14.90857854 90378 sterile alpha motif domain containing 1 "GO:0003682,GO:0005576,GO:0005634,GO:0005737,GO:0042393,GO:0045892" "chromatin binding|extracellular region|nucleus|cytoplasm|histone binding|negative regulation of transcription, DNA-templated" SAMD10 194.1725567 173.5574706 214.7876428 1.23755919 0.307497529 0.57589865 1 2.718859762 3.509689665 140700 sterile alpha motif domain containing 10 SAMD11 26.13647699 35.52345889 16.74949508 0.471505186 -1.084654457 0.295603888 1 0.501711621 0.246749661 148398 sterile alpha motif domain containing 11 "GO:0003682,GO:0005515,GO:0005634,GO:0042393,GO:0045892" "chromatin binding|protein binding|nucleus|histone binding|negative regulation of transcription, DNA-templated" SAMD12 367.8421125 427.2964627 308.3877624 0.721718501 -0.470491857 0.289992398 1 1.975991456 1.487540608 401474 sterile alpha motif domain containing 12 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process SAMD13 12.98658673 12.17947162 13.79370183 1.132536966 0.17955814 0.952676516 1 0.372267514 0.439767829 148418 sterile alpha motif domain containing 13 "GO:0003682,GO:0005634,GO:0042393,GO:0045892" "chromatin binding|nucleus|histone binding|negative regulation of transcription, DNA-templated" SAMD14 176.2002648 157.3181751 195.0823545 1.240049691 0.310397934 0.584842098 1 1.206848013 1.561016876 201191 sterile alpha motif domain containing 14 "GO:0005737,GO:0007015,GO:0014069,GO:0015629,GO:0019722,GO:0030425,GO:0031175,GO:0051015" cytoplasm|actin filament organization|postsynaptic density|actin cytoskeleton|calcium-mediated signaling|dendrite|neuron projection development|actin filament binding SAMD15 53.19883529 66.98709391 39.41057666 0.588330891 -0.765300306 0.360622444 1 1.598803011 0.981143519 161394 sterile alpha motif domain containing 15 SAMD4A 1356.86078 1256.515489 1457.206072 1.159719944 0.213776457 0.525124317 1 8.299175377 10.03931307 23034 sterile alpha motif domain containing 4A "GO:0000289,GO:0000932,GO:0001650,GO:0003723,GO:0003729,GO:0005515,GO:0005829,GO:0017148,GO:0030054,GO:0030371,GO:0030425,GO:0043488,GO:0045202,GO:0045727" nuclear-transcribed mRNA poly(A) tail shortening|P-body|fibrillar center|RNA binding|mRNA binding|protein binding|cytosol|negative regulation of translation|cell junction|translation repressor activity|dendrite|regulation of mRNA stability|synapse|positive regulation of translation SAMD4B 1826.885601 1698.021335 1955.749867 1.15178168 0.203867281 0.53038038 1 7.603111163 9.134345545 55095 sterile alpha motif domain containing 4B "GO:0000289,GO:0000932,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005829,GO:0017148,GO:0030371,GO:0043488" nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA binding|mRNA binding|protein binding|nucleus|cytosol|negative regulation of translation|translation repressor activity|regulation of mRNA stability SAMD5 40.0044077 40.59823873 39.41057666 0.970745971 -0.042834281 0.993738277 1 0.287735456 0.291349923 389432 sterile alpha motif domain containing 5 GO:0005737 cytoplasm SAMD8 1936.603528 1755.873825 2117.333231 1.205857278 0.270059164 0.403314545 1 13.06239937 16.42989532 142891 sterile alpha motif domain containing 8 "GO:0002950,GO:0003674,GO:0005783,GO:0005789,GO:0005829,GO:0005887,GO:0006686,GO:0016021,GO:0030148,GO:0030173,GO:0030176,GO:0033188,GO:0046513,GO:0047493,GO:2000303" ceramide phosphoethanolamine synthase activity|molecular_function|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|integral component of plasma membrane|sphingomyelin biosynthetic process|integral component of membrane|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|sphingomyelin synthase activity|ceramide biosynthetic process|ceramide cholinephosphotransferase activity|regulation of ceramide biosynthetic process SAMD9 354.860969 348.1298972 361.5920409 1.038669887 0.054737205 0.909224856 1 2.590589357 2.80667449 54809 sterile alpha motif domain containing 9 "GO:0005515,GO:0005737,GO:0005829,GO:0034058,GO:0043231" protein binding|cytoplasm|cytosol|endosomal vesicle fusion|intracellular membrane-bounded organelle SAMD9L 206.3520283 197.9164138 214.7876428 1.085244213 0.11801973 0.832720517 1 1.401925616 1.586968768 219285 sterile alpha motif domain containing 9 like "GO:0005515,GO:0005737,GO:0005769" protein binding|cytoplasm|early endosome SAMHD1 2496.276032 3072.271716 1920.280348 0.625035975 -0.677988866 0.034127599 0.828970386 26.07233983 16.99812241 25939 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 "GO:0000724,GO:0003676,GO:0003697,GO:0003723,GO:0004540,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005886,GO:0006203,GO:0006955,GO:0006974,GO:0008270,GO:0008832,GO:0009264,GO:0016032,GO:0016446,GO:0016793,GO:0032567,GO:0035861,GO:0042802,GO:0045088,GO:0046061,GO:0051289,GO:0051607,GO:0060337,GO:0060339,GO:0090501,GO:0097197,GO:0110025" double-strand break repair via homologous recombination|nucleic acid binding|single-stranded DNA binding|RNA binding|ribonuclease activity|protein binding|GTP binding|nucleus|nucleoplasm|plasma membrane|dGTP catabolic process|immune response|cellular response to DNA damage stimulus|zinc ion binding|dGTPase activity|deoxyribonucleotide catabolic process|viral process|somatic hypermutation of immunoglobulin genes|triphosphoric monoester hydrolase activity|dGTP binding|site of double-strand break|identical protein binding|regulation of innate immune response|dATP catabolic process|protein homotetramerization|defense response to virus|type I interferon signaling pathway|negative regulation of type I interferon-mediated signaling pathway|RNA phosphodiester bond hydrolysis|tetraspanin-enriched microdomain|DNA strand resection involved in replication fork processing hsa05170 Human immunodeficiency virus 1 infection SAMM50 1135.122347 1185.468571 1084.776123 0.915061056 -0.128060087 0.712039428 1 35.48451598 33.86919606 25813 SAMM50 sorting and assembly machinery component "GO:0001401,GO:0005515,GO:0005739,GO:0005741,GO:0007007,GO:0016021,GO:0033108,GO:0034622,GO:0042407,GO:0045040,GO:0070062,GO:0140275" SAM complex|protein binding|mitochondrion|mitochondrial outer membrane|inner mitochondrial membrane organization|integral component of membrane|mitochondrial respiratory chain complex assembly|cellular protein-containing complex assembly|cristae formation|protein insertion into mitochondrial outer membrane|extracellular exosome|MIB complex SAP130 1105.409276 1073.823415 1136.995137 1.058828781 0.082469315 0.813958777 1 12.57174474 13.88472305 79595 Sin3A associated protein 130 "GO:0000122,GO:0016607,GO:0070822" negative regulation of transcription by RNA polymerase II|nuclear speck|Sin3-type complex SAP18 1789.996085 1904.057397 1675.934773 0.880191309 -0.184110968 0.571816712 1 38.71288239 35.54254435 10284 Sin3A associated protein 18 "GO:0000118,GO:0000381,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006397,GO:0008134,GO:0008380,GO:0016604,GO:0016607,GO:0035145,GO:0043065,GO:0045892,GO:0048025,GO:0061574" "histone deacetylase complex|regulation of alternative mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|mRNA processing|transcription factor binding|RNA splicing|nuclear body|nuclear speck|exon-exon junction complex|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|negative regulation of mRNA splicing, via spliceosome|ASAP complex" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway SAP25 5.941278051 2.029911937 9.852644165 4.853729853 2.279093814 0.221443742 1 0.078659433 0.398237672 100316904 Sin3A associated protein 25 "GO:0005634,GO:0005737,GO:0006355" "nucleus|cytoplasm|regulation of transcription, DNA-templated" SAP30 246.5912468 288.247495 204.9349986 0.71096888 -0.492141683 0.329112157 1 13.30785665 9.869033775 8819 Sin3A associated protein 30 "GO:0000118,GO:0000122,GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005654,GO:0006355,GO:0035914,GO:0046872" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|skeletal muscle cell differentiation|metal ion binding" hsa05169 Epstein-Barr virus infection other SAP30BP 1329.20855 1319.442759 1338.974342 1.014802903 0.021199552 0.952195771 1 21.16728572 22.40592112 29115 SAP30 binding protein "GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006915,GO:0010942,GO:0045111" "protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|apoptotic process|positive regulation of cell death|intermediate filament cytoskeleton" SAP30L 729.6459536 576.49499 882.7969172 1.531317587 0.614773521 0.10097643 1 4.720685124 7.540258477 79685 SAP30 like "GO:0000118,GO:0001650,GO:0003677,GO:0003712,GO:0005515,GO:0005654,GO:0005730,GO:0006355,GO:0008270,GO:0010314,GO:0031491,GO:0042393,GO:0044378" "histone deacetylase complex|fibrillar center|DNA binding|transcription coregulator activity|protein binding|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|zinc ion binding|phosphatidylinositol-5-phosphate binding|nucleosome binding|histone binding|non-sequence-specific DNA binding, bending" hsa05169 Epstein-Barr virus infection SAPCD1 41.90070765 35.52345889 48.27795641 1.359044359 0.442592546 0.63434444 1 1.9662709 2.78735904 401251 suppressor APC domain containing 1 SAPCD2 711.1686593 896.2061201 526.1311984 0.587064947 -0.768407977 0.041771068 0.937359354 11.6264545 7.119498058 89958 suppressor APC domain containing 2 "GO:0000132,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0005923,GO:0008284,GO:0016324,GO:0043296,GO:0045179,GO:0090175,GO:0098725,GO:1904777" establishment of mitotic spindle orientation|protein binding|nucleoplasm|nucleolus|cytosol|bicellular tight junction|positive regulation of cell population proliferation|apical plasma membrane|apical junction complex|apical cortex|regulation of establishment of planar polarity|symmetric cell division|negative regulation of protein localization to cell cortex SAR1A 3482.161004 3518.852342 3445.469665 0.979145849 -0.030404322 0.924739658 1 29.84217304 30.47851205 56681 secretion associated Ras related GTPase 1A "GO:0000139,GO:0003400,GO:0003924,GO:0005515,GO:0005525,GO:0006886,GO:0006888,GO:0016050,GO:0030127,GO:0061024,GO:0070863,GO:0070971,GO:0090110" Golgi membrane|regulation of COPII vesicle coating|GTPase activity|protein binding|GTP binding|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|vesicle organization|COPII vesicle coat|membrane organization|positive regulation of protein exit from endoplasmic reticulum|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading "hsa04141,hsa05134" Protein processing in endoplasmic reticulum|Legionellosis SAR1B 908.3700003 906.3556798 910.3843209 1.004444879 0.006398395 0.989237923 1 6.917377599 7.247421529 51128 secretion associated Ras related GTPase 1B "GO:0002474,GO:0003400,GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0012507,GO:0016050,GO:0019886,GO:0030127,GO:0032580,GO:0046872,GO:0048208,GO:0061024,GO:0070863,GO:0070971" antigen processing and presentation of peptide antigen via MHC class I|regulation of COPII vesicle coating|GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|vesicle organization|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|Golgi cisterna membrane|metal ion binding|COPII vesicle coating|membrane organization|positive regulation of protein exit from endoplasmic reticulum|endoplasmic reticulum exit site "hsa04141,hsa05134" Protein processing in endoplasmic reticulum|Legionellosis SARAF 2708.390197 2721.096951 2695.683444 0.990660565 -0.01353727 0.96735479 1 43.32409969 44.7682741 51669 store-operated calcium entry associated regulatory factor "GO:0005515,GO:0005783,GO:0006816,GO:0030176,GO:0140268,GO:2001256" protein binding|endoplasmic reticulum|calcium ion transport|integral component of endoplasmic reticulum membrane|endoplasmic reticulum-plasma membrane contact site|regulation of store-operated calcium entry SARDH 49.82463871 72.06187375 27.58740366 0.382829397 -1.385226479 0.105834939 1 0.833450488 0.332813561 1757 sarcosine dehydrogenase "GO:0005737,GO:0005739,GO:0005759,GO:0008480,GO:0016491,GO:0042426,GO:0055114,GO:1901053" cytoplasm|mitochondrion|mitochondrial matrix|sarcosine dehydrogenase activity|oxidoreductase activity|choline catabolic process|oxidation-reduction process|sarcosine catabolic process hsa00260 "Glycine, serine and threonine metabolism" SARM1 573.7366434 560.2556945 587.2175923 1.048124273 0.067809782 0.867760256 1 2.761017268 3.018546226 23098 sterile alpha and TIR motif containing 1 "GO:0003953,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0007165,GO:0007399,GO:0009749,GO:0019677,GO:0030154,GO:0030424,GO:0030425,GO:0031315,GO:0034128,GO:0035591,GO:0042981,GO:0045087,GO:0045202,GO:0048678,GO:0048814,GO:0050135,GO:0061809,GO:1901214,GO:1901216" "NAD+ nucleosidase activity|protein binding|cytoplasm|mitochondrion|cytosol|microtubule|signal transduction|nervous system development|response to glucose|NAD catabolic process|cell differentiation|axon|dendrite|extrinsic component of mitochondrial outer membrane|negative regulation of MyD88-independent toll-like receptor signaling pathway|signaling adaptor activity|regulation of apoptotic process|innate immune response|synapse|response to axon injury|regulation of dendrite morphogenesis|NAD(P)+ nucleosidase activity|NAD+ nucleotidase, cyclic ADP-ribose generating|regulation of neuron death|positive regulation of neuron death" SARNP 743.6393315 691.1850145 796.0936486 1.151780828 0.203866213 0.58598795 1 38.98227464 46.83310498 84324 SAP domain containing ribonucleoprotein "GO:0000346,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006405,GO:0006406,GO:0006417,GO:0016607,GO:0016973,GO:0031124,GO:0036464" transcription export complex|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|regulation of translation|nuclear speck|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|cytoplasmic ribonucleoprotein granule SARS1 3768.122741 3198.126256 4338.119226 1.356456524 0.439842809 0.167537703 1 80.78494393 114.3015807 6301 seryl-tRNA synthetase 1 "GO:0000049,GO:0000122,GO:0000978,GO:0003723,GO:0004828,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006434,GO:0008033,GO:0016259,GO:0016525,GO:0019899,GO:0042803,GO:0070062,GO:0097056,GO:1904046" tRNA binding|negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA binding|serine-tRNA ligase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|seryl-tRNA aminoacylation|tRNA processing|selenocysteine metabolic process|negative regulation of angiogenesis|enzyme binding|protein homodimerization activity|extracellular exosome|selenocysteinyl-tRNA(Sec) biosynthetic process|negative regulation of vascular endothelial growth factor production hsa00970 Aminoacyl-tRNA biosynthesis SARS2 271.0298622 275.0530674 267.0066569 0.970745971 -0.042834281 0.938000897 1 7.217858827 7.308527909 54938 "seryl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0003723,GO:0004828,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006434,GO:0070158,GO:0097056" tRNA binding|RNA binding|serine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|seryl-tRNA aminoacylation|mitochondrial seryl-tRNA aminoacylation|selenocysteinyl-tRNA(Sec) biosynthetic process hsa00970 Aminoacyl-tRNA biosynthesis SART1 1724.756833 1754.858869 1694.654796 0.965692926 -0.050363585 0.878968066 1 33.76801328 34.01421792 9092 "spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP" "GO:0000387,GO:0000398,GO:0000481,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0015030,GO:0016607,GO:0045292,GO:0045585,GO:0046540,GO:0071005,GO:0071013" "spliceosomal snRNP assembly|mRNA splicing, via spliceosome|maturation of 5S rRNA|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|Cajal body|nuclear speck|mRNA cis splicing, via spliceosome|positive regulation of cytotoxic T cell differentiation|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SART3 1620.48483 1732.529838 1508.439822 0.870657341 -0.199823057 0.543536462 1 20.75367178 18.84769043 9733 "spliceosome associated factor 3, U4/U6 recycling protein" "GO:0000244,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005691,GO:0005737,GO:0006334,GO:0010468,GO:0015030,GO:0016607,GO:0017070,GO:0030621,GO:0030624,GO:0042393,GO:0046540,GO:0061574,GO:0071001,GO:0071002,GO:1903586,GO:1990381" "spliceosomal tri-snRNP complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U6atac snRNP|cytoplasm|nucleosome assembly|regulation of gene expression|Cajal body|nuclear speck|U6 snRNA binding|U4 snRNA binding|U6atac snRNA binding|histone binding|U4/U6 x U5 tri-snRNP complex|ASAP complex|U4/U6 snRNP|U4atac/U6atac snRNP|positive regulation of histone deubiquitination|ubiquitin-specific protease binding" SASH1 620.1843639 670.8858951 569.4828328 0.848851998 -0.23641506 0.543657018 1 3.086103891 2.732489157 23328 SAM and SH3 domain containing 1 "GO:0000209,GO:0001965,GO:0005515,GO:0005737,GO:0008022,GO:0010595,GO:0010632,GO:0019901,GO:0031435,GO:0031666,GO:0032991,GO:0043507,GO:0045766,GO:0060090,GO:1900044,GO:1900745,GO:1901224,GO:1902498" protein polyubiquitination|G-protein alpha-subunit binding|protein binding|cytoplasm|protein C-terminus binding|positive regulation of endothelial cell migration|regulation of epithelial cell migration|protein kinase binding|mitogen-activated protein kinase kinase kinase binding|positive regulation of lipopolysaccharide-mediated signaling pathway|protein-containing complex|positive regulation of JUN kinase activity|positive regulation of angiogenesis|molecular adaptor activity|regulation of protein K63-linked ubiquitination|positive regulation of p38MAPK cascade|positive regulation of NIK/NF-kappaB signaling|regulation of protein autoubiquitination SASS6 389.7487811 342.0401613 437.4574009 1.278965018 0.354976804 0.417549007 1 3.53677573 4.718262696 163786 SAS-6 centriolar assembly protein "GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0034451,GO:0051298,GO:0098536" protein binding|centrosome|centriole|cytosol|centriole replication|centriolar satellite|centrosome duplication|deuterosome SAT1 1582.837187 1347.861526 1817.812849 1.348664394 0.431531388 0.190394289 1 27.38244337 38.52050924 6303 spermidine/spermine N1-acetyltransferase 1 "GO:0001525,GO:0004145,GO:0005515,GO:0005829,GO:0006596,GO:0008080,GO:0009447,GO:0019809,GO:0032918,GO:0042802" angiogenesis|diamine N-acetyltransferase activity|protein binding|cytosol|polyamine biosynthetic process|N-acetyltransferase activity|putrescine catabolic process|spermidine binding|spermidine acetylation|identical protein binding "hsa00330,hsa04216" Arginine and proline metabolism|Ferroptosis SAT2 706.7567422 628.2577444 785.25574 1.249894246 0.321806034 0.393738753 1 30.89227029 40.27532231 112483 spermidine/spermine N1-acetyltransferase family member 2 "GO:0004145,GO:0005515,GO:0005737,GO:0006596,GO:0008080,GO:0019809,GO:0032918,GO:0032919,GO:0032920,GO:0042802,GO:0046204,GO:0070062" diamine N-acetyltransferase activity|protein binding|cytoplasm|polyamine biosynthetic process|N-acetyltransferase activity|spermidine binding|spermidine acetylation|spermine acetylation|putrescine acetylation|identical protein binding|nor-spermidine metabolic process|extracellular exosome "hsa00330,hsa04216" Arginine and proline metabolism|Ferroptosis SATB1 9.941718821 6.08973581 13.79370183 2.265073931 1.17955814 0.420176302 1 0.029154328 0.068881302 6304 SATB homeobox 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006338,GO:0006357,GO:0016032,GO:0016363,GO:0016604,GO:0016605,GO:0043565" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|chromatin remodeling|regulation of transcription by RNA polymerase II|viral process|nuclear matrix|nuclear body|PML body|sequence-specific DNA binding" SATB2 534.8214206 526.7621476 542.8806935 1.030599287 0.043483499 0.918518631 1 4.043444145 4.346675463 23314 SATB homeobox 2 "GO:0000118,GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001764,GO:0002076,GO:0003682,GO:0005515,GO:0005654,GO:0005667,GO:0006338,GO:0006357,GO:0009880,GO:0016363,GO:0021902,GO:0042826,GO:0045944,GO:0048704,GO:0051216,GO:0060021,GO:0071310" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|neuron migration|osteoblast development|chromatin binding|protein binding|nucleoplasm|transcription regulator complex|chromatin remodeling|regulation of transcription by RNA polymerase II|embryonic pattern specification|nuclear matrix|commitment of neuronal cell to specific neuron type in forebrain|histone deacetylase binding|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|cartilage development|roof of mouth development|cellular response to organic substance" SAV1 1398.677857 1218.962118 1578.393595 1.294866815 0.372803715 0.265269558 1 15.73295898 21.24963335 60485 salvador family WW domain containing protein 1 "GO:0001942,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006915,GO:0007165,GO:0030159,GO:0030216,GO:0030425,GO:0031697,GO:0035329,GO:0042802,GO:0043065,GO:0043113,GO:0045600,GO:0046332,GO:0050680,GO:0050821,GO:0051091,GO:0060044,GO:0060412,GO:0060487,GO:0060575,GO:0070699,GO:2000036" hair follicle development|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|cell-cell junction|apoptotic process|signal transduction|signaling receptor complex adaptor activity|keratinocyte differentiation|dendrite|beta-1 adrenergic receptor binding|hippo signaling|identical protein binding|positive regulation of apoptotic process|receptor clustering|positive regulation of fat cell differentiation|SMAD binding|negative regulation of epithelial cell proliferation|protein stabilization|positive regulation of DNA-binding transcription factor activity|negative regulation of cardiac muscle cell proliferation|ventricular septum morphogenesis|lung epithelial cell differentiation|intestinal epithelial cell differentiation|type II activin receptor binding|regulation of stem cell population maintenance "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species SAXO2 14.52386645 16.23929549 12.80843742 0.788731101 -0.342394563 0.827932218 1 0.212522746 0.174843832 283726 stabilizer of axonemal microtubules 2 "GO:0005515,GO:0005814,GO:0005856,GO:0005879,GO:0008017,GO:0034453,GO:0036064,GO:0036126" protein binding|centriole|cytoskeleton|axonemal microtubule|microtubule binding|microtubule anchoring|ciliary basal body|sperm flagellum SAYSD1 157.6583902 169.4976467 145.8191336 0.860301818 -0.217085208 0.716469525 1 1.33610239 1.198965016 55776 SAYSVFN motif domain containing 1 "GO:0016021,GO:0030659,GO:0043231" integral component of membrane|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle SBDS 1124.713728 1046.419603 1203.007853 1.14964193 0.201184586 0.561276065 1 32.85645466 39.4002724 51119 SBDS ribosome maturation factor "GO:0000922,GO:0001833,GO:0002244,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0007052,GO:0008017,GO:0019843,GO:0030282,GO:0030595,GO:0042256,GO:0043022,GO:0048539" spindle pole|inner cell mass cell proliferation|hematopoietic progenitor cell differentiation|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|mitotic spindle organization|microtubule binding|rRNA binding|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|ribosome binding|bone marrow development hsa03008 Ribosome biogenesis in eukaryotes SBF1 4490.638271 3893.371095 5087.905447 1.306812354 0.386051999 0.227578086 1 24.33487732 33.17098154 6305 SET binding factor 1 "GO:0005085,GO:0005737,GO:0005789,GO:0005829,GO:0006470,GO:0006661,GO:0007283,GO:0008138,GO:0016020,GO:0016021,GO:0016604,GO:0016791,GO:0019208,GO:0043087,GO:0048471" guanyl-nucleotide exchange factor activity|cytoplasm|endoplasmic reticulum membrane|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|spermatogenesis|protein tyrosine/serine/threonine phosphatase activity|membrane|integral component of membrane|nuclear body|phosphatase activity|phosphatase regulator activity|regulation of GTPase activity|perinuclear region of cytoplasm SBF2 1582.252759 1375.265337 1789.24018 1.301014526 0.37963707 0.249283718 1 6.135688661 8.326478972 81846 SET binding factor 2 "GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0006914,GO:0010008,GO:0016020,GO:0019208,GO:0030424,GO:0042552,GO:0043087,GO:0048471" guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|autophagy|endosome membrane|membrane|phosphatase regulator activity|axon|myelination|regulation of GTPase activity|perinuclear region of cytoplasm SBK1 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.02631152 0.044403398 388228 SH3 domain binding kinase 1 "GO:0004674,GO:0005524,GO:0005737,GO:0018105,GO:0018107,GO:0106310,GO:0106311" protein serine/threonine kinase activity|ATP binding|cytoplasm|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein serine kinase activity|protein threonine kinase activity SBNO1 1736.076487 1888.833057 1583.319917 0.838252969 -0.254542408 0.435365508 1 8.596578985 7.516517755 55206 strawberry notch homolog 1 "GO:0003674,GO:0005575,GO:0005634,GO:0006355,GO:0008150,GO:0031490,GO:0042393" "molecular_function|cellular_component|nucleus|regulation of transcription, DNA-templated|biological_process|chromatin DNA binding|histone binding" SBNO2 2530.316643 2469.387871 2591.245416 1.049347268 0.069492198 0.828498098 1 24.81956424 27.16622654 22904 strawberry notch homolog 2 "GO:0002281,GO:0005575,GO:0005634,GO:0006355,GO:0030282,GO:0030316,GO:0031490,GO:0042393,GO:0045892,GO:0045944,GO:0050727,GO:0061430,GO:0071222,GO:0071348,GO:0071354,GO:0072675,GO:1990830" "macrophage activation involved in immune response|cellular_component|nucleus|regulation of transcription, DNA-templated|bone mineralization|osteoclast differentiation|chromatin DNA binding|histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of inflammatory response|bone trabecula morphogenesis|cellular response to lipopolysaccharide|cellular response to interleukin-11|cellular response to interleukin-6|osteoclast fusion|cellular response to leukemia inhibitory factor" SC5D 732.5666121 641.452172 823.6810522 1.284088024 0.360744103 0.335164244 1 4.587952211 6.145109287 6309 sterol-C5-desaturase "GO:0000248,GO:0005506,GO:0005789,GO:0006629,GO:0016020,GO:0016021,GO:0016126,GO:0016491,GO:0033489,GO:0033490,GO:0045540,GO:0055114" C-5 sterol desaturase activity|iron ion binding|endoplasmic reticulum membrane|lipid metabolic process|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|regulation of cholesterol biosynthetic process|oxidation-reduction process hsa00100 Steroid biosynthesis SCAF1 1757.035748 1705.126027 1808.945469 1.060886668 0.085270544 0.794791772 1 18.37026546 20.32826687 58506 SR-related CTD associated factor 1 "GO:0003723,GO:0005515,GO:0005634,GO:0006366,GO:0006397,GO:0008380,GO:0019904,GO:0099122" RNA binding|protein binding|nucleus|transcription by RNA polymerase II|mRNA processing|RNA splicing|protein domain specific binding|RNA polymerase II C-terminal domain binding SCAF11 2255.319991 2327.294035 2183.345947 0.938147872 -0.092112755 0.774435148 1 12.61038116 12.340008 9169 SR-related CTD associated factor 11 "GO:0000245,GO:0000375,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006397,GO:0008380,GO:0016604,GO:0046872" "spliceosomal complex assembly|RNA splicing, via transesterification reactions|RNA binding|protein binding|nucleoplasm|nucleolus|mRNA processing|RNA splicing|nuclear body|metal ion binding" SCAF4 906.5803424 885.0416044 928.1190804 1.048672826 0.068564644 0.851063193 1 7.16042093 7.832393484 57466 SR-related CTD associated factor 4 "GO:0003723,GO:0005634,GO:0005654,GO:0006397,GO:0008022,GO:1990269,GO:2000805" "RNA binding|nucleus|nucleoplasm|mRNA processing|protein C-terminus binding|RNA polymerase II C-terminal domain phosphoserine binding|negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled" SCAF8 1018.17824 1138.780597 897.5758835 0.788190356 -0.343383998 0.328504471 1 11.68224019 9.604464986 22828 SR-related CTD associated factor 8 "GO:0000993,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005849,GO:0006369,GO:0006378,GO:0016363,GO:0032786,GO:0043175,GO:1990269,GO:2000805" "RNA polymerase II complex binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|nuclear matrix|positive regulation of DNA-templated transcription, elongation|RNA polymerase core enzyme binding|RNA polymerase II C-terminal domain phosphoserine binding|negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled" SCAI 282.8827267 277.0829794 288.682474 1.041862891 0.059165432 0.90955967 1 1.152157259 1.252097822 286205 suppressor of cancer cell invasion "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0016021,GO:0030336,GO:0031965,GO:0035024,GO:0045892" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|integral component of membrane|negative regulation of cell migration|nuclear membrane|negative regulation of Rho protein signal transduction|negative regulation of transcription, DNA-templated" SCAMP1 1686.68386 1644.228669 1729.139051 1.051641468 0.072642936 0.825701493 1 13.36667441 14.66246546 9522 secretory carrier membrane protein 1 "GO:0005515,GO:0005802,GO:0005886,GO:0006892,GO:0015031,GO:0016021,GO:0030136,GO:0030672,GO:0032588,GO:0035579,GO:0042589,GO:0043312,GO:0055038" protein binding|trans-Golgi network|plasma membrane|post-Golgi vesicle-mediated transport|protein transport|integral component of membrane|clathrin-coated vesicle|synaptic vesicle membrane|trans-Golgi network membrane|specific granule membrane|zymogen granule membrane|neutrophil degranulation|recycling endosome membrane SCAMP2 2515.320434 2387.176438 2643.46443 1.107360306 0.147124713 0.645168743 1 44.97844684 51.95284514 10066 secretory carrier membrane protein 2 "GO:0005515,GO:0005794,GO:0006892,GO:0015031,GO:0016021,GO:0030133,GO:0032588,GO:0043231,GO:0055038,GO:0070062" protein binding|Golgi apparatus|post-Golgi vesicle-mediated transport|protein transport|integral component of membrane|transport vesicle|trans-Golgi network membrane|intracellular membrane-bounded organelle|recycling endosome membrane|extracellular exosome SCAMP3 1677.526246 1725.425146 1629.627345 0.944478727 -0.082409793 0.802566129 1 56.56096875 55.7217759 10067 secretory carrier membrane protein 3 "GO:0006892,GO:0015031,GO:0016021,GO:0031625,GO:0032588,GO:0043231,GO:0055038,GO:0070062" post-Golgi vesicle-mediated transport|protein transport|integral component of membrane|ubiquitin protein ligase binding|trans-Golgi network membrane|intracellular membrane-bounded organelle|recycling endosome membrane|extracellular exosome SCAMP4 1629.882698 1634.079109 1625.686287 0.994863883 -0.007428945 0.984040512 1 33.09090052 34.33904243 113178 secretory carrier membrane protein 4 "GO:0005515,GO:0015031,GO:0016021,GO:0032588,GO:0055038" protein binding|protein transport|integral component of membrane|trans-Golgi network membrane|recycling endosome membrane SCAMP5 481.2932566 470.9395693 491.6469439 1.043970343 0.062080729 0.885171729 1 6.069065601 6.60885043 192683 secretory carrier membrane protein 5 "GO:0000139,GO:0001819,GO:0005515,GO:0005886,GO:0006887,GO:0015031,GO:0016021,GO:0030672,GO:0032588,GO:0034976,GO:0044877,GO:0045806,GO:0045956,GO:0055038" Golgi membrane|positive regulation of cytokine production|protein binding|plasma membrane|exocytosis|protein transport|integral component of membrane|synaptic vesicle membrane|trans-Golgi network membrane|response to endoplasmic reticulum stress|protein-containing complex binding|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|recycling endosome membrane SCAND1 1067.745057 1260.575313 874.9148019 0.694059921 -0.526867873 0.130849884 1 49.52962959 35.85733233 51282 SCAN domain containing 1 "GO:0005515,GO:0005634,GO:0045893" "protein binding|nucleus|positive regulation of transcription, DNA-templated" SCAP 2109.424153 1985.253874 2233.594432 1.125092595 0.17004374 0.596977424 1 22.04475009 25.87077124 22937 SREBF chaperone "GO:0000139,GO:0001666,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006955,GO:0007568,GO:0008203,GO:0012507,GO:0016021,GO:0032868,GO:0032933,GO:0032934,GO:0032991,GO:0042304,GO:0044255,GO:0044877,GO:0045541,GO:0045542,GO:0051082,GO:0090110" Golgi membrane|response to hypoxia|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|immune response|aging|cholesterol metabolic process|ER to Golgi transport vesicle membrane|integral component of membrane|response to insulin|SREBP signaling pathway|sterol binding|protein-containing complex|regulation of fatty acid biosynthetic process|cellular lipid metabolic process|protein-containing complex binding|negative regulation of cholesterol biosynthetic process|positive regulation of cholesterol biosynthetic process|unfolded protein binding|COPII-coated vesicle cargo loading SCAPER 454.9692277 355.2345889 554.7038665 1.561514233 0.642945719 0.124998701 1 1.235501905 2.012358238 49855 S-phase cyclin A associated protein in the ER "GO:0003676,GO:0005515,GO:0005654,GO:0005783,GO:0005829,GO:0008270,GO:0016607" nucleic acid binding|protein binding|nucleoplasm|endoplasmic reticulum|cytosol|zinc ion binding|nuclear speck SCARA3 169.2818871 54.80762229 283.756152 5.177311843 2.372203218 7.74E-05 0.012957239 0.350392921 1.892237206 51435 scavenger receptor class A member 3 "GO:0000139,GO:0005044,GO:0005515,GO:0005581,GO:0005615,GO:0005783,GO:0005789,GO:0006897,GO:0006979,GO:0009650,GO:0016021,GO:0034138,GO:0062023" Golgi membrane|scavenger receptor activity|protein binding|collagen trimer|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|endocytosis|response to oxidative stress|UV protection|integral component of membrane|toll-like receptor 3 signaling pathway|collagen-containing extracellular matrix SCARA5 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.02588967 0.039322335 286133 scavenger receptor class A member 5 "GO:0005044,GO:0005887,GO:0006879,GO:0006897,GO:0009897,GO:0034605,GO:0034755,GO:0070207,GO:0070287" scavenger receptor activity|integral component of plasma membrane|cellular iron ion homeostasis|endocytosis|external side of plasma membrane|cellular response to heat|iron ion transmembrane transport|protein homotrimerization|ferritin receptor activity SCARB1 1439.368883 1811.696404 1067.041363 0.588973606 -0.763725113 0.022409367 0.651795186 20.37212068 12.51549418 949 scavenger receptor class B member 1 "GO:0001530,GO:0001540,GO:0001618,GO:0001786,GO:0001875,GO:0001935,GO:0005044,GO:0005215,GO:0005515,GO:0005545,GO:0005737,GO:0005764,GO:0005765,GO:0005886,GO:0005887,GO:0005901,GO:0006702,GO:0006707,GO:0006898,GO:0008035,GO:0008289,GO:0009986,GO:0010595,GO:0010867,GO:0010886,GO:0010899,GO:0015914,GO:0015920,GO:0030169,GO:0030666,GO:0031528,GO:0031663,GO:0032497,GO:0033344,GO:0034185,GO:0034186,GO:0034375,GO:0034381,GO:0034383,GO:0034384,GO:0035461,GO:0042060,GO:0042632,GO:0042802,GO:0043231,GO:0043534,GO:0043654,GO:0043691,GO:0044406,GO:0046718,GO:0050764,GO:0050892,GO:0051000,GO:0070062,GO:0070328,GO:0070506,GO:0070508" lipopolysaccharide binding|amyloid-beta binding|virus receptor activity|phosphatidylserine binding|lipopolysaccharide immune receptor activity|endothelial cell proliferation|scavenger receptor activity|transporter activity|protein binding|1-phosphatidylinositol binding|cytoplasm|lysosome|lysosomal membrane|plasma membrane|integral component of plasma membrane|caveola|androgen biosynthetic process|cholesterol catabolic process|receptor-mediated endocytosis|high-density lipoprotein particle binding|lipid binding|cell surface|positive regulation of endothelial cell migration|positive regulation of triglyceride biosynthetic process|positive regulation of cholesterol storage|regulation of phosphatidylcholine catabolic process|phospholipid transport|lipopolysaccharide transport|low-density lipoprotein particle binding|endocytic vesicle membrane|microvillus membrane|lipopolysaccharide-mediated signaling pathway|detection of lipopolysaccharide|cholesterol efflux|apolipoprotein binding|apolipoprotein A-I binding|high-density lipoprotein particle remodeling|plasma lipoprotein particle clearance|low-density lipoprotein particle clearance|high-density lipoprotein particle clearance|vitamin transmembrane transport|wound healing|cholesterol homeostasis|identical protein binding|intracellular membrane-bounded organelle|blood vessel endothelial cell migration|recognition of apoptotic cell|reverse cholesterol transport|adhesion of symbiont to host|viral entry into host cell|regulation of phagocytosis|intestinal absorption|positive regulation of nitric-oxide synthase activity|extracellular exosome|triglyceride homeostasis|high-density lipoprotein particle receptor activity|cholesterol import "hsa04145,hsa04913,hsa04925,hsa04927,hsa04934,hsa04975,hsa04976,hsa04977,hsa04979,hsa05160" Phagosome|Ovarian steroidogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Fat digestion and absorption|Bile secretion|Vitamin digestion and absorption|Cholesterol metabolism|Hepatitis C SCARB2 4580.589551 4890.057856 4271.121246 0.873429594 -0.195236681 0.541853386 1 52.7618618 48.06887349 950 scavenger receptor class B member 2 "GO:0000139,GO:0001618,GO:0001786,GO:0004888,GO:0005044,GO:0005515,GO:0005737,GO:0005765,GO:0005789,GO:0005886,GO:0005925,GO:0006622,GO:0006898,GO:0010008,GO:0010976,GO:0015485,GO:0015917,GO:0016020,GO:0016021,GO:0019899,GO:0030665,GO:0030666,GO:0031210,GO:0031902,GO:0038024,GO:0042803,GO:0043202,GO:0043471,GO:0046718,GO:0061024,GO:0070062,GO:1904978,GO:1905123,GO:1905671" Golgi membrane|virus receptor activity|phosphatidylserine binding|transmembrane signaling receptor activity|scavenger receptor activity|protein binding|cytoplasm|lysosomal membrane|endoplasmic reticulum membrane|plasma membrane|focal adhesion|protein targeting to lysosome|receptor-mediated endocytosis|endosome membrane|positive regulation of neuron projection development|cholesterol binding|aminophospholipid transport|membrane|integral component of membrane|enzyme binding|clathrin-coated vesicle membrane|endocytic vesicle membrane|phosphatidylcholine binding|late endosome membrane|cargo receptor activity|protein homodimerization activity|lysosomal lumen|regulation of cellular carbohydrate catabolic process|viral entry into host cell|membrane organization|extracellular exosome|regulation of endosome organization|regulation of glucosylceramidase activity|regulation of lysosome organization hsa04142 Lysosome SCARF1 46.16837239 57.8524902 34.48425458 0.596072087 -0.746441278 0.39458131 1 0.912211873 0.567166323 8578 scavenger receptor class F member 1 "GO:0004888,GO:0005044,GO:0005515,GO:0005886,GO:0006707,GO:0006898,GO:0007155,GO:0010976,GO:0016021,GO:0016322,GO:0016358,GO:0030169,GO:0030666,GO:0048680" transmembrane signaling receptor activity|scavenger receptor activity|protein binding|plasma membrane|cholesterol catabolic process|receptor-mediated endocytosis|cell adhesion|positive regulation of neuron projection development|integral component of membrane|neuron remodeling|dendrite development|low-density lipoprotein particle binding|endocytic vesicle membrane|positive regulation of axon regeneration SCARF2 303.7689961 256.78386 350.7541323 1.365950852 0.449905575 0.340262109 1 3.670673618 5.229940807 91179 scavenger receptor class F member 2 "GO:0005044,GO:0005515,GO:0005925,GO:0006897,GO:0007157,GO:0016021" scavenger receptor activity|protein binding|focal adhesion|endocytosis|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|integral component of membrane SCCPDH 1149.06599 993.641893 1304.490088 1.312837247 0.392688076 0.2543144 1 23.50511748 32.18764818 51097 saccharopine dehydrogenase (putative) "GO:0002576,GO:0005576,GO:0005634,GO:0005739,GO:0005811,GO:0005886,GO:0009247,GO:0016020,GO:0016491,GO:0030496,GO:0031093,GO:0055114" platelet degranulation|extracellular region|nucleus|mitochondrion|lipid droplet|plasma membrane|glycolipid biosynthetic process|membrane|oxidoreductase activity|midbody|platelet alpha granule lumen|oxidation-reduction process SCD 4761.893549 6170.932288 3352.85481 0.543330352 -0.880098454 0.006355922 0.31983627 59.58740717 33.77025845 6319 stearoyl-CoA desaturase "GO:0004768,GO:0005506,GO:0005515,GO:0005730,GO:0005783,GO:0005789,GO:0006636,GO:0016020,GO:0016021,GO:0016491,GO:0030176,GO:0032896,GO:0045540,GO:0046949,GO:0055114,GO:0070542,GO:0120162,GO:1903966" stearoyl-CoA 9-desaturase activity|iron ion binding|protein binding|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|membrane|integral component of membrane|oxidoreductase activity|integral component of endoplasmic reticulum membrane|palmitoyl-CoA 9-desaturase activity|regulation of cholesterol biosynthetic process|fatty-acyl-CoA biosynthetic process|oxidation-reduction process|response to fatty acid|positive regulation of cold-induced thermogenesis|monounsaturated fatty acid biosynthetic process "hsa01040,hsa03320,hsa04152" Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|AMPK signaling pathway SCD5 228.3868657 188.7818101 267.9919213 1.419585505 0.505469749 0.32840638 1 2.259780832 3.346137681 79966 stearoyl-CoA desaturase 5 "GO:0004768,GO:0005506,GO:0005789,GO:0006636,GO:0016021,GO:0016491,GO:0046949,GO:0055114,GO:1903966" stearoyl-CoA 9-desaturase activity|iron ion binding|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|integral component of membrane|oxidoreductase activity|fatty-acyl-CoA biosynthetic process|oxidation-reduction process|monounsaturated fatty acid biosynthetic process "hsa01040,hsa03320,hsa04152" Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|AMPK signaling pathway SCFD1 1115.921815 1219.977074 1011.866556 0.829414402 -0.269834996 0.435848711 1 24.22090748 20.95452945 23256 sec1 family domain containing 1 "GO:0000139,GO:0000902,GO:0001666,GO:0005515,GO:0005789,GO:0005798,GO:0005801,GO:0005829,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0006892,GO:0006904,GO:0009636,GO:0016192,GO:0019905,GO:0032580,GO:0044877,GO:0047485,GO:0048208,GO:0051223,GO:0060628,GO:1901998,GO:1902902" "Golgi membrane|cell morphogenesis|response to hypoxia|protein binding|endoplasmic reticulum membrane|Golgi-associated vesicle|cis-Golgi network|cytosol|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|post-Golgi vesicle-mediated transport|vesicle docking involved in exocytosis|response to toxic substance|vesicle-mediated transport|syntaxin binding|Golgi cisterna membrane|protein-containing complex binding|protein N-terminus binding|COPII vesicle coating|regulation of protein transport|regulation of ER to Golgi vesicle-mediated transport|toxin transport|negative regulation of autophagosome assembly" SCFD2 273.1164356 316.6662621 229.5666091 0.724948113 -0.464050355 0.341597677 1 1.464125346 1.107136356 152579 sec1 family domain containing 2 "GO:0003674,GO:0005575,GO:0005886,GO:0006886,GO:0006904,GO:0008150,GO:0016192,GO:0019905,GO:0030141" molecular_function|cellular_component|plasma membrane|intracellular protein transport|vesicle docking involved in exocytosis|biological_process|vesicle-mediated transport|syntaxin binding|secretory granule SCG2 5.552566274 9.134603715 1.970528833 0.215721327 -2.212759283 0.247208451 1 0.190072084 0.042768828 7857 secretogranin II "GO:0000165,GO:0001525,GO:0001937,GO:0001938,GO:0005125,GO:0005515,GO:0005615,GO:0005788,GO:0006954,GO:0009306,GO:0030141,GO:0035556,GO:0042056,GO:0043542,GO:0043687,GO:0044267,GO:0048245,GO:0050918,GO:0050930,GO:0098992,GO:2000352,GO:2001237" MAPK cascade|angiogenesis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|cytokine activity|protein binding|extracellular space|endoplasmic reticulum lumen|inflammatory response|protein secretion|secretory granule|intracellular signal transduction|chemoattractant activity|endothelial cell migration|post-translational protein modification|cellular protein metabolic process|eosinophil chemotaxis|positive chemotaxis|induction of positive chemotaxis|neuronal dense core vesicle|negative regulation of endothelial cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway SCG5 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.128724389 0.173788527 6447 secretogranin V "GO:0004857,GO:0005515,GO:0005525,GO:0005576,GO:0006886,GO:0007218,GO:0016486,GO:0030141,GO:0030234,GO:0043086,GO:0046883,GO:0051082" enzyme inhibitor activity|protein binding|GTP binding|extracellular region|intracellular protein transport|neuropeptide signaling pathway|peptide hormone processing|secretory granule|enzyme regulator activity|negative regulation of catalytic activity|regulation of hormone secretion|unfolded protein binding SCGB2B2 46.01991463 47.70293051 44.33689874 0.929437631 -0.105570037 0.929007754 1 0.357235716 0.346330751 284402 secretoglobin family 2B member 2 "GO:0005515,GO:0005576" protein binding|extracellular region SCLT1 214.518935 183.7070303 245.3308397 1.335446114 0.417321764 0.430110146 1 1.148655926 1.600045218 132320 sodium channel and clathrin linker 1 "GO:0005813,GO:0005814,GO:0005829,GO:0008022,GO:0017080,GO:0030276,GO:0045162,GO:0060271,GO:0071439,GO:0097539,GO:0097711" centrosome|centriole|cytosol|protein C-terminus binding|sodium channel regulator activity|clathrin binding|clustering of voltage-gated sodium channels|cilium assembly|clathrin complex|ciliary transition fiber|ciliary basal body-plasma membrane docking SCLY 256.6368861 301.4419226 211.8318496 0.702728565 -0.508960552 0.306451784 1 6.231416309 4.56762355 51540 selenocysteine lyase "GO:0001887,GO:0005515,GO:0005794,GO:0005829,GO:0006520,GO:0009000,GO:0016740" selenium compound metabolic process|protein binding|Golgi apparatus|cytosol|cellular amino acid metabolic process|selenocysteine lyase activity|transferase activity hsa00450 Selenocompound metabolism SCMH1 846.7694475 803.845127 889.6937681 1.106797489 0.146391276 0.688816839 1 10.5416675 12.17007932 22955 Scm polycomb group protein homolog 1 "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0007283,GO:0009952,GO:0010369,GO:0016458,GO:0042393,GO:0045892" "chromatin binding|protein binding|nucleus|nucleoplasm|chromatin remodeling|spermatogenesis|anterior/posterior pattern specification|chromocenter|gene silencing|histone binding|negative regulation of transcription, DNA-templated" SCML1 840.0925617 852.5630134 827.6221099 0.970745971 -0.042834281 0.909505121 1 4.71956596 4.778852062 6322 Scm polycomb group protein like 1 "GO:0003682,GO:0005634,GO:0042393,GO:0045892" "chromatin binding|nucleus|histone binding|negative regulation of transcription, DNA-templated" SCML2 198.0272613 133.9741878 262.0803348 1.956200213 0.968054035 0.074572816 1 1.543521379 3.149501944 10389 Scm polycomb group protein like 2 "GO:0003682,GO:0005515,GO:0005634,GO:0009653,GO:0031519,GO:0042393,GO:0045892" "chromatin binding|protein binding|nucleus|anatomical structure morphogenesis|PcG protein complex|histone binding|negative regulation of transcription, DNA-templated" SCN1A 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.034934339 0.015721412 6323 sodium voltage-gated channel alpha subunit 1 "GO:0001518,GO:0005244,GO:0005248,GO:0005654,GO:0005886,GO:0006814,GO:0016604,GO:0019228,GO:0030018,GO:0030424,GO:0034765,GO:0035725,GO:0050966,GO:0086002,GO:0086010" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|nucleoplasm|plasma membrane|sodium ion transport|nuclear body|neuronal action potential|Z disc|axon|regulation of ion transmembrane transport|sodium ion transmembrane transport|detection of mechanical stimulus involved in sensory perception of pain|cardiac muscle cell action potential involved in contraction|membrane depolarization during action potential hsa04728 Dopaminergic synapse SCN1B 211.6670622 190.8117221 232.5224023 1.218596006 0.285219916 0.593770454 1 4.441149163 5.645092204 6324 sodium voltage-gated channel beta subunit 1 "GO:0001518,GO:0005244,GO:0005248,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007155,GO:0007411,GO:0010765,GO:0010976,GO:0014704,GO:0017080,GO:0019227,GO:0019871,GO:0021966,GO:0030315,GO:0033268,GO:0035725,GO:0040011,GO:0043204,GO:0044325,GO:0046684,GO:0051899,GO:0060048,GO:0060307,GO:0060371,GO:0061337,GO:0086002,GO:0086006,GO:0086012,GO:0086047,GO:0086062,GO:0086091,GO:1905150,GO:2000649" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|cell adhesion|axon guidance|positive regulation of sodium ion transport|positive regulation of neuron projection development|intercalated disc|sodium channel regulator activity|neuronal action potential propagation|sodium channel inhibitor activity|corticospinal neuron axon guidance|T-tubule|node of Ranvier|sodium ion transmembrane transport|locomotion|perikaryon|ion channel binding|response to pyrethroid|membrane depolarization|cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane depolarization|cardiac conduction|cardiac muscle cell action potential involved in contraction|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during cardiac muscle cell action potential|membrane depolarization during Purkinje myocyte cell action potential|voltage-gated sodium channel activity involved in Purkinje myocyte action potential|regulation of heart rate by cardiac conduction|regulation of voltage-gated sodium channel activity|regulation of sodium ion transmembrane transporter activity hsa04261 Adrenergic signaling in cardiomyocytes SCN2A 35.69220563 15.22433953 56.16007174 3.688834688 1.883165137 0.050596004 1 0.072243895 0.277975343 6326 sodium voltage-gated channel alpha subunit 2 "GO:0001518,GO:0005244,GO:0005248,GO:0005886,GO:0005887,GO:0006814,GO:0007399,GO:0007613,GO:0008627,GO:0014704,GO:0016020,GO:0019228,GO:0030315,GO:0030424,GO:0031226,GO:0033268,GO:0033270,GO:0034706,GO:0034765,GO:0035725,GO:0042552,GO:0051402,GO:0071456,GO:0086010,GO:0098978,GO:0099056" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|plasma membrane|integral component of plasma membrane|sodium ion transport|nervous system development|memory|intrinsic apoptotic signaling pathway in response to osmotic stress|intercalated disc|membrane|neuronal action potential|T-tubule|axon|intrinsic component of plasma membrane|node of Ranvier|paranode region of axon|sodium channel complex|regulation of ion transmembrane transport|sodium ion transmembrane transport|myelination|neuron apoptotic process|cellular response to hypoxia|membrane depolarization during action potential|glutamatergic synapse|integral component of presynaptic membrane hsa04742 Taste transduction SCN3A 9.597544372 16.23929549 2.95579325 0.182014869 -2.457871781 0.104356556 1 0.073638018 0.01398057 6328 sodium voltage-gated channel alpha subunit 3 "GO:0001518,GO:0005244,GO:0005248,GO:0005737,GO:0006814,GO:0019228,GO:0030424,GO:0034765,GO:0035725,GO:0086010" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|cytoplasm|sodium ion transport|neuronal action potential|axon|regulation of ion transmembrane transport|sodium ion transmembrane transport|membrane depolarization during action potential hsa04742 Taste transduction SCN5A 18.33131214 7.104691779 29.5579325 4.160339874 2.056701392 0.082494374 1 0.041782115 0.181315596 6331 sodium voltage-gated channel alpha subunit 5 "GO:0001518,GO:0002027,GO:0003231,GO:0003360,GO:0005244,GO:0005248,GO:0005515,GO:0005516,GO:0005654,GO:0005730,GO:0005783,GO:0005886,GO:0005901,GO:0006814,GO:0009986,GO:0010765,GO:0014704,GO:0014894,GO:0016021,GO:0016328,GO:0017134,GO:0019228,GO:0019899,GO:0019901,GO:0019904,GO:0021537,GO:0021549,GO:0030018,GO:0030315,GO:0030506,GO:0031625,GO:0035725,GO:0042383,GO:0042475,GO:0044325,GO:0045760,GO:0048471,GO:0050679,GO:0050998,GO:0051899,GO:0060048,GO:0060307,GO:0060371,GO:0060372,GO:0060373,GO:0061337,GO:0071277,GO:0086002,GO:0086004,GO:0086005,GO:0086006,GO:0086010,GO:0086012,GO:0086014,GO:0086015,GO:0086016,GO:0086043,GO:0086045,GO:0086046,GO:0086047,GO:0086048,GO:0086060,GO:0086061,GO:0086062,GO:0086063,GO:0086067,GO:0086091,GO:0097110,GO:0098912,GO:1902305" voltage-gated sodium channel complex|regulation of heart rate|cardiac ventricle development|brainstem development|voltage-gated ion channel activity|voltage-gated sodium channel activity|protein binding|calmodulin binding|nucleoplasm|nucleolus|endoplasmic reticulum|plasma membrane|caveola|sodium ion transport|cell surface|positive regulation of sodium ion transport|intercalated disc|response to denervation involved in regulation of muscle adaptation|integral component of membrane|lateral plasma membrane|fibroblast growth factor binding|neuronal action potential|enzyme binding|protein kinase binding|protein domain specific binding|telencephalon development|cerebellum development|Z disc|T-tubule|ankyrin binding|ubiquitin protein ligase binding|sodium ion transmembrane transport|sarcolemma|odontogenesis of dentin-containing tooth|ion channel binding|positive regulation of action potential|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|nitric-oxide synthase binding|membrane depolarization|cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane depolarization|regulation of atrial cardiac muscle cell membrane repolarization|regulation of ventricular cardiac muscle cell membrane depolarization|cardiac conduction|cellular response to calcium ion|cardiac muscle cell action potential involved in contraction|regulation of cardiac muscle cell contraction|ventricular cardiac muscle cell action potential|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during action potential|membrane depolarization during cardiac muscle cell action potential|atrial cardiac muscle cell action potential|SA node cell action potential|AV node cell action potential|bundle of His cell action potential|membrane depolarization during AV node cell action potential|membrane depolarization during SA node cell action potential|membrane depolarization during Purkinje myocyte cell action potential|membrane depolarization during bundle of His cell action potential|voltage-gated sodium channel activity involved in AV node cell action potential|voltage-gated sodium channel activity involved in bundle of His cell action potential|voltage-gated sodium channel activity involved in Purkinje myocyte action potential|voltage-gated sodium channel activity involved in SA node cell action potential|AV node cell to bundle of His cell communication|regulation of heart rate by cardiac conduction|scaffold protein binding|membrane depolarization during atrial cardiac muscle cell action potential|regulation of sodium ion transmembrane transport hsa04261 Adrenergic signaling in cardiomyocytes SCN8A 9.986256149 9.134603715 10.83790858 1.186467297 0.246672336 0.934370347 1 0.039707789 0.049141387 6334 sodium voltage-gated channel alpha subunit 8 "GO:0001518,GO:0005244,GO:0005248,GO:0005515,GO:0005524,GO:0005886,GO:0006814,GO:0007399,GO:0007422,GO:0016021,GO:0019228,GO:0030018,GO:0030054,GO:0030424,GO:0031410,GO:0033268,GO:0034765,GO:0035725,GO:0042552,GO:0043194,GO:0086010" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|protein binding|ATP binding|plasma membrane|sodium ion transport|nervous system development|peripheral nervous system development|integral component of membrane|neuronal action potential|Z disc|cell junction|axon|cytoplasmic vesicle|node of Ranvier|regulation of ion transmembrane transport|sodium ion transmembrane transport|myelination|axon initial segment|membrane depolarization during action potential SCN9A 45.33428733 34.50850292 56.16007174 1.627427068 0.702592892 0.426853167 1 0.174965856 0.297009794 6335 sodium voltage-gated channel alpha subunit 9 "GO:0001518,GO:0005244,GO:0005248,GO:0005887,GO:0006814,GO:0006954,GO:0009636,GO:0009791,GO:0019228,GO:0019233,GO:0030424,GO:0031402,GO:0034765,GO:0035725,GO:0048266,GO:0086010" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|integral component of plasma membrane|sodium ion transport|inflammatory response|response to toxic substance|post-embryonic development|neuronal action potential|sensory perception of pain|axon|sodium ion binding|regulation of ion transmembrane transport|sodium ion transmembrane transport|behavioral response to pain|membrane depolarization during action potential hsa04742 Taste transduction SCNN1A 21.49494625 21.31407534 21.67581716 1.016971969 0.024279915 1 1 0.278936104 0.295889561 6337 sodium channel epithelial 1 subunit alpha "GO:0001669,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0015280,GO:0016324,GO:0031514,GO:0034220,GO:0034706,GO:0035725,GO:0050699,GO:0050891,GO:0050896,GO:0050909,GO:0055078,GO:0060170,GO:0070062,GO:0097228" acrosomal vesicle|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|ligand-gated sodium channel activity|apical plasma membrane|motile cilium|ion transmembrane transport|sodium channel complex|sodium ion transmembrane transport|WW domain binding|multicellular organismal water homeostasis|response to stimulus|sensory perception of taste|sodium ion homeostasis|ciliary membrane|extracellular exosome|sperm principal piece "hsa04742,hsa04960" Taste transduction|Aldosterone-regulated sodium reabsorption SCNN1D 140.3271882 163.4079109 117.2464656 0.717507891 -0.478933396 0.431376892 1 2.713453842 2.030790158 6339 sodium channel epithelial 1 subunit delta "GO:0005515,GO:0005886,GO:0005887,GO:0006814,GO:0015280,GO:0015629,GO:0016020,GO:0034220,GO:0034706,GO:0035725,GO:0050896,GO:0050909" protein binding|plasma membrane|integral component of plasma membrane|sodium ion transport|ligand-gated sodium channel activity|actin cytoskeleton|membrane|ion transmembrane transport|sodium channel complex|sodium ion transmembrane transport|response to stimulus|sensory perception of taste SCO1 1030.863952 995.671805 1066.056099 1.070690255 0.098541176 0.780654266 1 5.265455195 5.880519592 6341 synthesis of cytochrome C oxidase 1 "GO:0005515,GO:0005739,GO:0006878,GO:0016531,GO:0030016,GO:0031305,GO:0033617" protein binding|mitochondrion|cellular copper ion homeostasis|copper chaperone activity|myofibril|integral component of mitochondrial inner membrane|mitochondrial cytochrome c oxidase assembly SCO2 332.6452607 378.5785762 286.7119452 0.757338009 -0.400990759 0.382102134 1 14.13987414 11.16994995 9997 synthesis of cytochrome C oxidase 2 "GO:0001654,GO:0001701,GO:0003012,GO:0005507,GO:0005515,GO:0005739,GO:0005759,GO:0006878,GO:0014823,GO:0015035,GO:0016531,GO:0022904,GO:0030016,GO:0031305,GO:0033617,GO:0055114" eye development|in utero embryonic development|muscle system process|copper ion binding|protein binding|mitochondrion|mitochondrial matrix|cellular copper ion homeostasis|response to activity|protein disulfide oxidoreductase activity|copper chaperone activity|respiratory electron transport chain|myofibril|integral component of mitochondrial inner membrane|mitochondrial cytochrome c oxidase assembly|oxidation-reduction process hsa05230 Central carbon metabolism in cancer SCOC 809.2066741 660.7363354 957.6770129 1.44940873 0.535464489 0.144327591 1 6.084357173 9.198595113 60592 short coiled-coil protein "GO:0000139,GO:0005515,GO:0005654,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0016239,GO:0061635" Golgi membrane|protein binding|nucleoplasm|endosome|Golgi apparatus|trans-Golgi network|cytosol|positive regulation of macroautophagy|regulation of protein complex stability SCP2 1337.68994 1293.053904 1382.325976 1.069039715 0.09631545 0.776351638 1 15.64467716 17.44521696 6342 sterol carrier protein 2 "GO:0000062,GO:0003988,GO:0005102,GO:0005515,GO:0005654,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0006694,GO:0006699,GO:0008206,GO:0015485,GO:0015914,GO:0016020,GO:0032385,GO:0032934,GO:0032991,GO:0033540,GO:0033814,GO:0036042,GO:0036109,GO:0043231,GO:0050632,GO:0050633,GO:0070538,GO:1901373" fatty-acyl-CoA binding|acetyl-CoA C-acyltransferase activity|signaling receptor binding|protein binding|nucleoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|steroid biosynthetic process|bile acid biosynthetic process|bile acid metabolic process|cholesterol binding|phospholipid transport|membrane|positive regulation of intracellular cholesterol transport|sterol binding|protein-containing complex|fatty acid beta-oxidation using acyl-CoA oxidase|propanoyl-CoA C-acyltransferase activity|long-chain fatty acyl-CoA binding|alpha-linolenic acid metabolic process|intracellular membrane-bounded organelle|propionyl-CoA C2-trimethyltridecanoyltransferase activity|acetyl-CoA C-myristoyltransferase activity|oleic acid binding|lipid hydroperoxide transport "hsa00120,hsa01040,hsa03320,hsa04146" Primary bile acid biosynthesis|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|Peroxisome SCPEP1 1819.740085 2186.215156 1453.265014 0.664740161 -0.589137577 0.070091691 1 57.57882743 39.92368901 59342 serine carboxypeptidase 1 "GO:0004185,GO:0005829,GO:0006508,GO:0042573,GO:0045776,GO:0070062,GO:0097746" serine-type carboxypeptidase activity|cytosol|proteolysis|retinoic acid metabolic process|negative regulation of blood pressure|extracellular exosome|blood vessel diameter maintenance SCRIB 3411.869983 3260.03857 3563.701395 1.093147004 0.128487424 0.68667188 1 29.44702209 33.57653534 23513 scribble planar cell polarity protein "GO:0001768,GO:0001772,GO:0001843,GO:0001921,GO:0005515,GO:0005654,GO:0005886,GO:0005911,GO:0005912,GO:0008283,GO:0008328,GO:0009790,GO:0014069,GO:0016323,GO:0016477,GO:0030027,GO:0030054,GO:0030683,GO:0030859,GO:0031252,GO:0032729,GO:0034750,GO:0035089,GO:0039563,GO:0039564,GO:0042734,GO:0043065,GO:0043113,GO:0045197,GO:0045211,GO:0045296,GO:0045930,GO:0046007,GO:0050918,GO:0060561,GO:0060603,GO:0070062,GO:0071896,GO:0090630,GO:0097120,GO:0098609,GO:0098887,GO:0098968" "establishment of T cell polarity|immunological synapse|neural tube closure|positive regulation of receptor recycling|protein binding|nucleoplasm|plasma membrane|cell-cell junction|adherens junction|cell population proliferation|ionotropic glutamate receptor complex|embryo development|postsynaptic density|basolateral plasma membrane|cell migration|lamellipodium|cell junction|mitigation of host immune response by virus|polarized epithelial cell differentiation|cell leading edge|positive regulation of interferon-gamma production|Scrib-APC-beta-catenin complex|establishment of apical/basal cell polarity|suppression by virus of host STAT1 activity|suppression by virus of host STAT2 activity|presynaptic membrane|positive regulation of apoptotic process|receptor clustering|establishment or maintenance of epithelial cell apical/basal polarity|postsynaptic membrane|cadherin binding|negative regulation of mitotic cell cycle|negative regulation of activated T cell proliferation|positive chemotaxis|apoptotic process involved in morphogenesis|mammary gland duct morphogenesis|extracellular exosome|protein localization to adherens junction|activation of GTPase activity|receptor localization to synapse|cell-cell adhesion|neurotransmitter receptor transport, endosome to postsynaptic membrane|neurotransmitter receptor transport postsynaptic membrane to endosome" "hsa04390,hsa04530,hsa05165,hsa05203" Hippo signaling pathway|Tight junction|Human papillomavirus infection|Viral carcinogenesis SCRN1 7302.339209 7076.273012 7528.405407 1.063894142 0.08935461 0.785821081 1 58.79072579 65.24138458 9805 secernin 1 "GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0006508,GO:0006887,GO:0016805,GO:0031965,GO:0070004" molecular_function|protein binding|nucleus|cytoplasm|proteolysis|exocytosis|dipeptidase activity|nuclear membrane|cysteine-type exopeptidase activity SCRN2 328.8135667 318.6961741 338.9309593 1.063492401 0.088809725 0.852672009 1 7.366881298 8.172106032 90507 secernin 2 "GO:0003674,GO:0005515,GO:0006508,GO:0008150,GO:0016805,GO:0070004,GO:0070062" molecular_function|protein binding|proteolysis|biological_process|dipeptidase activity|cysteine-type exopeptidase activity|extracellular exosome SCRN3 226.9210933 223.290313 230.5518735 1.032520714 0.046170725 0.937787512 1 2.201025036 2.370498503 79634 secernin 3 "GO:0006508,GO:0016805,GO:0070004" proteolysis|dipeptidase activity|cysteine-type exopeptidase activity SCUBE2 8.941608628 5.074779842 12.80843742 2.523939523 1.335677342 0.379978469 1 0.035040177 0.092248893 57758 "signal peptide, CUB domain and EGF like domain containing 2" "GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007275,GO:0008289,GO:0009986" calcium ion binding|protein binding|extracellular region|extracellular space|signal transduction|multicellular organism development|lipid binding|cell surface SCUBE3 28.03277694 30.44867905 25.61687483 0.841313174 -0.249285159 0.834663052 1 0.192188208 0.168655441 222663 "signal peptide, CUB domain and EGF like domain containing 3" "GO:0005509,GO:0005515,GO:0005615,GO:0005886,GO:0007165,GO:0009986,GO:0022617,GO:0042802" calcium ion binding|protein binding|extracellular space|plasma membrane|signal transduction|cell surface|extracellular matrix disassembly|identical protein binding SCX 71.42622699 66.98709391 75.86536007 1.132536966 0.17955814 0.828169428 1 1.623282292 1.917619189 642658 scleraxis bHLH transcription factor "GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0001707,GO:0001894,GO:0001958,GO:0002062,GO:0003179,GO:0003188,GO:0003677,GO:0005515,GO:0005634,GO:0005667,GO:0006351,GO:0006357,GO:0008284,GO:0010628,GO:0030154,GO:0030199,GO:0030509,GO:0032502,GO:0032967,GO:0035914,GO:0035989,GO:0035990,GO:0035992,GO:0035993,GO:0043066,GO:0043425,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0048706,GO:0060008,GO:0060325,GO:0061035,GO:0061036,GO:0061056,GO:0070888,GO:0071260,GO:0071560,GO:2000543" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|mesoderm formation|tissue homeostasis|endochondral ossification|chondrocyte differentiation|heart valve morphogenesis|heart valve formation|DNA binding|protein binding|nucleus|transcription regulator complex|transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|positive regulation of gene expression|cell differentiation|collagen fibril organization|BMP signaling pathway|developmental process|positive regulation of collagen biosynthetic process|skeletal muscle cell differentiation|tendon development|tendon cell differentiation|tendon formation|deltoid tuberosity development|negative regulation of apoptotic process|bHLH transcription factor binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|embryonic skeletal system development|Sertoli cell differentiation|face morphogenesis|regulation of cartilage development|positive regulation of cartilage development|sclerotome development|E-box binding|cellular response to mechanical stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of gastrulation" SCYL1 2202.804062 2306.994916 2098.613207 0.909673963 -0.136578535 0.670574577 1 44.14097239 41.88356014 57410 SCY1 like pseudokinase 1 "GO:0003677,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0005793,GO:0005794,GO:0005801,GO:0005815,GO:0005829,GO:0006890,GO:0006954,GO:0016020,GO:0018108,GO:0021522,GO:0030126,GO:0034613,GO:0045296,GO:0048666" "DNA binding|protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|microtubule organizing center|cytosol|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|inflammatory response|membrane|peptidyl-tyrosine phosphorylation|spinal cord motor neuron differentiation|COPI vesicle coat|cellular protein localization|cadherin binding|neuron development" SCYL2 1384.495443 1226.06681 1542.924076 1.258433932 0.331629477 0.322375299 1 10.83888263 14.22757434 55681 SCY1 like pseudokinase 2 "GO:0002092,GO:0004672,GO:0005102,GO:0005515,GO:0005524,GO:0005794,GO:0006468,GO:0007420,GO:0008333,GO:0010008,GO:0021860,GO:0030136,GO:0090090,GO:2000286,GO:2000370" positive regulation of receptor internalization|protein kinase activity|signaling receptor binding|protein binding|ATP binding|Golgi apparatus|protein phosphorylation|brain development|endosome to lysosome transport|endosome membrane|pyramidal neuron development|clathrin-coated vesicle|negative regulation of canonical Wnt signaling pathway|receptor internalization involved in canonical Wnt signaling pathway|positive regulation of clathrin-dependent endocytosis SCYL3 212.622635 188.7818101 236.46346 1.252575446 0.324897503 0.541779664 1 1.415415648 1.849284869 57147 SCY1 like pseudokinase 3 "GO:0000139,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0006468,GO:0006954,GO:0016301,GO:0016477,GO:0021522,GO:0030027,GO:0034613,GO:0042802,GO:0048666" Golgi membrane|protein binding|ATP binding|cytoplasm|Golgi apparatus|protein phosphorylation|inflammatory response|kinase activity|cell migration|spinal cord motor neuron differentiation|lamellipodium|cellular protein localization|identical protein binding|neuron development SDAD1 845.1821873 863.7275291 826.6368455 0.957057426 -0.063322602 0.864601358 1 13.94032897 13.91640148 55153 SDA1 domain containing 1 "GO:0000055,GO:0003674,GO:0005654,GO:0005730,GO:0030036,GO:0042273" ribosomal large subunit export from nucleus|molecular_function|nucleoplasm|nucleolus|actin cytoskeleton organization|ribosomal large subunit biogenesis SDC1 1714.36306 1616.824858 1811.901262 1.120654011 0.164340932 0.615488776 1 22.11952329 25.85611333 6382 syndecan 1 "GO:0001523,GO:0001657,GO:0005515,GO:0005796,GO:0005886,GO:0005887,GO:0006024,GO:0006027,GO:0006954,GO:0008022,GO:0009636,GO:0009897,GO:0009986,GO:0016477,GO:0019221,GO:0032991,GO:0042060,GO:0042476,GO:0042542,GO:0042802,GO:0043202,GO:0048627,GO:0050900,GO:0051384,GO:0051591,GO:0051592,GO:0055002,GO:0060009,GO:0060070,GO:0070062,GO:1903543,GO:1903553" retinoid metabolic process|ureteric bud development|protein binding|Golgi lumen|plasma membrane|integral component of plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|inflammatory response|protein C-terminus binding|response to toxic substance|external side of plasma membrane|cell surface|cell migration|cytokine-mediated signaling pathway|protein-containing complex|wound healing|odontogenesis|response to hydrogen peroxide|identical protein binding|lysosomal lumen|myoblast development|leukocyte migration|response to glucocorticoid|response to cAMP|response to calcium ion|striated muscle cell development|Sertoli cell development|canonical Wnt signaling pathway|extracellular exosome|positive regulation of exosomal secretion|positive regulation of extracellular exosome assembly "hsa04512,hsa04514,hsa05144,hsa05205,hsa05418" ECM-receptor interaction|Cell adhesion molecules|Malaria|Proteoglycans in cancer|Fluid shear stress and atherosclerosis SDC2 99.34023773 89.31612522 109.3643502 1.224463667 0.292149966 0.675634746 1 1.156621492 1.477246912 6383 syndecan 2 "GO:0001523,GO:0005515,GO:0005788,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0008150,GO:0009986,GO:0016021,GO:0016477,GO:0030165,GO:0042802,GO:0043202,GO:0043687,GO:0044267,GO:0048013,GO:0048813,GO:0048814,GO:0050900,GO:0062023" retinoid metabolic process|protein binding|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|biological_process|cell surface|integral component of membrane|cell migration|PDZ domain binding|identical protein binding|lysosomal lumen|post-translational protein modification|cellular protein metabolic process|ephrin receptor signaling pathway|dendrite morphogenesis|regulation of dendrite morphogenesis|leukocyte migration|collagen-containing extracellular matrix "hsa04514,hsa05144,hsa05205,hsa05418" Cell adhesion molecules|Malaria|Proteoglycans in cancer|Fluid shear stress and atherosclerosis SDC3 1493.419617 1499.089965 1487.749269 0.992434946 -0.010955558 0.975882698 1 13.12875986 13.59069552 9672 syndecan 3 "GO:0001523,GO:0005515,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0009986,GO:0016020,GO:0016021,GO:0016477,GO:0042802,GO:0043202,GO:0044393,GO:0050900,GO:0062023" retinoid metabolic process|protein binding|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cell surface|membrane|integral component of membrane|cell migration|identical protein binding|lysosomal lumen|microspike|leukocyte migration|collagen-containing extracellular matrix hsa04514 Cell adhesion molecules SDC4 11670.69262 15104.57472 8236.810522 0.54531893 -0.874827858 0.01088315 0.44565019 293.438214 166.910314 6385 syndecan 4 "GO:0001523,GO:0001657,GO:0001843,GO:0001968,GO:0005080,GO:0005515,GO:0005796,GO:0005886,GO:0005887,GO:0005925,GO:0006024,GO:0006027,GO:0009986,GO:0010762,GO:0016477,GO:0042060,GO:0042130,GO:0042802,GO:0043034,GO:0043202,GO:0045121,GO:0045860,GO:0050900,GO:0051496,GO:0051894,GO:0060122,GO:0070053,GO:0070062,GO:1903543,GO:1903553" retinoid metabolic process|ureteric bud development|neural tube closure|fibronectin binding|protein kinase C binding|protein binding|Golgi lumen|plasma membrane|integral component of plasma membrane|focal adhesion|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cell surface|regulation of fibroblast migration|cell migration|wound healing|negative regulation of T cell proliferation|identical protein binding|costamere|lysosomal lumen|membrane raft|positive regulation of protein kinase activity|leukocyte migration|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|inner ear receptor cell stereocilium organization|thrombospondin receptor activity|extracellular exosome|positive regulation of exosomal secretion|positive regulation of extracellular exosome assembly "hsa04512,hsa04514,hsa05205,hsa05418" ECM-receptor interaction|Cell adhesion molecules|Proteoglycans in cancer|Fluid shear stress and atherosclerosis SDCBP 6626.626215 6717.993555 6535.258875 0.972799218 -0.039786026 0.903377271 1 77.71646274 78.85916386 6386 syndecan binding protein "GO:0002091,GO:0005109,GO:0005137,GO:0005515,GO:0005546,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0005895,GO:0005912,GO:0005925,GO:0006612,GO:0006930,GO:0007268,GO:0007346,GO:0008093,GO:0008284,GO:0010718,GO:0010862,GO:0016020,GO:0030036,GO:0030307,GO:0030335,GO:0030511,GO:0031965,GO:0032435,GO:0035556,GO:0035578,GO:0042327,GO:0042470,GO:0042802,GO:0043312,GO:0045121,GO:0045202,GO:0045545,GO:0046330,GO:0046982,GO:0047485,GO:0048013,GO:0070062,GO:0072562,GO:1903543,GO:1903553,GO:1903561" "negative regulation of receptor internalization|frizzled binding|interleukin-5 receptor binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|extracellular space|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|cytoskeleton|plasma membrane|interleukin-5 receptor complex|adherens junction|focal adhesion|protein targeting to membrane|substrate-dependent cell migration, cell extension|chemical synaptic transmission|regulation of mitotic cell cycle|cytoskeletal anchor activity|positive regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|membrane|actin cytoskeleton organization|positive regulation of cell growth|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|nuclear membrane|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|intracellular signal transduction|azurophil granule lumen|positive regulation of phosphorylation|melanosome|identical protein binding|neutrophil degranulation|membrane raft|synapse|syndecan binding|positive regulation of JNK cascade|protein heterodimerization activity|protein N-terminus binding|ephrin receptor signaling pathway|extracellular exosome|blood microparticle|positive regulation of exosomal secretion|positive regulation of extracellular exosome assembly|extracellular vesicle" SDCBP2 73.45613893 71.04691779 75.86536007 1.067820568 0.094669242 0.917883194 1 2.116632793 2.357543591 27111 syndecan binding protein 2 "GO:0005515,GO:0005546,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0007399,GO:0008022,GO:0008283,GO:0016607,GO:0035556,GO:0042802,GO:0042803,GO:0046907,GO:0046982,GO:0070062" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|nervous system development|protein C-terminus binding|cell population proliferation|nuclear speck|intracellular signal transduction|identical protein binding|protein homodimerization activity|intracellular transport|protein heterodimerization activity|extracellular exosome" SDCCAG8 363.9686028 330.8756457 397.0615599 1.200032595 0.263073593 0.557312361 1 1.503066122 1.881425641 10806 SHH signaling and ciliogenesis regulator SDCCAG8 "GO:0000086,GO:0001764,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005911,GO:0007098,GO:0010389,GO:0030010,GO:0031023,GO:0034451,GO:0035148,GO:0036064,GO:0097711,GO:0097733,GO:1902017" G2/M transition of mitotic cell cycle|neuron migration|protein binding|centrosome|centriole|cytosol|cell-cell junction|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|establishment of cell polarity|microtubule organizing center organization|centriolar satellite|tube formation|ciliary basal body|ciliary basal body-plasma membrane docking|photoreceptor cell cilium|regulation of cilium assembly SDE2 463.5733429 471.9545253 455.1921604 0.964483093 -0.052172146 0.905433019 1 5.995192313 6.031338007 163859 SDE2 telomere maintenance homolog "GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0006260,GO:0007049,GO:0016485,GO:0016567,GO:0016607,GO:0034644,GO:0051301,GO:0071156" damaged DNA binding|protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|DNA replication|cell cycle|protein processing|protein ubiquitination|nuclear speck|cellular response to UV|cell division|regulation of cell cycle arrest SDF2 732.8432387 727.7234293 737.963048 1.014070756 0.020158319 0.960968078 1 24.75260204 26.1821344 6388 stromal cell derived factor 2 "GO:0005783,GO:0016020,GO:0051085,GO:0051787,GO:0101031" endoplasmic reticulum|membrane|chaperone cofactor-dependent protein refolding|misfolded protein binding|chaperone complex SDF2L1 580.788633 671.9008511 489.676415 0.72879267 -0.456419646 0.246795959 1 41.24776701 31.35597923 23753 stromal cell derived factor 2 like 1 "GO:0004169,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0034663,GO:0035269,GO:0042981,GO:0051085,GO:0051087,GO:0051117,GO:0051787,GO:0071712,GO:0101031" dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endoplasmic reticulum chaperone complex|protein O-linked mannosylation|regulation of apoptotic process|chaperone cofactor-dependent protein refolding|chaperone binding|ATPase binding|misfolded protein binding|ER-associated misfolded protein catabolic process|chaperone complex SDF4 5707.894362 6383.058085 5032.73064 0.78845133 -0.342906392 0.289229066 1 83.47001651 68.64696158 51150 stromal cell derived factor 4 "GO:0005509,GO:0005515,GO:0005737,GO:0005770,GO:0005783,GO:0005794,GO:0005796,GO:0005886,GO:0009650,GO:0016020,GO:0017156,GO:0021549,GO:0032059,GO:0042802,GO:0045444,GO:0045471,GO:0070062,GO:0070625" calcium ion binding|protein binding|cytoplasm|late endosome|endoplasmic reticulum|Golgi apparatus|Golgi lumen|plasma membrane|UV protection|membrane|calcium-ion regulated exocytosis|cerebellum development|bleb|identical protein binding|fat cell differentiation|response to ethanol|extracellular exosome|zymogen granule exocytosis SDHA 4114.502075 3943.103937 4285.900212 1.086935643 0.120266521 0.706454032 1 47.41317758 53.75499457 6389 succinate dehydrogenase complex flavoprotein subunit A "GO:0000104,GO:0005515,GO:0005730,GO:0005739,GO:0005743,GO:0005749,GO:0006099,GO:0006105,GO:0006121,GO:0007399,GO:0008177,GO:0009055,GO:0022904,GO:0050660,GO:0055114" "succinate dehydrogenase activity|protein binding|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|tricarboxylic acid cycle|succinate metabolic process|mitochondrial electron transport, succinate to ubiquinone|nervous system development|succinate dehydrogenase (ubiquinone) activity|electron transfer activity|respiratory electron transport chain|flavin adenine dinucleotide binding|oxidation-reduction process" "hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases SDHAF1 164.3028629 152.2433953 176.3623306 1.158423525 0.212162806 0.718954233 1 6.853858566 8.281679825 644096 succinate dehydrogenase complex assembly factor 1 "GO:0005515,GO:0005739,GO:0005759,GO:0034553" protein binding|mitochondrion|mitochondrial matrix|mitochondrial respiratory chain complex II assembly SDHAF2 804.3112814 831.2489381 777.3736247 0.93518751 -0.096672433 0.794811063 1 35.49732398 34.62663125 54949 succinate dehydrogenase complex assembly factor 2 "GO:0005515,GO:0005730,GO:0005739,GO:0005759,GO:0005829,GO:0006099,GO:0006121,GO:0006470,GO:0010719,GO:0018293,GO:0034553,GO:0090090" "protein binding|nucleolus|mitochondrion|mitochondrial matrix|cytosol|tricarboxylic acid cycle|mitochondrial electron transport, succinate to ubiquinone|protein dephosphorylation|negative regulation of epithelial to mesenchymal transition|protein-FAD linkage|mitochondrial respiratory chain complex II assembly|negative regulation of canonical Wnt signaling pathway" SDHAF3 138.2500174 189.7967661 86.70326866 0.456821633 -1.130297123 0.064813247 1 10.09720235 4.811313452 57001 succinate dehydrogenase complex assembly factor 3 "GO:0005758,GO:0005759,GO:0006105,GO:0006111,GO:0034553" mitochondrial intermembrane space|mitochondrial matrix|succinate metabolic process|regulation of gluconeogenesis|mitochondrial respiratory chain complex II assembly SDHAF4 113.9559004 78.15160956 149.7601913 1.91627776 0.938306691 0.149505019 1 3.345818531 6.687699817 135154 succinate dehydrogenase complex assembly factor 4 "GO:0003674,GO:0005515,GO:0005575,GO:0005739,GO:0005749,GO:0005759,GO:0008177,GO:0034553,GO:0045087,GO:0045333" "molecular_function|protein binding|cellular_component|mitochondrion|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|mitochondrial matrix|succinate dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex II assembly|innate immune response|cellular respiration" SDHB 1445.901517 1517.359173 1374.443861 0.90581313 -0.142714644 0.669336205 1 75.71319131 71.53623731 6390 succinate dehydrogenase complex iron sulfur subunit B "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005749,GO:0005886,GO:0006099,GO:0006105,GO:0008177,GO:0009055,GO:0009060,GO:0022904,GO:0031966,GO:0046872,GO:0048039,GO:0051537,GO:0051538,GO:0051539" "protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|plasma membrane|tricarboxylic acid cycle|succinate metabolic process|succinate dehydrogenase (ubiquinone) activity|electron transfer activity|aerobic respiration|respiratory electron transport chain|mitochondrial membrane|metal ion binding|ubiquinone binding|2 iron, 2 sulfur cluster binding|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding" "hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases SDHC 1930.926753 1805.606668 2056.246837 1.138812164 0.187529809 0.562103716 1 69.91407334 83.04866067 6391 succinate dehydrogenase complex subunit C "GO:0000104,GO:0005515,GO:0005739,GO:0005743,GO:0005749,GO:0006099,GO:0006121,GO:0009055,GO:0009060,GO:0016021,GO:0020037,GO:0045273,GO:0046872,GO:0055114" "succinate dehydrogenase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|tricarboxylic acid cycle|mitochondrial electron transport, succinate to ubiquinone|electron transfer activity|aerobic respiration|integral component of membrane|heme binding|respiratory chain complex II|metal ion binding|oxidation-reduction process" "hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases SDHD 1321.38854 1290.009036 1352.768044 1.048650053 0.068533314 0.840826788 1 44.47543008 48.64818807 6392 succinate dehydrogenase complex subunit D "GO:0000104,GO:0005515,GO:0005739,GO:0005740,GO:0005743,GO:0005749,GO:0006099,GO:0006121,GO:0009055,GO:0016021,GO:0020037,GO:0046872,GO:0048039" "succinate dehydrogenase activity|protein binding|mitochondrion|mitochondrial envelope|mitochondrial inner membrane|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|tricarboxylic acid cycle|mitochondrial electron transport, succinate to ubiquinone|electron transfer activity|integral component of membrane|heme binding|metal ion binding|ubiquinone binding" "hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases SDK1 665.7655862 789.6357434 541.8954291 0.686260005 -0.543172818 0.155101572 1 3.851706129 2.757133299 221935 sidekick cell adhesion molecule 1 "GO:0005886,GO:0007156,GO:0007416,GO:0010842,GO:0016021,GO:0042802,GO:0045202,GO:0045216,GO:0048148,GO:0060998" plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|retina layer formation|integral component of membrane|identical protein binding|synapse|cell-cell junction organization|behavioral response to cocaine|regulation of dendritic spine development SDR16C5 27.42137853 22.3290313 32.51372575 1.456118956 0.542128219 0.609586596 1 0.368607126 0.559856226 195814 short chain dehydrogenase/reductase family 16C member 5 "GO:0000122,GO:0000785,GO:0003714,GO:0004745,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005811,GO:0005886,GO:0008134,GO:0016021,GO:0016616,GO:0017053,GO:0031065,GO:0033613,GO:0035067,GO:0042572,GO:0042574,GO:0043616,GO:0055114" "negative regulation of transcription by RNA polymerase II|chromatin|transcription corepressor activity|retinol dehydrogenase activity|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|plasma membrane|transcription factor binding|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|transcription repressor complex|positive regulation of histone deacetylation|activating transcription factor binding|negative regulation of histone acetylation|retinol metabolic process|retinal metabolic process|keratinocyte proliferation|oxidation-reduction process" hsa00830 Retinol metabolism SDR39U1 727.02617 666.8260712 787.2262688 1.180557124 0.239467851 0.523808845 1 23.45304728 28.88033424 56948 short chain dehydrogenase/reductase family 39U member 1 "GO:0005634,GO:0016491,GO:0055114" nucleus|oxidoreductase activity|oxidation-reduction process SDR42E1 27.42137853 22.3290313 32.51372575 1.456118956 0.542128219 0.609586596 1 0.095136423 0.144497258 93517 "short chain dehydrogenase/reductase family 42E, member 1" "GO:0003854,GO:0006694,GO:0016021,GO:0016616,GO:0055114" "3-beta-hydroxy-delta5-steroid dehydrogenase activity|steroid biosynthetic process|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|oxidation-reduction process" SDSL 74.69378154 88.30116925 61.08639383 0.691795979 -0.531581467 0.480896966 1 2.102558869 1.517197532 113675 serine dehydratase like "GO:0003674,GO:0003941,GO:0004794,GO:0005829,GO:0006567,GO:0008150,GO:0009097,GO:0019518,GO:0030170,GO:0042802" molecular_function|L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|cytosol|threonine catabolic process|biological_process|isoleucine biosynthetic process|L-threonine catabolic process to glycine|pyridoxal phosphate binding|identical protein binding "hsa00260,hsa00270,hsa00290" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Valine, leucine and isoleucine biosynthesis" SEC11A 3587.799064 3264.098394 3911.499734 1.19834002 0.26103732 0.412131355 1 131.9354099 164.9139385 23478 "SEC11 homolog A, signal peptidase complex subunit" "GO:0004252,GO:0005515,GO:0005787,GO:0005789,GO:0006465,GO:0008233,GO:0016021" serine-type endopeptidase activity|protein binding|signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|peptidase activity|integral component of membrane hsa03060 Protein export SEC11C 451.4950701 488.1938208 414.7963194 0.849654997 -0.235050942 0.577316694 1 25.67528014 22.7548374 90701 "SEC11 homolog C, signal peptidase complex subunit" "GO:0004252,GO:0005515,GO:0005787,GO:0005789,GO:0006465,GO:0008233,GO:0016021" serine-type endopeptidase activity|protein binding|signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|peptidase activity|integral component of membrane hsa03060 Protein export SEC13 3800.221531 4079.108037 3521.335025 0.863261035 -0.212131224 0.505434123 1 91.8188586 82.67799915 6396 "SEC13 homolog, nuclear pore and COPII coat complex component" "GO:0000139,GO:0000776,GO:0002474,GO:0005198,GO:0005515,GO:0005635,GO:0005654,GO:0005765,GO:0005789,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006886,GO:0012507,GO:0016032,GO:0019083,GO:0019886,GO:0030127,GO:0031080,GO:0032008,GO:0032527,GO:0042802,GO:0043231,GO:0043657,GO:0048208,GO:0060964,GO:0061700,GO:0070062,GO:0075733,GO:0090110,GO:0090114,GO:1900034,GO:1904263" Golgi membrane|kinetochore|antigen processing and presentation of peptide antigen via MHC class I|structural molecule activity|protein binding|nuclear envelope|nucleoplasm|lysosomal membrane|endoplasmic reticulum membrane|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|intracellular protein transport|ER to Golgi transport vesicle membrane|viral process|viral transcription|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|nuclear pore outer ring|positive regulation of TOR signaling|protein exit from endoplasmic reticulum|identical protein binding|intracellular membrane-bounded organelle|host cell|COPII vesicle coating|regulation of gene silencing by miRNA|GATOR2 complex|extracellular exosome|intracellular transport of virus|COPII-coated vesicle cargo loading|COPII-coated vesicle budding|regulation of cellular response to heat|positive regulation of TORC1 signaling "hsa03013,hsa04141,hsa04150,hsa05014" RNA transport|Protein processing in endoplasmic reticulum|mTOR signaling pathway|Amyotrophic lateral sclerosis SEC14L1 3697.603344 3361.534167 4033.672521 1.19994988 0.262974148 0.40882654 1 27.88238565 34.89867724 6397 SEC14 like lipid binding 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0015871,GO:0039536,GO:0039552,GO:0045087" protein binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|choline transport|negative regulation of RIG-I signaling pathway|RIG-I binding|innate immune response SEC14L2 609.6069983 587.6595057 631.554491 1.074694589 0.103926727 0.79287397 1 6.227847002 6.981342213 23541 SEC14 like lipid binding 2 "GO:0005543,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008431,GO:0045540,GO:0045893,GO:0070062" "phospholipid binding|nucleus|nucleoplasm|cytoplasm|cytosol|vitamin E binding|regulation of cholesterol biosynthetic process|positive regulation of transcription, DNA-templated|extracellular exosome" SEC16A 4477.111301 4652.558159 4301.664443 0.924580477 -0.113129195 0.723778509 1 23.18792142 22.36260891 9919 "SEC16 homolog A, endoplasmic reticulum export factor" "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0006914,GO:0007029,GO:0007030,GO:0012507,GO:0021762,GO:0031090,GO:0032527,GO:0034976,GO:0043000,GO:0048208,GO:0048471,GO:0050821,GO:0070863,GO:0070971,GO:0070973,GO:0072659" Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|autophagy|endoplasmic reticulum organization|Golgi organization|ER to Golgi transport vesicle membrane|substantia nigra development|organelle membrane|protein exit from endoplasmic reticulum|response to endoplasmic reticulum stress|Golgi to plasma membrane CFTR protein transport|COPII vesicle coating|perinuclear region of cytoplasm|protein stabilization|positive regulation of protein exit from endoplasmic reticulum|endoplasmic reticulum exit site|protein localization to endoplasmic reticulum exit site|protein localization to plasma membrane SEC22A 406.5522161 413.0870791 400.0173531 0.968360845 -0.046383348 0.920196595 1 5.97925215 6.039486558 26984 "SEC22 homolog A, vesicle trafficking protein" "GO:0005215,GO:0005515,GO:0005789,GO:0006888,GO:0015031,GO:0016021" transporter activity|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|integral component of membrane SEC22B 2524.453553 2607.421883 2441.485224 0.936359873 -0.094864984 0.766962036 1 14.61612838 14.27549161 9554 "SEC22 homolog B, vesicle trafficking protein" "GO:0000139,GO:0002479,GO:0005484,GO:0005515,GO:0005789,GO:0005793,GO:0006888,GO:0006890,GO:0008021,GO:0012507,GO:0015031,GO:0016021,GO:0019905,GO:0030133,GO:0030137,GO:0030670,GO:0031201,GO:0033116,GO:0042470,GO:0045732,GO:0048208,GO:0048280,GO:1902902,GO:1990668" "Golgi membrane|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|SNAP receptor activity|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|synaptic vesicle|ER to Golgi transport vesicle membrane|protein transport|integral component of membrane|syntaxin binding|transport vesicle|COPI-coated vesicle|phagocytic vesicle membrane|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|melanosome|positive regulation of protein catabolic process|COPII vesicle coating|vesicle fusion with Golgi apparatus|negative regulation of autophagosome assembly|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane" "hsa04130,hsa04145,hsa05134" SNARE interactions in vesicular transport|Phagosome|Legionellosis SEC22C 1982.119924 1937.550944 2026.688905 1.04600548 0.06489041 0.841802374 1 14.46067198 15.77750637 9117 "SEC22 homolog C, vesicle trafficking protein" "GO:0005515,GO:0005783,GO:0005789,GO:0006888,GO:0015031,GO:0016021" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|integral component of membrane SEC23A 4859.826897 5018.957264 4700.696531 0.936588276 -0.094513116 0.768579091 1 62.42447927 60.98451511 10484 "SEC23 homolog A, COPII coat complex component" "GO:0000139,GO:0002474,GO:0005096,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0019898,GO:0030127,GO:0043547,GO:0048208,GO:0048471,GO:0070971,GO:0072659,GO:0090110" Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|GTPase activator activity|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|extrinsic component of membrane|COPII vesicle coat|positive regulation of GTPase activity|COPII vesicle coating|perinuclear region of cytoplasm|endoplasmic reticulum exit site|protein localization to plasma membrane|COPII-coated vesicle cargo loading hsa04141 Protein processing in endoplasmic reticulum SEC23B 2574.607521 2668.319241 2480.895801 0.929759739 -0.10507014 0.742473516 1 38.97922016 37.80243819 10483 "SEC23 homolog B, COPII coat complex component" "GO:0000139,GO:0005096,GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0006886,GO:0008270,GO:0012505,GO:0030127,GO:0043547,GO:0048471,GO:0070971,GO:0090110" Golgi membrane|GTPase activator activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|intracellular protein transport|zinc ion binding|endomembrane system|COPII vesicle coat|positive regulation of GTPase activity|perinuclear region of cytoplasm|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading hsa04141 Protein processing in endoplasmic reticulum SEC23IP 1068.839685 1200.692911 936.9864601 0.780371444 -0.357767109 0.304667334 1 12.52798931 10.19761644 11196 SEC23 interacting protein "GO:0000139,GO:0003723,GO:0004620,GO:0005515,GO:0005737,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0006886,GO:0007030,GO:0012507,GO:0030134,GO:0043231,GO:0046872,GO:0048208" Golgi membrane|RNA binding|phospholipase activity|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|intracellular protein transport|Golgi organization|ER to Golgi transport vesicle membrane|COPII-coated ER to Golgi transport vesicle|intracellular membrane-bounded organelle|metal ion binding|COPII vesicle coating SEC24A 1949.979818 2299.890224 1600.069412 0.695715559 -0.52343051 0.10535552 1 14.84595034 10.77347105 10802 "SEC24 homolog A, COPII coat complex component" "GO:0000139,GO:0000149,GO:0002474,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0030127,GO:0048208,GO:0070971,GO:0090110" Golgi membrane|SNARE binding|antigen processing and presentation of peptide antigen via MHC class I|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|COPII vesicle coating|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading "hsa04141,hsa05130" Protein processing in endoplasmic reticulum|Pathogenic Escherichia coli infection SEC24B 1199.345405 1164.154496 1234.536314 1.060457455 0.084686742 0.80635875 1 11.08693462 12.26367594 10427 "SEC24 homolog B, COPII coat complex component" "GO:0000139,GO:0000149,GO:0001843,GO:0002474,GO:0003151,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0021747,GO:0030127,GO:0035909,GO:0048208,GO:0060088,GO:0060463,GO:0060982,GO:0061156,GO:0070971,GO:0090110,GO:0090178,GO:1901301" Golgi membrane|SNARE binding|neural tube closure|antigen processing and presentation of peptide antigen via MHC class I|outflow tract morphogenesis|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|cochlear nucleus development|COPII vesicle coat|aorta morphogenesis|COPII vesicle coating|auditory receptor cell stereocilium organization|lung lobe morphogenesis|coronary artery morphogenesis|pulmonary artery morphogenesis|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading|regulation of establishment of planar polarity involved in neural tube closure|regulation of cargo loading into COPII-coated vesicle "hsa04141,hsa05130" Protein processing in endoplasmic reticulum|Pathogenic Escherichia coli infection SEC24C 5932.760304 5994.329949 5871.190658 0.979457372 -0.02994539 0.926886066 1 63.03813646 64.40281271 9632 "SEC24 homolog C, COPII coat complex component" "GO:0000139,GO:0000149,GO:0002474,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0030127,GO:0048208,GO:0070971,GO:0090110" Golgi membrane|SNARE binding|antigen processing and presentation of peptide antigen via MHC class I|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|COPII vesicle coating|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading "hsa04141,hsa05130" Protein processing in endoplasmic reticulum|Pathogenic Escherichia coli infection SEC24D 1848.401828 2192.304892 1504.498764 0.686263471 -0.543165532 0.094330232 1 25.1945788 18.0349073 9871 "SEC24 homolog D, COPII coat complex component" "GO:0000139,GO:0000149,GO:0001701,GO:0002474,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0030127,GO:0043231,GO:0048208,GO:0070971,GO:0090110" Golgi membrane|SNARE binding|in utero embryonic development|antigen processing and presentation of peptide antigen via MHC class I|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|intracellular membrane-bounded organelle|COPII vesicle coating|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading "hsa04141,hsa05130" Protein processing in endoplasmic reticulum|Pathogenic Escherichia coli infection SEC31A 3249.013595 3678.200429 2819.82676 0.766632165 -0.383393565 0.228272748 1 39.58518399 31.65451286 22872 "SEC31 homolog A, COPII coat complex component" "GO:0000139,GO:0002474,GO:0005198,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0007029,GO:0012507,GO:0019886,GO:0030120,GO:0030127,GO:0030134,GO:0036498,GO:0043231,GO:0048208,GO:0048306,GO:0048471,GO:0051592,GO:0070971,GO:0090110" Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|structural molecule activity|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|vesicle coat|COPII vesicle coat|COPII-coated ER to Golgi transport vesicle|IRE1-mediated unfolded protein response|intracellular membrane-bounded organelle|COPII vesicle coating|calcium-dependent protein binding|perinuclear region of cytoplasm|response to calcium ion|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading hsa04141 Protein processing in endoplasmic reticulum SEC31B 209.2484385 193.85659 224.640287 1.158796237 0.212626905 0.694377998 1 2.118720845 2.560924326 25956 "SEC31 homolog B, COPII coat complex component" "GO:0000139,GO:0005198,GO:0005789,GO:0006886,GO:0007029,GO:0030120,GO:0030127,GO:0070971,GO:0090110" Golgi membrane|structural molecule activity|endoplasmic reticulum membrane|intracellular protein transport|endoplasmic reticulum organization|vesicle coat|COPII vesicle coat|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading hsa04141 Protein processing in endoplasmic reticulum SEC61A1 6355.150979 6412.491808 6297.810151 0.982115898 -0.02603481 0.936720636 1 91.02300677 93.2459222 29927 SEC61 translocon subunit alpha 1 "GO:0005048,GO:0005262,GO:0005515,GO:0005784,GO:0005789,GO:0005829,GO:0006613,GO:0006614,GO:0006616,GO:0006620,GO:0007029,GO:0008320,GO:0016020,GO:0030176,GO:0031204,GO:0039019,GO:0043022,GO:0045047,GO:0070588" "signal sequence binding|calcium channel activity|protein binding|Sec61 translocon complex|endoplasmic reticulum membrane|cytosol|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane, translocation|posttranslational protein targeting to endoplasmic reticulum membrane|endoplasmic reticulum organization|protein transmembrane transporter activity|membrane|integral component of endoplasmic reticulum membrane|posttranslational protein targeting to membrane, translocation|pronephric nephron development|ribosome binding|protein targeting to ER|calcium ion transmembrane transport" "hsa03060,hsa04141,hsa04145,hsa05110" Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC61A2 236.1717416 283.1727152 189.170768 0.668040238 -0.581993092 0.254829104 1 4.437406884 3.09205923 55176 SEC61 translocon subunit alpha 2 "GO:0003674,GO:0005048,GO:0005784,GO:0005829,GO:0006616,GO:0008150,GO:0008320,GO:0016021,GO:0031204,GO:0043022" "molecular_function|signal sequence binding|Sec61 translocon complex|cytosol|SRP-dependent cotranslational protein targeting to membrane, translocation|biological_process|protein transmembrane transporter activity|integral component of membrane|posttranslational protein targeting to membrane, translocation|ribosome binding" "hsa03060,hsa04141,hsa04145,hsa05110" Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC61B 1212.362921 1346.84657 1077.879272 0.800298487 -0.321389914 0.346836966 1 120.945084 100.9615817 10952 SEC61 translocon subunit beta "GO:0003723,GO:0005515,GO:0005783,GO:0005784,GO:0005789,GO:0005829,GO:0006616,GO:0016020,GO:0016021,GO:0030433,GO:0030970,GO:0031204,GO:0031205,GO:0044322,GO:0048408,GO:0050790" "RNA binding|protein binding|endoplasmic reticulum|Sec61 translocon complex|endoplasmic reticulum membrane|cytosol|SRP-dependent cotranslational protein targeting to membrane, translocation|membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|posttranslational protein targeting to membrane, translocation|endoplasmic reticulum Sec complex|endoplasmic reticulum quality control compartment|epidermal growth factor binding|regulation of catalytic activity" "hsa03060,hsa04141,hsa04145,hsa05110" Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC61G 1120.976306 1296.098772 945.8538399 0.729769876 -0.454486495 0.188827143 1 154.4537186 117.5710051 23480 SEC61 translocon subunit gamma "GO:0005515,GO:0005789,GO:0005829,GO:0008320,GO:0015450,GO:0016020,GO:0016021,GO:0031204,GO:0045047,GO:0071261" "protein binding|endoplasmic reticulum membrane|cytosol|protein transmembrane transporter activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|membrane|integral component of membrane|posttranslational protein targeting to membrane, translocation|protein targeting to ER|Ssh1 translocon complex" "hsa03060,hsa04141,hsa04145,hsa05110" Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC62 2259.209831 2222.753571 2295.666091 1.032802791 0.046564804 0.885579212 1 15.43386714 16.62677769 7095 "SEC62 homolog, preprotein translocation factor" "GO:0005783,GO:0005789,GO:0005791,GO:0005829,GO:0006613,GO:0006620,GO:0016020,GO:0016021,GO:0030176,GO:0031204,GO:0038023" "endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|cytosol|cotranslational protein targeting to membrane|posttranslational protein targeting to endoplasmic reticulum membrane|membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|posttranslational protein targeting to membrane, translocation|signaling receptor activity" "hsa03060,hsa04141" Protein export|Protein processing in endoplasmic reticulum SEC63 1569.467086 1646.258581 1492.675591 0.906707858 -0.141290307 0.66922481 1 13.16759151 12.45344923 11231 "SEC63 homolog, protein translocation regulator" "GO:0001889,GO:0003723,GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0006612,GO:0006614,GO:0006620,GO:0006807,GO:0008320,GO:0010259,GO:0016020,GO:0016021,GO:0031204,GO:0031207,GO:0038023" "liver development|RNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|posttranslational protein targeting to endoplasmic reticulum membrane|nitrogen compound metabolic process|protein transmembrane transporter activity|multicellular organism aging|membrane|integral component of membrane|posttranslational protein targeting to membrane, translocation|Sec62/Sec63 complex|signaling receptor activity" "hsa03060,hsa04141" Protein export|Protein processing in endoplasmic reticulum SECISBP2 1038.773037 1031.195264 1046.35081 1.014697068 0.021049083 0.954995975 1 10.54226933 11.15800219 79048 SECIS binding protein 2 "GO:0001514,GO:0003723,GO:0003730,GO:0005515,GO:0005654,GO:0005739,GO:0021756,GO:0035368,GO:0043021,GO:0048666,GO:1990904,GO:2000623" "selenocysteine incorporation|RNA binding|mRNA 3'-UTR binding|protein binding|nucleoplasm|mitochondrion|striatum development|selenocysteine insertion sequence binding|ribonucleoprotein complex binding|neuron development|ribonucleoprotein complex|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" SECISBP2L 1274.000092 1182.423703 1365.576481 1.154896064 0.207763021 0.54061133 1 8.483579717 10.21969598 9728 SECIS binding protein 2 like "GO:0001514,GO:0003723,GO:0003730,GO:0005515,GO:0035368,GO:0043021,GO:1990904" selenocysteine incorporation|RNA binding|mRNA 3'-UTR binding|protein binding|selenocysteine insertion sequence binding|ribonucleoprotein complex binding|ribonucleoprotein complex SECTM1 343.1417164 355.2345889 331.048844 0.931916132 -0.10172797 0.827984648 1 7.167879975 6.967604385 6398 secreted and transmembrane 1 "GO:0005125,GO:0005515,GO:0005615,GO:0005794,GO:0005886,GO:0006955,GO:0007165,GO:0007498,GO:0016021,GO:0043123,GO:0070062" cytokine activity|protein binding|extracellular space|Golgi apparatus|plasma membrane|immune response|signal transduction|mesoderm development|integral component of membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|extracellular exosome SEH1L 1149.73801 1174.304055 1125.171964 0.958160673 -0.061660495 0.860110614 1 14.47416834 14.46598101 81929 SEH1 like nucleoporin "GO:0000776,GO:0000777,GO:0005198,GO:0005515,GO:0005635,GO:0005765,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006999,GO:0007080,GO:0016032,GO:0016925,GO:0019083,GO:0031080,GO:0032008,GO:0034198,GO:0034629,GO:0035859,GO:0043657,GO:0050830,GO:0051301,GO:0051315,GO:0060964,GO:0061700,GO:0075733,GO:1900034,GO:1904263" kinetochore|condensed chromosome kinetochore|structural molecule activity|protein binding|nuclear envelope|lysosomal membrane|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nuclear pore organization|mitotic metaphase plate congression|viral process|protein sumoylation|viral transcription|nuclear pore outer ring|positive regulation of TOR signaling|cellular response to amino acid starvation|cellular protein-containing complex localization|Seh1-associated complex|host cell|defense response to Gram-positive bacterium|cell division|attachment of mitotic spindle microtubules to kinetochore|regulation of gene silencing by miRNA|GATOR2 complex|intracellular transport of virus|regulation of cellular response to heat|positive regulation of TORC1 signaling "hsa03013,hsa04150,hsa05014" RNA transport|mTOR signaling pathway|Amyotrophic lateral sclerosis SEL1L 3639.239171 3480.284016 3798.194326 1.091346082 0.126108675 0.692302378 1 20.56757383 23.41323846 6400 SEL1L adaptor subunit of ERAD E3 ubiquitin ligase "GO:0000836,GO:0000839,GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0006641,GO:0007219,GO:0009306,GO:0016021,GO:0016567,GO:0030433,GO:0030970,GO:0036503,GO:0036513,GO:0044322,GO:0050821,GO:0055085,GO:1904380" "Hrd1p ubiquitin ligase complex|Hrd1p ubiquitin ligase ERAD-L complex|ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|triglyceride metabolic process|Notch signaling pathway|protein secretion|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|ERAD pathway|Derlin-1 retrotranslocation complex|endoplasmic reticulum quality control compartment|protein stabilization|transmembrane transport|endoplasmic reticulum mannose trimming" hsa04141 Protein processing in endoplasmic reticulum SEL1L3 624.3090141 616.0782728 632.5397554 1.026719791 0.0380425 0.925992697 1 4.281898055 4.585684658 23231 SEL1L family member 3 "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane SELENOF 2514.350015 2388.191394 2640.508636 1.105652019 0.144897399 0.650199938 1 78.43934439 90.46245054 9403 selenoprotein F "GO:0005515,GO:0005788,GO:0016491,GO:0051084,GO:0055114" protein binding|endoplasmic reticulum lumen|oxidoreductase activity|'de novo' posttranslational protein folding|oxidation-reduction process SELENOH 1531.773422 1460.521638 1603.025206 1.097570322 0.134313378 0.685653088 1 63.11456363 72.25665772 280636 selenoprotein H "GO:0003723,GO:0005794" RNA binding|Golgi apparatus SELENOI 1353.166658 1340.756834 1365.576481 1.018511669 0.02646251 0.939515116 1 8.418621838 8.943817741 85465 selenoprotein I "GO:0004307,GO:0005789,GO:0005794,GO:0006646,GO:0016021,GO:0046872" ethanolaminephosphotransferase activity|endoplasmic reticulum membrane|Golgi apparatus|phosphatidylethanolamine biosynthetic process|integral component of membrane|metal ion binding "hsa00440,hsa00564,hsa00565" Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Ether lipid metabolism SELENOK 461.7661176 483.1190409 440.4131942 0.911603884 -0.133521023 0.752466734 1 16.34487313 15.54188355 58515 selenoprotein K "GO:0002230,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006816,GO:0006979,GO:0010742,GO:0016021,GO:0018345,GO:0032469,GO:0032755,GO:0032760,GO:0042102,GO:0042802,GO:0045728,GO:0050848,GO:0051223,GO:0070059,GO:0071639,GO:2000406" positive regulation of defense response to virus by host|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|calcium ion transport|response to oxidative stress|macrophage derived foam cell differentiation|integral component of membrane|protein palmitoylation|endoplasmic reticulum calcium ion homeostasis|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of T cell proliferation|identical protein binding|respiratory burst after phagocytosis|regulation of calcium-mediated signaling|regulation of protein transport|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of monocyte chemotactic protein-1 production|positive regulation of T cell migration SELENOM 48.8420959 38.5683268 59.11586499 1.532756796 0.616128801 0.4772534 1 2.814624916 4.499970926 140606 selenoprotein M "GO:0005515,GO:0005788,GO:0005794,GO:0010269,GO:0016491,GO:0035264,GO:0035934,GO:0042445,GO:0048471,GO:0055114,GO:0060612" protein binding|endoplasmic reticulum lumen|Golgi apparatus|response to selenium ion|oxidoreductase activity|multicellular organism growth|corticosterone secretion|hormone metabolic process|perinuclear region of cytoplasm|oxidation-reduction process|adipose tissue development SELENON 5181.45783 4812.921202 5549.994458 1.153144676 0.205573528 0.522859731 1 56.5038201 67.96378203 57190 selenoprotein N "GO:0005509,GO:0005515,GO:0005789,GO:0016491,GO:0048741,GO:0055074,GO:0055114,GO:0060314,GO:1902884" calcium ion binding|protein binding|endoplasmic reticulum membrane|oxidoreductase activity|skeletal muscle fiber development|calcium ion homeostasis|oxidation-reduction process|regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of response to oxidative stress SELENOO 680.9711206 684.0803227 677.8619186 0.990909833 -0.013174308 0.976630544 1 15.1757578 15.6855754 83642 selenoprotein O "GO:0005524,GO:0005694,GO:0005739,GO:0018117,GO:0046872,GO:0070733" ATP binding|chromosome|mitochondrion|protein adenylylation|metal ion binding|protein adenylyltransferase activity SELENOS 1533.806056 1431.087915 1636.524196 1.143552523 0.193522629 0.558937229 1 35.26985613 42.07031213 55829 selenoprotein S "GO:0002865,GO:0005515,GO:0005783,GO:0005789,GO:0005881,GO:0005886,GO:0006111,GO:0006983,GO:0009749,GO:0016209,GO:0016567,GO:0019899,GO:0030176,GO:0030433,GO:0030968,GO:0030970,GO:0032715,GO:0032720,GO:0032869,GO:0034361,GO:0034362,GO:0034599,GO:0036502,GO:0036513,GO:0038023,GO:0045184,GO:0045454,GO:0045719,GO:0046325,GO:0050728,GO:0051117,GO:0051771,GO:0051775,GO:0071222,GO:0080164,GO:0098869,GO:1902236,GO:1990381,GO:2000110" "negative regulation of acute inflammatory response to antigenic stimulus|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytoplasmic microtubule|plasma membrane|regulation of gluconeogenesis|ER overload response|response to glucose|antioxidant activity|protein ubiquitination|enzyme binding|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|cellular response to insulin stimulus|very-low-density lipoprotein particle|low-density lipoprotein particle|cellular response to oxidative stress|Derlin-1-VIMP complex|Derlin-1 retrotranslocation complex|signaling receptor activity|establishment of protein localization|cell redox homeostasis|negative regulation of glycogen biosynthetic process|negative regulation of glucose import|negative regulation of inflammatory response|ATPase binding|negative regulation of nitric-oxide synthase biosynthetic process|response to redox state|cellular response to lipopolysaccharide|regulation of nitric oxide metabolic process|cellular oxidant detoxification|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|ubiquitin-specific protease binding|negative regulation of macrophage apoptotic process" hsa04141 Protein processing in endoplasmic reticulum SELENOT 1200.263121 1260.575313 1139.95093 0.904310055 -0.14511059 0.672627998 1 18.57541244 17.52151903 51714 selenoprotein T "GO:0001514,GO:0004791,GO:0005783,GO:0005789,GO:0007204,GO:0008430,GO:0009749,GO:0016021,GO:0031016,GO:0035773,GO:0042593,GO:0045454,GO:0055114,GO:0060124,GO:0098869" selenocysteine incorporation|thioredoxin-disulfide reductase activity|endoplasmic reticulum|endoplasmic reticulum membrane|positive regulation of cytosolic calcium ion concentration|selenium binding|response to glucose|integral component of membrane|pancreas development|insulin secretion involved in cellular response to glucose stimulus|glucose homeostasis|cell redox homeostasis|oxidation-reduction process|positive regulation of growth hormone secretion|cellular oxidant detoxification SELENOW 795.348146 723.6636055 867.0326866 1.198115644 0.260767166 0.479113996 1 48.3522542 60.42705021 6415 selenoprotein W "GO:0005829,GO:0010269,GO:0016209,GO:0098869" cytosol|response to selenium ion|antioxidant activity|cellular oxidant detoxification SELL 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.065399414 0 6402 selectin L "GO:0002020,GO:0005509,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0008201,GO:0016339,GO:0030246,GO:0030667,GO:0043208,GO:0043312,GO:0050776,GO:0050900,GO:0050901,GO:0070492" protease binding|calcium ion binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|heparin binding|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|carbohydrate binding|secretory granule membrane|glycosphingolipid binding|neutrophil degranulation|regulation of immune response|leukocyte migration|leukocyte tethering or rolling|oligosaccharide binding hsa04514 Cell adhesion molecules SELPLG 10.06048503 14.20938356 5.911586499 0.416033987 -1.265226703 0.381088004 1 0.257387393 0.111694557 6404 selectin P ligand "GO:0001618,GO:0001931,GO:0005102,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0016020,GO:0016021,GO:0030097,GO:0044853,GO:0046718,GO:0050900,GO:0050901,GO:0050902,GO:0071354" virus receptor activity|uropod|signaling receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|membrane|integral component of membrane|hemopoiesis|plasma membrane raft|viral entry into host cell|leukocyte migration|leukocyte tethering or rolling|leukocyte adhesive activation|cellular response to interleukin-6 "hsa04514,hsa05150" Cell adhesion molecules|Staphylococcus aureus infection SEM1 1400.621169 1553.897588 1247.344751 0.802720051 -0.317031159 0.343369547 1 47.32377089 39.62409757 7979 SEM1 26S proteasome complex subunit "hsa03050,hsa03440,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Homologous recombination|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection SEMA3A 499.4961539 772.3814919 226.6108158 0.293392343 -1.769096874 2.55E-05 0.00549578 4.262191956 1.304360716 10371 semaphorin 3A "GO:0001755,GO:0001764,GO:0002027,GO:0005576,GO:0005615,GO:0005887,GO:0006915,GO:0007411,GO:0007413,GO:0008045,GO:0010633,GO:0010977,GO:0021612,GO:0021637,GO:0021675,GO:0021772,GO:0021785,GO:0021828,GO:0030215,GO:0030335,GO:0030424,GO:0030425,GO:0036486,GO:0038191,GO:0045499,GO:0046330,GO:0048485,GO:0048841,GO:0048843,GO:0048846,GO:0048880,GO:0050919,GO:0060385,GO:0060666,GO:0061549,GO:0061551,GO:0071526,GO:0097490,GO:0097491,GO:0150020,GO:1901166,GO:1902285,GO:1902287,GO:1903045,GO:1903375,GO:2000020,GO:2001224" neural crest cell migration|neuron migration|regulation of heart rate|extracellular region|extracellular space|integral component of plasma membrane|apoptotic process|axon guidance|axonal fasciculation|motor neuron axon guidance|negative regulation of epithelial cell migration|negative regulation of neuron projection development|facial nerve structural organization|trigeminal nerve structural organization|nerve development|olfactory bulb development|branchiomotor neuron axon guidance|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|semaphorin receptor binding|positive regulation of cell migration|axon|dendrite|ventral trunk neural crest cell migration|neuropilin binding|chemorepellent activity|positive regulation of JNK cascade|sympathetic nervous system development|regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|axon extension involved in axon guidance|sensory system development|negative chemotaxis|axonogenesis involved in innervation|dichotomous subdivision of terminal units involved in salivary gland branching|sympathetic ganglion development|trigeminal ganglion development|semaphorin-plexin signaling pathway|sympathetic neuron projection extension|sympathetic neuron projection guidance|basal dendrite arborization|neural crest cell migration involved in autonomic nervous system development|semaphorin-plexin signaling pathway involved in neuron projection guidance|semaphorin-plexin signaling pathway involved in axon guidance|neural crest cell migration involved in sympathetic nervous system development|facioacoustic ganglion development|positive regulation of male gonad development|positive regulation of neuron migration hsa04360 Axon guidance SEMA3B 57.31804226 79.16656553 35.469519 0.448036602 -1.158311499 0.155997367 1 1.156811097 0.540619704 7869 semaphorin 3B "GO:0001755,GO:0005615,GO:0005783,GO:0005887,GO:0007267,GO:0007411,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0061643,GO:0062023,GO:0071526" neural crest cell migration|extracellular space|endoplasmic reticulum|integral component of plasma membrane|cell-cell signaling|axon guidance|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|chemorepulsion of axon|collagen-containing extracellular matrix|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA3C 5813.088541 7916.656553 3709.520528 0.468571613 -1.09365854 0.000830989 0.080956814 78.81869985 38.52309492 10512 semaphorin 3C "GO:0001755,GO:0001756,GO:0001974,GO:0003148,GO:0003215,GO:0003350,GO:0005615,GO:0005887,GO:0006955,GO:0007411,GO:0009791,GO:0021915,GO:0030215,GO:0030335,GO:0042493,GO:0045499,GO:0048843,GO:0050919,GO:0060174,GO:0060666,GO:0070062,GO:0071526,GO:0140074,GO:1905312" neural crest cell migration|somitogenesis|blood vessel remodeling|outflow tract septum morphogenesis|cardiac right ventricle morphogenesis|pulmonary myocardium development|extracellular space|integral component of plasma membrane|immune response|axon guidance|post-embryonic development|neural tube development|semaphorin receptor binding|positive regulation of cell migration|response to drug|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|limb bud formation|dichotomous subdivision of terminal units involved in salivary gland branching|extracellular exosome|semaphorin-plexin signaling pathway|cardiac endothelial to mesenchymal transition|positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis hsa04360 Axon guidance SEMA3D 20.61360226 28.41876711 12.80843742 0.450703486 -1.149749485 0.302959014 1 0.183421728 0.086229849 223117 semaphorin 3D "GO:0001755,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA3E 11.5086901 12.17947162 10.83790858 0.889850473 -0.168365163 0.971008791 1 0.083662996 0.077654456 9723 semaphorin 3E "GO:0001569,GO:0001755,GO:0001953,GO:0002040,GO:0005515,GO:0005576,GO:0005615,GO:0005887,GO:0007411,GO:0008360,GO:0016525,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050808,GO:0050919,GO:0071526,GO:2000249" branching involved in blood vessel morphogenesis|neural crest cell migration|negative regulation of cell-matrix adhesion|sprouting angiogenesis|protein binding|extracellular region|extracellular space|integral component of plasma membrane|axon guidance|regulation of cell shape|negative regulation of angiogenesis|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|synapse organization|negative chemotaxis|semaphorin-plexin signaling pathway|regulation of actin cytoskeleton reorganization hsa04360 Axon guidance SEMA3F 109.5585831 181.6771183 37.44004783 0.20608015 -2.278722545 0.000938388 0.087115842 1.942843143 0.417628214 6405 semaphorin 3F "GO:0001755,GO:0005615,GO:0005887,GO:0007411,GO:0021612,GO:0021637,GO:0021675,GO:0021785,GO:0030215,GO:0030335,GO:0036486,GO:0045499,GO:0048843,GO:0048846,GO:0050919,GO:0061549,GO:0071526,GO:0097490,GO:0097491,GO:0098978,GO:0099175,GO:1901166,GO:1902285,GO:1902287" neural crest cell migration|extracellular space|integral component of plasma membrane|axon guidance|facial nerve structural organization|trigeminal nerve structural organization|nerve development|branchiomotor neuron axon guidance|semaphorin receptor binding|positive regulation of cell migration|ventral trunk neural crest cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|axon extension involved in axon guidance|negative chemotaxis|sympathetic ganglion development|semaphorin-plexin signaling pathway|sympathetic neuron projection extension|sympathetic neuron projection guidance|glutamatergic synapse|regulation of postsynapse organization|neural crest cell migration involved in autonomic nervous system development|semaphorin-plexin signaling pathway involved in neuron projection guidance|semaphorin-plexin signaling pathway involved in axon guidance hsa04360 Axon guidance SEMA3G 8.463822196 6.08973581 10.83790858 1.779700946 0.831634837 0.617753532 1 0.060989447 0.113218568 56920 semaphorin 3G "GO:0001755,GO:0005102,GO:0005515,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0030517,GO:0045499,GO:0048843,GO:0050919,GO:0070062,GO:0071526" neural crest cell migration|signaling receptor binding|protein binding|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|negative regulation of axon extension|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|extracellular exosome|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA4B 7593.243114 9316.280834 5870.205394 0.630101808 -0.666343146 0.043800966 0.952191822 115.2226516 75.72940082 10509 semaphorin 4B "GO:0001755,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0045202,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|synapse|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA4C 907.7937367 833.27885 982.3086233 1.178847421 0.237377001 0.508739022 1 8.703368555 10.70190033 54910 semaphorin 4C "GO:0001755,GO:0001843,GO:0005515,GO:0005615,GO:0005887,GO:0007411,GO:0014069,GO:0021535,GO:0021549,GO:0030215,GO:0030335,GO:0030672,GO:0032874,GO:0042692,GO:0045499,GO:0048843,GO:0050919,GO:0071526,GO:0098839" neural crest cell migration|neural tube closure|protein binding|extracellular space|integral component of plasma membrane|axon guidance|postsynaptic density|cell migration in hindbrain|cerebellum development|semaphorin receptor binding|positive regulation of cell migration|synaptic vesicle membrane|positive regulation of stress-activated MAPK cascade|muscle cell differentiation|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway|postsynaptic density membrane hsa04360 Axon guidance SEMA4D 264.5689819 237.4996966 291.6382673 1.227952168 0.296254365 0.550043319 1 0.956922974 1.225672272 10507 semaphorin 4D "GO:0000122,GO:0001755,GO:0001934,GO:0004888,GO:0005102,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006955,GO:0007155,GO:0007162,GO:0007411,GO:0008360,GO:0010693,GO:0014068,GO:0030215,GO:0030335,GO:0031344,GO:0038023,GO:0043066,GO:0043547,GO:0043931,GO:0045499,GO:0045668,GO:0048672,GO:0048814,GO:0048843,GO:0050731,GO:0050732,GO:0050919,GO:0070486,GO:0071526,GO:1900220,GO:1905704" negative regulation of transcription by RNA polymerase II|neural crest cell migration|positive regulation of protein phosphorylation|transmembrane signaling receptor activity|signaling receptor binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|immune response|cell adhesion|negative regulation of cell adhesion|axon guidance|regulation of cell shape|negative regulation of alkaline phosphatase activity|positive regulation of phosphatidylinositol 3-kinase signaling|semaphorin receptor binding|positive regulation of cell migration|regulation of cell projection organization|signaling receptor activity|negative regulation of apoptotic process|positive regulation of GTPase activity|ossification involved in bone maturation|chemorepellent activity|negative regulation of osteoblast differentiation|positive regulation of collateral sprouting|regulation of dendrite morphogenesis|negative regulation of axon extension involved in axon guidance|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of peptidyl-tyrosine phosphorylation|negative chemotaxis|leukocyte aggregation|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis|positive regulation of inhibitory synapse assembly hsa04360 Axon guidance SEMA4F 662.095958 572.4351662 751.7567498 1.313260949 0.393153613 0.304067899 1 3.076708239 4.214570032 10505 ssemaphorin 4F "GO:0001755,GO:0005615,GO:0005783,GO:0005886,GO:0005887,GO:0007267,GO:0007399,GO:0007411,GO:0014069,GO:0016020,GO:0030215,GO:0030335,GO:0030425,GO:0031290,GO:0043204,GO:0045211,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|extracellular space|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cell-cell signaling|nervous system development|axon guidance|postsynaptic density|membrane|semaphorin receptor binding|positive regulation of cell migration|dendrite|retinal ganglion cell axon guidance|perikaryon|postsynaptic membrane|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA4G 473.2720861 528.7920595 417.7521126 0.790012076 -0.340053389 0.412644989 1 5.670432426 4.672677834 57715 semaphorin 4G "GO:0001755,GO:0005515,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|protein binding|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA5A 357.5453328 565.3304744 149.7601913 0.264907338 -1.916440285 3.49E-05 0.006854318 1.785593649 0.493392509 9037 semaphorin 5A "GO:0001755,GO:0001938,GO:0002043,GO:0005886,GO:0007155,GO:0007162,GO:0007267,GO:0007399,GO:0007411,GO:0007413,GO:0016020,GO:0016021,GO:0021536,GO:0030215,GO:0030335,GO:0030836,GO:0035373,GO:0043395,GO:0045499,GO:0045545,GO:0045766,GO:0048675,GO:0048842,GO:0048843,GO:0050918,GO:0050919,GO:0051897,GO:0060326,GO:0070062,GO:0071526,GO:0090263,GO:1990256,GO:2000352,GO:2001028" neural crest cell migration|positive regulation of endothelial cell proliferation|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|plasma membrane|cell adhesion|negative regulation of cell adhesion|cell-cell signaling|nervous system development|axon guidance|axonal fasciculation|membrane|integral component of membrane|diencephalon development|semaphorin receptor binding|positive regulation of cell migration|positive regulation of actin filament depolymerization|chondroitin sulfate proteoglycan binding|heparan sulfate proteoglycan binding|chemorepellent activity|syndecan binding|positive regulation of angiogenesis|axon extension|positive regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|positive chemotaxis|negative chemotaxis|positive regulation of protein kinase B signaling|cell chemotaxis|extracellular exosome|semaphorin-plexin signaling pathway|positive regulation of canonical Wnt signaling pathway|signal clustering|negative regulation of endothelial cell apoptotic process|positive regulation of endothelial cell chemotaxis hsa04360 Axon guidance SEMA6A 10.61250034 18.26920743 2.95579325 0.161790995 -2.627796782 0.074453897 1 0.116753427 0.019703343 57556 semaphorin 6A "GO:0001755,GO:0005515,GO:0005615,GO:0005887,GO:0006915,GO:0007010,GO:0007166,GO:0007399,GO:0007411,GO:0009887,GO:0016021,GO:0016525,GO:0030215,GO:0030335,GO:0030424,GO:0035924,GO:0045499,GO:0048843,GO:0050919,GO:0070373,GO:0071526,GO:0106089,GO:1900747,GO:1903671,GO:2001224" neural crest cell migration|protein binding|extracellular space|integral component of plasma membrane|apoptotic process|cytoskeleton organization|cell surface receptor signaling pathway|nervous system development|axon guidance|animal organ morphogenesis|integral component of membrane|negative regulation of angiogenesis|semaphorin receptor binding|positive regulation of cell migration|axon|cellular response to vascular endothelial growth factor stimulus|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|negative regulation of ERK1 and ERK2 cascade|semaphorin-plexin signaling pathway|negative regulation of cell adhesion involved in sprouting angiogenesis|negative regulation of vascular endothelial growth factor signaling pathway|negative regulation of sprouting angiogenesis|positive regulation of neuron migration hsa04360 Axon guidance SEMA6B 393.0148518 565.3304744 220.6992293 0.390389762 -1.357012877 0.002138722 0.147899168 7.1153067 2.897396787 10501 semaphorin 6B "GO:0001755,GO:0005515,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|protein binding|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA6C 223.718365 139.0489677 308.3877624 2.217835684 1.149152483 0.028237589 0.744615344 1.061072725 2.454654925 10500 semaphorin 6C "GO:0001755,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA6D 58.57325225 63.94222601 53.20427849 0.832067975 -0.265226703 0.757445459 1 0.337232966 0.292687893 80031 semaphorin 6D "GO:0001755,GO:0005615,GO:0005794,GO:0005886,GO:0005887,GO:0007411,GO:0014911,GO:0014912,GO:0021591,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|extracellular space|Golgi apparatus|plasma membrane|integral component of plasma membrane|axon guidance|positive regulation of smooth muscle cell migration|negative regulation of smooth muscle cell migration|ventricular system development|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA7A 823.9732701 996.6867609 651.2597793 0.653424732 -0.613907034 0.093164338 1 14.45965865 9.855292956 8482 semaphorin 7A (John Milton Hagen blood group) "GO:0001649,GO:0001755,GO:0001934,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007229,GO:0007411,GO:0009897,GO:0016020,GO:0021988,GO:0030215,GO:0030335,GO:0031225,GO:0045499,GO:0045773,GO:0048675,GO:0048843,GO:0050727,GO:0050919,GO:0060907,GO:0062023,GO:0070374,GO:0071526" osteoblast differentiation|neural crest cell migration|positive regulation of protein phosphorylation|integrin binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|integrin-mediated signaling pathway|axon guidance|external side of plasma membrane|membrane|olfactory lobe development|semaphorin receptor binding|positive regulation of cell migration|anchored component of membrane|chemorepellent activity|positive regulation of axon extension|axon extension|negative regulation of axon extension involved in axon guidance|regulation of inflammatory response|negative chemotaxis|positive regulation of macrophage cytokine production|collagen-containing extracellular matrix|positive regulation of ERK1 and ERK2 cascade|semaphorin-plexin signaling pathway hsa04360 Axon guidance SENP1 942.319807 869.8172649 1014.822349 1.166707526 0.222442947 0.533080211 1 8.695849968 10.58254118 29843 SUMO specific peptidase 1 "GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005925,GO:0006508,GO:0006919,GO:0016925,GO:0016926,GO:0016929,GO:0031965,GO:0045944,GO:0070140,GO:0097190" endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|focal adhesion|proteolysis|activation of cysteine-type endopeptidase activity involved in apoptotic process|protein sumoylation|protein desumoylation|SUMO-specific protease activity|nuclear membrane|positive regulation of transcription by RNA polymerase II|SUMO-specific isopeptidase activity|apoptotic signaling pathway SENP2 1122.48414 927.6697551 1317.298525 1.420008055 0.505899114 0.143598857 1 15.40432802 22.81652471 59343 SUMO specific peptidase 2 "GO:0001934,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005829,GO:0007507,GO:0009950,GO:0015031,GO:0016055,GO:0016605,GO:0016925,GO:0016926,GO:0016929,GO:0019904,GO:0030111,GO:0031397,GO:0031398,GO:0031648,GO:0031965,GO:0032091,GO:0032875,GO:0035562,GO:0045444,GO:0045944,GO:0051028,GO:0060707,GO:0060711,GO:0070139,GO:0070140,GO:2000045" positive regulation of protein phosphorylation|protein binding|nucleus|nuclear pore|nucleoplasm|cytosol|heart development|dorsal/ventral axis specification|protein transport|Wnt signaling pathway|PML body|protein sumoylation|protein desumoylation|SUMO-specific protease activity|protein domain specific binding|regulation of Wnt signaling pathway|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|protein destabilization|nuclear membrane|negative regulation of protein binding|regulation of DNA endoreduplication|negative regulation of chromatin binding|fat cell differentiation|positive regulation of transcription by RNA polymerase II|mRNA transport|trophoblast giant cell differentiation|labyrinthine layer development|SUMO-specific endopeptidase activity|SUMO-specific isopeptidase activity|regulation of G1/S transition of mitotic cell cycle "hsa03013,hsa04310" RNA transport|Wnt signaling pathway SENP3 1810.445146 1752.828957 1868.061334 1.065740799 0.0918566 0.778544377 1 34.58301639 38.44416143 26168 SUMO specific peptidase 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008234,GO:0016926,GO:0016929,GO:0071339" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|cysteine-type peptidase activity|protein desumoylation|SUMO-specific protease activity|MLL1 complex SENP5 666.675384 616.0782728 717.2724952 1.164255464 0.219407653 0.566893745 1 9.384117631 11.3961369 205564 SUMO specific peptidase 5 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0007049,GO:0016925,GO:0016926,GO:0016929,GO:0019783,GO:0051301" protein binding|nucleus|nucleoplasm|nucleolus|centrosome|cytosol|cell cycle|protein sumoylation|protein desumoylation|SUMO-specific protease activity|ubiquitin-like protein-specific protease activity|cell division SENP6 943.3023498 903.3108119 983.2938877 1.088544358 0.122400198 0.732922481 1 7.772596998 8.825274275 26054 SUMO specific peptidase 6 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016925,GO:0016926,GO:0070139,GO:0070646,GO:0090169,GO:0090234" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein sumoylation|protein desumoylation|SUMO-specific endopeptidase activity|protein modification by small protein removal|regulation of spindle assembly|regulation of kinetochore assembly SENP7 382.7452882 368.4290165 397.0615599 1.077715223 0.107976009 0.810633672 1 2.817398452 3.167146984 57337 SUMO specific peptidase 7 "GO:0005515,GO:0005634,GO:0005737,GO:0016926,GO:0070139" protein binding|nucleus|cytoplasm|protein desumoylation|SUMO-specific endopeptidase activity SENP8 51.87211802 43.64310664 60.10112941 1.377104749 0.461638302 0.591884697 1 0.44653927 0.641420098 123228 "SUMO peptidase family member, NEDD8 specific" "GO:0005515,GO:0005829,GO:0016579,GO:0019784,GO:0043687" protein binding|cytosol|protein deubiquitination|NEDD8-specific protease activity|post-translational protein modification SEPHS1 1802.639981 1724.41019 1880.869771 1.090732229 0.125296969 0.700756036 1 26.09360406 29.68712519 22929 selenophosphate synthetase 1 "GO:0004756,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005886,GO:0006464,GO:0016260,GO:0016310,GO:0031965,GO:0042802,GO:0046872" "selenide, water dikinase activity|protein binding|ATP binding|GTP binding|cytoplasm|plasma membrane|cellular protein modification process|selenocysteine biosynthetic process|phosphorylation|nuclear membrane|identical protein binding|metal ion binding" hsa00450 Selenocompound metabolism SEPHS2 1188.425103 1259.560357 1117.289848 0.887047486 -0.172916756 0.61471903 1 28.4279361 26.3031723 22928 selenophosphate synthetase 2 "GO:0001887,GO:0004756,GO:0005524,GO:0005575,GO:0005737,GO:0005829,GO:0016259,GO:0016260,GO:0016310,GO:0046872" "selenium compound metabolic process|selenide, water dikinase activity|ATP binding|cellular_component|cytoplasm|cytosol|selenocysteine metabolic process|selenocysteine biosynthetic process|phosphorylation|metal ion binding" hsa00450 Selenocompound metabolism SEPSECS 249.8790904 243.5894324 256.1687483 1.051641468 0.072642936 0.89250035 1 2.003726721 2.197971831 51091 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase "GO:0000049,GO:0001514,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016259,GO:0016785,GO:0097056" "tRNA binding|selenocysteine incorporation|protein binding|nucleus|cytoplasm|cytosol|selenocysteine metabolic process|transferase activity, transferring selenium-containing groups|selenocysteinyl-tRNA(Sec) biosynthetic process" "hsa00450,hsa00970" Selenocompound metabolism|Aminoacyl-tRNA biosynthesis SEPTIN1 22.94315132 19.2841634 26.60213925 1.379481116 0.464125707 0.688442458 1 0.643395814 0.925784532 1731 septin 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005815,GO:0005940,GO:0008021,GO:0015630,GO:0017157,GO:0030496,GO:0031105,GO:0032153,GO:0034613,GO:0042802,GO:0060090,GO:0061640" GTPase activity|protein binding|GTP binding|microtubule organizing center|septin ring|synaptic vesicle|microtubule cytoskeleton|regulation of exocytosis|midbody|septin complex|cell division site|cellular protein localization|identical protein binding|molecular adaptor activity|cytoskeleton-dependent cytokinesis hsa05100 Bacterial invasion of epithelial cells SEPTIN10 1432.672201 1185.468571 1679.87583 1.417056404 0.502897184 0.131871028 1 10.83750921 16.0188947 151011 septin 10 "GO:0003924,GO:0005515,GO:0005525,GO:0005940,GO:0015630,GO:0031105,GO:0032153,GO:0034613,GO:0060090,GO:0061640" GTPase activity|protein binding|GTP binding|septin ring|microtubule cytoskeleton|septin complex|cell division site|cellular protein localization|molecular adaptor activity|cytoskeleton-dependent cytokinesis SEPTIN11 4898.48034 4967.194509 4829.76617 0.972332805 -0.040477898 0.90016207 1 36.62942322 37.15018222 55752 septin 11 "GO:0001725,GO:0003924,GO:0005515,GO:0005525,GO:0005940,GO:0015630,GO:0030424,GO:0031105,GO:0032153,GO:0034613,GO:0043197,GO:0050807,GO:0060090,GO:0061640,GO:0098978,GO:0098982,GO:0099629" stress fiber|GTPase activity|protein binding|GTP binding|septin ring|microtubule cytoskeleton|axon|septin complex|cell division site|cellular protein localization|dendritic spine|regulation of synapse organization|molecular adaptor activity|cytoskeleton-dependent cytokinesis|glutamatergic synapse|GABA-ergic synapse|postsynaptic specialization of symmetric synapse "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SEPTIN2 6161.227334 5380.281588 6942.173079 1.290299209 0.367705653 0.258020346 1 62.91671253 84.67834922 4735 septin 2 "GO:0000145,GO:0000777,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005886,GO:0005930,GO:0005938,GO:0005940,GO:0007224,GO:0007283,GO:0008021,GO:0015629,GO:0015630,GO:0017157,GO:0030496,GO:0031105,GO:0031175,GO:0032153,GO:0032154,GO:0032391,GO:0034613,GO:0045171,GO:0045296,GO:0048471,GO:0060090,GO:0060170,GO:0060271,GO:0061640,GO:0070062,GO:0097227,GO:0097730" exocyst|condensed chromosome kinetochore|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|spindle|plasma membrane|axoneme|cell cortex|septin ring|smoothened signaling pathway|spermatogenesis|synaptic vesicle|actin cytoskeleton|microtubule cytoskeleton|regulation of exocytosis|midbody|septin complex|neuron projection development|cell division site|cleavage furrow|photoreceptor connecting cilium|cellular protein localization|intercellular bridge|cadherin binding|perinuclear region of cytoplasm|molecular adaptor activity|ciliary membrane|cilium assembly|cytoskeleton-dependent cytokinesis|extracellular exosome|sperm annulus|non-motile cilium "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SEPTIN3 184.5656098 89.31612522 279.8150943 3.132861996 1.64748122 0.003577273 0.215494916 0.681462286 2.226891307 55964 septin 3 "GO:0003674,GO:0003924,GO:0005515,GO:0005525,GO:0005940,GO:0015630,GO:0031105,GO:0032153,GO:0034613,GO:0042802,GO:0043005,GO:0060090,GO:0061640,GO:0098793,GO:0099569" molecular_function|GTPase activity|protein binding|GTP binding|septin ring|microtubule cytoskeleton|septin complex|cell division site|cellular protein localization|identical protein binding|neuron projection|molecular adaptor activity|cytoskeleton-dependent cytokinesis|presynapse|presynaptic cytoskeleton "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SEPTIN4 42.185499 21.31407534 63.05692266 2.95846391 1.564848296 0.084280302 1 0.246682524 0.761238226 5414 septin 4 "GO:0000287,GO:0003924,GO:0005198,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005739,GO:0005741,GO:0005829,GO:0005940,GO:0006915,GO:0007283,GO:0008021,GO:0015630,GO:0017157,GO:0030154,GO:0031105,GO:0031398,GO:0032153,GO:0034613,GO:0042802,GO:0042981,GO:0043065,GO:0060090,GO:0061640,GO:0097227,GO:2001244" magnesium ion binding|GTPase activity|structural molecule activity|protein binding|GTP binding|nucleus|nucleoplasm|mitochondrion|mitochondrial outer membrane|cytosol|septin ring|apoptotic process|spermatogenesis|synaptic vesicle|microtubule cytoskeleton|regulation of exocytosis|cell differentiation|septin complex|positive regulation of protein ubiquitination|cell division site|cellular protein localization|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|molecular adaptor activity|cytoskeleton-dependent cytokinesis|sperm annulus|positive regulation of intrinsic apoptotic signaling pathway "hsa04210,hsa04215" Apoptosis|Apoptosis - multiple species SEPTIN5 527.1431867 405.9823873 648.3039861 1.596877121 0.675253303 0.094527398 1 8.542407852 14.22878218 5413 septin 5 "GO:0003924,GO:0005198,GO:0005515,GO:0005525,GO:0005886,GO:0005940,GO:0008021,GO:0015630,GO:0016080,GO:0017157,GO:0030534,GO:0031105,GO:0032153,GO:0034613,GO:0035176,GO:0042802,GO:0060090,GO:0061640,GO:2000300" GTPase activity|structural molecule activity|protein binding|GTP binding|plasma membrane|septin ring|synaptic vesicle|microtubule cytoskeleton|synaptic vesicle targeting|regulation of exocytosis|adult behavior|septin complex|cell division site|cellular protein localization|social behavior|identical protein binding|molecular adaptor activity|cytoskeleton-dependent cytokinesis|regulation of synaptic vesicle exocytosis "hsa05012,hsa05022" Parkinson disease|Pathways of neurodegeneration - multiple diseases SEPTIN6 1381.362738 1382.370029 1380.355448 0.998542661 -0.002104029 0.997466873 1 12.69716454 13.22480574 23157 septin 6 "GO:0000281,GO:0000777,GO:0003924,GO:0005515,GO:0005525,GO:0005819,GO:0005940,GO:0007283,GO:0008021,GO:0015630,GO:0016032,GO:0030154,GO:0030496,GO:0031105,GO:0032153,GO:0032154,GO:0032173,GO:0034613,GO:0043679,GO:0060090,GO:0060271,GO:0061640,GO:0097227" mitotic cytokinesis|condensed chromosome kinetochore|GTPase activity|protein binding|GTP binding|spindle|septin ring|spermatogenesis|synaptic vesicle|microtubule cytoskeleton|viral process|cell differentiation|midbody|septin complex|cell division site|cleavage furrow|septin collar|cellular protein localization|axon terminus|molecular adaptor activity|cilium assembly|cytoskeleton-dependent cytokinesis|sperm annulus "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SEPTIN7 3276.385239 3394.012758 3158.757719 0.930685282 -0.103634703 0.745090994 1 59.02979837 57.30467783 989 septin 7 "GO:0000777,GO:0001725,GO:0003924,GO:0005198,GO:0005515,GO:0005525,GO:0005634,GO:0005819,GO:0005829,GO:0005930,GO:0005940,GO:0007283,GO:0015630,GO:0016324,GO:0016476,GO:0030154,GO:0030496,GO:0031105,GO:0032153,GO:0032154,GO:0034613,GO:0042802,GO:0045296,GO:0060090,GO:0060271,GO:0061640,GO:0070062,GO:0097227,GO:0097730,GO:1902857" condensed chromosome kinetochore|stress fiber|GTPase activity|structural molecule activity|protein binding|GTP binding|nucleus|spindle|cytosol|axoneme|septin ring|spermatogenesis|microtubule cytoskeleton|apical plasma membrane|regulation of embryonic cell shape|cell differentiation|midbody|septin complex|cell division site|cleavage furrow|cellular protein localization|identical protein binding|cadherin binding|molecular adaptor activity|cilium assembly|cytoskeleton-dependent cytokinesis|extracellular exosome|sperm annulus|non-motile cilium|positive regulation of non-motile cilium assembly hsa05131 Shigellosis SEPTIN8 3342.826253 2716.022171 3969.630334 1.461560357 0.547509408 0.085742775 1 22.72917076 34.65104016 23176 septin 8 "GO:0003924,GO:0005515,GO:0005525,GO:0005940,GO:0015630,GO:0030424,GO:0030672,GO:0031105,GO:0032153,GO:0034613,GO:0035542,GO:0060090,GO:0061640,GO:0098793" GTPase activity|protein binding|GTP binding|septin ring|microtubule cytoskeleton|axon|synaptic vesicle membrane|septin complex|cell division site|cellular protein localization|regulation of SNARE complex assembly|molecular adaptor activity|cytoskeleton-dependent cytokinesis|presynapse "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SEPTIN9 4111.038557 4312.54791 3909.529205 0.906547426 -0.141545599 0.657445426 1 35.659647 33.71968418 10801 septin 9 "GO:0001725,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005874,GO:0005930,GO:0005940,GO:0015629,GO:0015630,GO:0031105,GO:0032153,GO:0034613,GO:0045296,GO:0048471,GO:0060090,GO:0061640,GO:0097730,GO:1902857" stress fiber|GTPase activity|protein binding|GTP binding|cytoplasm|microtubule|axoneme|septin ring|actin cytoskeleton|microtubule cytoskeleton|septin complex|cell division site|cellular protein localization|cadherin binding|perinuclear region of cytoplasm|molecular adaptor activity|cytoskeleton-dependent cytokinesis|non-motile cilium|positive regulation of non-motile cilium assembly "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SERAC1 176.960121 175.5873825 178.3328594 1.015635958 0.022383378 0.979426737 1 2.050941303 2.172737346 84947 serine active site containing 1 "GO:0003674,GO:0005739,GO:0005783,GO:0008654,GO:0016021,GO:0030198,GO:0031012,GO:0032367,GO:0036148,GO:0044233" molecular_function|mitochondrion|endoplasmic reticulum|phospholipid biosynthetic process|integral component of membrane|extracellular matrix organization|extracellular matrix|intracellular cholesterol transport|phosphatidylglycerol acyl-chain remodeling|mitochondria-associated endoplasmic reticulum membrane SERBP1 6231.321654 7141.230193 5321.413114 0.745167565 -0.424363216 0.19223664 1 53.77313657 41.79605021 26135 SERPINE1 mRNA binding protein 1 "GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030578,GO:0032183,GO:0042981,GO:0043488,GO:0045296,GO:0048471,GO:0070062" RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|membrane|PML body organization|SUMO binding|regulation of apoptotic process|regulation of mRNA stability|cadherin binding|perinuclear region of cytoplasm|extracellular exosome SERF1A 4.985705186 4.059823873 5.911586499 1.456118956 0.542128219 0.871693704 1 0.089827766 0.136434243 8293 small EDRK-rich factor 1A "GO:0003674,GO:0005515,GO:0005634,GO:0005829,GO:0007399,GO:0031648,GO:0032991,GO:1990000" molecular_function|protein binding|nucleus|cytosol|nervous system development|protein destabilization|protein-containing complex|amyloid fibril formation SERF1B 41.84132455 31.46363502 52.21901408 1.659662466 0.730889863 0.419881671 1 0.696165189 1.205169147 728492 small EDRK-rich factor 1B "GO:0003674,GO:0005515,GO:0005634,GO:0005829,GO:0007399,GO:0031648,GO:0032991,GO:1990000" molecular_function|protein binding|nucleus|cytosol|nervous system development|protein destabilization|protein-containing complex|amyloid fibril formation SERF2 4470.238698 4721.575165 4218.902232 0.893537026 -0.162400582 0.611642394 1 66.92726711 62.37801847 10169 small EDRK-rich factor 2 "GO:0003674,GO:0005634,GO:0005829,GO:0031648" molecular_function|nucleus|cytosol|protein destabilization SERGEF 181.8837214 209.0809295 154.6865134 0.739840376 -0.43471406 0.436240949 1 7.297871458 5.631838182 26297 secretion regulating guanine nucleotide exchange factor "GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0050709,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|negative regulation of protein secretion|regulation of catalytic activity SERHL2 14.4941749 14.20938356 14.77896625 1.040084968 0.056701392 1 1 0.472214665 0.51229984 253190 serine hydrolase like 2 "GO:0003674,GO:0005575,GO:0005777,GO:0008150,GO:0016787,GO:0048471" molecular_function|cellular_component|peroxisome|biological_process|hydrolase activity|perinuclear region of cytoplasm SERINC1 2825.695054 2186.215156 3465.174953 1.585010946 0.664492804 0.037425258 0.877615824 35.43170725 58.57877352 57515 serine incorporator 1 "GO:0005515,GO:0005789,GO:0005886,GO:0006658,GO:0006665,GO:0008654,GO:0016020,GO:0016021,GO:0019899,GO:0030674,GO:0044091,GO:1904219,GO:1904222" protein binding|endoplasmic reticulum membrane|plasma membrane|phosphatidylserine metabolic process|sphingolipid metabolic process|phospholipid biosynthetic process|membrane|integral component of membrane|enzyme binding|protein-macromolecule adaptor activity|membrane biogenesis|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|positive regulation of serine C-palmitoyltransferase activity SERINC2 365.2426179 451.6554059 278.8298299 0.617350808 -0.695837564 0.118501993 1 8.984584825 5.78556749 347735 serine incorporator 2 "GO:0006658,GO:0006665,GO:0016020,GO:0016021,GO:0070062,GO:1904219,GO:1904222" phosphatidylserine metabolic process|sphingolipid metabolic process|membrane|integral component of membrane|extracellular exosome|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|positive regulation of serine C-palmitoyltransferase activity SERINC3 6529.732309 5549.779235 7509.685383 1.35315029 0.436322084 0.181334531 1 62.03415136 87.55739059 10955 serine incorporator 3 "GO:0000139,GO:0005515,GO:0005886,GO:0006564,GO:0006658,GO:0006665,GO:0009597,GO:0016020,GO:0016021,GO:0016032,GO:0045087,GO:0048471,GO:0051607,GO:1902237" Golgi membrane|protein binding|plasma membrane|L-serine biosynthetic process|phosphatidylserine metabolic process|sphingolipid metabolic process|detection of virus|membrane|integral component of membrane|viral process|innate immune response|perinuclear region of cytoplasm|defense response to virus|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway SERINC4 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.096262059 0.058482768 619189 serine incorporator 4 "GO:0008654,GO:0016020,GO:0016021" phospholipid biosynthetic process|membrane|integral component of membrane SERINC5 349.4771495 283.1727152 415.7815838 1.468296773 0.554143596 0.219665156 1 2.008641324 3.076324662 256987 serine incorporator 5 "GO:0005794,GO:0005813,GO:0005829,GO:0005886,GO:0006564,GO:0006658,GO:0006665,GO:0008654,GO:0009597,GO:0016020,GO:0016021,GO:0016032,GO:0042552,GO:0043209,GO:0043231,GO:0045087,GO:0048471,GO:0051607,GO:0070062,GO:1904219,GO:1904222" Golgi apparatus|centrosome|cytosol|plasma membrane|L-serine biosynthetic process|phosphatidylserine metabolic process|sphingolipid metabolic process|phospholipid biosynthetic process|detection of virus|membrane|integral component of membrane|viral process|myelination|myelin sheath|intracellular membrane-bounded organelle|innate immune response|perinuclear region of cytoplasm|defense response to virus|extracellular exosome|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|positive regulation of serine C-palmitoyltransferase activity SERP1 1081.258173 1039.314912 1123.201435 1.080713287 0.111983828 0.749228047 1 17.41814487 19.63488307 27230 stress associated endoplasmic reticulum protein 1 "GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0005840,GO:0005881,GO:0006464,GO:0006486,GO:0007009,GO:0015031,GO:0016021,GO:0030968,GO:0036498" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|ribosome|cytoplasmic microtubule|cellular protein modification process|protein glycosylation|plasma membrane organization|protein transport|integral component of membrane|endoplasmic reticulum unfolded protein response|IRE1-mediated unfolded protein response SERP2 15.01649866 16.23929549 13.79370183 0.849402724 -0.235479359 0.899738079 1 0.454399463 0.402594084 387923 stress associated endoplasmic reticulum protein family member 2 "GO:0005515,GO:0005789,GO:0006486,GO:0015031,GO:0016021,GO:0030968" protein binding|endoplasmic reticulum membrane|protein glycosylation|protein transport|integral component of membrane|endoplasmic reticulum unfolded protein response SERPINA1 352.7729117 508.4929402 197.0528833 0.387523342 -1.367644885 0.002720241 0.172290393 7.061522776 2.854382435 5265 serpin family A member 1 "GO:0000139,GO:0002020,GO:0002576,GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005788,GO:0005794,GO:0006888,GO:0006953,GO:0007596,GO:0010951,GO:0030134,GO:0031093,GO:0033116,GO:0042802,GO:0043231,GO:0043312,GO:0043687,GO:0044267,GO:0048208,GO:0062023,GO:0070062,GO:1904813" Golgi membrane|protease binding|platelet degranulation|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|acute-phase response|blood coagulation|negative regulation of endopeptidase activity|COPII-coated ER to Golgi transport vesicle|platelet alpha granule lumen|endoplasmic reticulum-Golgi intermediate compartment membrane|identical protein binding|intracellular membrane-bounded organelle|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|COPII vesicle coating|collagen-containing extracellular matrix|extracellular exosome|ficolin-1-rich granule lumen hsa04610 Complement and coagulation cascades SERPINA3 4.552456082 8.119647747 0.985264417 0.121343246 -3.042834281 0.175274214 1 0.228081816 0.028868366 12 serpin family A member 3 "GO:0002576,GO:0003677,GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0006953,GO:0006954,GO:0010951,GO:0019216,GO:0030277,GO:0031093,GO:0034774,GO:0035578,GO:0043312,GO:0062023,GO:0070062,GO:0072562" platelet degranulation|DNA binding|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|nucleus|acute-phase response|inflammatory response|negative regulation of endopeptidase activity|regulation of lipid metabolic process|maintenance of gastrointestinal epithelium|platelet alpha granule lumen|secretory granule lumen|azurophil granule lumen|neutrophil degranulation|collagen-containing extracellular matrix|extracellular exosome|blood microparticle SERPINA5 159.8461624 251.7090802 67.98324474 0.270086581 -1.888506135 0.001577607 0.123600503 5.596214633 1.576570147 5104 serpin family A member 5 "GO:0001972,GO:0002020,GO:0002080,GO:0004867,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0006869,GO:0007283,GO:0007342,GO:0007596,GO:0008201,GO:0009897,GO:0010951,GO:0016020,GO:0031091,GO:0031094,GO:0031210,GO:0032190,GO:0032991,GO:0036024,GO:0036025,GO:0036026,GO:0036027,GO:0036028,GO:0036029,GO:0036030,GO:0051346,GO:0061107,GO:0062023,GO:0070062,GO:0097181,GO:0097182,GO:0097183" retinoic acid binding|protease binding|acrosomal membrane|serine-type endopeptidase inhibitor activity|protein binding|glycosaminoglycan binding|extracellular region|extracellular space|lipid transport|spermatogenesis|fusion of sperm to egg plasma membrane involved in single fertilization|blood coagulation|heparin binding|external side of plasma membrane|negative regulation of endopeptidase activity|membrane|platelet alpha granule|platelet dense tubular network|phosphatidylcholine binding|acrosin binding|protein-containing complex|protein C inhibitor-TMPRSS7 complex|protein C inhibitor-TMPRSS11E complex|protein C inhibitor-PLAT complex|protein C inhibitor-PLAU complex|protein C inhibitor-thrombin complex|protein C inhibitor-KLK3 complex|protein C inhibitor-plasma kallikrein complex|negative regulation of hydrolase activity|seminal vesicle development|collagen-containing extracellular matrix|extracellular exosome|protein C inhibitor-coagulation factor V complex|protein C inhibitor-coagulation factor Xa complex|protein C inhibitor-coagulation factor XI complex hsa04610 Complement and coagulation cascades SERPINA6 29.70366865 43.64310664 15.76423066 0.361207803 -1.469099036 0.142075485 1 1.496526329 0.56384199 866 serpin family A member 6 "GO:0004867,GO:0005496,GO:0005615,GO:0008211,GO:0010951,GO:0070062" serine-type endopeptidase inhibitor activity|steroid binding|extracellular space|glucocorticoid metabolic process|negative regulation of endopeptidase activity|extracellular exosome SERPINB1 695.1238427 674.945719 715.3019664 1.059791841 0.083780926 0.827890649 1 10.93525899 12.08830961 1992 serpin family B member 1 "GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0010951,GO:0016020,GO:0030414,GO:0032691,GO:0034774,GO:0036464,GO:0043312,GO:0044342,GO:0062023,GO:0070062" serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|negative regulation of endopeptidase activity|membrane|peptidase inhibitor activity|negative regulation of interleukin-1 beta production|secretory granule lumen|cytoplasmic ribonucleoprotein granule|neutrophil degranulation|type B pancreatic cell proliferation|collagen-containing extracellular matrix|extracellular exosome SERPINB2 154.5608201 260.8436839 48.27795641 0.185083862 -2.433748986 8.58E-05 0.014137806 5.83258825 1.126019215 5055 serpin family B member 2 "GO:0004867,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0010951,GO:0035722,GO:0042060,GO:0042730,GO:0043066" serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|cytoplasm|plasma membrane|negative regulation of endopeptidase activity|interleukin-12-mediated signaling pathway|wound healing|fibrinolysis|negative regulation of apoptotic process hsa04610 Complement and coagulation cascades SERPINB5 122.6424093 99.4656849 145.8191336 1.466024527 0.55190924 0.385622183 1 3.349458807 5.121908397 5268 serpin family B member 5 "GO:0002009,GO:0004867,GO:0005515,GO:0005615,GO:0005737,GO:0010951,GO:0030198,GO:0050678,GO:0060512" morphogenesis of an epithelium|serine-type endopeptidase inhibitor activity|protein binding|extracellular space|cytoplasm|negative regulation of endopeptidase activity|extracellular matrix organization|regulation of epithelial cell proliferation|prostate gland morphogenesis "hsa04115,hsa05206" p53 signaling pathway|MicroRNAs in cancer SERPINB6 2065.898329 2108.063546 2023.733112 0.959996256 -0.058899316 0.855943989 1 20.74737307 20.7753613 5269 serpin family B member 6 "GO:0002020,GO:0004867,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007605,GO:0010951,GO:0030667,GO:0043312,GO:0062023,GO:0070062,GO:0070821,GO:0071470,GO:0097180,GO:0101003" protease binding|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|sensory perception of sound|negative regulation of endopeptidase activity|secretory granule membrane|neutrophil degranulation|collagen-containing extracellular matrix|extracellular exosome|tertiary granule membrane|cellular response to osmotic stress|serine protease inhibitor complex|ficolin-1-rich granule membrane hsa05146 Amoebiasis SERPINB7 22.5841311 28.41876711 16.74949508 0.589381482 -0.762726362 0.489235248 1 0.618260438 0.38008775 8710 serpin family B member 7 "GO:0004867,GO:0005615,GO:0005737,GO:0010951,GO:0032914,GO:0032967,GO:0072126,GO:0090362" serine-type endopeptidase inhibitor activity|extracellular space|cytoplasm|negative regulation of endopeptidase activity|positive regulation of transforming growth factor beta1 production|positive regulation of collagen biosynthetic process|positive regulation of glomerular mesangial cell proliferation|positive regulation of platelet-derived growth factor production SERPINB8 1889.156935 1812.71136 1965.602511 1.084343903 0.116822385 0.719081913 1 19.76053282 22.35021074 5271 serpin family B member 8 "GO:0004867,GO:0005515,GO:0005615,GO:0005737,GO:0005829,GO:0010951,GO:0062023,GO:0070062,GO:0090136" serine-type endopeptidase inhibitor activity|protein binding|extracellular space|cytoplasm|cytosol|negative regulation of endopeptidase activity|collagen-containing extracellular matrix|extracellular exosome|epithelial cell-cell adhesion SERPINB9 63.0217879 64.95718198 61.08639383 0.940410159 -0.088637971 0.931198009 1 0.724477453 0.710653854 5272 serpin family B member 9 "GO:0002020,GO:0002448,GO:0004867,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006915,GO:0006955,GO:0009617,GO:0010628,GO:0010951,GO:0016020,GO:0033668,GO:0042270,GO:0043027,GO:0043066,GO:0043154,GO:0062023,GO:0070062,GO:0071391" protease binding|mast cell mediated immunity|serine-type endopeptidase inhibitor activity|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|apoptotic process|immune response|response to bacterium|positive regulation of gene expression|negative regulation of endopeptidase activity|membrane|negative regulation by symbiont of host apoptotic process|protection from natural killer cell mediated cytotoxicity|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|collagen-containing extracellular matrix|extracellular exosome|cellular response to estrogen stimulus hsa05146 Amoebiasis SERPIND1 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.093334433 0.02362672 3053 serpin family D member 1 "GO:0004866,GO:0004867,GO:0005576,GO:0005615,GO:0005788,GO:0006935,GO:0007596,GO:0008201,GO:0010951,GO:0043687,GO:0044267,GO:0070062" endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|endoplasmic reticulum lumen|chemotaxis|blood coagulation|heparin binding|negative regulation of endopeptidase activity|post-translational protein modification|cellular protein metabolic process|extracellular exosome hsa04610 Complement and coagulation cascades SERPINE1 21599.60647 20049.4402 23149.77273 1.154634369 0.207436074 0.57291243 1 305.1182139 367.4756305 5054 serpin family E member 1 "GO:0001525,GO:0002020,GO:0002576,GO:0004867,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007623,GO:0010469,GO:0010757,GO:0010951,GO:0014912,GO:0030194,GO:0030195,GO:0030198,GO:0030336,GO:0031093,GO:0032757,GO:0033629,GO:0035491,GO:0042730,GO:0045766,GO:0045944,GO:0048260,GO:0050729,GO:0050829,GO:0051918,GO:0061044,GO:0061045,GO:0062023,GO:0070062,GO:0071222,GO:0090026,GO:0090399,GO:0097187,GO:1901331,GO:1902042,GO:2000098,GO:2000352" angiogenesis|protease binding|platelet degranulation|serine-type endopeptidase inhibitor activity|signaling receptor binding|protein binding|extracellular region|extracellular space|plasma membrane|circadian rhythm|regulation of signaling receptor activity|negative regulation of plasminogen activation|negative regulation of endopeptidase activity|negative regulation of smooth muscle cell migration|positive regulation of blood coagulation|negative regulation of blood coagulation|extracellular matrix organization|negative regulation of cell migration|platelet alpha granule lumen|positive regulation of interleukin-8 production|negative regulation of cell adhesion mediated by integrin|positive regulation of leukotriene production involved in inflammatory response|fibrinolysis|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of receptor-mediated endocytosis|positive regulation of inflammatory response|defense response to Gram-negative bacterium|negative regulation of fibrinolysis|negative regulation of vascular wound healing|negative regulation of wound healing|collagen-containing extracellular matrix|extracellular exosome|cellular response to lipopolysaccharide|positive regulation of monocyte chemotaxis|replicative senescence|dentinogenesis|positive regulation of odontoblast differentiation|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of endothelial cell apoptotic process "hsa04066,hsa04115,hsa04218,hsa04371,hsa04390,hsa04610,hsa04933,hsa05142" HIF-1 signaling pathway|p53 signaling pathway|Cellular senescence|Apelin signaling pathway|Hippo signaling pathway|Complement and coagulation cascades|AGE-RAGE signaling pathway in diabetic complications|Chagas disease SERPINE2 866.9982974 974.3577296 759.6388652 0.779630358 -0.359137827 0.320876716 1 19.17163235 15.59063353 5270 serpin family E member 2 "GO:0004867,GO:0005102,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0005829,GO:0007596,GO:0008201,GO:0008285,GO:0010757,GO:0010766,GO:0010951,GO:0010955,GO:0014067,GO:0021683,GO:0030195,GO:0030308,GO:0030334,GO:0031091,GO:0031232,GO:0031594,GO:0032940,GO:0033363,GO:0042177,GO:0042628,GO:0045861,GO:0045879,GO:0048505,GO:0048711,GO:0050974,GO:0051966,GO:0060291,GO:0060384,GO:0061108,GO:0062023,GO:0090331,GO:1903561" "serine-type endopeptidase inhibitor activity|signaling receptor binding|protein binding|glycosaminoglycan binding|extracellular region|extracellular space|cytosol|blood coagulation|heparin binding|negative regulation of cell population proliferation|negative regulation of plasminogen activation|negative regulation of sodium ion transport|negative regulation of endopeptidase activity|negative regulation of protein processing|negative regulation of phosphatidylinositol 3-kinase signaling|cerebellar granular layer morphogenesis|negative regulation of blood coagulation|negative regulation of cell growth|regulation of cell migration|platelet alpha granule|extrinsic component of external side of plasma membrane|neuromuscular junction|secretion by cell|secretory granule organization|negative regulation of protein catabolic process|mating plug formation|negative regulation of proteolysis|negative regulation of smoothened signaling pathway|regulation of timing of cell differentiation|positive regulation of astrocyte differentiation|detection of mechanical stimulus involved in sensory perception|regulation of synaptic transmission, glutamatergic|long-term synaptic potentiation|innervation|seminal vesicle epithelium development|collagen-containing extracellular matrix|negative regulation of platelet aggregation|extracellular vesicle" SERPINF1 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.030543042 0.092780149 5176 serpin family F member 1 "GO:0001822,GO:0004867,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0007568,GO:0007614,GO:0010447,GO:0010596,GO:0010629,GO:0010951,GO:0010976,GO:0016525,GO:0042470,GO:0042698,GO:0043203,GO:0046685,GO:0048471,GO:0050728,GO:0050769,GO:0060041,GO:0060770,GO:0062023,GO:0070062,GO:0071279,GO:0071300,GO:0071333,GO:0071549,GO:1901215,GO:1901652" kidney development|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|basement membrane|extracellular space|aging|short-term memory|response to acidic pH|negative regulation of endothelial cell migration|negative regulation of gene expression|negative regulation of endopeptidase activity|positive regulation of neuron projection development|negative regulation of angiogenesis|melanosome|ovulation cycle|axon hillock|response to arsenic-containing substance|perinuclear region of cytoplasm|negative regulation of inflammatory response|positive regulation of neurogenesis|retina development in camera-type eye|negative regulation of epithelial cell proliferation involved in prostate gland development|collagen-containing extracellular matrix|extracellular exosome|cellular response to cobalt ion|cellular response to retinoic acid|cellular response to glucose stimulus|cellular response to dexamethasone stimulus|negative regulation of neuron death|response to peptide hsa04310 Wnt signaling pathway SERPINF2 14.04608002 17.25425146 10.83790858 0.628129746 -0.670865504 0.617463255 1 0.347323914 0.227562123 5345 serpin family F member 2 "GO:0002020,GO:0002034,GO:0002576,GO:0004866,GO:0004867,GO:0005515,GO:0005576,GO:0005577,GO:0005615,GO:0006953,GO:0009986,GO:0010033,GO:0010757,GO:0010951,GO:0030199,GO:0031093,GO:0032967,GO:0042730,GO:0042803,GO:0045597,GO:0045944,GO:0046330,GO:0048514,GO:0048661,GO:0051496,GO:0051918,GO:0062023,GO:0070062,GO:0070374,GO:0071636,GO:0072562,GO:2000049" protease binding|maintenance of blood vessel diameter homeostasis by renin-angiotensin|platelet degranulation|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|fibrinogen complex|extracellular space|acute-phase response|cell surface|response to organic substance|negative regulation of plasminogen activation|negative regulation of endopeptidase activity|collagen fibril organization|platelet alpha granule lumen|positive regulation of collagen biosynthetic process|fibrinolysis|protein homodimerization activity|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|blood vessel morphogenesis|positive regulation of smooth muscle cell proliferation|positive regulation of stress fiber assembly|negative regulation of fibrinolysis|collagen-containing extracellular matrix|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|positive regulation of transforming growth factor beta production|blood microparticle|positive regulation of cell-cell adhesion mediated by cadherin hsa04610 Complement and coagulation cascades SERPING1 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.027518169 0.083591537 710 serpin family G member 1 "GO:0001869,GO:0002576,GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0006958,GO:0007597,GO:0008015,GO:0010951,GO:0030449,GO:0031093,GO:0042730,GO:0045087,GO:0062023,GO:0070062,GO:0072562" "negative regulation of complement activation, lectin pathway|platelet degranulation|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|complement activation, classical pathway|blood coagulation, intrinsic pathway|blood circulation|negative regulation of endopeptidase activity|regulation of complement activation|platelet alpha granule lumen|fibrinolysis|innate immune response|collagen-containing extracellular matrix|extracellular exosome|blood microparticle" "hsa04610,hsa05133" Complement and coagulation cascades|Pertussis SERPINH1 3498.44682 4632.25904 2364.6346 0.51047115 -0.970098667 0.002483984 0.161864992 91.32252967 48.62561031 871 serpin family H member 1 "GO:0003433,GO:0003723,GO:0004867,GO:0005515,GO:0005518,GO:0005615,GO:0005783,GO:0005788,GO:0005793,GO:0006986,GO:0010951,GO:0030199,GO:0032964,GO:0045121,GO:0051082,GO:0051604,GO:0062023" chondrocyte development involved in endochondral bone morphogenesis|RNA binding|serine-type endopeptidase inhibitor activity|protein binding|collagen binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|response to unfolded protein|negative regulation of endopeptidase activity|collagen fibril organization|collagen biosynthetic process|membrane raft|unfolded protein binding|protein maturation|collagen-containing extracellular matrix SERPINI1 23.37640043 15.22433953 31.52846133 2.070924737 1.050275123 0.329066853 1 0.48191193 1.040993274 5274 serpin family I member 1 "GO:0004867,GO:0005615,GO:0007417,GO:0007422,GO:0010951,GO:0010976,GO:0030155,GO:0034774,GO:0043025,GO:0043204,GO:0060205,GO:0070062" serine-type endopeptidase inhibitor activity|extracellular space|central nervous system development|peripheral nervous system development|negative regulation of endopeptidase activity|positive regulation of neuron projection development|regulation of cell adhesion|secretory granule lumen|neuronal cell body|perikaryon|cytoplasmic vesicle lumen|extracellular exosome SERTAD1 196.0215977 198.9313698 193.1118256 0.970745971 -0.042834281 0.947037023 1 4.834535553 4.895265876 29950 SERTA domain containing 1 "GO:0000079,GO:0005515,GO:0005634,GO:0005737,GO:0008284,GO:0045944,GO:0048096,GO:0140110" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|cytoplasm|positive regulation of cell population proliferation|positive regulation of transcription by RNA polymerase II|chromatin-mediated maintenance of transcription|transcription regulator activity SERTAD2 801.7469215 790.6506994 812.8431437 1.028068582 0.03993651 0.916792693 1 5.974883419 6.407187788 9792 SERTA domain containing 2 "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0030308,GO:0048096,GO:0140110" transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|negative regulation of cell growth|chromatin-mediated maintenance of transcription|transcription regulator activity SERTAD3 396.9249802 394.8178717 399.0320887 1.010673825 0.015317472 0.978349353 1 10.64190121 11.21879393 29946 SERTA domain containing 3 "GO:0005515,GO:0005634,GO:0006355,GO:0030308,GO:0045893" "protein binding|nucleus|regulation of transcription, DNA-templated|negative regulation of cell growth|positive regulation of transcription, DNA-templated" SERTAD4 323.5457918 295.3521868 351.7393967 1.19091516 0.25207064 0.58805166 1 2.737153947 3.400133567 56256 SERTA domain containing 4 "GO:0005515,GO:0005634" protein binding|nucleus SESN1 109.2495434 126.869496 91.62959074 0.722235002 -0.469459755 0.479267854 1 1.053877711 0.793934513 27244 sestrin 1 "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016239,GO:0016684,GO:0031932,GO:0034198,GO:0042149,GO:0055114,GO:0061700,GO:0070728,GO:0071233,GO:0072593,GO:0098869,GO:1901031,GO:1904262,GO:1990253" "fibrillar center|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|positive regulation of macroautophagy|oxidoreductase activity, acting on peroxide as acceptor|TORC2 complex|cellular response to amino acid starvation|cellular response to glucose starvation|oxidation-reduction process|GATOR2 complex|leucine binding|cellular response to leucine|reactive oxygen species metabolic process|cellular oxidant detoxification|regulation of response to reactive oxygen species|negative regulation of TORC1 signaling|cellular response to leucine starvation" "hsa04115,hsa04211" p53 signaling pathway|Longevity regulating pathway SESN2 344.399648 306.5167024 382.2825936 1.247183565 0.318673822 0.483582403 1 4.484110241 5.833411184 83667 sestrin 2 "GO:0001932,GO:0005092,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006111,GO:0006635,GO:0009749,GO:0016239,GO:0016684,GO:0030308,GO:0030330,GO:0031588,GO:0031932,GO:0032042,GO:0032542,GO:0032868,GO:0034198,GO:0034599,GO:0036091,GO:0042149,GO:0042593,GO:0043491,GO:0046323,GO:0061700,GO:0070328,GO:0070728,GO:0071230,GO:0071233,GO:0072593,GO:0098869,GO:1900182,GO:1901031,GO:1902010,GO:1904262,GO:1904504,GO:1990253,GO:1990316,GO:2000479" "regulation of protein phosphorylation|GDP-dissociation inhibitor activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|regulation of gluconeogenesis|fatty acid beta-oxidation|response to glucose|positive regulation of macroautophagy|oxidoreductase activity, acting on peroxide as acceptor|negative regulation of cell growth|DNA damage response, signal transduction by p53 class mediator|nucleotide-activated protein kinase complex|TORC2 complex|mitochondrial DNA metabolic process|sulfiredoxin activity|response to insulin|cellular response to amino acid starvation|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|cellular response to glucose starvation|glucose homeostasis|protein kinase B signaling|glucose import|GATOR2 complex|triglyceride homeostasis|leucine binding|cellular response to amino acid stimulus|cellular response to leucine|reactive oxygen species metabolic process|cellular oxidant detoxification|positive regulation of protein localization to nucleus|regulation of response to reactive oxygen species|negative regulation of translation in response to endoplasmic reticulum stress|negative regulation of TORC1 signaling|positive regulation of lipophagy|cellular response to leucine starvation|Atg1/ULK1 kinase complex|regulation of cAMP-dependent protein kinase activity" "hsa04115,hsa04150,hsa04211" p53 signaling pathway|mTOR signaling pathway|Longevity regulating pathway SESN3 6.941388244 3.044867905 10.83790858 3.559401892 1.831634837 0.281983226 1 0.01547224 0.057444196 143686 sestrin 3 "GO:0005515,GO:0005634,GO:0005737,GO:0016239,GO:0016684,GO:0031932,GO:0032868,GO:0034198,GO:0038203,GO:0042149,GO:0042593,GO:0046626,GO:0051896,GO:0055114,GO:0061700,GO:0070728,GO:0071233,GO:1901031,GO:1904262,GO:1990253" "protein binding|nucleus|cytoplasm|positive regulation of macroautophagy|oxidoreductase activity, acting on peroxide as acceptor|TORC2 complex|response to insulin|cellular response to amino acid starvation|TORC2 signaling|cellular response to glucose starvation|glucose homeostasis|regulation of insulin receptor signaling pathway|regulation of protein kinase B signaling|oxidation-reduction process|GATOR2 complex|leucine binding|cellular response to leucine|regulation of response to reactive oxygen species|negative regulation of TORC1 signaling|cellular response to leucine starvation" "hsa04115,hsa04211" p53 signaling pathway|Longevity regulating pathway SESTD1 482.0855259 457.7451417 506.4259101 1.106349066 0.145806645 0.726979148 1 2.164629001 2.497995065 91404 SEC14 and spectrin domain containing 1 "GO:0001786,GO:0005515,GO:0005545,GO:0005546,GO:0010314,GO:0031210,GO:0032266,GO:0034704,GO:0043325,GO:0045111,GO:0070273,GO:0070300,GO:0080025,GO:1904878" "phosphatidylserine binding|protein binding|1-phosphatidylinositol binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylcholine binding|phosphatidylinositol-3-phosphate binding|calcium channel complex|phosphatidylinositol-3,4-bisphosphate binding|intermediate filament cytoskeleton|phosphatidylinositol-4-phosphate binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel" SET 7561.978901 7717.725184 7406.232619 0.959639329 -0.059435809 0.857041435 1 105.4710076 105.5740211 6418 SET nuclear proto-oncogene "GO:0003677,GO:0003682,GO:0004864,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005811,GO:0005829,GO:0006260,GO:0006334,GO:0006337,GO:0016032,GO:0019888,GO:0032515,GO:0032991,GO:0035067,GO:0042393,GO:0043488,GO:0043524,GO:0045892,GO:0048471" "DNA binding|chromatin binding|protein phosphatase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|lipid droplet|cytosol|DNA replication|nucleosome assembly|nucleosome disassembly|viral process|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|protein-containing complex|negative regulation of histone acetylation|histone binding|regulation of mRNA stability|negative regulation of neuron apoptotic process|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm" SETBP1 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.006448667 0.004897255 26040 SET binding protein 1 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0016604" DNA binding|protein binding|nucleoplasm|cytosol|nuclear body SETD1A 1174.532924 1185.468571 1163.597276 0.981550506 -0.026865591 0.940178463 1 8.127765134 8.321463766 9739 "SET domain containing 1A, histone lysine methyltransferase" "GO:0000785,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0007420,GO:0008013,GO:0008134,GO:0016607,GO:0035097,GO:0042800,GO:0044648,GO:0045652,GO:0048188,GO:0080182,GO:0097692,GO:1902036,GO:1902275" chromatin|RNA binding|protein binding|nucleus|nucleoplasm|brain development|beta-catenin binding|transcription factor binding|nuclear speck|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|histone H3-K4 dimethylation|regulation of megakaryocyte differentiation|Set1C/COMPASS complex|histone H3-K4 trimethylation|histone H3-K4 monomethylation|regulation of hematopoietic stem cell differentiation|regulation of chromatin organization hsa00310 Lysine degradation SETD1B 1081.991059 1022.06066 1141.921459 1.117273664 0.159982602 0.646733001 1 5.948490786 6.932378791 23067 "SET domain containing 1B, histone lysine methyltransferase" "GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0016607,GO:0035097,GO:0042800,GO:0044648,GO:0048188,GO:0051568,GO:0080182,GO:0097692" RNA binding|protein binding|nucleoplasm|chromosome|nuclear speck|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|histone H3-K4 dimethylation|Set1C/COMPASS complex|histone H3-K4 methylation|histone H3-K4 trimethylation|histone H3-K4 monomethylation hsa00310 Lysine degradation SETD2 2502.414757 2481.567343 2523.262171 1.016801812 0.024038507 0.941226012 1 14.45458671 15.3305565 29072 "SET domain containing 2, histone lysine methyltransferase" "GO:0001525,GO:0001763,GO:0001843,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006298,GO:0006355,GO:0006368,GO:0010569,GO:0010793,GO:0016032,GO:0016279,GO:0018023,GO:0018024,GO:0018026,GO:0030900,GO:0032465,GO:0032727,GO:0034340,GO:0034728,GO:0035441,GO:0035987,GO:0043014,GO:0046872,GO:0046975,GO:0048332,GO:0048701,GO:0048863,GO:0048864,GO:0051607,GO:0060039,GO:0060669,GO:0060977,GO:0097198,GO:0097676,GO:1902850,GO:1905634" "angiogenesis|morphogenesis of a branching structure|neural tube closure|protein binding|nucleus|nucleoplasm|chromosome|mismatch repair|regulation of transcription, DNA-templated|transcription elongation from RNA polymerase II promoter|regulation of double-strand break repair via homologous recombination|regulation of mRNA export from nucleus|viral process|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|forebrain development|regulation of cytokinesis|positive regulation of interferon-alpha production|response to type I interferon|nucleosome organization|cell migration involved in vasculogenesis|endodermal cell differentiation|alpha-tubulin binding|metal ion binding|histone methyltransferase activity (H3-K36 specific)|mesoderm morphogenesis|embryonic cranial skeleton morphogenesis|stem cell differentiation|stem cell development|defense response to virus|pericardium development|embryonic placenta morphogenesis|coronary vasculature morphogenesis|histone H3-K36 trimethylation|histone H3-K36 dimethylation|microtubule cytoskeleton organization involved in mitosis|regulation of protein localization to chromatin" hsa00310 Lysine degradation SETD3 964.056245 1042.35978 885.7527105 0.849757184 -0.234877442 0.508530318 1 10.36556953 9.187639441 84193 "SET domain containing 3, actin histidine methyltransferase" "GO:0001102,GO:0003713,GO:0003779,GO:0005515,GO:0005654,GO:0005737,GO:0010452,GO:0016279,GO:0018021,GO:0018023,GO:0018026,GO:0018027,GO:0018064,GO:0030047,GO:0042800,GO:0045893,GO:0045944,GO:0046975,GO:0051149,GO:0051568,GO:0070472" "RNA polymerase II activating transcription factor binding|transcription coactivator activity|actin binding|protein binding|nucleoplasm|cytoplasm|histone H3-K36 methylation|protein-lysine N-methyltransferase activity|peptidyl-histidine methylation|peptidyl-lysine trimethylation|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|protein-histidine N-methyltransferase activity|actin modification|histone methyltransferase activity (H3-K4 specific)|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|histone methyltransferase activity (H3-K36 specific)|positive regulation of muscle cell differentiation|histone H3-K4 methylation|regulation of uterine smooth muscle contraction" SETD4 312.7051616 328.8457338 296.5645894 0.901834991 -0.149064607 0.754314074 1 4.205776848 3.956300196 54093 SET domain containing 4 "GO:0005634,GO:0005829,GO:0016279,GO:0018023,GO:0018026" nucleus|cytosol|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|peptidyl-lysine monomethylation SETD5 6138.305463 5833.966906 6442.64402 1.104333316 0.14317568 0.659509483 1 17.51347536 20.17383386 55209 SET domain containing 5 "GO:0000791,GO:0005634,GO:0005654,GO:0016569,GO:0016593,GO:0032784,GO:0035065,GO:0046974,GO:0046975,GO:0050890,GO:0051567,GO:0051963,GO:0097198,GO:1902275" "euchromatin|nucleus|nucleoplasm|covalent chromatin modification|Cdc73/Paf1 complex|regulation of DNA-templated transcription, elongation|regulation of histone acetylation|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K36 specific)|cognition|histone H3-K9 methylation|regulation of synapse assembly|histone H3-K36 trimethylation|regulation of chromatin organization" SETD6 89.95053422 87.28621328 92.61485516 1.061047921 0.085489816 0.919082828 1 0.702261918 0.77723088 79918 "SET domain containing 6, protein lysine methyltransferase" "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0016279,GO:0018026,GO:0019827,GO:0032088,GO:0034968,GO:0048863,GO:0050727,GO:0051059" protein binding|nucleus|nucleoplasm|cytosol|protein-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|stem cell population maintenance|negative regulation of NF-kappaB transcription factor activity|histone lysine methylation|stem cell differentiation|regulation of inflammatory response|NF-kappaB binding SETD7 2188.86314 2465.328047 1912.398233 0.77571755 -0.366396653 0.25311864 1 11.38196613 9.209516614 80854 "SET domain containing 7, histone lysine methyltransferase" "GO:0002039,GO:0003682,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0006325,GO:0006974,GO:0016279,GO:0018024,GO:0018026,GO:0018027,GO:0034968,GO:0045471,GO:0045893,GO:0051570,GO:0070828" "p53 binding|chromatin binding|protein binding|nucleoplasm|chromosome|nucleolus|chromatin organization|cellular response to DNA damage stimulus|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|histone lysine methylation|response to ethanol|positive regulation of transcription, DNA-templated|regulation of histone H3-K9 methylation|heterochromatin organization" "hsa00310,hsa04068" Lysine degradation|FoxO signaling pathway SETD9 107.4571639 139.0489677 75.86536007 0.54560175 -0.874079824 0.187496705 1 1.146774088 0.65263379 133383 SET domain containing 9 "GO:0005654,GO:0016278,GO:0032259,GO:1901796" nucleoplasm|lysine N-methyltransferase activity|methylation|regulation of signal transduction by p53 class mediator SETDB1 889.8605389 887.0715164 892.6495614 1.006288157 0.009043489 0.983455555 1 9.47028729 9.940344713 9869 SET domain bifurcated histone lysine methyltransferase 1 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0007265,GO:0008270,GO:0010629,GO:0018024,GO:0033273,GO:0043231,GO:0045471,GO:0045869,GO:0046974,GO:0051567,GO:0070828,GO:0090309,GO:1990841" DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|Ras protein signal transduction|zinc ion binding|negative regulation of gene expression|histone-lysine N-methyltransferase activity|response to vitamin|intracellular membrane-bounded organelle|response to ethanol|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|histone methyltransferase activity (H3-K9 specific)|histone H3-K9 methylation|heterochromatin organization|positive regulation of DNA methylation-dependent heterochromatin assembly|promoter-specific chromatin binding "hsa00310,hsa04550" Lysine degradation|Signaling pathways regulating pluripotency of stem cells chromosome_remodelling_factor SETDB2 35.9000465 29.43372308 42.36636991 1.439381956 0.525449478 0.587635936 1 0.238934803 0.358733056 83852 SET domain bifurcated histone lysine methyltransferase 2 "GO:0000278,GO:0001947,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0007059,GO:0008270,GO:0010629,GO:0045892,GO:0046974,GO:0051301,GO:0051567,GO:0070828,GO:0070986,GO:0090309" "mitotic cell cycle|heart looping|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|chromosome segregation|zinc ion binding|negative regulation of gene expression|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K9 specific)|cell division|histone H3-K9 methylation|heterochromatin organization|left/right axis specification|positive regulation of DNA methylation-dependent heterochromatin assembly" hsa00310 Lysine degradation SETMAR 118.3544556 143.1087915 93.60011957 0.654048704 -0.612530025 0.340652244 1 1.338248788 0.912983392 6419 SET domain and mariner transposase fusion gene "GO:0000014,GO:0000729,GO:0000737,GO:0000793,GO:0003677,GO:0003690,GO:0003697,GO:0004519,GO:0005515,GO:0005634,GO:0005730,GO:0006303,GO:0008270,GO:0008283,GO:0010452,GO:0015074,GO:0031297,GO:0035861,GO:0042800,GO:0042803,GO:0044547,GO:0044774,GO:0046975,GO:0051568,GO:0071157,GO:0090305,GO:0097676,GO:2000373,GO:2001034,GO:2001251" "single-stranded DNA endodeoxyribonuclease activity|DNA double-strand break processing|DNA catabolic process, endonucleolytic|condensed chromosome|DNA binding|double-stranded DNA binding|single-stranded DNA binding|endonuclease activity|protein binding|nucleus|nucleolus|double-strand break repair via nonhomologous end joining|zinc ion binding|cell population proliferation|histone H3-K36 methylation|DNA integration|replication fork processing|site of double-strand break|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|DNA topoisomerase binding|mitotic DNA integrity checkpoint|histone methyltransferase activity (H3-K36 specific)|histone H3-K4 methylation|negative regulation of cell cycle arrest|nucleic acid phosphodiester bond hydrolysis|histone H3-K36 dimethylation|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|positive regulation of double-strand break repair via nonhomologous end joining|negative regulation of chromosome organization" hsa00310 Lysine degradation SETSIP 12.53849185 15.22433953 9.852644165 0.64716398 -0.627796782 0.661450597 1 0.743547819 0.501925397 646817 SET like protein "GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0005811,GO:0006334,GO:0042393,GO:0045446,GO:0045944" chromatin binding|nucleus|nucleoplasm|cytoplasm|lipid droplet|nucleosome assembly|histone binding|endothelial cell differentiation|positive regulation of transcription by RNA polymerase II SETX 2817.560315 2539.419833 3095.700797 1.219058289 0.28576711 0.369512835 1 10.10787928 12.85287986 23064 senataxin "GO:0000165,GO:0000228,GO:0000781,GO:0001147,GO:0003677,GO:0003678,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006302,GO:0006310,GO:0006353,GO:0006369,GO:0006376,GO:0006396,GO:0006974,GO:0007283,GO:0007399,GO:0007623,GO:0008543,GO:0010976,GO:0016604,GO:0030154,GO:0030424,GO:0030426,GO:0032508,GO:0033120,GO:0034599,GO:0042802,GO:0043066,GO:0043491,GO:0044344,GO:0045171,GO:0045944,GO:0060566,GO:0070301,GO:0071300,GO:2000144,GO:2000806" "MAPK cascade|nuclear chromosome|chromosome, telomeric region|transcription termination site sequence-specific DNA binding|DNA binding|DNA helicase activity|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|double-strand break repair|DNA recombination|DNA-templated transcription, termination|termination of RNA polymerase II transcription|mRNA splice site selection|RNA processing|cellular response to DNA damage stimulus|spermatogenesis|nervous system development|circadian rhythm|fibroblast growth factor receptor signaling pathway|positive regulation of neuron projection development|nuclear body|cell differentiation|axon|growth cone|DNA duplex unwinding|positive regulation of RNA splicing|cellular response to oxidative stress|identical protein binding|negative regulation of apoptotic process|protein kinase B signaling|cellular response to fibroblast growth factor stimulus|intercellular bridge|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-templated transcription, termination|cellular response to hydrogen peroxide|cellular response to retinoic acid|positive regulation of DNA-templated transcription, initiation|positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled" hsa05014 Amyotrophic lateral sclerosis SEZ6L2 1443.588297 1325.532495 1561.6441 1.178125852 0.236493662 0.478196682 1 17.46904623 21.46726957 26470 seizure related 6 homolog like 2 "GO:0005789,GO:0005886,GO:0016021" endoplasmic reticulum membrane|plasma membrane|integral component of membrane SF1 4431.184174 5116.393037 3745.975312 0.732151593 -0.449785704 0.159758987 1 46.02615591 35.14970185 7536 splicing factor 1 "GO:0000245,GO:0000389,GO:0000398,GO:0003714,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005840,GO:0008270,GO:0042802,GO:0045131,GO:0045892,GO:0048024" "spliceosomal complex assembly|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|ribosome|zinc ion binding|identical protein binding|pre-mRNA branch point binding|negative regulation of transcription, DNA-templated|regulation of mRNA splicing, via spliceosome" SF3A1 2588.479411 2808.383164 2368.575657 0.843394764 -0.245720029 0.441019857 1 27.9439489 24.58298459 10291 splicing factor 3a subunit 1 "GO:0000389,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005684,GO:0005686,GO:0006397,GO:0016607,GO:0071004,GO:0071005,GO:0071013,GO:1903241" "mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2-type spliceosomal complex|U2 snRNP|mRNA processing|nuclear speck|U2-type prespliceosome|U2-type precatalytic spliceosome|catalytic step 2 spliceosome|U2-type prespliceosome assembly" hsa03040 Spliceosome SF3A2 1076.99323 983.4923334 1170.494127 1.190140571 0.251131984 0.471060724 1 30.76616253 38.19332951 8175 splicing factor 3a subunit 2 "GO:0000245,GO:0000389,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005686,GO:0006397,GO:0008270,GO:0010976,GO:0016607,GO:0071004,GO:0071005,GO:0071013,GO:1903241" "spliceosomal complex assembly|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2 snRNP|mRNA processing|zinc ion binding|positive regulation of neuron projection development|nuclear speck|U2-type prespliceosome|U2-type precatalytic spliceosome|catalytic step 2 spliceosome|U2-type prespliceosome assembly" hsa03040 Spliceosome SF3A3 1856.872577 1929.431296 1784.313858 0.924787455 -0.112806267 0.728800388 1 35.22670819 33.98051225 10946 splicing factor 3a subunit 3 "GO:0000375,GO:0000389,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005686,GO:0006397,GO:0008270,GO:0016607,GO:0071005,GO:0071013,GO:1903241" "RNA splicing, via transesterification reactions|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2 snRNP|mRNA processing|zinc ion binding|nuclear speck|U2-type precatalytic spliceosome|catalytic step 2 spliceosome|U2-type prespliceosome assembly" hsa03040 Spliceosome SF3B1 5328.378027 5224.993325 5431.762728 1.039573142 0.055991267 0.862469579 1 32.42983814 35.16541618 23451 splicing factor 3b subunit 1 "GO:0000245,GO:0000375,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005686,GO:0005689,GO:0008380,GO:0016607,GO:0034693,GO:0045815,GO:0071004,GO:0071005,GO:0071013,GO:1990935" "spliceosomal complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2 snRNP|U12-type spliceosomal complex|RNA splicing|nuclear speck|U11/U12 snRNP|positive regulation of gene expression, epigenetic|U2-type prespliceosome|U2-type precatalytic spliceosome|catalytic step 2 spliceosome|splicing factor binding" hsa03040 Spliceosome SF3B2 4893.330093 4783.487479 5003.172707 1.045925745 0.064780432 0.840438545 1 73.97458494 80.70479154 10992 splicing factor 3b subunit 2 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005684,GO:0005686,GO:0005689,GO:0006397,GO:0008380,GO:0016032,GO:0016607,GO:0071005,GO:0071011,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2-type spliceosomal complex|U2 snRNP|U12-type spliceosomal complex|mRNA processing|RNA splicing|viral process|nuclear speck|U2-type precatalytic spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SF3B3 5897.178946 5717.24697 6077.110921 1.062943573 0.088065012 0.786088508 1 29.87602041 33.12446613 23450 splicing factor 3b subunit 3 "GO:0000375,GO:0000398,GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005689,GO:0005730,GO:0008380,GO:0042177,GO:0044877,GO:0071005,GO:0071013" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|nucleic acid binding|protein binding|nucleus|nucleoplasm|U12-type spliceosomal complex|nucleolus|RNA splicing|negative regulation of protein catabolic process|protein-containing complex binding|U2-type precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SF3B4 1844.690384 1938.5659 1750.814868 0.903149523 -0.146963238 0.651178378 1 63.58906993 59.90430855 10262 splicing factor 3b subunit 4 "GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005689,GO:0005730,GO:0006397,GO:0008380,GO:0048026,GO:0071005,GO:1990935" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|nucleolus|mRNA processing|RNA splicing|positive regulation of mRNA splicing, via spliceosome|U2-type precatalytic spliceosome|splicing factor binding" hsa03040 Spliceosome SF3B5 1479.546243 1561.002279 1398.090207 0.895636237 -0.159015195 0.632936829 1 114.5786356 107.0412649 83443 splicing factor 3b subunit 5 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005686,GO:0005689,GO:0071005,GO:0071011,GO:1990935" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U2 snRNP|U12-type spliceosomal complex|U2-type precatalytic spliceosome|precatalytic spliceosome|splicing factor binding" hsa03040 Spliceosome SF3B6 1068.191914 1089.047754 1047.336075 0.961698944 -0.05634276 0.874000477 1 84.72569403 84.9904647 51639 splicing factor 3b subunit 6 "GO:0000398,GO:0001825,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005684,GO:0005686,GO:0005689,GO:0071011,GO:0071013" "mRNA splicing, via spliceosome|blastocyst formation|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|U2-type spliceosomal complex|U2 snRNP|U12-type spliceosomal complex|precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SFI1 757.6111827 703.3644861 811.8578792 1.154249177 0.206954704 0.578776993 1 7.544034286 9.082787568 9814 SFI1 centrin binding protein "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0010923,GO:0019902,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|negative regulation of phosphatase activity|phosphatase binding|ciliary basal body-plasma membrane docking SFMBT1 608.0130571 546.046311 669.9798033 1.226965167 0.295094292 0.449841231 1 2.928968366 3.748545999 51460 Scm like with four mbt domains 1 "GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0007283,GO:0030154,GO:0042393,GO:0045892,GO:0048635" "chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|chromatin organization|spermatogenesis|cell differentiation|histone binding|negative regulation of transcription, DNA-templated|negative regulation of muscle organ development" other SFMBT2 113.2972431 100.4806409 126.1138453 1.255105901 0.327809099 0.620705713 1 0.602889466 0.789285269 57713 Scm like with four mbt domains 2 "GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0010629,GO:0016235,GO:0016604,GO:0016607,GO:0042393,GO:0043231,GO:0045892" "chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|negative regulation of gene expression|aggresome|nuclear body|nuclear speck|histone binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated" SFN 1466.862261 1131.675905 1802.048618 1.592371641 0.671177084 0.044031953 0.952191822 43.81910723 72.78198388 2810 stratifin "GO:0000079,GO:0001836,GO:0003334,GO:0005515,GO:0005615,GO:0005634,GO:0005739,GO:0005829,GO:0006469,GO:0006977,GO:0007165,GO:0008426,GO:0008630,GO:0010482,GO:0010839,GO:0019901,GO:0030307,GO:0031424,GO:0042802,GO:0043154,GO:0045296,GO:0045606,GO:0046827,GO:0051219,GO:0061024,GO:0061436,GO:0070062,GO:0071901,GO:1900740" "regulation of cyclin-dependent protein serine/threonine kinase activity|release of cytochrome c from mitochondria|keratinocyte development|protein binding|extracellular space|nucleus|mitochondrion|cytosol|negative regulation of protein kinase activity|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|signal transduction|protein kinase C inhibitor activity|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of epidermal cell division|negative regulation of keratinocyte proliferation|protein kinase binding|positive regulation of cell growth|keratinization|identical protein binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cadherin binding|positive regulation of epidermal cell differentiation|positive regulation of protein export from nucleus|phosphoprotein binding|membrane organization|establishment of skin barrier|extracellular exosome|negative regulation of protein serine/threonine kinase activity|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" "hsa04110,hsa04115,hsa04960" Cell cycle|p53 signaling pathway|Aldosterone-regulated sodium reabsorption SFPQ 5244.331906 5777.129372 4711.53444 0.815549408 -0.294155813 0.360889331 1 32.8127422 27.91314252 6421 splicing factor proline and glutamine rich "GO:0000122,GO:0000380,GO:0000398,GO:0000724,GO:0000785,GO:0000976,GO:0002218,GO:0003676,GO:0003677,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006397,GO:0008380,GO:0016363,GO:0016607,GO:0032839,GO:0042382,GO:0042752,GO:0042754,GO:0042803,GO:0042826,GO:0045087,GO:0045876,GO:0045892,GO:0045944,GO:0048511,GO:0070932,GO:0090575,GO:0098963,GO:1902177" "negative regulation of transcription by RNA polymerase II|alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|double-strand break repair via homologous recombination|chromatin|transcription regulatory region sequence-specific DNA binding|activation of innate immune response|nucleic acid binding|DNA binding|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|mRNA processing|RNA splicing|nuclear matrix|nuclear speck|dendrite cytoplasm|paraspeckles|regulation of circadian rhythm|negative regulation of circadian rhythm|protein homodimerization activity|histone deacetylase binding|innate immune response|positive regulation of sister chromatid cohesion|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|rhythmic process|histone H3 deacetylation|RNA polymerase II transcription regulator complex|dendritic transport of messenger ribonucleoprotein complex|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway" SFR1 290.4152244 354.219633 226.6108158 0.639746628 -0.644427457 0.17769615 1 7.789828397 5.198186128 119392 SWI5 dependent homologous recombination repair protein 1 "GO:0000724,GO:0005515,GO:0005634,GO:0030374,GO:0032798,GO:0045893,GO:0071391" "double-strand break repair via homologous recombination|protein binding|nucleus|nuclear receptor coactivator activity|Swi5-Sfr1 complex|positive regulation of transcription, DNA-templated|cellular response to estrogen stimulus" SFSWAP 1021.207024 975.3726856 1067.041363 1.093983232 0.129590626 0.713746145 1 11.54996157 13.17974884 6433 splicing factor SWAP "GO:0000380,GO:0000395,GO:0003723,GO:0005515,GO:0005634,GO:0048025" "alternative mRNA splicing, via spliceosome|mRNA 5'-splice site recognition|RNA binding|protein binding|nucleus|negative regulation of mRNA splicing, via spliceosome" SFT2D1 460.5042266 396.8477836 524.1606696 1.320810374 0.401423357 0.336602058 1 19.45686374 26.80582874 113402 SFT2 domain containing 1 "GO:0005515,GO:0015031,GO:0016021,GO:0016192" protein binding|protein transport|integral component of membrane|vesicle-mediated transport SFT2D2 1168.104456 1116.451565 1219.757348 1.092530465 0.12767351 0.71158944 1 5.121769309 5.836728593 375035 SFT2 domain containing 2 "GO:0003674,GO:0005515,GO:0008150,GO:0015031,GO:0016021,GO:0016192,GO:0070062" molecular_function|protein binding|biological_process|protein transport|integral component of membrane|vesicle-mediated transport|extracellular exosome SFT2D3 141.2854827 127.884452 154.6865134 1.209580297 0.274506544 0.655953234 1 1.729016643 2.181472825 84826 SFT2 domain containing 3 "GO:0015031,GO:0016021,GO:0016192" protein transport|integral component of membrane|vesicle-mediated transport SFXN1 1979.915576 2426.75972 1533.071432 0.631735981 -0.662606351 0.040426061 0.927001456 29.1801564 19.22822334 94081 sideroflexin 1 "GO:0005515,GO:0005739,GO:0006730,GO:0015194,GO:0015825,GO:0022857,GO:0022889,GO:0031305,GO:0042942,GO:0042945,GO:0140300,GO:1990542" protein binding|mitochondrion|one-carbon metabolic process|L-serine transmembrane transporter activity|L-serine transport|transmembrane transporter activity|serine transmembrane transporter activity|integral component of mitochondrial inner membrane|D-serine transport|D-serine transmembrane transporter activity|serine import into mitochondrion|mitochondrial transmembrane transport SFXN2 447.8927437 545.031355 350.7541323 0.643548539 -0.635879128 0.130689811 1 8.602030345 5.774284911 118980 sideroflexin 2 "GO:0005515,GO:0005739,GO:0022857,GO:0022889,GO:0031305,GO:0140300,GO:1990542" protein binding|mitochondrion|transmembrane transporter activity|serine transmembrane transporter activity|integral component of mitochondrial inner membrane|serine import into mitochondrion|mitochondrial transmembrane transport SFXN3 4154.691805 3356.459387 4952.924222 1.475639551 0.561340362 0.079080561 1 53.89753554 82.95930864 81855 sideroflexin 3 "GO:0005739,GO:0006730,GO:0022857,GO:0022889,GO:0031305,GO:0140300,GO:1990542" mitochondrion|one-carbon metabolic process|transmembrane transporter activity|serine transmembrane transporter activity|integral component of mitochondrial inner membrane|serine import into mitochondrion|mitochondrial transmembrane transport SFXN4 198.5859576 239.5296085 157.6423066 0.658132861 -0.603549236 0.264459232 1 6.077820472 4.172317732 119559 sideroflexin 4 "GO:0005739,GO:0006865,GO:0015075,GO:0022857,GO:0031305,GO:0034220,GO:1990542" mitochondrion|amino acid transport|ion transmembrane transporter activity|transmembrane transporter activity|integral component of mitochondrial inner membrane|ion transmembrane transport|mitochondrial transmembrane transport SFXN5 345.2579814 398.8776956 291.6382673 0.731147092 -0.451766418 0.318907752 1 3.866363277 2.948650805 94097 sideroflexin 5 "GO:0005515,GO:0005739,GO:0006865,GO:0015137,GO:0015746,GO:0022857,GO:0031305,GO:0034220,GO:1990542" protein binding|mitochondrion|amino acid transport|citrate transmembrane transporter activity|citrate transport|transmembrane transporter activity|integral component of mitochondrial inner membrane|ion transmembrane transport|mitochondrial transmembrane transport SGCB 1490.956456 1499.089965 1482.822947 0.989148738 -0.01574062 0.964347812 1 17.87279149 18.44038227 6443 sarcoglycan beta "GO:0005515,GO:0005737,GO:0005856,GO:0005887,GO:0007517,GO:0016010,GO:0016012,GO:0042383,GO:0048747,GO:0055013,GO:0097084" protein binding|cytoplasm|cytoskeleton|integral component of plasma membrane|muscle organ development|dystrophin-associated glycoprotein complex|sarcoglycan complex|sarcolemma|muscle fiber development|cardiac muscle cell development|vascular associated smooth muscle cell development "hsa05410,hsa05412,hsa05414,hsa05416" Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis SGCE 595.6796845 578.524902 612.8344671 1.059305252 0.08311838 0.835575126 1 6.535856652 7.221702169 8910 sarcoglycan epsilon "GO:0005794,GO:0005856,GO:0005886,GO:0005887,GO:0007160,GO:0007517,GO:0016010,GO:0016012,GO:0032590,GO:0042383" Golgi apparatus|cytoskeleton|plasma membrane|integral component of plasma membrane|cell-matrix adhesion|muscle organ development|dystrophin-associated glycoprotein complex|sarcoglycan complex|dendrite membrane|sarcolemma SGF29 157.1806038 170.5126027 143.8486048 0.843624474 -0.245327145 0.68034812 1 5.094903713 4.483333865 112869 SAGA complex associated factor 29 "GO:0000124,GO:0005515,GO:0005671,GO:0016573,GO:0019899,GO:0035064,GO:0043966,GO:0047485,GO:0070461,GO:0071169" SAGA complex|protein binding|Ada2/Gcn5/Ada3 transcription activator complex|histone acetylation|enzyme binding|methylated histone binding|histone H3 acetylation|protein N-terminus binding|SAGA-type complex|establishment of protein localization to chromatin SGK1 311.9601512 311.5914823 312.32882 1.00236636 0.003409904 1 1 4.19931063 4.390565033 6446 serum/glucocorticoid regulated kinase 1 "GO:0001558,GO:0004674,GO:0004712,GO:0005246,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005789,GO:0005829,GO:0005886,GO:0006468,GO:0006814,GO:0006915,GO:0006974,GO:0007616,GO:0008217,GO:0015459,GO:0016607,GO:0017080,GO:0017081,GO:0018105,GO:0030334,GO:0032411,GO:0034220,GO:0035556,GO:0042127,GO:0042981,GO:0048812,GO:0050790,GO:0051090,GO:0060453,GO:0070294,GO:0106310,GO:0106311,GO:1904045" regulation of cell growth|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|calcium channel regulator activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum membrane|cytosol|plasma membrane|protein phosphorylation|sodium ion transport|apoptotic process|cellular response to DNA damage stimulus|long-term memory|regulation of blood pressure|potassium channel regulator activity|nuclear speck|sodium channel regulator activity|chloride channel regulator activity|peptidyl-serine phosphorylation|regulation of cell migration|positive regulation of transporter activity|ion transmembrane transport|intracellular signal transduction|regulation of cell population proliferation|regulation of apoptotic process|neuron projection morphogenesis|regulation of catalytic activity|regulation of DNA-binding transcription factor activity|regulation of gastric acid secretion|renal sodium ion absorption|protein serine kinase activity|protein threonine kinase activity|cellular response to aldosterone "hsa04068,hsa04150,hsa04151,hsa04960" FoxO signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Aldosterone-regulated sodium reabsorption SGK3 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.012178142 0.049324486 23678 serum/glucocorticoid regulated kinase family member 3 "GO:0001558,GO:0004672,GO:0004674,GO:0005246,GO:0005515,GO:0005524,GO:0005654,GO:0005769,GO:0005829,GO:0006468,GO:0015459,GO:0017080,GO:0017081,GO:0018105,GO:0030334,GO:0034220,GO:0035091,GO:0035556,GO:0042127,GO:0043231,GO:0051090,GO:0055037,GO:0106310,GO:0106311" regulation of cell growth|protein kinase activity|protein serine/threonine kinase activity|calcium channel regulator activity|protein binding|ATP binding|nucleoplasm|early endosome|cytosol|protein phosphorylation|potassium channel regulator activity|sodium channel regulator activity|chloride channel regulator activity|peptidyl-serine phosphorylation|regulation of cell migration|ion transmembrane transport|phosphatidylinositol binding|intracellular signal transduction|regulation of cell population proliferation|intracellular membrane-bounded organelle|regulation of DNA-binding transcription factor activity|recycling endosome|protein serine kinase activity|protein threonine kinase activity "hsa04068,hsa04151" FoxO signaling pathway|PI3K-Akt signaling pathway SGMS1 540.4509373 507.4779842 573.4238904 1.12994831 0.176256777 0.662596779 1 2.391770857 2.818993512 259230 sphingomyelin synthase 1 "GO:0000138,GO:0000139,GO:0002950,GO:0005634,GO:0005783,GO:0005886,GO:0005887,GO:0006686,GO:0006915,GO:0006954,GO:0010628,GO:0016020,GO:0016301,GO:0016310,GO:0030148,GO:0030173,GO:0030176,GO:0033188,GO:0046513,GO:0047493,GO:0071222,GO:0071356,GO:2001242" Golgi trans cisterna|Golgi membrane|ceramide phosphoethanolamine synthase activity|nucleus|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|sphingomyelin biosynthetic process|apoptotic process|inflammatory response|positive regulation of gene expression|membrane|kinase activity|phosphorylation|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|sphingomyelin synthase activity|ceramide biosynthetic process|ceramide cholinephosphotransferase activity|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|regulation of intrinsic apoptotic signaling pathway "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SGMS2 427.1779426 476.0143492 378.341536 0.7948112 -0.331315893 0.437534442 1 3.115188979 2.582642572 166929 sphingomyelin synthase 2 "GO:0002950,GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0006686,GO:0016301,GO:0016310,GO:0030148,GO:0030173,GO:0030176,GO:0030500,GO:0033188,GO:0046513,GO:0047493,GO:1905373" ceramide phosphoethanolamine synthase activity|protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|sphingomyelin biosynthetic process|kinase activity|phosphorylation|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|regulation of bone mineralization|sphingomyelin synthase activity|ceramide biosynthetic process|ceramide cholinephosphotransferase activity|ceramide phosphoethanolamine biosynthetic process "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SGO1 592.6496624 573.4501221 611.8492027 1.0669615 0.09350812 0.815008223 1 5.00141651 5.566185838 151648 shugoshin 1 "GO:0000070,GO:0000775,GO:0000776,GO:0000777,GO:0000779,GO:0000922,GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0007059,GO:0008608,GO:0010457,GO:0019900,GO:0045132,GO:0045143,GO:0051177,GO:0051301,GO:0071962" "mitotic sister chromatid segregation|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed chromosome, centromeric region|spindle pole|protein binding|nucleoplasm|centrosome|cytosol|chromosome segregation|attachment of spindle microtubules to kinetochore|centriole-centriole cohesion|kinase binding|meiotic chromosome segregation|homologous chromosome segregation|meiotic sister chromatid cohesion|cell division|mitotic sister chromatid cohesion, centromeric" hsa04114 Oocyte meiosis SGO2 475.4531774 509.5078961 441.3984586 0.866323097 -0.207022913 0.619267471 1 4.168111372 3.766475423 151246 shugoshin 2 "GO:0000070,GO:0000775,GO:0000776,GO:0000777,GO:0005515,GO:0005654,GO:0005829,GO:0016604,GO:0030892,GO:0045143,GO:0051177,GO:0051301,GO:0051754" "mitotic sister chromatid segregation|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|protein binding|nucleoplasm|cytosol|nuclear body|mitotic cohesin complex|homologous chromosome segregation|meiotic sister chromatid cohesion|cell division|meiotic sister chromatid cohesion, centromeric" SGPL1 2003.219478 1864.474114 2141.964842 1.148830561 0.200166033 0.534850102 1 18.61771222 22.30993078 8879 sphingosine-1-phosphate lyase 1 "GO:0001553,GO:0001570,GO:0001667,GO:0001822,GO:0005515,GO:0005783,GO:0005789,GO:0006631,GO:0006672,GO:0007283,GO:0008117,GO:0008209,GO:0008210,GO:0009791,GO:0010761,GO:0016831,GO:0030097,GO:0030148,GO:0030149,GO:0030170,GO:0030176,GO:0033327,GO:0040014,GO:0048008,GO:0048705,GO:0060021,GO:0060325,GO:0097190" luteinization|vasculogenesis|ameboidal-type cell migration|kidney development|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|ceramide metabolic process|spermatogenesis|sphinganine-1-phosphate aldolase activity|androgen metabolic process|estrogen metabolic process|post-embryonic development|fibroblast migration|carboxy-lyase activity|hemopoiesis|sphingolipid biosynthetic process|sphingolipid catabolic process|pyridoxal phosphate binding|integral component of endoplasmic reticulum membrane|Leydig cell differentiation|regulation of multicellular organism growth|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|roof of mouth development|face morphogenesis|apoptotic signaling pathway "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SGPP1 772.2713827 695.2448383 849.2979271 1.221581061 0.2887496 0.435769805 1 10.19446971 12.98981185 81537 sphingosine-1-phosphate phosphatase 1 "GO:0005789,GO:0005886,GO:0006668,GO:0006670,GO:0016020,GO:0016021,GO:0030148,GO:0035621,GO:0042392,GO:0045616,GO:0045682,GO:0046839,GO:0097191,GO:0097193" endoplasmic reticulum membrane|plasma membrane|sphinganine-1-phosphate metabolic process|sphingosine metabolic process|membrane|integral component of membrane|sphingolipid biosynthetic process|ER to Golgi ceramide transport|sphingosine-1-phosphate phosphatase activity|regulation of keratinocyte differentiation|regulation of epidermis development|phospholipid dephosphorylation|extrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SGPP2 1041.154796 1665.542744 416.7668482 0.250228852 -1.998679952 3.69E-08 2.17E-05 15.9428963 4.161218626 130367 sphingosine-1-phosphate phosphatase 2 "GO:0005783,GO:0005789,GO:0006670,GO:0016020,GO:0016021,GO:0030148,GO:0042392,GO:0046839,GO:0061469" endoplasmic reticulum|endoplasmic reticulum membrane|sphingosine metabolic process|membrane|integral component of membrane|sphingolipid biosynthetic process|sphingosine-1-phosphate phosphatase activity|phospholipid dephosphorylation|regulation of type B pancreatic cell proliferation "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SGSH 992.4683311 997.7017169 987.2349454 0.989509117 -0.015215094 0.968728311 1 12.61044978 13.01566335 6448 N-sulfoglucosamine sulfohydrolase "GO:0005539,GO:0005764,GO:0006027,GO:0008449,GO:0016250,GO:0030200,GO:0043202,GO:0046872,GO:0070062" glycosaminoglycan binding|lysosome|glycosaminoglycan catabolic process|N-acetylglucosamine-6-sulfatase activity|N-sulfoglucosamine sulfohydrolase activity|heparan sulfate proteoglycan catabolic process|lysosomal lumen|metal ion binding|extracellular exosome "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome SGSM2 1417.903875 1421.953312 1413.854438 0.994304402 -0.0082405 0.982674121 1 10.2253186 10.60503584 9905 small G protein signaling modulator 2 "GO:0005096,GO:0005737,GO:0006886,GO:0031267,GO:0034499,GO:0042470,GO:0043547,GO:0090630" GTPase activator activity|cytoplasm|intracellular protein transport|small GTPase binding|late endosome to Golgi transport|melanosome|positive regulation of GTPase activity|activation of GTPase activity SGSM3 745.3817305 742.9477688 747.8156922 1.006552174 0.009421956 0.983875579 1 11.91503595 12.50971968 27352 small G protein signaling modulator 3 "GO:0005096,GO:0005515,GO:0005829,GO:0005921,GO:0006886,GO:0007050,GO:0031267,GO:0032483,GO:0032486,GO:0043547,GO:0045732,GO:0048227,GO:0090630,GO:1902017" GTPase activator activity|protein binding|cytosol|gap junction|intracellular protein transport|cell cycle arrest|small GTPase binding|regulation of Rab protein signal transduction|Rap protein signal transduction|positive regulation of GTPase activity|positive regulation of protein catabolic process|plasma membrane to endosome transport|activation of GTPase activity|regulation of cilium assembly SGTA 1689.839329 1758.918693 1620.759965 0.921452465 -0.118018352 0.719250148 1 36.9639115 35.52767502 6449 small glutamine rich tetratricopeptide repeat co-chaperone alpha "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006620,GO:0016020,GO:0016032,GO:0030433,GO:0042802,GO:0043621,GO:0060090,GO:0071816,GO:0072380,GO:1903070,GO:1903071,GO:1903646,GO:1904288,GO:2000059" protein binding|nucleus|cytoplasm|cytosol|posttranslational protein targeting to endoplasmic reticulum membrane|membrane|viral process|ubiquitin-dependent ERAD pathway|identical protein binding|protein self-association|molecular adaptor activity|tail-anchored membrane protein insertion into ER membrane|TRC complex|negative regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of chaperone-mediated protein folding|BAT3 complex binding|negative regulation of ubiquitin-dependent protein catabolic process SGTB 497.2356366 483.1190409 511.3522322 1.058439409 0.081938684 0.845586285 1 4.351462757 4.804157116 54557 small glutamine rich tetratricopeptide repeat co-chaperone beta "GO:0005515,GO:0006620,GO:0016020,GO:0030433,GO:0060090,GO:0072380,GO:1903646" protein binding|posttranslational protein targeting to endoplasmic reticulum membrane|membrane|ubiquitin-dependent ERAD pathway|molecular adaptor activity|TRC complex|positive regulation of chaperone-mediated protein folding SH2B1 448.3099092 371.4738844 525.145934 1.413681973 0.499457603 0.234949418 1 5.564579049 8.20540395 25970 SH2B adaptor protein 1 "GO:0005068,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0007169,GO:0007596,GO:0030032,GO:0035556,GO:0045840,GO:0060391,GO:2000278" transmembrane receptor protein tyrosine kinase adaptor activity|protein binding|nucleus|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|blood coagulation|lamellipodium assembly|intracellular signal transduction|positive regulation of mitotic nuclear division|positive regulation of SMAD protein signal transduction|regulation of DNA biosynthetic process hsa04722 Neurotrophin signaling pathway SH2B2 245.0985044 287.232539 202.9644698 0.706620742 -0.500991997 0.3214005 1 4.813803709 3.548057817 10603 SH2B adaptor protein 2 "GO:0005068,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007596,GO:0008286,GO:0035556,GO:0035591,GO:0042169,GO:0050851,GO:0050853" transmembrane receptor protein tyrosine kinase adaptor activity|protein binding|cytoplasm|cytosol|plasma membrane|blood coagulation|insulin receptor signaling pathway|intracellular signal transduction|signaling adaptor activity|SH2 domain binding|antigen receptor-mediated signaling pathway|B cell receptor signaling pathway "hsa04722,hsa04910" Neurotrophin signaling pathway|Insulin signaling pathway SH2B3 7072.827032 6406.402072 7739.251992 1.208049683 0.272679789 0.40556109 1 43.20395 54.44076011 10019 SH2B adaptor protein 3 "GO:0001780,GO:0005068,GO:0005173,GO:0005515,GO:0005829,GO:0005886,GO:0007169,GO:0007596,GO:0008285,GO:0030159,GO:0035162,GO:0035556,GO:0035702,GO:0035855,GO:0036016,GO:0038163,GO:0042532,GO:0043407,GO:0046426,GO:0048821,GO:0051898,GO:0060761,GO:0070100,GO:0090331,GO:1900235,GO:1990782,GO:1990869" neutrophil homeostasis|transmembrane receptor protein tyrosine kinase adaptor activity|stem cell factor receptor binding|protein binding|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|blood coagulation|negative regulation of cell population proliferation|signaling receptor complex adaptor activity|embryonic hemopoiesis|intracellular signal transduction|monocyte homeostasis|megakaryocyte development|cellular response to interleukin-3|thrombopoietin-mediated signaling pathway|negative regulation of tyrosine phosphorylation of STAT protein|negative regulation of MAP kinase activity|negative regulation of receptor signaling pathway via JAK-STAT|erythrocyte development|negative regulation of protein kinase B signaling|negative regulation of response to cytokine stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of platelet aggregation|negative regulation of Kit signaling pathway|protein tyrosine kinase binding|cellular response to chemokine hsa04722 Neurotrophin signaling pathway SH2D2A 118.4677786 218.2155332 18.72002391 0.085786853 -3.543099617 1.02E-06 0.000430109 6.254582308 0.559673803 9047 SH2 domain containing 2A "GO:0001525,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0008283,GO:0017124,GO:0030154,GO:0048010" angiogenesis|protein binding|cytoplasm|cytosol|signal transduction|cell population proliferation|SH3 domain binding|cell differentiation|vascular endothelial growth factor receptor signaling pathway hsa04370 VEGF signaling pathway SH2D3A 84.19012708 63.94222601 104.4380282 1.633318617 0.70780625 0.325856482 1 1.062482996 1.8101261 10045 SH2 domain containing 3A "GO:0001784,GO:0005085,GO:0005515,GO:0007254,GO:0007264,GO:0033138,GO:0050790" phosphotyrosine residue binding|guanyl-nucleotide exchange factor activity|protein binding|JNK cascade|small GTPase mediated signal transduction|positive regulation of peptidyl-serine phosphorylation|regulation of catalytic activity SH2D4A 408.5645607 449.625494 367.5036274 0.817354959 -0.29096535 0.501258056 1 6.775348137 5.77641314 63898 SH2 domain containing 4A "GO:0005515,GO:0005737,GO:0005829,GO:0010923,GO:0019902" protein binding|cytoplasm|cytosol|negative regulation of phosphatase activity|phosphatase binding SH2D5 73.21588491 88.30116925 58.13060058 0.65832198 -0.603134728 0.425471352 1 0.909896788 0.624807764 400745 SH2 domain containing 5 GO:0014069 postsynaptic density SH2D6 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.036975931 0.037440414 284948 SH2 domain containing 6 "GO:0005737,GO:0007169,GO:0035556" cytoplasm|transmembrane receptor protein tyrosine kinase signaling pathway|intracellular signal transduction SH3BGRL 1491.67994 1413.833664 1569.526216 1.110120841 0.150716728 0.650552012 1 31.57217256 36.55869237 6451 SH3 domain binding glutamate rich protein like "GO:0005615,GO:0005634,GO:0005737,GO:0017124,GO:0070062" extracellular space|nucleus|cytoplasm|SH3 domain binding|extracellular exosome SH3BGRL2 149.1972896 129.914364 168.4802152 1.296855945 0.375018234 0.531276551 1 1.320430308 1.786171482 83699 SH3 domain binding glutamate rich protein like 2 "GO:0005654,GO:0017124,GO:0031965" nucleoplasm|SH3 domain binding|nuclear membrane SH3BGRL3 3376.5462 3303.681677 3449.410722 1.044111104 0.062275237 0.845514363 1 222.796035 242.6443044 83442 SH3 domain binding glutamate rich protein like 3 "GO:0005515,GO:0005737,GO:0015035,GO:0016604,GO:0055114,GO:0070062" protein binding|cytoplasm|protein disulfide oxidoreductase activity|nuclear body|oxidation-reduction process|extracellular exosome SH3BP1 714.6104037 794.7105232 634.5102843 0.798416865 -0.3247859 0.388183283 1 15.14269542 12.61097947 23616 SH3 domain binding protein 1 "GO:0000145,GO:0001891,GO:0005096,GO:0005515,GO:0005622,GO:0005634,GO:0005829,GO:0005912,GO:0005923,GO:0006911,GO:0007015,GO:0016477,GO:0017124,GO:0030027,GO:0030215,GO:0030834,GO:0031252,GO:0032956,GO:0034329,GO:0035020,GO:0043535,GO:0043547,GO:0045198,GO:0046847,GO:0051058,GO:0071526,GO:0097178" "exocyst|phagocytic cup|GTPase activator activity|protein binding|intracellular anatomical structure|nucleus|cytosol|adherens junction|bicellular tight junction|phagocytosis, engulfment|actin filament organization|cell migration|SH3 domain binding|lamellipodium|semaphorin receptor binding|regulation of actin filament depolymerization|cell leading edge|regulation of actin cytoskeleton organization|cell junction assembly|regulation of Rac protein signal transduction|regulation of blood vessel endothelial cell migration|positive regulation of GTPase activity|establishment of epithelial cell apical/basal polarity|filopodium assembly|negative regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway|ruffle assembly" SH3BP2 857.7288439 778.4712277 936.9864601 1.203623752 0.267384482 0.461269446 1 4.076809162 5.118315602 6452 SH3 domain binding protein 2 "GO:0001784,GO:0005515,GO:0007165,GO:0017124" phosphotyrosine residue binding|protein binding|signal transduction|SH3 domain binding hsa04650 Natural killer cell mediated cytotoxicity SH3BP4 1862.534507 1878.683497 1846.385517 0.982808184 -0.025018223 0.940166323 1 14.91592594 15.29096564 23677 SH3 domain binding protein 4 "GO:0005092,GO:0005515,GO:0005634,GO:0005737,GO:0005905,GO:0006897,GO:0008285,GO:0010508,GO:0030136,GO:0030308,GO:0031267,GO:0032007,GO:0034260,GO:0042802,GO:0043090,GO:0050790,GO:0061462,GO:0070062,GO:0071230" GDP-dissociation inhibitor activity|protein binding|nucleus|cytoplasm|clathrin-coated pit|endocytosis|negative regulation of cell population proliferation|positive regulation of autophagy|clathrin-coated vesicle|negative regulation of cell growth|small GTPase binding|negative regulation of TOR signaling|negative regulation of GTPase activity|identical protein binding|amino acid import|regulation of catalytic activity|protein localization to lysosome|extracellular exosome|cellular response to amino acid stimulus SH3BP5 667.2989066 658.7064235 675.8913898 1.026088961 0.037155817 0.926451956 1 8.636074702 9.24309327 9467 SH3 domain binding protein 5 "GO:0004860,GO:0005085,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0007165,GO:0016604,GO:0017124,GO:0030659,GO:0035556,GO:0061099" protein kinase inhibitor activity|guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|signal transduction|nuclear body|SH3 domain binding|cytoplasmic vesicle membrane|intracellular signal transduction|negative regulation of protein tyrosine kinase activity SH3BP5L 1145.366424 1144.870332 1145.862516 1.000866634 0.001249748 1 1 12.70735119 13.26621935 80851 SH3 binding domain protein 5 like "GO:0004860,GO:0005085,GO:0005515,GO:0005737,GO:0035556,GO:0061099" protein kinase inhibitor activity|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|intracellular signal transduction|negative regulation of protein tyrosine kinase activity SH3D19 470.7144072 589.6894176 351.7393967 0.596482464 -0.745448371 0.072954815 1 3.646159041 2.268554504 152503 SH3 domain containing 19 "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0007010,GO:0022604,GO:0051044" protein binding|nucleoplasm|cytosol|plasma membrane|cytoskeleton organization|regulation of cell morphogenesis|positive regulation of membrane protein ectodomain proteolysis SH3D21 236.8425231 295.3521868 178.3328594 0.603797322 -0.727863737 0.154121138 1 5.246771772 3.304450765 79729 SH3 domain containing 21 "GO:0005654,GO:0005886" nucleoplasm|plasma membrane SH3GL1 1739.620668 1996.41839 1482.822947 0.742741579 -0.429067752 0.188436023 1 38.38707232 29.73984202 6455 "SH3 domain containing GRB2 like 1, endophilin A2" "GO:0002102,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0007417,GO:0008022,GO:0008289,GO:0016191,GO:0017124,GO:0019902,GO:0031697,GO:0031901,GO:0042802,GO:0042995,GO:0044325,GO:0045296,GO:0051020,GO:0098685,GO:0098686,GO:0098793,GO:0098815,GO:0098978,GO:0099092,GO:1900244" "podosome|protein binding|cytoplasm|cytosol|signal transduction|central nervous system development|protein C-terminus binding|lipid binding|synaptic vesicle uncoating|SH3 domain binding|phosphatase binding|beta-1 adrenergic receptor binding|early endosome membrane|identical protein binding|cell projection|ion channel binding|cadherin binding|GTPase binding|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|presynapse|modulation of excitatory postsynaptic potential|glutamatergic synapse|postsynaptic density, intracellular component|positive regulation of synaptic vesicle endocytosis" hsa04144 Endocytosis SH3GL3 17.01671905 18.26920743 15.76423066 0.862885307 -0.212759283 0.904944967 1 0.131299973 0.118177185 6457 "SH3 domain containing GRB2 like 3, endophilin A3" "GO:0001669,GO:0005515,GO:0006897,GO:0007165,GO:0007417,GO:0008022,GO:0008289,GO:0031901,GO:0042802,GO:0045666,GO:0098793,GO:0098845,GO:0098978,GO:0099092,GO:1900186" "acrosomal vesicle|protein binding|endocytosis|signal transduction|central nervous system development|protein C-terminus binding|lipid binding|early endosome membrane|identical protein binding|positive regulation of neuron differentiation|presynapse|postsynaptic endosome|glutamatergic synapse|postsynaptic density, intracellular component|negative regulation of clathrin-dependent endocytosis" hsa04144 Endocytosis SH3GLB1 2201.555779 2053.255924 2349.855633 1.144453356 0.194658665 0.543878297 1 14.86635727 17.74674023 51100 "SH3 domain containing GRB2 like, endophilin B1" "GO:0000139,GO:0000421,GO:0005515,GO:0005737,GO:0005741,GO:0005829,GO:0006914,GO:0006915,GO:0008289,GO:0010508,GO:0016241,GO:0030496,GO:0031334,GO:0031410,GO:0031647,GO:0032465,GO:0032801,GO:0032991,GO:0034198,GO:0042149,GO:0042802,GO:0042803,GO:0045296,GO:0048102,GO:0090148,GO:1903527,GO:1903778,GO:1903955,GO:2000786" Golgi membrane|autophagosome membrane|protein binding|cytoplasm|mitochondrial outer membrane|cytosol|autophagy|apoptotic process|lipid binding|positive regulation of autophagy|regulation of macroautophagy|midbody|positive regulation of protein-containing complex assembly|cytoplasmic vesicle|regulation of protein stability|regulation of cytokinesis|receptor catabolic process|protein-containing complex|cellular response to amino acid starvation|cellular response to glucose starvation|identical protein binding|protein homodimerization activity|cadherin binding|autophagic cell death|membrane fission|positive regulation of membrane tubulation|protein localization to vacuolar membrane|positive regulation of protein targeting to mitochondrion|positive regulation of autophagosome assembly "hsa04140,hsa04144" Autophagy - animal|Endocytosis SH3GLB2 1303.177478 1089.047754 1517.307201 1.39324212 0.478445994 0.157009278 1 15.45430844 22.45908717 56904 "SH3 domain containing GRB2 like, endophilin B2" "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0042802,GO:0045296" protein binding|nucleoplasm|cytoplasm|cytosol|identical protein binding|cadherin binding hsa04144 Endocytosis SH3KBP1 4375.633025 4787.547303 3963.718748 0.827922629 -0.272432144 0.393890238 1 44.35199953 38.30177375 30011 SH3 domain containing kinase binding protein 1 "GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0005925,GO:0006897,GO:0006915,GO:0007010,GO:0007015,GO:0007267,GO:0007411,GO:0008360,GO:0016477,GO:0017124,GO:0030139,GO:0030659,GO:0042059,GO:0043005,GO:0045202,GO:0050871,GO:0061024" protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|cell-cell junction|focal adhesion|endocytosis|apoptotic process|cytoskeleton organization|actin filament organization|cell-cell signaling|axon guidance|regulation of cell shape|cell migration|SH3 domain binding|endocytic vesicle|cytoplasmic vesicle membrane|negative regulation of epidermal growth factor receptor signaling pathway|neuron projection|synapse|positive regulation of B cell activation|membrane organization hsa04144 Endocytosis SH3PXD2A 1605.608378 2197.379672 1013.837085 0.461384574 -1.115958324 0.000782412 0.079140395 9.564242736 4.602879336 9644 SH3 and PX domains 2A "GO:0001701,GO:0002020,GO:0002102,GO:0005515,GO:0005546,GO:0005737,GO:0005829,GO:0006801,GO:0010314,GO:0016176,GO:0030054,GO:0030198,GO:0032266,GO:0042995,GO:0043325,GO:0050790,GO:0070273,GO:0072675" "in utero embryonic development|protease binding|podosome|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|superoxide metabolic process|phosphatidylinositol-5-phosphate binding|superoxide-generating NADPH oxidase activator activity|cell junction|extracellular matrix organization|phosphatidylinositol-3-phosphate binding|cell projection|phosphatidylinositol-3,4-bisphosphate binding|regulation of catalytic activity|phosphatidylinositol-4-phosphate binding|osteoclast fusion" SH3PXD2B 2021.641102 2046.151232 1997.130972 0.9760427 -0.034983831 0.914986079 1 12.85576746 13.08828537 285590 SH3 and PX domains 2B "GO:0001501,GO:0001654,GO:0002102,GO:0005515,GO:0005737,GO:0006801,GO:0007507,GO:0010314,GO:0016176,GO:0022617,GO:0030054,GO:0030154,GO:0032266,GO:0042169,GO:0042995,GO:0050790,GO:0060348,GO:0060612,GO:0070273,GO:0071800,GO:0072657,GO:0080025" "skeletal system development|eye development|podosome|protein binding|cytoplasm|superoxide metabolic process|heart development|phosphatidylinositol-5-phosphate binding|superoxide-generating NADPH oxidase activator activity|extracellular matrix disassembly|cell junction|cell differentiation|phosphatidylinositol-3-phosphate binding|SH2 domain binding|cell projection|regulation of catalytic activity|bone development|adipose tissue development|phosphatidylinositol-4-phosphate binding|podosome assembly|protein localization to membrane|phosphatidylinositol-3,5-bisphosphate binding" SH3RF1 792.2614624 681.0354548 903.48747 1.326637936 0.407774686 0.268127224 1 6.736727194 9.322176098 57630 SH3 domain containing ring finger 1 "GO:0001764,GO:0005078,GO:0005515,GO:0005794,GO:0005829,GO:0016032,GO:0030027,GO:0043066,GO:0043154,GO:0043370,GO:0046330,GO:0046872,GO:0048471,GO:0051865,GO:0061630,GO:2000564,GO:2001237" "neuron migration|MAP-kinase scaffold activity|protein binding|Golgi apparatus|cytosol|viral process|lamellipodium|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of JNK cascade|metal ion binding|perinuclear region of cytoplasm|protein autoubiquitination|ubiquitin protein ligase activity|regulation of CD8-positive, alpha-beta T cell proliferation|negative regulation of extrinsic apoptotic signaling pathway" SH3RF2 504.1985516 588.6744617 419.7226414 0.712996178 -0.488033751 0.23152488 1 4.710741786 3.503421826 153769 SH3 domain containing ring finger 2 "GO:0004864,GO:0005515,GO:0005634,GO:0005654,GO:0008157,GO:0010923,GO:0019902,GO:0030335,GO:0031397,GO:0032436,GO:0032515,GO:0043066,GO:0046329,GO:0046330,GO:0046872,GO:0051865,GO:0061630" protein phosphatase inhibitor activity|protein binding|nucleus|nucleoplasm|protein phosphatase 1 binding|negative regulation of phosphatase activity|phosphatase binding|positive regulation of cell migration|negative regulation of protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of phosphoprotein phosphatase activity|negative regulation of apoptotic process|negative regulation of JNK cascade|positive regulation of JNK cascade|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity SH3RF3 417.688278 601.8688892 233.5076667 0.387970987 -1.365979327 0.001673346 0.126706878 2.781507069 1.12562919 344558 SH3 domain containing ring finger 3 "GO:0005515,GO:0006915,GO:0046330,GO:0046872,GO:0051865,GO:0061630" protein binding|apoptotic process|positive regulation of JNK cascade|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity SH3TC1 115.9858124 82.21143344 149.7601913 1.821646759 0.865243229 0.181003425 1 0.662169065 1.258197978 54436 SH3 domain and tetratricopeptide repeats 1 "GO:0005575,GO:0008150" cellular_component|biological_process SH3TC2 292.5369326 330.8756457 254.1982195 0.768259081 -0.38033518 0.42622404 1 0.633129976 0.507360331 79628 SH3 domain and tetratricopeptide repeats 2 "GO:0005886,GO:0031410,GO:0032287,GO:0033157,GO:1901184" plasma membrane|cytoplasmic vesicle|peripheral nervous system myelin maintenance|regulation of intracellular protein transport|regulation of ERBB signaling pathway SH3YL1 48.06467234 52.77771036 43.35163433 0.821400437 -0.283842381 0.758160811 1 1.300732283 1.114445354 26751 SH3 and SYLF domain containing 1 "GO:0005515,GO:0006661,GO:0019902,GO:0032587,GO:0035091" protein binding|phosphatidylinositol biosynthetic process|phosphatase binding|ruffle membrane|phosphatidylinositol binding SHANK1 575.9810772 680.0204988 471.9416555 0.694010925 -0.526969721 0.182044117 1 3.573792601 2.587090268 50944 SH3 and multiple ankyrin repeat domains 1 "GO:0005515,GO:0005829,GO:0005886,GO:0007610,GO:0007616,GO:0008022,GO:0008306,GO:0008328,GO:0014069,GO:0016020,GO:0017124,GO:0017146,GO:0030160,GO:0030425,GO:0030534,GO:0031877,GO:0032232,GO:0035176,GO:0035255,GO:0035418,GO:0042802,GO:0043005,GO:0043197,GO:0044877,GO:0045211,GO:0048854,GO:0050885,GO:0050894,GO:0051124,GO:0051968,GO:0060074,GO:0060076,GO:0060291,GO:0060997,GO:0060999,GO:0065003,GO:0071532,GO:0071625,GO:0097107,GO:0097110,GO:2000311,GO:2000463" "protein binding|cytosol|plasma membrane|behavior|long-term memory|protein C-terminus binding|associative learning|ionotropic glutamate receptor complex|postsynaptic density|membrane|SH3 domain binding|NMDA selective glutamate receptor complex|synaptic receptor adaptor activity|dendrite|adult behavior|somatostatin receptor binding|negative regulation of actin filament bundle assembly|social behavior|ionotropic glutamate receptor binding|protein localization to synapse|identical protein binding|neuron projection|dendritic spine|protein-containing complex binding|postsynaptic membrane|brain morphogenesis|neuromuscular process controlling balance|determination of affect|synaptic growth at neuromuscular junction|positive regulation of synaptic transmission, glutamatergic|synapse maturation|excitatory synapse|long-term synaptic potentiation|dendritic spine morphogenesis|positive regulation of dendritic spine development|protein-containing complex assembly|ankyrin repeat binding|vocalization behavior|postsynaptic density assembly|scaffold protein binding|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential" hsa04724 Glutamatergic synapse SHANK2 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.010445124 0.010576334 22941 SH3 and multiple ankyrin repeat domains 2 "GO:0001750,GO:0001917,GO:0005515,GO:0005575,GO:0005829,GO:0005883,GO:0005886,GO:0007416,GO:0007610,GO:0007612,GO:0008284,GO:0008328,GO:0014069,GO:0016324,GO:0017124,GO:0030160,GO:0030426,GO:0030534,GO:0031526,GO:0035176,GO:0035255,GO:0035331,GO:0043005,GO:0043025,GO:0043197,GO:0045211,GO:0048854,GO:0051124,GO:0051968,GO:0060170,GO:0060291,GO:0060292,GO:0060997,GO:0060999,GO:0071625,GO:0097107,GO:2000311,GO:2000463" "photoreceptor outer segment|photoreceptor inner segment|protein binding|cellular_component|cytosol|neurofilament|plasma membrane|synapse assembly|behavior|learning|positive regulation of cell population proliferation|ionotropic glutamate receptor complex|postsynaptic density|apical plasma membrane|SH3 domain binding|synaptic receptor adaptor activity|growth cone|adult behavior|brush border membrane|social behavior|ionotropic glutamate receptor binding|negative regulation of hippo signaling|neuron projection|neuronal cell body|dendritic spine|postsynaptic membrane|brain morphogenesis|synaptic growth at neuromuscular junction|positive regulation of synaptic transmission, glutamatergic|ciliary membrane|long-term synaptic potentiation|long-term synaptic depression|dendritic spine morphogenesis|positive regulation of dendritic spine development|vocalization behavior|postsynaptic density assembly|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential" hsa04724 Glutamatergic synapse SHANK3 467.7128388 418.161859 517.2638187 1.236994259 0.306838804 0.461537381 1 2.767697722 3.571102123 85358 SH3 and multiple ankyrin repeat domains 3 "GO:0000165,GO:0003779,GO:0005515,GO:0005829,GO:0007411,GO:0007416,GO:0007610,GO:0007612,GO:0007613,GO:0008022,GO:0008270,GO:0008328,GO:0014069,GO:0017124,GO:0021773,GO:0030160,GO:0030534,GO:0031234,GO:0032232,GO:0035176,GO:0035255,GO:0042297,GO:0043005,GO:0043197,GO:0043621,GO:0044309,GO:0045211,GO:0045794,GO:0048170,GO:0048854,GO:0051124,GO:0051835,GO:0051968,GO:0060170,GO:0060291,GO:0060997,GO:0060999,GO:0061001,GO:0071625,GO:0097107,GO:0097110,GO:0097113,GO:0097114,GO:0097117,GO:1900271,GO:1900273,GO:1900451,GO:1900452,GO:2000311,GO:2000463,GO:2000969" "MAPK cascade|actin binding|protein binding|cytosol|axon guidance|synapse assembly|behavior|learning|memory|protein C-terminus binding|zinc ion binding|ionotropic glutamate receptor complex|postsynaptic density|SH3 domain binding|striatal medium spiny neuron differentiation|synaptic receptor adaptor activity|adult behavior|extrinsic component of cytoplasmic side of plasma membrane|negative regulation of actin filament bundle assembly|social behavior|ionotropic glutamate receptor binding|vocal learning|neuron projection|dendritic spine|protein self-association|neuron spine|postsynaptic membrane|negative regulation of cell volume|positive regulation of long-term neuronal synaptic plasticity|brain morphogenesis|synaptic growth at neuromuscular junction|positive regulation of synapse structural plasticity|positive regulation of synaptic transmission, glutamatergic|ciliary membrane|long-term synaptic potentiation|dendritic spine morphogenesis|positive regulation of dendritic spine development|regulation of dendritic spine morphogenesis|vocalization behavior|postsynaptic density assembly|scaffold protein binding|AMPA glutamate receptor clustering|NMDA glutamate receptor clustering|guanylate kinase-associated protein clustering|regulation of long-term synaptic potentiation|positive regulation of long-term synaptic potentiation|positive regulation of glutamate receptor signaling pathway|regulation of long-term synaptic depression|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of AMPA receptor activity" hsa04724 Glutamatergic synapse SHARPIN 1664.620815 1449.357123 1879.884507 1.297047137 0.375230911 0.25214317 1 54.45461814 73.6726694 81858 SHANK associated RH domain interactor "GO:0000151,GO:0004842,GO:0005515,GO:0005829,GO:0007005,GO:0007249,GO:0007420,GO:0010803,GO:0014069,GO:0030262,GO:0030425,GO:0031424,GO:0031593,GO:0042802,GO:0043123,GO:0043130,GO:0043161,GO:0044877,GO:0046872,GO:0050728,GO:0071797,GO:0097039,GO:2000348" ubiquitin ligase complex|ubiquitin-protein transferase activity|protein binding|cytosol|mitochondrion organization|I-kappaB kinase/NF-kappaB signaling|brain development|regulation of tumor necrosis factor-mediated signaling pathway|postsynaptic density|apoptotic nuclear changes|dendrite|keratinization|polyubiquitin modification-dependent protein binding|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|metal ion binding|negative regulation of inflammatory response|LUBAC complex|protein linear polyubiquitination|regulation of CD40 signaling pathway "hsa04217,hsa04621,hsa05131" Necroptosis|NOD-like receptor signaling pathway|Shigellosis SHB 1003.809512 1234.186458 773.432567 0.626674002 -0.674212951 0.056037197 1 10.35744658 6.770337367 6461 SH2 domain containing adaptor protein B "GO:0001525,GO:0001784,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006915,GO:0007165,GO:0030154,GO:0036464,GO:0048010" angiogenesis|phosphotyrosine residue binding|protein binding|nucleoplasm|cytosol|plasma membrane|apoptotic process|signal transduction|cell differentiation|cytoplasmic ribonucleoprotein granule|vascular endothelial growth factor receptor signaling pathway SHBG 10.46404258 8.119647747 12.80843742 1.577462202 0.657605437 0.673951806 1 0.22014535 0.362229994 6462 sex hormone binding globulin "GO:0005496,GO:0005497,GO:0005515,GO:0005576,GO:0070062" steroid binding|androgen binding|protein binding|extracellular region|extracellular exosome SHC1 6953.787695 7159.499401 6748.075989 0.942534612 -0.085382497 0.79449856 1 107.183975 105.3763366 6464 SHC adaptor protein 1 "GO:0000165,GO:0000187,GO:0001525,GO:0001784,GO:0005068,GO:0005154,GO:0005158,GO:0005159,GO:0005168,GO:0005515,GO:0005543,GO:0005759,GO:0005829,GO:0005886,GO:0007169,GO:0007173,GO:0007176,GO:0007265,GO:0007411,GO:0007507,GO:0008284,GO:0008286,GO:0016032,GO:0019221,GO:0019901,GO:0030971,GO:0031532,GO:0035723,GO:0036498,GO:0038095,GO:0038110,GO:0038128,GO:0040008,GO:0042742,GO:0043066,GO:0043410,GO:0045892,GO:0045893,GO:0046579,GO:0046875,GO:0048408,GO:0050900,GO:0070374,GO:0070435,GO:0071363,GO:0098609" "MAPK cascade|activation of MAPK activity|angiogenesis|phosphotyrosine residue binding|transmembrane receptor protein tyrosine kinase adaptor activity|epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|neurotrophin TRKA receptor binding|protein binding|phospholipid binding|mitochondrial matrix|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|regulation of epidermal growth factor-activated receptor activity|Ras protein signal transduction|axon guidance|heart development|positive regulation of cell population proliferation|insulin receptor signaling pathway|viral process|cytokine-mediated signaling pathway|protein kinase binding|receptor tyrosine kinase binding|actin cytoskeleton reorganization|interleukin-15-mediated signaling pathway|IRE1-mediated unfolded protein response|Fc-epsilon receptor signaling pathway|interleukin-2-mediated signaling pathway|ERBB2 signaling pathway|regulation of growth|defense response to bacterium|negative regulation of apoptotic process|positive regulation of MAPK cascade|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of Ras protein signal transduction|ephrin receptor binding|epidermal growth factor binding|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|Shc-EGFR complex|cellular response to growth factor stimulus|cell-cell adhesion" "hsa01521,hsa01522,hsa04012,hsa04014,hsa04062,hsa04072,hsa04510,hsa04650,hsa04722,hsa04910,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05100,hsa05206,hsa05214,hsa05220,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|Neurotrophin signaling pathway|Insulin signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Bacterial invasion of epithelial cells|MicroRNAs in cancer|Glioma|Chronic myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer" SHC3 285.9909371 422.2216828 149.7601913 0.354695643 -1.495346486 0.002204379 0.151665743 1.015965352 0.375881266 53358 SHC adaptor protein 3 "GO:0000165,GO:0001784,GO:0005515,GO:0005575,GO:0005829,GO:0005886,GO:0007169,GO:0007173,GO:0007265,GO:0007411,GO:0007417,GO:0019901,GO:0030971" MAPK cascade|phosphotyrosine residue binding|protein binding|cellular_component|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|Ras protein signal transduction|axon guidance|central nervous system development|protein kinase binding|receptor tyrosine kinase binding "hsa01521,hsa01522,hsa04012,hsa04014,hsa04062,hsa04072,hsa04510,hsa04650,hsa04722,hsa04910,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05100,hsa05214,hsa05220,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|Neurotrophin signaling pathway|Insulin signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Bacterial invasion of epithelial cells|Glioma|Chronic myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer" SHC4 24.92852593 20.29911937 29.5579325 1.456118956 0.542128219 0.621829077 1 0.197783529 0.300402061 399694 SHC adaptor protein 4 "GO:0005515,GO:0005886,GO:0006915,GO:0007169,GO:0008284,GO:0010468,GO:0019901,GO:0019904,GO:0030971,GO:0035556,GO:0045211,GO:0048863" protein binding|plasma membrane|apoptotic process|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of cell population proliferation|regulation of gene expression|protein kinase binding|protein domain specific binding|receptor tyrosine kinase binding|intracellular signal transduction|postsynaptic membrane|stem cell differentiation "hsa01521,hsa01522,hsa04012,hsa04014,hsa04062,hsa04072,hsa04510,hsa04650,hsa04722,hsa04910,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05100,hsa05206,hsa05214,hsa05220,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|Neurotrophin signaling pathway|Insulin signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Bacterial invasion of epithelial cells|MicroRNAs in cancer|Glioma|Chronic myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer" SHCBP1 822.3483996 784.5609636 860.1358356 1.096327597 0.132678958 0.718573491 1 6.451574126 7.37771658 79801 SHC binding and spindle associated 1 "GO:0005515,GO:0005737,GO:0005819,GO:0008543,GO:0030496,GO:2000177" protein binding|cytoplasm|spindle|fibroblast growth factor receptor signaling pathway|midbody|regulation of neural precursor cell proliferation SHE 26.42126833 21.31407534 31.52846133 1.479231955 0.564848296 0.598127945 1 0.102088398 0.157517424 126669 Src homology 2 domain containing E "GO:0001784,GO:0005515" phosphotyrosine residue binding|protein binding SHF 65.27710808 50.74779842 79.80641774 1.572608472 0.653159532 0.405767023 1 0.674061621 1.105697026 90525 Src homology 2 domain containing F "GO:0001784,GO:0006915" phosphotyrosine residue binding|apoptotic process SHFL 431.3795432 392.7879598 469.9711267 1.196500847 0.258821419 0.544090858 1 7.752659583 9.675638967 55337 shiftless antiviral inhibitor of ribosomal frameshifting "GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006449,GO:0034340,GO:0034341,GO:0034342,GO:0035456,GO:0043022,GO:0045071,GO:0051607,GO:0075523,GO:1990825,GO:2001125" P-body|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of translational termination|response to type I interferon|response to interferon-gamma|response to type III interferon|response to interferon-beta|ribosome binding|negative regulation of viral genome replication|defense response to virus|viral translational frameshifting|sequence-specific mRNA binding|negative regulation of translational frameshifting SHH 392.5249412 531.8369274 253.2129551 0.476110142 -1.070632734 0.014742288 0.53522651 5.11016205 2.537803751 6469 sonic hedgehog signaling molecule "GO:0000122,GO:0001569,GO:0001570,GO:0001656,GO:0001658,GO:0001708,GO:0001755,GO:0001947,GO:0002052,GO:0002076,GO:0002320,GO:0003140,GO:0005113,GO:0005509,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0005788,GO:0005829,GO:0005886,GO:0006897,GO:0007224,GO:0007228,GO:0007267,GO:0007389,GO:0007398,GO:0007405,GO:0007411,GO:0007417,GO:0007418,GO:0007442,GO:0007507,GO:0007596,GO:0008209,GO:0008233,GO:0008270,GO:0008284,GO:0009880,GO:0009949,GO:0009953,GO:0009986,GO:0010468,GO:0014003,GO:0014706,GO:0014858,GO:0014902,GO:0016015,GO:0016539,GO:0016540,GO:0021513,GO:0021522,GO:0021794,GO:0021904,GO:0021930,GO:0021938,GO:0021978,GO:0030010,GO:0030162,GO:0030177,GO:0030324,GO:0030326,GO:0030336,GO:0030539,GO:0030850,GO:0030878,GO:0030900,GO:0030901,GO:0030902,GO:0031016,GO:0031069,GO:0032435,GO:0033077,GO:0033089,GO:0033092,GO:0034244,GO:0034504,GO:0035115,GO:0035116,GO:0042127,GO:0042130,GO:0042307,GO:0042475,GO:0042481,GO:0042733,GO:0043010,GO:0043066,GO:0043237,GO:0043369,GO:0045059,GO:0045060,GO:0045109,GO:0045121,GO:0045445,GO:0045596,GO:0045880,GO:0045893,GO:0045944,GO:0046638,GO:0046639,GO:0048468,GO:0048538,GO:0048557,GO:0048617,GO:0048643,GO:0048645,GO:0048663,GO:0048706,GO:0048709,GO:0048714,GO:0048745,GO:0048754,GO:0048839,GO:0048859,GO:0048864,GO:0051155,GO:0051781,GO:0060020,GO:0060021,GO:0060070,GO:0060174,GO:0060428,GO:0060439,GO:0060445,GO:0060447,GO:0060458,GO:0060459,GO:0060463,GO:0060484,GO:0060516,GO:0060523,GO:0060662,GO:0060664,GO:0060685,GO:0060738,GO:0060769,GO:0060782,GO:0060783,GO:0060840,GO:0060916,GO:0061053,GO:0061189,GO:0062023,GO:0071285,GO:0071542,GO:0072136,GO:0072205,GO:0090090,GO:0090370,GO:0097190,GO:1900175,GO:1900180,GO:1904339,GO:1905327,GO:2000062,GO:2000063,GO:2000357,GO:2000358,GO:2000729,GO:2001054" "negative regulation of transcription by RNA polymerase II|branching involved in blood vessel morphogenesis|vasculogenesis|metanephros development|branching involved in ureteric bud morphogenesis|cell fate specification|neural crest cell migration|heart looping|positive regulation of neuroblast proliferation|osteoblast development|lymphoid progenitor cell differentiation|determination of left/right asymmetry in lateral mesoderm|patched binding|calcium ion binding|protein binding|glycosaminoglycan binding|extracellular region|extracellular space|endoplasmic reticulum lumen|cytosol|plasma membrane|endocytosis|smoothened signaling pathway|positive regulation of hh target transcription factor activity|cell-cell signaling|pattern specification process|ectoderm development|neuroblast proliferation|axon guidance|central nervous system development|ventral midline development|hindgut morphogenesis|heart development|blood coagulation|androgen metabolic process|peptidase activity|zinc ion binding|positive regulation of cell population proliferation|embryonic pattern specification|polarity specification of anterior/posterior axis|dorsal/ventral pattern formation|cell surface|regulation of gene expression|oligodendrocyte development|striated muscle tissue development|positive regulation of skeletal muscle cell proliferation|myotube differentiation|morphogen activity|intein-mediated protein splicing|protein autoprocessing|spinal cord dorsal/ventral patterning|spinal cord motor neuron differentiation|thalamus development|dorsal/ventral neural tube patterning|cerebellar granule cell precursor proliferation|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|telencephalon regionalization|establishment of cell polarity|regulation of proteolysis|positive regulation of Wnt signaling pathway|lung development|embryonic limb morphogenesis|negative regulation of cell migration|male genitalia development|prostate gland development|thyroid gland development|forebrain development|midbrain development|hindbrain development|pancreas development|hair follicle morphogenesis|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|T cell differentiation in thymus|positive regulation of T cell differentiation in thymus|positive regulation of immature T cell proliferation in thymus|negative regulation of transcription elongation from RNA polymerase II promoter|protein localization to nucleus|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|regulation of cell population proliferation|negative regulation of T cell proliferation|positive regulation of protein import into nucleus|odontogenesis of dentin-containing tooth|regulation of odontogenesis|embryonic digit morphogenesis|camera-type eye development|negative regulation of apoptotic process|laminin-1 binding|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|positive thymic T cell selection|negative thymic T cell selection|intermediate filament organization|membrane raft|myoblast differentiation|negative regulation of cell differentiation|positive regulation of smoothened signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of alpha-beta T cell differentiation|negative regulation of alpha-beta T cell differentiation|cell development|thymus development|embryonic digestive tract morphogenesis|embryonic foregut morphogenesis|positive regulation of skeletal muscle tissue development|animal organ formation|neuron fate commitment|embryonic skeletal system development|oligodendrocyte differentiation|positive regulation of oligodendrocyte differentiation|smooth muscle tissue development|branching morphogenesis of an epithelial tube|inner ear development|formation of anatomical boundary|stem cell development|positive regulation of striated muscle cell differentiation|positive regulation of cell division|Bergmann glial cell differentiation|roof of mouth development|canonical Wnt signaling pathway|limb bud formation|lung epithelium development|trachea morphogenesis|branching involved in salivary gland morphogenesis|bud outgrowth involved in lung branching|right lung development|left lung development|lung lobe morphogenesis|lung-associated mesenchyme development|primary prostatic bud elongation|prostate epithelial cord elongation|salivary gland cavitation|epithelial cell proliferation involved in salivary gland morphogenesis|regulation of prostatic bud formation|epithelial-mesenchymal signaling involved in prostate gland development|positive regulation of epithelial cell proliferation involved in prostate gland development|regulation of mesenchymal cell proliferation involved in prostate gland development|mesenchymal smoothened signaling pathway involved in prostate gland development|artery development|mesenchymal cell proliferation involved in lung development|somite development|positive regulation of sclerotome development|collagen-containing extracellular matrix|cellular response to lithium ion|dopaminergic neuron differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|metanephric collecting duct development|negative regulation of canonical Wnt signaling pathway|negative regulation of cholesterol efflux|apoptotic signaling pathway|regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|regulation of protein localization to nucleus|negative regulation of dopaminergic neuron differentiation|tracheoesophageal septum formation|negative regulation of ureter smooth muscle cell differentiation|positive regulation of ureter smooth muscle cell differentiation|negative regulation of kidney smooth muscle cell differentiation|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|negative regulation of mesenchymal cell apoptotic process" "hsa04340,hsa04360,hsa05200,hsa05205,hsa05217,hsa05226" Hedgehog signaling pathway|Axon guidance|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Gastric cancer SHISA2 381.7464158 535.8967513 227.5960802 0.424701362 -1.235479359 0.005416632 0.28256493 7.058850435 3.127040915 387914 shisa family member 2 "GO:0005515,GO:0005783,GO:0005789,GO:0007275,GO:0016021,GO:0030178,GO:0040037" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|multicellular organism development|integral component of membrane|negative regulation of Wnt signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway SHISA3 108.6826823 121.7947162 95.57064841 0.784686326 -0.349812035 0.601882428 1 2.656534328 2.174339957 152573 shisa family member 3 "GO:0005515,GO:0005789,GO:0007275,GO:0016021,GO:0090090" protein binding|endoplasmic reticulum membrane|multicellular organism development|integral component of membrane|negative regulation of canonical Wnt signaling pathway SHISA4 531.2690747 519.6574558 542.8806935 1.044689511 0.063074227 0.879858864 1 18.37906208 20.02748932 149345 shisa family member 4 "GO:0005515,GO:0016021" protein binding|integral component of membrane SHISA5 4774.166047 4315.592778 5232.739316 1.21251925 0.278007651 0.385774742 1 66.86128776 84.56279105 51246 shisa family member 5 "GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0016021,GO:0031965,GO:0042771,GO:0043123,GO:0043687,GO:0044267" protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral component of membrane|nuclear membrane|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of I-kappaB kinase/NF-kappaB signaling|post-translational protein modification|cellular protein metabolic process hsa04115 p53 signaling pathway SHISA8 52.79799934 39.58328277 66.01271591 1.667691795 0.73785269 0.379995915 1 0.357863911 0.622514721 440829 shisa family member 8 "GO:0014069,GO:0032281,GO:0032591,GO:0045211,GO:0048172,GO:2000311" postsynaptic density|AMPA glutamate receptor complex|dendritic spine membrane|postsynaptic membrane|regulation of short-term neuronal synaptic plasticity|regulation of AMPA receptor activity SHISAL1 28.62932958 37.55337083 19.70528833 0.524727552 -0.930359552 0.357711282 1 0.269703028 0.147616743 85352 shisa like 1 "GO:0005515,GO:0016021" protein binding|integral component of membrane SHKBP1 1418.582821 1333.652142 1503.5135 1.127365564 0.172955405 0.605301866 1 27.99203323 32.91661285 92799 SH3KBP1 binding protein 1 "GO:0005515,GO:0005764,GO:0042802,GO:0045742,GO:0051260" protein binding|lysosome|identical protein binding|positive regulation of epidermal growth factor receptor signaling pathway|protein homooligomerization SHLD1 77.18663413 90.33108119 64.04218708 0.708971776 -0.496199899 0.506675075 1 1.052196549 0.778111348 149840 shieldin complex subunit 1 "GO:0005515,GO:0005694,GO:0006281,GO:0035861,GO:0045830,GO:2000042,GO:2001034" protein binding|chromosome|DNA repair|site of double-strand break|positive regulation of isotype switching|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining SHLD2 1197.886313 1300.158595 1095.614031 0.84267722 -0.246947969 0.470896994 1 10.80900298 9.500857853 54537 shieldin complex subunit 2 "GO:0005515,GO:0005634,GO:0005694,GO:0006281,GO:0010569,GO:0035861,GO:0045830,GO:2000042,GO:2001034" protein binding|nucleus|chromosome|DNA repair|regulation of double-strand break repair via homologous recombination|site of double-strand break|positive regulation of isotype switching|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining SHLD3 46.60162149 53.79266632 39.41057666 0.732638468 -0.448826641 0.616008704 1 1.767948592 1.351062004 112441434 shieldin complex subunit 3 "GO:0005515,GO:0005694,GO:0006281,GO:0035861,GO:0045830,GO:2000042,GO:2001034" protein binding|chromosome|DNA repair|site of double-strand break|positive regulation of isotype switching|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining SHMT1 1776.778893 1606.675298 1946.882487 1.211746076 0.27708741 0.394696744 1 30.96363616 39.13627682 6470 serine hydroxymethyltransferase 1 "GO:0000900,GO:0004372,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006544,GO:0006563,GO:0006565,GO:0006730,GO:0008270,GO:0008732,GO:0009113,GO:0017148,GO:0019264,GO:0030170,GO:0035999,GO:0036094,GO:0042802,GO:0042803,GO:0045329,GO:0046653,GO:0046655,GO:0048027,GO:0050897,GO:0051289,GO:0070062,GO:0070905,GO:1904482,GO:1990830" "translation repressor activity, mRNA regulatory element binding|glycine hydroxymethyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|glycine metabolic process|L-serine metabolic process|L-serine catabolic process|one-carbon metabolic process|zinc ion binding|L-allo-threonine aldolase activity|purine nucleobase biosynthetic process|negative regulation of translation|glycine biosynthetic process from serine|pyridoxal phosphate binding|tetrahydrofolate interconversion|small molecule binding|identical protein binding|protein homodimerization activity|carnitine biosynthetic process|tetrahydrofolate metabolic process|folic acid metabolic process|mRNA 5'-UTR binding|cobalt ion binding|protein homotetramerization|extracellular exosome|serine binding|cellular response to tetrahydrofolate|cellular response to leukemia inhibitory factor" "hsa00260,hsa00630,hsa00670,hsa01523" "Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism|One carbon pool by folate|Antifolate resistance" SHMT2 4991.528936 4222.216828 5760.841044 1.364411464 0.448278782 0.16313937 1 79.94033169 113.7698631 6472 serine hydroxymethyltransferase 2 "GO:0000900,GO:0002082,GO:0003682,GO:0004372,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0005829,GO:0006544,GO:0006563,GO:0006564,GO:0006565,GO:0006730,GO:0008270,GO:0008284,GO:0008732,GO:0009113,GO:0015630,GO:0017148,GO:0019264,GO:0030170,GO:0034340,GO:0035999,GO:0042645,GO:0042803,GO:0046653,GO:0046655,GO:0048027,GO:0050897,GO:0051262,GO:0051289,GO:0070062,GO:0070129,GO:0070536,GO:0070552,GO:0070905,GO:1903715" "translation repressor activity, mRNA regulatory element binding|regulation of oxidative phosphorylation|chromatin binding|glycine hydroxymethyltransferase activity|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|cytosol|glycine metabolic process|L-serine metabolic process|L-serine biosynthetic process|L-serine catabolic process|one-carbon metabolic process|zinc ion binding|positive regulation of cell population proliferation|L-allo-threonine aldolase activity|purine nucleobase biosynthetic process|microtubule cytoskeleton|negative regulation of translation|glycine biosynthetic process from serine|pyridoxal phosphate binding|response to type I interferon|tetrahydrofolate interconversion|mitochondrial nucleoid|protein homodimerization activity|tetrahydrofolate metabolic process|folic acid metabolic process|mRNA 5'-UTR binding|cobalt ion binding|protein tetramerization|protein homotetramerization|extracellular exosome|regulation of mitochondrial translation|protein K63-linked deubiquitination|BRISC complex|serine binding|regulation of aerobic respiration" "hsa00260,hsa00630,hsa00670,hsa01523" "Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism|One carbon pool by folate|Antifolate resistance" SHOC2 619.7092991 638.4073041 601.0112941 0.94142296 -0.087085056 0.825894831 1 7.808036172 7.667301343 8036 SHOC2 leucine rich repeat scaffold protein "GO:0000164,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0007265,GO:0008157,GO:0008543,GO:0019888,GO:0019903,GO:0043666,GO:0046579" protein phosphatase type 1 complex|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|Ras protein signal transduction|protein phosphatase 1 binding|fibroblast growth factor receptor signaling pathway|protein phosphatase regulator activity|protein phosphatase binding|regulation of phosphoprotein phosphatase activity|positive regulation of Ras protein signal transduction hsa04014 Ras signaling pathway SHOX2 13.01627828 14.20938356 11.823173 0.832067975 -0.265226703 0.893085452 1 0.184290691 0.15994775 6474 short stature homeobox 2 "GO:0000122,GO:0000785,GO:0000981,GO:0001501,GO:0001649,GO:0002053,GO:0002063,GO:0003170,GO:0003209,GO:0005634,GO:0006357,GO:0007399,GO:0007507,GO:0032330,GO:0035115,GO:0045880,GO:0048557,GO:0048743,GO:0050772,GO:0060272,GO:0060351,GO:0060415,GO:0060931,GO:1990837,GO:2000172" "negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|skeletal system development|osteoblast differentiation|positive regulation of mesenchymal cell proliferation|chondrocyte development|heart valve development|cardiac atrium morphogenesis|nucleus|regulation of transcription by RNA polymerase II|nervous system development|heart development|regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|positive regulation of smoothened signaling pathway|embryonic digestive tract morphogenesis|positive regulation of skeletal muscle fiber development|positive regulation of axonogenesis|embryonic skeletal joint morphogenesis|cartilage development involved in endochondral bone morphogenesis|muscle tissue morphogenesis|sinoatrial node cell development|sequence-specific double-stranded DNA binding|regulation of branching morphogenesis of a nerve" SHPK 1657.163784 1545.77794 1768.549628 1.144116229 0.194233621 0.553935721 1 20.6674233 24.66450537 23729 sedoheptulokinase "GO:0005524,GO:0005737,GO:0005829,GO:0005975,GO:0006098,GO:0009052,GO:0016310,GO:0016773,GO:0035963,GO:0043030,GO:0050277,GO:0050727,GO:0071222,GO:0071353" "ATP binding|cytoplasm|cytosol|carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|phosphorylation|phosphotransferase activity, alcohol group as acceptor|cellular response to interleukin-13|regulation of macrophage activation|sedoheptulokinase activity|regulation of inflammatory response|cellular response to lipopolysaccharide|cellular response to interleukin-4" SHPRH 505.664324 554.1659587 457.1626893 0.824956283 -0.277610427 0.49694421 1 1.735824778 1.493663428 257218 SNF2 histone linker PHD RING helicase "GO:0000209,GO:0000786,GO:0003677,GO:0004386,GO:0004842,GO:0005515,GO:0005524,GO:0005654,GO:0006281,GO:0006334,GO:0006974,GO:0016567,GO:0031625,GO:0046872,GO:0061630" protein polyubiquitination|nucleosome|DNA binding|helicase activity|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleoplasm|DNA repair|nucleosome assembly|cellular response to DNA damage stimulus|protein ubiquitination|ubiquitin protein ligase binding|metal ion binding|ubiquitin protein ligase activity SHQ1 336.1976066 385.683268 286.7119452 0.743387046 -0.427814547 0.349300001 1 2.979029574 2.309966774 55164 "SHQ1, H/ACA ribonucleoprotein assembly factor" "GO:0000493,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0015030,GO:0022618,GO:0043065,GO:0051082,GO:1904874,GO:2000233" box H/ACA snoRNP assembly|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|Cajal body|ribonucleoprotein complex assembly|positive regulation of apoptotic process|unfolded protein binding|positive regulation of telomerase RNA localization to Cajal body|negative regulation of rRNA processing SHROOM1 431.154135 411.0571672 451.2511028 1.097781863 0.134591409 0.755196843 1 4.287190156 4.909132203 134549 shroom family member 1 "GO:0000902,GO:0005874,GO:0005912,GO:0007015,GO:0016324,GO:0030864,GO:0043296,GO:0045159,GO:0051015,GO:0051017" cell morphogenesis|microtubule|adherens junction|actin filament organization|apical plasma membrane|cortical actin cytoskeleton|apical junction complex|myosin II binding|actin filament binding|actin filament bundle assembly SHROOM2 178.06143 217.2005772 138.9222827 0.639603653 -0.644749915 0.250016846 1 1.336464949 0.89162952 357 shroom family member 2 "GO:0000902,GO:0002089,GO:0003779,GO:0005515,GO:0005856,GO:0005874,GO:0005886,GO:0005912,GO:0005923,GO:0007015,GO:0007420,GO:0008013,GO:0008057,GO:0015280,GO:0016324,GO:0016477,GO:0030864,GO:0032401,GO:0032438,GO:0035725,GO:0043010,GO:0043296,GO:0043482,GO:0043583,GO:0045176,GO:0048593,GO:0051015,GO:0051017,GO:0070062" cell morphogenesis|lens morphogenesis in camera-type eye|actin binding|protein binding|cytoskeleton|microtubule|plasma membrane|adherens junction|bicellular tight junction|actin filament organization|brain development|beta-catenin binding|eye pigment granule organization|ligand-gated sodium channel activity|apical plasma membrane|cell migration|cortical actin cytoskeleton|establishment of melanosome localization|melanosome organization|sodium ion transmembrane transport|camera-type eye development|apical junction complex|cellular pigment accumulation|ear development|apical protein localization|camera-type eye morphogenesis|actin filament binding|actin filament bundle assembly|extracellular exosome SHROOM3 328.1751983 275.0530674 381.2973292 1.386268231 0.471206434 0.306066768 1 1.279080666 1.849528956 57619 shroom family member 3 "GO:0000902,GO:0001843,GO:0002064,GO:0005856,GO:0005874,GO:0005912,GO:0007015,GO:0007389,GO:0008360,GO:0016324,GO:0030864,GO:0043296,GO:0043482,GO:0045176,GO:0051015" cell morphogenesis|neural tube closure|epithelial cell development|cytoskeleton|microtubule|adherens junction|actin filament organization|pattern specification process|regulation of cell shape|apical plasma membrane|cortical actin cytoskeleton|apical junction complex|cellular pigment accumulation|apical protein localization|actin filament binding SHROOM4 19.55410897 23.34398727 15.76423066 0.675301545 -0.566396237 0.63648619 1 0.112986487 0.079586642 57477 shroom family member 4 "GO:0000902,GO:0001725,GO:0005654,GO:0005737,GO:0005884,GO:0005912,GO:0005925,GO:0007015,GO:0007420,GO:0009898,GO:0009925,GO:0015629,GO:0016324,GO:0030036,GO:0030864,GO:0043231,GO:0043296,GO:0045159,GO:0050890,GO:0051015" cell morphogenesis|stress fiber|nucleoplasm|cytoplasm|actin filament|adherens junction|focal adhesion|actin filament organization|brain development|cytoplasmic side of plasma membrane|basal plasma membrane|actin cytoskeleton|apical plasma membrane|actin cytoskeleton organization|cortical actin cytoskeleton|intracellular membrane-bounded organelle|apical junction complex|myosin II binding|cognition|actin filament binding SHTN1 1102.963682 1041.344824 1164.58254 1.118344773 0.161365023 0.642796472 1 3.520018799 4.106167156 57698 shootin 1 "GO:0005515,GO:0005737,GO:0005874,GO:0005875,GO:0006930,GO:0007265,GO:0007409,GO:0015630,GO:0019894,GO:0030027,GO:0030175,GO:0030424,GO:0030426,GO:0031252,GO:0032488,GO:0038007,GO:0043204,GO:0044295,GO:0045296,GO:0045773,GO:0048471,GO:0048812,GO:0051015,GO:0060327,GO:0061163,GO:0061573,GO:2000114,GO:2001224" "protein binding|cytoplasm|microtubule|microtubule associated complex|substrate-dependent cell migration, cell extension|Ras protein signal transduction|axonogenesis|microtubule cytoskeleton|kinesin binding|lamellipodium|filopodium|axon|growth cone|cell leading edge|Cdc42 protein signal transduction|netrin-activated signaling pathway|perikaryon|axonal growth cone|cadherin binding|positive regulation of axon extension|perinuclear region of cytoplasm|neuron projection morphogenesis|actin filament binding|cytoplasmic actin-based contraction involved in cell motility|endoplasmic reticulum polarization|actin filament bundle retrograde transport|regulation of establishment of cell polarity|positive regulation of neuron migration" SIAE 587.1010555 699.3046622 474.8974488 0.679099503 -0.558305118 0.15559321 1 4.179527277 2.960577992 54414 sialic acid acetylesterase "GO:0001681,GO:0002682,GO:0005615,GO:0005764,GO:0005975,GO:0070062,GO:0106330,GO:0106331" sialate O-acetylesterase activity|regulation of immune system process|extracellular space|lysosome|carbohydrate metabolic process|extracellular exosome|sialate 9-O-acetylesterase activity|sialate 4-O-acetylesterase activity SIAH1 303.1251846 280.1278473 326.1225219 1.164191726 0.219328669 0.645325209 1 1.503389555 1.825626649 6477 siah E3 ubiquitin protein ligase 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0006511,GO:0006915,GO:0007049,GO:0007283,GO:0007399,GO:0007411,GO:0008022,GO:0008270,GO:0009653,GO:0030163,GO:0030877,GO:0031624,GO:0031648,GO:0042802,GO:0043065,GO:0043161,GO:0044267,GO:0051402,GO:0061630,GO:1902842,GO:2001244" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|early endosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|cell cycle|spermatogenesis|nervous system development|axon guidance|protein C-terminus binding|zinc ion binding|anatomical structure morphogenesis|protein catabolic process|beta-catenin destruction complex|ubiquitin conjugating enzyme binding|protein destabilization|identical protein binding|positive regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cellular protein metabolic process|neuron apoptotic process|ubiquitin protein ligase activity|negative regulation of netrin-activated signaling pathway|positive regulation of intrinsic apoptotic signaling pathway "hsa04115,hsa04120,hsa04310" p53 signaling pathway|Ubiquitin mediated proteolysis|Wnt signaling pathway SIAH2 470.5713926 512.552764 428.5900212 0.836187123 -0.258102268 0.535620807 1 11.23279503 9.797318785 6478 siah E3 ubiquitin protein ligase 2 "GO:0000209,GO:0003714,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0006511,GO:0006915,GO:0007049,GO:0007264,GO:0007275,GO:0008270,GO:0016579,GO:0031396,GO:0031624,GO:0042752,GO:0043005,GO:0043025,GO:0043066,GO:0043154,GO:0043161,GO:0043231,GO:0044257,GO:0044267,GO:0045892,GO:0048511,GO:0061630,GO:0090090,GO:1902842,GO:2001237" "protein polyubiquitination|transcription corepressor activity|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|early endosome|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|cell cycle|small GTPase mediated signal transduction|multicellular organism development|zinc ion binding|protein deubiquitination|regulation of protein ubiquitination|ubiquitin conjugating enzyme binding|regulation of circadian rhythm|neuron projection|neuronal cell body|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|cellular protein catabolic process|cellular protein metabolic process|negative regulation of transcription, DNA-templated|rhythmic process|ubiquitin protein ligase activity|negative regulation of canonical Wnt signaling pathway|negative regulation of netrin-activated signaling pathway|negative regulation of extrinsic apoptotic signaling pathway" SIDT1 17.55388858 21.31407534 13.79370183 0.64716398 -0.627796782 0.611011459 1 0.20207464 0.136408703 54847 SID1 transmembrane family member 1 "GO:0003725,GO:0005764,GO:0005886,GO:0015485,GO:0016021,GO:0050658,GO:0051033" double-stranded RNA binding|lysosome|plasma membrane|cholesterol binding|integral component of membrane|RNA transport|RNA transmembrane transporter activity SIDT2 690.221769 743.9627248 636.4808131 0.855527827 -0.225113315 0.553662951 1 8.571220989 7.648790436 51092 SID1 transmembrane family member 2 "GO:0003677,GO:0003725,GO:0005764,GO:0005765,GO:0005886,GO:0006401,GO:0016021,GO:0035612,GO:0035650,GO:0050658,GO:0051032,GO:0051033" DNA binding|double-stranded RNA binding|lysosome|lysosomal membrane|plasma membrane|RNA catabolic process|integral component of membrane|AP-2 adaptor complex binding|AP-1 adaptor complex binding|RNA transport|nucleic acid transmembrane transporter activity|RNA transmembrane transporter activity SIGIRR 438.3330556 430.3413306 446.3247807 1.037141332 0.052612504 0.906300846 1 10.20855749 11.04379281 59307 single Ig and TIR domain containing "GO:0001960,GO:0005515,GO:0005886,GO:0006953,GO:0007165,GO:0016020,GO:0016021,GO:0031665,GO:0032682,GO:0043433,GO:0071345" negative regulation of cytokine-mediated signaling pathway|protein binding|plasma membrane|acute-phase response|signal transduction|membrane|integral component of membrane|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of chemokine production|negative regulation of DNA-binding transcription factor activity|cellular response to cytokine stimulus SIGLEC1 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.014777617 0.029926499 6614 sialic acid binding Ig like lectin 1 "GO:0005576,GO:0005769,GO:0005770,GO:0005886,GO:0006954,GO:0007160,GO:0016021,GO:0030246,GO:0046790,GO:0075512,GO:0098609" extracellular region|early endosome|late endosome|plasma membrane|inflammatory response|cell-matrix adhesion|integral component of membrane|carbohydrate binding|virion binding|clathrin-dependent endocytosis of virus by host cell|cell-cell adhesion hsa04514 Cell adhesion molecules SIGLEC15 2440.45197 3162.602797 1718.301142 0.543318669 -0.880129475 0.006135477 0.310299445 54.33333606 30.79193131 284266 sialic acid binding Ig like lectin 15 "GO:0005886,GO:0016021,GO:0032956,GO:0032991,GO:0045087,GO:0045124,GO:2001204" plasma membrane|integral component of membrane|regulation of actin cytoskeleton organization|protein-containing complex|innate immune response|regulation of bone resorption|regulation of osteoclast development SIGMAR1 2828.408864 2775.904574 2880.913154 1.037828599 0.053568197 0.867320865 1 82.94381938 89.78950837 10280 sigma non-opioid intracellular receptor 1 "GO:0004985,GO:0005515,GO:0005635,GO:0005637,GO:0005640,GO:0005783,GO:0005789,GO:0005811,GO:0006869,GO:0007399,GO:0014069,GO:0016020,GO:0016021,GO:0030426,GO:0031410,GO:0036474,GO:0038003,GO:0043523,GO:0070207,GO:0098839" opioid receptor activity|protein binding|nuclear envelope|nuclear inner membrane|nuclear outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|lipid transport|nervous system development|postsynaptic density|membrane|integral component of membrane|growth cone|cytoplasmic vesicle|cell death in response to hydrogen peroxide|opioid receptor signaling pathway|regulation of neuron apoptotic process|protein homotrimerization|postsynaptic density membrane "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases SIK1 90.78461927 110.6302006 70.93903799 0.641226696 -0.641093605 0.361688188 1 1.181575154 0.790294346 150094 salt inducible kinase 1 "GO:0000287,GO:0002028,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007049,GO:0007346,GO:0008140,GO:0010830,GO:0010868,GO:0019901,GO:0032792,GO:0035556,GO:0042149,GO:0043153,GO:0045595,GO:0045721,GO:0046777,GO:0048511,GO:0055007,GO:0071889,GO:0106310,GO:0106311,GO:2000210" magnesium ion binding|regulation of sodium ion transport|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|cell cycle|regulation of mitotic cell cycle|cAMP response element binding protein binding|regulation of myotube differentiation|negative regulation of triglyceride biosynthetic process|protein kinase binding|negative regulation of CREB transcription factor activity|intracellular signal transduction|cellular response to glucose starvation|entrainment of circadian clock by photoperiod|regulation of cell differentiation|negative regulation of gluconeogenesis|protein autophosphorylation|rhythmic process|cardiac muscle cell differentiation|14-3-3 protein binding|protein serine kinase activity|protein threonine kinase activity|positive regulation of anoikis hsa04922 Glucagon signaling pathway SIK1B 365.5125635 436.4310664 294.5940605 0.675007082 -0.567025457 0.202960043 1 4.681994043 3.296515452 102724428 salt inducible kinase 1B (putative) "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0035556,GO:0042149,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|intracellular signal transduction|cellular response to glucose starvation|protein serine kinase activity|protein threonine kinase activity hsa04922 Glucagon signaling pathway SIK2 691.7766161 715.5439577 668.0092744 0.933568465 -0.099172265 0.796347624 1 7.078081479 6.892514061 23235 salt inducible kinase 2 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0035556,GO:0042149,GO:0046626,GO:0046777,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|intracellular signal transduction|cellular response to glucose starvation|regulation of insulin receptor signaling pathway|protein autophosphorylation|protein serine kinase activity|protein threonine kinase activity hsa04922 Glucagon signaling pathway SIK3 624.6774369 674.945719 574.4091548 0.851044964 -0.232692738 0.549402427 1 4.059812304 3.60391377 23387 SIK family kinase 3 "GO:0000226,GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0035556,GO:0050321,GO:0106310,GO:0106311,GO:1904263,GO:1904515" microtubule cytoskeleton organization|magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|intracellular signal transduction|tau-protein kinase activity|protein serine kinase activity|protein threonine kinase activity|positive regulation of TORC1 signaling|positive regulation of TORC2 signaling SIKE1 1174.350815 1038.299956 1310.401674 1.262064654 0.335785819 0.328060495 1 9.55071374 12.57283922 80143 suppressor of IKBKE 1 "GO:0005515,GO:0005829,GO:0019901,GO:0031267" protein binding|cytosol|protein kinase binding|small GTPase binding hsa04622 RIG-I-like receptor signaling pathway SIL1 716.8333108 811.9647747 621.7018468 0.765675884 -0.385194276 0.305551088 1 19.08266886 15.24052798 64374 SIL1 nucleotide exchange factor "GO:0000774,GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0006457,GO:0006613,GO:0006886,GO:0050790,GO:0051082" adenyl-nucleotide exchange factor activity|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|cotranslational protein targeting to membrane|intracellular protein transport|regulation of catalytic activity|unfolded protein binding hsa04141 Protein processing in endoplasmic reticulum SIM2 693.8349818 553.1510028 834.5189608 1.508663921 0.593271458 0.117302503 1 4.828532728 7.59842557 6493 SIM bHLH transcription factor 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0003677,GO:0003700,GO:0005654,GO:0006357,GO:0007399,GO:0009880,GO:0016604,GO:0030154,GO:0030324,GO:0046982" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleoplasm|regulation of transcription by RNA polymerase II|nervous system development|embryonic pattern specification|nuclear body|cell differentiation|lung development|protein heterodimerization activity" SIMC1 159.3320035 149.1985274 169.4654796 1.135838823 0.183758129 0.759483043 1 0.902254217 1.068960258 375484 SUMO interacting motifs containing 1 "GO:0005515,GO:0005737,GO:0010466,GO:0030017,GO:0030414,GO:0032184" protein binding|cytoplasm|negative regulation of peptidase activity|sarcomere|peptidase inhibitor activity|SUMO polymer binding SIN3A 3639.028608 3499.568179 3778.489037 1.079701507 0.110632522 0.728570062 1 23.82268582 26.82936295 25942 SIN3 transcription regulator family member A "GO:0000118,GO:0000122,GO:0000776,GO:0000785,GO:0001102,GO:0001103,GO:0001701,GO:0002218,GO:0002230,GO:0002244,GO:0003677,GO:0003682,GO:0003713,GO:0003714,GO:0003723,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006260,GO:0006476,GO:0007568,GO:0010817,GO:0010971,GO:0016575,GO:0016580,GO:0017053,GO:0019216,GO:0021895,GO:0030516,GO:0031937,GO:0034613,GO:0042754,GO:0043066,GO:0043619,GO:0044877,GO:0045652,GO:0045666,GO:0045892,GO:0045944,GO:0048511,GO:0051595,GO:0071333,GO:0140416,GO:1900181,GO:1901675,GO:1903351,GO:2000678" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|kinetochore|chromatin|RNA polymerase II activating transcription factor binding|RNA polymerase II repressing transcription factor binding|in utero embryonic development|activation of innate immune response|positive regulation of defense response to virus by host|hematopoietic progenitor cell differentiation|DNA binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|RNA binding|histone deacetylase activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA replication|protein deacetylation|aging|regulation of hormone levels|positive regulation of G2/M transition of mitotic cell cycle|histone deacetylation|Sin3 complex|transcription repressor complex|regulation of lipid metabolic process|cerebral cortex neuron differentiation|regulation of axon extension|positive regulation of chromatin silencing|cellular protein localization|negative regulation of circadian rhythm|negative regulation of apoptotic process|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|protein-containing complex binding|regulation of megakaryocyte differentiation|positive regulation of neuron differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|rhythmic process|response to methylglyoxal|cellular response to glucose stimulus|transcription regulator inhibitor activity|negative regulation of protein localization to nucleus|negative regulation of histone H3-K27 acetylation|cellular response to dopamine|negative regulation of transcription regulatory region DNA binding" "hsa04919,hsa05016,hsa05169,hsa05202" Thyroid hormone signaling pathway|Huntington disease|Epstein-Barr virus infection|Transcriptional misregulation in cancer other SIN3B 1708.07068 1893.907837 1522.233524 0.803752693 -0.315176429 0.33478112 1 17.29530304 14.49995139 23309 SIN3 transcription regulator family member B "GO:0000118,GO:0000122,GO:0000785,GO:0000805,GO:0000806,GO:0001741,GO:0003682,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016575,GO:0016580,GO:0019216,GO:0030849" histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|X chromosome|Y chromosome|XY body|chromatin binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|histone deacetylation|Sin3 complex|regulation of lipid metabolic process|autosome SINHCAF 1494.894792 1532.583512 1457.206072 0.950816749 -0.072760778 0.827983324 1 22.62312686 22.43703078 58516 SIN3-HDAC complex associated factor "GO:0005515,GO:0008284,GO:0016580,GO:0030336,GO:0045596" protein binding|positive regulation of cell population proliferation|Sin3 complex|negative regulation of cell migration|negative regulation of cell differentiation SIPA1 1422.564457 1201.707867 1643.421047 1.367571181 0.451615927 0.176288961 1 15.79197303 22.52694319 6494 signal-induced proliferation-associated 1 "GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007010,GO:0007162,GO:0007165,GO:0008022,GO:0016020,GO:0030133,GO:0030308,GO:0032991,GO:0035556,GO:0042631,GO:0045786,GO:0048471,GO:0051056,GO:0090630" GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton organization|negative regulation of cell adhesion|signal transduction|protein C-terminus binding|membrane|transport vesicle|negative regulation of cell growth|protein-containing complex|intracellular signal transduction|cellular response to water deprivation|negative regulation of cell cycle|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|activation of GTPase activity "hsa04015,hsa04670" Rap1 signaling pathway|Leukocyte transendothelial migration SIPA1L1 1722.466378 1834.025435 1610.907321 0.878345137 -0.187140152 0.566958224 1 8.269110498 7.575999302 26037 signal induced proliferation associated 1 like 1 "GO:0003674,GO:0005096,GO:0005575,GO:0005737,GO:0005886,GO:0008150,GO:0014069,GO:0015629,GO:0031532,GO:0043087,GO:0043197,GO:0046875,GO:0048013,GO:0048167,GO:0048814,GO:0050770,GO:0051056,GO:0061001,GO:0090630" molecular_function|GTPase activator activity|cellular_component|cytoplasm|plasma membrane|biological_process|postsynaptic density|actin cytoskeleton|actin cytoskeleton reorganization|regulation of GTPase activity|dendritic spine|ephrin receptor binding|ephrin receptor signaling pathway|regulation of synaptic plasticity|regulation of dendrite morphogenesis|regulation of axonogenesis|regulation of small GTPase mediated signal transduction|regulation of dendritic spine morphogenesis|activation of GTPase activity hsa04015 Rap1 signaling pathway SIPA1L2 772.6383217 956.0885222 589.1881211 0.616248504 -0.698415857 0.059550009 1 6.863573462 4.41186377 57568 signal induced proliferation associated 1 like 2 "GO:0005096,GO:0005575,GO:0005737,GO:0008150,GO:0051056,GO:0090630" GTPase activator activity|cellular_component|cytoplasm|biological_process|regulation of small GTPase mediated signal transduction|activation of GTPase activity hsa04015 Rap1 signaling pathway SIPA1L3 2458.423516 2269.441545 2647.405487 1.166544912 0.222241852 0.48647976 1 11.60884842 14.12558796 23094 signal induced proliferation associated 1 like 3 "GO:0001654,GO:0001725,GO:0002244,GO:0003382,GO:0005096,GO:0005515,GO:0005615,GO:0005654,GO:0005737,GO:0005794,GO:0005886,GO:0007010,GO:0016324,GO:0045177,GO:0051056,GO:0061689,GO:0090162,GO:0090630" eye development|stress fiber|hematopoietic progenitor cell differentiation|epithelial cell morphogenesis|GTPase activator activity|protein binding|extracellular space|nucleoplasm|cytoplasm|Golgi apparatus|plasma membrane|cytoskeleton organization|apical plasma membrane|apical part of cell|regulation of small GTPase mediated signal transduction|tricellular tight junction|establishment of epithelial cell polarity|activation of GTPase activity hsa04015 Rap1 signaling pathway SIRPA 2600.94392 2448.073796 2753.814044 1.124890128 0.169784095 0.594692844 1 26.72694578 31.35995043 140885 signal regulatory protein alpha "GO:0001933,GO:0005886,GO:0005887,GO:0007155,GO:0009986,GO:0010468,GO:0016020,GO:0016477,GO:0017124,GO:0019903,GO:0030695,GO:0032649,GO:0032651,GO:0032675,GO:0032680,GO:0032688,GO:0032715,GO:0032720,GO:0034113,GO:0035696,GO:0043312,GO:0045019,GO:0045428,GO:0046329,GO:0050728,GO:0050765,GO:0050766,GO:0050790,GO:0050870,GO:0050900,GO:0070062,GO:0070301,GO:0070373,GO:0070821,GO:0071222,GO:0071346,GO:0071347,GO:0071349,GO:0071641,GO:0071650,GO:0086080,GO:0098632,GO:0101003,GO:1900016,GO:1903720,GO:1990405,GO:1990782" negative regulation of protein phosphorylation|plasma membrane|integral component of plasma membrane|cell adhesion|cell surface|regulation of gene expression|membrane|cell migration|SH3 domain binding|protein phosphatase binding|GTPase regulator activity|regulation of interferon-gamma production|regulation of interleukin-1 beta production|regulation of interleukin-6 production|regulation of tumor necrosis factor production|negative regulation of interferon-beta production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|heterotypic cell-cell adhesion|monocyte extravasation|neutrophil degranulation|negative regulation of nitric oxide biosynthetic process|regulation of nitric oxide biosynthetic process|negative regulation of JNK cascade|negative regulation of inflammatory response|negative regulation of phagocytosis|positive regulation of phagocytosis|regulation of catalytic activity|positive regulation of T cell activation|leukocyte migration|extracellular exosome|cellular response to hydrogen peroxide|negative regulation of ERK1 and ERK2 cascade|tertiary granule membrane|cellular response to lipopolysaccharide|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to interleukin-12|negative regulation of macrophage inflammatory protein 1 alpha production|negative regulation of chemokine (C-C motif) ligand 5 production|protein binding involved in heterotypic cell-cell adhesion|cell-cell adhesion mediator activity|ficolin-1-rich granule membrane|negative regulation of cytokine production involved in inflammatory response|negative regulation of I-kappaB phosphorylation|protein antigen binding|protein tyrosine kinase binding hsa04380 Osteoclast differentiation SIRPB1 6941.532026 10093.73711 3789.326946 0.375413675 -1.41344689 2.24E-05 0.005063695 52.62091362 20.6055591 10326 signal regulatory protein beta 1 "GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0007166,GO:0009986,GO:0030667,GO:0043312,GO:0045087,GO:0050766,GO:0050870" protein binding|plasma membrane|integral component of plasma membrane|signal transduction|cell surface receptor signaling pathway|cell surface|secretory granule membrane|neutrophil degranulation|innate immune response|positive regulation of phagocytosis|positive regulation of T cell activation hsa04380 Osteoclast differentiation SIRPB2 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.01159313 0.046955042 284759 signal regulatory protein beta 2 "GO:0005886,GO:0016021" plasma membrane|integral component of membrane SIRPD 147.7436413 198.9313698 96.55591282 0.485372985 -1.042834281 0.081136155 1 12.28679523 6.220569565 128646 signal regulatory protein delta "GO:0005576,GO:0005886" extracellular region|plasma membrane SIRPG 9.553007044 13.19442759 5.911586499 0.448036602 -1.158311499 0.436032871 1 0.337160046 0.157567095 55423 signal regulatory protein gamma "GO:0005515,GO:0005886,GO:0007155,GO:0007267,GO:0008284,GO:0008285,GO:0016020,GO:0016021,GO:0022409,GO:0035556,GO:0050766,GO:0050870,GO:0050900" protein binding|plasma membrane|cell adhesion|cell-cell signaling|positive regulation of cell population proliferation|negative regulation of cell population proliferation|membrane|integral component of membrane|positive regulation of cell-cell adhesion|intracellular signal transduction|positive regulation of phagocytosis|positive regulation of T cell activation|leukocyte migration hsa04380 Osteoclast differentiation SIRT1 725.3362271 888.0864723 562.5859818 0.633481085 -0.658626553 0.079344638 1 10.1052453 6.677231628 23411 sirtuin 1 "GO:0000012,GO:0000122,GO:0000183,GO:0000720,GO:0000731,GO:0000785,GO:0000791,GO:0000792,GO:0000978,GO:0001525,GO:0001542,GO:0001650,GO:0001678,GO:0001934,GO:0001938,GO:0002039,GO:0002821,GO:0003713,GO:0003714,GO:0003950,GO:0004407,GO:0005515,GO:0005634,GO:0005635,GO:0005637,GO:0005654,GO:0005677,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006325,GO:0006346,GO:0006471,GO:0006476,GO:0006642,GO:0006974,GO:0006979,GO:0007179,GO:0007283,GO:0007346,GO:0007517,GO:0007569,GO:0008022,GO:0008134,GO:0008284,GO:0009267,GO:0010629,GO:0010824,GO:0010875,GO:0010883,GO:0010906,GO:0010934,GO:0014068,GO:0016032,GO:0016239,GO:0016567,GO:0016575,GO:0016605,GO:0017136,GO:0018394,GO:0019213,GO:0019899,GO:0030225,GO:0030308,GO:0030512,GO:0031393,GO:0031507,GO:0031648,GO:0032007,GO:0032071,GO:0032088,GO:0032868,GO:0032922,GO:0033210,GO:0033553,GO:0033558,GO:0034391,GO:0034979,GO:0034983,GO:0035098,GO:0035257,GO:0035356,GO:0035358,GO:0042127,GO:0042326,GO:0042393,GO:0042542,GO:0042595,GO:0042632,GO:0042771,GO:0042802,GO:0042981,GO:0043065,GO:0043066,GO:0043124,GO:0043161,GO:0043280,GO:0043398,GO:0043425,GO:0043433,GO:0043518,GO:0043536,GO:0044321,GO:0045348,GO:0045599,GO:0045722,GO:0045739,GO:0045766,GO:0045892,GO:0045944,GO:0046628,GO:0046872,GO:0046969,GO:0050872,GO:0051019,GO:0051097,GO:0051152,GO:0051574,GO:0051898,GO:0055089,GO:0060766,GO:0061647,GO:0070301,GO:0070403,GO:0070829,GO:0070857,GO:0070914,GO:0070932,GO:0071356,GO:0071441,GO:0071456,GO:0071479,GO:0071900,GO:0090335,GO:0090400,GO:0106230,GO:0106231,GO:1900034,GO:1900113,GO:1901215,GO:1901984,GO:1902166,GO:1902176,GO:1902237,GO:1904179,GO:1990254,GO:1990619,GO:1990830,GO:1990841,GO:2000111,GO:2000480,GO:2000481,GO:2000619,GO:2000655,GO:2000757,GO:2000773,GO:2000774" "single strand break repair|negative regulation of transcription by RNA polymerase II|rDNA heterochromatin assembly|pyrimidine dimer repair by nucleotide-excision repair|DNA synthesis involved in DNA repair|chromatin|euchromatin|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|angiogenesis|ovulation from ovarian follicle|fibrillar center|cellular glucose homeostasis|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|p53 binding|positive regulation of adaptive immune response|transcription coactivator activity|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|histone deacetylase activity|protein binding|nucleus|nuclear envelope|nuclear inner membrane|nucleoplasm|chromatin silencing complex|nucleolus|cytoplasm|mitochondrion|cytosol|chromatin organization|DNA methylation-dependent heterochromatin assembly|protein ADP-ribosylation|protein deacetylation|triglyceride mobilization|cellular response to DNA damage stimulus|response to oxidative stress|transforming growth factor beta receptor signaling pathway|spermatogenesis|regulation of mitotic cell cycle|muscle organ development|cell aging|protein C-terminus binding|transcription factor binding|positive regulation of cell population proliferation|cellular response to starvation|negative regulation of gene expression|regulation of centrosome duplication|positive regulation of cholesterol efflux|regulation of lipid storage|regulation of glucose metabolic process|macrophage cytokine production|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|positive regulation of macroautophagy|protein ubiquitination|histone deacetylation|PML body|NAD-dependent histone deacetylase activity|peptidyl-lysine acetylation|deacetylase activity|enzyme binding|macrophage differentiation|negative regulation of cell growth|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of prostaglandin biosynthetic process|heterochromatin assembly|protein destabilization|negative regulation of TOR signaling|regulation of endodeoxyribonuclease activity|negative regulation of NF-kappaB transcription factor activity|response to insulin|circadian regulation of gene expression|leptin-mediated signaling pathway|rDNA heterochromatin|protein deacetylase activity|regulation of smooth muscle cell apoptotic process|NAD-dependent protein deacetylase activity|peptidyl-lysine deacetylation|ESC/E(Z) complex|nuclear hormone receptor binding|cellular triglyceride homeostasis|regulation of peroxisome proliferator activated receptor signaling pathway|regulation of cell population proliferation|negative regulation of phosphorylation|histone binding|response to hydrogen peroxide|behavioral response to starvation|cholesterol homeostasis|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|HLH domain binding|bHLH transcription factor binding|negative regulation of DNA-binding transcription factor activity|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of blood vessel endothelial cell migration|response to leptin|positive regulation of MHC class II biosynthetic process|negative regulation of fat cell differentiation|positive regulation of gluconeogenesis|positive regulation of DNA repair|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of insulin receptor signaling pathway|metal ion binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|white fat cell differentiation|mitogen-activated protein kinase binding|negative regulation of helicase activity|positive regulation of smooth muscle cell differentiation|positive regulation of histone H3-K9 methylation|negative regulation of protein kinase B signaling|fatty acid homeostasis|negative regulation of androgen receptor signaling pathway|histone H3-K9 modification|cellular response to hydrogen peroxide|NAD+ binding|heterochromatin maintenance|regulation of bile acid biosynthetic process|UV-damage excision repair|histone H3 deacetylation|cellular response to tumor necrosis factor|negative regulation of histone H3-K14 acetylation|cellular response to hypoxia|cellular response to ionizing radiation|regulation of protein serine/threonine kinase activity|regulation of brown fat cell differentiation|stress-induced premature senescence|protein depropionylation|protein-propionyllysine depropionylase activity|regulation of cellular response to heat|negative regulation of histone H3-K9 trimethylation|negative regulation of neuron death|negative regulation of protein acetylation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of adipose tissue development|keratin filament binding|histone H3-K9 deacetylation|cellular response to leukemia inhibitory factor|promoter-specific chromatin binding|positive regulation of macrophage apoptotic process|negative regulation of cAMP-dependent protein kinase activity|positive regulation of cAMP-dependent protein kinase activity|negative regulation of histone H4-K16 acetylation|negative regulation of cellular response to testosterone stimulus|negative regulation of peptidyl-lysine acetylation|negative regulation of cellular senescence|positive regulation of cellular senescence" "hsa00760,hsa04068,hsa04152,hsa04211,hsa04213,hsa04218,hsa04922,hsa05031,hsa05206" Nicotinate and nicotinamide metabolism|FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Glucagon signaling pathway|Amphetamine addiction|MicroRNAs in cancer SIRT2 504.189149 520.6724118 487.7058862 0.936684708 -0.094364582 0.821005598 1 13.27137435 12.9665745 22933 sirtuin 2 "GO:0000122,GO:0000183,GO:0000781,GO:0000792,GO:0003682,GO:0003950,GO:0004407,GO:0005515,GO:0005634,GO:0005677,GO:0005694,GO:0005730,GO:0005737,GO:0005739,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005874,GO:0005886,GO:0006342,GO:0006348,GO:0006471,GO:0006476,GO:0006914,GO:0007096,GO:0008134,GO:0008270,GO:0008285,GO:0010507,GO:0010801,GO:0014065,GO:0016575,GO:0017136,GO:0021762,GO:0022011,GO:0030426,GO:0030496,GO:0031641,GO:0032436,GO:0033010,GO:0033270,GO:0033558,GO:0034599,GO:0034979,GO:0034983,GO:0035035,GO:0035729,GO:0042177,GO:0042325,GO:0042826,GO:0042903,GO:0043130,GO:0043161,GO:0043204,GO:0043209,GO:0043219,GO:0043220,GO:0043388,GO:0043491,GO:0044224,GO:0044242,GO:0045087,GO:0045599,GO:0045836,GO:0045843,GO:0045892,GO:0045944,GO:0046970,GO:0048012,GO:0048471,GO:0051301,GO:0051321,GO:0051726,GO:0051775,GO:0051781,GO:0051987,GO:0061428,GO:0061433,GO:0070403,GO:0070446,GO:0070932,GO:0070933,GO:0071219,GO:0071456,GO:0071872,GO:0072686,GO:0072687,GO:0090042,GO:0097386,GO:1900119,GO:1900195,GO:1900226,GO:1900425,GO:2000378,GO:2000777" "negative regulation of transcription by RNA polymerase II|rDNA heterochromatin assembly|chromosome, telomeric region|heterochromatin|chromatin binding|NAD+ ADP-ribosyltransferase activity|histone deacetylase activity|protein binding|nucleus|chromatin silencing complex|chromosome|nucleolus|cytoplasm|mitochondrion|centrosome|centriole|spindle|cytosol|microtubule|plasma membrane|chromatin silencing|chromatin silencing at telomere|protein ADP-ribosylation|protein deacetylation|autophagy|regulation of exit from mitosis|transcription factor binding|zinc ion binding|negative regulation of cell population proliferation|negative regulation of autophagy|negative regulation of peptidyl-threonine phosphorylation|phosphatidylinositol 3-kinase signaling|histone deacetylation|NAD-dependent histone deacetylase activity|substantia nigra development|myelination in peripheral nervous system|growth cone|midbody|regulation of myelination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|paranodal junction|paranode region of axon|protein deacetylase activity|cellular response to oxidative stress|NAD-dependent protein deacetylase activity|peptidyl-lysine deacetylation|histone acetyltransferase binding|cellular response to hepatocyte growth factor stimulus|negative regulation of protein catabolic process|regulation of phosphorylation|histone deacetylase binding|tubulin deacetylase activity|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|perikaryon|myelin sheath|lateral loop|Schmidt-Lanterman incisure|positive regulation of DNA binding|protein kinase B signaling|juxtaparanode region of axon|cellular lipid catabolic process|innate immune response|negative regulation of fat cell differentiation|positive regulation of meiotic nuclear division|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|NAD-dependent histone deacetylase activity (H4-K16 specific)|hepatocyte growth factor receptor signaling pathway|perinuclear region of cytoplasm|cell division|meiotic cell cycle|regulation of cell cycle|response to redox state|positive regulation of cell division|positive regulation of attachment of spindle microtubules to kinetochore|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to caloric restriction|NAD+ binding|negative regulation of oligodendrocyte progenitor proliferation|histone H3 deacetylation|histone H4 deacetylation|cellular response to molecule of bacterial origin|cellular response to hypoxia|cellular response to epinephrine stimulus|mitotic spindle|meiotic spindle|tubulin deacetylation|glial cell projection|positive regulation of execution phase of apoptosis|positive regulation of oocyte maturation|negative regulation of NLRP3 inflammasome complex assembly|negative regulation of defense response to bacterium|negative regulation of reactive oxygen species metabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia" hsa00760 Nicotinate and nicotinamide metabolism SIRT3 515.0594707 489.2087768 540.9101647 1.105683688 0.144938722 0.723932641 1 5.546608175 6.396970086 23410 sirtuin 3 "GO:0003950,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0006471,GO:0006476,GO:0007005,GO:0007568,GO:0008270,GO:0009060,GO:0016575,GO:0017136,GO:0019899,GO:0032024,GO:0032991,GO:0034979,GO:0034983,GO:0043565,GO:0070373,GO:0070403,GO:1901671,GO:1902553,GO:2000304,GO:2000378" NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|protein ADP-ribosylation|protein deacetylation|mitochondrion organization|aging|zinc ion binding|aerobic respiration|histone deacetylation|NAD-dependent histone deacetylase activity|enzyme binding|positive regulation of insulin secretion|protein-containing complex|NAD-dependent protein deacetylase activity|peptidyl-lysine deacetylation|sequence-specific DNA binding|negative regulation of ERK1 and ERK2 cascade|NAD+ binding|positive regulation of superoxide dismutase activity|positive regulation of catalase activity|positive regulation of ceramide biosynthetic process|negative regulation of reactive oxygen species metabolic process "hsa00760,hsa05230" Nicotinate and nicotinamide metabolism|Central carbon metabolism in cancer SIRT4 49.00539943 49.73284245 48.27795641 0.970745971 -0.042834281 0.98693431 1 1.024315992 1.037183213 23409 sirtuin 4 "GO:0000820,GO:0003950,GO:0005515,GO:0005739,GO:0005743,GO:0005759,GO:0006471,GO:0006541,GO:0006974,GO:0007005,GO:0008270,GO:0010667,GO:0034979,GO:0034983,GO:0046322,GO:0046676,GO:0046889,GO:0047708,GO:0061690,GO:0070403,GO:0071456,GO:0072350,GO:1903217,GO:1904182" regulation of glutamine family amino acid metabolic process|NAD+ ADP-ribosyltransferase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|protein ADP-ribosylation|glutamine metabolic process|cellular response to DNA damage stimulus|mitochondrion organization|zinc ion binding|negative regulation of cardiac muscle cell apoptotic process|NAD-dependent protein deacetylase activity|peptidyl-lysine deacetylation|negative regulation of fatty acid oxidation|negative regulation of insulin secretion|positive regulation of lipid biosynthetic process|biotinidase activity|lipoamidase activity|NAD+ binding|cellular response to hypoxia|tricarboxylic acid metabolic process|negative regulation of protein processing involved in protein targeting to mitochondrion|regulation of pyruvate dehydrogenase activity hsa00760 Nicotinate and nicotinamide metabolism SIRT5 167.6446463 178.6322504 156.6570422 0.876980735 -0.189382945 0.747438097 1 1.268165588 1.160063993 23408 sirtuin 5 "GO:0003950,GO:0005634,GO:0005739,GO:0005758,GO:0005759,GO:0005829,GO:0006471,GO:0006476,GO:0007005,GO:0008270,GO:0010566,GO:0034979,GO:0036046,GO:0036047,GO:0036048,GO:0036049,GO:0036054,GO:0036055,GO:0061697,GO:0061698,GO:0061699,GO:0070403,GO:2000378" NAD+ ADP-ribosyltransferase activity|nucleus|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|cytosol|protein ADP-ribosylation|protein deacetylation|mitochondrion organization|zinc ion binding|regulation of ketone biosynthetic process|NAD-dependent protein deacetylase activity|protein demalonylation|peptidyl-lysine demalonylation|protein desuccinylation|peptidyl-lysine desuccinylation|protein-malonyllysine demalonylase activity|protein-succinyllysine desuccinylase activity|protein-glutaryllysine deglutarylase activity|protein deglutarylation|peptidyl-lysine deglutarylation|NAD+ binding|negative regulation of reactive oxygen species metabolic process hsa00760 Nicotinate and nicotinamide metabolism SIRT6 256.1172839 265.9184637 246.3161041 0.926284323 -0.110472998 0.83090616 1 7.099542479 6.859470705 51548 sirtuin 6 "GO:0000122,GO:0003247,GO:0003714,GO:0003950,GO:0003956,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006471,GO:0006476,GO:0008270,GO:0010569,GO:0017136,GO:0019213,GO:0031667,GO:0031940,GO:0032206,GO:0034979,GO:0046969,GO:0061647,GO:0070403,GO:0070932,GO:0099115,GO:0120162,GO:1901485,GO:1902732,GO:1905549,GO:1905555,GO:1905564,GO:1990619" "negative regulation of transcription by RNA polymerase II|post-embryonic cardiac muscle cell growth involved in heart morphogenesis|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|NAD(P)+-protein-arginine ADP-ribosyltransferase activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|protein ADP-ribosylation|protein deacetylation|zinc ion binding|regulation of double-strand break repair via homologous recombination|NAD-dependent histone deacetylase activity|deacetylase activity|response to nutrient levels|positive regulation of chromatin silencing at telomere|positive regulation of telomere maintenance|NAD-dependent protein deacetylase activity|NAD-dependent histone deacetylase activity (H3-K9 specific)|histone H3-K9 modification|NAD+ binding|histone H3 deacetylation|chromosome, subtelomeric region|positive regulation of cold-induced thermogenesis|positive regulation of transcription factor catabolic process|positive regulation of chondrocyte proliferation|positive regulation of subtelomeric heterochromatin assembly|positive regulation of blood vessel branching|positive regulation of vascular endothelial cell proliferation|histone H3-K9 deacetylation" "hsa00760,hsa04714,hsa05230" Nicotinate and nicotinamide metabolism|Thermogenesis|Central carbon metabolism in cancer other SIRT7 313.31656 336.9653815 289.6677385 0.859636492 -0.218201368 0.643444531 1 4.932401107 4.42271709 51547 sirtuin 7 "GO:0000122,GO:0000785,GO:0001649,GO:0003682,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005731,GO:0005737,GO:0006111,GO:0006281,GO:0006282,GO:0006476,GO:0006974,GO:0007072,GO:0007129,GO:0009303,GO:0010529,GO:0010821,GO:0016570,GO:0016607,GO:0019213,GO:0031397,GO:0034979,GO:0035861,GO:0036049,GO:0036055,GO:0045944,GO:0046825,GO:0046872,GO:0061697,GO:0061698,GO:0061699,GO:0062176,GO:0070403,GO:0070932,GO:0070933,GO:0097372,GO:0106230,GO:0106231,GO:1901836,GO:1990258,GO:2000234,GO:2001032" negative regulation of transcription by RNA polymerase II|chromatin|osteoblast differentiation|chromatin binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|nucleolus|nucleolus organizer region|cytoplasm|regulation of gluconeogenesis|DNA repair|regulation of DNA repair|protein deacetylation|cellular response to DNA damage stimulus|positive regulation of transcription involved in exit from mitosis|homologous chromosome pairing at meiosis|rRNA transcription|negative regulation of transposition|regulation of mitochondrion organization|histone modification|nuclear speck|deacetylase activity|negative regulation of protein ubiquitination|NAD-dependent protein deacetylase activity|site of double-strand break|peptidyl-lysine desuccinylation|protein-succinyllysine desuccinylase activity|positive regulation of transcription by RNA polymerase II|regulation of protein export from nucleus|metal ion binding|protein-glutaryllysine deglutarylase activity|protein deglutarylation|peptidyl-lysine deglutarylation|R-loop disassembly|NAD+ binding|histone H3 deacetylation|histone H4 deacetylation|NAD-dependent histone deacetylase activity (H3-K18 specific)|protein depropionylation|protein-propionyllysine depropionylase activity|regulation of transcription of nucleolar large rRNA by RNA polymerase I|histone glutamine methylation|positive regulation of rRNA processing|regulation of double-strand break repair via nonhomologous end joining hsa00760 Nicotinate and nicotinamide metabolism SIVA1 1054.364562 952.0286983 1156.700425 1.214984829 0.280938299 0.421537105 1 28.48015063 36.09350572 10572 SIVA1 apoptosis inducing factor "GO:0001618,GO:0005164,GO:0005175,GO:0005515,GO:0005654,GO:0005737,GO:0046718,GO:0046872,GO:0097191" virus receptor activity|tumor necrosis factor receptor binding|CD27 receptor binding|protein binding|nucleoplasm|cytoplasm|viral entry into host cell|metal ion binding|extrinsic apoptotic signaling pathway hsa04115 p53 signaling pathway SIX1 374.7943872 296.3671428 453.2216316 1.529257351 0.612831211 0.165829315 1 3.736606985 5.960379713 6495 SIX homeobox 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001223,GO:0001228,GO:0001657,GO:0001658,GO:0001759,GO:0001822,GO:0003151,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0006355,GO:0006357,GO:0006915,GO:0007389,GO:0007519,GO:0007605,GO:0008582,GO:0014842,GO:0014857,GO:0021610,GO:0030855,GO:0030878,GO:0030910,GO:0032880,GO:0034504,GO:0035909,GO:0042472,GO:0042474,GO:0043524,GO:0043565,GO:0045664,GO:0045893,GO:0045944,GO:0048538,GO:0048665,GO:0048699,GO:0048701,GO:0048704,GO:0048741,GO:0048839,GO:0050678,GO:0051451,GO:0060037,GO:0061055,GO:0061197,GO:0061551,GO:0071599,GO:0072075,GO:0072095,GO:0072107,GO:0072172,GO:0072193,GO:0072513,GO:0090103,GO:0090190,GO:0090336,GO:1905243,GO:1990837,GO:2000729,GO:2001014" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|ureteric bud development|branching involved in ureteric bud morphogenesis|organ induction|kidney development|outflow tract morphogenesis|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|apoptotic process|pattern specification process|skeletal muscle tissue development|sensory perception of sound|regulation of synaptic growth at neuromuscular junction|regulation of skeletal muscle satellite cell proliferation|regulation of skeletal muscle cell proliferation|facial nerve morphogenesis|epithelial cell differentiation|thyroid gland development|olfactory placode formation|regulation of protein localization|protein localization to nucleus|aorta morphogenesis|inner ear morphogenesis|middle ear morphogenesis|negative regulation of neuron apoptotic process|sequence-specific DNA binding|regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thymus development|neuron fate specification|generation of neurons|embryonic cranial skeleton morphogenesis|embryonic skeletal system morphogenesis|skeletal muscle fiber development|inner ear development|regulation of epithelial cell proliferation|myoblast migration|pharyngeal system development|myotome development|fungiform papilla morphogenesis|trigeminal ganglion development|otic vesicle development|metanephric mesenchyme development|regulation of branch elongation involved in ureteric bud branching|positive regulation of ureteric bud formation|mesonephric tubule formation|ureter smooth muscle cell differentiation|positive regulation of secondary heart field cardioblast proliferation|cochlea morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of brown fat cell differentiation|cellular response to 3,3',5-triiodo-L-thyronine|sequence-specific double-stranded DNA binding|positive regulation of mesenchymal cell proliferation involved in ureter development|regulation of skeletal muscle cell differentiation" hsa05202 Transcriptional misregulation in cancer Homeobox SIX2 7.434020452 3.044867905 11.823173 3.882983882 1.957165719 0.236388736 1 0.064121338 0.259707262 10736 SIX homeobox 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001822,GO:0002062,GO:0003337,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0006606,GO:0007501,GO:0008134,GO:0008283,GO:0009653,GO:0009948,GO:0016477,GO:0030278,GO:0032330,GO:0042474,GO:0044877,GO:0045596,GO:0045944,GO:0048557,GO:0048701,GO:0072006,GO:0072028,GO:0072038,GO:0072137,GO:0072161,GO:0090189,GO:0097168,GO:1902732,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|kidney development|chondrocyte differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|protein import into nucleus|mesodermal cell fate specification|transcription factor binding|cell population proliferation|anatomical structure morphogenesis|anterior/posterior axis specification|cell migration|regulation of ossification|regulation of chondrocyte differentiation|middle ear morphogenesis|protein-containing complex binding|negative regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|embryonic digestive tract morphogenesis|embryonic cranial skeleton morphogenesis|nephron development|nephron morphogenesis|mesenchymal stem cell maintenance involved in nephron morphogenesis|condensed mesenchymal cell proliferation|mesenchymal cell differentiation involved in kidney development|regulation of branching involved in ureteric bud morphogenesis|mesenchymal stem cell proliferation|positive regulation of chondrocyte proliferation|sequence-specific double-stranded DNA binding" Homeobox SIX4 798.0433963 806.8899949 789.1967977 0.978072355 -0.031986899 0.934166189 1 6.535444059 6.667484508 51804 SIX homeobox 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0007519,GO:0008582,GO:0008584,GO:0009653,GO:0030238,GO:0030910,GO:0032880,GO:0034504,GO:0042472,GO:0043066,GO:0043524,GO:0043586,GO:0045214,GO:0045892,GO:0045893,GO:0045944,GO:0046661,GO:0048538,GO:0048699,GO:0048701,GO:0050678,GO:0051451,GO:0060037,GO:0061055,GO:0061197,GO:0061551,GO:0072075,GO:0072095,GO:0072107,GO:0090190,GO:0098528,GO:1902725,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|skeletal muscle tissue development|regulation of synaptic growth at neuromuscular junction|male gonad development|anatomical structure morphogenesis|male sex determination|olfactory placode formation|regulation of protein localization|protein localization to nucleus|inner ear morphogenesis|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|tongue development|sarcomere organization|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|male sex differentiation|thymus development|generation of neurons|embryonic cranial skeleton morphogenesis|regulation of epithelial cell proliferation|myoblast migration|pharyngeal system development|myotome development|fungiform papilla morphogenesis|trigeminal ganglion development|metanephric mesenchyme development|regulation of branch elongation involved in ureteric bud branching|positive regulation of ureteric bud formation|positive regulation of branching involved in ureteric bud morphogenesis|skeletal muscle fiber differentiation|negative regulation of satellite cell differentiation|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer SIX5 666.9992695 671.9008511 662.0976879 0.985409807 -0.021204265 0.95994079 1 10.17625831 10.45974103 147912 SIX homeobox 5 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002088,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0007286,GO:0045892,GO:0045944,GO:1902723" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|lens development in camera-type eye|protein binding|nucleus|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|spermatid development|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of skeletal muscle satellite cell proliferation" Homeobox SKA1 740.8401608 600.8539333 880.8263884 1.465957597 0.551843374 0.13950716 1 10.68133803 16.33288851 220134 spindle and kinetochore associated complex subunit 1 "GO:0000278,GO:0000940,GO:0005515,GO:0005829,GO:0005876,GO:0007059,GO:0008017,GO:0015630,GO:0031110,GO:0051301,GO:0072686" mitotic cell cycle|condensed chromosome outer kinetochore|protein binding|cytosol|spindle microtubule|chromosome segregation|microtubule binding|microtubule cytoskeleton|regulation of microtubule polymerization or depolymerization|cell division|mitotic spindle SKA2 1400.651107 1185.468571 1615.833643 1.363033726 0.446821259 0.181815501 1 19.98661819 28.41592826 348235 spindle and kinetochore associated complex subunit 2 "GO:0000278,GO:0000940,GO:0005515,GO:0005829,GO:0005876,GO:0007059,GO:0008017,GO:0031110,GO:0051301" mitotic cell cycle|condensed chromosome outer kinetochore|protein binding|cytosol|spindle microtubule|chromosome segregation|microtubule binding|regulation of microtubule polymerization or depolymerization|cell division SKA3 636.3224606 662.7662473 609.8786738 0.92020177 -0.119977864 0.758636034 1 11.5907363 11.12525616 221150 spindle and kinetochore associated complex subunit 3 "GO:0000278,GO:0000776,GO:0000940,GO:0005515,GO:0005813,GO:0005829,GO:0005876,GO:0007059,GO:0031110,GO:0051301,GO:0072686" mitotic cell cycle|kinetochore|condensed chromosome outer kinetochore|protein binding|centrosome|cytosol|spindle microtubule|chromosome segregation|regulation of microtubule polymerization or depolymerization|cell division|mitotic spindle SKAP2 715.5686982 759.1870643 671.9503321 0.885091914 -0.176100812 0.64125912 1 5.285243513 4.879432392 8935 src kinase associated phosphoprotein 2 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0008285,GO:0042113,GO:0065003" protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|signal transduction|negative regulation of cell population proliferation|B cell activation|protein-containing complex assembly hsa05135 Yersinia infection SKI 2153.777136 2154.751521 2152.80275 0.999095594 -0.001305373 0.998414597 1 9.866247448 10.28193791 6497 SKI proto-oncogene "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001843,GO:0002089,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0006351,GO:0007179,GO:0008270,GO:0008285,GO:0009948,GO:0010626,GO:0014902,GO:0016604,GO:0016605,GO:0017053,GO:0019901,GO:0019904,GO:0021772,GO:0022011,GO:0030177,GO:0030326,GO:0030509,GO:0030512,GO:0030514,GO:0031064,GO:0031625,GO:0032926,GO:0032991,GO:0035019,GO:0042802,GO:0043010,GO:0043388,GO:0043585,GO:0045668,GO:0045944,GO:0046332,GO:0046811,GO:0048147,GO:0048593,GO:0048741,GO:0048870,GO:0060021,GO:0060041,GO:0060325,GO:0060349,GO:0060395,GO:0070491" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|neural tube closure|lens morphogenesis in camera-type eye|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|centrosome|transcription, DNA-templated|transforming growth factor beta receptor signaling pathway|zinc ion binding|negative regulation of cell population proliferation|anterior/posterior axis specification|negative regulation of Schwann cell proliferation|myotube differentiation|nuclear body|PML body|transcription repressor complex|protein kinase binding|protein domain specific binding|olfactory bulb development|myelination in peripheral nervous system|positive regulation of Wnt signaling pathway|embryonic limb morphogenesis|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of histone deacetylation|ubiquitin protein ligase binding|negative regulation of activin receptor signaling pathway|protein-containing complex|somatic stem cell population maintenance|identical protein binding|camera-type eye development|positive regulation of DNA binding|nose morphogenesis|negative regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|SMAD binding|histone deacetylase inhibitor activity|negative regulation of fibroblast proliferation|camera-type eye morphogenesis|skeletal muscle fiber development|cell motility|roof of mouth development|retina development in camera-type eye|face morphogenesis|bone morphogenesis|SMAD protein signal transduction|repressing transcription factor binding" other SKIDA1 11.03090367 13.19442759 8.867379749 0.672054903 -0.573348998 0.714667397 1 0.07168539 0.050251767 387640 SKI/DACH domain containing 1 SKIL 1308.488306 1317.412847 1299.563765 0.986451414 -0.0196801 0.955938605 1 9.081572498 9.344427172 6498 SKI like proto-oncogene "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001669,GO:0001825,GO:0002260,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0007050,GO:0007179,GO:0007283,GO:0030512,GO:0030514,GO:0032991,GO:0034097,GO:0045596,GO:0046332,GO:0050772,GO:0070306,GO:1902043,GO:1902231" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|acrosomal vesicle|blastocyst formation|lymphocyte homeostasis|chromatin binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|cell cycle arrest|transforming growth factor beta receptor signaling pathway|spermatogenesis|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|protein-containing complex|response to cytokine|negative regulation of cell differentiation|SMAD binding|positive regulation of axonogenesis|lens fiber cell differentiation|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage" hsa04550 Signaling pathways regulating pluripotency of stem cells SKIV2L 973.4986506 946.9539185 1000.043383 1.056063408 0.07869646 0.826481458 1 12.41518905 13.67600535 6499 Ski2 like RNA helicase "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006401,GO:0043928,GO:0055087,GO:0070478" "RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|cytosol|RNA catabolic process|exonucleolytic catabolism of deadenylated mRNA|Ski complex|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay" hsa03018 RNA degradation SKOR1 9.015837508 10.14955968 7.882115332 0.776596776 -0.364762376 0.872363928 1 0.137517226 0.111395749 390598 SKI family transcriptional corepressor 1 "GO:0000122,GO:0000978,GO:0000981,GO:0005634,GO:0005667,GO:0006355,GO:0030425,GO:0030514,GO:0043025,GO:0046332,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|transcription regulator complex|regulation of transcription, DNA-templated|dendrite|negative regulation of BMP signaling pathway|neuronal cell body|SMAD binding|sequence-specific double-stranded DNA binding" SKP1 3306.917795 3157.528018 3456.307573 1.094624514 0.130436072 0.682152422 1 15.87744788 18.12849685 6500 S-phase kinase associated protein 1 "GO:0000086,GO:0000209,GO:0002223,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006879,GO:0008013,GO:0010265,GO:0010972,GO:0016032,GO:0016055,GO:0016567,GO:0019005,GO:0019904,GO:0031146,GO:0031467,GO:0031519,GO:0035518,GO:0038061,GO:0038095,GO:0043687,GO:0050852,GO:0051403,GO:0051457,GO:0070498,GO:0070936,GO:0097602,GO:1901990,GO:1904668,GO:1990444,GO:1990756" G2/M transition of mitotic cell cycle|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|cellular iron ion homeostasis|beta-catenin binding|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|viral process|Wnt signaling pathway|protein ubiquitination|SCF ubiquitin ligase complex|protein domain specific binding|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Cul7-RING ubiquitin ligase complex|PcG protein complex|histone H2A monoubiquitination|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|post-translational protein modification|T cell receptor signaling pathway|stress-activated MAPK cascade|maintenance of protein location in nucleus|interleukin-1-mediated signaling pathway|protein K48-linked ubiquitination|cullin family protein binding|regulation of mitotic cell cycle phase transition|positive regulation of ubiquitin protein ligase activity|F-box domain binding|ubiquitin ligase-substrate adaptor activity "hsa04110,hsa04114,hsa04120,hsa04141,hsa04310,hsa04350,hsa04710,hsa05131,hsa05132,hsa05170,hsa05200" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Wnt signaling pathway|TGF-beta signaling pathway|Circadian rhythm|Shigellosis|Salmonella infection|Human immunodeficiency virus 1 infection|Pathways in cancer SKP2 840.7606216 898.236032 783.2852112 0.872026041 -0.197556876 0.588348465 1 7.540607697 6.858856729 6502 S-phase kinase associated protein 2 "GO:0000082,GO:0000086,GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0016032,GO:0016579,GO:0019005,GO:0031146,GO:0042802,GO:0042981,GO:0043161,GO:0043687,GO:0045087,GO:0051607,GO:0051726,GO:0070936" G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|viral process|protein deubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|innate immune response|defense response to virus|regulation of cell cycle|protein K48-linked ubiquitination "hsa04068,hsa04110,hsa04120,hsa04150,hsa05169,hsa05200,hsa05203,hsa05222" FoxO signaling pathway|Cell cycle|Ubiquitin mediated proteolysis|mTOR signaling pathway|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer SLA2 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.044959714 0 84174 Src like adaptor 2 "GO:0000122,GO:0005515,GO:0005654,GO:0005737,GO:0005770,GO:0005794,GO:0005886,GO:0005942,GO:0010008,GO:0019724,GO:0035591,GO:0042110,GO:0043231,GO:0043551,GO:0046854,GO:0046935,GO:0047485,GO:0050776,GO:0050849,GO:0050851,GO:0050860" negative regulation of transcription by RNA polymerase II|protein binding|nucleoplasm|cytoplasm|late endosome|Golgi apparatus|plasma membrane|phosphatidylinositol 3-kinase complex|endosome membrane|B cell mediated immunity|signaling adaptor activity|T cell activation|intracellular membrane-bounded organelle|regulation of phosphatidylinositol 3-kinase activity|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|protein N-terminus binding|regulation of immune response|negative regulation of calcium-mediated signaling|antigen receptor-mediated signaling pathway|negative regulation of T cell receptor signaling pathway SLAIN1 91.68080903 104.5404647 78.82115332 0.753977453 -0.407406714 0.56518393 1 1.488084807 1.170312843 122060 SLAIN motif family member 1 "GO:0005515,GO:0005737,GO:0005856" protein binding|cytoplasm|cytoskeleton SLAIN2 913.8901534 946.9539185 880.8263884 0.930168165 -0.104436531 0.772752407 1 7.719278178 7.489521866 57606 SLAIN motif family member 2 "GO:0005515,GO:0005813,GO:0005829,GO:0007020,GO:0015630,GO:0031116,GO:0031122,GO:0035371" protein binding|centrosome|cytosol|microtubule nucleation|microtubule cytoskeleton|positive regulation of microtubule polymerization|cytoplasmic microtubule organization|microtubule plus-end SLBP 1158.803828 1120.511389 1197.096266 1.068348147 0.09538186 0.783352859 1 31.35356294 34.93941514 7884 stem-loop binding protein "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006369,GO:0006398,GO:0006406,GO:0008334,GO:0042802,GO:0051028,GO:0071204,GO:0071207,GO:0071208,GO:1990904" RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|termination of RNA polymerase II transcription|mRNA 3'-end processing by stem-loop binding and cleavage|mRNA export from nucleus|histone mRNA metabolic process|identical protein binding|mRNA transport|histone pre-mRNA 3'end processing complex|histone pre-mRNA stem-loop binding|histone pre-mRNA DCP binding|ribonucleoprotein complex SLC10A3 680.7363098 634.3474802 727.1251394 1.146256842 0.196930345 0.605945959 1 9.852027608 11.77940871 8273 solute carrier family 10 member 3 "GO:0008508,GO:0015721,GO:0016021,GO:0055085" bile acid:sodium symporter activity|bile acid and bile salt transport|integral component of membrane|transmembrane transport SLC10A5 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.143988625 0.072898689 347051 solute carrier family 10 member 5 "GO:0006814,GO:0008508,GO:0015721,GO:0016021,GO:0055085" sodium ion transport|bile acid:sodium symporter activity|bile acid and bile salt transport|integral component of membrane|transmembrane transport SLC10A7 130.1776286 143.1087915 117.2464656 0.81928206 -0.28756787 0.64973571 1 0.565098662 0.48291829 84068 solute carrier family 10 member 7 "GO:0000139,GO:0005783,GO:0005789,GO:0005794,GO:0005797,GO:0005801,GO:0005802,GO:0005886,GO:0006814,GO:0006874,GO:0015125,GO:0015293,GO:0015721,GO:0016021,GO:0030210,GO:0031226,GO:0034436,GO:0048193,GO:0055085,GO:0060348" Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|Golgi medial cisterna|cis-Golgi network|trans-Golgi network|plasma membrane|sodium ion transport|cellular calcium ion homeostasis|bile acid transmembrane transporter activity|symporter activity|bile acid and bile salt transport|integral component of membrane|heparin biosynthetic process|intrinsic component of plasma membrane|glycoprotein transport|Golgi vesicle transport|transmembrane transport|bone development SLC11A1 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.06135586 0.024850639 6556 solute carrier family 11 member 1 "GO:0001818,GO:0001819,GO:0002309,GO:0002606,GO:0002827,GO:0005381,GO:0005384,GO:0005764,GO:0005770,GO:0005886,GO:0005887,GO:0006826,GO:0006828,GO:0006876,GO:0006879,GO:0006909,GO:0006954,GO:0007035,GO:0009617,GO:0010628,GO:0015086,GO:0015707,GO:0019730,GO:0030670,GO:0031902,GO:0032147,GO:0032496,GO:0032729,GO:0034341,GO:0034755,GO:0042060,GO:0042116,GO:0042742,GO:0042803,GO:0042832,GO:0043312,GO:0045342,GO:0045454,GO:0045730,GO:0045944,GO:0046915,GO:0048002,GO:0048255,GO:0050766,GO:0050829,GO:0051139,GO:0055072,GO:0060586,GO:0070574,GO:0070821,GO:0070839,GO:0071421,GO:0101003,GO:1902023" negative regulation of cytokine production|positive regulation of cytokine production|T cell proliferation involved in immune response|positive regulation of dendritic cell antigen processing and presentation|positive regulation of T-helper 1 type immune response|iron ion transmembrane transporter activity|manganese ion transmembrane transporter activity|lysosome|late endosome|plasma membrane|integral component of plasma membrane|iron ion transport|manganese ion transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|phagocytosis|inflammatory response|vacuolar acidification|response to bacterium|positive regulation of gene expression|cadmium ion transmembrane transporter activity|nitrite transport|antimicrobial humoral response|phagocytic vesicle membrane|late endosome membrane|activation of protein kinase activity|response to lipopolysaccharide|positive regulation of interferon-gamma production|response to interferon-gamma|iron ion transmembrane transport|wound healing|macrophage activation|defense response to bacterium|protein homodimerization activity|defense response to protozoan|neutrophil degranulation|MHC class II biosynthetic process|cell redox homeostasis|respiratory burst|positive regulation of transcription by RNA polymerase II|transition metal ion transmembrane transporter activity|antigen processing and presentation of peptide antigen|mRNA stabilization|positive regulation of phagocytosis|defense response to Gram-negative bacterium|metal ion:proton antiporter activity|iron ion homeostasis|multicellular organismal iron ion homeostasis|cadmium ion transmembrane transport|tertiary granule membrane|divalent metal ion export|manganese ion transmembrane transport|ficolin-1-rich granule membrane|L-arginine transport hsa04142 Lysosome SLC11A2 2329.630504 2355.712803 2303.548206 0.977856131 -0.032305874 0.920823163 1 15.78364109 16.09896994 4891 solute carrier family 11 member 2 "GO:0001666,GO:0005375,GO:0005381,GO:0005384,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005765,GO:0005769,GO:0005773,GO:0005886,GO:0005887,GO:0006783,GO:0006824,GO:0006825,GO:0006826,GO:0006828,GO:0006879,GO:0007611,GO:0009986,GO:0010039,GO:0015086,GO:0015087,GO:0015093,GO:0015094,GO:0015099,GO:0015295,GO:0015692,GO:0016020,GO:0016324,GO:0031410,GO:0031526,GO:0031902,GO:0033212,GO:0034755,GO:0035434,GO:0035444,GO:0045177,GO:0045178,GO:0046870,GO:0046915,GO:0048471,GO:0048813,GO:0048821,GO:0055037,GO:0060586,GO:0070574,GO:0070826,GO:0071421,GO:1902600,GO:1903561" response to hypoxia|copper ion transmembrane transporter activity|iron ion transmembrane transporter activity|manganese ion transmembrane transporter activity|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|lysosomal membrane|early endosome|vacuole|plasma membrane|integral component of plasma membrane|heme biosynthetic process|cobalt ion transport|copper ion transport|iron ion transport|manganese ion transport|cellular iron ion homeostasis|learning or memory|cell surface|response to iron ion|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|nickel cation transmembrane transporter activity|solute:proton symporter activity|lead ion transport|membrane|apical plasma membrane|cytoplasmic vesicle|brush border membrane|late endosome membrane|iron import into cell|iron ion transmembrane transport|copper ion transmembrane transport|nickel cation transmembrane transport|apical part of cell|basal part of cell|cadmium ion binding|transition metal ion transmembrane transporter activity|perinuclear region of cytoplasm|dendrite morphogenesis|erythrocyte development|recycling endosome|multicellular organismal iron ion homeostasis|cadmium ion transmembrane transport|paraferritin complex|manganese ion transmembrane transport|proton transmembrane transport|extracellular vesicle "hsa04142,hsa04216,hsa04978" Lysosome|Ferroptosis|Mineral absorption SLC12A2 531.7508205 653.6316436 409.8699973 0.62706572 -0.673311441 0.094703301 1 3.042939321 1.990317134 6558 solute carrier family 12 member 2 "GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0006811,GO:0006883,GO:0006884,GO:0006972,GO:0007214,GO:0007568,GO:0008511,GO:0008519,GO:0009925,GO:0010818,GO:0015079,GO:0015377,GO:0015379,GO:0015696,GO:0016020,GO:0016324,GO:0016328,GO:0019901,GO:0030007,GO:0030321,GO:0030644,GO:0030659,GO:0031253,GO:0035633,GO:0035725,GO:0035865,GO:0042995,GO:0043005,GO:0043025,GO:0044297,GO:0044298,GO:0045795,GO:0046873,GO:0051087,GO:0051879,GO:0055064,GO:0055075,GO:0055078,GO:0061044,GO:0070062,GO:0070634,GO:0071944,GO:0072488,GO:0089717,GO:0098658,GO:0098659,GO:0098719,GO:0150003,GO:0150104,GO:1902476,GO:1903561,GO:1904450,GO:1904464,GO:1990573,GO:1990869" protein binding|cytosol|plasma membrane|integral component of plasma membrane|ion transport|cellular sodium ion homeostasis|cell volume homeostasis|hyperosmotic response|gamma-aminobutyric acid signaling pathway|aging|sodium:potassium:chloride symporter activity|ammonium transmembrane transporter activity|basal plasma membrane|T cell chemotaxis|potassium ion transmembrane transporter activity|cation:chloride symporter activity|potassium:chloride symporter activity|ammonium transport|membrane|apical plasma membrane|lateral plasma membrane|protein kinase binding|cellular potassium ion homeostasis|transepithelial chloride transport|cellular chloride ion homeostasis|cytoplasmic vesicle membrane|cell projection membrane|maintenance of blood-brain barrier|sodium ion transmembrane transport|cellular response to potassium ion|cell projection|neuron projection|neuronal cell body|cell body|cell body membrane|positive regulation of cell volume|metal ion transmembrane transporter activity|chaperone binding|Hsp90 protein binding|chloride ion homeostasis|potassium ion homeostasis|sodium ion homeostasis|negative regulation of vascular wound healing|extracellular exosome|transepithelial ammonium transport|cell periphery|ammonium transmembrane transport|spanning component of membrane|inorganic anion import across plasma membrane|inorganic cation import across plasma membrane|sodium ion import across plasma membrane|regulation of spontaneous synaptic transmission|transport across blood-brain barrier|chloride transmembrane transport|extracellular vesicle|positive regulation of aspartate secretion|regulation of matrix metallopeptidase secretion|potassium ion import across plasma membrane|cellular response to chemokine "hsa04970,hsa04972,hsa05110" Salivary secretion|Pancreatic secretion|Vibrio cholerae infection SLC12A4 1271.464186 975.3726856 1567.555687 1.607135108 0.684491218 0.044047829 0.952191822 10.13940591 16.99733476 6560 solute carrier family 12 member 4 "GO:0005515,GO:0005765,GO:0005886,GO:0005887,GO:0006811,GO:0006884,GO:0007268,GO:0008519,GO:0015379,GO:0016020,GO:0019901,GO:0045202,GO:0055064,GO:0055075,GO:0140157,GO:1902476,GO:1990573" protein binding|lysosomal membrane|plasma membrane|integral component of plasma membrane|ion transport|cell volume homeostasis|chemical synaptic transmission|ammonium transmembrane transporter activity|potassium:chloride symporter activity|membrane|protein kinase binding|synapse|chloride ion homeostasis|potassium ion homeostasis|ammonium import across plasma membrane|chloride transmembrane transport|potassium ion import across plasma membrane SLC12A6 795.7517036 717.5738696 873.9295375 1.217894874 0.284389608 0.439964294 1 3.968397581 5.041281034 9990 solute carrier family 12 member 6 "GO:0001525,GO:0005886,GO:0005887,GO:0006811,GO:0006884,GO:0007268,GO:0008519,GO:0015379,GO:0016021,GO:0016323,GO:0045202,GO:0055064,GO:0055075,GO:0071477,GO:0140157,GO:1902476,GO:1990573" angiogenesis|plasma membrane|integral component of plasma membrane|ion transport|cell volume homeostasis|chemical synaptic transmission|ammonium transmembrane transporter activity|potassium:chloride symporter activity|integral component of membrane|basolateral plasma membrane|synapse|chloride ion homeostasis|potassium ion homeostasis|cellular hypotonic salinity response|ammonium import across plasma membrane|chloride transmembrane transport|potassium ion import across plasma membrane SLC12A7 969.0515988 743.9627248 1194.140473 1.605107935 0.682670314 0.054548107 1 5.735020924 9.601855771 10723 solute carrier family 12 member 7 "GO:0005886,GO:0005887,GO:0006811,GO:0006884,GO:0007268,GO:0008519,GO:0015379,GO:0019901,GO:0032991,GO:0045202,GO:0055064,GO:0055075,GO:0140157,GO:1902476,GO:1990573" plasma membrane|integral component of plasma membrane|ion transport|cell volume homeostasis|chemical synaptic transmission|ammonium transmembrane transporter activity|potassium:chloride symporter activity|protein kinase binding|protein-containing complex|synapse|chloride ion homeostasis|potassium ion homeostasis|ammonium import across plasma membrane|chloride transmembrane transport|potassium ion import across plasma membrane hsa04966 Collecting duct acid secretion SLC12A8 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.044186767 0.014913944 84561 solute carrier family 12 member 8 "GO:0005515,GO:0006884,GO:0015379,GO:0016021,GO:0055064,GO:0055075,GO:1902476,GO:1990573" protein binding|cell volume homeostasis|potassium:chloride symporter activity|integral component of membrane|chloride ion homeostasis|potassium ion homeostasis|chloride transmembrane transport|potassium ion import across plasma membrane SLC12A9 623.9499939 625.2128765 622.6871113 0.995960152 -0.005840074 0.992682961 1 8.396930941 8.723253106 56996 solute carrier family 12 member 9 "GO:0005886,GO:0006884,GO:0015377,GO:0015379,GO:0016021,GO:0055064,GO:0055075,GO:0070062,GO:1902476,GO:1990573" plasma membrane|cell volume homeostasis|cation:chloride symporter activity|potassium:chloride symporter activity|integral component of membrane|chloride ion homeostasis|potassium ion homeostasis|extracellular exosome|chloride transmembrane transport|potassium ion import across plasma membrane SLC13A3 73.47098471 72.06187375 74.88009566 1.039108363 0.055346113 0.960864954 1 0.863216577 0.935613633 64849 solute carrier family 13 member 3 "GO:0005310,GO:0005515,GO:0005886,GO:0006814,GO:0006835,GO:0015137,GO:0015139,GO:0015141,GO:0015362,GO:0015742,GO:0015746,GO:0016021,GO:0016323,GO:0017153,GO:0034634,GO:0034775,GO:0070062,GO:0071422,GO:0098656,GO:0150104" dicarboxylic acid transmembrane transporter activity|protein binding|plasma membrane|sodium ion transport|dicarboxylic acid transport|citrate transmembrane transporter activity|alpha-ketoglutarate transmembrane transporter activity|succinate transmembrane transporter activity|high-affinity sodium:dicarboxylate symporter activity|alpha-ketoglutarate transport|citrate transport|integral component of membrane|basolateral plasma membrane|sodium:dicarboxylate symporter activity|glutathione transmembrane transporter activity|glutathione transmembrane transport|extracellular exosome|succinate transmembrane transport|anion transmembrane transport|transport across blood-brain barrier SLC14A1 13.61283092 21.31407534 5.911586499 0.277355992 -1.850189203 0.151666554 1 0.194046868 0.056138411 6563 solute carrier family 14 member 1 (Kidd blood group) "GO:0005372,GO:0005886,GO:0005887,GO:0006833,GO:0015265,GO:0015840,GO:0016323,GO:0055085,GO:0071918" water transmembrane transporter activity|plasma membrane|integral component of plasma membrane|water transport|urea channel activity|urea transport|basolateral plasma membrane|transmembrane transport|urea transmembrane transport SLC15A1 10.03079348 12.17947162 7.882115332 0.64716398 -0.627796782 0.697619478 1 0.197454312 0.133289792 6564 solute carrier family 15 member 1 "GO:0005427,GO:0005886,GO:0005887,GO:0005903,GO:0006811,GO:0015031,GO:0015333,GO:0016324,GO:0042937,GO:0071916,GO:0089717,GO:0140206,GO:0140207,GO:1902600" proton-dependent oligopeptide secondary active transmembrane transporter activity|plasma membrane|integral component of plasma membrane|brush border|ion transport|protein transport|peptide:proton symporter activity|apical plasma membrane|tripeptide transmembrane transporter activity|dipeptide transmembrane transporter activity|spanning component of membrane|dipeptide import across plasma membrane|tripeptide import across plasma membrane|proton transmembrane transport hsa04974 Protein digestion and absorption SLC15A2 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.034802938 0.035240124 6565 solute carrier family 15 member 2 "GO:0005515,GO:0005886,GO:0005887,GO:0006811,GO:0015031,GO:0015333,GO:0015835,GO:0016324,GO:0042908,GO:0042938,GO:0044214,GO:0045087,GO:0070062,GO:0070293,GO:0070424,GO:0071916,GO:0089717,GO:0140206,GO:0150104,GO:1902600,GO:1990961" protein binding|plasma membrane|integral component of plasma membrane|ion transport|protein transport|peptide:proton symporter activity|peptidoglycan transport|apical plasma membrane|xenobiotic transport|dipeptide transport|spanning component of plasma membrane|innate immune response|extracellular exosome|renal absorption|regulation of nucleotide-binding oligomerization domain containing signaling pathway|dipeptide transmembrane transporter activity|spanning component of membrane|dipeptide import across plasma membrane|transport across blood-brain barrier|proton transmembrane transport|xenobiotic detoxification by transmembrane export across the plasma membrane SLC15A3 167.3356066 123.8246281 210.8465851 1.702783915 0.767895368 0.179726587 1 2.548265172 4.526057714 51296 solute carrier family 15 member 3 "GO:0005515,GO:0005765,GO:0006811,GO:0010008,GO:0015031,GO:0015293,GO:0015647,GO:0015835,GO:0016021,GO:0043231,GO:0045087,GO:0070434,GO:0071916,GO:0140206" protein binding|lysosomal membrane|ion transport|endosome membrane|protein transport|symporter activity|peptidoglycan transmembrane transporter activity|peptidoglycan transport|integral component of membrane|intracellular membrane-bounded organelle|innate immune response|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|dipeptide transmembrane transporter activity|dipeptide import across plasma membrane SLC15A4 863.9143354 898.236032 829.5926387 0.923579782 -0.114691503 0.753487456 1 11.79784394 11.3656164 121260 solute carrier family 15 member 4 "GO:0005290,GO:0005515,GO:0005765,GO:0005886,GO:0006811,GO:0015031,GO:0015333,GO:0015647,GO:0015817,GO:0015835,GO:0031303,GO:0031901,GO:0033023,GO:0034157,GO:0034161,GO:0034165,GO:0035579,GO:0036020,GO:0043312,GO:0045087,GO:0045089,GO:0048302,GO:0070424,GO:0070430,GO:0070434,GO:0071916,GO:0089708,GO:0140206,GO:1902600,GO:1905103" L-histidine transmembrane transporter activity|protein binding|lysosomal membrane|plasma membrane|ion transport|protein transport|peptide:proton symporter activity|peptidoglycan transmembrane transporter activity|histidine transport|peptidoglycan transport|integral component of endosome membrane|early endosome membrane|mast cell homeostasis|positive regulation of toll-like receptor 7 signaling pathway|positive regulation of toll-like receptor 8 signaling pathway|positive regulation of toll-like receptor 9 signaling pathway|specific granule membrane|endolysosome membrane|neutrophil degranulation|innate immune response|positive regulation of innate immune response|regulation of isotype switching to IgG isotypes|regulation of nucleotide-binding oligomerization domain containing signaling pathway|positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|dipeptide transmembrane transporter activity|L-histidine transmembrane export from vacuole|dipeptide import across plasma membrane|proton transmembrane transport|integral component of lysosomal membrane SLC16A1 3157.652712 3494.493399 2820.812025 0.807216298 -0.308972792 0.331469377 1 39.22512474 33.0270805 6566 solute carrier family 16 member 1 "GO:0005515,GO:0005813,GO:0005886,GO:0005887,GO:0006090,GO:0006629,GO:0007098,GO:0008028,GO:0009925,GO:0015129,GO:0015130,GO:0015293,GO:0015718,GO:0015728,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0030054,GO:0032094,GO:0035879,GO:0042593,GO:0042802,GO:0043231,GO:0045202,GO:0046943,GO:0050796,GO:0050900,GO:0051780,GO:0070062,GO:0071407,GO:0097159,GO:0150104,GO:1905039" protein binding|centrosome|plasma membrane|integral component of plasma membrane|pyruvate metabolic process|lipid metabolic process|centrosome cycle|monocarboxylic acid transmembrane transporter activity|basal plasma membrane|lactate transmembrane transporter activity|mevalonate transmembrane transporter activity|symporter activity|monocarboxylic acid transport|mevalonate transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|cell junction|response to food|plasma membrane lactate transport|glucose homeostasis|identical protein binding|intracellular membrane-bounded organelle|synapse|carboxylic acid transmembrane transporter activity|regulation of insulin secretion|leukocyte migration|behavioral response to nutrient|extracellular exosome|cellular response to organic cyclic compound|organic cyclic compound binding|transport across blood-brain barrier|carboxylic acid transmembrane transport SLC16A10 23.68816172 36.53841486 10.83790858 0.296616824 -1.753327664 0.104064318 1 0.198449524 0.061399067 117247 solute carrier family 16 member 10 "GO:0003333,GO:0005515,GO:0005886,GO:0005887,GO:0006590,GO:0006865,GO:0015171,GO:0015173,GO:0015349,GO:0015801,GO:0016021,GO:0016323,GO:0030054,GO:0043231,GO:0070327,GO:0070460" amino acid transmembrane transport|protein binding|plasma membrane|integral component of plasma membrane|thyroid hormone generation|amino acid transport|amino acid transmembrane transporter activity|aromatic amino acid transmembrane transporter activity|thyroid hormone transmembrane transporter activity|aromatic amino acid transport|integral component of membrane|basolateral plasma membrane|cell junction|intracellular membrane-bounded organelle|thyroid hormone transport|thyroid-stimulating hormone secretion "hsa04919,hsa04974" Thyroid hormone signaling pathway|Protein digestion and absorption SLC16A12 3.552345889 7.104691779 0 0 #NAME? 0.089820349 1 0.045750486 0 387700 solute carrier family 16 member 12 "GO:0005308,GO:0005515,GO:0005886,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0015881,GO:0016021,GO:0016323,GO:0150104" creatine transmembrane transporter activity|protein binding|plasma membrane|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|creatine transmembrane transport|integral component of membrane|basolateral plasma membrane|transport across blood-brain barrier SLC16A13 280.7340486 264.9035077 296.5645894 1.119519299 0.162879399 0.7409941 1 7.437044426 8.684561406 201232 solute carrier family 16 member 13 "GO:0000139,GO:0005515,GO:0005794,GO:0005829,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016021,GO:0055085" Golgi membrane|protein binding|Golgi apparatus|cytosol|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|integral component of membrane|transmembrane transport SLC16A14 35.98912115 35.52345889 36.45478341 1.026217169 0.037336067 1 1 0.345921529 0.370282168 151473 solute carrier family 16 member 14 "GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016021,GO:0055085" integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|integral component of membrane|transmembrane transport SLC16A2 680.8914485 745.9926368 615.7902603 0.825464261 -0.276722341 0.46726547 1 9.152590927 7.880581351 6567 solute carrier family 16 member 2 "GO:0005215,GO:0005886,GO:0005887,GO:0006520,GO:0008028,GO:0015171,GO:0015293,GO:0015349,GO:0015718,GO:0016021,GO:0016324,GO:0042403,GO:0043252,GO:0070327,GO:0089718,GO:0150104,GO:2000178" transporter activity|plasma membrane|integral component of plasma membrane|cellular amino acid metabolic process|monocarboxylic acid transmembrane transporter activity|amino acid transmembrane transporter activity|symporter activity|thyroid hormone transmembrane transporter activity|monocarboxylic acid transport|integral component of membrane|apical plasma membrane|thyroid hormone metabolic process|sodium-independent organic anion transport|thyroid hormone transport|amino acid import across plasma membrane|transport across blood-brain barrier|negative regulation of neural precursor cell proliferation hsa04919 Thyroid hormone signaling pathway SLC16A3 7500.922206 9740.532428 5261.311984 0.540146242 -0.888578033 0.007325001 0.349588273 152.8737543 86.13114478 9123 solute carrier family 16 member 3 "GO:0003723,GO:0005515,GO:0005886,GO:0005887,GO:0006090,GO:0008028,GO:0015129,GO:0015293,GO:0015718,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0031965,GO:0035879,GO:0050900,GO:0098688,GO:0099061" RNA binding|protein binding|plasma membrane|integral component of plasma membrane|pyruvate metabolic process|monocarboxylic acid transmembrane transporter activity|lactate transmembrane transporter activity|symporter activity|monocarboxylic acid transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|nuclear membrane|plasma membrane lactate transport|leukocyte migration|parallel fiber to Purkinje cell synapse|integral component of postsynaptic density membrane hsa05230 Central carbon metabolism in cancer SLC16A4 7.47855778 6.08973581 8.867379749 1.456118956 0.542128219 0.797747104 1 0.114315654 0.173627492 9122 solute carrier family 16 member 4 "GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016020,GO:0016021,GO:0055085" integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|membrane|integral component of membrane|transmembrane transport SLC16A5 497.1762535 479.0592171 515.2932899 1.075635895 0.105189806 0.801022927 1 10.31575652 11.57396859 9121 solute carrier family 16 member 5 "GO:0005515,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016020,GO:0016021,GO:0055085" protein binding|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|membrane|integral component of membrane|transmembrane transport SLC16A6 776.9341941 1182.423703 371.444685 0.314138396 -1.670527808 1.04E-05 0.002647417 13.51514088 4.428508964 9120 solute carrier family 16 member 6 "GO:0005515,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016020,GO:0016021,GO:0055085" protein binding|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|membrane|integral component of membrane|transmembrane transport SLC16A7 449.1061379 493.2686006 404.9436752 0.820939494 -0.284652201 0.499448149 1 1.716054024 1.4694609 9194 solute carrier family 16 member 7 "GO:0005477,GO:0005515,GO:0005654,GO:0005886,GO:0005887,GO:0008028,GO:0015129,GO:0015293,GO:0015718,GO:0016021,GO:0035873,GO:0050833,GO:0150104,GO:1901475" pyruvate secondary active transmembrane transporter activity|protein binding|nucleoplasm|plasma membrane|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|lactate transmembrane transporter activity|symporter activity|monocarboxylic acid transport|integral component of membrane|lactate transmembrane transport|pyruvate transmembrane transporter activity|transport across blood-brain barrier|pyruvate transmembrane transport SLC16A9 4.044978098 7.104691779 0.985264417 0.138677996 -2.850189203 0.227217187 1 0.082472513 0.011929788 220963 solute carrier family 16 member 9 "GO:0005515,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016021,GO:0046415,GO:0055085" protein binding|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|integral component of membrane|urate metabolic process|transmembrane transport SLC17A5 556.4202872 555.1809147 557.6596598 1.004464752 0.006426939 0.992257383 1 8.243317141 8.636795561 26503 solute carrier family 17 member 5 "GO:0005351,GO:0005764,GO:0005765,GO:0005829,GO:0005886,GO:0005887,GO:0006811,GO:0006820,GO:0006865,GO:0009617,GO:0015136,GO:0015538,GO:0015739,GO:0016020,GO:0016021,GO:0022857,GO:0030672,GO:0034219,GO:1902600" carbohydrate:proton symporter activity|lysosome|lysosomal membrane|cytosol|plasma membrane|integral component of plasma membrane|ion transport|anion transport|amino acid transport|response to bacterium|sialic acid transmembrane transporter activity|sialic acid:proton symporter activity|sialic acid transport|membrane|integral component of membrane|transmembrane transporter activity|synaptic vesicle membrane|carbohydrate transmembrane transport|proton transmembrane transport hsa04142 Lysosome SLC17A7 11.98647653 11.16451565 12.80843742 1.147245238 0.198173818 0.947374756 1 0.191740703 0.229449179 57030 solute carrier family 17 member 7 "GO:0003407,GO:0005313,GO:0005326,GO:0005436,GO:0005886,GO:0006811,GO:0006817,GO:0006820,GO:0007420,GO:0014047,GO:0015319,GO:0015813,GO:0016021,GO:0022857,GO:0030285,GO:0030672,GO:0035249,GO:0035725,GO:0043005,GO:0043229,GO:0048786,GO:0050803,GO:0060076,GO:0060203,GO:0098700,GO:1900242" "neural retina development|L-glutamate transmembrane transporter activity|neurotransmitter transmembrane transporter activity|sodium:phosphate symporter activity|plasma membrane|ion transport|phosphate ion transport|anion transport|brain development|glutamate secretion|sodium:inorganic phosphate symporter activity|L-glutamate transmembrane transport|integral component of membrane|transmembrane transporter activity|integral component of synaptic vesicle membrane|synaptic vesicle membrane|synaptic transmission, glutamatergic|sodium ion transmembrane transport|neuron projection|intracellular organelle|presynaptic active zone|regulation of synapse structure or activity|excitatory synapse|clathrin-sculpted glutamate transport vesicle membrane|neurotransmitter loading into synaptic vesicle|regulation of synaptic vesicle endocytosis" "hsa04721,hsa04723,hsa04724,hsa05033" Synaptic vesicle cycle|Retrograde endocannabinoid signaling|Glutamatergic synapse|Nicotine addiction SLC17A9 675.1877029 760.2020203 590.1733855 0.776337565 -0.365243997 0.337622323 1 15.00450136 12.15033069 63910 solute carrier family 17 member 9 "GO:0001409,GO:0005347,GO:0005515,GO:0006887,GO:0015217,GO:0015866,GO:0015867,GO:0016021,GO:0042584,GO:1903790,GO:1904669" guanine nucleotide transmembrane transporter activity|ATP transmembrane transporter activity|protein binding|exocytosis|ADP transmembrane transporter activity|ADP transport|ATP transport|integral component of membrane|chromaffin granule membrane|guanine nucleotide transmembrane transport|ATP export SLC18B1 226.2745601 280.1278473 172.4212729 0.61550922 -0.700147626 0.176745741 1 5.217906301 3.350015134 116843 solute carrier family 18 member B1 "GO:0016021,GO:0022857,GO:0055085" integral component of membrane|transmembrane transporter activity|transmembrane transport SLC19A1 624.4992876 662.7662473 586.2323278 0.884523511 -0.177027605 0.649758359 1 4.116097159 3.797614949 6573 solute carrier family 19 member 1 "GO:0005542,GO:0005886,GO:0005887,GO:0007565,GO:0008514,GO:0008517,GO:0008518,GO:0015350,GO:0015711,GO:0015884,GO:0016323,GO:0016324,GO:0031526,GO:0046655,GO:0051958,GO:0055085,GO:0061507,GO:0098838,GO:0140360,GO:0140361,GO:0150104,GO:1904447" folic acid binding|plasma membrane|integral component of plasma membrane|female pregnancy|organic anion transmembrane transporter activity|folic acid transmembrane transporter activity|folate:anion antiporter activity|methotrexate transmembrane transporter activity|organic anion transport|folic acid transport|basolateral plasma membrane|apical plasma membrane|brush border membrane|folic acid metabolic process|methotrexate transport|transmembrane transport|cyclic-GMP-AMP binding|folate transmembrane transport|cyclic-GMP-AMP transmembrane transporter activity|cyclic-GMP-AMP transmembrane import across plasma membrane|transport across blood-brain barrier|folate import across plasma membrane "hsa01523,hsa04977" Antifolate resistance|Vitamin digestion and absorption SLC19A2 261.2366011 279.1128913 243.3603109 0.871906381 -0.197754858 0.693697274 1 3.913644323 3.559320857 10560 solute carrier family 19 member 2 "GO:0005515,GO:0005886,GO:0008517,GO:0015234,GO:0015884,GO:0015888,GO:0016021,GO:0042723,GO:0055085,GO:0071934" protein binding|plasma membrane|folic acid transmembrane transporter activity|thiamine transmembrane transporter activity|folic acid transport|thiamine transport|integral component of membrane|thiamine-containing compound metabolic process|transmembrane transport|thiamine transmembrane transport hsa04977 Vitamin digestion and absorption SLC1A1 89.3364142 112.6601125 66.01271591 0.585945766 -0.771160957 0.274271633 1 1.187232055 0.725619531 6505 solute carrier family 1 member 1 "GO:0001662,GO:0001932,GO:0005313,GO:0005314,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0006749,GO:0006811,GO:0006882,GO:0006919,GO:0007268,GO:0007611,GO:0009986,GO:0010460,GO:0010842,GO:0014047,GO:0015108,GO:0015183,GO:0015501,GO:0015813,GO:0016020,GO:0016021,GO:0016324,GO:0016595,GO:0018105,GO:0030424,GO:0030425,GO:0031901,GO:0031902,GO:0032279,GO:0033229,GO:0035633,GO:0036293,GO:0036475,GO:0042802,GO:0042883,GO:0043025,GO:0043083,GO:0043197,GO:0043198,GO:0043204,GO:0043679,GO:0046872,GO:0048514,GO:0048678,GO:0051938,GO:0055038,GO:0060013,GO:0060047,GO:0060291,GO:0070062,GO:0070633,GO:0070777,GO:0070778,GO:0070779,GO:0071242,GO:0071944,GO:0072347,GO:0090313,GO:0090461,GO:0097049,GO:0097386,GO:0097440,GO:0098712,GO:0098793,GO:0098877,GO:0099544,GO:0140009,GO:0140010,GO:0150002,GO:0150104,GO:1902476,GO:1903712,GO:1990635" behavioral fear response|regulation of protein phosphorylation|L-glutamate transmembrane transporter activity|high-affinity glutamate transmembrane transporter activity|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|glutathione metabolic process|ion transport|cellular zinc ion homeostasis|activation of cysteine-type endopeptidase activity involved in apoptotic process|chemical synaptic transmission|learning or memory|cell surface|positive regulation of heart rate|retina layer formation|glutamate secretion|chloride transmembrane transporter activity|L-aspartate transmembrane transporter activity|glutamate:sodium symporter activity|L-glutamate transmembrane transport|membrane|integral component of membrane|apical plasma membrane|glutamate binding|peptidyl-serine phosphorylation|axon|dendrite|early endosome membrane|late endosome membrane|asymmetric synapse|cysteine transmembrane transporter activity|maintenance of blood-brain barrier|response to decreased oxygen levels|neuron death in response to oxidative stress|identical protein binding|cysteine transport|neuronal cell body|synaptic cleft|dendritic spine|dendritic shaft|perikaryon|axon terminus|metal ion binding|blood vessel morphogenesis|response to axon injury|L-glutamate import|recycling endosome membrane|righting reflex|heart contraction|long-term synaptic potentiation|extracellular exosome|transepithelial transport|D-aspartate transport|L-aspartate transmembrane transport|D-aspartate import across plasma membrane|cellular response to ammonium ion|cell periphery|response to anesthetic|regulation of protein targeting to membrane|glutamate homeostasis|motor neuron apoptotic process|glial cell projection|apical dendrite|L-glutamate import across plasma membrane|presynapse|neurotransmitter receptor transport to plasma membrane|perisynaptic space|L-aspartate import across plasma membrane|D-aspartate transmembrane transporter activity|distal dendrite|transport across blood-brain barrier|chloride transmembrane transport|cysteine transmembrane transport|proximal dendrite "hsa04721,hsa04724,hsa04974" Synaptic vesicle cycle|Glutamatergic synapse|Protein digestion and absorption SLC1A3 217.1251106 260.8436839 173.4065373 0.664791015 -0.589027212 0.262192889 1 3.538926436 2.453988967 6507 solute carrier family 1 member 3 "GO:0001504,GO:0005313,GO:0005314,GO:0005515,GO:0005886,GO:0005887,GO:0006811,GO:0007268,GO:0009925,GO:0014047,GO:0015501,GO:0015813,GO:0016020,GO:0031410,GO:0043005,GO:0043025,GO:0045202,GO:0046872,GO:0048471,GO:0051938,GO:0070633,GO:0070779,GO:0071805,GO:0098712,GO:0098796,GO:0140009,GO:0150104,GO:1902476" neurotransmitter uptake|L-glutamate transmembrane transporter activity|high-affinity glutamate transmembrane transporter activity|protein binding|plasma membrane|integral component of plasma membrane|ion transport|chemical synaptic transmission|basal plasma membrane|glutamate secretion|glutamate:sodium symporter activity|L-glutamate transmembrane transport|membrane|cytoplasmic vesicle|neuron projection|neuronal cell body|synapse|metal ion binding|perinuclear region of cytoplasm|L-glutamate import|transepithelial transport|D-aspartate import across plasma membrane|potassium ion transmembrane transport|L-glutamate import across plasma membrane|membrane protein complex|L-aspartate import across plasma membrane|transport across blood-brain barrier|chloride transmembrane transport "hsa04721,hsa04724,hsa05016" Synaptic vesicle cycle|Glutamatergic synapse|Huntington disease SLC1A4 522.4355919 286.2175831 758.6536007 2.65061843 1.406329002 0.000619116 0.0676734 3.124792168 8.639413894 6509 solute carrier family 1 member 4 "GO:0005254,GO:0005813,GO:0005882,GO:0005886,GO:0005887,GO:0006865,GO:0006868,GO:0009986,GO:0015171,GO:0015180,GO:0015183,GO:0015184,GO:0015186,GO:0015193,GO:0015194,GO:0015195,GO:0015293,GO:0015808,GO:0015811,GO:0015824,GO:0015825,GO:0015826,GO:0016020,GO:0016021,GO:0030425,GO:0034589,GO:0034590,GO:0035249,GO:0035524,GO:0042470,GO:0043025,GO:0045202,GO:0050890,GO:0070062,GO:0140009,GO:0150104,GO:1902476,GO:1903812,GO:1904273" "chloride channel activity|centrosome|intermediate filament|plasma membrane|integral component of plasma membrane|amino acid transport|glutamine transport|cell surface|amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-aspartate transmembrane transporter activity|L-cystine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|symporter activity|L-alanine transport|L-cystine transport|proline transport|L-serine transport|threonine transport|membrane|integral component of membrane|dendrite|hydroxyproline transport|L-hydroxyproline transmembrane transporter activity|synaptic transmission, glutamatergic|proline transmembrane transport|melanosome|neuronal cell body|synapse|cognition|extracellular exosome|L-aspartate import across plasma membrane|transport across blood-brain barrier|chloride transmembrane transport|L-serine import across plasma membrane|L-alanine import across plasma membrane" SLC1A5 1811.018934 1488.940406 2133.097462 1.43262783 0.518663873 0.110741346 1 23.88646781 35.69449538 6510 solute carrier family 1 member 5 "GO:0001618,GO:0005515,GO:0005886,GO:0005887,GO:0006865,GO:0006868,GO:0009925,GO:0010585,GO:0015171,GO:0015175,GO:0015183,GO:0015186,GO:0015194,GO:0015293,GO:0015804,GO:0015825,GO:0016020,GO:0016021,GO:0038023,GO:0042470,GO:0046718,GO:0046872,GO:0070062,GO:0070207,GO:0140009,GO:0150104,GO:1903803" virus receptor activity|protein binding|plasma membrane|integral component of plasma membrane|amino acid transport|glutamine transport|basal plasma membrane|glutamine secretion|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-aspartate transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-serine transmembrane transporter activity|symporter activity|neutral amino acid transport|L-serine transport|membrane|integral component of membrane|signaling receptor activity|melanosome|viral entry into host cell|metal ion binding|extracellular exosome|protein homotrimerization|L-aspartate import across plasma membrane|transport across blood-brain barrier|L-glutamine import across plasma membrane "hsa04974,hsa05230" Protein digestion and absorption|Central carbon metabolism in cancer SLC20A1 1937.117687 1858.384378 2015.850996 1.084733072 0.117340073 0.717314706 1 27.7396442 31.38626936 6574 solute carrier family 20 member 1 "GO:0005315,GO:0005316,GO:0005436,GO:0005886,GO:0005887,GO:0006796,GO:0006811,GO:0016020,GO:0016032,GO:0031214,GO:0035435,GO:0035725,GO:0038023,GO:0043123" inorganic phosphate transmembrane transporter activity|high-affinity inorganic phosphate:sodium symporter activity|sodium:phosphate symporter activity|plasma membrane|integral component of plasma membrane|phosphate-containing compound metabolic process|ion transport|membrane|viral process|biomineral tissue development|phosphate ion transmembrane transport|sodium ion transmembrane transport|signaling receptor activity|positive regulation of I-kappaB kinase/NF-kappaB signaling SLC20A2 407.2054303 457.7451417 356.6657188 0.779179693 -0.359972017 0.404995853 1 2.888869358 2.347910064 6575 solute carrier family 20 member 2 "GO:0001618,GO:0005315,GO:0005436,GO:0005886,GO:0005887,GO:0006811,GO:0016020,GO:0035435,GO:0035725,GO:0038023,GO:0046718,GO:0070062" virus receptor activity|inorganic phosphate transmembrane transporter activity|sodium:phosphate symporter activity|plasma membrane|integral component of plasma membrane|ion transport|membrane|phosphate ion transmembrane transport|sodium ion transmembrane transport|signaling receptor activity|viral entry into host cell|extracellular exosome SLC22A1 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.03407243 0 6580 solute carrier family 22 member 1 "GO:0005277,GO:0005326,GO:0005330,GO:0005334,GO:0005515,GO:0005886,GO:0005887,GO:0006836,GO:0006855,GO:0008504,GO:0008513,GO:0010248,GO:0015101,GO:0015214,GO:0015651,GO:0015695,GO:0015697,GO:0015874,GO:0016020,GO:0016323,GO:0016324,GO:0019534,GO:0042802,GO:0042908,GO:0042910,GO:0048241,GO:0051610,GO:0051620,GO:0072531,GO:0090494,GO:0098655,GO:0098793,GO:0150104,GO:1901374,GO:1901998,GO:1990962" acetylcholine transmembrane transporter activity|neurotransmitter transmembrane transporter activity|dopamine:sodium symporter activity|norepinephrine:sodium symporter activity|protein binding|plasma membrane|integral component of plasma membrane|neurotransmitter transport|drug transmembrane transport|monoamine transmembrane transporter activity|secondary active organic cation transmembrane transporter activity|establishment or maintenance of transmembrane electrochemical gradient|organic cation transmembrane transporter activity|pyrimidine nucleoside transmembrane transporter activity|quaternary ammonium group transmembrane transporter activity|organic cation transport|quaternary ammonium group transport|norepinephrine transport|membrane|basolateral plasma membrane|apical plasma membrane|toxin transmembrane transporter activity|identical protein binding|xenobiotic transport|xenobiotic transmembrane transporter activity|epinephrine transport|serotonin uptake|norepinephrine uptake|pyrimidine-containing compound transmembrane transport|dopamine uptake|cation transmembrane transport|presynapse|transport across blood-brain barrier|acetate ester transport|toxin transport|xenobiotic transport across blood-brain barrier "hsa04976,hsa05231" Bile secretion|Choline metabolism in cancer SLC22A13 12.04585964 15.22433953 8.867379749 0.582447582 -0.779799875 0.579059576 1 0.257276973 0.156305296 9390 solute carrier family 22 member 13 "GO:0002854,GO:0005783,GO:0005794,GO:0005886,GO:0015747,GO:0016021,GO:0016324,GO:0034356,GO:0045922,GO:0055085,GO:0070062,GO:0090416,GO:2001142" positive regulation of T cell mediated cytotoxicity directed against tumor cell target|endoplasmic reticulum|Golgi apparatus|plasma membrane|urate transport|integral component of membrane|apical plasma membrane|NAD biosynthesis via nicotinamide riboside salvage pathway|negative regulation of fatty acid metabolic process|transmembrane transport|extracellular exosome|nicotinate transmembrane transporter activity|nicotinate transport SLC22A14 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.068675938 0.069538629 9389 solute carrier family 22 member 14 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021,GO:0022857,GO:0055085" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC22A15 580.0626739 420.1917709 739.9335768 1.76094257 0.816347859 0.038950888 0.905558037 2.631861347 4.834194589 55356 solute carrier family 22 member 15 "GO:0003674,GO:0005575,GO:0006811,GO:0008150,GO:0016021,GO:0022857,GO:0055085" molecular_function|cellular_component|ion transport|biological_process|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC22A17 96.92433562 58.86744617 134.9812251 2.29296893 1.197216807 0.082560671 1 1.221896917 2.922460626 51310 solute carrier family 22 member 17 "GO:0004888,GO:0005515,GO:0005774,GO:0005886,GO:0005887,GO:0006879,GO:0015891,GO:0022857,GO:0031301,GO:0055085" transmembrane signaling receptor activity|protein binding|vacuolar membrane|plasma membrane|integral component of plasma membrane|cellular iron ion homeostasis|siderophore transport|transmembrane transporter activity|integral component of organelle membrane|transmembrane transport SLC22A18 279.6812362 361.3243247 198.0381477 0.548089719 -0.867516021 0.073552385 1 7.847256592 4.486270328 5002 solute carrier family 22 member 18 "GO:0005515,GO:0005635,GO:0005737,GO:0005886,GO:0007588,GO:0015293,GO:0015695,GO:0016020,GO:0016021,GO:0016324,GO:0022857,GO:0031625,GO:0042908,GO:1990961" protein binding|nuclear envelope|cytoplasm|plasma membrane|excretion|symporter activity|organic cation transport|membrane|integral component of membrane|apical plasma membrane|transmembrane transporter activity|ubiquitin protein ligase binding|xenobiotic transport|xenobiotic detoxification by transmembrane export across the plasma membrane SLC22A23 703.7225146 858.6527492 548.79228 0.639131803 -0.645814617 0.087341278 1 4.300181213 2.866771748 63027 solute carrier family 22 member 23 "GO:0005515,GO:0006811,GO:0016021,GO:0022857,GO:0055085" protein binding|ion transport|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC22A3 7.537940883 10.14955968 4.926322083 0.485372985 -1.042834281 0.538494358 1 0.035225066 0.017833778 6581 solute carrier family 22 member 3 "GO:0001692,GO:0005326,GO:0005330,GO:0005515,GO:0005886,GO:0005887,GO:0006836,GO:0006855,GO:0008504,GO:0008514,GO:0015101,GO:0015651,GO:0015695,GO:0015697,GO:0015711,GO:0015718,GO:0015844,GO:0016020,GO:0019534,GO:0032098,GO:0042908,GO:0043025,GO:0051610,GO:0051615,GO:0051620,GO:0051625,GO:0090494,GO:0098793,GO:0150104,GO:1901998" histamine metabolic process|neurotransmitter transmembrane transporter activity|dopamine:sodium symporter activity|protein binding|plasma membrane|integral component of plasma membrane|neurotransmitter transport|drug transmembrane transport|monoamine transmembrane transporter activity|organic anion transmembrane transporter activity|organic cation transmembrane transporter activity|quaternary ammonium group transmembrane transporter activity|organic cation transport|quaternary ammonium group transport|organic anion transport|monocarboxylic acid transport|monoamine transport|membrane|toxin transmembrane transporter activity|regulation of appetite|xenobiotic transport|neuronal cell body|serotonin uptake|histamine uptake|norepinephrine uptake|epinephrine uptake|dopamine uptake|presynapse|transport across blood-brain barrier|toxin transport hsa05231 Choline metabolism in cancer SLC22A4 389.7042438 338.9952934 440.4131942 1.299172002 0.377592447 0.388319111 1 6.005217107 8.137880265 6583 solute carrier family 22 member 4 "GO:0000166,GO:0005515,GO:0005524,GO:0005739,GO:0005886,GO:0005887,GO:0006641,GO:0006814,GO:0007589,GO:0008513,GO:0009437,GO:0015171,GO:0015226,GO:0015293,GO:0015491,GO:0015651,GO:0015695,GO:0015697,GO:0015879,GO:0016324,GO:0030165,GO:0042908,GO:0089718,GO:1902603" nucleotide binding|protein binding|ATP binding|mitochondrion|plasma membrane|integral component of plasma membrane|triglyceride metabolic process|sodium ion transport|body fluid secretion|secondary active organic cation transmembrane transporter activity|carnitine metabolic process|amino acid transmembrane transporter activity|carnitine transmembrane transporter activity|symporter activity|cation:cation antiporter activity|quaternary ammonium group transmembrane transporter activity|organic cation transport|quaternary ammonium group transport|carnitine transport|apical plasma membrane|PDZ domain binding|xenobiotic transport|amino acid import across plasma membrane|carnitine transmembrane transport hsa05231 Choline metabolism in cancer SLC22A5 279.9269335 277.0829794 282.7708875 1.020527815 0.029315505 0.959646086 1 4.187787351 4.457849443 6584 solute carrier family 22 member 5 "GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006814,GO:0009609,GO:0015226,GO:0015293,GO:0015651,GO:0015697,GO:0015879,GO:0016021,GO:0016324,GO:0030165,GO:0031526,GO:0042910,GO:0060731,GO:0070062,GO:0070715,GO:0150104,GO:1901235,GO:1902270,GO:1902603,GO:1990961" protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|sodium ion transport|response to symbiotic bacterium|carnitine transmembrane transporter activity|symporter activity|quaternary ammonium group transmembrane transporter activity|quaternary ammonium group transport|carnitine transport|integral component of membrane|apical plasma membrane|PDZ domain binding|brush border membrane|xenobiotic transmembrane transporter activity|positive regulation of intestinal epithelial structure maintenance|extracellular exosome|sodium-dependent organic cation transport|transport across blood-brain barrier|(R)-carnitine transmembrane transporter activity|(R)-carnitine transmembrane transport|carnitine transmembrane transport|xenobiotic detoxification by transmembrane export across the plasma membrane hsa05231 Choline metabolism in cancer SLC23A2 2633.17533 2799.248561 2467.102099 0.88134442 -0.182222176 0.567807406 1 20.01017141 18.39553393 9962 solute carrier family 23 member 2 "GO:0005215,GO:0005737,GO:0005886,GO:0005887,GO:0006814,GO:0006979,GO:0008520,GO:0009925,GO:0015229,GO:0015882,GO:0016021,GO:0016323,GO:0016324,GO:0019852,GO:0070904,GO:0071361,GO:1901215,GO:1903861" transporter activity|cytoplasm|plasma membrane|integral component of plasma membrane|sodium ion transport|response to oxidative stress|L-ascorbate:sodium symporter activity|basal plasma membrane|L-ascorbic acid transmembrane transporter activity|L-ascorbic acid transmembrane transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|L-ascorbic acid metabolic process|transepithelial L-ascorbic acid transport|cellular response to ethanol|negative regulation of neuron death|positive regulation of dendrite extension SLC23A3 12.03101386 14.20938356 9.852644165 0.693389979 -0.528261108 0.729410839 1 0.306758376 0.221865574 151295 solute carrier family 23 member 3 "GO:0005215,GO:0016021,GO:0022857,GO:0055085" transporter activity|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC24A1 294.2996205 316.6662621 271.932979 0.85873682 -0.219712043 0.647902268 1 1.495108515 1.339210141 9187 solute carrier family 24 member 1 "GO:0005262,GO:0005515,GO:0005886,GO:0005887,GO:0006811,GO:0006816,GO:0006874,GO:0007601,GO:0008273,GO:0009642,GO:0015293,GO:0016020,GO:0019867,GO:0035725,GO:0043025,GO:0044214,GO:0060291,GO:0060292,GO:0070588,GO:0071805,GO:0098656,GO:0098703" "calcium channel activity|protein binding|plasma membrane|integral component of plasma membrane|ion transport|calcium ion transport|cellular calcium ion homeostasis|visual perception|calcium, potassium:sodium antiporter activity|response to light intensity|symporter activity|membrane|outer membrane|sodium ion transmembrane transport|neuronal cell body|spanning component of plasma membrane|long-term synaptic potentiation|long-term synaptic depression|calcium ion transmembrane transport|potassium ion transmembrane transport|anion transmembrane transport|calcium ion import across plasma membrane" hsa04744 Phototransduction SLC25A1 2570.889396 2313.084652 2828.69414 1.222909908 0.290318125 0.362692459 1 64.61642446 82.42392968 6576 solute carrier family 25 member 1 "GO:0005634,GO:0005743,GO:0006094,GO:0006843,GO:0015137,GO:0015142,GO:0016021,GO:0046949,GO:0070062,GO:0071913" nucleus|mitochondrial inner membrane|gluconeogenesis|mitochondrial citrate transmembrane transport|citrate transmembrane transporter activity|tricarboxylic acid transmembrane transporter activity|integral component of membrane|fatty-acyl-CoA biosynthetic process|extracellular exosome|citrate secondary active transmembrane transporter activity SLC25A10 469.2095406 554.1659587 384.2531225 0.693389979 -0.528261108 0.203544471 1 12.67685223 9.168639948 1468 solute carrier family 25 member 10 "GO:0005310,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0006094,GO:0006811,GO:0006835,GO:0006839,GO:0008272,GO:0015116,GO:0015117,GO:0015131,GO:0015140,GO:0015141,GO:0015297,GO:0015709,GO:0015729,GO:0016021,GO:0035435,GO:0070221,GO:0071422,GO:0071423,GO:1902356,GO:1902358" "dicarboxylic acid transmembrane transporter activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|gluconeogenesis|ion transport|dicarboxylic acid transport|mitochondrial transport|sulfate transport|sulfate transmembrane transporter activity|thiosulfate transmembrane transporter activity|oxaloacetate transmembrane transporter activity|malate transmembrane transporter activity|succinate transmembrane transporter activity|antiporter activity|thiosulfate transport|oxaloacetate transport|integral component of membrane|phosphate ion transmembrane transport|sulfide oxidation, using sulfide:quinone oxidoreductase|succinate transmembrane transport|malate transmembrane transport|oxaloacetate(2-) transmembrane transport|sulfate transmembrane transport" hsa04964 Proximal tubule bicarbonate reclamation SLC25A11 1331.479954 1474.731022 1188.228886 0.805725837 -0.311639077 0.355024303 1 37.70314171 31.68697346 8402 solute carrier family 25 member 11 "GO:0003723,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005887,GO:0006094,GO:0008272,GO:0015116,GO:0015117,GO:0015131,GO:0015140,GO:0015141,GO:0015297,GO:0015367,GO:0015709,GO:0015729,GO:0015742,GO:0035435,GO:0071422,GO:0071423,GO:1902356,GO:1902358" RNA binding|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|gluconeogenesis|sulfate transport|sulfate transmembrane transporter activity|thiosulfate transmembrane transporter activity|oxaloacetate transmembrane transporter activity|malate transmembrane transporter activity|succinate transmembrane transporter activity|antiporter activity|oxoglutarate:malate antiporter activity|thiosulfate transport|oxaloacetate transport|alpha-ketoglutarate transport|phosphate ion transmembrane transport|succinate transmembrane transport|malate transmembrane transport|oxaloacetate(2-) transmembrane transport|sulfate transmembrane transport SLC25A12 668.2099421 653.6316436 682.7882407 1.044607077 0.062960383 0.87254163 1 8.194093286 8.928321027 8604 solute carrier family 25 member 12 "GO:0005313,GO:0005509,GO:0005739,GO:0005743,GO:0006094,GO:0006537,GO:0006810,GO:0010907,GO:0015183,GO:0015810,GO:0015813,GO:0016021,GO:0022857,GO:0031643,GO:0042802,GO:0043490,GO:0051592,GO:0070778,GO:1904024,GO:2001171" L-glutamate transmembrane transporter activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|gluconeogenesis|glutamate biosynthetic process|transport|positive regulation of glucose metabolic process|L-aspartate transmembrane transporter activity|aspartate transmembrane transport|L-glutamate transmembrane transport|integral component of membrane|transmembrane transporter activity|positive regulation of myelination|identical protein binding|malate-aspartate shuttle|response to calcium ion|L-aspartate transmembrane transport|negative regulation of glucose catabolic process to lactate via pyruvate|positive regulation of ATP biosynthetic process SLC25A13 965.9889175 1140.810508 791.1673265 0.693513358 -0.528004424 0.136655257 1 16.51272584 11.94509287 10165 solute carrier family 25 member 13 "GO:0005313,GO:0005509,GO:0005739,GO:0005743,GO:0005887,GO:0006094,GO:0006754,GO:0006810,GO:0006839,GO:0015183,GO:0015810,GO:0015813,GO:0022857,GO:0042802,GO:0043490,GO:0045333,GO:0051592,GO:0070778" L-glutamate transmembrane transporter activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|gluconeogenesis|ATP biosynthetic process|transport|mitochondrial transport|L-aspartate transmembrane transporter activity|aspartate transmembrane transport|L-glutamate transmembrane transport|transmembrane transporter activity|identical protein binding|malate-aspartate shuttle|cellular respiration|response to calcium ion|L-aspartate transmembrane transport SLC25A14 285.704908 267.9483757 303.4614403 1.132536966 0.17955814 0.713138889 1 3.331853661 3.935992247 9016 solute carrier family 25 member 14 "GO:0005739,GO:0005743,GO:0005887,GO:0006839,GO:0008272,GO:0009060,GO:0015116,GO:0015117,GO:0015131,GO:0015140,GO:0015141,GO:0015297,GO:0015709,GO:0015729,GO:0035435,GO:0071422,GO:0071423,GO:1902356,GO:1902358,GO:1902600" mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|mitochondrial transport|sulfate transport|aerobic respiration|sulfate transmembrane transporter activity|thiosulfate transmembrane transporter activity|oxaloacetate transmembrane transporter activity|malate transmembrane transporter activity|succinate transmembrane transporter activity|antiporter activity|thiosulfate transport|oxaloacetate transport|phosphate ion transmembrane transport|succinate transmembrane transport|malate transmembrane transport|oxaloacetate(2-) transmembrane transport|sulfate transmembrane transport|proton transmembrane transport SLC25A15 347.0773309 422.2216828 271.932979 0.644052615 -0.634749543 0.160589245 1 5.596450858 3.759672123 10166 solute carrier family 25 member 15 "GO:0000050,GO:0000064,GO:0005743,GO:0016021,GO:1990575" urea cycle|L-ornithine transmembrane transporter activity|mitochondrial inner membrane|integral component of membrane|mitochondrial L-ornithine transmembrane transport SLC25A16 413.9444209 379.5935322 448.2953095 1.180987745 0.239993994 0.578579801 1 2.460336995 3.030790503 8034 solute carrier family 25 member 16 "GO:0005739,GO:0005743,GO:0006839,GO:0015291,GO:0015297,GO:0016021,GO:0055085" mitochondrion|mitochondrial inner membrane|mitochondrial transport|secondary active transmembrane transporter activity|antiporter activity|integral component of membrane|transmembrane transport SLC25A17 637.921845 637.3923481 638.4513419 1.001661447 0.002394973 0.999724902 1 14.16484153 14.79955335 10478 solute carrier family 25 member 17 "GO:0000295,GO:0001561,GO:0005347,GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0006635,GO:0015217,GO:0015228,GO:0015230,GO:0015866,GO:0015867,GO:0015908,GO:0016020,GO:0035349,GO:0035350,GO:0035352,GO:0044610,GO:0051087,GO:0051724,GO:0080121,GO:0080122" adenine nucleotide transmembrane transporter activity|fatty acid alpha-oxidation|ATP transmembrane transporter activity|protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|fatty acid beta-oxidation|ADP transmembrane transporter activity|coenzyme A transmembrane transporter activity|FAD transmembrane transporter activity|ADP transport|ATP transport|fatty acid transport|membrane|coenzyme A transmembrane transport|FAD transmembrane transport|NAD transmembrane transport|FMN transmembrane transporter activity|chaperone binding|NAD transmembrane transporter activity|AMP transport|AMP transmembrane transporter activity hsa04146 Peroxisome SLC25A19 217.9201015 214.1557093 221.6844937 1.035155656 0.049847721 0.933319812 1 3.699260294 3.994261369 60386 solute carrier family 25 member 19 "GO:0005634,GO:0005743,GO:0015234,GO:0030233,GO:0030302,GO:0030974,GO:0031305,GO:0042723,GO:0071934,GO:0090422" nucleus|mitochondrial inner membrane|thiamine transmembrane transporter activity|deoxynucleotide transmembrane transporter activity|deoxynucleotide transport|thiamine pyrophosphate transmembrane transport|integral component of mitochondrial inner membrane|thiamine-containing compound metabolic process|thiamine transmembrane transport|thiamine pyrophosphate transmembrane transporter activity SLC25A20 342.3197556 366.3991046 318.2404065 0.868562184 -0.203298953 0.657706556 1 10.4369078 9.455591326 788 solute carrier family 25 member 20 "GO:0001701,GO:0005515,GO:0005739,GO:0005743,GO:0005829,GO:0006853,GO:0015227,GO:0016021,GO:1902603,GO:1902616" in utero embryonic development|protein binding|mitochondrion|mitochondrial inner membrane|cytosol|carnitine shuttle|acyl carnitine transmembrane transporter activity|integral component of membrane|carnitine transmembrane transport|acyl carnitine transmembrane transport hsa04714 Thermogenesis SLC25A21 43.15591764 20.29911937 66.01271591 3.251999001 1.701326814 0.059962353 1 0.203217787 0.689331383 89874 solute carrier family 25 member 21 "GO:0005743,GO:0006554,GO:0015139,GO:0016021,GO:1990550" mitochondrial inner membrane|lysine catabolic process|alpha-ketoglutarate transmembrane transporter activity|integral component of membrane|mitochondrial alpha-ketoglutarate transmembrane transport SLC25A22 653.9478565 722.6486495 585.2470634 0.809863914 -0.304248591 0.428077894 1 10.21194329 8.626534666 79751 solute carrier family 25 member 22 "GO:0005313,GO:0005743,GO:0006810,GO:0006811,GO:0015183,GO:0015293,GO:0015810,GO:0015813,GO:0016021,GO:0022857,GO:0043490,GO:0070778" L-glutamate transmembrane transporter activity|mitochondrial inner membrane|transport|ion transport|L-aspartate transmembrane transporter activity|symporter activity|aspartate transmembrane transport|L-glutamate transmembrane transport|integral component of membrane|transmembrane transporter activity|malate-aspartate shuttle|L-aspartate transmembrane transport SLC25A23 890.3356037 919.5501073 861.1211001 0.936459137 -0.094712052 0.794767059 1 11.15496262 10.89614517 79085 solute carrier family 25 member 23 "GO:0002082,GO:0005347,GO:0005509,GO:0005515,GO:0005739,GO:0005743,GO:0006851,GO:0015867,GO:0016021,GO:0036444,GO:0043457,GO:0051282,GO:0051561,GO:0071277,GO:0097274,GO:1900069" regulation of oxidative phosphorylation|ATP transmembrane transporter activity|calcium ion binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|ATP transport|integral component of membrane|calcium import into the mitochondrion|regulation of cellular respiration|regulation of sequestering of calcium ion|positive regulation of mitochondrial calcium ion concentration|cellular response to calcium ion|urea homeostasis|regulation of cellular hyperosmotic salinity response SLC25A24 2341.258207 2005.552994 2676.96342 1.334775709 0.416597337 0.192688228 1 22.13427412 30.8169397 29957 solute carrier family 25 member 24 "GO:0005347,GO:0005509,GO:0005739,GO:0005743,GO:0006839,GO:0010941,GO:0015867,GO:0016021,GO:0034599,GO:0055085,GO:0071277" ATP transmembrane transporter activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial transport|regulation of cell death|ATP transport|integral component of membrane|cellular response to oxidative stress|transmembrane transport|cellular response to calcium ion SLC25A25 368.3659201 227.3501369 509.3817034 2.240516369 1.163831267 0.009420409 0.40793681 2.334174415 5.455032665 114789 solute carrier family 25 member 25 "GO:0002021,GO:0005347,GO:0005509,GO:0005743,GO:0014823,GO:0015867,GO:0016021,GO:0032094,GO:0035264,GO:0043010,GO:0045333,GO:0046034,GO:0060612,GO:0070588" response to dietary excess|ATP transmembrane transporter activity|calcium ion binding|mitochondrial inner membrane|response to activity|ATP transport|integral component of membrane|response to food|multicellular organism growth|camera-type eye development|cellular respiration|ATP metabolic process|adipose tissue development|calcium ion transmembrane transport SLC25A26 264.7174397 247.6492563 281.7856231 1.137841588 0.186299718 0.709868226 1 1.762833616 2.092228225 115286 solute carrier family 25 member 26 "GO:0000095,GO:0005739,GO:0005743,GO:0006811,GO:0015805,GO:0016021,GO:1901962" S-adenosyl-L-methionine transmembrane transporter activity|mitochondrion|mitochondrial inner membrane|ion transport|S-adenosyl-L-methionine transport|integral component of membrane|S-adenosyl-L-methionine transmembrane transport SLC25A27 249.8372746 207.0510175 292.6235317 1.413291928 0.499059498 0.320362157 1 3.547497837 5.229617768 9481 solute carrier family 25 member 27 "GO:0005739,GO:0005743,GO:0008284,GO:0009409,GO:0010917,GO:0016021,GO:0031966,GO:0035356,GO:0043025,GO:0043066,GO:0045177,GO:0046324,GO:0048839,GO:0051562,GO:0070997,GO:1902600" mitochondrion|mitochondrial inner membrane|positive regulation of cell population proliferation|response to cold|negative regulation of mitochondrial membrane potential|integral component of membrane|mitochondrial membrane|cellular triglyceride homeostasis|neuronal cell body|negative regulation of apoptotic process|apical part of cell|regulation of glucose import|inner ear development|negative regulation of mitochondrial calcium ion concentration|neuron death|proton transmembrane transport SLC25A28 1235.068786 979.4325095 1490.705062 1.522008967 0.605976859 0.075638511 1 9.49374189 15.07198874 81894 solute carrier family 25 member 28 "GO:0005381,GO:0005743,GO:0016021,GO:0048250,GO:0055072" iron ion transmembrane transporter activity|mitochondrial inner membrane|integral component of membrane|iron import into the mitochondrion|iron ion homeostasis SLC25A29 1162.931199 1032.21022 1293.652179 1.253283637 0.325712956 0.343540423 1 10.90484068 14.25557122 123096 solute carrier family 25 member 29 "GO:0005289,GO:0005292,GO:0005739,GO:0005743,GO:0006844,GO:0006865,GO:0015174,GO:0015227,GO:0015822,GO:0015879,GO:0016021,GO:0089709,GO:1902616,GO:1903400,GO:1903401,GO:1990575" high-affinity arginine transmembrane transporter activity|high-affinity lysine transmembrane transporter activity|mitochondrion|mitochondrial inner membrane|acyl carnitine transport|amino acid transport|basic amino acid transmembrane transporter activity|acyl carnitine transmembrane transporter activity|ornithine transport|carnitine transport|integral component of membrane|L-histidine transmembrane transport|acyl carnitine transmembrane transport|L-arginine transmembrane transport|L-lysine transmembrane transport|mitochondrial L-ornithine transmembrane transport hsa04714 Thermogenesis SLC25A3 13965.64314 13439.03198 14492.2543 1.078370401 0.108852803 0.754217045 1 111.4158716 125.3230485 5250 solute carrier family 25 member 3 "GO:0005315,GO:0005739,GO:0005743,GO:0005887,GO:0015317,GO:0016020,GO:0031305,GO:0035435,GO:0044877,GO:0070062,GO:1902600" inorganic phosphate transmembrane transporter activity|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|phosphate:proton symporter activity|membrane|integral component of mitochondrial inner membrane|phosphate ion transmembrane transport|protein-containing complex binding|extracellular exosome|proton transmembrane transport SLC25A30 334.7642473 388.7281359 280.8003587 0.722356662 -0.469216754 0.305061895 1 3.925764453 2.95795696 253512 solute carrier family 25 member 30 "GO:0003674,GO:0005515,GO:0005739,GO:0005743,GO:0006839,GO:0008150,GO:0008272,GO:0015116,GO:0015117,GO:0015131,GO:0015140,GO:0015141,GO:0015297,GO:0015709,GO:0015729,GO:0016021,GO:0035435,GO:0071422,GO:0071423,GO:1902356,GO:1902358" molecular_function|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial transport|biological_process|sulfate transport|sulfate transmembrane transporter activity|thiosulfate transmembrane transporter activity|oxaloacetate transmembrane transporter activity|malate transmembrane transporter activity|succinate transmembrane transporter activity|antiporter activity|thiosulfate transport|oxaloacetate transport|integral component of membrane|phosphate ion transmembrane transport|succinate transmembrane transport|malate transmembrane transport|oxaloacetate(2-) transmembrane transport|sulfate transmembrane transport SLC25A32 1116.768024 1277.829564 955.7064841 0.747913893 -0.419055912 0.225895448 1 22.38587323 17.46391345 81034 solute carrier family 25 member 32 "GO:0005739,GO:0005743,GO:0008517,GO:0015230,GO:0015884,GO:0016021,GO:0046655,GO:1904947,GO:1990548" mitochondrion|mitochondrial inner membrane|folic acid transmembrane transporter activity|FAD transmembrane transporter activity|folic acid transport|integral component of membrane|folic acid metabolic process|folate import into mitochondrion|mitochondrial FAD transmembrane transport SLC25A33 188.0328404 225.320225 150.7454557 0.669027628 -0.579862305 0.292391648 1 7.101228695 4.95556848 84275 solute carrier family 25 member 33 "GO:0000002,GO:0002082,GO:0005743,GO:0006390,GO:0006864,GO:0007005,GO:0008284,GO:0015218,GO:0016021,GO:0030307,GO:0031930,GO:0031966,GO:0032869,GO:0034551,GO:0051881,GO:0071156,GO:1903426,GO:1990314,GO:1990519" mitochondrial genome maintenance|regulation of oxidative phosphorylation|mitochondrial inner membrane|mitochondrial transcription|pyrimidine nucleotide transport|mitochondrion organization|positive regulation of cell population proliferation|pyrimidine nucleotide transmembrane transporter activity|integral component of membrane|positive regulation of cell growth|mitochondria-nucleus signaling pathway|mitochondrial membrane|cellular response to insulin stimulus|mitochondrial respiratory chain complex III assembly|regulation of mitochondrial membrane potential|regulation of cell cycle arrest|regulation of reactive oxygen species biosynthetic process|cellular response to insulin-like growth factor stimulus|pyrimidine nucleotide import into mitochondrion SLC25A34 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.046561539 0.035359826 284723 solute carrier family 25 member 34 "GO:0001835,GO:0005743,GO:0016021" blastocyst hatching|mitochondrial inner membrane|integral component of membrane SLC25A35 191.3476538 216.1856213 166.5096864 0.770216286 -0.376664465 0.493551045 1 2.770505835 2.225807987 399512 solute carrier family 25 member 35 "GO:0005743,GO:0016021" mitochondrial inner membrane|integral component of membrane SLC25A36 1345.451805 1486.910494 1203.993117 0.809728038 -0.304490661 0.365478246 1 13.90193299 11.74168157 55186 solute carrier family 25 member 36 "GO:0000002,GO:0005739,GO:0005743,GO:0006864,GO:0007005,GO:0015218,GO:0016021,GO:0051881,GO:1990519" mitochondrial genome maintenance|mitochondrion|mitochondrial inner membrane|pyrimidine nucleotide transport|mitochondrion organization|pyrimidine nucleotide transmembrane transporter activity|integral component of membrane|regulation of mitochondrial membrane potential|pyrimidine nucleotide import into mitochondrion SLC25A37 2417.611747 2611.481707 2223.741788 0.851524934 -0.23187932 0.467931159 1 48.21813186 42.82759424 51312 solute carrier family 25 member 37 "GO:0005381,GO:0005515,GO:0005743,GO:0016021,GO:0048250,GO:0055072" iron ion transmembrane transporter activity|protein binding|mitochondrial inner membrane|integral component of membrane|iron import into the mitochondrion|iron ion homeostasis SLC25A38 1176.078368 1089.047754 1263.108982 1.15982883 0.213911905 0.53370553 1 15.87692194 19.20773428 54977 solute carrier family 25 member 38 "GO:0005739,GO:0005743,GO:0006783,GO:0015187,GO:0016021,GO:0030218,GO:1904983" mitochondrion|mitochondrial inner membrane|heme biosynthetic process|glycine transmembrane transporter activity|integral component of membrane|erythrocyte differentiation|glycine import into mitochondrion SLC25A39 3456.330845 3571.630053 3341.031637 0.935436086 -0.096289011 0.762670624 1 114.3428965 111.5678948 51629 solute carrier family 25 member 39 "GO:0005743,GO:0006783,GO:0016021" mitochondrial inner membrane|heme biosynthetic process|integral component of membrane SLC25A4 450.9039606 414.1020351 487.7058862 1.177743273 0.236025092 0.575896038 1 4.75035271 5.83569276 291 solute carrier family 25 member 4 "GO:0000002,GO:0005471,GO:0005515,GO:0005739,GO:0005743,GO:0005887,GO:0006091,GO:0008637,GO:0015207,GO:0015853,GO:0015866,GO:0016020,GO:0016032,GO:0032592,GO:0050796,GO:0060546,GO:0140021,GO:1990544" mitochondrial genome maintenance|ATP:ADP antiporter activity|protein binding|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|generation of precursor metabolites and energy|apoptotic mitochondrial changes|adenine transmembrane transporter activity|adenine transport|ADP transport|membrane|viral process|integral component of mitochondrial membrane|regulation of insulin secretion|negative regulation of necroptotic process|mitochondrial ADP transmembrane transport|mitochondrial ATP transmembrane transport "hsa04020,hsa04022,hsa04217,hsa04218,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05164,hsa05166" Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Influenza A|Human T-cell leukemia virus 1 infection SLC25A40 598.8690508 459.7750537 737.963048 1.605052388 0.682620387 0.081452971 1 5.741120434 9.611735236 55972 solute carrier family 25 member 40 "GO:0005743,GO:0016021,GO:0055085" mitochondrial inner membrane|integral component of membrane|transmembrane transport SLC25A42 220.7895417 174.5724266 267.0066569 1.529489291 0.613050005 0.24074863 1 2.377380358 3.79280959 284439 solute carrier family 25 member 42 "GO:0005347,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0015217,GO:0015228,GO:0015866,GO:0015867,GO:0016021,GO:0035349,GO:0043262,GO:0080121,GO:0080122" ATP transmembrane transporter activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|ADP transmembrane transporter activity|coenzyme A transmembrane transporter activity|ADP transport|ATP transport|integral component of membrane|coenzyme A transmembrane transport|adenosine-diphosphatase activity|AMP transport|AMP transmembrane transporter activity SLC25A43 984.9385551 887.0715164 1082.805594 1.22065197 0.28765192 0.415976621 1 12.95100689 16.48964555 203427 solute carrier family 25 member 43 "GO:0005743,GO:0016021,GO:0055085" mitochondrial inner membrane|integral component of membrane|transmembrane transport SLC25A44 1091.476519 1131.675905 1051.277132 0.928956009 -0.106317815 0.761281162 1 7.409876181 7.179960074 9673 solute carrier family 25 member 44 "GO:0005739,GO:0009083,GO:0015658,GO:0015803,GO:0016021,GO:0031966,GO:0055085,GO:0120161" mitochondrion|branched-chain amino acid catabolic process|branched-chain amino acid transmembrane transporter activity|branched-chain amino acid transport|integral component of membrane|mitochondrial membrane|transmembrane transport|regulation of cold-induced thermogenesis SLC25A45 35.5261805 37.55337083 33.49899016 0.892036838 -0.164824806 0.889269232 1 0.600361664 0.558613815 283130 solute carrier family 25 member 45 "GO:0005743,GO:0006844,GO:0006865,GO:0015227,GO:0016021,GO:1902616" mitochondrial inner membrane|acyl carnitine transport|amino acid transport|acyl carnitine transmembrane transporter activity|integral component of membrane|acyl carnitine transmembrane transport SLC25A46 1537.068167 1519.389085 1554.747249 1.023271304 0.033188703 0.921986549 1 15.87287481 16.94190787 91137 solute carrier family 25 member 46 "GO:0005515,GO:0005739,GO:0005741,GO:0016021,GO:0090149" protein binding|mitochondrion|mitochondrial outer membrane|integral component of membrane|mitochondrial membrane fission SLC25A5 11564.68637 10888.44763 12240.92511 1.124212149 0.168914311 0.620312565 1 421.9291968 494.7704835 292 solute carrier family 25 member 5 "GO:0000295,GO:0003723,GO:0005471,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005887,GO:0007059,GO:0008284,GO:0015207,GO:0015853,GO:0016020,GO:0016032,GO:0031625,GO:0042645,GO:0045121,GO:0050796,GO:0051503,GO:0071817,GO:0140021,GO:1901029,GO:1990544,GO:1990830" adenine nucleotide transmembrane transporter activity|RNA binding|ATP:ADP antiporter activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|chromosome segregation|positive regulation of cell population proliferation|adenine transmembrane transporter activity|adenine transport|membrane|viral process|ubiquitin protein ligase binding|mitochondrial nucleoid|membrane raft|regulation of insulin secretion|adenine nucleotide transport|MMXD complex|mitochondrial ADP transmembrane transport|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|mitochondrial ATP transmembrane transport|cellular response to leukemia inhibitory factor "hsa04020,hsa04022,hsa04217,hsa04218,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05164,hsa05166" Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Influenza A|Human T-cell leukemia virus 1 infection SLC25A51 299.8224953 323.7709539 275.8740366 0.852065429 -0.230963878 0.628728209 1 14.00329344 12.44569243 92014 solute carrier family 25 member 51 "GO:0005739,GO:0005743,GO:0016021,GO:0051724,GO:1990549" mitochondrion|mitochondrial inner membrane|integral component of membrane|NAD transmembrane transporter activity|mitochondrial NAD transmembrane transport SLC25A53 50.90169938 44.65806261 57.14533616 1.279619688 0.355715095 0.686963988 1 0.285073522 0.38049918 401612 solute carrier family 25 member 53 "GO:0005743,GO:0016021" mitochondrial inner membrane|integral component of membrane SLC25A6 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.106279681 0 293 solute carrier family 25 member 6 "GO:0005471,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005744,GO:0006626,GO:0006915,GO:0016020,GO:0016021,GO:0016032,GO:0050796,GO:0140021,GO:1990544" ATP:ADP antiporter activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|protein targeting to mitochondrion|apoptotic process|membrane|integral component of membrane|viral process|regulation of insulin secretion|mitochondrial ADP transmembrane transport|mitochondrial ATP transmembrane transport "hsa04020,hsa04022,hsa04217,hsa04218,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05164,hsa05166" Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Influenza A|Human T-cell leukemia virus 1 infection SLC25A6-2 737.661927 215.1706653 1260.153189 5.856528756 2.550045813 1.34E-10 1.66E-07 7.510430821 45.87975181 293 solute carrier family 25 member 6 SLC26A1 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.037630995 0.038103707 10861 solute carrier family 26 member 1 "GO:0005886,GO:0005887,GO:0006811,GO:0006821,GO:0008271,GO:0008272,GO:0015106,GO:0015108,GO:0015116,GO:0015301,GO:0015701,GO:0016021,GO:0016323,GO:0019531,GO:0019532,GO:0050428,GO:1902358,GO:1902476" plasma membrane|integral component of plasma membrane|ion transport|chloride transport|secondary active sulfate transmembrane transporter activity|sulfate transport|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|integral component of membrane|basolateral plasma membrane|oxalate transmembrane transporter activity|oxalate transport|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|sulfate transmembrane transport|chloride transmembrane transport SLC26A11 368.5386262 306.5167024 430.56055 1.404688706 0.490250449 0.269978747 1 4.419012141 6.474723325 284129 solute carrier family 26 member 11 "GO:0005515,GO:0005654,GO:0005765,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006811,GO:0008271,GO:0008272,GO:0008509,GO:0015116,GO:0015301,GO:0016021,GO:0043231,GO:0070062,GO:1902358" protein binding|nucleoplasm|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|ion transport|secondary active sulfate transmembrane transporter activity|sulfate transport|anion transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|integral component of membrane|intracellular membrane-bounded organelle|extracellular exosome|sulfate transmembrane transport SLC26A2 1060.638882 1448.342167 672.9355965 0.464624736 -1.105862132 0.001690019 0.127258463 9.225684984 4.471125684 1836 solute carrier family 26 member 2 "GO:0001503,GO:0005886,GO:0005887,GO:0006811,GO:0008271,GO:0015106,GO:0015108,GO:0015116,GO:0015301,GO:0015701,GO:0016020,GO:0016324,GO:0019531,GO:0019532,GO:0031528,GO:0050428,GO:0070062,GO:1902358,GO:1902476" ossification|plasma membrane|integral component of plasma membrane|ion transport|secondary active sulfate transmembrane transporter activity|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|membrane|apical plasma membrane|oxalate transmembrane transporter activity|oxalate transport|microvillus membrane|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|extracellular exosome|sulfate transmembrane transport|chloride transmembrane transport SLC26A4 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.02977637 0.040200551 5172 solute carrier family 26 member 4 "GO:0005886,GO:0005887,GO:0006811,GO:0006885,GO:0007605,GO:0008271,GO:0008272,GO:0015106,GO:0015108,GO:0015111,GO:0015116,GO:0015301,GO:0015698,GO:0015701,GO:0015705,GO:0016021,GO:0016324,GO:0019531,GO:0019532,GO:0031526,GO:0032880,GO:0070062,GO:1902358,GO:1902476" plasma membrane|integral component of plasma membrane|ion transport|regulation of pH|sensory perception of sound|secondary active sulfate transmembrane transporter activity|sulfate transport|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|iodide transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|inorganic anion transport|bicarbonate transport|iodide transport|integral component of membrane|apical plasma membrane|oxalate transmembrane transporter activity|oxalate transport|brush border membrane|regulation of protein localization|extracellular exosome|sulfate transmembrane transport|chloride transmembrane transport hsa04918 Thyroid hormone synthesis SLC26A6 814.6538361 864.7424851 764.5651872 0.884153607 -0.177631059 0.629010691 1 15.41575369 14.2170148 65010 solute carrier family 26 member 6 "GO:0005254,GO:0005783,GO:0005886,GO:0005887,GO:0006811,GO:0006821,GO:0008271,GO:0008272,GO:0012506,GO:0015106,GO:0015108,GO:0015116,GO:0015301,GO:0015499,GO:0015562,GO:0015660,GO:0015701,GO:0015724,GO:0015797,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0019531,GO:0019532,GO:0030165,GO:0030321,GO:0030659,GO:0031526,GO:0031982,GO:0034707,GO:0042045,GO:0046724,GO:0048240,GO:0050892,GO:0051453,GO:0051454,GO:0070633,GO:0071320,GO:0071332,GO:0071346,GO:0097225,GO:1902358,GO:1902476,GO:2001150" chloride channel activity|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|ion transport|chloride transport|secondary active sulfate transmembrane transporter activity|sulfate transport|vesicle membrane|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|formate transmembrane transporter activity|efflux transmembrane transporter activity|formate efflux transmembrane transporter activity|bicarbonate transport|formate transport|mannitol transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|oxalate transmembrane transporter activity|oxalate transport|PDZ domain binding|transepithelial chloride transport|cytoplasmic vesicle membrane|brush border membrane|vesicle|chloride channel complex|epithelial fluid transport|oxalic acid secretion|sperm capacitation|intestinal absorption|regulation of intracellular pH|intracellular pH elevation|transepithelial transport|cellular response to cAMP|cellular response to fructose stimulus|cellular response to interferon-gamma|sperm midpiece|sulfate transmembrane transport|chloride transmembrane transport|positive regulation of dipeptide transmembrane transport hsa04978 Mineral absorption SLC26A7 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.034844223 0.035281928 115111 solute carrier family 26 member 7 "GO:0001696,GO:0005254,GO:0005737,GO:0005768,GO:0005886,GO:0005887,GO:0006811,GO:0006820,GO:0006821,GO:0008271,GO:0008272,GO:0015106,GO:0015108,GO:0015116,GO:0015301,GO:0015701,GO:0016323,GO:0019531,GO:0019532,GO:0055038,GO:1902358,GO:1902476" gastric acid secretion|chloride channel activity|cytoplasm|endosome|plasma membrane|integral component of plasma membrane|ion transport|anion transport|chloride transport|secondary active sulfate transmembrane transporter activity|sulfate transport|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|basolateral plasma membrane|oxalate transmembrane transporter activity|oxalate transport|recycling endosome membrane|sulfate transmembrane transport|chloride transmembrane transport hsa04971 Gastric acid secretion SLC27A1 213.0828541 220.2454451 205.9202631 0.934958101 -0.097026382 0.862274509 1 2.769966431 2.701360744 376497 solute carrier family 27 member 1 "GO:0000166,GO:0001579,GO:0001676,GO:0004467,GO:0005324,GO:0005515,GO:0005743,GO:0005783,GO:0005886,GO:0005887,GO:0006646,GO:0006654,GO:0006655,GO:0006656,GO:0006659,GO:0006661,GO:0009409,GO:0009925,GO:0010867,GO:0015225,GO:0015245,GO:0015562,GO:0015878,GO:0015909,GO:0015911,GO:0016020,GO:0019216,GO:0031652,GO:0031957,GO:0032049,GO:0032868,GO:0033211,GO:0044381,GO:0044539,GO:0047676,GO:0071072,GO:0071902,GO:0090434,GO:0140115,GO:0150104,GO:1905135,GO:1990379" nucleotide binding|medium-chain fatty acid transport|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity|protein binding|mitochondrial inner membrane|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|phosphatidylethanolamine biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylglycerol biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylserine biosynthetic process|phosphatidylinositol biosynthetic process|response to cold|basal plasma membrane|positive regulation of triglyceride biosynthetic process|biotin transmembrane transporter activity|fatty acid transmembrane transporter activity|efflux transmembrane transporter activity|biotin transport|long-chain fatty acid transport|long-chain fatty acid import across plasma membrane|membrane|regulation of lipid metabolic process|positive regulation of heat generation|very long-chain fatty acid-CoA ligase activity|cardiolipin biosynthetic process|response to insulin|adiponectin-activated signaling pathway|glucose import in response to insulin stimulus|long-chain fatty acid import into cell|arachidonate-CoA ligase activity|negative regulation of phospholipid biosynthetic process|positive regulation of protein serine/threonine kinase activity|oleoyl-CoA ligase activity|export across plasma membrane|transport across blood-brain barrier|biotin import across plasma membrane|lipid transport across blood-brain barrier "hsa03320,hsa04931,hsa04975" PPAR signaling pathway|Insulin resistance|Fat digestion and absorption SLC27A2 7.463712004 5.074779842 9.852644165 1.941491941 0.957165719 0.581982097 1 0.107810275 0.218329126 11001 solute carrier family 27 member 2 "GO:0001561,GO:0001676,GO:0004467,GO:0005324,GO:0005524,GO:0005778,GO:0005779,GO:0005783,GO:0005788,GO:0005789,GO:0005829,GO:0005886,GO:0006625,GO:0006635,GO:0006699,GO:0015245,GO:0019899,GO:0030176,GO:0031957,GO:0035579,GO:0042760,GO:0043312,GO:0044539,GO:0047676,GO:0047747,GO:0050197,GO:0070062,GO:0070251,GO:0097089" fatty acid alpha-oxidation|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity|ATP binding|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|cytosol|plasma membrane|protein targeting to peroxisome|fatty acid beta-oxidation|bile acid biosynthetic process|fatty acid transmembrane transporter activity|enzyme binding|integral component of endoplasmic reticulum membrane|very long-chain fatty acid-CoA ligase activity|specific granule membrane|very long-chain fatty acid catabolic process|neutrophil degranulation|long-chain fatty acid import into cell|arachidonate-CoA ligase activity|cholate-CoA ligase activity|phytanate-CoA ligase activity|extracellular exosome|pristanate-CoA ligase activity|methyl-branched fatty acid metabolic process "hsa03320,hsa04146,hsa04931" PPAR signaling pathway|Peroxisome|Insulin resistance SLC27A3 77.23389306 59.88240213 94.58538399 1.579518867 0.65948517 0.374330838 1 1.319770416 2.174398484 11000 solute carrier family 27 member 3 "GO:0001676,GO:0004467,GO:0005324,GO:0005524,GO:0005739,GO:0005783,GO:0015908,GO:0015909,GO:0016020,GO:0016021,GO:0031957,GO:0031966,GO:0047676" long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity|ATP binding|mitochondrion|endoplasmic reticulum|fatty acid transport|long-chain fatty acid transport|membrane|integral component of membrane|very long-chain fatty acid-CoA ligase activity|mitochondrial membrane|arachidonate-CoA ligase activity hsa04931 Insulin resistance SLC27A4 1502.097961 1620.884681 1383.311241 0.85342977 -0.228655658 0.490716926 1 25.33706512 22.55485427 10999 solute carrier family 27 member 4 "GO:0000166,GO:0001579,GO:0001676,GO:0004467,GO:0005324,GO:0005783,GO:0005789,GO:0005886,GO:0005902,GO:0006631,GO:0007584,GO:0015908,GO:0015909,GO:0016020,GO:0016021,GO:0031526,GO:0031957,GO:0042760,GO:0043065,GO:0043588,GO:0044381,GO:0044539,GO:0046627,GO:0047676,GO:0062003,GO:0090433,GO:0090434,GO:0090630,GO:0150104,GO:1990379" "nucleotide binding|medium-chain fatty acid transport|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|microvillus|fatty acid metabolic process|response to nutrient|fatty acid transport|long-chain fatty acid transport|membrane|integral component of membrane|brush border membrane|very long-chain fatty acid-CoA ligase activity|very long-chain fatty acid catabolic process|positive regulation of apoptotic process|skin development|glucose import in response to insulin stimulus|long-chain fatty acid import into cell|negative regulation of insulin receptor signaling pathway|arachidonate-CoA ligase activity|negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity|palmitoyl-CoA ligase activity|oleoyl-CoA ligase activity|activation of GTPase activity|transport across blood-brain barrier|lipid transport across blood-brain barrier" "hsa03320,hsa04931,hsa04975" PPAR signaling pathway|Insulin resistance|Fat digestion and absorption SLC28A1 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.029295558 0 9154 solute carrier family 28 member 1 "GO:0005337,GO:0005345,GO:0005415,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0015212,GO:0015213,GO:0015293,GO:0015389,GO:0015855,GO:0015858,GO:0015861,GO:0015862,GO:0016020,GO:0016607,GO:0031526,GO:0045117,GO:0072531,GO:1901474,GO:1901642,GO:1904823" nucleoside transmembrane transporter activity|purine nucleobase transmembrane transporter activity|nucleoside:sodium symporter activity|cytosol|plasma membrane|integral component of plasma membrane|nucleobase-containing compound metabolic process|cytidine transmembrane transporter activity|uridine transmembrane transporter activity|symporter activity|pyrimidine- and adenine-specific:sodium symporter activity|pyrimidine nucleobase transport|nucleoside transport|cytidine transport|uridine transport|membrane|nuclear speck|brush border membrane|azole transmembrane transport|pyrimidine-containing compound transmembrane transport|azole transmembrane transporter activity|nucleoside transmembrane transport|purine nucleobase transmembrane transport SLC29A1 883.1957772 970.2979058 796.0936486 0.820463122 -0.285489606 0.428734009 1 15.87792114 13.58840978 2030 solute carrier family 29 member 1 (Augustine blood group) "GO:0001504,GO:0005326,GO:0005337,GO:0005886,GO:0005887,GO:0006139,GO:0006836,GO:0007595,GO:0015211,GO:0015213,GO:0015858,GO:0015860,GO:0015862,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0030431,GO:0032238,GO:0060079,GO:0071333,GO:0071456,GO:0072531,GO:0098793,GO:0098794,GO:0098810,GO:0150104,GO:1901642" neurotransmitter uptake|neurotransmitter transmembrane transporter activity|nucleoside transmembrane transporter activity|plasma membrane|integral component of plasma membrane|nucleobase-containing compound metabolic process|neurotransmitter transport|lactation|purine nucleoside transmembrane transporter activity|uridine transmembrane transporter activity|nucleoside transport|purine nucleoside transmembrane transport|uridine transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|sleep|adenosine transport|excitatory postsynaptic potential|cellular response to glucose stimulus|cellular response to hypoxia|pyrimidine-containing compound transmembrane transport|presynapse|postsynapse|neurotransmitter reuptake|transport across blood-brain barrier|nucleoside transmembrane transport hsa05034 Alcoholism SLC29A2 33.92951766 29.43372308 38.42531225 1.30548596 0.384586942 0.705697987 1 0.388206833 0.528629397 3177 solute carrier family 29 member 2 "GO:0001504,GO:0005326,GO:0005337,GO:0005730,GO:0005886,GO:0005887,GO:0006836,GO:0015211,GO:0015213,GO:0015853,GO:0015854,GO:0015858,GO:0015860,GO:0015862,GO:0016021,GO:0016323,GO:0031965,GO:0032238,GO:0035344,GO:0035364,GO:0072531,GO:0098793,GO:0098810,GO:0150104,GO:1901642" neurotransmitter uptake|neurotransmitter transmembrane transporter activity|nucleoside transmembrane transporter activity|nucleolus|plasma membrane|integral component of plasma membrane|neurotransmitter transport|purine nucleoside transmembrane transporter activity|uridine transmembrane transporter activity|adenine transport|guanine transport|nucleoside transport|purine nucleoside transmembrane transport|uridine transport|integral component of membrane|basolateral plasma membrane|nuclear membrane|adenosine transport|hypoxanthine transport|thymine transport|pyrimidine-containing compound transmembrane transport|presynapse|neurotransmitter reuptake|transport across blood-brain barrier|nucleoside transmembrane transport hsa05034 Alcoholism SLC29A3 65.72520296 47.70293051 83.74747541 1.755604415 0.811967803 0.298631664 1 0.901823496 1.651445097 55315 solute carrier family 29 member 3 "GO:0005337,GO:0005515,GO:0005765,GO:0005794,GO:0005886,GO:0016021,GO:0031902,GO:0043231,GO:1901642" nucleoside transmembrane transporter activity|protein binding|lysosomal membrane|Golgi apparatus|plasma membrane|integral component of membrane|late endosome membrane|intracellular membrane-bounded organelle|nucleoside transmembrane transport hsa05034 Alcoholism SLC29A4 208.4480043 307.5316584 109.3643502 0.355619811 -1.491592398 0.005790948 0.296288375 5.131925401 1.903628557 222962 solute carrier family 29 member 4 "GO:0001692,GO:0005326,GO:0005337,GO:0005342,GO:0005886,GO:0006836,GO:0008324,GO:0008504,GO:0015101,GO:0015562,GO:0015695,GO:0015844,GO:0016021,GO:0016323,GO:0016324,GO:0019534,GO:0042908,GO:0042910,GO:0051610,GO:0051615,GO:0051620,GO:0051625,GO:0090494,GO:0098655,GO:0098793,GO:0140115,GO:0150104,GO:1901642,GO:1901998,GO:1903825" histamine metabolic process|neurotransmitter transmembrane transporter activity|nucleoside transmembrane transporter activity|organic acid transmembrane transporter activity|plasma membrane|neurotransmitter transport|cation transmembrane transporter activity|monoamine transmembrane transporter activity|organic cation transmembrane transporter activity|efflux transmembrane transporter activity|organic cation transport|monoamine transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|toxin transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|serotonin uptake|histamine uptake|norepinephrine uptake|epinephrine uptake|dopamine uptake|cation transmembrane transport|presynapse|export across plasma membrane|transport across blood-brain barrier|nucleoside transmembrane transport|toxin transport|organic acid transmembrane transport SLC2A1 5190.057747 7185.888256 3194.227238 0.444513903 -1.169699551 0.000328431 0.041898412 107.5472488 49.86554661 6513 solute carrier family 2 member 1 "GO:0000139,GO:0001666,GO:0001917,GO:0001939,GO:0005324,GO:0005355,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0005901,GO:0005989,GO:0007417,GO:0007565,GO:0010827,GO:0014704,GO:0015911,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0019852,GO:0019900,GO:0021987,GO:0030018,GO:0030496,GO:0030864,GO:0032868,GO:0033300,GO:0042149,GO:0042383,GO:0042470,GO:0042802,GO:0042908,GO:0042910,GO:0043621,GO:0045494,GO:0050796,GO:0055056,GO:0065003,GO:0070062,GO:0070837,GO:0071260,GO:0071474,GO:0072562,GO:0098708,GO:0098793,GO:0150104,GO:1904016,GO:1904659" Golgi membrane|response to hypoxia|photoreceptor inner segment|female pronucleus|long-chain fatty acid transporter activity|glucose transmembrane transporter activity|protein binding|cytosol|plasma membrane|integral component of plasma membrane|caveola|lactose biosynthetic process|central nervous system development|female pregnancy|regulation of glucose transmembrane transport|intercalated disc|long-chain fatty acid import across plasma membrane|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|L-ascorbic acid metabolic process|kinase binding|cerebral cortex development|Z disc|midbody|cortical actin cytoskeleton|response to insulin|dehydroascorbic acid transmembrane transporter activity|cellular response to glucose starvation|sarcolemma|melanosome|identical protein binding|xenobiotic transport|xenobiotic transmembrane transporter activity|protein self-association|photoreceptor cell maintenance|regulation of insulin secretion|D-glucose transmembrane transporter activity|protein-containing complex assembly|extracellular exosome|dehydroascorbic acid transport|cellular response to mechanical stimulus|cellular hyperosmotic response|blood microparticle|glucose import across plasma membrane|presynapse|transport across blood-brain barrier|response to Thyroglobulin triiodothyronine|glucose transmembrane transport "hsa04066,hsa04911,hsa04919,hsa04920,hsa04922,hsa04931,hsa04976,hsa05166,hsa05200,hsa05211,hsa05230" HIF-1 signaling pathway|Insulin secretion|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Bile secretion|Human T-cell leukemia virus 1 infection|Pathways in cancer|Renal cell carcinoma|Central carbon metabolism in cancer SLC2A10 944.5075792 952.0286983 936.9864601 0.984199806 -0.022976863 0.951692225 1 7.239774026 7.432316845 81031 solute carrier family 2 member 10 "GO:0005351,GO:0005886,GO:0005887,GO:0008645,GO:0010628,GO:0010629,GO:0012505,GO:0015757,GO:0016021,GO:0030511,GO:0030512,GO:0032683,GO:0033300,GO:0043588,GO:0045454,GO:0048471,GO:0055056,GO:0060392,GO:0060840,GO:0070837,GO:0072498,GO:0098708,GO:0150104,GO:1902600,GO:1902729,GO:1902730,GO:1903053,GO:1904659,GO:2001045" carbohydrate:proton symporter activity|plasma membrane|integral component of plasma membrane|hexose transmembrane transport|positive regulation of gene expression|negative regulation of gene expression|endomembrane system|galactose transmembrane transport|integral component of membrane|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of connective tissue growth factor production|dehydroascorbic acid transmembrane transporter activity|skin development|cell redox homeostasis|perinuclear region of cytoplasm|D-glucose transmembrane transporter activity|negative regulation of SMAD protein signal transduction|artery development|dehydroascorbic acid transport|embryonic skeletal joint development|glucose import across plasma membrane|transport across blood-brain barrier|proton transmembrane transport|negative regulation of proteoglycan biosynthetic process|positive regulation of proteoglycan biosynthetic process|regulation of extracellular matrix organization|glucose transmembrane transport|negative regulation of integrin-mediated signaling pathway SLC2A11 394.1594604 441.5058462 346.8130746 0.785523176 -0.348274253 0.424883108 1 6.165071291 5.05141484 66035 solute carrier family 2 member 11 "GO:0005355,GO:0005654,GO:0005886,GO:0008645,GO:0016021,GO:0030054,GO:1904659" glucose transmembrane transporter activity|nucleoplasm|plasma membrane|hexose transmembrane transport|integral component of membrane|cell junction|glucose transmembrane transport SLC2A12 91.05456484 95.40586103 86.70326866 0.908783462 -0.137991514 0.857633083 1 0.573391514 0.543535114 154091 solute carrier family 2 member 12 "GO:0005886,GO:0008645,GO:0012505,GO:0016021,GO:0022857,GO:0048471,GO:1904659" plasma membrane|hexose transmembrane transport|endomembrane system|integral component of membrane|transmembrane transporter activity|perinuclear region of cytoplasm|glucose transmembrane transport SLC2A13 227.3461776 319.71113 134.9812251 0.422197454 -1.244010217 0.01716081 0.570200991 1.15807759 0.509998851 114134 solute carrier family 2 member 13 "GO:0002020,GO:0005365,GO:0005366,GO:0005515,GO:0005737,GO:0005764,GO:0005769,GO:0005886,GO:0005887,GO:0008021,GO:0015798,GO:0016020,GO:0030426,GO:0031090,GO:0042995,GO:0043231,GO:0044297,GO:0051117,GO:0055085,GO:0071944,GO:0097450,GO:0150104,GO:1902004" protease binding|myo-inositol transmembrane transporter activity|myo-inositol:proton symporter activity|protein binding|cytoplasm|lysosome|early endosome|plasma membrane|integral component of plasma membrane|synaptic vesicle|myo-inositol transport|membrane|growth cone|organelle membrane|cell projection|intracellular membrane-bounded organelle|cell body|ATPase binding|transmembrane transport|cell periphery|astrocyte end-foot|transport across blood-brain barrier|positive regulation of amyloid-beta formation SLC2A3 1073.455484 1347.861526 799.0494418 0.592827547 -0.754315608 0.030795566 0.785916967 17.83758331 11.0301221 6515 solute carrier family 2 member 3 "GO:0005355,GO:0005515,GO:0005536,GO:0005886,GO:0005887,GO:0005975,GO:0016021,GO:0019852,GO:0030667,GO:0035579,GO:0042995,GO:0043204,GO:0043312,GO:0070062,GO:0070821,GO:0098708,GO:0101003,GO:0150104,GO:1904659" glucose transmembrane transporter activity|protein binding|glucose binding|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|integral component of membrane|L-ascorbic acid metabolic process|secretory granule membrane|specific granule membrane|cell projection|perikaryon|neutrophil degranulation|extracellular exosome|tertiary granule membrane|glucose import across plasma membrane|ficolin-1-rich granule membrane|transport across blood-brain barrier|glucose transmembrane transport SLC2A4 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.015230797 0.046266368 6517 solute carrier family 2 member 4 "GO:0005355,GO:0005515,GO:0005771,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0005905,GO:0005975,GO:0007611,GO:0007614,GO:0007616,GO:0009897,GO:0010021,GO:0012505,GO:0012506,GO:0016020,GO:0016529,GO:0030136,GO:0030140,GO:0030315,GO:0030659,GO:0031550,GO:0032593,GO:0032869,GO:0042383,GO:0042593,GO:0044381,GO:0045121,GO:0045471,GO:0046323,GO:0048471,GO:0050873,GO:0055056,GO:0070062,GO:0071356,GO:0071456,GO:0071470,GO:0098694,GO:0098793,GO:0150104,GO:1904659" glucose transmembrane transporter activity|protein binding|multivesicular body|trans-Golgi network|cytosol|plasma membrane|integral component of plasma membrane|clathrin-coated pit|carbohydrate metabolic process|learning or memory|short-term memory|long-term memory|external side of plasma membrane|amylopectin biosynthetic process|endomembrane system|vesicle membrane|membrane|sarcoplasmic reticulum|clathrin-coated vesicle|trans-Golgi network transport vesicle|T-tubule|cytoplasmic vesicle membrane|positive regulation of brain-derived neurotrophic factor receptor signaling pathway|insulin-responsive compartment|cellular response to insulin stimulus|sarcolemma|glucose homeostasis|glucose import in response to insulin stimulus|membrane raft|response to ethanol|glucose import|perinuclear region of cytoplasm|brown fat cell differentiation|D-glucose transmembrane transporter activity|extracellular exosome|cellular response to tumor necrosis factor|cellular response to hypoxia|cellular response to osmotic stress|regulation of synaptic vesicle budding from presynaptic endocytic zone membrane|presynapse|transport across blood-brain barrier|glucose transmembrane transport "hsa04068,hsa04152,hsa04910,hsa04920,hsa04930,hsa04931" FoxO signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance SLC2A4RG 3286.72408 2922.058233 3651.389928 1.249595195 0.321460811 0.312307546 1 62.68188949 81.70099691 56731 SLC2A4 regulator "GO:0000978,GO:0003700,GO:0005634,GO:0005737,GO:0006355,GO:0006357,GO:0016607,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nuclear speck|metal ion binding" SLC2A6 1459.090501 1610.735122 1307.445881 0.811707563 -0.300968039 0.365820841 1 30.43957149 25.77235214 11182 solute carrier family 2 member 6 "GO:0005353,GO:0005355,GO:0005515,GO:0005765,GO:0005886,GO:0006110,GO:0008645,GO:0015755,GO:0016020,GO:0016021,GO:0033300,GO:0070837,GO:1904659" fructose transmembrane transporter activity|glucose transmembrane transporter activity|protein binding|lysosomal membrane|plasma membrane|regulation of glycolytic process|hexose transmembrane transport|fructose transmembrane transport|membrane|integral component of membrane|dehydroascorbic acid transmembrane transporter activity|dehydroascorbic acid transport|glucose transmembrane transport SLC2A8 307.1256253 284.1876711 330.0635795 1.161428215 0.215899987 0.649200394 1 6.203923702 7.515791958 29988 solute carrier family 2 member 8 "GO:0001666,GO:0005353,GO:0005355,GO:0005536,GO:0005765,GO:0005886,GO:0005887,GO:0005975,GO:0007141,GO:0008021,GO:0008286,GO:0008645,GO:0015755,GO:0030665,GO:0033300,GO:0061024,GO:0070837,GO:1904659" response to hypoxia|fructose transmembrane transporter activity|glucose transmembrane transporter activity|glucose binding|lysosomal membrane|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|male meiosis I|synaptic vesicle|insulin receptor signaling pathway|hexose transmembrane transport|fructose transmembrane transport|clathrin-coated vesicle membrane|dehydroascorbic acid transmembrane transporter activity|membrane organization|dehydroascorbic acid transport|glucose transmembrane transport SLC30A1 625.9108741 927.6697551 324.151993 0.349426066 -1.516940863 0.000122095 0.018805381 7.972713469 2.905878052 7779 solute carrier family 30 member 1 "GO:0001701,GO:0005385,GO:0005515,GO:0005737,GO:0005783,GO:0005794,GO:0005886,GO:0006829,GO:0006874,GO:0006882,GO:0019855,GO:0030315,GO:0031965,GO:0046929,GO:0070509,GO:0070574,GO:0071577,GO:0071584,GO:0071585,GO:0090281,GO:0098685,GO:0099061" in utero embryonic development|zinc ion transmembrane transporter activity|protein binding|cytoplasm|endoplasmic reticulum|Golgi apparatus|plasma membrane|zinc ion transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|calcium channel inhibitor activity|T-tubule|nuclear membrane|negative regulation of neurotransmitter secretion|calcium ion import|cadmium ion transmembrane transport|zinc ion transmembrane transport|negative regulation of zinc ion transmembrane import|detoxification of cadmium ion|negative regulation of calcium ion import|Schaffer collateral - CA1 synapse|integral component of postsynaptic density membrane hsa04978 Mineral absorption SLC30A4 254.8526714 213.1407534 296.5645894 1.391402558 0.476539878 0.339677416 1 1.199691847 1.74115901 7782 solute carrier family 30 member 4 "GO:0005385,GO:0005515,GO:0005737,GO:0005765,GO:0005770,GO:0005886,GO:0009636,GO:0010043,GO:0016021,GO:0031902,GO:0055069,GO:0061088,GO:0071577" zinc ion transmembrane transporter activity|protein binding|cytoplasm|lysosomal membrane|late endosome|plasma membrane|response to toxic substance|response to zinc ion|integral component of membrane|late endosome membrane|zinc ion homeostasis|regulation of sequestering of zinc ion|zinc ion transmembrane transport SLC30A5 1571.316127 1671.63248 1470.999774 0.879977981 -0.184460671 0.576439828 1 17.99028643 16.51299361 64924 solute carrier family 30 member 5 "GO:0005385,GO:0005654,GO:0005730,GO:0005794,GO:0005887,GO:0006824,GO:0006829,GO:0006882,GO:0008270,GO:0010043,GO:0010155,GO:0016020,GO:0016324,GO:0030141,GO:0030667,GO:0071577" zinc ion transmembrane transporter activity|nucleoplasm|nucleolus|Golgi apparatus|integral component of plasma membrane|cobalt ion transport|zinc ion transport|cellular zinc ion homeostasis|zinc ion binding|response to zinc ion|regulation of proton transport|membrane|apical plasma membrane|secretory granule|secretory granule membrane|zinc ion transmembrane transport SLC30A6 654.6658969 704.3794421 604.9523518 0.858844418 -0.219531288 0.568243468 1 5.108008854 4.575958407 55676 solute carrier family 30 member 6 "GO:0000139,GO:0005385,GO:0005794,GO:0016021,GO:0071577" Golgi membrane|zinc ion transmembrane transporter activity|Golgi apparatus|integral component of membrane|zinc ion transmembrane transport SLC30A7 891.2290719 946.9539185 835.5042252 0.882307163 -0.180647098 0.616922953 1 4.891868148 4.502051696 148867 solute carrier family 30 member 7 "GO:0005737,GO:0005794,GO:0006829,GO:0008324,GO:0016021,GO:0031410,GO:0031982,GO:0032119,GO:0048471,GO:0098655" cytoplasm|Golgi apparatus|zinc ion transport|cation transmembrane transporter activity|integral component of membrane|cytoplasmic vesicle|vesicle|sequestering of zinc ion|perinuclear region of cytoplasm|cation transmembrane transport SLC30A9 1195.829431 1260.575313 1131.08355 0.897275664 -0.156376813 0.648865165 1 10.31067386 9.65003455 10463 solute carrier family 30 member 9 "GO:0003682,GO:0005634,GO:0005783,GO:0005856,GO:0006289,GO:0006829,GO:0006882,GO:0008324,GO:0016021,GO:0016922,GO:0030374,GO:0031410,GO:0045944,GO:0098655" chromatin binding|nucleus|endoplasmic reticulum|cytoskeleton|nucleotide-excision repair|zinc ion transport|cellular zinc ion homeostasis|cation transmembrane transporter activity|integral component of membrane|nuclear receptor binding|nuclear receptor coactivator activity|cytoplasmic vesicle|positive regulation of transcription by RNA polymerase II|cation transmembrane transport SLC31A1 1603.013335 1615.809902 1590.216768 0.984160802 -0.023034039 0.946153168 1 17.18502127 17.64136019 1317 solute carrier family 31 member 1 "GO:0005375,GO:0005770,GO:0005886,GO:0005887,GO:0006825,GO:0006878,GO:0042802,GO:0043025,GO:0055037,GO:0072719,GO:0098705" copper ion transmembrane transporter activity|late endosome|plasma membrane|integral component of plasma membrane|copper ion transport|cellular copper ion homeostasis|identical protein binding|neuronal cell body|recycling endosome|cellular response to cisplatin|copper ion import across plasma membrane "hsa01524,hsa04978" Platinum drug resistance|Mineral absorption SLC31A2 310.2716921 330.8756457 289.6677385 0.875458022 -0.191890091 0.68575524 1 7.487794546 6.837623382 1318 solute carrier family 31 member 2 "GO:0005375,GO:0005515,GO:0005770,GO:0005886,GO:0005887,GO:0006825,GO:0006878,GO:0035434,GO:0055037,GO:1902311" copper ion transmembrane transporter activity|protein binding|late endosome|plasma membrane|integral component of plasma membrane|copper ion transport|cellular copper ion homeostasis|copper ion transmembrane transport|recycling endosome|regulation of copper ion transmembrane transport SLC33A1 728.6052655 707.42431 749.786221 1.059881899 0.083903516 0.825761858 1 3.819267206 4.222342403 9197 solute carrier family 33 member 1 "GO:0000139,GO:0005789,GO:0005887,GO:0008521,GO:0015295,GO:0015876,GO:0016020,GO:0030509,GO:0055085,GO:0060395,GO:1902600" Golgi membrane|endoplasmic reticulum membrane|integral component of plasma membrane|acetyl-CoA transmembrane transporter activity|solute:proton symporter activity|acetyl-CoA transport|membrane|BMP signaling pathway|transmembrane transport|SMAD protein signal transduction|proton transmembrane transport hsa00604 Glycosphingolipid biosynthesis - ganglio series SLC35A1 369.4024028 331.8906017 406.914204 1.226049192 0.294016865 0.509431778 1 9.066390579 11.59466619 10559 solute carrier family 35 member A1 "GO:0000139,GO:0005456,GO:0005459,GO:0005515,GO:0005794,GO:0005887,GO:0005975,GO:0006464,GO:0008643,GO:0015297,GO:0015782,GO:0016021,GO:0030173,GO:0072334" Golgi membrane|CMP-N-acetylneuraminate transmembrane transporter activity|UDP-galactose transmembrane transporter activity|protein binding|Golgi apparatus|integral component of plasma membrane|carbohydrate metabolic process|cellular protein modification process|carbohydrate transport|antiporter activity|CMP-N-acetylneuraminate transmembrane transport|integral component of membrane|integral component of Golgi membrane|UDP-galactose transmembrane transport SLC35A2 1327.212289 1452.401991 1202.022588 0.827610122 -0.272976806 0.418186042 1 24.85942449 21.46015198 7355 solute carrier family 35 member A2 "GO:0000139,GO:0005459,GO:0005654,GO:0005783,GO:0005794,GO:0006012,GO:0008643,GO:0030173,GO:0072334" Golgi membrane|UDP-galactose transmembrane transporter activity|nucleoplasm|endoplasmic reticulum|Golgi apparatus|galactose metabolic process|carbohydrate transport|integral component of Golgi membrane|UDP-galactose transmembrane transport SLC35A3 880.9216518 848.5031896 913.3401141 1.076413295 0.106232115 0.770534647 1 2.624187421 2.94638729 23443 solute carrier family 35 member A3 "GO:0000139,GO:0005459,GO:0005462,GO:0005515,GO:0005794,GO:0006047,GO:0008643,GO:0030173,GO:0072334,GO:1990569" Golgi membrane|UDP-galactose transmembrane transporter activity|UDP-N-acetylglucosamine transmembrane transporter activity|protein binding|Golgi apparatus|UDP-N-acetylglucosamine metabolic process|carbohydrate transport|integral component of Golgi membrane|UDP-galactose transmembrane transport|UDP-N-acetylglucosamine transmembrane transport SLC35A4 1787.577215 2277.561193 1297.593237 0.569729253 -0.811651612 0.012982839 0.50554854 43.26723169 25.71245578 113829 solute carrier family 35 member A4 "GO:0005515,GO:0005794,GO:0008643,GO:0015165,GO:0030173,GO:0090481" protein binding|Golgi apparatus|carbohydrate transport|pyrimidine nucleotide-sugar transmembrane transporter activity|integral component of Golgi membrane|pyrimidine nucleotide-sugar transmembrane transport SLC35A5 632.9564288 567.3603863 698.5524713 1.231232367 0.300103063 0.437880475 1 6.206220743 7.970456062 55032 solute carrier family 35 member A5 "GO:0005515,GO:0008643,GO:0015165,GO:0030173,GO:0090481" protein binding|carbohydrate transport|pyrimidine nucleotide-sugar transmembrane transporter activity|integral component of Golgi membrane|pyrimidine nucleotide-sugar transmembrane transport SLC35B1 1106.237917 1164.154496 1048.321339 0.900500185 -0.151201522 0.663858524 1 33.17969517 31.16535857 10237 solute carrier family 35 member B1 "GO:0005459,GO:0005460,GO:0005515,GO:0008643,GO:0015786,GO:0022857,GO:0030173,GO:0030176,GO:0043231,GO:0072334" UDP-galactose transmembrane transporter activity|UDP-glucose transmembrane transporter activity|protein binding|carbohydrate transport|UDP-glucose transmembrane transport|transmembrane transporter activity|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|intracellular membrane-bounded organelle|UDP-galactose transmembrane transport SLC35B2 1599.087123 1616.824858 1581.349389 0.978058558 -0.032007251 0.924405748 1 36.31329278 37.0464347 347734 solute carrier family 35 member B2 "GO:0000139,GO:0005515,GO:0005794,GO:0016020,GO:0016021,GO:0022857,GO:0030173,GO:0030176,GO:0043123,GO:0046963,GO:0046964,GO:0050428,GO:1902559" Golgi membrane|protein binding|Golgi apparatus|membrane|integral component of membrane|transmembrane transporter activity|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|3'-phosphoadenosine 5'-phosphosulfate transport|3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|3'-phospho-5'-adenylyl sulfate transmembrane transport SLC35B3 230.6961258 245.6193443 215.7729072 0.87848499 -0.186910459 0.721897045 1 2.740033766 2.510765716 51000 solute carrier family 35 member B3 "GO:0000139,GO:0022857,GO:0030173,GO:0030176,GO:0046964,GO:0050428,GO:1902559" Golgi membrane|transmembrane transporter activity|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|3'-phospho-5'-adenylyl sulfate transmembrane transport SLC35B4 1544.368575 1513.299349 1575.437802 1.041061574 0.0580554 0.862219977 1 11.19697201 12.15886227 84912 solute carrier family 35 member B4 "GO:0000139,GO:0005462,GO:0005464,GO:0005515,GO:0005783,GO:0005794,GO:0006111,GO:0008643,GO:0015790,GO:0022857,GO:0030173,GO:0030176,GO:1990569" Golgi membrane|UDP-N-acetylglucosamine transmembrane transporter activity|UDP-xylose transmembrane transporter activity|protein binding|endoplasmic reticulum|Golgi apparatus|regulation of gluconeogenesis|carbohydrate transport|UDP-xylose transmembrane transport|transmembrane transporter activity|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|UDP-N-acetylglucosamine transmembrane transport SLC35C1 865.1789479 951.0137424 779.3441535 0.819487794 -0.287205634 0.42777678 1 11.47890636 9.812031457 55343 solute carrier family 35 member C1 "GO:0000139,GO:0005457,GO:0005794,GO:0008643,GO:0015297,GO:0016021,GO:0030259,GO:0036066,GO:0036085,GO:0045746" Golgi membrane|GDP-fucose transmembrane transporter activity|Golgi apparatus|carbohydrate transport|antiporter activity|integral component of membrane|lipid glycosylation|protein O-linked fucosylation|GDP-fucose import into Golgi lumen|negative regulation of Notch signaling pathway SLC35C2 1633.9831 1510.254481 1757.711719 1.163851352 0.218906808 0.505227987 1 11.64394301 14.1355762 51006 solute carrier family 35 member C2 "GO:0005654,GO:0005793,GO:0005794,GO:0005801,GO:0010629,GO:0015297,GO:0015786,GO:0016021,GO:0033116,GO:0036066,GO:0045747" nucleoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|negative regulation of gene expression|antiporter activity|UDP-glucose transmembrane transport|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|protein O-linked fucosylation|positive regulation of Notch signaling pathway SLC35D1 684.0011428 689.1551025 678.847183 0.985042671 -0.021741873 0.958474295 1 5.33607625 5.482681286 23169 solute carrier family 35 member D1 "GO:0005461,GO:0005462,GO:0005463,GO:0005789,GO:0005794,GO:0006065,GO:0008643,GO:0015297,GO:0015787,GO:0015789,GO:0016021,GO:1990569" UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylglucosamine transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity|endoplasmic reticulum membrane|Golgi apparatus|UDP-glucuronate biosynthetic process|carbohydrate transport|antiporter activity|UDP-glucuronic acid transmembrane transport|UDP-N-acetylgalactosamine transmembrane transport|integral component of membrane|UDP-N-acetylglucosamine transmembrane transport SLC35D2 743.2560629 631.3026123 855.2095136 1.354674441 0.437946181 0.240443973 1 19.65165963 27.76835163 11046 solute carrier family 35 member D2 "GO:0000139,GO:0005338,GO:0005461,GO:0005462,GO:0005463,GO:0005794,GO:0006024,GO:0008150,GO:0008643,GO:0015297,GO:0015787,GO:0015789,GO:0016021,GO:0018146,GO:1990569" Golgi membrane|nucleotide-sugar transmembrane transporter activity|UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylglucosamine transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity|Golgi apparatus|glycosaminoglycan biosynthetic process|biological_process|carbohydrate transport|antiporter activity|UDP-glucuronic acid transmembrane transport|UDP-N-acetylgalactosamine transmembrane transport|integral component of membrane|keratan sulfate biosynthetic process|UDP-N-acetylglucosamine transmembrane transport SLC35D3 3.552345889 7.104691779 0 0 #NAME? 0.089820349 1 0.153575576 0 340146 solute carrier family 35 member D3 "GO:0005461,GO:0005462,GO:0005463,GO:0005769,GO:0005783,GO:0005794,GO:0008643,GO:0015297,GO:0015787,GO:0015789,GO:0016021,GO:0070863,GO:0097009,GO:1990569" UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylglucosamine transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity|early endosome|endoplasmic reticulum|Golgi apparatus|carbohydrate transport|antiporter activity|UDP-glucuronic acid transmembrane transport|UDP-N-acetylgalactosamine transmembrane transport|integral component of membrane|positive regulation of protein exit from endoplasmic reticulum|energy homeostasis|UDP-N-acetylglucosamine transmembrane transport SLC35E1 1610.613134 1966.984667 1254.241602 0.637646863 -0.649170433 0.048805975 1 19.43441948 12.9261065 79939 solute carrier family 35 member E1 "GO:0005515,GO:0005794,GO:0015297,GO:0016021,GO:0055085" protein binding|Golgi apparatus|antiporter activity|integral component of membrane|transmembrane transport SLC35E2A 442.7815913 431.3562866 454.206896 1.052973864 0.074469628 0.864700897 1 2.965075215 3.256636125 9906 solute carrier family 35 member E2A "GO:0005515,GO:0005794,GO:0015297,GO:0016021,GO:0055085" protein binding|Golgi apparatus|antiporter activity|integral component of membrane|transmembrane transport SLC35E2B 2320.128962 2076.599911 2563.658012 1.234545951 0.303980536 0.341847107 1 15.66698342 20.1747691 728661 solute carrier family 35 member E2B "GO:0001835,GO:0005794,GO:0015297,GO:0016021,GO:0055085" blastocyst hatching|Golgi apparatus|antiporter activity|integral component of membrane|transmembrane transport SLC35E3 915.9294679 1019.015792 812.8431437 0.797674727 -0.326127526 0.362513829 1 2.855458394 2.375842235 55508 solute carrier family 35 member E3 "GO:0005338,GO:0005515,GO:0005794,GO:0015297,GO:0015931,GO:0016021,GO:0055085,GO:1901264" nucleotide-sugar transmembrane transporter activity|protein binding|Golgi apparatus|antiporter activity|nucleobase-containing compound transport|integral component of membrane|transmembrane transport|carbohydrate derivative transport SLC35E4 416.9568756 417.146903 416.7668482 0.999088919 -0.001315012 1 1 3.499589039 3.647011388 339665 solute carrier family 35 member E4 "GO:0005515,GO:0005794,GO:0015297,GO:0016021,GO:0055085" protein binding|Golgi apparatus|antiporter activity|integral component of membrane|transmembrane transport SLC35F2 1247.867575 1281.889388 1213.845761 0.946919268 -0.078686664 0.818867406 1 23.44643383 23.15824691 54733 solute carrier family 35 member F2 "GO:0003674,GO:0005575,GO:0008150,GO:0016021,GO:0022857,GO:0055085" molecular_function|cellular_component|biological_process|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC35F3 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.044073112 0.044626748 148641 solute carrier family 35 member F3 "GO:0015888,GO:0016021" thiamine transport|integral component of membrane SLC35F5 999.4366893 1036.270044 962.603335 0.928911668 -0.10638668 0.764727638 1 3.60760393 3.495499137 80255 solute carrier family 35 member F5 GO:0016021 integral component of membrane SLC35F6 680.861757 743.9627248 617.7607892 0.830365244 -0.268182037 0.481209859 1 9.656352504 8.363695321 54978 solute carrier family 35 member F6 "GO:0005515,GO:0005654,GO:0005739,GO:0005765,GO:0005829,GO:0008284,GO:0016020,GO:0016021,GO:0022857,GO:0043231,GO:0055085,GO:0070062,GO:1901029" protein binding|nucleoplasm|mitochondrion|lysosomal membrane|cytosol|positive regulation of cell population proliferation|membrane|integral component of membrane|transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport|extracellular exosome|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway SLC35G1 392.7261011 444.5507141 340.9014881 0.76684499 -0.382993113 0.380387478 1 4.285292233 3.427709106 159371 solute carrier family 35 member G1 "GO:0005515,GO:0005789,GO:0005886,GO:0016021,GO:0051480,GO:1990034" protein binding|endoplasmic reticulum membrane|plasma membrane|integral component of membrane|regulation of cytosolic calcium ion concentration|calcium ion export across plasma membrane SLC35G2 278.615062 254.7539481 302.4761759 1.187326745 0.24771701 0.6122967 1 1.819287754 2.253136881 80723 solute carrier family 35 member G2 "GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0016021" protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|integral component of membrane SLC36A1 390.3965521 453.6853179 327.1077863 0.721001481 -0.471925871 0.280135666 1 1.871746566 1.407664414 206358 solute carrier family 36 member 1 "GO:0003333,GO:0005280,GO:0005368,GO:0005515,GO:0005765,GO:0005783,GO:0005886,GO:0006811,GO:0006865,GO:0015171,GO:0015180,GO:0015187,GO:0015193,GO:0015734,GO:0015808,GO:0015816,GO:0015824,GO:0016021,GO:0022858,GO:0032328,GO:0035524,GO:0089718,GO:1902600" amino acid transmembrane transport|amino acid:proton symporter activity|taurine transmembrane transporter activity|protein binding|lysosomal membrane|endoplasmic reticulum|plasma membrane|ion transport|amino acid transport|amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|glycine transmembrane transporter activity|L-proline transmembrane transporter activity|taurine transport|L-alanine transport|glycine transport|proline transport|integral component of membrane|alanine transmembrane transporter activity|alanine transport|proline transmembrane transport|amino acid import across plasma membrane|proton transmembrane transport hsa04974 Protein digestion and absorption SLC36A4 676.3674463 571.4202102 781.3146823 1.367320701 0.451351662 0.235768981 1 4.353906694 6.209625894 120103 solute carrier family 36 member 4 "GO:0003333,GO:0005886,GO:0015171,GO:0015180,GO:0015193,GO:0015196,GO:0015293,GO:0015808,GO:0015824,GO:0015827,GO:0016021,GO:1904271,GO:1904556" amino acid transmembrane transport|plasma membrane|amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-proline transmembrane transporter activity|L-tryptophan transmembrane transporter activity|symporter activity|L-alanine transport|proline transport|tryptophan transport|integral component of membrane|L-proline import across plasma membrane|L-tryptophan transmembrane transport hsa04974 Protein digestion and absorption SLC37A1 177.8765997 103.5255088 252.2276906 2.436382044 1.284740377 0.023202289 0.669114512 0.467142 1.187162679 54020 solute carrier family 37 member 1 "GO:0005789,GO:0008643,GO:0015760,GO:0016020,GO:0030176,GO:0035435,GO:0061513" endoplasmic reticulum membrane|carbohydrate transport|glucose-6-phosphate transport|membrane|integral component of endoplasmic reticulum membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity SLC37A2 828.6417708 1046.419603 610.8639383 0.583765763 -0.776538493 0.03383395 0.826279917 13.2229195 8.051594685 219855 solute carrier family 37 member 2 "GO:0005789,GO:0008643,GO:0015760,GO:0030176,GO:0035435,GO:0061513,GO:0070062" endoplasmic reticulum membrane|carbohydrate transport|glucose-6-phosphate transport|integral component of endoplasmic reticulum membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity|extracellular exosome SLC37A3 762.015181 701.3345741 822.6957878 1.173043249 0.230256206 0.535956279 1 10.66670331 13.05149225 84255 solute carrier family 37 member 3 "GO:0008643,GO:0015760,GO:0030176,GO:0035435,GO:0061513" carbohydrate transport|glucose-6-phosphate transport|integral component of endoplasmic reticulum membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity SLC37A4 954.3453776 951.0137424 957.6770129 1.007006492 0.010072985 0.980675721 1 16.15207615 16.96588636 2542 solute carrier family 37 member 4 "GO:0005515,GO:0005783,GO:0005789,GO:0006006,GO:0006094,GO:0008643,GO:0015152,GO:0015760,GO:0016020,GO:0016021,GO:0030176,GO:0035435,GO:0061513" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|glucose metabolic process|gluconeogenesis|carbohydrate transport|glucose-6-phosphate transmembrane transporter activity|glucose-6-phosphate transport|membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity hsa04973 Carbohydrate digestion and absorption SLC38A1 7219.402562 7569.541612 6869.263512 0.907487384 -0.140050509 0.669715749 1 34.70987586 32.85561389 81539 solute carrier family 38 member 1 "GO:0001504,GO:0003333,GO:0005283,GO:0005295,GO:0005515,GO:0005886,GO:0005887,GO:0006814,GO:0006865,GO:0006868,GO:0015171,GO:0015175,GO:0015179,GO:0015186,GO:0015804,GO:0015807,GO:0016021,GO:0016323,GO:0043025,GO:0070062,GO:0098591,GO:0150104,GO:1902475" neurotransmitter uptake|amino acid transmembrane transport|amino acid:sodium symporter activity|neutral amino acid:sodium symporter activity|protein binding|plasma membrane|integral component of plasma membrane|sodium ion transport|amino acid transport|glutamine transport|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-glutamine transmembrane transporter activity|neutral amino acid transport|L-amino acid transport|integral component of membrane|basolateral plasma membrane|neuronal cell body|extracellular exosome|external side of apical plasma membrane|transport across blood-brain barrier|L-alpha-amino acid transmembrane transport "hsa04724,hsa04727" Glutamatergic synapse|GABAergic synapse SLC38A10 1083.644384 1067.733679 1099.555089 1.02980276 0.042368041 0.905586021 1 10.47191016 11.24853306 124565 solute carrier family 38 member 10 "GO:0003333,GO:0005794,GO:0006814,GO:0015171,GO:0016021,GO:0060348" amino acid transmembrane transport|Golgi apparatus|sodium ion transport|amino acid transmembrane transporter activity|integral component of membrane|bone development SLC38A2 9349.708526 8119.647747 10579.7693 1.302983779 0.381819124 0.254190592 1 85.76256809 116.5608527 54407 solute carrier family 38 member 2 "GO:0003333,GO:0005295,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0005903,GO:0006814,GO:0006865,GO:0006868,GO:0007565,GO:0010628,GO:0014047,GO:0015171,GO:0015186,GO:0015194,GO:0015804,GO:0015825,GO:0021987,GO:0030424,GO:0030425,GO:0031460,GO:0032328,GO:0033120,GO:0034198,GO:0042383,GO:0043025,GO:0071260,GO:0080135,GO:0150104,GO:1903841" amino acid transmembrane transport|neutral amino acid:sodium symporter activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|brush border|sodium ion transport|amino acid transport|glutamine transport|female pregnancy|positive regulation of gene expression|glutamate secretion|amino acid transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-serine transmembrane transporter activity|neutral amino acid transport|L-serine transport|cerebral cortex development|axon|dendrite|glycine betaine transport|alanine transport|positive regulation of RNA splicing|cellular response to amino acid starvation|sarcolemma|neuronal cell body|cellular response to mechanical stimulus|regulation of cellular response to stress|transport across blood-brain barrier|cellular response to arsenite(3-) "hsa04724,hsa04727,hsa04974" Glutamatergic synapse|GABAergic synapse|Protein digestion and absorption SLC38A4 7.030462899 9.134603715 4.926322083 0.539303317 -0.890831188 0.625563046 1 0.113418841 0.06380199 55089 solute carrier family 38 member 4 "GO:0003333,GO:0005515,GO:0005886,GO:0005887,GO:0006814,GO:0006865,GO:0015171,GO:0015293" amino acid transmembrane transport|protein binding|plasma membrane|integral component of plasma membrane|sodium ion transport|amino acid transport|amino acid transmembrane transporter activity|symporter activity SLC38A5 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.101238679 0.025627604 92745 solute carrier family 38 member 5 "GO:0003333,GO:0005290,GO:0005886,GO:0005887,GO:0006865,GO:0006867,GO:0006868,GO:0015171,GO:0015182,GO:0015186,GO:0015187,GO:0015194,GO:0015816,GO:0015825,GO:0022858,GO:0022889,GO:0032329,GO:0089709,GO:0150104,GO:1903713,GO:1904557" amino acid transmembrane transport|L-histidine transmembrane transporter activity|plasma membrane|integral component of plasma membrane|amino acid transport|asparagine transport|glutamine transport|amino acid transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|glycine transmembrane transporter activity|L-serine transmembrane transporter activity|glycine transport|L-serine transport|alanine transmembrane transporter activity|serine transmembrane transporter activity|serine transport|L-histidine transmembrane transport|transport across blood-brain barrier|asparagine transmembrane transport|L-alanine transmembrane transport hsa04727 GABAergic synapse SLC38A6 293.2401273 311.5914823 274.8887722 0.882208879 -0.180807815 0.708709537 1 3.231164895 2.973353025 145389 solute carrier family 38 member 6 "GO:0003333,GO:0005515,GO:0005886,GO:0005887,GO:0006814,GO:0006868,GO:0015171,GO:0015186" amino acid transmembrane transport|protein binding|plasma membrane|integral component of plasma membrane|sodium ion transport|glutamine transport|amino acid transmembrane transporter activity|L-glutamine transmembrane transporter activity SLC38A7 602.8437594 596.7941094 608.8934094 1.020273826 0.028956402 0.945378143 1 7.008002847 7.458078407 55238 solute carrier family 38 member 7 "GO:0003333,GO:0005290,GO:0005313,GO:0005515,GO:0006814,GO:0006867,GO:0006868,GO:0015171,GO:0015179,GO:0015180,GO:0015182,GO:0015183,GO:0015186,GO:0015190,GO:0015191,GO:0015194,GO:0015803,GO:0015808,GO:0015813,GO:0015821,GO:0015825,GO:0016021,GO:0030424,GO:0043025,GO:0070778,GO:0089709" amino acid transmembrane transport|L-histidine transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding|sodium ion transport|asparagine transport|glutamine transport|amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-aspartate transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-leucine transmembrane transporter activity|L-methionine transmembrane transporter activity|L-serine transmembrane transporter activity|branched-chain amino acid transport|L-alanine transport|L-glutamate transmembrane transport|methionine transport|L-serine transport|integral component of membrane|axon|neuronal cell body|L-aspartate transmembrane transport|L-histidine transmembrane transport SLC38A9 555.9952029 458.7600977 653.2303082 1.423903935 0.509851816 0.200489573 1 6.861955269 10.19165004 153129 solute carrier family 38 member 9 "GO:0003333,GO:0005515,GO:0005764,GO:0005765,GO:0005770,GO:0007050,GO:0015171,GO:0015190,GO:0015803,GO:0015804,GO:0016241,GO:0032008,GO:0046872,GO:0061459,GO:0071230,GO:0071986,GO:1903400,GO:1905103" amino acid transmembrane transport|protein binding|lysosome|lysosomal membrane|late endosome|cell cycle arrest|amino acid transmembrane transporter activity|L-leucine transmembrane transporter activity|branched-chain amino acid transport|neutral amino acid transport|regulation of macroautophagy|positive regulation of TOR signaling|metal ion binding|L-arginine transmembrane transporter activity|cellular response to amino acid stimulus|Ragulator complex|L-arginine transmembrane transport|integral component of lysosomal membrane hsa04150 mTOR signaling pathway SLC39A1 5533.17793 5417.834959 5648.5209 1.04257899 0.060156692 0.852593464 1 90.79888409 98.74279353 27173 solute carrier family 39 member 1 "GO:0001701,GO:0005102,GO:0005385,GO:0005515,GO:0005789,GO:0005886,GO:0006812,GO:0016020,GO:0016021,GO:0022890,GO:0048701,GO:0060173,GO:0071577" in utero embryonic development|signaling receptor binding|zinc ion transmembrane transporter activity|protein binding|endoplasmic reticulum membrane|plasma membrane|cation transport|membrane|integral component of membrane|inorganic cation transmembrane transporter activity|embryonic cranial skeleton morphogenesis|limb development|zinc ion transmembrane transport SLC39A10 881.69487 1069.763591 693.6261492 0.648391995 -0.625061814 0.083349789 1 4.908475446 3.319710387 57181 solute carrier family 39 member 10 "GO:0002903,GO:0005385,GO:0005887,GO:0006882,GO:0030890,GO:0050861,GO:0071578,GO:1903615" negative regulation of B cell apoptotic process|zinc ion transmembrane transporter activity|integral component of plasma membrane|cellular zinc ion homeostasis|positive regulation of B cell proliferation|positive regulation of B cell receptor signaling pathway|zinc ion import across plasma membrane|positive regulation of protein tyrosine phosphatase activity SLC39A11 203.2153642 219.2304892 187.2002391 0.853896919 -0.227866175 0.676085812 1 1.30534339 1.162642382 201266 solute carrier family 39 member 11 "GO:0005385,GO:0005634,GO:0005737,GO:0005794,GO:0005886,GO:0016020,GO:0016021,GO:0071577" zinc ion transmembrane transporter activity|nucleus|cytoplasm|Golgi apparatus|plasma membrane|membrane|integral component of membrane|zinc ion transmembrane transport SLC39A13 1766.345779 1769.068253 1763.623306 0.996922138 -0.004447263 0.991073405 1 30.72601718 31.95092525 91252 solute carrier family 39 member 13 "GO:0005385,GO:0005515,GO:0005783,GO:0005794,GO:0006882,GO:0010043,GO:0016021,GO:0030173,GO:0042803,GO:0048471,GO:0061448,GO:0071577" zinc ion transmembrane transporter activity|protein binding|endoplasmic reticulum|Golgi apparatus|cellular zinc ion homeostasis|response to zinc ion|integral component of membrane|integral component of Golgi membrane|protein homodimerization activity|perinuclear region of cytoplasm|connective tissue development|zinc ion transmembrane transport SLC39A14 5402.604416 5921.253119 4883.955713 0.824817925 -0.277852409 0.388861166 1 49.51958084 42.60405928 23516 solute carrier family 39 member 14 "GO:0002062,GO:0005381,GO:0005384,GO:0005385,GO:0005765,GO:0005886,GO:0005887,GO:0006094,GO:0006882,GO:0008286,GO:0010817,GO:0015086,GO:0015093,GO:0015296,GO:0015698,GO:0016021,GO:0016323,GO:0016324,GO:0031901,GO:0031902,GO:0032869,GO:0033212,GO:0034755,GO:0045745,GO:0051344,GO:0055071,GO:0070574,GO:0071333,GO:0071421,GO:0071577,GO:0071578,GO:0098739" chondrocyte differentiation|iron ion transmembrane transporter activity|manganese ion transmembrane transporter activity|zinc ion transmembrane transporter activity|lysosomal membrane|plasma membrane|integral component of plasma membrane|gluconeogenesis|cellular zinc ion homeostasis|insulin receptor signaling pathway|regulation of hormone levels|cadmium ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|anion:cation symporter activity|inorganic anion transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|early endosome membrane|late endosome membrane|cellular response to insulin stimulus|iron import into cell|iron ion transmembrane transport|positive regulation of G protein-coupled receptor signaling pathway|negative regulation of cyclic-nucleotide phosphodiesterase activity|manganese ion homeostasis|cadmium ion transmembrane transport|cellular response to glucose stimulus|manganese ion transmembrane transport|zinc ion transmembrane transport|zinc ion import across plasma membrane|import across plasma membrane hsa04216 Ferroptosis SLC39A3 577.11084 555.1809147 599.0407653 1.079001006 0.109696209 0.784315268 1 7.122075676 8.015753681 29985 solute carrier family 39 member 3 "GO:0005385,GO:0005886,GO:0016020,GO:0016021,GO:0071577" zinc ion transmembrane transporter activity|plasma membrane|membrane|integral component of membrane|zinc ion transmembrane transport SLC39A4 393.5062463 396.8477836 390.164709 0.983159602 -0.024502458 0.961479798 1 8.042793216 8.247965918 55630 solute carrier family 39 member 4 "GO:0005385,GO:0005886,GO:0005887,GO:0006882,GO:0016324,GO:0031410,GO:0034224,GO:0055038,GO:0071578" zinc ion transmembrane transporter activity|plasma membrane|integral component of plasma membrane|cellular zinc ion homeostasis|apical plasma membrane|cytoplasmic vesicle|cellular response to zinc ion starvation|recycling endosome membrane|zinc ion import across plasma membrane hsa04978 Mineral absorption SLC39A6 2928.461699 2913.938585 2942.984812 1.00996803 0.014309626 0.965286932 1 30.42273956 32.04954556 25800 solute carrier family 39 member 6 "GO:0005385,GO:0005783,GO:0005886,GO:0005887,GO:0006882,GO:0009986,GO:0031258,GO:0071577,GO:0071578" zinc ion transmembrane transporter activity|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cellular zinc ion homeostasis|cell surface|lamellipodium membrane|zinc ion transmembrane transport|zinc ion import across plasma membrane SLC39A7 2906.409048 3326.010708 2486.807387 0.747684721 -0.419498044 0.187737717 1 91.44989626 71.32103757 7922 solute carrier family 39 member 7 "GO:0005385,GO:0005515,GO:0005654,GO:0005783,GO:0005789,GO:0005794,GO:0006882,GO:0016020,GO:0016021,GO:0071577" zinc ion transmembrane transporter activity|protein binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cellular zinc ion homeostasis|membrane|integral component of membrane|zinc ion transmembrane transport SLC39A8 387.6716103 368.4290165 406.914204 1.104457537 0.143337952 0.747337428 1 2.904674649 3.346281306 64116 solute carrier family 39 member 8 "GO:0005381,GO:0005384,GO:0005385,GO:0005765,GO:0005886,GO:0005887,GO:0006351,GO:0006355,GO:0006487,GO:0006525,GO:0006824,GO:0006829,GO:0006876,GO:0006882,GO:0015086,GO:0015087,GO:0015106,GO:0015296,GO:0015698,GO:0015701,GO:0016323,GO:0016324,GO:0030026,GO:0030198,GO:0031090,GO:0042391,GO:0061757,GO:0070574,GO:0071421,GO:0071577,GO:0071578,GO:0097079,GO:0097080,GO:0098711,GO:0140412,GO:1990079,GO:1990540" "iron ion transmembrane transporter activity|manganese ion transmembrane transporter activity|zinc ion transmembrane transporter activity|lysosomal membrane|plasma membrane|integral component of plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|protein N-linked glycosylation|arginine metabolic process|cobalt ion transport|zinc ion transport|cellular cadmium ion homeostasis|cellular zinc ion homeostasis|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|bicarbonate transmembrane transporter activity|anion:cation symporter activity|inorganic anion transport|bicarbonate transport|basolateral plasma membrane|apical plasma membrane|cellular manganese ion homeostasis|extracellular matrix organization|organelle membrane|regulation of membrane potential|leukocyte adhesion to arterial endothelial cell|cadmium ion transmembrane transport|manganese ion transmembrane transport|zinc ion transmembrane transport|zinc ion import across plasma membrane|selenite:proton symporter activity|plasma membrane selenite transport|iron ion import across plasma membrane|zinc:bicarbonate symporter activity|cartilage homeostasis|mitochondrial manganese ion transmembrane transport" hsa04216 Ferroptosis SLC39A9 1545.287776 1407.743928 1682.831623 1.195410323 0.257505906 0.435954203 1 12.69086218 15.82428366 55334 solute carrier family 39 member 9 "GO:0005515,GO:0006829,GO:0016021,GO:0046873,GO:0055085" protein binding|zinc ion transport|integral component of membrane|metal ion transmembrane transporter activity|transmembrane transport SLC3A2 2332.333673 2708.91748 1955.749867 0.72196731 -0.469994579 0.141822579 1 56.22832535 42.34368134 6520 solute carrier family 3 member 2 "GO:0003723,GO:0003725,GO:0003824,GO:0005432,GO:0005515,GO:0005654,GO:0005765,GO:0005886,GO:0005975,GO:0006816,GO:0006865,GO:0009925,GO:0009986,GO:0015173,GO:0015175,GO:0015180,GO:0015190,GO:0015823,GO:0015827,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0030054,GO:0035725,GO:0042470,GO:0043330,GO:0045296,GO:0050900,GO:0070062,GO:0098713,GO:1902475,GO:1903801,GO:1904273,GO:1990184" RNA binding|double-stranded RNA binding|catalytic activity|calcium:sodium antiporter activity|protein binding|nucleoplasm|lysosomal membrane|plasma membrane|carbohydrate metabolic process|calcium ion transport|amino acid transport|basal plasma membrane|cell surface|aromatic amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-leucine transmembrane transporter activity|phenylalanine transport|tryptophan transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cell junction|sodium ion transmembrane transport|melanosome|response to exogenous dsRNA|cadherin binding|leukocyte migration|extracellular exosome|leucine import across plasma membrane|L-alpha-amino acid transmembrane transport|L-leucine import across plasma membrane|L-alanine import across plasma membrane|amino acid transport complex "hsa04150,hsa04216,hsa04974" mTOR signaling pathway|Ferroptosis|Protein digestion and absorption SLC40A1 49.46834009 47.70293051 51.23374966 1.074016818 0.103016585 0.927999878 1 0.670362138 0.750994038 30061 solute carrier family 40 member 1 "GO:0005381,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006879,GO:0015093,GO:0016021,GO:0016323,GO:0017046,GO:0034755,GO:0055072,GO:0060586,GO:0072511,GO:1903988" iron ion transmembrane transporter activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|integral component of plasma membrane|cellular iron ion homeostasis|ferrous iron transmembrane transporter activity|integral component of membrane|basolateral plasma membrane|peptide hormone binding|iron ion transmembrane transport|iron ion homeostasis|multicellular organismal iron ion homeostasis|divalent inorganic cation transport|iron ion export across plasma membrane "hsa04216,hsa04978" Ferroptosis|Mineral absorption SLC41A1 1888.096204 1639.153889 2137.038519 1.303744898 0.382661607 0.237279059 1 16.33556904 22.21482105 254428 solute carrier family 41 member 1 "GO:0005515,GO:0005886,GO:0010961,GO:0015095,GO:0015693,GO:0016021,GO:0016323,GO:0022857,GO:0032991,GO:0035725,GO:0061768,GO:0070838,GO:0071286,GO:0072509,GO:1903830" protein binding|plasma membrane|cellular magnesium ion homeostasis|magnesium ion transmembrane transporter activity|magnesium ion transport|integral component of membrane|basolateral plasma membrane|transmembrane transporter activity|protein-containing complex|sodium ion transmembrane transport|magnesium:sodium antiporter activity|divalent metal ion transport|cellular response to magnesium ion|divalent inorganic cation transmembrane transporter activity|magnesium ion transmembrane transport SLC41A2 407.7992613 498.3433805 317.2551421 0.636619557 -0.651496617 0.131242804 1 2.278329497 1.512907719 84102 solute carrier family 41 member 2 "GO:0005515,GO:0005886,GO:0016021,GO:0070838,GO:0072509,GO:0098655" protein binding|plasma membrane|integral component of membrane|divalent metal ion transport|divalent inorganic cation transmembrane transporter activity|cation transmembrane transport SLC41A3 481.4026202 411.0571672 551.7480733 1.342266033 0.424670638 0.303696291 1 9.008479185 12.61264028 54946 solute carrier family 41 member 3 "GO:0005515,GO:0005886,GO:0008324,GO:0016021,GO:0098655" protein binding|plasma membrane|cation transmembrane transporter activity|integral component of membrane|cation transmembrane transport SLC43A1 284.6926736 232.4249168 336.9604305 1.449760358 0.535814446 0.26557455 1 3.466284478 5.241750585 8501 solute carrier family 43 member 1 "GO:0005515,GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015175,GO:0015179,GO:0015804,GO:0015807,GO:0051956,GO:0060358,GO:1902475" protein binding|plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|neutral amino acid transport|L-amino acid transport|negative regulation of amino acid transport|negative regulation of leucine import|L-alpha-amino acid transmembrane transport SLC43A2 430.6006358 608.973581 252.2276906 0.414184947 -1.271652972 0.003098817 0.190915322 3.352430821 1.448338468 124935 solute carrier family 43 member 2 "GO:0005515,GO:0005886,GO:0006865,GO:0015171,GO:0015175,GO:0015179,GO:0015804,GO:0015807,GO:0016021,GO:0051956,GO:0060358,GO:1902475" protein binding|plasma membrane|amino acid transport|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|neutral amino acid transport|L-amino acid transport|integral component of membrane|negative regulation of amino acid transport|negative regulation of leucine import|L-alpha-amino acid transmembrane transport SLC43A3 463.9472089 463.8348775 464.0595402 1.000484359 0.000698613 1 1 8.292128569 8.653509215 29015 solute carrier family 43 member 3 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021,GO:0022857,GO:0055085" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC44A1 1955.408421 1997.433346 1913.383497 0.957921075 -0.062021301 0.848954014 1 8.073659413 8.067074774 23446 solute carrier family 44 member 1 "GO:0005654,GO:0005739,GO:0005741,GO:0005829,GO:0005886,GO:0006656,GO:0015220,GO:0015871,GO:0016020,GO:0016021,GO:0022857,GO:0042426,GO:0055085,GO:0070062,GO:0150104" nucleoplasm|mitochondrion|mitochondrial outer membrane|cytosol|plasma membrane|phosphatidylcholine biosynthetic process|choline transmembrane transporter activity|choline transport|membrane|integral component of membrane|transmembrane transporter activity|choline catabolic process|transmembrane transport|extracellular exosome|transport across blood-brain barrier hsa05231 Choline metabolism in cancer SLC44A2 3292.283328 3032.688434 3551.878222 1.171197866 0.22798483 0.473641264 1 42.59427911 52.03522952 57153 solute carrier family 44 member 2 "GO:0005739,GO:0005765,GO:0005886,GO:0006656,GO:0015220,GO:0015871,GO:0016020,GO:0016021,GO:0022857,GO:0035579,GO:0043123,GO:0043312,GO:0055085,GO:0070062" mitochondrion|lysosomal membrane|plasma membrane|phosphatidylcholine biosynthetic process|choline transmembrane transporter activity|choline transport|membrane|integral component of membrane|transmembrane transporter activity|specific granule membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|transmembrane transport|extracellular exosome hsa05231 Choline metabolism in cancer SLC44A3 46.36408908 37.55337083 55.17480733 1.469237145 0.555067275 0.531049715 1 0.607456325 0.930942564 126969 solute carrier family 44 member 3 "GO:0005515,GO:0005886,GO:0006656,GO:0016020,GO:0016021,GO:0022857,GO:0055085" protein binding|plasma membrane|phosphatidylcholine biosynthetic process|membrane|integral component of membrane|transmembrane transporter activity|transmembrane transport hsa05231 Choline metabolism in cancer SLC44A5 110.9380025 107.5853326 114.2906723 1.062325779 0.087226259 0.907676551 1 0.622508575 0.689793327 204962 solute carrier family 44 member 5 "GO:0005515,GO:0005886,GO:0006656,GO:0016020,GO:0016021,GO:0022857,GO:0055085" protein binding|plasma membrane|phosphatidylcholine biosynthetic process|membrane|integral component of membrane|transmembrane transporter activity|transmembrane transport hsa05231 Choline metabolism in cancer SLC45A1 105.6378144 115.7049804 95.57064841 0.825985606 -0.275811453 0.686931757 1 2.347776071 2.022763373 50651 solute carrier family 45 member 1 "GO:0008506,GO:0015770,GO:0016020,GO:0016021,GO:1904659" sucrose:proton symporter activity|sucrose transport|membrane|integral component of membrane|glucose transmembrane transport SLC45A3 379.6383156 391.7730038 367.5036274 0.938052453 -0.092259498 0.83916819 1 5.851347847 5.725309514 85414 solute carrier family 45 member 3 "GO:0005886,GO:0008506,GO:0008645,GO:0010907,GO:0015770,GO:0016020,GO:0016021,GO:0045723,GO:0048713,GO:0051119" plasma membrane|sucrose:proton symporter activity|hexose transmembrane transport|positive regulation of glucose metabolic process|sucrose transport|membrane|integral component of membrane|positive regulation of fatty acid biosynthetic process|regulation of oligodendrocyte differentiation|sugar transmembrane transporter activity "hsa05202,hsa05206" Transcriptional misregulation in cancer|MicroRNAs in cancer SLC45A4 83.3681662 75.10674166 91.62959074 1.219991558 0.286871164 0.700496044 1 0.274411449 0.349200601 57210 solute carrier family 45 member 4 "GO:0008506,GO:0015770,GO:0016020,GO:0016021" sucrose:proton symporter activity|sucrose transport|membrane|integral component of membrane SLC46A1 592.0340585 800.800259 383.267858 0.478606062 -1.063089426 0.007140222 0.341973728 6.084264637 3.037401617 113235 solute carrier family 46 member 1 "GO:0005542,GO:0005737,GO:0005886,GO:0006879,GO:0008517,GO:0009986,GO:0015078,GO:0015232,GO:0015350,GO:0015884,GO:0015886,GO:0016021,GO:0016323,GO:0016324,GO:0031526,GO:0046655,GO:0051958,GO:0098829,GO:1902600,GO:1904447" folic acid binding|cytoplasm|plasma membrane|cellular iron ion homeostasis|folic acid transmembrane transporter activity|cell surface|proton transmembrane transporter activity|heme transmembrane transporter activity|methotrexate transmembrane transporter activity|folic acid transport|heme transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|brush border membrane|folic acid metabolic process|methotrexate transport|intestinal folate absorption|proton transmembrane transport|folate import across plasma membrane "hsa01523,hsa04977,hsa04978" Antifolate resistance|Vitamin digestion and absorption|Mineral absorption SLC48A1 65.43769001 95.40586103 35.469519 0.371775053 -1.427498131 0.069760684 1 0.880942623 0.3416204 55652 solute carrier family 48 member 1 "GO:0005515,GO:0005765,GO:0005886,GO:0010008,GO:0015232,GO:0015886,GO:0016021,GO:0020037" protein binding|lysosomal membrane|plasma membrane|endosome membrane|heme transmembrane transporter activity|heme transport|integral component of membrane|heme binding SLC49A3 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.087471252 0.039364465 84179 solute carrier family 49 member 3 "GO:0016021,GO:0022857,GO:0055085" integral component of membrane|transmembrane transporter activity|transmembrane transport SLC49A4 376.3586369 335.9504255 416.7668482 1.240560561 0.310992165 0.482590832 1 5.121825374 6.627636288 84925 solute carrier family 49 member 4 "GO:0005765,GO:0016021,GO:0043231" lysosomal membrane|integral component of membrane|intracellular membrane-bounded organelle SLC4A11 405.1930857 421.2067269 389.1794445 0.923963032 -0.114092964 0.796214313 1 3.492572821 3.366014598 83959 solute carrier family 4 member 11 "GO:0005272,GO:0005452,GO:0005886,GO:0006814,GO:0012506,GO:0015106,GO:0015252,GO:0015293,GO:0015301,GO:0015701,GO:0016021,GO:0016323,GO:0016324,GO:0022857,GO:0030003,GO:0035445,GO:0035725,GO:0042044,GO:0046713,GO:0046715,GO:0046983,GO:0050801,GO:0055085,GO:1902600" sodium channel activity|inorganic anion exchanger activity|plasma membrane|sodium ion transport|vesicle membrane|bicarbonate transmembrane transporter activity|proton channel activity|symporter activity|anion:anion antiporter activity|bicarbonate transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|transmembrane transporter activity|cellular cation homeostasis|borate transmembrane transport|sodium ion transmembrane transport|fluid transport|borate transport|active borate transmembrane transporter activity|protein dimerization activity|ion homeostasis|transmembrane transport|proton transmembrane transport SLC4A1AP 502.4764415 470.9395693 534.0133138 1.133931716 0.181333765 0.659404157 1 8.030783775 9.498625498 22950 solute carrier family 4 member 1 adaptor protein "GO:0003729,GO:0005515,GO:0005654,GO:0005737,GO:0005886,GO:0043231" mRNA binding|protein binding|nucleoplasm|cytoplasm|plasma membrane|intracellular membrane-bounded organelle SLC4A2 4577.998221 4813.936158 4342.060284 0.901977123 -0.148837253 0.642010369 1 42.22530029 39.72685624 6522 solute carrier family 4 member 2 "GO:0005452,GO:0005886,GO:0005925,GO:0006820,GO:0007283,GO:0008509,GO:0015301,GO:0015698,GO:0015701,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0019899,GO:0022857,GO:0048565,GO:0050801,GO:0051453,GO:0055085,GO:0098656" inorganic anion exchanger activity|plasma membrane|focal adhesion|anion transport|spermatogenesis|anion transmembrane transporter activity|anion:anion antiporter activity|inorganic anion transport|bicarbonate transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|enzyme binding|transmembrane transporter activity|digestive tract development|ion homeostasis|regulation of intracellular pH|transmembrane transport|anion transmembrane transport "hsa04970,hsa04971,hsa04972,hsa04976" Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion SLC4A3 444.6536429 357.2645009 532.0427849 1.489212568 0.574549697 0.172835931 1 3.751645576 5.827662949 6508 solute carrier family 4 member 3 "GO:0005452,GO:0005515,GO:0005886,GO:0005887,GO:0009897,GO:0015106,GO:0015301,GO:0015698,GO:0015701,GO:0016020,GO:0022857,GO:0050801,GO:0051453,GO:0055085,GO:0061337,GO:0086001,GO:0098656,GO:0150104" inorganic anion exchanger activity|protein binding|plasma membrane|integral component of plasma membrane|external side of plasma membrane|bicarbonate transmembrane transporter activity|anion:anion antiporter activity|inorganic anion transport|bicarbonate transport|membrane|transmembrane transporter activity|ion homeostasis|regulation of intracellular pH|transmembrane transport|cardiac conduction|cardiac muscle cell action potential|anion transmembrane transport|transport across blood-brain barrier SLC4A4 102.3878272 61.91231407 142.8633404 2.307510914 1.206337471 0.074943509 1 0.271131889 0.652589817 8671 solute carrier family 4 member 4 "GO:0005452,GO:0005515,GO:0005886,GO:0005887,GO:0006814,GO:0008510,GO:0009986,GO:0015293,GO:0015698,GO:0015701,GO:0016020,GO:0016323,GO:0022857,GO:0035725,GO:0036376,GO:0042391,GO:0042802,GO:0044214,GO:0045821,GO:0050801,GO:0051453,GO:0055085,GO:0070062,GO:0098656,GO:0150104" inorganic anion exchanger activity|protein binding|plasma membrane|integral component of plasma membrane|sodium ion transport|sodium:bicarbonate symporter activity|cell surface|symporter activity|inorganic anion transport|bicarbonate transport|membrane|basolateral plasma membrane|transmembrane transporter activity|sodium ion transmembrane transport|sodium ion export across plasma membrane|regulation of membrane potential|identical protein binding|spanning component of plasma membrane|positive regulation of glycolytic process|ion homeostasis|regulation of intracellular pH|transmembrane transport|extracellular exosome|anion transmembrane transport|transport across blood-brain barrier "hsa04964,hsa04972,hsa04976" Proximal tubule bicarbonate reclamation|Pancreatic secretion|Bile secretion SLC4A5 20.46514451 18.26920743 22.66108158 1.240397629 0.310802673 0.814971331 1 0.142130708 0.183892821 57835 solute carrier family 4 member 5 "GO:0002064,GO:0003014,GO:0003073,GO:0005452,GO:0005886,GO:0008510,GO:0010468,GO:0015301,GO:0015698,GO:0015701,GO:0016021,GO:0016324,GO:0022857,GO:0033326,GO:0035725,GO:0048311,GO:0050801,GO:0051453,GO:0055085,GO:0060041,GO:0098656" epithelial cell development|renal system process|regulation of systemic arterial blood pressure|inorganic anion exchanger activity|plasma membrane|sodium:bicarbonate symporter activity|regulation of gene expression|anion:anion antiporter activity|inorganic anion transport|bicarbonate transport|integral component of membrane|apical plasma membrane|transmembrane transporter activity|cerebrospinal fluid secretion|sodium ion transmembrane transport|mitochondrion distribution|ion homeostasis|regulation of intracellular pH|transmembrane transport|retina development in camera-type eye|anion transmembrane transport hsa04976 Bile secretion SLC4A7 3112.162294 2809.39812 3414.926468 1.215536681 0.28159343 0.376128051 1 16.68066868 21.14937097 9497 solute carrier family 4 member 7 "GO:0005452,GO:0005515,GO:0005886,GO:0008510,GO:0015698,GO:0015701,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0022857,GO:0031410,GO:0032420,GO:0035725,GO:0045202,GO:0050801,GO:0051453,GO:0055085,GO:0060117,GO:0098656" inorganic anion exchanger activity|protein binding|plasma membrane|sodium:bicarbonate symporter activity|inorganic anion transport|bicarbonate transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|transmembrane transporter activity|cytoplasmic vesicle|stereocilium|sodium ion transmembrane transport|synapse|ion homeostasis|regulation of intracellular pH|transmembrane transport|auditory receptor cell development|anion transmembrane transport SLC4A8 192.961884 191.826678 194.0970901 1.011835747 0.016975114 0.985888539 1 0.68834806 0.726497361 9498 solute carrier family 4 member 8 "GO:0005452,GO:0005886,GO:0008021,GO:0008510,GO:0015081,GO:0015106,GO:0015108,GO:0015301,GO:0015701,GO:0016020,GO:0016021,GO:0022857,GO:0030425,GO:0032279,GO:0032280,GO:0032809,GO:0035725,GO:0042391,GO:0042734,GO:0043005,GO:0043195,GO:0043679,GO:0050801,GO:0050804,GO:0051453,GO:0055085,GO:0097386,GO:0097457,GO:0098793,GO:0098978,GO:0150104,GO:1902476,GO:2000302" inorganic anion exchanger activity|plasma membrane|synaptic vesicle|sodium:bicarbonate symporter activity|sodium ion transmembrane transporter activity|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|membrane|integral component of membrane|transmembrane transporter activity|dendrite|asymmetric synapse|symmetric synapse|neuronal cell body membrane|sodium ion transmembrane transport|regulation of membrane potential|presynaptic membrane|neuron projection|terminal bouton|axon terminus|ion homeostasis|modulation of chemical synaptic transmission|regulation of intracellular pH|transmembrane transport|glial cell projection|hippocampal mossy fiber|presynapse|glutamatergic synapse|transport across blood-brain barrier|chloride transmembrane transport|positive regulation of synaptic vesicle exocytosis SLC50A1 835.29713 895.1911641 775.4030958 0.866187164 -0.207249301 0.570540049 1 28.69511039 25.92600338 55974 solute carrier family 50 member 1 "GO:0000139,GO:0005515,GO:0005794,GO:0005886,GO:0008643,GO:0008645,GO:0012505,GO:0016021,GO:0042946,GO:0042947,GO:0051119" Golgi membrane|protein binding|Golgi apparatus|plasma membrane|carbohydrate transport|hexose transmembrane transport|endomembrane system|integral component of membrane|glucoside transport|glucoside transmembrane transporter activity|sugar transmembrane transporter activity SLC52A1 12.98658673 12.17947162 13.79370183 1.132536966 0.17955814 0.952676516 1 0.301784379 0.356504546 55065 solute carrier family 52 member 1 "GO:0001618,GO:0005515,GO:0005886,GO:0005887,GO:0006771,GO:0032217,GO:0032218,GO:0046718" virus receptor activity|protein binding|plasma membrane|integral component of plasma membrane|riboflavin metabolic process|riboflavin transmembrane transporter activity|riboflavin transport|viral entry into host cell SLC52A2 2345.431354 2088.779383 2602.083324 1.245743493 0.317007038 0.321382991 1 45.81607058 59.53363441 79581 solute carrier family 52 member 2 "GO:0001618,GO:0005515,GO:0005886,GO:0005887,GO:0006771,GO:0032217,GO:0032218,GO:0046718,GO:0062124" virus receptor activity|protein binding|plasma membrane|integral component of plasma membrane|riboflavin metabolic process|riboflavin transmembrane transporter activity|riboflavin transport|viral entry into host cell|4-hydroxybutyrate receptor activity SLC52A3 5.433800067 1.014955968 9.852644165 9.707459705 3.279093814 0.119754137 1 0.019010333 0.19249136 113278 solute carrier family 52 member 3 "GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006771,GO:0007605,GO:0016324,GO:0031965,GO:0032217,GO:0032218,GO:0034605" protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|riboflavin metabolic process|sensory perception of sound|apical plasma membrane|nuclear membrane|riboflavin transmembrane transporter activity|riboflavin transport|cellular response to heat hsa04977 Vitamin digestion and absorption SLC5A10 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.063513928 0.042874517 125206 solute carrier family 5 member 10 "GO:0005412,GO:0005886,GO:0006814,GO:0008645,GO:0015370,GO:0016021,GO:0035725,GO:0070062,GO:1904659" glucose:sodium symporter activity|plasma membrane|sodium ion transport|hexose transmembrane transport|solute:sodium symporter activity|integral component of membrane|sodium ion transmembrane transport|extracellular exosome|glucose transmembrane transport SLC5A12 5.941278051 2.029911937 9.852644165 4.853729853 2.279093814 0.221443742 1 0.013940051 0.070575815 159963 solute carrier family 5 member 12 "GO:0005343,GO:0005654,GO:0005886,GO:0006811,GO:0006814,GO:0015129,GO:0015293,GO:0016021,GO:0016324,GO:0035873,GO:0070062" organic acid:sodium symporter activity|nucleoplasm|plasma membrane|ion transport|sodium ion transport|lactate transmembrane transporter activity|symporter activity|integral component of membrane|apical plasma membrane|lactate transmembrane transport|extracellular exosome SLC5A2 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.036009765 0.072924222 6524 solute carrier family 5 member 2 "GO:0000017,GO:0005362,GO:0005412,GO:0005886,GO:0005975,GO:0006814,GO:0008645,GO:0015151,GO:0016021,GO:0055056,GO:0070062,GO:0098708,GO:0098719" alpha-glucoside transport|low-affinity glucose:sodium symporter activity|glucose:sodium symporter activity|plasma membrane|carbohydrate metabolic process|sodium ion transport|hexose transmembrane transport|alpha-glucoside transmembrane transporter activity|integral component of membrane|D-glucose transmembrane transporter activity|extracellular exosome|glucose import across plasma membrane|sodium ion import across plasma membrane SLC5A3 2008.446429 2390.221306 1626.671552 0.680552695 -0.555221221 0.085261083 1 10.4665638 7.429880233 6526 solute carrier family 5 member 3 "GO:0005365,GO:0005367,GO:0005412,GO:0005886,GO:0005887,GO:0006020,GO:0006814,GO:0007422,GO:0015146,GO:0015150,GO:0015166,GO:0015459,GO:0015750,GO:0015756,GO:0015791,GO:0015798,GO:0016021,GO:0043085,GO:0043576,GO:0044325,GO:0048471,GO:0150104,GO:1903428,GO:1904659,GO:1904679,GO:1905477" myo-inositol transmembrane transporter activity|myo-inositol:sodium symporter activity|glucose:sodium symporter activity|plasma membrane|integral component of plasma membrane|inositol metabolic process|sodium ion transport|peripheral nervous system development|pentose transmembrane transporter activity|fucose transmembrane transporter activity|polyol transmembrane transporter activity|potassium channel regulator activity|pentose transmembrane transport|fucose transmembrane transport|polyol transport|myo-inositol transport|integral component of membrane|positive regulation of catalytic activity|regulation of respiratory gaseous exchange|ion channel binding|perinuclear region of cytoplasm|transport across blood-brain barrier|positive regulation of reactive oxygen species biosynthetic process|glucose transmembrane transport|myo-inositol import across plasma membrane|positive regulation of protein localization to membrane SLC5A6 551.7233328 671.9008511 431.5458144 0.642276035 -0.638734628 0.109600229 1 9.85502687 6.602303129 8884 solute carrier family 5 member 6 "GO:0005886,GO:0005887,GO:0006768,GO:0006814,GO:0008523,GO:0009925,GO:0012506,GO:0015225,GO:0015233,GO:0015293,GO:0015878,GO:0015887,GO:0015939,GO:0016020,GO:0016323,GO:0016324,GO:0031526,GO:0055085,GO:0150104,GO:1905135" plasma membrane|integral component of plasma membrane|biotin metabolic process|sodium ion transport|sodium-dependent multivitamin transmembrane transporter activity|basal plasma membrane|vesicle membrane|biotin transmembrane transporter activity|pantothenate transmembrane transporter activity|symporter activity|biotin transport|pantothenate transmembrane transport|pantothenate metabolic process|membrane|basolateral plasma membrane|apical plasma membrane|brush border membrane|transmembrane transport|transport across blood-brain barrier|biotin import across plasma membrane hsa04977 Vitamin digestion and absorption SLC66A1 419.7763353 441.5058462 398.0468243 0.901566373 -0.149494389 0.730457399 1 3.641216996 3.424208458 54896 solute carrier family 66 member 1 "GO:0005765,GO:0015174,GO:0015181,GO:0015189,GO:0015809,GO:0015819,GO:0016021,GO:0031301,GO:0043231,GO:0055085,GO:0080144,GO:1903401,GO:1903826" lysosomal membrane|basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity|L-lysine transmembrane transporter activity|arginine transport|lysine transport|integral component of membrane|integral component of organelle membrane|intracellular membrane-bounded organelle|transmembrane transport|amino acid homeostasis|L-lysine transmembrane transport|arginine transmembrane transport SLC66A2 999.0655449 1010.896145 987.2349454 0.976593838 -0.03416942 0.925640224 1 11.93990753 12.16272459 80148 solute carrier family 66 member 2 "GO:0005515,GO:0005768,GO:0005802,GO:0005829,GO:0016021,GO:0042147,GO:0045332" "protein binding|endosome|trans-Golgi network|cytosol|integral component of membrane|retrograde transport, endosome to Golgi|phospholipid translocation" SLC66A3 120.968796 119.7648043 122.1727877 1.020105935 0.02871898 0.978490814 1 3.532711026 3.758973966 130814 solute carrier family 66 member 3 GO:0016021 integral component of membrane SLC6A16 19.58380052 25.37389921 13.79370183 0.543617743 -0.879335549 0.443480744 1 0.346948834 0.19673199 28968 solute carrier family 6 member 16 "GO:0005326,GO:0005886,GO:0006836,GO:0015293,GO:0016021,GO:0035725" neurotransmitter transmembrane transporter activity|plasma membrane|neurotransmitter transport|symporter activity|integral component of membrane|sodium ion transmembrane transport SLC6A20 9.404549285 3.044867905 15.76423066 5.177311843 2.372203218 0.119612446 1 0.024784927 0.133846773 54716 solute carrier family 6 member 20 "GO:0005298,GO:0005515,GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015175,GO:0015188,GO:0015193,GO:0015199,GO:0015816,GO:0015824,GO:0015838,GO:0016324,GO:0035725,GO:0089718,GO:0150104,GO:1903806,GO:1904271,GO:1905647" proline:sodium symporter activity|protein binding|plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-proline transmembrane transporter activity|amino-acid betaine transmembrane transporter activity|glycine transport|proline transport|amino-acid betaine transport|apical plasma membrane|sodium ion transmembrane transport|amino acid import across plasma membrane|transport across blood-brain barrier|L-isoleucine import across plasma membrane|L-proline import across plasma membrane|proline import across plasma membrane SLC6A6 1337.069139 1216.932206 1457.206072 1.197442277 0.259956112 0.440330381 1 9.000193218 11.24145044 6533 solute carrier family 6 member 6 "GO:0005368,GO:0005369,GO:0005886,GO:0005887,GO:0006836,GO:0006865,GO:0010940,GO:0015171,GO:0015185,GO:0015734,GO:0016021,GO:0016323,GO:0016324,GO:0022858,GO:0030425,GO:0031528,GO:0032328,GO:0035725,GO:0043025,GO:0045597,GO:0051939,GO:0071705,GO:0089718,GO:0098739,GO:0098797,GO:0150104" taurine transmembrane transporter activity|taurine:sodium symporter activity|plasma membrane|integral component of plasma membrane|neurotransmitter transport|amino acid transport|positive regulation of necrotic cell death|amino acid transmembrane transporter activity|gamma-aminobutyric acid transmembrane transporter activity|taurine transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|alanine transmembrane transporter activity|dendrite|microvillus membrane|alanine transport|sodium ion transmembrane transport|neuronal cell body|positive regulation of cell differentiation|gamma-aminobutyric acid import|nitrogen compound transport|amino acid import across plasma membrane|import across plasma membrane|plasma membrane protein complex|transport across blood-brain barrier SLC6A8 1913.85288 2490.701946 1337.003813 0.536797996 -0.897548809 0.00579286 0.296288375 31.34043899 17.54817234 6535 solute carrier family 6 member 8 "GO:0003674,GO:0005308,GO:0005309,GO:0005886,GO:0005887,GO:0006600,GO:0006836,GO:0006936,GO:0015881,GO:0016021,GO:0035725,GO:0071705" molecular_function|creatine transmembrane transporter activity|creatine:sodium symporter activity|plasma membrane|integral component of plasma membrane|creatine metabolic process|neurotransmitter transport|muscle contraction|creatine transmembrane transport|integral component of membrane|sodium ion transmembrane transport|nitrogen compound transport SLC6A9 429.5062539 298.3970547 560.615453 1.878756657 0.909778216 0.03312253 0.819238635 4.164441482 8.160997148 6536 solute carrier family 6 member 9 "GO:0005768,GO:0005886,GO:0005887,GO:0006836,GO:0009925,GO:0014069,GO:0015187,GO:0015375,GO:0015816,GO:0016020,GO:0016323,GO:0016324,GO:0016328,GO:0030285,GO:0031045,GO:0035725,GO:0046985,GO:0070455,GO:0098686,GO:0098688,GO:0099055,GO:0099056,GO:0150104,GO:1903804,GO:1904256,GO:1904440,GO:1904782" endosome|plasma membrane|integral component of plasma membrane|neurotransmitter transport|basal plasma membrane|postsynaptic density|glycine transmembrane transporter activity|glycine:sodium symporter activity|glycine transport|membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|integral component of synaptic vesicle membrane|dense core granule|sodium ion transmembrane transport|positive regulation of hemoglobin biosynthetic process|positive regulation of heme biosynthetic process|hippocampal mossy fiber to CA3 synapse|parallel fiber to Purkinje cell synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|transport across blood-brain barrier|glycine import across plasma membrane|positive regulation of iron ion transmembrane transporter activity|positive regulation of iron ion import across plasma membrane|negative regulation of NMDA glutamate receptor activity hsa04721 Synaptic vesicle cycle SLC7A1 3055.463569 3008.32949 3102.597648 1.031335716 0.044514029 0.889642401 1 20.54771085 22.10443574 6541 solute carrier family 7 member 1 "GO:0000064,GO:0005290,GO:0005515,GO:0005886,GO:0005887,GO:0006865,GO:0009925,GO:0015171,GO:0015174,GO:0015181,GO:0015189,GO:0015807,GO:0015819,GO:0015822,GO:0016020,GO:0016323,GO:0016324,GO:0032991,GO:0042102,GO:0061459,GO:0089718,GO:0097638,GO:0150104,GO:1903352,GO:1903401,GO:1903810,GO:1903826,GO:1990822" L-ornithine transmembrane transporter activity|L-histidine transmembrane transporter activity|protein binding|plasma membrane|integral component of plasma membrane|amino acid transport|basal plasma membrane|amino acid transmembrane transporter activity|basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity|L-lysine transmembrane transporter activity|L-amino acid transport|lysine transport|ornithine transport|membrane|basolateral plasma membrane|apical plasma membrane|protein-containing complex|positive regulation of T cell proliferation|L-arginine transmembrane transporter activity|amino acid import across plasma membrane|L-arginine import across plasma membrane|transport across blood-brain barrier|L-ornithine transmembrane transport|L-lysine transmembrane transport|L-histidine import across plasma membrane|arginine transmembrane transport|basic amino acid transmembrane transport hsa05206 MicroRNAs in cancer SLC7A11 857.7236468 474.9993932 1240.4479 2.6114726 1.384863567 0.000170503 0.024585069 2.469415271 6.726598913 23657 solute carrier family 7 member 11 "GO:0003333,GO:0005515,GO:0005791,GO:0005856,GO:0005886,GO:0006749,GO:0006865,GO:0008542,GO:0009636,GO:0009986,GO:0014070,GO:0015179,GO:0015327,GO:0016021,GO:0021591,GO:0021756,GO:0030534,GO:0031526,GO:0033029,GO:0034599,GO:0034775,GO:0035094,GO:0042127,GO:0045177,GO:0048021,GO:0048286,GO:0050804,GO:0050807,GO:0050900,GO:0051223,GO:0051775,GO:0060173,GO:0070306,GO:0070527,GO:0090461,GO:0097449,GO:0098712,GO:0140206,GO:1901494,GO:1903204,GO:1903786,GO:1904717,GO:2000211" amino acid transmembrane transport|protein binding|rough endoplasmic reticulum|cytoskeleton|plasma membrane|glutathione metabolic process|amino acid transport|visual learning|response to toxic substance|cell surface|response to organic cyclic compound|L-amino acid transmembrane transporter activity|cystine:glutamate antiporter activity|integral component of membrane|ventricular system development|striatum development|adult behavior|brush border membrane|regulation of neutrophil apoptotic process|cellular response to oxidative stress|glutathione transmembrane transport|response to nicotine|regulation of cell population proliferation|apical part of cell|regulation of melanin biosynthetic process|lung alveolus development|modulation of chemical synaptic transmission|regulation of synapse organization|leukocyte migration|regulation of protein transport|response to redox state|limb development|lens fiber cell differentiation|platelet aggregation|glutamate homeostasis|astrocyte projection|L-glutamate import across plasma membrane|dipeptide import across plasma membrane|regulation of cysteine metabolic process|negative regulation of oxidative stress-induced neuron death|regulation of glutathione biosynthetic process|regulation of AMPA glutamate receptor clustering|regulation of glutamate metabolic process hsa04216 Ferroptosis SLC7A2 390.0172429 528.7920595 251.2424262 0.475125187 -1.073620407 0.014653021 0.53522651 3.29415158 1.632554028 6542 solute carrier family 7 member 2 "GO:0000064,GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015174,GO:0015181,GO:0015189,GO:0030054,GO:0097638,GO:0150104,GO:1903352,GO:1903401" L-ornithine transmembrane transporter activity|plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity|L-lysine transmembrane transporter activity|cell junction|L-arginine import across plasma membrane|transport across blood-brain barrier|L-ornithine transmembrane transport|L-lysine transmembrane transport SLC7A5 5242.036261 7573.601436 2910.471086 0.384291557 -1.379726815 2.52E-05 0.00549578 71.58943536 28.69628716 8140 solute carrier family 7 member 5 "GO:0002720,GO:0003333,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0009925,GO:0010629,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015190,GO:0015196,GO:0015349,GO:0015804,GO:0015823,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0031528,GO:0032729,GO:0032740,GO:0032753,GO:0042605,GO:0042908,GO:0043231,GO:0050900,GO:0070062,GO:0070327,GO:0089718,GO:0098591,GO:0098713,GO:0150104,GO:1902475,GO:1903801,GO:1904556,GO:1990184" positive regulation of cytokine production involved in immune response|amino acid transmembrane transport|protein binding|lysosomal membrane|cytosol|plasma membrane|basal plasma membrane|negative regulation of gene expression|amino acid transmembrane transporter activity|aromatic amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-leucine transmembrane transporter activity|L-tryptophan transmembrane transporter activity|thyroid hormone transmembrane transporter activity|neutral amino acid transport|phenylalanine transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|microvillus membrane|positive regulation of interferon-gamma production|positive regulation of interleukin-17 production|positive regulation of interleukin-4 production|peptide antigen binding|xenobiotic transport|intracellular membrane-bounded organelle|leukocyte migration|extracellular exosome|thyroid hormone transport|amino acid import across plasma membrane|external side of apical plasma membrane|leucine import across plasma membrane|transport across blood-brain barrier|L-alpha-amino acid transmembrane transport|L-leucine import across plasma membrane|L-tryptophan transmembrane transport|amino acid transport complex "hsa04150,hsa05230" mTOR signaling pathway|Central carbon metabolism in cancer SLC7A6 1186.23733 1177.348923 1195.125737 1.015099019 0.021620464 0.952302922 1 8.802564146 9.320378222 9057 solute carrier family 7 member 6 "GO:0003333,GO:0005515,GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015174,GO:0015179,GO:0015297,GO:0015807,GO:0015822,GO:0016323,GO:0043231,GO:0050900,GO:1902475,GO:1990822" amino acid transmembrane transport|protein binding|plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|basic amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|antiporter activity|L-amino acid transport|ornithine transport|basolateral plasma membrane|intracellular membrane-bounded organelle|leukocyte migration|L-alpha-amino acid transmembrane transport|basic amino acid transmembrane transport SLC7A6OS 343.3198658 367.4140606 319.225671 0.86884446 -0.202830165 0.658164854 1 4.224341886 3.828397512 84138 solute carrier family 7 member 6 opposite strand "GO:0002244,GO:0005634,GO:0005737,GO:0015031,GO:0032502" hematopoietic progenitor cell differentiation|nucleus|cytoplasm|protein transport|developmental process SLC7A7 14.58324956 20.29911937 8.867379749 0.436835687 -1.194837375 0.340422573 1 0.439162232 0.200105499 9056 solute carrier family 7 member 7 "GO:0000821,GO:0003333,GO:0005886,GO:0005887,GO:0006865,GO:0015174,GO:0015179,GO:0015807,GO:0016323,GO:0050900,GO:1902475,GO:1990822" regulation of arginine metabolic process|amino acid transmembrane transport|plasma membrane|integral component of plasma membrane|amino acid transport|basic amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-amino acid transport|basolateral plasma membrane|leukocyte migration|L-alpha-amino acid transmembrane transport|basic amino acid transmembrane transport hsa04974 Protein digestion and absorption SLC7A8 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.066128567 0.022319753 23428 solute carrier family 7 member 8 "GO:0003333,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006865,GO:0009636,GO:0009925,GO:0015101,GO:0015171,GO:0015175,GO:0015179,GO:0015180,GO:0015187,GO:0015190,GO:0015349,GO:0015695,GO:0015804,GO:0015816,GO:0015820,GO:0015827,GO:0015829,GO:0016323,GO:0016324,GO:0019534,GO:0031528,GO:0035524,GO:0042605,GO:0050900,GO:0055065,GO:0070327,GO:0089718,GO:0098713,GO:0150104,GO:1901998,GO:1903801,GO:1904273" amino acid transmembrane transport|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|amino acid transport|response to toxic substance|basal plasma membrane|organic cation transmembrane transporter activity|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|glycine transmembrane transporter activity|L-leucine transmembrane transporter activity|thyroid hormone transmembrane transporter activity|organic cation transport|neutral amino acid transport|glycine transport|leucine transport|tryptophan transport|valine transport|basolateral plasma membrane|apical plasma membrane|toxin transmembrane transporter activity|microvillus membrane|proline transmembrane transport|peptide antigen binding|leukocyte migration|metal ion homeostasis|thyroid hormone transport|amino acid import across plasma membrane|leucine import across plasma membrane|transport across blood-brain barrier|toxin transport|L-leucine import across plasma membrane|L-alanine import across plasma membrane hsa04974 Protein digestion and absorption SLC8A1 251.3272954 241.5595205 261.0950704 1.080872614 0.112196505 0.829364381 1 0.473787373 0.534163151 6546 solute carrier family 8 member A1 "GO:0002026,GO:0002027,GO:0002028,GO:0005432,GO:0005509,GO:0005515,GO:0005516,GO:0005654,GO:0005739,GO:0005874,GO:0005886,GO:0005887,GO:0006811,GO:0006874,GO:0006883,GO:0006936,GO:0007584,GO:0008092,GO:0009749,GO:0010468,GO:0010649,GO:0010763,GO:0010881,GO:0010882,GO:0014069,GO:0014704,GO:0014829,GO:0015491,GO:0016020,GO:0021537,GO:0030001,GO:0030018,GO:0030315,GO:0030424,GO:0030425,GO:0030501,GO:0030506,GO:0033198,GO:0035725,GO:0035902,GO:0035994,GO:0036376,GO:0042383,GO:0042493,GO:0042542,GO:0043025,GO:0043197,GO:0043198,GO:0043679,GO:0044325,GO:0044557,GO:0045202,GO:0051481,GO:0055013,GO:0055074,GO:0055119,GO:0060048,GO:0060401,GO:0060402,GO:0070509,GO:0070588,GO:0071313,GO:0071320,GO:0071456,GO:0071901,GO:0071944,GO:0086012,GO:0086064,GO:0098703,GO:0098719,GO:0098735,GO:0098794,GO:0099055,GO:0099566,GO:0099580,GO:1903779,GO:1905060" regulation of the force of heart contraction|regulation of heart rate|regulation of sodium ion transport|calcium:sodium antiporter activity|calcium ion binding|protein binding|calmodulin binding|nucleoplasm|mitochondrion|microtubule|plasma membrane|integral component of plasma membrane|ion transport|cellular calcium ion homeostasis|cellular sodium ion homeostasis|muscle contraction|response to nutrient|cytoskeletal protein binding|response to glucose|regulation of gene expression|regulation of cell communication by electrical coupling|positive regulation of fibroblast migration|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by calcium ion signaling|postsynaptic density|intercalated disc|vascular associated smooth muscle contraction|cation:cation antiporter activity|membrane|telencephalon development|metal ion transport|Z disc|T-tubule|axon|dendrite|positive regulation of bone mineralization|ankyrin binding|response to ATP|sodium ion transmembrane transport|response to immobilization stress|response to muscle stretch|sodium ion export across plasma membrane|sarcolemma|response to drug|response to hydrogen peroxide|neuronal cell body|dendritic spine|dendritic shaft|axon terminus|ion channel binding|relaxation of smooth muscle|synapse|negative regulation of cytosolic calcium ion concentration|cardiac muscle cell development|calcium ion homeostasis|relaxation of cardiac muscle|cardiac muscle contraction|cytosolic calcium ion transport|calcium ion transport into cytosol|calcium ion import|calcium ion transmembrane transport|cellular response to caffeine|cellular response to cAMP|cellular response to hypoxia|negative regulation of protein serine/threonine kinase activity|cell periphery|membrane depolarization during cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|calcium ion import across plasma membrane|sodium ion import across plasma membrane|positive regulation of the force of heart contraction|postsynapse|integral component of postsynaptic membrane|regulation of postsynaptic cytosolic calcium ion concentration|ion antiporter activity involved in regulation of postsynaptic membrane potential|regulation of cardiac conduction|calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration "hsa04020,hsa04022,hsa04260,hsa04261,hsa04371,hsa04740,hsa04961,hsa04974,hsa04978,hsa05410,hsa05412,hsa05414" Calcium signaling pathway|cGMP-PKG signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Olfactory transduction|Endocrine and other factor-regulated calcium reabsorption|Protein digestion and absorption|Mineral absorption|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy SLC8B1 877.9091971 810.9498187 944.8685755 1.165138155 0.220501031 0.542086001 1 12.10484747 14.71135499 80024 solute carrier family 8 member B1 "GO:0005432,GO:0005743,GO:0005886,GO:0006811,GO:0006812,GO:0006851,GO:0006874,GO:0008324,GO:0015368,GO:0016020,GO:0030061,GO:0032592,GO:0035725,GO:0042593,GO:0042803,GO:0050796,GO:0050896,GO:0051480,GO:0051560,GO:0086036,GO:0086038,GO:0099093,GO:1901623,GO:2001256" calcium:sodium antiporter activity|mitochondrial inner membrane|plasma membrane|ion transport|cation transport|mitochondrial calcium ion transmembrane transport|cellular calcium ion homeostasis|cation transmembrane transporter activity|calcium:cation antiporter activity|membrane|mitochondrial crista|integral component of mitochondrial membrane|sodium ion transmembrane transport|glucose homeostasis|protein homodimerization activity|regulation of insulin secretion|response to stimulus|regulation of cytosolic calcium ion concentration|mitochondrial calcium ion homeostasis|regulation of cardiac muscle cell membrane potential|calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential|calcium export from the mitochondrion|regulation of lymphocyte chemotaxis|regulation of store-operated calcium entry SLC9A1 648.6558332 630.2876564 667.02401 1.05828506 0.081728284 0.83489831 1 8.354317266 9.222094302 6548 solute carrier family 9 member A1 "GO:0005515,GO:0005516,GO:0005546,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0005925,GO:0006811,GO:0006883,GO:0006885,GO:0009986,GO:0010447,GO:0010613,GO:0010882,GO:0014704,GO:0015299,GO:0015385,GO:0015386,GO:0016021,GO:0016323,GO:0016324,GO:0016477,GO:0030011,GO:0030027,GO:0030214,GO:0030307,GO:0030315,GO:0030346,GO:0030674,GO:0032869,GO:0035794,GO:0035994,GO:0036376,GO:0043065,GO:0043066,GO:0045121,GO:0045760,GO:0045944,GO:0048306,GO:0048471,GO:0051259,GO:0051453,GO:0051492,GO:0051893,GO:0051930,GO:0055007,GO:0060090,GO:0070062,GO:0070417,GO:0070886,GO:0070997,GO:0071236,GO:0071257,GO:0071260,GO:0071456,GO:0071468,GO:0071805,GO:0071872,GO:0086003,GO:0086036,GO:0086040,GO:0086092,GO:0090533,GO:0098656,GO:0098719,GO:0098735,GO:1902600,GO:1903281" "protein binding|calmodulin binding|phosphatidylinositol-4,5-bisphosphate binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|focal adhesion|ion transport|cellular sodium ion homeostasis|regulation of pH|cell surface|response to acidic pH|positive regulation of cardiac muscle hypertrophy|regulation of cardiac muscle contraction by calcium ion signaling|intercalated disc|solute:proton antiporter activity|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cell migration|maintenance of cell polarity|lamellipodium|hyaluronan catabolic process|positive regulation of cell growth|T-tubule|protein phosphatase 2B binding|protein-macromolecule adaptor activity|cellular response to insulin stimulus|positive regulation of mitochondrial membrane permeability|response to muscle stretch|sodium ion export across plasma membrane|positive regulation of apoptotic process|negative regulation of apoptotic process|membrane raft|positive regulation of action potential|positive regulation of transcription by RNA polymerase II|calcium-dependent protein binding|perinuclear region of cytoplasm|protein complex oligomerization|regulation of intracellular pH|regulation of stress fiber assembly|regulation of focal adhesion assembly|regulation of sensory perception of pain|cardiac muscle cell differentiation|molecular adaptor activity|extracellular exosome|cellular response to cold|positive regulation of calcineurin-NFAT signaling cascade|neuron death|cellular response to antibiotic|cellular response to electrical stimulus|cellular response to mechanical stimulus|cellular response to hypoxia|cellular response to acidic pH|potassium ion transmembrane transport|cellular response to epinephrine stimulus|cardiac muscle cell contraction|regulation of cardiac muscle cell membrane potential|sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential|regulation of the force of heart contraction by cardiac conduction|cation-transporting ATPase complex|anion transmembrane transport|sodium ion import across plasma membrane|positive regulation of the force of heart contraction|proton transmembrane transport|positive regulation of calcium:sodium antiporter activity" "hsa04024,hsa04260,hsa04261,hsa04371,hsa04810,hsa04919,hsa04970,hsa04971,hsa04972,hsa04976,hsa05205" cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Proteoglycans in cancer SLC9A2 14.50902068 15.22433953 13.79370183 0.906029572 -0.142369955 0.969242346 1 0.13766454 0.130100927 6549 solute carrier family 9 member A2 "GO:0005886,GO:0006811,GO:0008104,GO:0015385,GO:0015386,GO:0016021,GO:0051453,GO:0071805,GO:0098656,GO:0098719,GO:1902600" plasma membrane|ion transport|protein localization|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|regulation of intracellular pH|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport SLC9A3 293.8272773 250.6941242 336.9604305 1.344109805 0.426651002 0.37104562 1 2.285647704 3.204497748 6550 solute carrier family 9 member A3 "GO:0005515,GO:0005886,GO:0005903,GO:0006811,GO:0009986,GO:0015385,GO:0015386,GO:0016021,GO:0016324,GO:0030165,GO:0031526,GO:0051453,GO:0070062,GO:0071805,GO:0098656,GO:0098719,GO:1902600" protein binding|plasma membrane|brush border|ion transport|cell surface|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|apical plasma membrane|PDZ domain binding|brush border membrane|regulation of intracellular pH|extracellular exosome|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport "hsa04964,hsa04974,hsa04976,hsa04978" Proximal tubule bicarbonate reclamation|Protein digestion and absorption|Bile secretion|Mineral absorption SLC9A3R1 953.7461034 977.4025975 930.0896092 0.951593142 -0.07158322 0.842860107 1 24.8379295 24.65372932 9368 SLC9A3 regulator 1 "GO:0001726,GO:0002009,GO:0003096,GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005902,GO:0007009,GO:0007097,GO:0007191,GO:0007605,GO:0008013,GO:0008285,GO:0008360,GO:0008361,GO:0010642,GO:0012505,GO:0014067,GO:0015185,GO:0015629,GO:0016020,GO:0016055,GO:0016324,GO:0017081,GO:0019902,GO:0022612,GO:0030033,GO:0030036,GO:0030165,GO:0030175,GO:0030336,GO:0030643,GO:0031526,GO:0031528,GO:0031698,GO:0031799,GO:0031800,GO:0031982,GO:0032415,GO:0032416,GO:0032426,GO:0032782,GO:0034635,GO:0034767,GO:0043495,GO:0043621,GO:0044062,GO:0044782,GO:0044877,GO:0045121,GO:0045159,GO:0045198,GO:0045199,GO:0045859,GO:0045930,GO:0047485,GO:0048471,GO:0050780,GO:0051683,GO:0051898,GO:0051939,GO:0060088,GO:0060158,GO:0065003,GO:0070062,GO:0070293,GO:0070373,GO:0070851,GO:0071944,GO:0072659,GO:0090090,GO:0090660,GO:0097225,GO:0097291,GO:0098739,GO:0098797,GO:0150104,GO:2001244" ruffle|morphogenesis of an epithelium|renal sodium ion transport|signaling receptor binding|protein binding|nucleus|cytoplasm|microvillus|plasma membrane organization|nuclear migration|adenylate cyclase-activating dopamine receptor signaling pathway|sensory perception of sound|beta-catenin binding|negative regulation of cell population proliferation|regulation of cell shape|regulation of cell size|negative regulation of platelet-derived growth factor receptor signaling pathway|endomembrane system|negative regulation of phosphatidylinositol 3-kinase signaling|gamma-aminobutyric acid transmembrane transporter activity|actin cytoskeleton|membrane|Wnt signaling pathway|apical plasma membrane|chloride channel regulator activity|phosphatase binding|gland morphogenesis|microvillus assembly|actin cytoskeleton organization|PDZ domain binding|filopodium|negative regulation of cell migration|cellular phosphate ion homeostasis|brush border membrane|microvillus membrane|beta-2 adrenergic receptor binding|type 2 metabotropic glutamate receptor binding|type 3 metabotropic glutamate receptor binding|vesicle|regulation of sodium:proton antiporter activity|negative regulation of sodium:proton antiporter activity|stereocilium tip|bile acid secretion|glutathione transport|positive regulation of ion transmembrane transport|protein-membrane adaptor activity|protein self-association|regulation of excretion|cilium organization|protein-containing complex binding|membrane raft|myosin II binding|establishment of epithelial cell apical/basal polarity|maintenance of epithelial cell apical/basal polarity|regulation of protein kinase activity|negative regulation of mitotic cell cycle|protein N-terminus binding|perinuclear region of cytoplasm|dopamine receptor binding|establishment of Golgi localization|negative regulation of protein kinase B signaling|gamma-aminobutyric acid import|auditory receptor cell stereocilium organization|phospholipase C-activating dopamine receptor signaling pathway|protein-containing complex assembly|extracellular exosome|renal absorption|negative regulation of ERK1 and ERK2 cascade|growth factor receptor binding|cell periphery|protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway|cerebrospinal fluid circulation|sperm midpiece|renal phosphate ion absorption|import across plasma membrane|plasma membrane protein complex|transport across blood-brain barrier|positive regulation of intrinsic apoptotic signaling pathway "hsa04530,hsa04928,hsa05130,hsa05165" "Tight junction|Parathyroid hormone synthesis, secretion and action|Pathogenic Escherichia coli infection|Human papillomavirus infection" SLC9A3R2 580.2123694 598.8240213 561.6007174 0.937839327 -0.092587316 0.817811782 1 5.390743718 5.273428424 9351 SLC9A3 regulator 2 "GO:0005102,GO:0005515,GO:0005634,GO:0005886,GO:0005925,GO:0008013,GO:0008022,GO:0012505,GO:0016324,GO:0019902,GO:0031799,GO:0031800,GO:0042802,GO:0043495,GO:0045296,GO:0065003,GO:0070062,GO:0072659" signaling receptor binding|protein binding|nucleus|plasma membrane|focal adhesion|beta-catenin binding|protein C-terminus binding|endomembrane system|apical plasma membrane|phosphatase binding|type 2 metabotropic glutamate receptor binding|type 3 metabotropic glutamate receptor binding|identical protein binding|protein-membrane adaptor activity|cadherin binding|protein-containing complex assembly|extracellular exosome|protein localization to plasma membrane hsa04960 Aldosterone-regulated sodium reabsorption SLC9A5 94.02520387 96.420817 91.62959074 0.950309213 -0.073531078 0.931195429 1 0.950442629 0.9421212 6553 solute carrier family 9 member A5 "GO:0005886,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0051453,GO:0071805,GO:0098656,GO:0098719,GO:1902600" plasma membrane|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|regulation of intracellular pH|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport SLC9A6 969.7411855 892.1462962 1047.336075 1.173951043 0.231372245 0.514490448 1 8.647667483 10.58924259 10479 solute carrier family 9 member A6 "GO:0005739,GO:0005789,GO:0005886,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0031901,GO:0043231,GO:0048675,GO:0048812,GO:0051453,GO:0055037,GO:0055038,GO:0071805,GO:0097484,GO:0098656,GO:0098719,GO:1902600" mitochondrion|endoplasmic reticulum membrane|plasma membrane|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|early endosome membrane|intracellular membrane-bounded organelle|axon extension|neuron projection morphogenesis|regulation of intracellular pH|recycling endosome|recycling endosome membrane|potassium ion transmembrane transport|dendrite extension|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport hsa04260 Cardiac muscle contraction SLC9A7 1771.097911 1891.877925 1650.317898 0.872317329 -0.197075046 0.545367186 1 9.567343261 8.70526078 84679 solute carrier family 9 member A7 "GO:0000139,GO:0005515,GO:0005802,GO:0005886,GO:0006811,GO:0006885,GO:0015385,GO:0015386,GO:0016021,GO:0043231,GO:0051453,GO:0055037,GO:0055038,GO:0071805,GO:0098656,GO:0098719,GO:1902600,GO:1905526" Golgi membrane|protein binding|trans-Golgi network|plasma membrane|ion transport|regulation of pH|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|intracellular membrane-bounded organelle|regulation of intracellular pH|recycling endosome|recycling endosome membrane|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport|regulation of Golgi lumen acidification hsa04260 Cardiac muscle contraction SLC9A8 902.7889803 1063.673855 741.9041057 0.697492095 -0.519751228 0.147800163 1 7.094867422 5.161780162 23315 solute carrier family 9 member A8 "GO:0000139,GO:0005515,GO:0005794,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0035725,GO:0051453,GO:0071805,GO:0098656,GO:1902600" Golgi membrane|protein binding|Golgi apparatus|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|sodium ion transmembrane transport|regulation of intracellular pH|potassium ion transmembrane transport|anion transmembrane transport|proton transmembrane transport SLC9A9 17.53904281 20.29911937 14.77896625 0.728059478 -0.457871781 0.725187077 1 0.112149971 0.08516908 285195 solute carrier family 9 member A9 "GO:0005515,GO:0005886,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0031902,GO:0051453,GO:0055037,GO:0071805,GO:0098656,GO:0098719,GO:1902600" protein binding|plasma membrane|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|late endosome membrane|regulation of intracellular pH|recycling endosome|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport SLC9B2 141.5851198 114.6900244 168.4802152 1.469004964 0.554839271 0.359782681 1 0.653832185 1.001856427 133308 solute carrier family 9 member B2 "GO:0005451,GO:0005515,GO:0005743,GO:0005886,GO:0006814,GO:0010008,GO:0010348,GO:0015385,GO:0015672,GO:0016021,GO:0016323,GO:0016324,GO:0030317,GO:0030672,GO:0031966,GO:0034220,GO:0035725,GO:0042802,GO:0061178,GO:0072583,GO:0097228,GO:1902600,GO:2001206" monovalent cation:proton antiporter activity|protein binding|mitochondrial inner membrane|plasma membrane|sodium ion transport|endosome membrane|lithium:proton antiporter activity|sodium:proton antiporter activity|monovalent inorganic cation transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|flagellated sperm motility|synaptic vesicle membrane|mitochondrial membrane|ion transmembrane transport|sodium ion transmembrane transport|identical protein binding|regulation of insulin secretion involved in cellular response to glucose stimulus|clathrin-dependent endocytosis|sperm principal piece|proton transmembrane transport|positive regulation of osteoclast development SLC9C1 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.025591075 0.008637515 285335 solute carrier family 9 member C1 "GO:0005216,GO:0005886,GO:0007275,GO:0007283,GO:0015385,GO:0015386,GO:0016021,GO:0030154,GO:0030317,GO:0031514,GO:0051453,GO:0071805,GO:0098656,GO:0098719,GO:1902600" ion channel activity|plasma membrane|multicellular organism development|spermatogenesis|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|cell differentiation|flagellated sperm motility|motile cilium|regulation of intracellular pH|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport SLCO3A1 306.8287098 263.8885518 349.7688679 1.325441614 0.40647312 0.387726259 1 2.239823061 3.096636604 28232 solute carrier organic anion transporter family member 3A1 "GO:0001934,GO:0005886,GO:0005887,GO:0015347,GO:0015732,GO:0043252,GO:0051092,GO:0055085,GO:0150104" positive regulation of protein phosphorylation|plasma membrane|integral component of plasma membrane|sodium-independent organic anion transmembrane transporter activity|prostaglandin transport|sodium-independent organic anion transport|positive regulation of NF-kappaB transcription factor activity|transmembrane transport|transport across blood-brain barrier SLCO4A1 8422.169437 12739.72732 4104.611559 0.322189907 -1.634016794 1.55E-06 0.000618379 107.0020308 35.96001642 28231 solute carrier organic anion transporter family member 4A1 "GO:0005515,GO:0005886,GO:0005887,GO:0015347,GO:0015349,GO:0043252,GO:0055085,GO:0070327" protein binding|plasma membrane|integral component of plasma membrane|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity|sodium-independent organic anion transport|transmembrane transport|thyroid hormone transport SLCO5A1 24.97306326 23.34398727 26.60213925 1.139571357 0.188491265 0.893454748 1 0.106541462 0.126641518 81796 solute carrier organic anion transporter family member 5A1 "GO:0005886,GO:0005887,GO:0015347,GO:0043231,GO:0043252,GO:0055085" plasma membrane|integral component of plasma membrane|sodium-independent organic anion transmembrane transporter activity|intracellular membrane-bounded organelle|sodium-independent organic anion transport|transmembrane transport SLF1 367.4021825 329.8606897 404.9436752 1.227620289 0.295864395 0.507439504 1 1.242841858 1.591460481 84250 SMC5-SMC6 complex localization factor 1 "GO:0000786,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006281,GO:0006974,GO:0031334,GO:0031625,GO:0034184,GO:0035861,GO:0042405,GO:0044877,GO:1990166,GO:2000781" nucleosome|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|DNA repair|cellular response to DNA damage stimulus|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|positive regulation of maintenance of mitotic sister chromatid cohesion|site of double-strand break|nuclear inclusion body|protein-containing complex binding|protein localization to site of double-strand break|positive regulation of double-strand break repair SLF2 3224.291918 3133.169074 3315.414762 1.058166566 0.081566741 0.798272291 1 14.21007974 15.68434838 55719 SMC5-SMC6 complex localization factor 2 "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006974,GO:0031334,GO:0031625,GO:0034184,GO:0035861,GO:0043231,GO:0044877,GO:1990166,GO:2000781" chromatin|protein binding|nucleus|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|positive regulation of maintenance of mitotic sister chromatid cohesion|site of double-strand break|intracellular membrane-bounded organelle|protein-containing complex binding|protein localization to site of double-strand break|positive regulation of double-strand break repair SLFN11 1235.542367 1213.887338 1257.197396 1.035678811 0.050576658 0.884136322 1 11.82063283 12.76973099 91607 schlafen family member 11 "GO:0000049,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006974,GO:0008156,GO:0010942,GO:0016887,GO:0043111,GO:0051607,GO:0090734,GO:2000134" tRNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|cellular response to DNA damage stimulus|negative regulation of DNA replication|positive regulation of cell death|ATPase activity|replication fork arrest|defense response to virus|site of DNA damage|negative regulation of G1/S transition of mitotic cell cycle SLFN12 555.8385804 549.0911789 562.5859818 1.024576616 0.03502787 0.934571294 1 5.808172751 6.207259394 55106 schlafen family member 12 GO:0005515 protein binding SLFN12L 5.985815379 5.074779842 6.896850916 1.359044359 0.442592546 0.890504047 1 0.05259253 0.07455446 100506736 schlafen family member 12 like GO:0016021 integral component of membrane SLFN13 69.45569816 66.98709391 71.92430241 1.073703876 0.102596158 0.911977177 1 0.330025291 0.369613371 146857 schlafen family member 13 "GO:0000049,GO:0004521,GO:0005524,GO:0005737,GO:0008270,GO:0016075,GO:0016078,GO:0051607,GO:0090502" "tRNA binding|endoribonuclease activity|ATP binding|cytoplasm|zinc ion binding|rRNA catabolic process|tRNA catabolic process|defense response to virus|RNA phosphodiester bond hydrolysis, endonucleolytic" SLFN5 1941.43657 1985.253874 1897.619266 0.955857229 -0.065132948 0.841480102 1 9.525921854 9.497645883 162394 schlafen family member 5 "GO:0005524,GO:0005634,GO:0030154" ATP binding|nucleus|cell differentiation SLFNL1 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.02811519 0.047447278 200172 schlafen like 1 GO:0005524 ATP binding SLIRP 576.2928385 701.3345741 451.2511028 0.643417734 -0.636172394 0.107346686 1 83.77387269 56.22345749 81892 SRA stem-loop interacting RNA binding protein "GO:0000961,GO:0003723,GO:0005515,GO:0005634,GO:0005739,GO:0070584" negative regulation of mitochondrial RNA catabolic process|RNA binding|protein binding|nucleus|mitochondrion|mitochondrion morphogenesis SLIT2 291.3829214 386.698224 196.0676189 0.507030048 -0.979856848 0.040966569 0.930085222 1.908859732 1.009540261 9353 slit guidance ligand 2 "GO:0001657,GO:0001933,GO:0002042,GO:0002689,GO:0003180,GO:0003184,GO:0005095,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0007411,GO:0008045,GO:0008201,GO:0010593,GO:0010596,GO:0014912,GO:0016020,GO:0021834,GO:0021836,GO:0021972,GO:0030308,GO:0030336,GO:0030837,GO:0031290,GO:0032870,GO:0034260,GO:0035385,GO:0042802,GO:0042803,GO:0043065,GO:0043116,GO:0043237,GO:0043394,GO:0048495,GO:0048754,GO:0048846,GO:0050772,GO:0050919,GO:0050929,GO:0051058,GO:0051414,GO:0060412,GO:0061364,GO:0070062,GO:0070100,GO:0071504,GO:0071672,GO:0071676,GO:0090024,GO:0090027,GO:0090260,GO:0090288" ureteric bud development|negative regulation of protein phosphorylation|cell migration involved in sprouting angiogenesis|negative regulation of leukocyte chemotaxis|aortic valve morphogenesis|pulmonary valve morphogenesis|GTPase inhibitor activity|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|plasma membrane|axon guidance|motor neuron axon guidance|heparin binding|negative regulation of lamellipodium assembly|negative regulation of endothelial cell migration|negative regulation of smooth muscle cell migration|membrane|chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|negative regulation of cell growth|negative regulation of cell migration|negative regulation of actin filament polymerization|retinal ganglion cell axon guidance|cellular response to hormone stimulus|negative regulation of GTPase activity|Roundabout signaling pathway|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of vascular permeability|laminin-1 binding|proteoglycan binding|Roundabout binding|branching morphogenesis of an epithelial tube|axon extension involved in axon guidance|positive regulation of axonogenesis|negative chemotaxis|induction of negative chemotaxis|negative regulation of small GTPase mediated signal transduction|response to cortisol|ventricular septum morphogenesis|apoptotic process involved in luteolysis|extracellular exosome|negative regulation of chemokine-mediated signaling pathway|cellular response to heparin|negative regulation of smooth muscle cell chemotaxis|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of monocyte chemotaxis|negative regulation of retinal ganglion cell axon guidance|negative regulation of cellular response to growth factor stimulus hsa04360 Axon guidance SLITRK3 14.00154269 14.20938356 13.79370183 0.970745971 -0.042834281 1 1 0.135963565 0.137671508 22865 SLIT and NTRK like family member 3 "GO:0005515,GO:0005886,GO:0007409,GO:0051965,GO:0098982,GO:0099060,GO:0099061,GO:0099560,GO:1905606" protein binding|plasma membrane|axonogenesis|positive regulation of synapse assembly|GABA-ergic synapse|integral component of postsynaptic specialization membrane|integral component of postsynaptic density membrane|synaptic membrane adhesion|regulation of presynapse assembly SLITRK4 480.9342364 480.074173 481.7942997 1.003583044 0.00516 0.995791213 1 2.58056286 2.701367603 139065 SLIT and NTRK like family member 4 "GO:0005886,GO:0007409,GO:0016021,GO:0050807,GO:0098978,GO:1905606" plasma membrane|axonogenesis|integral component of membrane|regulation of synapse organization|glutamatergic synapse|regulation of presynapse assembly SLITRK5 10.53827146 13.19442759 7.882115332 0.597382136 -0.743273999 0.622951235 1 0.118003039 0.073529456 26050 SLIT and NTRK like family member 5 "GO:0005515,GO:0005886,GO:0007268,GO:0007409,GO:0007625,GO:0009410,GO:0016021,GO:0021756,GO:0030534,GO:0043235,GO:0043588,GO:0045202,GO:0048813,GO:0051965,GO:0072359,GO:1905606" protein binding|plasma membrane|chemical synaptic transmission|axonogenesis|grooming behavior|response to xenobiotic stimulus|integral component of membrane|striatum development|adult behavior|receptor complex|skin development|synapse|dendrite morphogenesis|positive regulation of synapse assembly|circulatory system development|regulation of presynapse assembly SLK 4410.190517 4253.680463 4566.700571 1.073588063 0.102440536 0.748909225 1 27.38450609 30.66609779 9748 STE20 like kinase "GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006915,GO:0030334,GO:0031122,GO:0031252,GO:0042802,GO:0042803,GO:0042981,GO:0045296,GO:0046777,GO:0048471,GO:0051893,GO:0070062,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|apoptotic process|regulation of cell migration|cytoplasmic microtubule organization|cell leading edge|identical protein binding|protein homodimerization activity|regulation of apoptotic process|cadherin binding|protein autophosphorylation|perinuclear region of cytoplasm|regulation of focal adhesion assembly|extracellular exosome|protein serine kinase activity|protein threonine kinase activity hsa04114 Oocyte meiosis SLMAP 1975.451203 1885.788189 2065.114217 1.095093409 0.131053934 0.685300767 1 14.28698865 16.31953555 7871 sarcolemma associated protein "GO:0005515,GO:0005790,GO:0005815,GO:0005887,GO:0006936,GO:0042383,GO:0072659,GO:1900825,GO:1902305,GO:1905150" protein binding|smooth endoplasmic reticulum|microtubule organizing center|integral component of plasma membrane|muscle contraction|sarcolemma|protein localization to plasma membrane|regulation of membrane depolarization during cardiac muscle cell action potential|regulation of sodium ion transmembrane transport|regulation of voltage-gated sodium channel activity SLPI 93.63377049 137.0190557 50.24848524 0.366726256 -1.447224536 0.039056888 0.906467561 11.64350973 4.453914176 6590 secretory leukocyte peptidase inhibitor "GO:0003677,GO:0003729,GO:0004866,GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0006955,GO:0010951,GO:0019731,GO:0019899,GO:0032091,GO:0032496,GO:0035580,GO:0035821,GO:0043312,GO:0045071,GO:0045087,GO:0062023,GO:0070062" DNA binding|mRNA binding|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|Golgi apparatus|immune response|negative regulation of endopeptidase activity|antibacterial humoral response|enzyme binding|negative regulation of protein binding|response to lipopolysaccharide|specific granule lumen|modulation of process of other organism|neutrophil degranulation|negative regulation of viral genome replication|innate immune response|collagen-containing extracellular matrix|extracellular exosome SLTM 1559.439014 1600.585562 1518.292466 0.948585631 -0.07615008 0.81901652 1 11.72292295 11.59920922 79811 SAFB like transcription modulator "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006915,GO:0016604,GO:0043565,GO:0050684" RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|apoptotic process|nuclear body|sequence-specific DNA binding|regulation of mRNA processing SLU7 1154.497069 1028.150396 1280.843742 1.245774691 0.317043168 0.357113753 1 12.89873432 16.76110052 10569 "SLU7 homolog, splicing factor" "GO:0000375,GO:0000380,GO:0000386,GO:0000389,GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0006886,GO:0008270,GO:0008380,GO:0016020,GO:0016607,GO:0030532,GO:0030628,GO:0031124,GO:0034605,GO:0043231,GO:0071013" "RNA splicing, via transesterification reactions|alternative mRNA splicing, via spliceosome|second spliceosomal transesterification activity|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|intracellular protein transport|zinc ion binding|RNA splicing|membrane|nuclear speck|small nuclear ribonucleoprotein complex|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|cellular response to heat|intracellular membrane-bounded organelle|catalytic step 2 spliceosome" hsa03040 Spliceosome SLX1A 26.52518876 28.41876711 24.63161041 0.866737474 -0.206333014 0.87428341 1 1.235459484 1.116945573 548593 "SLX1 homolog A, structure-specific endonuclease subunit" "GO:0000724,GO:0005515,GO:0005654,GO:0006281,GO:0008821,GO:0010792,GO:0010833,GO:0017108,GO:0033557,GO:0036297,GO:0046872,GO:0061820,GO:0090305,GO:0090656,GO:1904357,GO:1904431" double-strand break repair via homologous recombination|protein binding|nucleoplasm|DNA repair|crossover junction endodeoxyribonuclease activity|DNA double-strand break processing involved in repair via single-strand annealing|telomere maintenance via telomere lengthening|5'-flap endonuclease activity|Slx1-Slx4 complex|interstrand cross-link repair|metal ion binding|telomeric D-loop disassembly|nucleic acid phosphodiester bond hydrolysis|t-circle formation|negative regulation of telomere maintenance via telomere lengthening|positive regulation of t-circle formation hsa03460 Fanconi anemia pathway SLX1B 151.6686154 29.43372308 273.9035078 9.305771717 3.218125796 8.52E-07 0.000398029 1.279583037 12.42043477 79008 "SLX1 homolog B, structure-specific endonuclease subunit" "GO:0000724,GO:0005515,GO:0005654,GO:0006281,GO:0008821,GO:0010792,GO:0010833,GO:0017108,GO:0033557,GO:0036297,GO:0046872,GO:0061820,GO:0090305,GO:0090656,GO:1904357,GO:1904431" double-strand break repair via homologous recombination|protein binding|nucleoplasm|DNA repair|crossover junction endodeoxyribonuclease activity|DNA double-strand break processing involved in repair via single-strand annealing|telomere maintenance via telomere lengthening|5'-flap endonuclease activity|Slx1-Slx4 complex|interstrand cross-link repair|metal ion binding|telomeric D-loop disassembly|nucleic acid phosphodiester bond hydrolysis|t-circle formation|negative regulation of telomere maintenance via telomere lengthening|positive regulation of t-circle formation hsa03460 Fanconi anemia pathway SLX4 392.1768074 406.9973433 377.3562715 0.927171338 -0.109092126 0.807175603 1 1.995448174 1.929818122 84464 SLX4 structure-specific endonuclease subunit "GO:0000706,GO:0000712,GO:0000724,GO:0000781,GO:0000785,GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0006260,GO:0006281,GO:0006289,GO:0008047,GO:0008821,GO:0010792,GO:0017108,GO:0019899,GO:0030054,GO:0033557,GO:0036297,GO:0046872,GO:0048257,GO:0048476,GO:0050790,GO:0061820,GO:0070522,GO:0072429,GO:0090656,GO:1904357,GO:1904431" "meiotic DNA double-strand break processing|resolution of meiotic recombination intermediates|double-strand break repair via homologous recombination|chromosome, telomeric region|chromatin|DNA binding|protein binding|nucleoplasm|cytosol|DNA replication|DNA repair|nucleotide-excision repair|enzyme activator activity|crossover junction endodeoxyribonuclease activity|DNA double-strand break processing involved in repair via single-strand annealing|5'-flap endonuclease activity|enzyme binding|cell junction|Slx1-Slx4 complex|interstrand cross-link repair|metal ion binding|3'-flap endonuclease activity|Holliday junction resolvase complex|regulation of catalytic activity|telomeric D-loop disassembly|ERCC4-ERCC1 complex|response to intra-S DNA damage checkpoint signaling|t-circle formation|negative regulation of telomere maintenance via telomere lengthening|positive regulation of t-circle formation" hsa03460 Fanconi anemia pathway SLX4IP 320.7060431 336.9653815 304.4467047 0.903495497 -0.146410685 0.756697922 1 1.300869566 1.225958235 128710 SLX4 interacting protein GO:0005515 protein binding SMAD1 419.1082753 395.8328277 442.383723 1.117602412 0.16040704 0.711355914 1 6.912943554 8.058723795 4086 SMAD family member 1 "GO:0000165,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001657,GO:0001710,GO:0002051,GO:0003700,GO:0005515,GO:0005634,GO:0005637,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006468,GO:0006954,GO:0007165,GO:0007179,GO:0007183,GO:0007276,GO:0008285,GO:0009653,GO:0009880,GO:0010628,GO:0016021,GO:0016579,GO:0017151,GO:0019901,GO:0030154,GO:0030509,GO:0030901,GO:0030902,GO:0031053,GO:0032991,GO:0042592,GO:0042802,GO:0045669,GO:0045944,GO:0046872,GO:0051216,GO:0060038,GO:0060348,GO:0060395,GO:0061036,GO:0070410,GO:0070411,GO:0070878,GO:0071141,GO:0071144,GO:0071407,GO:1901522,GO:1902895,GO:1903672" "MAPK cascade|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|ureteric bud development|mesodermal cell fate commitment|osteoblast fate commitment|DNA-binding transcription factor activity|protein binding|nucleus|nuclear inner membrane|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|protein phosphorylation|inflammatory response|signal transduction|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|gamete generation|negative regulation of cell population proliferation|anatomical structure morphogenesis|embryonic pattern specification|positive regulation of gene expression|integral component of membrane|protein deubiquitination|DEAD/H-box RNA helicase binding|protein kinase binding|cell differentiation|BMP signaling pathway|midbrain development|hindbrain development|primary miRNA processing|protein-containing complex|homeostatic process|identical protein binding|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|cartilage development|cardiac muscle cell proliferation|bone development|SMAD protein signal transduction|positive regulation of cartilage development|co-SMAD binding|I-SMAD binding|primary miRNA binding|SMAD protein complex|heteromeric SMAD protein complex|cellular response to organic cyclic compound|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of sprouting angiogenesis" "hsa04350,hsa04390,hsa04550,hsa05202" TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer MH1 SMAD2 1645.537565 1693.961511 1597.113619 0.942827572 -0.084934145 0.797026624 1 2.059959052 2.025847697 4087 SMAD family member 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0001657,GO:0001701,GO:0001706,GO:0001707,GO:0003677,GO:0003682,GO:0003690,GO:0003700,GO:0005160,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0007179,GO:0007182,GO:0007183,GO:0007352,GO:0007369,GO:0008134,GO:0008285,GO:0009653,GO:0009749,GO:0009791,GO:0009952,GO:0010718,GO:0016579,GO:0017015,GO:0019902,GO:0023019,GO:0030073,GO:0030154,GO:0030324,GO:0030325,GO:0030509,GO:0030512,GO:0030513,GO:0031016,GO:0031053,GO:0031625,GO:0032444,GO:0032924,GO:0032991,GO:0033613,GO:0034713,GO:0035019,GO:0035265,GO:0035556,GO:0038092,GO:0042060,GO:0045165,GO:0045892,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0048156,GO:0048340,GO:0048617,GO:0048701,GO:0051098,GO:0060039,GO:0060395,GO:0062009,GO:0070410,GO:0070411,GO:0070412,GO:0070723,GO:0071141,GO:0071144,GO:0097718,GO:1900224" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|ureteric bud development|in utero embryonic development|endoderm formation|mesoderm formation|DNA binding|chromatin binding|double-stranded DNA binding|DNA-binding transcription factor activity|transforming growth factor beta receptor binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|SMAD protein complex assembly|zygotic specification of dorsal/ventral axis|gastrulation|transcription factor binding|negative regulation of cell population proliferation|anatomical structure morphogenesis|response to glucose|post-embryonic development|anterior/posterior pattern specification|positive regulation of epithelial to mesenchymal transition|protein deubiquitination|regulation of transforming growth factor beta receptor signaling pathway|phosphatase binding|signal transduction involved in regulation of gene expression|insulin secretion|cell differentiation|lung development|adrenal gland development|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of BMP signaling pathway|pancreas development|primary miRNA processing|ubiquitin protein ligase binding|activin responsive factor complex|activin receptor signaling pathway|protein-containing complex|activating transcription factor binding|type I transforming growth factor beta receptor binding|somatic stem cell population maintenance|organ growth|intracellular signal transduction|nodal signaling pathway|wound healing|cell fate commitment|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|tau protein binding|paraxial mesoderm morphogenesis|embryonic foregut morphogenesis|embryonic cranial skeleton morphogenesis|regulation of binding|pericardium development|SMAD protein signal transduction|secondary palate development|co-SMAD binding|I-SMAD binding|R-SMAD binding|response to cholesterol|SMAD protein complex|heteromeric SMAD protein complex|disordered domain specific binding|positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" "hsa04110,hsa04144,hsa04218,hsa04350,hsa04371,hsa04390,hsa04550,hsa04659,hsa04926,hsa04933,hsa05142,hsa05166,hsa05200,hsa05205,hsa05210,hsa05212,hsa05225,hsa05226,hsa05321" Cell cycle|Endocytosis|Cellular senescence|TGF-beta signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Th17 cell differentiation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Pancreatic cancer|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease MH1 SMAD3 7578.336217 6848.922875 8307.74956 1.213000893 0.278580612 0.397717372 1 47.75902272 60.42720148 4088 SMAD family member 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001102,GO:0001223,GO:0001228,GO:0001657,GO:0001666,GO:0001701,GO:0001707,GO:0001756,GO:0001889,GO:0001947,GO:0002076,GO:0002520,GO:0003700,GO:0005160,GO:0005515,GO:0005518,GO:0005634,GO:0005637,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006919,GO:0006955,GO:0007050,GO:0007179,GO:0007183,GO:0007492,GO:0008013,GO:0008134,GO:0008270,GO:0009653,GO:0009880,GO:0010628,GO:0010694,GO:0010718,GO:0016032,GO:0016202,GO:0016579,GO:0017015,GO:0017151,GO:0019901,GO:0019902,GO:0023019,GO:0030154,GO:0030308,GO:0030325,GO:0030335,GO:0030501,GO:0030509,GO:0030512,GO:0030878,GO:0031053,GO:0031490,GO:0031625,GO:0031962,GO:0032332,GO:0032731,GO:0032909,GO:0032916,GO:0032924,GO:0033689,GO:0035259,GO:0038092,GO:0042060,GO:0042110,GO:0042177,GO:0042307,GO:0042802,GO:0042803,GO:0043066,GO:0043130,GO:0043235,GO:0043425,GO:0043565,GO:0045216,GO:0045429,GO:0045599,GO:0045668,GO:0045893,GO:0045930,GO:0045944,GO:0048340,GO:0048589,GO:0048617,GO:0048701,GO:0050678,GO:0050728,GO:0050776,GO:0050821,GO:0050927,GO:0051091,GO:0051098,GO:0051481,GO:0051496,GO:0051894,GO:0060039,GO:0060290,GO:0060395,GO:0061045,GO:0061767,GO:0070306,GO:0070410,GO:0070411,GO:0070412,GO:0071141,GO:0071144,GO:0071345,GO:0071560,GO:0090263,GO:0097191,GO:0097296,GO:1901203,GO:1902895,GO:1903243" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|ureteric bud development|response to hypoxia|in utero embryonic development|mesoderm formation|somitogenesis|liver development|heart looping|osteoblast development|immune system development|DNA-binding transcription factor activity|transforming growth factor beta receptor binding|protein binding|collagen binding|nucleus|nuclear inner membrane|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|activation of cysteine-type endopeptidase activity involved in apoptotic process|immune response|cell cycle arrest|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|endoderm development|beta-catenin binding|transcription factor binding|zinc ion binding|anatomical structure morphogenesis|embryonic pattern specification|positive regulation of gene expression|positive regulation of alkaline phosphatase activity|positive regulation of epithelial to mesenchymal transition|viral process|regulation of striated muscle tissue development|protein deubiquitination|regulation of transforming growth factor beta receptor signaling pathway|DEAD/H-box RNA helicase binding|protein kinase binding|phosphatase binding|signal transduction involved in regulation of gene expression|cell differentiation|negative regulation of cell growth|adrenal gland development|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|thyroid gland development|primary miRNA processing|chromatin DNA binding|ubiquitin protein ligase binding|mineralocorticoid receptor binding|positive regulation of chondrocyte differentiation|positive regulation of interleukin-1 beta production|regulation of transforming growth factor beta2 production|positive regulation of transforming growth factor beta3 production|activin receptor signaling pathway|negative regulation of osteoblast proliferation|glucocorticoid receptor binding|nodal signaling pathway|wound healing|T cell activation|negative regulation of protein catabolic process|positive regulation of protein import into nucleus|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|ubiquitin binding|receptor complex|bHLH transcription factor binding|sequence-specific DNA binding|cell-cell junction organization|positive regulation of nitric oxide biosynthetic process|negative regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|paraxial mesoderm morphogenesis|developmental growth|embryonic foregut morphogenesis|embryonic cranial skeleton morphogenesis|regulation of epithelial cell proliferation|negative regulation of inflammatory response|regulation of immune response|protein stabilization|positive regulation of positive chemotaxis|positive regulation of DNA-binding transcription factor activity|regulation of binding|negative regulation of cytosolic calcium ion concentration|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|pericardium development|transdifferentiation|SMAD protein signal transduction|negative regulation of wound healing|negative regulation of lung blood pressure|lens fiber cell differentiation|co-SMAD binding|I-SMAD binding|R-SMAD binding|SMAD protein complex|heteromeric SMAD protein complex|cellular response to cytokine stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|positive regulation of extracellular matrix assembly|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of cardiac muscle hypertrophy in response to stress" "hsa04068,hsa04110,hsa04144,hsa04218,hsa04310,hsa04350,hsa04371,hsa04390,hsa04520,hsa04550,hsa04659,hsa04933,hsa05161,hsa05166,hsa05200,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321" FoxO signaling pathway|Cell cycle|Endocytosis|Cellular senescence|Wnt signaling pathway|TGF-beta signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Th17 cell differentiation|AGE-RAGE signaling pathway in diabetic complications|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease MH1 SMAD4 1746.671666 1569.121927 1924.221406 1.22630458 0.294317349 0.366725097 1 9.059563392 11.58834852 4089 SMAD family member 4 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001085,GO:0001223,GO:0001228,GO:0001541,GO:0001658,GO:0001666,GO:0001701,GO:0001702,GO:0003148,GO:0003190,GO:0003198,GO:0003220,GO:0003251,GO:0003360,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005518,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0005829,GO:0006357,GO:0006879,GO:0007179,GO:0007183,GO:0007283,GO:0007338,GO:0007411,GO:0008283,GO:0008285,GO:0009653,GO:0010614,GO:0010718,GO:0010862,GO:0014033,GO:0016579,GO:0017015,GO:0030154,GO:0030308,GO:0030509,GO:0030511,GO:0030513,GO:0032444,GO:0032525,GO:0032909,GO:0033686,GO:0035019,GO:0035556,GO:0036302,GO:0042118,GO:0042733,GO:0042802,GO:0042803,GO:0043199,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0046881,GO:0048382,GO:0048589,GO:0048663,GO:0048733,GO:0048859,GO:0051098,GO:0051571,GO:0051797,GO:0060065,GO:0060391,GO:0060395,GO:0060412,GO:0060548,GO:0060956,GO:0061040,GO:0062009,GO:0070102,GO:0070373,GO:0070411,GO:0070412,GO:0071141,GO:0071144,GO:0071559,GO:0071773,GO:0072133,GO:0072134,GO:0072520,GO:0140537,GO:1901522,GO:1902895,GO:1905305,GO:2000617" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|ovarian follicle development|branching involved in ureteric bud morphogenesis|response to hypoxia|in utero embryonic development|gastrulation with mouth forming second|outflow tract septum morphogenesis|atrioventricular valve formation|epithelial to mesenchymal transition involved in endocardial cushion formation|left ventricular cardiac muscle tissue morphogenesis|positive regulation of cell proliferation involved in heart valve morphogenesis|brainstem development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|collagen binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|centrosome|cytosol|regulation of transcription by RNA polymerase II|cellular iron ion homeostasis|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|spermatogenesis|single fertilization|axon guidance|cell population proliferation|negative regulation of cell population proliferation|anatomical structure morphogenesis|negative regulation of cardiac muscle hypertrophy|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|neural crest cell differentiation|protein deubiquitination|regulation of transforming growth factor beta receptor signaling pathway|cell differentiation|negative regulation of cell growth|BMP signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of BMP signaling pathway|activin responsive factor complex|somite rostral/caudal axis specification|regulation of transforming growth factor beta2 production|positive regulation of luteinizing hormone secretion|somatic stem cell population maintenance|intracellular signal transduction|atrioventricular canal development|endothelial cell activation|embryonic digit morphogenesis|identical protein binding|protein homodimerization activity|sulfate binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of follicle-stimulating hormone secretion|mesendoderm development|developmental growth|neuron fate commitment|sebaceous gland development|formation of anatomical boundary|regulation of binding|positive regulation of histone H3-K4 methylation|regulation of hair follicle development|uterus development|positive regulation of SMAD protein signal transduction|SMAD protein signal transduction|ventricular septum morphogenesis|negative regulation of cell death|endocardial cell differentiation|female gonad morphogenesis|secondary palate development|interleukin-6-mediated signaling pathway|negative regulation of ERK1 and ERK2 cascade|I-SMAD binding|R-SMAD binding|SMAD protein complex|heteromeric SMAD protein complex|response to transforming growth factor beta|cellular response to BMP stimulus|metanephric mesenchyme morphogenesis|nephrogenic mesenchyme morphogenesis|seminiferous tubule development|transcription regulator activator activity|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of cardiac myofibril assembly|positive regulation of histone H3-K9 acetylation" "hsa04068,hsa04110,hsa04310,hsa04350,hsa04371,hsa04390,hsa04520,hsa04550,hsa04659,hsa04933,hsa05161,hsa05166,hsa05200,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226" FoxO signaling pathway|Cell cycle|Wnt signaling pathway|TGF-beta signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Th17 cell differentiation|AGE-RAGE signaling pathway in diabetic complications|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer MH1 SMAD5 1687.195297 1780.232769 1594.157826 0.895477184 -0.159271421 0.627049056 1 11.8728614 11.08985461 4090 SMAD family member 5 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001657,GO:0001880,GO:0002051,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006468,GO:0007165,GO:0007179,GO:0007281,GO:0009653,GO:0009880,GO:0017151,GO:0030154,GO:0030218,GO:0030509,GO:0031625,GO:0032991,GO:0045669,GO:0045893,GO:0046872,GO:0051216,GO:0060048,GO:0060348,GO:0060395,GO:0070411,GO:0071141,GO:0071144,GO:0071407,GO:1901522,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|ureteric bud development|Mullerian duct regression|osteoblast fate commitment|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|protein phosphorylation|signal transduction|transforming growth factor beta receptor signaling pathway|germ cell development|anatomical structure morphogenesis|embryonic pattern specification|DEAD/H-box RNA helicase binding|cell differentiation|erythrocyte differentiation|BMP signaling pathway|ubiquitin protein ligase binding|protein-containing complex|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|metal ion binding|cartilage development|cardiac muscle contraction|bone development|SMAD protein signal transduction|I-SMAD binding|SMAD protein complex|heteromeric SMAD protein complex|cellular response to organic cyclic compound|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|sequence-specific double-stranded DNA binding" "hsa04350,hsa04550" TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells SMAD6 13.12019871 21.31407534 4.926322083 0.231129993 -2.113223609 0.109876771 1 0.141608648 0.034139882 4091 SMAD family member 6 "GO:0000785,GO:0000976,GO:0001657,GO:0003148,GO:0003180,GO:0003183,GO:0003184,GO:0003281,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006357,GO:0006955,GO:0007179,GO:0007352,GO:0008285,GO:0009653,GO:0010991,GO:0016604,GO:0030154,GO:0030279,GO:0030509,GO:0030512,GO:0030514,GO:0031589,GO:0031625,GO:0032496,GO:0032991,GO:0034616,GO:0034713,GO:0035904,GO:0042802,GO:0043066,GO:0043627,GO:0045444,GO:0045668,GO:0046872,GO:0060394,GO:0060395,GO:0060976,GO:0070410,GO:0070411,GO:0070412,GO:0070698,GO:0071144,GO:0140416,GO:1902895" chromatin|transcription regulatory region sequence-specific DNA binding|ureteric bud development|outflow tract septum morphogenesis|aortic valve morphogenesis|mitral valve morphogenesis|pulmonary valve morphogenesis|ventricular septum development|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|immune response|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis|negative regulation of cell population proliferation|anatomical structure morphogenesis|negative regulation of SMAD protein complex assembly|nuclear body|cell differentiation|negative regulation of ossification|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|cell-substrate adhesion|ubiquitin protein ligase binding|response to lipopolysaccharide|protein-containing complex|response to laminar fluid shear stress|type I transforming growth factor beta receptor binding|aorta development|identical protein binding|negative regulation of apoptotic process|response to estrogen|fat cell differentiation|negative regulation of osteoblast differentiation|metal ion binding|negative regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|coronary vasculature development|co-SMAD binding|I-SMAD binding|R-SMAD binding|type I activin receptor binding|heteromeric SMAD protein complex|transcription regulator inhibitor activity|positive regulation of pri-miRNA transcription by RNA polymerase II hsa04350 TGF-beta signaling pathway SMAD7 193.3748442 253.7389921 133.0106962 0.524202824 -0.931802969 0.08823029 1 3.47511758 1.900136452 4092 SMAD family member 7 "GO:0000122,GO:0000785,GO:0001650,GO:0001657,GO:0002725,GO:0003677,GO:0005515,GO:0005518,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005912,GO:0006357,GO:0007179,GO:0008013,GO:0009653,GO:0010717,GO:0010719,GO:0010801,GO:0010944,GO:0016342,GO:0016579,GO:0017015,GO:0022409,GO:0030154,GO:0030279,GO:0030336,GO:0030509,GO:0030512,GO:0030514,GO:0031397,GO:0031398,GO:0031625,GO:0032436,GO:0032925,GO:0032991,GO:0033137,GO:0034333,GO:0034616,GO:0034629,GO:0034713,GO:0043433,GO:0045944,GO:0046872,GO:0048185,GO:0048844,GO:0050821,GO:0051444,GO:0055010,GO:0055117,GO:0060373,GO:0060389,GO:0060394,GO:0060395,GO:0060412,GO:0070411,GO:0071144,GO:0071560,GO:0140416,GO:1902731,GO:1903043,GO:1990830,GO:2000317,GO:2000320" negative regulation of transcription by RNA polymerase II|chromatin|fibrillar center|ureteric bud development|negative regulation of T cell cytokine production|DNA binding|protein binding|collagen binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|plasma membrane|adherens junction|regulation of transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|beta-catenin binding|anatomical structure morphogenesis|regulation of epithelial to mesenchymal transition|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|negative regulation of transcription by competitive promoter binding|catenin complex|protein deubiquitination|regulation of transforming growth factor beta receptor signaling pathway|positive regulation of cell-cell adhesion|cell differentiation|negative regulation of ossification|negative regulation of cell migration|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of activin receptor signaling pathway|protein-containing complex|negative regulation of peptidyl-serine phosphorylation|adherens junction assembly|response to laminar fluid shear stress|cellular protein-containing complex localization|type I transforming growth factor beta receptor binding|negative regulation of DNA-binding transcription factor activity|positive regulation of transcription by RNA polymerase II|metal ion binding|activin binding|artery morphogenesis|protein stabilization|negative regulation of ubiquitin-protein transferase activity|ventricular cardiac muscle tissue morphogenesis|regulation of cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane depolarization|pathway-restricted SMAD protein phosphorylation|negative regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|ventricular septum morphogenesis|I-SMAD binding|heteromeric SMAD protein complex|cellular response to transforming growth factor beta stimulus|transcription regulator inhibitor activity|negative regulation of chondrocyte proliferation|positive regulation of chondrocyte hypertrophy|cellular response to leukemia inhibitory factor|negative regulation of T-helper 17 type immune response|negative regulation of T-helper 17 cell differentiation "hsa04350,hsa04390" TGF-beta signaling pathway|Hippo signaling pathway SMAD9 59.90269112 53.79266632 66.01271591 1.227169434 0.295334455 0.726186351 1 0.310650944 0.397642813 4093 SMAD family member 9 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007179,GO:0009653,GO:0030154,GO:0030509,GO:0046872,GO:0060395,GO:0070411,GO:0071141,GO:0071144,GO:0071773,GO:1901522" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|anatomical structure morphogenesis|cell differentiation|BMP signaling pathway|metal ion binding|SMAD protein signal transduction|I-SMAD binding|SMAD protein complex|heteromeric SMAD protein complex|cellular response to BMP stimulus|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" "hsa04350,hsa04550" TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells SMAGP 1072.686471 891.1313402 1254.241602 1.407471094 0.493105293 0.157019276 1 22.26574182 32.68831865 57228 small cell adhesion glycoprotein "GO:0005515,GO:0005654,GO:0005886,GO:0016021,GO:0030054,GO:0030659" protein binding|nucleoplasm|plasma membrane|integral component of membrane|cell junction|cytoplasmic vesicle membrane SMAP1 597.8553326 626.2278325 569.4828328 0.909386015 -0.137035278 0.728953685 1 6.736667484 6.390124389 60682 small ArfGAP 1 "GO:0005096,GO:0005737,GO:0005886,GO:0030276,GO:0043547,GO:0045648,GO:0046872,GO:2000369" GTPase activator activity|cytoplasm|plasma membrane|clathrin binding|positive regulation of GTPase activity|positive regulation of erythrocyte differentiation|metal ion binding|regulation of clathrin-dependent endocytosis hsa04144 Endocytosis SMAP2 623.2858933 714.5290017 532.0427849 0.744606284 -0.425450303 0.272472315 1 10.56903424 8.208767057 64744 small ArfGAP2 "GO:0005096,GO:0005515,GO:0005737,GO:0043547,GO:0046872" GTPase activator activity|protein binding|cytoplasm|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis SMARCA1 3420.08291 3046.897817 3793.268004 1.244960688 0.316100188 0.320497262 1 37.70208298 48.9594931 6594 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1" "GO:0000733,GO:0003677,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006338,GO:0007420,GO:0008094,GO:0008134,GO:0016589,GO:0030182,GO:0031491,GO:0036310,GO:0043044,GO:0043231,GO:0045893,GO:0045944,GO:0070615,GO:0090537" "DNA strand renaturation|DNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromatin remodeling|brain development|DNA-dependent ATPase activity|transcription factor binding|NURF complex|neuron differentiation|nucleosome binding|annealing helicase activity|ATP-dependent chromatin remodeling|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|nucleosome-dependent ATPase activity|CERF complex" SMARCA2 906.8475664 903.3108119 910.3843209 1.007830648 0.011253234 0.978388277 1 6.750701775 7.096634096 6595 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2" "GO:0000122,GO:0000785,GO:0000976,GO:0003677,GO:0003682,GO:0003713,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006338,GO:0006355,GO:0006357,GO:0007286,GO:0007399,GO:0008094,GO:0008285,GO:0016514,GO:0030308,GO:0042393,GO:0043044,GO:0043231,GO:0045111,GO:0045892,GO:0045893,GO:0045944,GO:0071564,GO:0071565" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|DNA binding|chromatin binding|transcription coactivator activity|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromatin remodeling|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spermatid development|nervous system development|DNA-dependent ATPase activity|negative regulation of cell population proliferation|SWI/SNF complex|negative regulation of cell growth|histone binding|ATP-dependent chromatin remodeling|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma SMARCA4 2697.197228 2865.220699 2529.173757 0.882715163 -0.179980114 0.572415845 1 23.94214164 22.04446242 6597 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4" "GO:0000122,GO:0000785,GO:0001164,GO:0001188,GO:0002039,GO:0003407,GO:0003677,GO:0003713,GO:0003714,GO:0003723,GO:0004386,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0006325,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0008094,GO:0008134,GO:0016020,GO:0016514,GO:0030177,GO:0030308,GO:0030957,GO:0031492,GO:0032991,GO:0038111,GO:0043044,GO:0043923,GO:0045892,GO:0045893,GO:0045944,GO:0047485,GO:0050681,GO:0051091,GO:0060766,GO:0070182,GO:0070577,GO:0071564,GO:0071565,GO:1901838,GO:1902661,GO:1902895,GO:1904837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I preinitiation complex assembly|p53 binding|neural retina development|DNA binding|transcription coactivator activity|transcription corepressor activity|RNA binding|helicase activity|protein binding|ATP binding|extracellular space|nucleus|nucleoplasm|nucleolus|chromatin organization|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|DNA-dependent ATPase activity|transcription factor binding|membrane|SWI/SNF complex|positive regulation of Wnt signaling pathway|negative regulation of cell growth|Tat protein binding|nucleosomal DNA binding|protein-containing complex|interleukin-7-mediated signaling pathway|ATP-dependent chromatin remodeling|positive regulation by host of viral transcription|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|androgen receptor binding|positive regulation of DNA-binding transcription factor activity|negative regulation of androgen receptor signaling pathway|DNA polymerase binding|lysine-acetylated histone binding|npBAF complex|nBAF complex|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|positive regulation of glucose mediated signaling pathway|positive regulation of pri-miRNA transcription by RNA polymerase II|beta-catenin-TCF complex assembly" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor SMARCA5 1997.194322 2159.826301 1834.562344 0.849402724 -0.235479359 0.465236758 1 14.23576037 12.61276338 8467 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5" "GO:0000183,GO:0000793,GO:0001650,GO:0003677,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005677,GO:0005829,GO:0006334,GO:0006338,GO:0006352,GO:0006357,GO:0008094,GO:0016584,GO:0016589,GO:0016887,GO:0031213,GO:0031491,GO:0034080,GO:0042393,GO:0043044,GO:0043231,GO:0043596,GO:0045815,GO:0045944,GO:1990830" "rDNA heterochromatin assembly|condensed chromosome|fibrillar center|DNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromatin silencing complex|cytosol|nucleosome assembly|chromatin remodeling|DNA-templated transcription, initiation|regulation of transcription by RNA polymerase II|DNA-dependent ATPase activity|nucleosome positioning|NURF complex|ATPase activity|RSF complex|nucleosome binding|CENP-A containing nucleosome assembly|histone binding|ATP-dependent chromatin remodeling|intracellular membrane-bounded organelle|nuclear replication fork|positive regulation of gene expression, epigenetic|positive regulation of transcription by RNA polymerase II|cellular response to leukemia inhibitory factor" SMARCAD1 894.653249 877.9369126 911.3695853 1.038080951 0.053918952 0.88369043 1 8.09916347 8.769752082 56916 "SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1" "GO:0000018,GO:0000729,GO:0000792,GO:0003677,GO:0003678,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006338,GO:0008094,GO:0032508,GO:0035861,GO:0043044,GO:0043130,GO:0043596,GO:0051304,GO:0070932,GO:0070933" regulation of DNA recombination|DNA double-strand break processing|heterochromatin|DNA binding|DNA helicase activity|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|chromatin remodeling|DNA-dependent ATPase activity|DNA duplex unwinding|site of double-strand break|ATP-dependent chromatin remodeling|ubiquitin binding|nuclear replication fork|chromosome separation|histone H3 deacetylation|histone H4 deacetylation hsa04550 Signaling pathways regulating pluripotency of stem cells SMARCAL1 717.2450331 705.394398 729.0956682 1.033600026 0.047678012 0.902645327 1 11.04350472 11.90626001 50485 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1" "GO:0000733,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005662,GO:0006259,GO:0006281,GO:0006303,GO:0006357,GO:0006974,GO:0008094,GO:0031297,GO:0032508,GO:0035861,GO:0036310,GO:0043596,GO:0048478,GO:0090656" DNA strand renaturation|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor A complex|DNA metabolic process|DNA repair|double-strand break repair via nonhomologous end joining|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|DNA-dependent ATPase activity|replication fork processing|DNA duplex unwinding|site of double-strand break|annealing helicase activity|nuclear replication fork|replication fork protection|t-circle formation SMARCB1 1874.755794 1939.580856 1809.930733 0.933155598 -0.099810433 0.759014677 1 19.02264289 18.51573049 6598 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1" "GO:0000228,GO:0000785,GO:0001164,GO:0001188,GO:0001650,GO:0002039,GO:0003677,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006337,GO:0006338,GO:0006357,GO:0007049,GO:0007399,GO:0015074,GO:0016514,GO:0030957,GO:0031492,GO:0032991,GO:0035060,GO:0039692,GO:0043044,GO:0043231,GO:0043923,GO:0045944,GO:0051091,GO:0071564,GO:0071565,GO:0090240,GO:1900110,GO:1900113,GO:1901838,GO:1902661,GO:2000617,GO:2000618" nuclear chromosome|chromatin|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I preinitiation complex assembly|fibrillar center|p53 binding|DNA binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleolus|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|cell cycle|nervous system development|DNA integration|SWI/SNF complex|Tat protein binding|nucleosomal DNA binding|protein-containing complex|brahma complex|single stranded viral RNA replication via double stranded DNA intermediate|ATP-dependent chromatin remodeling|intracellular membrane-bounded organelle|positive regulation by host of viral transcription|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|npBAF complex|nBAF complex|positive regulation of histone H4 acetylation|negative regulation of histone H3-K9 dimethylation|negative regulation of histone H3-K9 trimethylation|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|positive regulation of glucose mediated signaling pathway|positive regulation of histone H3-K9 acetylation|regulation of histone H4-K16 acetylation "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor SMARCC1 3612.95572 3232.634759 3993.27668 1.235300916 0.304862522 0.338193612 1 25.76668972 33.20070617 6599 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1" "GO:0000785,GO:0001741,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0008286,GO:0009887,GO:0016514,GO:0030850,GO:0031492,GO:0032435,GO:0032991,GO:0042393,GO:0043044,GO:0045893,GO:0045944,GO:0047485,GO:0071564,GO:0071565" "chromatin|XY body|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|insulin receptor signaling pathway|animal organ morphogenesis|SWI/SNF complex|prostate gland development|nucleosomal DNA binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|histone binding|ATP-dependent chromatin remodeling|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor SMARCC2 2990.153056 2450.103708 3530.202404 1.44083795 0.526908086 0.098212847 1 24.48482821 36.7983317 6601 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2" "GO:0000785,GO:0003713,GO:0005515,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0016514,GO:0031492,GO:0032991,GO:0042393,GO:0043044,GO:0045892,GO:0045893,GO:0071564,GO:0071565" "chromatin|transcription coactivator activity|protein binding|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|SWI/SNF complex|nucleosomal DNA binding|protein-containing complex|histone binding|ATP-dependent chromatin remodeling|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor SMARCD1 2105.538519 1854.324554 2356.752484 1.270949295 0.345906474 0.281640357 1 27.3565386 36.26647119 6602 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1" "GO:0001228,GO:0003682,GO:0003713,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0016514,GO:0043231,GO:0045944,GO:0048096,GO:0060090,GO:0071398,GO:0071564,GO:0071565" "DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|transcription coactivator activity|signaling receptor binding|protein binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|SWI/SNF complex|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|chromatin-mediated maintenance of transcription|molecular adaptor activity|cellular response to fatty acid|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma SMARCD2 1206.674021 1362.07091 1051.277132 0.771822616 -0.373658777 0.274355504 1 25.92412118 20.87072198 6603 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2" "GO:0000785,GO:0001228,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0016514,GO:0031492,GO:0032991,GO:0043044,GO:0045944" "chromatin|DNA-binding transcription activator activity, RNA polymerase II-specific|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|SWI/SNF complex|nucleosomal DNA binding|protein-containing complex|ATP-dependent chromatin remodeling|positive regulation of transcription by RNA polymerase II" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma SMARCD3 260.5685412 233.4398727 287.6972096 1.232425319 0.301500227 0.544927309 1 5.603272999 7.203081423 6604 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3" "GO:0000785,GO:0001228,GO:0002052,GO:0003139,GO:0003219,GO:0003407,GO:0003682,GO:0003713,GO:0005102,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0008134,GO:0010971,GO:0016514,GO:0019216,GO:0035257,GO:0042692,GO:0043393,GO:0045893,GO:0045944,GO:0051152,GO:0071564,GO:0071565" "chromatin|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of neuroblast proliferation|secondary heart field specification|cardiac right ventricle formation|neural retina development|chromatin binding|transcription coactivator activity|signaling receptor binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|transcription factor binding|positive regulation of G2/M transition of mitotic cell cycle|SWI/SNF complex|regulation of lipid metabolic process|nuclear hormone receptor binding|muscle cell differentiation|regulation of protein binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle cell differentiation|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma SMARCE1 2161.540485 2146.631873 2176.449096 1.013890236 0.019901474 0.952039365 1 21.11054981 22.32576837 6605 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1" "GO:0000228,GO:0000785,GO:0003682,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0008080,GO:0016514,GO:0016922,GO:0022008,GO:0031492,GO:0032991,GO:0043044,GO:0045892,GO:0045893,GO:0047485,GO:0071564,GO:0071565" "nuclear chromosome|chromatin|chromatin binding|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|N-acetyltransferase activity|SWI/SNF complex|nuclear receptor binding|neurogenesis|nucleosomal DNA binding|protein-containing complex|ATP-dependent chromatin remodeling|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein N-terminus binding|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor SMC1A 3959.700262 4810.89129 3108.509234 0.646139987 -0.630081335 0.048628692 1 24.72145617 16.66159588 8243 structural maintenance of chromosomes 1A "GO:0000070,GO:0000775,GO:0000776,GO:0000777,GO:0000794,GO:0003682,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006281,GO:0007062,GO:0007064,GO:0008278,GO:0009314,GO:0016363,GO:0019827,GO:0030893,GO:0036033,GO:0046982,GO:0051301,GO:0051321,GO:0072423,GO:0090307,GO:0097431" "mitotic sister chromatid segregation|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome|chromatin binding|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|cytosol|DNA repair|sister chromatid cohesion|mitotic sister chromatid cohesion|cohesin complex|response to radiation|nuclear matrix|stem cell population maintenance|meiotic cohesin complex|mediator complex binding|protein heterodimerization activity|cell division|meiotic cell cycle|response to DNA damage checkpoint signaling|mitotic spindle assembly|mitotic spindle pole" "hsa04110,hsa04114" Cell cycle|Oocyte meiosis other SMC1B 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.01187981 0.036087125 27127 structural maintenance of chromosomes 1B "GO:0000775,GO:0000800,GO:0003677,GO:0005524,GO:0005654,GO:0005829,GO:0007064,GO:0030893,GO:0034991,GO:0051321" "chromosome, centromeric region|lateral element|DNA binding|ATP binding|nucleoplasm|cytosol|mitotic sister chromatid cohesion|meiotic cohesin complex|nuclear meiotic cohesin complex|meiotic cell cycle" "hsa04110,hsa04114" Cell cycle|Oocyte meiosis SMC2 2382.303056 2285.680841 2478.925272 1.084545676 0.117090814 0.714674572 1 13.0966932 14.81581105 10592 structural maintenance of chromosomes 2 "GO:0000228,GO:0000793,GO:0000796,GO:0003682,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0007076,GO:0010032,GO:0045132,GO:0051301,GO:0051383,GO:0070062" nuclear chromosome|condensed chromosome|condensin complex|chromatin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|mitotic chromosome condensation|meiotic chromosome condensation|meiotic chromosome segregation|cell division|kinetochore organization|extracellular exosome SMC3 1740.855835 1676.70726 1805.004411 1.076517323 0.106371535 0.745364308 1 15.37836067 17.26819701 9126 structural maintenance of chromosomes 3 "GO:0000278,GO:0000775,GO:0000785,GO:0000800,GO:0003682,GO:0003777,GO:0005515,GO:0005524,GO:0005654,GO:0005694,GO:0005829,GO:0006275,GO:0006281,GO:0007062,GO:0008278,GO:0016363,GO:0019827,GO:0030893,GO:0034991,GO:0036033,GO:0046982,GO:0048487,GO:0051301,GO:0051321,GO:0070840,GO:0090307,GO:0097431" "mitotic cell cycle|chromosome, centromeric region|chromatin|lateral element|chromatin binding|microtubule motor activity|protein binding|ATP binding|nucleoplasm|chromosome|cytosol|regulation of DNA replication|DNA repair|sister chromatid cohesion|cohesin complex|nuclear matrix|stem cell population maintenance|meiotic cohesin complex|nuclear meiotic cohesin complex|mediator complex binding|protein heterodimerization activity|beta-tubulin binding|cell division|meiotic cell cycle|dynein complex binding|mitotic spindle assembly|mitotic spindle pole" "hsa04110,hsa04114" Cell cycle|Oocyte meiosis other SMC4 3803.279015 3378.788419 4227.769611 1.251267936 0.323390749 0.310001206 1 31.74248076 41.42925375 10051 structural maintenance of chromosomes 4 "GO:0000070,GO:0000775,GO:0000796,GO:0003682,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0007076,GO:0010032,GO:0016607,GO:0045132,GO:0051301,GO:0051383" "mitotic sister chromatid segregation|chromosome, centromeric region|condensin complex|chromatin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|mitotic chromosome condensation|meiotic chromosome condensation|nuclear speck|meiotic chromosome segregation|cell division|kinetochore organization" SMC5 1360.780311 1154.004936 1567.555687 1.358361336 0.4418673 0.188431851 1 10.02165276 14.19941957 23137 structural maintenance of chromosomes 5 "GO:0000722,GO:0000724,GO:0000775,GO:0000781,GO:0000803,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006303,GO:0006974,GO:0007062,GO:0016605,GO:0016607,GO:0018393,GO:0019827,GO:0030054,GO:0030261,GO:0030915,GO:0034184,GO:0035061,GO:0035861,GO:0044772,GO:0051301,GO:0051984,GO:0071459,GO:0090398" "telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, centromeric region|chromosome, telomeric region|sex chromosome|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|double-strand break repair via nonhomologous end joining|cellular response to DNA damage stimulus|sister chromatid cohesion|PML body|nuclear speck|internal peptidyl-lysine acetylation|stem cell population maintenance|cell junction|chromosome condensation|Smc5-Smc6 complex|positive regulation of maintenance of mitotic sister chromatid cohesion|interchromatin granule|site of double-strand break|mitotic cell cycle phase transition|cell division|positive regulation of chromosome segregation|protein localization to chromosome, centromeric region|cellular senescence" SMC6 739.9560952 641.452172 838.4600185 1.307127881 0.386400292 0.300838181 1 5.853565695 7.980948435 79677 structural maintenance of chromosomes 6 "GO:0000722,GO:0000775,GO:0000781,GO:0000803,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0006974,GO:0016605,GO:0016607,GO:0030915,GO:0031625,GO:0035061,GO:0035861,GO:0051984,GO:0090398,GO:0097431" "telomere maintenance via recombination|chromosome, centromeric region|chromosome, telomeric region|sex chromosome|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|PML body|nuclear speck|Smc5-Smc6 complex|ubiquitin protein ligase binding|interchromatin granule|site of double-strand break|positive regulation of chromosome segregation|cellular senescence|mitotic spindle pole" SMCHD1 2483.850118 2222.753571 2744.946664 1.234930719 0.304430107 0.340205549 1 10.23126665 13.17916596 23347 structural maintenance of chromosomes flexible hinge domain containing 1 "GO:0000781,GO:0001740,GO:0003677,GO:0005515,GO:0005524,GO:0006302,GO:0009048,GO:0016887,GO:0035861,GO:0042803,GO:0043584,GO:0045739,GO:0060820,GO:0060821,GO:0070868,GO:2000042,GO:2001034" "chromosome, telomeric region|Barr body|DNA binding|protein binding|ATP binding|double-strand break repair|dosage compensation by inactivation of X chromosome|ATPase activity|site of double-strand break|protein homodimerization activity|nose development|positive regulation of DNA repair|inactivation of X chromosome by heterochromatin assembly|inactivation of X chromosome by DNA methylation|heterochromatin organization involved in chromatin silencing|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining" SMCO2 1.970528833 0 3.941057666 Inf Inf 0.26888406 1 0 0.032485357 341346 single-pass membrane protein with coiled-coil domains 2 GO:0016021 integral component of membrane SMCO4 101.147463 78.15160956 124.1433165 1.588493406 0.667659102 0.324473598 1 0.836631436 1.386230739 56935 single-pass membrane protein with coiled-coil domains 4 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane SMCR8 1860.717879 1821.845963 1899.589795 1.042673109 0.060286926 0.853833696 1 11.12089562 12.09494415 140775 SMCR8-C9orf72 complex subunit "GO:0000785,GO:0004860,GO:0005085,GO:0005515,GO:0005654,GO:0005737,GO:0006469,GO:0006914,GO:0010506,GO:0010629,GO:0016242,GO:0019901,GO:0032008,GO:0032045,GO:1901098,GO:1902902,GO:1903432,GO:1990316" chromatin|protein kinase inhibitor activity|guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|cytoplasm|negative regulation of protein kinase activity|autophagy|regulation of autophagy|negative regulation of gene expression|negative regulation of macroautophagy|protein kinase binding|positive regulation of TOR signaling|guanyl-nucleotide exchange factor complex|positive regulation of autophagosome maturation|negative regulation of autophagosome assembly|regulation of TORC1 signaling|Atg1/ULK1 kinase complex "hsa04140,hsa05014,hsa05022" Autophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases SMDT1 384.5201003 388.7281359 380.3120648 0.978349725 -0.031577826 0.948905949 1 12.60416692 12.86246491 91689 single-pass membrane protein with aspartate rich tail 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005759,GO:0006851,GO:0031305,GO:0036444,GO:0051560,GO:1990246" protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial calcium ion transmembrane transport|integral component of mitochondrial inner membrane|calcium import into the mitochondrion|mitochondrial calcium ion homeostasis|uniplex complex SMG1 4011.98707 4344.011545 3679.962596 0.847134626 -0.239336835 0.452837793 1 13.26633261 11.7224731 23049 SMG1 nonsense mediated mRNA decay associated PI3K related kinase "GO:0000184,GO:0003723,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006406,GO:0016242,GO:0018105,GO:0031931,GO:0031932,GO:0032204,GO:0038202,GO:0042162,GO:0046777,GO:0046854,GO:0046872,GO:0106310,GO:0106311,GO:2001020" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|mRNA export from nucleus|negative regulation of macroautophagy|peptidyl-serine phosphorylation|TORC1 complex|TORC2 complex|regulation of telomere maintenance|TORC1 signaling|telomeric DNA binding|protein autophosphorylation|phosphatidylinositol phosphorylation|metal ion binding|protein serine kinase activity|protein threonine kinase activity|regulation of response to DNA damage stimulus" hsa03015 mRNA surveillance pathway SMG5 4440.494944 4068.958477 4812.03141 1.182619935 0.241986502 0.449081634 1 41.54806299 51.25212854 23381 SMG5 nonsense mediated mRNA decay factor "GO:0000184,GO:0005515,GO:0005634,GO:0005697,GO:0005737,GO:0005829,GO:0006406,GO:0031625,GO:0032204,GO:0032210,GO:0035303,GO:0042162,GO:0042826,GO:0051721,GO:0070034" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein binding|nucleus|telomerase holoenzyme complex|cytoplasm|cytosol|mRNA export from nucleus|ubiquitin protein ligase binding|regulation of telomere maintenance|regulation of telomere maintenance via telomerase|regulation of dephosphorylation|telomeric DNA binding|histone deacetylase binding|protein phosphatase 2A binding|telomerase RNA binding" hsa03015 mRNA surveillance pathway SMG6 1522.377038 1356.99613 1687.757946 1.243745585 0.314691405 0.341798266 1 5.184600692 6.726091878 23293 SMG6 nonsense mediated mRNA decay factor "GO:0000184,GO:0000781,GO:0003723,GO:0004521,GO:0005515,GO:0005634,GO:0005697,GO:0005730,GO:0005737,GO:0005829,GO:0006406,GO:0032204,GO:0032210,GO:0035145,GO:0035303,GO:0042162,GO:0043021,GO:0046872,GO:0051972,GO:0070034,GO:0070182,GO:0090502,GO:1904354" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|chromosome, telomeric region|RNA binding|endoribonuclease activity|protein binding|nucleus|telomerase holoenzyme complex|nucleolus|cytoplasm|cytosol|mRNA export from nucleus|regulation of telomere maintenance|regulation of telomere maintenance via telomerase|exon-exon junction complex|regulation of dephosphorylation|telomeric DNA binding|ribonucleoprotein complex binding|metal ion binding|regulation of telomerase activity|telomerase RNA binding|DNA polymerase binding|RNA phosphodiester bond hydrolysis, endonucleolytic|negative regulation of telomere capping" hsa03015 mRNA surveillance pathway SMG7 2010.41176 2086.749471 1934.07405 0.926835769 -0.109614373 0.734572895 1 14.85404063 14.36029373 9887 SMG7 nonsense mediated mRNA decay factor "GO:0000184,GO:0005515,GO:0005634,GO:0005697,GO:0005737,GO:0005829,GO:0006406,GO:0035303,GO:0042162,GO:0045111,GO:0051721,GO:0070034" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein binding|nucleus|telomerase holoenzyme complex|cytoplasm|cytosol|mRNA export from nucleus|regulation of dephosphorylation|telomeric DNA binding|intermediate filament cytoskeleton|protein phosphatase 2A binding|telomerase RNA binding" hsa03015 mRNA surveillance pathway SMG8 716.9602418 719.6037816 714.316702 0.992652791 -0.010638914 0.98156495 1 11.31493105 11.71561819 55181 SMG8 nonsense mediated mRNA decay factor "GO:0000184,GO:0005515,GO:0005575,GO:0005829,GO:0045859" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein binding|cellular_component|cytosol|regulation of protein kinase activity" SMG9 942.2374133 965.2231259 919.2517006 0.95237223 -0.070402541 0.845840337 1 8.537398922 8.481022745 56006 SMG9 nonsense mediated mRNA decay factor "GO:0000184,GO:0001654,GO:0001701,GO:0005515,GO:0005829,GO:0007420,GO:0007507,GO:0042802" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|eye development|in utero embryonic development|protein binding|cytosol|brain development|heart development|identical protein binding" SMIM1 18.01682924 19.2841634 16.74949508 0.868562184 -0.203298953 0.907139997 1 1.930187442 1.748704117 388588 small integral membrane protein 1 (Vel blood group) "GO:0005515,GO:0005886,GO:0009986,GO:0016021,GO:0042803" protein binding|plasma membrane|cell surface|integral component of membrane|protein homodimerization activity SMIM10 104.2935298 124.8395841 83.74747541 0.670840711 -0.57595785 0.391093362 1 4.263442028 2.983291581 644538 small integral membrane protein 10 GO:0016021 integral component of membrane SMIM10L1 679.3447662 673.930763 684.7587695 1.016066942 0.022995455 0.955924187 1 7.076967792 7.500418054 100129361 small integral membrane protein 10 like 1 SMIM10L2A 13.01627828 14.20938356 11.823173 0.832067975 -0.265226703 0.893085452 1 0.137601367 0.119425615 399668 small integral membrane protein 10 like 2A SMIM10L2B 7.47855778 6.08973581 8.867379749 1.456118956 0.542128219 0.797747104 1 0.109486559 0.166292855 644596 small integral membrane protein 10 like 2B SMIM11A 79.42166533 142.0938356 16.74949508 0.117876296 -3.084654457 0.000121813 0.018805381 8.567323208 1.053386051 54065 small integral membrane protein 11A "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane SMIM11B 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.03764937 0 102723553 small integral membrane protein 11B SMIM12 624.9501041 626.2278325 623.6723757 0.995919286 -0.005899271 0.992549851 1 3.79835096 3.945800853 113444 small integral membrane protein 12 "GO:0005515,GO:0016021" protein binding|integral component of membrane SMIM13 594.6822959 544.016399 645.3481928 1.186266065 0.246427625 0.530699812 1 5.637919263 6.976167327 221710 small integral membrane protein 13 GO:0016021 integral component of membrane SMIM14 459.1775094 373.5037964 544.8512224 1.458756852 0.544739433 0.19238068 1 2.894667122 4.40450865 201895 small integral membrane protein 14 "GO:0001835,GO:0005515,GO:0005783,GO:0005789,GO:0016021" blastocyst hatching|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane SMIM15 1072.709236 1162.124584 983.2938877 0.846117449 -0.241070159 0.489352649 1 20.38002439 17.98669127 643155 small integral membrane protein 15 GO:0016021 integral component of membrane SMIM19 102.0409312 105.5554207 98.52644165 0.933409587 -0.09941781 0.896711158 1 1.731220752 1.685546105 114926 small integral membrane protein 19 "GO:0005515,GO:0016021" protein binding|integral component of membrane SMIM20 181.0199448 183.7070303 178.3328594 0.970745971 -0.042834281 0.949235722 1 9.407596566 9.52577263 389203 small integral membrane protein 20 "GO:0005515,GO:0005576,GO:0005743,GO:0016021,GO:0033617" protein binding|extracellular region|mitochondrial inner membrane|integral component of membrane|mitochondrial cytochrome c oxidase assembly SMIM26 949.0006522 956.0885222 941.9127822 0.985173193 -0.021550723 0.954846622 1 89.5055652 91.97685491 388789 small integral membrane protein 26 GO:0016021 integral component of membrane SMIM27 61.49935395 61.91231407 61.08639383 0.986659839 -0.019375308 1 1 2.440186999 2.511345642 100129250 small integral membrane protein 27 GO:0016021 integral component of membrane SMIM29 413.1521515 392.7879598 433.5163433 1.103690509 0.142335676 0.744371376 1 18.59189205 21.40360003 221491 small integral membrane protein 29 GO:0016021 integral component of membrane SMIM3 173.5441087 144.1237475 202.9644698 1.408265281 0.493919126 0.383251026 1 4.799052842 7.049461357 85027 small integral membrane protein 3 "GO:0005515,GO:0016021,GO:0042802" protein binding|integral component of membrane|identical protein binding SMIM30 607.7673599 630.2876564 585.2470634 0.928539624 -0.106964619 0.786970647 1 29.04626594 28.1323933 401397 small integral membrane protein 30 GO:0016021 integral component of membrane SMIM38 5.04508829 8.119647747 1.970528833 0.242686493 -2.042834281 0.307402201 1 0.174398437 0.044147297 107984345 small integral membrane protein 38 GO:0016021 integral component of membrane SMIM4 184.7801316 205.0211056 164.5391576 0.802547411 -0.317341472 0.56993779 1 5.508538848 4.611296466 440957 small integral membrane protein 4 GO:0016021 integral component of membrane SMIM7 705.7336214 726.7084734 684.7587695 0.942274371 -0.085780891 0.823118775 1 18.72086496 18.40005914 79086 small integral membrane protein 7 GO:0016021 integral component of membrane SMIM8 65.02200829 66.98709391 63.05692266 0.941329426 -0.087228401 0.931301585 1 1.391575058 1.366357046 57150 small integral membrane protein 8 GO:0016021 integral component of membrane SMKR1 8.5232053 10.14955968 6.896850916 0.679522179 -0.557407454 0.765908482 1 0.530484409 0.376003763 100287482 small lysine rich protein 1 SMN1 378.5652143 554.1659587 202.9644698 0.366252143 -1.449090895 0.001216846 0.103730371 15.20398203 5.808359005 6606 "survival of motor neuron 1, telomeric" "GO:0000245,GO:0000387,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006353,GO:0007399,GO:0015030,GO:0016604,GO:0030018,GO:0030424,GO:0032797,GO:0034719,GO:0036464,GO:0042802,GO:0043005,GO:0043204,GO:0051170,GO:0097504" "spliceosomal complex assembly|spliceosomal snRNP assembly|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA-templated transcription, termination|nervous system development|Cajal body|nuclear body|Z disc|axon|SMN complex|SMN-Sm protein complex|cytoplasmic ribonucleoprotein granule|identical protein binding|neuron projection|perikaryon|import into nucleus|Gemini of coiled bodies" hsa03013 RNA transport SMN2 235.2782734 255.768904 214.7876428 0.839772308 -0.25192988 0.62618691 1 7.017222476 6.146710015 6607 "survival of motor neuron 2, centromeric" "GO:0000245,GO:0000387,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006353,GO:0007399,GO:0015030,GO:0016604,GO:0030018,GO:0030424,GO:0032797,GO:0034719,GO:0036464,GO:0042802,GO:0043005,GO:0043204,GO:0051170,GO:0097504" "spliceosomal complex assembly|spliceosomal snRNP assembly|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA-templated transcription, termination|nervous system development|Cajal body|nuclear body|Z disc|axon|SMN complex|SMN-Sm protein complex|cytoplasmic ribonucleoprotein granule|identical protein binding|neuron projection|perikaryon|import into nucleus|Gemini of coiled bodies" hsa03013 RNA transport SMNDC1 527.568271 502.4032043 552.7333377 1.100178767 0.137737964 0.735784368 1 5.593526034 6.418962704 10285 survival motor neuron domain containing 1 "GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006915,GO:0015030,GO:0016607" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|apoptotic process|Cajal body|nuclear speck" hsa03040 Spliceosome SMO 552.1108068 496.3134685 607.908145 1.224847165 0.292601743 0.464086721 1 5.250997763 6.708719972 6608 "smoothened, frizzled class receptor" "GO:0000122,GO:0001570,GO:0001649,GO:0001701,GO:0001708,GO:0001755,GO:0001947,GO:0002052,GO:0002053,GO:0003140,GO:0003323,GO:0004930,GO:0005113,GO:0005515,GO:0005794,GO:0005886,GO:0005901,GO:0005929,GO:0007186,GO:0007224,GO:0007228,GO:0007371,GO:0007417,GO:0007494,GO:0009952,GO:0010628,GO:0010629,GO:0016021,GO:0021542,GO:0021696,GO:0021794,GO:0021904,GO:0021910,GO:0021938,GO:0021953,GO:0021987,GO:0030335,GO:0030425,GO:0030666,GO:0030857,GO:0031069,GO:0034504,GO:0035264,GO:0040018,GO:0042307,GO:0042475,GO:0043066,GO:0043231,GO:0043392,GO:0045880,GO:0045944,GO:0046622,GO:0048143,GO:0048741,GO:0048745,GO:0048853,GO:0048873,GO:0050679,GO:0050821,GO:0051451,GO:0051799,GO:0060170,GO:0060242,GO:0060413,GO:0060644,GO:0060684,GO:0061053,GO:0061113,GO:0070062,GO:0070986,GO:0071397,GO:0071679,GO:0072285,GO:0090190,GO:0097542,GO:0097731,GO:2000036,GO:2000826" negative regulation of transcription by RNA polymerase II|vasculogenesis|osteoblast differentiation|in utero embryonic development|cell fate specification|neural crest cell migration|heart looping|positive regulation of neuroblast proliferation|positive regulation of mesenchymal cell proliferation|determination of left/right asymmetry in lateral mesoderm|type B pancreatic cell development|G protein-coupled receptor activity|patched binding|protein binding|Golgi apparatus|plasma membrane|caveola|cilium|G protein-coupled receptor signaling pathway|smoothened signaling pathway|positive regulation of hh target transcription factor activity|ventral midline determination|central nervous system development|midgut development|anterior/posterior pattern specification|positive regulation of gene expression|negative regulation of gene expression|integral component of membrane|dentate gyrus development|cerebellar cortex morphogenesis|thalamus development|dorsal/ventral neural tube patterning|smoothened signaling pathway involved in ventral spinal cord patterning|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|central nervous system neuron differentiation|cerebral cortex development|positive regulation of cell migration|dendrite|endocytic vesicle membrane|negative regulation of epithelial cell differentiation|hair follicle morphogenesis|protein localization to nucleus|multicellular organism growth|positive regulation of multicellular organism growth|positive regulation of protein import into nucleus|odontogenesis of dentin-containing tooth|negative regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of DNA binding|positive regulation of smoothened signaling pathway|positive regulation of transcription by RNA polymerase II|positive regulation of organ growth|astrocyte activation|skeletal muscle fiber development|smooth muscle tissue development|forebrain morphogenesis|homeostasis of number of cells within a tissue|positive regulation of epithelial cell proliferation|protein stabilization|myoblast migration|negative regulation of hair follicle development|ciliary membrane|contact inhibition|atrial septum morphogenesis|mammary gland epithelial cell differentiation|epithelial-mesenchymal cell signaling|somite development|pancreas morphogenesis|extracellular exosome|left/right axis specification|cellular response to cholesterol|commissural neuron axon guidance|mesenchymal to epithelial transition involved in metanephric renal vesicle formation|positive regulation of branching involved in ureteric bud morphogenesis|ciliary tip|9+0 non-motile cilium|regulation of stem cell population maintenance|regulation of heart morphogenesis "hsa04340,hsa04360,hsa05200,hsa05205,hsa05217" Hedgehog signaling pathway|Axon guidance|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma SMOC1 13.58313937 19.2841634 7.882115332 0.408735145 -1.290761795 0.314396824 1 0.261143007 0.111336179 64093 SPARC related modular calcium binding 1 "GO:0001654,GO:0005509,GO:0005515,GO:0005604,GO:0005615,GO:0008201,GO:0030154,GO:0030198,GO:0045667,GO:0050840,GO:0060173" eye development|calcium ion binding|protein binding|basement membrane|extracellular space|heparin binding|cell differentiation|extracellular matrix organization|regulation of osteoblast differentiation|extracellular matrix binding|limb development SMOX 1569.507418 1884.773233 1254.241602 0.665460216 -0.587575677 0.075194585 1 39.009855 27.07773678 54498 spermine oxidase "GO:0005654,GO:0005829,GO:0006596,GO:0006598,GO:0016491,GO:0031965,GO:0043231,GO:0046208,GO:0046592,GO:0052894,GO:0052895,GO:0052901,GO:0055114" nucleoplasm|cytosol|polyamine biosynthetic process|polyamine catabolic process|oxidoreductase activity|nuclear membrane|intracellular membrane-bounded organelle|spermine catabolic process|polyamine oxidase activity|norspermine:oxygen oxidoreductase activity|N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity|spermine:oxygen oxidoreductase (spermidine-forming) activity|oxidation-reduction process "hsa00330,hsa00410" Arginine and proline metabolism|beta-Alanine metabolism SMPD1 346.4389625 378.5785762 314.2993489 0.83020902 -0.268453488 0.55515106 1 7.762619166 6.722203531 6609 sphingomyelin phosphodiesterase 1 "GO:0001778,GO:0004767,GO:0005515,GO:0005615,GO:0005764,GO:0005768,GO:0005886,GO:0006684,GO:0006685,GO:0006687,GO:0007165,GO:0007399,GO:0008081,GO:0008203,GO:0008270,GO:0009615,GO:0010212,GO:0016798,GO:0023021,GO:0034340,GO:0034612,GO:0034644,GO:0035307,GO:0036019,GO:0042060,GO:0042220,GO:0042493,GO:0042599,GO:0043065,GO:0043202,GO:0043407,GO:0045807,GO:0046513,GO:0046718,GO:0061750,GO:0070062,GO:0070555,GO:0071277" "plasma membrane repair|sphingomyelin phosphodiesterase activity|protein binding|extracellular space|lysosome|endosome|plasma membrane|sphingomyelin metabolic process|sphingomyelin catabolic process|glycosphingolipid metabolic process|signal transduction|nervous system development|phosphoric diester hydrolase activity|cholesterol metabolic process|zinc ion binding|response to virus|response to ionizing radiation|hydrolase activity, acting on glycosyl bonds|termination of signal transduction|response to type I interferon|response to tumor necrosis factor|cellular response to UV|positive regulation of protein dephosphorylation|endolysosome|wound healing|response to cocaine|response to drug|lamellar body|positive regulation of apoptotic process|lysosomal lumen|negative regulation of MAP kinase activity|positive regulation of endocytosis|ceramide biosynthetic process|viral entry into host cell|acid sphingomyelin phosphodiesterase activity|extracellular exosome|response to interleukin-1|cellular response to calcium ion" "hsa00600,hsa04071,hsa04142,hsa04217" Sphingolipid metabolism|Sphingolipid signaling pathway|Lysosome|Necroptosis SMPD2 180.390979 208.0659735 152.7159846 0.733978661 -0.446189975 0.425343287 1 6.184159358 4.73456448 6610 sphingomyelin phosphodiesterase 2 "GO:0004620,GO:0004767,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0005901,GO:0006684,GO:0006685,GO:0006687,GO:0009612,GO:0016020,GO:0030149,GO:0035556,GO:0046513,GO:0046872,GO:0071944,GO:2000304" phospholipase activity|sphingomyelin phosphodiesterase activity|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|caveola|sphingomyelin metabolic process|sphingomyelin catabolic process|glycosphingolipid metabolic process|response to mechanical stimulus|membrane|sphingolipid catabolic process|intracellular signal transduction|ceramide biosynthetic process|metal ion binding|cell periphery|positive regulation of ceramide biosynthetic process "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SMPD4 2603.17227 2398.340953 2808.003587 1.17081084 0.227508009 0.475618717 1 20.79567 25.39660017 55627 sphingomyelin phosphodiesterase 4 "GO:0000139,GO:0004767,GO:0005635,GO:0005640,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0006685,GO:0006687,GO:0007029,GO:0016021,GO:0042383,GO:0046475,GO:0046513,GO:0046872,GO:0050290,GO:0071356" Golgi membrane|sphingomyelin phosphodiesterase activity|nuclear envelope|nuclear outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|sphingomyelin catabolic process|glycosphingolipid metabolic process|endoplasmic reticulum organization|integral component of membrane|sarcolemma|glycerophospholipid catabolic process|ceramide biosynthetic process|metal ion binding|sphingomyelin phosphodiesterase D activity|cellular response to tumor necrosis factor hsa00600 Sphingolipid metabolism SMPDL3A 36.48175336 35.52345889 37.44004783 1.053952768 0.075810215 0.967396769 1 0.671570688 0.738293102 10924 sphingomyelin phosphodiesterase acid like 3A "GO:0004767,GO:0005515,GO:0005615,GO:0006685,GO:0008081,GO:0008270,GO:0009143,GO:0070062" sphingomyelin phosphodiesterase activity|protein binding|extracellular space|sphingomyelin catabolic process|phosphoric diester hydrolase activity|zinc ion binding|nucleoside triphosphate catabolic process|extracellular exosome SMPDL3B 37.57093821 42.62815067 32.51372575 0.762728977 -0.390757585 0.68943602 1 0.720375525 0.57311942 27293 sphingomyelin phosphodiesterase acid like 3B "GO:0004767,GO:0005615,GO:0005886,GO:0006685,GO:0006954,GO:0008081,GO:0008150,GO:0008270,GO:0016798,GO:0031225,GO:0034122,GO:0045087,GO:0046466,GO:0050728,GO:0070062" "sphingomyelin phosphodiesterase activity|extracellular space|plasma membrane|sphingomyelin catabolic process|inflammatory response|phosphoric diester hydrolase activity|biological_process|zinc ion binding|hydrolase activity, acting on glycosyl bonds|anchored component of membrane|negative regulation of toll-like receptor signaling pathway|innate immune response|membrane lipid catabolic process|negative regulation of inflammatory response|extracellular exosome" SMS 3801.467338 3995.881647 3607.053029 0.902692659 -0.14769322 0.643067973 1 86.78272248 81.71261528 6611 spermine synthase "GO:0005829,GO:0006555,GO:0006595,GO:0006597,GO:0016768,GO:0070062" cytosol|methionine metabolic process|polyamine metabolic process|spermine biosynthetic process|spermine synthase activity|extracellular exosome "hsa00270,hsa00330,hsa00480" Cysteine and methionine metabolism|Arginine and proline metabolism|Glutathione metabolism SMTN 1434.699391 1223.021942 1646.37684 1.346154786 0.428844306 0.19856732 1 11.35920535 15.94993362 6525 smoothelin "GO:0003779,GO:0005737,GO:0005815,GO:0005856,GO:0006939,GO:0007517,GO:0008307,GO:0015629,GO:0030036,GO:0031941" actin binding|cytoplasm|microtubule organizing center|cytoskeleton|smooth muscle contraction|muscle organ development|structural constituent of muscle|actin cytoskeleton|actin cytoskeleton organization|filamentous actin SMU1 1957.132015 1913.192 2001.07203 1.045933722 0.064791435 0.842206532 1 13.51980263 14.74994656 55234 SMU1 DNA replication regulator and spliceosomal factor "GO:0000381,GO:0000398,GO:0005515,GO:0005634,GO:0005737,GO:0008380,GO:0016032,GO:0016607,GO:0071005,GO:0071011" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|protein binding|nucleus|cytoplasm|RNA splicing|viral process|nuclear speck|U2-type precatalytic spliceosome|precatalytic spliceosome" SMUG1 868.736737 891.1313402 846.3421338 0.949738939 -0.07439709 0.839655173 1 13.41636702 13.29092186 23583 single-strand-selective monofunctional uracil-DNA glycosylase 1 "GO:0000703,GO:0001650,GO:0003677,GO:0004844,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006284,GO:0017065,GO:0019104,GO:0045008" oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|fibrillar center|DNA binding|uracil DNA N-glycosylase activity|protein binding|nucleoplasm|nucleolus|cytosol|base-excision repair|single-strand selective uracil DNA N-glycosylase activity|DNA N-glycosylase activity|depyrimidination hsa03410 Base excision repair SMURF1 2267.051368 2354.697847 2179.404889 0.925556072 -0.111607701 0.728048912 1 20.73676562 20.01979762 57154 SMAD specific E3 ubiquitin protein ligase 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005543,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006511,GO:0006611,GO:0007179,GO:0007398,GO:0016567,GO:0030154,GO:0030424,GO:0030509,GO:0030512,GO:0030514,GO:0030579,GO:0032801,GO:0034394,GO:0043025,GO:0043161,GO:0045732,GO:0048185,GO:0060071,GO:0061630,GO:0061736,GO:0061753,GO:0070062,GO:0070411,GO:0070412,GO:0071211,GO:0072659,GO:1903861,GO:2000060" "protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|phospholipid binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|protein export from nucleus|transforming growth factor beta receptor signaling pathway|ectoderm development|protein ubiquitination|cell differentiation|axon|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|ubiquitin-dependent SMAD protein catabolic process|receptor catabolic process|protein localization to cell surface|neuronal cell body|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|activin binding|Wnt signaling pathway, planar cell polarity pathway|ubiquitin protein ligase activity|engulfment of target by autophagosome|substrate localization to autophagosome|extracellular exosome|I-SMAD binding|R-SMAD binding|protein targeting to vacuole involved in autophagy|protein localization to plasma membrane|positive regulation of dendrite extension|positive regulation of ubiquitin-dependent protein catabolic process" "hsa04120,hsa04144,hsa04340,hsa04350" Ubiquitin mediated proteolysis|Endocytosis|Hedgehog signaling pathway|TGF-beta signaling pathway SMURF2 3974.211751 3142.303678 4806.119824 1.529489291 0.613050005 0.055022452 1 27.25112944 43.47572938 64750 SMAD specific E3 ubiquitin protein ligase 2 "GO:0000122,GO:0000151,GO:0000209,GO:0004842,GO:0005160,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006511,GO:0016567,GO:0016579,GO:0016607,GO:0017015,GO:0030509,GO:0030512,GO:0030514,GO:0030579,GO:0042802,GO:0043161,GO:0045121,GO:0045732,GO:0045892,GO:0046332,GO:0060071,GO:0061630,GO:0090263,GO:1901165" "negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|transforming growth factor beta receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|protein ubiquitination|protein deubiquitination|nuclear speck|regulation of transforming growth factor beta receptor signaling pathway|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|ubiquitin-dependent SMAD protein catabolic process|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|membrane raft|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|SMAD binding|Wnt signaling pathway, planar cell polarity pathway|ubiquitin protein ligase activity|positive regulation of canonical Wnt signaling pathway|positive regulation of trophoblast cell migration" "hsa04120,hsa04144,hsa04340,hsa04350" Ubiquitin mediated proteolysis|Endocytosis|Hedgehog signaling pathway|TGF-beta signaling pathway SMYD2 957.7128932 844.4433657 1070.982421 1.268270276 0.342862226 0.334471227 1 24.50892691 32.42291372 56950 SET and MYND domain containing 2 "GO:0000122,GO:0000993,GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007507,GO:0008285,GO:0010452,GO:0016278,GO:0016279,GO:0018024,GO:0018026,GO:0018027,GO:0034968,GO:0043516,GO:0046872,GO:0046975,GO:1901796" "negative regulation of transcription by RNA polymerase II|RNA polymerase II complex binding|p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|heart development|negative regulation of cell population proliferation|histone H3-K36 methylation|lysine N-methyltransferase activity|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|histone lysine methylation|regulation of DNA damage response, signal transduction by p53 class mediator|metal ion binding|histone methyltransferase activity (H3-K36 specific)|regulation of signal transduction by p53 class mediator" hsa00310 Lysine degradation SMYD3 425.3261799 484.1339969 366.518363 0.757059751 -0.401520926 0.346774196 1 3.055411716 2.412769458 64754 SET and MYND domain containing 3 "GO:0000978,GO:0000993,GO:0001162,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0006469,GO:0014904,GO:0018024,GO:0033138,GO:0034968,GO:0045184,GO:0045944,GO:0046872,GO:0071549" RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II complex binding|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|negative regulation of protein kinase activity|myotube cell development|histone-lysine N-methyltransferase activity|positive regulation of peptidyl-serine phosphorylation|histone lysine methylation|establishment of protein localization|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to dexamethasone stimulus hsa00310 Lysine degradation SMYD4 599.6801253 582.5847258 616.7755248 1.058688114 0.082277639 0.836986531 1 6.300632314 6.957738518 114826 SET and MYND domain containing 4 "GO:0008168,GO:0032259,GO:0046872" methyltransferase activity|methylation|metal ion binding SMYD5 612.272557 668.8559832 555.6891309 0.830805353 -0.267417584 0.493002923 1 13.26358495 11.4941309 10322 SMYD family member 5 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0008168,GO:0032259,GO:0046872" molecular_function|protein binding|cellular_component|biological_process|methyltransferase activity|methylation|metal ion binding SNAI1 5.04508829 8.119647747 1.970528833 0.242686493 -2.042834281 0.307402201 1 0.241191504 0.061055324 6615 snail family transcriptional repressor 1 "GO:0000122,GO:0000977,GO:0000978,GO:0001227,GO:0001649,GO:0001650,GO:0001707,GO:0001837,GO:0003180,GO:0003198,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0005737,GO:0005829,GO:0006357,GO:0010718,GO:0010957,GO:0016477,GO:0019900,GO:0030335,GO:0031069,GO:0043231,GO:0043518,GO:0045893,GO:0046872,GO:0060021,GO:0060536,GO:0060707,GO:0060806,GO:0060972,GO:0061314,GO:0070828,GO:0070888,GO:1902230,GO:1990837,GO:2000810" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|osteoblast differentiation|fibrillar center|mesoderm formation|epithelial to mesenchymal transition|aortic valve morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|positive regulation of epithelial to mesenchymal transition|negative regulation of vitamin D biosynthetic process|cell migration|kinase binding|positive regulation of cell migration|hair follicle morphogenesis|intracellular membrane-bounded organelle|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of transcription, DNA-templated|metal ion binding|roof of mouth development|cartilage morphogenesis|trophoblast giant cell differentiation|negative regulation of cell differentiation involved in embryonic placenta development|left/right pattern formation|Notch signaling involved in heart development|heterochromatin organization|E-box binding|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|sequence-specific double-stranded DNA binding|regulation of bicellular tight junction assembly" hsa04520 Adherens junction zf-C2H2 SNAI2 850.9062219 783.5460076 918.2664362 1.171936845 0.228894826 0.529227072 1 18.20359683 22.25242503 6591 snail family transcriptional repressor 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001649,GO:0001837,GO:0003180,GO:0003198,GO:0003273,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0007219,GO:0007605,GO:0010839,GO:0010957,GO:0014032,GO:0030335,GO:0032331,GO:0032642,GO:0033629,GO:0035921,GO:0043473,GO:0043518,GO:0043565,GO:0045667,GO:0046872,GO:0060429,GO:0061314,GO:0070563,GO:0070888,GO:0071364,GO:0090090,GO:1902230,GO:1990837,GO:2000810,GO:2000811,GO:2001240" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|osteoblast differentiation|epithelial to mesenchymal transition|aortic valve morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|cell migration involved in endocardial cushion formation|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|Notch signaling pathway|sensory perception of sound|negative regulation of keratinocyte proliferation|negative regulation of vitamin D biosynthetic process|neural crest cell development|positive regulation of cell migration|negative regulation of chondrocyte differentiation|regulation of chemokine production|negative regulation of cell adhesion mediated by integrin|desmosome disassembly|pigmentation|negative regulation of DNA damage response, signal transduction by p53 class mediator|sequence-specific DNA binding|regulation of osteoblast differentiation|metal ion binding|epithelium development|Notch signaling involved in heart development|negative regulation of vitamin D receptor signaling pathway|E-box binding|cellular response to epidermal growth factor stimulus|negative regulation of canonical Wnt signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|sequence-specific double-stranded DNA binding|regulation of bicellular tight junction assembly|negative regulation of anoikis|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04390,hsa04520" Hippo signaling pathway|Adherens junction zf-C2H2 SNAI3 17.00187327 17.25425146 16.74949508 0.970745971 -0.042834281 1 1 0.502222395 0.508531197 333929 snail family transcriptional repressor 3 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005507,GO:0005634,GO:0005667,GO:0006355,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|copper ion binding|nucleus|transcription regulator complex|regulation of transcription, DNA-templated|sequence-specific double-stranded DNA binding" SNAP23 955.3130747 983.4923334 927.133816 0.942695519 -0.085136224 0.812929487 1 13.18782556 12.96762869 8773 synaptosome associated protein 23 "GO:0002479,GO:0002553,GO:0005484,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005886,GO:0005912,GO:0005925,GO:0006887,GO:0006892,GO:0006903,GO:0006906,GO:0015031,GO:0016082,GO:0019905,GO:0030670,GO:0031201,GO:0031629,GO:0035579,GO:0042581,GO:0042582,GO:0043005,GO:0043312,GO:0061025,GO:0070062,GO:0070821,GO:0098793" "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|histamine secretion by mast cell|SNAP receptor activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|plasma membrane|adherens junction|focal adhesion|exocytosis|post-Golgi vesicle-mediated transport|vesicle targeting|vesicle fusion|protein transport|synaptic vesicle priming|syntaxin binding|phagocytic vesicle membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|specific granule membrane|specific granule|azurophil granule|neuron projection|neutrophil degranulation|membrane fusion|extracellular exosome|tertiary granule membrane|presynapse" "hsa04130,hsa04611" SNARE interactions in vesicular transport|Platelet activation SNAP25 23.56939551 28.41876711 18.72002391 0.65872048 -0.60226169 0.58686198 1 0.469136343 0.322341464 6616 synaptosome associated protein 25 "GO:0001504,GO:0001917,GO:0005249,GO:0005484,GO:0005515,GO:0005737,GO:0005802,GO:0005829,GO:0005856,GO:0005886,GO:0006887,GO:0006906,GO:0007268,GO:0007269,GO:0007626,GO:0008021,GO:0008076,GO:0008306,GO:0010975,GO:0014047,GO:0016020,GO:0016079,GO:0016081,GO:0016082,GO:0017075,GO:0019905,GO:0030426,GO:0031083,GO:0031201,GO:0031234,GO:0031629,GO:0031982,GO:0035579,GO:0036477,GO:0042734,GO:0043005,GO:0043312,GO:0048306,GO:0048471,GO:0050796,GO:0060291,GO:0070032,GO:0070821,GO:0071805,GO:0098794,GO:0098967,GO:0098978,GO:0099590" neurotransmitter uptake|photoreceptor inner segment|voltage-gated potassium channel activity|SNAP receptor activity|protein binding|cytoplasm|trans-Golgi network|cytosol|cytoskeleton|plasma membrane|exocytosis|vesicle fusion|chemical synaptic transmission|neurotransmitter secretion|locomotory behavior|synaptic vesicle|voltage-gated potassium channel complex|associative learning|regulation of neuron projection development|glutamate secretion|membrane|synaptic vesicle exocytosis|synaptic vesicle docking|synaptic vesicle priming|syntaxin-1 binding|syntaxin binding|growth cone|BLOC-1 complex|SNARE complex|extrinsic component of cytoplasmic side of plasma membrane|synaptic vesicle fusion to presynaptic active zone membrane|vesicle|specific granule membrane|somatodendritic compartment|presynaptic membrane|neuron projection|neutrophil degranulation|calcium-dependent protein binding|perinuclear region of cytoplasm|regulation of insulin secretion|long-term synaptic potentiation|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|tertiary granule membrane|potassium ion transmembrane transport|postsynapse|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|glutamatergic synapse|neurotransmitter receptor internalization "hsa04721,hsa04911" Synaptic vesicle cycle|Insulin secretion SNAP29 1182.64589 1100.21227 1265.079511 1.149850393 0.201446165 0.557583372 1 13.08332241 15.69189204 9342 synaptosome associated protein 29 "GO:0000139,GO:0000421,GO:0005484,GO:0005515,GO:0005654,GO:0005737,GO:0005776,GO:0005813,GO:0005829,GO:0005886,GO:0006887,GO:0006903,GO:0006906,GO:0015031,GO:0016082,GO:0016240,GO:0019905,GO:0020018,GO:0031201,GO:0031629,GO:0035577,GO:0043312,GO:0060271,GO:0061025,GO:0097352,GO:0098793" Golgi membrane|autophagosome membrane|SNAP receptor activity|protein binding|nucleoplasm|cytoplasm|autophagosome|centrosome|cytosol|plasma membrane|exocytosis|vesicle targeting|vesicle fusion|protein transport|synaptic vesicle priming|autophagosome membrane docking|syntaxin binding|ciliary pocket membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|azurophil granule membrane|neutrophil degranulation|cilium assembly|membrane fusion|autophagosome maturation|presynapse "hsa04130,hsa04140" SNARE interactions in vesicular transport|Autophagy - animal SNAP47 926.0723467 937.8193148 914.3253786 0.974948334 -0.036602328 0.921429506 1 6.678464548 6.79163216 116841 synaptosome associated protein 47 "GO:0005484,GO:0005515,GO:0005886,GO:0006887,GO:0006906,GO:0012505,GO:0016082,GO:0019905,GO:0031083,GO:0031201,GO:0031629,GO:0048471,GO:0098793" SNAP receptor activity|protein binding|plasma membrane|exocytosis|vesicle fusion|endomembrane system|synaptic vesicle priming|syntaxin binding|BLOC-1 complex|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|perinuclear region of cytoplasm|presynapse SNAPC1 918.6477288 1002.776497 834.5189608 0.832208337 -0.264983354 0.459458019 1 19.58622907 17.0019534 6617 small nuclear RNA activating complex polypeptide 1 "GO:0000995,GO:0005515,GO:0005654,GO:0005730,GO:0016251,GO:0019185,GO:0042795,GO:0042796,GO:0043565" RNA polymerase III general transcription initiation factor activity|protein binding|nucleoplasm|nucleolus|RNA polymerase II general transcription initiation factor activity|snRNA-activating protein complex|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III|sequence-specific DNA binding other SNAPC2 583.0251481 521.6873677 644.3629284 1.235151488 0.304687995 0.439704242 1 17.38264788 22.39505267 6618 small nuclear RNA activating complex polypeptide 2 "GO:0005634,GO:0005654,GO:0005829,GO:0006366,GO:0006383,GO:0009301,GO:0016251,GO:0016604,GO:0042795" nucleus|nucleoplasm|cytosol|transcription by RNA polymerase II|transcription by RNA polymerase III|snRNA transcription|RNA polymerase II general transcription initiation factor activity|nuclear body|snRNA transcription by RNA polymerase II other SNAPC3 743.6338883 758.1721084 729.0956682 0.961649288 -0.056417254 0.883118777 1 4.674223082 4.688588088 6619 small nuclear RNA activating complex polypeptide 3 "GO:0000978,GO:0000995,GO:0001006,GO:0001046,GO:0003677,GO:0003681,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006366,GO:0006383,GO:0009301,GO:0016604,GO:0019185,GO:0042795,GO:0042796" RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase III general transcription initiation factor activity|RNA polymerase III type 3 promoter sequence-specific DNA binding|core promoter sequence-specific DNA binding|DNA binding|bent DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|transcription by RNA polymerase II|transcription by RNA polymerase III|snRNA transcription|nuclear body|snRNA-activating protein complex|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III SNAPC4 575.4345051 608.973581 541.8954291 0.889850473 -0.168365163 0.67219371 1 5.421403331 5.03204694 6621 small nuclear RNA activating complex polypeptide 4 "GO:0000995,GO:0003677,GO:0005634,GO:0005654,GO:0016251,GO:0019185,GO:0042795,GO:0042796" RNA polymerase III general transcription initiation factor activity|DNA binding|nucleus|nucleoplasm|RNA polymerase II general transcription initiation factor activity|snRNA-activating protein complex|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III MYB SNAPC5 224.205554 206.0360616 242.3750465 1.176371964 0.234344307 0.656463642 1 4.315549904 5.295375216 10302 small nuclear RNA activating complex polypeptide 5 "GO:0000995,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006384,GO:0016251,GO:0016604,GO:0042795,GO:0042796" RNA polymerase III general transcription initiation factor activity|protein binding|nucleus|nucleoplasm|nucleolus|transcription initiation from RNA polymerase III promoter|RNA polymerase II general transcription initiation factor activity|nuclear body|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III other SNAPIN 729.8253407 757.1571524 702.493529 0.927804125 -0.108107835 0.775423908 1 38.23264076 37.000409 23557 SNAP associated protein "GO:0000139,GO:0000149,GO:0001669,GO:0002177,GO:0005515,GO:0005765,GO:0006886,GO:0007040,GO:0007042,GO:0007269,GO:0008021,GO:0008089,GO:0008090,GO:0008333,GO:0010977,GO:0016032,GO:0016079,GO:0016188,GO:0030141,GO:0030672,GO:0031083,GO:0031175,GO:0031629,GO:0032418,GO:0032438,GO:0034629,GO:0043393,GO:0045202,GO:0048471,GO:0048489,GO:0048490,GO:0051604,GO:0072553,GO:0097352,GO:0099078,GO:1902774,GO:1902824,GO:1904115,GO:2000300" Golgi membrane|SNARE binding|acrosomal vesicle|manchette|protein binding|lysosomal membrane|intracellular protein transport|lysosome organization|lysosomal lumen acidification|neurotransmitter secretion|synaptic vesicle|anterograde axonal transport|retrograde axonal transport|endosome to lysosome transport|negative regulation of neuron projection development|viral process|synaptic vesicle exocytosis|synaptic vesicle maturation|secretory granule|synaptic vesicle membrane|BLOC-1 complex|neuron projection development|synaptic vesicle fusion to presynaptic active zone membrane|lysosome localization|melanosome organization|cellular protein-containing complex localization|regulation of protein binding|synapse|perinuclear region of cytoplasm|synaptic vesicle transport|anterograde synaptic vesicle transport|protein maturation|terminal button organization|autophagosome maturation|BORC complex|late endosome to lysosome transport|positive regulation of late endosome to lysosome transport|axon cytoplasm|regulation of synaptic vesicle exocytosis SNCA 87.0419999 56.83753423 117.2464656 2.062835187 1.04462856 0.142701686 1 0.651271628 1.4013371 6622 synuclein alpha "GO:0000122,GO:0000149,GO:0000287,GO:0000976,GO:0001774,GO:0001921,GO:0003779,GO:0004860,GO:0005504,GO:0005507,GO:0005509,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005764,GO:0005829,GO:0005886,GO:0005938,GO:0006469,GO:0006915,GO:0006919,GO:0007268,GO:0008198,GO:0008270,GO:0010040,GO:0010517,GO:0010642,GO:0014059,GO:0015629,GO:0016020,GO:0016079,GO:0016082,GO:0016234,GO:0016491,GO:0019894,GO:0022898,GO:0030424,GO:0030426,GO:0030544,GO:0031092,GO:0031115,GO:0031623,GO:0031648,GO:0032026,GO:0032410,GO:0032496,GO:0032769,GO:0032991,GO:0033138,GO:0034341,GO:0034599,GO:0035067,GO:0035493,GO:0035543,GO:0042393,GO:0042416,GO:0042802,GO:0043014,GO:0043025,GO:0043027,GO:0043065,GO:0043066,GO:0043154,GO:0043679,GO:0044267,GO:0045807,GO:0045920,GO:0045921,GO:0048156,GO:0048471,GO:0048488,GO:0050729,GO:0050808,GO:0051219,GO:0051262,GO:0051281,GO:0051583,GO:0051585,GO:0051612,GO:0051621,GO:0051622,GO:0055074,GO:0055114,GO:0060732,GO:0060961,GO:0070495,GO:0070555,GO:0070840,GO:0071280,GO:0071872,GO:0071902,GO:0097435,GO:0099512,GO:1901214,GO:1901215,GO:1901216,GO:1902957,GO:1903136,GO:1903284,GO:1903285,GO:1903421,GO:1903426,GO:1904715,GO:1905606" "negative regulation of transcription by RNA polymerase II|SNARE binding|magnesium ion binding|transcription regulatory region sequence-specific DNA binding|microglial cell activation|positive regulation of receptor recycling|actin binding|protein kinase inhibitor activity|fatty acid binding|copper ion binding|calcium ion binding|protein binding|phospholipid binding|extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|lysosome|cytosol|plasma membrane|cell cortex|negative regulation of protein kinase activity|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|chemical synaptic transmission|ferrous iron binding|zinc ion binding|response to iron(II) ion|regulation of phospholipase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|regulation of dopamine secretion|actin cytoskeleton|membrane|synaptic vesicle exocytosis|synaptic vesicle priming|inclusion body|oxidoreductase activity|kinesin binding|regulation of transmembrane transporter activity|axon|growth cone|Hsp70 protein binding|platelet alpha granule membrane|negative regulation of microtubule polymerization|receptor internalization|protein destabilization|response to magnesium ion|negative regulation of transporter activity|response to lipopolysaccharide|negative regulation of monooxygenase activity|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|response to interferon-gamma|cellular response to oxidative stress|negative regulation of histone acetylation|SNARE complex assembly|positive regulation of SNARE complex assembly|histone binding|dopamine biosynthetic process|identical protein binding|alpha-tubulin binding|neuronal cell body|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|axon terminus|cellular protein metabolic process|positive regulation of endocytosis|negative regulation of exocytosis|positive regulation of exocytosis|tau protein binding|perinuclear region of cytoplasm|synaptic vesicle endocytosis|positive regulation of inflammatory response|synapse organization|phosphoprotein binding|protein tetramerization|positive regulation of release of sequestered calcium ion into cytosol|dopamine uptake involved in synaptic transmission|negative regulation of dopamine uptake involved in synaptic transmission|negative regulation of serotonin uptake|regulation of norepinephrine uptake|negative regulation of norepinephrine uptake|calcium ion homeostasis|oxidation-reduction process|positive regulation of inositol phosphate biosynthetic process|phospholipase D inhibitor activity|negative regulation of thrombin-activated receptor signaling pathway|response to interleukin-1|dynein complex binding|cellular response to copper ion|cellular response to epinephrine stimulus|positive regulation of protein serine/threonine kinase activity|supramolecular fiber organization|supramolecular fiber|regulation of neuron death|negative regulation of neuron death|positive regulation of neuron death|negative regulation of mitochondrial electron transport, NADH to ubiquinone|cuprous ion binding|positive regulation of glutathione peroxidase activity|positive regulation of hydrogen peroxide catabolic process|regulation of synaptic vesicle recycling|regulation of reactive oxygen species biosynthetic process|negative regulation of chaperone-mediated autophagy|regulation of presynapse assembly" "hsa05010,hsa05012,hsa05022" Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases SNCAIP 3.463271234 1.014955968 5.911586499 5.824475823 2.542128219 0.321345721 1 0.00621872 0.037781029 9627 synuclein alpha interacting protein "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008021,GO:0008219,GO:0031625,GO:0036464,GO:0042417,GO:0042734,GO:0042802,GO:0043025,GO:0044267,GO:0046928,GO:0090083" protein binding|nucleoplasm|cytoplasm|cytosol|synaptic vesicle|cell death|ubiquitin protein ligase binding|cytoplasmic ribonucleoprotein granule|dopamine metabolic process|presynaptic membrane|identical protein binding|neuronal cell body|cellular protein metabolic process|regulation of neurotransmitter secretion|regulation of inclusion body assembly "hsa05012,hsa05022" Parkinson disease|Pathways of neurodegeneration - multiple diseases SNCG 46.6610046 57.8524902 35.469519 0.613102718 -0.705799294 0.41998343 1 2.892423038 1.849741257 6623 synuclein gamma "GO:0005515,GO:0005737,GO:0005813,GO:0005819,GO:0007268,GO:0008344,GO:0009306,GO:0014059,GO:0043025,GO:0043679,GO:0046928,GO:0048471,GO:0048488,GO:0050808,GO:0070062,GO:1901214,GO:1903136" protein binding|cytoplasm|centrosome|spindle|chemical synaptic transmission|adult locomotory behavior|protein secretion|regulation of dopamine secretion|neuronal cell body|axon terminus|regulation of neurotransmitter secretion|perinuclear region of cytoplasm|synaptic vesicle endocytosis|synapse organization|extracellular exosome|regulation of neuron death|cuprous ion binding SND1 8418.896671 8373.386739 8464.406603 1.010870137 0.015597672 0.96288139 1 52.47246954 55.32772345 27044 staphylococcal nuclease and tudor domain containing 1 "GO:0001649,GO:0003712,GO:0003723,GO:0004518,GO:0004519,GO:0004521,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006401,GO:0010564,GO:0010587,GO:0016020,GO:0016032,GO:0016442,GO:0031047,GO:0042470,GO:0045296,GO:0070062,GO:0090502,GO:0097433,GO:1905172" "osteoblast differentiation|transcription coregulator activity|RNA binding|nuclease activity|endonuclease activity|endoribonuclease activity|protein binding|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|RNA catabolic process|regulation of cell cycle process|miRNA catabolic process|membrane|viral process|RISC complex|gene silencing by RNA|melanosome|cadherin binding|extracellular exosome|RNA phosphodiester bond hydrolysis, endonucleolytic|dense body|RISC complex binding" hsa05203 Viral carcinogenesis SNED1 44.67562999 56.83753423 32.51372575 0.572046733 -0.805795084 0.362210324 1 0.269432853 0.1607674 25992 "sushi, nidogen and EGF like domains 1" "GO:0005112,GO:0005509,GO:0005576,GO:0007160" Notch binding|calcium ion binding|extracellular region|cell-matrix adhesion SNF8 1671.95339 1782.26268 1561.6441 0.87621433 -0.190644286 0.560919768 1 43.48040333 39.73926637 11267 SNF8 subunit of ESCRT-II "GO:0000814,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0008022,GO:0008134,GO:0010008,GO:0010628,GO:0010797,GO:0016020,GO:0016197,GO:0016236,GO:0016247,GO:0031902,GO:0032456,GO:0036258,GO:0042176,GO:0042803,GO:0043328,GO:0043405,GO:0045022,GO:0045732,GO:0047485,GO:0048471,GO:0055037,GO:0061635,GO:0070062,GO:0071985,GO:1903543,GO:1903772" ESCRT II complex|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|protein C-terminus binding|transcription factor binding|endosome membrane|positive regulation of gene expression|regulation of multivesicular body size involved in endosome transport|membrane|endosomal transport|macroautophagy|channel regulator activity|late endosome membrane|endocytic recycling|multivesicular body assembly|regulation of protein catabolic process|protein homodimerization activity|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|regulation of MAP kinase activity|early endosome to late endosome transport|positive regulation of protein catabolic process|protein N-terminus binding|perinuclear region of cytoplasm|recycling endosome|regulation of protein complex stability|extracellular exosome|multivesicular body sorting pathway|positive regulation of exosomal secretion|regulation of viral budding via host ESCRT complex hsa04144 Endocytosis SNIP1 344.7086877 361.3243247 328.0930507 0.908029236 -0.139189345 0.763288495 1 4.018401926 3.806003077 79753 Smad nuclear interacting protein 1 "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007249,GO:0035196,GO:0071005" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|I-kappaB kinase/NF-kappaB signaling|production of miRNAs involved in gene silencing by miRNA|U2-type precatalytic spliceosome" SNN 543.6415414 557.2108266 530.0722561 0.951295687 -0.072034258 0.861309299 1 8.213260375 8.149801826 8303 stannin "GO:0005737,GO:0005741,GO:0009636,GO:0016021,GO:0046872" cytoplasm|mitochondrial outer membrane|response to toxic substance|integral component of membrane|metal ion binding SNORC 43.13835026 52.77771036 33.49899016 0.634718519 -0.655811158 0.46621407 1 0.537071497 0.355573351 389084 secondary ossification center associated regulator of chondrocyte maturation "GO:0005515,GO:0005737,GO:0016021,GO:0051216,GO:0062023,GO:0071944" protein binding|cytoplasm|integral component of membrane|cartilage development|collagen-containing extracellular matrix|cell periphery SNPH 947.2515723 802.830171 1091.672974 1.359780702 0.443374 0.212848207 1 7.14094063 10.12838556 9751 syntaphilin "GO:0005515,GO:0005737,GO:0005739,GO:0005881,GO:0007269,GO:0007420,GO:0008017,GO:0016021,GO:0016081,GO:0017075,GO:0030182,GO:0031966,GO:0042734,GO:0043005,GO:0043025" protein binding|cytoplasm|mitochondrion|cytoplasmic microtubule|neurotransmitter secretion|brain development|microtubule binding|integral component of membrane|synaptic vesicle docking|syntaxin-1 binding|neuron differentiation|mitochondrial membrane|presynaptic membrane|neuron projection|neuronal cell body SNRK 814.0087868 719.6037816 908.4137921 1.262380515 0.336146842 0.358866411 1 6.920887377 9.113138993 54861 SNF related kinase "GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0030099,GO:0035556,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|myeloid cell differentiation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity SNRNP200 7453.709425 7287.383853 7620.034998 1.04564754 0.064396639 0.845070032 1 51.30390378 55.9566443 23020 small nuclear ribonucleoprotein U5 subunit 200 "GO:0000354,GO:0000388,GO:0000398,GO:0001649,GO:0003723,GO:0003724,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0016020,GO:0042802,GO:0046540,GO:0071005,GO:0071006,GO:0071013" "cis assembly of pre-catalytic spliceosome|spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)|mRNA splicing, via spliceosome|osteoblast differentiation|RNA binding|RNA helicase activity|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|membrane|identical protein binding|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRNP25 691.4824221 661.7512914 721.2135529 1.089855906 0.124137403 0.745659461 1 30.8329056 35.05092349 79622 small nuclear ribonucleoprotein U11/U12 subunit 25 "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005689,GO:0005829,GO:0008380,GO:0045171" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|U12-type spliceosomal complex|cytosol|RNA splicing|intercellular bridge" SNRNP27 361.4163671 324.7859099 398.0468243 1.225566788 0.293449107 0.513049937 1 11.54334074 14.75653624 11017 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 "GO:0000398,GO:0003676,GO:0005515,GO:0005575,GO:0005654,GO:0008150" "mRNA splicing, via spliceosome|nucleic acid binding|protein binding|cellular_component|nucleoplasm|biological_process" hsa03040 Spliceosome SNRNP35 325.3151607 382.6384001 267.9919213 0.700379056 -0.513792153 0.265484619 1 7.260878642 5.304424327 11066 small nuclear ribonucleoprotein U11/U12 subunit 35 "GO:0000398,GO:0003729,GO:0005634,GO:0005654,GO:0005689,GO:0005730,GO:0008380,GO:0017069" "mRNA splicing, via spliceosome|mRNA binding|nucleus|nucleoplasm|U12-type spliceosomal complex|nucleolus|RNA splicing|snRNA binding" SNRNP40 995.032691 1038.299956 951.7654264 0.916657485 -0.125545332 0.723628105 1 32.56113303 31.13311154 9410 small nuclear ribonucleoprotein U5 subunit 40 "GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005682,GO:0005732,GO:0005829,GO:0006396,GO:0008380,GO:0016607,GO:0071007,GO:0071013" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|U5 snRNP|sno(s)RNA-containing ribonucleoprotein complex|cytosol|RNA processing|RNA splicing|nuclear speck|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRNP48 345.4091608 375.5337083 315.2846133 0.839564083 -0.252287647 0.579914186 1 4.673085386 4.092356852 154007 small nuclear ribonucleoprotein U11/U12 subunit 48 "GO:0000398,GO:0005515,GO:0005654,GO:0005689,GO:0005829,GO:0008380,GO:0046872" "mRNA splicing, via spliceosome|protein binding|nucleoplasm|U12-type spliceosomal complex|cytosol|RNA splicing|metal ion binding" SNRNP70 3041.447181 2993.105151 3089.78921 1.03230226 0.045865456 0.886286606 1 77.34194737 83.27946193 6625 small nuclear ribonucleoprotein U1 subunit 70 "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005685,GO:0016607,GO:0017069,GO:0030619,GO:0043462,GO:0043484,GO:0048026,GO:0061084,GO:0071004,GO:1904715" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U1 snRNP|nuclear speck|snRNA binding|U1 snRNA binding|regulation of ATPase activity|regulation of RNA splicing|positive regulation of mRNA splicing, via spliceosome|negative regulation of protein refolding|U2-type prespliceosome|negative regulation of chaperone-mediated autophagy" hsa03040 Spliceosome SNRPA 1640.742134 1736.589662 1544.894605 0.889614075 -0.168748482 0.607695604 1 68.87403293 63.91062858 6626 small nuclear ribonucleoprotein polypeptide A "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005681,GO:0005685,GO:0030619,GO:0042802,GO:1900363,GO:1990446" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|spliceosomal complex|U1 snRNP|U1 snRNA binding|identical protein binding|regulation of mRNA polyadenylation|U1 snRNP binding" hsa03040 Spliceosome SNRPA1 766.1546769 647.5419078 884.7674461 1.366347777 0.45032474 0.224498376 1 31.17463236 44.43022624 6627 small nuclear ribonucleoprotein polypeptide A' "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005686,GO:0007283,GO:0008380,GO:0016604,GO:0016607,GO:0030532,GO:0030620,GO:0035722,GO:0071005,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2 snRNP|spermatogenesis|RNA splicing|nuclear body|nuclear speck|small nuclear ribonucleoprotein complex|U2 snRNA binding|interleukin-12-mediated signaling pathway|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRPB 8834.789102 8111.528099 9558.050105 1.178329162 0.236742607 0.477297757 1 379.6860282 466.6670865 6628 small nuclear ribonucleoprotein polypeptides B and B1 "GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005697,GO:0005737,GO:0005829,GO:0006369,GO:0006479,GO:0007420,GO:0008334,GO:0008380,GO:0030532,GO:0034709,GO:0034719,GO:0046540,GO:0051170,GO:0070034,GO:0071004,GO:0071005,GO:0071007,GO:0071013,GO:0071204,GO:0071208,GO:1990446,GO:1990447" "spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|telomerase holoenzyme complex|cytoplasm|cytosol|termination of RNA polymerase II transcription|protein methylation|brain development|histone mRNA metabolic process|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|import into nucleus|telomerase RNA binding|U2-type prespliceosome|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|histone pre-mRNA 3'end processing complex|histone pre-mRNA DCP binding|U1 snRNP binding|U2 snRNP binding" "hsa03040,hsa05322" Spliceosome|Systemic lupus erythematosus SNRPB2 1770.595877 1823.875875 1717.315878 0.941574973 -0.086852121 0.79087106 1 39.97095579 39.25684286 6629 small nuclear ribonucleoprotein polypeptide B2 "GO:0000398,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005685,GO:0005686,GO:0016607,GO:0030619,GO:0036464,GO:0070990,GO:0071005,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|fibrillar center|protein binding|nucleus|nucleoplasm|spliceosomal complex|U1 snRNP|U2 snRNP|nuclear speck|U1 snRNA binding|cytoplasmic ribonucleoprotein granule|snRNP binding|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRPC 1410.452287 1451.387035 1369.517539 0.943592237 -0.083764545 0.803685796 1 91.20053738 89.76306768 6631 small nuclear ribonucleoprotein polypeptide C "GO:0000243,GO:0000387,GO:0000395,GO:0000398,GO:0003723,GO:0003727,GO:0003729,GO:0005515,GO:0005654,GO:0005685,GO:0008270,GO:0015030,GO:0030619,GO:0030627,GO:0042803,GO:0071004" "commitment complex|spliceosomal snRNP assembly|mRNA 5'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|mRNA binding|protein binding|nucleoplasm|U1 snRNP|zinc ion binding|Cajal body|U1 snRNA binding|pre-mRNA 5'-splice site binding|protein homodimerization activity|U2-type prespliceosome" hsa03040 Spliceosome SNRPD1 1356.953814 1397.594368 1316.313261 0.941842133 -0.086442833 0.798579787 1 14.57044552 14.31419323 6632 small nuclear ribonucleoprotein D1 polypeptide "GO:0000243,GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005682,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005829,GO:0008380,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0046540,GO:0051170,GO:0071005,GO:0071007,GO:0071011,GO:0071013,GO:0097526,GO:1990446" "commitment complex|spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U5 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|cytosol|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|import into nucleus|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|spliceosomal tri-snRNP complex|U1 snRNP binding" "hsa03040,hsa05322" Spliceosome|Systemic lupus erythematosus SNRPD2 3664.245639 4011.105987 3317.385291 0.827050021 -0.273953507 0.389482587 1 230.0661018 198.4725002 6633 small nuclear ribonucleoprotein D2 polypeptide "GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005829,GO:0008380,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0046540,GO:0051170,GO:0070062,GO:0071005,GO:0071007,GO:0071011,GO:0071013,GO:1990446" "spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|cytosol|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|import into nucleus|extracellular exosome|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|U1 snRNP binding" hsa03040 Spliceosome SNRPD3 2377.820624 2518.105758 2237.53549 0.888578839 -0.17042831 0.594118722 1 36.94471995 34.24240622 6634 small nuclear ribonucleoprotein D3 polypeptide "GO:0000243,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005697,GO:0005829,GO:0006369,GO:0006479,GO:0008334,GO:0008380,GO:0016604,GO:0019899,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0046540,GO:0051170,GO:0070034,GO:0071005,GO:0071007,GO:0071011,GO:0071013,GO:0071208,GO:0071209,GO:0097526" "commitment complex|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|telomerase holoenzyme complex|cytosol|termination of RNA polymerase II transcription|protein methylation|histone mRNA metabolic process|RNA splicing|nuclear body|enzyme binding|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|import into nucleus|telomerase RNA binding|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|histone pre-mRNA DCP binding|U7 snRNA binding|spliceosomal tri-snRNP complex" "hsa03040,hsa05322" Spliceosome|Systemic lupus erythematosus SNRPE 1035.490637 1008.866233 1062.115041 1.052780841 0.07420514 0.834535917 1 30.35978349 33.33900028 6635 small nuclear ribonucleoprotein polypeptide E "GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005697,GO:0005829,GO:0006369,GO:0008334,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0042633,GO:0046540,GO:0051170,GO:0071005,GO:0071007,GO:0071011,GO:0071013" "spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|telomerase holoenzyme complex|cytosol|termination of RNA polymerase II transcription|histone mRNA metabolic process|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|hair cycle|U4/U6 x U5 tri-snRNP complex|import into nucleus|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRPF 1292.404149 1396.579412 1188.228886 0.850813692 -0.233084844 0.491276797 1 49.91659873 44.29914921 6636 small nuclear ribonucleoprotein polypeptide F "GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005683,GO:0005685,GO:0005687,GO:0005689,GO:0005732,GO:0005829,GO:0006369,GO:0008334,GO:0008380,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0046540,GO:0051170,GO:0071005,GO:0071007,GO:0071013" "spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U7 snRNP|U1 snRNP|U4 snRNP|U12-type spliceosomal complex|sno(s)RNA-containing ribonucleoprotein complex|cytosol|termination of RNA polymerase II transcription|histone mRNA metabolic process|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|import into nucleus|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRPG 1455.199424 1546.792896 1363.605953 0.881569831 -0.181853241 0.585486474 1 49.92963889 45.91251407 6637 small nuclear ribonucleoprotein polypeptide G "GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005829,GO:0006369,GO:0008334,GO:0008380,GO:0030532,GO:0034709,GO:0034719,GO:0043186,GO:0046540,GO:0051170,GO:0071004,GO:0071005,GO:0071007,GO:0071011,GO:0071013,GO:0097526,GO:1990904" "spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|cytosol|termination of RNA polymerase II transcription|histone mRNA metabolic process|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|SMN-Sm protein complex|P granule|U4/U6 x U5 tri-snRNP complex|import into nucleus|U2-type prespliceosome|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|spliceosomal tri-snRNP complex|ribonucleoprotein complex" hsa03040 Spliceosome SNRPN 14.52386645 16.23929549 12.80843742 0.788731101 -0.342394563 0.827932218 1 0.242686051 0.199659377 6638 small nuclear ribonucleoprotein polypeptide N "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005681,GO:0005682,GO:0005685,GO:0005686,GO:0005687,GO:0005737,GO:0008380,GO:0009725,GO:0030532,GO:0046540,GO:0071004,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|spliceosomal complex|U5 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|cytoplasm|RNA splicing|response to hormone|small nuclear ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|catalytic step 2 spliceosome" SNTA1 779.1100883 859.6677052 698.5524713 0.812584289 -0.299410623 0.41805928 1 17.4295983 14.77310311 6640 syntrophin alpha 1 "GO:0002027,GO:0003117,GO:0003779,GO:0005198,GO:0005515,GO:0005516,GO:0005622,GO:0005737,GO:0005856,GO:0006936,GO:0007528,GO:0016010,GO:0016013,GO:0016328,GO:0017080,GO:0030165,GO:0031594,GO:0032991,GO:0042383,GO:0044325,GO:0045202,GO:0045211,GO:0050998,GO:0051117,GO:0060307,GO:0086005,GO:1902083,GO:1902305" regulation of heart rate|regulation of vasoconstriction by circulating norepinephrine|actin binding|structural molecule activity|protein binding|calmodulin binding|intracellular anatomical structure|cytoplasm|cytoskeleton|muscle contraction|neuromuscular junction development|dystrophin-associated glycoprotein complex|syntrophin complex|lateral plasma membrane|sodium channel regulator activity|PDZ domain binding|neuromuscular junction|protein-containing complex|sarcolemma|ion channel binding|synapse|postsynaptic membrane|nitric-oxide synthase binding|ATPase binding|regulation of ventricular cardiac muscle cell membrane repolarization|ventricular cardiac muscle cell action potential|negative regulation of peptidyl-cysteine S-nitrosylation|regulation of sodium ion transmembrane transport SNTB1 331.0377115 504.4331163 157.6423066 0.312513793 -1.678008228 0.000353168 0.04318862 4.971348085 1.620538275 6641 syntrophin beta 1 "GO:0003779,GO:0005198,GO:0005515,GO:0005516,GO:0005622,GO:0005737,GO:0005856,GO:0005925,GO:0006936,GO:0016010,GO:0030165,GO:0032991,GO:0042383,GO:0045202" actin binding|structural molecule activity|protein binding|calmodulin binding|intracellular anatomical structure|cytoplasm|cytoskeleton|focal adhesion|muscle contraction|dystrophin-associated glycoprotein complex|PDZ domain binding|protein-containing complex|sarcolemma|synapse SNTB2 649.0296992 622.1680086 675.8913898 1.086348672 0.119487221 0.758520734 1 3.22491196 3.654290175 6645 syntrophin beta 2 "GO:0003723,GO:0003779,GO:0005198,GO:0005515,GO:0005516,GO:0005622,GO:0005654,GO:0005737,GO:0005794,GO:0005874,GO:0005886,GO:0005925,GO:0016010,GO:0016020,GO:0030658,GO:0032991,GO:0045202" RNA binding|actin binding|structural molecule activity|protein binding|calmodulin binding|intracellular anatomical structure|nucleoplasm|cytoplasm|Golgi apparatus|microtubule|plasma membrane|focal adhesion|dystrophin-associated glycoprotein complex|membrane|transport vesicle membrane|protein-containing complex|synapse SNU13 1967.193738 2095.884075 1838.503401 0.877197085 -0.189027077 0.558398067 1 40.01098174 36.60937523 4809 small nuclear ribonucleoprotein 13 "GO:0000398,GO:0000470,GO:0001651,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005690,GO:0005730,GO:0006364,GO:0030490,GO:0030515,GO:0030621,GO:0030622,GO:0031428,GO:0032040,GO:0032991,GO:0034511,GO:0034512,GO:0046540,GO:0051117,GO:0071005,GO:0071011" "mRNA splicing, via spliceosome|maturation of LSU-rRNA|dense fibrillar component|RNA binding|protein binding|nucleus|nucleoplasm|U4atac snRNP|nucleolus|rRNA processing|maturation of SSU-rRNA|snoRNA binding|U4 snRNA binding|U4atac snRNA binding|box C/D RNP complex|small-subunit processome|protein-containing complex|U3 snoRNA binding|box C/D RNA binding|U4/U6 x U5 tri-snRNP complex|ATPase binding|U2-type precatalytic spliceosome|precatalytic spliceosome" "hsa03008,hsa03040" Ribosome biogenesis in eukaryotes|Spliceosome SNUPN 691.957487 694.2298824 689.6850916 0.993453479 -0.009475684 0.98432302 1 16.65575294 17.2594811 10073 snurportin 1 "GO:0000339,GO:0000387,GO:0005515,GO:0005643,GO:0005829,GO:0006606,GO:0051170,GO:0061015,GO:0061608" RNA cap binding|spliceosomal snRNP assembly|protein binding|nuclear pore|cytosol|protein import into nucleus|import into nucleus|snRNA import into nucleus|nuclear import signal receptor activity hsa03013 RNA transport SNW1 1673.612158 1760.948605 1586.275711 0.9008075 -0.150709256 0.646065583 1 40.37384998 37.93569876 22938 SNW domain containing 1 "GO:0000122,GO:0000398,GO:0003713,GO:0003714,GO:0003723,GO:0005112,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006357,GO:0006367,GO:0007219,GO:0007221,GO:0008024,GO:0016032,GO:0016363,GO:0016604,GO:0016607,GO:0019899,GO:0030511,GO:0035257,GO:0042771,GO:0042809,GO:0042974,GO:0043923,GO:0045747,GO:0045892,GO:0045944,GO:0046332,GO:0048026,GO:0048384,GO:0048385,GO:0050681,GO:0050769,GO:0051571,GO:0070562,GO:0070564,GO:0071007,GO:0071013,GO:0071300" "negative regulation of transcription by RNA polymerase II|mRNA splicing, via spliceosome|transcription coactivator activity|transcription corepressor activity|RNA binding|Notch binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|positive regulation of transcription of Notch receptor target|cyclin/CDK positive transcription elongation factor complex|viral process|nuclear matrix|nuclear body|nuclear speck|enzyme binding|positive regulation of transforming growth factor beta receptor signaling pathway|nuclear hormone receptor binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|vitamin D receptor binding|retinoic acid receptor binding|positive regulation by host of viral transcription|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|positive regulation of mRNA splicing, via spliceosome|retinoic acid receptor signaling pathway|regulation of retinoic acid receptor signaling pathway|androgen receptor binding|positive regulation of neurogenesis|positive regulation of histone H3-K4 methylation|regulation of vitamin D receptor signaling pathway|positive regulation of vitamin D receptor signaling pathway|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|cellular response to retinoic acid" "hsa03040,hsa04330,hsa05169,hsa05203" Spliceosome|Notch signaling pathway|Epstein-Barr virus infection|Viral carcinogenesis SNX1 1999.784414 2067.465308 1932.103521 0.934527662 -0.097690726 0.762794573 1 12.34203492 12.03080982 6642 sorting nexin 1 "GO:0005154,GO:0005158,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005794,GO:0005829,GO:0006886,GO:0010008,GO:0016020,GO:0030027,GO:0030904,GO:0030905,GO:0031623,GO:0031901,GO:0031982,GO:0032991,GO:0034498,GO:0035091,GO:0042147,GO:0042802,GO:0042803,GO:0043231,GO:0045296,GO:0045732,GO:0046982,GO:0072673,GO:1990459,GO:1990460" "epidermal growth factor receptor binding|insulin receptor binding|protein binding|cytoplasm|lysosome|endosome|Golgi apparatus|cytosol|intracellular protein transport|endosome membrane|membrane|lamellipodium|retromer complex|retromer, tubulation complex|receptor internalization|early endosome membrane|vesicle|protein-containing complex|early endosome to Golgi transport|phosphatidylinositol binding|retrograde transport, endosome to Golgi|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|cadherin binding|positive regulation of protein catabolic process|protein heterodimerization activity|lamellipodium morphogenesis|transferrin receptor binding|leptin receptor binding" hsa04144 Endocytosis SNX10 190.9198479 153.2583512 228.5813446 1.491477253 0.576741975 0.292731484 1 1.860497322 2.894420417 29887 sorting nexin 10 "GO:0001696,GO:0005515,GO:0005545,GO:0005634,GO:0005783,GO:0005813,GO:0006886,GO:0006897,GO:0007032,GO:0030141,GO:0030316,GO:0031313,GO:0035630,GO:0044691,GO:0045453,GO:0051117,GO:0055074,GO:0060271,GO:0061512,GO:0071539,GO:0090651,GO:0097178,GO:1990830" gastric acid secretion|protein binding|1-phosphatidylinositol binding|nucleus|endoplasmic reticulum|centrosome|intracellular protein transport|endocytosis|endosome organization|secretory granule|osteoclast differentiation|extrinsic component of endosome membrane|bone mineralization involved in bone maturation|tooth eruption|bone resorption|ATPase binding|calcium ion homeostasis|cilium assembly|protein localization to cilium|protein localization to centrosome|apical cytoplasm|ruffle assembly|cellular response to leukemia inhibitory factor SNX11 439.0929118 448.610538 429.5752856 0.957568423 -0.062552516 0.887461819 1 7.415320218 7.406544836 29916 sorting nexin 11 "GO:0005515,GO:0005768,GO:0006886,GO:0016020,GO:0016050,GO:1901981" protein binding|endosome|intracellular protein transport|membrane|vesicle organization|phosphatidylinositol phosphate binding SNX12 2802.631407 2731.246511 2874.016303 1.05227276 0.073508714 0.818244324 1 56.78489348 62.32712194 29934 sorting nexin 12 "GO:0005515,GO:0005769,GO:0010629,GO:0010955,GO:0015031,GO:0019899,GO:0030100,GO:0030904,GO:0031901,GO:0032266,GO:0032456,GO:0033157,GO:0034499,GO:0035091,GO:0042177,GO:0051224,GO:2000642" protein binding|early endosome|negative regulation of gene expression|negative regulation of protein processing|protein transport|enzyme binding|regulation of endocytosis|retromer complex|early endosome membrane|phosphatidylinositol-3-phosphate binding|endocytic recycling|regulation of intracellular protein transport|late endosome to Golgi transport|phosphatidylinositol binding|negative regulation of protein catabolic process|negative regulation of protein transport|negative regulation of early endosome to late endosome transport hsa04144 Endocytosis SNX13 922.0219254 997.7017169 846.3421338 0.848291748 -0.237367566 0.507496494 1 4.063536171 3.595549749 23161 sorting nexin 13 "GO:0005769,GO:0006886,GO:0009968,GO:0031901,GO:0032266,GO:0035091,GO:0043547" early endosome|intracellular protein transport|negative regulation of signal transduction|early endosome membrane|phosphatidylinositol-3-phosphate binding|phosphatidylinositol binding|positive regulation of GTPase activity SNX14 1404.934855 1377.295249 1432.574462 1.040136066 0.056772267 0.867061981 1 17.39096125 18.8681653 57231 sorting nexin 14 "GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0015031,GO:0016021,GO:0030425,GO:0031902,GO:0043231,GO:0080025,GO:0097352" "lysosome|lysosomal membrane|late endosome|cytosol|protein transport|integral component of membrane|dendrite|late endosome membrane|intracellular membrane-bounded organelle|phosphatidylinositol-3,5-bisphosphate binding|autophagosome maturation" SNX15 955.2969911 813.9946866 1096.599296 1.347182376 0.42994517 0.226316544 1 21.6068969 30.36230383 29907 sorting nexin 15 "GO:0005515,GO:0005730,GO:0005769,GO:0005829,GO:0005886,GO:0006886,GO:0016020,GO:0030659,GO:0035091,GO:0043231" protein binding|nucleolus|early endosome|cytosol|plasma membrane|intracellular protein transport|membrane|cytoplasmic vesicle membrane|phosphatidylinositol binding|intracellular membrane-bounded organelle SNX16 346.3728985 273.0231555 419.7226414 1.53731518 0.620412976 0.170585416 1 4.147468404 6.650616898 64089 sorting nexin 16 "GO:0005764,GO:0005769,GO:0005770,GO:0005829,GO:0006622,GO:0008333,GO:0031313,GO:0031901,GO:0031902,GO:0035091,GO:0042802,GO:0043231,GO:0045022" lysosome|early endosome|late endosome|cytosol|protein targeting to lysosome|endosome to lysosome transport|extrinsic component of endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol binding|identical protein binding|intracellular membrane-bounded organelle|early endosome to late endosome transport SNX17 1605.496785 1549.837764 1661.155806 1.07182561 0.100070193 0.762180928 1 40.25323858 45.00294001 9784 sorting nexin 17 "GO:0001822,GO:0003279,GO:0005102,GO:0005515,GO:0005768,GO:0005769,GO:0005794,GO:0005829,GO:0006707,GO:0006886,GO:0006898,GO:0007165,GO:0008022,GO:0010008,GO:0016020,GO:0016197,GO:0030100,GO:0030659,GO:0031410,GO:0032456,GO:0032991,GO:0035091,GO:0035904,GO:0043231,GO:0050750,GO:0060976,GO:1990126" "kidney development|cardiac septum development|signaling receptor binding|protein binding|endosome|early endosome|Golgi apparatus|cytosol|cholesterol catabolic process|intracellular protein transport|receptor-mediated endocytosis|signal transduction|protein C-terminus binding|endosome membrane|membrane|endosomal transport|regulation of endocytosis|cytoplasmic vesicle membrane|cytoplasmic vesicle|endocytic recycling|protein-containing complex|phosphatidylinositol binding|aorta development|intracellular membrane-bounded organelle|low-density lipoprotein particle receptor binding|coronary vasculature development|retrograde transport, endosome to plasma membrane" SNX18 513.4101058 578.524902 448.2953095 0.774893713 -0.367929655 0.365222053 1 3.867508629 3.12600277 112574 sorting nexin 18 "GO:0000281,GO:0005515,GO:0005546,GO:0006897,GO:0010008,GO:0015031,GO:0016197,GO:0030136,GO:0030659,GO:0031234,GO:0031410,GO:0036089,GO:0043547,GO:0070062" "mitotic cytokinesis|protein binding|phosphatidylinositol-4,5-bisphosphate binding|endocytosis|endosome membrane|protein transport|endosomal transport|clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|cleavage furrow formation|positive regulation of GTPase activity|extracellular exosome" hsa05132 Salmonella infection SNX19 923.9033795 991.6119811 856.194778 0.863437306 -0.211836666 0.554329519 1 1.283718845 1.156156581 399979 sorting nexin 19 "GO:0002062,GO:0005515,GO:0005737,GO:0006887,GO:0030073,GO:0030659,GO:0031901,GO:0032266,GO:1990502" chondrocyte differentiation|protein binding|cytoplasm|exocytosis|insulin secretion|cytoplasmic vesicle membrane|early endosome membrane|phosphatidylinositol-3-phosphate binding|dense core granule maturation SNX2 1400.267592 1496.045097 1304.490088 0.871959067 -0.197667684 0.555198182 1 10.65074592 9.687061393 6643 sorting nexin 2 "GO:0005154,GO:0005158,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005829,GO:0006886,GO:0006897,GO:0010008,GO:0016020,GO:0030027,GO:0030904,GO:0030905,GO:0031901,GO:0032991,GO:0034498,GO:0035091,GO:0042147,GO:0042802,GO:0042803,GO:0045296,GO:0046982,GO:0072673,GO:1990459,GO:1990460" "epidermal growth factor receptor binding|insulin receptor binding|protein binding|cytoplasm|lysosome|endosome|cytosol|intracellular protein transport|endocytosis|endosome membrane|membrane|lamellipodium|retromer complex|retromer, tubulation complex|early endosome membrane|protein-containing complex|early endosome to Golgi transport|phosphatidylinositol binding|retrograde transport, endosome to Golgi|identical protein binding|protein homodimerization activity|cadherin binding|protein heterodimerization activity|lamellipodium morphogenesis|transferrin receptor binding|leptin receptor binding" hsa04144 Endocytosis SNX21 1420.692159 1646.258581 1195.125737 0.725964773 -0.46202855 0.166592053 1 16.77271967 12.70091371 90203 sorting nexin family member 21 "GO:0005546,GO:0015031,GO:0030659,GO:0031901,GO:0032266" "phosphatidylinositol-4,5-bisphosphate binding|protein transport|cytoplasmic vesicle membrane|early endosome membrane|phosphatidylinositol-3-phosphate binding" SNX22 36.0188127 37.55337083 34.48425458 0.918273215 -0.12300463 0.925633291 1 0.523519337 0.501441847 79856 sorting nexin 22 "GO:0015031,GO:0030659,GO:1901981" protein transport|cytoplasmic vesicle membrane|phosphatidylinositol phosphate binding SNX24 813.2907464 737.872989 888.7085037 1.204419347 0.268337788 0.464367398 1 6.394706337 8.033674994 28966 sorting nexin 24 "GO:0005515,GO:0015031,GO:0030659,GO:1901981" protein binding|protein transport|cytoplasmic vesicle membrane|phosphatidylinositol phosphate binding SNX25 477.1470797 423.2366388 531.0575205 1.254753185 0.327403608 0.429436248 1 1.798728092 2.354180476 83891 sorting nexin 25 "GO:0003674,GO:0010008,GO:0015031,GO:0030512,GO:0032801,GO:0035091,GO:0043231,GO:0060394" molecular_function|endosome membrane|protein transport|negative regulation of transforming growth factor beta receptor signaling pathway|receptor catabolic process|phosphatidylinositol binding|intracellular membrane-bounded organelle|negative regulation of pathway-restricted SMAD protein phosphorylation SNX27 878.3842619 843.4284097 913.3401141 1.082889909 0.114886581 0.752290088 1 5.723026998 6.464367398 81609 sorting nexin 27 "GO:0001770,GO:0001772,GO:0005515,GO:0005654,GO:0005768,GO:0005769,GO:0005829,GO:0006886,GO:0007165,GO:0008333,GO:0016197,GO:0030904,GO:0031901,GO:0032266,GO:0035091,GO:0071203,GO:1990126" "establishment of natural killer cell polarity|immunological synapse|protein binding|nucleoplasm|endosome|early endosome|cytosol|intracellular protein transport|signal transduction|endosome to lysosome transport|endosomal transport|retromer complex|early endosome membrane|phosphatidylinositol-3-phosphate binding|phosphatidylinositol binding|WASH complex|retrograde transport, endosome to plasma membrane" SNX29 306.6720873 354.219633 259.1245416 0.731536362 -0.450998518 0.337534588 1 1.304630558 0.995495713 92017 sorting nexin 29 GO:0035091 phosphatidylinositol binding SNX3 2645.596539 2604.377015 2686.816064 1.031654038 0.044959249 0.888884251 1 85.92997271 92.46868595 8724 sorting nexin 3 "GO:0005515,GO:0005737,GO:0005769,GO:0005829,GO:0009617,GO:0010008,GO:0010314,GO:0010324,GO:0010976,GO:0015031,GO:0016055,GO:0016579,GO:0019903,GO:0022615,GO:0030111,GO:0030136,GO:0030904,GO:0031901,GO:0032009,GO:0032266,GO:0032456,GO:0033157,GO:0034499,GO:0042177,GO:0046597,GO:0050765,GO:0051224,GO:0070062,GO:0070273,GO:0070676,GO:0080025,GO:2000642" "protein binding|cytoplasm|early endosome|cytosol|response to bacterium|endosome membrane|phosphatidylinositol-5-phosphate binding|membrane invagination|positive regulation of neuron projection development|protein transport|Wnt signaling pathway|protein deubiquitination|protein phosphatase binding|protein to membrane docking|regulation of Wnt signaling pathway|clathrin-coated vesicle|retromer complex|early endosome membrane|early phagosome|phosphatidylinositol-3-phosphate binding|endocytic recycling|regulation of intracellular protein transport|late endosome to Golgi transport|negative regulation of protein catabolic process|negative regulation of viral entry into host cell|negative regulation of phagocytosis|negative regulation of protein transport|extracellular exosome|phosphatidylinositol-4-phosphate binding|intralumenal vesicle formation|phosphatidylinositol-3,5-bisphosphate binding|negative regulation of early endosome to late endosome transport" hsa04144 Endocytosis SNX30 926.0535415 801.815215 1050.291868 1.309892664 0.389448598 0.275802263 1 4.906259757 6.7035087 401548 sorting nexin family member 30 "GO:0005515,GO:0015031,GO:0035091" protein binding|protein transport|phosphatidylinositol binding SNX33 1901.799348 1835.040391 1968.558304 1.072760204 0.101327624 0.755149027 1 21.47373433 24.02847229 257364 sorting nexin 33 "GO:0000281,GO:0005515,GO:0005829,GO:0006886,GO:0006897,GO:0007032,GO:0016020,GO:0016197,GO:0017038,GO:0019898,GO:0030659,GO:0031410,GO:0035091,GO:0036089,GO:0042802,GO:0044351,GO:0045806,GO:0051044,GO:0097320,GO:2000009,GO:2000010" mitotic cytokinesis|protein binding|cytosol|intracellular protein transport|endocytosis|endosome organization|membrane|endosomal transport|protein import|extrinsic component of membrane|cytoplasmic vesicle membrane|cytoplasmic vesicle|phosphatidylinositol binding|cleavage furrow formation|identical protein binding|macropinocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis|plasma membrane tubulation|negative regulation of protein localization to cell surface|positive regulation of protein localization to cell surface hsa05132 Salmonella infection SNX4 301.5082328 337.9803375 265.0361281 0.784176174 -0.350750286 0.459107192 1 6.54839777 5.356296686 8723 sorting nexin 4 "GO:0005154,GO:0005158,GO:0005515,GO:0005737,GO:0005868,GO:0005886,GO:0015031,GO:0016020,GO:0031201,GO:0031901,GO:0032456,GO:0032991,GO:0035091,GO:1903595,GO:1990459,GO:1990460" epidermal growth factor receptor binding|insulin receptor binding|protein binding|cytoplasm|cytoplasmic dynein complex|plasma membrane|protein transport|membrane|SNARE complex|early endosome membrane|endocytic recycling|protein-containing complex|phosphatidylinositol binding|positive regulation of histamine secretion by mast cell|transferrin receptor binding|leptin receptor binding hsa04144 Endocytosis SNX5 2900.389828 2813.457944 2987.321711 1.06179718 0.086508215 0.786487644 1 60.86788535 67.41331925 27131 sorting nexin 5 "GO:0001726,GO:0001891,GO:0005515,GO:0005768,GO:0005829,GO:0005903,GO:0006886,GO:0006907,GO:0007174,GO:0010314,GO:0016241,GO:0030659,GO:0030904,GO:0030905,GO:0031234,GO:0031313,GO:0031748,GO:0031901,GO:0034452,GO:0035091,GO:0035815,GO:0042147,GO:0043231,GO:0045296,GO:0045776,GO:0045893,GO:0046628,GO:0048471,GO:0070273,GO:0070685,GO:0080025,GO:0097422" "ruffle|phagocytic cup|protein binding|endosome|cytosol|brush border|intracellular protein transport|pinocytosis|epidermal growth factor catabolic process|phosphatidylinositol-5-phosphate binding|regulation of macroautophagy|cytoplasmic vesicle membrane|retromer complex|retromer, tubulation complex|extrinsic component of cytoplasmic side of plasma membrane|extrinsic component of endosome membrane|D1 dopamine receptor binding|early endosome membrane|dynactin binding|phosphatidylinositol binding|positive regulation of renal sodium excretion|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|cadherin binding|negative regulation of blood pressure|positive regulation of transcription, DNA-templated|positive regulation of insulin receptor signaling pathway|perinuclear region of cytoplasm|phosphatidylinositol-4-phosphate binding|macropinocytic cup|phosphatidylinositol-3,5-bisphosphate binding|tubular endosome" hsa04144 Endocytosis SNX6 1883.304732 1816.771183 1949.83828 1.073243729 0.101977744 0.753820508 1 26.76354021 29.9611066 58533 sorting nexin 6 "GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0006886,GO:0007175,GO:0016241,GO:0030512,GO:0030904,GO:0030905,GO:0031901,GO:0034452,GO:0035091,GO:0042147,GO:0042803,GO:0043524,GO:0045892,GO:0097422,GO:1903593,GO:1904646" "protein binding|nucleus|cytoplasm|endosome|cytosol|intracellular protein transport|negative regulation of epidermal growth factor-activated receptor activity|regulation of macroautophagy|negative regulation of transforming growth factor beta receptor signaling pathway|retromer complex|retromer, tubulation complex|early endosome membrane|dynactin binding|phosphatidylinositol binding|retrograde transport, endosome to Golgi|protein homodimerization activity|negative regulation of neuron apoptotic process|negative regulation of transcription, DNA-templated|tubular endosome|regulation of histamine secretion by mast cell|cellular response to amyloid-beta" hsa04144 Endocytosis SNX7 1039.95278 842.4134538 1237.492107 1.468984264 0.554818941 0.113313723 1 17.77719566 27.23932401 51375 sorting nexin 7 "GO:0005515,GO:0015031,GO:0030659,GO:0035091" protein binding|protein transport|cytoplasmic vesicle membrane|phosphatidylinositol binding SNX8 1159.493414 1268.69496 1050.291868 0.827852164 -0.272554938 0.428378474 1 11.44344151 9.881556814 29886 sorting nexin 8 "GO:0005515,GO:0005829,GO:0006886,GO:0030904,GO:0031901,GO:0034498,GO:0035091,GO:0042802,GO:0043231" protein binding|cytosol|intracellular protein transport|retromer complex|early endosome membrane|early endosome to Golgi transport|phosphatidylinositol binding|identical protein binding|intracellular membrane-bounded organelle SNX9 1570.320222 1435.147739 1705.492705 1.18837431 0.248989323 0.450450962 1 25.15928352 31.18655863 51429 sorting nexin 9 "GO:0000281,GO:0001726,GO:0005515,GO:0005545,GO:0005737,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006897,GO:0006898,GO:0016197,GO:0030136,GO:0030659,GO:0030838,GO:0031234,GO:0031410,GO:0031625,GO:0032437,GO:0035091,GO:0036089,GO:0042802,GO:0042803,GO:0043547,GO:0045296,GO:0045860,GO:0051044,GO:0060988,GO:0061024,GO:0065003,GO:0070062,GO:0071933,GO:0097320" mitotic cytokinesis|ruffle|protein binding|1-phosphatidylinositol binding|cytoplasm|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|endocytosis|receptor-mediated endocytosis|endosomal transport|clathrin-coated vesicle|cytoplasmic vesicle membrane|positive regulation of actin filament polymerization|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|ubiquitin protein ligase binding|cuticular plate|phosphatidylinositol binding|cleavage furrow formation|identical protein binding|protein homodimerization activity|positive regulation of GTPase activity|cadherin binding|positive regulation of protein kinase activity|positive regulation of membrane protein ectodomain proteolysis|lipid tube assembly|membrane organization|protein-containing complex assembly|extracellular exosome|Arp2/3 complex binding|plasma membrane tubulation hsa05132 Salmonella infection SOAT1 1511.796704 1677.722216 1345.871193 0.802201449 -0.317963522 0.337186594 1 11.59376608 9.701165319 6646 sterol O-acyltransferase 1 "GO:0000062,GO:0004772,GO:0005515,GO:0005783,GO:0005789,GO:0008203,GO:0008374,GO:0010742,GO:0010878,GO:0015485,GO:0016020,GO:0016021,GO:0033344,GO:0034379,GO:0034383,GO:0034435,GO:0034736,GO:0042632,GO:0042986" fatty-acyl-CoA binding|sterol O-acyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol metabolic process|O-acyltransferase activity|macrophage derived foam cell differentiation|cholesterol storage|cholesterol binding|membrane|integral component of membrane|cholesterol efflux|very-low-density lipoprotein particle assembly|low-density lipoprotein particle clearance|cholesterol esterification|cholesterol O-acyltransferase activity|cholesterol homeostasis|positive regulation of amyloid precursor protein biosynthetic process "hsa00100,hsa04979" Steroid biosynthesis|Cholesterol metabolism SOBP 54.72126924 70.03196182 39.41057666 0.562751287 -0.829430643 0.316749198 1 0.382247204 0.224376177 55084 sine oculis binding protein homolog "GO:0005634,GO:0007605,GO:0007626,GO:0032184,GO:0042472,GO:0046872,GO:0050890,GO:0090102" nucleus|sensory perception of sound|locomotory behavior|SUMO polymer binding|inner ear morphogenesis|metal ion binding|cognition|cochlea development SOCS1 92.23010274 142.0938356 42.36636991 0.298157691 -1.745852543 0.014190057 0.528014603 5.813046442 1.807863925 8651 suppressor of cytokine signaling 1 "GO:0001817,GO:0001932,GO:0004860,GO:0005159,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005942,GO:0006469,GO:0007259,GO:0010533,GO:0016567,GO:0019210,GO:0019221,GO:0019901,GO:0031410,GO:0035556,GO:0036464,GO:0038111,GO:0040008,GO:0042532,GO:0043372,GO:0043377,GO:0043551,GO:0045444,GO:0045591,GO:0046426,GO:0046627,GO:0046854,GO:0046935,GO:0060334,GO:0071230" "regulation of cytokine production|regulation of protein phosphorylation|protein kinase inhibitor activity|insulin-like growth factor receptor binding|protein binding|nucleoplasm|cytoplasm|cytosol|phosphatidylinositol 3-kinase complex|negative regulation of protein kinase activity|receptor signaling pathway via JAK-STAT|regulation of activation of Janus kinase activity|protein ubiquitination|kinase inhibitor activity|cytokine-mediated signaling pathway|protein kinase binding|cytoplasmic vesicle|intracellular signal transduction|cytoplasmic ribonucleoprotein granule|interleukin-7-mediated signaling pathway|regulation of growth|negative regulation of tyrosine phosphorylation of STAT protein|positive regulation of CD4-positive, alpha-beta T cell differentiation|negative regulation of CD8-positive, alpha-beta T cell differentiation|regulation of phosphatidylinositol 3-kinase activity|fat cell differentiation|positive regulation of regulatory T cell differentiation|negative regulation of receptor signaling pathway via JAK-STAT|negative regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|regulation of interferon-gamma-mediated signaling pathway|cellular response to amino acid stimulus" "hsa04120,hsa04380,hsa04630,hsa04910,hsa04917,hsa04930,hsa04935,hsa05145,hsa05206" "Ubiquitin mediated proteolysis|Osteoclast differentiation|JAK-STAT signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Type II diabetes mellitus|Growth hormone synthesis, secretion and action|Toxoplasmosis|MicroRNAs in cancer" SOCS2 327.1399534 338.9952934 315.2846133 0.93005602 -0.104610479 0.825795623 1 2.860532441 2.775057045 8835 suppressor of cytokine signaling 2 "GO:0001558,GO:0005131,GO:0005159,GO:0005515,GO:0005737,GO:0005829,GO:0005942,GO:0007259,GO:0007595,GO:0008269,GO:0009966,GO:0016567,GO:0032355,GO:0032870,GO:0035556,GO:0038111,GO:0040015,GO:0043066,GO:0043551,GO:0043687,GO:0045666,GO:0046426,GO:0046854,GO:0046935,GO:0060396,GO:0060749" regulation of cell growth|growth hormone receptor binding|insulin-like growth factor receptor binding|protein binding|cytoplasm|cytosol|phosphatidylinositol 3-kinase complex|receptor signaling pathway via JAK-STAT|lactation|JAK pathway signal transduction adaptor activity|regulation of signal transduction|protein ubiquitination|response to estradiol|cellular response to hormone stimulus|intracellular signal transduction|interleukin-7-mediated signaling pathway|negative regulation of multicellular organism growth|negative regulation of apoptotic process|regulation of phosphatidylinositol 3-kinase activity|post-translational protein modification|positive regulation of neuron differentiation|negative regulation of receptor signaling pathway via JAK-STAT|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|growth hormone receptor signaling pathway|mammary gland alveolus development "hsa04630,hsa04910,hsa04917,hsa04930,hsa04935" "JAK-STAT signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Type II diabetes mellitus|Growth hormone synthesis, secretion and action" SOCS3 164.5376737 201.9762377 127.0991097 0.629277539 -0.668231646 0.245419665 1 3.618459112 2.375099617 9021 suppressor of cytokine signaling 3 "GO:0001784,GO:0004860,GO:0005515,GO:0005829,GO:0005942,GO:0006469,GO:0007259,GO:0016567,GO:0019221,GO:0035556,GO:0040008,GO:0042531,GO:0042532,GO:0043066,GO:0043551,GO:0043687,GO:0045597,GO:0046426,GO:0046627,GO:0046854,GO:0046935,GO:0050728,GO:0060334,GO:0060670,GO:0060674,GO:0060707,GO:0070102,GO:1990830" phosphotyrosine residue binding|protein kinase inhibitor activity|protein binding|cytosol|phosphatidylinositol 3-kinase complex|negative regulation of protein kinase activity|receptor signaling pathway via JAK-STAT|protein ubiquitination|cytokine-mediated signaling pathway|intracellular signal transduction|regulation of growth|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|negative regulation of apoptotic process|regulation of phosphatidylinositol 3-kinase activity|post-translational protein modification|positive regulation of cell differentiation|negative regulation of receptor signaling pathway via JAK-STAT|negative regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|negative regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|branching involved in labyrinthine layer morphogenesis|placenta blood vessel development|trophoblast giant cell differentiation|interleukin-6-mediated signaling pathway|cellular response to leukemia inhibitory factor "hsa04120,hsa04380,hsa04630,hsa04668,hsa04910,hsa04917,hsa04920,hsa04930,hsa04931,hsa04932,hsa04935,hsa05160,hsa05164,hsa05168" "Ubiquitin mediated proteolysis|Osteoclast differentiation|JAK-STAT signaling pathway|TNF signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|Growth hormone synthesis, secretion and action|Hepatitis C|Influenza A|Herpes simplex virus 1 infection" SOCS4 1067.918009 969.2829498 1166.553069 1.203521706 0.267262161 0.443591549 1 6.946478277 8.720362506 122809 suppressor of cytokine signaling 4 "GO:0005515,GO:0005942,GO:0007175,GO:0016567,GO:0032436,GO:0035556,GO:0040008,GO:0043551,GO:0046854,GO:0046935" protein binding|phosphatidylinositol 3-kinase complex|negative regulation of epidermal growth factor-activated receptor activity|protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|intracellular signal transduction|regulation of growth|regulation of phosphatidylinositol 3-kinase activity|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity "hsa04630,hsa04910,hsa04917,hsa04930" JAK-STAT signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Type II diabetes mellitus SOCS5 466.4576288 433.3861985 499.5290592 1.152618752 0.204915396 0.624693001 1 4.442315738 5.340858025 9655 suppressor of cytokine signaling 5 "GO:0005154,GO:0005515,GO:0005829,GO:0005942,GO:0007173,GO:0007175,GO:0007259,GO:0009968,GO:0016567,GO:0019221,GO:0030971,GO:0032436,GO:0032715,GO:0035556,GO:0040008,GO:0043551,GO:0043687,GO:0045627,GO:0045629,GO:0046854,GO:0046935,GO:0050728,GO:0071404,GO:0071638,GO:0097699" epidermal growth factor receptor binding|protein binding|cytosol|phosphatidylinositol 3-kinase complex|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor-activated receptor activity|receptor signaling pathway via JAK-STAT|negative regulation of signal transduction|protein ubiquitination|cytokine-mediated signaling pathway|receptor tyrosine kinase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of interleukin-6 production|intracellular signal transduction|regulation of growth|regulation of phosphatidylinositol 3-kinase activity|post-translational protein modification|positive regulation of T-helper 1 cell differentiation|negative regulation of T-helper 2 cell differentiation|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|negative regulation of inflammatory response|cellular response to low-density lipoprotein particle stimulus|negative regulation of monocyte chemotactic protein-1 production|vascular endothelial cell response to fluid shear stress "hsa04630,hsa04917" JAK-STAT signaling pathway|Prolactin signaling pathway SOCS6 1305.308342 1504.164745 1106.45194 0.735592257 -0.443021801 0.18984018 1 12.32496974 9.456685382 9306 suppressor of cytokine signaling 6 "GO:0001772,GO:0005515,GO:0005737,GO:0005829,GO:0005942,GO:0006952,GO:0007259,GO:0009968,GO:0010498,GO:0016567,GO:0035556,GO:0040008,GO:0043551,GO:0043687,GO:0046854,GO:0046935,GO:0050868" immunological synapse|protein binding|cytoplasm|cytosol|phosphatidylinositol 3-kinase complex|defense response|receptor signaling pathway via JAK-STAT|negative regulation of signal transduction|proteasomal protein catabolic process|protein ubiquitination|intracellular signal transduction|regulation of growth|regulation of phosphatidylinositol 3-kinase activity|post-translational protein modification|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|negative regulation of T cell activation "hsa04630,hsa04917" JAK-STAT signaling pathway|Prolactin signaling pathway SOCS7 848.5321355 789.6357434 907.4285276 1.149173572 0.20059672 0.581911966 1 4.842851143 5.805006088 30837 suppressor of cytokine signaling 7 "GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005942,GO:0008150,GO:0009968,GO:0016567,GO:0017124,GO:0035556,GO:0040008,GO:0043551,GO:0046854,GO:0046935" protein binding|nucleus|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|biological_process|negative regulation of signal transduction|protein ubiquitination|SH3 domain binding|intracellular signal transduction|regulation of growth|regulation of phosphatidylinositol 3-kinase activity|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity "hsa04630,hsa04917" JAK-STAT signaling pathway|Prolactin signaling pathway SOD1 2218.398308 2194.334804 2242.461812 1.021932391 0.031299753 0.923551749 1 124.1735382 132.3631671 6647 superoxide dismutase 1 "GO:0000187,GO:0000303,GO:0001541,GO:0001819,GO:0001890,GO:0001895,GO:0001975,GO:0002262,GO:0002576,GO:0004784,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005758,GO:0005759,GO:0005764,GO:0005777,GO:0005829,GO:0005886,GO:0006749,GO:0006801,GO:0006879,GO:0007283,GO:0007566,GO:0007569,GO:0007605,GO:0007626,GO:0008089,GO:0008090,GO:0008217,GO:0008270,GO:0009408,GO:0010033,GO:0019226,GO:0019430,GO:0030346,GO:0031045,GO:0031267,GO:0031410,GO:0031667,GO:0032287,GO:0032839,GO:0032930,GO:0032991,GO:0033081,GO:0034465,GO:0034599,GO:0035722,GO:0035865,GO:0040014,GO:0042493,GO:0042542,GO:0042554,GO:0042802,GO:0043025,GO:0043065,GO:0043085,GO:0043087,GO:0043524,GO:0045471,GO:0045541,GO:0045859,GO:0046620,GO:0046677,GO:0046688,GO:0046716,GO:0048538,GO:0048678,GO:0050665,GO:0050728,GO:0050766,GO:0051087,GO:0051881,GO:0055114,GO:0060047,GO:0060052,GO:0060087,GO:0060088,GO:0070062,GO:0071276,GO:0071318,GO:0072593,GO:0097332,GO:1902177,GO:1904115" activation of MAPK activity|response to superoxide|ovarian follicle development|positive regulation of cytokine production|placenta development|retina homeostasis|response to amphetamine|myeloid cell homeostasis|platelet degranulation|superoxide dismutase activity|copper ion binding|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|lysosome|peroxisome|cytosol|plasma membrane|glutathione metabolic process|superoxide metabolic process|cellular iron ion homeostasis|spermatogenesis|embryo implantation|cell aging|sensory perception of sound|locomotory behavior|anterograde axonal transport|retrograde axonal transport|regulation of blood pressure|zinc ion binding|response to heat|response to organic substance|transmission of nerve impulse|removal of superoxide radicals|protein phosphatase 2B binding|dense core granule|small GTPase binding|cytoplasmic vesicle|response to nutrient levels|peripheral nervous system myelin maintenance|dendrite cytoplasm|positive regulation of superoxide anion generation|protein-containing complex|regulation of T cell differentiation in thymus|response to carbon monoxide|cellular response to oxidative stress|interleukin-12-mediated signaling pathway|cellular response to potassium ion|regulation of multicellular organism growth|response to drug|response to hydrogen peroxide|superoxide anion generation|identical protein binding|neuronal cell body|positive regulation of apoptotic process|positive regulation of catalytic activity|regulation of GTPase activity|negative regulation of neuron apoptotic process|response to ethanol|negative regulation of cholesterol biosynthetic process|regulation of protein kinase activity|regulation of organ growth|response to antibiotic|response to copper ion|muscle cell cellular homeostasis|thymus development|response to axon injury|hydrogen peroxide biosynthetic process|negative regulation of inflammatory response|positive regulation of phagocytosis|chaperone binding|regulation of mitochondrial membrane potential|oxidation-reduction process|heart contraction|neurofilament cytoskeleton organization|relaxation of vascular associated smooth muscle|auditory receptor cell stereocilium organization|extracellular exosome|cellular response to cadmium ion|cellular response to ATP|reactive oxygen species metabolic process|response to antipsychotic drug|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|axon cytoplasm "hsa04146,hsa04213,hsa05014,hsa05016,hsa05020,hsa05022" Peroxisome|Longevity regulating pathway - multiple species|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases SOD2 15362.44622 14765.57943 15959.31302 1.080845699 0.112160579 0.749634103 1 42.50935131 47.925219 6648 superoxide dismutase 2 "GO:0000303,GO:0001315,GO:0001666,GO:0001836,GO:0003069,GO:0003677,GO:0004784,GO:0005515,GO:0005739,GO:0005759,GO:0006357,GO:0006801,GO:0008217,GO:0008285,GO:0009314,GO:0009409,GO:0010042,GO:0010043,GO:0010269,GO:0010729,GO:0014823,GO:0019430,GO:0019825,GO:0019899,GO:0030145,GO:0030335,GO:0032364,GO:0032496,GO:0033591,GO:0034021,GO:0034599,GO:0035722,GO:0035900,GO:0035902,GO:0042493,GO:0042542,GO:0042645,GO:0042802,GO:0043524,GO:0046686,GO:0050665,GO:0051289,GO:0051602,GO:0055114,GO:0070062,GO:0071000,GO:0071361,GO:1902176,GO:1902631,GO:1904706,GO:1905461,GO:1905932" response to superoxide|age-dependent response to reactive oxygen species|response to hypoxia|release of cytochrome c from mitochondria|acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure|DNA binding|superoxide dismutase activity|protein binding|mitochondrion|mitochondrial matrix|regulation of transcription by RNA polymerase II|superoxide metabolic process|regulation of blood pressure|negative regulation of cell population proliferation|response to radiation|response to cold|response to manganese ion|response to zinc ion|response to selenium ion|positive regulation of hydrogen peroxide biosynthetic process|response to activity|removal of superoxide radicals|oxygen binding|enzyme binding|manganese ion binding|positive regulation of cell migration|oxygen homeostasis|response to lipopolysaccharide|response to L-ascorbic acid|response to silicon dioxide|cellular response to oxidative stress|interleukin-12-mediated signaling pathway|response to isolation stress|response to immobilization stress|response to drug|response to hydrogen peroxide|mitochondrial nucleoid|identical protein binding|negative regulation of neuron apoptotic process|response to cadmium ion|hydrogen peroxide biosynthetic process|protein homotetramerization|response to electrical stimulus|oxidation-reduction process|extracellular exosome|response to magnetism|cellular response to ethanol|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of membrane hyperpolarization|negative regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell apoptotic process|positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching "hsa04068,hsa04146,hsa04211,hsa04213,hsa05016" FoxO signaling pathway|Peroxisome|Longevity regulating pathway|Longevity regulating pathway - multiple species|Huntington disease SOGA1 1928.855025 1765.008429 2092.701621 1.185660978 0.245691552 0.447275483 1 15.64976372 19.35460184 140710 "suppressor of glucose, autophagy associated 1" "GO:0003674,GO:0005615,GO:0008286,GO:0010506,GO:0045721,GO:0070062" molecular_function|extracellular space|insulin receptor signaling pathway|regulation of autophagy|negative regulation of gluconeogenesis|extracellular exosome SOGA3 201.2799701 154.2733072 248.286633 1.609394635 0.686518129 0.202429154 1 0.680194896 1.141857339 387104 SOGA family member 3 "GO:0005615,GO:0010506,GO:0016021" extracellular space|regulation of autophagy|integral component of membrane SON 9173.570619 9583.214253 8763.926985 0.914508092 -0.128932159 0.699630275 1 45.33918677 43.24911337 6651 SON DNA and RNA binding protein "GO:0000226,GO:0000281,GO:0003677,GO:0003723,GO:0005515,GO:0006397,GO:0008380,GO:0016607,GO:0043066,GO:0043484,GO:0048024,GO:0051726" "microtubule cytoskeleton organization|mitotic cytokinesis|DNA binding|RNA binding|protein binding|mRNA processing|RNA splicing|nuclear speck|negative regulation of apoptotic process|regulation of RNA splicing|regulation of mRNA splicing, via spliceosome|regulation of cell cycle" SORBS1 1624.408074 2135.467357 1113.348791 0.521360716 -0.939646213 0.004482239 0.246960457 11.24611502 6.115849016 10580 sorbin and SH3 domain containing 1 "GO:0001725,GO:0003779,GO:0005158,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0005886,GO:0005912,GO:0005915,GO:0005925,GO:0006936,GO:0007160,GO:0008092,GO:0008286,GO:0016363,GO:0030055,GO:0030159,GO:0032869,GO:0043149,GO:0045121,GO:0045725,GO:0046326,GO:0046628,GO:0046889,GO:0048041,GO:1903078" stress fiber|actin binding|insulin receptor binding|protein binding|nucleus|centrosome|cytosol|plasma membrane|adherens junction|zonula adherens|focal adhesion|muscle contraction|cell-matrix adhesion|cytoskeletal protein binding|insulin receptor signaling pathway|nuclear matrix|cell-substrate junction|signaling receptor complex adaptor activity|cellular response to insulin stimulus|stress fiber assembly|membrane raft|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|positive regulation of insulin receptor signaling pathway|positive regulation of lipid biosynthetic process|focal adhesion assembly|positive regulation of protein localization to plasma membrane "hsa03320,hsa04520,hsa04910" PPAR signaling pathway|Adherens junction|Insulin signaling pathway SORBS2 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.013758348 0.002786235 8470 sorbin and SH3 domain containing 2 "GO:0003723,GO:0005200,GO:0005515,GO:0005634,GO:0005886,GO:0005925,GO:0007015,GO:0007219,GO:0008093,GO:0008150,GO:0008307,GO:0015629,GO:0016324,GO:0030018,GO:0030027,GO:0048471,GO:0061049" RNA binding|structural constituent of cytoskeleton|protein binding|nucleus|plasma membrane|focal adhesion|actin filament organization|Notch signaling pathway|cytoskeletal anchor activity|biological_process|structural constituent of muscle|actin cytoskeleton|apical plasma membrane|Z disc|lamellipodium|perinuclear region of cytoplasm|cell growth involved in cardiac muscle cell development SORBS3 1367.166963 1186.483527 1547.850398 1.304569649 0.38357397 0.253187232 1 15.48742396 21.07474786 10174 sorbin and SH3 domain containing 3 "GO:0000122,GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0005925,GO:0006936,GO:0007015,GO:0007155,GO:0008134,GO:0017166,GO:0031589,GO:0043410,GO:0051495,GO:0051496" negative regulation of transcription by RNA polymerase II|structural constituent of cytoskeleton|protein binding|nucleus|cytosol|cytoskeleton|focal adhesion|muscle contraction|actin filament organization|cell adhesion|transcription factor binding|vinculin binding|cell-substrate adhesion|positive regulation of MAPK cascade|positive regulation of cytoskeleton organization|positive regulation of stress fiber assembly SORCS2 897.1119585 1483.865626 310.3582912 0.209155254 -2.257353859 2.07E-09 1.56E-06 14.19579886 3.097023813 57537 sortilin related VPS10 domain containing receptor 2 "GO:0005887,GO:0006886,GO:0007218,GO:0008188,GO:0016020,GO:0016021,GO:0030659,GO:0031901,GO:0043197,GO:0043204,GO:0055038,GO:0060292,GO:0098839" integral component of plasma membrane|intracellular protein transport|neuropeptide signaling pathway|neuropeptide receptor activity|membrane|integral component of membrane|cytoplasmic vesicle membrane|early endosome membrane|dendritic spine|perikaryon|recycling endosome membrane|long-term synaptic depression|postsynaptic density membrane SORD 336.1206561 414.1020351 258.1392771 0.623371187 -0.681836622 0.135645767 1 4.353011045 2.830430031 6652 sorbitol dehydrogenase "GO:0000721,GO:0003939,GO:0005615,GO:0005829,GO:0006006,GO:0006062,GO:0006970,GO:0008270,GO:0009725,GO:0016020,GO:0019640,GO:0030246,GO:0030317,GO:0031514,GO:0031667,GO:0031966,GO:0042493,GO:0042802,GO:0046370,GO:0046526,GO:0046686,GO:0046688,GO:0050255,GO:0051160,GO:0051164,GO:0051287,GO:0055114,GO:0070062" "(R,R)-butanediol dehydrogenase activity|L-iditol 2-dehydrogenase activity|extracellular space|cytosol|glucose metabolic process|sorbitol catabolic process|response to osmotic stress|zinc ion binding|response to hormone|membrane|glucuronate catabolic process to xylulose 5-phosphate|carbohydrate binding|flagellated sperm motility|motile cilium|response to nutrient levels|mitochondrial membrane|response to drug|identical protein binding|fructose biosynthetic process|D-xylulose reductase activity|response to cadmium ion|response to copper ion|ribitol 2-dehydrogenase activity|L-xylitol catabolic process|L-xylitol metabolic process|NAD binding|oxidation-reduction process|extracellular exosome" "hsa00040,hsa00051" Pentose and glucuronate interconversions|Fructose and mannose metabolism SORL1 271.8639472 298.3970547 245.3308397 0.822162404 -0.282504694 0.565454776 1 1.391214042 1.193074313 6653 sortilin related receptor 1 "GO:0000139,GO:0001540,GO:0002024,GO:0004888,GO:0005041,GO:0005515,GO:0005615,GO:0005641,GO:0005768,GO:0005769,GO:0005771,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0006605,GO:0006622,GO:0006892,GO:0006898,GO:0007218,GO:0009986,GO:0010008,GO:0010897,GO:0014910,GO:0016020,GO:0016021,GO:0030169,GO:0030514,GO:0030658,GO:0031267,GO:0031333,GO:0031901,GO:0031985,GO:0032091,GO:0032585,GO:0034067,GO:0038020,GO:0042923,GO:0043407,GO:0044267,GO:0045053,GO:0045732,GO:0046628,GO:0050768,GO:0051604,GO:0055037,GO:0055038,GO:0070062,GO:0070863,GO:0097356,GO:1900168,GO:1901215,GO:1902430,GO:1902771,GO:1902948,GO:1902953,GO:1902955,GO:1902960,GO:1902963,GO:1902966,GO:1902997,GO:1904179,GO:1990845,GO:2001137" Golgi membrane|amyloid-beta binding|diet induced thermogenesis|transmembrane signaling receptor activity|low-density lipoprotein particle receptor activity|protein binding|extracellular space|nuclear envelope lumen|endosome|early endosome|multivesicular body|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|protein targeting|protein targeting to lysosome|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|neuropeptide signaling pathway|cell surface|endosome membrane|negative regulation of triglyceride catabolic process|regulation of smooth muscle cell migration|membrane|integral component of membrane|low-density lipoprotein particle binding|negative regulation of BMP signaling pathway|transport vesicle membrane|small GTPase binding|negative regulation of protein-containing complex assembly|early endosome membrane|Golgi cisterna|negative regulation of protein binding|multivesicular body membrane|protein localization to Golgi apparatus|insulin receptor recycling|neuropeptide binding|negative regulation of MAP kinase activity|cellular protein metabolic process|protein retention in Golgi apparatus|positive regulation of protein catabolic process|positive regulation of insulin receptor signaling pathway|negative regulation of neurogenesis|protein maturation|recycling endosome|recycling endosome membrane|extracellular exosome|positive regulation of protein exit from endoplasmic reticulum|perinucleolar compartment|positive regulation of glial cell-derived neurotrophic factor production|negative regulation of neuron death|negative regulation of amyloid-beta formation|positive regulation of choline O-acetyltransferase activity|negative regulation of tau-protein kinase activity|positive regulation of ER to Golgi vesicle-mediated transport|positive regulation of early endosome to recycling endosome transport|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of protein localization to early endosome|negative regulation of neurofibrillary tangle assembly|positive regulation of adipose tissue development|adaptive thermogenesis|positive regulation of endocytic recycling SORT1 3607.352927 3657.90131 3556.804544 0.972362085 -0.040434455 0.899684864 1 23.20097646 23.53153237 6272 sortilin 1 "GO:0001503,GO:0005515,GO:0005764,GO:0005765,GO:0005769,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0005905,GO:0006622,GO:0006892,GO:0006895,GO:0006897,GO:0007186,GO:0007218,GO:0007275,GO:0008333,GO:0008625,GO:0009986,GO:0010008,GO:0010465,GO:0010468,GO:0014902,GO:0016021,GO:0016050,GO:0019899,GO:0030136,GO:0030140,GO:0030379,GO:0030425,GO:0030659,GO:0031410,GO:0031965,GO:0032509,GO:0032580,GO:0032868,GO:0038180,GO:0043025,GO:0045599,GO:0046323,GO:0048011,GO:0048227,GO:0048406,GO:0048471,GO:0051005,GO:0090160,GO:1904037,GO:1905394" "ossification|protein binding|lysosome|lysosomal membrane|early endosome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|clathrin-coated pit|protein targeting to lysosome|post-Golgi vesicle-mediated transport|Golgi to endosome transport|endocytosis|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|multicellular organism development|endosome to lysosome transport|extrinsic apoptotic signaling pathway via death domain receptors|cell surface|endosome membrane|nerve growth factor receptor activity|regulation of gene expression|myotube differentiation|integral component of membrane|vesicle organization|enzyme binding|clathrin-coated vesicle|trans-Golgi network transport vesicle|neurotensin receptor activity, non-G protein-coupled|dendrite|cytoplasmic vesicle membrane|cytoplasmic vesicle|nuclear membrane|endosome transport via multivesicular body sorting pathway|Golgi cisterna membrane|response to insulin|nerve growth factor signaling pathway|neuronal cell body|negative regulation of fat cell differentiation|glucose import|neurotrophin TRK receptor signaling pathway|plasma membrane to endosome transport|nerve growth factor binding|perinuclear region of cytoplasm|negative regulation of lipoprotein lipase activity|Golgi to lysosome transport|positive regulation of epithelial cell apoptotic process|retromer complex binding" "hsa04142,hsa04722,hsa04979" Lysosome|Neurotrophin signaling pathway|Cholesterol metabolism SOS1 1271.379071 1104.272094 1438.486048 1.302655438 0.381455531 0.260749918 1 6.114298229 8.307916149 6654 SOS Ras/Rac guanine nucleotide exchange factor 1 "GO:0000165,GO:0001782,GO:0001942,GO:0003209,GO:0003344,GO:0003677,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0007173,GO:0007186,GO:0007265,GO:0007296,GO:0007411,GO:0008286,GO:0014069,GO:0017124,GO:0019221,GO:0033081,GO:0035264,GO:0038095,GO:0038128,GO:0042129,GO:0043025,GO:0043065,GO:0043547,GO:0045742,GO:0046982,GO:0048011,GO:0048514,GO:0050900,GO:0051056,GO:0051057,GO:0060021,GO:0061029,GO:0061384,GO:1904693,GO:2000973" MAPK cascade|B cell homeostasis|hair follicle development|cardiac atrium morphogenesis|pericardium morphogenesis|DNA binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|signal transduction|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|Ras protein signal transduction|vitellogenesis|axon guidance|insulin receptor signaling pathway|postsynaptic density|SH3 domain binding|cytokine-mediated signaling pathway|regulation of T cell differentiation in thymus|multicellular organism growth|Fc-epsilon receptor signaling pathway|ERBB2 signaling pathway|regulation of T cell proliferation|neuronal cell body|positive regulation of apoptotic process|positive regulation of GTPase activity|positive regulation of epidermal growth factor receptor signaling pathway|protein heterodimerization activity|neurotrophin TRK receptor signaling pathway|blood vessel morphogenesis|leukocyte migration|regulation of small GTPase mediated signal transduction|positive regulation of small GTPase mediated signal transduction|roof of mouth development|eyelid development in camera-type eye|heart trabecula morphogenesis|midbrain morphogenesis|regulation of pro-B cell differentiation "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04062,hsa04068,hsa04072,hsa04150,hsa04151,hsa04510,hsa04540,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04722,hsa04810,hsa04910,hsa04912,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05231" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer" SOS2 958.5524215 800.800259 1116.304584 1.393986292 0.479216375 0.177277313 1 7.363418313 10.7066574 6655 SOS Ras/Rho guanine nucleotide exchange factor 2 "GO:0001782,GO:0003677,GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0007264,GO:0033081,GO:0042129,GO:0043065,GO:0046982,GO:0050790,GO:0051056,GO:0051057,GO:2000973" B cell homeostasis|DNA binding|guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|regulation of T cell differentiation in thymus|regulation of T cell proliferation|positive regulation of apoptotic process|protein heterodimerization activity|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|positive regulation of small GTPase mediated signal transduction|regulation of pro-B cell differentiation "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04062,hsa04068,hsa04072,hsa04150,hsa04151,hsa04510,hsa04540,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04722,hsa04810,hsa04910,hsa04912,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05231" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer" SOWAHA 13.46437316 11.16451565 15.76423066 1.411994139 0.4977341 0.73348906 1 0.162250597 0.238965457 134548 sosondowah ankyrin repeat domain family member A SOWAHB 47.4681197 45.67301858 49.26322083 1.078606634 0.109168812 0.924091403 1 0.579308106 0.651761379 345079 sosondowah ankyrin repeat domain family member B GO:0005515 protein binding SOWAHC 415.8649691 443.5357582 388.1941801 0.875226344 -0.192271931 0.656943533 1 4.854878204 4.432152042 65124 sosondowah ankyrin repeat domain family member C SOWAHD 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.222803452 0.128915576 347454 sosondowah ankyrin repeat domain family member D SOX12 1581.083656 1800.531888 1361.635424 0.75624066 -0.403082675 0.221276948 1 19.51435656 15.39324529 6666 SRY-box transcription factor 12 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0005654,GO:0006355,GO:0009653,GO:0021510,GO:0030154,GO:0032993,GO:0045165,GO:0045591,GO:0045944,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nucleoplasm|regulation of transcription, DNA-templated|anatomical structure morphogenesis|spinal cord development|cell differentiation|protein-DNA complex|cell fate commitment|positive regulation of regulatory T cell differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" SOX13 658.4936316 629.2727004 687.7145627 1.092872076 0.12812454 0.740502947 1 7.782769801 8.87195733 9580 SRY-box transcription factor 13 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001217,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0009653,GO:0021529,GO:0042492,GO:0042802,GO:0043565,GO:0045165,GO:0045588,GO:0045892,GO:0090090,GO:0090336" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|spinal cord oligodendrocyte cell differentiation|gamma-delta T cell differentiation|identical protein binding|sequence-specific DNA binding|cell fate commitment|positive regulation of gamma-delta T cell differentiation|negative regulation of transcription, DNA-templated|negative regulation of canonical Wnt signaling pathway|positive regulation of brown fat cell differentiation" SOX18 80.87531361 73.07682972 88.67379749 1.213432463 0.279093814 0.711876793 1 1.987692603 2.515826925 54345 SRY-box transcription factor 18 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0001570,GO:0001701,GO:0001942,GO:0001944,GO:0001946,GO:0001947,GO:0003151,GO:0005634,GO:0005667,GO:0006355,GO:0009653,GO:0022405,GO:0030154,GO:0035050,GO:0043534,GO:0045892,GO:0045893,GO:0045944,GO:0048469,GO:0048866,GO:0060214,GO:0060836,GO:0060956,GO:0061028,GO:0072091,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|vasculogenesis|in utero embryonic development|hair follicle development|vasculature development|lymphangiogenesis|heart looping|outflow tract morphogenesis|nucleus|transcription regulator complex|regulation of transcription, DNA-templated|anatomical structure morphogenesis|hair cycle process|cell differentiation|embryonic heart tube development|blood vessel endothelial cell migration|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell maturation|stem cell fate specification|endocardium formation|lymphatic endothelial cell differentiation|endocardial cell differentiation|establishment of endothelial barrier|regulation of stem cell proliferation|sequence-specific double-stranded DNA binding" SOX4 298.8317876 390.7580478 206.9055275 0.529497802 -0.917303399 0.053527868 1 4.06459573 2.244902316 6659 SRY-box transcription factor 4 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0001841,GO:0002328,GO:0003183,GO:0003211,GO:0003215,GO:0003289,GO:0003357,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005739,GO:0006355,GO:0006977,GO:0007507,GO:0008284,GO:0008285,GO:0009653,GO:0014009,GO:0021510,GO:0021522,GO:0021782,GO:0030154,GO:0030217,GO:0031018,GO:0031397,GO:0031647,GO:0032024,GO:0035019,GO:0035198,GO:0035910,GO:0042593,GO:0042769,GO:0043065,GO:0045588,GO:0045727,GO:0045893,GO:0045944,GO:0048485,GO:0050821,GO:0060174,GO:0060412,GO:0060548,GO:0060563,GO:0060993,GO:0061484,GO:0071333,GO:0090263,GO:1990837,GO:2000761" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|neural tube formation|pro-B cell differentiation|mitral valve morphogenesis|cardiac ventricle formation|cardiac right ventricle morphogenesis|atrial septum primum morphogenesis|noradrenergic neuron differentiation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|mitochondrion|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|heart development|positive regulation of cell population proliferation|negative regulation of cell population proliferation|anatomical structure morphogenesis|glial cell proliferation|spinal cord development|spinal cord motor neuron differentiation|glial cell development|cell differentiation|T cell differentiation|endocrine pancreas development|negative regulation of protein ubiquitination|regulation of protein stability|positive regulation of insulin secretion|somatic stem cell population maintenance|miRNA binding|ascending aorta morphogenesis|glucose homeostasis|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|positive regulation of gamma-delta T cell differentiation|positive regulation of translation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|sympathetic nervous system development|protein stabilization|limb bud formation|ventricular septum morphogenesis|negative regulation of cell death|neuroepithelial cell differentiation|kidney morphogenesis|hematopoietic stem cell homeostasis|cellular response to glucose stimulus|positive regulation of canonical Wnt signaling pathway|sequence-specific double-stranded DNA binding|positive regulation of N-terminal peptidyl-lysine acetylation" hsa05206 MicroRNAs in cancer HMG SOX5 82.86068822 74.09178569 91.62959074 1.236703771 0.306499971 0.680592946 1 0.230171598 0.296915827 6660 SRY-box transcription factor 5 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001502,GO:0002062,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0032332,GO:0045165,GO:0051216,GO:0055059,GO:0061036,GO:0071560,GO:2000741" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cartilage condensation|chondrocyte differentiation|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|positive regulation of chondrocyte differentiation|cell fate commitment|cartilage development|asymmetric neuroblast division|positive regulation of cartilage development|cellular response to transforming growth factor beta stimulus|positive regulation of mesenchymal stem cell differentiation" SOX7 516.0771483 457.7451417 574.4091548 1.254866742 0.327534169 0.419951814 1 7.2109414 9.438554881 83595 SRY-box transcription factor 7 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001706,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0008285,GO:0009653,GO:0030154,GO:0043280,GO:0045892,GO:0045893,GO:0060828,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|endoderm formation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|negative regulation of cell population proliferation|anatomical structure morphogenesis|cell differentiation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of canonical Wnt signaling pathway|sequence-specific double-stranded DNA binding" SOX9 2487.771878 2827.667328 2147.876428 0.759593042 -0.396701404 0.214001151 1 36.43128332 28.86498776 6662 SRY-box transcription factor 9 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0001501,GO:0001502,GO:0001503,GO:0001658,GO:0001708,GO:0001837,GO:0001894,GO:0001934,GO:0001942,GO:0002009,GO:0002053,GO:0002062,GO:0002683,GO:0003170,GO:0003179,GO:0003180,GO:0003188,GO:0003203,GO:0003413,GO:0003415,GO:0003430,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006334,GO:0006338,GO:0006357,GO:0006367,GO:0007010,GO:0007165,GO:0007173,GO:0007219,GO:0007283,GO:0007507,GO:0008013,GO:0008284,GO:0008584,GO:0010564,GO:0010628,GO:0010634,GO:0014032,GO:0014036,GO:0014068,GO:0019100,GO:0019933,GO:0030155,GO:0030198,GO:0030279,GO:0030502,GO:0030850,GO:0030857,GO:0030858,GO:0030879,GO:0030903,GO:0030916,GO:0031018,GO:0032331,GO:0032332,GO:0032808,GO:0032991,GO:0034236,GO:0034504,GO:0035019,GO:0035622,GO:0042127,GO:0042981,GO:0043066,GO:0043425,GO:0043491,GO:0043565,GO:0045662,GO:0045668,GO:0045732,GO:0045892,GO:0045893,GO:0045944,GO:0046322,GO:0046533,GO:0048709,GO:0050679,GO:0050680,GO:0051216,GO:0060008,GO:0060009,GO:0060018,GO:0060041,GO:0060174,GO:0060221,GO:0060441,GO:0060487,GO:0060517,GO:0060532,GO:0060534,GO:0060729,GO:0060784,GO:0061036,GO:0061046,GO:0061138,GO:0061145,GO:0065003,GO:0070168,GO:0070371,GO:0070384,GO:0070542,GO:0071260,GO:0071300,GO:0071347,GO:0071364,GO:0071504,GO:0071560,GO:0071773,GO:0072034,GO:0072190,GO:0072193,GO:0072197,GO:0072289,GO:0090090,GO:0090103,GO:0090184,GO:0090190,GO:0097065,GO:0097157,GO:0098609,GO:1901203,GO:1902732,GO:1902894,GO:1904864,GO:1990837,GO:2000020,GO:2000138,GO:2000741,GO:2000794,GO:2001054" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|cartilage condensation|ossification|branching involved in ureteric bud morphogenesis|cell fate specification|epithelial to mesenchymal transition|tissue homeostasis|positive regulation of protein phosphorylation|hair follicle development|morphogenesis of an epithelium|positive regulation of mesenchymal cell proliferation|chondrocyte differentiation|negative regulation of immune system process|heart valve development|heart valve morphogenesis|aortic valve morphogenesis|heart valve formation|endocardial cushion morphogenesis|chondrocyte differentiation involved in endochondral bone morphogenesis|chondrocyte hypertrophy|growth plate cartilage chondrocyte growth|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleosome assembly|chromatin remodeling|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|cytoskeleton organization|signal transduction|epidermal growth factor receptor signaling pathway|Notch signaling pathway|spermatogenesis|heart development|beta-catenin binding|positive regulation of cell population proliferation|male gonad development|regulation of cell cycle process|positive regulation of gene expression|positive regulation of epithelial cell migration|neural crest cell development|neural crest cell fate specification|positive regulation of phosphatidylinositol 3-kinase signaling|male germ-line sex determination|cAMP-mediated signaling|regulation of cell adhesion|extracellular matrix organization|negative regulation of ossification|negative regulation of bone mineralization|prostate gland development|negative regulation of epithelial cell differentiation|positive regulation of epithelial cell differentiation|mammary gland development|notochord development|otic vesicle formation|endocrine pancreas development|negative regulation of chondrocyte differentiation|positive regulation of chondrocyte differentiation|lacrimal gland development|protein-containing complex|protein kinase A catalytic subunit binding|protein localization to nucleus|somatic stem cell population maintenance|intrahepatic bile duct development|regulation of cell population proliferation|regulation of apoptotic process|negative regulation of apoptotic process|bHLH transcription factor binding|protein kinase B signaling|sequence-specific DNA binding|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of fatty acid oxidation|negative regulation of photoreceptor cell differentiation|oligodendrocyte differentiation|positive regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|cartilage development|Sertoli cell differentiation|Sertoli cell development|astrocyte fate commitment|retina development in camera-type eye|limb bud formation|retinal rod cell differentiation|epithelial tube branching involved in lung morphogenesis|lung epithelial cell differentiation|epithelial cell proliferation involved in prostatic bud elongation|bronchus cartilage development|trachea cartilage development|intestinal epithelial structure maintenance|regulation of cell proliferation involved in tissue homeostasis|positive regulation of cartilage development|regulation of branching involved in lung morphogenesis|morphogenesis of a branching epithelium|lung smooth muscle development|protein-containing complex assembly|negative regulation of biomineral tissue development|ERK1 and ERK2 cascade|Harderian gland development|response to fatty acid|cellular response to mechanical stimulus|cellular response to retinoic acid|cellular response to interleukin-1|cellular response to epidermal growth factor stimulus|cellular response to heparin|cellular response to transforming growth factor beta stimulus|cellular response to BMP stimulus|renal vesicle induction|ureter urothelium development|ureter smooth muscle cell differentiation|ureter morphogenesis|metanephric nephron tubule formation|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|positive regulation of kidney development|positive regulation of branching involved in ureteric bud morphogenesis|anterior head development|pre-mRNA intronic binding|cell-cell adhesion|positive regulation of extracellular matrix assembly|positive regulation of chondrocyte proliferation|negative regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of beta-catenin-TCF complex assembly|sequence-specific double-stranded DNA binding|positive regulation of male gonad development|positive regulation of cell proliferation involved in heart morphogenesis|positive regulation of mesenchymal stem cell differentiation|regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell apoptotic process" hsa04024 cAMP signaling pathway HMG SP1 4186.30093 3833.488693 4539.113167 1.18406849 0.243752533 0.445001822 1 25.14605343 31.05722066 6667 Sp1 transcription factor "GO:0000785,GO:0000791,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001103,GO:0001228,GO:0003677,GO:0003690,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0008022,GO:0008134,GO:0010628,GO:0016032,GO:0017053,GO:0032869,GO:0032993,GO:0033194,GO:0035035,GO:0042795,GO:0042803,GO:0042826,GO:0043425,GO:0043536,GO:0043565,GO:0043923,GO:0045540,GO:0045766,GO:0045893,GO:0045944,GO:0046872,GO:0048511,GO:0070491,GO:0071837,GO:1902004,GO:1904828,GO:1905564,GO:1990837" "chromatin|euchromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|double-stranded DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|protein C-terminus binding|transcription factor binding|positive regulation of gene expression|viral process|transcription repressor complex|cellular response to insulin stimulus|protein-DNA complex|response to hydroperoxide|histone acetyltransferase binding|snRNA transcription by RNA polymerase II|protein homodimerization activity|histone deacetylase binding|bHLH transcription factor binding|positive regulation of blood vessel endothelial cell migration|sequence-specific DNA binding|positive regulation by host of viral transcription|regulation of cholesterol biosynthetic process|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|rhythmic process|repressing transcription factor binding|HMG box domain binding|positive regulation of amyloid-beta formation|positive regulation of hydrogen sulfide biosynthetic process|positive regulation of vascular endothelial cell proliferation|sequence-specific double-stranded DNA binding" "hsa01522,hsa04137,hsa04350,hsa04915,hsa04927,hsa04928,hsa04934,hsa05016,hsa05017,hsa05163,hsa05200,hsa05202,hsa05224,hsa05231" "Endocrine resistance|Mitophagy - animal|TGF-beta signaling pathway|Estrogen signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Huntington disease|Spinocerebellar ataxia|Human cytomegalovirus infection|Pathways in cancer|Transcriptional misregulation in cancer|Breast cancer|Choline metabolism in cancer" zf-C2H2 SP100 736.8167095 696.2597943 777.3736247 1.116499374 0.158982443 0.672420128 1 4.638661184 5.40215531 6672 SP100 nuclear antigen "GO:0000122,GO:0000723,GO:0000781,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006978,GO:0010596,GO:0016032,GO:0016604,GO:0016605,GO:0019900,GO:0019904,GO:0030870,GO:0034340,GO:0034341,GO:0042802,GO:0043392,GO:0043433,GO:0045185,GO:0045765,GO:0045893,GO:0046826,GO:0046983,GO:0051271,GO:0060333,GO:0060337,GO:0070087,GO:1902041,GO:1902044" "negative regulation of transcription by RNA polymerase II|telomere maintenance|chromosome, telomeric region|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of endothelial cell migration|viral process|nuclear body|PML body|kinase binding|protein domain specific binding|Mre11 complex|response to type I interferon|response to interferon-gamma|identical protein binding|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|maintenance of protein location|regulation of angiogenesis|positive regulation of transcription, DNA-templated|negative regulation of protein export from nucleus|protein dimerization activity|negative regulation of cellular component movement|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|chromo shadow domain binding|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of Fas signaling pathway" "hsa05168,hsa05203" Herpes simplex virus 1 infection|Viral carcinogenesis SP110 110.9973856 111.6451565 110.3496147 0.988395897 -0.016839073 0.995204553 1 0.813002634 0.838182938 3431 SP110 nuclear body protein "GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0006357,GO:0016032,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|viral process|metal ion binding" SP140 8.075110419 13.19442759 2.95579325 0.224018301 -2.158311499 0.176784179 1 0.091416034 0.021361011 11262 SP140 nuclear body protein "GO:0000981,GO:0001650,GO:0003677,GO:0005515,GO:0005634,GO:0005739,GO:0006357,GO:0006952,GO:0016605,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|fibrillar center|DNA binding|protein binding|nucleus|mitochondrion|regulation of transcription by RNA polymerase II|defense response|PML body|metal ion binding" SP140L 227.844253 252.7240361 202.9644698 0.803107108 -0.316335686 0.543283877 1 2.185347597 1.830669408 93349 SP140 nuclear body protein like "GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0016604,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|nuclear body|metal ion binding" SP2 696.9486354 631.3026123 762.5946584 1.207970066 0.272584705 0.471755137 1 3.942933803 4.968114405 6668 Sp2 transcription factor "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0006955,GO:0035264,GO:0042826,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|immune response|multicellular organism growth|histone deacetylase binding|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 SP3 1511.804869 1577.241575 1446.368163 0.917023864 -0.124968817 0.707067369 1 6.638002459 6.34941884 6670 Sp3 transcription factor "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001227,GO:0001503,GO:0001779,GO:0001829,GO:0001889,GO:0001892,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0016605,GO:0017053,GO:0030183,GO:0030217,GO:0030219,GO:0030224,GO:0030324,GO:0030851,GO:0032993,GO:0043353,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0048596,GO:0048706,GO:0060136,GO:0060216,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|ossification|natural killer cell differentiation|trophectodermal cell differentiation|liver development|embryonic placenta development|chromatin binding|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|PML body|transcription repressor complex|B cell differentiation|T cell differentiation|megakaryocyte differentiation|monocyte differentiation|lung development|granulocyte differentiation|protein-DNA complex|enucleate erythrocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|embryonic camera-type eye morphogenesis|embryonic skeletal system development|embryonic process involved in female pregnancy|definitive hemopoiesis|sequence-specific double-stranded DNA binding" zf-C2H2 SP4 281.5951036 323.7709539 239.4192532 0.739471068 -0.435434391 0.367670888 1 1.409355962 1.087070759 6671 Sp4 transcription factor "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0042802,GO:0043565,GO:0046872" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|identical protein binding|sequence-specific DNA binding|metal ion binding" zf-C2H2 SP5 108.0564381 112.6601125 103.4527637 0.918273215 -0.12300463 0.86505303 1 1.803361965 1.727311849 389058 Sp5 transcription factor "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0036342,GO:0046872,GO:0060349,GO:0071407" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|post-anal tail morphogenesis|metal ion binding|bone morphogenesis|cellular response to organic cyclic compound" SP6 30.43655488 26.38885518 34.48425458 1.306773422 0.386009018 0.716116173 1 0.329837715 0.449589889 80320 Sp6 transcription factor "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005829,GO:0006357,GO:0042481,GO:0046872" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|cytosol|regulation of transcription by RNA polymerase II|regulation of odontogenesis|metal ion binding" SP9 49.48318586 48.71788648 50.24848524 1.031417594 0.04462856 0.984913089 1 0.96608813 1.039362901 100131390 Sp9 transcription factor "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0030326,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|embryonic limb morphogenesis|metal ion binding|sequence-specific double-stranded DNA binding" SPA17 108.590886 149.1985274 67.98324474 0.455656272 -1.133982169 0.087179582 1 5.69004448 2.704387647 53340 sperm autoantigenic protein 17 "GO:0003351,GO:0005515,GO:0005516,GO:0005576,GO:0005737,GO:0005929,GO:0007283,GO:0007338,GO:0007339,GO:0009897,GO:0031514,GO:0035686,GO:0097228" epithelial cilium movement involved in extracellular fluid movement|protein binding|calmodulin binding|extracellular region|cytoplasm|cilium|spermatogenesis|single fertilization|binding of sperm to zona pellucida|external side of plasma membrane|motile cilium|sperm fibrous sheath|sperm principal piece SPAAR 4.552456082 8.119647747 0.985264417 0.121343246 -3.042834281 0.175274214 1 0.256219012 0.032429697 158376 small regulatory polypeptide of amino acid response "GO:0031902,GO:0043416,GO:0046611,GO:0071230,GO:1904262,GO:1905103" late endosome membrane|regulation of skeletal muscle tissue regeneration|lysosomal proton-transporting V-type ATPase complex|cellular response to amino acid stimulus|negative regulation of TORC1 signaling|integral component of lysosomal membrane SPACA6 78.96416788 77.1366536 80.79168216 1.04738381 0.06679021 0.945655217 1 0.533993901 0.583388795 147650 sperm acrosome associated 6 "GO:0002080,GO:0005515,GO:0007342,GO:0016021" acrosomal membrane|protein binding|fusion of sperm to egg plasma membrane involved in single fertilization|integral component of membrane SPACA9 106.2640586 124.8395841 87.68853307 0.702409686 -0.509615356 0.446032205 1 2.321102984 1.700594739 11092 sperm acrosome associated 9 "GO:0001669,GO:0005515,GO:0005634,GO:0005881,GO:0036064,GO:0036126,GO:0048306,GO:0097546" acrosomal vesicle|protein binding|nucleus|cytoplasmic microtubule|ciliary basal body|sperm flagellum|calcium-dependent protein binding|ciliary base SPAG1 785.4833777 689.1551025 881.8116528 1.279554703 0.355641827 0.335079046 1 8.78069805 11.71935824 6674 sperm associated antigen 1 "GO:0005525,GO:0005737,GO:0005829,GO:0007338,GO:0016787,GO:0070286" GTP binding|cytoplasm|cytosol|single fertilization|hydrolase activity|axonemal dynein complex assembly SPAG16 209.144518 186.7518982 231.5371379 1.23981143 0.310120709 0.562842606 1 0.593072788 0.766972095 79582 sperm associated antigen 16 "GO:0005576,GO:0005930,GO:0007288,GO:0035082,GO:0036126,GO:0060271,GO:0090660,GO:0120197,GO:1990716" extracellular region|axoneme|sperm axoneme assembly|axoneme assembly|sperm flagellum|cilium assembly|cerebrospinal fluid circulation|mucociliary clearance|axonemal central apparatus SPAG4 314.3057838 471.9545253 156.6570422 0.331932493 -1.591038232 0.000825308 0.080956814 15.10924889 5.231287313 6676 sperm associated antigen 4 "GO:0005198,GO:0005515,GO:0005635,GO:0005637,GO:0005737,GO:0005856,GO:0006998,GO:0007283,GO:0016021,GO:0030154,GO:0031514,GO:0034993,GO:0043495" structural molecule activity|protein binding|nuclear envelope|nuclear inner membrane|cytoplasm|cytoskeleton|nuclear envelope organization|spermatogenesis|integral component of membrane|cell differentiation|motile cilium|meiotic nuclear membrane microtubule tethering complex|protein-membrane adaptor activity SPAG5 2311.665139 2070.510175 2552.820103 1.232942554 0.302105582 0.344896754 1 27.69784365 35.62088713 10615 sperm associated antigen 5 "GO:0000070,GO:0000776,GO:0000777,GO:0005515,GO:0005737,GO:0005829,GO:0007051,GO:0007059,GO:0008017,GO:0016604,GO:0030496,GO:0032388,GO:0034451,GO:0035371,GO:0051301,GO:0051988,GO:0071539,GO:0072686,GO:0090235,GO:0097431,GO:1905832" mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|protein binding|cytoplasm|cytosol|spindle organization|chromosome segregation|microtubule binding|nuclear body|midbody|positive regulation of intracellular transport|centriolar satellite|microtubule plus-end|cell division|regulation of attachment of spindle microtubules to kinetochore|protein localization to centrosome|mitotic spindle|regulation of metaphase plate congression|mitotic spindle pole|positive regulation of spindle assembly SPAG7 970.3647081 934.7744469 1005.954969 1.07614727 0.105875524 0.767090168 1 27.08411216 30.40200609 9552 sperm associated antigen 7 "GO:0003676,GO:0005515,GO:0005634" nucleic acid binding|protein binding|nucleus SPAG8 12.9420494 9.134603715 16.74949508 1.833631278 0.874703559 0.515481793 1 0.195534849 0.373983213 26206 sperm associated antigen 8 "GO:0001669,GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005819,GO:0007049,GO:0007283,GO:0007338,GO:0008017,GO:0008150,GO:0016020,GO:0030154,GO:0045944" acrosomal vesicle|molecular_function|protein binding|nucleus|cytoplasm|spindle|cell cycle|spermatogenesis|single fertilization|microtubule binding|biological_process|membrane|cell differentiation|positive regulation of transcription by RNA polymerase II SPAG9 3245.569621 3072.271716 3418.867525 1.112814178 0.154212706 0.628110027 1 17.74834312 20.60138395 9043 sperm associated antigen 9 "GO:0001669,GO:0001933,GO:0005078,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0007257,GO:0008432,GO:0016192,GO:0019894,GO:0030159,GO:0030335,GO:0032418,GO:0034451,GO:0042147,GO:0042802,GO:0045665,GO:0045666,GO:0048471,GO:0051146,GO:0051149,GO:0070062,GO:1903860" "acrosomal vesicle|negative regulation of protein phosphorylation|MAP-kinase scaffold activity|protein binding|cytoplasm|lysosomal membrane|cytosol|activation of JUN kinase activity|JUN kinase binding|vesicle-mediated transport|kinesin binding|signaling receptor complex adaptor activity|positive regulation of cell migration|lysosome localization|centriolar satellite|retrograde transport, endosome to Golgi|identical protein binding|negative regulation of neuron differentiation|positive regulation of neuron differentiation|perinuclear region of cytoplasm|striated muscle cell differentiation|positive regulation of muscle cell differentiation|extracellular exosome|negative regulation of dendrite extension" SPANXB1 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.220617765 0.335083672 728695 SPANX family member B1 "GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0007286" molecular_function|protein binding|nucleus|cytoplasm|spermatid development SPARC 5900.473231 8165.320766 3635.625697 0.445252036 -1.167305886 0.00037303 0.044894865 119.8332922 55.65437817 6678 secreted protein acidic and cysteine rich "GO:0001503,GO:0001937,GO:0002576,GO:0005201,GO:0005509,GO:0005515,GO:0005518,GO:0005576,GO:0005604,GO:0005615,GO:0005737,GO:0005739,GO:0005886,GO:0006898,GO:0007507,GO:0009629,GO:0009986,GO:0010288,GO:0010595,GO:0016363,GO:0016525,GO:0022604,GO:0030198,GO:0030324,GO:0031091,GO:0031092,GO:0031093,GO:0032496,GO:0033591,GO:0034097,GO:0042060,GO:0043231,GO:0043434,GO:0045471,GO:0046686,GO:0048839,GO:0048856,GO:0050807,GO:0050840,GO:0051384,GO:0051591,GO:0051592,GO:0062023,GO:0071682,GO:0098978" ossification|negative regulation of endothelial cell proliferation|platelet degranulation|extracellular matrix structural constituent|calcium ion binding|protein binding|collagen binding|extracellular region|basement membrane|extracellular space|cytoplasm|mitochondrion|plasma membrane|receptor-mediated endocytosis|heart development|response to gravity|cell surface|response to lead ion|positive regulation of endothelial cell migration|nuclear matrix|negative regulation of angiogenesis|regulation of cell morphogenesis|extracellular matrix organization|lung development|platelet alpha granule|platelet alpha granule membrane|platelet alpha granule lumen|response to lipopolysaccharide|response to L-ascorbic acid|response to cytokine|wound healing|intracellular membrane-bounded organelle|response to peptide hormone|response to ethanol|response to cadmium ion|inner ear development|anatomical structure development|regulation of synapse organization|extracellular matrix binding|response to glucocorticoid|response to cAMP|response to calcium ion|collagen-containing extracellular matrix|endocytic vesicle lumen|glutamatergic synapse SPART 1282.554227 1363.085866 1202.022588 0.881839229 -0.181412438 0.593011743 1 12.64386271 11.63014464 23111 spartin "GO:0005515,GO:0005737,GO:0005741,GO:0005811,GO:0005829,GO:0005886,GO:0009838,GO:0030496,GO:0030514,GO:0031625,GO:0034389,GO:0045202,GO:0048698,GO:0050905,GO:0051301,GO:0051881,GO:0060612" protein binding|cytoplasm|mitochondrial outer membrane|lipid droplet|cytosol|plasma membrane|abscission|midbody|negative regulation of BMP signaling pathway|ubiquitin protein ligase binding|lipid droplet organization|synapse|negative regulation of collateral sprouting in absence of injury|neuromuscular process|cell division|regulation of mitochondrial membrane potential|adipose tissue development hsa04144 Endocytosis SPAST 416.820542 441.5058462 392.1352378 0.888176773 -0.171081251 0.693145806 1 4.240605646 3.928648996 6683 spastin "GO:0000281,GO:0001578,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005783,GO:0005789,GO:0005811,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0006888,GO:0007409,GO:0008017,GO:0008089,GO:0008152,GO:0008568,GO:0010458,GO:0015630,GO:0016021,GO:0016853,GO:0016887,GO:0019896,GO:0030496,GO:0031117,GO:0031122,GO:0031410,GO:0031468,GO:0031965,GO:0032467,GO:0032506,GO:0034214,GO:0043014,GO:0044877,GO:0048471,GO:0048487,GO:0051013,GO:0051228,GO:0051260,GO:0061640,GO:0070062,GO:0090148,GO:1904115" mitotic cytokinesis|microtubule bundle formation|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|centrosome|spindle|cytosol|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|axonogenesis|microtubule binding|anterograde axonal transport|metabolic process|microtubule-severing ATPase activity|exit from mitosis|microtubule cytoskeleton|integral component of membrane|isomerase activity|ATPase activity|axonal transport of mitochondrion|midbody|positive regulation of microtubule depolymerization|cytoplasmic microtubule organization|cytoplasmic vesicle|nuclear envelope reassembly|nuclear membrane|positive regulation of cytokinesis|cytokinetic process|protein hexamerization|alpha-tubulin binding|protein-containing complex binding|perinuclear region of cytoplasm|beta-tubulin binding|microtubule severing|mitotic spindle disassembly|protein homooligomerization|cytoskeleton-dependent cytokinesis|extracellular exosome|membrane fission|axon cytoplasm SPATA1 3.463271234 1.014955968 5.911586499 5.824475823 2.542128219 0.321345721 1 0.018450804 0.112095471 100505741 spermatogenesis associated 1 SPATA13 316.5841145 358.2794568 274.8887722 0.767246815 -0.382237343 0.412178812 1 1.974492987 1.580180215 221178 spermatogenesis associated 13 "GO:0005085,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0016477,GO:0030027,GO:0030032,GO:0030175,GO:0030334,GO:0032587,GO:0046847,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|cytoplasm|cytosol|cell migration|lamellipodium|lamellipodium assembly|filopodium|regulation of cell migration|ruffle membrane|filopodium assembly|regulation of catalytic activity hsa04810 Regulation of actin cytoskeleton SPATA17 21.53948358 24.35894324 18.72002391 0.768507227 -0.379869269 0.757552861 1 0.204321719 0.16378662 128153 spermatogenesis associated 17 "GO:0005515,GO:0005516,GO:0005737" protein binding|calmodulin binding|cytoplasm SPATA18 68.51769267 36.53841486 100.4969705 2.750446916 1.459666059 0.06035689 1 0.418107052 1.199517781 132671 spermatogenesis associated 18 "GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0006974,GO:0035694,GO:0035695,GO:0042802,GO:0043231" protein binding|cytoplasm|mitochondrion|mitochondrial outer membrane|cellular response to DNA damage stimulus|mitochondrial protein catabolic process|mitophagy by induced vacuole formation|identical protein binding|intracellular membrane-bounded organelle SPATA2 597.0657849 605.9287131 588.2028567 0.970745971 -0.042834281 0.917148903 1 7.074262732 7.163127993 9825 spermatogenesis associated 2 "GO:0001650,GO:0005515,GO:0005654,GO:0005737,GO:0007283,GO:0010803,GO:0030159,GO:0044877,GO:0050727,GO:0060544,GO:0070266,GO:0070536,GO:0072520,GO:1990108,GO:1990381" fibrillar center|protein binding|nucleoplasm|cytoplasm|spermatogenesis|regulation of tumor necrosis factor-mediated signaling pathway|signaling receptor complex adaptor activity|protein-containing complex binding|regulation of inflammatory response|regulation of necroptotic process|necroptotic process|protein K63-linked deubiquitination|seminiferous tubule development|protein linear deubiquitination|ubiquitin-specific protease binding hsa04217 Necroptosis SPATA20 2591.945404 2775.904574 2407.986234 0.867460019 -0.205130829 0.520189126 1 52.28329262 47.307318 64847 spermatogenesis associated 20 "GO:0005576,GO:0005975,GO:0007275,GO:0007283,GO:0030154" extracellular region|carbohydrate metabolic process|multicellular organism development|spermatogenesis|cell differentiation SPATA21 5.04508829 8.119647747 1.970528833 0.242686493 -2.042834281 0.307402201 1 0.058806165 0.014886219 374955 spermatogenesis associated 21 GO:0005509 calcium ion binding SPATA24 48.46822989 46.68797455 50.24848524 1.076261837 0.106029105 0.926078968 1 0.983193848 1.103755862 202051 spermatogenesis associated 24 "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0007275,GO:0007283,GO:0030154" DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|multicellular organism development|spermatogenesis|cell differentiation SPATA25 24.62888881 33.49354696 15.76423066 0.470664713 -1.087228401 0.303319828 1 0.568094439 0.278899739 128497 spermatogenesis associated 25 "GO:0003674,GO:0005515,GO:0005575,GO:0007283,GO:0016021,GO:0030154" molecular_function|protein binding|cellular_component|spermatogenesis|integral component of membrane|cell differentiation SPATA2L 115.727991 131.9442759 99.51170607 0.754194946 -0.406990612 0.532952755 1 2.707662926 2.130071327 124044 spermatogenesis associated 2 like "GO:0005515,GO:0005737" protein binding|cytoplasm hsa04217 Necroptosis SPATA33 100.025865 102.5105528 97.54117724 0.951523278 -0.071689144 0.930959375 1 1.94522213 1.930654442 124045 spermatogenesis associated 33 "GO:0005515,GO:0005634,GO:0005737,GO:0005829" protein binding|nucleus|cytoplasm|cytosol SPATA4 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.180048824 0 132851 spermatogenesis associated 4 "GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0005930,GO:0008017,GO:0051493" molecular_function|protein binding|cellular_component|nucleus|axoneme|microtubule binding|regulation of cytoskeleton organization SPATA5 173.108138 181.6771183 164.5391576 0.905668028 -0.142945766 0.808556401 1 0.415165146 0.392198432 166378 spermatogenesis associated 5 "GO:0005524,GO:0005737,GO:0005739,GO:0005819,GO:0007283,GO:0007420,GO:0016887,GO:0030154" ATP binding|cytoplasm|mitochondrion|spindle|spermatogenesis|brain development|ATPase activity|cell differentiation hsa03008 Ribosome biogenesis in eukaryotes SPATA5L1 194.3628302 220.2454451 168.4802152 0.764965719 -0.386532999 0.479814032 1 4.151341577 3.312427426 79029 spermatogenesis associated 5 like 1 "GO:0005524,GO:0005737,GO:0005819,GO:0016887" ATP binding|cytoplasm|spindle|ATPase activity SPATA6 38.45228219 35.52345889 41.38110549 1.164895165 0.220200125 0.834691276 1 0.182597978 0.221870078 54558 spermatogenesis associated 6 "GO:0005576,GO:0007275,GO:0007283,GO:0030154,GO:0032027,GO:0044458,GO:0097224" extracellular region|multicellular organism development|spermatogenesis|cell differentiation|myosin light chain binding|motile cilium assembly|sperm connecting piece SPATA6L 15.91268842 10.14955968 21.67581716 2.135641135 1.094669242 0.370269595 1 0.09615402 0.214196147 55064 spermatogenesis associated 6 like "GO:0007283,GO:0032027,GO:0097224" spermatogenesis|myosin light chain binding|sperm connecting piece SPATA7 159.9015862 120.7797602 199.0234121 1.647820891 0.720559438 0.214866946 1 2.036985938 3.50117618 55812 spermatogenesis associated 7 "GO:0000226,GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0005930,GO:0007601,GO:0015630,GO:0032391,GO:0036064,GO:0045494,GO:0050896,GO:0120200,GO:0120206,GO:1903546,GO:1903621" microtubule cytoskeleton organization|protein binding|nucleoplasm|mitochondrion|cytosol|axoneme|visual perception|microtubule cytoskeleton|photoreceptor connecting cilium|ciliary basal body|photoreceptor cell maintenance|response to stimulus|rod photoreceptor outer segment|photoreceptor distal connecting cilium|protein localization to photoreceptor outer segment|protein localization to photoreceptor connecting cilium SPATA9 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.029929513 0.045458222 83890 spermatogenesis associated 9 "GO:0003674,GO:0005575,GO:0007275,GO:0007283,GO:0008150,GO:0016021,GO:0030154" molecular_function|cellular_component|multicellular organism development|spermatogenesis|biological_process|integral component of membrane|cell differentiation SPATC1L 554.853316 549.0911789 560.615453 1.020987906 0.029965777 0.944798203 1 8.612428347 9.171959941 84221 spermatogenesis and centriole associated 1 like "GO:0003674,GO:0005515,GO:0005575,GO:0005813,GO:0007283,GO:0008150,GO:0008154,GO:0010739,GO:0034237,GO:0097224,GO:2000481" molecular_function|protein binding|cellular_component|centrosome|spermatogenesis|biological_process|actin polymerization or depolymerization|positive regulation of protein kinase A signaling|protein kinase A regulatory subunit binding|sperm connecting piece|positive regulation of cAMP-dependent protein kinase activity SPATS2 1058.815819 919.5501073 1198.081531 1.302899669 0.381725992 0.274188505 1 13.55018009 18.41501049 65244 spermatogenesis associated serine rich 2 "GO:0003723,GO:0005737,GO:0005829" RNA binding|cytoplasm|cytosol SPATS2L 1466.702671 1625.959461 1307.445881 0.804107305 -0.314540058 0.344255298 1 20.70633912 17.36733813 26010 spermatogenesis associated serine rich 2 like "GO:0003723,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0032991" RNA binding|nucleoplasm|nucleolus|cytoplasm|cytosol|protein-containing complex SPC24 770.8258992 663.7812033 877.8705951 1.322530061 0.403300515 0.276092594 1 13.24071535 18.26555745 147841 SPC24 component of NDC80 kinetochore complex "GO:0000777,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0007049,GO:0031262,GO:0051301" condensed chromosome kinetochore|protein binding|nucleoplasm|nucleolus|cytosol|cell cycle|Ndc80 complex|cell division SPC25 432.9789277 367.4140606 498.5437948 1.356899064 0.440313406 0.299714594 1 10.98478513 15.54730215 57405 SPC25 component of NDC80 kinetochore complex "GO:0000777,GO:0005515,GO:0005634,GO:0005829,GO:0007052,GO:0007059,GO:0031262,GO:0051301" condensed chromosome kinetochore|protein binding|nucleus|cytosol|mitotic spindle organization|chromosome segregation|Ndc80 complex|cell division SPCS1 1675.424826 1682.796996 1668.052657 0.991238195 -0.012696315 0.971055857 1 22.51128665 23.27524582 28972 signal peptidase complex subunit 1 "GO:0003674,GO:0005515,GO:0005787,GO:0005789,GO:0006465,GO:0006508,GO:0008233,GO:0019068,GO:0019082,GO:0030176,GO:0043022,GO:0045047" molecular_function|protein binding|signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|proteolysis|peptidase activity|virion assembly|viral protein processing|integral component of endoplasmic reticulum membrane|ribosome binding|protein targeting to ER hsa03060 Protein export SPCS2 971.7805 964.20817 979.35283 1.015706837 0.022484057 0.952471719 1 18.14706142 19.22607422 9789 signal peptidase complex subunit 2 "GO:0005787,GO:0005789,GO:0006465,GO:0008233,GO:0016021,GO:0045047" signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|peptidase activity|integral component of membrane|protein targeting to ER hsa03060 Protein export SPCS3 2168.047386 1985.253874 2350.840898 1.184151271 0.243853391 0.447194018 1 22.00615127 27.18111132 60559 signal peptidase complex subunit 3 "GO:0005515,GO:0005783,GO:0005787,GO:0005789,GO:0006465,GO:0006508,GO:0008233,GO:0016021,GO:0019082,GO:0045047" protein binding|endoplasmic reticulum|signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|proteolysis|peptidase activity|integral component of membrane|viral protein processing|protein targeting to ER hsa03060 Protein export SPDL1 741.7294235 863.7275291 619.731318 0.717507891 -0.478933396 0.19939284 1 14.5815841 10.91307949 54908 spindle apparatus coiled-coil protein 1 "GO:0000132,GO:0000922,GO:0000940,GO:0005515,GO:0005634,GO:0005815,GO:0005829,GO:0007080,GO:0007094,GO:0016477,GO:0019899,GO:0034501,GO:0043515,GO:0051301" establishment of mitotic spindle orientation|spindle pole|condensed chromosome outer kinetochore|protein binding|nucleus|microtubule organizing center|cytosol|mitotic metaphase plate congression|mitotic spindle assembly checkpoint|cell migration|enzyme binding|protein localization to kinetochore|kinetochore binding|cell division SPDYE18 6.522984915 8.119647747 4.926322083 0.606716232 -0.720906186 0.726457076 1 0.331104279 0.209539709 100505767 speedy/RINGO cell cycle regulator family member E18 "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation SPECC1 1778.623974 1497.060053 2060.187895 1.376155813 0.460643826 0.157158395 1 8.632677945 12.39164828 92521 sperm antigen with calponin homology and coiled-coil domains 1 "GO:0001650,GO:0005654,GO:0005815,GO:0005829,GO:0016020,GO:0030036,GO:0031941,GO:0043231" fibrillar center|nucleoplasm|microtubule organizing center|cytosol|membrane|actin cytoskeleton organization|filamentous actin|intracellular membrane-bounded organelle SPECC1L 2392.401398 2201.439495 2583.3633 1.173488213 0.230803351 0.470140657 1 15.57629844 19.0659707 23384 sperm antigen with calponin homology and coiled-coil domains 1 like "GO:0005515,GO:0005737,GO:0005815,GO:0005819,GO:0005921,GO:0007049,GO:0007155,GO:0015629,GO:0030036,GO:0031941,GO:0051301" protein binding|cytoplasm|microtubule organizing center|spindle|gap junction|cell cycle|cell adhesion|actin cytoskeleton|actin cytoskeleton organization|filamentous actin|cell division SPEF1 12.95689517 10.14955968 15.76423066 1.553193553 0.635237624 0.652496694 1 0.325341388 0.527085202 25876 sperm flagellar 1 "GO:0001578,GO:0003341,GO:0003674,GO:0003779,GO:0005515,GO:0005737,GO:0005874,GO:0005902,GO:0005930,GO:0007026,GO:0008017,GO:0016323,GO:0016324,GO:0016477,GO:0030027,GO:0030032,GO:0030175,GO:0046847,GO:0051493,GO:0060548,GO:0097542,GO:0097729,GO:1904158,GO:1990716,GO:2000095" "microtubule bundle formation|cilium movement|molecular_function|actin binding|protein binding|cytoplasm|microtubule|microvillus|axoneme|negative regulation of microtubule depolymerization|microtubule binding|basolateral plasma membrane|apical plasma membrane|cell migration|lamellipodium|lamellipodium assembly|filopodium|filopodium assembly|regulation of cytoskeleton organization|negative regulation of cell death|ciliary tip|9+2 motile cilium|axonemal central apparatus assembly|axonemal central apparatus|regulation of Wnt signaling pathway, planar cell polarity pathway" SPEF2 91.8913715 85.25630134 98.52644165 1.155649965 0.208704486 0.77637413 1 0.47465438 0.572162952 79925 sperm flagellar 2 "GO:0002177,GO:0003351,GO:0003674,GO:0005576,GO:0005737,GO:0005794,GO:0007283,GO:0007288,GO:0036126,GO:0048705,GO:0048854,GO:0060541,GO:0097225" manchette|epithelial cilium movement involved in extracellular fluid movement|molecular_function|extracellular region|cytoplasm|Golgi apparatus|spermatogenesis|sperm axoneme assembly|sperm flagellum|skeletal system morphogenesis|brain morphogenesis|respiratory system development|sperm midpiece SPEG 632.7028129 381.6234441 883.7821816 2.315848765 1.211541042 0.001927079 0.137471737 1.14474539 2.765253989 10290 striated muscle enriched protein kinase "GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0006468,GO:0007517,GO:0008285,GO:0042692,GO:0106310,GO:0106311" protein kinase activity|protein binding|ATP binding|nucleus|protein phosphorylation|muscle organ development|negative regulation of cell population proliferation|muscle cell differentiation|protein serine kinase activity|protein threonine kinase activity SPEN 2807.044562 3167.677577 2446.411546 0.772304468 -0.372758377 0.241867475 1 12.95370968 10.43514857 23013 spen family transcriptional repressor "GO:0000122,GO:0000398,GO:0001085,GO:0003676,GO:0003677,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0007219,GO:0016032,GO:0017053,GO:0045892,GO:0050769,GO:0070062" "negative regulation of transcription by RNA polymerase II|mRNA splicing, via spliceosome|RNA polymerase II transcription factor binding|nucleic acid binding|DNA binding|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|Notch signaling pathway|viral process|transcription repressor complex|negative regulation of transcription, DNA-templated|positive regulation of neurogenesis|extracellular exosome" SPG11 904.4964906 809.9348628 999.0581184 1.233504278 0.30276272 0.39915368 1 4.891526773 6.293627355 80208 "SPG11 vesicle trafficking associated, spatacsin" "GO:0005515,GO:0005730,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0007268,GO:0008088,GO:0030424,GO:0030425,GO:0031410,GO:0045202,GO:0048489,GO:0048675,GO:0090389,GO:0090659" protein binding|nucleolus|cytoplasm|lysosomal membrane|cytosol|plasma membrane|chemical synaptic transmission|axo-dendritic transport|axon|dendrite|cytoplasmic vesicle|synapse|synaptic vesicle transport|axon extension|phagosome-lysosome fusion involved in apoptotic cell clearance|walking behavior "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases SPG21 910.6968278 930.714623 890.6790326 0.956984032 -0.063433242 0.862221497 1 18.34854507 18.31564655 51324 "SPG21 abhydrolase domain containing, maspardin" "GO:0005515,GO:0005794,GO:0005829,GO:0010008,GO:0030140,GO:0042609,GO:0043231,GO:0050851" protein binding|Golgi apparatus|cytosol|endosome membrane|trans-Golgi network transport vesicle|CD4 receptor binding|intracellular membrane-bounded organelle|antigen receptor-mediated signaling pathway hsa04144 Endocytosis SPG7 1434.926037 1373.235425 1496.616649 1.089847102 0.124125749 0.710885402 1 11.692927 13.29244102 6687 "SPG7 matrix AAA peptidase subunit, paraplegin" "GO:0004176,GO:0004222,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005757,GO:0006508,GO:0006851,GO:0007399,GO:0008053,GO:0008233,GO:0008270,GO:0034982,GO:0042407,GO:0046902,GO:0051082,GO:0065003,GO:1902686" ATP-dependent peptidase activity|metalloendopeptidase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial permeability transition pore complex|proteolysis|mitochondrial calcium ion transmembrane transport|nervous system development|mitochondrial fusion|peptidase activity|zinc ion binding|mitochondrial protein processing|cristae formation|regulation of mitochondrial membrane permeability|unfolded protein binding|protein-containing complex assembly|mitochondrial outer membrane permeabilization involved in programmed cell death SPHK1 1042.016343 983.4923334 1100.540353 1.119012641 0.162226334 0.644223998 1 21.1329729 24.6667265 8877 sphingosine kinase 1 "GO:0000287,GO:0001568,GO:0001727,GO:0003376,GO:0003677,GO:0003951,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005905,GO:0006457,GO:0006473,GO:0006665,GO:0006670,GO:0006954,GO:0007420,GO:0008289,GO:0008481,GO:0010800,GO:0010803,GO:0016020,GO:0016310,GO:0016407,GO:0017050,GO:0019722,GO:0030100,GO:0030139,GO:0030148,GO:0030307,GO:0030335,GO:0031398,GO:0031901,GO:0032651,GO:0032740,GO:0034612,GO:0035556,GO:0035924,GO:0038036,GO:0043066,GO:0043231,GO:0045766,GO:0045840,GO:0045931,GO:0045987,GO:0046512,GO:0046521,GO:0046834,GO:0048146,GO:0050764,GO:0051092,GO:0051721,GO:0070301,GO:0071363,GO:0071897,GO:0098793,GO:0150077,GO:1900060,GO:1900745,GO:1901224,GO:1903978,GO:1905364" magnesium ion binding|blood vessel development|lipid kinase activity|sphingosine-1-phosphate receptor signaling pathway|DNA binding|NAD+ kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|clathrin-coated pit|protein folding|protein acetylation|sphingolipid metabolic process|sphingosine metabolic process|inflammatory response|brain development|lipid binding|sphinganine kinase activity|positive regulation of peptidyl-threonine phosphorylation|regulation of tumor necrosis factor-mediated signaling pathway|membrane|phosphorylation|acetyltransferase activity|D-erythro-sphingosine kinase activity|calcium-mediated signaling|regulation of endocytosis|endocytic vesicle|sphingolipid biosynthetic process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of protein ubiquitination|early endosome membrane|regulation of interleukin-1 beta production|positive regulation of interleukin-17 production|response to tumor necrosis factor|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|sphingosine-1-phosphate receptor activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of angiogenesis|positive regulation of mitotic nuclear division|positive regulation of mitotic cell cycle|positive regulation of smooth muscle contraction|sphingosine biosynthetic process|sphingoid catabolic process|lipid phosphorylation|positive regulation of fibroblast proliferation|regulation of phagocytosis|positive regulation of NF-kappaB transcription factor activity|protein phosphatase 2A binding|cellular response to hydrogen peroxide|cellular response to growth factor stimulus|DNA biosynthetic process|presynapse|regulation of neuroinflammatory response|negative regulation of ceramide biosynthetic process|positive regulation of p38MAPK cascade|positive regulation of NIK/NF-kappaB signaling|regulation of microglial cell activation|regulation of endosomal vesicle fusion "hsa00600,hsa04020,hsa04071,hsa04072,hsa04370,hsa04371,hsa04666,hsa05152" Sphingolipid metabolism|Calcium signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|VEGF signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Tuberculosis SPHK2 279.4909627 314.6363502 244.3455753 0.776596776 -0.364762376 0.452303472 1 3.858407062 3.125500387 56848 sphingosine kinase 2 "GO:0000786,GO:0001727,GO:0002367,GO:0003376,GO:0003951,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005765,GO:0005783,GO:0005829,GO:0006665,GO:0006669,GO:0006670,GO:0008481,GO:0016020,GO:0016310,GO:0017050,GO:0030148,GO:0030308,GO:0031064,GO:0031267,GO:0031493,GO:0032616,GO:0032635,GO:0032640,GO:0033008,GO:0038036,GO:0043065,GO:0043122,GO:0043231,GO:0043306,GO:0043977,GO:0043980,GO:0045815,GO:0046512,GO:0046834,GO:0090037,GO:0090280,GO:1901726,GO:1903426,GO:1904628,GO:1904959,GO:2000304,GO:2000617,GO:2001169" "nucleosome|lipid kinase activity|cytokine production involved in immune response|sphingosine-1-phosphate receptor signaling pathway|NAD+ kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|lysosomal membrane|endoplasmic reticulum|cytosol|sphingolipid metabolic process|sphinganine-1-phosphate biosynthetic process|sphingosine metabolic process|sphinganine kinase activity|membrane|phosphorylation|D-erythro-sphingosine kinase activity|sphingolipid biosynthetic process|negative regulation of cell growth|negative regulation of histone deacetylation|small GTPase binding|nucleosomal histone binding|interleukin-13 production|interleukin-6 production|tumor necrosis factor production|positive regulation of mast cell activation involved in immune response|sphingosine-1-phosphate receptor activity|positive regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|positive regulation of mast cell degranulation|histone H2A-K5 acetylation|histone H2B-K12 acetylation|positive regulation of gene expression, epigenetic|sphingosine biosynthetic process|lipid phosphorylation|positive regulation of protein kinase C signaling|positive regulation of calcium ion import|negative regulation of histone deacetylase activity|regulation of reactive oxygen species biosynthetic process|cellular response to phorbol 13-acetate 12-myristate|regulation of cytochrome-c oxidase activity|positive regulation of ceramide biosynthetic process|positive regulation of histone H3-K9 acetylation|regulation of ATP biosynthetic process" "hsa00600,hsa04020,hsa04071,hsa04072,hsa04370,hsa04371,hsa04666,hsa05152" Sphingolipid metabolism|Calcium signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|VEGF signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Tuberculosis SPI1 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.149671774 0.067356407 6688 Spi-1 proto-oncogene "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001227,GO:0001228,GO:0002320,GO:0003700,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0008134,GO:0010629,GO:0030098,GO:0030154,GO:0030218,GO:0030225,GO:0030851,GO:0035019,GO:0043011,GO:0043966,GO:0044027,GO:0045347,GO:0045646,GO:0045814,GO:0045892,GO:0045893,GO:0045944,GO:0051525,GO:0060033,GO:0070102,GO:0071361,GO:0090241,GO:0090402,GO:1900745,GO:1902262,GO:1902895" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|lymphoid progenitor cell differentiation|DNA-binding transcription factor activity|RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription factor binding|negative regulation of gene expression|lymphocyte differentiation|cell differentiation|erythrocyte differentiation|macrophage differentiation|granulocyte differentiation|somatic stem cell population maintenance|myeloid dendritic cell differentiation|histone H3 acetylation|hypermethylation of CpG island|negative regulation of MHC class II biosynthetic process|regulation of erythrocyte differentiation|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|NFAT protein binding|anatomical structure regression|interleukin-6-mediated signaling pathway|cellular response to ethanol|negative regulation of histone H4 acetylation|oncogene-induced cell senescence|positive regulation of p38MAPK cascade|apoptotic process involved in blood vessel morphogenesis|positive regulation of pri-miRNA transcription by RNA polymerase II" "hsa04380,hsa05166,hsa05200,hsa05202,hsa05221" Osteoclast differentiation|Human T-cell leukemia virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia ETS SPICE1 431.8694538 426.2815067 437.4574009 1.026217169 0.037336067 0.935590906 1 3.817124202 4.085935411 152185 spindle and centriole associated protein 1 "GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0046599,GO:0051301,GO:0051310,GO:0090307" protein binding|cytoplasm|centrosome|centriole|spindle|regulation of centriole replication|cell division|metaphase plate congression|mitotic spindle assembly SPIDR 1320.862257 1152.98998 1488.734533 1.291194684 0.368706544 0.274362683 1 13.52985982 18.22220618 23514 scaffold protein involved in DNA repair "GO:0000228,GO:0000724,GO:0005515,GO:0005654,GO:0006974,GO:0010569,GO:0031334,GO:0070202,GO:0071479,GO:0072711,GO:0072757,GO:2000781" nuclear chromosome|double-strand break repair via homologous recombination|protein binding|nucleoplasm|cellular response to DNA damage stimulus|regulation of double-strand break repair via homologous recombination|positive regulation of protein-containing complex assembly|regulation of establishment of protein localization to chromosome|cellular response to ionizing radiation|cellular response to hydroxyurea|cellular response to camptothecin|positive regulation of double-strand break repair SPIN1 2391.71973 2323.234212 2460.205248 1.05895705 0.082644077 0.796770746 1 26.38789346 29.14734476 10927 spindlin 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006325,GO:0006355,GO:0007275,GO:0007276,GO:0009303,GO:0016055,GO:0030177,GO:0031965,GO:0035064,GO:0045893,GO:0051321" "protein binding|nucleus|nucleoplasm|nucleolus|cytosol|chromatin organization|regulation of transcription, DNA-templated|multicellular organism development|gamete generation|rRNA transcription|Wnt signaling pathway|positive regulation of Wnt signaling pathway|nuclear membrane|methylated histone binding|positive regulation of transcription, DNA-templated|meiotic cell cycle" SPIN2A 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.031050401 0.047160674 54466 spindlin family member 2A "GO:0005515,GO:0005654,GO:0005829,GO:0006355,GO:0007049,GO:0007276,GO:0035064,GO:0051726" "protein binding|nucleoplasm|cytosol|regulation of transcription, DNA-templated|cell cycle|gamete generation|methylated histone binding|regulation of cell cycle" SPIN2B 110.9825398 110.6302006 111.3348791 1.006369676 0.009160356 1 1 4.135077032 4.340673062 474343 spindlin family member 2B "GO:0005515,GO:0005654,GO:0005829,GO:0006355,GO:0006915,GO:0007049,GO:0007276,GO:0035064,GO:0051726" "protein binding|nucleoplasm|cytosol|regulation of transcription, DNA-templated|apoptotic process|cell cycle|gamete generation|methylated histone binding|regulation of cell cycle" SPIN3 305.6328829 283.1727152 328.0930507 1.158632287 0.212422774 0.655107396 1 2.949752993 3.56489881 169981 spindlin family member 3 "GO:0005515,GO:0005654,GO:0005829,GO:0006355,GO:0007276,GO:0035064" "protein binding|nucleoplasm|cytosol|regulation of transcription, DNA-templated|gamete generation|methylated histone binding" SPIN4 502.8678749 430.3413306 575.3944193 1.337065205 0.419069823 0.304755563 1 5.309444639 7.404872985 139886 spindlin family member 4 "GO:0005515,GO:0005654,GO:0005829,GO:0006355,GO:0007276,GO:0035064" "protein binding|nucleoplasm|cytosol|regulation of transcription, DNA-templated|gamete generation|methylated histone binding" SPINDOC 1480.263046 1374.250381 1586.275711 1.154284352 0.206998668 0.533613576 1 25.04531621 30.15471701 144097 spindlin interactor and repressor of chromatin binding "GO:0005515,GO:0045892" "protein binding|negative regulation of transcription, DNA-templated" SPINT1 1163.534433 1140.810508 1186.258358 1.03983821 0.056359075 0.872012768 1 19.31729446 20.9521214 6692 "serine peptidase inhibitor, Kunitz type 1" "GO:0001843,GO:0004867,GO:0005576,GO:0005615,GO:0005886,GO:0010951,GO:0016020,GO:0030198,GO:0045687,GO:0060670,GO:0060674,GO:0070062,GO:0071773,GO:2000178" neural tube closure|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|plasma membrane|negative regulation of endopeptidase activity|membrane|extracellular matrix organization|positive regulation of glial cell differentiation|branching involved in labyrinthine layer morphogenesis|placenta blood vessel development|extracellular exosome|cellular response to BMP stimulus|negative regulation of neural precursor cell proliferation "hsa05202,hsa05215" Transcriptional misregulation in cancer|Prostate cancer SPINT2 499.9890322 401.9225635 598.0555008 1.487986879 0.573361805 0.160858421 1 12.05921798 18.71691106 10653 "serine peptidase inhibitor, Kunitz type 2" "GO:0001843,GO:0004866,GO:0004867,GO:0005576,GO:0005737,GO:0005886,GO:0007163,GO:0010951,GO:0016021,GO:0022408,GO:0060672,GO:0071711,GO:0071773,GO:2000146,GO:2000178" neural tube closure|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|cytoplasm|plasma membrane|establishment or maintenance of cell polarity|negative regulation of endopeptidase activity|integral component of membrane|negative regulation of cell-cell adhesion|epithelial cell morphogenesis involved in placental branching|basement membrane organization|cellular response to BMP stimulus|negative regulation of cell motility|negative regulation of neural precursor cell proliferation SPIRE1 1579.059433 1359.026042 1799.092825 1.323810412 0.404696523 0.219531577 1 10.24406529 14.1453618 56907 spire type actin nucleation factor 1 "GO:0003779,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0005938,GO:0015031,GO:0016192,GO:0030036,GO:0030041,GO:0030659,GO:0031307,GO:0032154,GO:0036089,GO:0040038,GO:0045010,GO:0046907,GO:0048193,GO:0048471,GO:0051295,GO:0051639,GO:0070649,GO:0090141,GO:2000781" actin binding|protein binding|nucleoplasm|cytosol|cytoskeleton|cell cortex|protein transport|vesicle-mediated transport|actin cytoskeleton organization|actin filament polymerization|cytoplasmic vesicle membrane|integral component of mitochondrial outer membrane|cleavage furrow|cleavage furrow formation|polar body extrusion after meiotic divisions|actin nucleation|intracellular transport|Golgi vesicle transport|perinuclear region of cytoplasm|establishment of meiotic spindle localization|actin filament network formation|formin-nucleated actin cable assembly|positive regulation of mitochondrial fission|positive regulation of double-strand break repair SPIRE2 236.4889461 237.4996966 235.4781956 0.991488406 -0.012332193 0.990121468 1 3.68069822 3.806569653 84501 spire type actin nucleation factor 2 "GO:0003779,GO:0005829,GO:0005856,GO:0005938,GO:0015031,GO:0016192,GO:0030036,GO:0030041,GO:0030659,GO:0032154,GO:0036089,GO:0040038,GO:0045010,GO:0046907,GO:0048193,GO:0051295,GO:0051639,GO:0070649,GO:2000781" actin binding|cytosol|cytoskeleton|cell cortex|protein transport|vesicle-mediated transport|actin cytoskeleton organization|actin filament polymerization|cytoplasmic vesicle membrane|cleavage furrow|cleavage furrow formation|polar body extrusion after meiotic divisions|actin nucleation|intracellular transport|Golgi vesicle transport|establishment of meiotic spindle localization|actin filament network formation|formin-nucleated actin cable assembly|positive regulation of double-strand break repair SPNS1 814.8104587 774.4114039 855.2095136 1.104334866 0.143177704 0.69763589 1 12.41177394 14.29718611 83985 sphingolipid transporter 1 (putative) "GO:0005515,GO:0005743,GO:0005765,GO:0006869,GO:0016021,GO:0022857,GO:0055085" protein binding|mitochondrial inner membrane|lysosomal membrane|lipid transport|integral component of membrane|transmembrane transporter activity|transmembrane transport SPNS2 21.13592602 30.44867905 11.823173 0.388298388 -1.364762376 0.217509046 1 0.439099709 0.177846231 124976 sphingolipid transporter 2 "GO:0001782,GO:0002920,GO:0003376,GO:0005886,GO:0006665,GO:0006869,GO:0010008,GO:0016021,GO:0022857,GO:0043029,GO:0046624,GO:0048073,GO:0048535,GO:0055085,GO:0060348,GO:0072676" B cell homeostasis|regulation of humoral immune response|sphingosine-1-phosphate receptor signaling pathway|plasma membrane|sphingolipid metabolic process|lipid transport|endosome membrane|integral component of membrane|transmembrane transporter activity|T cell homeostasis|sphingolipid transporter activity|regulation of eye pigmentation|lymph node development|transmembrane transport|bone development|lymphocyte migration SPNS3 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.056575721 201305 sphingolipid transporter 3 (putative) "GO:0006869,GO:0016021,GO:0022857,GO:0055085" lipid transport|integral component of membrane|transmembrane transporter activity|transmembrane transport SPOCD1 106.9699749 72.06187375 141.878076 1.968836898 0.977343601 0.141722447 1 0.87986492 1.806931431 90853 SPOC domain containing 1 "GO:0005634,GO:0006306,GO:0006351,GO:0007283,GO:0010529,GO:0010923" "nucleus|DNA methylation|transcription, DNA-templated|spermatogenesis|negative regulation of transposition|negative regulation of phosphatase activity" SPOCK1 14.59809533 21.31407534 7.882115332 0.369807989 -1.435151704 0.250679294 1 0.223773367 0.08631785 6695 "SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1" "GO:0001558,GO:0001764,GO:0004867,GO:0004869,GO:0005509,GO:0005515,GO:0005615,GO:0005737,GO:0007155,GO:0007399,GO:0008191,GO:0010812,GO:0010951,GO:0010977,GO:0014069,GO:0016528,GO:0021953,GO:0022008,GO:0031594,GO:0033268" regulation of cell growth|neuron migration|serine-type endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|calcium ion binding|protein binding|extracellular space|cytoplasm|cell adhesion|nervous system development|metalloendopeptidase inhibitor activity|negative regulation of cell-substrate adhesion|negative regulation of endopeptidase activity|negative regulation of neuron projection development|postsynaptic density|sarcoplasm|central nervous system neuron differentiation|neurogenesis|neuromuscular junction|node of Ranvier SPOCK2 55.21390145 70.03196182 40.39584108 0.576820069 -0.793806733 0.33688184 1 0.45955841 0.276501194 9806 "SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2" "GO:0005509,GO:0005515,GO:0005539,GO:0007416,GO:0008191,GO:0010811,GO:0010951,GO:0019800,GO:0030198,GO:0031012,GO:0045595,GO:0050840,GO:1990830,GO:2000147" calcium ion binding|protein binding|glycosaminoglycan binding|synapse assembly|metalloendopeptidase inhibitor activity|positive regulation of cell-substrate adhesion|negative regulation of endopeptidase activity|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix organization|extracellular matrix|regulation of cell differentiation|extracellular matrix binding|cellular response to leukemia inhibitory factor|positive regulation of cell motility SPOCK3 54.36497062 45.67301858 63.05692266 1.380616491 0.465312622 0.582637487 1 0.647586021 0.932580761 50859 "SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3" "GO:0005509,GO:0005539,GO:0005576,GO:0008191,GO:0010951,GO:0019800,GO:2000146" calcium ion binding|glycosaminoglycan binding|extracellular region|metalloendopeptidase inhibitor activity|negative regulation of endopeptidase activity|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|negative regulation of cell motility SPON2 34.27369211 19.2841634 49.26322083 2.554594659 1.353094395 0.15811081 1 0.478059151 1.273853737 10417 spondin 2 "GO:0005515,GO:0007155,GO:0031012,GO:0045087,GO:0046872,GO:0070062" protein binding|cell adhesion|extracellular matrix|innate immune response|metal ion binding|extracellular exosome SPOP 1087.604247 1203.737778 971.4707147 0.807045132 -0.309278739 0.37362482 1 17.10580021 14.39982279 8405 speckle type BTB/POZ protein "GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016607,GO:0030162,GO:0031463,GO:0031625,GO:0043161" protein polyubiquitination|protein binding|nucleus|nucleoplasm|cytoplasm|nuclear speck|regulation of proteolysis|Cul3-RING ubiquitin ligase complex|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process hsa04340 Hedgehog signaling pathway SPOPL 394.8559741 320.726086 468.9858623 1.462262918 0.548202734 0.208157115 1 2.780969834 4.241677782 339745 speckle type BTB/POZ protein like "GO:0005515,GO:0005634,GO:0005737,GO:0016567,GO:0030162,GO:0031397,GO:0031463,GO:0031625,GO:0043161" protein binding|nucleus|cytoplasm|protein ubiquitination|regulation of proteolysis|negative regulation of protein ubiquitination|Cul3-RING ubiquitin ligase complex|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process hsa04340 Hedgehog signaling pathway SPOUT1 888.397488 888.0864723 888.7085037 1.000700418 0.001010135 1 1 10.35892373 10.81271227 51490 SPOUT domain containing methyltransferase 1 "GO:0000776,GO:0000777,GO:0003723,GO:0005515,GO:0005737,GO:0007049,GO:0008168,GO:0010608,GO:0031616,GO:0032259,GO:0035196,GO:0035198,GO:0051301,GO:0051661,GO:0072686" kinetochore|condensed chromosome kinetochore|RNA binding|protein binding|cytoplasm|cell cycle|methyltransferase activity|posttranscriptional regulation of gene expression|spindle pole centrosome|methylation|production of miRNAs involved in gene silencing by miRNA|miRNA binding|cell division|maintenance of centrosome location|mitotic spindle SPP1 9.56785282 14.20938356 4.926322083 0.346694989 -1.528261108 0.297156206 1 0.411231514 0.148713325 6696 secreted phosphoprotein 1 "GO:0001649,GO:0005125,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0006710,GO:0006954,GO:0007155,GO:0007165,GO:0007566,GO:0030198,GO:0031214,GO:0033280,GO:0042995,GO:0043687,GO:0044267,GO:0045780,GO:0045893,GO:0046697,GO:0048471,GO:0048545,GO:0048685,GO:0050840,GO:0070062,GO:0071394,GO:2000866" "osteoblast differentiation|cytokine activity|integrin binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|androgen catabolic process|inflammatory response|cell adhesion|signal transduction|embryo implantation|extracellular matrix organization|biomineral tissue development|response to vitamin D|cell projection|post-translational protein modification|cellular protein metabolic process|positive regulation of bone resorption|positive regulation of transcription, DNA-templated|decidualization|perinuclear region of cytoplasm|response to steroid hormone|negative regulation of collateral sprouting of intact axon in response to injury|extracellular matrix binding|extracellular exosome|cellular response to testosterone stimulus|positive regulation of estradiol secretion" "hsa04151,hsa04371,hsa04510,hsa04512,hsa04620,hsa04929,hsa05165" PI3K-Akt signaling pathway|Apelin signaling pathway|Focal adhesion|ECM-receptor interaction|Toll-like receptor signaling pathway|GnRH secretion|Human papillomavirus infection SPPL2A 950.2194897 837.3386739 1063.100305 1.269618063 0.344394559 0.332994391 1 5.785572971 7.66188092 84888 signal peptide peptidase like 2A "GO:0005515,GO:0005765,GO:0005770,GO:0005886,GO:0006509,GO:0010803,GO:0016020,GO:0030660,GO:0031293,GO:0031902,GO:0033619,GO:0042500,GO:0042803,GO:0043231,GO:0050776,GO:0070062,GO:0071458,GO:0071556" "protein binding|lysosomal membrane|late endosome|plasma membrane|membrane protein ectodomain proteolysis|regulation of tumor necrosis factor-mediated signaling pathway|membrane|Golgi-associated vesicle membrane|membrane protein intracellular domain proteolysis|late endosome membrane|membrane protein proteolysis|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|intracellular membrane-bounded organelle|regulation of immune response|extracellular exosome|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane" SPPL2B 532.328568 524.7322356 539.9249003 1.028953176 0.041177331 0.923221965 1 4.854034081 5.209719765 56928 signal peptide peptidase like 2B "GO:0000139,GO:0005515,GO:0005654,GO:0005765,GO:0005813,GO:0005886,GO:0006509,GO:0010008,GO:0010803,GO:0015629,GO:0016020,GO:0030660,GO:0031293,GO:0033619,GO:0042500,GO:0042803,GO:0050776,GO:0071458,GO:0071556" "Golgi membrane|protein binding|nucleoplasm|lysosomal membrane|centrosome|plasma membrane|membrane protein ectodomain proteolysis|endosome membrane|regulation of tumor necrosis factor-mediated signaling pathway|actin cytoskeleton|membrane|Golgi-associated vesicle membrane|membrane protein intracellular domain proteolysis|membrane protein proteolysis|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|regulation of immune response|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane" SPPL3 1293.946872 1333.652142 1254.241602 0.940456332 -0.088567138 0.795128181 1 16.18614334 15.87807858 121665 signal peptide peptidase like 3 "GO:0005515,GO:0005791,GO:0005794,GO:0005886,GO:0006465,GO:0006509,GO:0007204,GO:0016020,GO:0030660,GO:0032092,GO:0033116,GO:0033619,GO:0035307,GO:0042500,GO:0042803,GO:0043231,GO:0050852,GO:0070886,GO:0071458,GO:0071556" "protein binding|rough endoplasmic reticulum|Golgi apparatus|plasma membrane|signal peptide processing|membrane protein ectodomain proteolysis|positive regulation of cytosolic calcium ion concentration|membrane|Golgi-associated vesicle membrane|positive regulation of protein binding|endoplasmic reticulum-Golgi intermediate compartment membrane|membrane protein proteolysis|positive regulation of protein dephosphorylation|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|intracellular membrane-bounded organelle|T cell receptor signaling pathway|positive regulation of calcineurin-NFAT signaling cascade|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane" SPR 442.4198495 473.9844372 410.8552617 0.866811712 -0.206209448 0.627443257 1 16.76371482 15.15692023 6697 sepiapterin reductase "GO:0004033,GO:0004757,GO:0005654,GO:0005829,GO:0006729,GO:0006809,GO:0050661,GO:0050999,GO:0055114,GO:0070062" aldo-keto reductase (NADP) activity|sepiapterin reductase activity|nucleoplasm|cytosol|tetrahydrobiopterin biosynthetic process|nitric oxide biosynthetic process|NADP binding|regulation of nitric-oxide synthase activity|oxidation-reduction process|extracellular exosome hsa00790 Folate biosynthesis SPRED1 1018.121578 1101.227226 935.0159313 0.849067213 -0.236049332 0.502291865 1 6.275826948 5.558133325 161742 sprouty related EVH1 domain containing 1 "GO:0000165,GO:0000188,GO:0005173,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0005901,GO:0006469,GO:0008543,GO:0010719,GO:0010801,GO:0010923,GO:0016525,GO:0019901,GO:0019902,GO:0030291,GO:0030512,GO:0031410,GO:0043408,GO:0043409,GO:0043517,GO:0060979,GO:0070373,GO:0090051,GO:0090311,GO:1902747" "MAPK cascade|inactivation of MAPK activity|stem cell factor receptor binding|protein binding|nucleoplasm|cytosol|plasma membrane|caveola|negative regulation of protein kinase activity|fibroblast growth factor receptor signaling pathway|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|negative regulation of phosphatase activity|negative regulation of angiogenesis|protein kinase binding|phosphatase binding|protein serine/threonine kinase inhibitor activity|negative regulation of transforming growth factor beta receptor signaling pathway|cytoplasmic vesicle|regulation of MAPK cascade|negative regulation of MAPK cascade|positive regulation of DNA damage response, signal transduction by p53 class mediator|vasculogenesis involved in coronary vascular morphogenesis|negative regulation of ERK1 and ERK2 cascade|negative regulation of cell migration involved in sprouting angiogenesis|regulation of protein deacetylation|negative regulation of lens fiber cell differentiation" SPRED2 1060.817277 1090.06271 1031.571844 0.946341742 -0.079566832 0.821775963 1 8.917433493 8.802454838 200734 sprouty related EVH1 domain containing 2 "GO:0000188,GO:0005173,GO:0005515,GO:0005829,GO:0005886,GO:0007275,GO:0008543,GO:0010719,GO:0010801,GO:0019901,GO:0030291,GO:0030512,GO:0030658,GO:0043517,GO:0070373,GO:0090311,GO:1902747" "inactivation of MAPK activity|stem cell factor receptor binding|protein binding|cytosol|plasma membrane|multicellular organism development|fibroblast growth factor receptor signaling pathway|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|protein kinase binding|protein serine/threonine kinase inhibitor activity|negative regulation of transforming growth factor beta receptor signaling pathway|transport vesicle membrane|positive regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of ERK1 and ERK2 cascade|regulation of protein deacetylation|negative regulation of lens fiber cell differentiation" SPRED3 252.1613805 264.9035077 239.4192532 0.903797973 -0.145927774 0.776299698 1 2.573154611 2.425789851 399473 sprouty related EVH1 domain containing 3 "GO:0000188,GO:0005886,GO:0007275,GO:0010719,GO:0010801,GO:0019901,GO:0030512,GO:0043517,GO:0070373,GO:0090311,GO:1902747" "inactivation of MAPK activity|plasma membrane|multicellular organism development|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|protein kinase binding|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of ERK1 and ERK2 cascade|regulation of protein deacetylation|negative regulation of lens fiber cell differentiation" SPRING1 1801.598055 1686.856819 1916.33929 1.136041464 0.184015492 0.57179442 1 10.13925315 12.01478708 79794 SREBF pathway regulator in golgi 1 "GO:0000139,GO:0005515,GO:0016021,GO:2000640" Golgi membrane|protein binding|integral component of membrane|positive regulation of SREBP signaling pathway SPRTN 358.6953846 374.5187523 342.872017 0.915500265 -0.127367791 0.780710185 1 5.044695102 4.817362492 83932 SprT-like N-terminal domain "GO:0000785,GO:0003690,GO:0003697,GO:0004222,GO:0005515,GO:0005634,GO:0005654,GO:0006508,GO:0006974,GO:0009411,GO:0016540,GO:0016607,GO:0019985,GO:0031398,GO:0031593,GO:0043130,GO:0046872,GO:0070530,GO:0070987,GO:0106300" chromatin|double-stranded DNA binding|single-stranded DNA binding|metalloendopeptidase activity|protein binding|nucleus|nucleoplasm|proteolysis|cellular response to DNA damage stimulus|response to UV|protein autoprocessing|nuclear speck|translesion synthesis|positive regulation of protein ubiquitination|polyubiquitin modification-dependent protein binding|ubiquitin binding|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|error-free translesion synthesis|protein-DNA covalent cross-linking repair SPRY1 75.18369214 121.7947162 28.57266808 0.234596943 -2.091743882 0.006739837 0.334242214 2.06579796 0.505505776 10252 sprouty RTK signaling antagonist 1 "GO:0000132,GO:0001656,GO:0001657,GO:0001759,GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0008285,GO:0010719,GO:0030512,GO:0034260,GO:0040037,GO:0042059,GO:0043407,GO:0046580,GO:0048513,GO:0051387,GO:0060449,GO:0060940,GO:0070373,GO:1902747" establishment of mitotic spindle orientation|metanephros development|ureteric bud development|organ induction|protein binding|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|negative regulation of cell population proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of GTPase activity|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of Ras protein signal transduction|animal organ development|negative regulation of neurotrophin TRK receptor signaling pathway|bud elongation involved in lung branching|epithelial to mesenchymal transition involved in cardiac fibroblast development|negative regulation of ERK1 and ERK2 cascade|negative regulation of lens fiber cell differentiation SPRY2 822.3578022 852.5630134 792.1525909 0.929142572 -0.106028108 0.774076768 1 12.46515848 12.08081109 10253 sprouty RTK signaling antagonist 2 "GO:0000132,GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0005886,GO:0007605,GO:0008285,GO:0010628,GO:0010719,GO:0010801,GO:0015629,GO:0015630,GO:0016020,GO:0016525,GO:0019901,GO:0030291,GO:0030335,GO:0030512,GO:0031345,GO:0031397,GO:0032587,GO:0033138,GO:0034260,GO:0035924,GO:0040037,GO:0042059,GO:0042472,GO:0043066,GO:0043407,GO:0043539,GO:0045165,GO:0046580,GO:0048513,GO:0051387,GO:0051897,GO:0060437,GO:0060449,GO:0070373,GO:0070374,GO:0071902,GO:1900747,GO:1902747,GO:1990752,GO:1990830" establishment of mitotic spindle orientation|protein binding|nucleus|cytosol|cytoskeleton|plasma membrane|sensory perception of sound|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|actin cytoskeleton|microtubule cytoskeleton|membrane|negative regulation of angiogenesis|protein kinase binding|protein serine/threonine kinase inhibitor activity|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of cell projection organization|negative regulation of protein ubiquitination|ruffle membrane|positive regulation of peptidyl-serine phosphorylation|negative regulation of GTPase activity|cellular response to vascular endothelial growth factor stimulus|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|inner ear morphogenesis|negative regulation of apoptotic process|negative regulation of MAP kinase activity|protein serine/threonine kinase activator activity|cell fate commitment|negative regulation of Ras protein signal transduction|animal organ development|negative regulation of neurotrophin TRK receptor signaling pathway|positive regulation of protein kinase B signaling|lung growth|bud elongation involved in lung branching|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein serine/threonine kinase activity|negative regulation of vascular endothelial growth factor signaling pathway|negative regulation of lens fiber cell differentiation|microtubule end|cellular response to leukemia inhibitory factor hsa05206 MicroRNAs in cancer SPRY3 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.039291065 0.022734075 10251 sprouty RTK signaling antagonist 3 "GO:0003674,GO:0005515,GO:0005829,GO:0007275,GO:0016020,GO:0040037,GO:0043407,GO:0043409,GO:0046580,GO:0048513,GO:0061564,GO:0070373,GO:0150013" molecular_function|protein binding|cytosol|multicellular organism development|membrane|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|negative regulation of Ras protein signal transduction|animal organ development|axon development|negative regulation of ERK1 and ERK2 cascade|negative regulation of neuron projection arborization SPRY4 1660.966032 1233.171502 2088.760563 1.693811899 0.76027367 0.020797315 0.622266675 8.721657057 15.40920082 81848 sprouty RTK signaling antagonist 4 "GO:0004860,GO:0005515,GO:0005737,GO:0005829,GO:0005925,GO:0032587,GO:0040037,GO:0043407,GO:0046580,GO:0048513,GO:0070373,GO:1900025" protein kinase inhibitor activity|protein binding|cytoplasm|cytosol|focal adhesion|ruffle membrane|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of Ras protein signal transduction|animal organ development|negative regulation of ERK1 and ERK2 cascade|negative regulation of substrate adhesion-dependent cell spreading SPRYD3 761.2822948 718.5888256 803.9757639 1.118825864 0.161985511 0.664323839 1 12.54100241 14.63560496 84926 SPRY domain containing 3 "GO:0005737,GO:0007010,GO:0007166" cytoplasm|cytoskeleton organization|cell surface receptor signaling pathway SPRYD4 365.8324896 357.2645009 374.4004783 1.0479644 0.067589708 0.885121754 1 1.680210476 1.836648919 283377 SPRY domain containing 4 "GO:0003674,GO:0005515,GO:0005634,GO:0008150" molecular_function|protein binding|nucleus|biological_process SPRYD7 261.3256758 285.2026271 237.4487244 0.832561491 -0.264371265 0.595988453 1 3.330529612 2.892314723 57213 SPRY domain containing 7 GO:0005515 protein binding SPSB1 965.0130556 1208.812558 721.2135529 0.596629765 -0.745092141 0.036140267 0.858303341 19.71091167 12.26669473 80176 splA/ryanodine receptor domain and SOCS box containing 1 "GO:0000209,GO:0005515,GO:0005829,GO:0006511,GO:0016567,GO:0019005,GO:0043161,GO:0043687,GO:1990756" protein polyubiquitination|protein binding|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|SCF ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin ligase-substrate adaptor activity SPSB2 244.4749818 244.6043884 244.3455753 0.998941912 -0.001527307 1 1 8.537801074 8.896152033 84727 splA/ryanodine receptor domain and SOCS box containing 2 "GO:0005515,GO:0005829,GO:0006511,GO:0016032,GO:0016567,GO:0019005,GO:0035556,GO:0043161,GO:0043687,GO:1990756" protein binding|cytosol|ubiquitin-dependent protein catabolic process|viral process|protein ubiquitination|SCF ubiquitin ligase complex|intracellular signal transduction|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin ligase-substrate adaptor activity SPSB3 505.8439572 364.3691926 647.3187217 1.776546247 0.829075245 0.042540704 0.940614529 10.5271045 19.50748948 90864 splA/ryanodine receptor domain and SOCS box containing 3 "GO:0005515,GO:0005829,GO:0016567,GO:0019005,GO:0043161,GO:0043687" protein binding|cytosol|protein ubiquitination|SCF ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification SPTAN1 7204.477852 5505.121172 8903.834532 1.617373034 0.693652463 0.035249782 0.844126412 34.8257515 58.75253696 6709 "spectrin alpha, non-erythrocytic 1" "GO:0000165,GO:0003779,GO:0005200,GO:0005509,GO:0005515,GO:0005516,GO:0005576,GO:0005829,GO:0006888,GO:0007010,GO:0007411,GO:0008091,GO:0015630,GO:0016020,GO:0035580,GO:0043231,GO:0043312,GO:0045296,GO:0051693,GO:0070062,GO:1903561,GO:1904724" MAPK cascade|actin binding|structural constituent of cytoskeleton|calcium ion binding|protein binding|calmodulin binding|extracellular region|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|axon guidance|spectrin|microtubule cytoskeleton|membrane|specific granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|cadherin binding|actin filament capping|extracellular exosome|extracellular vesicle|tertiary granule lumen hsa04210 Apoptosis SPTB 82.33836445 72.06187375 92.61485516 1.285212975 0.362007451 0.624631294 1 0.273876609 0.367152063 6710 "spectrin beta, erythrocytic" "GO:0000165,GO:0003779,GO:0005200,GO:0005515,GO:0005829,GO:0006888,GO:0007010,GO:0007411,GO:0008091,GO:0014731,GO:0015629,GO:0030506,GO:0031235,GO:0032991,GO:0051015,GO:0051693" MAPK cascade|actin binding|structural constituent of cytoskeleton|protein binding|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|axon guidance|spectrin|spectrin-associated cytoskeleton|actin cytoskeleton|ankyrin binding|intrinsic component of the cytoplasmic side of the plasma membrane|protein-containing complex|actin filament binding|actin filament capping SPTBN1 6734.65024 6862.117302 6607.183177 0.962849058 -0.054618445 0.867579105 1 27.63094556 27.75044083 6711 "spectrin beta, non-erythrocytic 1" "GO:0000165,GO:0000281,GO:0003723,GO:0003779,GO:0005200,GO:0005515,GO:0005516,GO:0005543,GO:0005730,GO:0005737,GO:0005829,GO:0006888,GO:0007009,GO:0007010,GO:0007411,GO:0008091,GO:0014731,GO:0030506,GO:0030673,GO:0031430,GO:0032743,GO:0043001,GO:0045296,GO:0051020,GO:0051693,GO:0070062,GO:0071709,GO:0072659,GO:1903076,GO:1903078" MAPK cascade|mitotic cytokinesis|RNA binding|actin binding|structural constituent of cytoskeleton|protein binding|calmodulin binding|phospholipid binding|nucleolus|cytoplasm|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|plasma membrane organization|cytoskeleton organization|axon guidance|spectrin|spectrin-associated cytoskeleton|ankyrin binding|axolemma|M band|positive regulation of interleukin-2 production|Golgi to plasma membrane protein transport|cadherin binding|GTPase binding|actin filament capping|extracellular exosome|membrane assembly|protein localization to plasma membrane|regulation of protein localization to plasma membrane|positive regulation of protein localization to plasma membrane SPTBN2 565.8909006 663.7812033 468.0005979 0.705052502 -0.504197404 0.203540151 1 2.133809982 1.569253587 6712 "spectrin beta, non-erythrocytic 2" "GO:0000165,GO:0003779,GO:0005200,GO:0005543,GO:0005615,GO:0005829,GO:0006888,GO:0007010,GO:0007411,GO:0007416,GO:0008091,GO:0016192,GO:0016324,GO:0019886,GO:0021692,GO:0030534,GO:0035264,GO:0043025,GO:0045296,GO:0051693,GO:0098688,GO:0098793,GO:0098918,GO:0098978,GO:0099173,GO:0099189" MAPK cascade|actin binding|structural constituent of cytoskeleton|phospholipid binding|extracellular space|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|axon guidance|synapse assembly|spectrin|vesicle-mediated transport|apical plasma membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|cerebellar Purkinje cell layer morphogenesis|adult behavior|multicellular organism growth|neuronal cell body|cadherin binding|actin filament capping|parallel fiber to Purkinje cell synapse|presynapse|structural constituent of synapse|glutamatergic synapse|postsynapse organization|postsynaptic spectrin-associated cytoskeleton "hsa05017,hsa05022" Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases SPTBN4 38.39289909 31.46363502 45.32216316 1.440461763 0.526531364 0.578221671 1 0.149052672 0.223953281 57731 "spectrin beta, non-erythrocytic 4" "GO:0000165,GO:0002028,GO:0003779,GO:0005200,GO:0005515,GO:0005543,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005912,GO:0006888,GO:0007010,GO:0007409,GO:0007411,GO:0007605,GO:0007628,GO:0008091,GO:0009566,GO:0010459,GO:0014704,GO:0016020,GO:0016192,GO:0016363,GO:0016605,GO:0019226,GO:0019902,GO:0021952,GO:0030506,GO:0030507,GO:0033135,GO:0033268,GO:0033270,GO:0040018,GO:0043025,GO:0043194,GO:0043203,GO:0045162,GO:0051693,GO:0061337,GO:0070062,GO:0070852,GO:0072659,GO:0106006" MAPK cascade|regulation of sodium ion transport|actin binding|structural constituent of cytoskeleton|protein binding|phospholipid binding|cytoplasm|cytosol|actin filament|plasma membrane|adherens junction|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|axonogenesis|axon guidance|sensory perception of sound|adult walking behavior|spectrin|fertilization|negative regulation of heart rate|intercalated disc|membrane|vesicle-mediated transport|nuclear matrix|PML body|transmission of nerve impulse|phosphatase binding|central nervous system projection neuron axonogenesis|ankyrin binding|spectrin binding|regulation of peptidyl-serine phosphorylation|node of Ranvier|paranode region of axon|positive regulation of multicellular organism growth|neuronal cell body|axon initial segment|axon hillock|clustering of voltage-gated sodium channels|actin filament capping|cardiac conduction|extracellular exosome|cell body fiber|protein localization to plasma membrane|cytoskeletal protein-membrane anchor activity SPTBN5 29.62943977 38.5683268 20.69055275 0.536464878 -0.898444372 0.369819349 1 0.151740052 0.084909729 51332 "spectrin beta, non-erythrocytic 5" "GO:0000165,GO:0002046,GO:0003779,GO:0005737,GO:0005829,GO:0005875,GO:0006888,GO:0007030,GO:0007041,GO:0007411,GO:0008022,GO:0008091,GO:0016020,GO:0019894,GO:0030036,GO:0030507,GO:0032029,GO:0032391,GO:0034452,GO:0042802,GO:0043621,GO:0045179,GO:0045505,GO:0051015,GO:0051693,GO:0097381" MAPK cascade|opsin binding|actin binding|cytoplasm|cytosol|microtubule associated complex|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|lysosomal transport|axon guidance|protein C-terminus binding|spectrin|membrane|kinesin binding|actin cytoskeleton organization|spectrin binding|myosin tail binding|photoreceptor connecting cilium|dynactin binding|identical protein binding|protein self-association|apical cortex|dynein intermediate chain binding|actin filament binding|actin filament capping|photoreceptor disc membrane SPTLC1 1857.924152 1664.527788 2051.320515 1.232373848 0.301439973 0.352495429 1 16.83355838 21.6388578 10558 serine palmitoyltransferase long chain base subunit 1 "GO:0004758,GO:0005515,GO:0005783,GO:0005789,GO:0006665,GO:0016021,GO:0017059,GO:0030148,GO:0030170,GO:0035339,GO:0046512,GO:0046513,GO:1904504,GO:1904649" serine C-palmitoyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|sphingolipid metabolic process|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|pyridoxal phosphate binding|SPOTS complex|sphingosine biosynthetic process|ceramide biosynthetic process|positive regulation of lipophagy|regulation of fat cell apoptotic process "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SPTLC2 2755.429273 2535.360009 2975.498538 1.173600012 0.230940791 0.468520814 1 15.16738014 18.56720817 9517 serine palmitoyltransferase long chain base subunit 2 "GO:0004758,GO:0005789,GO:0006686,GO:0016021,GO:0017059,GO:0030148,GO:0030170,GO:0046511,GO:0046512,GO:0046513,GO:0060612,GO:1904504" serine C-palmitoyltransferase activity|endoplasmic reticulum membrane|sphingomyelin biosynthetic process|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|pyridoxal phosphate binding|sphinganine biosynthetic process|sphingosine biosynthetic process|ceramide biosynthetic process|adipose tissue development|positive regulation of lipophagy "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SPTSSA 773.3551243 769.336624 777.3736247 1.010446663 0.014993171 0.971516717 1 14.6371848 15.42719184 171546 serine palmitoyltransferase small subunit A "GO:0004758,GO:0005515,GO:0005783,GO:0005789,GO:0008104,GO:0016021,GO:0017059,GO:0030148,GO:0046513" serine C-palmitoyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein localization|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|ceramide biosynthetic process SPTY2D1 937.545902 1014.955968 860.1358356 0.847461232 -0.238780722 0.503643286 1 8.960073078 7.920403768 144108 SPT2 chromatin protein domain containing 1 "GO:0001042,GO:0003677,GO:0005654,GO:0005730,GO:0006334,GO:0006355,GO:0010847,GO:0042393,GO:0043486" "RNA polymerase I core binding|DNA binding|nucleoplasm|nucleolus|nucleosome assembly|regulation of transcription, DNA-templated|regulation of chromatin assembly|histone binding|histone exchange" SPTY2D1OS 12.98658673 12.17947162 13.79370183 1.132536966 0.17955814 0.952676516 1 1.346828103 1.591037755 100506540 SPTY2D1 opposite strand GO:0016021 integral component of membrane SPX 7.493403555 7.104691779 7.882115332 1.109423966 0.149810797 1 1 0.157819112 0.182630399 80763 spexin hormone "GO:0003084,GO:0005184,GO:0005515,GO:0005615,GO:0005737,GO:0007165,GO:0010459,GO:0030133,GO:0031045,GO:0032099,GO:0035814,GO:0044539,GO:0051930,GO:1904306" positive regulation of systemic arterial blood pressure|neuropeptide hormone activity|protein binding|extracellular space|cytoplasm|signal transduction|negative regulation of heart rate|transport vesicle|dense core granule|negative regulation of appetite|negative regulation of renal sodium excretion|long-chain fatty acid import into cell|regulation of sensory perception of pain|positive regulation of gastro-intestinal system smooth muscle contraction SQLE 1497.800851 1226.06681 1769.534892 1.443261393 0.529332614 0.110791632 1 18.94902613 28.52645591 6713 squalene epoxidase "GO:0004506,GO:0005515,GO:0005783,GO:0005789,GO:0006695,GO:0006725,GO:0008203,GO:0010033,GO:0016021,GO:0016126,GO:0042127,GO:0043231,GO:0045540,GO:0055114,GO:0071949,GO:0140042" squalene monooxygenase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|cellular aromatic compound metabolic process|cholesterol metabolic process|response to organic substance|integral component of membrane|sterol biosynthetic process|regulation of cell population proliferation|intracellular membrane-bounded organelle|regulation of cholesterol biosynthetic process|oxidation-reduction process|FAD binding|lipid droplet formation hsa00100 Steroid biosynthesis SQOR 676.4253455 777.4562718 575.3944193 0.740098756 -0.434210304 0.253976702 1 20.97784628 16.19446116 58472 sulfide quinone oxidoreductase "GO:0005739,GO:0005743,GO:0048038,GO:0070221,GO:0070224,GO:0070813,GO:0071949" "mitochondrion|mitochondrial inner membrane|quinone binding|sulfide oxidation, using sulfide:quinone oxidoreductase|sulfide:quinone oxidoreductase activity|hydrogen sulfide metabolic process|FAD binding" hsa00920 Sulfur metabolism SQSTM1 7776.690831 7914.626641 7638.755021 0.965144077 -0.051183771 0.877012114 1 122.8464353 123.6717875 8878 sequestosome 1 "GO:0000122,GO:0000407,GO:0000422,GO:0000423,GO:0000932,GO:0001934,GO:0002376,GO:0002931,GO:0004674,GO:0005080,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005770,GO:0005776,GO:0005783,GO:0005829,GO:0006468,GO:0006511,GO:0006914,GO:0006915,GO:0007032,GO:0008104,GO:0008270,GO:0010821,GO:0016197,GO:0016234,GO:0016235,GO:0016236,GO:0016605,GO:0019899,GO:0019901,GO:0030017,GO:0030154,GO:0030971,GO:0031397,GO:0031625,GO:0035255,GO:0035556,GO:0035973,GO:0042169,GO:0042802,GO:0043065,GO:0043066,GO:0043122,GO:0043130,GO:0043231,GO:0044753,GO:0044754,GO:0044877,GO:0045944,GO:0046578,GO:0061635,GO:0061912,GO:0070062,GO:0070498,GO:0070530,GO:0097225,GO:0097413,GO:0098780,GO:1900273,GO:1903078,GO:1905719" negative regulation of transcription by RNA polymerase II|phagophore assembly site|autophagy of mitochondrion|mitophagy|P-body|positive regulation of protein phosphorylation|immune system process|response to ischemia|protein serine/threonine kinase activity|protein kinase C binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|late endosome|autophagosome|endoplasmic reticulum|cytosol|protein phosphorylation|ubiquitin-dependent protein catabolic process|autophagy|apoptotic process|endosome organization|protein localization|zinc ion binding|regulation of mitochondrion organization|endosomal transport|inclusion body|aggresome|macroautophagy|PML body|enzyme binding|protein kinase binding|sarcomere|cell differentiation|receptor tyrosine kinase binding|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|ionotropic glutamate receptor binding|intracellular signal transduction|aggrephagy|SH2 domain binding|identical protein binding|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|intracellular membrane-bounded organelle|amphisome|autolysosome|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|regulation of Ras protein signal transduction|regulation of protein complex stability|selective autophagy|extracellular exosome|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|sperm midpiece|Lewy body|response to mitochondrial depolarisation|positive regulation of long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|protein localization to perinuclear region of cytoplasm "hsa04137,hsa04140,hsa04217,hsa04218,hsa04380,hsa05014,hsa05022,hsa05131,hsa05418" Mitophagy - animal|Autophagy - animal|Necroptosis|Cellular senescence|Osteoclast differentiation|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Fluid shear stress and atherosclerosis SRA1 764.3459678 860.6826612 668.0092744 0.776138877 -0.365613273 0.324331119 1 29.3934865 23.79613755 10011 steroid receptor RNA activator 1 "GO:0002153,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006915,GO:0007346,GO:0015630,GO:0030154,GO:0030374,GO:0031209,GO:0031252,GO:0042981,GO:0045171,GO:0045662,GO:0045893,GO:0071391,GO:1990904" "steroid receptor RNA activator RNA binding|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|apoptotic process|regulation of mitotic cell cycle|microtubule cytoskeleton|cell differentiation|nuclear receptor coactivator activity|SCAR complex|cell leading edge|regulation of apoptotic process|intercellular bridge|negative regulation of myoblast differentiation|positive regulation of transcription, DNA-templated|cellular response to estrogen stimulus|ribonucleoprotein complex" SRBD1 263.6525032 309.5615704 217.7434361 0.703392982 -0.507597154 0.303512609 1 3.340051442 2.450570021 55133 S1 RNA binding domain 1 "GO:0003729,GO:0003735,GO:0006139,GO:0006412" mRNA binding|structural constituent of ribosome|nucleobase-containing compound metabolic process|translation SRC 3305.889231 3322.96584 3288.812622 0.989722068 -0.014904648 0.963639483 1 36.6260059 37.81105059 6714 "SRC proto-oncogene, non-receptor tyrosine kinase" "GO:0001545,GO:0002102,GO:0002223,GO:0004672,GO:0004713,GO:0004715,GO:0005080,GO:0005102,GO:0005158,GO:0005178,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005764,GO:0005770,GO:0005829,GO:0005884,GO:0005886,GO:0005901,GO:0005925,GO:0007049,GO:0007155,GO:0007165,GO:0007169,GO:0007172,GO:0007173,GO:0007179,GO:0007186,GO:0007229,GO:0007411,GO:0008022,GO:0008283,GO:0009612,GO:0009615,GO:0010447,GO:0010632,GO:0010634,GO:0010907,GO:0010954,GO:0014068,GO:0014069,GO:0014911,GO:0016032,GO:0016236,GO:0016301,GO:0018105,GO:0018108,GO:0019899,GO:0019900,GO:0020037,GO:0022407,GO:0030054,GO:0030154,GO:0030168,GO:0030331,GO:0030900,GO:0031234,GO:0031295,GO:0031333,GO:0031625,GO:0031648,GO:0031667,GO:0031954,GO:0032148,GO:0032211,GO:0032587,GO:0032869,GO:0033146,GO:0033625,GO:0034332,GO:0034446,GO:0035306,GO:0035556,GO:0035635,GO:0036035,GO:0036120,GO:0038083,GO:0038096,GO:0038128,GO:0042127,GO:0042169,GO:0042476,GO:0042493,GO:0043005,GO:0043065,GO:0043066,GO:0043114,GO:0043149,GO:0043154,GO:0043393,GO:0043406,GO:0043552,GO:0044325,GO:0045056,GO:0045087,GO:0045121,GO:0045124,GO:0045296,GO:0045453,GO:0045737,GO:0045747,GO:0045892,GO:0045893,GO:0046628,GO:0046777,GO:0046875,GO:0048010,GO:0048011,GO:0048013,GO:0048041,GO:0048471,GO:0048477,GO:0050731,GO:0050847,GO:0050900,GO:0051057,GO:0051117,GO:0051219,GO:0051222,GO:0051385,GO:0051602,GO:0051895,GO:0051897,GO:0051902,GO:0051974,GO:0060065,GO:0060444,GO:0060491,GO:0060576,GO:0070062,GO:0070102,GO:0070301,GO:0070374,GO:0070555,GO:0070700,GO:0070851,GO:0071222,GO:0071253,GO:0071375,GO:0071393,GO:0071398,GO:0071456,GO:0071498,GO:0071803,GO:0071902,GO:0086098,GO:0090263,GO:0097110,GO:0098609,GO:0098962,GO:0098978,GO:0099091,GO:1900182,GO:1903997,GO:2000386,GO:2000394,GO:2000573,GO:2000588,GO:2000641,GO:2000811,GO:2001237,GO:2001243,GO:2001286" "primary ovarian follicle growth|podosome|stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein kinase C binding|signaling receptor binding|insulin receptor binding|integrin binding|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|lysosome|late endosome|cytosol|actin filament|plasma membrane|caveola|focal adhesion|cell cycle|cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|signal complex assembly|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|G protein-coupled receptor signaling pathway|integrin-mediated signaling pathway|axon guidance|protein C-terminus binding|cell population proliferation|response to mechanical stimulus|response to virus|response to acidic pH|regulation of epithelial cell migration|positive regulation of epithelial cell migration|positive regulation of glucose metabolic process|positive regulation of protein processing|positive regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|positive regulation of smooth muscle cell migration|viral process|macroautophagy|kinase activity|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|enzyme binding|kinase binding|heme binding|regulation of cell-cell adhesion|cell junction|cell differentiation|platelet activation|estrogen receptor binding|forebrain development|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|negative regulation of protein-containing complex assembly|ubiquitin protein ligase binding|protein destabilization|response to nutrient levels|positive regulation of protein autophosphorylation|activation of protein kinase B activity|negative regulation of telomere maintenance via telomerase|ruffle membrane|cellular response to insulin stimulus|regulation of intracellular estrogen receptor signaling pathway|positive regulation of integrin activation|adherens junction organization|substrate adhesion-dependent cell spreading|positive regulation of dephosphorylation|intracellular signal transduction|entry of bacterium into host cell|osteoclast development|cellular response to platelet-derived growth factor stimulus|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|regulation of cell population proliferation|SH2 domain binding|odontogenesis|response to drug|neuron projection|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of vascular permeability|stress fiber assembly|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of protein binding|positive regulation of MAP kinase activity|positive regulation of phosphatidylinositol 3-kinase activity|ion channel binding|transcytosis|innate immune response|membrane raft|regulation of bone resorption|cadherin binding|bone resorption|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of insulin receptor signaling pathway|protein autophosphorylation|ephrin receptor binding|vascular endothelial growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|ephrin receptor signaling pathway|focal adhesion assembly|perinuclear region of cytoplasm|oogenesis|positive regulation of peptidyl-tyrosine phosphorylation|progesterone receptor signaling pathway|leukocyte migration|positive regulation of small GTPase mediated signal transduction|ATPase binding|phosphoprotein binding|positive regulation of protein transport|response to mineralocorticoid|response to electrical stimulus|negative regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of mitochondrial depolarization|negative regulation of telomerase activity|uterus development|branching involved in mammary gland duct morphogenesis|regulation of cell projection assembly|intestinal epithelial cell development|extracellular exosome|interleukin-6-mediated signaling pathway|cellular response to hydrogen peroxide|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|BMP receptor binding|growth factor receptor binding|cellular response to lipopolysaccharide|connexin binding|cellular response to peptide hormone stimulus|cellular response to progesterone stimulus|cellular response to fatty acid|cellular response to hypoxia|cellular response to fluid shear stress|positive regulation of podosome assembly|positive regulation of protein serine/threonine kinase activity|angiotensin-activated signaling pathway involved in heart process|positive regulation of canonical Wnt signaling pathway|scaffold protein binding|cell-cell adhesion|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse|postsynaptic specialization, intracellular component|positive regulation of protein localization to nucleus|positive regulation of non-membrane spanning protein tyrosine kinase activity|positive regulation of ovarian follicle development|positive regulation of lamellipodium morphogenesis|positive regulation of DNA biosynthetic process|positive regulation of platelet-derived growth factor receptor-beta signaling pathway|regulation of early endosome to late endosome transport|negative regulation of anoikis|negative regulation of extrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway|regulation of caveolin-mediated endocytosis" "hsa01521,hsa01522,hsa04012,hsa04015,hsa04062,hsa04137,hsa04144,hsa04360,hsa04370,hsa04510,hsa04520,hsa04530,hsa04540,hsa04611,hsa04625,hsa04727,hsa04750,hsa04810,hsa04912,hsa04915,hsa04917,hsa04919,hsa04921,hsa04926,hsa05100,hsa05120,hsa05130,hsa05131,hsa05135,hsa05152,hsa05161,hsa05163,hsa05167,hsa05168,hsa05203,hsa05205,hsa05219,hsa05418" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Mitophagy - animal|Endocytosis|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Tight junction|Gap junction|Platelet activation|C-type lectin receptor signaling pathway|GABAergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Yersinia infection|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Viral carcinogenesis|Proteoglycans in cancer|Bladder cancer|Fluid shear stress and atherosclerosis other SRCAP 4797.859406 4655.603027 4940.115785 1.061111902 0.085576808 0.789882147 1 20.11172546 22.260066 10847 Snf2 related CREBBP activator protein "GO:0000812,GO:0003677,GO:0003713,GO:0004386,GO:0004402,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0006357,GO:0016032,GO:0016458,GO:0016573,GO:0016604,GO:0016887,GO:0032991,GO:0042393,GO:0043044,GO:0043486,GO:0045893,GO:0048471" "Swr1 complex|DNA binding|transcription coactivator activity|helicase activity|histone acetyltransferase activity|protein binding|ATP binding|nucleus|nucleoplasm|Golgi apparatus|regulation of transcription by RNA polymerase II|viral process|gene silencing|histone acetylation|nuclear body|ATPase activity|protein-containing complex|histone binding|ATP-dependent chromatin remodeling|histone exchange|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm" SRCIN1 118.9537298 116.7199364 121.1875232 1.038276125 0.054190173 0.94642968 1 0.55273053 0.598607633 80725 SRC kinase signaling inhibitor 1 "GO:0005515,GO:0005737,GO:0005925,GO:0006887,GO:0014069,GO:0015629,GO:0019901,GO:0030234,GO:0030334,GO:0030424,GO:0030425,GO:0034446,GO:0045202,GO:0061001,GO:0061098,GO:0061099,GO:0098793" protein binding|cytoplasm|focal adhesion|exocytosis|postsynaptic density|actin cytoskeleton|protein kinase binding|enzyme regulator activity|regulation of cell migration|axon|dendrite|substrate adhesion-dependent cell spreading|synapse|regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|negative regulation of protein tyrosine kinase activity|presynapse SRD5A1 973.9737155 979.4325095 968.5149215 0.988853149 -0.016171807 0.966725679 1 6.58150476 6.788486059 6715 steroid 5 alpha-reductase 1 "GO:0001655,GO:0001889,GO:0003865,GO:0005789,GO:0006694,GO:0006702,GO:0006710,GO:0007530,GO:0008584,GO:0009055,GO:0009267,GO:0014850,GO:0016021,GO:0016101,GO:0016491,GO:0021510,GO:0021766,GO:0021794,GO:0021854,GO:0021983,GO:0021987,GO:0022900,GO:0030154,GO:0030539,GO:0030540,GO:0032354,GO:0032869,GO:0033218,GO:0042428,GO:0042448,GO:0042493,GO:0042747,GO:0043025,GO:0043209,GO:0043627,GO:0047751,GO:0048471,GO:0060348,GO:0060416,GO:0060992,GO:0070402,GO:0070852,GO:0071320,GO:0071363,GO:0071392,GO:0071394,GO:0071549,GO:0071872" "urogenital system development|liver development|3-oxo-5-alpha-steroid 4-dehydrogenase activity|endoplasmic reticulum membrane|steroid biosynthetic process|androgen biosynthetic process|androgen catabolic process|sex determination|male gonad development|electron transfer activity|cellular response to starvation|response to muscle activity|integral component of membrane|diterpenoid metabolic process|oxidoreductase activity|spinal cord development|hippocampus development|thalamus development|hypothalamus development|pituitary gland development|cerebral cortex development|electron transport chain|cell differentiation|male genitalia development|female genitalia development|response to follicle-stimulating hormone|cellular response to insulin stimulus|amide binding|serotonin metabolic process|progesterone metabolic process|response to drug|circadian sleep/wake cycle, REM sleep|neuronal cell body|myelin sheath|response to estrogen|cholestenone 5-alpha-reductase activity|perinuclear region of cytoplasm|bone development|response to growth hormone|response to fungicide|NADPH binding|cell body fiber|cellular response to cAMP|cellular response to growth factor stimulus|cellular response to estradiol stimulus|cellular response to testosterone stimulus|cellular response to dexamethasone stimulus|cellular response to epinephrine stimulus" hsa00140 Steroid hormone biosynthesis SRD5A3 103.2488822 120.7797602 85.71800424 0.709705037 -0.494708549 0.464168882 1 2.410192581 1.78420833 79644 steroid 5 alpha-reductase 3 "GO:0003865,GO:0005783,GO:0005789,GO:0006488,GO:0006489,GO:0006702,GO:0016021,GO:0016095,GO:0016628,GO:0019348,GO:0019408,GO:0047751,GO:0055114,GO:0102389" "3-oxo-5-alpha-steroid 4-dehydrogenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|dolichyl diphosphate biosynthetic process|androgen biosynthetic process|integral component of membrane|polyprenol catabolic process|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|dolichol metabolic process|dolichol biosynthetic process|cholestenone 5-alpha-reductase activity|oxidation-reduction process|polyprenol reductase activity" "hsa00140,hsa00510" Steroid hormone biosynthesis|N-Glycan biosynthesis SREBF1 930.7717767 1158.06476 703.4787934 0.607460669 -0.719137094 0.04442708 0.957336478 11.52522985 7.302703849 6720 sterol regulatory element binding transcription factor 1 "GO:0000122,GO:0000139,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003062,GO:0003677,GO:0003682,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0006357,GO:0006629,GO:0007568,GO:0007623,GO:0008203,GO:0008286,GO:0008610,GO:0009267,GO:0009749,GO:0010867,GO:0010876,GO:0010883,GO:0012507,GO:0016021,GO:0019217,GO:0019901,GO:0030324,GO:0030522,GO:0031065,GO:0031647,GO:0032094,GO:0032526,GO:0032570,GO:0032810,GO:0032933,GO:0032991,GO:0033762,GO:0042493,GO:0042789,GO:0044877,GO:0045444,GO:0045471,GO:0045540,GO:0045542,GO:0045944,GO:0046676,GO:0046983,GO:0051591,GO:0071398,GO:1903146,GO:1903214,GO:1990837" "negative regulation of transcription by RNA polymerase II|Golgi membrane|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|regulation of heart rate by chemical signal|DNA binding|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|regulation of transcription by RNA polymerase II|lipid metabolic process|aging|circadian rhythm|cholesterol metabolic process|insulin receptor signaling pathway|lipid biosynthetic process|cellular response to starvation|response to glucose|positive regulation of triglyceride biosynthetic process|lipid localization|regulation of lipid storage|ER to Golgi transport vesicle membrane|integral component of membrane|regulation of fatty acid metabolic process|protein kinase binding|lung development|intracellular receptor signaling pathway|positive regulation of histone deacetylation|regulation of protein stability|response to food|response to retinoic acid|response to progesterone|sterol response element binding|SREBP signaling pathway|protein-containing complex|response to glucagon|response to drug|mRNA transcription by RNA polymerase II|protein-containing complex binding|fat cell differentiation|response to ethanol|regulation of cholesterol biosynthetic process|positive regulation of cholesterol biosynthetic process|positive regulation of transcription by RNA polymerase II|negative regulation of insulin secretion|protein dimerization activity|response to cAMP|cellular response to fatty acid|regulation of autophagy of mitochondrion|regulation of protein targeting to mitochondrion|sequence-specific double-stranded DNA binding" "hsa04152,hsa04910,hsa04931,hsa04932" AMPK signaling pathway|Insulin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease bHLH SREBF2 3937.490735 3662.97609 4212.005381 1.149886125 0.201490996 0.527295048 1 25.40630194 30.47278997 6721 sterol regulatory element binding transcription factor 2 "GO:0000122,GO:0000139,GO:0000247,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006357,GO:0006629,GO:0008022,GO:0008203,GO:0008593,GO:0009267,GO:0010886,GO:0012507,GO:0032933,GO:0032937,GO:0042632,GO:0043231,GO:0045540,GO:0045944,GO:0046983,GO:0070888,GO:0071404,GO:0071499,GO:0090370,GO:1902895,GO:1903146,GO:1903955,GO:1990837" "negative regulation of transcription by RNA polymerase II|Golgi membrane|C-8 sterol isomerase activity|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|regulation of transcription by RNA polymerase II|lipid metabolic process|protein C-terminus binding|cholesterol metabolic process|regulation of Notch signaling pathway|cellular response to starvation|positive regulation of cholesterol storage|ER to Golgi transport vesicle membrane|SREBP signaling pathway|SREBP-SCAP-Insig complex|cholesterol homeostasis|intracellular membrane-bounded organelle|regulation of cholesterol biosynthetic process|positive regulation of transcription by RNA polymerase II|protein dimerization activity|E-box binding|cellular response to low-density lipoprotein particle stimulus|cellular response to laminar fluid shear stress|negative regulation of cholesterol efflux|positive regulation of pri-miRNA transcription by RNA polymerase II|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|sequence-specific double-stranded DNA binding" bHLH SREK1 1180.433624 1319.442759 1041.424488 0.789291147 -0.341370528 0.31964733 1 8.380376351 6.899485144 140890 splicing regulatory glutamic acid and lysine rich protein 1 "GO:0003723,GO:0005515,GO:0005654,GO:0005681,GO:0006397,GO:0008380,GO:0016607" RNA binding|protein binding|nucleoplasm|spliceosomal complex|mRNA processing|RNA splicing|nuclear speck SREK1IP1 562.9068996 459.7750537 666.0387456 1.448618711 0.534677915 0.178176866 1 3.314259106 5.007909574 285672 SREK1 interacting protein 1 "GO:0003676,GO:0005515,GO:0006397,GO:0008270,GO:0008380" nucleic acid binding|protein binding|mRNA processing|zinc ion binding|RNA splicing SRF 1217.483722 1158.06476 1276.902684 1.102617684 0.140932645 0.680930191 1 13.68133769 15.73509778 6722 serum response factor "GO:0000978,GO:0000981,GO:0001228,GO:0001569,GO:0001666,GO:0001707,GO:0001764,GO:0001829,GO:0001947,GO:0002011,GO:0002042,GO:0003257,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007160,GO:0007507,GO:0007616,GO:0008134,GO:0008285,GO:0008306,GO:0009636,GO:0009725,GO:0010669,GO:0010735,GO:0010736,GO:0021766,GO:0022028,GO:0030036,GO:0030155,GO:0030168,GO:0030220,GO:0030336,GO:0030878,GO:0031175,GO:0031490,GO:0033561,GO:0034097,GO:0035855,GO:0035912,GO:0042803,GO:0042826,GO:0043149,GO:0043589,GO:0045059,GO:0045214,GO:0045597,GO:0045773,GO:0045944,GO:0045987,GO:0046016,GO:0046716,GO:0048538,GO:0048589,GO:0048666,GO:0048821,GO:0051091,GO:0051150,GO:0051491,GO:0055003,GO:0060055,GO:0060218,GO:0060261,GO:0060292,GO:0060324,GO:0060347,GO:0060425,GO:0060532,GO:0060534,GO:0060947,GO:0061029,GO:0061145,GO:0061629,GO:0070830,GO:0070878,GO:0071333,GO:0090009,GO:0090136,GO:0090398,GO:1900222,GO:1902894,GO:1902895,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|branching involved in blood vessel morphogenesis|response to hypoxia|mesoderm formation|neuron migration|trophectodermal cell differentiation|heart looping|morphogenesis of an epithelial sheet|cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|cell-matrix adhesion|heart development|long-term memory|transcription factor binding|negative regulation of cell population proliferation|associative learning|response to toxic substance|response to hormone|epithelial structure maintenance|positive regulation of transcription via serum response element binding|serum response element binding|hippocampus development|tangential migration from the subventricular zone to the olfactory bulb|actin cytoskeleton organization|regulation of cell adhesion|platelet activation|platelet formation|negative regulation of cell migration|thyroid gland development|neuron projection development|chromatin DNA binding|regulation of water loss via skin|response to cytokine|megakaryocyte development|dorsal aorta morphogenesis|protein homodimerization activity|histone deacetylase binding|stress fiber assembly|skin morphogenesis|positive thymic T cell selection|sarcomere organization|positive regulation of cell differentiation|positive regulation of axon extension|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle contraction|positive regulation of transcription by glucose|muscle cell cellular homeostasis|thymus development|developmental growth|neuron development|erythrocyte development|positive regulation of DNA-binding transcription factor activity|regulation of smooth muscle cell differentiation|positive regulation of filopodium assembly|cardiac myofibril assembly|angiogenesis involved in wound healing|hematopoietic stem cell differentiation|positive regulation of transcription initiation from RNA polymerase II promoter|long-term synaptic depression|face development|heart trabecula formation|lung morphogenesis|bronchus cartilage development|trachea cartilage development|cardiac vascular smooth muscle cell differentiation|eyelid development in camera-type eye|lung smooth muscle development|RNA polymerase II-specific DNA-binding transcription factor binding|bicellular tight junction assembly|primary miRNA binding|cellular response to glucose stimulus|primitive streak formation|epithelial cell-cell adhesion|cellular senescence|negative regulation of amyloid-beta clearance|negative regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa04010,hsa04022,hsa05166,hsa05203" MAPK signaling pathway|cGMP-PKG signaling pathway|Human T-cell leukemia virus 1 infection|Viral carcinogenesis SRF SRFBP1 263.1450252 308.5466144 217.7434361 0.705706775 -0.502859235 0.308372474 1 4.937376787 3.634431494 153443 serum response factor binding protein 1 "GO:0003723,GO:0005634,GO:0030490,GO:0030686,GO:0048471" RNA binding|nucleus|maturation of SSU-rRNA|90S preribosome|perinuclear region of cytoplasm SRGAP1 1539.365303 1541.718116 1537.01249 0.996947804 -0.004410122 0.991583923 1 7.018659211 7.298649473 57522 SLIT-ROBO Rho GTPase activating protein 1 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0030336,GO:0043547,GO:0051056" GTPase activator activity|protein binding|cytoplasm|cytosol|signal transduction|negative regulation of cell migration|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction hsa04360 Axon guidance SRGAP2 2108.129849 1930.446252 2285.813446 1.184085516 0.243773278 0.448054101 1 10.2035371 12.60229804 23380 SLIT-ROBO Rho GTPase activating protein 2 "GO:0003363,GO:0005096,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0014069,GO:0021816,GO:0030027,GO:0030336,GO:0031267,GO:0034446,GO:0042802,GO:0042803,GO:0043547,GO:0044327,GO:0045211,GO:0045335,GO:0046847,GO:0048812,GO:0051014,GO:0051056,GO:0060548,GO:0060996,GO:2001223" lamellipodium assembly involved in ameboidal cell migration|GTPase activator activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|signal transduction|postsynaptic density|extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration|lamellipodium|negative regulation of cell migration|small GTPase binding|substrate adhesion-dependent cell spreading|identical protein binding|protein homodimerization activity|positive regulation of GTPase activity|dendritic spine head|postsynaptic membrane|phagocytic vesicle|filopodium assembly|neuron projection morphogenesis|actin filament severing|regulation of small GTPase mediated signal transduction|negative regulation of cell death|dendritic spine development|negative regulation of neuron migration hsa04360 Axon guidance SRGAP2B 259.4645106 225.320225 293.6087961 1.30307342 0.381918373 0.442337555 1 1.068008845 1.451642469 647135 SLIT-ROBO Rho GTPase activating protein 2B "GO:0005737,GO:0007399,GO:0030336" cytoplasm|nervous system development|negative regulation of cell migration SRGAP2C 352.7150125 302.4568786 402.9731464 1.332332557 0.413954231 0.358276359 1 2.160255803 3.002159421 653464 SLIT-ROBO Rho GTPase activating protein 2C "GO:0005737,GO:0021816,GO:0030336,GO:0042803,GO:0046982,GO:0051490,GO:0061000,GO:2001224" cytoplasm|extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration|negative regulation of cell migration|protein homodimerization activity|protein heterodimerization activity|negative regulation of filopodium assembly|negative regulation of dendritic spine development|positive regulation of neuron migration SRGAP3 6.971079795 5.074779842 8.867379749 1.747342747 0.805162625 0.671092798 1 0.01814214 0.033066067 9901 SLIT-ROBO Rho GTPase activating protein 3 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0030336,GO:0043547,GO:0051056" GTPase activator activity|protein binding|cytoplasm|cytosol|signal transduction|negative regulation of cell migration|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction hsa04360 Axon guidance SRGN 4244.178906 4186.69337 4301.664443 1.027461068 0.03908373 0.903217292 1 76.13689386 81.59742612 5552 serglycin "GO:0001818,GO:0002576,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0006915,GO:0016485,GO:0030141,GO:0030502,GO:0031093,GO:0031214,GO:0033363,GO:0033364,GO:0033371,GO:0033373,GO:0033382,GO:0042629,GO:0050804,GO:0098685,GO:0098978,GO:0099091,GO:0099175,GO:0140507" "negative regulation of cytokine production|platelet degranulation|protein binding|extracellular region|extracellular space|Golgi apparatus|apoptotic process|protein processing|secretory granule|negative regulation of bone mineralization|platelet alpha granule lumen|biomineral tissue development|secretory granule organization|mast cell secretory granule organization|T cell secretory granule organization|maintenance of protease location in mast cell secretory granule|maintenance of granzyme B location in T cell secretory granule|mast cell granule|modulation of chemical synaptic transmission|Schaffer collateral - CA1 synapse|glutamatergic synapse|postsynaptic specialization, intracellular component|regulation of postsynapse organization|granzyme-mediated programmed cell death signaling pathway" SRI 1750.676066 1708.170895 1793.181238 1.049766884 0.070068993 0.831172689 1 36.78266571 40.27652549 6717 sorcin "GO:0001508,GO:0002020,GO:0005102,GO:0005246,GO:0005509,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005789,GO:0005790,GO:0005829,GO:0006816,GO:0006880,GO:0006942,GO:0007165,GO:0007507,GO:0007517,GO:0008016,GO:0010459,GO:0010649,GO:0010880,GO:0016020,GO:0016529,GO:0030018,GO:0030315,GO:0033017,GO:0035774,GO:0042584,GO:0042994,GO:0043679,GO:0044325,GO:0044326,GO:0046982,GO:0051281,GO:0051924,GO:0055118,GO:0060315,GO:0070062,GO:0070491,GO:0086004,GO:1901077,GO:1901841,GO:1901844,GO:2000678" action potential|protease binding|signaling receptor binding|calcium channel regulator activity|calcium ion binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum membrane|smooth endoplasmic reticulum|cytosol|calcium ion transport|intracellular sequestering of iron ion|regulation of striated muscle contraction|signal transduction|heart development|muscle organ development|regulation of heart contraction|negative regulation of heart rate|regulation of cell communication by electrical coupling|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|membrane|sarcoplasmic reticulum|Z disc|T-tubule|sarcoplasmic reticulum membrane|positive regulation of insulin secretion involved in cellular response to glucose stimulus|chromaffin granule membrane|cytoplasmic sequestering of transcription factor|axon terminus|ion channel binding|dendritic spine neck|protein heterodimerization activity|positive regulation of release of sequestered calcium ion into cytosol|regulation of calcium ion transport|negative regulation of cardiac muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|extracellular exosome|repressing transcription factor binding|regulation of cardiac muscle cell contraction|regulation of relaxation of muscle|regulation of high voltage-gated calcium channel activity|regulation of cell communication by electrical coupling involved in cardiac conduction|negative regulation of transcription regulatory region DNA binding SRM 1520.884049 1726.440102 1315.327996 0.76187294 -0.39237768 0.235929372 1 58.92055301 46.823653 6723 spermidine synthase "GO:0004766,GO:0005515,GO:0005829,GO:0006595,GO:0006596,GO:0008295,GO:0042802,GO:0042803,GO:1990830" spermidine synthase activity|protein binding|cytosol|polyamine metabolic process|polyamine biosynthetic process|spermidine biosynthetic process|identical protein binding|protein homodimerization activity|cellular response to leukemia inhibitory factor "hsa00270,hsa00330,hsa00480" Cysteine and methionine metabolism|Arginine and proline metabolism|Glutathione metabolism SRP14 2931.697832 3505.657915 2357.737749 0.672552145 -0.572281967 0.072657229 1 153.1917223 107.467511 6727 signal recognition particle 14 "GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005786,GO:0005829,GO:0006613,GO:0006614,GO:0008312,GO:0030942,GO:0034774,GO:0043312,GO:0045047,GO:1904813" "RNA binding|protein binding|extracellular region|nucleus|cytoplasm|signal recognition particle, endoplasmic reticulum targeting|cytosol|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|endoplasmic reticulum signal peptide binding|secretory granule lumen|neutrophil degranulation|protein targeting to ER|ficolin-1-rich granule lumen" hsa03060 Protein export SRP19 580.2865983 603.8988012 556.6743953 0.921800796 -0.117473082 0.768775645 1 3.193624711 3.07069646 6728 signal recognition particle 19 "GO:0003723,GO:0005515,GO:0005730,GO:0005786,GO:0005829,GO:0006613,GO:0006614,GO:0006617,GO:0008312,GO:0043022,GO:0048500" "RNA binding|protein binding|nucleolus|signal recognition particle, endoplasmic reticulum targeting|cytosol|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|7S RNA binding|ribosome binding|signal recognition particle" hsa03060 Protein export SRP54 1866.525545 1814.741271 1918.309819 1.057070696 0.080071866 0.806037992 1 38.34386457 42.27813735 6729 signal recognition particle 54 "GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005730,GO:0005737,GO:0005783,GO:0005786,GO:0005829,GO:0006614,GO:0006616,GO:0006617,GO:0008312,GO:0016607,GO:0019003,GO:0030593,GO:0030851,GO:0030942,GO:0031017,GO:0043021,GO:0045047" "RNA binding|GTPase activity|protein binding|GTP binding|nucleus|nucleolus|cytoplasm|endoplasmic reticulum|signal recognition particle, endoplasmic reticulum targeting|cytosol|SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|7S RNA binding|nuclear speck|GDP binding|neutrophil chemotaxis|granulocyte differentiation|endoplasmic reticulum signal peptide binding|exocrine pancreas development|ribonucleoprotein complex binding|protein targeting to ER" hsa03060 Protein export SRP68 1455.937754 1462.55155 1449.323957 0.99095581 -0.01310737 0.970841813 1 24.37416139 25.19416101 6730 signal recognition particle 68 "GO:0003723,GO:0005047,GO:0005515,GO:0005730,GO:0005783,GO:0005786,GO:0005829,GO:0005840,GO:0005925,GO:0006614,GO:0008312,GO:0019904,GO:0030942,GO:0042493,GO:0043022,GO:0048500" "RNA binding|signal recognition particle binding|protein binding|nucleolus|endoplasmic reticulum|signal recognition particle, endoplasmic reticulum targeting|cytosol|ribosome|focal adhesion|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|protein domain specific binding|endoplasmic reticulum signal peptide binding|response to drug|ribosome binding|signal recognition particle" hsa03060 Protein export SRP72 1975.127072 2200.424539 1749.829604 0.795223636 -0.330567456 0.305533987 1 26.06871118 21.62343924 6731 signal recognition particle 72 "GO:0003723,GO:0005047,GO:0005515,GO:0005783,GO:0005786,GO:0005829,GO:0006614,GO:0008312,GO:0030911,GO:0043022,GO:0048500" "RNA binding|signal recognition particle binding|protein binding|endoplasmic reticulum|signal recognition particle, endoplasmic reticulum targeting|cytosol|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|TPR domain binding|ribosome binding|signal recognition particle" hsa03060 Protein export SRP9 4191.524167 3853.787812 4529.260523 1.175275014 0.232998386 0.465362782 1 121.6079485 149.0793172 6726 signal recognition particle 9 "GO:0003723,GO:0005047,GO:0005515,GO:0005785,GO:0005786,GO:0005829,GO:0006614,GO:0008312,GO:0045900" "RNA binding|signal recognition particle binding|protein binding|signal recognition particle receptor complex|signal recognition particle, endoplasmic reticulum targeting|cytosol|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|negative regulation of translational elongation" hsa03060 Protein export SRPK1 2170.69414 1930.446252 2410.942027 1.24890399 0.320662574 0.31742023 1 22.48626781 29.29289952 6732 SRSF protein kinase 1 "GO:0000165,GO:0000245,GO:0000287,GO:0000785,GO:0003723,GO:0004672,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0006468,GO:0007059,GO:0008380,GO:0010468,GO:0016032,GO:0016363,GO:0016607,GO:0035092,GO:0035556,GO:0045070,GO:0045071,GO:0045087,GO:0048024,GO:0050684,GO:0106310,GO:0106311" "MAPK cascade|spliceosomal complex assembly|magnesium ion binding|chromatin|RNA binding|protein kinase activity|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|protein phosphorylation|chromosome segregation|RNA splicing|regulation of gene expression|viral process|nuclear matrix|nuclear speck|sperm chromatin condensation|intracellular signal transduction|positive regulation of viral genome replication|negative regulation of viral genome replication|innate immune response|regulation of mRNA splicing, via spliceosome|regulation of mRNA processing|protein serine kinase activity|protein threonine kinase activity" hsa05168 Herpes simplex virus 1 infection SRPK2 1068.803313 1097.167402 1040.439224 0.948295786 -0.07659097 0.828220817 1 7.600555099 7.518047446 6733 SRSF protein kinase 2 "GO:0000165,GO:0000245,GO:0000287,GO:0000785,GO:0001525,GO:0003723,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006468,GO:0008284,GO:0008380,GO:0010468,GO:0010628,GO:0016607,GO:0018105,GO:0030154,GO:0035063,GO:0035556,GO:0043525,GO:0045070,GO:0045071,GO:0045087,GO:0045787,GO:0048024,GO:0050684,GO:0062176,GO:0071889,GO:0106310,GO:0106311" "MAPK cascade|spliceosomal complex assembly|magnesium ion binding|chromatin|angiogenesis|RNA binding|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|protein phosphorylation|positive regulation of cell population proliferation|RNA splicing|regulation of gene expression|positive regulation of gene expression|nuclear speck|peptidyl-serine phosphorylation|cell differentiation|nuclear speck organization|intracellular signal transduction|positive regulation of neuron apoptotic process|positive regulation of viral genome replication|negative regulation of viral genome replication|innate immune response|positive regulation of cell cycle|regulation of mRNA splicing, via spliceosome|regulation of mRNA processing|R-loop disassembly|14-3-3 protein binding|protein serine kinase activity|protein threonine kinase activity" SRPRA 4559.526616 4696.201266 4422.851966 0.94179353 -0.086517284 0.787238187 1 49.54093458 48.66714026 6734 SRP receptor subunit alpha "GO:0003723,GO:0003924,GO:0005047,GO:0005525,GO:0005785,GO:0005789,GO:0006605,GO:0006613,GO:0006614,GO:0016020,GO:0036498,GO:0045047,GO:0070062" RNA binding|GTPase activity|signal recognition particle binding|GTP binding|signal recognition particle receptor complex|endoplasmic reticulum membrane|protein targeting|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|membrane|IRE1-mediated unfolded protein response|protein targeting to ER|extracellular exosome hsa03060 Protein export SRPRB 548.5475745 623.1829646 473.9121844 0.760470378 -0.395036043 0.322913667 1 11.12513877 8.824775553 58477 SRP receptor subunit beta "GO:0005525,GO:0005737,GO:0005785,GO:0005789,GO:0005881,GO:0016020,GO:0016021,GO:0036498,GO:0045047" GTP binding|cytoplasm|signal recognition particle receptor complex|endoplasmic reticulum membrane|cytoplasmic microtubule|membrane|integral component of membrane|IRE1-mediated unfolded protein response|protein targeting to ER hsa03060 Protein export SRPX 516.2580192 436.4310664 596.084972 1.365817005 0.449764201 0.267467631 1 11.3819227 16.21526598 8406 sushi repeat containing protein X-linked "GO:0001845,GO:0005201,GO:0005515,GO:0005776,GO:0005783,GO:0006914,GO:0007155,GO:0009986,GO:0016020,GO:0034976,GO:0060244,GO:0062023,GO:2001241" phagolysosome assembly|extracellular matrix structural constituent|protein binding|autophagosome|endoplasmic reticulum|autophagy|cell adhesion|cell surface|membrane|response to endoplasmic reticulum stress|negative regulation of cell proliferation involved in contact inhibition|collagen-containing extracellular matrix|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand SRPX2 42.79689741 29.43372308 56.16007174 1.908017942 0.932074738 0.297689872 1 0.224302473 0.446408491 27286 sushi repeat containing protein X-linked 2 "GO:0001525,GO:0005102,GO:0005201,GO:0005515,GO:0005615,GO:0005737,GO:0009986,GO:0036458,GO:0042325,GO:0042802,GO:0048870,GO:0051965,GO:0060076,GO:0062023,GO:0071625,GO:0090050,GO:0097060,GO:0098609" angiogenesis|signaling receptor binding|extracellular matrix structural constituent|protein binding|extracellular space|cytoplasm|cell surface|hepatocyte growth factor binding|regulation of phosphorylation|identical protein binding|cell motility|positive regulation of synapse assembly|excitatory synapse|collagen-containing extracellular matrix|vocalization behavior|positive regulation of cell migration involved in sprouting angiogenesis|synaptic membrane|cell-cell adhesion SRR 424.4772491 459.7750537 389.1794445 0.846456199 -0.240492678 0.575008599 1 5.001285326 4.415725336 63826 serine racemase "GO:0000287,GO:0003941,GO:0005509,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006563,GO:0006564,GO:0007420,GO:0007568,GO:0008721,GO:0009069,GO:0016594,GO:0018114,GO:0030165,GO:0030170,GO:0030378,GO:0032496,GO:0042493,GO:0042802,GO:0042803,GO:0042866,GO:0043025,GO:0043278,GO:0045177,GO:0070178,GO:0070179" magnesium ion binding|L-serine ammonia-lyase activity|calcium ion binding|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|L-serine metabolic process|L-serine biosynthetic process|brain development|aging|D-serine ammonia-lyase activity|serine family amino acid metabolic process|glycine binding|threonine racemase activity|PDZ domain binding|pyridoxal phosphate binding|serine racemase activity|response to lipopolysaccharide|response to drug|identical protein binding|protein homodimerization activity|pyruvate biosynthetic process|neuronal cell body|response to morphine|apical part of cell|D-serine metabolic process|D-serine biosynthetic process hsa00260 "Glycine, serine and threonine metabolism" SRRD 366.1118377 410.0422112 322.1814642 0.785727555 -0.347898939 0.435426683 1 15.31503795 12.55179943 402055 SRR1 domain containing "GO:0005634,GO:0005737,GO:0006783,GO:0007017,GO:0007623,GO:0042752,GO:0070453" nucleus|cytoplasm|heme biosynthetic process|microtubule-based process|circadian rhythm|regulation of circadian rhythm|regulation of heme biosynthetic process SRRM1 1315.868387 1249.410797 1382.325976 1.106382288 0.145849966 0.666662467 1 10.84088559 12.51082374 10250 serine and arginine repetitive matrix 1 "GO:0000375,GO:0000398,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006405,GO:0006406,GO:0008380,GO:0016363,GO:0016607,GO:0031124,GO:0071013" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear matrix|nuclear speck|mRNA 3'-end processing|catalytic step 2 spliceosome" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway SRRM2 11135.5144 11252.81682 11018.21197 0.979151456 -0.030396061 0.928940032 1 48.76908048 49.80929225 23524 serine/arginine repetitive matrix 2 "GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0015030,GO:0016607,GO:0047485,GO:0070742,GO:0071005,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|Cajal body|nuclear speck|protein N-terminus binding|C2H2 zinc finger domain binding|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" SRRM3 202.9684292 134.9891438 270.9477146 2.007181518 1.005171092 0.062167617 1 1.849762965 3.872742835 222183 serine/arginine repetitive matrix 3 GO:0003729 mRNA binding SRRM5 10.47888836 9.134603715 11.823173 1.294327961 0.372203218 0.848192439 1 0.191885298 0.259060956 100170229 serine/arginine repetitive matrix 5 SRRT 2467.884481 2680.498712 2255.270249 0.841362183 -0.24920112 0.435065829 1 37.40914951 32.83044371 51593 "serrate, RNA effector molecule" "GO:0000398,GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0006355,GO:0016604,GO:0031053,GO:0032991,GO:0042795,GO:0046685,GO:0050769,GO:0097150" "mRNA splicing, via spliceosome|DNA binding|RNA binding|protein binding|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|nuclear body|primary miRNA processing|protein-containing complex|snRNA transcription by RNA polymerase II|response to arsenic-containing substance|positive regulation of neurogenesis|neuronal stem cell population maintenance" SRSF1 5905.476004 6857.042522 4953.909486 0.722455705 -0.46901896 0.14833427 1 62.65289799 47.21373067 6426 serine and arginine rich splicing factor 1 "GO:0000380,GO:0000395,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006376,GO:0006397,GO:0006405,GO:0006406,GO:0016607,GO:0031124,GO:0035145,GO:0044547,GO:0071013" "alternative mRNA splicing, via spliceosome|mRNA 5'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA splice site selection|mRNA processing|RNA export from nucleus|mRNA export from nucleus|nuclear speck|mRNA 3'-end processing|exon-exon junction complex|DNA topoisomerase binding|catalytic step 2 spliceosome" "hsa03040,hsa04657,hsa05168" Spliceosome|IL-17 signaling pathway|Herpes simplex virus 1 infection SRSF10 2492.271878 2562.76382 2421.779936 0.944987563 -0.081632753 0.798971423 1 11.84800973 11.67850967 10772 serine and arginine rich splicing factor 10 "GO:0000244,GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006376,GO:0016482,GO:0016607,GO:0048024,GO:0048025,GO:0050733,GO:0051082" "spliceosomal tri-snRNP complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|mRNA splice site selection|cytosolic transport|nuclear speck|regulation of mRNA splicing, via spliceosome|negative regulation of mRNA splicing, via spliceosome|RS domain binding|unfolded protein binding" hsa03040 Spliceosome SRSF11 3507.756352 3416.34179 3599.170914 1.053516052 0.075212296 0.813754505 1 25.55015645 28.07699668 9295 serine and arginine rich splicing factor 11 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing" SRSF2 3689.429264 4015.165811 3363.692718 0.837746902 -0.255413649 0.422408701 1 107.7086778 94.11946605 6427 serine and arginine rich splicing factor 2 "GO:0000398,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0006405,GO:0006406,GO:0008380,GO:0016605,GO:0016607,GO:0031124,GO:0045892" "mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|RNA export from nucleus|mRNA export from nucleus|RNA splicing|PML body|nuclear speck|mRNA 3'-end processing|negative regulation of transcription, DNA-templated" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRSF3 3719.701032 4232.366388 3207.035676 0.75774056 -0.400224122 0.208959784 1 50.69877641 40.07134706 6428 serine and arginine rich splicing factor 3 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0006405,GO:0006406,GO:0016607,GO:0031124,GO:0043274,GO:0048024,GO:1990825,GO:1990830" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|cytoplasm|RNA export from nucleus|mRNA export from nucleus|nuclear speck|mRNA 3'-end processing|phospholipase binding|regulation of mRNA splicing, via spliceosome|sequence-specific mRNA binding|cellular response to leukemia inhibitory factor" "hsa03040,hsa05014,hsa05168" Spliceosome|Amyotrophic lateral sclerosis|Herpes simplex virus 1 infection SRSF4 1595.032742 1541.718116 1648.347369 1.069162613 0.096481294 0.770715152 1 33.97849596 37.89342358 6429 serine and arginine rich splicing factor 4 "GO:0000375,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0032868,GO:0048025,GO:1990825" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|response to insulin|negative regulation of mRNA splicing, via spliceosome|sequence-specific mRNA binding" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRSF5 3175.661868 2873.340346 3477.98339 1.2104321 0.275522153 0.386474466 1 60.23367219 76.04938447 6430 serine and arginine rich splicing factor 5 "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006376,GO:0006397,GO:0006405,GO:0006406,GO:0016607,GO:0031124,GO:0032869,GO:0033120,GO:0043422,GO:0051726,GO:0097421" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|nucleolus|cytosol|mRNA splice site selection|mRNA processing|RNA export from nucleus|mRNA export from nucleus|nuclear speck|mRNA 3'-end processing|cellular response to insulin stimulus|positive regulation of RNA splicing|protein kinase B binding|regulation of cell cycle|liver regeneration" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRSF6 3515.493476 4282.099231 2748.887722 0.641948627 -0.639470247 0.045027857 0.96408227 49.82155288 33.36057012 6431 serine and arginine rich splicing factor 6 "GO:0000380,GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0006376,GO:0006405,GO:0006406,GO:0010837,GO:0016607,GO:0031124,GO:0032868,GO:0036002,GO:0045617,GO:0048025,GO:0060501,GO:0060548,GO:0061041,GO:2000675" "alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|mRNA splice site selection|RNA export from nucleus|mRNA export from nucleus|regulation of keratinocyte proliferation|nuclear speck|mRNA 3'-end processing|response to insulin|pre-mRNA binding|negative regulation of keratinocyte differentiation|negative regulation of mRNA splicing, via spliceosome|positive regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of cell death|regulation of wound healing|negative regulation of type B pancreatic cell apoptotic process" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRSF7 2249.756539 2452.13362 2047.379458 0.834937966 -0.260259082 0.416347904 1 41.68912965 36.30721758 6432 serine and arginine rich splicing factor 7 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006397,GO:0006405,GO:0006406,GO:0008270,GO:0008380,GO:0016607,GO:0019904,GO:0031124,GO:0048025,GO:0070062,GO:1990830" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA processing|RNA export from nucleus|mRNA export from nucleus|zinc ion binding|RNA splicing|nuclear speck|protein domain specific binding|mRNA 3'-end processing|negative regulation of mRNA splicing, via spliceosome|extracellular exosome|cellular response to leukemia inhibitory factor" "hsa03040,hsa05014,hsa05168" Spliceosome|Amyotrophic lateral sclerosis|Herpes simplex virus 1 infection SRSF8 601.9421264 669.8709391 534.0133138 0.797188358 -0.327007454 0.403159985 1 7.877083795 6.550015725 10929 serine and arginine rich splicing factor 8 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0016607" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|nuclear speck" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRSF9 3817.537887 4084.182817 3550.892957 0.869425566 -0.201865575 0.526301321 1 179.5568156 162.8359271 8683 serine and arginine rich splicing factor 9 "GO:0000380,GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006376,GO:0006397,GO:0006405,GO:0006406,GO:0009636,GO:0016607,GO:0019904,GO:0031124,GO:0043279,GO:0048025" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|nucleolus|mRNA splice site selection|mRNA processing|RNA export from nucleus|mRNA export from nucleus|response to toxic substance|nuclear speck|protein domain specific binding|mRNA 3'-end processing|response to alkaloid|negative regulation of mRNA splicing, via spliceosome" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRXN1 1875.415936 1715.275587 2035.556285 1.186722589 0.246982726 0.445931645 1 34.36418407 42.53742295 140809 sulfiredoxin 1 "GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006979,GO:0016667,GO:0032542,GO:0034599,GO:0055114,GO:0098869" "protein binding|ATP binding|cytoplasm|cytosol|response to oxidative stress|oxidoreductase activity, acting on a sulfur group of donors|sulfiredoxin activity|cellular response to oxidative stress|oxidation-reduction process|cellular oxidant detoxification" SS18 3487.733859 3462.014808 3513.452909 1.014857851 0.021277667 0.947602832 1 42.58898149 45.08358047 6760 SS18 subunit of BAF chromatin remodeling complex "GO:0000226,GO:0000902,GO:0005515,GO:0005634,GO:0015630,GO:0016514,GO:0030374,GO:0035556,GO:0042493,GO:0045944,GO:0048013,GO:0071564,GO:0097150" microtubule cytoskeleton organization|cell morphogenesis|protein binding|nucleus|microtubule cytoskeleton|SWI/SNF complex|nuclear receptor coactivator activity|intracellular signal transduction|response to drug|positive regulation of transcription by RNA polymerase II|ephrin receptor signaling pathway|npBAF complex|neuronal stem cell population maintenance hsa05202 Transcriptional misregulation in cancer SS18L1 774.2255819 896.2061201 652.2450438 0.727784635 -0.458416502 0.215249787 1 6.832707866 5.186945262 26039 SS18L1 subunit of BAF chromatin remodeling complex "GO:0000776,GO:0000777,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006325,GO:0016358,GO:0016604,GO:0045893,GO:0045944,GO:0050775,GO:0071565" "kinetochore|condensed chromosome kinetochore|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytosol|chromatin organization|dendrite development|nuclear body|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of dendrite morphogenesis|nBAF complex" SS18L2 423.7052688 406.9973433 440.4131942 1.082103364 0.113838313 0.793976884 1 7.189738276 8.115172542 51188 SS18 like 2 "GO:0003713,GO:0005515,GO:0005634,GO:0045944,GO:0050775" transcription coactivator activity|protein binding|nucleus|positive regulation of transcription by RNA polymerase II|positive regulation of dendrite morphogenesis SSB 1171.170851 1225.051854 1117.289848 0.912034739 -0.132839317 0.700236807 1 33.26785773 31.64842823 6741 small RNA binding exonuclease protection factor La "GO:0000049,GO:0000781,GO:0001682,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0006400,GO:0006409,GO:0008033,GO:0008266,GO:0008334,GO:0042780,GO:0071045,GO:0075522,GO:1903608,GO:1990825,GO:1990904" "tRNA binding|chromosome, telomeric region|tRNA 5'-leader removal|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|tRNA modification|tRNA export from nucleus|tRNA processing|poly(U) RNA binding|histone mRNA metabolic process|tRNA 3'-end processing|nuclear histone mRNA catabolic process|IRES-dependent viral translational initiation|protein localization to cytoplasmic stress granule|sequence-specific mRNA binding|ribonucleoprotein complex" hsa05322 Systemic lupus erythematosus SSBP1 1350.834387 1383.384985 1318.283789 0.952940652 -0.069541727 0.83793424 1 54.35497998 54.02827777 6742 single stranded DNA binding protein 1 "GO:0003682,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0006264,GO:0006268,GO:0007005,GO:0009295,GO:0042645,GO:0051096,GO:0070062,GO:0070584,GO:1905776" chromatin binding|single-stranded DNA binding|RNA binding|protein binding|nucleus|mitochondrion|mitochondrial matrix|mitochondrial DNA replication|DNA unwinding involved in DNA replication|mitochondrion organization|nucleoid|mitochondrial nucleoid|positive regulation of helicase activity|extracellular exosome|mitochondrion morphogenesis|positive regulation of DNA helicase activity "hsa03030,hsa03430,hsa03440" DNA replication|Mismatch repair|Homologous recombination SSBP2 225.5646844 197.9164138 253.2129551 1.279393407 0.355459954 0.495296806 1 0.984169676 1.313378849 23635 single stranded DNA binding protein 2 "GO:0003697,GO:0005634,GO:0005737,GO:0006355,GO:0045944" "single-stranded DNA binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II" SSBP3 498.5893238 541.9864871 455.1921604 0.839858873 -0.251781172 0.539666635 1 6.806274128 5.962545161 23648 single stranded DNA binding protein 3 "GO:0003697,GO:0005515,GO:0005634,GO:0045944" single-stranded DNA binding|protein binding|nucleus|positive regulation of transcription by RNA polymerase II SSBP4 593.1638214 675.9606749 510.3669678 0.755024644 -0.405404361 0.301298913 1 9.533562668 7.508138624 170463 single stranded DNA binding protein 4 "GO:0003697,GO:0005515,GO:0005634,GO:0045944" single-stranded DNA binding|protein binding|nucleus|positive regulation of transcription by RNA polymerase II SSC4D 11.04574944 14.20938356 7.882115332 0.554711983 -0.850189203 0.555975575 1 0.249360759 0.144281812 136853 scavenger receptor cysteine rich family member with 4 domains "GO:0005044,GO:0005576,GO:0006897,GO:0016020" scavenger receptor activity|extracellular region|endocytosis|membrane SSC5D 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.039518692 0.030011338 284297 scavenger receptor cysteine rich family member with 5 domains "GO:0001968,GO:0005044,GO:0005515,GO:0005615,GO:0005737,GO:0006897,GO:0006952,GO:0007275,GO:0016020,GO:0031012,GO:0032717,GO:0042494,GO:0043236,GO:0045087,GO:0050829,GO:0050830,GO:0050840,GO:0062023" fibronectin binding|scavenger receptor activity|protein binding|extracellular space|cytoplasm|endocytosis|defense response|multicellular organism development|membrane|extracellular matrix|negative regulation of interleukin-8 production|detection of bacterial lipoprotein|laminin binding|innate immune response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|extracellular matrix binding|collagen-containing extracellular matrix SSH1 3536.598719 3771.576378 3301.62106 0.875395519 -0.191993096 0.546399956 1 12.02196729 10.97730651 54434 slingshot protein phosphatase 1 "GO:0000902,GO:0003779,GO:0004721,GO:0004725,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006470,GO:0008138,GO:0030027,GO:0030036,GO:0030426,GO:0030496,GO:0030837,GO:0031915,GO:0032154,GO:0032268,GO:0035335,GO:0045202,GO:0071318,GO:0098976,GO:0106306,GO:0106307,GO:1901216,GO:1904719,GO:1904754,GO:2000463" cell morphogenesis|actin binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|lamellipodium|actin cytoskeleton organization|growth cone|midbody|negative regulation of actin filament polymerization|positive regulation of synaptic plasticity|cleavage furrow|regulation of cellular protein metabolic process|peptidyl-tyrosine dephosphorylation|synapse|cellular response to ATP|excitatory chemical synaptic transmission|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of neuron death|positive regulation of AMPA glutamate receptor clustering|positive regulation of vascular associated smooth muscle cell migration|positive regulation of excitatory postsynaptic potential "hsa04360,hsa04810" Axon guidance|Regulation of actin cytoskeleton SSH2 1103.542667 1080.928106 1126.157228 1.041842858 0.059137692 0.866873861 1 3.939353479 4.280979033 85464 slingshot protein phosphatase 2 "GO:0003779,GO:0004721,GO:0004725,GO:0005615,GO:0005737,GO:0005856,GO:0006470,GO:0008138,GO:0030036,GO:0030837,GO:0035335,GO:0106306,GO:0106307" actin binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|extracellular space|cytoplasm|cytoskeleton|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|actin cytoskeleton organization|negative regulation of actin filament polymerization|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity "hsa04360,hsa04810" Axon guidance|Regulation of actin cytoskeleton SSH3 1243.056059 1155.019892 1331.092227 1.152440954 0.204692836 0.548126134 1 20.15771291 24.23125281 54961 slingshot protein phosphatase 3 "GO:0003779,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0008138,GO:0030036,GO:0030837,GO:0035335,GO:0106306,GO:0106307" actin binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|cytoskeleton|protein tyrosine/serine/threonine phosphatase activity|actin cytoskeleton organization|negative regulation of actin filament polymerization|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity "hsa04360,hsa04810" Axon guidance|Regulation of actin cytoskeleton SSNA1 1231.435284 1236.216369 1226.654199 0.99226497 -0.011202672 0.976407536 1 72.5492445 75.08902818 8636 SS nuclear autoantigen 1 "GO:0000086,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0010389,GO:0036064,GO:0042073,GO:0042802,GO:0060830,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|nucleus|centrosome|cytosol|regulation of G2/M transition of mitotic cell cycle|ciliary basal body|intraciliary transport|identical protein binding|ciliary receptor clustering involved in smoothened signaling pathway|ciliary basal body-plasma membrane docking SSPN 137.8222115 126.869496 148.7749269 1.172661132 0.229786173 0.713692981 1 1.217179846 1.488823493 8082 sarcospan "GO:0005887,GO:0006936,GO:0007155,GO:0016010,GO:0030133,GO:0042383,GO:0045211" integral component of plasma membrane|muscle contraction|cell adhesion|dystrophin-associated glycoprotein complex|transport vesicle|sarcolemma|postsynaptic membrane SSR1 2540.441462 3161.587841 1919.295083 0.607066822 -0.720072767 0.024469784 0.692408035 16.57419219 10.49505692 6745 signal sequence receptor subunit 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006613,GO:0008284,GO:0016021,GO:0036498" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|positive regulation of cell population proliferation|integral component of membrane|IRE1-mediated unfolded protein response hsa04141 Protein processing in endoplasmic reticulum SSR2 4573.189181 5024.032043 4122.346319 0.820525483 -0.285379955 0.372513693 1 229.6475625 196.5485496 6746 signal sequence receptor subunit 2 "GO:0005515,GO:0005783,GO:0005789,GO:0006613,GO:0016021" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|integral component of membrane hsa04141 Protein processing in endoplasmic reticulum SSR3 3760.045901 3757.366995 3762.724807 1.001425949 0.002055744 0.995802296 1 42.12915278 44.00656757 6747 signal sequence receptor subunit 3 "GO:0005515,GO:0005783,GO:0005789,GO:0006614,GO:0016021" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|SRP-dependent cotranslational protein targeting to membrane|integral component of membrane hsa04141 Protein processing in endoplasmic reticulum SSR4 3356.337393 3437.655865 3275.018921 0.95268958 -0.069921886 0.82670169 1 104.6934108 104.0367301 6748 signal sequence receptor subunit 4 "GO:0005783,GO:0005784,GO:0012505,GO:0016021,GO:0070062" endoplasmic reticulum|Sec61 translocon complex|endomembrane system|integral component of membrane|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum SSRP1 6370.858549 6374.938437 6366.77866 0.998720023 -0.0018478 0.996020779 1 86.5598237 90.17290265 6749 structure specific recognition protein 1 "GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006260,GO:0006281,GO:0006366,GO:0006368,GO:0016032,GO:0031491,GO:0035101,GO:0042393,GO:1901796,GO:1902275" DNA binding|RNA binding|protein binding|nucleoplasm|nucleolus|DNA replication|DNA repair|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|viral process|nucleosome binding|FACT complex|histone binding|regulation of signal transduction by p53 class mediator|regulation of chromatin organization SSTR2 2.463161041 0 4.926322083 Inf Inf 0.189235799 1 0 0.033864453 6752 somatostatin receptor 2 "GO:0004930,GO:0004994,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0006937,GO:0007186,GO:0007187,GO:0007193,GO:0007218,GO:0007283,GO:0008285,GO:0021549,GO:0030165,GO:0030432,GO:0030900,GO:0038170,GO:0042277,GO:0042594,GO:0042923,GO:0043005,GO:0071385,GO:0071392" "G protein-coupled receptor activity|somatostatin receptor activity|protein binding|cytosol|plasma membrane|integral component of plasma membrane|regulation of muscle contraction|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|spermatogenesis|negative regulation of cell population proliferation|cerebellum development|PDZ domain binding|peristalsis|forebrain development|somatostatin signaling pathway|peptide binding|response to starvation|neuropeptide binding|neuron projection|cellular response to glucocorticoid stimulus|cellular response to estradiol stimulus" "hsa04024,hsa04080,hsa04935,hsa04971" "cAMP signaling pathway|Neuroactive ligand-receptor interaction|Growth hormone synthesis, secretion and action|Gastric acid secretion" SSU72 1792.964002 1938.5659 1647.362104 0.849783907 -0.234832072 0.470436798 1 76.46536134 67.77806676 29101 "SSU72 homolog, RNA polymerase II CTD phosphatase" "GO:0005515,GO:0005654,GO:0005829,GO:0005847,GO:0006369,GO:0006378,GO:0008420,GO:0070940,GO:0106306,GO:0106307" protein binding|nucleoplasm|cytosol|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|RNA polymerase II CTD heptapeptide repeat phosphatase activity|dephosphorylation of RNA polymerase II C-terminal domain|protein serine phosphatase activity|protein threonine phosphatase activity hsa03015 mRNA surveillance pathway SSUH2 4.030132322 6.08973581 1.970528833 0.32358199 -1.627796782 0.481837554 1 0.026259995 0.008863289 51066 ssu-2 homolog "GO:0005634,GO:0005737,GO:0042476" nucleus|cytoplasm|odontogenesis SSX2IP 475.0078041 479.0592171 470.9563911 0.983085962 -0.024610523 0.95807884 1 4.009031614 4.110994589 117178 SSX family member 2 interacting protein "GO:0005515,GO:0005634,GO:0005737,GO:0005912,GO:0007098,GO:0007155,GO:0019904,GO:0031252,GO:0032991,GO:0034451,GO:0035020,GO:0035735,GO:0036064,GO:0060271,GO:2000145" protein binding|nucleus|cytoplasm|adherens junction|centrosome cycle|cell adhesion|protein domain specific binding|cell leading edge|protein-containing complex|centriolar satellite|regulation of Rac protein signal transduction|intraciliary transport involved in cilium assembly|ciliary basal body|cilium assembly|regulation of cell motility hsa04520 Adherens junction ST13 7094.194801 6890.536069 7297.853533 1.059112594 0.082855971 0.800717664 1 108.6492352 120.0285987 6767 ST13 Hsp70 interacting protein "GO:0005515,GO:0005737,GO:0005829,GO:0006457,GO:0009617,GO:0019904,GO:0030544,GO:0030674,GO:0031072,GO:0032564,GO:0032991,GO:0042802,GO:0044877,GO:0046983,GO:0051082,GO:0051085,GO:0051087,GO:0061084,GO:0065003,GO:0070062" protein binding|cytoplasm|cytosol|protein folding|response to bacterium|protein domain specific binding|Hsp70 protein binding|protein-macromolecule adaptor activity|heat shock protein binding|dATP binding|protein-containing complex|identical protein binding|protein-containing complex binding|protein dimerization activity|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|negative regulation of protein refolding|protein-containing complex assembly|extracellular exosome ST14 3.463271234 1.014955968 5.911586499 5.824475823 2.542128219 0.321345721 1 0.015553386 0.094492582 6768 ST14 transmembrane serine protease matriptase "GO:0001843,GO:0004252,GO:0005615,GO:0005886,GO:0005887,GO:0006508,GO:0008236,GO:0016323,GO:0019897,GO:0030216,GO:0060672,GO:0070268" neural tube closure|serine-type endopeptidase activity|extracellular space|plasma membrane|integral component of plasma membrane|proteolysis|serine-type peptidase activity|basolateral plasma membrane|extrinsic component of plasma membrane|keratinocyte differentiation|epithelial cell morphogenesis involved in placental branching|cornification hsa05206 MicroRNAs in cancer ST18 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.019256739 0.003899728 9705 ST18 C2H2C-type zinc finger transcription factor "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270,GO:0008285,GO:0032993,GO:0033209,GO:0045944,GO:0070102,GO:0070498,GO:2001269" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|negative regulation of cell population proliferation|protein-DNA complex|tumor necrosis factor-mediated signaling pathway|positive regulation of transcription by RNA polymerase II|interleukin-6-mediated signaling pathway|interleukin-1-mediated signaling pathway|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway" ST20-MTHFS 31.62966016 40.59823873 22.66108158 0.558178933 -0.84120042 0.392466239 1 0.906595048 0.527840505 100528021 ST20-MTHFS readthrough hsa00670 One carbon pool by folate ST3GAL1 646.8416808 910.4155036 383.267858 0.420981251 -1.248172111 0.001332565 0.108804729 4.62619981 2.031435656 6482 "ST3 beta-galactoside alpha-2,3-sialyltransferase 1" "GO:0000139,GO:0002319,GO:0003836,GO:0006054,GO:0006464,GO:0006468,GO:0006487,GO:0010706,GO:0016020,GO:0016021,GO:0016266,GO:0018146,GO:0032588,GO:0047288,GO:0070062,GO:0097503,GO:1905403,GO:1990675,GO:1990676,GO:1990743" "Golgi membrane|memory B cell differentiation|beta-galactoside (CMP) alpha-2,3-sialyltransferase activity|N-acetylneuraminate metabolic process|cellular protein modification process|protein phosphorylation|protein N-linked glycosylation|ganglioside biosynthetic process via lactosylceramide|membrane|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|trans-Golgi network membrane|monosialoganglioside sialyltransferase activity|extracellular exosome|sialylation|negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process|Golgi medial cisterna membrane|Golgi trans cisterna membrane|protein sialylation" "hsa00512,hsa00533,hsa00603,hsa00604" Mucin type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series ST3GAL2 786.8086111 914.4753275 659.1418947 0.720786964 -0.472355176 0.200163123 1 5.847847129 4.396619321 6483 "ST3 beta-galactoside alpha-2,3-sialyltransferase 2" "GO:0000139,GO:0003836,GO:0005576,GO:0006486,GO:0009101,GO:0009247,GO:0009312,GO:0010706,GO:0010707,GO:0016021,GO:0016266,GO:0018146,GO:0030259,GO:0032580,GO:0042803,GO:0047288,GO:0097503,GO:1990743" "Golgi membrane|beta-galactoside (CMP) alpha-2,3-sialyltransferase activity|extracellular region|protein glycosylation|glycoprotein biosynthetic process|glycolipid biosynthetic process|oligosaccharide biosynthetic process|ganglioside biosynthetic process via lactosylceramide|globoside biosynthetic process via lactosylceramide|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|lipid glycosylation|Golgi cisterna membrane|protein homodimerization activity|monosialoganglioside sialyltransferase activity|sialylation|protein sialylation" "hsa00512,hsa00533,hsa00603,hsa00604" Mucin type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series ST3GAL3 432.6077833 342.0401613 523.1754052 1.529573028 0.613128988 0.14882258 1 2.611658002 4.166798044 6487 "ST3 beta-galactoside alpha-2,3-sialyltransferase 3" "GO:0000139,GO:0005515,GO:0005576,GO:0006486,GO:0008118,GO:0008373,GO:0016021,GO:0016266,GO:0018146,GO:0032580,GO:0097503" "Golgi membrane|protein binding|extracellular region|protein glycosylation|N-acetyllactosaminide alpha-2,3-sialyltransferase activity|sialyltransferase activity|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|Golgi cisterna membrane|sialylation" "hsa00513,hsa00514,hsa00515,hsa00533,hsa00601" Various types of N-glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series ST3GAL4 603.4012179 533.8668394 672.9355965 1.260493342 0.333988498 0.392928352 1 9.27245269 12.1913307 6484 "ST3 beta-galactoside alpha-2,3-sialyltransferase 4" "GO:0000139,GO:0003836,GO:0004513,GO:0005576,GO:0006486,GO:0008118,GO:0008373,GO:0009101,GO:0009247,GO:0009312,GO:0016020,GO:0016021,GO:0016266,GO:0018146,GO:0030194,GO:0030259,GO:0032580,GO:0047288,GO:0050890,GO:0097503,GO:1903238,GO:1990743" "Golgi membrane|beta-galactoside (CMP) alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity|extracellular region|protein glycosylation|N-acetyllactosaminide alpha-2,3-sialyltransferase activity|sialyltransferase activity|glycoprotein biosynthetic process|glycolipid biosynthetic process|oligosaccharide biosynthetic process|membrane|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|positive regulation of blood coagulation|lipid glycosylation|Golgi cisterna membrane|monosialoganglioside sialyltransferase activity|cognition|sialylation|positive regulation of leukocyte tethering or rolling|protein sialylation" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series ST3GAL5 62.91514587 91.34603715 34.48425458 0.377512322 -1.405404361 0.077696089 1 0.650134139 0.256005934 8869 "ST3 beta-galactoside alpha-2,3-sialyltransferase 5" "GO:0000139,GO:0001574,GO:0004513,GO:0005887,GO:0005975,GO:0006486,GO:0006688,GO:0008373,GO:0016021,GO:0047291,GO:0097503" "Golgi membrane|ganglioside biosynthetic process|neolactotetraosylceramide alpha-2,3-sialyltransferase activity|integral component of plasma membrane|carbohydrate metabolic process|protein glycosylation|glycosphingolipid biosynthetic process|sialyltransferase activity|integral component of membrane|lactosylceramide alpha-2,3-sialyltransferase activity|sialylation" hsa00604 Glycosphingolipid biosynthesis - ganglio series ST3GAL6 95.6812498 108.6002886 82.76221099 0.762080949 -0.391983845 0.574777853 1 1.290828796 1.026090531 10402 "ST3 beta-galactoside alpha-2,3-sialyltransferase 6" "GO:0000139,GO:0006464,GO:0006486,GO:0006664,GO:0008373,GO:0009311,GO:0016021,GO:0018146,GO:0052798,GO:0070062,GO:0071354,GO:0097503" "Golgi membrane|cellular protein modification process|protein glycosylation|glycolipid metabolic process|sialyltransferase activity|oligosaccharide metabolic process|integral component of membrane|keratan sulfate biosynthetic process|beta-galactoside alpha-2,3-sialyltransferase activity|extracellular exosome|cellular response to interleukin-6|sialylation" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series ST6GAL1 118.612277 93.37594909 143.8486048 1.540531649 0.623428322 0.33188917 1 0.989778654 1.590466911 6480 "ST6 beta-galactoside alpha-2,6-sialyltransferase 1" "GO:0000139,GO:0003835,GO:0005515,GO:0005576,GO:0006054,GO:0006959,GO:0008373,GO:0016021,GO:0016266,GO:0018279,GO:0032580,GO:0042803,GO:0097503" "Golgi membrane|beta-galactoside alpha-2,6-sialyltransferase activity|protein binding|extracellular region|N-acetylneuraminate metabolic process|humoral immune response|sialyltransferase activity|integral component of membrane|O-glycan processing|protein N-linked glycosylation via asparagine|Golgi cisterna membrane|protein homodimerization activity|sialylation" "hsa00510,hsa00514" N-Glycan biosynthesis|Other types of O-glycan biosynthesis ST6GALNAC2 5.493183171 5.074779842 5.911586499 1.164895165 0.220200125 1 1 0.114028259 0.138552787 10610 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2" "GO:0000139,GO:0001665,GO:0006486,GO:0006493,GO:0008373,GO:0016021,GO:0016266,GO:1990743" "Golgi membrane|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity|protein glycosylation|protein O-linked glycosylation|sialyltransferase activity|integral component of membrane|O-glycan processing|protein sialylation" ST6GALNAC4 700.2025819 820.0844224 580.3207413 0.707635367 -0.49892194 0.18664771 1 23.07465717 17.03180662 27090 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4" "GO:0000139,GO:0001574,GO:0001665,GO:0006664,GO:0008373,GO:0009311,GO:0016021,GO:0016266,GO:0047290,GO:0097503" "Golgi membrane|ganglioside biosynthetic process|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity|glycolipid metabolic process|sialyltransferase activity|oligosaccharide metabolic process|integral component of membrane|O-glycan processing|(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity|sialylation" hsa00604 Glycosphingolipid biosynthesis - ganglio series ST6GALNAC5 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.046334901 0.00938339 81849 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5" "GO:0000139,GO:0001574,GO:0001665,GO:0006486,GO:0006688,GO:0008373,GO:0009311,GO:0009312,GO:0016021,GO:0097503" "Golgi membrane|ganglioside biosynthetic process|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity|protein glycosylation|glycosphingolipid biosynthetic process|sialyltransferase activity|oligosaccharide metabolic process|oligosaccharide biosynthetic process|integral component of membrane|sialylation" hsa00604 Glycosphingolipid biosynthesis - ganglio series ST6GALNAC6 1679.014783 1961.909887 1396.119678 0.71161254 -0.490836161 0.133968606 1 30.12850654 22.3633637 30815 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6" "GO:0000139,GO:0001574,GO:0001665,GO:0005515,GO:0005737,GO:0005886,GO:0006486,GO:0006677,GO:0006687,GO:0008373,GO:0009100,GO:0009311,GO:0009312,GO:0009988,GO:0016021,GO:0097503" "Golgi membrane|ganglioside biosynthetic process|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity|protein binding|cytoplasm|plasma membrane|protein glycosylation|glycosylceramide metabolic process|glycosphingolipid metabolic process|sialyltransferase activity|glycoprotein metabolic process|oligosaccharide metabolic process|oligosaccharide biosynthetic process|cell-cell recognition|integral component of membrane|sialylation" hsa00604 Glycosphingolipid biosynthesis - ganglio series ST7 418.5859516 393.8029157 443.3689874 1.125865172 0.171034068 0.692896623 1 5.169706695 6.07111163 7982 suppression of tumorigenicity 7 "GO:0016021,GO:0030198,GO:0045595" integral component of membrane|extracellular matrix organization|regulation of cell differentiation ST7L 201.2920943 188.7818101 213.8023784 1.132536966 0.17955814 0.744943409 1 1.513076863 1.787431085 54879 suppression of tumorigenicity 7 like "GO:0016021,GO:0030308" integral component of membrane|negative regulation of cell growth ST8SIA1 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.026477768 0.026810376 6489 "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1" "GO:0000139,GO:0003828,GO:0005515,GO:0005975,GO:0006486,GO:0006491,GO:0006688,GO:0008284,GO:0008373,GO:0009311,GO:0016021,GO:0034605,GO:0097503" "Golgi membrane|alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity|protein binding|carbohydrate metabolic process|protein glycosylation|N-glycan processing|glycosphingolipid biosynthetic process|positive regulation of cell population proliferation|sialyltransferase activity|oligosaccharide metabolic process|integral component of membrane|cellular response to heat|sialylation" "hsa00601,hsa00603,hsa00604" Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series ST8SIA4 31.62966016 40.59823873 22.66108158 0.558178933 -0.84120042 0.392466239 1 0.239701279 0.139559602 7903 "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4" "GO:0000139,GO:0001574,GO:0003828,GO:0006464,GO:0006486,GO:0006491,GO:0007399,GO:0009311,GO:0016021,GO:0033691,GO:0097503" "Golgi membrane|ganglioside biosynthetic process|alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity|cellular protein modification process|protein glycosylation|N-glycan processing|nervous system development|oligosaccharide metabolic process|integral component of membrane|sialic acid binding|sialylation" STAC 179.9456058 177.6172945 182.2739171 1.026217169 0.037336067 0.957396018 1 2.469308089 2.643202796 6769 SH3 and cysteine rich domain "GO:0003009,GO:0005515,GO:0005829,GO:0007165,GO:0030315,GO:0031234,GO:0034605,GO:0035556,GO:0044325,GO:0046872,GO:1901387,GO:1903078,GO:2001259" skeletal muscle contraction|protein binding|cytosol|signal transduction|T-tubule|extrinsic component of cytoplasmic side of plasma membrane|cellular response to heat|intracellular signal transduction|ion channel binding|metal ion binding|positive regulation of voltage-gated calcium channel activity|positive regulation of protein localization to plasma membrane|positive regulation of cation channel activity STAG1 1231.545885 1344.816658 1118.275113 0.831544662 -0.266134343 0.435065024 1 10.26219971 8.901064985 10274 stromal antigen 1 "GO:0000775,GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0007062,GO:0008278,GO:0016363,GO:0016604,GO:0051301,GO:0090307,GO:0097431" "chromosome, centromeric region|chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|sister chromatid cohesion|cohesin complex|nuclear matrix|nuclear body|cell division|mitotic spindle assembly|mitotic spindle pole" hsa04110 Cell cycle other STAG2 3442.187771 3278.307778 3606.067765 1.099978406 0.137475202 0.665987678 1 24.21037092 27.77803575 10735 stromal antigen 2 "GO:0000775,GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0007062,GO:0008278,GO:0016020,GO:0016363,GO:0051301,GO:0051321,GO:0090307,GO:0097431" "chromosome, centromeric region|chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|sister chromatid cohesion|cohesin complex|membrane|nuclear matrix|cell division|meiotic cell cycle|mitotic spindle assembly|mitotic spindle pole" hsa04110 Cell cycle STAG3 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.033472453 10734 stromal antigen 3 "GO:0000775,GO:0000785,GO:0000795,GO:0003682,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0007062,GO:0007130,GO:0008278,GO:0030893" "chromosome, centromeric region|chromatin|synaptonemal complex|chromatin binding|extracellular space|nucleus|nucleoplasm|nucleolus|sister chromatid cohesion|synaptonemal complex assembly|cohesin complex|meiotic cohesin complex" hsa04114 Oocyte meiosis STAM 929.2953639 956.0885222 902.5022056 0.943952557 -0.083213743 0.818119034 1 9.479739775 9.333886444 8027 signal transducing adaptor molecule "GO:0005515,GO:0005829,GO:0007165,GO:0016197,GO:0016236,GO:0016579,GO:0031901,GO:0033565,GO:0036258,GO:0042059,GO:0043231,GO:0043328,GO:0044389,GO:0061024,GO:1903543,GO:1903551" protein binding|cytosol|signal transduction|endosomal transport|macroautophagy|protein deubiquitination|early endosome membrane|ESCRT-0 complex|multivesicular body assembly|negative regulation of epidermal growth factor receptor signaling pathway|intracellular membrane-bounded organelle|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|ubiquitin-like protein ligase binding|membrane organization|positive regulation of exosomal secretion|regulation of extracellular exosome assembly "hsa04144,hsa04630" Endocytosis|JAK-STAT signaling pathway STAM2 573.3424884 634.3474802 512.3374966 0.807660647 -0.308178848 0.436245199 1 5.871246716 4.946239972 10254 signal transducing adaptor molecule 2 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006886,GO:0007165,GO:0016197,GO:0016236,GO:0016579,GO:0030139,GO:0031901,GO:0033565,GO:0036258,GO:0042059,GO:0043231,GO:0061024" protein binding|nucleoplasm|cytoplasm|cytosol|intracellular protein transport|signal transduction|endosomal transport|macroautophagy|protein deubiquitination|endocytic vesicle|early endosome membrane|ESCRT-0 complex|multivesicular body assembly|negative regulation of epidermal growth factor receptor signaling pathway|intracellular membrane-bounded organelle|membrane organization "hsa04144,hsa04630" Endocytosis|JAK-STAT signaling pathway STAMBP 669.6014857 614.0483609 725.1546106 1.180940553 0.239936343 0.530468315 1 12.40007306 15.27454246 10617 STAM binding protein "GO:0000281,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0007259,GO:0008237,GO:0008284,GO:0014067,GO:0016020,GO:0016579,GO:0018215,GO:0019904,GO:0032154,GO:0046580,GO:0046872,GO:0061578,GO:0070062,GO:0070122,GO:0070536" mitotic cytokinesis|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|endosome|early endosome|cytosol|plasma membrane|receptor signaling pathway via JAK-STAT|metallopeptidase activity|positive regulation of cell population proliferation|negative regulation of phosphatidylinositol 3-kinase signaling|membrane|protein deubiquitination|protein phosphopantetheinylation|protein domain specific binding|cleavage furrow|negative regulation of Ras protein signal transduction|metal ion binding|Lys63-specific deubiquitinase activity|extracellular exosome|isopeptidase activity|protein K63-linked deubiquitination hsa04144 Endocytosis STAMBPL1 627.614425 538.9416192 716.2872308 1.329062751 0.410409222 0.289108068 1 6.01354742 8.336661272 57559 STAM binding protein like 1 "GO:0004843,GO:0005515,GO:0005768,GO:0005829,GO:0008237,GO:0016020,GO:0016579,GO:0018215,GO:0046872,GO:0061578,GO:0070122,GO:0070536" thiol-dependent ubiquitin-specific protease activity|protein binding|endosome|cytosol|metallopeptidase activity|membrane|protein deubiquitination|protein phosphopantetheinylation|metal ion binding|Lys63-specific deubiquitinase activity|isopeptidase activity|protein K63-linked deubiquitination STAP2 436.6445966 449.625494 423.6636991 0.942259068 -0.08580432 0.844066818 1 15.04091485 14.78292959 55620 signal transducing adaptor family member 2 "GO:0005515,GO:0005829,GO:0005886,GO:0035591,GO:0042531" protein binding|cytosol|plasma membrane|signaling adaptor activity|positive regulation of tyrosine phosphorylation of STAT protein STARD10 1053.278098 911.4304596 1195.125737 1.311263766 0.390957919 0.263165477 1 19.8114753 27.0970996 10809 StAR related lipid transfer domain containing 10 "GO:0005515,GO:0005829,GO:0005902,GO:0006656,GO:0006869,GO:0008289,GO:0016020,GO:0031514,GO:0046581" protein binding|cytosol|microvillus|phosphatidylcholine biosynthetic process|lipid transport|lipid binding|membrane|motile cilium|intercellular canaliculus STARD13 491.6924729 541.9864871 441.3984586 0.814408604 -0.296175291 0.471570712 1 3.193682788 2.713001669 90627 StAR related lipid transfer domain containing 13 "GO:0005096,GO:0005515,GO:0005811,GO:0005829,GO:0007165,GO:0008289,GO:0030036,GO:0031966,GO:0035023,GO:0043542,GO:0043547,GO:0051056,GO:0090051,GO:0097498" GTPase activator activity|protein binding|lipid droplet|cytosol|signal transduction|lipid binding|actin cytoskeleton organization|mitochondrial membrane|regulation of Rho protein signal transduction|endothelial cell migration|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|negative regulation of cell migration involved in sprouting angiogenesis|endothelial tube lumen extension STARD3 1324.770901 1184.453615 1465.088187 1.236931669 0.306765805 0.362981596 1 18.22247786 23.51089002 10948 StAR related lipid transfer domain containing 3 "GO:0005515,GO:0005654,GO:0005737,GO:0005765,GO:0005768,GO:0005789,GO:0005829,GO:0006629,GO:0006700,GO:0006839,GO:0008202,GO:0008203,GO:0015485,GO:0016021,GO:0030301,GO:0031902,GO:0042803,GO:0043231,GO:0044232,GO:0099044,GO:0120009,GO:0120020,GO:0140284" protein binding|nucleoplasm|cytoplasm|lysosomal membrane|endosome|endoplasmic reticulum membrane|cytosol|lipid metabolic process|C21-steroid hormone biosynthetic process|mitochondrial transport|steroid metabolic process|cholesterol metabolic process|cholesterol binding|integral component of membrane|cholesterol transport|late endosome membrane|protein homodimerization activity|intracellular membrane-bounded organelle|organelle membrane contact site|vesicle tethering to endoplasmic reticulum|intermembrane lipid transfer|cholesterol transfer activity|endoplasmic reticulum-endosome membrane contact site hsa04979 Cholesterol metabolism STARD3NL 909.1825586 827.1891142 991.176003 1.198245946 0.260924059 0.467284872 1 19.43145199 24.28662416 83930 STARD3 N-terminal like "GO:0005515,GO:0005765,GO:0005768,GO:0005789,GO:0005829,GO:0006700,GO:0015485,GO:0016020,GO:0016021,GO:0031902,GO:0042803,GO:0043231,GO:0044232,GO:0099044,GO:0140284" protein binding|lysosomal membrane|endosome|endoplasmic reticulum membrane|cytosol|C21-steroid hormone biosynthetic process|cholesterol binding|membrane|integral component of membrane|late endosome membrane|protein homodimerization activity|intracellular membrane-bounded organelle|organelle membrane contact site|vesicle tethering to endoplasmic reticulum|endoplasmic reticulum-endosome membrane contact site STARD4 571.7242988 523.7172797 619.731318 1.183331813 0.24285467 0.540575239 1 2.623843372 3.238622858 134429 StAR related lipid transfer domain containing 4 "GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0010873,GO:0010879,GO:0015485,GO:0031410,GO:0032367,GO:0070508,GO:0070859,GO:0120009,GO:0120020" protein binding|cytoplasm|endoplasmic reticulum|cytosol|positive regulation of cholesterol esterification|cholesterol transport involved in cholesterol storage|cholesterol binding|cytoplasmic vesicle|intracellular cholesterol transport|cholesterol import|positive regulation of bile acid biosynthetic process|intermembrane lipid transfer|cholesterol transfer activity STARD5 66.30690982 53.79266632 78.82115332 1.465276937 0.551173359 0.482655626 1 0.557480823 0.852050971 80765 StAR related lipid transfer domain containing 5 "GO:0005829,GO:0015485,GO:0015721,GO:0032052,GO:0070508,GO:0120009,GO:0120020" cytosol|cholesterol binding|bile acid and bile salt transport|bile acid binding|cholesterol import|intermembrane lipid transfer|cholesterol transfer activity STARD6 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.16241371 0 147323 StAR related lipid transfer domain containing 6 "GO:0006869,GO:0008289" lipid transport|lipid binding STARD7 2384.377506 2292.785533 2475.969479 1.079895805 0.110892119 0.729233115 1 34.38599312 38.73284125 56910 StAR related lipid transfer domain containing 7 "GO:0005515,GO:0005741,GO:0006656,GO:0008289" protein binding|mitochondrial outer membrane|phosphatidylcholine biosynthetic process|lipid binding STARD8 100.7020897 47.70293051 153.701249 3.222050455 1.687979086 0.01455773 0.533285056 0.463098552 1.556401675 9754 StAR related lipid transfer domain containing 8 "GO:0005096,GO:0005829,GO:0005925,GO:0007165,GO:0008289,GO:0030036,GO:0035023,GO:0043547,GO:0051056" GTPase activator activity|cytosol|focal adhesion|signal transduction|lipid binding|actin cytoskeleton organization|regulation of Rho protein signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction STARD9 511.9255282 477.0293051 546.8217512 1.146306412 0.196992733 0.63002271 1 1.446178106 1.729172953 57519 StAR related lipid transfer domain containing 9 "GO:0003777,GO:0005524,GO:0005634,GO:0005737,GO:0005814,GO:0007018,GO:0008017,GO:0008289,GO:0051225" microtubule motor activity|ATP binding|nucleus|cytoplasm|centriole|microtubule-based movement|microtubule binding|lipid binding|spindle assembly STAT1 1886.88281 1690.916643 2082.848977 1.231786904 0.300752695 0.352966826 1 19.14575515 24.59937158 6772 signal transducer and activator of transcription 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000979,GO:0000981,GO:0001937,GO:0002053,GO:0002230,GO:0003340,GO:0003690,GO:0003700,GO:0005164,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006952,GO:0007221,GO:0007259,GO:0008015,GO:0010742,GO:0016032,GO:0016525,GO:0019221,GO:0019899,GO:0030424,GO:0030425,GO:0032727,GO:0032991,GO:0033209,GO:0034097,GO:0035035,GO:0035257,GO:0035456,GO:0035458,GO:0038113,GO:0038114,GO:0042127,GO:0042393,GO:0042802,GO:0042803,GO:0042981,GO:0043124,GO:0043434,GO:0043542,GO:0044389,GO:0045296,GO:0045648,GO:0045893,GO:0045944,GO:0046725,GO:0048471,GO:0048661,GO:0051591,GO:0051607,GO:0060333,GO:0060334,GO:0060337,GO:0061326,GO:0070102,GO:0070106,GO:0070491,GO:0070757,GO:0071346,GO:0072136,GO:0072162,GO:0072308,GO:1990841" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|negative regulation of endothelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of defense response to virus by host|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|double-stranded DNA binding|DNA-binding transcription factor activity|tumor necrosis factor receptor binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|defense response|positive regulation of transcription of Notch receptor target|receptor signaling pathway via JAK-STAT|blood circulation|macrophage derived foam cell differentiation|viral process|negative regulation of angiogenesis|cytokine-mediated signaling pathway|enzyme binding|axon|dendrite|positive regulation of interferon-alpha production|protein-containing complex|tumor necrosis factor-mediated signaling pathway|response to cytokine|histone acetyltransferase binding|nuclear hormone receptor binding|response to interferon-beta|cellular response to interferon-beta|interleukin-9-mediated signaling pathway|interleukin-21-mediated signaling pathway|regulation of cell population proliferation|histone binding|identical protein binding|protein homodimerization activity|regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|response to peptide hormone|endothelial cell migration|ubiquitin-like protein ligase binding|cadherin binding|positive regulation of erythrocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation by virus of viral protein levels in host cell|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|response to cAMP|defense response to virus|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|renal tubule development|interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|repressing transcription factor binding|interleukin-35-mediated signaling pathway|cellular response to interferon-gamma|metanephric mesenchymal cell proliferation involved in metanephros development|metanephric mesenchymal cell differentiation|negative regulation of metanephric nephron tubule epithelial cell differentiation|promoter-specific chromatin binding" "hsa04062,hsa04217,hsa04380,hsa04620,hsa04621,hsa04625,hsa04630,hsa04658,hsa04659,hsa04917,hsa04919,hsa04933,hsa04935,hsa05140,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200,hsa05212,hsa05235,hsa05321" "Chemokine signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Prolactin signaling pathway|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Leishmaniasis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Pancreatic cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease" STAT STAT2 1381.337252 1144.870332 1617.804172 1.413089436 0.498852778 0.136898247 1 12.20194518 17.9851742 6773 signal transducer and activator of transcription 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001932,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0006952,GO:0007259,GO:0016032,GO:0019221,GO:0042127,GO:0042802,GO:0043434,GO:0044389,GO:0051607,GO:0060337,GO:0090140" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|regulation of protein phosphorylation|protein binding|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|defense response|receptor signaling pathway via JAK-STAT|viral process|cytokine-mediated signaling pathway|regulation of cell population proliferation|identical protein binding|response to peptide hormone|ubiquitin-like protein ligase binding|defense response to virus|type I interferon signaling pathway|regulation of mitochondrial fission" "hsa04062,hsa04217,hsa04380,hsa04621,hsa04625,hsa04630,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200" Chemokine signaling pathway|Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer STAT STAT3 2750.390866 2628.735958 2872.045774 1.092557724 0.127709504 0.688958414 1 26.36882604 30.05045944 6774 signal transducer and activator of transcription 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001103,GO:0001228,GO:0001659,GO:0001754,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006606,GO:0006952,GO:0006954,GO:0007165,GO:0007259,GO:0007399,GO:0008134,GO:0010507,GO:0010628,GO:0016032,GO:0016310,GO:0019221,GO:0019901,GO:0019903,GO:0019953,GO:0030335,GO:0030522,GO:0031490,GO:0032355,GO:0032731,GO:0032733,GO:0032755,GO:0032757,GO:0032760,GO:0032870,GO:0033210,GO:0035019,GO:0035723,GO:0038111,GO:0038113,GO:0038114,GO:0038155,GO:0042127,GO:0042531,GO:0042593,GO:0042755,GO:0042802,GO:0042803,GO:0043434,GO:0044320,GO:0044321,GO:0045648,GO:0045747,GO:0045893,GO:0045944,GO:0046983,GO:0048708,GO:0051092,GO:0051726,GO:0060019,GO:0060259,GO:0060396,GO:0060397,GO:0070102,GO:0070106,GO:0070757,GO:0070878,GO:0071345,GO:0072538,GO:0072540,GO:0090575,GO:0097009,GO:1900017,GO:1902895,GO:1904685,GO:1905618,GO:2000635,GO:2000637" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|temperature homeostasis|eye photoreceptor cell differentiation|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|protein import into nucleus|defense response|inflammatory response|signal transduction|receptor signaling pathway via JAK-STAT|nervous system development|transcription factor binding|negative regulation of autophagy|positive regulation of gene expression|viral process|phosphorylation|cytokine-mediated signaling pathway|protein kinase binding|protein phosphatase binding|sexual reproduction|positive regulation of cell migration|intracellular receptor signaling pathway|chromatin DNA binding|response to estradiol|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|cellular response to hormone stimulus|leptin-mediated signaling pathway|somatic stem cell population maintenance|interleukin-15-mediated signaling pathway|interleukin-7-mediated signaling pathway|interleukin-9-mediated signaling pathway|interleukin-21-mediated signaling pathway|interleukin-23-mediated signaling pathway|regulation of cell population proliferation|positive regulation of tyrosine phosphorylation of STAT protein|glucose homeostasis|eating behavior|identical protein binding|protein homodimerization activity|response to peptide hormone|cellular response to leptin stimulus|response to leptin|positive regulation of erythrocyte differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|astrocyte differentiation|positive regulation of NF-kappaB transcription factor activity|regulation of cell cycle|radial glial cell differentiation|regulation of feeding behavior|growth hormone receptor signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway|primary miRNA binding|cellular response to cytokine stimulus|T-helper 17 type immune response|T-helper 17 cell lineage commitment|RNA polymerase II transcription regulator complex|energy homeostasis|positive regulation of cytokine production involved in inflammatory response|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of metalloendopeptidase activity|positive regulation of miRNA mediated inhibition of translation|negative regulation of primary miRNA processing|positive regulation of gene silencing by miRNA" "hsa01521,hsa04062,hsa04066,hsa04068,hsa04217,hsa04550,hsa04630,hsa04659,hsa04917,hsa04920,hsa04931,hsa04933,hsa04935,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05167,hsa05169,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05212,hsa05221,hsa05223,hsa05235,hsa05321" "EGFR tyrosine kinase inhibitor resistance|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Necroptosis|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|Th17 cell differentiation|Prolactin signaling pathway|Adipocytokine signaling pathway|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Pancreatic cancer|Acute myeloid leukemia|Non-small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease" STAT STAT4 11.97163076 10.14955968 13.79370183 1.359044359 0.442592546 0.785314006 1 0.137997152 0.195622897 6775 signal transducer and activator of transcription 4 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006952,GO:0007259,GO:0019221,GO:0035722,GO:0038114,GO:0038155,GO:0042127,GO:0042802,GO:0043434,GO:0045944,GO:0070757" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|defense response|receptor signaling pathway via JAK-STAT|cytokine-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-21-mediated signaling pathway|interleukin-23-mediated signaling pathway|regulation of cell population proliferation|identical protein binding|response to peptide hormone|positive regulation of transcription by RNA polymerase II|interleukin-35-mediated signaling pathway" "hsa04217,hsa04630,hsa04658,hsa05161,hsa05200,hsa05321" Necroptosis|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Hepatitis B|Pathways in cancer|Inflammatory bowel disease STAT STAT5A 397.2421847 349.1448531 445.3395163 1.275515054 0.351079926 0.420152953 1 4.11135901 5.469994884 6776 signal transducer and activator of transcription 5A "GO:0000785,GO:0000978,GO:0000981,GO:0001938,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006952,GO:0007259,GO:0007595,GO:0019221,GO:0019530,GO:0035723,GO:0038026,GO:0038110,GO:0038111,GO:0038113,GO:0040014,GO:0042127,GO:0043434,GO:0043536,GO:0060397" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|positive regulation of endothelial cell proliferation|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|defense response|receptor signaling pathway via JAK-STAT|lactation|cytokine-mediated signaling pathway|taurine metabolic process|interleukin-15-mediated signaling pathway|reelin-mediated signaling pathway|interleukin-2-mediated signaling pathway|interleukin-7-mediated signaling pathway|interleukin-9-mediated signaling pathway|regulation of multicellular organism growth|regulation of cell population proliferation|response to peptide hormone|positive regulation of blood vessel endothelial cell migration|growth hormone receptor signaling pathway via JAK-STAT" "hsa04012,hsa04217,hsa04630,hsa04658,hsa04659,hsa04917,hsa04933,hsa04935,hsa05161,hsa05162,hsa05166,hsa05200,hsa05203,hsa05220,hsa05221,hsa05223" "ErbB signaling pathway|Necroptosis|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Prolactin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer" STAT STAT5B 2077.46937 1720.350366 2434.588373 1.415170084 0.500975456 0.119509193 1 13.5568192 20.0116258 6777 signal transducer and activator of transcription 5B "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001553,GO:0001779,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006952,GO:0007259,GO:0007565,GO:0007595,GO:0019218,GO:0019221,GO:0019530,GO:0019915,GO:0030856,GO:0032355,GO:0032743,GO:0032819,GO:0032825,GO:0032870,GO:0033077,GO:0035259,GO:0035723,GO:0038110,GO:0038111,GO:0038113,GO:0040014,GO:0040018,GO:0042104,GO:0042127,GO:0042448,GO:0042802,GO:0043029,GO:0043066,GO:0043434,GO:0045579,GO:0045588,GO:0045647,GO:0045648,GO:0045931,GO:0045944,GO:0045954,GO:0046543,GO:0046544,GO:0046983,GO:0048541,GO:0050729,GO:0060397,GO:0070670,GO:0071363,GO:0071364,GO:0097531" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|luteinization|natural killer cell differentiation|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|defense response|receptor signaling pathway via JAK-STAT|female pregnancy|lactation|regulation of steroid metabolic process|cytokine-mediated signaling pathway|taurine metabolic process|lipid storage|regulation of epithelial cell differentiation|response to estradiol|positive regulation of interleukin-2 production|positive regulation of natural killer cell proliferation|positive regulation of natural killer cell differentiation|cellular response to hormone stimulus|T cell differentiation in thymus|glucocorticoid receptor binding|interleukin-15-mediated signaling pathway|interleukin-2-mediated signaling pathway|interleukin-7-mediated signaling pathway|interleukin-9-mediated signaling pathway|regulation of multicellular organism growth|positive regulation of multicellular organism growth|positive regulation of activated T cell proliferation|regulation of cell population proliferation|progesterone metabolic process|identical protein binding|T cell homeostasis|negative regulation of apoptotic process|response to peptide hormone|positive regulation of B cell differentiation|positive regulation of gamma-delta T cell differentiation|negative regulation of erythrocyte differentiation|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|positive regulation of natural killer cell mediated cytotoxicity|development of secondary female sexual characteristics|development of secondary male sexual characteristics|protein dimerization activity|Peyer's patch development|positive regulation of inflammatory response|growth hormone receptor signaling pathway via JAK-STAT|response to interleukin-4|cellular response to growth factor stimulus|cellular response to epidermal growth factor stimulus|mast cell migration" "hsa04012,hsa04062,hsa04217,hsa04630,hsa04658,hsa04659,hsa04917,hsa04933,hsa04935,hsa05161,hsa05162,hsa05166,hsa05200,hsa05203,hsa05220,hsa05221,hsa05223" "ErbB signaling pathway|Chemokine signaling pathway|Necroptosis|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Prolactin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer" STAT STAT6 3222.95852 3008.32949 3437.587549 1.142689842 0.192433869 0.545378349 1 34.65118852 41.30117732 6778 signal transducer and activator of transcription 6 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006952,GO:0007165,GO:0007259,GO:0019221,GO:0019903,GO:0032481,GO:0035771,GO:0042127,GO:0042802,GO:0043434,GO:0045944,GO:0060397,GO:0120162" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|defense response|signal transduction|receptor signaling pathway via JAK-STAT|cytokine-mediated signaling pathway|protein phosphatase binding|positive regulation of type I interferon production|interleukin-4-mediated signaling pathway|regulation of cell population proliferation|identical protein binding|response to peptide hormone|positive regulation of transcription by RNA polymerase II|growth hormone receptor signaling pathway via JAK-STAT|positive regulation of cold-induced thermogenesis" "hsa04217,hsa04630,hsa04658,hsa04659,hsa05161,hsa05200,hsa05321" Necroptosis|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Hepatitis B|Pathways in cancer|Inflammatory bowel disease STAT STAU1 6415.708615 5938.507371 6892.909858 1.160714204 0.21501279 0.5092301 1 71.42352138 86.47339048 6780 staufen double-stranded RNA binding protein 1 "GO:0003723,GO:0003725,GO:0005515,GO:0005737,GO:0005783,GO:0005791,GO:0005829,GO:0005875,GO:0005886,GO:0008157,GO:0010494,GO:0016020,GO:0016032,GO:0030425,GO:0034599,GO:0036464,GO:0043025,GO:0044297,GO:0045070,GO:0046726,GO:0070062,GO:0098978,GO:0099010,GO:1900273" RNA binding|double-stranded RNA binding|protein binding|cytoplasm|endoplasmic reticulum|rough endoplasmic reticulum|cytosol|microtubule associated complex|plasma membrane|protein phosphatase 1 binding|cytoplasmic stress granule|membrane|viral process|dendrite|cellular response to oxidative stress|cytoplasmic ribonucleoprotein granule|neuronal cell body|cell body|positive regulation of viral genome replication|positive regulation by virus of viral protein levels in host cell|extracellular exosome|glutamatergic synapse|modification of postsynaptic structure|positive regulation of long-term synaptic potentiation STAU2 1494.460305 1368.160645 1620.759965 1.184626945 0.244432806 0.461512165 1 12.39801576 15.31968094 27067 staufen double-stranded RNA binding protein 2 "GO:0003723,GO:0003725,GO:0005515,GO:0005730,GO:0005783,GO:0005874,GO:0016020" RNA binding|double-stranded RNA binding|protein binding|nucleolus|endoplasmic reticulum|microtubule|membrane STBD1 35.01870251 36.53841486 33.49899016 0.916815639 -0.125296441 0.92514613 1 0.824662127 0.788631268 8987 starch binding domain 1 "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0005980,GO:0016020,GO:0019899,GO:0030247,GO:0030315,GO:0034045,GO:0043312,GO:0046907,GO:0048471,GO:0061723,GO:0070821,GO:0101003,GO:2001069,GO:2001070" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|glycogen catabolic process|membrane|enzyme binding|polysaccharide binding|T-tubule|phagophore assembly site membrane|neutrophil degranulation|intracellular transport|perinuclear region of cytoplasm|glycophagy|tertiary granule membrane|ficolin-1-rich granule membrane|glycogen binding|starch binding STC1 3421.382419 5425.954607 1416.810231 0.261117229 -1.937230443 3.98E-09 2.84E-06 71.04587881 19.35041789 6781 stanniocalcin 1 "GO:0001503,GO:0001886,GO:0003421,GO:0005179,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0006874,GO:0007165,GO:0007566,GO:0010596,GO:0016324,GO:0030336,GO:0033280,GO:0035988,GO:0042802,GO:0044070,GO:0046697,GO:0051926,GO:0060348,GO:0071320,GO:0071385,GO:0071456,GO:0086004,GO:0090280,GO:1903403" ossification|endothelial cell morphogenesis|growth plate cartilage axis specification|hormone activity|protein binding|extracellular space|nucleus|cytoplasm|cellular calcium ion homeostasis|signal transduction|embryo implantation|negative regulation of endothelial cell migration|apical plasma membrane|negative regulation of cell migration|response to vitamin D|chondrocyte proliferation|identical protein binding|regulation of anion transport|decidualization|negative regulation of calcium ion transport|bone development|cellular response to cAMP|cellular response to glucocorticoid stimulus|cellular response to hypoxia|regulation of cardiac muscle cell contraction|positive regulation of calcium ion import|negative regulation of renal phosphate excretion STC2 17828.03728 17929.19718 17726.87738 0.988715624 -0.016372464 0.963678137 1 213.4580599 220.1404677 8614 stanniocalcin 2 "GO:0005179,GO:0005615,GO:0005783,GO:0005788,GO:0006874,GO:0007165,GO:0007566,GO:0010629,GO:0019899,GO:0020037,GO:0033280,GO:0042803,GO:0043434,GO:0043687,GO:0044267,GO:0046697,GO:0046885,GO:0048471,GO:0071456" hormone activity|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|cellular calcium ion homeostasis|signal transduction|embryo implantation|negative regulation of gene expression|enzyme binding|heme binding|response to vitamin D|protein homodimerization activity|response to peptide hormone|post-translational protein modification|cellular protein metabolic process|decidualization|regulation of hormone biosynthetic process|perinuclear region of cytoplasm|cellular response to hypoxia STEAP1 155.9699311 188.7818101 123.1580521 0.652383045 -0.616208808 0.292841719 1 7.843423052 5.33733221 26872 STEAP family member 1 "GO:0005215,GO:0005768,GO:0005886,GO:0005887,GO:0005911,GO:0006811,GO:0010008,GO:0015267,GO:0016020,GO:0016491,GO:0046872,GO:0055072,GO:0055085,GO:0055114" transporter activity|endosome|plasma membrane|integral component of plasma membrane|cell-cell junction|ion transport|endosome membrane|channel activity|membrane|oxidoreductase activity|metal ion binding|iron ion homeostasis|transmembrane transport|oxidation-reduction process hsa04978 Mineral absorption STEAP2 157.0618375 162.3929549 151.7307201 0.934342997 -0.097975835 0.876836257 1 0.908798926 0.885706985 261729 STEAP2 metalloreductase "GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006893,GO:0006897,GO:0008823,GO:0009725,GO:0010008,GO:0015677,GO:0030140,GO:0030173,GO:0045055,GO:0046872,GO:0052851,GO:0055072,GO:0055114" endosome|early endosome|cytosol|plasma membrane|Golgi to plasma membrane transport|endocytosis|cupric reductase activity|response to hormone|endosome membrane|copper ion import|trans-Golgi network transport vesicle|integral component of Golgi membrane|regulated exocytosis|metal ion binding|ferric-chelate reductase (NADPH) activity|iron ion homeostasis|oxidation-reduction process hsa04978 Mineral absorption STEAP3 312.1328573 390.7580478 233.5076667 0.597576091 -0.742805668 0.112231273 1 4.059593151 2.53041442 55240 STEAP3 metalloreductase "GO:0005515,GO:0005737,GO:0005768,GO:0005771,GO:0005886,GO:0006915,GO:0007049,GO:0008823,GO:0009306,GO:0010008,GO:0015677,GO:0016021,GO:0033572,GO:0042981,GO:0046872,GO:0052851,GO:0055072,GO:0055114" protein binding|cytoplasm|endosome|multivesicular body|plasma membrane|apoptotic process|cell cycle|cupric reductase activity|protein secretion|endosome membrane|copper ion import|integral component of membrane|transferrin transport|regulation of apoptotic process|metal ion binding|ferric-chelate reductase (NADPH) activity|iron ion homeostasis|oxidation-reduction process "hsa04115,hsa04216" p53 signaling pathway|Ferroptosis STEEP1 652.0772887 594.7641975 709.3903799 1.192725425 0.254261961 0.508575021 1 12.5094304 15.56302237 63932 STING1 ER exit protein 1 STIL 1553.953996 1495.030141 1612.87785 1.078826309 0.10946261 0.741429787 1 13.61834578 15.32469415 6491 STIL centriolar assembly protein "GO:0000578,GO:0001701,GO:0001843,GO:0001947,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0007052,GO:0007224,GO:0007368,GO:0021915,GO:0030900,GO:0030903,GO:0033504,GO:0035264,GO:0042802,GO:0043066,GO:0046599,GO:0051298,GO:0071539" embryonic axis specification|in utero embryonic development|neural tube closure|heart looping|protein binding|cytoplasm|centrosome|centriole|cytosol|mitotic spindle organization|smoothened signaling pathway|determination of left/right symmetry|neural tube development|forebrain development|notochord development|floor plate development|multicellular organism growth|identical protein binding|negative regulation of apoptotic process|regulation of centriole replication|centrosome duplication|protein localization to centrosome STIM1 1369.8298 1301.173551 1438.486048 1.105529732 0.144737826 0.667253677 1 11.40727888 13.15432041 6786 stromal interaction molecule 1 "GO:0002020,GO:0002115,GO:0005246,GO:0005509,GO:0005513,GO:0005515,GO:0005783,GO:0005789,GO:0005874,GO:0005886,GO:0005887,GO:0006874,GO:0030176,GO:0032237,GO:0032541,GO:0033017,GO:0042802,GO:0044853,GO:0045762,GO:0045766,GO:0051010,GO:0051924,GO:0070166,GO:1903779,GO:2001256" protease binding|store-operated calcium entry|calcium channel regulator activity|calcium ion binding|detection of calcium ion|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|microtubule|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|integral component of endoplasmic reticulum membrane|activation of store-operated calcium channel activity|cortical endoplasmic reticulum|sarcoplasmic reticulum membrane|identical protein binding|plasma membrane raft|positive regulation of adenylate cyclase activity|positive regulation of angiogenesis|microtubule plus-end binding|regulation of calcium ion transport|enamel mineralization|regulation of cardiac conduction|regulation of store-operated calcium entry "hsa04020,hsa04611" Calcium signaling pathway|Platelet activation STIM2 304.7757873 359.2944128 250.2571618 0.696523945 -0.521755145 0.267857384 1 3.570838794 2.594312124 57620 stromal interaction molecule 2 "GO:0002115,GO:0005246,GO:0005509,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006874,GO:0015279,GO:0016021,GO:0032237,GO:0051928,GO:0070588" store-operated calcium entry|calcium channel regulator activity|calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cellular calcium ion homeostasis|store-operated calcium channel activity|integral component of membrane|activation of store-operated calcium channel activity|positive regulation of calcium ion transport|calcium ion transmembrane transport hsa04020 Calcium signaling pathway STIMATE 709.9109737 574.4650781 845.3568694 1.471554846 0.557341313 0.139153782 1 6.132932044 9.413703934 375346 STIM activating enhancer "GO:0005246,GO:0005515,GO:0005789,GO:0016020,GO:0016021,GO:0032237,GO:0032541,GO:0035584,GO:0070886,GO:0140268" calcium channel regulator activity|protein binding|endoplasmic reticulum membrane|membrane|integral component of membrane|activation of store-operated calcium channel activity|cortical endoplasmic reticulum|calcium-mediated signaling using intracellular calcium source|positive regulation of calcineurin-NFAT signaling cascade|endoplasmic reticulum-plasma membrane contact site STING1 310.0759754 351.1747651 268.9771857 0.765935404 -0.384705368 0.412212781 1 7.212393747 5.762189048 340061 stimulator of interferon response cGAMP interactor 1 "GO:0000045,GO:0000421,GO:0002218,GO:0002230,GO:0005515,GO:0005654,GO:0005741,GO:0005768,GO:0005776,GO:0005777,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0008134,GO:0016032,GO:0016239,GO:0019901,GO:0030176,GO:0030659,GO:0030667,GO:0031625,GO:0032092,GO:0032479,GO:0032481,GO:0032608,GO:0035438,GO:0035458,GO:0042802,GO:0042803,GO:0043312,GO:0045087,GO:0045944,GO:0048471,GO:0050727,GO:0051091,GO:0051259,GO:0051607,GO:0061507,GO:0061709,GO:0071360,GO:0071407,GO:1990701" autophagosome assembly|autophagosome membrane|activation of innate immune response|positive regulation of defense response to virus by host|protein binding|nucleoplasm|mitochondrial outer membrane|endosome|autophagosome|peroxisome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|transcription factor binding|viral process|positive regulation of macroautophagy|protein kinase binding|integral component of endoplasmic reticulum membrane|cytoplasmic vesicle membrane|secretory granule membrane|ubiquitin protein ligase binding|positive regulation of protein binding|regulation of type I interferon production|positive regulation of type I interferon production|interferon-beta production|cyclic-di-GMP binding|cellular response to interferon-beta|identical protein binding|protein homodimerization activity|neutrophil degranulation|innate immune response|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|regulation of inflammatory response|positive regulation of DNA-binding transcription factor activity|protein complex oligomerization|defense response to virus|cyclic-GMP-AMP binding|reticulophagy|cellular response to exogenous dsRNA|cellular response to organic cyclic compound|integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane "hsa04621,hsa04622,hsa04623,hsa05131,hsa05163,hsa05168,hsa05170,hsa05171" NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Shigellosis|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 STIP1 6703.111884 7535.033109 5871.190658 0.779185781 -0.359960744 0.270702265 1 134.2324464 109.0974133 10963 stress induced phosphoprotein 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005794,GO:0005829,GO:0008022,GO:0030544,GO:0032991,GO:0051087,GO:0051879,GO:0098761,GO:0101031" RNA binding|protein binding|nucleus|Golgi apparatus|cytosol|protein C-terminus binding|Hsp70 protein binding|protein-containing complex|chaperone binding|Hsp90 protein binding|cellular response to interleukin-7|chaperone complex hsa05020 Prion disease STK10 1912.753055 2247.112514 1578.393595 0.702409686 -0.509615356 0.115366639 1 19.26668723 14.11605913 6793 serine/threonine kinase 10 "GO:0004674,GO:0005515,GO:0005524,GO:0005886,GO:0006468,GO:0007049,GO:0035579,GO:0042802,GO:0042803,GO:0043312,GO:0046777,GO:0070062,GO:0071593,GO:0106310,GO:0106311,GO:2000401" protein serine/threonine kinase activity|protein binding|ATP binding|plasma membrane|protein phosphorylation|cell cycle|specific granule membrane|identical protein binding|protein homodimerization activity|neutrophil degranulation|protein autophosphorylation|extracellular exosome|lymphocyte aggregation|protein serine kinase activity|protein threonine kinase activity|regulation of lymphocyte migration hsa04914 Progesterone-mediated oocyte maturation STK11 1000.380138 999.7316288 1001.028647 1.001297367 0.001870491 0.999027072 1 15.37591259 16.05905203 6794 serine/threonine kinase 11 "GO:0000287,GO:0001558,GO:0001894,GO:0001944,GO:0002039,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006468,GO:0006470,GO:0006914,GO:0006974,GO:0007050,GO:0007283,GO:0007409,GO:0008285,GO:0010212,GO:0010508,GO:0016020,GO:0030010,GO:0030275,GO:0030295,GO:0030308,GO:0030511,GO:0032147,GO:0042593,GO:0043276,GO:0045059,GO:0046777,GO:0048814,GO:0050772,GO:0050852,GO:0051645,GO:0051896,GO:0060070,GO:0060770,GO:0070062,GO:0071493,GO:0072332,GO:0090090,GO:0097484,GO:0106310,GO:0106311,GO:0120163,GO:1900182,GO:1901610,GO:1901796,GO:1904262" magnesium ion binding|regulation of cell growth|tissue homeostasis|vasculature development|p53 binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|protein phosphorylation|protein dephosphorylation|autophagy|cellular response to DNA damage stimulus|cell cycle arrest|spermatogenesis|axonogenesis|negative regulation of cell population proliferation|response to ionizing radiation|positive regulation of autophagy|membrane|establishment of cell polarity|LRR domain binding|protein kinase activator activity|negative regulation of cell growth|positive regulation of transforming growth factor beta receptor signaling pathway|activation of protein kinase activity|glucose homeostasis|anoikis|positive thymic T cell selection|protein autophosphorylation|regulation of dendrite morphogenesis|positive regulation of axonogenesis|T cell receptor signaling pathway|Golgi localization|regulation of protein kinase B signaling|canonical Wnt signaling pathway|negative regulation of epithelial cell proliferation involved in prostate gland development|extracellular exosome|cellular response to UV-B|intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of canonical Wnt signaling pathway|dendrite extension|protein serine kinase activity|protein threonine kinase activity|negative regulation of cold-induced thermogenesis|positive regulation of protein localization to nucleus|positive regulation of vesicle transport along microtubule|regulation of signal transduction by p53 class mediator|negative regulation of TORC1 signaling "hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04530,hsa04920" FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Tight junction|Adipocytokine signaling pathway STK11IP 415.2535707 435.4161104 395.091031 0.907387259 -0.140209692 0.747760329 1 4.783576993 4.527530401 114790 serine/threonine kinase 11 interacting protein "GO:0005576,GO:0005737,GO:0005765,GO:0008104,GO:0019901,GO:0035578,GO:0043312" extracellular region|cytoplasm|lysosomal membrane|protein localization|protein kinase binding|azurophil granule lumen|neutrophil degranulation STK16 575.2590774 563.3005624 587.2175923 1.042458736 0.059990278 0.88339022 1 9.12058385 9.917391167 8576 serine/threonine kinase 16 "GO:0004674,GO:0004715,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0018108,GO:0046777,GO:0048471,GO:0106310,GO:0106311" protein serine/threonine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|peptidyl-tyrosine phosphorylation|protein autophosphorylation|perinuclear region of cytoplasm|protein serine kinase activity|protein threonine kinase activity STK17A 659.5531249 634.3474802 684.7587695 1.079469519 0.110322507 0.776031864 1 11.6572794 13.1257316 9263 serine/threonine kinase 17a "GO:0004674,GO:0005524,GO:0005634,GO:0005886,GO:0006468,GO:0006915,GO:0016607,GO:0035556,GO:0043065,GO:0106310,GO:0106311,GO:2000271,GO:2000377" protein serine/threonine kinase activity|ATP binding|nucleus|plasma membrane|protein phosphorylation|apoptotic process|nuclear speck|intracellular signal transduction|positive regulation of apoptotic process|protein serine kinase activity|protein threonine kinase activity|positive regulation of fibroblast apoptotic process|regulation of reactive oxygen species metabolic process STK17B 313.0965949 288.247495 337.9456949 1.172415028 0.229483365 0.626164907 1 2.634672216 3.221987845 9262 serine/threonine kinase 17b "GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005793,GO:0005886,GO:0006468,GO:0006915,GO:0015629,GO:0035556,GO:0043065,GO:0046777,GO:0106310,GO:0106311,GO:2000271" protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|endoplasmic reticulum-Golgi intermediate compartment|plasma membrane|protein phosphorylation|apoptotic process|actin cytoskeleton|intracellular signal transduction|positive regulation of apoptotic process|protein autophosphorylation|protein serine kinase activity|protein threonine kinase activity|positive regulation of fibroblast apoptotic process STK19 156.1386778 132.9592319 179.3181238 1.348669974 0.431537357 0.463101337 1 4.156738297 5.847554812 8859 serine/threonine kinase 19 "GO:0004674,GO:0005524,GO:0005634,GO:0006468,GO:0016607,GO:0031267,GO:0046579,GO:0106310,GO:0106311" protein serine/threonine kinase activity|ATP binding|nucleus|protein phosphorylation|nuclear speck|small GTPase binding|positive regulation of Ras protein signal transduction|protein serine kinase activity|protein threonine kinase activity STK24 2188.268317 1885.788189 2490.748445 1.320799684 0.401411681 0.210646367 1 8.680225313 11.95869761 8428 serine/threonine kinase 24 "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0006468,GO:0007165,GO:0008631,GO:0009267,GO:0016020,GO:0030336,GO:0042542,GO:0045296,GO:0046777,GO:0046872,GO:0048679,GO:0070062,GO:0097194,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|protein phosphorylation|signal transduction|intrinsic apoptotic signaling pathway in response to oxidative stress|cellular response to starvation|membrane|negative regulation of cell migration|response to hydrogen peroxide|cadherin binding|protein autophosphorylation|metal ion binding|regulation of axon regeneration|extracellular exosome|execution phase of apoptosis|protein serine kinase activity|protein threonine kinase activity STK25 2459.207621 2356.727759 2561.687483 1.086967926 0.12030937 0.706894199 1 20.32696644 23.04651322 10494 serine/threonine kinase 25 "GO:0000139,GO:0004672,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0006468,GO:0006979,GO:0007163,GO:0007165,GO:0032874,GO:0036481,GO:0042542,GO:0042803,GO:0046777,GO:0046872,GO:0050772,GO:0051645,GO:0051683,GO:0070062,GO:0090168,GO:0106310,GO:0106311" Golgi membrane|protein kinase activity|protein binding|ATP binding|cytoplasm|Golgi apparatus|protein phosphorylation|response to oxidative stress|establishment or maintenance of cell polarity|signal transduction|positive regulation of stress-activated MAPK cascade|intrinsic apoptotic signaling pathway in response to hydrogen peroxide|response to hydrogen peroxide|protein homodimerization activity|protein autophosphorylation|metal ion binding|positive regulation of axonogenesis|Golgi localization|establishment of Golgi localization|extracellular exosome|Golgi reassembly|protein serine kinase activity|protein threonine kinase activity STK26 7.523095107 9.134603715 5.911586499 0.64716398 -0.627796782 0.748279434 1 0.134447967 0.090757914 51765 serine/threonine kinase 26 "GO:0000287,GO:0004672,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005798,GO:0005829,GO:0006468,GO:0006915,GO:0009267,GO:0012506,GO:0016020,GO:0016324,GO:0030033,GO:0030336,GO:0042542,GO:0042802,GO:0042803,GO:0042981,GO:0046777,GO:0048471,GO:0070062,GO:0071944,GO:0106310,GO:0106311,GO:1903205" magnesium ion binding|protein kinase activity|protein binding|ATP binding|cytoplasm|Golgi apparatus|Golgi-associated vesicle|cytosol|protein phosphorylation|apoptotic process|cellular response to starvation|vesicle membrane|membrane|apical plasma membrane|microvillus assembly|negative regulation of cell migration|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|regulation of apoptotic process|protein autophosphorylation|perinuclear region of cytoplasm|extracellular exosome|cell periphery|protein serine kinase activity|protein threonine kinase activity|regulation of hydrogen peroxide-induced cell death STK3 519.5849569 461.8049656 577.3649481 1.25023547 0.322199838 0.426821677 1 2.593280004 3.38187193 6788 serine/threonine kinase 3 "GO:0000287,GO:0001841,GO:0003157,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0006915,GO:0007165,GO:0007417,GO:0008285,GO:0031098,GO:0032092,GO:0032147,GO:0032991,GO:0035329,GO:0035556,GO:0042802,GO:0043065,GO:0043539,GO:0045600,GO:0046330,GO:0046621,GO:0050821,GO:0051091,GO:0051897,GO:0060215,GO:0060706,GO:0060800,GO:0071902,GO:0090090,GO:0097284,GO:0106310,GO:0106311,GO:1902043" magnesium ion binding|neural tube formation|endocardium development|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|apoptotic process|signal transduction|central nervous system development|negative regulation of cell population proliferation|stress-activated protein kinase signaling cascade|positive regulation of protein binding|activation of protein kinase activity|protein-containing complex|hippo signaling|intracellular signal transduction|identical protein binding|positive regulation of apoptotic process|protein serine/threonine kinase activator activity|positive regulation of fat cell differentiation|positive regulation of JNK cascade|negative regulation of organ growth|protein stabilization|positive regulation of DNA-binding transcription factor activity|positive regulation of protein kinase B signaling|primitive hemopoiesis|cell differentiation involved in embryonic placenta development|regulation of cell differentiation involved in embryonic placenta development|positive regulation of protein serine/threonine kinase activity|negative regulation of canonical Wnt signaling pathway|hepatocyte apoptotic process|protein serine kinase activity|protein threonine kinase activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors "hsa04010,hsa04390,hsa04392" MAPK signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species STK31 5.015396738 6.08973581 3.941057666 0.64716398 -0.627796782 0.826813936 1 0.082027563 0.055371983 56164 serine/threonine kinase 31 "GO:0001669,GO:0004518,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0090305,GO:0106310,GO:0106311" acrosomal vesicle|nuclease activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|nucleic acid phosphodiester bond hydrolysis|protein serine kinase activity|protein threonine kinase activity STK32C 235.7115225 251.7090802 219.7139649 0.872888514 -0.196130692 0.706258302 1 2.191538067 1.995371327 282974 serine/threonine kinase 32C "GO:0004674,GO:0005515,GO:0005524,GO:0018105,GO:0035556,GO:0046872,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|peptidyl-serine phosphorylation|intracellular signal transduction|metal ion binding|protein serine kinase activity|protein threonine kinase activity STK35 2352.761454 2084.719559 2620.803348 1.257149115 0.330155783 0.30167841 1 10.27578503 13.47465747 140901 serine/threonine kinase 35 "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006468,GO:0016604,GO:0051321,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|protein phosphorylation|nuclear body|meiotic cell cycle|protein serine kinase activity|protein threonine kinase activity STK36 444.2149506 428.3114187 460.1184825 1.074261536 0.10334527 0.810563847 1 4.192590329 4.697949933 27148 serine/threonine kinase 36 "GO:0003351,GO:0004674,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0007224,GO:0007228,GO:0007420,GO:0008134,GO:0009791,GO:0045880,GO:0046872,GO:0051090,GO:0060271,GO:0106310,GO:0106311" epithelial cilium movement involved in extracellular fluid movement|protein serine/threonine kinase activity|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|cytosol|protein phosphorylation|smoothened signaling pathway|positive regulation of hh target transcription factor activity|brain development|transcription factor binding|post-embryonic development|positive regulation of smoothened signaling pathway|metal ion binding|regulation of DNA-binding transcription factor activity|cilium assembly|protein serine kinase activity|protein threonine kinase activity STK38 685.348149 646.5269519 724.1693462 1.120091504 0.163616596 0.668382636 1 8.868989518 10.36199968 11329 serine/threonine kinase 38 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0018105,GO:0031435,GO:0035556,GO:0043407,GO:0045296,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cellular protein modification process|protein phosphorylation|peptidyl-serine phosphorylation|mitogen-activated protein kinase kinase kinase binding|intracellular signal transduction|negative regulation of MAP kinase activity|cadherin binding|protein serine kinase activity|protein threonine kinase activity STK38L 468.6778143 484.1339969 453.2216316 0.936149154 -0.095189686 0.823027427 1 4.263550517 4.163249053 23012 serine/threonine kinase 38 like "GO:0000287,GO:0003779,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0015629,GO:0016020,GO:0018105,GO:0035556,GO:0051128,GO:0106310,GO:0106311" magnesium ion binding|actin binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|protein phosphorylation|actin cytoskeleton|membrane|peptidyl-serine phosphorylation|intracellular signal transduction|regulation of cellular component organization|protein serine kinase activity|protein threonine kinase activity STK39 1145.710599 1134.720773 1156.700425 1.019370098 0.027677939 0.938596726 1 5.257488252 5.590184356 27347 serine/threonine kinase 39 "GO:0000187,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005856,GO:0006468,GO:0007165,GO:0008217,GO:0010820,GO:0016301,GO:0016323,GO:0016324,GO:0018105,GO:0018107,GO:0019898,GO:0019901,GO:0032414,GO:0035556,GO:0036438,GO:0038146,GO:0043231,GO:0043268,GO:0046777,GO:0050727,GO:0050801,GO:0071476,GO:0090188,GO:0106310,GO:0106311,GO:1901017,GO:1901380,GO:1905408,GO:1990869,GO:2000650" activation of MAPK activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|cytoskeleton|protein phosphorylation|signal transduction|regulation of blood pressure|positive regulation of T cell chemotaxis|kinase activity|basolateral plasma membrane|apical plasma membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|extrinsic component of membrane|protein kinase binding|positive regulation of ion transmembrane transporter activity|intracellular signal transduction|maintenance of lens transparency|chemokine (C-X-C motif) ligand 12 signaling pathway|intracellular membrane-bounded organelle|positive regulation of potassium ion transport|protein autophosphorylation|regulation of inflammatory response|ion homeostasis|cellular hypotonic response|negative regulation of pancreatic juice secretion|protein serine kinase activity|protein threonine kinase activity|negative regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transport|negative regulation of creatine transmembrane transporter activity|cellular response to chemokine|negative regulation of sodium ion transmembrane transporter activity STK4 2587.933085 2366.877318 2808.988852 1.186791064 0.247065969 0.438533356 1 16.22989254 20.09119838 6789 serine/threonine kinase 4 "GO:0000287,GO:0000902,GO:0001569,GO:0001841,GO:0001934,GO:0003157,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006915,GO:0007165,GO:0007417,GO:0008134,GO:0008285,GO:0016604,GO:0018105,GO:0030216,GO:0031098,GO:0032092,GO:0032147,GO:0032991,GO:0033138,GO:0035329,GO:0035556,GO:0042802,GO:0042803,GO:0043065,GO:0043539,GO:0045600,GO:0046621,GO:0046777,GO:0050821,GO:0060215,GO:0060706,GO:0060800,GO:0071902,GO:0090090,GO:0097284,GO:0106310,GO:0106311,GO:1902043,GO:1904237,GO:1905461" "magnesium ion binding|cell morphogenesis|branching involved in blood vessel morphogenesis|neural tube formation|positive regulation of protein phosphorylation|endocardium development|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|apoptotic process|signal transduction|central nervous system development|transcription factor binding|negative regulation of cell population proliferation|nuclear body|peptidyl-serine phosphorylation|keratinocyte differentiation|stress-activated protein kinase signaling cascade|positive regulation of protein binding|activation of protein kinase activity|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|hippo signaling|intracellular signal transduction|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|protein serine/threonine kinase activator activity|positive regulation of fat cell differentiation|negative regulation of organ growth|protein autophosphorylation|protein stabilization|primitive hemopoiesis|cell differentiation involved in embryonic placenta development|regulation of cell differentiation involved in embryonic placenta development|positive regulation of protein serine/threonine kinase activity|negative regulation of canonical Wnt signaling pathway|hepatocyte apoptotic process|protein serine kinase activity|protein threonine kinase activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of substrate-dependent cell migration, cell attachment to substrate|positive regulation of vascular associated smooth muscle cell apoptotic process" "hsa04010,hsa04014,hsa04068,hsa05200,hsa05223" MAPK signaling pathway|Ras signaling pathway|FoxO signaling pathway|Pathways in cancer|Non-small cell lung cancer STK40 551.6869602 568.3753423 534.9985782 0.941276896 -0.08730891 0.830542923 1 7.415302931 7.280517103 83931 serine/threonine kinase 40 "GO:0003016,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005977,GO:0006468,GO:0010468,GO:0035264,GO:0043066,GO:0043408,GO:0048286,GO:0060425,GO:0106310,GO:0106311" respiratory system process|protein binding|ATP binding|nucleoplasm|cytosol|glycogen metabolic process|protein phosphorylation|regulation of gene expression|multicellular organism growth|negative regulation of apoptotic process|regulation of MAPK cascade|lung alveolus development|lung morphogenesis|protein serine kinase activity|protein threonine kinase activity STKLD1 6.508139139 7.104691779 5.911586499 0.832067975 -0.265226703 0.975312627 1 0.127327521 0.11050884 169436 serine/threonine kinase like domain containing 1 "GO:0004674,GO:0005524,GO:0006468" protein serine/threonine kinase activity|ATP binding|protein phosphorylation STMN1 5004.315847 4119.706276 5888.925418 1.429452739 0.515462921 0.109047809 1 60.99052599 90.93856766 3925 stathmin 1 "GO:0000281,GO:0005515,GO:0005737,GO:0005829,GO:0005874,GO:0007019,GO:0007052,GO:0007165,GO:0007409,GO:0007420,GO:0009615,GO:0015631,GO:0016020,GO:0031110,GO:0031115,GO:0031175,GO:0035024,GO:0035556,GO:0043005,GO:0048012,GO:0051272,GO:0051497,GO:0061436,GO:0070062,GO:0070495,GO:1905098" mitotic cytokinesis|protein binding|cytoplasm|cytosol|microtubule|microtubule depolymerization|mitotic spindle organization|signal transduction|axonogenesis|brain development|response to virus|tubulin binding|membrane|regulation of microtubule polymerization or depolymerization|negative regulation of microtubule polymerization|neuron projection development|negative regulation of Rho protein signal transduction|intracellular signal transduction|neuron projection|hepatocyte growth factor receptor signaling pathway|positive regulation of cellular component movement|negative regulation of stress fiber assembly|establishment of skin barrier|extracellular exosome|negative regulation of thrombin-activated receptor signaling pathway|negative regulation of guanyl-nucleotide exchange factor activity "hsa04010,hsa05206" MAPK signaling pathway|MicroRNAs in cancer STMN3 4949.436971 5621.841109 4277.032832 0.760788637 -0.394432397 0.219433385 1 116.5955854 92.52563069 50861 stathmin 3 "GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0007019,GO:0007399,GO:0015631,GO:0019904,GO:0030426,GO:0031110,GO:0031122,GO:0031175,GO:0035021,GO:0043005,GO:0043087,GO:0051493" protein binding|cytoplasm|Golgi apparatus|cytosol|microtubule depolymerization|nervous system development|tubulin binding|protein domain specific binding|growth cone|regulation of microtubule polymerization or depolymerization|cytoplasmic microtubule organization|neuron projection development|negative regulation of Rac protein signal transduction|neuron projection|regulation of GTPase activity|regulation of cytoskeleton organization STMP1 1058.597092 1039.314912 1077.879272 1.037105558 0.052562742 0.882798398 1 21.38871751 23.13788383 647087 short transmembrane mitochondrial protein 1 "GO:0005515,GO:0005741,GO:0005746,GO:0005758,GO:0016021,GO:0032731,GO:0045087,GO:1900227" protein binding|mitochondrial outer membrane|mitochondrial respirasome|mitochondrial intermembrane space|integral component of membrane|positive regulation of interleukin-1 beta production|innate immune response|positive regulation of NLRP3 inflammasome complex assembly STN1 686.0459005 694.2298824 677.8619186 0.976422848 -0.034422041 0.931650767 1 5.520536104 5.622573187 79991 STN1 subunit of CST complex "GO:0000723,GO:0000781,GO:0001650,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0010833,GO:0016233,GO:0032211,GO:0042162,GO:0043047,GO:0043231,GO:0045111,GO:0045740,GO:1990879" "telomere maintenance|chromosome, telomeric region|fibrillar center|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|telomere maintenance via telomere lengthening|telomere capping|negative regulation of telomere maintenance via telomerase|telomeric DNA binding|single-stranded telomeric DNA binding|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|positive regulation of DNA replication|CST complex" STOM 720.2804985 643.4820839 797.078913 1.238696357 0.308822581 0.411274653 1 10.36251112 13.3889278 2040 stomatin "GO:0005515,GO:0005615,GO:0005739,GO:0005783,GO:0005856,GO:0005886,GO:0005887,GO:0016020,GO:0031982,GO:0035577,GO:0035579,GO:0042470,GO:0042802,GO:0042803,GO:0043312,GO:0044829,GO:0045121,GO:0048471,GO:0070062,GO:0070063,GO:0070821,GO:0072562,GO:0090314,GO:1901585" protein binding|extracellular space|mitochondrion|endoplasmic reticulum|cytoskeleton|plasma membrane|integral component of plasma membrane|membrane|vesicle|azurophil granule membrane|specific granule membrane|melanosome|identical protein binding|protein homodimerization activity|neutrophil degranulation|positive regulation by host of viral genome replication|membrane raft|perinuclear region of cytoplasm|extracellular exosome|RNA polymerase binding|tertiary granule membrane|blood microparticle|positive regulation of protein targeting to membrane|regulation of acid-sensing ion channel activity STOML1 176.1205927 219.2304892 133.0106962 0.606716232 -0.720906186 0.199979969 1 1.464615602 0.926883604 9399 stomatin like 1 "GO:0003674,GO:0005515,GO:0005575,GO:0005886,GO:0006869,GO:0008150,GO:0016021,GO:0031902,GO:0045121" molecular_function|protein binding|cellular_component|plasma membrane|lipid transport|biological_process|integral component of membrane|late endosome membrane|membrane raft STOML2 3542.797819 3723.873448 3361.722189 0.902748774 -0.147603539 0.643020754 1 134.5228624 126.6715068 30968 stomatin like 2 "GO:0001772,GO:0005102,GO:0005515,GO:0005743,GO:0005758,GO:0005856,GO:0006851,GO:0006874,GO:0007005,GO:0008180,GO:0010876,GO:0010918,GO:0015629,GO:0019897,GO:0032623,GO:0034982,GO:0035710,GO:0042101,GO:0042776,GO:0045121,GO:0050852,GO:0051020,GO:0051259,GO:0090297,GO:1900210,GO:1901612,GO:1990046" "immunological synapse|signaling receptor binding|protein binding|mitochondrial inner membrane|mitochondrial intermembrane space|cytoskeleton|mitochondrial calcium ion transmembrane transport|cellular calcium ion homeostasis|mitochondrion organization|COP9 signalosome|lipid localization|positive regulation of mitochondrial membrane potential|actin cytoskeleton|extrinsic component of plasma membrane|interleukin-2 production|mitochondrial protein processing|CD4-positive, alpha-beta T cell activation|T cell receptor complex|mitochondrial ATP synthesis coupled proton transport|membrane raft|T cell receptor signaling pathway|GTPase binding|protein complex oligomerization|positive regulation of mitochondrial DNA replication|positive regulation of cardiolipin metabolic process|cardiolipin binding|stress-induced mitochondrial fusion" STON1 42.2448821 25.37389921 59.11586499 2.329790329 1.220200125 0.174722261 1 0.2276122 0.553131389 11037 stonin 1 "GO:0008021,GO:0016020,GO:0016192,GO:0030100,GO:0030136,GO:0031410,GO:0035615,GO:0043231,GO:0048488" synaptic vesicle|membrane|vesicle-mediated transport|regulation of endocytosis|clathrin-coated vesicle|cytoplasmic vesicle|clathrin adaptor activity|intracellular membrane-bounded organelle|synaptic vesicle endocytosis STON2 53.99110462 53.79266632 54.18954291 1.007377894 0.010604978 1 1 0.472004293 0.495968729 85439 stonin 2 "GO:0005515,GO:0005730,GO:0005829,GO:0008021,GO:0016020,GO:0016192,GO:0030100,GO:0030136,GO:0031410,GO:0035615,GO:0043005,GO:0043231,GO:0048488,GO:0061024" protein binding|nucleolus|cytosol|synaptic vesicle|membrane|vesicle-mediated transport|regulation of endocytosis|clathrin-coated vesicle|cytoplasmic vesicle|clathrin adaptor activity|neuron projection|intracellular membrane-bounded organelle|synaptic vesicle endocytosis|membrane organization STOX1 13.46437316 11.16451565 15.76423066 1.411994139 0.4977341 0.73348906 1 0.088391954 0.130185184 219736 storkhead box 1 "GO:0000977,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0007049,GO:0008284,GO:0010468,GO:0010628,GO:0010629,GO:0010800,GO:0010821,GO:0010971,GO:0033138,GO:0051301,GO:0051881,GO:0061418,GO:0071500,GO:1901858,GO:1902882,GO:1904031" RNA polymerase II transcription regulatory region sequence-specific DNA binding|fibrillar center|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|cell cycle|positive regulation of cell population proliferation|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|regulation of mitochondrion organization|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of peptidyl-serine phosphorylation|cell division|regulation of mitochondrial membrane potential|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to nitrosative stress|regulation of mitochondrial DNA metabolic process|regulation of response to oxidative stress|positive regulation of cyclin-dependent protein kinase activity STOX2 218.7569082 204.0061496 233.5076667 1.14461092 0.194857276 0.715362122 1 0.536820896 0.64091912 56977 storkhead box 2 "GO:0001893,GO:0003674,GO:0005575,GO:0006357,GO:0009792" maternal placenta development|molecular_function|cellular_component|regulation of transcription by RNA polymerase II|embryo development ending in birth or egg hatching STPG1 123.3752955 82.21143344 164.5391576 2.001414532 1.001020008 0.114680275 1 1.343135187 2.803965755 90529 sperm tail PG-rich repeat containing 1 "GO:0003674,GO:0005634,GO:0005739,GO:0043065,GO:1902110" molecular_function|nucleus|mitochondrion|positive regulation of apoptotic process|positive regulation of mitochondrial membrane permeability involved in apoptotic process STRA6 179.0385296 317.6812181 40.39584108 0.127158418 -2.975301124 1.01E-06 0.000430109 3.065821834 0.406637998 64220 signaling receptor and transporter of retinol STRA6 "GO:0001523,GO:0001568,GO:0001822,GO:0003184,GO:0003281,GO:0005886,GO:0005887,GO:0007507,GO:0007612,GO:0007631,GO:0016918,GO:0019841,GO:0030324,GO:0030325,GO:0030540,GO:0032991,GO:0034632,GO:0034633,GO:0038023,GO:0042297,GO:0043010,GO:0043583,GO:0043585,GO:0048286,GO:0048520,GO:0048546,GO:0048566,GO:0048589,GO:0048745,GO:0048844,GO:0050890,GO:0050905,GO:0060322,GO:0060323,GO:0060325,GO:0060426,GO:0060539,GO:0060900,GO:0061029,GO:0061038,GO:0061143,GO:0061156,GO:0061205,GO:0071939,GO:0097070" retinoid metabolic process|blood vessel development|kidney development|pulmonary valve morphogenesis|ventricular septum development|plasma membrane|integral component of plasma membrane|heart development|learning|feeding behavior|retinal binding|retinol binding|lung development|adrenal gland development|female genitalia development|protein-containing complex|retinol transmembrane transporter activity|retinol transport|signaling receptor activity|vocal learning|camera-type eye development|ear development|nose morphogenesis|lung alveolus development|positive regulation of behavior|digestive tract morphogenesis|embryonic digestive tract development|developmental growth|smooth muscle tissue development|artery morphogenesis|cognition|neuromuscular process|head development|head morphogenesis|face morphogenesis|lung vasculature development|diaphragm development|embryonic camera-type eye formation|eyelid development in camera-type eye|uterus morphogenesis|alveolar primary septum development|pulmonary artery morphogenesis|paramesonephric duct development|vitamin A import|ductus arteriosus closure STRADA 629.470147 665.8111153 593.1291788 0.890837003 -0.166766609 0.668469546 1 13.01466003 12.09336069 92335 STE20 related adaptor alpha "GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006611,GO:0007050,GO:0019900,GO:0030295,GO:0032147,GO:0043539,GO:0071902" protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|protein export from nucleus|cell cycle arrest|kinase binding|protein kinase activator activity|activation of protein kinase activity|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity "hsa04150,hsa04152" mTOR signaling pathway|AMPK signaling pathway STRADB 458.8345727 552.1360468 365.5330985 0.662034476 -0.595021746 0.154554449 1 12.41729261 8.574789181 55437 STE20 related adaptor beta "GO:0000902,GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0006611,GO:0007050,GO:0007254,GO:0016235,GO:0032147,GO:2001240" cell morphogenesis|protein kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|protein export from nucleus|cell cycle arrest|JNK cascade|aggresome|activation of protein kinase activity|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04150,hsa04152" mTOR signaling pathway|AMPK signaling pathway STRAP 2774.095111 2834.77202 2713.418203 0.957190978 -0.063121295 0.843775858 1 76.40830352 76.28779875 11171 serine/threonine kinase receptor associated protein "GO:0000122,GO:0000387,GO:0003723,GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0010633,GO:0010719,GO:0030277,GO:0030512,GO:0032797,GO:0034719,GO:0050680,GO:0060394" negative regulation of transcription by RNA polymerase II|spliceosomal snRNP assembly|RNA binding|signaling receptor binding|protein binding|nucleus|cytoplasm|cytosol|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|maintenance of gastrointestinal epithelium|negative regulation of transforming growth factor beta receptor signaling pathway|SMN complex|SMN-Sm protein complex|negative regulation of epithelial cell proliferation|negative regulation of pathway-restricted SMAD protein phosphorylation hsa03013 RNA transport STRBP 628.5388225 736.858033 520.2196119 0.705997069 -0.5022659 0.194275313 1 3.826831408 2.818111407 55342 spermatid perinuclear RNA binding protein "GO:0002177,GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0005515,GO:0005634,GO:0005737,GO:0007275,GO:0007286,GO:0007638,GO:0008017" manchette|DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|protein binding|nucleus|cytoplasm|multicellular organism development|spermatid development|mechanosensory behavior|microtubule binding STRC 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.028313507 161497 stereocilin "GO:0007160,GO:0009986,GO:0032426,GO:0050910,GO:0060088,GO:0060091" cell-matrix adhesion|cell surface|stereocilium tip|detection of mechanical stimulus involved in sensory perception of sound|auditory receptor cell stereocilium organization|kinocilium STRIP1 978.3210523 939.8492267 1016.792878 1.081868079 0.113524591 0.750209843 1 14.26859944 16.10169453 85369 striatin interacting protein 1 "GO:0003674,GO:0005515,GO:0005634,GO:0005829,GO:0007010,GO:0019901,GO:0022604,GO:0030866,GO:0031267,GO:0070062" molecular_function|protein binding|nucleus|cytosol|cytoskeleton organization|protein kinase binding|regulation of cell morphogenesis|cortical actin cytoskeleton organization|small GTPase binding|extracellular exosome STRIP2 324.1005287 265.9184637 382.2825936 1.437593269 0.523655559 0.257049731 1 2.429700899 3.643382558 57464 striatin interacting protein 2 "GO:0003674,GO:0005737,GO:0005829,GO:0007010,GO:0008360,GO:0016477" molecular_function|cytoplasm|cytosol|cytoskeleton organization|regulation of cell shape|cell migration STRN 1025.687973 944.9240066 1106.45194 1.170942776 0.227670574 0.517145221 1 3.339175791 4.078410016 6801 striatin "GO:0005515,GO:0005516,GO:0005737,GO:0005923,GO:0007626,GO:0008285,GO:0014069,GO:0016020,GO:0016055,GO:0016358,GO:0030331,GO:0030425,GO:0043025,GO:0043197,GO:0044877,GO:0045211,GO:0051721,GO:0070016,GO:0070830,GO:0090443" protein binding|calmodulin binding|cytoplasm|bicellular tight junction|locomotory behavior|negative regulation of cell population proliferation|postsynaptic density|membrane|Wnt signaling pathway|dendrite development|estrogen receptor binding|dendrite|neuronal cell body|dendritic spine|protein-containing complex binding|postsynaptic membrane|protein phosphatase 2A binding|armadillo repeat domain binding|bicellular tight junction assembly|FAR/SIN/STRIPAK complex STRN3 949.3987666 1016.98588 881.8116528 0.867083477 -0.205757202 0.563869103 1 12.2140733 11.04682215 29966 striatin 3 "GO:0005515,GO:0005516,GO:0005654,GO:0005794,GO:0005886,GO:0030425,GO:0031267,GO:0032355,GO:0032991,GO:0033147,GO:0043025,GO:0044877,GO:0045892,GO:0051721,GO:0070016,GO:0090443" "protein binding|calmodulin binding|nucleoplasm|Golgi apparatus|plasma membrane|dendrite|small GTPase binding|response to estradiol|protein-containing complex|negative regulation of intracellular estrogen receptor signaling pathway|neuronal cell body|protein-containing complex binding|negative regulation of transcription, DNA-templated|protein phosphatase 2A binding|armadillo repeat domain binding|FAR/SIN/STRIPAK complex" STRN4 1630.324112 1529.538644 1731.10958 1.131785448 0.178600493 0.587082872 1 20.39645509 24.07879387 29888 striatin 4 "GO:0005515,GO:0005516,GO:0005737,GO:0008150,GO:0016020,GO:0030425,GO:0043197,GO:0044877,GO:0051721,GO:0070016,GO:0090443" protein binding|calmodulin binding|cytoplasm|biological_process|membrane|dendrite|dendritic spine|protein-containing complex binding|protein phosphatase 2A binding|armadillo repeat domain binding|FAR/SIN/STRIPAK complex STT3A 6993.837878 7371.625198 6616.050557 0.897502298 -0.156012462 0.633928945 1 120.5511175 112.8555027 3703 STT3 oligosaccharyltransferase complex catalytic subunit A "GO:0004579,GO:0005515,GO:0005789,GO:0006487,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0035000,GO:0043686,GO:0043687,GO:0046872" dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|endoplasmic reticulum membrane|protein N-linked glycosylation|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|oligosaccharyltransferase III complex|co-translational protein modification|post-translational protein modification|metal ion binding "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum STT3B 5893.564495 5739.576001 6047.552989 1.053658491 0.07540734 0.816312672 1 44.65273064 49.07539721 201595 STT3 oligosaccharyltransferase complex catalytic subunit B "GO:0004579,GO:0005515,GO:0005783,GO:0006487,GO:0006516,GO:0006986,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0030433,GO:0032991,GO:0034998,GO:0043686,GO:0043687,GO:0046872" dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|endoplasmic reticulum|protein N-linked glycosylation|glycoprotein catabolic process|response to unfolded protein|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|ubiquitin-dependent ERAD pathway|protein-containing complex|oligosaccharyltransferase I complex|co-translational protein modification|post-translational protein modification|metal ion binding "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum STUB1 1074.937586 1112.391741 1037.483431 0.932660134 -0.100576643 0.774550021 1 39.42527461 38.35430083 10273 STIP1 homology and U-box containing protein 1 "GO:0000151,GO:0000209,GO:0001664,GO:0002931,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006281,GO:0006511,GO:0006515,GO:0016567,GO:0019899,GO:0019900,GO:0030018,GO:0030433,GO:0030512,GO:0030544,GO:0030579,GO:0030674,GO:0030911,GO:0030968,GO:0031072,GO:0031371,GO:0031398,GO:0031625,GO:0031647,GO:0031943,GO:0032091,GO:0032436,GO:0034450,GO:0034605,GO:0038128,GO:0042405,GO:0042803,GO:0043161,GO:0045862,GO:0046332,GO:0048156,GO:0051087,GO:0051443,GO:0051604,GO:0051787,GO:0051865,GO:0051879,GO:0061630,GO:0061684,GO:0070534,GO:0071218,GO:0071456,GO:0090035,GO:0101031" ubiquitin ligase complex|protein polyubiquitination|G protein-coupled receptor binding|response to ischemia|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|protein quality control for misfolded or incompletely synthesized proteins|protein ubiquitination|enzyme binding|kinase binding|Z disc|ubiquitin-dependent ERAD pathway|negative regulation of transforming growth factor beta receptor signaling pathway|Hsp70 protein binding|ubiquitin-dependent SMAD protein catabolic process|protein-macromolecule adaptor activity|TPR domain binding|endoplasmic reticulum unfolded protein response|heat shock protein binding|ubiquitin conjugating enzyme complex|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|regulation of protein stability|regulation of glucocorticoid metabolic process|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin-ubiquitin ligase activity|cellular response to heat|ERBB2 signaling pathway|nuclear inclusion body|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of proteolysis|SMAD binding|tau protein binding|chaperone binding|positive regulation of ubiquitin-protein transferase activity|protein maturation|misfolded protein binding|protein autoubiquitination|Hsp90 protein binding|ubiquitin protein ligase activity|chaperone-mediated autophagy|protein K63-linked ubiquitination|cellular response to misfolded protein|cellular response to hypoxia|positive regulation of chaperone-mediated protein complex assembly|chaperone complex "hsa04120,hsa04141" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum STX10 762.882917 861.6976171 664.0682168 0.7706511 -0.375850244 0.311132077 1 30.3913262 24.42999536 8677 syntaxin 10 "GO:0000149,GO:0005484,GO:0005515,GO:0005802,GO:0005829,GO:0006886,GO:0006906,GO:0012505,GO:0016021,GO:0019905,GO:0030285,GO:0031201,GO:0031982,GO:0032588,GO:0032880,GO:0034498,GO:0042147,GO:0048278,GO:0048471" "SNARE binding|SNAP receptor activity|protein binding|trans-Golgi network|cytosol|intracellular protein transport|vesicle fusion|endomembrane system|integral component of membrane|syntaxin binding|integral component of synaptic vesicle membrane|SNARE complex|vesicle|trans-Golgi network membrane|regulation of protein localization|early endosome to Golgi transport|retrograde transport, endosome to Golgi|vesicle docking|perinuclear region of cytoplasm" hsa05132 Salmonella infection STX11 115.9858124 82.21143344 149.7601913 1.821646759 0.865243229 0.181003425 1 0.845253569 1.606079757 8676 syntaxin 11 "GO:0000149,GO:0005484,GO:0005515,GO:0005794,GO:0005886,GO:0006886,GO:0006887,GO:0006906,GO:0008021,GO:0012505,GO:0016021,GO:0031201,GO:0031629,GO:0048278,GO:0048787,GO:0061025" SNARE binding|SNAP receptor activity|protein binding|Golgi apparatus|plasma membrane|intracellular protein transport|exocytosis|vesicle fusion|synaptic vesicle|endomembrane system|integral component of membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|vesicle docking|presynaptic active zone membrane|membrane fusion hsa04130 SNARE interactions in vesicular transport STX12 578.0691344 519.6574558 636.4808131 1.224808392 0.292556073 0.459164647 1 8.674626531 11.08242675 23673 syntaxin 12 "GO:0000045,GO:0000139,GO:0000149,GO:0000407,GO:0005484,GO:0005515,GO:0005654,GO:0005794,GO:0006886,GO:0006906,GO:0008021,GO:0012505,GO:0016021,GO:0030285,GO:0031083,GO:0031201,GO:0031901,GO:0031982,GO:0033344,GO:0043231,GO:0045121,GO:0045335,GO:0048278,GO:0050821,GO:0055038,GO:0098837" autophagosome assembly|Golgi membrane|SNARE binding|phagophore assembly site|SNAP receptor activity|protein binding|nucleoplasm|Golgi apparatus|intracellular protein transport|vesicle fusion|synaptic vesicle|endomembrane system|integral component of membrane|integral component of synaptic vesicle membrane|BLOC-1 complex|SNARE complex|early endosome membrane|vesicle|cholesterol efflux|intracellular membrane-bounded organelle|membrane raft|phagocytic vesicle|vesicle docking|protein stabilization|recycling endosome membrane|postsynaptic recycling endosome hsa04145 Phagosome STX16 4155.233679 4403.893947 3906.573412 0.887072545 -0.172876001 0.588060757 1 51.88222666 48.00579591 8675 syntaxin 16 "GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0005925,GO:0006886,GO:0006906,GO:0012505,GO:0016021,GO:0019905,GO:0030285,GO:0031201,GO:0031985,GO:0032588,GO:0042147,GO:0043231,GO:0048278,GO:0048471,GO:0090161" "Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|focal adhesion|intracellular protein transport|vesicle fusion|endomembrane system|integral component of membrane|syntaxin binding|integral component of synaptic vesicle membrane|SNARE complex|Golgi cisterna|trans-Golgi network membrane|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|vesicle docking|perinuclear region of cytoplasm|Golgi ribbon formation" hsa04130 SNARE interactions in vesicular transport STX17 783.4749925 787.6058315 779.3441535 0.98951039 -0.015213239 0.970909037 1 5.193263489 5.360146334 55014 syntaxin 17 "GO:0000149,GO:0000421,GO:0005484,GO:0005515,GO:0005739,GO:0005765,GO:0005776,GO:0005789,GO:0005791,GO:0005793,GO:0005829,GO:0005886,GO:0006886,GO:0006887,GO:0006888,GO:0006906,GO:0007030,GO:0012505,GO:0012507,GO:0016021,GO:0016240,GO:0019901,GO:0019903,GO:0030134,GO:0030868,GO:0030897,GO:0031201,GO:0033116,GO:0034497,GO:0044233,GO:0048278,GO:0097111,GO:0097352" SNARE binding|autophagosome membrane|SNAP receptor activity|protein binding|mitochondrion|lysosomal membrane|autophagosome|endoplasmic reticulum membrane|rough endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|intracellular protein transport|exocytosis|endoplasmic reticulum to Golgi vesicle-mediated transport|vesicle fusion|Golgi organization|endomembrane system|ER to Golgi transport vesicle membrane|integral component of membrane|autophagosome membrane docking|protein kinase binding|protein phosphatase binding|COPII-coated ER to Golgi transport vesicle|smooth endoplasmic reticulum membrane|HOPS complex|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|protein localization to phagophore assembly site|mitochondria-associated endoplasmic reticulum membrane|vesicle docking|endoplasmic reticulum-Golgi intermediate compartment organization|autophagosome maturation "hsa04130,hsa04140" SNARE interactions in vesicular transport|Autophagy - animal STX18 404.2078213 421.2067269 387.2089157 0.919284738 -0.121416305 0.783201663 1 8.66475824 8.308496278 53407 syntaxin 18 "GO:0000139,GO:0005484,GO:0005515,GO:0005783,GO:0005789,GO:0006886,GO:0006890,GO:0016021,GO:0019904,GO:0031201,GO:0061025,GO:0090158,GO:1902117,GO:1902953,GO:1903358" "Golgi membrane|SNAP receptor activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|integral component of membrane|protein domain specific binding|SNARE complex|membrane fusion|endoplasmic reticulum membrane organization|positive regulation of organelle assembly|positive regulation of ER to Golgi vesicle-mediated transport|regulation of Golgi organization" "hsa04130,hsa04145" SNARE interactions in vesicular transport|Phagosome STX1A 712.1769343 796.7404352 627.6134333 0.787726348 -0.344233563 0.360661184 1 14.59916509 11.99552669 6804 syntaxin 1A "GO:0000149,GO:0001956,GO:0005484,GO:0005515,GO:0005576,GO:0005829,GO:0005886,GO:0006886,GO:0006887,GO:0006906,GO:0007269,GO:0008021,GO:0008076,GO:0009629,GO:0010701,GO:0010807,GO:0012505,GO:0014047,GO:0014069,GO:0016021,GO:0016079,GO:0016081,GO:0016925,GO:0017156,GO:0019221,GO:0019855,GO:0019869,GO:0019900,GO:0019904,GO:0030073,GO:0030141,GO:0030285,GO:0030424,GO:0031201,GO:0031629,GO:0031965,GO:0032028,GO:0032940,GO:0033605,GO:0035493,GO:0042641,GO:0042802,GO:0043005,GO:0043008,GO:0044325,GO:0044877,GO:0045956,GO:0047485,GO:0048278,GO:0048306,GO:0048488,GO:0048787,GO:0050796,GO:0070032,GO:0070033,GO:0070044,GO:0072657,GO:0098978,GO:0099056,GO:2000463" SNARE binding|positive regulation of neurotransmitter secretion|SNAP receptor activity|protein binding|extracellular region|cytosol|plasma membrane|intracellular protein transport|exocytosis|vesicle fusion|neurotransmitter secretion|synaptic vesicle|voltage-gated potassium channel complex|response to gravity|positive regulation of norepinephrine secretion|regulation of synaptic vesicle priming|endomembrane system|glutamate secretion|postsynaptic density|integral component of membrane|synaptic vesicle exocytosis|synaptic vesicle docking|protein sumoylation|calcium-ion regulated exocytosis|cytokine-mediated signaling pathway|calcium channel inhibitor activity|chloride channel inhibitor activity|kinase binding|protein domain specific binding|insulin secretion|secretory granule|integral component of synaptic vesicle membrane|axon|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|nuclear membrane|myosin head/neck binding|secretion by cell|positive regulation of catecholamine secretion|SNARE complex assembly|actomyosin|identical protein binding|neuron projection|ATP-dependent protein binding|ion channel binding|protein-containing complex binding|positive regulation of calcium ion-dependent exocytosis|protein N-terminus binding|vesicle docking|calcium-dependent protein binding|synaptic vesicle endocytosis|presynaptic active zone membrane|regulation of insulin secretion|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex|synaptobrevin 2-SNAP-25-syntaxin-1a complex|protein localization to membrane|glutamatergic synapse|integral component of presynaptic membrane|positive regulation of excitatory postsynaptic potential "hsa04130,hsa04721,hsa04911,hsa05016,hsa05022,hsa05031" SNARE interactions in vesicular transport|Synaptic vesicle cycle|Insulin secretion|Huntington disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction STX1B 178.03446 181.6771183 174.3918017 0.959899647 -0.059044508 0.926274849 1 1.957308046 1.959751218 112755 syntaxin 1B "GO:0000149,GO:0001956,GO:0005102,GO:0005484,GO:0005515,GO:0005634,GO:0005815,GO:0005819,GO:0005829,GO:0005886,GO:0006886,GO:0006887,GO:0006904,GO:0006906,GO:0008021,GO:0010468,GO:0010807,GO:0010977,GO:0012505,GO:0016020,GO:0016021,GO:0016081,GO:0017157,GO:0019901,GO:0019904,GO:0030424,GO:0031201,GO:0031594,GO:0031629,GO:0048278,GO:0048787,GO:0048791,GO:0060025,GO:0061669,GO:0098967,GO:1903422,GO:1904050,GO:1905302,GO:2000463" SNARE binding|positive regulation of neurotransmitter secretion|signaling receptor binding|SNAP receptor activity|protein binding|nucleus|microtubule organizing center|spindle|cytosol|plasma membrane|intracellular protein transport|exocytosis|vesicle docking involved in exocytosis|vesicle fusion|synaptic vesicle|regulation of gene expression|regulation of synaptic vesicle priming|negative regulation of neuron projection development|endomembrane system|membrane|integral component of membrane|synaptic vesicle docking|regulation of exocytosis|protein kinase binding|protein domain specific binding|axon|SNARE complex|neuromuscular junction|synaptic vesicle fusion to presynaptic active zone membrane|vesicle docking|presynaptic active zone membrane|calcium ion-regulated exocytosis of neurotransmitter|regulation of synaptic activity|spontaneous neurotransmitter secretion|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|negative regulation of synaptic vesicle recycling|positive regulation of spontaneous neurotransmitter secretion|negative regulation of macropinocytosis|positive regulation of excitatory postsynaptic potential "hsa04130,hsa04721" SNARE interactions in vesicular transport|Synaptic vesicle cycle STX2 982.0772797 826.1741583 1137.980401 1.377409823 0.461957871 0.191463825 1 4.563010529 6.555873673 2054 syntaxin 2 "GO:0000149,GO:0005198,GO:0005484,GO:0005515,GO:0005615,GO:0005886,GO:0006886,GO:0006887,GO:0006906,GO:0007165,GO:0007340,GO:0007398,GO:0008021,GO:0009887,GO:0012505,GO:0016021,GO:0016323,GO:0030027,GO:0030154,GO:0031201,GO:0031629,GO:0032991,GO:0034599,GO:0043231,GO:0048278,GO:0048306,GO:0048787,GO:1903575" SNARE binding|structural molecule activity|SNAP receptor activity|protein binding|extracellular space|plasma membrane|intracellular protein transport|exocytosis|vesicle fusion|signal transduction|acrosome reaction|ectoderm development|synaptic vesicle|animal organ morphogenesis|endomembrane system|integral component of membrane|basolateral plasma membrane|lamellipodium|cell differentiation|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|protein-containing complex|cellular response to oxidative stress|intracellular membrane-bounded organelle|vesicle docking|calcium-dependent protein binding|presynaptic active zone membrane|cornified envelope assembly "hsa04130,hsa04721" SNARE interactions in vesicular transport|Synaptic vesicle cycle STX3 705.869955 702.3495301 709.3903799 1.010024709 0.014390587 0.973706713 1 5.658849182 5.961781398 6809 syntaxin 3 "GO:0000149,GO:0005484,GO:0005515,GO:0005773,GO:0005886,GO:0005911,GO:0006886,GO:0006887,GO:0006906,GO:0008021,GO:0008284,GO:0012505,GO:0016021,GO:0016081,GO:0016324,GO:0019221,GO:0030027,GO:0030425,GO:0030426,GO:0031175,GO:0031201,GO:0031629,GO:0042470,GO:0042581,GO:0042582,GO:0042589,GO:0043005,GO:0045785,GO:0048278,GO:0048787,GO:0050544,GO:0050921,GO:0060291,GO:0070062,GO:0098685,GO:0098794,GO:0098967,GO:0098978,GO:1903078,GO:2000010" SNARE binding|SNAP receptor activity|protein binding|vacuole|plasma membrane|cell-cell junction|intracellular protein transport|exocytosis|vesicle fusion|synaptic vesicle|positive regulation of cell population proliferation|endomembrane system|integral component of membrane|synaptic vesicle docking|apical plasma membrane|cytokine-mediated signaling pathway|lamellipodium|dendrite|growth cone|neuron projection development|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|melanosome|specific granule|azurophil granule|zymogen granule membrane|neuron projection|positive regulation of cell adhesion|vesicle docking|presynaptic active zone membrane|arachidonic acid binding|positive regulation of chemotaxis|long-term synaptic potentiation|extracellular exosome|Schaffer collateral - CA1 synapse|postsynapse|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|glutamatergic synapse|positive regulation of protein localization to plasma membrane|positive regulation of protein localization to cell surface "hsa04130,hsa04721" SNARE interactions in vesicular transport|Synaptic vesicle cycle STX4 772.2389695 726.7084734 817.7694657 1.125306083 0.170317468 0.647020712 1 20.26719191 23.78921854 6810 syntaxin 4 "GO:0000149,GO:0000322,GO:0002639,GO:0005484,GO:0005515,GO:0005615,GO:0005768,GO:0005773,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006887,GO:0006892,GO:0006906,GO:0008021,GO:0008284,GO:0009986,GO:0012505,GO:0016020,GO:0016021,GO:0016230,GO:0016323,GO:0017157,GO:0019221,GO:0030027,GO:0030335,GO:0030670,GO:0031201,GO:0031629,GO:0034599,GO:0035493,GO:0035749,GO:0035774,GO:0036477,GO:0042581,GO:0043085,GO:0043197,GO:0043219,GO:0043311,GO:0045202,GO:0045785,GO:0048278,GO:0048284,GO:0048471,GO:0048787,GO:0050921,GO:0060291,GO:0070062,GO:0071346,GO:0098794,GO:0098978,GO:1902041,GO:1903078,GO:1903575,GO:1990668,GO:2000010" SNARE binding|storage vacuole|positive regulation of immunoglobulin production|SNAP receptor activity|protein binding|extracellular space|endosome|vacuole|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|exocytosis|post-Golgi vesicle-mediated transport|vesicle fusion|synaptic vesicle|positive regulation of cell population proliferation|cell surface|endomembrane system|membrane|integral component of membrane|sphingomyelin phosphodiesterase activator activity|basolateral plasma membrane|regulation of exocytosis|cytokine-mediated signaling pathway|lamellipodium|positive regulation of cell migration|phagocytic vesicle membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|cellular response to oxidative stress|SNARE complex assembly|myelin sheath adaxonal region|positive regulation of insulin secretion involved in cellular response to glucose stimulus|somatodendritic compartment|specific granule|positive regulation of catalytic activity|dendritic spine|lateral loop|positive regulation of eosinophil degranulation|synapse|positive regulation of cell adhesion|vesicle docking|organelle fusion|perinuclear region of cytoplasm|presynaptic active zone membrane|positive regulation of chemotaxis|long-term synaptic potentiation|extracellular exosome|cellular response to interferon-gamma|postsynapse|glutamatergic synapse|regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of protein localization to plasma membrane|cornified envelope assembly|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane|positive regulation of protein localization to cell surface "hsa04130,hsa04962" SNARE interactions in vesicular transport|Vasopressin-regulated water reabsorption STX5 1058.520141 1067.733679 1049.306604 0.982741881 -0.025115555 0.945470738 1 29.51798258 30.25812874 6811 syntaxin 5 "GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005789,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006906,GO:0012505,GO:0012507,GO:0016021,GO:0031201,GO:0031982,GO:0033116,GO:0034498,GO:0042147,GO:0045296,GO:0045732,GO:0047485,GO:0048208,GO:0048278,GO:0048280,GO:0090166,GO:1903358" "Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|vesicle fusion|endomembrane system|ER to Golgi transport vesicle membrane|integral component of membrane|SNARE complex|vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|early endosome to Golgi transport|retrograde transport, endosome to Golgi|cadherin binding|positive regulation of protein catabolic process|protein N-terminus binding|COPII vesicle coating|vesicle docking|vesicle fusion with Golgi apparatus|Golgi disassembly|regulation of Golgi organization" hsa04130 SNARE interactions in vesicular transport STX6 1066.503455 1108.331917 1024.674993 0.924519972 -0.113223609 0.74708834 1 11.38371561 10.97782402 10228 syntaxin 6 "GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005654,GO:0005769,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006906,GO:0007032,GO:0012505,GO:0016021,GO:0016189,GO:0019905,GO:0030136,GO:0030285,GO:0031201,GO:0032456,GO:0032588,GO:0032880,GO:0042147,GO:0045335,GO:0048193,GO:0048278,GO:0048471,GO:0090161,GO:1903827" "Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|nucleoplasm|early endosome|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|vesicle fusion|endosome organization|endomembrane system|integral component of membrane|synaptic vesicle to endosome fusion|syntaxin binding|clathrin-coated vesicle|integral component of synaptic vesicle membrane|SNARE complex|endocytic recycling|trans-Golgi network membrane|regulation of protein localization|retrograde transport, endosome to Golgi|phagocytic vesicle|Golgi vesicle transport|vesicle docking|perinuclear region of cytoplasm|Golgi ribbon formation|regulation of cellular protein localization" hsa04130 SNARE interactions in vesicular transport STX7 994.8451391 958.1184341 1031.571844 1.076664228 0.106568396 0.764534986 1 2.932929504 3.293804648 8417 syntaxin 7 "GO:0000149,GO:0001772,GO:0001916,GO:0005484,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005886,GO:0006886,GO:0006906,GO:0008021,GO:0012505,GO:0016021,GO:0019869,GO:0019905,GO:0030139,GO:0031201,GO:0031901,GO:0031982,GO:0042582,GO:0048278,GO:0048471,GO:0051640,GO:0055037,GO:0070062,GO:0070820,GO:0070925,GO:1902685,GO:1903076" SNARE binding|immunological synapse|positive regulation of T cell mediated cytotoxicity|SNAP receptor activity|protein binding|lysosome|lysosomal membrane|endosome|early endosome|late endosome|plasma membrane|intracellular protein transport|vesicle fusion|synaptic vesicle|endomembrane system|integral component of membrane|chloride channel inhibitor activity|syntaxin binding|endocytic vesicle|SNARE complex|early endosome membrane|vesicle|azurophil granule|vesicle docking|perinuclear region of cytoplasm|organelle localization|recycling endosome|extracellular exosome|tertiary granule|organelle assembly|positive regulation of receptor localization to synapse|regulation of protein localization to plasma membrane "hsa04130,hsa04145" SNARE interactions in vesicular transport|Phagosome STX8 273.9856554 275.0530674 272.9182434 0.992238501 -0.011241157 0.990079408 1 10.96887208 11.35256445 9482 syntaxin 8 "GO:0000149,GO:0005484,GO:0005515,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005783,GO:0005802,GO:0005829,GO:0005887,GO:0006886,GO:0006906,GO:0008333,GO:0012505,GO:0016021,GO:0019869,GO:0019905,GO:0031201,GO:0031625,GO:0031902,GO:0031982,GO:0045022,GO:0045335,GO:0048278,GO:0048471,GO:0055037,GO:0071346,GO:1903076" SNARE binding|SNAP receptor activity|protein binding|lysosomal membrane|endosome|early endosome|late endosome|endoplasmic reticulum|trans-Golgi network|cytosol|integral component of plasma membrane|intracellular protein transport|vesicle fusion|endosome to lysosome transport|endomembrane system|integral component of membrane|chloride channel inhibitor activity|syntaxin binding|SNARE complex|ubiquitin protein ligase binding|late endosome membrane|vesicle|early endosome to late endosome transport|phagocytic vesicle|vesicle docking|perinuclear region of cytoplasm|recycling endosome|cellular response to interferon-gamma|regulation of protein localization to plasma membrane hsa04130 SNARE interactions in vesicular transport STXBP1 1694.772578 1489.955362 1899.589795 1.274930675 0.350418802 0.283950547 1 13.93040111 18.5253372 6812 syntaxin binding protein 1 "GO:0000149,GO:0002576,GO:0003006,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005856,GO:0005886,GO:0006886,GO:0006904,GO:0007269,GO:0007274,GO:0007412,GO:0010807,GO:0014047,GO:0016082,GO:0016188,GO:0016192,GO:0017075,GO:0019901,GO:0019904,GO:0019905,GO:0030141,GO:0030424,GO:0031091,GO:0031333,GO:0031630,GO:0032229,GO:0032355,GO:0032991,GO:0035493,GO:0035542,GO:0042802,GO:0043274,GO:0043306,GO:0043524,GO:0045335,GO:0045956,GO:0047485,GO:0048471,GO:0048787,GO:0050821,GO:0060292,GO:0070062,GO:0070527,GO:0071346,GO:0072659,GO:0098794,GO:0098978,GO:0099525,GO:0106022,GO:1903296,GO:2000367" "SNARE binding|platelet degranulation|developmental process involved in reproduction|RNA binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|cytoskeleton|plasma membrane|intracellular protein transport|vesicle docking involved in exocytosis|neurotransmitter secretion|neuromuscular synaptic transmission|axon target recognition|regulation of synaptic vesicle priming|glutamate secretion|synaptic vesicle priming|synaptic vesicle maturation|vesicle-mediated transport|syntaxin-1 binding|protein kinase binding|protein domain specific binding|syntaxin binding|secretory granule|axon|platelet alpha granule|negative regulation of protein-containing complex assembly|regulation of synaptic vesicle fusion to presynaptic active zone membrane|negative regulation of synaptic transmission, GABAergic|response to estradiol|protein-containing complex|SNARE complex assembly|regulation of SNARE complex assembly|identical protein binding|phospholipase binding|positive regulation of mast cell degranulation|negative regulation of neuron apoptotic process|phagocytic vesicle|positive regulation of calcium ion-dependent exocytosis|protein N-terminus binding|perinuclear region of cytoplasm|presynaptic active zone membrane|protein stabilization|long-term synaptic depression|extracellular exosome|platelet aggregation|cellular response to interferon-gamma|protein localization to plasma membrane|postsynapse|glutamatergic synapse|presynaptic dense core vesicle exocytosis|positive regulation of vesicle docking|positive regulation of glutamate secretion, neurotransmission|regulation of acrosomal vesicle exocytosis" hsa04721 Synaptic vesicle cycle STXBP2 1275.905795 1245.350973 1306.460616 1.049070218 0.069111245 0.840355058 1 23.66702944 25.89788145 6813 syntaxin binding protein 2 "GO:0001909,GO:0002576,GO:0005515,GO:0005576,GO:0005829,GO:0005886,GO:0006886,GO:0006904,GO:0007269,GO:0016192,GO:0017075,GO:0019905,GO:0030141,GO:0030348,GO:0042581,GO:0042582,GO:0043304,GO:0043312,GO:0044194,GO:0070062,GO:0070820,GO:0098793" leukocyte mediated cytotoxicity|platelet degranulation|protein binding|extracellular region|cytosol|plasma membrane|intracellular protein transport|vesicle docking involved in exocytosis|neurotransmitter secretion|vesicle-mediated transport|syntaxin-1 binding|syntaxin binding|secretory granule|syntaxin-3 binding|specific granule|azurophil granule|regulation of mast cell degranulation|neutrophil degranulation|cytolytic granule|extracellular exosome|tertiary granule|presynapse STXBP3 934.1759109 784.5609636 1083.790858 1.381397888 0.466128923 0.19143538 1 15.96434112 23.00306552 6814 syntaxin binding protein 3 "GO:0001678,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0006904,GO:0007269,GO:0007420,GO:0016192,GO:0016323,GO:0016324,GO:0017075,GO:0019905,GO:0022615,GO:0030073,GO:0030141,GO:0031091,GO:0032868,GO:0042581,GO:0043312,GO:0044877,GO:0045335,GO:0045955,GO:0046325,GO:0070062,GO:0070527,GO:0070820,GO:0071346,GO:0098793" cellular glucose homeostasis|protein binding|cytosol|plasma membrane|intracellular protein transport|vesicle docking involved in exocytosis|neurotransmitter secretion|brain development|vesicle-mediated transport|basolateral plasma membrane|apical plasma membrane|syntaxin-1 binding|syntaxin binding|protein to membrane docking|insulin secretion|secretory granule|platelet alpha granule|response to insulin|specific granule|neutrophil degranulation|protein-containing complex binding|phagocytic vesicle|negative regulation of calcium ion-dependent exocytosis|negative regulation of glucose import|extracellular exosome|platelet aggregation|tertiary granule|cellular response to interferon-gamma|presynapse STXBP4 187.9289199 218.2155332 157.6423066 0.722415606 -0.469099036 0.395234889 1 1.338644251 1.008714413 252983 syntaxin binding protein 4 "GO:0005515,GO:0006605,GO:0006974,GO:0008286,GO:0010827,GO:0010838,GO:0019905,GO:0045335,GO:0050821,GO:0061178,GO:0070062,GO:0071346,GO:1902808" protein binding|protein targeting|cellular response to DNA damage stimulus|insulin receptor signaling pathway|regulation of glucose transmembrane transport|positive regulation of keratinocyte proliferation|syntaxin binding|phagocytic vesicle|protein stabilization|regulation of insulin secretion involved in cellular response to glucose stimulus|extracellular exosome|cellular response to interferon-gamma|positive regulation of cell cycle G1/S phase transition STXBP5 722.3225346 682.0504107 762.5946584 1.118091341 0.161038052 0.669740379 1 3.154076623 3.67845505 134957 syntaxin binding protein 5 "GO:0005096,GO:0005737,GO:0005829,GO:0005886,GO:0005892,GO:0006887,GO:0008021,GO:0010807,GO:0015031,GO:0017075,GO:0017157,GO:0019905,GO:0031201,GO:0031594,GO:0043547,GO:0045159,GO:0045921,GO:0050708,GO:0098674,GO:0098685,GO:0098686,GO:0098888,GO:0099504,GO:0099523,GO:2000300" GTPase activator activity|cytoplasm|cytosol|plasma membrane|acetylcholine-gated channel complex|exocytosis|synaptic vesicle|regulation of synaptic vesicle priming|protein transport|syntaxin-1 binding|regulation of exocytosis|syntaxin binding|SNARE complex|neuromuscular junction|positive regulation of GTPase activity|myosin II binding|positive regulation of exocytosis|regulation of protein secretion|extrinsic component of neuronal dense core vesicle membrane|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|extrinsic component of presynaptic membrane|synaptic vesicle cycle|presynaptic cytosol|regulation of synaptic vesicle exocytosis STXBP6 19.9725123 18.26920743 21.67581716 1.186467297 0.246672336 0.865811425 1 0.103811389 0.128474431 29091 syntaxin binding protein 6 "GO:0000145,GO:0005546,GO:0005886,GO:0005912,GO:0006887,GO:0006893,GO:0016021,GO:0035542,GO:0045920,GO:0051601,GO:0098609,GO:0098641" "exocyst|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane|adherens junction|exocytosis|Golgi to plasma membrane transport|integral component of membrane|regulation of SNARE complex assembly|negative regulation of exocytosis|exocyst localization|cell-cell adhesion|cadherin binding involved in cell-cell adhesion" STYK1 158.9905507 125.8545401 192.1265612 1.526576325 0.610299722 0.294595979 1 1.929787607 3.07286843 55359 serine/threonine/tyrosine kinase 1 "GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005886,GO:0007169,GO:0016021,GO:0030154,GO:0031234,GO:0038083,GO:0042127,GO:0045087" non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|integral component of membrane|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|innate immune response STYX 458.4391799 457.7451417 459.1332181 1.003032422 0.00436824 0.997651045 1 4.927348906 5.155184546 6815 serine/threonine/tyrosine interacting protein "GO:0001691,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0008138,GO:0032091,GO:0043086,GO:0045204,GO:0062026,GO:0070372,GO:1990444" pseudophosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|negative regulation of protein binding|negative regulation of catalytic activity|MAPK export from nucleus|negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process|regulation of ERK1 and ERK2 cascade|F-box domain binding STYXL1 684.0511233 625.2128765 742.8893701 1.188218282 0.248799891 0.513274282 1 11.73205875 14.54073599 51657 serine/threonine/tyrosine interacting like 1 "GO:0001691,GO:0004864,GO:0005515,GO:0005739,GO:0005759,GO:0006470,GO:0008138,GO:0010976,GO:0019903,GO:0032515,GO:0035556,GO:0062030,GO:2001242,GO:2001244" pseudophosphatase activity|protein phosphatase inhibitor activity|protein binding|mitochondrion|mitochondrial matrix|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|positive regulation of neuron projection development|protein phosphatase binding|negative regulation of phosphoprotein phosphatase activity|intracellular signal transduction|negative regulation of stress granule assembly|regulation of intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway SUB1 1547.696751 1707.155939 1388.237563 0.81318732 -0.298340375 0.366515764 1 21.38017453 18.13500894 10923 SUB1 regulator of transcription "GO:0000978,GO:0003697,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0006357,GO:0042802,GO:0051053,GO:0060261,GO:0060395,GO:0070062" RNA polymerase II cis-regulatory region sequence-specific DNA binding|single-stranded DNA binding|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|regulation of transcription by RNA polymerase II|identical protein binding|negative regulation of DNA metabolic process|positive regulation of transcription initiation from RNA polymerase II promoter|SMAD protein signal transduction|extracellular exosome SUCLA2 442.7194866 460.7900096 424.6489635 0.92156721 -0.117838709 0.78397019 1 11.05513426 10.62690908 8803 succinate-CoA ligase ADP-forming subunit beta "GO:0000287,GO:0004775,GO:0004776,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006099,GO:0006104,GO:0006781,GO:0042709,GO:0070062" magnesium ion binding|succinate-CoA ligase (ADP-forming) activity|succinate-CoA ligase (GDP-forming) activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|tricarboxylic acid cycle|succinyl-CoA metabolic process|succinyl-CoA pathway|succinate-CoA ligase complex|extracellular exosome "hsa00020,hsa00640" Citrate cycle (TCA cycle)|Propanoate metabolism SUCLG1 789.1557275 872.8621328 705.4493222 0.808202459 -0.307211354 0.404758087 1 34.80896674 29.34453481 8802 succinate-CoA ligase GDP/ADP-forming subunit alpha "GO:0000166,GO:0003723,GO:0004775,GO:0004776,GO:0005515,GO:0005739,GO:0005759,GO:0006099,GO:0009361" nucleotide binding|RNA binding|succinate-CoA ligase (ADP-forming) activity|succinate-CoA ligase (GDP-forming) activity|protein binding|mitochondrion|mitochondrial matrix|tricarboxylic acid cycle|succinate-CoA ligase complex (ADP-forming) "hsa00020,hsa00640" Citrate cycle (TCA cycle)|Propanoate metabolism SUCLG2 1523.897988 1562.017235 1485.77874 0.951192283 -0.072191084 0.828894329 1 23.94390512 23.75632351 8801 succinate-CoA ligase GDP-forming subunit beta "GO:0000287,GO:0004775,GO:0004776,GO:0005515,GO:0005524,GO:0005525,GO:0005739,GO:0005759,GO:0005886,GO:0006099,GO:0006104,GO:0006105,GO:0019003,GO:0042709,GO:0044877,GO:0045244" magnesium ion binding|succinate-CoA ligase (ADP-forming) activity|succinate-CoA ligase (GDP-forming) activity|protein binding|ATP binding|GTP binding|mitochondrion|mitochondrial matrix|plasma membrane|tricarboxylic acid cycle|succinyl-CoA metabolic process|succinate metabolic process|GDP binding|succinate-CoA ligase complex|protein-containing complex binding|succinate-CoA ligase complex (GDP-forming) "hsa00020,hsa00640" Citrate cycle (TCA cycle)|Propanoate metabolism SUCO 990.5962795 1071.793503 909.3990565 0.848483457 -0.237041563 0.502542149 1 10.46713456 9.26375619 51430 SUN domain containing ossification factor "GO:0001503,GO:0005737,GO:0005791,GO:0007275,GO:0016020,GO:0016021,GO:0030867,GO:0032967,GO:0045669,GO:0046850" ossification|cytoplasm|rough endoplasmic reticulum|multicellular organism development|membrane|integral component of membrane|rough endoplasmic reticulum membrane|positive regulation of collagen biosynthetic process|positive regulation of osteoblast differentiation|regulation of bone remodeling SUDS3 1468.383211 1336.69701 1600.069412 1.197032237 0.259462006 0.435390052 1 10.34519988 12.91697033 64426 "SDS3 homolog, SIN3A corepressor complex component" "GO:0000122,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006915,GO:0016575,GO:0016579,GO:0016580,GO:0016604,GO:0019899,GO:0021762,GO:0042826,GO:0043065,GO:0045892,GO:0070822" "negative regulation of transcription by RNA polymerase II|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytosol|apoptotic process|histone deacetylation|protein deubiquitination|Sin3 complex|nuclear body|enzyme binding|substantia nigra development|histone deacetylase binding|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|Sin3-type complex" SUFU 1328.354176 1362.07091 1294.637443 0.950491956 -0.073253677 0.829711206 1 11.01982212 10.92544059 51684 SUFU negative regulator of hedgehog signaling "GO:0000122,GO:0001501,GO:0001843,GO:0001947,GO:0003281,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0007165,GO:0007275,GO:0008013,GO:0008134,GO:0019901,GO:0021775,GO:0021776,GO:0035904,GO:0042308,GO:0042994,GO:0043433,GO:0043588,GO:0045668,GO:0045879,GO:0060976,GO:0097542,GO:0097546,GO:1901621,GO:2000059" "negative regulation of transcription by RNA polymerase II|skeletal system development|neural tube closure|heart looping|ventricular septum development|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|proteolysis|signal transduction|multicellular organism development|beta-catenin binding|transcription factor binding|protein kinase binding|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|aorta development|negative regulation of protein import into nucleus|cytoplasmic sequestering of transcription factor|negative regulation of DNA-binding transcription factor activity|skin development|negative regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|coronary vasculature development|ciliary tip|ciliary base|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|negative regulation of ubiquitin-dependent protein catabolic process" "hsa04340,hsa05200,hsa05217" Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma SUGCT 13.95700537 11.16451565 16.74949508 1.500243773 0.585196941 0.672252101 1 0.071566046 0.111991429 79783 succinyl-CoA:glutarate-CoA transferase "GO:0005739,GO:0047369" mitochondrion|succinate-hydroxymethylglutarate CoA-transferase activity SUGP1 483.6497756 497.3284245 469.9711267 0.944991486 -0.081626764 0.847373214 1 9.60271835 9.46537918 57794 SURP and G-patch domain containing 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005681" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|spliceosomal complex" SUGP2 1679.02171 1692.946555 1665.096864 0.983549574 -0.023930324 0.94359996 1 11.31755157 11.61086743 10147 SURP and G-patch domain containing 2 "GO:0003723,GO:0005654,GO:0006397,GO:0008380,GO:0016604" RNA binding|nucleoplasm|mRNA processing|RNA splicing|nuclear body SUGT1 655.9777684 726.7084734 585.2470634 0.805339534 -0.312330938 0.415523034 1 2.538641227 2.132535539 10910 "SGT1 homolog, MIS12 kinetochore complex assembly cochaperone" "GO:0000151,GO:0000278,GO:0000776,GO:0005515,GO:0005634,GO:0005829,GO:0031647,GO:0032991,GO:0043947,GO:0050821" ubiquitin ligase complex|mitotic cell cycle|kinetochore|protein binding|nucleus|cytosol|regulation of protein stability|protein-containing complex|positive regulation by host of symbiont catalytic activity|protein stabilization hsa04621 NOD-like receptor signaling pathway SULF1 5.537720498 8.119647747 2.95579325 0.364029739 -1.457871781 0.448526494 1 0.067205673 0.025518711 23213 sulfatase 1 "GO:0001822,GO:0001937,GO:0002063,GO:0003094,GO:0004065,GO:0005509,GO:0005539,GO:0005615,GO:0005783,GO:0005794,GO:0005795,GO:0005886,GO:0006915,GO:0008449,GO:0009986,GO:0010575,GO:0014846,GO:0016525,GO:0030177,GO:0030201,GO:0030336,GO:0030513,GO:0032836,GO:0035860,GO:0040036,GO:0040037,GO:0045121,GO:0048010,GO:0048706,GO:0051216,GO:0060348,GO:0060384,GO:0060686,GO:0062023" kidney development|negative regulation of endothelial cell proliferation|chondrocyte development|glomerular filtration|arylsulfatase activity|calcium ion binding|glycosaminoglycan binding|extracellular space|endoplasmic reticulum|Golgi apparatus|Golgi stack|plasma membrane|apoptotic process|N-acetylglucosamine-6-sulfatase activity|cell surface|positive regulation of vascular endothelial growth factor production|esophagus smooth muscle contraction|negative regulation of angiogenesis|positive regulation of Wnt signaling pathway|heparan sulfate proteoglycan metabolic process|negative regulation of cell migration|positive regulation of BMP signaling pathway|glomerular basement membrane development|glial cell-derived neurotrophic factor receptor signaling pathway|regulation of fibroblast growth factor receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|membrane raft|vascular endothelial growth factor receptor signaling pathway|embryonic skeletal system development|cartilage development|bone development|innervation|negative regulation of prostatic bud formation|collagen-containing extracellular matrix SULF2 22.77712618 41.6131947 3.941057666 0.094706924 -3.400386286 0.005094914 0.273055593 0.433119916 0.042786407 55959 sulfatase 2 "GO:0001822,GO:0002063,GO:0003094,GO:0004065,GO:0005509,GO:0005539,GO:0005615,GO:0005783,GO:0005795,GO:0005886,GO:0008449,GO:0009611,GO:0009986,GO:0010575,GO:0014846,GO:0030177,GO:0030201,GO:0032836,GO:0035860,GO:0040037,GO:0048706,GO:0051216,GO:0060348,GO:0060384,GO:0090263,GO:0097421,GO:2000345" kidney development|chondrocyte development|glomerular filtration|arylsulfatase activity|calcium ion binding|glycosaminoglycan binding|extracellular space|endoplasmic reticulum|Golgi stack|plasma membrane|N-acetylglucosamine-6-sulfatase activity|response to wounding|cell surface|positive regulation of vascular endothelial growth factor production|esophagus smooth muscle contraction|positive regulation of Wnt signaling pathway|heparan sulfate proteoglycan metabolic process|glomerular basement membrane development|glial cell-derived neurotrophic factor receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|embryonic skeletal system development|cartilage development|bone development|innervation|positive regulation of canonical Wnt signaling pathway|liver regeneration|regulation of hepatocyte proliferation SULT1A3 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.189682433 0.153652144 6818 sulfotransferase family 1A member 3 "GO:0004062,GO:0005515,GO:0005737,GO:0005829,GO:0006068,GO:0006805,GO:0007212,GO:0008146,GO:0008202,GO:0009812,GO:0036498,GO:0042420,GO:0043199,GO:0047685,GO:0050427,GO:0051923,GO:0070371,GO:0097720,GO:0098989,GO:1901215,GO:1903351" aryl sulfotransferase activity|protein binding|cytoplasm|cytosol|ethanol catabolic process|xenobiotic metabolic process|dopamine receptor signaling pathway|sulfotransferase activity|steroid metabolic process|flavonoid metabolic process|IRE1-mediated unfolded protein response|dopamine catabolic process|sulfate binding|amine sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|ERK1 and ERK2 cascade|calcineurin-mediated signaling|NMDA selective glutamate receptor signaling pathway|negative regulation of neuron death|cellular response to dopamine hsa05204 Chemical carcinogenesis SULT1A4 7.986035764 7.104691779 8.867379749 1.248101962 0.319735798 0.916631795 1 0.265359568 0.34546237 445329 sulfotransferase family 1A member 4 "GO:0004062,GO:0005515,GO:0005737,GO:0005829,GO:0006068,GO:0006584,GO:0006805,GO:0007212,GO:0008146,GO:0008202,GO:0009812,GO:0036498,GO:0042420,GO:0043199,GO:0047685,GO:0050427,GO:0051923,GO:0070371,GO:0097720,GO:0098989,GO:1901215,GO:1903351" aryl sulfotransferase activity|protein binding|cytoplasm|cytosol|ethanol catabolic process|catecholamine metabolic process|xenobiotic metabolic process|dopamine receptor signaling pathway|sulfotransferase activity|steroid metabolic process|flavonoid metabolic process|IRE1-mediated unfolded protein response|dopamine catabolic process|sulfate binding|amine sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|ERK1 and ERK2 cascade|calcineurin-mediated signaling|NMDA selective glutamate receptor signaling pathway|negative regulation of neuron death|cellular response to dopamine hsa05204 Chemical carcinogenesis SULT1C2 2.463161041 0 4.926322083 Inf Inf 0.189235799 1 0 0.104643473 6819 sulfotransferase family 1C member 2 "GO:0004062,GO:0005515,GO:0005737,GO:0005829,GO:0008146,GO:0009308,GO:0050427,GO:0051923" aryl sulfotransferase activity|protein binding|cytoplasm|cytosol|sulfotransferase activity|amine metabolic process|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation SUMF1 949.7726326 1008.866233 890.6790326 0.882851466 -0.17975736 0.614450746 1 7.135248654 6.570715821 285362 sulfatase modifying factor 1 "GO:0005783,GO:0005788,GO:0006687,GO:0016491,GO:0018158,GO:0042802,GO:0043687,GO:0120147,GO:1903135" endoplasmic reticulum|endoplasmic reticulum lumen|glycosphingolipid metabolic process|oxidoreductase activity|protein oxidation|identical protein binding|post-translational protein modification|Formylglycine-generating oxidase activity|cupric ion binding hsa04142 Lysosome SUMF2 4889.746326 5346.788041 4432.70461 0.829040646 -0.27048526 0.399222577 1 116.8735226 101.0666539 25870 sulfatase modifying factor 2 "GO:0005515,GO:0005783,GO:0005788,GO:0006687,GO:0043687,GO:0046872" protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|glycosphingolipid metabolic process|post-translational protein modification|metal ion binding SUMO1 1791.37402 2031.941849 1550.806192 0.763213865 -0.389840715 0.230722097 1 61.6600877 49.08698063 7341 small ubiquitin like modifier 1 "GO:0000122,GO:0003723,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006281,GO:0006303,GO:0008076,GO:0008134,GO:0015459,GO:0016032,GO:0016604,GO:0016605,GO:0016607,GO:0016925,GO:0019899,GO:0031334,GO:0031386,GO:0031625,GO:0031965,GO:0032436,GO:0032880,GO:0034605,GO:0043392,GO:0043433,GO:0044388,GO:0044389,GO:0045759,GO:0045892,GO:0050821,GO:0060021,GO:0060334,GO:0071276,GO:0097165,GO:1902260,GO:1990381" "negative regulation of transcription by RNA polymerase II|RNA binding|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|nucleolus|cytosol|plasma membrane|DNA repair|double-strand break repair via nonhomologous end joining|voltage-gated potassium channel complex|transcription factor binding|potassium channel regulator activity|viral process|nuclear body|PML body|nuclear speck|protein sumoylation|enzyme binding|positive regulation of protein-containing complex assembly|protein tag|ubiquitin protein ligase binding|nuclear membrane|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of protein localization|cellular response to heat|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|small protein activating enzyme binding|ubiquitin-like protein ligase binding|negative regulation of action potential|negative regulation of transcription, DNA-templated|protein stabilization|roof of mouth development|regulation of interferon-gamma-mediated signaling pathway|cellular response to cadmium ion|nuclear stress granule|negative regulation of delayed rectifier potassium channel activity|ubiquitin-specific protease binding" "hsa03013,hsa05418" RNA transport|Fluid shear stress and atherosclerosis other SUMO2 4652.4708 4685.03675 4619.904849 0.986097889 -0.020197226 0.950383859 1 74.94648881 77.08808374 6613 small ubiquitin like modifier 2 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0016605,GO:0016925,GO:0031386,GO:0031625,GO:0032436,GO:0044389" RNA binding|protein binding|nucleus|nucleoplasm|PML body|protein sumoylation|protein tag|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin-like protein ligase binding "hsa03013,hsa05418" RNA transport|Fluid shear stress and atherosclerosis other SUMO3 3037.201043 3073.286672 3001.115413 0.976516587 -0.034283545 0.915173195 1 83.95422225 85.51417241 6612 small ubiquitin like modifier 3 "GO:0000776,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016605,GO:0016925,GO:0031386,GO:0043392,GO:0044389,GO:1900180" kinetochore|protein binding|nucleus|nucleoplasm|cytoplasm|PML body|protein sumoylation|protein tag|negative regulation of DNA binding|ubiquitin-like protein ligase binding|regulation of protein localization to nucleus "hsa03013,hsa05418" RNA transport|Fluid shear stress and atherosclerosis SUN1 3378.640938 3244.814231 3512.467645 1.082486514 0.114349051 0.719697959 1 24.89221354 28.10618769 23353 Sad1 and UNC84 domain containing 1 "GO:0005515,GO:0005635,GO:0005639,GO:0006998,GO:0007283,GO:0030154,GO:0031965,GO:0034993,GO:0043231,GO:0043495,GO:0051321,GO:0090292,GO:0140444" protein binding|nuclear envelope|integral component of nuclear inner membrane|nuclear envelope organization|spermatogenesis|cell differentiation|nuclear membrane|meiotic nuclear membrane microtubule tethering complex|intracellular membrane-bounded organelle|protein-membrane adaptor activity|meiotic cell cycle|nuclear matrix anchoring at nuclear membrane|cytoskeleton-nuclear membrane anchor activity SUN2 4740.299872 4425.208022 5055.391721 1.142407701 0.192077609 0.54893573 1 39.25064363 46.77177311 25777 Sad1 and UNC84 domain containing 2 "GO:0000781,GO:0000794,GO:0005515,GO:0005521,GO:0005635,GO:0005639,GO:0006998,GO:0007052,GO:0007097,GO:0008017,GO:0010008,GO:0021817,GO:0030335,GO:0031022,GO:0031965,GO:0034993,GO:0042802,GO:0043495,GO:0051321,GO:0051642,GO:0090292,GO:0140444" "chromosome, telomeric region|condensed nuclear chromosome|protein binding|lamin binding|nuclear envelope|integral component of nuclear inner membrane|nuclear envelope organization|mitotic spindle organization|nuclear migration|microtubule binding|endosome membrane|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|positive regulation of cell migration|nuclear migration along microfilament|nuclear membrane|meiotic nuclear membrane microtubule tethering complex|identical protein binding|protein-membrane adaptor activity|meiotic cell cycle|centrosome localization|nuclear matrix anchoring at nuclear membrane|cytoskeleton-nuclear membrane anchor activity" SUN3 26.13647699 35.52345889 16.74949508 0.471505186 -1.084654457 0.295603888 1 1.121657028 0.551648555 256979 Sad1 and UNC84 domain containing 3 "GO:0005635,GO:0005637,GO:0006998,GO:0016021,GO:0034993,GO:0043495" nuclear envelope|nuclear inner membrane|nuclear envelope organization|integral component of membrane|meiotic nuclear membrane microtubule tethering complex|protein-membrane adaptor activity SUOX 496.3812625 525.7471916 467.0153334 0.888288784 -0.17089932 0.679102625 1 3.633629985 3.366749536 6821 sulfite oxidase "GO:0005515,GO:0005739,GO:0005758,GO:0005759,GO:0006790,GO:0008482,GO:0020037,GO:0030151,GO:0043546,GO:0070221" "protein binding|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|sulfur compound metabolic process|sulfite oxidase activity|heme binding|molybdenum ion binding|molybdopterin cofactor binding|sulfide oxidation, using sulfide:quinone oxidoreductase" hsa00920 Sulfur metabolism SUPT16H 5839.747334 5933.432591 5746.062077 0.968421228 -0.046293391 0.886770393 1 64.12877269 64.77883883 11198 "SPT16 homolog, facilitates chromatin remodeling subunit" "GO:0003723,GO:0005515,GO:0005654,GO:0006260,GO:0006281,GO:0006337,GO:0006366,GO:0006368,GO:0016032,GO:0031491,GO:0032786,GO:0032968,GO:0034724,GO:0035101,GO:1901796" "RNA binding|protein binding|nucleoplasm|DNA replication|DNA repair|nucleosome disassembly|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|viral process|nucleosome binding|positive regulation of DNA-templated transcription, elongation|positive regulation of transcription elongation from RNA polymerase II promoter|DNA replication-independent nucleosome organization|FACT complex|regulation of signal transduction by p53 class mediator" SUPT20H 1081.391785 1048.449515 1114.334055 1.062839974 0.087924394 0.802455063 1 15.00855547 16.63882692 55578 "SPT20 homolog, SAGA complex component" "GO:0000124,GO:0003712,GO:0005515,GO:0006357,GO:0006914,GO:0007369,GO:0070461" SAGA complex|transcription coregulator activity|protein binding|regulation of transcription by RNA polymerase II|autophagy|gastrulation|SAGA-type complex hsa04140 Autophagy - animal other SUPT3H 187.8277211 177.6172945 198.0381477 1.114971086 0.157006298 0.782751363 1 0.856650735 0.996284392 8464 "SPT3 homolog, SAGA and STAGA complex component" "GO:0003713,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006366,GO:0016578,GO:0030914,GO:0033276,GO:0043966,GO:0045893,GO:0046982" "transcription coactivator activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|histone deubiquitination|STAGA complex|transcription factor TFTC complex|histone H3 acetylation|positive regulation of transcription, DNA-templated|protein heterodimerization activity" hsa05202 Transcriptional misregulation in cancer SUPT4H1 1219.852365 1218.962118 1220.742612 1.001460664 0.002105755 0.997833424 1 41.48933537 43.33974014 6827 "SPT4 homolog, DSIF elongation factor subunit" "GO:0000122,GO:0000993,GO:0005515,GO:0005654,GO:0006325,GO:0006355,GO:0006366,GO:0006368,GO:0006397,GO:0008270,GO:0032044,GO:0032785,GO:0032786,GO:0034243,GO:0034244,GO:0045944,GO:0046982,GO:0050434" "negative regulation of transcription by RNA polymerase II|RNA polymerase II complex binding|protein binding|nucleoplasm|chromatin organization|regulation of transcription, DNA-templated|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA processing|zinc ion binding|DSIF complex|negative regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of viral transcription" SUPT5H 2039.359532 2247.112514 1831.60655 0.815093387 -0.294962733 0.359516334 1 29.49930573 25.08043671 6829 "SPT5 homolog, DSIF elongation factor subunit" "GO:0000122,GO:0003682,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0006368,GO:0006370,GO:0016239,GO:0019899,GO:0032044,GO:0032785,GO:0032786,GO:0045944,GO:0046982,GO:0050434,GO:1900364" "negative regulation of transcription by RNA polymerase II|chromatin binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|positive regulation of macroautophagy|enzyme binding|DSIF complex|negative regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of viral transcription|negative regulation of mRNA polyadenylation" chromosome_remodelling_factor SUPT6H 4425.322814 4681.991882 4168.653746 0.890359029 -0.167540888 0.600283693 1 35.82510527 33.27120821 6830 "SPT6 homolog, histone chaperone and transcription elongation factor" "GO:0001825,GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0006366,GO:0006368,GO:0006397,GO:0008023,GO:0008380,GO:0010793,GO:0016032,GO:0031491,GO:0032968,GO:0034728,GO:0035327,GO:0042393,GO:0042789,GO:0045191,GO:0050684,GO:0051028,GO:0051147,GO:0061086,GO:0070827" blastocyst formation|DNA binding|RNA binding|protein binding|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA processing|transcription elongation factor complex|RNA splicing|regulation of mRNA export from nucleus|viral process|nucleosome binding|positive regulation of transcription elongation from RNA polymerase II promoter|nucleosome organization|transcriptionally active chromatin|histone binding|mRNA transcription by RNA polymerase II|regulation of isotype switching|regulation of mRNA processing|mRNA transport|regulation of muscle cell differentiation|negative regulation of histone H3-K27 methylation|chromatin maintenance SUPT7L 940.4531986 876.9219567 1003.98444 1.144896 0.195216553 0.584817027 1 9.401567212 11.22747826 9913 "SPT7 like, STAGA complex subunit gamma" "GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0030914,GO:0043966,GO:0045893,GO:0046982,GO:0051457" "transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|STAGA complex|histone H3 acetylation|positive regulation of transcription, DNA-templated|protein heterodimerization activity|maintenance of protein location in nucleus" SUPV3L1 981.4968106 988.5671132 974.426508 0.985695857 -0.020785533 0.956201168 1 18.31958903 18.83538873 6832 Suv3 like RNA helicase "GO:0000958,GO:0000962,GO:0000965,GO:0003677,GO:0003678,GO:0003723,GO:0003724,GO:0003725,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005759,GO:0006310,GO:0006401,GO:0030307,GO:0032508,GO:0034458,GO:0035945,GO:0035946,GO:0042645,GO:0042803,GO:0043066,GO:0045025,GO:0070584,GO:0070827,GO:2000827" mitochondrial mRNA catabolic process|positive regulation of mitochondrial RNA catabolic process|mitochondrial RNA 3'-end processing|DNA binding|DNA helicase activity|RNA binding|RNA helicase activity|double-stranded RNA binding|helicase activity|protein binding|ATP binding|nucleus|mitochondrion|mitochondrial matrix|DNA recombination|RNA catabolic process|positive regulation of cell growth|DNA duplex unwinding|3'-5' RNA helicase activity|mitochondrial ncRNA surveillance|mitochondrial mRNA surveillance|mitochondrial nucleoid|protein homodimerization activity|negative regulation of apoptotic process|mitochondrial degradosome|mitochondrion morphogenesis|chromatin maintenance|mitochondrial RNA surveillance SURF1 660.4762846 663.7812033 657.1713658 0.990042144 -0.014438156 0.974268678 1 27.42102469 28.31739453 6834 SURF1 cytochrome c oxidase assembly factor "GO:0004129,GO:0005515,GO:0005746,GO:0006119,GO:0008535,GO:0009060,GO:0016021,GO:0022900,GO:0033617,GO:0055114,GO:1902600" cytochrome-c oxidase activity|protein binding|mitochondrial respirasome|oxidative phosphorylation|respiratory chain complex IV assembly|aerobic respiration|integral component of membrane|electron transport chain|mitochondrial cytochrome c oxidase assembly|oxidation-reduction process|proton transmembrane transport SURF2 297.8789364 359.2944128 236.46346 0.658132861 -0.603549236 0.203132539 1 21.84513145 14.99630167 6835 surfeit 2 "GO:0003674,GO:0005654,GO:0005730,GO:0005886,GO:0008150,GO:0016607" molecular_function|nucleoplasm|nucleolus|plasma membrane|biological_process|nuclear speck SURF4 7779.360596 7760.353334 7798.367857 1.004898556 0.007049869 0.983381383 1 67.79964111 71.06660139 6836 surfeit 4 "GO:0000139,GO:0005515,GO:0005789,GO:0005793,GO:0005829,GO:0005886,GO:0006890,GO:0007030,GO:0010638,GO:0016021,GO:0030133,GO:0032527,GO:0033116,GO:0034498,GO:0035577,GO:0043312" "Golgi membrane|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|positive regulation of organelle organization|integral component of membrane|transport vesicle|protein exit from endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment membrane|early endosome to Golgi transport|azurophil granule membrane|neutrophil degranulation" SURF6 727.5942689 840.3835418 614.8049959 0.731576673 -0.45091902 0.228822959 1 10.05254173 7.670994368 6838 surfeit 6 "GO:0001652,GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0042273,GO:0042274" granular component|DNA binding|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|ribosomal large subunit biogenesis|ribosomal small subunit biogenesis SUSD1 716.8266298 710.4691779 723.1840817 1.017896489 0.02559086 0.94964877 1 11.15744418 11.84634207 64420 sushi domain containing 1 "GO:0005509,GO:0016021" calcium ion binding|integral component of membrane SUSD2 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.048616588 0.082045498 56241 sushi domain containing 2 "GO:0005515,GO:0005615,GO:0005886,GO:0016021,GO:0051782,GO:0070062,GO:1902807" protein binding|extracellular space|plasma membrane|integral component of membrane|negative regulation of cell division|extracellular exosome|negative regulation of cell cycle G1/S phase transition SUSD3 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.045329752 0.061198899 203328 sushi domain containing 3 "GO:0005515,GO:0005886,GO:0016021" protein binding|plasma membrane|integral component of membrane SUSD5 111.9974958 112.6601125 111.3348791 0.988236889 -0.017071185 0.994755417 1 1.115947048 1.150325054 26032 sushi domain containing 5 "GO:0005540,GO:0007155,GO:0007219,GO:0016021" hyaluronic acid binding|cell adhesion|Notch signaling pathway|integral component of membrane SUSD6 1100.664816 1591.450958 609.8786738 0.383221783 -1.383748526 8.66E-05 0.014137806 14.95387324 5.977503123 9766 sushi domain containing 6 "GO:0003674,GO:0005515,GO:0005575,GO:0006974,GO:0008219,GO:0016021" molecular_function|protein binding|cellular_component|cellular response to DNA damage stimulus|cell death|integral component of membrane SUV39H1 757.522108 697.2747503 817.7694657 1.172808087 0.229966956 0.536978013 1 11.56336158 14.14578287 6839 suppressor of variegation 3-9 homolog 1 "GO:0000122,GO:0000183,GO:0000775,GO:0000792,GO:0000794,GO:0000976,GO:0003682,GO:0005515,GO:0005634,GO:0005652,GO:0005654,GO:0005677,GO:0006325,GO:0006364,GO:0006974,GO:0007049,GO:0008270,GO:0008757,GO:0016032,GO:0018024,GO:0030154,GO:0033553,GO:0034968,GO:0036123,GO:0036124,GO:0042054,GO:0042754,GO:0045892,GO:0046974,GO:0047485,GO:0048511,GO:0071456" "negative regulation of transcription by RNA polymerase II|rDNA heterochromatin assembly|chromosome, centromeric region|heterochromatin|condensed nuclear chromosome|transcription regulatory region sequence-specific DNA binding|chromatin binding|protein binding|nucleus|nuclear lamina|nucleoplasm|chromatin silencing complex|chromatin organization|rRNA processing|cellular response to DNA damage stimulus|cell cycle|zinc ion binding|S-adenosylmethionine-dependent methyltransferase activity|viral process|histone-lysine N-methyltransferase activity|cell differentiation|rDNA heterochromatin|histone lysine methylation|histone H3-K9 dimethylation|histone H3-K9 trimethylation|histone methyltransferase activity|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|rhythmic process|cellular response to hypoxia" hsa00310 Lysine degradation SUV39H2 446.3933203 442.5208022 450.2658384 1.017502084 0.025031749 0.958310698 1 7.866661113 8.349138755 79723 suppressor of variegation 3-9 homolog 2 "GO:0000122,GO:0000775,GO:0000785,GO:0000976,GO:0005515,GO:0005634,GO:0005654,GO:0006333,GO:0006338,GO:0007049,GO:0008270,GO:0030154,GO:0034968,GO:0036123,GO:0036124,GO:0042754,GO:0045892,GO:0046974,GO:0048511,GO:0071456,GO:1904047" "negative regulation of transcription by RNA polymerase II|chromosome, centromeric region|chromatin|transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|chromatin assembly or disassembly|chromatin remodeling|cell cycle|zinc ion binding|cell differentiation|histone lysine methylation|histone H3-K9 dimethylation|histone H3-K9 trimethylation|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K9 specific)|rhythmic process|cellular response to hypoxia|S-adenosyl-L-methionine binding" hsa00310 Lysine degradation SUZ12 1811.71248 1772.113121 1851.311839 1.044691683 0.063077227 0.847459317 1 19.95803378 21.748125 23512 SUZ12 polycomb repressive complex 2 subunit "GO:0001226,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0016604,GO:0021510,GO:0031490,GO:0032526,GO:0032682,GO:0035064,GO:0035098,GO:0042054,GO:0042532,GO:0045596,GO:0045814,GO:0046872,GO:0046976,GO:0050680,GO:0070317,GO:0098532" "RNA polymerase II transcription corepressor binding|protein binding|nucleus|nucleoplasm|nucleolus|nuclear body|spinal cord development|chromatin DNA binding|response to retinoic acid|negative regulation of chemokine production|methylated histone binding|ESC/E(Z) complex|histone methyltransferase activity|negative regulation of tyrosine phosphorylation of STAT protein|negative regulation of cell differentiation|negative regulation of gene expression, epigenetic|metal ion binding|histone methyltransferase activity (H3-K27 specific)|negative regulation of epithelial cell proliferation|negative regulation of G0 to G1 transition|histone H3-K27 trimethylation" other SV2A 675.5657744 516.6125879 834.5189608 1.615367067 0.691862032 0.069639956 1 5.797608038 9.76868273 9900 synaptic vesicle glycoprotein 2A "GO:0005783,GO:0005886,GO:0005911,GO:0006874,GO:0008021,GO:0014052,GO:0016021,GO:0016082,GO:0019901,GO:0022857,GO:0030285,GO:0030425,GO:0030672,GO:0031594,GO:0043005,GO:0043025,GO:0048786,GO:0055085,GO:0098978,GO:0098982" endoplasmic reticulum|plasma membrane|cell-cell junction|cellular calcium ion homeostasis|synaptic vesicle|regulation of gamma-aminobutyric acid secretion|integral component of membrane|synaptic vesicle priming|protein kinase binding|transmembrane transporter activity|integral component of synaptic vesicle membrane|dendrite|synaptic vesicle membrane|neuromuscular junction|neuron projection|neuronal cell body|presynaptic active zone|transmembrane transport|glutamatergic synapse|GABA-ergic synapse hsa04512 ECM-receptor interaction SVBP 199.084033 172.5425146 225.6255514 1.307651925 0.386978571 0.475866875 1 10.90969997 14.88061547 374969 small vasohibin binding protein "GO:0005515,GO:0005576,GO:0005737,GO:0005856,GO:0006508,GO:0008017,GO:0009306,GO:0010596,GO:0031397,GO:0045177,GO:0061564,GO:1905048" protein binding|extracellular region|cytoplasm|cytoskeleton|proteolysis|microtubule binding|protein secretion|negative regulation of endothelial cell migration|negative regulation of protein ubiquitination|apical part of cell|axon development|regulation of metallopeptidase activity SVEP1 4.985705186 4.059823873 5.911586499 1.456118956 0.542128219 0.871693704 1 0.016846846 0.025587709 79987 "sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1" "GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0007155,GO:0016020" calcium ion binding|extracellular region|nucleus|cytoplasm|cell adhesion|membrane SVIL 5520.069117 6542.406172 4497.732062 0.687473682 -0.540623609 0.094589426 1 28.29389398 20.28919092 6840 supervillin "GO:0002102,GO:0005515,GO:0005546,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0007519,GO:0008154,GO:0015629,GO:0030496,GO:0032154,GO:0032467,GO:0036449,GO:0043034,GO:0051014,GO:0051015,GO:0051016,GO:0071437" "podosome|protein binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|skeletal muscle tissue development|actin polymerization or depolymerization|actin cytoskeleton|midbody|cleavage furrow|positive regulation of cytokinesis|microtubule minus-end|costamere|actin filament severing|actin filament binding|barbed-end actin filament capping|invadopodium" SVIP 129.2693146 114.6900244 143.8486048 1.254238157 0.326811315 0.605165175 1 0.908452477 1.188497169 258010 small VCP interacting protein "GO:0000139,GO:0005515,GO:0005789,GO:0005886,GO:0010508,GO:0030667,GO:0030868,GO:0031225,GO:0031333,GO:0043312,GO:0043621,GO:0051117,GO:0070062,GO:0070821,GO:1903061,GO:1903070,GO:1904153,GO:1904240" "Golgi membrane|protein binding|endoplasmic reticulum membrane|plasma membrane|positive regulation of autophagy|secretory granule membrane|smooth endoplasmic reticulum membrane|anchored component of membrane|negative regulation of protein-containing complex assembly|neutrophil degranulation|protein self-association|ATPase binding|extracellular exosome|tertiary granule membrane|positive regulation of protein lipidation|negative regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of retrograde protein transport, ER to cytosol|negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" hsa04141 Protein processing in endoplasmic reticulum SVOPL 5.059934066 9.134603715 0.985264417 0.107860663 -3.212759283 0.136251646 1 0.098495945 0.01108147 136306 SVOP like "GO:0016021,GO:0022857,GO:0055085" integral component of membrane|transmembrane transporter activity|transmembrane transport SWAP70 2233.912882 2143.587005 2324.238759 1.084275447 0.116731303 0.716219525 1 20.62799158 23.32987967 23075 switching B cell complex subunit SWAP70 "GO:0003677,GO:0005509,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0007204,GO:0015629,GO:0030027,GO:0030835,GO:0032233,GO:0032880,GO:0033633,GO:0045190,GO:0045296,GO:0051017,GO:0060754,GO:1902309" DNA binding|calcium ion binding|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|positive regulation of cytosolic calcium ion concentration|actin cytoskeleton|lamellipodium|negative regulation of actin filament depolymerization|positive regulation of actin filament bundle assembly|regulation of protein localization|negative regulation of cell-cell adhesion mediated by integrin|isotype switching|cadherin binding|actin filament bundle assembly|positive regulation of mast cell chemotaxis|negative regulation of peptidyl-serine dephosphorylation SWI5 722.5991611 768.3216681 676.8766542 0.880980821 -0.182817482 0.627719345 1 39.22659477 36.04649089 375757 SWI5 homologous recombination repair protein "GO:0000724,GO:0000730,GO:0005515,GO:0005634,GO:0032798,GO:0071479" double-strand break repair via homologous recombination|DNA recombinase assembly|protein binding|nucleus|Swi5-Sfr1 complex|cellular response to ionizing radiation SWSAP1 29.04773291 32.47859099 25.61687483 0.788731101 -0.342394563 0.755629422 1 1.786021776 1.469371614 126074 SWIM-type zinc finger 7 associated protein 1 "GO:0000724,GO:0003697,GO:0005515,GO:0005634,GO:0016887,GO:0050821,GO:0097196" double-strand break repair via homologous recombination|single-stranded DNA binding|protein binding|nucleus|ATPase activity|protein stabilization|Shu complex SWT1 163.8250765 153.2583512 174.3918017 1.137894283 0.18636653 0.753578436 1 1.023199951 1.214446411 54823 SWT1 RNA endoribonuclease homolog GO:0005634 nucleus SYAP1 1330.965795 1372.220469 1289.711121 0.939871653 -0.089464336 0.792201474 1 11.29499852 11.07313665 94056 synapse associated protein 1 "GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0030154,GO:0030424,GO:0030425,GO:0030426,GO:0031234,GO:0032869,GO:0036120,GO:0038203,GO:0042734,GO:0043204,GO:0045211,GO:0045600,GO:0048471,GO:0070062,GO:0071364,GO:0071902,GO:1990314" protein binding|nucleoplasm|Golgi apparatus|cytosol|cell differentiation|axon|dendrite|growth cone|extrinsic component of cytoplasmic side of plasma membrane|cellular response to insulin stimulus|cellular response to platelet-derived growth factor stimulus|TORC2 signaling|presynaptic membrane|perikaryon|postsynaptic membrane|positive regulation of fat cell differentiation|perinuclear region of cytoplasm|extracellular exosome|cellular response to epidermal growth factor stimulus|positive regulation of protein serine/threonine kinase activity|cellular response to insulin-like growth factor stimulus SYBU 21.8985038 15.22433953 28.57266808 1.876775543 0.908256118 0.41099942 1 0.10449371 0.204558917 55638 syntabulin "GO:0000139,GO:0005515,GO:0005874,GO:0005881,GO:0008017,GO:0016021,GO:0017075,GO:0019894,GO:0019896,GO:0031410,GO:0031982,GO:0043231,GO:0060074,GO:1904115" Golgi membrane|protein binding|microtubule|cytoplasmic microtubule|microtubule binding|integral component of membrane|syntaxin-1 binding|kinesin binding|axonal transport of mitochondrion|cytoplasmic vesicle|vesicle|intracellular membrane-bounded organelle|synapse maturation|axon cytoplasm SYCE1L 30.45140065 27.40381115 33.49899016 1.222420852 0.289741058 0.794348241 1 1.313061835 1.674255975 100130958 synaptonemal complex central element protein 1 like "GO:0000795,GO:0007130,GO:0045111" synaptonemal complex|synaptonemal complex assembly|intermediate filament cytoskeleton SYCE2 5.478337395 4.059823873 6.896850916 1.698805448 0.764520641 0.742562249 1 0.111083607 0.196838274 256126 synaptonemal complex central element protein 2 "GO:0000801,GO:0005515,GO:0005654,GO:0005694,GO:0007130,GO:0051301" central element|protein binding|nucleoplasm|chromosome|synaptonemal complex assembly|cell division SYCE3 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.207552918 0.21016015 644186 synaptonemal complex central element protein 3 "GO:0000801,GO:0005515,GO:0005634,GO:0005694,GO:0007130,GO:0007131,GO:0007283,GO:0043065,GO:0051301" central element|protein binding|nucleus|chromosome|synaptonemal complex assembly|reciprocal meiotic recombination|spermatogenesis|positive regulation of apoptotic process|cell division SYCP2 4.493072978 4.059823873 4.926322083 1.213432463 0.279093814 1 1 0.032767451 0.041473836 10388 synaptonemal complex protein 2 "GO:0000080,GO:0000795,GO:0000800,GO:0003677,GO:0005634,GO:0007130,GO:0007140,GO:0007143,GO:0009566,GO:0043066,GO:0048808,GO:0051301,GO:0140013" mitotic G1 phase|synaptonemal complex|lateral element|DNA binding|nucleus|synaptonemal complex assembly|male meiotic nuclear division|female meiotic nuclear division|fertilization|negative regulation of apoptotic process|male genitalia morphogenesis|cell division|meiotic nuclear division SYDE1 1344.423487 1281.889388 1406.957587 1.097565515 0.134307059 0.690887724 1 19.96407604 22.85575639 85360 synapse defective Rho GTPase homolog 1 "GO:0005096,GO:0005829,GO:0007165,GO:0016477,GO:0030695,GO:0031532,GO:0051056,GO:0051493,GO:0090630,GO:1901165" GTPase activator activity|cytosol|signal transduction|cell migration|GTPase regulator activity|actin cytoskeleton reorganization|regulation of small GTPase mediated signal transduction|regulation of cytoskeleton organization|activation of GTPase activity|positive regulation of trophoblast cell migration SYDE2 76.08260351 82.21143344 69.95377357 0.850900789 -0.232937165 0.766386247 1 0.461200607 0.40934051 84144 synapse defective Rho GTPase homolog 2 "GO:0005096,GO:0005829,GO:0007165,GO:0016477,GO:0051056,GO:0090630" GTPase activator activity|cytosol|signal transduction|cell migration|regulation of small GTPase mediated signal transduction|activation of GTPase activity SYF2 505.6400757 485.1489529 526.1311984 1.084473532 0.116994842 0.777644933 1 13.98468011 15.81930587 25949 SYF2 pre-mRNA splicing factor "GO:0000398,GO:0000974,GO:0001701,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0007095,GO:0007369,GO:0008284,GO:0016607,GO:0048568,GO:0071007,GO:0071013,GO:0071014" "mRNA splicing, via spliceosome|Prp19 complex|in utero embryonic development|RNA binding|protein binding|nucleus|nucleoplasm|mitotic G2 DNA damage checkpoint|gastrulation|positive regulation of cell population proliferation|nuclear speck|embryonic organ development|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex" hsa03040 Spliceosome SYMPK 1414.941401 1320.457715 1509.425086 1.143107476 0.192961054 0.564159608 1 15.83625976 18.88233123 8189 symplekin "GO:0000398,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005847,GO:0005856,GO:0005886,GO:0005923,GO:0006369,GO:0006378,GO:0006406,GO:0007155,GO:0016604,GO:0031124,GO:0032091,GO:0035307,GO:0097165" "mRNA splicing, via spliceosome|protein binding|nucleoplasm|cytoplasm|cytosol|mRNA cleavage and polyadenylation specificity factor complex|cytoskeleton|plasma membrane|bicellular tight junction|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA export from nucleus|cell adhesion|nuclear body|mRNA 3'-end processing|negative regulation of protein binding|positive regulation of protein dephosphorylation|nuclear stress granule" "hsa03015,hsa04530" mRNA surveillance pathway|Tight junction SYN1 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.048041065 0 6853 synapsin I "GO:0000795,GO:0003779,GO:0005215,GO:0005515,GO:0005524,GO:0005794,GO:0005829,GO:0005856,GO:0007268,GO:0007269,GO:0008021,GO:0014069,GO:0019901,GO:0030424,GO:0030425,GO:0030672,GO:0042802,GO:0046928,GO:0048306,GO:0048666,GO:0048786,GO:0050808,GO:0097091,GO:0098685,GO:0098693,GO:0098850,GO:0098993,GO:2000300" synaptonemal complex|actin binding|transporter activity|protein binding|ATP binding|Golgi apparatus|cytosol|cytoskeleton|chemical synaptic transmission|neurotransmitter secretion|synaptic vesicle|postsynaptic density|protein kinase binding|axon|dendrite|synaptic vesicle membrane|identical protein binding|regulation of neurotransmitter secretion|calcium-dependent protein binding|neuron development|presynaptic active zone|synapse organization|synaptic vesicle clustering|Schaffer collateral - CA1 synapse|regulation of synaptic vesicle cycle|extrinsic component of synaptic vesicle membrane|anchored component of synaptic vesicle membrane|regulation of synaptic vesicle exocytosis SYNC 110.9258783 73.07682972 148.7749269 2.035870021 1.025645457 0.118819131 1 0.620883011 1.3184867 81493 "syncoilin, intermediate filament protein" "GO:0005515,GO:0005829,GO:0005882,GO:0030018,GO:0031594,GO:0042383,GO:0045103,GO:0048471" protein binding|cytosol|intermediate filament|Z disc|neuromuscular junction|sarcolemma|intermediate filament-based process|perinuclear region of cytoplasm SYNCRIP 3199.263185 3611.213335 2787.313034 0.771849452 -0.373608615 0.240348938 1 20.18933832 16.25438775 10492 synaptotagmin binding cytoplasmic RNA interacting protein "GO:0000398,GO:0001649,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0006396,GO:0008380,GO:0016020,GO:0016032,GO:0017148,GO:0048027,GO:0070934,GO:0070937,GO:0071013,GO:0071204,GO:0071346,GO:0097452,GO:1990904" "mRNA splicing, via spliceosome|osteoblast differentiation|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|RNA processing|RNA splicing|membrane|viral process|negative regulation of translation|mRNA 5'-UTR binding|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|catalytic step 2 spliceosome|histone pre-mRNA 3'end processing complex|cellular response to interferon-gamma|GAIT complex|ribonucleoprotein complex" SYNDIG1L 8.463822196 6.08973581 10.83790858 1.779700946 0.831634837 0.617753532 1 0.05615871 0.104250965 646658 synapse differentiation inducing 1 like "GO:0005794,GO:0016021" Golgi apparatus|integral component of membrane SYNE1 479.6844696 428.3114187 531.0575205 1.239886441 0.310207993 0.453613822 1 0.758504226 0.98097027 23345 spectrin repeat containing nuclear envelope protein 1 "GO:0000932,GO:0003723,GO:0003779,GO:0005515,GO:0005521,GO:0005634,GO:0005635,GO:0005640,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005856,GO:0006997,GO:0007030,GO:0007283,GO:0016021,GO:0019899,GO:0030017,GO:0031965,GO:0034993,GO:0042692,GO:0042803,GO:0045211,GO:0051015,GO:0090292,GO:0140444" P-body|RNA binding|actin binding|protein binding|lamin binding|nucleus|nuclear envelope|nuclear outer membrane|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytoskeleton|nucleus organization|Golgi organization|spermatogenesis|integral component of membrane|enzyme binding|sarcomere|nuclear membrane|meiotic nuclear membrane microtubule tethering complex|muscle cell differentiation|protein homodimerization activity|postsynaptic membrane|actin filament binding|nuclear matrix anchoring at nuclear membrane|cytoskeleton-nuclear membrane anchor activity SYNE2 3282.78995 2653.094901 3912.484998 1.474687165 0.560408938 0.078640911 1 5.644608158 8.682596706 23224 spectrin repeat containing nuclear envelope protein 2 "GO:0003779,GO:0005515,GO:0005634,GO:0005635,GO:0005640,GO:0005654,GO:0005737,GO:0005739,GO:0005925,GO:0007097,GO:0016021,GO:0016529,GO:0021817,GO:0030018,GO:0030335,GO:0031022,GO:0031258,GO:0031527,GO:0031965,GO:0031981,GO:0033017,GO:0034993,GO:0045111,GO:0051015,GO:0051642,GO:0070062,GO:0140444,GO:1902017" actin binding|protein binding|nucleus|nuclear envelope|nuclear outer membrane|nucleoplasm|cytoplasm|mitochondrion|focal adhesion|nuclear migration|integral component of membrane|sarcoplasmic reticulum|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|Z disc|positive regulation of cell migration|nuclear migration along microfilament|lamellipodium membrane|filopodium membrane|nuclear membrane|nuclear lumen|sarcoplasmic reticulum membrane|meiotic nuclear membrane microtubule tethering complex|intermediate filament cytoskeleton|actin filament binding|centrosome localization|extracellular exosome|cytoskeleton-nuclear membrane anchor activity|regulation of cilium assembly SYNE3 138.599635 112.6601125 164.5391576 1.460491685 0.546454145 0.370619128 1 0.357374249 0.544425269 161176 spectrin repeat containing nuclear envelope family member 3 "GO:0005515,GO:0005635,GO:0005640,GO:0005737,GO:0005791,GO:0007010,GO:0007097,GO:0008360,GO:0016020,GO:0016021,GO:0031965,GO:0034993,GO:0051015,GO:0090150,GO:0140444" protein binding|nuclear envelope|nuclear outer membrane|cytoplasm|rough endoplasmic reticulum|cytoskeleton organization|nuclear migration|regulation of cell shape|membrane|integral component of membrane|nuclear membrane|meiotic nuclear membrane microtubule tethering complex|actin filament binding|establishment of protein localization to membrane|cytoskeleton-nuclear membrane anchor activity SYNGAP1 576.7275714 495.2985126 658.1566303 1.328808009 0.410132674 0.298951066 1 4.17112111 5.78137269 8831 synaptic Ras GTPase activating protein 1 "GO:0000165,GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0007265,GO:0007389,GO:0008542,GO:0014069,GO:0016358,GO:0017124,GO:0043113,GO:0043198,GO:0043408,GO:0043524,GO:0043547,GO:0046580,GO:0048167,GO:0048169,GO:0050771,GO:0050803,GO:0098880,GO:0098978" MAPK cascade|GTPase activator activity|protein binding|cytosol|plasma membrane|Ras protein signal transduction|pattern specification process|visual learning|postsynaptic density|dendrite development|SH3 domain binding|receptor clustering|dendritic shaft|regulation of MAPK cascade|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|regulation of synaptic plasticity|regulation of long-term neuronal synaptic plasticity|negative regulation of axonogenesis|regulation of synapse structure or activity|maintenance of postsynaptic specialization structure|glutamatergic synapse hsa04014 Ras signaling pathway SYNGR1 593.9169966 592.7342855 595.0997076 1.003990696 0.005745899 0.993200278 1 5.646022291 5.912732157 9145 synaptogyrin 1 "GO:0005515,GO:0005886,GO:0006605,GO:0030285,GO:0030672,GO:0031594,GO:0035577,GO:0042470,GO:0043312,GO:0045055,GO:0048169,GO:0048172,GO:0048499,GO:1990830" protein binding|plasma membrane|protein targeting|integral component of synaptic vesicle membrane|synaptic vesicle membrane|neuromuscular junction|azurophil granule membrane|melanosome|neutrophil degranulation|regulated exocytosis|regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle membrane organization|cellular response to leukemia inhibitory factor SYNGR2 1540.481458 1584.346267 1496.616649 0.944627245 -0.082182949 0.805084658 1 52.41120128 51.6416977 9144 synaptogyrin 2 "GO:0005515,GO:0005811,GO:0016021,GO:0016032,GO:0030672,GO:0031594,GO:0045055,GO:0048499,GO:0070062" protein binding|lipid droplet|integral component of membrane|viral process|synaptic vesicle membrane|neuromuscular junction|regulated exocytosis|synaptic vesicle membrane organization|extracellular exosome SYNGR3 311.1881708 258.8137719 363.5625697 1.404726522 0.490289288 0.29481917 1 6.469893637 9.479923943 9143 synaptogyrin 3 "GO:0005515,GO:0008021,GO:0016021,GO:0021762,GO:0030672,GO:0031594,GO:0032411,GO:0045055" protein binding|synaptic vesicle|integral component of membrane|substantia nigra development|synaptic vesicle membrane|neuromuscular junction|positive regulation of transporter activity|regulated exocytosis SYNJ1 434.9170433 398.8776956 470.9563911 1.18070375 0.239647024 0.57380473 1 2.819110818 3.471914492 8867 synaptojanin 1 "GO:0003723,GO:0004438,GO:0004439,GO:0005829,GO:0005874,GO:0006661,GO:0006836,GO:0007420,GO:0007612,GO:0012506,GO:0016082,GO:0016191,GO:0017124,GO:0030117,GO:0030132,GO:0034595,GO:0043195,GO:0043647,GO:0043812,GO:0046488,GO:0046855,GO:0046856,GO:0048471,GO:0048488,GO:0048489,GO:0061024,GO:0097060,GO:0098793,GO:1904980" "RNA binding|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|cytosol|microtubule|phosphatidylinositol biosynthetic process|neurotransmitter transport|brain development|learning|vesicle membrane|synaptic vesicle priming|synaptic vesicle uncoating|SH3 domain binding|membrane coat|clathrin coat of coated pit|phosphatidylinositol phosphate 5-phosphatase activity|terminal bouton|inositol phosphate metabolic process|phosphatidylinositol-4-phosphate phosphatase activity|phosphatidylinositol metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|synaptic vesicle endocytosis|synaptic vesicle transport|membrane organization|synaptic membrane|presynapse|positive regulation of endosome organization" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system SYNJ2 1901.298304 2305.97996 1496.616649 0.649015462 -0.623675246 0.054364782 1 11.03768547 7.472208598 8871 synaptojanin 2 "GO:0003723,GO:0004439,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0006661,GO:0007420,GO:0017124,GO:0030165,GO:0042995,GO:0045121,GO:0046855,GO:0046856,GO:0048471,GO:0048488,GO:0061024,GO:0098793" "RNA binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding|cytosol|cytoskeleton|plasma membrane|phosphatidylinositol biosynthetic process|brain development|SH3 domain binding|PDZ domain binding|cell projection|membrane raft|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|synaptic vesicle endocytosis|membrane organization|presynapse" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system SYNJ2BP 664.8478697 693.2149264 636.4808131 0.918157975 -0.123185695 0.749770983 1 4.975044708 4.76464259 55333 synaptojanin 2 binding protein "GO:0001937,GO:0005515,GO:0005739,GO:0005741,GO:0007268,GO:0008328,GO:0008593,GO:0009790,GO:0010596,GO:0016323,GO:0016525,GO:0030054,GO:0031594,GO:0043005,GO:0043113,GO:0045197,GO:0070373,GO:0097120,GO:0098609,GO:0098839,GO:1903671" negative regulation of endothelial cell proliferation|protein binding|mitochondrion|mitochondrial outer membrane|chemical synaptic transmission|ionotropic glutamate receptor complex|regulation of Notch signaling pathway|embryo development|negative regulation of endothelial cell migration|basolateral plasma membrane|negative regulation of angiogenesis|cell junction|neuromuscular junction|neuron projection|receptor clustering|establishment or maintenance of epithelial cell apical/basal polarity|negative regulation of ERK1 and ERK2 cascade|receptor localization to synapse|cell-cell adhesion|postsynaptic density membrane|negative regulation of sprouting angiogenesis SYNM 737.4078189 770.35158 704.4640578 0.914470842 -0.128990925 0.732212614 1 5.931223759 5.657572142 23336 synemin "GO:0005200,GO:0005515,GO:0005882,GO:0005912,GO:0008307,GO:0017166,GO:0019215,GO:0031443,GO:0042383,GO:0043034,GO:0045104,GO:0045111,GO:0060053" structural constituent of cytoskeleton|protein binding|intermediate filament|adherens junction|structural constituent of muscle|vinculin binding|intermediate filament binding|fast-twitch skeletal muscle fiber contraction|sarcolemma|costamere|intermediate filament cytoskeleton organization|intermediate filament cytoskeleton|neurofilament cytoskeleton SYNPO 400.6958073 652.6166877 148.7749269 0.227966783 -2.133104469 2.37E-06 0.000868226 3.113189501 0.740274957 11346 synaptopodin "GO:0001725,GO:0003779,GO:0005515,GO:0005634,GO:0005829,GO:0005923,GO:0014069,GO:0015629,GO:0030018,GO:0032233,GO:0043197,GO:0043204,GO:0097444,GO:0098886,GO:1905355" stress fiber|actin binding|protein binding|nucleus|cytosol|bicellular tight junction|postsynaptic density|actin cytoskeleton|Z disc|positive regulation of actin filament bundle assembly|dendritic spine|perikaryon|spine apparatus|modification of dendritic spine|spine apparatus assembly hsa04530 Tight junction SYNPO2 22.97284287 21.31407534 24.63161041 1.155649965 0.208704486 0.883604912 1 0.078382423 0.094484577 171024 synaptopodin 2 "GO:0000045,GO:0001725,GO:0003779,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0015629,GO:0030018,GO:0030674,GO:0031005,GO:0032233,GO:0043231,GO:0051371,GO:0051393,GO:0061684,GO:0071889,GO:0099023" autophagosome assembly|stress fiber|actin binding|protein binding|nucleus|nucleoplasm|cytosol|focal adhesion|actin cytoskeleton|Z disc|protein-macromolecule adaptor activity|filamin binding|positive regulation of actin filament bundle assembly|intracellular membrane-bounded organelle|muscle alpha-actinin binding|alpha-actinin binding|chaperone-mediated autophagy|14-3-3 protein binding|vesicle tethering complex SYNRG 1329.795701 1258.545401 1401.046 1.113226427 0.154747063 0.647025086 1 7.335813634 8.518197927 11276 synergin gamma "GO:0005515,GO:0005737,GO:0005794,GO:0006886,GO:0006897,GO:0030121,GO:0030130" protein binding|cytoplasm|Golgi apparatus|intracellular protein transport|endocytosis|AP-1 adaptor complex|clathrin coat of trans-Golgi network vesicle SYP 34.01859232 35.52345889 32.51372575 0.915274772 -0.127723179 0.924623465 1 0.74313832 0.70947497 6855 synaptophysin "GO:0005515,GO:0006897,GO:0008021,GO:0015485,GO:0016188,GO:0017075,GO:0030285,GO:0030672,GO:0031594,GO:0042169,GO:0042734,GO:0042802,GO:0043005,GO:0043195,GO:0043621,GO:0048168,GO:0048169,GO:0048172,GO:0048471,GO:0048488,GO:0048499,GO:0048786,GO:0060076,GO:0071310,GO:0098685,GO:2000300,GO:2000474" protein binding|endocytosis|synaptic vesicle|cholesterol binding|synaptic vesicle maturation|syntaxin-1 binding|integral component of synaptic vesicle membrane|synaptic vesicle membrane|neuromuscular junction|SH2 domain binding|presynaptic membrane|identical protein binding|neuron projection|terminal bouton|protein self-association|regulation of neuronal synaptic plasticity|regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|perinuclear region of cytoplasm|synaptic vesicle endocytosis|synaptic vesicle membrane organization|presynaptic active zone|excitatory synapse|cellular response to organic substance|Schaffer collateral - CA1 synapse|regulation of synaptic vesicle exocytosis|regulation of opioid receptor signaling pathway SYPL1 2410.460043 2257.262074 2563.658012 1.135737867 0.183629893 0.565639172 1 47.08499213 55.77974669 6856 synaptophysin like 1 "GO:0005515,GO:0005887,GO:0007268,GO:0016021,GO:0017075,GO:0030141,GO:0030285,GO:0030672,GO:0042470,GO:0070062" protein binding|integral component of plasma membrane|chemical synaptic transmission|integral component of membrane|syntaxin-1 binding|secretory granule|integral component of synaptic vesicle membrane|synaptic vesicle membrane|melanosome|extracellular exosome SYPL2 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.040894144 0.027605231 284612 synaptophysin like 2 "GO:0006874,GO:0007507,GO:0016021,GO:0017075,GO:0021762,GO:0030672,GO:0033292" cellular calcium ion homeostasis|heart development|integral component of membrane|syntaxin-1 binding|substantia nigra development|synaptic vesicle membrane|T-tubule organization SYS1 1695.50794 1809.666492 1581.349389 0.873834707 -0.194567687 0.552263429 1 17.24750163 15.72068315 90196 SYS1 golgi trafficking protein "GO:0005515,GO:0005802,GO:0005829,GO:0006895,GO:0030173,GO:0032588,GO:0034067,GO:0043001" protein binding|trans-Golgi network|cytosol|Golgi to endosome transport|integral component of Golgi membrane|trans-Golgi network membrane|protein localization to Golgi apparatus|Golgi to plasma membrane protein transport SYT11 32.27075013 50.74779842 13.79370183 0.271808872 -1.879335549 0.057649736 1 0.489002466 0.138640657 23208 synaptotagmin 11 "GO:0000149,GO:0001778,GO:0001786,GO:0001818,GO:0001891,GO:0005509,GO:0005515,GO:0005544,GO:0005764,GO:0005765,GO:0005802,GO:0005886,GO:0006906,GO:0006914,GO:0007612,GO:0007613,GO:0008021,GO:0014059,GO:0014069,GO:0016192,GO:0017156,GO:0017158,GO:0030276,GO:0030424,GO:0030425,GO:0030665,GO:0031369,GO:0031625,GO:0031982,GO:0032009,GO:0032715,GO:0032720,GO:0033602,GO:0042802,GO:0043005,GO:0043195,GO:0043197,GO:0043204,GO:0045202,GO:0045335,GO:0045806,GO:0046929,GO:0048471,GO:0048487,GO:0048787,GO:0050765,GO:0051650,GO:0055037,GO:0055038,GO:0060076,GO:0060077,GO:0070382,GO:0071277,GO:0098685,GO:0098793,GO:0099059,GO:1900186,GO:1900243,GO:1900424,GO:1903979,GO:1905154,GO:1905162,GO:1905171,GO:1905469,GO:1990927" SNARE binding|plasma membrane repair|phosphatidylserine binding|negative regulation of cytokine production|phagocytic cup|calcium ion binding|protein binding|calcium-dependent phospholipid binding|lysosome|lysosomal membrane|trans-Golgi network|plasma membrane|vesicle fusion|autophagy|learning|memory|synaptic vesicle|regulation of dopamine secretion|postsynaptic density|vesicle-mediated transport|calcium-ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|clathrin binding|axon|dendrite|clathrin-coated vesicle membrane|translation initiation factor binding|ubiquitin protein ligase binding|vesicle|early phagosome|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|negative regulation of dopamine secretion|identical protein binding|neuron projection|terminal bouton|dendritic spine|perikaryon|synapse|phagocytic vesicle|negative regulation of endocytosis|negative regulation of neurotransmitter secretion|perinuclear region of cytoplasm|beta-tubulin binding|presynaptic active zone membrane|negative regulation of phagocytosis|establishment of vesicle localization|recycling endosome|recycling endosome membrane|excitatory synapse|inhibitory synapse|exocytic vesicle|cellular response to calcium ion|Schaffer collateral - CA1 synapse|presynapse|integral component of presynaptic active zone membrane|negative regulation of clathrin-dependent endocytosis|negative regulation of synaptic vesicle endocytosis|regulation of defense response to bacterium|negative regulation of microglial cell activation|negative regulation of membrane invagination|regulation of phagosome maturation|positive regulation of protein localization to phagocytic vesicle|negative regulation of clathrin-coated pit assembly|calcium ion regulated lysosome exocytosis SYT12 90.24472813 141.0788796 39.41057666 0.279351358 -1.839847259 0.010565924 0.437006183 1.321951444 0.385196401 91683 synaptotagmin 12 "GO:0000149,GO:0001786,GO:0005509,GO:0005544,GO:0005886,GO:0014059,GO:0016021,GO:0016192,GO:0017156,GO:0017158,GO:0019905,GO:0030276,GO:0030672,GO:0046928,GO:0048792,GO:0060291,GO:0070382,GO:0071277,GO:0098686" SNARE binding|phosphatidylserine binding|calcium ion binding|calcium-dependent phospholipid binding|plasma membrane|regulation of dopamine secretion|integral component of membrane|vesicle-mediated transport|calcium-ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|syntaxin binding|clathrin binding|synaptic vesicle membrane|regulation of neurotransmitter secretion|spontaneous exocytosis of neurotransmitter|long-term synaptic potentiation|exocytic vesicle|cellular response to calcium ion|hippocampal mossy fiber to CA3 synapse SYT16 17.1057937 24.35894324 9.852644165 0.404477488 -1.305868687 0.270147201 1 0.070412336 0.029707017 83851 synaptotagmin 16 "GO:0005515,GO:0005543,GO:0006887,GO:0042802" protein binding|phospholipid binding|exocytosis|identical protein binding SYT17 18.56884455 23.34398727 13.79370183 0.590888852 -0.759041315 0.520965803 1 0.252950493 0.155903999 51760 synaptotagmin 17 "GO:0000149,GO:0001786,GO:0005509,GO:0005515,GO:0005544,GO:0005886,GO:0014059,GO:0016192,GO:0017156,GO:0017158,GO:0019905,GO:0030154,GO:0030276,GO:0070382,GO:0071277,GO:1903861" SNARE binding|phosphatidylserine binding|calcium ion binding|protein binding|calcium-dependent phospholipid binding|plasma membrane|regulation of dopamine secretion|vesicle-mediated transport|calcium-ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|syntaxin binding|cell differentiation|clathrin binding|exocytic vesicle|cellular response to calcium ion|positive regulation of dendrite extension SYT5 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.033915069 0 6861 synaptotagmin 5 "GO:0000149,GO:0001786,GO:0005509,GO:0005544,GO:0005546,GO:0005886,GO:0007268,GO:0014059,GO:0016192,GO:0017156,GO:0017158,GO:0019905,GO:0030276,GO:0030424,GO:0030672,GO:0031045,GO:0043025,GO:0046982,GO:0048471,GO:0048488,GO:0048791,GO:0055038,GO:0070382,GO:0071277,GO:0099066,GO:1990769" "SNARE binding|phosphatidylserine binding|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane|chemical synaptic transmission|regulation of dopamine secretion|vesicle-mediated transport|calcium-ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|syntaxin binding|clathrin binding|axon|synaptic vesicle membrane|dense core granule|neuronal cell body|protein heterodimerization activity|perinuclear region of cytoplasm|synaptic vesicle endocytosis|calcium ion-regulated exocytosis of neurotransmitter|recycling endosome membrane|exocytic vesicle|cellular response to calcium ion|integral component of neuronal dense core vesicle membrane|proximal neuron projection" SYTL1 62.82879281 51.76275439 73.89483124 1.427567604 0.513559067 0.521807439 1 1.21765021 1.813155958 84958 synaptotagmin like 1 "GO:0005515,GO:0005886,GO:0006886,GO:0006887,GO:0019897,GO:0031528,GO:0042043,GO:0042470,GO:0070062,GO:0070382" protein binding|plasma membrane|intracellular protein transport|exocytosis|extrinsic component of plasma membrane|microvillus membrane|neurexin family protein binding|melanosome|extracellular exosome|exocytic vesicle SYTL2 199.6872666 281.1428032 118.23173 0.420539771 -1.249685852 0.021688602 0.640846954 1.427744026 0.626286939 54843 synaptotagmin like 2 "GO:0001786,GO:0005515,GO:0005546,GO:0005737,GO:0005886,GO:0006886,GO:0006887,GO:0006904,GO:0010923,GO:0016020,GO:0016192,GO:0019897,GO:0019902,GO:0042043,GO:0042470,GO:0070382" "phosphatidylserine binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|plasma membrane|intracellular protein transport|exocytosis|vesicle docking involved in exocytosis|negative regulation of phosphatase activity|membrane|vesicle-mediated transport|extrinsic component of plasma membrane|phosphatase binding|neurexin family protein binding|melanosome|exocytic vesicle" SYTL3 23.49516663 23.34398727 23.646346 1.012952317 0.018566263 1 1 0.223495388 0.236142142 94120 synaptotagmin like 3 "GO:0005515,GO:0005544,GO:0005886,GO:0006886,GO:0006887,GO:0019897,GO:0042043,GO:0070382" protein binding|calcium-dependent phospholipid binding|plasma membrane|intracellular protein transport|exocytosis|extrinsic component of plasma membrane|neurexin family protein binding|exocytic vesicle SYTL4 368.6007309 277.0829794 460.1184825 1.660580103 0.731687318 0.099970472 1 2.048354315 3.547977368 94121 synaptotagmin like 4 "GO:0001778,GO:0002576,GO:0005515,GO:0005543,GO:0005768,GO:0005886,GO:0006886,GO:0006887,GO:0019898,GO:0030658,GO:0031092,GO:0032418,GO:0042043,GO:0045921,GO:0046676,GO:0046872,GO:0050714,GO:0070382,GO:0071985,GO:1905684" plasma membrane repair|platelet degranulation|protein binding|phospholipid binding|endosome|plasma membrane|intracellular protein transport|exocytosis|extrinsic component of membrane|transport vesicle membrane|platelet alpha granule membrane|lysosome localization|neurexin family protein binding|positive regulation of exocytosis|negative regulation of insulin secretion|metal ion binding|positive regulation of protein secretion|exocytic vesicle|multivesicular body sorting pathway|regulation of plasma membrane repair SYVN1 1424.974916 1299.14364 1550.806192 1.193714186 0.255457449 0.444316517 1 16.87536349 21.01209815 84447 synoviolin 1 "GO:0000836,GO:0000839,GO:0002327,GO:0005515,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005790,GO:0006511,GO:0016020,GO:0016567,GO:0030176,GO:0030433,GO:0030970,GO:0036498,GO:0036503,GO:0036513,GO:0044322,GO:0046872,GO:0050821,GO:0051082,GO:0051087,GO:0051117,GO:0061630,GO:0070936,GO:1902236,GO:1904380,GO:1990381" "Hrd1p ubiquitin ligase complex|Hrd1p ubiquitin ligase ERAD-L complex|immature B cell differentiation|protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|smooth endoplasmic reticulum|ubiquitin-dependent protein catabolic process|membrane|protein ubiquitination|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|IRE1-mediated unfolded protein response|ERAD pathway|Derlin-1 retrotranslocation complex|endoplasmic reticulum quality control compartment|metal ion binding|protein stabilization|unfolded protein binding|chaperone binding|ATPase binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|endoplasmic reticulum mannose trimming|ubiquitin-specific protease binding" "hsa04120,hsa04141" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum SZRD1 3305.097954 3875.101887 2735.09402 0.705812157 -0.502643816 0.114508242 1 56.3966207 41.52007657 26099 SUZ RNA binding domain containing 1 SZT2 1362.064967 1511.269437 1212.860497 0.802544184 -0.317347273 0.344731298 1 6.648754825 5.565769286 23334 SZT2 subunit of KICSTOR complex "GO:0003674,GO:0005515,GO:0005765,GO:0005777,GO:0007417,GO:0009791,GO:0021540,GO:0034198,GO:0042149,GO:0043473,GO:0061462,GO:0061700,GO:0140007,GO:1901668,GO:1904262,GO:1990130" molecular_function|protein binding|lysosomal membrane|peroxisome|central nervous system development|post-embryonic development|corpus callosum morphogenesis|cellular response to amino acid starvation|cellular response to glucose starvation|pigmentation|protein localization to lysosome|GATOR2 complex|KICSTOR complex|regulation of superoxide dismutase activity|negative regulation of TORC1 signaling|GATOR1 complex TAB1 1003.596474 916.5052394 1090.687709 1.190050708 0.251023048 0.47657621 1 12.0848105 15.0010356 10454 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 "GO:0000185,GO:0000187,GO:0001701,GO:0002223,GO:0002755,GO:0003007,GO:0003279,GO:0004724,GO:0005515,GO:0005634,GO:0005829,GO:0006469,GO:0006470,GO:0007179,GO:0007249,GO:0007254,GO:0008047,GO:0010008,GO:0016579,GO:0016607,GO:0019209,GO:0030324,GO:0032991,GO:0035904,GO:0038095,GO:0044877,GO:0048273,GO:0051092,GO:0060976,GO:0070423,GO:0070498" activation of MAPKKK activity|activation of MAPK activity|in utero embryonic development|stimulatory C-type lectin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|heart morphogenesis|cardiac septum development|magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|cytosol|negative regulation of protein kinase activity|protein dephosphorylation|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|enzyme activator activity|endosome membrane|protein deubiquitination|nuclear speck|kinase activator activity|lung development|protein-containing complex|aorta development|Fc-epsilon receptor signaling pathway|protein-containing complex binding|mitogen-activated protein kinase p38 binding|positive regulation of NF-kappaB transcription factor activity|coronary vasculature development|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway "hsa04010,hsa04064,hsa04380,hsa04620,hsa04621,hsa04668,hsa05130,hsa05131,hsa05132,hsa05135,hsa05140,hsa05145,hsa05161,hsa05168,hsa05169,hsa05170" MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|TNF signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Leishmaniasis|Toxoplasmosis|Hepatitis B|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection TAB2 1915.463397 1960.894931 1870.031863 0.953662449 -0.068449383 0.833624502 1 15.71398902 15.63137052 23118 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 "GO:0000187,GO:0002223,GO:0002755,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0007249,GO:0007254,GO:0007507,GO:0010008,GO:0010507,GO:0032496,GO:0038095,GO:0043123,GO:0043130,GO:0045860,GO:0046872,GO:0050852,GO:0051092,GO:0070423,GO:0070498,GO:0070530" activation of MAPK activity|stimulatory C-type lectin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein binding|nucleoplasm|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|JNK cascade|heart development|endosome membrane|negative regulation of autophagy|response to lipopolysaccharide|Fc-epsilon receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|positive regulation of protein kinase activity|metal ion binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding "hsa04010,hsa04064,hsa04380,hsa04620,hsa04621,hsa04657,hsa04668,hsa05130,hsa05131,hsa05132,hsa05135,hsa05140,hsa05145,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05171" MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Leishmaniasis|Toxoplasmosis|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 TAB3 1400.672634 1287.979124 1513.366144 1.174992759 0.232651866 0.487156772 1 6.849180902 8.394401875 257397 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 "GO:0000187,GO:0002223,GO:0002755,GO:0005515,GO:0005829,GO:0005886,GO:0007249,GO:0007254,GO:0010008,GO:0010507,GO:0038095,GO:0043123,GO:0043130,GO:0046872,GO:0051092,GO:0070062,GO:0070423,GO:0070498" activation of MAPK activity|stimulatory C-type lectin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein binding|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|negative regulation of autophagy|Fc-epsilon receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|metal ion binding|positive regulation of NF-kappaB transcription factor activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway "hsa04064,hsa04621,hsa04657,hsa04668,hsa05130,hsa05131,hsa05132" NF-kappa B signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection TACC1 1433.723529 1291.023992 1576.423066 1.221064114 0.288138953 0.387751126 1 5.95770485 7.588105871 6867 transforming acidic coiled-coil containing protein 1 "GO:0000226,GO:0005515,GO:0005634,GO:0005737,GO:0005815,GO:0005829,GO:0007052,GO:0008283,GO:0016020,GO:0016922,GO:0021987,GO:0030331,GO:0030374,GO:0030496,GO:0035259,GO:0042974,GO:0042975,GO:0045893,GO:0046965,GO:0046966,GO:0051301" "microtubule cytoskeleton organization|protein binding|nucleus|cytoplasm|microtubule organizing center|cytosol|mitotic spindle organization|cell population proliferation|membrane|nuclear receptor binding|cerebral cortex development|estrogen receptor binding|nuclear receptor coactivator activity|midbody|glucocorticoid receptor binding|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|positive regulation of transcription, DNA-templated|retinoid X receptor binding|thyroid hormone receptor binding|cell division" TACC2 184.8395147 209.0809295 160.5980999 0.76811453 -0.380606654 0.494008314 1 0.875358476 0.701338777 10579 transforming acidic coiled-coil containing protein 2 "GO:0000226,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005886,GO:0007052,GO:0008283,GO:0021987,GO:0035257" microtubule cytoskeleton organization|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|plasma membrane|mitotic spindle organization|cell population proliferation|cerebral cortex development|nuclear hormone receptor binding TACC3 1860.052541 1742.679398 1977.425684 1.13470423 0.182316296 0.574256555 1 26.98274647 31.93631154 10460 transforming acidic coiled-coil containing protein 3 "GO:0000226,GO:0000922,GO:0005515,GO:0005737,GO:0005829,GO:0007052,GO:0007091,GO:0008283,GO:0021987,GO:0034451,GO:0043231,GO:0051301,GO:0060236,GO:0072686,GO:1902850" microtubule cytoskeleton organization|spindle pole|protein binding|cytoplasm|cytosol|mitotic spindle organization|metaphase/anaphase transition of mitotic cell cycle|cell population proliferation|cerebral cortex development|centriolar satellite|intracellular membrane-bounded organelle|cell division|regulation of mitotic spindle organization|mitotic spindle|microtubule cytoskeleton organization involved in mitosis hsa03013 RNA transport TACO1 577.4023123 642.467128 512.3374966 0.797453246 -0.326528158 0.408479765 1 22.50255432 18.71772139 51204 translational activator of cytochrome c oxidase I "GO:0003729,GO:0005515,GO:0005739,GO:0019843,GO:0033617,GO:0061743,GO:0070129,GO:0097177,GO:1904959" mRNA binding|protein binding|mitochondrion|rRNA binding|mitochondrial cytochrome c oxidase assembly|motor learning|regulation of mitochondrial translation|mitochondrial ribosome binding|regulation of cytochrome-c oxidase activity TACR2 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.018933311 0.076684587 6865 tachykinin receptor 2 "GO:0004995,GO:0005515,GO:0005886,GO:0005887,GO:0006936,GO:0007186,GO:0007217,GO:0007588,GO:0014057,GO:0014827,GO:0016497,GO:0033685,GO:0035106,GO:0036126,GO:0043117,GO:0051602,GO:0061827,GO:0070459,GO:0070474,GO:0097225,GO:1902093" "tachykinin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|muscle contraction|G protein-coupled receptor signaling pathway|tachykinin receptor signaling pathway|excretion|positive regulation of acetylcholine secretion, neurotransmission|intestine smooth muscle contraction|substance K receptor activity|negative regulation of luteinizing hormone secretion|operant conditioning|sperm flagellum|positive regulation of vascular permeability|response to electrical stimulus|sperm head|prolactin secretion|positive regulation of uterine smooth muscle contraction|sperm midpiece|positive regulation of flagellated sperm motility" "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction TACSTD2 940.7689192 1033.225176 848.3126626 0.821033674 -0.2844867 0.424929719 1 28.75231327 24.62349475 4070 tumor associated calcium signal transducer 2 "GO:0005515,GO:0005615,GO:0005634,GO:0005829,GO:0007601,GO:0009925,GO:0010633,GO:0016020,GO:0016021,GO:0016328,GO:0050896,GO:0051497,GO:0070062,GO:0090191,GO:1900025,GO:1900028,GO:2000146,GO:2000738" protein binding|extracellular space|nucleus|cytosol|visual perception|basal plasma membrane|negative regulation of epithelial cell migration|membrane|integral component of membrane|lateral plasma membrane|response to stimulus|negative regulation of stress fiber assembly|extracellular exosome|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of ruffle assembly|negative regulation of cell motility|positive regulation of stem cell differentiation TADA1 231.802878 220.2454451 243.3603109 1.104950483 0.143981718 0.785753719 1 5.321877298 6.133715141 117143 transcriptional adaptor 1 "GO:0000124,GO:0003713,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006357,GO:0030914,GO:0043966,GO:0045893" "SAGA complex|transcription coactivator activity|nucleus|nucleoplasm|cytosol|focal adhesion|regulation of transcription by RNA polymerase II|STAGA complex|histone H3 acetylation|positive regulation of transcription, DNA-templated" TADA2A 371.9491953 404.9674314 338.9309593 0.836933869 -0.256814463 0.564250763 1 4.409841273 3.849727868 6871 transcriptional adaptor 2A "GO:0000125,GO:0003677,GO:0003682,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005694,GO:0006338,GO:0006357,GO:0035066,GO:0043966,GO:0045893,GO:0070461" "PCAF complex|DNA binding|chromatin binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|chromosome|chromatin remodeling|regulation of transcription by RNA polymerase II|positive regulation of histone acetylation|histone H3 acetylation|positive regulation of transcription, DNA-templated|SAGA-type complex" TADA2B 402.373626 396.8477836 407.8994685 1.027848675 0.039627879 0.933015931 1 3.674394926 3.93940782 93624 transcriptional adaptor 2B "GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0006357,GO:0008270,GO:0016579,GO:0030914,GO:0035066,GO:0045893,GO:0070461" "chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|chromatin remodeling|regulation of transcription by RNA polymerase II|zinc ion binding|protein deubiquitination|STAGA complex|positive regulation of histone acetylation|positive regulation of transcription, DNA-templated|SAGA-type complex" TADA3 2564.771206 2467.357959 2662.184454 1.078961585 0.1096435 0.73166113 1 40.75765698 45.87025158 10474 transcriptional adaptor 3 "GO:0000124,GO:0000278,GO:0001932,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0006357,GO:0010628,GO:0016579,GO:0016922,GO:0019904,GO:0030374,GO:0030520,GO:0030914,GO:0031063,GO:0031647,GO:0033276,GO:0043966,GO:0043967,GO:0045893,GO:0072686,GO:0090043" "SAGA complex|mitotic cell cycle|regulation of protein phosphorylation|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|regulation of transcription by RNA polymerase II|positive regulation of gene expression|protein deubiquitination|nuclear receptor binding|protein domain specific binding|nuclear receptor coactivator activity|intracellular estrogen receptor signaling pathway|STAGA complex|regulation of histone deacetylation|regulation of protein stability|transcription factor TFTC complex|histone H3 acetylation|histone H4 acetylation|positive regulation of transcription, DNA-templated|mitotic spindle|regulation of tubulin deacetylation" hsa05165 Human papillomavirus infection TAF1 1698.979376 1710.200807 1687.757946 0.986877061 -0.019057721 0.95541951 1 11.03665107 11.36099311 6872 TATA-box binding protein associated factor 1 "GO:0000122,GO:0000209,GO:0000785,GO:0000979,GO:0001181,GO:0002039,GO:0004402,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005667,GO:0005669,GO:0005730,GO:0006361,GO:0006366,GO:0006367,GO:0006468,GO:0006511,GO:0006974,GO:0007049,GO:0008134,GO:0010629,GO:0016032,GO:0016251,GO:0016301,GO:0016573,GO:0017025,GO:0018105,GO:0018107,GO:0030901,GO:0032092,GO:0032436,GO:0034644,GO:0035257,GO:0036369,GO:0043433,GO:0043565,GO:0046777,GO:0046982,GO:0050821,GO:0051123,GO:0061628,GO:0061629,GO:0061631,GO:0070577,GO:0071318,GO:0071339,GO:0106310,GO:0106311,GO:0140416,GO:1901796,GO:1902806,GO:1903026,GO:1905502,GO:1905524,GO:2000059,GO:2000825" negative regulation of transcription by RNA polymerase II|protein polyubiquitination|chromatin|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase I general transcription initiation factor activity|p53 binding|histone acetyltransferase activity|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription regulator complex|transcription factor TFIID complex|nucleolus|transcription initiation from RNA polymerase I promoter|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein phosphorylation|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|cell cycle|transcription factor binding|negative regulation of gene expression|viral process|RNA polymerase II general transcription initiation factor activity|kinase activity|histone acetylation|TBP-class protein binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|midbrain development|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to UV|nuclear hormone receptor binding|transcription factor catabolic process|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|protein autophosphorylation|protein heterodimerization activity|protein stabilization|RNA polymerase II preinitiation complex assembly|H3K27me3 modified histone binding|RNA polymerase II-specific DNA-binding transcription factor binding|ubiquitin conjugating enzyme activity|lysine-acetylated histone binding|cellular response to ATP|MLL1 complex|protein serine kinase activity|protein threonine kinase activity|transcription regulator inhibitor activity|regulation of signal transduction by p53 class mediator|regulation of cell cycle G1/S phase transition|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|acetyl-CoA binding|negative regulation of protein autoubiquitination|negative regulation of ubiquitin-dependent protein catabolic process|positive regulation of androgen receptor activity hsa03022 Basal transcription factors other TAF10 1200.64639 1320.457715 1080.835065 0.818530615 -0.288891718 0.398569421 1 12.58970726 10.74896105 6881 TATA-box binding protein associated factor 10 "GO:0000082,GO:0000125,GO:0003677,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005737,GO:0006352,GO:0006366,GO:0006367,GO:0006915,GO:0010468,GO:0016251,GO:0016578,GO:0016579,GO:0019899,GO:0030331,GO:0030914,GO:0033276,GO:0034622,GO:0035264,GO:0042802,GO:0043966,GO:0048471,GO:0051101,GO:0070063,GO:0070365,GO:1901796,GO:1990841" "G1/S transition of mitotic cell cycle|PCAF complex|DNA binding|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|cytoplasm|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|apoptotic process|regulation of gene expression|RNA polymerase II general transcription initiation factor activity|histone deubiquitination|protein deubiquitination|enzyme binding|estrogen receptor binding|STAGA complex|transcription factor TFTC complex|cellular protein-containing complex assembly|multicellular organism growth|identical protein binding|histone H3 acetylation|perinuclear region of cytoplasm|regulation of DNA binding|RNA polymerase binding|hepatocyte differentiation|regulation of signal transduction by p53 class mediator|promoter-specific chromatin binding" hsa03022 Basal transcription factors TAF11 296.166229 309.5615704 282.7708875 0.913456044 -0.130592787 0.788770768 1 6.141089491 5.851254792 6882 TATA-box binding protein associated factor 11 "GO:0003713,GO:0005515,GO:0005654,GO:0005669,GO:0005794,GO:0006366,GO:0006367,GO:0008134,GO:0016251,GO:0017025,GO:0042795,GO:0042809,GO:0043923,GO:0045893,GO:0046966,GO:0046982,GO:0047485,GO:0051123,GO:1901796" "transcription coactivator activity|protein binding|nucleoplasm|transcription factor TFIID complex|Golgi apparatus|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|snRNA transcription by RNA polymerase II|vitamin D receptor binding|positive regulation by host of viral transcription|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|protein heterodimerization activity|protein N-terminus binding|RNA polymerase II preinitiation complex assembly|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF12 277.0305233 281.1428032 272.9182434 0.970745971 -0.042834281 0.937385444 1 6.204309879 6.282246992 6883 TATA-box binding protein associated factor 12 "GO:0000124,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0006352,GO:0006366,GO:0006367,GO:0008134,GO:0016251,GO:0017025,GO:0030914,GO:0033276,GO:0043966,GO:0045893,GO:0046695,GO:0046982,GO:0051091,GO:0051123,GO:1901796" "SAGA complex|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|STAGA complex|transcription factor TFTC complex|histone H3 acetylation|positive regulation of transcription, DNA-templated|SLIK (SAGA-like) complex|protein heterodimerization activity|positive regulation of DNA-binding transcription factor activity|RNA polymerase II preinitiation complex assembly|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF13 360.3393064 352.189721 368.4888918 1.046279519 0.065268326 0.889871948 1 21.91298147 23.91471035 6884 TATA-box binding protein associated factor 13 "GO:0003677,GO:0005515,GO:0005654,GO:0005669,GO:0005730,GO:0006352,GO:0006366,GO:0006367,GO:0008022,GO:0016251,GO:0017025,GO:0042795,GO:0046982,GO:1901796" "DNA binding|protein binding|nucleoplasm|transcription factor TFIID complex|nucleolus|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein C-terminus binding|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|snRNA transcription by RNA polymerase II|protein heterodimerization activity|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF15 3938.525488 4339.951721 3537.099255 0.815008895 -0.29511229 0.354465501 1 101.6666255 86.42844251 8148 TATA-box binding protein associated factor 15 "GO:0003677,GO:0003712,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006366,GO:0006367,GO:0045893,GO:0046872,GO:0048255,GO:1901796" "DNA binding|transcription coregulator activity|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-templated|metal ion binding|mRNA stabilization|regulation of signal transduction by p53 class mediator" "hsa03022,hsa05202" Basal transcription factors|Transcriptional misregulation in cancer TAF1A 297.4362847 295.3521868 299.5203826 1.014112629 0.020217889 0.973842847 1 3.308680894 3.49991103 9015 "TATA-box binding protein associated factor, RNA polymerase I subunit A" "GO:0000120,GO:0003677,GO:0005515,GO:0005654,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0015630,GO:0045815" "RNA polymerase I transcription regulator complex|DNA binding|protein binding|nucleoplasm|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|microtubule cytoskeleton|positive regulation of gene expression, epigenetic" TAF1B 221.6505967 233.4398727 209.8613207 0.898995181 -0.153614712 0.774702337 1 4.466530422 4.188356014 9014 "TATA-box binding protein associated factor, RNA polymerase I subunit B" "GO:0001164,GO:0001188,GO:0005515,GO:0005634,GO:0005654,GO:0005668,GO:0005730,GO:0006351,GO:0006361,GO:0006362,GO:0006363,GO:0017025,GO:0042790,GO:0045815,GO:0046872,GO:0070860" "RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I preinitiation complex assembly|protein binding|nucleus|nucleoplasm|RNA polymerase transcription factor SL1 complex|nucleolus|transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|TBP-class protein binding|nucleolar large rRNA transcription by RNA polymerase I|positive regulation of gene expression, epigenetic|metal ion binding|RNA polymerase I core factor complex" TAF1C 557.3907059 554.1659587 560.615453 1.0116382 0.01669342 0.971501265 1 6.746767026 7.119292945 9013 "TATA-box binding protein associated factor, RNA polymerase I subunit C" "GO:0001164,GO:0001181,GO:0001188,GO:0001650,GO:0005515,GO:0005654,GO:0005730,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0045815" "RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I general transcription initiation factor activity|RNA polymerase I preinitiation complex assembly|fibrillar center|protein binding|nucleoplasm|nucleolus|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|positive regulation of gene expression, epigenetic" TAF1D 624.3238599 617.0932288 631.554491 1.023434485 0.033418752 0.935546583 1 19.15048717 20.443526 79101 "TATA-box binding protein associated factor, RNA polymerase I subunit D" "GO:0003677,GO:0005515,GO:0005654,GO:0005668,GO:0005730,GO:0005829,GO:0006355,GO:0006361,GO:0006362,GO:0006363,GO:0034451,GO:0042802,GO:0045815,GO:0072686" "DNA binding|protein binding|nucleoplasm|RNA polymerase transcription factor SL1 complex|nucleolus|cytosol|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|centriolar satellite|identical protein binding|positive regulation of gene expression, epigenetic|mitotic spindle" TAF1L 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.024808851 0 138474 TATA-box binding protein associated factor 1 like "GO:0003677,GO:0004402,GO:0004674,GO:0005575,GO:0005654,GO:0005669,GO:0006357,GO:0006366,GO:0006367,GO:0006468,GO:0007140,GO:0016251,GO:0016573,GO:0017025,GO:0045893,GO:0051123,GO:0070577,GO:1901796" "DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|cellular_component|nucleoplasm|transcription factor TFIID complex|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein phosphorylation|male meiotic nuclear division|RNA polymerase II general transcription initiation factor activity|histone acetylation|TBP-class protein binding|positive regulation of transcription, DNA-templated|RNA polymerase II preinitiation complex assembly|lysine-acetylated histone binding|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF2 2339.853055 2212.604011 2467.102099 1.115021977 0.157072146 0.623627203 1 19.91126289 23.15784611 6873 TATA-box binding protein associated factor 2 "GO:0000086,GO:0000976,GO:0003682,GO:0005515,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0014070,GO:0016251,GO:0033276,GO:1901796" G2/M transition of mitotic cell cycle|transcription regulatory region sequence-specific DNA binding|chromatin binding|protein binding|nucleoplasm|transcription factor TFIID complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|response to organic cyclic compound|RNA polymerase II general transcription initiation factor activity|transcription factor TFTC complex|regulation of signal transduction by p53 class mediator hsa03022 Basal transcription factors TAF3 357.0096472 360.3093688 353.7099255 0.981683953 -0.026669462 0.959314649 1 3.743261217 3.83299062 83860 TATA-box binding protein associated factor 3 "GO:0000122,GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0016251,GO:0031965,GO:0043433,GO:0046872,GO:0046982,GO:0051457,GO:0140416,GO:1901796" negative regulation of transcription by RNA polymerase II|p53 binding|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|RNA polymerase II general transcription initiation factor activity|nuclear membrane|negative regulation of DNA-binding transcription factor activity|metal ion binding|protein heterodimerization activity|maintenance of protein location in nucleus|transcription regulator inhibitor activity|regulation of signal transduction by p53 class mediator hsa03022 Basal transcription factors other TAF4 870.6681717 821.0993784 920.2369651 1.120737622 0.164448566 0.650622006 1 8.849922718 10.34568757 6874 TATA-box binding protein associated factor 4 "GO:0000785,GO:0001046,GO:0001541,GO:0003677,GO:0005515,GO:0005654,GO:0005669,GO:0005829,GO:0006352,GO:0006366,GO:0006367,GO:0016032,GO:0016251,GO:0017162,GO:0032991,GO:0033276,GO:0046982,GO:0071339,GO:1901796" "chromatin|core promoter sequence-specific DNA binding|ovarian follicle development|DNA binding|protein binding|nucleoplasm|transcription factor TFIID complex|cytosol|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|viral process|RNA polymerase II general transcription initiation factor activity|aryl hydrocarbon receptor binding|protein-containing complex|transcription factor TFTC complex|protein heterodimerization activity|MLL1 complex|regulation of signal transduction by p53 class mediator" "hsa03022,hsa05016" Basal transcription factors|Huntington disease TAF4B 301.6918253 283.1727152 320.2109354 1.130797277 0.177340315 0.711610938 1 2.61280726 3.081825598 6875 TATA-box binding protein associated factor 4b "GO:0001650,GO:0003677,GO:0005654,GO:0005669,GO:0005737,GO:0006366,GO:0006367,GO:0007283,GO:0016251,GO:0046982,GO:0048477,GO:0051059,GO:1901796" fibrillar center|DNA binding|nucleoplasm|transcription factor TFIID complex|cytoplasm|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|spermatogenesis|RNA polymerase II general transcription initiation factor activity|protein heterodimerization activity|oogenesis|NF-kappaB binding|regulation of signal transduction by p53 class mediator "hsa03022,hsa05016" Basal transcription factors|Huntington disease TAF5 384.5646377 391.7730038 377.3562715 0.963201313 -0.054090737 0.90771005 1 6.088346287 6.116913532 6877 TATA-box binding protein associated factor 5 "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005730,GO:0006352,GO:0006355,GO:0006366,GO:0006367,GO:0015629,GO:0016032,GO:0016251,GO:0033276,GO:0042795,GO:0042802,GO:0043966,GO:1901796" "chromatin|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|nucleolus|DNA-templated transcription, initiation|regulation of transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|actin cytoskeleton|viral process|RNA polymerase II general transcription initiation factor activity|transcription factor TFTC complex|snRNA transcription by RNA polymerase II|identical protein binding|histone H3 acetylation|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF5L 831.925655 866.772397 797.078913 0.919594251 -0.120930648 0.742274807 1 6.451934762 6.188738674 27097 TATA-box binding protein associated factor 5 like "GO:0003713,GO:0005515,GO:0005634,GO:0006355,GO:0006366,GO:0016607,GO:0030914,GO:0033276,GO:0036464,GO:0043966,GO:0045893,GO:1904672" "transcription coactivator activity|protein binding|nucleus|regulation of transcription, DNA-templated|transcription by RNA polymerase II|nuclear speck|STAGA complex|transcription factor TFTC complex|cytoplasmic ribonucleoprotein granule|histone H3 acetylation|positive regulation of transcription, DNA-templated|regulation of somatic stem cell population maintenance" hsa03022 Basal transcription factors TAF6 2675.357116 2315.114564 3035.599667 1.311209266 0.390897954 0.220105659 1 34.29435081 46.90406958 6878 TATA-box binding protein associated factor 6 "GO:0000124,GO:0003677,GO:0003713,GO:0005515,GO:0005654,GO:0005669,GO:0005829,GO:0006352,GO:0006366,GO:0006367,GO:0006915,GO:0016251,GO:0016573,GO:0017162,GO:0032991,GO:0033276,GO:0042795,GO:0045786,GO:0045944,GO:0046695,GO:0046982,GO:0071339,GO:1901796" "SAGA complex|DNA binding|transcription coactivator activity|protein binding|nucleoplasm|transcription factor TFIID complex|cytosol|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|apoptotic process|RNA polymerase II general transcription initiation factor activity|histone acetylation|aryl hydrocarbon receptor binding|protein-containing complex|transcription factor TFTC complex|snRNA transcription by RNA polymerase II|negative regulation of cell cycle|positive regulation of transcription by RNA polymerase II|SLIK (SAGA-like) complex|protein heterodimerization activity|MLL1 complex|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF6L 368.5628746 375.5337083 361.5920409 0.962875057 -0.054579489 0.908228617 1 8.415689169 8.452312646 10629 TATA-box binding protein associated factor 6 like "GO:0000118,GO:0000124,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0006338,GO:0006355,GO:0006357,GO:0006367,GO:0016251,GO:0016573,GO:0030914,GO:0043966,GO:0045944,GO:0046695,GO:0046982,GO:0070062,GO:1904672" "histone deacetylase complex|SAGA complex|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|chromatin remodeling|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|RNA polymerase II general transcription initiation factor activity|histone acetylation|STAGA complex|histone H3 acetylation|positive regulation of transcription by RNA polymerase II|SLIK (SAGA-like) complex|protein heterodimerization activity|extracellular exosome|regulation of somatic stem cell population maintenance" hsa03022 Basal transcription factors TAF7 1702.894948 1472.70111 1933.088785 1.312614469 0.392443241 0.229951379 1 32.49983261 44.49735956 6879 TATA-box binding protein associated factor 7 "GO:0000122,GO:0000296,GO:0000976,GO:0001097,GO:0005515,GO:0005654,GO:0005667,GO:0005669,GO:0005737,GO:0006352,GO:0006357,GO:0006366,GO:0006367,GO:0006469,GO:0008134,GO:0016251,GO:0030520,GO:0033276,GO:0035035,GO:0035067,GO:0042809,GO:0045344,GO:0045347,GO:0045892,GO:0045944,GO:0046966,GO:0046982,GO:0051123,GO:0061628,GO:0071339,GO:0090241,GO:0106140,GO:1901796" "negative regulation of transcription by RNA polymerase II|spermine transport|transcription regulatory region sequence-specific DNA binding|TFIIH-class transcription factor complex binding|protein binding|nucleoplasm|transcription regulator complex|transcription factor TFIID complex|cytoplasm|DNA-templated transcription, initiation|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|negative regulation of protein kinase activity|transcription factor binding|RNA polymerase II general transcription initiation factor activity|intracellular estrogen receptor signaling pathway|transcription factor TFTC complex|histone acetyltransferase binding|negative regulation of histone acetylation|vitamin D receptor binding|negative regulation of MHC class I biosynthetic process|negative regulation of MHC class II biosynthetic process|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|protein heterodimerization activity|RNA polymerase II preinitiation complex assembly|H3K27me3 modified histone binding|MLL1 complex|negative regulation of histone H4 acetylation|P-TEFb complex binding|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors other TAF8 464.1429256 443.5357582 484.7500929 1.092922237 0.128190755 0.761958084 1 3.610337745 4.115788258 129685 TATA-box binding protein associated factor 8 "GO:0001112,GO:0001833,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0006367,GO:0016251,GO:0030154,GO:0042795,GO:0045598,GO:0046982,GO:0048471,GO:0051457" DNA-templated transcription open complex formation|inner cell mass cell proliferation|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription initiation from RNA polymerase II promoter|RNA polymerase II general transcription initiation factor activity|cell differentiation|snRNA transcription by RNA polymerase II|regulation of fat cell differentiation|protein heterodimerization activity|perinuclear region of cytoplasm|maintenance of protein location in nucleus hsa03022 Basal transcription factors TAF9 1250.326776 1146.900244 1353.753308 1.180358375 0.23922495 0.482077273 1 43.64121063 53.73120806 6880 TATA-box binding protein associated factor 9 "GO:0000124,GO:0000125,GO:0000492,GO:0000976,GO:0002039,GO:0003677,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0006974,GO:0016251,GO:0030914,GO:0032435,GO:0033276,GO:0033613,GO:0042795,GO:0043066,GO:0043966,GO:0045944,GO:0046982,GO:0050821,GO:0051117,GO:0060760,GO:0070555,GO:0070742,GO:0070761,GO:0071339,GO:1901796,GO:1902166" SAGA complex|PCAF complex|box C/D snoRNP assembly|transcription regulatory region sequence-specific DNA binding|p53 binding|DNA binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|cellular response to DNA damage stimulus|RNA polymerase II general transcription initiation factor activity|STAGA complex|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|transcription factor TFTC complex|activating transcription factor binding|snRNA transcription by RNA polymerase II|negative regulation of apoptotic process|histone H3 acetylation|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|protein stabilization|ATPase binding|positive regulation of response to cytokine stimulus|response to interleukin-1|C2H2 zinc finger domain binding|pre-snoRNP complex|MLL1 complex|regulation of signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator hsa03022 Basal transcription factors TAF9B 740.8077477 632.3175683 849.2979271 1.343150925 0.425621425 0.254266448 1 12.0529372 16.88626651 51616 TATA-box binding protein associated factor 9b "GO:0000122,GO:0003714,GO:0005515,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0016251,GO:0016579,GO:0030307,GO:0033276,GO:0043066,GO:0046982,GO:0050821,GO:1901796,GO:1902166" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleoplasm|transcription factor TFIID complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|RNA polymerase II general transcription initiation factor activity|protein deubiquitination|positive regulation of cell growth|transcription factor TFTC complex|negative regulation of apoptotic process|protein heterodimerization activity|protein stabilization|regulation of signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator hsa03022 Basal transcription factors TAFA2 5.015396738 6.08973581 3.941057666 0.64716398 -0.627796782 0.826813936 1 0.067994629 0.045899174 338811 TAFA chemokine like family member 2 "GO:0005615,GO:0005634,GO:0005737,GO:0007165,GO:0007613,GO:0008542,GO:0048018" extracellular space|nucleus|cytoplasm|signal transduction|memory|visual learning|receptor ligand activity TAFA3 60.0363031 62.92727004 57.14533616 0.908117198 -0.139049597 0.881667371 1 2.098119969 1.987413097 284467 TAFA chemokine like family member 3 "GO:0005615,GO:0007165,GO:0014016,GO:0048018,GO:1902692,GO:1903979,GO:1903980" extracellular space|signal transduction|neuroblast differentiation|receptor ligand activity|regulation of neuroblast proliferation|negative regulation of microglial cell activation|positive regulation of microglial cell activation TAGLN 771.9734755 136.0040998 1407.942851 10.35220889 3.371866729 2.15E-16 9.72E-13 1.617311073 17.4639515 6876 transgelin "GO:0005515,GO:0005737,GO:0007517,GO:0030855,GO:0051015" protein binding|cytoplasm|muscle organ development|epithelial cell differentiation|actin filament binding TAGLN2 10933.04776 11556.28866 10309.80685 0.892138225 -0.16466084 0.6273422 1 329.5525069 306.6709916 8407 transgelin 2 "GO:0002576,GO:0005515,GO:0005576,GO:0005829,GO:0030855,GO:0031982,GO:0045296,GO:0070062" platelet degranulation|protein binding|extracellular region|cytosol|epithelial cell differentiation|vesicle|cadherin binding|extracellular exosome TAGLN3 62.45764842 26.38885518 98.52644165 3.733638348 1.90058219 0.019452384 0.604243048 1.025711758 3.994601973 29114 transgelin 3 "GO:0000122,GO:0005634,GO:0007417" negative regulation of transcription by RNA polymerase II|nucleus|central nervous system development TAL1 32.33285483 21.31407534 43.35163433 2.033943938 1.024279915 0.292904074 1 0.147068491 0.312014333 6886 "TAL bHLH transcription factor 1, erythroid differentiation factor" "GO:0000118,GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001085,GO:0001525,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006366,GO:0007626,GO:0019899,GO:0021527,GO:0030097,GO:0030218,GO:0030219,GO:0030220,GO:0030221,GO:0031334,GO:0033193,GO:0035162,GO:0035855,GO:0042127,GO:0042826,GO:0043249,GO:0045165,GO:0045647,GO:0045648,GO:0045799,GO:0045893,GO:0045931,GO:0045944,GO:0046983,GO:0051781,GO:0060018,GO:0060216,GO:0060217,GO:0060218,GO:0060375,GO:0061098,GO:0070888,GO:1902036,GO:2000036,GO:2000273" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|angiogenesis|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|locomotory behavior|enzyme binding|spinal cord association neuron differentiation|hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|platelet formation|basophil differentiation|positive regulation of protein-containing complex assembly|Lsd1/2 complex|embryonic hemopoiesis|megakaryocyte development|regulation of cell population proliferation|histone deacetylase binding|erythrocyte maturation|cell fate commitment|negative regulation of erythrocyte differentiation|positive regulation of erythrocyte differentiation|positive regulation of chromatin assembly or disassembly|positive regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|protein dimerization activity|positive regulation of cell division|astrocyte fate commitment|definitive hemopoiesis|hemangioblast cell differentiation|hematopoietic stem cell differentiation|regulation of mast cell differentiation|positive regulation of protein tyrosine kinase activity|E-box binding|regulation of hematopoietic stem cell differentiation|regulation of stem cell population maintenance|positive regulation of signaling receptor activity" bHLH TALDO1 3739.706204 3848.713032 3630.699375 0.943354141 -0.084128626 0.792130967 1 162.5719246 159.9691499 6888 transaldolase 1 "GO:0004801,GO:0005515,GO:0005622,GO:0005634,GO:0005737,GO:0005829,GO:0005975,GO:0005999,GO:0006002,GO:0006098,GO:0009052,GO:0019682,GO:0035722,GO:0048029,GO:0070062" "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity|protein binding|intracellular anatomical structure|nucleus|cytoplasm|cytosol|carbohydrate metabolic process|xylulose biosynthetic process|fructose 6-phosphate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|glyceraldehyde-3-phosphate metabolic process|interleukin-12-mediated signaling pathway|monosaccharide binding|extracellular exosome" hsa00030 Pentose phosphate pathway TAMALIN 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.031967624 0 160622 trafficking regulator and scaffold protein tamalin "GO:0005886,GO:0007165,GO:0008104,GO:0014069,GO:0030165,GO:0042802,GO:0045211,GO:0048471,GO:0098685,GO:0098978,GO:0099152" "plasma membrane|signal transduction|protein localization|postsynaptic density|PDZ domain binding|identical protein binding|postsynaptic membrane|perinuclear region of cytoplasm|Schaffer collateral - CA1 synapse|glutamatergic synapse|regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane" TAMM41 273.7184314 256.78386 290.6530029 1.131897475 0.178743288 0.718381687 1 2.425890063 2.864139301 132001 TAM41 mitochondrial translocator assembly and maintenance homolog "GO:0004605,GO:0005515,GO:0005743,GO:0016024,GO:0019898,GO:0031314,GO:0032049" phosphatidate cytidylyltransferase activity|protein binding|mitochondrial inner membrane|CDP-diacylglycerol biosynthetic process|extrinsic component of membrane|extrinsic component of mitochondrial inner membrane|cardiolipin biosynthetic process TANC1 630.4811436 532.8518834 728.1104038 1.366440518 0.45042266 0.244116701 1 3.127485005 4.457608237 85461 "tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1" "GO:0005515,GO:0007520,GO:0008542,GO:0014069,GO:0030425,GO:0043025,GO:0043679,GO:0097062" protein binding|myoblast fusion|visual learning|postsynaptic density|dendrite|neuronal cell body|axon terminus|dendritic spine maintenance TANC2 3069.956506 2854.056183 3285.856829 1.151293674 0.203255886 0.523058876 1 7.84562946 9.421712357 26115 "tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2" "GO:0001701,GO:0030424,GO:0043197,GO:0060998,GO:0061001,GO:0099519" in utero embryonic development|axon|dendritic spine|regulation of dendritic spine development|regulation of dendritic spine morphogenesis|dense core granule cytoskeletal transport TANGO2 602.1878237 585.6295938 618.7460536 1.056548474 0.079358959 0.842696092 1 10.09532776 11.12565991 128989 transport and golgi organization 2 homolog "GO:0005794,GO:0007030,GO:0009306" Golgi apparatus|Golgi organization|protein secretion TANGO6 334.3958245 329.8606897 338.9309593 1.027497273 0.039134566 0.938633631 1 3.133210851 3.35804282 79613 transport and golgi organization 6 homolog "GO:0009306,GO:0016021" protein secretion|integral component of membrane TANK 623.2725314 511.5378081 735.0072547 1.436858123 0.522917616 0.177482107 1 8.575830977 12.85304506 10010 TRAF family member associated NFKB activator "GO:0004843,GO:0005515,GO:0005829,GO:0006508,GO:0006974,GO:0007165,GO:0007249,GO:0016032,GO:0018215,GO:0031625,GO:0032991,GO:0035666,GO:0035800,GO:0043124,GO:0046872,GO:0071347,GO:0071356,GO:0071479,GO:1903003,GO:2000158" thiol-dependent ubiquitin-specific protease activity|protein binding|cytosol|proteolysis|cellular response to DNA damage stimulus|signal transduction|I-kappaB kinase/NF-kappaB signaling|viral process|protein phosphopantetheinylation|ubiquitin protein ligase binding|protein-containing complex|TRIF-dependent toll-like receptor signaling pathway|deubiquitinase activator activity|negative regulation of I-kappaB kinase/NF-kappaB signaling|metal ion binding|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to ionizing radiation|positive regulation of protein deubiquitination|positive regulation of ubiquitin-specific protease activity "hsa04140,hsa04621,hsa04622,hsa05014,hsa05022" Autophagy - animal|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases TAOK1 5505.154309 5825.847258 5184.46136 0.889906846 -0.16827377 0.602201322 1 23.33770555 21.66300169 57551 TAO kinase 1 "GO:0000165,GO:0000187,GO:0000226,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006281,GO:0006468,GO:0006974,GO:0007026,GO:0007095,GO:0007165,GO:0007257,GO:0015630,GO:0016301,GO:0016310,GO:0016740,GO:0031098,GO:0032147,GO:0032874,GO:0032956,GO:0043014,GO:0043539,GO:0046330,GO:0046777,GO:0048156,GO:0048471,GO:0048487,GO:0048812,GO:0050321,GO:0051493,GO:0070050,GO:0070062,GO:0070507,GO:0097194,GO:0106310,GO:0106311,GO:1901985" MAPK cascade|activation of MAPK activity|microtubule cytoskeleton organization|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|DNA repair|protein phosphorylation|cellular response to DNA damage stimulus|negative regulation of microtubule depolymerization|mitotic G2 DNA damage checkpoint|signal transduction|activation of JUN kinase activity|microtubule cytoskeleton|kinase activity|phosphorylation|transferase activity|stress-activated protein kinase signaling cascade|activation of protein kinase activity|positive regulation of stress-activated MAPK cascade|regulation of actin cytoskeleton organization|alpha-tubulin binding|protein serine/threonine kinase activator activity|positive regulation of JNK cascade|protein autophosphorylation|tau protein binding|perinuclear region of cytoplasm|beta-tubulin binding|neuron projection morphogenesis|tau-protein kinase activity|regulation of cytoskeleton organization|neuron cellular homeostasis|extracellular exosome|regulation of microtubule cytoskeleton organization|execution phase of apoptosis|protein serine kinase activity|protein threonine kinase activity|positive regulation of protein acetylation hsa04010 MAPK signaling pathway TAOK2 1571.765706 1466.611374 1676.920037 1.143397676 0.193327263 0.558174753 1 11.52679892 13.74744377 9344 TAO kinase 2 "GO:0000165,GO:0000186,GO:0000187,GO:0001558,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006612,GO:0006915,GO:0006974,GO:0007095,GO:0007165,GO:0007409,GO:0008360,GO:0015629,GO:0016021,GO:0016477,GO:0030036,GO:0030424,GO:0030659,GO:0031098,GO:0031410,GO:0031434,GO:0031954,GO:0032147,GO:0032874,GO:0032956,GO:0038191,GO:0043005,GO:0043235,GO:0044294,GO:0044295,GO:0046330,GO:0046777,GO:0048041,GO:0048156,GO:0048812,GO:0050321,GO:0051403,GO:0106310,GO:0106311,GO:0150019,GO:0150020" MAPK cascade|activation of MAPKK activity|activation of MAPK activity|regulation of cell growth|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|cytosol|protein targeting to membrane|apoptotic process|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|signal transduction|axonogenesis|regulation of cell shape|actin cytoskeleton|integral component of membrane|cell migration|actin cytoskeleton organization|axon|cytoplasmic vesicle membrane|stress-activated protein kinase signaling cascade|cytoplasmic vesicle|mitogen-activated protein kinase kinase binding|positive regulation of protein autophosphorylation|activation of protein kinase activity|positive regulation of stress-activated MAPK cascade|regulation of actin cytoskeleton organization|neuropilin binding|neuron projection|receptor complex|dendritic growth cone|axonal growth cone|positive regulation of JNK cascade|protein autophosphorylation|focal adhesion assembly|tau protein binding|neuron projection morphogenesis|tau-protein kinase activity|stress-activated MAPK cascade|protein serine kinase activity|protein threonine kinase activity|basal dendrite morphogenesis|basal dendrite arborization hsa04010 MAPK signaling pathway TAOK3 1110.802498 1206.782646 1014.822349 0.84093217 -0.249938659 0.470891513 1 9.804184114 8.599800067 51347 TAO kinase 3 "GO:0000165,GO:0004674,GO:0004860,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006281,GO:0006468,GO:0006469,GO:0006974,GO:0007095,GO:0007165,GO:0016740,GO:0031098,GO:0032147,GO:0032874,GO:0043507,GO:0046329,GO:0046330,GO:0046777,GO:0048812,GO:0106310,GO:0106311" MAPK cascade|protein serine/threonine kinase activity|protein kinase inhibitor activity|protein binding|ATP binding|cytoplasm|plasma membrane|DNA repair|protein phosphorylation|negative regulation of protein kinase activity|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|signal transduction|transferase activity|stress-activated protein kinase signaling cascade|activation of protein kinase activity|positive regulation of stress-activated MAPK cascade|positive regulation of JUN kinase activity|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation|neuron projection morphogenesis|protein serine kinase activity|protein threonine kinase activity hsa04010 MAPK signaling pathway TAP1 897.4484603 833.27885 961.6180705 1.154017134 0.206664645 0.566256981 1 14.79755755 17.81222713 6890 "transporter 1, ATP binding cassette subfamily B member" "GO:0002250,GO:0002474,GO:0002479,GO:0005515,GO:0005524,GO:0005783,GO:0005789,GO:0006952,GO:0015031,GO:0015433,GO:0015440,GO:0015833,GO:0016020,GO:0016021,GO:0016032,GO:0016887,GO:0019885,GO:0023029,GO:0030176,GO:0030670,GO:0033116,GO:0034451,GO:0042288,GO:0042605,GO:0042626,GO:0042803,GO:0042824,GO:0042825,GO:0043531,GO:0046967,GO:0046978,GO:0046979,GO:0055085,GO:0098656,GO:1904680,GO:1990668" "adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|defense response|protein transport|ATPase-coupled peptide antigen transmembrane transporter activity|ATPase-coupled peptide transmembrane transporter activity|peptide transport|membrane|integral component of membrane|viral process|ATPase activity|antigen processing and presentation of endogenous peptide antigen via MHC class I|MHC class Ib protein binding|integral component of endoplasmic reticulum membrane|phagocytic vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|centriolar satellite|MHC class I protein binding|peptide antigen binding|ATPase-coupled transmembrane transporter activity|protein homodimerization activity|MHC class I peptide loading complex|TAP complex|ADP binding|cytosol to endoplasmic reticulum transport|TAP1 binding|TAP2 binding|transmembrane transport|anion transmembrane transport|peptide transmembrane transporter activity|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane" "hsa02010,hsa04145,hsa04612,hsa05163,hsa05168,hsa05169,hsa05170,hsa05340" ABC transporters|Phagosome|Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Primary immunodeficiency TAP2 803.519012 844.4433657 762.5946584 0.903073775 -0.147084243 0.690547036 1 6.975709909 6.570941071 6891 "transporter 2, ATP binding cassette subfamily B member" "GO:0002250,GO:0002474,GO:0002479,GO:0002489,GO:0005515,GO:0005524,GO:0005783,GO:0005789,GO:0015031,GO:0015433,GO:0015440,GO:0015833,GO:0016020,GO:0016021,GO:0016032,GO:0016607,GO:0016887,GO:0019885,GO:0023029,GO:0030176,GO:0030670,GO:0033116,GO:0042288,GO:0042605,GO:0042626,GO:0042824,GO:0042825,GO:0046967,GO:0046968,GO:0046978,GO:0046980,GO:0055085,GO:0098656,GO:1904680,GO:1990668" "adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|protein binding|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein transport|ATPase-coupled peptide antigen transmembrane transporter activity|ATPase-coupled peptide transmembrane transporter activity|peptide transport|membrane|integral component of membrane|viral process|nuclear speck|ATPase activity|antigen processing and presentation of endogenous peptide antigen via MHC class I|MHC class Ib protein binding|integral component of endoplasmic reticulum membrane|phagocytic vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|MHC class I protein binding|peptide antigen binding|ATPase-coupled transmembrane transporter activity|MHC class I peptide loading complex|TAP complex|cytosol to endoplasmic reticulum transport|peptide antigen transport|TAP1 binding|tapasin binding|transmembrane transport|anion transmembrane transport|peptide transmembrane transporter activity|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane" "hsa02010,hsa04145,hsa04612,hsa05163,hsa05168,hsa05169,hsa05170,hsa05340" ABC transporters|Phagosome|Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Primary immunodeficiency TAPBP 2607.547815 2562.76382 2652.331809 1.034949763 0.049560741 0.877509484 1 34.16555583 36.88278355 6892 TAP binding protein "GO:0000139,GO:0002398,GO:0002474,GO:0002479,GO:0005515,GO:0005783,GO:0005789,GO:0006890,GO:0006955,GO:0010468,GO:0015433,GO:0015833,GO:0016021,GO:0019885,GO:0030670,GO:0033116,GO:0042288,GO:0042605,GO:0042824,GO:0046978,GO:0046979,GO:0050823,GO:0051082,GO:0061635,GO:0062061,GO:0065003,GO:0071556,GO:1990668" "Golgi membrane|MHC class Ib protein complex assembly|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|immune response|regulation of gene expression|ATPase-coupled peptide antigen transmembrane transporter activity|peptide transport|integral component of membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|phagocytic vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|MHC class I protein binding|peptide antigen binding|MHC class I peptide loading complex|TAP1 binding|TAP2 binding|peptide antigen stabilization|unfolded protein binding|regulation of protein complex stability|TAP complex binding|protein-containing complex assembly|integral component of lumenal side of endoplasmic reticulum membrane|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane" "hsa04612,hsa05163,hsa05168,hsa05169,hsa05170" Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection TAPBPL 262.5066569 264.9035077 260.109806 0.98190397 -0.026346158 0.96585624 1 4.608872602 4.720409213 55080 TAP binding protein like "GO:0000139,GO:0002502,GO:0002590,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0016021,GO:0023024" Golgi membrane|peptide antigen assembly with MHC class I protein complex|negative regulation of antigen processing and presentation of peptide antigen via MHC class I|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of membrane|MHC class I protein complex binding TAPT1 207.8002334 195.8865019 219.7139649 1.121639127 0.165608581 0.762313856 1 2.106360993 2.464347135 202018 transmembrane anterior posterior transformation 1 "GO:0001503,GO:0005813,GO:0007186,GO:0014032,GO:0016021,GO:0016032,GO:0016520,GO:0030030,GO:0030176,GO:0035437,GO:0036064,GO:0045724,GO:0048706,GO:0051216,GO:0061036,GO:1903012" ossification|centrosome|G protein-coupled receptor signaling pathway|neural crest cell development|integral component of membrane|viral process|growth hormone-releasing hormone receptor activity|cell projection organization|integral component of endoplasmic reticulum membrane|maintenance of protein localization in endoplasmic reticulum|ciliary basal body|positive regulation of cilium assembly|embryonic skeletal system development|cartilage development|positive regulation of cartilage development|positive regulation of bone development TARBP1 604.6549441 720.6187375 488.6911506 0.678154932 -0.560313185 0.151302276 1 6.875809508 4.863721401 6894 TAR (HIV-1) RNA binding protein 1 "GO:0003723,GO:0005634,GO:0006357,GO:0016423,GO:0030488" RNA binding|nucleus|regulation of transcription by RNA polymerase II|tRNA (guanine) methyltransferase activity|tRNA methylation TARBP2 578.3606068 606.9436691 549.7775444 0.90581313 -0.142714644 0.720204557 1 17.12510065 16.18034114 6895 TARBP2 subunit of RISC loading complex "GO:0003725,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006469,GO:0007286,GO:0007338,GO:0010586,GO:0016442,GO:0016604,GO:0019899,GO:0030422,GO:0030423,GO:0031054,GO:0035087,GO:0035196,GO:0035197,GO:0035198,GO:0035264,GO:0035280,GO:0036002,GO:0042802,GO:0042803,GO:0043403,GO:0045070,GO:0045727,GO:0046782,GO:0047485,GO:0048471,GO:0050689,GO:0051149,GO:0061351,GO:0070578,GO:0070883,GO:0090065,GO:1903798" double-stranded RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|negative regulation of protein kinase activity|spermatid development|single fertilization|miRNA metabolic process|RISC complex|nuclear body|enzyme binding|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|pre-miRNA processing|siRNA loading onto RISC involved in RNA interference|production of miRNAs involved in gene silencing by miRNA|siRNA binding|miRNA binding|multicellular organism growth|miRNA loading onto RISC involved in gene silencing by miRNA|pre-mRNA binding|identical protein binding|protein homodimerization activity|skeletal muscle tissue regeneration|positive regulation of viral genome replication|positive regulation of translation|regulation of viral transcription|protein N-terminus binding|perinuclear region of cytoplasm|negative regulation of defense response to virus by host|positive regulation of muscle cell differentiation|neural precursor cell proliferation|RISC-loading complex|pre-miRNA binding|regulation of production of siRNA involved in RNA interference|regulation of production of miRNAs involved in gene silencing by miRNA TARDBP 2900.870336 2778.949441 3022.79123 1.087746033 0.121341755 0.703539145 1 32.50438468 36.87953077 23435 TAR DNA binding protein "GO:0000978,GO:0001933,GO:0003690,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005726,GO:0006397,GO:0008380,GO:0010468,GO:0010494,GO:0010629,GO:0016607,GO:0031647,GO:0032024,GO:0034976,GO:0035061,GO:0042307,GO:0042752,GO:0042802,GO:0042981,GO:0043922,GO:0048511,GO:0051726,GO:0061158,GO:0070935,GO:0071765,GO:0097157" RNA polymerase II cis-regulatory region sequence-specific DNA binding|negative regulation of protein phosphorylation|double-stranded DNA binding|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|perichromatin fibrils|mRNA processing|RNA splicing|regulation of gene expression|cytoplasmic stress granule|negative regulation of gene expression|nuclear speck|regulation of protein stability|positive regulation of insulin secretion|response to endoplasmic reticulum stress|interchromatin granule|positive regulation of protein import into nucleus|regulation of circadian rhythm|identical protein binding|regulation of apoptotic process|negative regulation by host of viral transcription|rhythmic process|regulation of cell cycle|3'-UTR-mediated mRNA destabilization|3'-UTR-mediated mRNA stabilization|nuclear inner membrane organization|pre-mRNA intronic binding "hsa03013,hsa03015,hsa05014,hsa05022" RNA transport|mRNA surveillance pathway|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases TARS1 4227.031297 4125.796011 4328.266582 1.049074305 0.069116866 0.829088113 1 72.88350647 79.75380979 6897 threonyl-tRNA synthetase 1 "GO:0000049,GO:0004829,GO:0005515,GO:0005524,GO:0005829,GO:0006418,GO:0006435,GO:0008270,GO:0042802,GO:0070062" tRNA binding|threonine-tRNA ligase activity|protein binding|ATP binding|cytosol|tRNA aminoacylation for protein translation|threonyl-tRNA aminoacylation|zinc ion binding|identical protein binding|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis TARS2 1051.871709 949.9987864 1153.744632 1.214469585 0.28032636 0.422737031 1 17.59198798 22.28524907 80222 "threonyl-tRNA synthetase 2, mitochondrial" "GO:0002161,GO:0004829,GO:0005515,GO:0005524,GO:0005575,GO:0005759,GO:0006435,GO:0042803,GO:0070159,GO:0106074" aminoacyl-tRNA editing activity|threonine-tRNA ligase activity|protein binding|ATP binding|cellular_component|mitochondrial matrix|threonyl-tRNA aminoacylation|protein homodimerization activity|mitochondrial threonyl-tRNA aminoacylation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis TARS3 238.0262258 241.5595205 234.4929311 0.970745971 -0.042834281 0.941644657 1 2.618608207 2.65150256 123283 threonyl-tRNA synthetase 3 "GO:0003674,GO:0004829,GO:0005515,GO:0005524,GO:0005575,GO:0005634,GO:0005737,GO:0006435,GO:0008150" molecular_function|threonine-tRNA ligase activity|protein binding|ATP binding|cellular_component|nucleus|cytoplasm|threonyl-tRNA aminoacylation|biological_process hsa00970 Aminoacyl-tRNA biosynthesis TAS1R1 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.036689143 80835 taste 1 receptor member 1 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0008527,GO:0016021,GO:0050912,GO:0050917" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|taste receptor activity|integral component of membrane|detection of chemical stimulus involved in sensory perception of taste|sensory perception of umami taste hsa04742 Taste transduction TAS2R10 7.075000227 12.17947162 1.970528833 0.161790995 -2.627796782 0.131724939 1 0.667583627 0.11266161 50839 taste 2 receptor member 10 "GO:0001580,GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0008527,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R14 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.161647608 0.109118792 50840 taste 2 receptor member 14 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0008527,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R19 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.15390401 0.207783089 259294 taste 2 receptor member 19 "GO:0001580,GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R20 15.97207153 14.20938356 17.7347595 1.248101962 0.319735798 0.833790251 1 0.307020115 0.399698783 259295 taste 2 receptor member 20 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R3 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.14006523 0 50831 taste 2 receptor member 3 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0008527,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R31 5.508028946 6.08973581 4.926322083 0.808954975 -0.305868687 0.976518791 1 0.302079956 0.254895513 259290 taste 2 receptor member 31 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R38 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.224864126 0 5726 taste 2 receptor member 38 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R4 9.449086613 6.08973581 12.80843742 2.103282936 1.072642936 0.477702664 1 0.061463459 0.134843688 50832 taste 2 receptor member 4 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0007585,GO:0008527,GO:0016021,GO:0033038,GO:0060170" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|respiratory gaseous exchange by respiratory system|taste receptor activity|integral component of membrane|bitter taste receptor activity|ciliary membrane hsa04742 Taste transduction TAS2R5 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.133980728 0.135663763 54429 taste 2 receptor member 5 "GO:0001580,GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0007635,GO:0008527,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|chemosensory behavior|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TASOR 3403.114688 3166.662621 3639.566755 1.149338338 0.200803556 0.528037848 1 19.84904585 23.79597249 23272 transcription activation suppressor "GO:0000792,GO:0001701,GO:0003682,GO:0003723,GO:0005515,GO:0005654,GO:0008595,GO:0045814,GO:0045869,GO:0060809,GO:0090307,GO:0090309,GO:0097355" "heterochromatin|in utero embryonic development|chromatin binding|RNA binding|protein binding|nucleoplasm|anterior/posterior axis specification, embryo|negative regulation of gene expression, epigenetic|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|mesodermal to mesenchymal transition involved in gastrulation|mitotic spindle assembly|positive regulation of DNA methylation-dependent heterochromatin assembly|protein localization to heterochromatin" TASOR2 1997.850258 2170.990816 1824.709699 0.840496277 -0.250686665 0.436856083 1 6.582042865 5.770486512 54906 transcription activation suppressor family member 2 "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol TASP1 231.5801914 205.0211056 258.1392771 1.259086358 0.332377238 0.520486183 1 3.449699577 4.530568735 55617 taspase 1 "GO:0004298,GO:0005737,GO:0006508,GO:0042802,GO:0045893,GO:0051604" "threonine-type endopeptidase activity|cytoplasm|proteolysis|identical protein binding|positive regulation of transcription, DNA-templated|protein maturation" TATDN1 490.0661185 531.8369274 448.2953095 0.842918734 -0.246534548 0.55002103 1 20.43677099 17.96858648 83940 TatD DNase domain containing 1 "GO:0005515,GO:0005654,GO:0006259,GO:0008296,GO:0016888,GO:0046872,GO:0090305" "protein binding|nucleoplasm|DNA metabolic process|3'-5'-exodeoxyribonuclease activity|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|nucleic acid phosphodiester bond hydrolysis" TATDN2 2331.409522 2140.542137 2522.276906 1.178335555 0.236750434 0.459128694 1 21.95886325 26.98949546 9797 TatD DNase domain containing 2 "GO:0005654,GO:0006259,GO:0016888,GO:0036498,GO:0046872,GO:0090305" "nucleoplasm|DNA metabolic process|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|IRE1-mediated unfolded protein response|metal ion binding|nucleic acid phosphodiester bond hydrolysis" TATDN3 203.5595386 209.0809295 198.0381477 0.947184175 -0.078283117 0.892692199 1 3.968969822 3.921282761 128387 TatD DNase domain containing 3 "GO:0004518,GO:0005634,GO:0046872,GO:0090305" nuclease activity|nucleus|metal ion binding|nucleic acid phosphodiester bond hydrolysis TAX1BP1 2406.737712 2137.497269 2675.978155 1.251921204 0.324143762 0.3102448 1 31.15300606 40.68111845 8887 Tax1 binding protein 1 "GO:0005515,GO:0005829,GO:0006915,GO:0010803,GO:0019900,GO:0032088,GO:0032480,GO:0043066,GO:0046872,GO:0070062" protein binding|cytosol|apoptotic process|regulation of tumor necrosis factor-mediated signaling pathway|kinase binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of apoptotic process|metal ion binding|extracellular exosome hsa04137 Mitophagy - animal TAX1BP3 2687.559598 2240.007822 3135.111373 1.399598404 0.485012925 0.128335543 1 88.63163588 129.3922109 30851 Tax1 binding protein 3 "GO:0001650,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007266,GO:0008013,GO:0008022,GO:0008285,GO:0015629,GO:0016055,GO:0030178,GO:0043231,GO:0070062,GO:0090630,GO:2000009" fibrillar center|protein binding|cytoplasm|cytosol|plasma membrane|Rho protein signal transduction|beta-catenin binding|protein C-terminus binding|negative regulation of cell population proliferation|actin cytoskeleton|Wnt signaling pathway|negative regulation of Wnt signaling pathway|intracellular membrane-bounded organelle|extracellular exosome|activation of GTPase activity|negative regulation of protein localization to cell surface TAZ 610.5922628 587.6595057 633.5250198 1.07804777 0.108421108 0.783848627 1 10.71377999 12.04749236 6901 tafazzin "GO:0003841,GO:0005739,GO:0005743,GO:0006936,GO:0007007,GO:0007507,GO:0007519,GO:0008374,GO:0016021,GO:0030097,GO:0031966,GO:0032049,GO:0032981,GO:0035965,GO:0042407,GO:0042775,GO:0047184,GO:0048738,GO:0060048" 1-acylglycerol-3-phosphate O-acyltransferase activity|mitochondrion|mitochondrial inner membrane|muscle contraction|inner mitochondrial membrane organization|heart development|skeletal muscle tissue development|O-acyltransferase activity|integral component of membrane|hemopoiesis|mitochondrial membrane|cardiolipin biosynthetic process|mitochondrial respiratory chain complex I assembly|cardiolipin acyl-chain remodeling|cristae formation|mitochondrial ATP synthesis coupled electron transport|1-acylglycerophosphocholine O-acyltransferase activity|cardiac muscle tissue development|cardiac muscle contraction hsa00564 Glycerophospholipid metabolism other TBC1D1 1539.693394 1362.07091 1717.315878 1.260812389 0.334353617 0.311807479 1 8.795624949 11.56732932 23216 TBC1 domain family member 1 "GO:0005096,GO:0005515,GO:0005634,GO:0005829,GO:0006886,GO:0032880,GO:0061024,GO:0090630,GO:1902017" GTPase activator activity|protein binding|nucleus|cytosol|intracellular protein transport|regulation of protein localization|membrane organization|activation of GTPase activity|regulation of cilium assembly hsa04152 AMPK signaling pathway TBC1D10A 397.5984833 373.5037964 421.6931703 1.12901977 0.175070749 0.690377624 1 9.49154523 11.17775016 83874 TBC1 domain family member 10A "GO:0005085,GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0005902,GO:0006886,GO:0030165,GO:0042147,GO:0045296,GO:0045862,GO:0070062,GO:0090630,GO:0097202,GO:1902017" "guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytosol|plasma membrane|microvillus|intracellular protein transport|PDZ domain binding|retrograde transport, endosome to Golgi|cadherin binding|positive regulation of proteolysis|extracellular exosome|activation of GTPase activity|activation of cysteine-type endopeptidase activity|regulation of cilium assembly" TBC1D10B 1032.634805 880.9817805 1184.287829 1.344281862 0.426835667 0.223401307 1 12.58990386 17.65341303 26000 TBC1 domain family member 10B "GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0042147,GO:0043087,GO:0090630,GO:1902017" "GTPase activator activity|protein binding|cytosol|plasma membrane|intracellular protein transport|retrograde transport, endosome to Golgi|regulation of GTPase activity|activation of GTPase activity|regulation of cilium assembly" TBC1D12 738.6563479 653.6316436 823.6810522 1.260160918 0.333607973 0.372059064 1 5.789460804 7.609919353 23232 TBC1 domain family member 12 "GO:0005096,GO:0005776,GO:0006886,GO:0055037,GO:0090630,GO:2000785" GTPase activator activity|autophagosome|intracellular protein transport|recycling endosome|activation of GTPase activity|regulation of autophagosome assembly TBC1D13 1262.479278 1135.735729 1389.222827 1.223191974 0.290650845 0.39211297 1 14.91340628 19.02774846 54662 TBC1 domain family member 13 "GO:0005096,GO:0005515,GO:0005829,GO:0006886,GO:0016020,GO:0090630,GO:1902017" GTPase activator activity|protein binding|cytosol|intracellular protein transport|membrane|activation of GTPase activity|regulation of cilium assembly TBC1D14 1546.394528 1382.370029 1710.419027 1.237309108 0.307205963 0.352503604 1 11.67647853 15.0697492 57533 TBC1 domain family member 14 "GO:0005096,GO:0005515,GO:0005654,GO:0005776,GO:0005794,GO:0005829,GO:0006886,GO:0006914,GO:0010507,GO:0019901,GO:0043231,GO:0055037,GO:0071955,GO:0090630,GO:1902017,GO:2000785" GTPase activator activity|protein binding|nucleoplasm|autophagosome|Golgi apparatus|cytosol|intracellular protein transport|autophagy|negative regulation of autophagy|protein kinase binding|intracellular membrane-bounded organelle|recycling endosome|recycling endosome to Golgi transport|activation of GTPase activity|regulation of cilium assembly|regulation of autophagosome assembly TBC1D15 944.6790476 862.7125731 1026.645522 1.190020354 0.25098625 0.48139577 1 11.65466747 14.46672435 64786 TBC1 domain family member 15 "GO:0005096,GO:0005515,GO:0005576,GO:0005737,GO:0006886,GO:0043087,GO:0090630,GO:1902017" GTPase activator activity|protein binding|extracellular region|cytoplasm|intracellular protein transport|regulation of GTPase activity|activation of GTPase activity|regulation of cilium assembly hsa04137 Mitophagy - animal TBC1D16 1111.473279 1218.962118 1003.98444 0.823638754 -0.279916381 0.419148033 1 4.720248569 4.055249432 125058 TBC1 domain family member 16 "GO:0001919,GO:0005096,GO:0005515,GO:0005769,GO:0005829,GO:0006886,GO:0090630,GO:1902017" regulation of receptor recycling|GTPase activator activity|protein binding|early endosome|cytosol|intracellular protein transport|activation of GTPase activity|regulation of cilium assembly TBC1D17 617.0140489 555.1809147 678.847183 1.222749495 0.290128869 0.456005861 1 9.732763852 12.41336736 79735 TBC1 domain family member 17 "GO:0005096,GO:0005515,GO:0005776,GO:0005829,GO:0006886,GO:0006914,GO:0042147,GO:0055037,GO:0090630,GO:1902017" "GTPase activator activity|protein binding|autophagosome|cytosol|intracellular protein transport|autophagy|retrograde transport, endosome to Golgi|recycling endosome|activation of GTPase activity|regulation of cilium assembly" hsa04137 Mitophagy - animal TBC1D19 170.2144494 152.2433953 188.1855036 1.236083202 0.305775856 0.594996528 1 1.403712159 1.809846308 55296 TBC1 domain family member 19 "GO:0005096,GO:0005515,GO:0043547,GO:1902017" GTPase activator activity|protein binding|positive regulation of GTPase activity|regulation of cilium assembly TBC1D2 554.4376342 520.6724118 588.2028567 1.129698527 0.175937824 0.661136332 1 4.029063535 4.747692778 55357 TBC1 domain family member 2 "GO:0005096,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006886,GO:0030054,GO:0031410,GO:0043547,GO:0045296,GO:0090630,GO:1902017" GTPase activator activity|protein binding|nucleoplasm|cytosol|plasma membrane|intracellular protein transport|cell junction|cytoplasmic vesicle|positive regulation of GTPase activity|cadherin binding|activation of GTPase activity|regulation of cilium assembly TBC1D20 2124.684865 2119.228062 2130.141669 1.005149803 0.00741053 0.983221651 1 30.9134289 32.41110972 128637 TBC1 domain family member 20 "GO:0005096,GO:0005515,GO:0005783,GO:0005789,GO:0006888,GO:0007030,GO:0019068,GO:0030173,GO:0031267,GO:0031965,GO:0033116,GO:0043547,GO:0044829,GO:0046726,GO:0048208,GO:0090110,GO:1902017,GO:1902953" GTPase activator activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|virion assembly|integral component of Golgi membrane|small GTPase binding|nuclear membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|positive regulation of GTPase activity|positive regulation by host of viral genome replication|positive regulation by virus of viral protein levels in host cell|COPII vesicle coating|COPII-coated vesicle cargo loading|regulation of cilium assembly|positive regulation of ER to Golgi vesicle-mediated transport TBC1D22A 746.8838755 811.9647747 681.8029763 0.839695264 -0.252062243 0.499575731 1 3.886876314 3.404382541 25771 TBC1 domain family member 22A "GO:0005096,GO:0005515,GO:0006886,GO:0042803,GO:0071889,GO:0090630,GO:1902017" GTPase activator activity|protein binding|intracellular protein transport|protein homodimerization activity|14-3-3 protein binding|activation of GTPase activity|regulation of cilium assembly TBC1D22B 365.102325 341.0252054 389.1794445 1.14120434 0.190557139 0.672159316 1 4.484997036 5.338773608 55633 TBC1 domain family member 22B "GO:0005096,GO:0005515,GO:0006886,GO:0071889,GO:0090630,GO:1902017" GTPase activator activity|protein binding|intracellular protein transport|14-3-3 protein binding|activation of GTPase activity|regulation of cilium assembly TBC1D23 1011.567664 922.5949753 1100.540353 1.192874861 0.254442705 0.469953439 1 12.24801593 15.23970494 55773 TBC1 domain family member 23 "GO:0005515,GO:0005794,GO:0005802,GO:0005829,GO:0007420,GO:0016192,GO:0031175,GO:0031410,GO:0042147,GO:0071203,GO:0099041,GO:1990403" "protein binding|Golgi apparatus|trans-Golgi network|cytosol|brain development|vesicle-mediated transport|neuron projection development|cytoplasmic vesicle|retrograde transport, endosome to Golgi|WASH complex|vesicle tethering to Golgi|embryonic brain development" TBC1D24 359.4755298 326.8158218 392.1352378 1.199866137 0.262873461 0.55910889 1 2.438071651 3.051372243 57465 TBC1 domain family member 24 "GO:0005096,GO:0005515,GO:0005737,GO:0005886,GO:0030054,GO:0030659,GO:0031175,GO:0031594,GO:0036475,GO:0043195,GO:0043547,GO:1902017" GTPase activator activity|protein binding|cytoplasm|plasma membrane|cell junction|cytoplasmic vesicle membrane|neuron projection development|neuromuscular junction|neuron death in response to oxidative stress|terminal bouton|positive regulation of GTPase activity|regulation of cilium assembly TBC1D25 706.3383389 633.3325243 779.3441535 1.230544972 0.299297384 0.427864925 1 8.368395015 10.74126898 4943 TBC1 domain family member 25 "GO:0005096,GO:0005515,GO:0005776,GO:0006886,GO:0006914,GO:0031410,GO:0090630,GO:1901096" GTPase activator activity|protein binding|autophagosome|intracellular protein transport|autophagy|cytoplasmic vesicle|activation of GTPase activity|regulation of autophagosome maturation TBC1D2B 3088.503824 2774.889618 3402.11803 1.226037248 0.29400281 0.355476412 1 22.50774662 28.78403087 23102 TBC1 domain family member 2B "GO:0005096,GO:0005515,GO:0005829,GO:0006886,GO:0090630,GO:1902017" GTPase activator activity|protein binding|cytosol|intracellular protein transport|activation of GTPase activity|regulation of cilium assembly TBC1D30 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.028456565 0.011525612 23329 TBC1 domain family member 30 "GO:0005096,GO:0005829,GO:0005886,GO:0005929,GO:0006886,GO:0031267,GO:0036064,GO:0043547,GO:0090630,GO:1902018" GTPase activator activity|cytosol|plasma membrane|cilium|intracellular protein transport|small GTPase binding|ciliary basal body|positive regulation of GTPase activity|activation of GTPase activity|negative regulation of cilium assembly TBC1D31 747.0580654 689.1551025 804.9610283 1.168040439 0.224090223 0.548684212 1 8.145455017 9.924054901 93594 TBC1 domain family member 31 GO:0005813 centrosome TBC1D32 85.93252607 115.7049804 56.16007174 0.485372985 -1.042834281 0.144791869 1 0.500644944 0.253466966 221322 TBC1 domain family member 32 "GO:0001822,GO:0002088,GO:0003406,GO:0005515,GO:0005737,GO:0005929,GO:0007368,GO:0007507,GO:0042733,GO:0060021,GO:0060831,GO:0061512,GO:1905515" kidney development|lens development in camera-type eye|retinal pigment epithelium development|protein binding|cytoplasm|cilium|determination of left/right symmetry|heart development|embryonic digit morphogenesis|roof of mouth development|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|protein localization to cilium|non-motile cilium assembly TBC1D3B 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.114843475 0 414059 TBC1 domain family member 3B "GO:0005096,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D3C 6.971079795 5.074779842 8.867379749 1.747342747 0.805162625 0.671092798 1 0.069747543 0.127122652 414060 TBC1 domain family member 3C "GO:0005096,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D3E 5.985815379 5.074779842 6.896850916 1.359044359 0.442592546 0.890504047 1 0.100319944 0.142212196 102723859 TBC1 domain family member 3E "GO:0005096,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D3F 5.000550962 5.074779842 4.926322083 0.970745971 -0.042834281 1 1 0.123745641 0.125300105 84218 TBC1 domain family member 3F "GO:0005096,GO:0005515,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|protein binding|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D3G 2.029911937 4.059823873 0 0 #NAME? 0.251078011 1 0.052857521 0 101060321 TBC1 domain family member 3G "GO:0005096,GO:0005515,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|protein binding|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D3H 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.040689134 0 729877 TBC1 domain family member 3H "GO:0005096,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D3I 14.01638847 15.22433953 12.80843742 0.841313174 -0.249285159 0.896625813 1 0.200327121 0.175797773 102724862 TBC1 domain family member 3I "GO:0005096,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D4 545.0721791 587.6595057 502.4848524 0.855061218 -0.225900382 0.573964516 1 2.588977107 2.309092597 9882 TBC1 domain family member 4 "GO:0005096,GO:0005515,GO:0005829,GO:0006886,GO:0016192,GO:0031339,GO:0031982,GO:0032869,GO:0090630" GTPase activator activity|protein binding|cytosol|intracellular protein transport|vesicle-mediated transport|negative regulation of vesicle fusion|vesicle|cellular response to insulin stimulus|activation of GTPase activity "hsa04919,hsa04931" Thyroid hormone signaling pathway|Insulin resistance TBC1D5 2433.863413 2308.009872 2559.716954 1.109058061 0.149334895 0.640481621 1 12.565039 14.53563649 9779 TBC1 domain family member 5 "GO:0002092,GO:0005096,GO:0005515,GO:0005776,GO:0005794,GO:0005829,GO:0006886,GO:0006914,GO:0010008,GO:0016236,GO:0030122,GO:0030904,GO:0035612,GO:0042147,GO:0042594,GO:0043231,GO:0044877,GO:0090630,GO:1902017,GO:1905394,GO:1990316" "positive regulation of receptor internalization|GTPase activator activity|protein binding|autophagosome|Golgi apparatus|cytosol|intracellular protein transport|autophagy|endosome membrane|macroautophagy|AP-2 adaptor complex|retromer complex|AP-2 adaptor complex binding|retrograde transport, endosome to Golgi|response to starvation|intracellular membrane-bounded organelle|protein-containing complex binding|activation of GTPase activity|regulation of cilium assembly|retromer complex binding|Atg1/ULK1 kinase complex" TBC1D7 6.522984915 8.119647747 4.926322083 0.606716232 -0.720906186 0.726457076 1 0.118305959 0.074870057 51256 TBC1 domain family member 7 "GO:0005096,GO:0005515,GO:0005829,GO:0031267,GO:0031398,GO:0031410,GO:0032007,GO:0036064,GO:0043547,GO:0070848,GO:0090630,GO:1902018" GTPase activator activity|protein binding|cytosol|small GTPase binding|positive regulation of protein ubiquitination|cytoplasmic vesicle|negative regulation of TOR signaling|ciliary basal body|positive regulation of GTPase activity|response to growth factor|activation of GTPase activity|negative regulation of cilium assembly hsa04150 mTOR signaling pathway TBC1D8 798.0352314 907.3706357 688.6998272 0.759006078 -0.397816657 0.279249317 1 7.345767533 5.815651364 11138 TBC1 domain family member 8 "GO:0005096,GO:0005515,GO:0006886,GO:0008015,GO:0008284,GO:0016020,GO:0090630,GO:1902017" GTPase activator activity|protein binding|intracellular protein transport|blood circulation|positive regulation of cell population proliferation|membrane|activation of GTPase activity|regulation of cilium assembly TBC1D8B 158.0119672 227.3501369 88.67379749 0.390031863 -1.358336107 0.021108925 0.628813993 1.822488508 0.741448201 54885 TBC1 domain family member 8B "GO:0003094,GO:0005096,GO:0005509,GO:0005515,GO:0005829,GO:0006886,GO:0016192,GO:0090630" glomerular filtration|GTPase activator activity|calcium ion binding|protein binding|cytosol|intracellular protein transport|vesicle-mediated transport|activation of GTPase activity TBC1D9 724.3376007 685.0952787 763.5799228 1.114560188 0.156474527 0.678487894 1 6.24732787 7.262961716 23158 TBC1 domain family member 9 "GO:0005096,GO:0005509,GO:0005515,GO:0006886,GO:0090630" GTPase activator activity|calcium ion binding|protein binding|intracellular protein transport|activation of GTPase activity TBC1D9B 3847.310341 4199.887797 3494.732885 0.832101488 -0.265168596 0.405191099 1 40.85852874 35.46295758 23061 TBC1 domain family member 9B "GO:0005096,GO:0005509,GO:0005515,GO:0006886,GO:0016021,GO:0090630,GO:1902017" GTPase activator activity|calcium ion binding|protein binding|intracellular protein transport|integral component of membrane|activation of GTPase activity|regulation of cilium assembly TBCA 978.5207283 1054.539251 902.5022056 0.855826091 -0.224610432 0.526230678 1 21.99699048 19.63652881 6902 tubulin folding cofactor A "GO:0003723,GO:0005515,GO:0005730,GO:0005737,GO:0005829,GO:0005874,GO:0006457,GO:0007021,GO:0007023,GO:0015630,GO:0015631,GO:0048487,GO:0051087" RNA binding|protein binding|nucleolus|cytoplasm|cytosol|microtubule|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|microtubule cytoskeleton|tubulin binding|beta-tubulin binding|chaperone binding TBCB 1240.530794 1184.453615 1296.607972 1.094688687 0.130520647 0.702688347 1 52.34589625 59.77081801 1155 tubulin folding cofactor B "GO:0005515,GO:0005737,GO:0005829,GO:0005874,GO:0007399,GO:0015630,GO:0030154" protein binding|cytoplasm|cytosol|microtubule|nervous system development|microtubule cytoskeleton|cell differentiation TBCC 267.9849943 268.9633316 267.0066569 0.992725125 -0.010533789 0.991508266 1 8.48197005 8.782975632 6903 tubulin folding cofactor C "GO:0000902,GO:0003924,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005874,GO:0006457,GO:0007021,GO:0007023,GO:0015631,GO:0032391,GO:0051087" cell morphogenesis|GTPase activity|protein binding|cytoplasm|cytosol|cytoskeleton|microtubule|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|tubulin binding|photoreceptor connecting cilium|chaperone binding TBCCD1 274.4310287 305.5017465 243.3603109 0.796592208 -0.328086726 0.502151708 1 5.313387951 4.414926832 55171 TBCC domain containing 1 "GO:0000902,GO:0005515,GO:0005737,GO:0008360,GO:0030334,GO:0031616,GO:0051661,GO:0051684" cell morphogenesis|protein binding|cytoplasm|regulation of cell shape|regulation of cell migration|spindle pole centrosome|maintenance of centrosome location|maintenance of Golgi location TBCD 1686.133328 1438.192607 1934.07405 1.344794877 0.427386133 0.191596417 1 6.103517841 8.561545991 6904 tubulin folding cofactor D "GO:0000226,GO:0000278,GO:0005096,GO:0005515,GO:0005737,GO:0005813,GO:0005874,GO:0005912,GO:0005923,GO:0006457,GO:0007021,GO:0007023,GO:0010812,GO:0016328,GO:0031115,GO:0034333,GO:0043547,GO:0048487,GO:0048667,GO:0051087,GO:0070830" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activator activity|protein binding|cytoplasm|centrosome|microtubule|adherens junction|bicellular tight junction|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|negative regulation of cell-substrate adhesion|lateral plasma membrane|negative regulation of microtubule polymerization|adherens junction assembly|positive regulation of GTPase activity|beta-tubulin binding|cell morphogenesis involved in neuron differentiation|chaperone binding|bicellular tight junction assembly TBCE 348.3622324 409.0272553 287.6972096 0.703369289 -0.507645751 0.261239975 1 3.710511825 2.72228225 6905 tubulin folding cofactor E "GO:0000226,GO:0005515,GO:0005737,GO:0005874,GO:0006457,GO:0007021,GO:0007023,GO:0007052,GO:0043014,GO:0051087" microtubule cytoskeleton organization|protein binding|cytoplasm|microtubule|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|mitotic spindle organization|alpha-tubulin binding|chaperone binding TBCEL 411.8699716 372.4888404 451.2511028 1.21144865 0.276733254 0.521734179 1 3.675286519 4.644213126 219899 tubulin folding cofactor E like "GO:0000226,GO:0005515,GO:0005737,GO:0005856,GO:0007021,GO:0007023,GO:0043014" microtubule cytoskeleton organization|protein binding|cytoplasm|cytoskeleton|tubulin complex assembly|post-chaperonin tubulin folding pathway|alpha-tubulin binding TBCEL-TECTA 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.018577499 0 116804918 TBCEL-TECTA readthrough TBCK 223.1163692 198.9313698 247.3013686 1.243149177 0.313999429 0.549221702 1 1.104612662 1.432350136 93627 TBC1 domain containing kinase "GO:0004672,GO:0005096,GO:0005524,GO:0005737,GO:0006468,GO:0006886,GO:0008283,GO:0030036,GO:0030496,GO:0032006,GO:0072686,GO:0090630" protein kinase activity|GTPase activator activity|ATP binding|cytoplasm|protein phosphorylation|intracellular protein transport|cell population proliferation|actin cytoskeleton organization|midbody|regulation of TOR signaling|mitotic spindle|activation of GTPase activity TBK1 1006.07844 1052.509339 959.6475417 0.911771047 -0.133256498 0.706673282 1 15.60476727 14.84085845 29110 TANK binding kinase 1 "GO:0002218,GO:0003676,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006954,GO:0007249,GO:0009615,GO:0010008,GO:0016032,GO:0016239,GO:0018105,GO:0018107,GO:0019903,GO:0032479,GO:0032480,GO:0032481,GO:0032606,GO:0032727,GO:0032728,GO:0033138,GO:0035666,GO:0042802,GO:0043123,GO:0043231,GO:0044565,GO:0045087,GO:0045944,GO:0050830,GO:0051219,GO:0051607,GO:0060340,GO:0071345,GO:0106310,GO:0106311,GO:1901214,GO:1904417" activation of innate immune response|nucleic acid binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|inflammatory response|I-kappaB kinase/NF-kappaB signaling|response to virus|endosome membrane|viral process|positive regulation of macroautophagy|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein phosphatase binding|regulation of type I interferon production|negative regulation of type I interferon production|positive regulation of type I interferon production|type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of peptidyl-serine phosphorylation|TRIF-dependent toll-like receptor signaling pathway|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|dendritic cell proliferation|innate immune response|positive regulation of transcription by RNA polymerase II|defense response to Gram-positive bacterium|phosphoprotein binding|defense response to virus|positive regulation of type I interferon-mediated signaling pathway|cellular response to cytokine stimulus|protein serine kinase activity|protein threonine kinase activity|regulation of neuron death|positive regulation of xenophagy "hsa04014,hsa04137,hsa04140,hsa04620,hsa04621,hsa04622,hsa04623,hsa04657,hsa05014,hsa05022,hsa05131,hsa05135,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171" Ras signaling pathway|Mitophagy - animal|Autophagy - animal|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|IL-17 signaling pathway|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Yersinia infection|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 TBKBP1 307.5979686 350.1598091 265.0361281 0.756900481 -0.40182447 0.392757427 1 3.415050846 2.69619864 9755 TBK1 binding protein 1 "GO:0005515,GO:0005737,GO:0007249,GO:0016032,GO:0045087,GO:0046872" protein binding|cytoplasm|I-kappaB kinase/NF-kappaB signaling|viral process|innate immune response|metal ion binding hsa04622 RIG-I-like receptor signaling pathway TBL1X 796.9757381 902.2958559 691.6556204 0.766550811 -0.38354667 0.297008897 1 7.465790229 5.969427205 6907 transducin beta like 1 X-linked "GO:0000118,GO:0000122,GO:0000976,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006508,GO:0007605,GO:0008013,GO:0008022,GO:0008134,GO:0016575,GO:0017053,GO:0019216,GO:0019904,GO:0042393,GO:0043161,GO:0045893,GO:0045944,GO:0050821,GO:0072686,GO:0090263" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|proteolysis|sensory perception of sound|beta-catenin binding|protein C-terminus binding|transcription factor binding|histone deacetylation|transcription repressor complex|regulation of lipid metabolic process|protein domain specific binding|histone binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein stabilization|mitotic spindle|positive regulation of canonical Wnt signaling pathway" hsa04310 Wnt signaling pathway other TBL1XR1 2102.339504 2275.531281 1929.147728 0.847779041 -0.238239794 0.458501075 1 13.21344093 11.68461838 79718 TBL1X receptor 1 "GO:0000118,GO:0000122,GO:0000976,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008013,GO:0016575,GO:0017053,GO:0019216,GO:0042393,GO:0043161,GO:0045893,GO:0045944,GO:0047485,GO:0072686,GO:0090263" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|beta-catenin binding|histone deacetylation|transcription repressor complex|regulation of lipid metabolic process|histone binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|mitotic spindle|positive regulation of canonical Wnt signaling pathway" hsa04310 Wnt signaling pathway other TBL2 1184.501612 1227.081766 1141.921459 0.930599322 -0.103767959 0.763766229 1 12.68572414 12.31385185 26608 transducin beta like 2 "GO:0003723,GO:0005783,GO:0019901,GO:0030176,GO:0030968,GO:0031369,GO:0042149,GO:0051219,GO:0071456" RNA binding|endoplasmic reticulum|protein kinase binding|integral component of endoplasmic reticulum membrane|endoplasmic reticulum unfolded protein response|translation initiation factor binding|cellular response to glucose starvation|phosphoprotein binding|cellular response to hypoxia TBL3 895.5912545 908.3855917 882.7969172 0.971830603 -0.041223231 0.911761458 1 6.782622089 6.875497373 10607 transducin beta like 3 "GO:0000472,GO:0000480,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030686,GO:0032040,GO:0034511" "endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|90S preribosome|small-subunit processome|U3 snoRNA binding" hsa03008 Ribosome biogenesis in eukaryotes TBP 341.455979 341.0252054 341.8867525 1.002526345 0.003640149 1 1 9.300874307 9.726027629 6908 TATA-box binding protein "GO:0000785,GO:0000791,GO:0000976,GO:0000978,GO:0000979,GO:0000995,GO:0001046,GO:0001091,GO:0001093,GO:0001103,GO:0001939,GO:0001940,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005672,GO:0005737,GO:0006352,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006383,GO:0007283,GO:0008134,GO:0016032,GO:0016251,GO:0017162,GO:0019899,GO:0032991,GO:0042795,GO:0045815,GO:0045893,GO:0051123,GO:0070491,GO:0097550,GO:0140223,GO:1901796" "chromatin|euchromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase III general transcription initiation factor activity|core promoter sequence-specific DNA binding|RNA polymerase II general transcription initiation factor binding|TFIIB-class transcription factor binding|RNA polymerase II repressing transcription factor binding|female pronucleus|male pronucleus|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIA complex|cytoplasm|DNA-templated transcription, initiation|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription by RNA polymerase III|spermatogenesis|transcription factor binding|viral process|RNA polymerase II general transcription initiation factor activity|aryl hydrocarbon receptor binding|enzyme binding|protein-containing complex|snRNA transcription by RNA polymerase II|positive regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|RNA polymerase II preinitiation complex assembly|repressing transcription factor binding|transcription preinitiation complex|general transcription initiation factor activity|regulation of signal transduction by p53 class mediator" "hsa03022,hsa05016,hsa05017,hsa05165,hsa05166,hsa05203" Basal transcription factors|Huntington disease|Spinocerebellar ataxia|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis other TBPL1 329.739448 314.6363502 344.8425458 1.096003515 0.132252425 0.778324362 1 3.253413876 3.719351224 9519 TATA-box binding protein like 1 "GO:0000979,GO:0001675,GO:0005515,GO:0005672,GO:0005737,GO:0006235,GO:0006352,GO:0006366,GO:0007289,GO:0016251,GO:0140223" "RNA polymerase II core promoter sequence-specific DNA binding|acrosome assembly|protein binding|transcription factor TFIIA complex|cytoplasm|dTTP biosynthetic process|DNA-templated transcription, initiation|transcription by RNA polymerase II|spermatid nucleus differentiation|RNA polymerase II general transcription initiation factor activity|general transcription initiation factor activity" "hsa03022,hsa05016,hsa05017,hsa05165,hsa05166,hsa05203" Basal transcription factors|Huntington disease|Spinocerebellar ataxia|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis TBR1 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.054024109 0.013675687 10716 T-box brain transcription factor 1 "GO:0000978,GO:0000981,GO:0001661,GO:0001708,GO:0001947,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0010092,GO:0010975,GO:0019901,GO:0021764,GO:0021902,GO:0021987,GO:0030902,GO:0042802,GO:0045892,GO:0045944,GO:1902667" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|conditioned taste aversion|cell fate specification|heart looping|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|specification of animal organ identity|regulation of neuron projection development|protein kinase binding|amygdala development|commitment of neuronal cell to specific neuron type in forebrain|cerebral cortex development|hindbrain development|identical protein binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of axon guidance" TBRG1 717.8376264 577.509946 858.1653068 1.485974939 0.571409785 0.128580051 1 3.885340254 6.022217998 84897 transforming growth factor beta regulator 1 "GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0007050,GO:0008285,GO:0050821,GO:1990173" protein binding|nucleus|nucleoplasm|DNA replication|cell cycle arrest|negative regulation of cell population proliferation|protein stabilization|protein localization to nucleoplasm TBRG4 1678.45757 1654.378228 1702.536912 1.029109839 0.041396972 0.901080611 1 37.64080008 40.40512978 9238 transforming growth factor beta regulator 4 "GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0007050,GO:0008284,GO:0016071,GO:0044528,GO:0090615" RNA binding|protein binding|mitochondrion|mitochondrial matrix|cell cycle arrest|positive regulation of cell population proliferation|mRNA metabolic process|regulation of mitochondrial mRNA stability|mitochondrial mRNA processing TBX1 22.77984779 8.119647747 37.44004783 4.61104336 2.205093232 0.048321428 1 0.079990569 0.384728111 6899 T-box transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001525,GO:0001568,GO:0001708,GO:0001755,GO:0001934,GO:0001945,GO:0002053,GO:0003007,GO:0003148,GO:0003151,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007368,GO:0007389,GO:0007498,GO:0007507,GO:0007517,GO:0007605,GO:0008283,GO:0008284,GO:0009952,GO:0021644,GO:0030855,GO:0030878,GO:0035176,GO:0035909,GO:0042471,GO:0042472,GO:0042473,GO:0042474,GO:0042475,GO:0042693,GO:0042803,GO:0043410,GO:0043565,GO:0043587,GO:0044344,GO:0045596,GO:0045893,GO:0045944,GO:0048384,GO:0048514,GO:0048538,GO:0048644,GO:0048701,GO:0048703,GO:0048752,GO:0048844,GO:0050679,GO:0060017,GO:0060023,GO:0060037,GO:0060325,GO:0060415,GO:0060982,GO:0070166,GO:0071300,GO:0090103,GO:0097152,GO:1990837,GO:2000027,GO:2001037,GO:2001054" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|angiogenesis|blood vessel development|cell fate specification|neural crest cell migration|positive regulation of protein phosphorylation|lymph vessel development|positive regulation of mesenchymal cell proliferation|heart morphogenesis|outflow tract septum morphogenesis|outflow tract morphogenesis|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|determination of left/right symmetry|pattern specification process|mesoderm development|heart development|muscle organ development|sensory perception of sound|cell population proliferation|positive regulation of cell population proliferation|anterior/posterior pattern specification|vagus nerve morphogenesis|epithelial cell differentiation|thyroid gland development|social behavior|aorta morphogenesis|ear morphogenesis|inner ear morphogenesis|outer ear morphogenesis|middle ear morphogenesis|odontogenesis of dentin-containing tooth|muscle cell fate commitment|protein homodimerization activity|positive regulation of MAPK cascade|sequence-specific DNA binding|tongue morphogenesis|cellular response to fibroblast growth factor stimulus|negative regulation of cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|blood vessel morphogenesis|thymus development|muscle organ morphogenesis|embryonic cranial skeleton morphogenesis|embryonic viscerocranium morphogenesis|semicircular canal morphogenesis|artery morphogenesis|positive regulation of epithelial cell proliferation|parathyroid gland development|soft palate development|pharyngeal system development|face morphogenesis|muscle tissue morphogenesis|coronary artery morphogenesis|enamel mineralization|cellular response to retinoic acid|cochlea morphogenesis|mesenchymal cell apoptotic process|sequence-specific double-stranded DNA binding|regulation of animal organ morphogenesis|positive regulation of tongue muscle cell differentiation|negative regulation of mesenchymal cell apoptotic process" TBX15 47.18604996 26.38885518 67.98324474 2.57621046 1.365250457 0.117269776 1 0.293221242 0.787939183 6913 T-box transcription factor 15 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001708,GO:0005515,GO:0006357,GO:0042803,GO:0048701,GO:0090571,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cell fate specification|protein binding|regulation of transcription by RNA polymerase II|protein homodimerization activity|embryonic cranial skeleton morphogenesis|RNA polymerase II transcription repressor complex|sequence-specific double-stranded DNA binding" TBX19 35.87035495 27.40381115 44.33689874 1.617909951 0.694131313 0.466633828 1 0.464960255 0.784668297 9095 T-box transcription factor 19 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001707,GO:0001708,GO:0001756,GO:0003007,GO:0005515,GO:0005634,GO:0006357,GO:0009653,GO:0021983,GO:0042127,GO:0045595,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|mesoderm formation|cell fate specification|somitogenesis|heart morphogenesis|protein binding|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|pituitary gland development|regulation of cell population proliferation|regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TBX2 312.9211672 242.5744764 383.267858 1.580000764 0.659925256 0.157770449 1 3.578660495 5.897850038 6909 T-box transcription factor 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001708,GO:0001947,GO:0003148,GO:0003151,GO:0003203,GO:0003256,GO:0003677,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007219,GO:0007521,GO:0007569,GO:0008016,GO:0008284,GO:0035050,GO:0035909,GO:0036302,GO:0042733,GO:0043565,GO:0045892,GO:0048596,GO:0048738,GO:0051145,GO:0060021,GO:0060045,GO:0060465,GO:0060560,GO:0060596,GO:0072105,GO:0090398,GO:1901208,GO:1901211,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cell fate specification|heart looping|outflow tract septum morphogenesis|outflow tract morphogenesis|endocardial cushion morphogenesis|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|DNA binding|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|Notch signaling pathway|muscle cell fate determination|cell aging|regulation of heart contraction|positive regulation of cell population proliferation|embryonic heart tube development|aorta morphogenesis|atrioventricular canal development|embryonic digit morphogenesis|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|embryonic camera-type eye morphogenesis|cardiac muscle tissue development|smooth muscle cell differentiation|roof of mouth development|positive regulation of cardiac muscle cell proliferation|pharynx development|developmental growth involved in morphogenesis|mammary placode formation|ureteric peristalsis|cellular senescence|negative regulation of heart looping|negative regulation of cardiac chamber formation|sequence-specific double-stranded DNA binding" TBX20 83.20486266 63.94222601 102.4674993 1.602501285 0.680325513 0.347127656 1 0.449909443 0.752037375 57057 T-box transcription factor 20 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001085,GO:0001102,GO:0001228,GO:0001569,GO:0001570,GO:0001706,GO:0001708,GO:0001764,GO:0001947,GO:0003143,GO:0003148,GO:0003175,GO:0003180,GO:0003193,GO:0003203,GO:0003207,GO:0003215,GO:0003272,GO:0003279,GO:0003344,GO:0005634,GO:0005737,GO:0006357,GO:0006936,GO:0008015,GO:0008283,GO:0009953,GO:0010991,GO:0021524,GO:0035922,GO:0036306,GO:0045892,GO:0045944,GO:0048370,GO:0055008,GO:0060045,GO:0060413,GO:0060577,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|branching involved in blood vessel morphogenesis|vasculogenesis|endoderm formation|cell fate specification|neuron migration|heart looping|embryonic heart tube morphogenesis|outflow tract septum morphogenesis|tricuspid valve development|aortic valve morphogenesis|pulmonary valve formation|endocardial cushion morphogenesis|cardiac chamber formation|cardiac right ventricle morphogenesis|endocardial cushion formation|cardiac septum development|pericardium morphogenesis|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|muscle contraction|blood circulation|cell population proliferation|dorsal/ventral pattern formation|negative regulation of SMAD protein complex assembly|visceral motor neuron differentiation|foramen ovale closure|embryonic heart tube elongation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lateral mesoderm formation|cardiac muscle tissue morphogenesis|positive regulation of cardiac muscle cell proliferation|atrial septum morphogenesis|pulmonary vein morphogenesis|sequence-specific double-stranded DNA binding" TBX3 916.5460635 1330.607275 502.4848524 0.377635732 -1.404932815 0.000113382 0.018079825 14.06020537 5.538353534 6926 T-box transcription factor 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001102,GO:0001227,GO:0001501,GO:0001568,GO:0001701,GO:0001708,GO:0001947,GO:0003151,GO:0003167,GO:0003205,GO:0005515,GO:0005634,GO:0006357,GO:0007417,GO:0007569,GO:0008284,GO:0008595,GO:0009887,GO:0010159,GO:0019827,GO:0021761,GO:0030539,GO:0030540,GO:0030857,GO:0030879,GO:0032275,GO:0035115,GO:0035116,GO:0035136,GO:0042733,GO:0043066,GO:0043565,GO:0045662,GO:0045787,GO:0045892,GO:0045893,GO:0046884,GO:0048332,GO:0051145,GO:0060021,GO:0060412,GO:0060444,GO:0060596,GO:0060923,GO:0060931,GO:0072105,GO:0090398,GO:1990837,GO:2000648" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|blood vessel development|in utero embryonic development|cell fate specification|heart looping|outflow tract morphogenesis|atrioventricular bundle cell differentiation|cardiac chamber development|protein binding|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|cell aging|positive regulation of cell population proliferation|anterior/posterior axis specification, embryo|animal organ morphogenesis|specification of animal organ position|stem cell population maintenance|limbic system development|male genitalia development|female genitalia development|negative regulation of epithelial cell differentiation|mammary gland development|luteinizing hormone secretion|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|forelimb morphogenesis|embryonic digit morphogenesis|negative regulation of apoptotic process|sequence-specific DNA binding|negative regulation of myoblast differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|follicle-stimulating hormone secretion|mesoderm morphogenesis|smooth muscle cell differentiation|roof of mouth development|ventricular septum morphogenesis|branching involved in mammary gland duct morphogenesis|mammary placode formation|cardiac muscle cell fate commitment|sinoatrial node cell development|ureteric peristalsis|cellular senescence|sequence-specific double-stranded DNA binding|positive regulation of stem cell proliferation" hsa04550 Signaling pathways regulating pluripotency of stem cells T-box TBX6 16.55377839 20.29911937 12.80843742 0.630984881 -0.664322658 0.596432277 1 0.45510349 0.299533257 6911 T-box transcription factor 6 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001102,GO:0001707,GO:0001708,GO:0001947,GO:0003205,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007417,GO:0007498,GO:0008284,GO:0009653,GO:0010977,GO:0014043,GO:0023019,GO:0032525,GO:0043433,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|mesoderm formation|cell fate specification|heart looping|cardiac chamber development|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|mesoderm development|positive regulation of cell population proliferation|anatomical structure morphogenesis|negative regulation of neuron projection development|negative regulation of neuron maturation|signal transduction involved in regulation of gene expression|somite rostral/caudal axis specification|negative regulation of DNA-binding transcription factor activity|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TBXA2R 87.8463934 78.15160956 97.54117724 1.248101962 0.319735798 0.660112391 1 0.854144006 1.111980299 6915 thromboxane A2 receptor "GO:0001669,GO:0004961,GO:0005085,GO:0005515,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007189,GO:0007204,GO:0007584,GO:0016607,GO:0030194,GO:0033574,GO:0038193,GO:0042493,GO:0045471,GO:0045766,GO:0045777,GO:0045907,GO:0045987,GO:0050790,GO:0071222,GO:0090051" acrosomal vesicle|thromboxane A2 receptor activity|guanyl-nucleotide exchange factor activity|protein binding|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|response to nutrient|nuclear speck|positive regulation of blood coagulation|response to testosterone|thromboxane A2 signaling pathway|response to drug|response to ethanol|positive regulation of angiogenesis|positive regulation of blood pressure|positive regulation of vasoconstriction|positive regulation of smooth muscle contraction|regulation of catalytic activity|cellular response to lipopolysaccharide|negative regulation of cell migration involved in sprouting angiogenesis "hsa04020,hsa04080,hsa04611" Calcium signaling pathway|Neuroactive ligand-receptor interaction|Platelet activation TBXAS1 34.22643318 49.73284245 18.72002391 0.376411703 -1.409616612 0.141463877 1 0.284641544 0.111757669 6916 thromboxane A synthase 1 "GO:0001516,GO:0004497,GO:0004796,GO:0005506,GO:0005789,GO:0006690,GO:0016021,GO:0016705,GO:0019371,GO:0020037,GO:0036134,GO:0055114,GO:0106256" "prostaglandin biosynthetic process|monooxygenase activity|thromboxane-A synthase activity|iron ion binding|endoplasmic reticulum membrane|icosanoid metabolic process|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|cyclooxygenase pathway|heme binding|12-hydroxyheptadecatrienoic acid synthase activity|oxidation-reduction process|hydroperoxy icosatetraenoate dehydratase activity" "hsa00590,hsa04611" Arachidonic acid metabolism|Platelet activation TC2N 26.34703945 16.23929549 36.45478341 2.244850057 1.166619084 0.259860921 1 0.151438598 0.354600913 123036 "tandem C2 domains, nuclear" "GO:0003674,GO:0005575,GO:0005634" molecular_function|cellular_component|nucleus TCAF1 1266.695724 1053.524295 1479.867154 1.404682512 0.490244088 0.148731855 1 8.511291903 12.47066436 9747 TRPM8 channel associated factor 1 "GO:0005515,GO:0005886,GO:0010359,GO:0030336,GO:0044325,GO:0090314,GO:1901529" protein binding|plasma membrane|regulation of anion channel activity|negative regulation of cell migration|ion channel binding|positive regulation of protein targeting to membrane|positive regulation of anion channel activity TCAF2 39.01642168 74.09178569 3.941057666 0.05319156 -4.23265884 0.000131635 0.019824305 0.416295492 0.023097255 285966 TRPM8 channel associated factor 2 "GO:0005886,GO:0010359,GO:0010360,GO:0030054,GO:0030335,GO:0044325,GO:0090314" plasma membrane|regulation of anion channel activity|negative regulation of anion channel activity|cell junction|positive regulation of cell migration|ion channel binding|positive regulation of protein targeting to membrane TCAIM 532.8860265 461.8049656 603.9670873 1.307840176 0.387186247 0.336148551 1 4.5459266 6.201446813 285343 "T cell activation inhibitor, mitochondrial" GO:0005739 mitochondrion TCAP 7.030462899 9.134603715 4.926322083 0.539303317 -0.890831188 0.625563046 1 0.48191193 0.271091998 8557 titin-cap "GO:0001756,GO:0003009,GO:0003300,GO:0005515,GO:0005829,GO:0007512,GO:0008307,GO:0014898,GO:0030018,GO:0030049,GO:0030240,GO:0030241,GO:0030674,GO:0030916,GO:0031432,GO:0031674,GO:0035994,GO:0035995,GO:0036122,GO:0044325,GO:0045214,GO:0048739,GO:0048769,GO:0050982,GO:0051373,GO:0055003,GO:0055008,GO:0060048,GO:0065003,GO:0070080" somitogenesis|skeletal muscle contraction|cardiac muscle hypertrophy|protein binding|cytosol|adult heart development|structural constituent of muscle|cardiac muscle hypertrophy in response to stress|Z disc|muscle filament sliding|skeletal muscle thin filament assembly|skeletal muscle myosin thick filament assembly|protein-macromolecule adaptor activity|otic vesicle formation|titin binding|I band|response to muscle stretch|detection of muscle stretch|BMP binding|ion channel binding|sarcomere organization|cardiac muscle fiber development|sarcomerogenesis|detection of mechanical stimulus|FATZ binding|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|cardiac muscle contraction|protein-containing complex assembly|titin Z domain binding TCEA1 3974.116987 3573.659965 4374.574009 1.224115907 0.291740168 0.360083583 1 60.0707833 76.70113072 6917 transcription elongation factor A1 "GO:0003677,GO:0005515,GO:0005654,GO:0005669,GO:0005730,GO:0006283,GO:0006366,GO:0006368,GO:0008270,GO:0045944,GO:1901919" DNA binding|protein binding|nucleoplasm|transcription factor TFIID complex|nucleolus|transcription-coupled nucleotide-excision repair|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|zinc ion binding|positive regulation of transcription by RNA polymerase II|positive regulation of exoribonuclease activity TCEA2 1050.011782 1058.599075 1041.424488 0.983776118 -0.023598062 0.949041861 1 10.43689092 10.70984904 6919 transcription elongation factor A2 "GO:0003677,GO:0005515,GO:0005654,GO:0005813,GO:0006354,GO:0008023,GO:0008270,GO:0032784,GO:0045944" "DNA binding|protein binding|nucleoplasm|centrosome|DNA-templated transcription, elongation|transcription elongation factor complex|zinc ion binding|regulation of DNA-templated transcription, elongation|positive regulation of transcription by RNA polymerase II" TCEA3 199.4133617 161.377999 237.4487244 1.471382257 0.5571721 0.302577056 1 3.42980543 5.263939972 6920 transcription elongation factor A3 "GO:0003677,GO:0005515,GO:0005634,GO:0006351,GO:0006355,GO:0008270" "DNA binding|protein binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding" TCEAL1 346.8128285 370.4589285 323.1667286 0.872341584 -0.19703493 0.666518822 1 14.82025105 13.48522093 9338 transcription elongation factor A like 1 "GO:0005634,GO:0005654,GO:0010629,GO:0050699" nucleus|nucleoplasm|negative regulation of gene expression|WW domain binding TCEAL3 815.9563051 819.0694665 812.8431437 0.992398297 -0.011008835 0.979733601 1 39.28312403 40.66379977 85012 transcription elongation factor A like 3 "GO:0005634,GO:0050699" nucleus|WW domain binding TCEAL4 1075.329019 1071.793503 1078.864536 1.006597384 0.009486754 0.981242443 1 24.87743348 26.12024829 79921 transcription elongation factor A like 4 "GO:0005515,GO:0005634,GO:0050699" protein binding|nucleus|WW domain binding TCEAL8 1396.581635 1479.805802 1313.357467 0.88752015 -0.17214822 0.607750907 1 63.83896373 59.09897932 90843 transcription elongation factor A like 8 "GO:0005515,GO:0005634,GO:0050699" protein binding|nucleus|WW domain binding TCEAL9 1396.937933 1504.164745 1289.711121 0.857426772 -0.221914632 0.507682361 1 74.10567896 66.27724688 51186 transcription elongation factor A like 9 "GO:0005634,GO:0050699" nucleus|WW domain binding TCEANC 25.59930745 32.47859099 18.72002391 0.57638042 -0.794906768 0.451170008 1 0.48252451 0.290097862 170082 transcription elongation factor A N-terminal and central domain containing "GO:0005515,GO:0005634,GO:0006351" "protein binding|nucleus|transcription, DNA-templated" TCEANC2 425.0225834 362.3392807 487.7058862 1.345992312 0.42867017 0.31518477 1 1.759632401 2.470474977 127428 transcription elongation factor A N-terminal and central domain containing 2 "GO:0005515,GO:0005634,GO:0006351" "protein binding|nucleus|transcription, DNA-templated" TCERG1 1370.925666 1409.77384 1332.077491 0.944887367 -0.081785729 0.809062896 1 13.13708769 12.94777283 10915 transcription elongation regulator 1 "GO:0000122,GO:0001103,GO:0003711,GO:0003712,GO:0003713,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0016607,GO:0032968,GO:0034244,GO:0042802,GO:0044390,GO:0045944,GO:0070063" negative regulation of transcription by RNA polymerase II|RNA polymerase II repressing transcription factor binding|transcription elongation regulator activity|transcription coregulator activity|transcription coactivator activity|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|nuclear speck|positive regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter|identical protein binding|ubiquitin-like protein conjugating enzyme binding|positive regulation of transcription by RNA polymerase II|RNA polymerase binding hsa03040 Spliceosome TCF12 1515.77834 1545.77794 1485.77874 0.961185111 -0.057113794 0.864803673 1 9.26158754 9.285566411 6938 transcription factor 12 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006357,GO:0006955,GO:0007399,GO:0007517,GO:0008134,GO:0016607,GO:0030154,GO:0035497,GO:0043231,GO:0043425,GO:0045666,GO:0045944,GO:0046332,GO:0046982,GO:0070888,GO:0071837,GO:0090575,GO:1902036,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|immune response|nervous system development|muscle organ development|transcription factor binding|nuclear speck|cell differentiation|cAMP response element binding|intracellular membrane-bounded organelle|bHLH transcription factor binding|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|SMAD binding|protein heterodimerization activity|E-box binding|HMG box domain binding|RNA polymerase II transcription regulator complex|regulation of hematopoietic stem cell differentiation|sequence-specific double-stranded DNA binding" bHLH TCF19 1423.290662 1082.958018 1763.623306 1.628524168 0.70356513 0.035560373 0.850062245 17.48979693 29.70947004 6941 transcription factor 19 "GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0010468,GO:0046872" "DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of gene expression|metal ion binding" TCF20 1806.105974 1691.931599 1920.280348 1.134963345 0.182645705 0.5745809 1 9.557257052 11.31438708 6942 transcription factor 20 "GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0016604,GO:0045944,GO:0046872" DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nuclear body|positive regulation of transcription by RNA polymerase II|metal ion binding TCF21 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.042628717 6943 transcription factor 21 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0001228,GO:0001657,GO:0001658,GO:0001763,GO:0001822,GO:0001944,GO:0005515,GO:0005634,GO:0006357,GO:0007530,GO:0014707,GO:0030855,GO:0032502,GO:0032835,GO:0042826,GO:0043425,GO:0045944,GO:0046983,GO:0048286,GO:0048536,GO:0048557,GO:0048608,GO:0048732,GO:0050681,GO:0060008,GO:0060021,GO:0060425,GO:0060426,GO:0060435,GO:0060539,GO:0060541,GO:0060766,GO:0070888,GO:0072162,GO:0072277,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|ureteric bud development|branching involved in ureteric bud morphogenesis|morphogenesis of a branching structure|kidney development|vasculature development|protein binding|nucleus|regulation of transcription by RNA polymerase II|sex determination|branchiomeric skeletal muscle development|epithelial cell differentiation|developmental process|glomerulus development|histone deacetylase binding|bHLH transcription factor binding|positive regulation of transcription by RNA polymerase II|protein dimerization activity|lung alveolus development|spleen development|embryonic digestive tract morphogenesis|reproductive structure development|gland development|androgen receptor binding|Sertoli cell differentiation|roof of mouth development|lung morphogenesis|lung vasculature development|bronchiole development|diaphragm development|respiratory system development|negative regulation of androgen receptor signaling pathway|E-box binding|metanephric mesenchymal cell differentiation|metanephric glomerular capillary formation|sequence-specific double-stranded DNA binding" bHLH TCF24 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.083890558 0.084944372 100129654 transcription factor 24 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0032502,GO:0046983" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|developmental process|protein dimerization activity" TCF25 1537.825302 1571.151839 1504.498764 0.957576936 -0.062539691 0.851604174 1 24.33434188 24.30576039 22980 transcription factor 25 "GO:0000122,GO:0003677,GO:0003714,GO:0005515,GO:0005634,GO:0007507,GO:1990112" negative regulation of transcription by RNA polymerase II|DNA binding|transcription corepressor activity|protein binding|nucleus|heart development|RQC complex TCF3 1867.749826 1629.004329 2106.495323 1.293118308 0.370854274 0.252477645 1 16.60360686 22.39528698 6929 transcription factor 3 "GO:0000122,GO:0000785,GO:0000791,GO:0000978,GO:0000981,GO:0000987,GO:0001102,GO:0001227,GO:0001228,GO:0002326,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006355,GO:0006357,GO:0007399,GO:0008134,GO:0030183,GO:0031435,GO:0033152,GO:0042803,GO:0043425,GO:0045666,GO:0045893,GO:0045944,GO:0046982,GO:0051091,GO:0051149,GO:0070491,GO:0070644,GO:0070888,GO:0090575,GO:1902036" "negative regulation of transcription by RNA polymerase II|chromatin|euchromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|B cell lineage commitment|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nervous system development|transcription factor binding|B cell differentiation|mitogen-activated protein kinase kinase kinase binding|immunoglobulin V(D)J recombination|protein homodimerization activity|bHLH transcription factor binding|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of DNA-binding transcription factor activity|positive regulation of muscle cell differentiation|repressing transcription factor binding|vitamin D response element binding|E-box binding|RNA polymerase II transcription regulator complex|regulation of hematopoietic stem cell differentiation" "hsa04550,hsa05166,hsa05202" Signaling pathways regulating pluripotency of stem cells|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer bHLH TCF4 867.1752089 818.0545105 916.2959074 1.120091504 0.163616596 0.652545103 1 3.69166667 4.313123697 6925 transcription factor 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001093,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007399,GO:0008013,GO:0008022,GO:0030154,GO:0042802,GO:0045666,GO:0045893,GO:0045944,GO:0046982,GO:0065004,GO:0070369,GO:0070888,GO:1990837,GO:1990907" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|TFIIB-class transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|nervous system development|beta-catenin binding|protein C-terminus binding|cell differentiation|identical protein binding|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|protein-DNA complex assembly|beta-catenin-TCF7L2 complex|E-box binding|sequence-specific double-stranded DNA binding|beta-catenin-TCF complex" bHLH TCF7 225.594376 199.9463258 251.2424262 1.256549353 0.329467336 0.52784037 1 0.708102652 0.928093437 6932 transcription factor 7 "GO:0000976,GO:0000978,GO:0000981,GO:0001217,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006955,GO:0008013,GO:0016604,GO:0033153,GO:0042492,GO:0045586,GO:0045892,GO:0060070,GO:0071353,GO:1904837,GO:1990837,GO:1990907" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|immune response|beta-catenin binding|nuclear body|T cell receptor V(D)J recombination|gamma-delta T cell differentiation|regulation of gamma-delta T cell differentiation|negative regulation of transcription, DNA-templated|canonical Wnt signaling pathway|cellular response to interleukin-4|beta-catenin-TCF complex assembly|sequence-specific double-stranded DNA binding|beta-catenin-TCF complex" "hsa04310,hsa04390,hsa04520,hsa04550,hsa04916,hsa04934,hsa05132,hsa05165,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412" Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Salmonella infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy TCF7L1 239.4919983 207.0510175 271.932979 1.313362195 0.393264834 0.440903661 1 3.509505892 4.807800262 83439 transcription factor 7 like 1 "GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006325,GO:0006355,GO:0006357,GO:0008013,GO:0030111,GO:0060070,GO:1904837,GO:1990837,GO:1990907" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|chromatin organization|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|beta-catenin binding|regulation of Wnt signaling pathway|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|sequence-specific double-stranded DNA binding|beta-catenin-TCF complex" "hsa04310,hsa04390,hsa04520,hsa04916,hsa04934,hsa05132,hsa05165,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412" Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Salmonella infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy TCF7L2 405.1727967 487.1788648 323.1667286 0.66334308 -0.592172872 0.170771133 1 4.658967303 3.223619656 6934 transcription factor 7 like 2 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001103,GO:0001568,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007050,GO:0007223,GO:0008013,GO:0008134,GO:0009749,GO:0010909,GO:0016605,GO:0019901,GO:0031016,GO:0032024,GO:0032092,GO:0032350,GO:0032993,GO:0035257,GO:0042593,GO:0043433,GO:0043565,GO:0043570,GO:0044334,GO:0045295,GO:0045444,GO:0045892,GO:0045944,GO:0046827,GO:0048625,GO:0048660,GO:0050679,GO:0051897,GO:0060070,GO:0070016,GO:0070369,GO:0071664,GO:0090090,GO:1904837,GO:1990907,GO:2000675,GO:2001237" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|blood vessel development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell cycle arrest|Wnt signaling pathway, calcium modulating pathway|beta-catenin binding|transcription factor binding|response to glucose|positive regulation of heparan sulfate proteoglycan biosynthetic process|PML body|protein kinase binding|pancreas development|positive regulation of insulin secretion|positive regulation of protein binding|regulation of hormone metabolic process|protein-DNA complex|nuclear hormone receptor binding|glucose homeostasis|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|maintenance of DNA repeat elements|canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition|gamma-catenin binding|fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of protein export from nucleus|myoblast fate commitment|regulation of smooth muscle cell proliferation|positive regulation of epithelial cell proliferation|positive regulation of protein kinase B signaling|canonical Wnt signaling pathway|armadillo repeat domain binding|beta-catenin-TCF7L2 complex|catenin-TCF7L2 complex|negative regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex|negative regulation of type B pancreatic cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway" "hsa04310,hsa04390,hsa04520,hsa04916,hsa04934,hsa05132,hsa05165,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412" Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Salmonella infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy HMG TCFL5 901.8821502 833.27885 970.4854503 1.164658686 0.219907221 0.541103769 1 8.370217002 10.16836945 10732 transcription factor like 5 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001673,GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0006366,GO:0007275,GO:0007283,GO:0030154,GO:0042127,GO:0045595,GO:0046983,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|male germ cell nucleus|DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|transcription by RNA polymerase II|multicellular organism development|spermatogenesis|cell differentiation|regulation of cell population proliferation|regulation of cell differentiation|protein dimerization activity|sequence-specific double-stranded DNA binding" TCHP 455.9814621 390.7580478 521.2048764 1.333830178 0.415574995 0.321042614 1 5.426519498 7.549841541 84260 trichoplein keratin filament binding "GO:0005515,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0006915,GO:0030030,GO:0030057,GO:0030308,GO:0045095,GO:0045179,GO:1902018" protein binding|cytoplasm|mitochondrion|centrosome|cytosol|plasma membrane|apoptotic process|cell projection organization|desmosome|negative regulation of cell growth|keratin filament|apical cortex|negative regulation of cilium assembly TCIM 18.76183964 36.53841486 0.985264417 0.026965166 -5.212759283 0.000831121 0.080956814 1.011777919 0.02845799 56892 transcriptional and immune response regulator "GO:0002264,GO:0005112,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0010739,GO:0016607,GO:0034605,GO:0043066,GO:0043620,GO:0045746,GO:1900020,GO:1901224,GO:1902806,GO:1903706" endothelial cell activation involved in immune response|Notch binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|apoptotic process|positive regulation of protein kinase A signaling|nuclear speck|cellular response to heat|negative regulation of apoptotic process|regulation of DNA-templated transcription in response to stress|negative regulation of Notch signaling pathway|positive regulation of protein kinase C activity|positive regulation of NIK/NF-kappaB signaling|regulation of cell cycle G1/S phase transition|regulation of hemopoiesis TCIRG1 1541.626066 1460.521638 1622.730494 1.111062275 0.151939682 0.646526983 1 17.47054052 20.24699956 10312 "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3" "GO:0000045,GO:0000220,GO:0001503,GO:0002158,GO:0005215,GO:0005515,GO:0005634,GO:0005765,GO:0005770,GO:0005886,GO:0005887,GO:0006874,GO:0006915,GO:0006954,GO:0006968,GO:0007035,GO:0007039,GO:0008284,GO:0008286,GO:0010008,GO:0010155,GO:0010272,GO:0010467,GO:0010468,GO:0016064,GO:0016236,GO:0016324,GO:0016471,GO:0021554,GO:0030010,GO:0030183,GO:0030217,GO:0030316,GO:0030670,GO:0031529,GO:0033365,GO:0033572,GO:0034220,GO:0035709,GO:0035711,GO:0043029,GO:0043312,GO:0044691,GO:0045453,GO:0045667,GO:0046961,GO:0050796,GO:0051117,GO:0051650,GO:0060041,GO:0061484,GO:0070166,GO:0071345,GO:0090383,GO:0097188,GO:0101003,GO:1902600" "autophagosome assembly|vacuolar proton-transporting V-type ATPase, V0 domain|ossification|osteoclast proliferation|transporter activity|protein binding|nucleus|lysosomal membrane|late endosome|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|apoptotic process|inflammatory response|cellular defense response|vacuolar acidification|protein catabolic process in the vacuole|positive regulation of cell population proliferation|insulin receptor signaling pathway|endosome membrane|regulation of proton transport|response to silver ion|gene expression|regulation of gene expression|immunoglobulin mediated immune response|macroautophagy|apical plasma membrane|vacuolar proton-transporting V-type ATPase complex|optic nerve development|establishment of cell polarity|B cell differentiation|T cell differentiation|osteoclast differentiation|phagocytic vesicle membrane|ruffle organization|protein localization to organelle|transferrin transport|ion transmembrane transport|memory T cell activation|T-helper 1 cell activation|T cell homeostasis|neutrophil degranulation|tooth eruption|bone resorption|regulation of osteoblast differentiation|proton-transporting ATPase activity, rotational mechanism|regulation of insulin secretion|ATPase binding|establishment of vesicle localization|retina development in camera-type eye|hematopoietic stem cell homeostasis|enamel mineralization|cellular response to cytokine stimulus|phagosome acidification|dentin mineralization|ficolin-1-rich granule membrane|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis TCN2 102.6968669 116.7199364 88.67379749 0.759714238 -0.396471236 0.56054915 1 2.800309338 2.219076141 6948 transcobalamin 2 "GO:0005515,GO:0005576,GO:0005615,GO:0005768,GO:0006824,GO:0009235,GO:0015889,GO:0031419,GO:0043202,GO:0046872" protein binding|extracellular region|extracellular space|endosome|cobalt ion transport|cobalamin metabolic process|cobalamin transport|cobalamin binding|lysosomal lumen|metal ion binding hsa04977 Vitamin digestion and absorption TCOF1 2905.251323 2876.385214 2934.117432 1.020071101 0.028669714 0.929294102 1 24.07515515 25.616245 6949 treacle ribosome biogenesis factor 1 "GO:0001501,GO:0001650,GO:0003723,GO:0005215,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006417,GO:0014029,GO:0014032,GO:0030674,GO:0042790,GO:0046982,GO:0097110" skeletal system development|fibrillar center|RNA binding|transporter activity|protein binding|nucleoplasm|nucleolus|cytosol|regulation of translation|neural crest formation|neural crest cell development|protein-macromolecule adaptor activity|nucleolar large rRNA transcription by RNA polymerase I|protein heterodimerization activity|scaffold protein binding hsa03008 Ribosome biogenesis in eukaryotes TCP1 3701.940786 3994.866692 3409.014881 0.853348846 -0.228792464 0.472405838 1 86.02291874 76.56965834 6950 t-complex 1 "GO:0000242,GO:0000792,GO:0001669,GO:0002199,GO:0003723,GO:0005515,GO:0005524,GO:0005794,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007021,GO:0007339,GO:0031625,GO:0032212,GO:0035722,GO:0044053,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0051973,GO:0070062,GO:0090666,GO:1901998,GO:1904851,GO:1904871,GO:1904874,GO:2000109" pericentriolar material|heterochromatin|acrosomal vesicle|zona pellucida receptor complex|RNA binding|protein binding|ATP binding|Golgi apparatus|centrosome|cytosol|chaperonin-containing T-complex|microtubule|protein folding|tubulin complex assembly|binding of sperm to zona pellucida|ubiquitin protein ligase binding|positive regulation of telomere maintenance via telomerase|interleukin-12-mediated signaling pathway|translocation of peptides or proteins into host cell cytoplasm|protein folding chaperone|cell body|protein stabilization|unfolded protein binding|positive regulation of telomerase activity|extracellular exosome|scaRNA localization to Cajal body|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body|regulation of macrophage apoptotic process TCP11L1 1216.476931 1055.554207 1377.399654 1.304906603 0.383946551 0.260803211 1 5.720104517 7.785729709 55346 t-complex 11 like 1 "GO:0005515,GO:0005874,GO:0007165" protein binding|microtubule|signal transduction TCP11L2 159.8812972 186.7518982 133.0106962 0.712232098 -0.48958064 0.400377176 1 1.808475109 1.343538165 255394 t-complex 11 like 2 "GO:0005515,GO:0007165" protein binding|signal transduction TCTA 466.9096831 565.3304744 368.4888918 0.651811478 -0.617473339 0.137843112 1 13.3358147 9.06687202 6988 T cell leukemia translocation altered "GO:0003674,GO:0005515,GO:0016021,GO:0045671,GO:0072675" molecular_function|protein binding|integral component of membrane|negative regulation of osteoclast differentiation|osteoclast fusion TCTN1 331.3658024 324.7859099 337.9456949 1.040518337 0.05730239 0.90705725 1 6.230780515 6.762513126 79600 tectonic family member 1 "GO:0001701,GO:0001841,GO:0005615,GO:0005829,GO:0005856,GO:0008589,GO:0016020,GO:0021523,GO:0021537,GO:0021904,GO:0021956,GO:0036038,GO:0060271,GO:0097711,GO:1904491" in utero embryonic development|neural tube formation|extracellular space|cytosol|cytoskeleton|regulation of smoothened signaling pathway|membrane|somatic motor neuron differentiation|telencephalon development|dorsal/ventral neural tube patterning|central nervous system interneuron axonogenesis|MKS complex|cilium assembly|ciliary basal body-plasma membrane docking|protein localization to ciliary transition zone TCTN2 1130.796783 957.1034782 1304.490088 1.362956166 0.446739165 0.195876934 1 16.64054745 23.65731368 79867 tectonic family member 2 "GO:0005737,GO:0005856,GO:0007224,GO:0016021,GO:0036038,GO:0060170,GO:0060271,GO:0097711,GO:1904491" cytoplasm|cytoskeleton|smoothened signaling pathway|integral component of membrane|MKS complex|ciliary membrane|cilium assembly|ciliary basal body-plasma membrane docking|protein localization to ciliary transition zone TCTN3 2384.876819 2394.281129 2375.472508 0.992144356 -0.011378049 0.973022605 1 48.15801934 49.83786307 26123 tectonic family member 3 "GO:0005515,GO:0005634,GO:0006915,GO:0007224,GO:0016021,GO:0043065,GO:0060170,GO:0060271,GO:0097711" protein binding|nucleus|apoptotic process|smoothened signaling pathway|integral component of membrane|positive regulation of apoptotic process|ciliary membrane|cilium assembly|ciliary basal body-plasma membrane docking TDG 564.6829495 648.5568638 480.8090353 0.741352165 -0.431769065 0.276492866 1 10.2231924 7.905457793 6996 thymine DNA glycosylase "GO:0000122,GO:0000287,GO:0003677,GO:0003684,GO:0003690,GO:0004844,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005886,GO:0006284,GO:0006285,GO:0006298,GO:0006325,GO:0008134,GO:0008263,GO:0019104,GO:0019904,GO:0030983,GO:0031402,GO:0031404,GO:0032183,GO:0035511,GO:0040029,GO:0042803,GO:0043621,GO:0043739,GO:0045008,GO:0045995,GO:0080111,GO:1902544" "negative regulation of transcription by RNA polymerase II|magnesium ion binding|DNA binding|damaged DNA binding|double-stranded DNA binding|uracil DNA N-glycosylase activity|protein binding|ATP binding|nucleus|nucleoplasm|plasma membrane|base-excision repair|base-excision repair, AP site formation|mismatch repair|chromatin organization|transcription factor binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity|DNA N-glycosylase activity|protein domain specific binding|mismatched DNA binding|sodium ion binding|chloride ion binding|SUMO binding|oxidative DNA demethylation|regulation of gene expression, epigenetic|protein homodimerization activity|protein self-association|G/U mismatch-specific uracil-DNA glycosylase activity|depyrimidination|regulation of embryonic development|DNA demethylation|regulation of DNA N-glycosylase activity" hsa03410 Base excision repair TDO2 4.52276453 6.08973581 2.95579325 0.485372985 -1.042834281 0.660953233 1 0.181425668 0.091852348 6999 "tryptophan 2,3-dioxygenase" "GO:0004833,GO:0005515,GO:0005829,GO:0006569,GO:0016597,GO:0019441,GO:0019442,GO:0019825,GO:0020037,GO:0042802,GO:0046872,GO:0051289,GO:0055114,GO:1904842" "tryptophan 2,3-dioxygenase activity|protein binding|cytosol|tryptophan catabolic process|amino acid binding|tryptophan catabolic process to kynurenine|tryptophan catabolic process to acetyl-CoA|oxygen binding|heme binding|identical protein binding|metal ion binding|protein homotetramerization|oxidation-reduction process|response to nitroglycerin" hsa00380 Tryptophan metabolism TDP1 1202.220288 1057.584119 1346.856457 1.273521825 0.348823684 0.307845764 1 10.16952814 13.50899759 55775 tyrosyl-DNA phosphodiesterase 1 "GO:0000012,GO:0003690,GO:0003697,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006281,GO:0006302,GO:0017005,GO:0043231,GO:0090305" single strand break repair|double-stranded DNA binding|single-stranded DNA binding|exonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|DNA repair|double-strand break repair|3'-tyrosyl-DNA phosphodiesterase activity|intracellular membrane-bounded organelle|nucleic acid phosphodiester bond hydrolysis TDP2 637.7761089 593.7492415 681.8029763 1.148301216 0.199501132 0.606592654 1 15.54072582 18.6141433 51567 tyrosyl-DNA phosphodiesterase 2 "GO:0000287,GO:0003697,GO:0003714,GO:0004518,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006302,GO:0007166,GO:0016032,GO:0016235,GO:0016604,GO:0016605,GO:0030145,GO:0036317,GO:0045892,GO:0048666,GO:0070260,GO:0090305" "magnesium ion binding|single-stranded DNA binding|transcription corepressor activity|nuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|double-strand break repair|cell surface receptor signaling pathway|viral process|aggresome|nuclear body|PML body|manganese ion binding|tyrosyl-RNA phosphodiesterase activity|negative regulation of transcription, DNA-templated|neuron development|5'-tyrosyl-DNA phosphodiesterase activity|nucleic acid phosphodiester bond hydrolysis" TDRD10 3.463271234 1.014955968 5.911586499 5.824475823 2.542128219 0.321345721 1 0.011528132 0.070037673 126668 tudor domain containing 10 GO:0003723 RNA binding TDRD3 163.3000311 184.7219862 141.878076 0.768062746 -0.38070392 0.511855381 1 2.619859127 2.098894308 81550 tudor domain containing 3 "GO:0003682,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006325,GO:0035064,GO:0035145,GO:0045893" "chromatin binding|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|chromatin organization|methylated histone binding|exon-exon junction complex|positive regulation of transcription, DNA-templated" TDRD6 8.478667972 7.104691779 9.852644165 1.386779958 0.471738892 0.817532793 1 0.040127978 0.058045794 221400 tudor domain containing 6 "GO:0005737,GO:0007275,GO:0007283,GO:0030154,GO:0033391" cytoplasm|multicellular organism development|spermatogenesis|cell differentiation|chromatoid body TDRD7 791.650064 672.915807 910.3843209 1.352894837 0.4360497 0.236409098 1 9.241001009 13.04064243 23424 tudor domain containing 7 "GO:0002089,GO:0003729,GO:0005515,GO:0005737,GO:0005759,GO:0007283,GO:0010608,GO:0033391,GO:0035770,GO:0047485,GO:0070306" lens morphogenesis in camera-type eye|mRNA binding|protein binding|cytoplasm|mitochondrial matrix|spermatogenesis|posttranscriptional regulation of gene expression|chromatoid body|ribonucleoprotein granule|protein N-terminus binding|lens fiber cell differentiation TDRKH 483.3434575 409.0272553 557.6596598 1.363380197 0.447187933 0.278218886 1 4.730711924 6.727588412 11022 tudor and KH domain containing "GO:0003723,GO:0005515,GO:0005739,GO:0007140,GO:0007283,GO:0009566,GO:0030154,GO:0031047,GO:0034587,GO:0043046,GO:0071546,GO:0071547" RNA binding|protein binding|mitochondrion|male meiotic nuclear division|spermatogenesis|fertilization|cell differentiation|gene silencing by RNA|piRNA metabolic process|DNA methylation involved in gamete generation|pi-body|piP-body TDRP 54.40950795 48.71788648 60.10112941 1.233656338 0.302940556 0.728583669 1 0.758030441 0.975431486 157695 testis development related protein "GO:0003674,GO:0005634,GO:0005737,GO:0005829,GO:0007283,GO:0043231" molecular_function|nucleus|cytoplasm|cytosol|spermatogenesis|intracellular membrane-bounded organelle TEAD1 3763.579442 3628.467587 3898.691296 1.074473232 0.103629542 0.745276312 1 19.51461005 21.87113935 7003 TEA domain transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0035329,GO:0045893,GO:0045944,GO:0048568,GO:0065003,GO:0140552,GO:1902895,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|hippo signaling|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic organ development|protein-containing complex assembly|TEAD-YAP complex|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species TEA TEAD2 625.4360553 524.7322356 726.139875 1.383829362 0.468666058 0.226384352 1 9.08265092 13.11025364 8463 TEA domain transcription factor 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001223,GO:0001570,GO:0001843,GO:0003143,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006355,GO:0006357,GO:0006367,GO:0030903,GO:0035329,GO:0043231,GO:0045893,GO:0045944,GO:0048339,GO:0048368,GO:0048568,GO:0060548,GO:0065003,GO:0071300,GO:0097718,GO:0140552,GO:1990837,GO:2000736" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription coactivator binding|vasculogenesis|neural tube closure|embryonic heart tube morphogenesis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|notochord development|hippo signaling|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|paraxial mesoderm development|lateral mesoderm development|embryonic organ development|negative regulation of cell death|protein-containing complex assembly|cellular response to retinoic acid|disordered domain specific binding|TEAD-YAP complex|sequence-specific double-stranded DNA binding|regulation of stem cell differentiation" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species TEAD3 371.9749275 272.0081995 471.9416555 1.735027313 0.794958374 0.073335301 1 4.613615445 8.349560923 7005 TEA domain transcription factor 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0003700,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007565,GO:0035329,GO:0045944,GO:0048568,GO:0055059" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|female pregnancy|hippo signaling|positive regulation of transcription by RNA polymerase II|embryonic organ development|asymmetric neuroblast division" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species TEAD4 711.5264417 718.5888256 704.4640578 0.980343741 -0.0286404 0.943262283 1 21.12245443 21.59925105 7004 TEA domain transcription factor 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001501,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007517,GO:0035329,GO:0048568" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|skeletal system development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|muscle organ development|hippo signaling|embryonic organ development" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species TEA TEC 117.5945994 124.8395841 110.3496147 0.88393129 -0.177993865 0.791974065 1 1.194085841 1.10095606 7006 tec protein tyrosine kinase "GO:0002250,GO:0004715,GO:0005515,GO:0005524,GO:0005543,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0007229,GO:0010543,GO:0018108,GO:0019221,GO:0035556,GO:0038083,GO:0038095,GO:0042246,GO:0046872,GO:0050731,GO:0050852,GO:0050853" adaptive immune response|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|phospholipid binding|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|integrin-mediated signaling pathway|regulation of platelet activation|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|intracellular signal transduction|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|tissue regeneration|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|T cell receptor signaling pathway|B cell receptor signaling pathway "hsa04380,hsa04660" Osteoclast differentiation|T cell receptor signaling pathway TECPR1 644.4866457 682.0504107 606.9228806 0.889850473 -0.168365163 0.663702346 1 5.232270096 4.856496947 25851 tectonin beta-propeller repeat containing 1 "GO:0000421,GO:0005515,GO:0005654,GO:0005765,GO:0006914,GO:0016021,GO:0031410,GO:0032266,GO:0043231,GO:0097352" autophagosome membrane|protein binding|nucleoplasm|lysosomal membrane|autophagy|integral component of membrane|cytoplasmic vesicle|phosphatidylinositol-3-phosphate binding|intracellular membrane-bounded organelle|autophagosome maturation hsa05131 Shigellosis TECPR2 940.7528357 863.7275291 1017.778142 1.178355567 0.236774936 0.507012615 1 4.825675929 5.931307513 9895 tectonin beta-propeller repeat containing 2 "GO:0005515,GO:0005737,GO:0006914,GO:0032527" protein binding|cytoplasm|autophagy|protein exit from endoplasmic reticulum TECR 1779.988302 1792.41224 1767.564363 0.986137186 -0.020139734 0.952466935 1 55.65871043 57.2514388 9524 "trans-2,3-enoyl-CoA reductase" "GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0006665,GO:0016491,GO:0030176,GO:0030497,GO:0035338,GO:0042761,GO:0055114,GO:0102758" protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|sphingolipid metabolic process|oxidoreductase activity|integral component of endoplasmic reticulum membrane|fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|oxidation-reduction process|very-long-chain enoyl-CoA reductase activity "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids TEDC1 384.9709168 352.189721 417.7521126 1.18615646 0.246294321 0.576662191 1 7.920589218 9.799759064 283643 tubulin epsilon and delta complex 1 "GO:0005515,GO:0005737,GO:0005814,GO:0005929,GO:0045880" protein binding|cytoplasm|centriole|cilium|positive regulation of smoothened signaling pathway TEDC2 165.0505949 136.0040998 194.0970901 1.427141464 0.513128348 0.372881614 1 4.218081971 6.279108237 80178 tubulin epsilon and delta complex 2 "GO:0005515,GO:0005737,GO:0005814,GO:0005929,GO:0045880" protein binding|cytoplasm|centriole|cilium|positive regulation of smoothened signaling pathway TEF 273.7953819 228.3650929 319.225671 1.397874198 0.48323453 0.321616789 1 2.555432243 3.726047512 7008 "TEF transcription factor, PAR bZIP family member" "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0048511,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|rhythmic process|sequence-specific double-stranded DNA binding" TEFM 219.605839 228.3650929 210.8465851 0.923287279 -0.115148486 0.833137224 1 4.283661604 4.12541779 79736 "transcription elongation factor, mitochondrial" "GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0006119,GO:0006259,GO:0006264,GO:0006390,GO:0006392,GO:0008821,GO:0030337,GO:0042645,GO:0050790,GO:1990904" RNA binding|protein binding|mitochondrion|mitochondrial matrix|oxidative phosphorylation|DNA metabolic process|mitochondrial DNA replication|mitochondrial transcription|transcription elongation from mitochondrial promoter|crossover junction endodeoxyribonuclease activity|DNA polymerase processivity factor activity|mitochondrial nucleoid|regulation of catalytic activity|ribonucleoprotein complex TELO2 566.3498819 526.7621476 605.9376162 1.150305919 0.202017591 0.612227739 1 6.703177002 8.042850045 9894 telomere maintenance 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007004,GO:0016020,GO:0016604,GO:0019901,GO:0031931,GO:0031932,GO:0032006,GO:0034399,GO:0042162,GO:0044877,GO:0050821,GO:0051879,GO:0060090,GO:0070209,GO:0071902,GO:1904263,GO:1904515" protein binding|nucleus|cytoplasm|cytosol|telomere maintenance via telomerase|membrane|nuclear body|protein kinase binding|TORC1 complex|TORC2 complex|regulation of TOR signaling|nuclear periphery|telomeric DNA binding|protein-containing complex binding|protein stabilization|Hsp90 protein binding|molecular adaptor activity|ASTRA complex|positive regulation of protein serine/threonine kinase activity|positive regulation of TORC1 signaling|positive regulation of TORC2 signaling "hsa03460,hsa04150" Fanconi anemia pathway|mTOR signaling pathway TEN1 254.9269002 218.2155332 291.6382673 1.336468871 0.418426235 0.402257018 1 11.34686544 15.81796762 100134934 TEN1 subunit of CST complex "GO:0000781,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0010521,GO:0016233,GO:0032211,GO:0042162,GO:0051974,GO:1990879" "chromosome, telomeric region|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|telomerase inhibitor activity|telomere capping|negative regulation of telomere maintenance via telomerase|telomeric DNA binding|negative regulation of telomerase activity|CST complex" TENM2 13.34560695 3.044867905 23.646346 7.765967764 2.957165719 0.034355104 0.832362361 0.009503995 0.076987053 57451 teneurin transmembrane protein 2 "GO:0000122,GO:0005509,GO:0005634,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0007157,GO:0007165,GO:0016605,GO:0030054,GO:0030175,GO:0030425,GO:0030426,GO:0042803,GO:0043005,GO:0043197,GO:0045202,GO:0045211,GO:0046982,GO:0048666,GO:0050839,GO:0051491,GO:0098609" negative regulation of transcription by RNA polymerase II|calcium ion binding|nucleus|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|PML body|cell junction|filopodium|dendrite|growth cone|protein homodimerization activity|neuron projection|dendritic spine|synapse|postsynaptic membrane|protein heterodimerization activity|neuron development|cell adhesion molecule binding|positive regulation of filopodium assembly|cell-cell adhesion TENM3 834.5966569 880.9817805 788.2115332 0.894696747 -0.160529324 0.66115684 1 3.819760232 3.564740259 55714 teneurin transmembrane protein 3 "GO:0005887,GO:0007156,GO:0007157,GO:0007165,GO:0010976,GO:0016020,GO:0030424,GO:0042803,GO:0043005,GO:0046982,GO:0048593,GO:0048666,GO:0050839,GO:1903385" integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|positive regulation of neuron projection development|membrane|axon|protein homodimerization activity|neuron projection|protein heterodimerization activity|camera-type eye morphogenesis|neuron development|cell adhesion molecule binding|regulation of homophilic cell adhesion TENM4 7.089846003 13.19442759 0.985264417 0.074672767 -3.743273999 0.05299914 1 0.041653756 0.003244385 26011 teneurin transmembrane protein 4 "GO:0001702,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0007157,GO:0007165,GO:0031641,GO:0031643,GO:0032289,GO:0042803,GO:0043005,GO:0046982,GO:0048666,GO:0048714,GO:0050839,GO:0060038,GO:0060912,GO:2000543" gastrulation with mouth forming second|protein binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|regulation of myelination|positive regulation of myelination|central nervous system myelin formation|protein homodimerization activity|neuron projection|protein heterodimerization activity|neuron development|positive regulation of oligodendrocyte differentiation|cell adhesion molecule binding|cardiac muscle cell proliferation|cardiac cell fate specification|positive regulation of gastrulation TENT2 892.136148 806.8899949 977.3823012 1.211295601 0.276550979 0.442549863 1 8.567323208 10.82458415 167153 terminal nucleotidyltransferase 2 "GO:0002244,GO:0004652,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006378,GO:0006397,GO:0016779,GO:0021766,GO:0030182,GO:0031380,GO:0034062,GO:0043489,GO:0043631,GO:0046872,GO:0060041,GO:0070566,GO:0071044,GO:1990603,GO:2000626" hematopoietic progenitor cell differentiation|polynucleotide adenylyltransferase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|mRNA polyadenylation|mRNA processing|nucleotidyltransferase activity|hippocampus development|neuron differentiation|nuclear RNA-directed RNA polymerase complex|5'-3' RNA polymerase activity|RNA stabilization|RNA polyadenylation|metal ion binding|retina development in camera-type eye|adenylyltransferase activity|histone mRNA catabolic process|dark adaptation|negative regulation of miRNA catabolic process TENT4A 2283.281261 2319.174388 2247.388134 0.969046634 -0.045362 0.888491711 1 14.76530499 14.9246113 11044 terminal nucleotidyltransferase 4A "GO:0004652,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005794,GO:0006302,GO:0006397,GO:0007062,GO:0007076,GO:0031123,GO:0031499,GO:0031965,GO:0042493,GO:0043221,GO:0043631,GO:0046872,GO:0060212,GO:0070568,GO:0071076,GO:1905870" polynucleotide adenylyltransferase activity|ATP binding|nucleus|nucleoplasm|nucleolus|Golgi apparatus|double-strand break repair|mRNA processing|sister chromatid cohesion|mitotic chromosome condensation|RNA 3'-end processing|TRAMP complex|nuclear membrane|response to drug|SMC family protein binding|RNA polyadenylation|metal ion binding|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|guanylyltransferase activity|RNA 3' uridylation|positive regulation of 3'-UTR-mediated mRNA stabilization hsa03018 RNA degradation TENT4B 259.9813911 294.3372308 225.6255514 0.766554577 -0.383539583 0.439993776 1 1.741081801 1.392124853 64282 terminal nucleotidyltransferase 4B "GO:0003677,GO:0003723,GO:0003887,GO:0004652,GO:0005515,GO:0005730,GO:0005737,GO:0006364,GO:0006378,GO:0007049,GO:0010587,GO:0031123,GO:0031499,GO:0032211,GO:0033500,GO:0043629,GO:0043630,GO:0046872,GO:0051301,GO:0060212,GO:0070034,GO:0070568,GO:0071044,GO:0071050,GO:0071076,GO:0071897,GO:1905870" DNA binding|RNA binding|DNA-directed DNA polymerase activity|polynucleotide adenylyltransferase activity|protein binding|nucleolus|cytoplasm|rRNA processing|mRNA polyadenylation|cell cycle|miRNA catabolic process|RNA 3'-end processing|TRAMP complex|negative regulation of telomere maintenance via telomerase|carbohydrate homeostasis|ncRNA polyadenylation|ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process|metal ion binding|cell division|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|telomerase RNA binding|guanylyltransferase activity|histone mRNA catabolic process|sno(s)RNA polyadenylation|RNA 3' uridylation|DNA biosynthetic process|positive regulation of 3'-UTR-mediated mRNA stabilization hsa03018 RNA degradation TENT5A 206.7474211 292.3073189 121.1875232 0.414589425 -1.270244777 0.018346096 0.586469295 2.652155948 1.146920214 55603 terminal nucleotidyltransferase 5A "GO:0003723,GO:0005515,GO:0048255,GO:1990817" RNA binding|protein binding|mRNA stabilization|RNA adenylyltransferase activity TENT5B 36.45206181 33.49354696 39.41057666 1.176661782 0.234699694 0.826016981 1 0.712145254 0.874049768 115572 terminal nucleotidyltransferase 5B "GO:0005515,GO:0048255,GO:1990817" protein binding|mRNA stabilization|RNA adenylyltransferase activity TENT5C 13.91246804 8.119647747 19.70528833 2.426864926 1.279093814 0.315905528 1 0.072732846 0.184116249 54855 terminal nucleotidyltransferase 5C "GO:0001701,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016032,GO:0048255,GO:1990817" in utero embryonic development|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|viral process|mRNA stabilization|RNA adenylyltransferase activity TEP1 783.3413805 778.4712277 788.2115332 1.012512094 0.017939141 0.964987252 1 3.656726155 3.861967257 7011 telomerase associated protein 1 "GO:0000722,GO:0000781,GO:0002039,GO:0003720,GO:0003723,GO:0005515,GO:0005524,GO:0005697,GO:0005737,GO:0006278,GO:0016363,GO:0019899,GO:0070034,GO:1990904" "telomere maintenance via recombination|chromosome, telomeric region|p53 binding|telomerase activity|RNA binding|protein binding|ATP binding|telomerase holoenzyme complex|cytoplasm|RNA-dependent DNA biosynthetic process|nuclear matrix|enzyme binding|telomerase RNA binding|ribonucleoprotein complex" TEPSIN 246.5521527 218.2155332 274.8887722 1.259712213 0.333094181 0.510772227 1 3.035387789 3.988425206 146705 TEPSIN adaptor related protein complex 4 accessory protein "GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0016607,GO:0030124,GO:0030662,GO:0031312,GO:0031965,GO:0032588" protein binding|cytoplasm|Golgi apparatus|cytosol|nuclear speck|AP-4 adaptor complex|coated vesicle membrane|extrinsic component of organelle membrane|nuclear membrane|trans-Golgi network membrane TERF1 794.5949708 806.8899949 782.2999467 0.969524906 -0.044650134 0.906746829 1 13.05210211 13.19943564 7013 telomeric repeat binding factor 1 "GO:0000723,GO:0000781,GO:0000783,GO:0001650,GO:0003677,GO:0003691,GO:0003720,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005819,GO:0007004,GO:0007049,GO:0008017,GO:0008156,GO:0008301,GO:0016233,GO:0016604,GO:0032211,GO:0032214,GO:0042162,GO:0042802,GO:0042803,GO:0051301,GO:0051974,GO:0061820,GO:0070187,GO:0071532,GO:0090656,GO:0098505,GO:1904357,GO:1904792,GO:1904850,GO:1904911,GO:1904914,GO:1905778,GO:1905839" "telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|fibrillar center|DNA binding|double-stranded telomeric DNA binding|telomerase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|spindle|telomere maintenance via telomerase|cell cycle|microtubule binding|negative regulation of DNA replication|DNA binding, bending|telomere capping|nuclear body|negative regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via semi-conservative replication|telomeric DNA binding|identical protein binding|protein homodimerization activity|cell division|negative regulation of telomerase activity|telomeric D-loop disassembly|shelterin complex|ankyrin repeat binding|t-circle formation|G-rich strand telomeric DNA binding|negative regulation of telomere maintenance via telomere lengthening|positive regulation of shelterin complex assembly|negative regulation of establishment of protein localization to telomere|negative regulation of establishment of RNA localization to telomere|negative regulation of establishment of protein-containing complex localization to telomere|negative regulation of exonuclease activity|negative regulation of telomeric D-loop disassembly" MYB TERF2 433.8251369 425.2665507 442.383723 1.040250455 0.05693092 0.898480849 1 7.174633759 7.784909728 7014 telomeric repeat binding factor 2 "GO:0000723,GO:0000781,GO:0000783,GO:0001673,GO:0001701,GO:0003691,GO:0003720,GO:0005515,GO:0005634,GO:0005654,GO:0006278,GO:0007049,GO:0008022,GO:0010628,GO:0010629,GO:0016233,GO:0016604,GO:0019899,GO:0030870,GO:0031627,GO:0031848,GO:0032204,GO:0032205,GO:0032206,GO:0032208,GO:0032210,GO:0032211,GO:0032214,GO:0042162,GO:0042803,GO:0044877,GO:0051000,GO:0061820,GO:0070187,GO:0070198,GO:0090398,GO:0098505,GO:0099087,GO:1903770,GO:1903824,GO:1904115,GO:1904354,GO:1904357,GO:1904430,GO:1905778,GO:1905839,GO:2000773" "telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|male germ cell nucleus|in utero embryonic development|double-stranded telomeric DNA binding|telomerase activity|protein binding|nucleus|nucleoplasm|RNA-dependent DNA biosynthetic process|cell cycle|protein C-terminus binding|positive regulation of gene expression|negative regulation of gene expression|telomere capping|nuclear body|enzyme binding|Mre11 complex|telomeric loop formation|protection from non-homologous end joining at telomere|regulation of telomere maintenance|negative regulation of telomere maintenance|positive regulation of telomere maintenance|negative regulation of telomere maintenance via recombination|regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via semi-conservative replication|telomeric DNA binding|protein homodimerization activity|protein-containing complex binding|positive regulation of nitric-oxide synthase activity|telomeric D-loop disassembly|shelterin complex|protein localization to chromosome, telomeric region|cellular senescence|G-rich strand telomeric DNA binding|anterograde axonal transport of messenger ribonucleoprotein complex|negative regulation of beta-galactosidase activity|negative regulation of telomere single strand break repair|axon cytoplasm|negative regulation of telomere capping|negative regulation of telomere maintenance via telomere lengthening|negative regulation of t-circle formation|negative regulation of exonuclease activity|negative regulation of telomeric D-loop disassembly|negative regulation of cellular senescence" TERF2IP 659.6300753 605.9287131 713.3314376 1.17725307 0.235424485 0.539662713 1 14.40082202 17.68369616 54386 TERF2 interacting protein "GO:0000228,GO:0000723,GO:0000781,GO:0000783,GO:0001933,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0007004,GO:0010569,GO:0010833,GO:0016233,GO:0016604,GO:0019902,GO:0030870,GO:0031848,GO:0032204,GO:0032205,GO:0033138,GO:0042162,GO:0043123,GO:0048239,GO:0051092,GO:0070187,GO:0070198,GO:0098505,GO:1901224,GO:1901985" "nuclear chromosome|telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|negative regulation of protein phosphorylation|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|telomere maintenance via telomerase|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomere lengthening|telomere capping|nuclear body|phosphatase binding|Mre11 complex|protection from non-homologous end joining at telomere|regulation of telomere maintenance|negative regulation of telomere maintenance|positive regulation of peptidyl-serine phosphorylation|telomeric DNA binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of DNA recombination at telomere|positive regulation of NF-kappaB transcription factor activity|shelterin complex|protein localization to chromosome, telomeric region|G-rich strand telomeric DNA binding|positive regulation of NIK/NF-kappaB signaling|positive regulation of protein acetylation" TERT 77.43901232 107.5853326 47.29269199 0.439583081 -1.185792235 0.109793051 1 1.349051141 0.618564956 7015 telomerase reverse transcriptase "GO:0000049,GO:0000333,GO:0000723,GO:0000781,GO:0000783,GO:0001172,GO:0001223,GO:0003677,GO:0003720,GO:0003721,GO:0003723,GO:0003964,GO:0003968,GO:0005515,GO:0005634,GO:0005654,GO:0005697,GO:0005730,GO:0005829,GO:0005886,GO:0006278,GO:0007004,GO:0007005,GO:0008022,GO:0010629,GO:0016605,GO:0016607,GO:0022616,GO:0030177,GO:0030422,GO:0031379,GO:0031647,GO:0032092,GO:0042162,GO:0042635,GO:0042645,GO:0042802,GO:0042803,GO:0043524,GO:0045766,GO:0046326,GO:0046686,GO:0046872,GO:0047485,GO:0051000,GO:0051087,GO:0062103,GO:0070034,GO:0070200,GO:0071456,GO:0071897,GO:0090399,GO:0098680,GO:1900087,GO:1902895,GO:1903620,GO:1903704,GO:1903799,GO:1904707,GO:1904751,GO:1904754,GO:1904837,GO:1990572,GO:2000352,GO:2000648,GO:2000773,GO:2001240" "tRNA binding|telomerase catalytic core complex|telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|transcription, RNA-templated|transcription coactivator binding|DNA binding|telomerase activity|telomerase RNA reverse transcriptase activity|RNA binding|RNA-directed DNA polymerase activity|RNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|telomerase holoenzyme complex|nucleolus|cytosol|plasma membrane|RNA-dependent DNA biosynthetic process|telomere maintenance via telomerase|mitochondrion organization|protein C-terminus binding|negative regulation of gene expression|PML body|nuclear speck|DNA strand elongation|positive regulation of Wnt signaling pathway|production of siRNA involved in RNA interference|RNA-directed RNA polymerase complex|regulation of protein stability|positive regulation of protein binding|telomeric DNA binding|positive regulation of hair cycle|mitochondrial nucleoid|identical protein binding|protein homodimerization activity|negative regulation of neuron apoptotic process|positive regulation of angiogenesis|positive regulation of glucose import|response to cadmium ion|metal ion binding|protein N-terminus binding|positive regulation of nitric-oxide synthase activity|chaperone binding|double-stranded RNA biosynthetic process|telomerase RNA binding|establishment of protein localization to telomere|cellular response to hypoxia|DNA biosynthetic process|replicative senescence|template-free RNA nucleotidyltransferase|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of transdifferentiation|negative regulation of production of siRNA involved in RNA interference|negative regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of protein localization to nucleolus|positive regulation of vascular associated smooth muscle cell migration|beta-catenin-TCF complex assembly|TERT-RMRP complex|negative regulation of endothelial cell apoptotic process|positive regulation of stem cell proliferation|negative regulation of cellular senescence|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa05165,hsa05166,hsa05200,hsa05225,hsa05226" Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Hepatocellular carcinoma|Gastric cancer TES 1486.382473 1388.459765 1584.305182 1.141052281 0.190364895 0.566925359 1 25.0251206 29.78500329 26136 testin LIM domain protein "GO:0003723,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005925,GO:0008270,GO:0008285,GO:0030054,GO:0032991,GO:0045296" RNA binding|protein binding|nucleus|cytosol|plasma membrane|focal adhesion|zinc ion binding|negative regulation of cell population proliferation|cell junction|protein-containing complex|cadherin binding TESC 4.552456082 8.119647747 0.985264417 0.121343246 -3.042834281 0.175274214 1 0.398866648 0.05048464 54997 tescalcin "GO:0000287,GO:0001726,GO:0004860,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006469,GO:0008285,GO:0008584,GO:0010628,GO:0015031,GO:0019212,GO:0030027,GO:0030219,GO:0030854,GO:0032417,GO:0032587,GO:0033628,GO:0042803,GO:0045654,GO:0045893,GO:0050821,GO:0051604,GO:0071300,GO:0072659" "magnesium ion binding|ruffle|protein kinase inhibitor activity|calcium ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|negative regulation of protein kinase activity|negative regulation of cell population proliferation|male gonad development|positive regulation of gene expression|protein transport|phosphatase inhibitor activity|lamellipodium|megakaryocyte differentiation|positive regulation of granulocyte differentiation|positive regulation of sodium:proton antiporter activity|ruffle membrane|regulation of cell adhesion mediated by integrin|protein homodimerization activity|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|protein stabilization|protein maturation|cellular response to retinoic acid|protein localization to plasma membrane" TESK1 1156.772678 947.9688745 1365.576481 1.440528817 0.526598521 0.126154762 1 18.97679022 28.5141636 7016 testis associated actin remodelling kinase 1 "GO:0001934,GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0007283,GO:0008022,GO:0018108,GO:0019901,GO:0030036,GO:0031410,GO:0031953,GO:0032880,GO:0032956,GO:0042326,GO:0046872,GO:0048471,GO:0051496,GO:0051650,GO:0071901,GO:0090521,GO:1900026,GO:1900182,GO:1902018" positive regulation of protein phosphorylation|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|spermatogenesis|protein C-terminus binding|peptidyl-tyrosine phosphorylation|protein kinase binding|actin cytoskeleton organization|cytoplasmic vesicle|negative regulation of protein autophosphorylation|regulation of protein localization|regulation of actin cytoskeleton organization|negative regulation of phosphorylation|metal ion binding|perinuclear region of cytoplasm|positive regulation of stress fiber assembly|establishment of vesicle localization|negative regulation of protein serine/threonine kinase activity|glomerular visceral epithelial cell migration|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of protein localization to nucleus|negative regulation of cilium assembly TESK2 322.2096719 204.0061496 440.4131942 2.158823128 1.110245049 0.017206154 0.570200991 3.364438876 7.576098885 10420 testis associated actin remodelling kinase 2 "GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0007283,GO:0016604,GO:0018108,GO:0030036,GO:0046872,GO:0048041" protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|spermatogenesis|nuclear body|peptidyl-tyrosine phosphorylation|actin cytoskeleton organization|metal ion binding|focal adhesion assembly TESMIN 68.78491664 54.80762229 82.76221099 1.510049287 0.594595639 0.442165864 1 0.481410461 0.758267734 9633 testis expressed metallothionein like protein "GO:0005634,GO:0005737,GO:0006355,GO:0006875,GO:0007275,GO:0007283,GO:0010038,GO:0030154,GO:0046872" "nucleus|cytoplasm|regulation of transcription, DNA-templated|cellular metal ion homeostasis|multicellular organism development|spermatogenesis|response to metal ion|cell differentiation|metal ion binding" TET1 271.4576681 337.9803375 204.9349986 0.606351837 -0.72177293 0.139698817 1 1.015755505 0.642435916 80312 tet methylcytosine dioxygenase 1 "GO:0001826,GO:0003677,GO:0005506,GO:0005634,GO:0006211,GO:0006325,GO:0006493,GO:0008270,GO:0008284,GO:0008327,GO:0019827,GO:0031062,GO:0045944,GO:0070579,GO:0070989,GO:0080111,GO:0090310" inner cell mass cell differentiation|DNA binding|iron ion binding|nucleus|5-methylcytosine catabolic process|chromatin organization|protein O-linked glycosylation|zinc ion binding|positive regulation of cell population proliferation|methyl-CpG binding|stem cell population maintenance|positive regulation of histone methylation|positive regulation of transcription by RNA polymerase II|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|negative regulation of DNA methylation-dependent heterochromatin assembly TET2 557.4770589 593.7492415 521.2048764 0.877819861 -0.188003184 0.638706325 1 2.695285871 2.467892095 54790 tet methylcytosine dioxygenase 2 "GO:0003677,GO:0005515,GO:0005634,GO:0006211,GO:0006493,GO:0007049,GO:0008198,GO:0008270,GO:0030099,GO:0045944,GO:0070579,GO:0070989,GO:0080111,GO:0080182" DNA binding|protein binding|nucleus|5-methylcytosine catabolic process|protein O-linked glycosylation|cell cycle|ferrous iron binding|zinc ion binding|myeloid cell differentiation|positive regulation of transcription by RNA polymerase II|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|histone H3-K4 trimethylation other TET3 631.6512383 646.5269519 616.7755248 0.953982696 -0.067964997 0.86407097 1 2.242453726 2.231412785 200424 tet methylcytosine dioxygenase 3 "GO:0001939,GO:0001940,GO:0005515,GO:0005634,GO:0005694,GO:0005737,GO:0006211,GO:0006493,GO:0008270,GO:0008327,GO:0044727,GO:0045944,GO:0070579,GO:0070989,GO:0080111,GO:0080182" female pronucleus|male pronucleus|protein binding|nucleus|chromosome|cytoplasm|5-methylcytosine catabolic process|protein O-linked glycosylation|zinc ion binding|methyl-CpG binding|DNA demethylation of male pronucleus|positive regulation of transcription by RNA polymerase II|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|histone H3-K4 trimethylation TEX10 1030.526458 1107.316961 953.7359552 0.861303483 -0.21540643 0.539736381 1 17.95188787 16.12806481 54881 testis expressed 10 "GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0006364,GO:0071339,GO:0097344" protein binding|nucleoplasm|nucleolus|mitochondrion|rRNA processing|MLL1 complex|Rix1 complex TEX14 12.46426297 10.14955968 14.77896625 1.456118956 0.542128219 0.716114088 1 0.097763293 0.148487059 56155 "testis expressed 14, intercellular bridge forming factor" "GO:0000776,GO:0000777,GO:0004672,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0007094,GO:0007140,GO:0008608,GO:0019901,GO:0030496,GO:0032091,GO:0032466,GO:0043063,GO:0045171,GO:0051301,GO:0051306,GO:0070062,GO:1990830" kinetochore|condensed chromosome kinetochore|protein kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|mitotic spindle assembly checkpoint|male meiotic nuclear division|attachment of spindle microtubules to kinetochore|protein kinase binding|midbody|negative regulation of protein binding|negative regulation of cytokinesis|intercellular bridge organization|intercellular bridge|cell division|mitotic sister chromatid separation|extracellular exosome|cellular response to leukemia inhibitory factor TEX15 29.57005667 34.50850292 24.63161041 0.713783802 -0.486440933 0.641011736 1 0.152294696 0.113388079 56154 "testis expressed 15, meiosis and synapsis associated" "GO:0005634,GO:0005737,GO:0006281,GO:0006306,GO:0007129,GO:0007140,GO:0007283,GO:0010529,GO:0010569,GO:0030154,GO:1990511" nucleus|cytoplasm|DNA repair|DNA methylation|homologous chromosome pairing at meiosis|male meiotic nuclear division|spermatogenesis|negative regulation of transposition|regulation of double-strand break repair via homologous recombination|cell differentiation|piRNA biosynthetic process TEX19 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.024224288 0.073585764 400629 testis expressed 19 "GO:0001890,GO:0005515,GO:0005634,GO:0005737,GO:0007131,GO:0007140,GO:0007283,GO:0008584,GO:0010529,GO:0030154,GO:0034584" placenta development|protein binding|nucleus|cytoplasm|reciprocal meiotic recombination|male meiotic nuclear division|spermatogenesis|male gonad development|negative regulation of transposition|cell differentiation|piRNA binding TEX2 1080.19868 1034.240132 1126.157228 1.088874038 0.122837071 0.725631841 1 3.998214953 4.541085842 55852 testis expressed 2 "GO:0003674,GO:0005783,GO:0005789,GO:0006665,GO:0006869,GO:0007165,GO:0008289,GO:0016021,GO:0031965" molecular_function|endoplasmic reticulum|endoplasmic reticulum membrane|sphingolipid metabolic process|lipid transport|signal transduction|lipid binding|integral component of membrane|nuclear membrane TEX22 12.92720362 8.119647747 17.7347595 2.184178434 1.12709072 0.39224396 1 0.144545348 0.329312459 647310 testis expressed 22 GO:0001669 acrosomal vesicle TEX261 2676.029135 2495.776726 2856.281544 1.144445941 0.194649317 0.54152601 1 37.5638296 44.84159735 113419 testis expressed 261 "GO:0006888,GO:0006897,GO:0030134,GO:0030173,GO:0030176,GO:0097020" endoplasmic reticulum to Golgi vesicle-mediated transport|endocytosis|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|COPII receptor activity TEX264 952.8702026 917.5201954 988.2202098 1.07705554 0.107092647 0.765237668 1 19.34602876 21.73431003 51368 "testis expressed 264, ER-phagy receptor" "GO:0000421,GO:0002576,GO:0005515,GO:0005576,GO:0005634,GO:0005657,GO:0005789,GO:0005829,GO:0016021,GO:0031093,GO:0038023,GO:0061709,GO:0106300" autophagosome membrane|platelet degranulation|protein binding|extracellular region|nucleus|replication fork|endoplasmic reticulum membrane|cytosol|integral component of membrane|platelet alpha granule lumen|signaling receptor activity|reticulophagy|protein-DNA covalent cross-linking repair TEX30 273.5375605 278.0979353 268.9771857 0.967203102 -0.048109223 0.929020839 1 4.810341309 4.852991186 93081 testis expressed 30 GO:0016787 hydrolase activity TEX48 4.044978098 7.104691779 0.985264417 0.138677996 -2.850189203 0.227217187 1 0.431447931 0.062409669 100505478 testis expressed 48 GO:0005515 protein binding TEX9 64.12581852 73.07682972 55.17480733 0.755024644 -0.405404361 0.614229597 1 0.906461824 0.713882236 374618 testis expressed 9 GO:0005515 protein binding TF 1.985374609 1.014955968 2.95579325 2.912237912 1.542128219 0.744169253 1 0.002421858 0.007356843 7018 transferrin "GO:0001895,GO:0002576,GO:0005515,GO:0005576,GO:0005615,GO:0005769,GO:0005770,GO:0005788,GO:0005886,GO:0005905,GO:0006826,GO:0006879,GO:0007015,GO:0007257,GO:0008198,GO:0008199,GO:0009925,GO:0009986,GO:0010008,GO:0016324,GO:0019731,GO:0030139,GO:0030316,GO:0030665,GO:0031232,GO:0031410,GO:0031647,GO:0031982,GO:0033572,GO:0034756,GO:0034774,GO:0034986,GO:0043687,GO:0044267,GO:0045178,GO:0045780,GO:0045893,GO:0048260,GO:0048471,GO:0055037,GO:0055072,GO:0060395,GO:0061024,GO:0070062,GO:0070371,GO:0071281,GO:0072562,GO:1990459,GO:1990712,GO:2000147" "retina homeostasis|platelet degranulation|protein binding|extracellular region|extracellular space|early endosome|late endosome|endoplasmic reticulum lumen|plasma membrane|clathrin-coated pit|iron ion transport|cellular iron ion homeostasis|actin filament organization|activation of JUN kinase activity|ferrous iron binding|ferric iron binding|basal plasma membrane|cell surface|endosome membrane|apical plasma membrane|antibacterial humoral response|endocytic vesicle|osteoclast differentiation|clathrin-coated vesicle membrane|extrinsic component of external side of plasma membrane|cytoplasmic vesicle|regulation of protein stability|vesicle|transferrin transport|regulation of iron ion transport|secretory granule lumen|iron chaperone activity|post-translational protein modification|cellular protein metabolic process|basal part of cell|positive regulation of bone resorption|positive regulation of transcription, DNA-templated|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|recycling endosome|iron ion homeostasis|SMAD protein signal transduction|membrane organization|extracellular exosome|ERK1 and ERK2 cascade|cellular response to iron ion|blood microparticle|transferrin receptor binding|HFE-transferrin receptor complex|positive regulation of cell motility" "hsa04066,hsa04216,hsa04978" HIF-1 signaling pathway|Ferroptosis|Mineral absorption TF family TFAM 1705.272993 1601.600518 1808.945469 1.129461091 0.175634572 0.591525069 1 16.1391596 19.01376494 7019 "transcription factor A, mitochondrial" "GO:0000976,GO:0001018,GO:0001223,GO:0003682,GO:0003700,GO:0003723,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0006390,GO:0006391,GO:0007005,GO:0008301,GO:0031072,GO:0032991,GO:0033108,GO:0034246,GO:0042645,GO:0043565,GO:0045893" "transcription regulatory region sequence-specific DNA binding|mitochondrial promoter sequence-specific DNA binding|transcription coactivator binding|chromatin binding|DNA-binding transcription factor activity|RNA binding|protein binding|nucleus|mitochondrion|mitochondrial matrix|cytosol|mitochondrial transcription|transcription initiation from mitochondrial promoter|mitochondrion organization|DNA binding, bending|heat shock protein binding|protein-containing complex|mitochondrial respiratory chain complex assembly|mitochondrial transcription factor activity|mitochondrial nucleoid|sequence-specific DNA binding|positive regulation of transcription, DNA-templated" "hsa04371,hsa05016" Apelin signaling pathway|Huntington disease TFAP2A 138.3769484 97.43577296 179.3181238 1.840372569 0.879997858 0.1491301 1 1.101512984 2.114517588 7020 transcription factor AP-2 alpha "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001822,GO:0003404,GO:0003409,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007605,GO:0008285,GO:0010628,GO:0010842,GO:0010944,GO:0021559,GO:0021623,GO:0030501,GO:0035115,GO:0042127,GO:0042472,GO:0042802,GO:0043066,GO:0043525,GO:0043565,GO:0045595,GO:0045892,GO:0045893,GO:0045944,GO:0048701,GO:0048856,GO:0060021,GO:0060349,GO:0061029,GO:0070172,GO:0071281,GO:1990837,GO:2000378" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|kidney development|optic vesicle morphogenesis|optic cup structural organization|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|sensory perception of sound|negative regulation of cell population proliferation|positive regulation of gene expression|retina layer formation|negative regulation of transcription by competitive promoter binding|trigeminal nerve development|oculomotor nerve formation|positive regulation of bone mineralization|embryonic forelimb morphogenesis|regulation of cell population proliferation|inner ear morphogenesis|identical protein binding|negative regulation of apoptotic process|positive regulation of neuron apoptotic process|sequence-specific DNA binding|regulation of cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic cranial skeleton morphogenesis|anatomical structure development|roof of mouth development|bone morphogenesis|eyelid development in camera-type eye|positive regulation of tooth mineralization|cellular response to iron ion|sequence-specific double-stranded DNA binding|negative regulation of reactive oxygen species metabolic process" AP_2 TFAP2C 1606.719582 1566.077059 1647.362104 1.051903605 0.073002504 0.825828976 1 27.7135843 30.40776999 7022 transcription factor AP-2 gamma "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006357,GO:0007267,GO:0008584,GO:0040029,GO:0042127,GO:0045944,GO:0048856,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|cell-cell signaling|male gonad development|regulation of gene expression, epigenetic|regulation of cell population proliferation|positive regulation of transcription by RNA polymerase II|anatomical structure development|sequence-specific double-stranded DNA binding" AP_2 TFAP2E 18.45007834 15.22433953 21.67581716 1.423760757 0.509706742 0.683341071 1 0.108860524 0.16166774 339488 transcription factor AP-2 epsilon "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005634,GO:0006357,GO:0042127,GO:0045944,GO:0048856,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|regulation of cell population proliferation|positive regulation of transcription by RNA polymerase II|anatomical structure development|sequence-specific double-stranded DNA binding" TFAP4 247.6062028 290.277407 204.9349986 0.705997069 -0.5022659 0.318551921 1 5.248670698 3.86516603 7023 transcription factor AP-4 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0006978,GO:0008285,GO:0017053,GO:0042803,GO:0042826,GO:0043065,GO:0043392,GO:0043565,GO:0043922,GO:0043923,GO:0045736,GO:0045892,GO:0045893,GO:0045944,GO:0065003,GO:0070888,GO:0071157,GO:0071549,GO:1901990,GO:1990837,GO:2001269" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of cell population proliferation|transcription repressor complex|protein homodimerization activity|histone deacetylase binding|positive regulation of apoptotic process|negative regulation of DNA binding|sequence-specific DNA binding|negative regulation by host of viral transcription|positive regulation by host of viral transcription|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein-containing complex assembly|E-box binding|negative regulation of cell cycle arrest|cellular response to dexamethasone stimulus|regulation of mitotic cell cycle phase transition|sequence-specific double-stranded DNA binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway" hsa05205 Proteoglycans in cancer bHLH TFB1M 248.712955 264.9035077 232.5224023 0.87776264 -0.188097228 0.713038703 1 1.960892742 1.795340636 51106 "transcription factor B1, mitochondrial" "GO:0000154,GO:0000179,GO:0003677,GO:0003723,GO:0005515,GO:0005759,GO:0006391,GO:0007005,GO:0031167,GO:0034246,GO:0042645" "rRNA modification|rRNA (adenine-N6,N6-)-dimethyltransferase activity|DNA binding|RNA binding|protein binding|mitochondrial matrix|transcription initiation from mitochondrial promoter|mitochondrion organization|rRNA methylation|mitochondrial transcription factor activity|mitochondrial nucleoid" TFB2M 350.8253935 409.0272553 292.6235317 0.715413283 -0.483151189 0.28398955 1 12.00219439 8.956402156 64216 "transcription factor B2, mitochondrial" "GO:0000179,GO:0003712,GO:0003723,GO:0005739,GO:0005759,GO:0006355,GO:0006390,GO:0006391,GO:0007005,GO:0031167,GO:0034246,GO:0042645" "rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription coregulator activity|RNA binding|mitochondrion|mitochondrial matrix|regulation of transcription, DNA-templated|mitochondrial transcription|transcription initiation from mitochondrial promoter|mitochondrion organization|rRNA methylation|mitochondrial transcription factor activity|mitochondrial nucleoid" TFCP2 790.7942061 917.5201954 664.0682168 0.723764142 -0.466408462 0.205419014 1 12.20624142 9.214991683 7024 transcription factor CP2 "GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0008134,GO:0032991,GO:0042789,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription factor binding|protein-containing complex|mRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TFCP2L1 6.419064483 1.014955968 11.823173 11.64895165 3.542128219 0.075977894 1 0.005029248 0.061109086 29842 transcription factor CP2 like 1 "GO:0000122,GO:0000785,GO:0000902,GO:0000978,GO:0000981,GO:0001228,GO:0002070,GO:0005634,GO:0005737,GO:0006357,GO:0007028,GO:0007431,GO:0008340,GO:0016020,GO:0045927,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|epithelial cell maturation|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|cytoplasm organization|salivary gland development|determination of adult lifespan|membrane|positive regulation of growth|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TFDP1 2015.997978 2232.90313 1799.092825 0.805719156 -0.31165104 0.333344278 1 37.20021919 31.26404142 7027 transcription factor Dp-1 "GO:0000083,GO:0000785,GO:0000977,GO:0000981,GO:0000987,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006357,GO:0006366,GO:0006977,GO:0008134,GO:0008544,GO:0019904,GO:0043276,GO:0045944,GO:0051091,GO:0070317,GO:0070345,GO:0090575,GO:1900087,GO:1900740,GO:2000278" "regulation of transcription involved in G1/S transition of mitotic cell cycle|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|transcription factor binding|epidermis development|protein domain specific binding|anoikis|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|negative regulation of G0 to G1 transition|negative regulation of fat cell proliferation|RNA polymerase II transcription regulator complex|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of DNA biosynthetic process" "hsa04110,hsa04350" Cell cycle|TGF-beta signaling pathway E2F TFDP2 876.4988484 714.5290017 1038.468695 1.453361155 0.539393252 0.135325793 1 3.460684061 5.246279578 7029 transcription factor Dp-2 "GO:0000083,GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0006977,GO:0007507,GO:0008134,GO:0019904,GO:0045892,GO:0045944,GO:0070317,GO:0072686,GO:0090575,GO:1900740" "regulation of transcription involved in G1/S transition of mitotic cell cycle|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|heart development|transcription factor binding|protein domain specific binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of G0 to G1 transition|mitotic spindle|RNA polymerase II transcription regulator complex|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" hsa04110 Cell cycle TFE3 3422.865998 2967.731252 3878.000744 1.306722346 0.385952628 0.225268035 1 46.4047911 63.25022425 7030 transcription factor binding to IGHM enhancer 3 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0002250,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006959,GO:0045670,GO:0045785,GO:0045893,GO:0045944,GO:0046983,GO:0090336,GO:0120163,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|adaptive immune response|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|humoral immune response|regulation of osteoclast differentiation|positive regulation of cell adhesion|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|positive regulation of brown fat cell differentiation|negative regulation of cold-induced thermogenesis|sequence-specific double-stranded DNA binding" "hsa04137,hsa05202,hsa05211" Mitophagy - animal|Transcriptional misregulation in cancer|Renal cell carcinoma bHLH TFEB 103.9223854 99.4656849 108.3790858 1.089612824 0.123815588 0.86639412 1 1.464840374 1.664862753 7942 transcription factor EB "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001892,GO:0002250,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005829,GO:0006355,GO:0006357,GO:0006914,GO:0006959,GO:0007040,GO:0009267,GO:0010468,GO:0010508,GO:0019899,GO:0032418,GO:0034198,GO:0045893,GO:0045944,GO:0046983,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|embryonic placenta development|adaptive immune response|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|lysosomal membrane|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|autophagy|humoral immune response|lysosome organization|cellular response to starvation|regulation of gene expression|positive regulation of autophagy|enzyme binding|lysosome localization|cellular response to amino acid starvation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|sequence-specific double-stranded DNA binding" hsa04137 Mitophagy - animal TFG 3020.365194 3033.703389 3007.026999 0.991206658 -0.012742216 0.969177754 1 65.27033747 67.48325133 10342 trafficking from ER to golgi regulator "GO:0000139,GO:0005515,GO:0005737,GO:0005829,GO:0006888,GO:0042802,GO:0043123,GO:0043231,GO:0048208,GO:0070971" Golgi membrane|protein binding|cytoplasm|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|COPII vesicle coating|endoplasmic reticulum exit site "hsa05200,hsa05216" Pathways in cancer|Thyroid cancer TFIP11 927.5205517 935.7894028 919.2517006 0.982327538 -0.025723951 0.945752056 1 7.829907812 8.022854161 24144 tuftelin interacting protein 11 "GO:0000390,GO:0000398,GO:0000781,GO:0003676,GO:0005515,GO:0005654,GO:0005681,GO:0005730,GO:0005737,GO:0006396,GO:0016607,GO:0031012,GO:0031214,GO:0031333,GO:0031848,GO:0032091,GO:0071008,GO:0071013,GO:1904876,GO:2001033" "spliceosomal complex disassembly|mRNA splicing, via spliceosome|chromosome, telomeric region|nucleic acid binding|protein binding|nucleoplasm|spliceosomal complex|nucleolus|cytoplasm|RNA processing|nuclear speck|extracellular matrix|biomineral tissue development|negative regulation of protein-containing complex assembly|protection from non-homologous end joining at telomere|negative regulation of protein binding|U2-type post-mRNA release spliceosomal complex|catalytic step 2 spliceosome|negative regulation of DNA ligase activity|negative regulation of double-strand break repair via nonhomologous end joining" TFPI 1440.476128 1045.404647 1835.547608 1.755824993 0.812149056 0.015252758 0.546920338 10.1780195 18.64062351 7035 tissue factor pathway inhibitor "GO:0004866,GO:0004867,GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0005901,GO:0007596,GO:0007598,GO:0009986,GO:0010951,GO:0030195,GO:0031090,GO:0031225,GO:0032355,GO:0071222,GO:0071347,GO:0071383" "endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|caveola|blood coagulation|blood coagulation, extrinsic pathway|cell surface|negative regulation of endopeptidase activity|negative regulation of blood coagulation|organelle membrane|anchored component of membrane|response to estradiol|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to steroid hormone stimulus" hsa04610 Complement and coagulation cascades TFPI2 31375.20281 20271.71556 42478.69005 2.095465968 1.067271091 0.007107237 0.341973728 465.1974982 1016.796194 7980 tissue factor pathway inhibitor 2 "GO:0004867,GO:0005201,GO:0005615,GO:0007596,GO:0010951,GO:0031012" serine-type endopeptidase inhibitor activity|extracellular matrix structural constituent|extracellular space|blood coagulation|negative regulation of endopeptidase activity|extracellular matrix TFPT 484.0978705 494.2835566 473.9121844 0.958786061 -0.06071916 0.887595799 1 20.53627433 20.53805434 29844 TCF3 fusion partner "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006310,GO:0016579,GO:0031011,GO:0043065,GO:0097190" DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|DNA recombination|protein deubiquitination|Ino80 complex|positive regulation of apoptotic process|apoptotic signaling pathway TFRC 5878.427254 6658.111153 5098.743356 0.765794268 -0.384971233 0.2350417 1 45.80410778 36.58747754 7037 transferrin receptor "GO:0001558,GO:0001618,GO:0001934,GO:0003723,GO:0003725,GO:0004998,GO:0005515,GO:0005576,GO:0005615,GO:0005768,GO:0005769,GO:0005886,GO:0005887,GO:0005905,GO:0006826,GO:0006879,GO:0009897,GO:0009986,GO:0010008,GO:0010628,GO:0010637,GO:0016020,GO:0016323,GO:0019901,GO:0030316,GO:0030665,GO:0030890,GO:0031334,GO:0031410,GO:0031623,GO:0033138,GO:0033572,GO:0035556,GO:0035690,GO:0042102,GO:0042127,GO:0042470,GO:0042802,GO:0042803,GO:0043066,GO:0043123,GO:0043231,GO:0044877,GO:0045780,GO:0045830,GO:0046718,GO:0048471,GO:0051092,GO:0055037,GO:0061024,GO:0070062,GO:0072562,GO:0150104,GO:1900182,GO:1903561,GO:1990712,GO:1990830" regulation of cell growth|virus receptor activity|positive regulation of protein phosphorylation|RNA binding|double-stranded RNA binding|transferrin receptor activity|protein binding|extracellular region|extracellular space|endosome|early endosome|plasma membrane|integral component of plasma membrane|clathrin-coated pit|iron ion transport|cellular iron ion homeostasis|external side of plasma membrane|cell surface|endosome membrane|positive regulation of gene expression|negative regulation of mitochondrial fusion|membrane|basolateral plasma membrane|protein kinase binding|osteoclast differentiation|clathrin-coated vesicle membrane|positive regulation of B cell proliferation|positive regulation of protein-containing complex assembly|cytoplasmic vesicle|receptor internalization|positive regulation of peptidyl-serine phosphorylation|transferrin transport|intracellular signal transduction|cellular response to drug|positive regulation of T cell proliferation|regulation of cell population proliferation|melanosome|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|protein-containing complex binding|positive regulation of bone resorption|positive regulation of isotype switching|viral entry into host cell|perinuclear region of cytoplasm|positive regulation of NF-kappaB transcription factor activity|recycling endosome|membrane organization|extracellular exosome|blood microparticle|transport across blood-brain barrier|positive regulation of protein localization to nucleus|extracellular vesicle|HFE-transferrin receptor complex|cellular response to leukemia inhibitory factor "hsa04066,hsa04144,hsa04145,hsa04216,hsa04640" HIF-1 signaling pathway|Endocytosis|Phagosome|Ferroptosis|Hematopoietic cell lineage TGDS 180.7203077 196.9014579 164.5391576 0.83564215 -0.259042831 0.647102401 1 4.998678804 4.357039518 23483 "TDP-glucose 4,6-dehydratase" "GO:0005515,GO:0008460,GO:0009225" "protein binding|dTDP-glucose 4,6-dehydratase activity|nucleotide-sugar metabolic process" TGFA 359.7830856 583.5996818 135.9664895 0.232979033 -2.10172797 6.40E-06 0.001769342 6.748234034 1.639920911 7039 transforming growth factor alpha "GO:0000139,GO:0000165,GO:0000187,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005789,GO:0005886,GO:0006357,GO:0006888,GO:0007165,GO:0007173,GO:0008083,GO:0008284,GO:0009986,GO:0012507,GO:0016021,GO:0016323,GO:0030665,GO:0031410,GO:0033116,GO:0035556,GO:0042059,GO:0045741,GO:0045840,GO:0048208,GO:0048471,GO:0050679,GO:0051781,GO:0051897,GO:0061024" Golgi membrane|MAPK cascade|activation of MAPK activity|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum membrane|plasma membrane|regulation of transcription by RNA polymerase II|endoplasmic reticulum to Golgi vesicle-mediated transport|signal transduction|epidermal growth factor receptor signaling pathway|growth factor activity|positive regulation of cell population proliferation|cell surface|ER to Golgi transport vesicle membrane|integral component of membrane|basolateral plasma membrane|clathrin-coated vesicle membrane|cytoplasmic vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|intracellular signal transduction|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitotic nuclear division|COPII vesicle coating|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|positive regulation of cell division|positive regulation of protein kinase B signaling|membrane organization "hsa01521,hsa04010,hsa04012,hsa04014,hsa04151,hsa04915,hsa05200,hsa05210,hsa05211,hsa05212,hsa05214,hsa05215,hsa05223,hsa05225" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Estrogen signaling pathway|Pathways in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Glioma|Prostate cancer|Non-small cell lung cancer|Hepatocellular carcinoma TGFB1 1797.992761 2147.646829 1448.338692 0.674384015 -0.568357754 0.080829775 1 51.72170017 36.38278918 7040 transforming growth factor beta 1 "GO:0000165,GO:0001570,GO:0001837,GO:0001843,GO:0001933,GO:0001934,GO:0002062,GO:0002244,GO:0002248,GO:0002576,GO:0003179,GO:0003180,GO:0003823,GO:0005114,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005796,GO:0005886,GO:0005902,GO:0006468,GO:0006611,GO:0006754,GO:0006796,GO:0006954,GO:0007050,GO:0007173,GO:0007179,GO:0007182,GO:0007183,GO:0007435,GO:0007507,GO:0008083,GO:0008284,GO:0008285,GO:0009611,GO:0009986,GO:0010575,GO:0010628,GO:0010629,GO:0010716,GO:0010718,GO:0010742,GO:0010763,GO:0010800,GO:0010862,GO:0010936,GO:0014008,GO:0016202,GO:0016477,GO:0017015,GO:0019221,GO:0019899,GO:0021915,GO:0022408,GO:0030214,GO:0030308,GO:0030334,GO:0030335,GO:0030501,GO:0030509,GO:0030512,GO:0031012,GO:0031093,GO:0031293,GO:0031334,GO:0031663,GO:0032270,GO:0032355,GO:0032570,GO:0032740,GO:0032801,GO:0032930,GO:0032967,GO:0033138,GO:0034713,GO:0034714,GO:0035307,GO:0042127,GO:0042306,GO:0042307,GO:0042802,GO:0043117,GO:0043406,GO:0043491,GO:0043536,GO:0043537,GO:0043552,GO:0043932,GO:0045216,GO:0045596,GO:0045599,GO:0045662,GO:0045786,GO:0045892,GO:0045893,GO:0045918,GO:0045930,GO:0045944,GO:0048298,GO:0048535,GO:0048642,GO:0050680,GO:0050714,GO:0050731,GO:0050900,GO:0050921,GO:0051098,GO:0051101,GO:0051781,GO:0051897,GO:0055010,GO:0060312,GO:0060389,GO:0060390,GO:0060391,GO:0060395,GO:0060965,GO:0062023,GO:0070168,GO:0070374,GO:0070723,GO:0071407,GO:0071560,GO:0072562,GO:0085029,GO:0090263,GO:0097191,GO:1900126,GO:1900182,GO:1901203,GO:1901666,GO:1902893,GO:1902895,GO:1903077,GO:1903799,GO:1903800,GO:1905005,GO:1905313,GO:1990402,GO:2000679,GO:2000727" "MAPK cascade|vasculogenesis|epithelial to mesenchymal transition|neural tube closure|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|chondrocyte differentiation|hematopoietic progenitor cell differentiation|connective tissue replacement involved in inflammatory response wound healing|platelet degranulation|heart valve morphogenesis|aortic valve morphogenesis|antigen binding|type II transforming growth factor beta receptor binding|cytokine activity|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|Golgi lumen|plasma membrane|microvillus|protein phosphorylation|protein export from nucleus|ATP biosynthetic process|phosphate-containing compound metabolic process|inflammatory response|cell cycle arrest|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|SMAD protein complex assembly|salivary gland morphogenesis|heart development|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to wounding|cell surface|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|negative regulation of gene expression|negative regulation of extracellular matrix disassembly|positive regulation of epithelial to mesenchymal transition|macrophage derived foam cell differentiation|positive regulation of fibroblast migration|positive regulation of peptidyl-threonine phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of macrophage cytokine production|positive regulation of microglia differentiation|regulation of striated muscle tissue development|cell migration|regulation of transforming growth factor beta receptor signaling pathway|cytokine-mediated signaling pathway|enzyme binding|neural tube development|negative regulation of cell-cell adhesion|hyaluronan catabolic process|negative regulation of cell growth|regulation of cell migration|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|platelet alpha granule lumen|membrane protein intracellular domain proteolysis|positive regulation of protein-containing complex assembly|lipopolysaccharide-mediated signaling pathway|positive regulation of cellular protein metabolic process|response to estradiol|response to progesterone|positive regulation of interleukin-17 production|receptor catabolic process|positive regulation of superoxide anion generation|positive regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding|positive regulation of protein dephosphorylation|regulation of cell population proliferation|regulation of protein import into nucleus|positive regulation of protein import into nucleus|identical protein binding|positive regulation of vascular permeability|positive regulation of MAP kinase activity|protein kinase B signaling|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|ossification involved in bone remodeling|cell-cell junction organization|negative regulation of cell differentiation|negative regulation of fat cell differentiation|negative regulation of myoblast differentiation|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of cytolysis|negative regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|positive regulation of isotype switching to IgA isotypes|lymph node development|negative regulation of skeletal muscle tissue development|negative regulation of epithelial cell proliferation|positive regulation of protein secretion|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|positive regulation of chemotaxis|regulation of binding|regulation of DNA binding|positive regulation of cell division|positive regulation of protein kinase B signaling|ventricular cardiac muscle tissue morphogenesis|regulation of blood vessel remodeling|pathway-restricted SMAD protein phosphorylation|regulation of SMAD protein signal transduction|positive regulation of SMAD protein signal transduction|SMAD protein signal transduction|negative regulation of gene silencing by miRNA|collagen-containing extracellular matrix|negative regulation of biomineral tissue development|positive regulation of ERK1 and ERK2 cascade|response to cholesterol|cellular response to organic cyclic compound|cellular response to transforming growth factor beta stimulus|blood microparticle|extracellular matrix assembly|positive regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|negative regulation of hyaluronan biosynthetic process|positive regulation of protein localization to nucleus|positive regulation of extracellular matrix assembly|positive regulation of NAD+ ADP-ribosyltransferase activity|regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of protein localization to plasma membrane|negative regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of production of miRNAs involved in gene silencing by miRNA|regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|transforming growth factor beta receptor signaling pathway involved in heart development|embryonic liver development|positive regulation of transcription regulatory region DNA binding|positive regulation of cardiac muscle cell differentiation" "hsa04010,hsa04060,hsa04068,hsa04110,hsa04218,hsa04350,hsa04380,hsa04390,hsa04659,hsa04672,hsa04926,hsa04932,hsa04933,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05166,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321,hsa05323,hsa05410,hsa05414" MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Osteoclast differentiation|Hippo signaling pathway|Th17 cell differentiation|Intestinal immune network for IgA production|Relaxin signaling pathway|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Chagas disease|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease|Rheumatoid arthritis|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TGFB1I1 1991.175102 1647.273537 2335.076667 1.417540327 0.503389778 0.118772351 1 42.91594311 63.45560853 7041 transforming growth factor beta 1 induced transcript 1 "GO:0003712,GO:0003713,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007155,GO:0008285,GO:0009408,GO:0010718,GO:0016055,GO:0016331,GO:0016363,GO:0030511,GO:0030512,GO:0030579,GO:0030855,GO:0045165,GO:0045599,GO:0045893,GO:0046872,GO:0048495,GO:0050681,GO:0062023,GO:0070411" "transcription coregulator activity|transcription coactivator activity|protein binding|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell adhesion|negative regulation of cell population proliferation|response to heat|positive regulation of epithelial to mesenchymal transition|Wnt signaling pathway|morphogenesis of embryonic epithelium|nuclear matrix|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process|epithelial cell differentiation|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|metal ion binding|Roundabout binding|androgen receptor binding|collagen-containing extracellular matrix|I-SMAD binding" TGFB2 201.6780844 215.1706653 188.1855036 0.874587172 -0.193325908 0.725162593 1 1.830919879 1.670276507 7042 transforming growth factor beta 2 "GO:0000902,GO:0001501,GO:0001540,GO:0001654,GO:0001666,GO:0001822,GO:0001837,GO:0001843,GO:0001942,GO:0002576,GO:0003007,GO:0003148,GO:0003149,GO:0003179,GO:0003181,GO:0003184,GO:0003203,GO:0003215,GO:0003222,GO:0003274,GO:0003289,GO:0003407,GO:0005102,GO:0005114,GO:0005125,GO:0005160,GO:0005515,GO:0005576,GO:0005615,GO:0006468,GO:0007050,GO:0007179,GO:0007435,GO:0007507,GO:0008083,GO:0008219,GO:0008284,GO:0008285,GO:0008347,GO:0008584,GO:0009611,GO:0009792,GO:0010002,GO:0010629,GO:0010634,GO:0010693,GO:0010718,GO:0010862,GO:0010936,GO:0014068,GO:0016477,GO:0016525,GO:0030097,GO:0030199,GO:0030307,GO:0030308,GO:0030326,GO:0030424,GO:0030509,GO:0030593,GO:0031069,GO:0031093,GO:0032147,GO:0032570,GO:0032874,GO:0032909,GO:0033630,GO:0034714,GO:0035910,GO:0042060,GO:0042127,GO:0042416,GO:0042476,GO:0042493,GO:0042704,GO:0042803,GO:0043025,GO:0043525,GO:0045216,GO:0045726,GO:0045747,GO:0045778,GO:0045787,GO:0045823,GO:0046580,GO:0048103,GO:0048566,GO:0048666,GO:0048699,GO:0048839,GO:0050680,GO:0050714,GO:0050778,GO:0051781,GO:0051794,GO:0051795,GO:0051891,GO:0060038,GO:0060065,GO:0060317,GO:0060389,GO:0060395,GO:0060412,GO:0060413,GO:0061626,GO:0062009,GO:0062023,GO:0097191,GO:1902256,GO:1902895,GO:1903659,GO:1903701,GO:1904888,GO:1905006,GO:1905007" cell morphogenesis|skeletal system development|amyloid-beta binding|eye development|response to hypoxia|kidney development|epithelial to mesenchymal transition|neural tube closure|hair follicle development|platelet degranulation|heart morphogenesis|outflow tract septum morphogenesis|membranous septum morphogenesis|heart valve morphogenesis|atrioventricular valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|endocardial cushion fusion|atrial septum primum morphogenesis|neural retina development|signaling receptor binding|type II transforming growth factor beta receptor binding|cytokine activity|transforming growth factor beta receptor binding|protein binding|extracellular region|extracellular space|protein phosphorylation|cell cycle arrest|transforming growth factor beta receptor signaling pathway|salivary gland morphogenesis|heart development|growth factor activity|cell death|positive regulation of cell population proliferation|negative regulation of cell population proliferation|glial cell migration|male gonad development|response to wounding|embryo development ending in birth or egg hatching|cardioblast differentiation|negative regulation of gene expression|positive regulation of epithelial cell migration|negative regulation of alkaline phosphatase activity|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of macrophage cytokine production|positive regulation of phosphatidylinositol 3-kinase signaling|cell migration|negative regulation of angiogenesis|hemopoiesis|collagen fibril organization|positive regulation of cell growth|negative regulation of cell growth|embryonic limb morphogenesis|axon|BMP signaling pathway|neutrophil chemotaxis|hair follicle morphogenesis|platelet alpha granule lumen|activation of protein kinase activity|response to progesterone|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor beta2 production|positive regulation of cell adhesion mediated by integrin|type III transforming growth factor beta receptor binding|ascending aorta morphogenesis|wound healing|regulation of cell population proliferation|dopamine biosynthetic process|odontogenesis|response to drug|uterine wall breakdown|protein homodimerization activity|neuronal cell body|positive regulation of neuron apoptotic process|cell-cell junction organization|positive regulation of integrin biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of ossification|positive regulation of cell cycle|positive regulation of heart contraction|negative regulation of Ras protein signal transduction|somatic stem cell division|embryonic digestive tract development|neuron development|generation of neurons|inner ear development|negative regulation of epithelial cell proliferation|positive regulation of protein secretion|positive regulation of immune response|positive regulation of cell division|regulation of timing of catagen|positive regulation of timing of catagen|positive regulation of cardioblast differentiation|cardiac muscle cell proliferation|uterus development|cardiac epithelial to mesenchymal transition|pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|ventricular septum morphogenesis|atrial septum morphogenesis|pharyngeal arch artery morphogenesis|secondary palate development|collagen-containing extracellular matrix|extrinsic apoptotic signaling pathway|regulation of apoptotic process involved in outflow tract morphogenesis|positive regulation of pri-miRNA transcription by RNA polymerase II|regulation of complement-dependent cytotoxicity|substantia propria of cornea development|cranial skeletal system development|negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation "hsa04010,hsa04060,hsa04068,hsa04110,hsa04218,hsa04350,hsa04380,hsa04390,hsa04933,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05166,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321,hsa05323,hsa05410,hsa05414" MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Osteoclast differentiation|Hippo signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Chagas disease|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease|Rheumatoid arthritis|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TGFB3 58.25876935 76.12169763 40.39584108 0.530674464 -0.914100967 0.259837266 1 0.98727156 0.546488146 7043 transforming growth factor beta 3 "GO:0000187,GO:0001666,GO:0001701,GO:0002576,GO:0005114,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005886,GO:0007179,GO:0007435,GO:0007565,GO:0007568,GO:0008083,GO:0008284,GO:0008285,GO:0009986,GO:0010718,GO:0010862,GO:0010936,GO:0030315,GO:0030501,GO:0030509,GO:0030512,GO:0030879,GO:0031093,GO:0032570,GO:0032967,GO:0034616,GO:0034713,GO:0034714,GO:0042060,GO:0042127,GO:0042476,GO:0042704,GO:0042802,GO:0043025,GO:0043065,GO:0043231,GO:0043524,GO:0043627,GO:0043932,GO:0044877,GO:0045216,GO:0045893,GO:0045944,GO:0048286,GO:0048565,GO:0048702,GO:0048839,GO:0050431,GO:0050714,GO:0051491,GO:0051496,GO:0051781,GO:0060325,GO:0060364,GO:0060391,GO:0060395,GO:0062009,GO:0062023,GO:0070483,GO:1904706,GO:1905005,GO:1905075" "activation of MAPK activity|response to hypoxia|in utero embryonic development|platelet degranulation|type II transforming growth factor beta receptor binding|cytokine activity|protein binding|extracellular region|extracellular space|nucleus|plasma membrane|transforming growth factor beta receptor signaling pathway|salivary gland morphogenesis|female pregnancy|aging|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|cell surface|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of macrophage cytokine production|T-tubule|positive regulation of bone mineralization|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|mammary gland development|platelet alpha granule lumen|response to progesterone|positive regulation of collagen biosynthetic process|response to laminar fluid shear stress|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding|wound healing|regulation of cell population proliferation|odontogenesis|uterine wall breakdown|identical protein binding|neuronal cell body|positive regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|response to estrogen|ossification involved in bone remodeling|protein-containing complex binding|cell-cell junction organization|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lung alveolus development|digestive tract development|embryonic neurocranium morphogenesis|inner ear development|transforming growth factor beta binding|positive regulation of protein secretion|positive regulation of filopodium assembly|positive regulation of stress fiber assembly|positive regulation of cell division|face morphogenesis|frontal suture morphogenesis|positive regulation of SMAD protein signal transduction|SMAD protein signal transduction|secondary palate development|collagen-containing extracellular matrix|detection of hypoxia|negative regulation of vascular associated smooth muscle cell proliferation|regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of tight junction disassembly" "hsa04010,hsa04060,hsa04068,hsa04110,hsa04218,hsa04350,hsa04390,hsa04933,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05166,hsa05200,hsa05210,hsa05211,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321,hsa05323,hsa05410,hsa05414" MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Hippo signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Chagas disease|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease|Rheumatoid arthritis|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TGFBI 706.0263315 982.4773774 429.5752856 0.437236821 -1.193513194 0.001738593 0.130192789 18.34771873 8.367866289 7045 transforming growth factor beta induced "GO:0001525,GO:0002062,GO:0005178,GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005604,GO:0005615,GO:0005802,GO:0005886,GO:0007155,GO:0007162,GO:0007601,GO:0008283,GO:0030198,GO:0031012,GO:0042802,GO:0044267,GO:0050839,GO:0050840,GO:0050896,GO:0062023,GO:0070062" angiogenesis|chondrocyte differentiation|integrin binding|extracellular matrix structural constituent|protein binding|collagen binding|extracellular region|basement membrane|extracellular space|trans-Golgi network|plasma membrane|cell adhesion|negative regulation of cell adhesion|visual perception|cell population proliferation|extracellular matrix organization|extracellular matrix|identical protein binding|cellular protein metabolic process|cell adhesion molecule binding|extracellular matrix binding|response to stimulus|collagen-containing extracellular matrix|extracellular exosome TGFBR1 499.8566579 561.2706505 438.4426654 0.781160862 -0.356308426 0.38385663 1 4.644074237 3.784038613 7046 transforming growth factor beta receptor 1 "GO:0000186,GO:0001501,GO:0001701,GO:0001822,GO:0001824,GO:0001837,GO:0001937,GO:0001938,GO:0002088,GO:0003222,GO:0003223,GO:0003342,GO:0004672,GO:0004674,GO:0005024,GO:0005025,GO:0005114,GO:0005515,GO:0005524,GO:0005634,GO:0005768,GO:0005886,GO:0005923,GO:0006355,GO:0006468,GO:0006915,GO:0007050,GO:0007165,GO:0007179,GO:0007399,GO:0007507,GO:0008284,GO:0008354,GO:0008584,GO:0009791,GO:0009952,GO:0009986,GO:0010628,GO:0010717,GO:0010718,GO:0010862,GO:0016361,GO:0016579,GO:0018105,GO:0018107,GO:0019838,GO:0030199,GO:0030307,GO:0030335,GO:0030512,GO:0031396,GO:0032331,GO:0032924,GO:0035556,GO:0042060,GO:0042118,GO:0043062,GO:0043235,GO:0043393,GO:0043542,GO:0045121,GO:0045893,GO:0046332,GO:0046872,GO:0048179,GO:0048185,GO:0048538,GO:0048663,GO:0048701,GO:0048705,GO:0048762,GO:0048844,GO:0048870,GO:0050431,GO:0051272,GO:0051491,GO:0051496,GO:0051897,GO:0060017,GO:0060021,GO:0060037,GO:0060043,GO:0060317,GO:0060389,GO:0060391,GO:0060412,GO:0060978,GO:0060982,GO:0070411,GO:0070723,GO:0071363,GO:0071560,GO:1905007,GO:1905075,GO:1905223,GO:2001235,GO:2001237" "activation of MAPKK activity|skeletal system development|in utero embryonic development|kidney development|blastocyst development|epithelial to mesenchymal transition|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|lens development in camera-type eye|ventricular trabecula myocardium morphogenesis|ventricular compact myocardium morphogenesis|proepicardium development|protein kinase activity|protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding|protein binding|ATP binding|nucleus|endosome|plasma membrane|bicellular tight junction|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|cell cycle arrest|signal transduction|transforming growth factor beta receptor signaling pathway|nervous system development|heart development|positive regulation of cell population proliferation|germ cell migration|male gonad development|post-embryonic development|anterior/posterior pattern specification|cell surface|positive regulation of gene expression|regulation of epithelial to mesenchymal transition|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|activin receptor activity, type I|protein deubiquitination|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|growth factor binding|collagen fibril organization|positive regulation of cell growth|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of protein ubiquitination|negative regulation of chondrocyte differentiation|activin receptor signaling pathway|intracellular signal transduction|wound healing|endothelial cell activation|extracellular structure organization|receptor complex|regulation of protein binding|endothelial cell migration|membrane raft|positive regulation of transcription, DNA-templated|SMAD binding|metal ion binding|activin receptor complex|activin binding|thymus development|neuron fate commitment|embryonic cranial skeleton morphogenesis|skeletal system morphogenesis|mesenchymal cell differentiation|artery morphogenesis|cell motility|transforming growth factor beta binding|positive regulation of cellular component movement|positive regulation of filopodium assembly|positive regulation of stress fiber assembly|positive regulation of protein kinase B signaling|parathyroid gland development|roof of mouth development|pharyngeal system development|regulation of cardiac muscle cell proliferation|cardiac epithelial to mesenchymal transition|pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein signal transduction|ventricular septum morphogenesis|angiogenesis involved in coronary vascular morphogenesis|coronary artery morphogenesis|I-SMAD binding|response to cholesterol|cellular response to growth factor stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of tight junction disassembly|epicardium morphogenesis|positive regulation of apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway" "hsa04010,hsa04060,hsa04068,hsa04144,hsa04218,hsa04350,hsa04371,hsa04380,hsa04390,hsa04520,hsa04659,hsa04926,hsa04933,hsa05142,hsa05161,hsa05166,hsa05200,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226" MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Endocytosis|Cellular senescence|TGF-beta signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Hippo signaling pathway|Adherens junction|Th17 cell differentiation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer TGFBR2 10235.30512 11510.61564 8959.994604 0.778411415 -0.361395229 0.284093637 1 87.36281658 70.93355938 7048 transforming growth factor beta receptor 2 "GO:0001568,GO:0001569,GO:0001570,GO:0001666,GO:0001701,GO:0001947,GO:0002053,GO:0002088,GO:0002651,GO:0002663,GO:0002666,GO:0003148,GO:0003149,GO:0003151,GO:0003181,GO:0003186,GO:0003214,GO:0003274,GO:0003430,GO:0004674,GO:0004675,GO:0005024,GO:0005026,GO:0005515,GO:0005524,GO:0005539,GO:0005829,GO:0005886,GO:0005887,GO:0005901,GO:0006468,GO:0006898,GO:0006915,GO:0007179,GO:0007182,GO:0007219,GO:0007224,GO:0007369,GO:0007420,GO:0007507,GO:0007566,GO:0007568,GO:0007584,GO:0008284,GO:0009612,GO:0009749,GO:0009897,GO:0010468,GO:0010634,GO:0010718,GO:0016021,GO:0017002,GO:0018105,GO:0018107,GO:0030512,GO:0031100,GO:0031435,GO:0032147,GO:0032924,GO:0034713,GO:0035162,GO:0042060,GO:0042127,GO:0042493,GO:0043011,GO:0043235,GO:0043415,GO:0043627,GO:0045121,GO:0045766,GO:0046332,GO:0046872,GO:0048185,GO:0048545,GO:0048565,GO:0048661,GO:0048701,GO:0050431,GO:0051138,GO:0060044,GO:0060389,GO:0060412,GO:0060434,GO:0060440,GO:0060443,GO:0060463,GO:0062009,GO:0070723,GO:0071363,GO:1905007,GO:1905315,GO:1905316,GO:1905317,GO:1990086,GO:1990428,GO:2000379,GO:2000563" "blood vessel development|branching involved in blood vessel morphogenesis|vasculogenesis|response to hypoxia|in utero embryonic development|heart looping|positive regulation of mesenchymal cell proliferation|lens development in camera-type eye|positive regulation of tolerance induction to self antigen|positive regulation of B cell tolerance induction|positive regulation of T cell tolerance induction|outflow tract septum morphogenesis|membranous septum morphogenesis|outflow tract morphogenesis|atrioventricular valve morphogenesis|tricuspid valve morphogenesis|cardiac left ventricle morphogenesis|endocardial cushion fusion|growth plate cartilage chondrocyte growth|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta receptor activity, type II|protein binding|ATP binding|glycosaminoglycan binding|cytosol|plasma membrane|integral component of plasma membrane|caveola|protein phosphorylation|receptor-mediated endocytosis|apoptotic process|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|Notch signaling pathway|smoothened signaling pathway|gastrulation|brain development|heart development|embryo implantation|aging|response to nutrient|positive regulation of cell population proliferation|response to mechanical stimulus|response to glucose|external side of plasma membrane|regulation of gene expression|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|integral component of membrane|activin-activated receptor activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|negative regulation of transforming growth factor beta receptor signaling pathway|animal organ regeneration|mitogen-activated protein kinase kinase kinase binding|activation of protein kinase activity|activin receptor signaling pathway|type I transforming growth factor beta receptor binding|embryonic hemopoiesis|wound healing|regulation of cell population proliferation|response to drug|myeloid dendritic cell differentiation|receptor complex|positive regulation of skeletal muscle tissue regeneration|response to estrogen|membrane raft|positive regulation of angiogenesis|SMAD binding|metal ion binding|activin binding|response to steroid hormone|digestive tract development|positive regulation of smooth muscle cell proliferation|embryonic cranial skeleton morphogenesis|transforming growth factor beta binding|positive regulation of NK T cell differentiation|negative regulation of cardiac muscle cell proliferation|pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|bronchus morphogenesis|trachea formation|mammary gland morphogenesis|lung lobe morphogenesis|secondary palate development|response to cholesterol|cellular response to growth factor stimulus|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|cell proliferation involved in endocardial cushion morphogenesis|superior endocardial cushion morphogenesis|inferior endocardial cushion morphogenesis|lens fiber cell apoptotic process|miRNA transport|positive regulation of reactive oxygen species metabolic process|positive regulation of CD4-positive, alpha-beta T cell proliferation" "hsa04010,hsa04060,hsa04068,hsa04144,hsa04218,hsa04350,hsa04380,hsa04390,hsa04520,hsa04659,hsa04926,hsa04933,hsa05142,hsa05161,hsa05166,hsa05200,hsa05202,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226" MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Endocytosis|Cellular senescence|TGF-beta signaling pathway|Osteoclast differentiation|Hippo signaling pathway|Adherens junction|Th17 cell differentiation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer TGFBR3 213.7833272 234.4548287 193.1118256 0.823663248 -0.279873479 0.59956323 1 1.805429522 1.551122713 7049 transforming growth factor beta receptor 3 "GO:0001525,GO:0001570,GO:0001666,GO:0001837,GO:0001889,GO:0003007,GO:0003150,GO:0003151,GO:0003223,GO:0005024,GO:0005114,GO:0005160,GO:0005515,GO:0005539,GO:0005615,GO:0005737,GO:0005887,GO:0006955,GO:0007179,GO:0007181,GO:0008201,GO:0009897,GO:0009986,GO:0015026,GO:0016477,GO:0017015,GO:0017134,GO:0030165,GO:0030509,GO:0030511,GO:0030512,GO:0031012,GO:0031100,GO:0032354,GO:0034673,GO:0034695,GO:0034699,GO:0035556,GO:0043235,GO:0043393,GO:0046328,GO:0046332,GO:0048185,GO:0050431,GO:0050680,GO:0051271,GO:0055010,GO:0060038,GO:0060045,GO:0060216,GO:0060317,GO:0060318,GO:0060347,GO:0060389,GO:0060412,GO:0060939,GO:0060979,GO:0061384,GO:0062009,GO:0070062,GO:0070123,GO:0070372" "angiogenesis|vasculogenesis|response to hypoxia|epithelial to mesenchymal transition|liver development|heart morphogenesis|muscular septum morphogenesis|outflow tract morphogenesis|ventricular compact myocardium morphogenesis|transforming growth factor beta-activated receptor activity|type II transforming growth factor beta receptor binding|transforming growth factor beta receptor binding|protein binding|glycosaminoglycan binding|extracellular space|cytoplasm|integral component of plasma membrane|immune response|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor complex assembly|heparin binding|external side of plasma membrane|cell surface|coreceptor activity|cell migration|regulation of transforming growth factor beta receptor signaling pathway|fibroblast growth factor binding|PDZ domain binding|BMP signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|animal organ regeneration|response to follicle-stimulating hormone|inhibin-betaglycan-ActRII complex|response to prostaglandin E|response to luteinizing hormone|intracellular signal transduction|receptor complex|regulation of protein binding|regulation of JNK cascade|SMAD binding|activin binding|transforming growth factor beta binding|negative regulation of epithelial cell proliferation|negative regulation of cellular component movement|ventricular cardiac muscle tissue morphogenesis|cardiac muscle cell proliferation|positive regulation of cardiac muscle cell proliferation|definitive hemopoiesis|cardiac epithelial to mesenchymal transition|definitive erythrocyte differentiation|heart trabecula formation|pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|epicardium-derived cardiac fibroblast cell development|vasculogenesis involved in coronary vascular morphogenesis|heart trabecula morphogenesis|secondary palate development|extracellular exosome|transforming growth factor beta receptor activity, type III|regulation of ERK1 and ERK2 cascade" TGFBR3L 113.3566262 104.5404647 122.1727877 1.168665052 0.224861502 0.738748025 1 1.783896814 2.174581637 100507588 transforming growth factor beta receptor 3 like "GO:0001525,GO:0001570,GO:0001837,GO:0005024,GO:0005114,GO:0005539,GO:0005615,GO:0007179,GO:0009986,GO:0016021,GO:0016477,GO:0017015,GO:0050431" angiogenesis|vasculogenesis|epithelial to mesenchymal transition|transforming growth factor beta-activated receptor activity|type II transforming growth factor beta receptor binding|glycosaminoglycan binding|extracellular space|transforming growth factor beta receptor signaling pathway|cell surface|integral component of membrane|cell migration|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta binding TGFBRAP1 666.4809051 804.8600829 528.1017273 0.656141034 -0.607922146 0.111622227 1 6.072296116 4.155909392 9392 transforming growth factor beta receptor associated protein 1 "GO:0005160,GO:0005515,GO:0005737,GO:0005769,GO:0006355,GO:0006886,GO:0006914,GO:0007165,GO:0007179,GO:0008333,GO:0016020,GO:0033263,GO:0034058,GO:0043231,GO:0046332" "transforming growth factor beta receptor binding|protein binding|cytoplasm|early endosome|regulation of transcription, DNA-templated|intracellular protein transport|autophagy|signal transduction|transforming growth factor beta receptor signaling pathway|endosome to lysosome transport|membrane|CORVET complex|endosomal vesicle fusion|intracellular membrane-bounded organelle|SMAD binding" TGIF1 1724.22659 1482.85067 1965.602511 1.325556613 0.406598287 0.213024441 1 15.74447699 21.76919897 7050 TGFB induced factor homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0042493,GO:0070410,GO:0071363,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|response to drug|co-SMAD binding|cellular response to growth factor stimulus|sequence-specific double-stranded DNA binding" hsa04350 TGF-beta signaling pathway TGIF2 512.14005 592.7342855 431.5458144 0.728059478 -0.457871781 0.259810194 1 8.564878893 6.504351699 60436 TGFB induced factor homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005813,GO:0006355,GO:0006357,GO:0010470,GO:0038092,GO:0045666,GO:0060041,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|centrosome|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|regulation of gastrulation|nodal signaling pathway|positive regulation of neuron differentiation|retina development in camera-type eye|sequence-specific double-stranded DNA binding" hsa04350 TGF-beta signaling pathway TGM1 13.47921893 12.17947162 14.77896625 1.213432463 0.279093814 0.880229941 1 0.224798568 0.284528045 7051 transglutaminase 1 "GO:0001533,GO:0003810,GO:0005515,GO:0005829,GO:0005886,GO:0006464,GO:0010838,GO:0016020,GO:0018149,GO:0018215,GO:0030216,GO:0031224,GO:0042802,GO:0043163,GO:0045787,GO:0046872,GO:0070062,GO:0070268" cornified envelope|protein-glutamine gamma-glutamyltransferase activity|protein binding|cytosol|plasma membrane|cellular protein modification process|positive regulation of keratinocyte proliferation|membrane|peptide cross-linking|protein phosphopantetheinylation|keratinocyte differentiation|intrinsic component of membrane|identical protein binding|cell envelope organization|positive regulation of cell cycle|metal ion binding|extracellular exosome|cornification TGM2 25779.95652 38328.79719 13231.11585 0.345200393 -1.534493988 7.33E-05 0.012574682 370.037812 133.2395985 7052 transglutaminase 2 "GO:0001974,GO:0003810,GO:0005515,GO:0005525,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0005925,GO:0018149,GO:0018153,GO:0018215,GO:0019904,GO:0031226,GO:0032471,GO:0042802,GO:0043065,GO:0043123,GO:0043277,GO:0045785,GO:0046872,GO:0048661,GO:0050729,GO:0051482,GO:0051561,GO:0060445,GO:0060662,GO:0062023,GO:0070062" blood vessel remodeling|protein-glutamine gamma-glutamyltransferase activity|protein binding|GTP binding|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|focal adhesion|peptide cross-linking|isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|protein phosphopantetheinylation|protein domain specific binding|intrinsic component of plasma membrane|negative regulation of endoplasmic reticulum calcium ion concentration|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|apoptotic cell clearance|positive regulation of cell adhesion|metal ion binding|positive regulation of smooth muscle cell proliferation|positive regulation of inflammatory response|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of mitochondrial calcium ion concentration|branching involved in salivary gland morphogenesis|salivary gland cavitation|collagen-containing extracellular matrix|extracellular exosome hsa05016 Huntington disease TGM4 29.85212641 53.79266632 5.911586499 0.10989577 -3.185792235 0.003719144 0.21983998 0.868475862 0.099553071 7047 transglutaminase 4 "GO:0003810,GO:0005737,GO:0005794,GO:0018149,GO:0018215,GO:0046872,GO:0062023,GO:0070062" protein-glutamine gamma-glutamyltransferase activity|cytoplasm|Golgi apparatus|peptide cross-linking|protein phosphopantetheinylation|metal ion binding|collagen-containing extracellular matrix|extracellular exosome TGOLN2 7320.504988 6364.788878 8276.221099 1.300313531 0.378859527 0.249182569 1 52.77572086 71.58106993 10618 trans-golgi network protein 2 "GO:0005515,GO:0005654,GO:0005768,GO:0005788,GO:0005794,GO:0005802,GO:0005886,GO:0016021,GO:0030133,GO:0030140,GO:0030665,GO:0043687,GO:0044267,GO:0061024" protein binding|nucleoplasm|endosome|endoplasmic reticulum lumen|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of membrane|transport vesicle|trans-Golgi network transport vesicle|clathrin-coated vesicle membrane|post-translational protein modification|cellular protein metabolic process|membrane organization TGS1 1009.301458 1070.778547 947.8243687 0.885173103 -0.175968481 0.618152348 1 15.58366549 14.38844152 96764 trimethylguanosine synthase 1 "GO:0000387,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0008173,GO:0009452,GO:0015030,GO:0019216,GO:0022613,GO:0030532,GO:0036261,GO:0071164" spliceosomal snRNP assembly|protein binding|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|RNA methyltransferase activity|7-methylguanosine RNA capping|Cajal body|regulation of lipid metabolic process|ribonucleoprotein complex biogenesis|small nuclear ribonucleoprotein complex|7-methylguanosine cap hypermethylation|RNA trimethylguanosine synthase activity hsa03013 RNA transport TH 2.478006817 1.014955968 3.941057666 3.882983882 1.957165719 0.555182938 1 0.026772885 0.108436799 7054 tyrosine hydroxylase "GO:0001666,GO:0001963,GO:0001975,GO:0003007,GO:0004511,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005790,GO:0005829,GO:0006585,GO:0006631,GO:0006665,GO:0007507,GO:0007601,GO:0007605,GO:0007612,GO:0007613,GO:0007617,GO:0007626,GO:0008016,GO:0008021,GO:0008198,GO:0008199,GO:0009414,GO:0009416,GO:0009635,GO:0009651,GO:0009653,GO:0009887,GO:0009898,GO:0010043,GO:0010259,GO:0014823,GO:0015842,GO:0016137,GO:0016597,GO:0018963,GO:0019825,GO:0019899,GO:0019904,GO:0021987,GO:0030424,GO:0030425,GO:0031410,GO:0031667,GO:0032355,GO:0032496,GO:0033076,GO:0033162,GO:0034617,GO:0035176,GO:0035240,GO:0035690,GO:0035900,GO:0035902,GO:0042136,GO:0042214,GO:0042416,GO:0042418,GO:0042421,GO:0042423,GO:0042462,GO:0042745,GO:0042755,GO:0043005,GO:0043195,GO:0043204,GO:0043434,GO:0043473,GO:0045471,GO:0045472,GO:0046684,GO:0048471,GO:0048596,GO:0051412,GO:0051602,GO:0052314,GO:0055114,GO:0071287,GO:0071312,GO:0071316,GO:0071333,GO:0071363,GO:1990384" "response to hypoxia|synaptic transmission, dopaminergic|response to amphetamine|heart morphogenesis|tyrosine 3-monooxygenase activity|protein binding|nucleus|cytoplasm|mitochondrion|smooth endoplasmic reticulum|cytosol|dopamine biosynthetic process from tyrosine|fatty acid metabolic process|sphingolipid metabolic process|heart development|visual perception|sensory perception of sound|learning|memory|mating behavior|locomotory behavior|regulation of heart contraction|synaptic vesicle|ferrous iron binding|ferric iron binding|response to water deprivation|response to light stimulus|response to herbicide|response to salt stress|anatomical structure morphogenesis|animal organ morphogenesis|cytoplasmic side of plasma membrane|response to zinc ion|multicellular organism aging|response to activity|aminergic neurotransmitter loading into synaptic vesicle|glycoside metabolic process|amino acid binding|phthalate metabolic process|oxygen binding|enzyme binding|protein domain specific binding|cerebral cortex development|axon|dendrite|cytoplasmic vesicle|response to nutrient levels|response to estradiol|response to lipopolysaccharide|isoquinoline alkaloid metabolic process|melanosome membrane|tetrahydrobiopterin binding|social behavior|dopamine binding|cellular response to drug|response to isolation stress|response to immobilization stress|neurotransmitter biosynthetic process|terpene metabolic process|dopamine biosynthetic process|epinephrine biosynthetic process|norepinephrine biosynthetic process|catecholamine biosynthetic process|eye photoreceptor cell development|circadian sleep/wake cycle|eating behavior|neuron projection|terminal bouton|perikaryon|response to peptide hormone|pigmentation|response to ethanol|response to ether|response to pyrethroid|perinuclear region of cytoplasm|embryonic camera-type eye morphogenesis|response to corticosterone|response to electrical stimulus|phytoalexin metabolic process|oxidation-reduction process|cellular response to manganese ion|cellular response to alkaloid|cellular response to nicotine|cellular response to glucose stimulus|cellular response to growth factor stimulus|hyaloid vascular plexus regression" "hsa00350,hsa00790,hsa04728,hsa04917,hsa05012,hsa05030,hsa05031,hsa05034" Tyrosine metabolism|Folate biosynthesis|Dopaminergic synapse|Prolactin signaling pathway|Parkinson disease|Cocaine addiction|Amphetamine addiction|Alcoholism THADA 507.6145639 620.1380967 395.091031 0.637101693 -0.650404425 0.110454545 1 4.490036723 2.983833473 63892 THADA armadillo repeat containing "GO:0005515,GO:0005829,GO:0030488,GO:0032471,GO:0055088,GO:0098554,GO:1901895,GO:1990845" protein binding|cytosol|tRNA methylation|negative regulation of endoplasmic reticulum calcium ion concentration|lipid homeostasis|cytoplasmic side of endoplasmic reticulum membrane|negative regulation of ATPase-coupled calcium transmembrane transporter activity|adaptive thermogenesis THAP1 213.2016203 228.3650929 198.0381477 0.867199734 -0.205563781 0.702461681 1 5.352099181 4.841269044 55145 THAP domain containing 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001650,GO:0001935,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0006357,GO:0007049,GO:0007346,GO:0008270,GO:0016605,GO:0042802,GO:0042803,GO:0043231,GO:0043565" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|fibrillar center|endothelial cell proliferation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle|regulation of mitotic cell cycle|zinc ion binding|PML body|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|sequence-specific DNA binding" THAP THAP10 140.2111436 121.7947162 158.6275711 1.30241751 0.381192001 0.533234447 1 3.013420962 4.093793775 56906 THAP domain containing 10 "GO:0003677,GO:0005515,GO:0046872" DNA binding|protein binding|metal ion binding THAP11 781.1130303 828.2040702 734.0219903 0.886281554 -0.174163008 0.638709567 1 22.35906952 20.67004236 57215 THAP domain containing 11 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0008270" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|zinc ion binding" THAP THAP12 1034.719894 1124.571213 944.8685755 0.840203417 -0.251189442 0.473923588 1 16.31964604 14.30247206 5612 THAP domain containing 12 "GO:0003677,GO:0005515,GO:0005634,GO:0007165,GO:0008285,GO:0046872,GO:0046983" DNA binding|protein binding|nucleus|signal transduction|negative regulation of cell population proliferation|metal ion binding|protein dimerization activity THAP2 77.09755947 84.24134538 69.95377357 0.830397155 -0.268126593 0.728125717 1 0.962664025 0.833828096 83591 THAP domain containing 2 "GO:0003677,GO:0005634,GO:0005730,GO:0046872" DNA binding|nucleus|nucleolus|metal ion binding THAP3 263.0883637 270.9932436 255.1834839 0.941659949 -0.086721925 0.867465346 1 3.679584927 3.614172359 90326 THAP domain containing 3 "GO:0003677,GO:0005515,GO:0045944,GO:0046872" DNA binding|protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding THAP4 974.243661 964.20817 984.2791521 1.020816026 0.029722883 0.936081867 1 20.33045058 21.64763282 51078 THAP domain containing 4 "GO:0003677,GO:0005515,GO:0005575,GO:0006570,GO:0020037,GO:0042126,GO:0042802,GO:0046872,GO:0062213,GO:0070026" DNA binding|protein binding|cellular_component|tyrosine metabolic process|heme binding|nitrate metabolic process|identical protein binding|metal ion binding|peroxynitrite isomerase activity|nitric oxide binding THAP5 446.6335743 425.2665507 468.0005979 1.100487675 0.138142988 0.746322457 1 5.666469494 6.504496254 168451 THAP domain containing 5 "GO:0000122,GO:0000785,GO:0002020,GO:0003677,GO:0005634,GO:0005654,GO:0007049,GO:0045786,GO:0046872" negative regulation of transcription by RNA polymerase II|chromatin|protease binding|DNA binding|nucleus|nucleoplasm|cell cycle|negative regulation of cell cycle|metal ion binding THAP6 215.7268861 198.9313698 232.5224023 1.168857393 0.225098924 0.673658908 1 1.714631057 2.090490237 152815 THAP domain containing 6 "GO:0003677,GO:0005515,GO:0015630,GO:0046872" DNA binding|protein binding|microtubule cytoskeleton|metal ion binding THAP7 266.7743216 287.232539 246.3161041 0.857549444 -0.221708239 0.655583637 1 8.379789636 7.495631294 80764 THAP domain containing 7 "GO:0000122,GO:0001226,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006355,GO:0016607,GO:0031493,GO:0031965,GO:0035064,GO:0035067,GO:0042802,GO:0042826,GO:0043231,GO:0045892,GO:0046872,GO:0047485,GO:0070577,GO:0070742,GO:0106153,GO:0140296" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|regulation of transcription, DNA-templated|nuclear speck|nucleosomal histone binding|nuclear membrane|methylated histone binding|negative regulation of histone acetylation|identical protein binding|histone deacetylase binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|metal ion binding|protein N-terminus binding|lysine-acetylated histone binding|C2H2 zinc finger domain binding|phosphorylated histone binding|general transcription initiation factor binding" THAP8 48.61668765 56.83753423 40.39584108 0.710724728 -0.492637199 0.574231599 1 1.632796709 1.210457296 199745 THAP domain containing 8 "GO:0003677,GO:0005515,GO:0046872" DNA binding|protein binding|metal ion binding THAP9 84.51673415 86.27125731 82.76221099 0.95932543 -0.059907795 0.950964402 1 1.001681531 1.002331901 79725 THAP domain containing 9 "GO:0003677,GO:0004803,GO:0006310,GO:0006313,GO:0015074,GO:0016740,GO:0043565,GO:0046872" "DNA binding|transposase activity|DNA recombination|transposition, DNA-mediated|DNA integration|transferase activity|sequence-specific DNA binding|metal ion binding" THBD 188.6172688 197.9164138 179.3181238 0.906029572 -0.142369955 0.803239133 1 2.481130731 2.344811583 7056 thrombomodulin "GO:0004888,GO:0005509,GO:0005515,GO:0005615,GO:0005774,GO:0005886,GO:0005887,GO:0007565,GO:0007596,GO:0009897,GO:0009986,GO:0010165,GO:0010544,GO:0016327,GO:0030195,GO:0032496,GO:0038023,GO:0050900,GO:0051591,GO:0051918" transmembrane signaling receptor activity|calcium ion binding|protein binding|extracellular space|vacuolar membrane|plasma membrane|integral component of plasma membrane|female pregnancy|blood coagulation|external side of plasma membrane|cell surface|response to X-ray|negative regulation of platelet activation|apicolateral plasma membrane|negative regulation of blood coagulation|response to lipopolysaccharide|signaling receptor activity|leukocyte migration|response to cAMP|negative regulation of fibrinolysis "hsa04610,hsa04933,hsa05418" Complement and coagulation cascades|AGE-RAGE signaling pathway in diabetic complications|Fluid shear stress and atherosclerosis THBS1 1145.425807 1148.930156 1141.921459 0.993899805 -0.008827673 0.982393737 1 10.04995842 10.41892232 7057 thrombospondin 1 "GO:0000187,GO:0001666,GO:0001786,GO:0001937,GO:0001953,GO:0001968,GO:0002040,GO:0002544,GO:0002576,GO:0002581,GO:0002605,GO:0005178,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005577,GO:0005615,GO:0005783,GO:0005788,GO:0006954,GO:0006955,GO:0006986,GO:0007050,GO:0007155,GO:0008201,GO:0008284,GO:0009612,GO:0009749,GO:0009897,GO:0009986,GO:0010595,GO:0010596,GO:0010748,GO:0010751,GO:0010754,GO:0010757,GO:0010759,GO:0010763,GO:0016477,GO:0016525,GO:0016529,GO:0017134,GO:0018149,GO:0030141,GO:0030169,GO:0030194,GO:0030198,GO:0030335,GO:0030511,GO:0031012,GO:0031091,GO:0031093,GO:0032026,GO:0032570,GO:0032695,GO:0032760,GO:0032914,GO:0033574,GO:0034605,GO:0034976,GO:0040037,GO:0042327,GO:0042493,GO:0042802,GO:0043032,GO:0043066,GO:0043154,GO:0043236,GO:0043394,GO:0043536,GO:0043537,GO:0043652,GO:0045652,GO:0045727,GO:0045766,GO:0048266,GO:0048661,GO:0050431,GO:0050921,GO:0051592,GO:0051895,GO:0051897,GO:0051918,GO:0062023,GO:0070051,GO:0070052,GO:0070062,GO:0071356,GO:0071363,GO:0090051,GO:1902043,GO:1903588,GO:1903671,GO:2000353,GO:2000379,GO:2001027,GO:2001237" activation of MAPK activity|response to hypoxia|phosphatidylserine binding|negative regulation of endothelial cell proliferation|negative regulation of cell-matrix adhesion|fibronectin binding|sprouting angiogenesis|chronic inflammatory response|platelet degranulation|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of dendritic cell antigen processing and presentation|integrin binding|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|fibrinogen complex|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|inflammatory response|immune response|response to unfolded protein|cell cycle arrest|cell adhesion|heparin binding|positive regulation of cell population proliferation|response to mechanical stimulus|response to glucose|external side of plasma membrane|cell surface|positive regulation of endothelial cell migration|negative regulation of endothelial cell migration|negative regulation of long-chain fatty acid import across plasma membrane|negative regulation of nitric oxide mediated signal transduction|negative regulation of cGMP-mediated signaling|negative regulation of plasminogen activation|positive regulation of macrophage chemotaxis|positive regulation of fibroblast migration|cell migration|negative regulation of angiogenesis|sarcoplasmic reticulum|fibroblast growth factor binding|peptide cross-linking|secretory granule|low-density lipoprotein particle binding|positive regulation of blood coagulation|extracellular matrix organization|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|platelet alpha granule|platelet alpha granule lumen|response to magnesium ion|response to progesterone|negative regulation of interleukin-12 production|positive regulation of tumor necrosis factor production|positive regulation of transforming growth factor beta1 production|response to testosterone|cellular response to heat|response to endoplasmic reticulum stress|negative regulation of fibroblast growth factor receptor signaling pathway|positive regulation of phosphorylation|response to drug|identical protein binding|positive regulation of macrophage activation|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|laminin binding|proteoglycan binding|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|engulfment of apoptotic cell|regulation of megakaryocyte differentiation|positive regulation of translation|positive regulation of angiogenesis|behavioral response to pain|positive regulation of smooth muscle cell proliferation|transforming growth factor beta binding|positive regulation of chemotaxis|response to calcium ion|negative regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of fibrinolysis|collagen-containing extracellular matrix|fibrinogen binding|collagen V binding|extracellular exosome|cellular response to tumor necrosis factor|cellular response to growth factor stimulus|negative regulation of cell migration involved in sprouting angiogenesis|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|negative regulation of sprouting angiogenesis|positive regulation of endothelial cell apoptotic process|positive regulation of reactive oxygen species metabolic process|negative regulation of endothelial cell chemotaxis|negative regulation of extrinsic apoptotic signaling pathway "hsa04015,hsa04115,hsa04145,hsa04151,hsa04350,hsa04510,hsa04512,hsa05144,hsa05165,hsa05205,hsa05206,hsa05219" Rap1 signaling pathway|p53 signaling pathway|Phagosome|PI3K-Akt signaling pathway|TGF-beta signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection|Proteoglycans in cancer|MicroRNAs in cancer|Bladder cancer THBS2 892.0253006 1068.748635 715.3019664 0.669289245 -0.579298264 0.107630903 1 8.257566442 5.764768246 7058 thrombospondin 2 "GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0007155,GO:0008201,GO:0016525,GO:0031091,GO:0062023" extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|cell adhesion|heparin binding|negative regulation of angiogenesis|platelet alpha granule|collagen-containing extracellular matrix "hsa04145,hsa04151,hsa04510,hsa04512,hsa05144,hsa05165" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection THBS3 494.7252166 513.56772 475.8827132 0.926621154 -0.109948477 0.79223661 1 5.188588322 5.014958622 7059 thrombospondin 3 "GO:0003417,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0007160,GO:0008201,GO:0043931,GO:0048471,GO:0060346,GO:0062023" growth plate cartilage development|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|cell-matrix adhesion|heparin binding|ossification involved in bone maturation|perinuclear region of cytoplasm|bone trabecula formation|collagen-containing extracellular matrix "hsa04145,hsa04151,hsa04510,hsa04512,hsa05144,hsa05165" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection THBS4 11.47899855 10.14955968 12.80843742 1.261969762 0.335677342 0.860335721 1 0.132347938 0.174213601 7060 thrombospondin 4 "GO:0001938,GO:0005178,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005783,GO:0006986,GO:0007165,GO:0008083,GO:0008201,GO:0016525,GO:0016529,GO:0034103,GO:0034976,GO:0048266,GO:0048771,GO:0050731,GO:0051451,GO:0051781,GO:0062023,GO:0070062,GO:0071603,GO:0090023" positive regulation of endothelial cell proliferation|integrin binding|calcium ion binding|protein binding|extracellular region|basement membrane|extracellular space|endoplasmic reticulum|response to unfolded protein|signal transduction|growth factor activity|heparin binding|negative regulation of angiogenesis|sarcoplasmic reticulum|regulation of tissue remodeling|response to endoplasmic reticulum stress|behavioral response to pain|tissue remodeling|positive regulation of peptidyl-tyrosine phosphorylation|myoblast migration|positive regulation of cell division|collagen-containing extracellular matrix|extracellular exosome|endothelial cell-cell adhesion|positive regulation of neutrophil chemotaxis "hsa04145,hsa04151,hsa04510,hsa04512,hsa05144,hsa05165" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection THEM4 504.6439248 619.1231407 390.164709 0.630189187 -0.666143094 0.102644164 1 6.492008891 4.267425844 117145 thioesterase superfamily member 4 "GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0005829,GO:0005886,GO:0006631,GO:0006637,GO:0016290,GO:0032587,GO:0043491,GO:0051898,GO:0102991,GO:1902108" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|cytosol|plasma membrane|fatty acid metabolic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|ruffle membrane|protein kinase B signaling|negative regulation of protein kinase B signaling|myristoyl-CoA hydrolase activity|regulation of mitochondrial membrane permeability involved in apoptotic process "hsa00062,hsa04151" Fatty acid elongation|PI3K-Akt signaling pathway THEM6 310.3377561 436.4310664 184.2444459 0.42216162 -1.244132671 0.008499466 0.38529018 10.6267759 4.679464958 51337 thioesterase superfamily member 6 GO:0005576 extracellular region THEMIS2 244.72736 261.8586398 227.5960802 0.869156276 -0.202312495 0.693414863 1 5.667613815 5.138236033 9473 thymocyte selection associated family member 2 "GO:0005515,GO:0005634,GO:0005737,GO:0006954,GO:0007155,GO:0050852" protein binding|nucleus|cytoplasm|inflammatory response|cell adhesion|T cell receptor signaling pathway THG1L 488.2225207 439.4759343 536.969107 1.221839616 0.289054924 0.483230015 1 6.800460035 8.666992582 54974 tRNA-histidine guanylyltransferase 1 like "GO:0000049,GO:0000287,GO:0005085,GO:0005515,GO:0005524,GO:0005525,GO:0005739,GO:0005741,GO:0005829,GO:0006400,GO:0006979,GO:0008033,GO:0008053,GO:0008193,GO:0016779,GO:0042802,GO:0050790,GO:0051289,GO:0099116,GO:1990046,GO:1990234" tRNA binding|magnesium ion binding|guanyl-nucleotide exchange factor activity|protein binding|ATP binding|GTP binding|mitochondrion|mitochondrial outer membrane|cytosol|tRNA modification|response to oxidative stress|tRNA processing|mitochondrial fusion|tRNA guanylyltransferase activity|nucleotidyltransferase activity|identical protein binding|regulation of catalytic activity|protein homotetramerization|tRNA 5'-end processing|stress-induced mitochondrial fusion|transferase complex THNSL1 105.7241675 155.2882632 56.16007174 0.36165046 -1.46733211 0.029553172 0.763169617 1.949628831 0.735456329 79896 threonine synthase like 1 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process THOC1 505.7439961 492.2536447 519.2343475 1.05481057 0.076983933 0.854460859 1 6.435444124 7.080581511 9984 THO complex 1 "GO:0000018,GO:0000346,GO:0000347,GO:0000445,GO:0000781,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006396,GO:0006405,GO:0006406,GO:0006915,GO:0007165,GO:0008380,GO:0016363,GO:0016607,GO:0031124,GO:0031297,GO:0032784,GO:0032786,GO:0046784,GO:0048297,GO:2000002" "regulation of DNA recombination|transcription export complex|THO complex|THO complex part of transcription export complex|chromosome, telomeric region|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|RNA processing|RNA export from nucleus|mRNA export from nucleus|apoptotic process|signal transduction|RNA splicing|nuclear matrix|nuclear speck|mRNA 3'-end processing|replication fork processing|regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|viral mRNA export from host cell nucleus|negative regulation of isotype switching to IgA isotypes|negative regulation of DNA damage checkpoint" "hsa03013,hsa03040" RNA transport|Spliceosome THOC2 2232.011139 2215.648879 2248.373399 1.014769723 0.02115238 0.948795265 1 14.39758781 15.23958591 57187 THO complex 2 "GO:0000346,GO:0000347,GO:0000445,GO:0000781,GO:0003729,GO:0005515,GO:0005654,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0016973,GO:0031124,GO:0046784,GO:0048666,GO:0048699" "transcription export complex|THO complex|THO complex part of transcription export complex|chromosome, telomeric region|mRNA binding|protein binding|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|viral mRNA export from host cell nucleus|neuron development|generation of neurons" "hsa03013,hsa03040" RNA transport|Spliceosome THOC3 828.560861 939.8492267 717.2724952 0.763178258 -0.389908024 0.285337444 1 17.61008056 14.01855538 84321 THO complex 3 "GO:0000346,GO:0000445,GO:0000781,GO:0003723,GO:0005654,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0046784" "transcription export complex|THO complex part of transcription export complex|chromosome, telomeric region|RNA binding|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|viral mRNA export from host cell nucleus" "hsa03013,hsa03040" RNA transport|Spliceosome THOC5 1385.724921 1343.801702 1427.64814 1.062394948 0.087320191 0.795948206 1 13.07314936 14.48712307 8563 THO complex 5 "GO:0000346,GO:0000347,GO:0000445,GO:0000781,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006405,GO:0006406,GO:0008380,GO:0030224,GO:0031124,GO:0032786,GO:0046784,GO:0060215,GO:2000002" "transcription export complex|THO complex|THO complex part of transcription export complex|chromosome, telomeric region|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|RNA export from nucleus|mRNA export from nucleus|RNA splicing|monocyte differentiation|mRNA 3'-end processing|positive regulation of DNA-templated transcription, elongation|viral mRNA export from host cell nucleus|primitive hemopoiesis|negative regulation of DNA damage checkpoint" hsa03013 RNA transport THOC6 608.9334952 608.973581 608.8934094 0.99986835 -0.000189944 1 1 23.63399506 24.64880626 79228 THO complex 6 "GO:0000346,GO:0000347,GO:0000445,GO:0000781,GO:0003723,GO:0005634,GO:0005654,GO:0006405,GO:0006406,GO:0006915,GO:0007417,GO:0008380,GO:0016604,GO:0016607,GO:0031124,GO:0043066,GO:0046784" "transcription export complex|THO complex|THO complex part of transcription export complex|chromosome, telomeric region|RNA binding|nucleus|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|apoptotic process|central nervous system development|RNA splicing|nuclear body|nuclear speck|mRNA 3'-end processing|negative regulation of apoptotic process|viral mRNA export from host cell nucleus" hsa03013 RNA transport THOC7 819.9067653 887.0715164 752.7420142 0.848569704 -0.236894923 0.517901576 1 35.62810698 31.53524431 80145 THO complex 7 "GO:0000346,GO:0000347,GO:0000445,GO:0000781,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0046784" "transcription export complex|THO complex|THO complex part of transcription export complex|chromosome, telomeric region|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|viral mRNA export from host cell nucleus" hsa03013 RNA transport THOP1 1535.896588 1607.690254 1464.102923 0.910687192 -0.134972501 0.6840743 1 18.96223562 18.01252917 7064 thimet oligopeptidase 1 "GO:0000209,GO:0004222,GO:0005515,GO:0005758,GO:0005829,GO:0006508,GO:0006518,GO:0042277,GO:0046872" protein polyubiquitination|metalloendopeptidase activity|protein binding|mitochondrial intermembrane space|cytosol|proteolysis|peptide metabolic process|peptide binding|metal ion binding "hsa04614,hsa05143" Renin-angiotensin system|African trypanosomiasis THRA 1163.118751 1112.391741 1213.845761 1.0912035 0.125920176 0.715602773 1 8.927066616 10.16085972 7067 thyroid hormone receptor alpha "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001502,GO:0001503,GO:0002154,GO:0002155,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0006367,GO:0007611,GO:0008016,GO:0008050,GO:0008134,GO:0008270,GO:0009409,GO:0009755,GO:0017025,GO:0017055,GO:0019904,GO:0030154,GO:0030218,GO:0030878,GO:0031490,GO:0033032,GO:0044877,GO:0045892,GO:0045925,GO:0045944,GO:0050994,GO:0060509,GO:0070324,GO:0120162,GO:2000143" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cartilage condensation|ossification|thyroid hormone mediated signaling pathway|regulation of thyroid hormone mediated signaling pathway|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|learning or memory|regulation of heart contraction|female courtship behavior|transcription factor binding|zinc ion binding|response to cold|hormone-mediated signaling pathway|TBP-class protein binding|negative regulation of RNA polymerase II transcription preinitiation complex assembly|protein domain specific binding|cell differentiation|erythrocyte differentiation|thyroid gland development|chromatin DNA binding|regulation of myeloid cell apoptotic process|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of female receptivity|positive regulation of transcription by RNA polymerase II|regulation of lipid catabolic process|type I pneumocyte differentiation|thyroid hormone binding|positive regulation of cold-induced thermogenesis|negative regulation of DNA-templated transcription, initiation" "hsa04080,hsa04919" Neuroactive ligand-receptor interaction|Thyroid hormone signaling pathway THRAP3 3318.802827 3498.553223 3139.052431 0.897243012 -0.156429313 0.623157181 1 35.92647579 33.62332291 9967 thyroid hormone receptor associated protein 3 "GO:0000381,GO:0000956,GO:0000978,GO:0003677,GO:0003712,GO:0003713,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0016592,GO:0016607,GO:0030374,GO:0035145,GO:0042753,GO:0042809,GO:0045893,GO:0045944,GO:0046966,GO:0048026,GO:0048255,GO:0048511,GO:0051219,GO:0070062" "regulation of alternative mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA binding|transcription coregulator activity|transcription coactivator activity|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|mediator complex|nuclear speck|nuclear receptor coactivator activity|exon-exon junction complex|positive regulation of circadian rhythm|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|positive regulation of mRNA splicing, via spliceosome|mRNA stabilization|rhythmic process|phosphoprotein binding|extracellular exosome" THRB 328.4006066 256.78386 400.0173531 1.557797882 0.639508061 0.164635835 1 1.201403846 1.952162907 7068 thyroid hormone receptor beta "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001225,GO:0002154,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006367,GO:0007605,GO:0007621,GO:0008016,GO:0008050,GO:0008270,GO:0009755,GO:0016604,GO:0019899,GO:0030154,GO:0031490,GO:0042480,GO:0045944,GO:0046549,GO:0060509,GO:0070324,GO:0097067,GO:0097474,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription coactivator binding|thyroid hormone mediated signaling pathway|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|sensory perception of sound|negative regulation of female receptivity|regulation of heart contraction|female courtship behavior|zinc ion binding|hormone-mediated signaling pathway|nuclear body|enzyme binding|cell differentiation|chromatin DNA binding|negative regulation of eye photoreceptor cell development|positive regulation of transcription by RNA polymerase II|retinal cone cell development|type I pneumocyte differentiation|thyroid hormone binding|cellular response to thyroid hormone stimulus|retinal cone cell apoptotic process|sequence-specific double-stranded DNA binding" "hsa04080,hsa04919" Neuroactive ligand-receptor interaction|Thyroid hormone signaling pathway THSD1 72.71112853 53.79266632 91.62959074 1.703384439 0.768404075 0.309400527 1 0.900333371 1.599675719 55901 thrombospondin type 1 domain containing 1 "GO:0005515,GO:0005576,GO:0005768,GO:0005829,GO:0005925,GO:0010008,GO:0016021,GO:0048041,GO:0050840,GO:0071944" protein binding|extracellular region|endosome|cytosol|focal adhesion|endosome membrane|integral component of membrane|focal adhesion assembly|extracellular matrix binding|cell periphery THSD4 7843.010358 7262.009954 8424.010761 1.160010908 0.214138372 0.516615525 1 25.54310614 30.90663412 79875 thrombospondin type 1 domain containing 4 "GO:0001527,GO:0004222,GO:0005201,GO:0006508,GO:0030198,GO:0031012,GO:0048251,GO:0062023,GO:0070062" microfibril|metalloendopeptidase activity|extracellular matrix structural constituent|proteolysis|extracellular matrix organization|extracellular matrix|elastic fiber assembly|collagen-containing extracellular matrix|extracellular exosome hsa04350 TGF-beta signaling pathway THSD7A 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.015087743 0.011457954 221981 thrombospondin type 1 domain containing 7A "GO:0001525,GO:0005515,GO:0005576,GO:0005886,GO:0016021,GO:0030154,GO:0031532,GO:0042995" angiogenesis|protein binding|extracellular region|plasma membrane|integral component of membrane|cell differentiation|actin cytoskeleton reorganization|cell projection THTPA 212.8574459 238.5146526 187.2002391 0.784858444 -0.349495619 0.510835495 1 4.165491629 3.410150381 79178 thiamine triphosphatase "GO:0000287,GO:0005515,GO:0005829,GO:0006091,GO:0006772,GO:0016311,GO:0016787,GO:0042357,GO:0042723,GO:0050333" magnesium ion binding|protein binding|cytosol|generation of precursor metabolites and energy|thiamine metabolic process|dephosphorylation|hydrolase activity|thiamine diphosphate metabolic process|thiamine-containing compound metabolic process|thiamin-triphosphatase activity hsa00730 Thiamine metabolism THUMPD1 739.363502 769.336624 709.3903799 0.922080605 -0.117035223 0.756430044 1 7.37539011 7.093650931 55623 THUMP domain containing 1 "GO:0000154,GO:0003723,GO:0005515,GO:0005654,GO:0006400" rRNA modification|RNA binding|protein binding|nucleoplasm|tRNA modification THUMPD2 94.60691073 102.5105528 86.70326866 0.845798469 -0.241614145 0.736699541 1 1.740461905 1.535491253 80745 THUMP domain containing 2 "GO:0003723,GO:0005515,GO:0016423,GO:0030488" RNA binding|protein binding|tRNA (guanine) methyltransferase activity|tRNA methylation THUMPD3 1070.845349 1135.735729 1005.954969 0.885729791 -0.175061451 0.616383825 1 12.8653563 11.88608961 25917 THUMP domain containing 3 "GO:0003723,GO:0005515,GO:0005730,GO:0005829,GO:0016423,GO:0030488" RNA binding|protein binding|nucleolus|cytosol|tRNA (guanine) methyltransferase activity|tRNA methylation THYN1 895.3146279 822.1143344 968.5149215 1.178078135 0.236435227 0.511535384 1 31.93036104 39.23682471 29087 thymocyte nuclear protein 1 GO:0005634 nucleus TIA1 1139.825982 1170.244232 1109.407733 0.948013845 -0.077019967 0.825318328 1 10.8530932 10.73208594 7072 TIA1 cytotoxic granule associated RNA binding protein "GO:0001818,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0008143,GO:0008543,GO:0010494,GO:0017148,GO:0035925,GO:0048024,GO:0097165,GO:1903608,GO:1904037,GO:1990904" "negative regulation of cytokine production|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|poly(A) binding|fibroblast growth factor receptor signaling pathway|cytoplasmic stress granule|negative regulation of translation|mRNA 3'-UTR AU-rich region binding|regulation of mRNA splicing, via spliceosome|nuclear stress granule|protein localization to cytoplasmic stress granule|positive regulation of epithelial cell apoptotic process|ribonucleoprotein complex" TIAF1 6.985925571 6.08973581 7.882115332 1.294327961 0.372203218 0.905012836 1 0.147641759 0.199328535 9220 TGFB1-induced anti-apoptotic factor 1 "GO:0003674,GO:0005515,GO:0005634,GO:0006915,GO:0007249,GO:0042802,GO:0043066" molecular_function|protein binding|nucleus|apoptotic process|I-kappaB kinase/NF-kappaB signaling|identical protein binding|negative regulation of apoptotic process TIAL1 1347.641061 1367.145689 1328.136434 0.971466643 -0.041763636 0.903280445 1 16.60060086 16.82161273 7073 TIA1 cytotoxic granule associated RNA binding protein like 1 "GO:0003677,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0006357,GO:0006915,GO:0006952,GO:0008543,GO:0010494,GO:1990904" DNA binding|RNA binding|nucleus|nucleoplasm|cytoplasm|lysosome|regulation of transcription by RNA polymerase II|apoptotic process|defense response|fibroblast growth factor receptor signaling pathway|cytoplasmic stress granule|ribonucleoprotein complex TIAM1 228.3396068 219.2304892 237.4487244 1.083100828 0.115167553 0.830712039 1 1.171228996 1.323203476 7074 TIAM Rac1 associated GEF 1 "GO:0003300,GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0005874,GO:0005886,GO:0005911,GO:0006915,GO:0007160,GO:0007186,GO:0007264,GO:0008017,GO:0008284,GO:0008289,GO:0010717,GO:0010718,GO:0016020,GO:0016477,GO:0016601,GO:0019900,GO:0030335,GO:0030971,GO:0031234,GO:0032092,GO:0032587,GO:0034622,GO:0042220,GO:0043025,GO:0043065,GO:0043197,GO:0043507,GO:0044291,GO:0044295,GO:0044304,GO:0045202,GO:0048013,GO:0050772,GO:0051056,GO:0060071,GO:0061003,GO:0061178,GO:0070372,GO:0072657,GO:0090630,GO:0098978,GO:0098989,GO:0099147,GO:1904268,GO:1904338,GO:1905274,GO:1990138,GO:2000050" "cardiac muscle hypertrophy|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|microtubule|plasma membrane|cell-cell junction|apoptotic process|cell-matrix adhesion|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|microtubule binding|positive regulation of cell population proliferation|lipid binding|regulation of epithelial to mesenchymal transition|positive regulation of epithelial to mesenchymal transition|membrane|cell migration|Rac protein signal transduction|kinase binding|positive regulation of cell migration|receptor tyrosine kinase binding|extrinsic component of cytoplasmic side of plasma membrane|positive regulation of protein binding|ruffle membrane|cellular protein-containing complex assembly|response to cocaine|neuronal cell body|positive regulation of apoptotic process|dendritic spine|positive regulation of JUN kinase activity|cell-cell contact zone|axonal growth cone|main axon|synapse|ephrin receptor signaling pathway|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|Wnt signaling pathway, planar cell polarity pathway|positive regulation of dendritic spine morphogenesis|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of ERK1 and ERK2 cascade|protein localization to membrane|activation of GTPase activity|glutamatergic synapse|NMDA selective glutamate receptor signaling pathway|extrinsic component of postsynaptic density membrane|positive regulation of Schwann cell chemotaxis|regulation of dopaminergic neuron differentiation|regulation of modification of postsynaptic actin cytoskeleton|neuron projection extension|regulation of non-canonical Wnt signaling pathway" "hsa04014,hsa04015,hsa04024,hsa04062,hsa04530,hsa04810,hsa05205" Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Tight junction|Regulation of actin cytoskeleton|Proteoglycans in cancer TIAM2 6.000661155 6.08973581 5.911586499 0.970745971 -0.042834281 1 1 0.047773178 0.048373293 26230 TIAM Rac1 associated GEF 2 "GO:0005096,GO:0005829,GO:0007186,GO:0007264,GO:0016020,GO:0019216,GO:0030027,GO:0030175,GO:0030426,GO:0043065,GO:0043204,GO:0045202,GO:0050772,GO:0051056,GO:0070062,GO:0090630" GTPase activator activity|cytosol|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|membrane|regulation of lipid metabolic process|lamellipodium|filopodium|growth cone|positive regulation of apoptotic process|perikaryon|synapse|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|extracellular exosome|activation of GTPase activity TICAM1 448.3193118 439.4759343 457.1626893 1.040245105 0.056923499 0.897416434 1 8.292811362 8.998153487 148022 toll like receptor adaptor molecule 1 "GO:0002281,GO:0002735,GO:0002756,GO:0005515,GO:0005739,GO:0005776,GO:0005829,GO:0006954,GO:0007249,GO:0010008,GO:0010508,GO:0010628,GO:0016032,GO:0019901,GO:0030890,GO:0031398,GO:0031663,GO:0032092,GO:0032722,GO:0032728,GO:0032755,GO:0032760,GO:0032816,GO:0034128,GO:0034138,GO:0035666,GO:0043123,GO:0043254,GO:0043330,GO:0045087,GO:0045429,GO:0051092,GO:0051607,GO:0070266,GO:0071222,GO:0097190,GO:0097342,GO:0140052,GO:1900017" macrophage activation involved in immune response|positive regulation of myeloid dendritic cell cytokine production|MyD88-independent toll-like receptor signaling pathway|protein binding|mitochondrion|autophagosome|cytosol|inflammatory response|I-kappaB kinase/NF-kappaB signaling|endosome membrane|positive regulation of autophagy|positive regulation of gene expression|viral process|protein kinase binding|positive regulation of B cell proliferation|positive regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|positive regulation of protein binding|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell activation|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of protein-containing complex assembly|response to exogenous dsRNA|innate immune response|positive regulation of nitric oxide biosynthetic process|positive regulation of NF-kappaB transcription factor activity|defense response to virus|necroptotic process|cellular response to lipopolysaccharide|apoptotic signaling pathway|ripoptosome|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of cytokine production involved in inflammatory response "hsa04064,hsa04217,hsa04620,hsa04621,hsa05133,hsa05135,hsa05142,hsa05160,hsa05161,hsa05164,hsa05165,hsa05167,hsa05168,hsa05235" NF-kappa B signaling pathway|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Pertussis|Yersinia infection|Chagas disease|Hepatitis C|Hepatitis B|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer TICAM2 12.52364607 14.20938356 10.83790858 0.762728977 -0.390757585 0.812815113 1 0.224681595 0.178753138 353376 toll like receptor adaptor molecule 2 "GO:0001891,GO:0002756,GO:0005515,GO:0005783,GO:0005793,GO:0005794,GO:0005886,GO:0006886,GO:0006888,GO:0006909,GO:0006954,GO:0007030,GO:0007249,GO:0010008,GO:0030134,GO:0030667,GO:0031901,GO:0031902,GO:0034128,GO:0034142,GO:0034145,GO:0035666,GO:0035669,GO:0042995,GO:0043123,GO:0043312,GO:0045087,GO:0070266,GO:0071222,GO:0097190,GO:2000494" phagocytic cup|MyD88-independent toll-like receptor signaling pathway|protein binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|phagocytosis|inflammatory response|Golgi organization|I-kappaB kinase/NF-kappaB signaling|endosome membrane|COPII-coated ER to Golgi transport vesicle|secretory granule membrane|early endosome membrane|late endosome membrane|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 4 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|TRAM-dependent toll-like receptor 4 signaling pathway|cell projection|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|innate immune response|necroptotic process|cellular response to lipopolysaccharide|apoptotic signaling pathway|positive regulation of interleukin-18-mediated signaling pathway "hsa04064,hsa04217,hsa04620,hsa05133,hsa05161,hsa05235" NF-kappa B signaling pathway|Necroptosis|Toll-like receptor signaling pathway|Pertussis|Hepatitis B|PD-L1 expression and PD-1 checkpoint pathway in cancer TICRR 1127.067525 1106.302006 1147.833045 1.037540418 0.053167539 0.880048412 1 8.254315525 8.933096379 90381 TOPBP1 interacting checkpoint and replication regulator "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006281,GO:0007093,GO:0007095,GO:0010212,GO:0030174,GO:0033314,GO:0043231" chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|DNA replication|DNA repair|mitotic cell cycle checkpoint|mitotic G2 DNA damage checkpoint|response to ionizing radiation|regulation of DNA-dependent DNA replication initiation|mitotic DNA replication checkpoint|intracellular membrane-bounded organelle TIE1 44.98739128 78.15160956 11.823173 0.151285086 -2.724658321 0.003743576 0.21983998 0.778694338 0.122879395 7075 tyrosine kinase with immunoglobulin like and EGF like domains 1 "GO:0001525,GO:0001570,GO:0001701,GO:0001936,GO:0003180,GO:0004714,GO:0005515,GO:0005524,GO:0005887,GO:0007165,GO:0007169,GO:0007275,GO:0007498,GO:0016525,GO:0018108,GO:0030336,GO:0032526,GO:0033674,GO:0043235,GO:0045026,GO:0045766,GO:0048771,GO:0060836,GO:0060854,GO:1901201" angiogenesis|vasculogenesis|in utero embryonic development|regulation of endothelial cell proliferation|aortic valve morphogenesis|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|integral component of plasma membrane|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|mesoderm development|negative regulation of angiogenesis|peptidyl-tyrosine phosphorylation|negative regulation of cell migration|response to retinoic acid|positive regulation of kinase activity|receptor complex|plasma membrane fusion|positive regulation of angiogenesis|tissue remodeling|lymphatic endothelial cell differentiation|branching involved in lymph vessel morphogenesis|regulation of extracellular matrix assembly TIFA 357.7991949 380.6084881 334.9899016 0.880143013 -0.18419013 0.684570488 1 4.63042931 4.250993433 92610 TRAF interacting protein with forkhead associated domain "GO:0002753,GO:0005515,GO:0005737,GO:0007249,GO:0043123,GO:0045087,GO:0051260" cytoplasmic pattern recognition receptor signaling pathway|protein binding|cytoplasm|I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|protein homooligomerization hsa05131 Shigellosis TIGAR 399.2193945 450.64045 347.798339 0.771786774 -0.373725774 0.389854649 1 2.780283716 2.238217967 57103 TP53 induced glycolysis regulatory phosphatase "GO:0002931,GO:0004083,GO:0004331,GO:0005515,GO:0005634,GO:0005737,GO:0005741,GO:0005829,GO:0006003,GO:0006914,GO:0006915,GO:0006974,GO:0009410,GO:0010332,GO:0010666,GO:0016311,GO:0030388,GO:0043069,GO:0043456,GO:0045739,GO:0045820,GO:0060576,GO:0071279,GO:0071456,GO:1901215,GO:1901525,GO:1902153,GO:1903301,GO:1904024,GO:2000378" "response to ischemia|bisphosphoglycerate 2-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|protein binding|nucleus|cytoplasm|mitochondrial outer membrane|cytosol|fructose 2,6-bisphosphate metabolic process|autophagy|apoptotic process|cellular response to DNA damage stimulus|response to xenobiotic stimulus|response to gamma radiation|positive regulation of cardiac muscle cell apoptotic process|dephosphorylation|fructose 1,6-bisphosphate metabolic process|negative regulation of programmed cell death|regulation of pentose-phosphate shunt|positive regulation of DNA repair|negative regulation of glycolytic process|intestinal epithelial cell development|cellular response to cobalt ion|cellular response to hypoxia|negative regulation of neuron death|negative regulation of mitophagy|regulation of response to DNA damage checkpoint signaling|positive regulation of hexokinase activity|negative regulation of glucose catabolic process to lactate via pyruvate|negative regulation of reactive oxygen species metabolic process" "hsa00051,hsa05230" Fructose and mannose metabolism|Central carbon metabolism in cancer TIGD1 80.83077628 70.03196182 91.62959074 1.308396743 0.387800073 0.601446765 1 0.531366563 0.725186326 200765 tigger transposable element derived 1 "GO:0003677,GO:0005515,GO:0005634" DNA binding|protein binding|nucleus TIGD2 217.24932 201.9762377 232.5224023 1.151236427 0.203184148 0.704051249 1 3.018407763 3.624585611 166815 tigger transposable element derived 2 "GO:0003677,GO:0005634" DNA binding|nucleus TIGD3 12.44941719 9.134603715 15.76423066 1.725770614 0.787240717 0.570104177 1 0.228123991 0.410648234 220359 tigger transposable element derived 3 "GO:0003677,GO:0005515,GO:0005634" DNA binding|protein binding|nucleus TIGD4 10.53827146 13.19442759 7.882115332 0.597382136 -0.743273999 0.622951235 1 0.211137823 0.131563131 201798 tigger transposable element derived 4 "GO:0003677,GO:0005515,GO:0005634" DNA binding|protein binding|nucleus TIGD5 598.3479648 626.2278325 570.4680972 0.910959347 -0.134541422 0.733728422 1 5.879909254 5.587088485 84948 tigger transposable element derived 5 "GO:0003674,GO:0003677,GO:0005575,GO:0005634,GO:0008150" molecular_function|DNA binding|cellular_component|nucleus|biological_process TIGD6 63.46988278 61.91231407 65.02745149 1.050315312 0.070822501 0.949575196 1 0.776340751 0.850526815 81789 tigger transposable element derived 6 "GO:0003677,GO:0005634" DNA binding|nucleus TIGD7 40.87090591 32.47859099 49.26322083 1.516790579 0.601021909 0.513748077 1 0.480831937 0.760737558 91151 tigger transposable element derived 7 "GO:0003677,GO:0005515,GO:0005634" DNA binding|protein binding|nucleus TIGIT 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.048971679 0 201633 T cell immunoreceptor with Ig and ITIM domains "GO:0005102,GO:0005515,GO:0005886,GO:0009986,GO:0016021,GO:0032695,GO:0032733,GO:0042802,GO:0050868" signaling receptor binding|protein binding|plasma membrane|cell surface|integral component of membrane|negative regulation of interleukin-12 production|positive regulation of interleukin-10 production|identical protein binding|negative regulation of T cell activation hsa04514 Cell adhesion molecules TIMELESS 2207.795456 1873.608718 2541.982195 1.356730555 0.440134231 0.169796668 1 18.3969895 26.03492291 8914 timeless circadian regulator "GO:0000076,GO:0000122,GO:0000785,GO:0002009,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0006974,GO:0007623,GO:0009582,GO:0030324,GO:0031298,GO:0035861,GO:0042127,GO:0042752,GO:0043111,GO:0044770,GO:0045892,GO:0048478,GO:0048754,GO:0051301,GO:0072711,GO:0072719,GO:1904976,GO:1905168,GO:2000781" "DNA replication checkpoint|negative regulation of transcription by RNA polymerase II|chromatin|morphogenesis of an epithelium|DNA binding|protein binding|nucleus|nucleoplasm|DNA replication|DNA repair|cellular response to DNA damage stimulus|circadian rhythm|detection of abiotic stimulus|lung development|replication fork protection complex|site of double-strand break|regulation of cell population proliferation|regulation of circadian rhythm|replication fork arrest|cell cycle phase transition|negative regulation of transcription, DNA-templated|replication fork protection|branching morphogenesis of an epithelial tube|cell division|cellular response to hydroxyurea|cellular response to cisplatin|cellular response to bleomycin|positive regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair" TIMM10 505.3646869 567.3603863 443.3689874 0.781459189 -0.355757563 0.383273318 1 17.45735239 14.22985946 26519 translocase of inner mitochondrial membrane 10 "GO:0005515,GO:0005739,GO:0005743,GO:0005744,GO:0005758,GO:0006626,GO:0007605,GO:0008270,GO:0042719,GO:0042803,GO:0045039,GO:0051087,GO:0072321,GO:0140318" protein binding|mitochondrion|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|mitochondrial intermembrane space|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|mitochondrial intermembrane space protein transporter complex|protein homodimerization activity|protein insertion into mitochondrial inner membrane|chaperone binding|chaperone-mediated protein transport|protein transporter activity TIMM10B 656.3961717 721.6336935 591.1586499 0.819194912 -0.28772134 0.453352593 1 13.10911076 11.20150582 26515 translocase of inner mitochondrial membrane 10B "GO:0005515,GO:0005743,GO:0005758,GO:0006626,GO:0007160,GO:0042719,GO:0042721,GO:0045039,GO:0046872,GO:0140318" protein binding|mitochondrial inner membrane|mitochondrial intermembrane space|protein targeting to mitochondrion|cell-matrix adhesion|mitochondrial intermembrane space protein transporter complex|TIM22 mitochondrial import inner membrane insertion complex|protein insertion into mitochondrial inner membrane|metal ion binding|protein transporter activity TIMM13 848.70212 902.2958559 795.1083842 0.881205847 -0.182449027 0.616761151 1 27.46280168 25.2428357 26517 translocase of inner mitochondrial membrane 13 "GO:0001650,GO:0005515,GO:0005739,GO:0005743,GO:0006626,GO:0007605,GO:0008270,GO:0042719,GO:0045039,GO:0072321" fibrillar center|protein binding|mitochondrion|mitochondrial inner membrane|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|mitochondrial intermembrane space protein transporter complex|protein insertion into mitochondrial inner membrane|chaperone-mediated protein transport TIMM17A 1174.260256 1234.186458 1114.334055 0.90288955 -0.147378581 0.668872138 1 37.88314553 35.67767858 10440 translocase of inner mitochondrial membrane 17A "GO:0005654,GO:0005739,GO:0005743,GO:0005744,GO:0006626,GO:0008320,GO:0010954,GO:0030150,GO:0031305" nucleoplasm|mitochondrion|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|positive regulation of protein processing|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM17B 746.1024926 691.1850145 801.0199707 1.158908185 0.212766273 0.569328068 1 31.82371148 38.46943327 10245 translocase of inner mitochondrial membrane 17B "GO:0005515,GO:0005743,GO:0005744,GO:0006626,GO:0008320,GO:0030150,GO:0031305" protein binding|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM21 491.8948705 623.1829646 360.6067765 0.578653136 -0.789229288 0.055014304 1 10.21424553 6.165105798 29090 translocase of inner mitochondrial membrane 21 "GO:0003674,GO:0005515,GO:0005744,GO:0016021,GO:0030150,GO:0032981,GO:0033617" molecular_function|protein binding|TIM23 mitochondrial import inner membrane translocase complex|integral component of membrane|protein import into mitochondrial matrix|mitochondrial respiratory chain complex I assembly|mitochondrial cytochrome c oxidase assembly TIMM22 621.3356535 648.5568638 594.1144432 0.916056057 -0.12649221 0.747137887 1 10.32278981 9.863591205 29928 translocase of inner mitochondrial membrane 22 "GO:0005515,GO:0005743,GO:0006626,GO:0008320,GO:0016021,GO:0030943,GO:0042721,GO:0045039,GO:0071806,GO:0140318" protein binding|mitochondrial inner membrane|protein targeting to mitochondrion|protein transmembrane transporter activity|integral component of membrane|mitochondrion targeting sequence binding|TIM22 mitochondrial import inner membrane insertion complex|protein insertion into mitochondrial inner membrane|protein transmembrane transport|protein transporter activity TIMM23 1397.4657 1439.207563 1355.723837 0.941993269 -0.086211344 0.79826695 1 61.25276122 60.18515736 100287932 translocase of inner mitochondrial membrane 23 "GO:0005515,GO:0005739,GO:0005743,GO:0005744,GO:0005758,GO:0006626,GO:0008320,GO:0030150,GO:0031305" protein binding|mitochondrion|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|mitochondrial intermembrane space|protein targeting to mitochondrion|protein transmembrane transporter activity|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM23B 281.8826165 276.0680234 287.6972096 1.042124351 0.059527436 0.90908652 1 5.603956503 6.091583889 100652748 translocase of inner mitochondrial membrane 23 homolog B "GO:0003674,GO:0005575,GO:0005744,GO:0008150,GO:0008320,GO:0030150,GO:0031305" molecular_function|cellular_component|TIM23 mitochondrial import inner membrane translocase complex|biological_process|protein transmembrane transporter activity|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM29 203.2747473 223.290313 183.2591815 0.820721593 -0.285035184 0.598988762 1 8.395595126 7.187258686 90580 translocase of inner mitochondrial membrane 29 "GO:0005515,GO:0005743,GO:0005758,GO:0016021,GO:0042721,GO:0045039,GO:0140318" protein binding|mitochondrial inner membrane|mitochondrial intermembrane space|integral component of membrane|TIM22 mitochondrial import inner membrane insertion complex|protein insertion into mitochondrial inner membrane|protein transporter activity TIMM44 463.5557755 504.4331163 422.6784347 0.837927608 -0.255102485 0.542034146 1 13.86204981 12.11573832 10469 translocase of inner mitochondrial membrane 44 "GO:0001650,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005759,GO:0006626,GO:0030150,GO:0051087" fibrillar center|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|protein targeting to mitochondrion|protein import into mitochondrial matrix|chaperone binding TIMM50 778.8010486 804.8600829 752.7420142 0.935245803 -0.096582509 0.796393109 1 27.24821111 26.58151275 92609 translocase of inner mitochondrial membrane 50 "GO:0001836,GO:0003723,GO:0004721,GO:0004722,GO:0004725,GO:0005134,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005744,GO:0006470,GO:0007006,GO:0016021,GO:0016607,GO:0030150,GO:0035335,GO:0043021" release of cytochrome c from mitochondria|RNA binding|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|interleukin-2 receptor binding|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|protein dephosphorylation|mitochondrial membrane organization|integral component of membrane|nuclear speck|protein import into mitochondrial matrix|peptidyl-tyrosine dephosphorylation|ribonucleoprotein complex binding TIMM8A 312.3906787 341.0252054 283.756152 0.832067975 -0.265226703 0.57268531 1 5.852837542 5.079736749 1678 translocase of inner mitochondrial membrane 8A "GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0007399,GO:0042802,GO:0046872,GO:0072321" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|nervous system development|identical protein binding|metal ion binding|chaperone-mediated protein transport TIMM8B 627.446916 763.2468882 491.6469439 0.644151914 -0.634527128 0.101424028 1 49.55866963 33.2984387 26521 translocase of inner mitochondrial membrane 8 homolog B "GO:0005615,GO:0005743,GO:0006626,GO:0007605,GO:0008270,GO:0042719,GO:0045039,GO:0072321,GO:0140318" extracellular space|mitochondrial inner membrane|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|mitochondrial intermembrane space protein transporter complex|protein insertion into mitochondrial inner membrane|chaperone-mediated protein transport|protein transporter activity TIMM9 424.4205876 422.2216828 426.6194924 1.010415878 0.014949215 0.978199703 1 17.06627193 17.9868351 26520 translocase of inner mitochondrial membrane 9 "GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0006626,GO:0007605,GO:0008270,GO:0042719,GO:0042803,GO:0045039,GO:0051087,GO:0072321,GO:0140318" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|mitochondrial intermembrane space protein transporter complex|protein homodimerization activity|protein insertion into mitochondrial inner membrane|chaperone binding|chaperone-mediated protein transport|protein transporter activity TIMMDC1 1244.585174 1259.560357 1229.609992 0.976221572 -0.034719463 0.921063464 1 26.56904982 27.0545524 51300 translocase of inner mitochondrial membrane domain containing 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0016021,GO:0032981" protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex I assembly TIMP1 6540.298788 5766.979812 7313.617764 1.26818855 0.342769256 0.293449804 1 366.4707438 484.7737186 7076 TIMP metallopeptidase inhibitor 1 "GO:0001775,GO:0002020,GO:0002248,GO:0002576,GO:0005125,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005788,GO:0007568,GO:0008083,GO:0008191,GO:0008270,GO:0008284,GO:0009725,GO:0010033,GO:0010951,GO:0019221,GO:0022617,GO:0030414,GO:0031012,GO:0031093,GO:0034097,GO:0043066,GO:0043086,GO:0043434,GO:0043687,GO:0044267,GO:0051045,GO:0051216,GO:0070062,GO:0071492,GO:1901164,GO:1905049,GO:2001044" cell activation|protease binding|connective tissue replacement involved in inflammatory response wound healing|platelet degranulation|cytokine activity|protein binding|extracellular region|basement membrane|extracellular space|endoplasmic reticulum lumen|aging|growth factor activity|metalloendopeptidase inhibitor activity|zinc ion binding|positive regulation of cell population proliferation|response to hormone|response to organic substance|negative regulation of endopeptidase activity|cytokine-mediated signaling pathway|extracellular matrix disassembly|peptidase inhibitor activity|extracellular matrix|platelet alpha granule lumen|response to cytokine|negative regulation of apoptotic process|negative regulation of catalytic activity|response to peptide hormone|post-translational protein modification|cellular protein metabolic process|negative regulation of membrane protein ectodomain proteolysis|cartilage development|extracellular exosome|cellular response to UV-A|negative regulation of trophoblast cell migration|negative regulation of metallopeptidase activity|regulation of integrin-mediated signaling pathway hsa04066 HIF-1 signaling pathway TIMP2 5487.140448 5402.61062 5571.670276 1.031292216 0.044453177 0.890906625 1 74.92419732 80.59716546 7077 TIMP metallopeptidase inhibitor 2 "GO:0002020,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0007417,GO:0007568,GO:0008191,GO:0008270,GO:0008285,GO:0009725,GO:0009986,GO:0010033,GO:0010951,GO:0022617,GO:0030414,GO:0030426,GO:0031012,GO:0032487,GO:0034097,GO:0035580,GO:0042493,GO:0043025,GO:0043312,GO:0043410,GO:0045666,GO:0045762,GO:0045930,GO:0046580,GO:0051045,GO:0062023,GO:1904724,GO:1904813,GO:1905049" protease binding|integrin binding|protein binding|extracellular region|extracellular space|central nervous system development|aging|metalloendopeptidase inhibitor activity|zinc ion binding|negative regulation of cell population proliferation|response to hormone|cell surface|response to organic substance|negative regulation of endopeptidase activity|extracellular matrix disassembly|peptidase inhibitor activity|growth cone|extracellular matrix|regulation of Rap protein signal transduction|response to cytokine|specific granule lumen|response to drug|neuronal cell body|neutrophil degranulation|positive regulation of MAPK cascade|positive regulation of neuron differentiation|positive regulation of adenylate cyclase activity|negative regulation of mitotic cell cycle|negative regulation of Ras protein signal transduction|negative regulation of membrane protein ectodomain proteolysis|collagen-containing extracellular matrix|tertiary granule lumen|ficolin-1-rich granule lumen|negative regulation of metallopeptidase activity TIMP3 88.73713996 139.0489677 38.42531225 0.276343743 -1.855464145 0.010386906 0.432539484 1.531942501 0.441578613 7078 TIMP metallopeptidase inhibitor 3 "GO:0002020,GO:0002576,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0007601,GO:0008191,GO:0009725,GO:0010033,GO:0010951,GO:0031012,GO:0031089,GO:0034097,GO:0046872,GO:0051045,GO:0062023,GO:0070373,GO:1903984,GO:1904684" protease binding|platelet degranulation|protein binding|extracellular region|extracellular space|nucleus|visual perception|metalloendopeptidase inhibitor activity|response to hormone|response to organic substance|negative regulation of endopeptidase activity|extracellular matrix|platelet dense granule lumen|response to cytokine|metal ion binding|negative regulation of membrane protein ectodomain proteolysis|collagen-containing extracellular matrix|negative regulation of ERK1 and ERK2 cascade|positive regulation of TRAIL-activated apoptotic signaling pathway|negative regulation of metalloendopeptidase activity "hsa05205,hsa05206" Proteoglycans in cancer|MicroRNAs in cancer TIMP4 116.1167028 124.8395841 107.3938214 0.860254559 -0.217164462 0.745591256 1 5.295380676 4.751602466 7079 TIMP metallopeptidase inhibitor 4 "GO:0002020,GO:0005615,GO:0007219,GO:0007417,GO:0008150,GO:0008191,GO:0009725,GO:0010033,GO:0010951,GO:0030017,GO:0031012,GO:0032496,GO:0034097,GO:0042493,GO:0042698,GO:0043434,GO:0046872,GO:0051045" protease binding|extracellular space|Notch signaling pathway|central nervous system development|biological_process|metalloendopeptidase inhibitor activity|response to hormone|response to organic substance|negative regulation of endopeptidase activity|sarcomere|extracellular matrix|response to lipopolysaccharide|response to cytokine|response to drug|ovulation cycle|response to peptide hormone|metal ion binding|negative regulation of membrane protein ectodomain proteolysis TINAGL1 2903.044254 3399.087538 2407.00097 0.708131504 -0.497910794 0.118136318 1 72.27195321 53.3825896 64129 tubulointerstitial nephritis antigen like 1 "GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0006508,GO:0008234,GO:0016197,GO:0043236,GO:0062023,GO:0070062" extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|lysosome|proteolysis|cysteine-type peptidase activity|endosomal transport|laminin binding|collagen-containing extracellular matrix|extracellular exosome TINF2 1036.558295 913.4603715 1159.656218 1.269520008 0.344283133 0.325798104 1 21.50792437 28.4809178 26277 TERF1 interacting nuclear factor 2 "GO:0000781,GO:0000783,GO:0003677,GO:0005515,GO:0005654,GO:0010370,GO:0010836,GO:0016233,GO:0016363,GO:0016604,GO:0032202,GO:0032211,GO:0042162,GO:0050680,GO:0070187,GO:0070198,GO:1904356" "chromosome, telomeric region|nuclear telomere cap complex|DNA binding|protein binding|nucleoplasm|perinucleolar chromocenter|negative regulation of protein ADP-ribosylation|telomere capping|nuclear matrix|nuclear body|telomere assembly|negative regulation of telomere maintenance via telomerase|telomeric DNA binding|negative regulation of epithelial cell proliferation|shelterin complex|protein localization to chromosome, telomeric region|regulation of telomere maintenance via telomere lengthening" TIPARP 725.8412296 552.1360468 899.5464123 1.629211528 0.704173927 0.060811057 1 6.416645927 10.9043926 25976 TCDD inducible poly(ADP-ribose) polymerase "GO:0000987,GO:0001570,GO:0001822,GO:0003950,GO:0005634,GO:0006471,GO:0008209,GO:0008210,GO:0008585,GO:0009791,GO:0010629,GO:0030097,GO:0045732,GO:0046872,GO:0048008,GO:0048705,GO:0048745,GO:0060021,GO:0060325,GO:0070213,GO:0071407,GO:0140289,GO:1904612,GO:1990404" "cis-regulatory region sequence-specific DNA binding|vasculogenesis|kidney development|NAD+ ADP-ribosyltransferase activity|nucleus|protein ADP-ribosylation|androgen metabolic process|estrogen metabolic process|female gonad development|post-embryonic development|negative regulation of gene expression|hemopoiesis|positive regulation of protein catabolic process|metal ion binding|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|smooth muscle tissue development|roof of mouth development|face morphogenesis|protein auto-ADP-ribosylation|cellular response to organic cyclic compound|protein mono-ADP-ribosylation|response to 2,3,7,8-tetrachlorodibenzodioxine|protein ADP-ribosylase activity" TIPIN 207.8272033 231.4099608 184.2444459 0.796182002 -0.328829836 0.539843448 1 3.27926641 2.723359573 54962 TIMELESS interacting protein "GO:0000076,GO:0000785,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0008284,GO:0009411,GO:0031298,GO:0031573,GO:0033262,GO:0043111,GO:0044770,GO:0048478,GO:0051301" DNA replication checkpoint|chromatin|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|DNA replication|positive regulation of cell population proliferation|response to UV|replication fork protection complex|intra-S DNA damage checkpoint|regulation of nuclear cell cycle DNA replication|replication fork arrest|cell cycle phase transition|replication fork protection|cell division TIPRL 1053.950118 1092.092622 1015.807613 0.930147858 -0.104468026 0.766748638 1 17.36052688 16.84344108 261726 TOR signaling pathway regulator "GO:0000077,GO:0005515,GO:0005829,GO:0031929,GO:0032515,GO:0043666" DNA damage checkpoint|protein binding|cytosol|TOR signaling|negative regulation of phosphoprotein phosphatase activity|regulation of phosphoprotein phosphatase activity TIRAP 278.748674 263.8885518 293.6087961 1.112624228 0.153966426 0.755718466 1 5.391296573 6.256877686 114609 TIR domain containing adaptor protein "GO:0002755,GO:0005080,GO:0005515,GO:0005546,GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007166,GO:0007250,GO:0030099,GO:0030139,GO:0030674,GO:0030890,GO:0031334,GO:0032496,GO:0032587,GO:0032648,GO:0032735,GO:0032738,GO:0032755,GO:0032757,GO:0032760,GO:0034137,GO:0034141,GO:0034145,GO:0035662,GO:0035663,GO:0035665,GO:0042802,GO:0043123,GO:0045087,GO:0045088,GO:0046330,GO:0050830,GO:0051092,GO:0070374,GO:0070935,GO:0071221,GO:0071223,GO:0090023,GO:2000340,GO:2000343" "MyD88-dependent toll-like receptor signaling pathway|protein kinase C binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|plasma membrane|inflammatory response|cell surface receptor signaling pathway|activation of NF-kappaB-inducing kinase activity|myeloid cell differentiation|endocytic vesicle|protein-macromolecule adaptor activity|positive regulation of B cell proliferation|positive regulation of protein-containing complex assembly|response to lipopolysaccharide|ruffle membrane|regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-15 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|Toll-like receptor 4 binding|Toll-like receptor 2 binding|TIRAP-dependent toll-like receptor 4 signaling pathway|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of innate immune response|positive regulation of JNK cascade|defense response to Gram-positive bacterium|positive regulation of NF-kappaB transcription factor activity|positive regulation of ERK1 and ERK2 cascade|3'-UTR-mediated mRNA stabilization|cellular response to bacterial lipopeptide|cellular response to lipoteichoic acid|positive regulation of neutrophil chemotaxis|positive regulation of chemokine (C-X-C motif) ligand 1 production|positive regulation of chemokine (C-X-C motif) ligand 2 production" "hsa04064,hsa04620,hsa05130,hsa05132,hsa05133,hsa05152,hsa05161,hsa05235" NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Tuberculosis|Hepatitis B|PD-L1 expression and PD-1 checkpoint pathway in cancer TJAP1 660.3453942 621.1530526 699.5377357 1.126192221 0.17145309 0.656064666 1 9.307458822 10.93350924 93643 tight junction associated protein 1 "GO:0005515,GO:0005794,GO:0005802,GO:0005923,GO:0007030" protein binding|Golgi apparatus|trans-Golgi network|bicellular tight junction|Golgi organization hsa04530 Tight junction TJP1 1174.754372 1032.21022 1317.298525 1.276192097 0.351845505 0.305407811 1 5.985551433 7.967758229 7082 tight junction protein 1 "GO:0002102,GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005921,GO:0005923,GO:0007043,GO:0008284,GO:0016323,GO:0030054,GO:0030335,GO:0031032,GO:0032991,GO:0034334,GO:0035329,GO:0035633,GO:0042995,GO:0043066,GO:0043296,GO:0045177,GO:0045216,GO:0045296,GO:0050839,GO:0051493,GO:0051497,GO:0070160,GO:0071896,GO:0090557,GO:0098609,GO:0150105,GO:1901888,GO:1902396,GO:1903672,GO:1905605,GO:2000049,GO:2000250,GO:2000810" podosome|protein binding|calmodulin binding|cytoplasm|cytosol|plasma membrane|adherens junction|gap junction|bicellular tight junction|cell-cell junction assembly|positive regulation of cell population proliferation|basolateral plasma membrane|cell junction|positive regulation of cell migration|actomyosin structure organization|protein-containing complex|adherens junction maintenance|hippo signaling|maintenance of blood-brain barrier|cell projection|negative regulation of apoptotic process|apical junction complex|apical part of cell|cell-cell junction organization|cadherin binding|cell adhesion molecule binding|regulation of cytoskeleton organization|negative regulation of stress fiber assembly|tight junction|protein localization to adherens junction|establishment of endothelial intestinal barrier|cell-cell adhesion|protein localization to cell-cell junction|regulation of cell junction assembly|protein localization to bicellular tight junction|positive regulation of sprouting angiogenesis|positive regulation of blood-brain barrier permeability|positive regulation of cell-cell adhesion mediated by cadherin|negative regulation of actin cytoskeleton reorganization|regulation of bicellular tight junction assembly "hsa04520,hsa04530,hsa04540,hsa05110,hsa05120,hsa05130" Adherens junction|Tight junction|Gap junction|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection TJP2 1144.880719 875.9070007 1413.854438 1.614160449 0.690783991 0.04552116 0.96408227 7.529124163 12.67672563 9414 tight junction protein 2 "GO:0004385,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0019904,GO:0030674,GO:0034109,GO:0035329,GO:0035633,GO:0044291,GO:0045216,GO:0045296,GO:0046037,GO:0046710,GO:0050839,GO:0050892,GO:0090557,GO:0090559,GO:0098609,GO:0150105,GO:1905605,GO:1990782" guanylate kinase activity|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|adherens junction|bicellular tight junction|protein domain specific binding|protein-macromolecule adaptor activity|homotypic cell-cell adhesion|hippo signaling|maintenance of blood-brain barrier|cell-cell contact zone|cell-cell junction organization|cadherin binding|GMP metabolic process|GDP metabolic process|cell adhesion molecule binding|intestinal absorption|establishment of endothelial intestinal barrier|regulation of membrane permeability|cell-cell adhesion|protein localization to cell-cell junction|positive regulation of blood-brain barrier permeability|protein tyrosine kinase binding "hsa04530,hsa05110" Tight junction|Vibrio cholerae infection TK1 2156.182643 1578.256531 2734.108756 1.732360172 0.79273891 0.01388482 0.521881214 51.83730579 93.66914189 7083 thymidine kinase 1 "GO:0004797,GO:0005515,GO:0005524,GO:0005829,GO:0006139,GO:0008270,GO:0009157,GO:0016310,GO:0042802,GO:0043097,GO:0046104,GO:0051289,GO:0071897" thymidine kinase activity|protein binding|ATP binding|cytosol|nucleobase-containing compound metabolic process|zinc ion binding|deoxyribonucleoside monophosphate biosynthetic process|phosphorylation|identical protein binding|pyrimidine nucleoside salvage|thymidine metabolic process|protein homotetramerization|DNA biosynthetic process "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes TK2 680.4581994 750.0524606 610.8639383 0.814428284 -0.29614043 0.436491579 1 7.14185206 6.06707868 7084 thymidine kinase 2 "GO:0004797,GO:0005524,GO:0005737,GO:0005759,GO:0006139,GO:0009157,GO:0009165,GO:0016310,GO:0019136,GO:0019206,GO:0043097,GO:0071897" thymidine kinase activity|ATP binding|cytoplasm|mitochondrial matrix|nucleobase-containing compound metabolic process|deoxyribonucleoside monophosphate biosynthetic process|nucleotide biosynthetic process|phosphorylation|deoxynucleoside kinase activity|nucleoside kinase activity|pyrimidine nucleoside salvage|DNA biosynthetic process "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes TKFC 711.6667347 829.2190262 594.1144432 0.716474688 -0.481012357 0.201373078 1 5.685260372 4.248808341 26007 triokinase and FMN cyclase "GO:0004371,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0019563,GO:0034012,GO:0039534,GO:0044262,GO:0045087,GO:0045088,GO:0046835,GO:0046872,GO:0050354,GO:0061624,GO:0070062" glycerone kinase activity|protein binding|ATP binding|nucleus|cytosol|glycerol catabolic process|FAD-AMP lyase (cyclizing) activity|negative regulation of MDA-5 signaling pathway|cellular carbohydrate metabolic process|innate immune response|regulation of innate immune response|carbohydrate phosphorylation|metal ion binding|triokinase activity|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|extracellular exosome "hsa00051,hsa00561,hsa04622" Fructose and mannose metabolism|Glycerolipid metabolism|RIG-I-like receptor signaling pathway TKT 11479.14725 9789.250315 13169.04419 1.345255639 0.427880355 0.209685857 1 158.8564544 222.9079798 7086 transketolase "GO:0000287,GO:0004802,GO:0005509,GO:0005515,GO:0005654,GO:0005777,GO:0005789,GO:0005829,GO:0005999,GO:0006098,GO:0009052,GO:0016604,GO:0030976,GO:0031982,GO:0040008,GO:0042803,GO:0046166,GO:0046390,GO:0070062" "magnesium ion binding|transketolase activity|calcium ion binding|protein binding|nucleoplasm|peroxisome|endoplasmic reticulum membrane|cytosol|xylulose biosynthetic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|nuclear body|thiamine pyrophosphate binding|vesicle|regulation of growth|protein homodimerization activity|glyceraldehyde-3-phosphate biosynthetic process|ribose phosphate biosynthetic process|extracellular exosome" hsa00030 Pentose phosphate pathway TLCD1 110.8489278 101.4955968 120.2022588 1.184310084 0.244046867 0.718393555 1 1.742506415 2.152562363 116238 TLC domain containing 1 "GO:0005515,GO:0005886,GO:0007009,GO:0016021,GO:0055088,GO:0055091,GO:0071709,GO:0097035" protein binding|plasma membrane|plasma membrane organization|integral component of membrane|lipid homeostasis|phospholipid homeostasis|membrane assembly|regulation of membrane lipid distribution TLCD2 230.7582305 216.1856213 245.3308397 1.134815712 0.182458031 0.728486227 1 1.860815612 2.202645524 727910 TLC domain containing 2 "GO:0005886,GO:0007009,GO:0016021,GO:0055088,GO:0055091,GO:0071709,GO:0097035" plasma membrane|plasma membrane organization|integral component of membrane|lipid homeostasis|phospholipid homeostasis|membrane assembly|regulation of membrane lipid distribution TLCD3A 1394.37877 1767.038341 1021.7192 0.578209978 -0.79033459 0.018665867 0.589604582 40.24022402 24.26955992 79850 TLC domain containing 3A "GO:0005515,GO:0005783,GO:0005886,GO:0008150,GO:0016021,GO:0055088" protein binding|endoplasmic reticulum|plasma membrane|biological_process|integral component of membrane|lipid homeostasis TLCD3B 77.8304457 66.98709391 88.67379749 1.323744505 0.404624696 0.590107731 1 0.836867289 1.155517941 83723 TLC domain containing 3B "GO:0000139,GO:0005783,GO:0005789,GO:0016021,GO:0045599,GO:0046513,GO:0050291,GO:0055088" Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|negative regulation of fat cell differentiation|ceramide biosynthetic process|sphingosine N-acyltransferase activity|lipid homeostasis TLCD4 360.3029339 248.6642123 471.9416555 1.897907428 0.924409625 0.039497205 0.912001904 1.75648049 3.477236948 148534 TLC domain containing 4 "GO:0003674,GO:0005515,GO:0005575,GO:0005783,GO:0008150,GO:0016021,GO:0055088" molecular_function|protein binding|cellular_component|endoplasmic reticulum|biological_process|integral component of membrane|lipid homeostasis TLCD4-RWDD3 10.0159477 11.16451565 8.867379749 0.794246703 -0.332340898 0.878848877 1 0.379237647 0.314183081 100527978 TLCD4-RWDD3 readthrough TLCD5 238.1477136 216.1856213 260.109806 1.203178104 0.266850218 0.603999162 1 2.546880451 3.196350598 219902 TLC domain containing 5 GO:0016021 integral component of membrane TLE1 1073.741759 1131.675905 1015.807613 0.897613539 -0.155833659 0.655765948 1 17.98412057 16.83815603 7088 "TLE family member 1, transcriptional corepressor" "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0007165,GO:0007275,GO:0008134,GO:0009887,GO:0010628,GO:0016055,GO:0030178,GO:0042802,GO:0043124,GO:0045892,GO:0070491,GO:0090090,GO:1904837,GO:1990907,GO:2000811" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|signal transduction|multicellular organism development|transcription factor binding|animal organ morphogenesis|positive regulation of gene expression|Wnt signaling pathway|negative regulation of Wnt signaling pathway|identical protein binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of transcription, DNA-templated|repressing transcription factor binding|negative regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex|negative regulation of anoikis" TLE2 295.2903282 249.6791682 340.9014881 1.365358154 0.449279441 0.345284923 1 4.158293014 5.922125499 7089 "TLE family member 2, transcriptional corepressor" "GO:0003714,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005667,GO:0005925,GO:0007165,GO:0009887,GO:0016055,GO:0016604,GO:0045892,GO:0070491,GO:0090090,GO:1904837" "transcription corepressor activity|protein binding|extracellular space|nucleus|nucleoplasm|transcription regulator complex|focal adhesion|signal transduction|animal organ morphogenesis|Wnt signaling pathway|nuclear body|negative regulation of transcription, DNA-templated|repressing transcription factor binding|negative regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly" TLE3 458.2110501 509.5078961 406.914204 0.798641605 -0.324379864 0.438564042 1 4.092099192 3.408898051 7090 "TLE family member 3, transcriptional corepressor" "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0007165,GO:0009887,GO:0016055,GO:0045892,GO:0070491,GO:0090090,GO:0120163,GO:1904837,GO:1990907" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|signal transduction|animal organ morphogenesis|Wnt signaling pathway|negative regulation of transcription, DNA-templated|repressing transcription factor binding|negative regulation of canonical Wnt signaling pathway|negative regulation of cold-induced thermogenesis|beta-catenin-TCF complex assembly|beta-catenin-TCF complex" TLE4 513.8987786 443.5357582 584.261799 1.31728229 0.397564544 0.327679981 1 4.090226047 5.620074759 7091 "TLE family member 4, transcriptional corepressor" "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0008150,GO:0016055,GO:0045892,GO:0070491,GO:0090090,GO:1904837,GO:1990907" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|biological_process|Wnt signaling pathway|negative regulation of transcription, DNA-templated|repressing transcription factor binding|negative regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex" TLE5 5172.806456 4726.649945 5618.962968 1.188783395 0.249485869 0.43803331 1 115.9264625 143.7478122 166 "TLE family member 5, transcriptional modulator" "GO:0000122,GO:0001501,GO:0003714,GO:0005515,GO:0005634,GO:0005667,GO:0007275,GO:0009887,GO:0010629,GO:0016055,GO:0031668,GO:0032091,GO:0040008,GO:0045892,GO:0060761,GO:0070491,GO:0070555,GO:0090090,GO:2000210" "negative regulation of transcription by RNA polymerase II|skeletal system development|transcription corepressor activity|protein binding|nucleus|transcription regulator complex|multicellular organism development|animal organ morphogenesis|negative regulation of gene expression|Wnt signaling pathway|cellular response to extracellular stimulus|negative regulation of protein binding|regulation of growth|negative regulation of transcription, DNA-templated|negative regulation of response to cytokine stimulus|repressing transcription factor binding|response to interleukin-1|negative regulation of canonical Wnt signaling pathway|positive regulation of anoikis" TLE6 26.55488032 30.44867905 22.66108158 0.744238577 -0.426162921 0.69944254 1 0.518010809 0.402130422 79816 "TLE family member 6, subcortical maternal complex member" "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005667,GO:0005938,GO:0007015,GO:0032991,GO:0040019,GO:0051293,GO:0051302,GO:0051643,GO:0051646,GO:0060136,GO:0070491,GO:0090090,GO:0106333" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|transcription regulator complex|cell cortex|actin filament organization|protein-containing complex|positive regulation of embryonic development|establishment of spindle localization|regulation of cell division|endoplasmic reticulum localization|mitochondrion localization|embryonic process involved in female pregnancy|repressing transcription factor binding|negative regulation of canonical Wnt signaling pathway|subcortical maternal complex TLK1 1125.634166 1109.346873 1141.921459 1.029363751 0.041752884 0.906319051 1 9.206047124 9.884574838 9874 tousled like kinase 1 "GO:0001672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006325,GO:0006468,GO:0006886,GO:0006974,GO:0007049,GO:0007059,GO:0018105,GO:0035556,GO:0106310,GO:0106311" regulation of chromatin assembly or disassembly|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromatin organization|protein phosphorylation|intracellular protein transport|cellular response to DNA damage stimulus|cell cycle|chromosome segregation|peptidyl-serine phosphorylation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity TLK2 1091.915211 1060.628987 1123.201435 1.058995604 0.082696601 0.813842067 1 7.370625208 8.141687243 11011 tousled like kinase 2 "GO:0001672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005882,GO:0006325,GO:0006468,GO:0006974,GO:0007049,GO:0007059,GO:0010507,GO:0018105,GO:0032435,GO:0035556,GO:0042802,GO:0048471,GO:0071480,GO:0106310,GO:0106311" regulation of chromatin assembly or disassembly|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|intermediate filament|chromatin organization|protein phosphorylation|cellular response to DNA damage stimulus|cell cycle|chromosome segregation|negative regulation of autophagy|peptidyl-serine phosphorylation|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|intracellular signal transduction|identical protein binding|perinuclear region of cytoplasm|cellular response to gamma radiation|protein serine kinase activity|protein threonine kinase activity TLL1 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.024473405 0.0148685 7092 tolloid like 1 "GO:0001501,GO:0004222,GO:0005509,GO:0005576,GO:0006508,GO:0008270,GO:0022617,GO:0030154" skeletal system development|metalloendopeptidase activity|calcium ion binding|extracellular region|proteolysis|zinc ion binding|extracellular matrix disassembly|cell differentiation TLL2 20.15066161 30.44867905 9.852644165 0.32358199 -1.627796782 0.149158412 1 0.227820679 0.07689417 7093 tolloid like 2 "GO:0004222,GO:0005509,GO:0005576,GO:0006508,GO:0007275,GO:0008270,GO:0022617,GO:0030154,GO:0048632" metalloendopeptidase activity|calcium ion binding|extracellular region|proteolysis|multicellular organism development|zinc ion binding|extracellular matrix disassembly|cell differentiation|negative regulation of skeletal muscle tissue growth TLN1 16799.4571 16752.86321 16846.05099 1.005562499 0.008002752 0.98220863 1 98.39654659 103.2059782 7094 talin 1 "GO:0001726,GO:0001786,GO:0002576,GO:0005178,GO:0005200,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0006936,GO:0007043,GO:0007044,GO:0007229,GO:0009986,GO:0016032,GO:0017166,GO:0030274,GO:0030866,GO:0032587,GO:0033622,GO:0035091,GO:0036498,GO:0045296,GO:0051015,GO:0070062,GO:0070527,GO:0098609" ruffle|phosphatidylserine binding|platelet degranulation|integrin binding|structural constituent of cytoskeleton|protein binding|extracellular region|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|muscle contraction|cell-cell junction assembly|cell-substrate junction assembly|integrin-mediated signaling pathway|cell surface|viral process|vinculin binding|LIM domain binding|cortical actin cytoskeleton organization|ruffle membrane|integrin activation|phosphatidylinositol binding|IRE1-mediated unfolded protein response|cadherin binding|actin filament binding|extracellular exosome|platelet aggregation|cell-cell adhesion "hsa04015,hsa04510,hsa04611,hsa05131,hsa05166" Rap1 signaling pathway|Focal adhesion|Platelet activation|Shigellosis|Human T-cell leukemia virus 1 infection TLN2 220.7692527 240.5445645 200.993941 0.83557881 -0.259152188 0.623689586 1 0.757255942 0.660003195 83660 talin 2 "GO:0001726,GO:0003779,GO:0005178,GO:0005198,GO:0005200,GO:0005515,GO:0005737,GO:0005886,GO:0005925,GO:0007010,GO:0007043,GO:0007155,GO:0015629,GO:0045202,GO:0051015,GO:0098609" ruffle|actin binding|integrin binding|structural molecule activity|structural constituent of cytoskeleton|protein binding|cytoplasm|plasma membrane|focal adhesion|cytoskeleton organization|cell-cell junction assembly|cell adhesion|actin cytoskeleton|synapse|actin filament binding|cell-cell adhesion "hsa04015,hsa04510,hsa04611,hsa05131,hsa05166" Rap1 signaling pathway|Focal adhesion|Platelet activation|Shigellosis|Human T-cell leukemia virus 1 infection TLNRD1 1377.408319 1179.378835 1575.437802 1.335819971 0.417725589 0.212926271 1 12.27525224 17.10386606 59274 talin rod domain containing 1 "GO:0001725,GO:0003779,GO:0005515,GO:0042802" stress fiber|actin binding|protein binding|identical protein binding TLR1 21.98757846 21.31407534 22.66108158 1.063197968 0.088410252 0.981992361 1 0.135341365 0.150093062 7096 toll like receptor 1 "GO:0001774,GO:0001775,GO:0002224,GO:0002755,GO:0004888,GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0016020,GO:0030670,GO:0032755,GO:0032757,GO:0032760,GO:0034130,GO:0034137,GO:0035354,GO:0035663,GO:0038023,GO:0038123,GO:0042116,GO:0042495,GO:0042802,GO:0045087,GO:0045121,GO:0050135,GO:0061809,GO:0071221,GO:0071723,GO:0071727" "microglial cell activation|cell activation|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|membrane|phagocytic vesicle membrane|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|toll-like receptor 1 signaling pathway|positive regulation of toll-like receptor 2 signaling pathway|Toll-like receptor 1-Toll-like receptor 2 protein complex|Toll-like receptor 2 binding|signaling receptor activity|toll-like receptor TLR1:TLR2 signaling pathway|macrophage activation|detection of triacyl bacterial lipopeptide|identical protein binding|innate immune response|membrane raft|NAD(P)+ nucleosidase activity|NAD+ nucleotidase, cyclic ADP-ribose generating|cellular response to bacterial lipopeptide|lipopeptide binding|cellular response to triacyl bacterial lipopeptide" "hsa04620,hsa05152" Toll-like receptor signaling pathway|Tuberculosis TLR2 220.9919394 255.768904 186.2149747 0.728059478 -0.457871781 0.38141598 1 1.371787852 1.041764952 7097 toll like receptor 2 "GO:0001530,GO:0001540,GO:0001666,GO:0001774,GO:0001775,GO:0001875,GO:0002224,GO:0002755,GO:0004888,GO:0005515,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0006691,GO:0006915,GO:0006954,GO:0006955,GO:0007165,GO:0007252,GO:0007612,GO:0008285,GO:0009636,GO:0009986,GO:0010628,GO:0014005,GO:0030177,GO:0030667,GO:0030670,GO:0031226,GO:0031663,GO:0032289,GO:0032570,GO:0032613,GO:0032722,GO:0032728,GO:0032733,GO:0032735,GO:0032741,GO:0032755,GO:0032757,GO:0032760,GO:0032868,GO:0034123,GO:0034134,GO:0035325,GO:0035354,GO:0038023,GO:0038123,GO:0038124,GO:0038187,GO:0042495,GO:0042496,GO:0042497,GO:0042802,GO:0042834,GO:0042995,GO:0043312,GO:0044297,GO:0044877,GO:0045087,GO:0045121,GO:0045944,GO:0046209,GO:0048714,GO:0050135,GO:0050729,GO:0050765,GO:0050830,GO:0051092,GO:0051770,GO:0051964,GO:0061809,GO:0070542,GO:0071221,GO:0071223,GO:0071346,GO:0071726,GO:0071727,GO:1901224,GO:1903974,GO:1904466" "lipopolysaccharide binding|amyloid-beta binding|response to hypoxia|microglial cell activation|cell activation|lipopolysaccharide immune receptor activity|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|protein binding|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|leukotriene metabolic process|apoptotic process|inflammatory response|immune response|signal transduction|I-kappaB phosphorylation|learning|negative regulation of cell population proliferation|response to toxic substance|cell surface|positive regulation of gene expression|microglia development|positive regulation of Wnt signaling pathway|secretory granule membrane|phagocytic vesicle membrane|intrinsic component of plasma membrane|lipopolysaccharide-mediated signaling pathway|central nervous system myelin formation|response to progesterone|interleukin-10 production|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|response to insulin|positive regulation of toll-like receptor signaling pathway|toll-like receptor 2 signaling pathway|Toll-like receptor binding|Toll-like receptor 1-Toll-like receptor 2 protein complex|signaling receptor activity|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|pattern recognition receptor activity|detection of triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|triacyl lipopeptide binding|identical protein binding|peptidoglycan binding|cell projection|neutrophil degranulation|cell body|protein-containing complex binding|innate immune response|membrane raft|positive regulation of transcription by RNA polymerase II|nitric oxide metabolic process|positive regulation of oligodendrocyte differentiation|NAD(P)+ nucleosidase activity|positive regulation of inflammatory response|negative regulation of phagocytosis|defense response to Gram-positive bacterium|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|negative regulation of synapse assembly|NAD+ nucleotidase, cyclic ADP-ribose generating|response to fatty acid|cellular response to bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to interferon-gamma|cellular response to diacyl bacterial lipopeptide|cellular response to triacyl bacterial lipopeptide|positive regulation of NIK/NF-kappaB signaling|positive regulation of cellular response to macrophage colony-stimulating factor stimulus|positive regulation of matrix metallopeptidase secretion" "hsa04145,hsa04151,hsa04620,hsa05132,hsa05134,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05171,hsa05205,hsa05235,hsa05321,hsa05323" Phagosome|PI3K-Akt signaling pathway|Toll-like receptor signaling pathway|Salmonella infection|Legionellosis|Leishmaniasis|Chagas disease|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease|Rheumatoid arthritis TLR3 85.48715279 85.25630134 85.71800424 1.005415469 0.007791792 1 1 0.717860498 0.752838029 7098 toll like receptor 3 "GO:0000139,GO:0001774,GO:0002224,GO:0002730,GO:0002756,GO:0003725,GO:0004888,GO:0005515,GO:0005615,GO:0005737,GO:0005765,GO:0005769,GO:0005789,GO:0005887,GO:0006954,GO:0006972,GO:0007165,GO:0007249,GO:0007250,GO:0007252,GO:0008584,GO:0009597,GO:0009986,GO:0010008,GO:0010628,GO:0016020,GO:0031012,GO:0032722,GO:0032727,GO:0032728,GO:0032729,GO:0032735,GO:0032755,GO:0032757,GO:0032760,GO:0034123,GO:0034128,GO:0034138,GO:0034346,GO:0035458,GO:0035666,GO:0035690,GO:0036020,GO:0038023,GO:0042742,GO:0042802,GO:0043065,GO:0043123,GO:0043330,GO:0043331,GO:0045087,GO:0045671,GO:0045766,GO:0045944,GO:0046330,GO:0050729,GO:0051092,GO:0051607,GO:0070266,GO:0071260,GO:0071346,GO:0071360,GO:0097190,GO:0097191,GO:0097527,GO:1901224" Golgi membrane|microglial cell activation|toll-like receptor signaling pathway|regulation of dendritic cell cytokine production|MyD88-independent toll-like receptor signaling pathway|double-stranded RNA binding|transmembrane signaling receptor activity|protein binding|extracellular space|cytoplasm|lysosomal membrane|early endosome|endoplasmic reticulum membrane|integral component of plasma membrane|inflammatory response|hyperosmotic response|signal transduction|I-kappaB kinase/NF-kappaB signaling|activation of NF-kappaB-inducing kinase activity|I-kappaB phosphorylation|male gonad development|detection of virus|cell surface|endosome membrane|positive regulation of gene expression|membrane|extracellular matrix|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of toll-like receptor signaling pathway|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|positive regulation of type III interferon production|cellular response to interferon-beta|TRIF-dependent toll-like receptor signaling pathway|cellular response to drug|endolysosome membrane|signaling receptor activity|defense response to bacterium|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|response to dsRNA|innate immune response|negative regulation of osteoclast differentiation|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|defense response to virus|necroptotic process|cellular response to mechanical stimulus|cellular response to interferon-gamma|cellular response to exogenous dsRNA|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|necroptotic signaling pathway|positive regulation of NIK/NF-kappaB signaling "hsa04217,hsa04620,hsa05160,hsa05161,hsa05164,hsa05165,hsa05167,hsa05168,hsa05171" Necroptosis|Toll-like receptor signaling pathway|Hepatitis C|Hepatitis B|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19 TLR4 9.523315492 11.16451565 7.882115332 0.705997069 -0.5022659 0.780585832 1 0.044185616 0.032538666 7099 toll like receptor 4 "GO:0000187,GO:0001530,GO:0001540,GO:0001726,GO:0001875,GO:0001891,GO:0002218,GO:0002224,GO:0002322,GO:0002537,GO:0002730,GO:0002755,GO:0002756,GO:0004888,GO:0005102,GO:0005515,GO:0005737,GO:0005769,GO:0005794,GO:0005886,GO:0005887,GO:0006909,GO:0006954,GO:0006955,GO:0007249,GO:0007252,GO:0009897,GO:0009986,GO:0010008,GO:0010572,GO:0010628,GO:0010838,GO:0014002,GO:0016046,GO:0030890,GO:0031226,GO:0031663,GO:0032496,GO:0032497,GO:0032611,GO:0032689,GO:0032700,GO:0032707,GO:0032715,GO:0032720,GO:0032722,GO:0032727,GO:0032728,GO:0032729,GO:0032731,GO:0032732,GO:0032733,GO:0032735,GO:0032755,GO:0032757,GO:0032760,GO:0034128,GO:0034142,GO:0035666,GO:0038023,GO:0042088,GO:0042116,GO:0042742,GO:0042802,GO:0043032,GO:0043123,GO:0043235,GO:0045087,GO:0045348,GO:0045429,GO:0045671,GO:0045944,GO:0046330,GO:0046696,GO:0046982,GO:0048471,GO:0050135,GO:0050729,GO:0050829,GO:0051092,GO:0051770,GO:0060729,GO:0060907,GO:0061809,GO:0070266,GO:0070373,GO:0070374,GO:0070430,GO:0070434,GO:0071222,GO:0071223,GO:0071260,GO:0071346,GO:0097190,GO:0120163,GO:0140052,GO:1900017,GO:1900227,GO:1901224,GO:1903223,GO:1903428,GO:1903974,GO:1904466,GO:1904646,GO:2000343" "activation of MAPK activity|lipopolysaccharide binding|amyloid-beta binding|ruffle|lipopolysaccharide immune receptor activity|phagocytic cup|activation of innate immune response|toll-like receptor signaling pathway|B cell proliferation involved in immune response|nitric oxide production involved in inflammatory response|regulation of dendritic cell cytokine production|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|transmembrane signaling receptor activity|signaling receptor binding|protein binding|cytoplasm|early endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|phagocytosis|inflammatory response|immune response|I-kappaB kinase/NF-kappaB signaling|I-kappaB phosphorylation|external side of plasma membrane|cell surface|endosome membrane|positive regulation of platelet activation|positive regulation of gene expression|positive regulation of keratinocyte proliferation|astrocyte development|detection of fungus|positive regulation of B cell proliferation|intrinsic component of plasma membrane|lipopolysaccharide-mediated signaling pathway|response to lipopolysaccharide|detection of lipopolysaccharide|interleukin-1 beta production|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|signaling receptor activity|T-helper 1 type immune response|macrophage activation|defense response to bacterium|identical protein binding|positive regulation of macrophage activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|innate immune response|positive regulation of MHC class II biosynthetic process|positive regulation of nitric oxide biosynthetic process|negative regulation of osteoclast differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|lipopolysaccharide receptor complex|protein heterodimerization activity|perinuclear region of cytoplasm|NAD(P)+ nucleosidase activity|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|intestinal epithelial structure maintenance|positive regulation of macrophage cytokine production|NAD+ nucleotidase, cyclic ADP-ribose generating|necroptotic process|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|cellular response to mechanical stimulus|cellular response to interferon-gamma|apoptotic signaling pathway|negative regulation of cold-induced thermogenesis|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of cytokine production involved in inflammatory response|positive regulation of NLRP3 inflammasome complex assembly|positive regulation of NIK/NF-kappaB signaling|positive regulation of oxidative stress-induced neuron death|positive regulation of reactive oxygen species biosynthetic process|positive regulation of cellular response to macrophage colony-stimulating factor stimulus|positive regulation of matrix metallopeptidase secretion|cellular response to amyloid-beta|positive regulation of chemokine (C-X-C motif) ligand 2 production" "hsa04064,hsa04066,hsa04145,hsa04151,hsa04217,hsa04620,hsa04621,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05162,hsa05164,hsa05170,hsa05171,hsa05205,hsa05235,hsa05321,hsa05323" NF-kappa B signaling pathway|HIF-1 signaling pathway|Phagosome|PI3K-Akt signaling pathway|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Measles|Influenza A|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease|Rheumatoid arthritis TLR6 160.3442379 184.7219862 135.9664895 0.736060131 -0.442104465 0.447825506 1 1.204986726 0.925148582 10333 toll like receptor 6 "GO:0001540,GO:0001774,GO:0001775,GO:0002224,GO:0002755,GO:0004888,GO:0005102,GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0007250,GO:0010628,GO:0030670,GO:0032611,GO:0032717,GO:0032755,GO:0034136,GO:0034150,GO:0035355,GO:0035663,GO:0035666,GO:0038023,GO:0038124,GO:0042496,GO:0042742,GO:0042802,GO:0043032,GO:0043123,GO:0043235,GO:0043507,GO:0045087,GO:0045121,GO:0045429,GO:0046209,GO:0046982,GO:0050135,GO:0051092,GO:0061809,GO:0071221,GO:0071723,GO:0071726,GO:0140052,GO:1900017,GO:1900227,GO:1903223,GO:1903428,GO:1904646" "amyloid-beta binding|microglial cell activation|cell activation|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|signaling receptor binding|protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|activation of NF-kappaB-inducing kinase activity|positive regulation of gene expression|phagocytic vesicle membrane|interleukin-1 beta production|negative regulation of interleukin-8 production|positive regulation of interleukin-6 production|negative regulation of toll-like receptor 2 signaling pathway|toll-like receptor 6 signaling pathway|Toll-like receptor 2-Toll-like receptor 6 protein complex|Toll-like receptor 2 binding|TRIF-dependent toll-like receptor signaling pathway|signaling receptor activity|toll-like receptor TLR6:TLR2 signaling pathway|detection of diacyl bacterial lipopeptide|defense response to bacterium|identical protein binding|positive regulation of macrophage activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|positive regulation of JUN kinase activity|innate immune response|membrane raft|positive regulation of nitric oxide biosynthetic process|nitric oxide metabolic process|protein heterodimerization activity|NAD(P)+ nucleosidase activity|positive regulation of NF-kappaB transcription factor activity|NAD+ nucleotidase, cyclic ADP-ribose generating|cellular response to bacterial lipopeptide|lipopeptide binding|cellular response to diacyl bacterial lipopeptide|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of cytokine production involved in inflammatory response|positive regulation of NLRP3 inflammasome complex assembly|positive regulation of oxidative stress-induced neuron death|positive regulation of reactive oxygen species biosynthetic process|cellular response to amyloid-beta" "hsa04145,hsa04620,hsa05132,hsa05142,hsa05152" Phagosome|Toll-like receptor signaling pathway|Salmonella infection|Chagas disease|Tuberculosis TLR9 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.061341216 0.031055885 54106 toll like receptor 9 "GO:0000139,GO:0002224,GO:0002237,GO:0002639,GO:0002755,GO:0004888,GO:0005149,GO:0005576,GO:0005737,GO:0005764,GO:0005768,GO:0005783,GO:0005789,GO:0005886,GO:0006954,GO:0006955,GO:0007249,GO:0007252,GO:0010008,GO:0010628,GO:0016021,GO:0016323,GO:0016324,GO:0030277,GO:0030890,GO:0032009,GO:0032088,GO:0032640,GO:0032715,GO:0032717,GO:0032722,GO:0032725,GO:0032727,GO:0032728,GO:0032729,GO:0032733,GO:0032735,GO:0032741,GO:0032755,GO:0032757,GO:0032760,GO:0034122,GO:0034123,GO:0034162,GO:0034163,GO:0035197,GO:0036019,GO:0036020,GO:0038187,GO:0042742,GO:0042803,GO:0043123,GO:0043410,GO:0043507,GO:0045087,GO:0045322,GO:0045577,GO:0045944,GO:0046330,GO:0050729,GO:0050829,GO:0050871,GO:0051092,GO:0051607,GO:0051770,GO:1901224,GO:1901895" Golgi membrane|toll-like receptor signaling pathway|response to molecule of bacterial origin|positive regulation of immunoglobulin production|MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|interleukin-1 receptor binding|extracellular region|cytoplasm|lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|inflammatory response|immune response|I-kappaB kinase/NF-kappaB signaling|I-kappaB phosphorylation|endosome membrane|positive regulation of gene expression|integral component of membrane|basolateral plasma membrane|apical plasma membrane|maintenance of gastrointestinal epithelium|positive regulation of B cell proliferation|early phagosome|negative regulation of NF-kappaB transcription factor activity|tumor necrosis factor production|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|positive regulation of chemokine production|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|positive regulation of toll-like receptor signaling pathway|toll-like receptor 9 signaling pathway|regulation of toll-like receptor 9 signaling pathway|siRNA binding|endolysosome|endolysosome membrane|pattern recognition receptor activity|defense response to bacterium|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|innate immune response|unmethylated CpG binding|regulation of B cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of B cell activation|positive regulation of NF-kappaB transcription factor activity|defense response to virus|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of NIK/NF-kappaB signaling|negative regulation of ATPase-coupled calcium transmembrane transporter activity "hsa04620,hsa05132,hsa05142,hsa05143,hsa05144,hsa05152,hsa05162,hsa05168,hsa05235" Toll-like receptor signaling pathway|Salmonella infection|Chagas disease|African trypanosomiasis|Malaria|Tuberculosis|Measles|Herpes simplex virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer TM2D1 502.5858052 411.0571672 594.1144432 1.445332889 0.531401813 0.193101922 1 21.48461857 32.39003841 83941 TM2 domain containing 1 "GO:0001540,GO:0004930,GO:0005515,GO:0007186,GO:0016021,GO:0097190" amyloid-beta binding|G protein-coupled receptor activity|protein binding|G protein-coupled receptor signaling pathway|integral component of membrane|apoptotic signaling pathway TM2D2 619.7241449 639.4222601 600.0260297 0.938387771 -0.091743882 0.816491634 1 8.70316628 8.51874367 83877 TM2 domain containing 2 "GO:0005515,GO:0016021" protein binding|integral component of membrane TM2D3 593.4095186 591.7193296 595.0997076 1.005712807 0.008218385 0.988135962 1 13.95831233 14.64275588 80213 TM2 domain containing 3 "GO:0044214,GO:0045747,GO:0046331" spanning component of plasma membrane|positive regulation of Notch signaling pathway|lateral inhibition TM4SF1 2012.979088 1723.395234 2302.562941 1.336062034 0.417986994 0.194638893 1 51.13291672 71.25955717 4071 transmembrane 4 L six family member 1 "GO:0003674,GO:0005515,GO:0005887,GO:0008150,GO:0016021" molecular_function|protein binding|integral component of plasma membrane|biological_process|integral component of membrane TM4SF19 728.7198262 951.0137424 506.4259101 0.532511664 -0.90911497 0.015705876 0.552928428 46.94492308 26.07556252 116211 transmembrane 4 L six family member 19 "GO:0005515,GO:0016021" protein binding|integral component of membrane TM6SF1 32.98879058 32.47859099 33.49899016 1.031417594 0.04462856 0.999261389 1 0.257421918 0.276946567 53346 transmembrane 6 superfamily member 1 "GO:0003674,GO:0005765,GO:0008150,GO:0016021" molecular_function|lysosomal membrane|biological_process|integral component of membrane TM7SF2 389.4476602 557.2108266 221.6844937 0.397846709 -1.329715429 0.002673472 0.170123167 17.88388 7.421529996 7108 transmembrane 7 superfamily member 2 "GO:0005515,GO:0005637,GO:0005783,GO:0005789,GO:0005887,GO:0006695,GO:0016126,GO:0016627,GO:0030176,GO:0043231,GO:0043235,GO:0045540,GO:0050613,GO:0050661,GO:0055114" "protein binding|nuclear inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|cholesterol biosynthetic process|sterol biosynthetic process|oxidoreductase activity, acting on the CH-CH group of donors|integral component of endoplasmic reticulum membrane|intracellular membrane-bounded organelle|receptor complex|regulation of cholesterol biosynthetic process|delta14-sterol reductase activity|NADP binding|oxidation-reduction process" hsa00100 Steroid biosynthesis TM7SF3 1617.211832 1778.202857 1456.220808 0.818928393 -0.288190787 0.380641413 1 9.497964729 8.113204277 51768 transmembrane 7 superfamily member 3 "GO:0003674,GO:0005886,GO:0016021,GO:0032024,GO:0034620,GO:0043069,GO:0070062" molecular_function|plasma membrane|integral component of membrane|positive regulation of insulin secretion|cellular response to unfolded protein|negative regulation of programmed cell death|extracellular exosome TM9SF1 2239.335796 2278.576149 2200.095442 0.965557128 -0.050566475 0.875744019 1 45.3980502 45.72261961 10548 transmembrane 9 superfamily member 1 "GO:0000421,GO:0005765,GO:0006914,GO:0016020,GO:0016021,GO:0031410,GO:0072657" autophagosome membrane|lysosomal membrane|autophagy|membrane|integral component of membrane|cytoplasmic vesicle|protein localization to membrane TM9SF2 3794.076617 3827.398957 3760.754278 0.982587475 -0.025342245 0.937395065 1 56.7293693 58.14268843 9375 transmembrane 9 superfamily member 2 "GO:0005768,GO:0005856,GO:0005887,GO:0010008,GO:0016020,GO:0070062,GO:0072657,GO:0150051" endosome|cytoskeleton|integral component of plasma membrane|endosome membrane|membrane|extracellular exosome|protein localization to membrane|postsynaptic Golgi apparatus TM9SF3 10723.65556 10375.89486 11071.41625 1.067032424 0.093604016 0.782290129 1 80.85897383 89.99570258 56889 transmembrane 9 superfamily member 3 "GO:0016020,GO:0016021,GO:0072657" membrane|integral component of membrane|protein localization to membrane TM9SF4 4127.685124 4844.384837 3410.98541 0.704111156 -0.506124893 0.113087276 1 61.66147324 45.28673932 9777 transmembrane 9 superfamily member 4 "GO:0001666,GO:0005515,GO:0005769,GO:0005794,GO:0006909,GO:0007155,GO:0016020,GO:0016021,GO:0051453,GO:0070072,GO:0070863,GO:0072657,GO:2000010" response to hypoxia|protein binding|early endosome|Golgi apparatus|phagocytosis|cell adhesion|membrane|integral component of membrane|regulation of intracellular pH|vacuolar proton-transporting V-type ATPase complex assembly|positive regulation of protein exit from endoplasmic reticulum|protein localization to membrane|positive regulation of protein localization to cell surface TMA16 400.1655648 380.6084881 419.7226414 1.102767423 0.141128554 0.748856041 1 11.0214278 12.67761963 55319 translation machinery associated 16 homolog "GO:0005515,GO:0005634,GO:0005654,GO:0005730" protein binding|nucleus|nucleoplasm|nucleolus TMA7 1877.587378 1998.448302 1756.726455 0.879045234 -0.18599069 0.566212948 1 180.4177476 165.427006 51372 translation machinery associated 7 homolog GO:0002181 cytoplasmic translation TMBIM1 2152.862141 2024.837157 2280.887124 1.126454597 0.171789166 0.592769473 1 32.74293065 38.47221312 64114 transmembrane BAX inhibitor motif containing 1 "GO:0005123,GO:0005515,GO:0005765,GO:0005794,GO:0005886,GO:0010008,GO:0016021,GO:0035579,GO:0043086,GO:0043231,GO:0043312,GO:0070062,GO:1902042,GO:1902045,GO:1903077,GO:2000504" death receptor binding|protein binding|lysosomal membrane|Golgi apparatus|plasma membrane|endosome membrane|integral component of membrane|specific granule membrane|negative regulation of catalytic activity|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of Fas signaling pathway|negative regulation of protein localization to plasma membrane|positive regulation of blood vessel remodeling TMBIM4 917.5936787 930.714623 904.4727344 0.971804581 -0.041261861 0.911201982 1 15.62393513 15.83745154 51643 transmembrane BAX inhibitor motif containing 4 "GO:0000139,GO:0005515,GO:0005795,GO:0006915,GO:0016021,GO:0043066,GO:0050848" Golgi membrane|protein binding|Golgi stack|apoptotic process|integral component of membrane|negative regulation of apoptotic process|regulation of calcium-mediated signaling TMBIM6 19634.02126 16345.86587 22922.17665 1.402322571 0.487818245 0.179536819 1 225.084405 329.2374731 7009 transmembrane BAX inhibitor motif containing 6 "GO:0002638,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005887,GO:0006914,GO:0010523,GO:0016020,GO:0016021,GO:0019899,GO:0031625,GO:0031966,GO:0032091,GO:0032469,GO:0033119,GO:0034620,GO:0043066,GO:0060698,GO:0060702,GO:0070059,GO:1902065,GO:1902236,GO:1903298,GO:1990441,GO:2001234" negative regulation of immunoglobulin production|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|autophagy|negative regulation of calcium ion transport into cytosol|membrane|integral component of membrane|enzyme binding|ubiquitin protein ligase binding|mitochondrial membrane|negative regulation of protein binding|endoplasmic reticulum calcium ion homeostasis|negative regulation of RNA splicing|cellular response to unfolded protein|negative regulation of apoptotic process|endoribonuclease inhibitor activity|negative regulation of endoribonuclease activity|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|response to L-glutamate|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|negative regulation of apoptotic signaling pathway hsa05130 Pathogenic Escherichia coli infection TMC4 12.50880029 13.19442759 11.823173 0.896073204 -0.158311499 0.970376506 1 0.279252491 0.261009597 147798 transmembrane channel like 4 "GO:0005887,GO:0008381,GO:0034220,GO:0070062" integral component of plasma membrane|mechanosensitive ion channel activity|ion transmembrane transport|extracellular exosome TMC6 163.2312454 112.6601125 213.8023784 1.897764645 0.924301085 0.109720474 1 0.646407302 1.279571431 11322 transmembrane channel like 6 "GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0008150,GO:0008381,GO:0031965,GO:0034220,GO:0035579,GO:0043312,GO:0070062,GO:0070821" protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|biological_process|mechanosensitive ion channel activity|nuclear membrane|ion transmembrane transport|specific granule membrane|neutrophil degranulation|extracellular exosome|tertiary granule membrane TMC7 50.06489273 54.80762229 45.32216316 0.826931753 -0.274159827 0.763378665 1 0.591101516 0.509856161 79905 transmembrane channel like 7 "GO:0005887,GO:0008381,GO:0034220" integral component of plasma membrane|mechanosensitive ion channel activity|ion transmembrane transport TMC8 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.016657142 0.025299577 147138 transmembrane channel like 8 "GO:0001558,GO:0005515,GO:0005615,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005887,GO:0008381,GO:0031333,GO:0031965,GO:0032091,GO:0034220,GO:0043120,GO:0055069,GO:0070062,GO:0140311,GO:1902041" regulation of cell growth|protein binding|extracellular space|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral component of plasma membrane|mechanosensitive ion channel activity|negative regulation of protein-containing complex assembly|nuclear membrane|negative regulation of protein binding|ion transmembrane transport|tumor necrosis factor binding|zinc ion homeostasis|extracellular exosome|protein sequestering activity|regulation of extrinsic apoptotic signaling pathway via death domain receptors TMCC1 329.6355276 307.5316584 351.7393967 1.143750203 0.193771999 0.676841074 1 1.945708131 2.321265452 23023 transmembrane and coiled-coil domain family 1 "GO:0005515,GO:0005789,GO:0005791,GO:0005829,GO:0007029,GO:0012505,GO:0016021,GO:0016197,GO:0042802,GO:0090148,GO:0097750,GO:0140284,GO:0140285" protein binding|endoplasmic reticulum membrane|rough endoplasmic reticulum|cytosol|endoplasmic reticulum organization|endomembrane system|integral component of membrane|endosomal transport|identical protein binding|membrane fission|endosome membrane tubulation|endoplasmic reticulum-endosome membrane contact site|endosome fission TMCC2 313.5474114 251.7090802 375.3857427 1.49134764 0.576616596 0.216702392 1 2.357281238 3.666960405 9911 transmembrane and coiled-coil domain family 2 "GO:0005515,GO:0005783,GO:0005789,GO:0012505,GO:0016021,GO:0042982" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endomembrane system|integral component of membrane|amyloid precursor protein metabolic process TMCC3 596.2910829 586.6445497 605.9376162 1.032887149 0.046682636 0.909332675 1 4.991009052 5.377212024 57458 transmembrane and coiled-coil domain family 3 "GO:0005515,GO:0005783,GO:0005789,GO:0012505,GO:0016021,GO:0042802,GO:0071889" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endomembrane system|integral component of membrane|identical protein binding|14-3-3 protein binding TMCO1 1497.665755 1418.908444 1576.423066 1.111011125 0.151873263 0.64786731 1 15.38815997 17.83286123 54499 transmembrane and coiled-coil domains 1 "GO:0000139,GO:0005262,GO:0005737,GO:0005783,GO:0006874,GO:0006983,GO:0030176,GO:0032469,GO:0070588" Golgi membrane|calcium channel activity|cytoplasm|endoplasmic reticulum|cellular calcium ion homeostasis|ER overload response|integral component of endoplasmic reticulum membrane|endoplasmic reticulum calcium ion homeostasis|calcium ion transmembrane transport TMCO3 1103.152718 919.5501073 1286.755328 1.399331388 0.48473766 0.162235816 1 3.965596812 5.788220436 55002 transmembrane and coiled-coil domains 3 "GO:0015299,GO:0016021,GO:1902600" solute:proton antiporter activity|integral component of membrane|proton transmembrane transport TMCO4 335.1165866 278.0979353 392.1352378 1.410061665 0.495758256 0.278367338 1 2.362012302 3.474051007 255104 transmembrane and coiled-coil domains 4 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMCO6 322.6374778 266.9334197 378.341536 1.417362938 0.50320923 0.276811311 1 4.544281016 6.718343147 55374 transmembrane and coiled-coil domains 6 "GO:0005515,GO:0006606,GO:0016021,GO:0061608" protein binding|protein import into nucleus|integral component of membrane|nuclear import signal receptor activity TMED1 480.5334004 452.6703619 508.3964389 1.123105204 0.167493074 0.687843739 1 13.01143979 15.2426938 11018 transmembrane p24 trafficking protein 1 "GO:0005102,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005886,GO:0006886,GO:0006888,GO:0007030,GO:0007165,GO:0007267,GO:0016021,GO:0030134,GO:0033116" signaling receptor binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|signal transduction|cell-cell signaling|integral component of membrane|COPII-coated ER to Golgi transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane TMED10 6505.001483 6587.064235 6422.938731 0.975083664 -0.036402084 0.911509377 1 81.19045162 82.57769718 10972 transmembrane p24 trafficking protein 10 "GO:0000139,GO:0001822,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005801,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0008320,GO:0012507,GO:0016021,GO:0019905,GO:0030133,GO:0030134,GO:0030137,GO:0030140,GO:0030667,GO:0032612,GO:0033116,GO:0035459,GO:0035964,GO:0042470,GO:0042589,GO:0043279,GO:0044877,GO:0045055,GO:0048199,GO:0048205,GO:0048208,GO:0050714,GO:0070765,GO:0071806,GO:0106272,GO:0106273,GO:1902003,GO:1902960" "Golgi membrane|kidney development|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|protein transmembrane transporter activity|ER to Golgi transport vesicle membrane|integral component of membrane|syntaxin binding|transport vesicle|COPII-coated ER to Golgi transport vesicle|COPI-coated vesicle|trans-Golgi network transport vesicle|secretory granule membrane|interleukin-1 production|endoplasmic reticulum-Golgi intermediate compartment membrane|vesicle cargo loading|COPI-coated vesicle budding|melanosome|zymogen granule membrane|response to alkaloid|protein-containing complex binding|regulated exocytosis|vesicle targeting, to, from or within Golgi|COPI coating of Golgi vesicle|COPII vesicle coating|positive regulation of protein secretion|gamma-secretase complex|protein transmembrane transport|protein localization to ERGIC|cytosol to ERGIC protein transport|regulation of amyloid-beta formation|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" hsa05130 Pathogenic Escherichia coli infection TMED2 6156.6056 6041.017924 6272.193276 1.038267616 0.054178349 0.867942572 1 119.2811877 129.1805689 10959 transmembrane p24 trafficking protein 2 "GO:0000139,GO:0001843,GO:0001893,GO:0001947,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0010628,GO:0012507,GO:0016021,GO:0030133,GO:0030134,GO:0030137,GO:0030663,GO:0032525,GO:0032580,GO:0033116,GO:0034260,GO:0035264,GO:0035459,GO:0036342,GO:0036499,GO:0042589,GO:0043231,GO:0048205,GO:0048208,GO:0060716,GO:0072659,GO:0090158,GO:1903912,GO:2000638" "Golgi membrane|neural tube closure|maternal placenta development|heart looping|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|positive regulation of gene expression|ER to Golgi transport vesicle membrane|integral component of membrane|transport vesicle|COPII-coated ER to Golgi transport vesicle|COPI-coated vesicle|COPI-coated vesicle membrane|somite rostral/caudal axis specification|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|negative regulation of GTPase activity|multicellular organism growth|vesicle cargo loading|post-anal tail morphogenesis|PERK-mediated unfolded protein response|zymogen granule membrane|intracellular membrane-bounded organelle|COPI coating of Golgi vesicle|COPII vesicle coating|labyrinthine layer blood vessel development|protein localization to plasma membrane|endoplasmic reticulum membrane organization|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|regulation of SREBP signaling pathway" TMED3 3108.095297 3440.700733 2775.489861 0.806664129 -0.309959991 0.329954112 1 27.16859277 22.85997859 23423 transmembrane p24 trafficking protein 3 "GO:0000139,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0016021,GO:0030126,GO:0030133,GO:0030134,GO:0032580,GO:0033116" "Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|integral component of membrane|COPI vesicle coat|transport vesicle|COPII-coated ER to Golgi transport vesicle|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane" TMED4 2740.0686 2529.270273 2950.866928 1.166687071 0.222417653 0.485151764 1 34.50003141 41.98457926 222068 transmembrane p24 trafficking protein 4 "GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006886,GO:0006888,GO:0007030,GO:0016021,GO:0030134,GO:0043123" endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|integral component of membrane|COPII-coated ER to Golgi transport vesicle|positive regulation of I-kappaB kinase/NF-kappaB signaling TMED5 2041.261521 1804.591712 2277.931331 1.262297347 0.336051792 0.296499708 1 15.65539637 20.61302201 50999 transmembrane p24 trafficking protein 5 "GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005801,GO:0006886,GO:0006888,GO:0007030,GO:0016021,GO:0030134,GO:0033116,GO:0070971,GO:0090161" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|integral component of membrane|COPII-coated ER to Golgi transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|endoplasmic reticulum exit site|Golgi ribbon formation TMED7 1941.94677 1952.775283 1931.118256 0.988909617 -0.016089426 0.961978771 1 25.2427716 26.03811661 51014 transmembrane p24 trafficking protein 7 "GO:0000139,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0016021,GO:0030126,GO:0030127,GO:0030133,GO:0030134,GO:0033116" "Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|integral component of membrane|COPI vesicle coat|COPII vesicle coat|transport vesicle|COPII-coated ER to Golgi transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane" TMED8 1252.660285 1272.754784 1232.565785 0.968423612 -0.04628984 0.893872935 1 8.067652042 8.149452978 283578 transmembrane p24 trafficking protein family member 8 GO:0005515 protein binding TMED9 4896.494719 5336.638482 4456.350956 0.835048312 -0.260068427 0.417649254 1 106.1594315 92.46686133 54732 transmembrane p24 trafficking protein 9 "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0008021,GO:0010638,GO:0016021,GO:0019905,GO:0030133,GO:0030134,GO:0030140,GO:0032527,GO:0033116,GO:0034498,GO:0048205,GO:0070062" "Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|synaptic vesicle|positive regulation of organelle organization|integral component of membrane|syntaxin binding|transport vesicle|COPII-coated ER to Golgi transport vesicle|trans-Golgi network transport vesicle|protein exit from endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment membrane|early endosome to Golgi transport|COPI coating of Golgi vesicle|extracellular exosome" TMEFF1 49.02024521 50.74779842 47.29269199 0.931916132 -0.10172797 0.929627314 1 0.998134743 0.970246158 8577 transmembrane protein with EGF like and two follistatin like domains 1 "GO:0005102,GO:0005604,GO:0005886,GO:0008045,GO:0009887,GO:0009888,GO:0016021,GO:0016358" signaling receptor binding|basement membrane|plasma membrane|motor neuron axon guidance|animal organ morphogenesis|tissue development|integral component of membrane|dendrite development TMEFF2 34.81086165 22.3290313 47.29269199 2.117991208 1.082696601 0.255423883 1 0.133155147 0.29416977 23671 transmembrane protein with EGF like and two follistatin like domains 2 "GO:0003674,GO:0005515,GO:0005604,GO:0005886,GO:0009887,GO:0009888,GO:0016021,GO:0016477,GO:0030336,GO:0034446,GO:0044319,GO:0045720,GO:0051497" "molecular_function|protein binding|basement membrane|plasma membrane|animal organ morphogenesis|tissue development|integral component of membrane|cell migration|negative regulation of cell migration|substrate adhesion-dependent cell spreading|wound healing, spreading of cells|negative regulation of integrin biosynthetic process|negative regulation of stress fiber assembly" TMEM101 1007.502397 981.4624214 1033.542373 1.053063623 0.074592602 0.834502967 1 23.55810865 25.87682333 84336 transmembrane protein 101 "GO:0005515,GO:0005575,GO:0016021,GO:0043123" protein binding|cellular_component|integral component of membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling TMEM102 378.6975885 394.8178717 362.5773053 0.918340661 -0.12289867 0.784839622 1 9.357104524 8.963161556 284114 transmembrane protein 102 "GO:0005515,GO:0005739,GO:0005886,GO:0006915,GO:0007165,GO:0009986,GO:0010820,GO:0016021,GO:0032991,GO:0034097,GO:0042981,GO:0045785,GO:0050730,GO:1901028,GO:2000406" protein binding|mitochondrion|plasma membrane|apoptotic process|signal transduction|cell surface|positive regulation of T cell chemotaxis|integral component of membrane|protein-containing complex|response to cytokine|regulation of apoptotic process|positive regulation of cell adhesion|regulation of peptidyl-tyrosine phosphorylation|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of T cell migration TMEM104 731.9322031 732.7982092 731.0661971 0.997636441 -0.003413932 0.996903231 1 4.559415742 4.744576225 54868 transmembrane protein 104 "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane TMEM106A 179.7850238 132.9592319 226.6108158 1.704363154 0.769232768 0.168813624 1 2.048027993 3.640943629 113277 transmembrane protein 106A "GO:0003674,GO:0005515,GO:0005886,GO:0008150,GO:0016021,GO:0032611,GO:0032635,GO:0032640,GO:0035780,GO:0035781,GO:0042116,GO:0043123,GO:0043410,GO:0045087,GO:0045348,GO:1904407" molecular_function|protein binding|plasma membrane|biological_process|integral component of membrane|interleukin-1 beta production|interleukin-6 production|tumor necrosis factor production|CD80 biosynthetic process|CD86 biosynthetic process|macrophage activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|innate immune response|positive regulation of MHC class II biosynthetic process|positive regulation of nitric oxide metabolic process TMEM106B 1154.614351 1238.246281 1070.982421 0.864918746 -0.209363489 0.543650634 1 9.554053303 8.619436997 54664 transmembrane protein 106B "GO:0003674,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0007040,GO:0007041,GO:0016021,GO:0031902,GO:0032418,GO:0048813" molecular_function|protein binding|lysosome|lysosomal membrane|endosome|lysosome organization|lysosomal transport|integral component of membrane|late endosome membrane|lysosome localization|dendrite morphogenesis TMEM106C 3074.453785 2622.646222 3526.261347 1.344543277 0.427116192 0.179701903 1 81.53945919 114.355891 79022 transmembrane protein 106C "GO:0003674,GO:0005515,GO:0005575,GO:0005789,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|endoplasmic reticulum membrane|biological_process|integral component of membrane TMEM107 458.3313001 315.6513062 601.0112941 1.904035505 0.929060381 0.026904246 0.724502122 7.008603729 13.91946289 84314 transmembrane protein 107 "GO:0003127,GO:0003674,GO:0005515,GO:0010468,GO:0016021,GO:0021532,GO:0035869,GO:0036038,GO:0042733,GO:0060021,GO:0060271,GO:0097094,GO:1904491,GO:1905515" detection of nodal flow|molecular_function|protein binding|regulation of gene expression|integral component of membrane|neural tube patterning|ciliary transition zone|MKS complex|embryonic digit morphogenesis|roof of mouth development|cilium assembly|craniofacial suture morphogenesis|protein localization to ciliary transition zone|non-motile cilium assembly TMEM109 2873.887403 3056.032421 2691.742386 0.88079641 -0.183119506 0.565344073 1 72.69951201 66.79177137 79073 transmembrane protein 109 "GO:0003674,GO:0005244,GO:0005515,GO:0005640,GO:0016021,GO:0033017,GO:0034220,GO:0034765,GO:0042771,GO:0060548,GO:0070062,GO:0071480" molecular_function|voltage-gated ion channel activity|protein binding|nuclear outer membrane|integral component of membrane|sarcoplasmic reticulum membrane|ion transmembrane transport|regulation of ion transmembrane transport|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of cell death|extracellular exosome|cellular response to gamma radiation TMEM11 500.0281263 471.9545253 528.1017273 1.118967398 0.162168003 0.694371951 1 24.95076383 29.12173251 8834 transmembrane protein 11 "GO:0003674,GO:0005515,GO:0005739,GO:0005887,GO:0007005,GO:0007007,GO:0031305" molecular_function|protein binding|mitochondrion|integral component of plasma membrane|mitochondrion organization|inner mitochondrial membrane organization|integral component of mitochondrial inner membrane TMEM115 1254.205729 1176.333967 1332.077491 1.13239737 0.179380304 0.598432685 1 28.2758261 33.39874007 11070 transmembrane protein 115 "GO:0000139,GO:0003674,GO:0005515,GO:0005634,GO:0005794,GO:0006888,GO:0006890,GO:0008285,GO:0015031,GO:0016021,GO:0017119,GO:0032580,GO:0042802" "Golgi membrane|molecular_function|protein binding|nucleus|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|negative regulation of cell population proliferation|protein transport|integral component of membrane|Golgi transport complex|Golgi cisterna membrane|identical protein binding" TMEM116 155.1210003 164.4228669 145.8191336 0.886854343 -0.173230919 0.775706205 1 2.424996552 2.243258657 89894 transmembrane protein 116 "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane TMEM117 116.4460314 113.6750685 119.2169944 1.048752343 0.068674034 0.928838577 1 1.668282004 1.824980965 84216 transmembrane protein 117 "GO:0003674,GO:0005783,GO:0005886,GO:0016021,GO:0070059" molecular_function|endoplasmic reticulum|plasma membrane|integral component of membrane|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TMEM120A 553.3039121 510.5228521 596.084972 1.167597042 0.223542461 0.576626961 1 15.45497994 18.82250242 83862 transmembrane protein 120A "GO:0003674,GO:0005216,GO:0005515,GO:0005575,GO:0005637,GO:0005886,GO:0016020,GO:0016021,GO:0034220,GO:0045444,GO:0050966,GO:0051260,GO:0051291" molecular_function|ion channel activity|protein binding|cellular_component|nuclear inner membrane|plasma membrane|membrane|integral component of membrane|ion transmembrane transport|fat cell differentiation|detection of mechanical stimulus involved in sensory perception of pain|protein homooligomerization|protein heterooligomerization TMEM120B 195.5113981 231.4099608 159.6128355 0.689740558 -0.535874293 0.324552946 1 4.873221683 3.506048033 144404 transmembrane protein 120B "GO:0003674,GO:0005216,GO:0005515,GO:0005575,GO:0005637,GO:0008150,GO:0016020,GO:0016021,GO:0034220,GO:0045444,GO:0051291" molecular_function|ion channel activity|protein binding|cellular_component|nuclear inner membrane|biological_process|membrane|integral component of membrane|ion transmembrane transport|fat cell differentiation|protein heterooligomerization TMEM121 133.1064519 107.5853326 158.6275711 1.474434917 0.560162142 0.365176141 1 2.48464093 3.821247541 80757 transmembrane protein 121 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane TMEM121B 30.91434131 25.37389921 36.45478341 1.436704036 0.522762895 0.608580815 1 0.253771422 0.380299676 27439 transmembrane protein 121B TMEM123 6624.85264 6866.177126 6383.528155 0.929706303 -0.105153058 0.74751558 1 105.2504991 102.067122 114908 transmembrane protein 123 "GO:0005515,GO:0009897,GO:0016021,GO:0031410,GO:0038023,GO:0070267" protein binding|external side of plasma membrane|integral component of membrane|cytoplasmic vesicle|signaling receptor activity|oncosis TMEM126A 290.284334 311.5914823 268.9771857 0.863236645 -0.212171986 0.660908679 1 20.79184367 18.72142054 84233 transmembrane protein 126A "GO:0003674,GO:0005739,GO:0005743,GO:0016021,GO:0021554,GO:0032981" molecular_function|mitochondrion|mitochondrial inner membrane|integral component of membrane|optic nerve development|mitochondrial respiratory chain complex I assembly TMEM126B 453.524982 492.2536447 414.7963194 0.842647533 -0.246998795 0.557404885 1 18.87275589 16.58812144 55863 transmembrane protein 126B "GO:0003674,GO:0005515,GO:0005739,GO:0005743,GO:0016021,GO:0032981" molecular_function|protein binding|mitochondrion|mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex I assembly TMEM127 1547.494353 1625.959461 1469.029245 0.903484546 -0.146428171 0.658429184 1 12.92358925 12.17922922 55654 transmembrane protein 127 "GO:0003674,GO:0005737,GO:0005769,GO:0005886,GO:0007032,GO:0008285,GO:0016020,GO:0016021,GO:0031267,GO:0032006,GO:0032007" molecular_function|cytoplasm|early endosome|plasma membrane|endosome organization|negative regulation of cell population proliferation|membrane|integral component of membrane|small GTPase binding|regulation of TOR signaling|negative regulation of TOR signaling TMEM128 331.12827 308.5466144 353.7099255 1.146374353 0.197078239 0.671082102 1 8.939815521 10.68983368 85013 transmembrane protein 128 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane TMEM129 667.937275 702.3495301 633.5250198 0.902008178 -0.148787582 0.698905379 1 9.232163499 8.68620134 92305 "transmembrane protein 129, E3 ubiquitin ligase" "GO:0000209,GO:0005783,GO:0005789,GO:0006986,GO:0016021,GO:0016567,GO:0030433,GO:0030970,GO:0046872,GO:0061630" "protein polyubiquitination|endoplasmic reticulum|endoplasmic reticulum membrane|response to unfolded protein|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|metal ion binding|ubiquitin protein ligase activity" TMEM131 1163.226631 1254.485577 1071.967685 0.85450778 -0.226834468 0.509888004 1 9.440604593 8.414566733 23505 transmembrane protein 131 "GO:0003674,GO:0005575,GO:0008150,GO:0016020,GO:0016021" molecular_function|cellular_component|biological_process|membrane|integral component of membrane TMEM131L 282.5830896 290.277407 274.8887722 0.946986454 -0.078584306 0.877335779 1 2.371213972 2.342234867 23240 transmembrane 131 like "GO:0005737,GO:0005783,GO:0005886,GO:0016020,GO:0016021,GO:0016055,GO:0033088,GO:0090090" cytoplasm|endoplasmic reticulum|plasma membrane|membrane|integral component of membrane|Wnt signaling pathway|negative regulation of immature T cell proliferation in thymus|negative regulation of canonical Wnt signaling pathway TMEM132A 6629.644858 7597.960379 5661.329337 0.745111721 -0.424471337 0.193867175 1 71.36681922 55.46687086 54972 transmembrane protein 132A "GO:0000139,GO:0003674,GO:0005783,GO:0005788,GO:0005789,GO:0005794,GO:0008150,GO:0016021,GO:0043687,GO:0044267,GO:0070062" Golgi membrane|molecular_function|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi apparatus|biological_process|integral component of membrane|post-translational protein modification|cellular protein metabolic process|extracellular exosome TMEM134 338.2329617 322.7559979 353.7099255 1.095905042 0.132122797 0.776714747 1 3.620476784 4.138611134 80194 transmembrane protein 134 "GO:0005515,GO:0005829,GO:0016021,GO:0016032,GO:0048471" protein binding|cytosol|integral component of membrane|viral process|perinuclear region of cytoplasm TMEM135 289.2396865 307.5316584 270.9477146 0.881040072 -0.182720456 0.706986242 1 3.828759487 3.51859821 65084 transmembrane protein 135 "GO:0005777,GO:0005778,GO:0005811,GO:0007031,GO:0009409,GO:0016021,GO:0031966,GO:0032094,GO:0090140" peroxisome|peroxisomal membrane|lipid droplet|peroxisome organization|response to cold|integral component of membrane|mitochondrial membrane|response to food|regulation of mitochondrial fission TMEM138 381.8733468 443.5357582 320.2109354 0.721950665 -0.470027843 0.285162668 1 6.545315108 4.928945427 51524 transmembrane protein 138 "GO:0005774,GO:0005929,GO:0016021,GO:0060271" vacuolar membrane|cilium|integral component of membrane|cilium assembly TMEM139 33.49626856 33.49354696 33.49899016 1.000162515 0.000234441 1 1 0.779921837 0.813649915 135932 transmembrane protein 139 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM140 61.27666731 46.68797455 75.86536007 1.624944342 0.700390303 0.382015197 1 1.184066703 2.006922436 55281 transmembrane protein 140 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM141 363.9159006 428.3114187 299.5203826 0.699305154 -0.516005957 0.247249679 1 25.85513988 18.8594729 85014 transmembrane protein 141 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM143 49.52772319 51.76275439 47.29269199 0.913643266 -0.130297123 0.901385705 1 1.158462617 1.104014078 55260 transmembrane protein 143 "GO:0003674,GO:0005515,GO:0005739,GO:0008150,GO:0016021" molecular_function|protein binding|mitochondrion|biological_process|integral component of membrane TMEM144 87.51434313 122.8096722 52.21901408 0.42520278 -1.233777064 0.083627783 1 1.66484921 0.73839191 55314 transmembrane protein 144 "GO:0005515,GO:0015144,GO:0016021,GO:0034219" protein binding|carbohydrate transmembrane transporter activity|integral component of membrane|carbohydrate transmembrane transport TMEM145 70.33432054 93.37594909 47.29269199 0.506476159 -0.981433737 0.198492847 1 2.096259934 1.107439653 284339 transmembrane protein 145 "GO:0007186,GO:0016021,GO:0019236" G protein-coupled receptor signaling pathway|integral component of membrane|response to pheromone TMEM147 1241.1125 1190.543351 1291.68165 1.084951379 0.117630391 0.731074359 1 69.46638334 78.61418101 10430 transmembrane protein 147 "GO:0005515,GO:0005789,GO:0005886,GO:0016021,GO:0032991" protein binding|endoplasmic reticulum membrane|plasma membrane|integral component of membrane|protein-containing complex TMEM14A 278.941669 277.0829794 280.8003587 1.013416123 0.019226687 0.976547825 1 14.00526489 14.80454507 28978 transmembrane protein 14A "GO:0005515,GO:0005789,GO:0006839,GO:0006915,GO:0016021,GO:0031966,GO:0043066,GO:1901029" protein binding|endoplasmic reticulum membrane|mitochondrial transport|apoptotic process|integral component of membrane|mitochondrial membrane|negative regulation of apoptotic process|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway TMEM14B 1017.951594 988.5671132 1047.336075 1.059448631 0.083313638 0.814768188 1 28.36681973 31.3477578 81853 transmembrane protein 14B "GO:0005515,GO:0005743,GO:0006839,GO:0016021,GO:0021987,GO:0031966,GO:0042802,GO:0061351,GO:2000045" protein binding|mitochondrial inner membrane|mitochondrial transport|integral component of membrane|cerebral cortex development|mitochondrial membrane|identical protein binding|neural precursor cell proliferation|regulation of G1/S transition of mitotic cell cycle TMEM14C 1372.432016 1243.321061 1501.542971 1.207687232 0.272246872 0.417265873 1 61.13575299 77.01328882 51522 transmembrane protein 14C "GO:0005515,GO:0005743,GO:0006783,GO:0006839,GO:0016021,GO:0030218,GO:0031966,GO:0070453" protein binding|mitochondrial inner membrane|heme biosynthetic process|mitochondrial transport|integral component of membrane|erythrocyte differentiation|mitochondrial membrane|regulation of heme biosynthetic process TMEM150A 186.0947247 193.85659 178.3328594 0.919921574 -0.120417222 0.835620129 1 3.946202732 3.786571194 129303 transmembrane protein 150A "GO:0005515,GO:0005764,GO:0005887,GO:0009056,GO:0010506,GO:0046854,GO:0072659" protein binding|lysosome|integral component of plasma membrane|catabolic process|regulation of autophagy|phosphatidylinositol phosphorylation|protein localization to plasma membrane TMEM154 119.3572874 110.6302006 128.0843742 1.157770424 0.211349207 0.75012602 1 0.437019685 0.527763535 201799 transmembrane protein 154 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM156 199.7169582 283.1727152 116.2612012 0.410566396 -1.284312544 0.018402002 0.586872333 1.964616308 0.841350728 80008 transmembrane protein 156 GO:0016021 integral component of membrane TMEM158 656.0235435 898.236032 413.8110549 0.460693003 -1.118122409 0.003821426 0.223256938 24.96843372 11.99827594 25907 transmembrane protein 158 "GO:0016021,GO:0042277" integral component of membrane|peptide binding TMEM159 766.6770007 649.5718198 883.7821816 1.360561149 0.444201799 0.230796018 1 11.55956469 16.40497131 57146 transmembrane protein 159 "GO:0005515,GO:0005789,GO:0005811,GO:0016021,GO:0140042" protein binding|endoplasmic reticulum membrane|lipid droplet|integral component of membrane|lipid droplet formation TMEM160 252.0574601 257.798816 246.3161041 0.955458632 -0.065734683 0.903190179 1 19.93374133 19.86628386 54958 transmembrane protein 160 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM161A 515.3333757 608.973581 421.6931703 0.692465459 -0.530185985 0.19126138 1 11.86701175 8.57147213 54929 transmembrane protein 161A "GO:0005515,GO:0016021,GO:0032526,GO:0034599,GO:0034644,GO:0045739,GO:1902230" protein binding|integral component of membrane|response to retinoic acid|cellular response to oxidative stress|cellular response to UV|positive regulation of DNA repair|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage TMEM161B 582.5176701 520.6724118 644.3629284 1.23755919 0.307497529 0.435568595 1 1.676961579 2.164736411 153396 transmembrane protein 161B GO:0016021 integral component of membrane TMEM163 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.04953403 0.012539066 81615 transmembrane protein 163 "GO:0008270,GO:0016020,GO:0030285,GO:0031901,GO:0099180" zinc ion binding|membrane|integral component of synaptic vesicle membrane|early endosome membrane|zinc ion import into synaptic vesicle TMEM164 678.591591 757.1571524 600.0260297 0.792472247 -0.335567684 0.377942979 1 2.738704376 2.263836966 84187 transmembrane protein 164 GO:0016021 integral component of membrane TMEM165 1536.780654 1567.092015 1506.469293 0.961315148 -0.056918627 0.865019843 1 23.69891974 23.76349233 55858 transmembrane protein 165 "GO:0005384,GO:0005765,GO:0005794,GO:0006487,GO:0006874,GO:0010008,GO:0015085,GO:0016021,GO:0031901,GO:0031902,GO:0032468,GO:0032472,GO:0032588,GO:0035751,GO:0043231,GO:0046873,GO:0070588,GO:0071421" manganese ion transmembrane transporter activity|lysosomal membrane|Golgi apparatus|protein N-linked glycosylation|cellular calcium ion homeostasis|endosome membrane|calcium ion transmembrane transporter activity|integral component of membrane|early endosome membrane|late endosome membrane|Golgi calcium ion homeostasis|Golgi calcium ion transport|trans-Golgi network membrane|regulation of lysosomal lumen pH|intracellular membrane-bounded organelle|metal ion transmembrane transporter activity|calcium ion transmembrane transport|manganese ion transmembrane transport TMEM167A 1597.023314 1846.204906 1347.841722 0.730060741 -0.453911594 0.167997516 1 20.65012489 15.72525176 153339 transmembrane protein 167A "GO:0000139,GO:0005515,GO:0005794,GO:0009306,GO:0016021,GO:0045054,GO:0046907" Golgi membrane|protein binding|Golgi apparatus|protein secretion|integral component of membrane|constitutive secretory pathway|intracellular transport TMEM167B 829.0225639 769.336624 888.7085037 1.155162092 0.208095304 0.56956183 1 14.07157311 16.95514506 56900 transmembrane protein 167B "GO:0000139,GO:0003674,GO:0005515,GO:0005794,GO:0016021,GO:0045054" Golgi membrane|molecular_function|protein binding|Golgi apparatus|integral component of membrane|constitutive secretory pathway TMEM168 622.9120273 722.6486495 523.1754052 0.723969256 -0.465999661 0.229405507 1 3.197868479 2.414886101 64418 transmembrane protein 168 "GO:0016021,GO:0030133" integral component of membrane|transport vesicle TMEM169 10.49373413 10.14955968 10.83790858 1.067820568 0.094669242 1 1 0.134530069 0.149842005 92691 transmembrane protein 169 GO:0016021 integral component of membrane TMEM17 60.57347264 65.97213794 55.17480733 0.83633499 -0.257847172 0.761585839 1 0.687359813 0.599625832 200728 transmembrane protein 17 "GO:0005515,GO:0007224,GO:0016021,GO:0035869,GO:0036038,GO:0060170,GO:0060271,GO:1905515" protein binding|smoothened signaling pathway|integral component of membrane|ciliary transition zone|MKS complex|ciliary membrane|cilium assembly|non-motile cilium assembly TMEM170A 453.3846891 381.6234441 525.145934 1.376084049 0.46056859 0.27203022 1 3.280360006 4.708498092 124491 transmembrane protein 170A "GO:0005515,GO:0005635,GO:0005789,GO:0006998,GO:0016021,GO:0051292,GO:0071786" protein binding|nuclear envelope|endoplasmic reticulum membrane|nuclear envelope organization|integral component of membrane|nuclear pore complex assembly|endoplasmic reticulum tubular network organization TMEM170B 129.7146879 145.1387035 114.2906723 0.78745827 -0.344724623 0.584344036 1 0.826764516 0.679086828 100113407 transmembrane protein 170B "GO:0005515,GO:0005886,GO:0016021,GO:0016055,GO:0090090" protein binding|plasma membrane|integral component of membrane|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway TMEM171 17.09094793 23.34398727 10.83790858 0.464269812 -1.106964619 0.35175282 1 0.946589754 0.458403764 134285 transmembrane protein 171 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM175 159.628919 169.4976467 149.7601913 0.883553219 -0.17861106 0.766150057 1 3.493877841 3.220003616 84286 transmembrane protein 175 "GO:0005267,GO:0005764,GO:0005765,GO:0005768,GO:0010008,GO:0016021,GO:0022841,GO:0035751,GO:0071805,GO:0090385" potassium channel activity|lysosome|lysosomal membrane|endosome|endosome membrane|integral component of membrane|potassium ion leak channel activity|regulation of lysosomal lumen pH|potassium ion transmembrane transport|phagosome-lysosome fusion TMEM177 132.7298643 149.1985274 116.2612012 0.779238262 -0.359863577 0.564339317 1 5.759435266 4.681295974 80775 transmembrane protein 177 "GO:0005515,GO:0031305" protein binding|integral component of mitochondrial inner membrane TMEM178B 621.4165633 755.1272405 487.7058862 0.645859214 -0.630708377 0.104244351 1 2.784052617 1.875561151 100507421 transmembrane protein 178B "GO:0016020,GO:0016021" membrane|integral component of membrane TMEM179B 730.1789177 815.0096426 645.3481928 0.791828905 -0.336739362 0.36869704 1 41.23612709 34.05847126 374395 transmembrane protein 179B "GO:0005515,GO:0005730,GO:0005886,GO:0016021,GO:0016607,GO:0030667,GO:0035577,GO:0043312,GO:0101003" protein binding|nucleolus|plasma membrane|integral component of membrane|nuclear speck|secretory granule membrane|azurophil granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane TMEM18 637.5628248 646.5269519 628.5986978 0.972269905 -0.04057123 0.920297714 1 4.816047845 4.884201419 129787 transmembrane protein 18 "GO:0003677,GO:0005737,GO:0016021,GO:0016477,GO:0031965" DNA binding|cytoplasm|integral component of membrane|cell migration|nuclear membrane TMEM181 1178.788464 1173.289099 1184.287829 1.00937427 0.013461217 0.971411047 1 6.089041272 6.410871583 57583 transmembrane protein 181 "GO:0009405,GO:0015643,GO:0016021" pathogenesis|toxic substance binding|integral component of membrane TMEM182 51.48340625 50.74779842 52.21901408 1.028990729 0.041229984 0.986980443 1 0.52485133 0.563331055 130827 transmembrane protein 182 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM183A 966.8541779 964.20817 969.5001859 1.005488458 0.007896521 0.985511237 1 15.38555207 16.13637967 92703 transmembrane protein 183A "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM184A 42.19762317 55.82257826 28.57266808 0.511847875 -0.966213 0.281792511 1 0.426878553 0.22790884 202915 transmembrane protein 184A "GO:0005215,GO:0005768,GO:0005886,GO:0006810,GO:0008201,GO:0016021,GO:0030658,GO:0030659,GO:0030667,GO:0031901,GO:0048471" transporter activity|endosome|plasma membrane|transport|heparin binding|integral component of membrane|transport vesicle membrane|cytoplasmic vesicle membrane|secretory granule membrane|early endosome membrane|perinuclear region of cytoplasm TMEM184B 4559.818334 4413.02855 4706.608118 1.066525644 0.092918655 0.771866384 1 56.77021281 63.15500217 25829 transmembrane protein 184B "GO:0005215,GO:0006810,GO:0016021" transporter activity|transport|integral component of membrane TMEM184C 530.7534319 619.1231407 442.383723 0.71453269 -0.484928079 0.228553206 1 7.530356134 5.612463738 55751 transmembrane protein 184C "GO:0005215,GO:0006810,GO:0016021" transporter activity|transport|integral component of membrane TMEM185A 409.9236911 441.5058462 378.341536 0.856934374 -0.222743371 0.607530162 1 7.451087495 6.660136909 84548 transmembrane protein 185A "GO:0005515,GO:0016021,GO:0030425" protein binding|integral component of membrane|dendrite TMEM185B 822.2605627 946.9539185 697.5672069 0.736643245 -0.440962002 0.227605765 1 8.098594279 6.222756147 79134 transmembrane protein 185B GO:0016021 integral component of membrane TMEM186 159.0323664 162.3929549 155.6717778 0.958611646 -0.060981628 0.927510998 1 5.715517915 5.714973499 25880 transmembrane protein 186 "GO:0005515,GO:0005739,GO:0016021" protein binding|mitochondrion|integral component of membrane TMEM187 223.9653 223.290313 224.640287 1.006045824 0.008696019 0.996494957 1 6.324869482 6.637205439 8269 transmembrane protein 187 "GO:0003674,GO:0005515,GO:0008150,GO:0016021,GO:0030133" molecular_function|protein binding|biological_process|integral component of membrane|transport vesicle TMEM19 679.9885778 650.5867757 709.3903799 1.090385489 0.124838268 0.745200839 1 5.819485175 6.618819829 55266 transmembrane protein 19 "GO:0005515,GO:0016020,GO:0016021" protein binding|membrane|integral component of membrane TMEM190 3.47811701 2.029911937 4.926322083 2.426864926 1.279093814 0.644064692 1 0.078779984 0.199423999 147744 transmembrane protein 190 "GO:0002079,GO:0002244,GO:0005515,GO:0005634,GO:0016021,GO:0043621" inner acrosomal membrane|hematopoietic progenitor cell differentiation|protein binding|nucleus|integral component of membrane|protein self-association TMEM191B 11.49384433 11.16451565 11.823173 1.058995604 0.082696601 1 1 0.404176792 0.446458874 728229 transmembrane protein 191B GO:0016021 integral component of membrane TMEM191C 5.508028946 6.08973581 4.926322083 0.808954975 -0.305868687 0.976518791 1 0.281408427 0.237452845 645426 transmembrane protein 191C GO:0016021 integral component of membrane TMEM192 539.9407377 539.9565752 539.9249003 0.999941338 -8.46E-05 1 1 2.738523501 2.85632042 201931 transmembrane protein 192 "GO:0005634,GO:0005654,GO:0005764,GO:0005765,GO:0005768,GO:0005770,GO:0005783,GO:0005794,GO:0005886,GO:0016021,GO:0042803,GO:0048471" nucleus|nucleoplasm|lysosome|lysosomal membrane|endosome|late endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of membrane|protein homodimerization activity|perinuclear region of cytoplasm TMEM198 58.27633673 43.64310664 72.90956682 1.670586089 0.74035433 0.362897644 1 0.862751517 1.503386071 130612 transmembrane protein 198 "GO:0005886,GO:0007275,GO:0016021,GO:0016055,GO:0031410,GO:0090263" plasma membrane|multicellular organism development|integral component of membrane|Wnt signaling pathway|cytoplasmic vesicle|positive regulation of canonical Wnt signaling pathway TMEM199 580.1799562 630.2876564 530.0722561 0.841000535 -0.249821377 0.52741771 1 10.35751015 9.085891977 147007 transmembrane protein 199 "GO:0005515,GO:0005764,GO:0005783,GO:0005789,GO:0006879,GO:0007042,GO:0012505,GO:0016021,GO:0016471,GO:0030663,GO:0033116,GO:0036295,GO:0070072,GO:1905146" protein binding|lysosome|endoplasmic reticulum|endoplasmic reticulum membrane|cellular iron ion homeostasis|lysosomal lumen acidification|endomembrane system|integral component of membrane|vacuolar proton-transporting V-type ATPase complex|COPI-coated vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|cellular response to increased oxygen levels|vacuolar proton-transporting V-type ATPase complex assembly|lysosomal protein catabolic process TMEM200B 465.3860114 393.8029157 536.969107 1.363547819 0.447365296 0.282734968 1 7.16148238 10.1856613 399474 transmembrane protein 200B GO:0016021 integral component of membrane TMEM201 525.4020255 522.7023237 528.1017273 1.010329787 0.014826287 0.975932322 1 6.150796634 6.482021317 199953 transmembrane protein 201 "GO:0000922,GO:0005521,GO:0005639,GO:0005737,GO:0010761,GO:0030473,GO:0031965,GO:0051015" spindle pole|lamin binding|integral component of nuclear inner membrane|cytoplasm|fibroblast migration|nuclear migration along microtubule|nuclear membrane|actin filament binding TMEM203 958.6899928 944.9240066 972.4559791 1.029136706 0.041434636 0.909977589 1 30.54056633 32.78431275 94107 transmembrane protein 203 "GO:0005515,GO:0005783,GO:0005789,GO:0006874,GO:0007283,GO:0016021" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cellular calcium ion homeostasis|spermatogenesis|integral component of membrane TMEM205 1231.085666 1313.353023 1148.81831 0.87472164 -0.19310411 0.571673513 1 41.08505089 37.48604563 374882 transmembrane protein 205 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane TMEM208 407.7156299 425.2665507 390.164709 0.917459199 -0.124284095 0.777495231 1 24.11898157 23.08137383 29100 transmembrane protein 208 "GO:0005515,GO:0005773,GO:0005789,GO:0006624,GO:0006914,GO:0016021,GO:0043231" protein binding|vacuole|endoplasmic reticulum membrane|vacuolar protein processing|autophagy|integral component of membrane|intracellular membrane-bounded organelle TMEM209 1031.449618 1136.750685 926.1485516 0.814733225 -0.295600352 0.399370562 1 14.91126961 12.6720238 84928 transmembrane protein 209 GO:0016021 integral component of membrane TMEM214 1731.08138 1816.771183 1645.391576 0.905668028 -0.142945766 0.662101062 1 28.79907707 27.20592751 54867 transmembrane protein 214 "GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005881,GO:0006915,GO:0016021" endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|cytoplasmic microtubule|apoptotic process|integral component of membrane TMEM216 287.8535861 280.1278473 295.579325 1.055158664 0.077459952 0.878369094 1 13.35921585 14.70329483 51259 transmembrane protein 216 "GO:0005515,GO:0005829,GO:0005856,GO:0005929,GO:0016021,GO:0035869,GO:0036038,GO:0060271,GO:0097711,GO:1905515" protein binding|cytosol|cytoskeleton|cilium|integral component of membrane|ciliary transition zone|MKS complex|cilium assembly|ciliary basal body-plasma membrane docking|non-motile cilium assembly TMEM217 14.4941749 14.20938356 14.77896625 1.040084968 0.056701392 1 1 0.172910896 0.187588889 221468 transmembrane protein 217 GO:0016021 integral component of membrane TMEM218 253.8322722 278.0979353 229.5666091 0.825488362 -0.27668022 0.582348833 1 3.07391518 2.646785605 219854 transmembrane protein 218 "GO:0005515,GO:0005929,GO:0016021" protein binding|cilium|integral component of membrane TMEM219 974.7066017 962.178258 987.2349454 1.026041627 0.037089263 0.919452823 1 46.5878914 49.86019411 124446 transmembrane protein 219 "GO:0005515,GO:0005886,GO:0006915,GO:0016021,GO:0042981" protein binding|plasma membrane|apoptotic process|integral component of membrane|regulation of apoptotic process TMEM221 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.050619339 0.076882812 100130519 transmembrane protein 221 GO:0016021 integral component of membrane TMEM222 712.3874967 777.4562718 647.3187217 0.8326111 -0.264285303 0.483316034 1 24.6713142 21.42645931 84065 transmembrane protein 222 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM223 300.4514611 299.4120107 301.4909115 1.006943278 0.009982417 0.991156866 1 11.91214617 12.51154524 79064 transmembrane protein 223 "GO:0007399,GO:0016021" nervous system development|integral component of membrane TMEM225B 18.913019 13.19442759 24.63161041 1.866819174 0.90058219 0.438194642 1 0.083479227 0.162553603 100289187 transmembrane protein 225B "GO:0005515,GO:0010923,GO:0016021" protein binding|negative regulation of phosphatase activity|integral component of membrane TMEM229B 175.6009905 183.7070303 167.4949508 0.911750359 -0.133289232 0.821083394 1 2.086591838 1.984400724 161145 transmembrane protein 229B "GO:0005515,GO:0009617,GO:0016021" protein binding|response to bacterium|integral component of membrane TMEM230 3605.53234 3466.074632 3744.990047 1.080470112 0.111659165 0.726123603 1 62.33822888 70.25595588 29058 transmembrane protein 230 "GO:0005769,GO:0005770,GO:0005776,GO:0005783,GO:0005802,GO:0008021,GO:0016021,GO:0048489,GO:0055037" early endosome|late endosome|autophagosome|endoplasmic reticulum|trans-Golgi network|synaptic vesicle|integral component of membrane|synaptic vesicle transport|recycling endosome TMEM231 234.8329001 225.320225 244.3455753 1.08443694 0.116946163 0.826213924 1 2.606595366 2.948450571 79583 transmembrane protein 231 "GO:0001701,GO:0001944,GO:0005515,GO:0007224,GO:0016021,GO:0032880,GO:0035869,GO:0036038,GO:0042733,GO:0043010,GO:0060170,GO:0060271,GO:0060563" in utero embryonic development|vasculature development|protein binding|smoothened signaling pathway|integral component of membrane|regulation of protein localization|ciliary transition zone|MKS complex|embryonic digit morphogenesis|camera-type eye development|ciliary membrane|cilium assembly|neuroepithelial cell differentiation TMEM232 16.62800727 25.37389921 7.882115332 0.310638711 -1.686690471 0.160198251 1 0.070505211 0.022845082 642987 transmembrane protein 232 GO:0016021 integral component of membrane TMEM234 126.2986756 113.6750685 138.9222827 1.222099838 0.289362149 0.651258397 1 1.266719735 1.614742042 56063 transmembrane protein 234 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM237 547.3774798 509.5078961 585.2470634 1.148651607 0.199941286 0.618908458 1 4.725284289 5.661508925 65062 transmembrane protein 237 "GO:0005515,GO:0016020,GO:0016021,GO:0030111,GO:0032391,GO:0035869,GO:0060271,GO:0120199,GO:0120200" protein binding|membrane|integral component of membrane|regulation of Wnt signaling pathway|photoreceptor connecting cilium|ciliary transition zone|cilium assembly|cone photoreceptor outer segment|rod photoreceptor outer segment TMEM238 11.98647653 11.16451565 12.80843742 1.147245238 0.198173818 0.947374756 1 0.813587528 0.973590832 388564 transmembrane protein 238 GO:0016021 integral component of membrane TMEM240 34.94447363 31.46363502 38.42531225 1.22126106 0.288371627 0.783166237 1 1.153890019 1.469903609 339453 transmembrane protein 240 "GO:0016021,GO:0097060" integral component of membrane|synaptic membrane TMEM241 340.2304605 358.2794568 322.1814642 0.899246267 -0.153211829 0.74062649 1 2.254110628 2.114315532 85019 transmembrane protein 241 "GO:0005515,GO:0005794,GO:0015297,GO:0016021,GO:0055085" protein binding|Golgi apparatus|antiporter activity|integral component of membrane|transmembrane transport TMEM242 218.4748384 184.7219862 252.2276906 1.365444882 0.449371079 0.392308424 1 2.16462678 3.082997202 729515 transmembrane protein 242 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM243 379.4331963 344.0700733 414.7963194 1.20555768 0.269700679 0.542248987 1 8.048930903 10.12143576 79161 transmembrane protein 243 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM245 3971.971031 3527.986946 4415.955115 1.251692589 0.323880285 0.309648379 1 22.34339037 29.1717635 23731 transmembrane protein 245 "GO:0003674,GO:0008150,GO:0016021" molecular_function|biological_process|integral component of membrane TMEM248 1868.670018 2062.390528 1674.949508 0.812139838 -0.300199937 0.354223852 1 21.12718539 17.89733582 55069 transmembrane protein 248 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM249 35.61525515 43.64310664 27.58740366 0.632113655 -0.661744114 0.489262289 1 2.228194947 1.469143734 340393 transmembrane protein 249 GO:0016021 integral component of membrane TMEM25 804.2424957 759.1870643 849.2979271 1.118693886 0.161815318 0.66101495 1 9.836312755 11.477823 84866 transmembrane protein 25 "GO:0005515,GO:0005576,GO:0005764,GO:0005770,GO:0005886,GO:0016021,GO:0031647,GO:0090394" protein binding|extracellular region|lysosome|late endosome|plasma membrane|integral component of membrane|regulation of protein stability|negative regulation of excitatory postsynaptic potential TMEM250 1529.979559 1674.677348 1385.28177 0.827193233 -0.273703711 0.408130142 1 24.88747059 21.47354084 90120 transmembrane protein 250 "GO:0003924,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005940,GO:0008284,GO:0015630,GO:0016021,GO:0016032,GO:0031105,GO:0032153,GO:0034613,GO:0048524,GO:0060090,GO:0060271,GO:0061640" GTPase activity|protein binding|nucleus|nucleoplasm|cytoplasm|septin ring|positive regulation of cell population proliferation|microtubule cytoskeleton|integral component of membrane|viral process|septin complex|cell division site|cellular protein localization|positive regulation of viral process|molecular adaptor activity|cilium assembly|cytoskeleton-dependent cytokinesis TMEM251 217.5435139 255.768904 179.3181238 0.701094312 -0.512319565 0.329471295 1 5.326395021 3.895163978 26175 transmembrane protein 251 GO:0016021 integral component of membrane TMEM253 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.062307805 0.105150836 643382 transmembrane protein 253 GO:0016021 integral component of membrane TMEM254 437.6595525 451.6554059 423.6636991 0.938024196 -0.092302958 0.831847108 1 6.767678392 6.621702779 80195 transmembrane protein 254 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM255A 307.3713226 199.9463258 414.7963194 2.074538343 1.052790322 0.02580999 0.714976983 2.390598686 5.173018985 55026 transmembrane protein 255A GO:0016021 integral component of membrane TMEM255B 17.56873436 22.3290313 12.80843742 0.573622619 -0.801826182 0.504377076 1 0.253618897 0.151748291 348013 transmembrane protein 255B "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM256 701.1851247 853.5779694 548.79228 0.642931636 -0.637262754 0.091837193 1 96.92984957 65.00372799 254863 transmembrane protein 256 "GO:0003674,GO:0008150,GO:0016021,GO:0070062" molecular_function|biological_process|integral component of membrane|extracellular exosome TMEM258 1384.348223 1384.399941 1384.296505 0.999925285 -0.000107795 1 1 121.3061819 126.5221064 746 transmembrane protein 258 "GO:0005515,GO:0005783,GO:0006487,GO:0016021,GO:0032991,GO:0034998,GO:0043227" protein binding|endoplasmic reticulum|protein N-linked glycosylation|integral component of membrane|protein-containing complex|oligosaccharyltransferase I complex|membrane-bounded organelle TMEM259 2430.162609 2290.755621 2569.569598 1.121712668 0.16570317 0.604200748 1 41.52422723 48.58465388 91304 transmembrane protein 259 "GO:0005783,GO:0005789,GO:0016021,GO:0034976,GO:1901215,GO:1904294" endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|response to endoplasmic reticulum stress|negative regulation of neuron death|positive regulation of ERAD pathway TMEM260 340.3168136 397.8627396 282.7708875 0.710724728 -0.492637199 0.279050394 1 3.955701646 2.932519333 54916 transmembrane protein 260 GO:0016021 integral component of membrane TMEM263 1820.865889 1926.386428 1715.345349 0.890447173 -0.167398071 0.60677234 1 25.94805231 24.10065546 90488 transmembrane protein 263 GO:0016021 integral component of membrane TMEM265 73.54521359 77.1366536 69.95377357 0.906881104 -0.141014675 0.86742488 1 2.369132434 2.241071027 100862671 transmembrane protein 265 GO:0016021 integral component of membrane TMEM267 223.9031953 252.7240361 195.0823545 0.771918483 -0.373479593 0.474379915 1 2.671588577 2.151081906 64417 transmembrane protein 267 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM268 432.3769318 427.2964627 437.4574009 1.023779598 0.033905162 0.942053861 1 3.882500614 4.146044257 203197 transmembrane protein 268 "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane TMEM269 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.030202079 0.061162942 100129924 transmembrane protein 269 GO:0016021 integral component of membrane TMEM270 11.075441 16.23929549 5.911586499 0.364029739 -1.457871781 0.291645288 1 0.731078247 0.277598206 135886 transmembrane protein 270 GO:0016021 integral component of membrane TMEM30A 3035.123872 3099.675527 2970.572216 0.958349411 -0.061376341 0.847847048 1 35.53364202 35.52053782 55754 transmembrane protein 30A "GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0006855,GO:0010976,GO:0015247,GO:0015917,GO:0016020,GO:0016021,GO:0016324,GO:0030658,GO:0035577,GO:0035579,GO:0036010,GO:0043312,GO:0045332,GO:0061092,GO:0070863,GO:0140331,GO:1990531" protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|drug transmembrane transport|positive regulation of neuron projection development|aminophospholipid flippase activity|aminophospholipid transport|membrane|integral component of membrane|apical plasma membrane|transport vesicle membrane|azurophil granule membrane|specific granule membrane|protein localization to endosome|neutrophil degranulation|phospholipid translocation|positive regulation of phospholipid translocation|positive regulation of protein exit from endoplasmic reticulum|aminophospholipid translocation|phospholipid-translocating ATPase complex TMEM33 1018.349708 1049.464471 987.2349454 0.940703542 -0.088187958 0.803942472 1 6.998245317 6.866854909 55161 transmembrane protein 33 "GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0030176,GO:0034976,GO:0042470,GO:0061024,GO:0071786,GO:1903371,GO:1903896,GO:1903899" protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of endoplasmic reticulum membrane|response to endoplasmic reticulum stress|melanosome|membrane organization|endoplasmic reticulum tubular network organization|regulation of endoplasmic reticulum tubular network organization|positive regulation of IRE1-mediated unfolded protein response|positive regulation of PERK-mediated unfolded protein response TMEM35B 242.7325829 192.841634 292.6235317 1.517429228 0.601629231 0.235056008 1 10.55864698 16.71216229 100506144 transmembrane protein 35B GO:0016021 integral component of membrane TMEM37 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.111942376 0.068009142 140738 transmembrane protein 37 "GO:0005244,GO:0005262,GO:0016021,GO:0034765,GO:0070588" voltage-gated ion channel activity|calcium channel activity|integral component of membrane|regulation of ion transmembrane transport|calcium ion transmembrane transport TMEM38A 73.12681026 82.21143344 64.04218708 0.77899368 -0.360316471 0.640734893 1 1.582561414 1.285909594 79041 transmembrane protein 38A "GO:0005267,GO:0007029,GO:0010881,GO:0014808,GO:0016021,GO:0031965,GO:0033017,GO:0042802,GO:0070062,GO:0071313,GO:0071805" potassium channel activity|endoplasmic reticulum organization|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|integral component of membrane|nuclear membrane|sarcoplasmic reticulum membrane|identical protein binding|extracellular exosome|cellular response to caffeine|potassium ion transmembrane transport TMEM38B 322.8453187 281.1428032 364.5478341 1.296664293 0.374805013 0.418623318 1 3.918241929 5.299497956 55151 transmembrane protein 38B "GO:0005267,GO:0005515,GO:0005634,GO:0007029,GO:0008654,GO:0010881,GO:0014808,GO:0016021,GO:0030282,GO:0031965,GO:0033017,GO:0048286,GO:0060348,GO:0060487,GO:0061033,GO:0070278,GO:0071313,GO:0071805" potassium channel activity|protein binding|nucleus|endoplasmic reticulum organization|phospholipid biosynthetic process|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|integral component of membrane|bone mineralization|nuclear membrane|sarcoplasmic reticulum membrane|lung alveolus development|bone development|lung epithelial cell differentiation|secretion by lung epithelial cell involved in lung growth|extracellular matrix constituent secretion|cellular response to caffeine|potassium ion transmembrane transport TMEM39A 1301.268808 1430.072959 1172.464656 0.819863524 -0.286544319 0.39672292 1 13.07131391 11.17832518 55254 transmembrane protein 39A "GO:0005515,GO:0005789,GO:0006914,GO:0016020,GO:0016021,GO:0045070,GO:1901097,GO:1902902" protein binding|endoplasmic reticulum membrane|autophagy|membrane|integral component of membrane|positive regulation of viral genome replication|negative regulation of autophagosome maturation|negative regulation of autophagosome assembly TMEM39B 469.2892127 492.2536447 446.3247807 0.906696752 -0.141307978 0.737092135 1 5.870240296 5.55180072 55116 transmembrane protein 39B "GO:0005789,GO:0016020,GO:0016021,GO:0045070,GO:1901097,GO:1902902" endoplasmic reticulum membrane|membrane|integral component of membrane|positive regulation of viral genome replication|negative regulation of autophagosome maturation|negative regulation of autophagosome assembly TMEM40 99.02847643 68.00204988 130.054903 1.912514449 0.935470648 0.170237039 1 1.357534068 2.708141746 55287 transmembrane protein 40 GO:0016021 integral component of membrane TMEM41A 682.7404896 771.366536 594.1144432 0.77021029 -0.376675698 0.321495946 1 13.92762703 11.18928599 90407 transmembrane protein 41A "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM41B 791.9591037 727.7234293 856.194778 1.176538701 0.234548777 0.52502853 1 9.304878677 11.41912592 440026 transmembrane protein 41B "GO:0000045,GO:0005515,GO:0005789,GO:0007399,GO:0016021,GO:0044233" autophagosome assembly|protein binding|endoplasmic reticulum membrane|nervous system development|integral component of membrane|mitochondria-associated endoplasmic reticulum membrane TMEM42 369.6669052 383.653356 355.6804544 0.927088083 -0.109221679 0.810486014 1 19.8881157 19.23227083 131616 transmembrane protein 42 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM43 3538.993341 3329.055576 3748.931105 1.126124518 0.171366358 0.590400972 1 48.07668113 56.47247517 79188 transmembrane protein 43 "GO:0005515,GO:0005639,GO:0005783,GO:0005794,GO:0042802,GO:0071763" protein binding|integral component of nuclear inner membrane|endoplasmic reticulum|Golgi apparatus|identical protein binding|nuclear membrane organization TMEM44 1125.639609 1042.35978 1208.919439 1.15979095 0.213864786 0.536678136 1 19.17611537 23.19830635 93109 transmembrane protein 44 GO:0016021 integral component of membrane TMEM45A 162.3241693 252.7240361 71.92430241 0.284596208 -1.813011654 0.002226982 0.152172743 6.057539457 1.798213654 55076 transmembrane protein 45A "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM47 8.060264643 12.17947162 3.941057666 0.32358199 -1.627796782 0.302513 1 0.152684968 0.051534321 83604 transmembrane protein 47 "GO:0003674,GO:0005515,GO:0005886,GO:0005911,GO:0005912,GO:0008150,GO:0016021,GO:0098609" molecular_function|protein binding|plasma membrane|cell-cell junction|adherens junction|biological_process|integral component of membrane|cell-cell adhesion TMEM50A 2074.157032 2066.450352 2081.863712 1.007458858 0.010720925 0.975047809 1 39.83952048 41.86560313 23585 transmembrane protein 50A "GO:0005515,GO:0005783,GO:0016021,GO:0032511,GO:0043025,GO:0097386" protein binding|endoplasmic reticulum|integral component of membrane|late endosome to vacuole transport via multivesicular body sorting pathway|neuronal cell body|glial cell projection TMEM50B 613.7855884 603.8988012 623.6723757 1.032743192 0.04648155 0.909010728 1 9.551949985 10.28964308 757 transmembrane protein 50B "GO:0000139,GO:0003674,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0008150,GO:0016021,GO:0032511" Golgi membrane|molecular_function|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|biological_process|integral component of membrane|late endosome to vacuole transport via multivesicular body sorting pathway TMEM51 279.3397834 337.9803375 220.6992293 0.652994286 -0.614857726 0.203983018 1 6.095979975 4.152109925 55092 transmembrane protein 51 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane TMEM52 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.494797276 0.222672358 339456 transmembrane protein 52 GO:0016021 integral component of membrane TMEM53 67.814498 55.82257826 79.80641774 1.429644066 0.515656008 0.508990036 1 1.069699833 1.59516563 79639 transmembrane protein 53 "GO:0005634,GO:0016021" nucleus|integral component of membrane TMEM54 1017.986729 923.6099312 1112.363526 1.204365056 0.268272754 0.445569092 1 43.15275343 54.21039698 113452 transmembrane protein 54 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane TMEM59 2346.888961 2154.751521 2539.026401 1.178338373 0.236753885 0.459020905 1 15.84587818 19.476112 9528 transmembrane protein 59 "GO:0000137,GO:0000138,GO:0000139,GO:0004175,GO:0005515,GO:0005764,GO:0005765,GO:0005770,GO:0005797,GO:0005886,GO:0006508,GO:0006914,GO:0010508,GO:0010955,GO:0016021,GO:0031902,GO:0070062,GO:0090285,GO:1903077" Golgi cis cisterna|Golgi trans cisterna|Golgi membrane|endopeptidase activity|protein binding|lysosome|lysosomal membrane|late endosome|Golgi medial cisterna|plasma membrane|proteolysis|autophagy|positive regulation of autophagy|negative regulation of protein processing|integral component of membrane|late endosome membrane|extracellular exosome|negative regulation of protein glycosylation in Golgi|negative regulation of protein localization to plasma membrane TMEM59L 253.4638494 219.2304892 287.6972096 1.312304738 0.392102775 0.433681319 1 6.8496304 9.37600358 25789 transmembrane protein 59 like "GO:0000139,GO:0016020,GO:0016021" Golgi membrane|membrane|integral component of membrane TMEM60 458.8184891 382.6384001 534.9985782 1.398183188 0.483553393 0.247302687 1 22.0972464 32.22687274 85025 transmembrane protein 60 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM61 12.44941719 9.134603715 15.76423066 1.725770614 0.787240717 0.570104177 1 0.208394348 0.375132711 199964 transmembrane protein 61 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM62 334.8115062 358.2794568 311.3435556 0.868996393 -0.202577906 0.661116221 1 4.726645104 4.284369297 80021 transmembrane protein 62 "GO:0016021,GO:0016787" integral component of membrane|hydrolase activity TMEM63A 1573.177538 1361.055954 1785.299123 1.31170149 0.391439437 0.23519363 1 15.41773262 21.09460761 9725 transmembrane protein 63A "GO:0003676,GO:0005227,GO:0005515,GO:0005765,GO:0005886,GO:0008381,GO:0016021,GO:0034451,GO:0035579,GO:0043231,GO:0043312,GO:0070062,GO:0070821,GO:0098655,GO:1990760" nucleic acid binding|calcium activated cation channel activity|protein binding|lysosomal membrane|plasma membrane|mechanosensitive ion channel activity|integral component of membrane|centriolar satellite|specific granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|tertiary granule membrane|cation transmembrane transport|osmolarity-sensing cation channel activity TMEM63B 958.7857485 1052.509339 865.0621577 0.821904496 -0.282957331 0.425843116 1 12.94460539 11.09752422 55362 transmembrane protein 63B "GO:0005227,GO:0005886,GO:0008381,GO:0015629,GO:0016021,GO:0098655,GO:1990760" calcium activated cation channel activity|plasma membrane|mechanosensitive ion channel activity|actin cytoskeleton|integral component of membrane|cation transmembrane transport|osmolarity-sensing cation channel activity TMEM63C 18.83879012 8.119647747 29.5579325 3.640297389 1.864056314 0.109364662 1 0.07667938 0.291159782 57156 transmembrane protein 63C "GO:0003094,GO:0005227,GO:0005886,GO:0006812,GO:0016021,GO:0098655,GO:1990760" glomerular filtration|calcium activated cation channel activity|plasma membrane|cation transport|integral component of membrane|cation transmembrane transport|osmolarity-sensing cation channel activity TMEM64 525.9134628 658.7064235 393.1205022 0.596806845 -0.744664013 0.065504409 1 6.676237057 4.156056798 169200 transmembrane protein 64 "GO:0005783,GO:0016021,GO:0043462,GO:0045600,GO:0045668,GO:0045672,GO:0045780,GO:0051480,GO:0090090" endoplasmic reticulum|integral component of membrane|regulation of ATPase activity|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of osteoclast differentiation|positive regulation of bone resorption|regulation of cytosolic calcium ion concentration|negative regulation of canonical Wnt signaling pathway TMEM65 1536.598545 1419.9234 1653.273691 1.164340056 0.219512472 0.507100185 1 7.956861143 9.663568898 157378 transmembrane protein 65 "GO:0003231,GO:0005515,GO:0005743,GO:0005886,GO:0014704,GO:0016021,GO:1903779" cardiac ventricle development|protein binding|mitochondrial inner membrane|plasma membrane|intercalated disc|integral component of membrane|regulation of cardiac conduction TMEM67 699.9111096 732.7982092 667.02401 0.910242413 -0.135677285 0.721823853 1 8.419610739 7.994015955 91147 transmembrane protein 67 "GO:0005515,GO:0005789,GO:0005813,GO:0010826,GO:0016021,GO:0030433,GO:0030659,GO:0031005,GO:0035869,GO:0036038,GO:0051082,GO:0060170,GO:0060271,GO:0097711" protein binding|endoplasmic reticulum membrane|centrosome|negative regulation of centrosome duplication|integral component of membrane|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle membrane|filamin binding|ciliary transition zone|MKS complex|unfolded protein binding|ciliary membrane|cilium assembly|ciliary basal body-plasma membrane docking TMEM68 391.4345186 356.2495449 426.6194924 1.197529929 0.260061713 0.553304514 1 4.031906743 5.036313829 137695 transmembrane protein 68 "GO:0016021,GO:0016746" "integral component of membrane|transferase activity, transferring acyl groups" TMEM69 774.1473937 756.1421964 792.1525909 1.047623839 0.067120795 0.859090967 1 26.10493166 28.52619606 51249 transmembrane protein 69 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM70 772.9758151 844.4433657 701.5082646 0.830734532 -0.267540568 0.470276618 1 21.04728221 18.23787429 54968 transmembrane protein 70 "GO:0003674,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0032592,GO:0033615" molecular_function|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|integral component of mitochondrial membrane|mitochondrial proton-transporting ATP synthase complex assembly TMEM71 127.2690942 112.6601125 141.878076 1.259346124 0.332674854 0.60050976 1 2.059125679 2.704854411 137835 transmembrane protein 71 "GO:0005739,GO:0016021" mitochondrion|integral component of membrane TMEM74 22.10634467 29.43372308 14.77896625 0.502109985 -0.993924681 0.364274652 1 0.237261537 0.124263084 157753 transmembrane protein 74 "GO:0000421,GO:0005515,GO:0005765,GO:0016021,GO:0016236,GO:0031410" autophagosome membrane|protein binding|lysosomal membrane|integral component of membrane|macroautophagy|cytoplasmic vesicle TMEM74B 178.1532262 189.7967661 166.5096864 0.877305182 -0.188849305 0.74273104 1 1.91981958 1.756819087 55321 transmembrane protein 74B GO:0016021 integral component of membrane TMEM79 127.3851388 154.2733072 100.4969705 0.651421638 -0.618336453 0.32403637 1 3.625707084 2.463603572 84283 transmembrane protein 79 "GO:0002070,GO:0005515,GO:0005765,GO:0016021,GO:0031069,GO:0032588,GO:0042335,GO:0042802,GO:0045055,GO:0045684,GO:0061436,GO:0070268" epithelial cell maturation|protein binding|lysosomal membrane|integral component of membrane|hair follicle morphogenesis|trans-Golgi network membrane|cuticle development|identical protein binding|regulated exocytosis|positive regulation of epidermis development|establishment of skin barrier|cornification TMEM80 103.4297532 99.4656849 107.3938214 1.079707253 0.110640199 0.882531521 1 2.271229056 2.557896007 283232 transmembrane protein 80 "GO:0005515,GO:0016021,GO:0035869,GO:1905515" protein binding|integral component of membrane|ciliary transition zone|non-motile cilium assembly TMEM81 53.23124844 35.52345889 70.93903799 1.996963139 0.997807703 0.232429732 1 1.350704109 2.813495336 388730 transmembrane protein 81 GO:0016021 integral component of membrane TMEM86A 149.9868373 150.2134833 149.7601913 0.996982348 -0.004360133 1 1 2.10917189 2.193387547 144110 transmembrane protein 86A "GO:0005515,GO:0016021,GO:0047408,GO:0047409" protein binding|integral component of membrane|alkenylglycerophosphocholine hydrolase activity|alkenylglycerophosphoethanolamine hydrolase activity TMEM86B 30.91434131 25.37389921 36.45478341 1.436704036 0.522762895 0.608580815 1 0.857303857 1.284748204 255043 transmembrane protein 86B "GO:0005515,GO:0005737,GO:0005789,GO:0016020,GO:0016021,GO:0016803,GO:0036151,GO:0042802,GO:0046485,GO:0047408,GO:0047409" protein binding|cytoplasm|endoplasmic reticulum membrane|membrane|integral component of membrane|ether hydrolase activity|phosphatidylcholine acyl-chain remodeling|identical protein binding|ether lipid metabolic process|alkenylglycerophosphocholine hydrolase activity|alkenylglycerophosphoethanolamine hydrolase activity hsa00565 Ether lipid metabolism TMEM87A 707.2884685 698.2897062 716.2872308 1.025773722 0.036712518 0.926219288 1 6.647727482 7.112801789 25963 transmembrane protein 87A "GO:0005794,GO:0005829,GO:0006810,GO:0016020,GO:0016021,GO:0032580,GO:0042147" "Golgi apparatus|cytosol|transport|membrane|integral component of membrane|Golgi cisterna membrane|retrograde transport, endosome to Golgi" TMEM87B 1161.052467 1004.806409 1317.298525 1.310997336 0.390664754 0.255989043 1 10.80006364 14.76876069 84910 transmembrane protein 87B "GO:0000139,GO:0005794,GO:0005829,GO:0006810,GO:0016020,GO:0016021,GO:0042147" "Golgi membrane|Golgi apparatus|cytosol|transport|membrane|integral component of membrane|retrograde transport, endosome to Golgi" TMEM88 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.140704213 0.189962276 92162 transmembrane protein 88 "GO:0005515,GO:0005829,GO:0005886,GO:0007275,GO:0016021,GO:0016055,GO:0030165,GO:0050821,GO:0072659,GO:0090090" protein binding|cytosol|plasma membrane|multicellular organism development|integral component of membrane|Wnt signaling pathway|PDZ domain binding|protein stabilization|protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway TMEM8B 259.9719885 226.3351809 293.6087961 1.297230041 0.375434339 0.449919328 1 1.87274603 2.534030352 51754 transmembrane protein 8B "GO:0005515,GO:0005634,GO:0005739,GO:0005783,GO:0005886,GO:0007160,GO:0007346,GO:0009986,GO:0016021,GO:0040008" protein binding|nucleus|mitochondrion|endoplasmic reticulum|plasma membrane|cell-matrix adhesion|regulation of mitotic cell cycle|cell surface|integral component of membrane|regulation of growth TMEM9 2703.774153 2944.387264 2463.161041 0.836561505 -0.257456482 0.41910835 1 69.74875012 60.8625628 252839 transmembrane protein 9 "GO:0003674,GO:0005515,GO:0005764,GO:0005765,GO:0005770,GO:0007042,GO:0015031,GO:0015630,GO:0016021,GO:0032585,GO:0042176,GO:0043231,GO:0045171,GO:0048388,GO:0070070,GO:0072686,GO:0090263" molecular_function|protein binding|lysosome|lysosomal membrane|late endosome|lysosomal lumen acidification|protein transport|microtubule cytoskeleton|integral component of membrane|multivesicular body membrane|regulation of protein catabolic process|intracellular membrane-bounded organelle|intercellular bridge|endosomal lumen acidification|proton-transporting V-type ATPase complex assembly|mitotic spindle|positive regulation of canonical Wnt signaling pathway TMEM91 26.94359209 23.34398727 30.54319691 1.308396743 0.387800073 0.727721286 1 0.819328207 1.118184044 641649 transmembrane protein 91 "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane TMEM92 64.73993854 47.70293051 81.77694657 1.714296076 0.777616298 0.322162488 1 0.85794927 1.534134264 162461 transmembrane protein 92 "GO:0005515,GO:0005654,GO:0016021" protein binding|nucleoplasm|integral component of membrane TMEM94 1475.124924 1225.051854 1725.197993 1.408265281 0.493919126 0.137408178 1 10.48404101 15.40029759 9772 transmembrane protein 94 GO:0016021 integral component of membrane TMEM97 1063.165877 846.4732776 1279.858477 1.511989227 0.596447861 0.087648707 1 16.35045207 25.78661829 27346 transmembrane protein 97 "GO:0001558,GO:0005515,GO:0005764,GO:0005783,GO:0005791,GO:0005886,GO:0016021,GO:0030867,GO:0031965,GO:0042632" regulation of cell growth|protein binding|lysosome|endoplasmic reticulum|rough endoplasmic reticulum|plasma membrane|integral component of membrane|rough endoplasmic reticulum membrane|nuclear membrane|cholesterol homeostasis TMEM98 1284.901589 951.0137424 1618.789436 1.702172497 0.767377246 0.02392034 0.684653464 11.2273872 19.9341719 26022 transmembrane protein 98 "GO:0005515,GO:0005615,GO:0005783,GO:0005789,GO:0005886,GO:0010955,GO:0016021,GO:0031642,GO:0045063,GO:0048715,GO:0070062,GO:1900181" protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|negative regulation of protein processing|integral component of membrane|negative regulation of myelination|T-helper 1 cell differentiation|negative regulation of oligodendrocyte differentiation|extracellular exosome|negative regulation of protein localization to nucleus TMEM9B 690.0342171 663.7812033 716.2872308 1.079101408 0.109830447 0.774711284 1 17.67517154 19.894903 56674 TMEM9 domain family member B "GO:0005515,GO:0005765,GO:0016021,GO:0031901,GO:0043123" protein binding|lysosomal membrane|integral component of membrane|early endosome membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling TMF1 1625.58262 1643.213713 1607.951528 0.978540719 -0.03129621 0.925960244 1 12.08231383 12.3323245 7110 TATA element modulatory factor 1 "GO:0000139,GO:0001675,GO:0001819,GO:0003677,GO:0005515,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0007289,GO:0010629,GO:0030317,GO:0030374,GO:0030521,GO:0032275,GO:0033327,GO:0042742,GO:0043066,GO:0045944,GO:0050681,GO:0061136,GO:2000845" Golgi membrane|acrosome assembly|positive regulation of cytokine production|DNA binding|protein binding|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|spermatid nucleus differentiation|negative regulation of gene expression|flagellated sperm motility|nuclear receptor coactivator activity|androgen receptor signaling pathway|luteinizing hormone secretion|Leydig cell differentiation|defense response to bacterium|negative regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|androgen receptor binding|regulation of proteasomal protein catabolic process|positive regulation of testosterone secretion TMIE 4.463381426 2.029911937 6.896850916 3.397610897 1.764520641 0.414871268 1 0.044776951 0.158687999 259236 transmembrane inner ear "GO:0007605,GO:0016021,GO:0042472" sensory perception of sound|integral component of membrane|inner ear morphogenesis TMLHE 289.4678163 255.768904 323.1667286 1.263510628 0.3374378 0.482372157 1 2.984057289 3.932801128 55217 "trimethyllysine hydroxylase, epsilon" "GO:0005506,GO:0005739,GO:0005759,GO:0045329,GO:0050353,GO:0055114" iron ion binding|mitochondrion|mitochondrial matrix|carnitine biosynthetic process|trimethyllysine dioxygenase activity|oxidation-reduction process hsa00310 Lysine degradation TMOD1 130.014325 131.9442759 128.0843742 0.970745971 -0.042834281 0.958389221 1 2.294818716 2.323645701 7111 tropomodulin 1 "GO:0003779,GO:0005523,GO:0005829,GO:0005856,GO:0005865,GO:0005884,GO:0006936,GO:0007015,GO:0008180,GO:0008344,GO:0016020,GO:0030016,GO:0030017,GO:0030049,GO:0030239,GO:0030863,GO:0051015,GO:0051694,GO:0070307" actin binding|tropomyosin binding|cytosol|cytoskeleton|striated muscle thin filament|actin filament|muscle contraction|actin filament organization|COP9 signalosome|adult locomotory behavior|membrane|myofibril|sarcomere|muscle filament sliding|myofibril assembly|cortical cytoskeleton|actin filament binding|pointed-end actin filament capping|lens fiber cell development TMOD2 518.3918516 447.5955821 589.1881211 1.316340341 0.396532547 0.327887827 1 2.467791989 3.388384378 29767 tropomodulin 2 "GO:0003779,GO:0005515,GO:0005523,GO:0005856,GO:0005865,GO:0006936,GO:0007015,GO:0007270,GO:0007399,GO:0007611,GO:0030016,GO:0030239,GO:0030426,GO:0045202,GO:0045745,GO:0051694" actin binding|protein binding|tropomyosin binding|cytoskeleton|striated muscle thin filament|muscle contraction|actin filament organization|neuron-neuron synaptic transmission|nervous system development|learning or memory|myofibril|myofibril assembly|growth cone|synapse|positive regulation of G protein-coupled receptor signaling pathway|pointed-end actin filament capping TMOD3 1200.236151 1225.051854 1175.420449 0.959486282 -0.059665914 0.863678014 1 13.13390234 13.14463353 29766 tropomodulin 3 "GO:0003779,GO:0005523,GO:0005856,GO:0005865,GO:0005912,GO:0006936,GO:0007015,GO:0030016,GO:0030239,GO:0048821,GO:0051694,GO:0098609,GO:0098641,GO:1901992" actin binding|tropomyosin binding|cytoskeleton|striated muscle thin filament|adherens junction|muscle contraction|actin filament organization|myofibril|myofibril assembly|erythrocyte development|pointed-end actin filament capping|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of mitotic cell cycle phase transition TMOD4 8.567742628 13.19442759 3.941057666 0.298691068 -1.743273999 0.256867275 1 0.541971784 0.168855357 29765 tropomodulin 4 "GO:0005515,GO:0005523,GO:0005856,GO:0005865,GO:0006936,GO:0007015,GO:0030016,GO:0030239,GO:0051015,GO:0051694" protein binding|tropomyosin binding|cytoskeleton|striated muscle thin filament|muscle contraction|actin filament organization|myofibril|myofibril assembly|actin filament binding|pointed-end actin filament capping TMPO 4502.010381 4300.368438 4703.652325 1.093778915 0.129321156 0.686177635 1 30.26239969 34.5262046 7112 thymopoietin "GO:0000785,GO:0003677,GO:0005515,GO:0005521,GO:0005634,GO:0005635,GO:0006355,GO:0045296" "chromatin|DNA binding|protein binding|lamin binding|nucleus|nuclear envelope|regulation of transcription, DNA-templated|cadherin binding" TMPPE 76.06775773 81.19647747 70.93903799 0.873671373 -0.194837375 0.807036427 1 0.954133443 0.869507143 643853 transmembrane protein with metallophosphoesterase domain "GO:0005515,GO:0016021,GO:0016787,GO:0046872" protein binding|integral component of membrane|hydrolase activity|metal ion binding TMPRSS2 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.043788276 7113 transmembrane serine protease 2 "GO:0004252,GO:0005044,GO:0005515,GO:0005654,GO:0005886,GO:0005887,GO:0006508,GO:0006897,GO:0008236,GO:0016540,GO:0046598,GO:0070062" serine-type endopeptidase activity|scavenger receptor activity|protein binding|nucleoplasm|plasma membrane|integral component of plasma membrane|proteolysis|endocytosis|serine-type peptidase activity|protein autoprocessing|positive regulation of viral entry into host cell|extracellular exosome "hsa05164,hsa05171,hsa05202,hsa05215" Influenza A|Coronavirus disease - COVID-19|Transcriptional misregulation in cancer|Prostate cancer TMPRSS5 5.552566274 9.134603715 1.970528833 0.215721327 -2.212759283 0.247208451 1 0.20344567 0.045778068 80975 transmembrane serine protease 5 "GO:0004252,GO:0005044,GO:0005886,GO:0006508,GO:0006897,GO:0008233,GO:0016021,GO:0043025" serine-type endopeptidase activity|scavenger receptor activity|plasma membrane|proteolysis|endocytosis|peptidase activity|integral component of membrane|neuronal cell body TMPRSS9 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.059855542 0.03636446 360200 transmembrane serine protease 9 "GO:0004252,GO:0005887,GO:0006508" serine-type endopeptidase activity|integral component of plasma membrane|proteolysis TMSB10 15530.93634 16113.44095 14948.43173 0.927699538 -0.108270472 0.758348053 1 1770.258003 1713.009757 9168 thymosin beta 10 "GO:0003785,GO:0005515,GO:0005737,GO:0005856,GO:0007015,GO:0030334,GO:0042989" actin monomer binding|protein binding|cytoplasm|cytoskeleton|actin filament organization|regulation of cell migration|sequestering of actin monomers TMSB15B 11.01605789 12.17947162 9.852644165 0.808954975 -0.305868687 0.884333199 1 0.204864587 0.172865041 286527 thymosin beta 15B "GO:0003674,GO:0003785,GO:0005575,GO:0005737,GO:0005856,GO:0007015,GO:0030334,GO:0030335,GO:0042989" molecular_function|actin monomer binding|cellular_component|cytoplasm|cytoskeleton|actin filament organization|regulation of cell migration|positive regulation of cell migration|sequestering of actin monomers TMSB4X 15938.7794 17726.20599 14151.35281 0.79832948 -0.324943808 0.357517906 1 1443.359805 1201.91209 7114 thymosin beta 4 X-linked "GO:0002576,GO:0003723,GO:0003785,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0007015,GO:0007253,GO:0019899,GO:0030334,GO:0031093,GO:0032088,GO:0032717,GO:0033209,GO:0042989,GO:0043536,GO:0050727,GO:1901222,GO:1901223,GO:1903026,GO:1905273,GO:2001028,GO:2001171" "platelet degranulation|RNA binding|actin monomer binding|protein binding|extracellular region|nucleus|cytoplasm|cytosol|cytoskeleton|actin filament organization|cytoplasmic sequestering of NF-kappaB|enzyme binding|regulation of cell migration|platelet alpha granule lumen|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-8 production|tumor necrosis factor-mediated signaling pathway|sequestering of actin monomers|positive regulation of blood vessel endothelial cell migration|regulation of inflammatory response|regulation of NIK/NF-kappaB signaling|negative regulation of NIK/NF-kappaB signaling|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|positive regulation of proton-transporting ATP synthase activity, rotational mechanism|positive regulation of endothelial cell chemotaxis|positive regulation of ATP biosynthetic process" hsa04810 Regulation of actin cytoskeleton TMTC1 36.48175336 35.52345889 37.44004783 1.053952768 0.075810215 0.967396769 1 0.111719938 0.122819624 83857 transmembrane O-mannosyltransferase targeting cadherins 1 "GO:0000030,GO:0004169,GO:0005783,GO:0006396,GO:0016021,GO:0035269" mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|endoplasmic reticulum|RNA processing|integral component of membrane|protein O-linked mannosylation TMTC2 459.2611408 446.5806261 471.9416555 1.056789363 0.079687851 0.853310071 1 2.18507712 2.408635776 160335 transmembrane O-mannosyltransferase targeting cadherins 2 "GO:0000030,GO:0004169,GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0035269,GO:0055074" mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|protein O-linked mannosylation|calcium ion homeostasis TMTC3 611.7705223 600.8539333 622.6871113 1.036336914 0.051493101 0.898821534 1 4.231247502 4.57388591 160418 transmembrane O-mannosyltransferase targeting cadherins 3 "GO:0000030,GO:0004169,GO:0005515,GO:0005783,GO:0016021,GO:0034976,GO:0035269,GO:1901800" mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding|endoplasmic reticulum|integral component of membrane|response to endoplasmic reticulum stress|protein O-linked mannosylation|positive regulation of proteasomal protein catabolic process TMTC4 288.301681 277.0829794 299.5203826 1.080977198 0.112336091 0.820567926 1 2.534912467 2.858218527 84899 transmembrane O-mannosyltransferase targeting cadherins 4 "GO:0000030,GO:0004169,GO:0005783,GO:0007605,GO:0016021,GO:0030968,GO:0032470,GO:0035269,GO:0051117,GO:1905584" mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|endoplasmic reticulum|sensory perception of sound|integral component of membrane|endoplasmic reticulum unfolded protein response|positive regulation of endoplasmic reticulum calcium ion concentration|protein O-linked mannosylation|ATPase binding|outer hair cell apoptotic process TMUB1 961.4649152 966.2380819 956.6917485 0.990120102 -0.014324559 0.97101639 1 31.55161197 32.58557283 83590 transmembrane and ubiquitin like domain containing 1 "GO:0005515,GO:0005730,GO:0005815,GO:0016021,GO:0030433,GO:0045211,GO:0055037" protein binding|nucleolus|microtubule organizing center|integral component of membrane|ubiquitin-dependent ERAD pathway|postsynaptic membrane|recycling endosome TMUB2 1006.873431 1005.821365 1007.925498 1.002091955 0.003014901 0.996397234 1 18.58493389 19.42605107 79089 transmembrane and ubiquitin like domain containing 2 "GO:0005515,GO:0016021,GO:0030433" protein binding|integral component of membrane|ubiquitin-dependent ERAD pathway TMX1 1452.065482 1534.613424 1369.517539 0.892418584 -0.164207538 0.622669881 1 19.31000153 17.97491492 81542 thioredoxin related transmembrane protein 1 "GO:0005515,GO:0005789,GO:0015036,GO:0016021,GO:0034976,GO:0055114" protein binding|endoplasmic reticulum membrane|disulfide oxidoreductase activity|integral component of membrane|response to endoplasmic reticulum stress|oxidation-reduction process TMX2 1965.279871 2133.437446 1797.122296 0.842359967 -0.247491221 0.443279193 1 59.27102595 52.07821536 51075 thioredoxin related transmembrane protein 2 "GO:0005515,GO:0005739,GO:0005789,GO:0007420,GO:0015036,GO:0016021,GO:0031966,GO:0042802,GO:0043227,GO:0044233,GO:0055114" protein binding|mitochondrion|endoplasmic reticulum membrane|brain development|disulfide oxidoreductase activity|integral component of membrane|mitochondrial membrane|identical protein binding|membrane-bounded organelle|mitochondria-associated endoplasmic reticulum membrane|oxidation-reduction process TMX3 2213.348022 1882.743321 2543.952724 1.351194661 0.434235533 0.175524569 1 12.78722104 18.02229203 54495 thioredoxin related transmembrane protein 3 "GO:0002576,GO:0003756,GO:0005515,GO:0005789,GO:0005886,GO:0009986,GO:0016021,GO:0016972,GO:0018171,GO:0018215,GO:0031092" platelet degranulation|protein disulfide isomerase activity|protein binding|endoplasmic reticulum membrane|plasma membrane|cell surface|integral component of membrane|thiol oxidase activity|peptidyl-cysteine oxidation|protein phosphopantetheinylation|platelet alpha granule membrane TMX4 1557.819341 1691.931599 1423.707082 0.841468463 -0.249018893 0.450806602 1 14.04069584 12.32373653 56255 thioredoxin related transmembrane protein 4 "GO:0005637,GO:0016021,GO:0055114" nuclear inner membrane|integral component of membrane|oxidation-reduction process TNC 9259.391321 13463.39092 5055.391721 0.375491713 -1.413147026 3.33E-05 0.006630516 74.49724179 29.17806451 3371 tenascin C "GO:0001649,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0005614,GO:0005615,GO:0005788,GO:0005925,GO:0007155,GO:0007162,GO:0007528,GO:0008284,GO:0009611,GO:0009612,GO:0010628,GO:0014012,GO:0016020,GO:0030198,GO:0042060,GO:0042475,GO:0043687,GO:0044267,GO:0045471,GO:0045545,GO:0060447,GO:0060739,GO:0060740,GO:0062023,GO:0071300,GO:0071305,GO:0071774,GO:0071799,GO:0098966" osteoblast differentiation|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|interstitial matrix|extracellular space|endoplasmic reticulum lumen|focal adhesion|cell adhesion|negative regulation of cell adhesion|neuromuscular junction development|positive regulation of cell population proliferation|response to wounding|response to mechanical stimulus|positive regulation of gene expression|peripheral nervous system axon regeneration|membrane|extracellular matrix organization|wound healing|odontogenesis of dentin-containing tooth|post-translational protein modification|cellular protein metabolic process|response to ethanol|syndecan binding|bud outgrowth involved in lung branching|mesenchymal-epithelial cell signaling involved in prostate gland development|prostate gland epithelium morphogenesis|collagen-containing extracellular matrix|cellular response to retinoic acid|cellular response to vitamin D|response to fibroblast growth factor|cellular response to prostaglandin D stimulus|perisynaptic extracellular matrix "hsa04151,hsa04510,hsa04512,hsa05165,hsa05206" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Human papillomavirus infection|MicroRNAs in cancer TNF 575.7368638 562.2856065 589.1881211 1.047844928 0.067425227 0.868409182 1 16.97126481 18.54928421 7124 tumor necrosis factor "GO:0000122,GO:0000165,GO:0000185,GO:0000187,GO:0000976,GO:0001774,GO:0001819,GO:0001891,GO:0001934,GO:0001937,GO:0002020,GO:0002439,GO:0002637,GO:0002719,GO:0002876,GO:0002925,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0005887,GO:0006006,GO:0006357,GO:0006919,GO:0006954,GO:0006959,GO:0007249,GO:0007254,GO:0008625,GO:0008630,GO:0009615,GO:0009651,GO:0009897,GO:0009986,GO:0010573,GO:0010628,GO:0010629,GO:0010693,GO:0010803,GO:0010888,GO:0014068,GO:0019221,GO:0030198,GO:0030316,GO:0030730,GO:0030866,GO:0031334,GO:0031622,GO:0031663,GO:0032715,GO:0032722,GO:0032724,GO:0032729,GO:0032731,GO:0032755,GO:0032757,GO:0033138,GO:0033209,GO:0034116,GO:0035509,GO:0042531,GO:0042802,GO:0043065,GO:0043068,GO:0043122,GO:0043123,GO:0043154,GO:0043242,GO:0043243,GO:0043280,GO:0043406,GO:0043491,GO:0043507,GO:0043525,GO:0043537,GO:0045071,GO:0045121,GO:0045429,GO:0045598,GO:0045599,GO:0045662,GO:0045668,GO:0045672,GO:0045732,GO:0045785,GO:0045860,GO:0045892,GO:0045893,GO:0045930,GO:0045944,GO:0045994,GO:0046325,GO:0046330,GO:0046427,GO:0048143,GO:0048566,GO:0048661,GO:0050729,GO:0050766,GO:0050768,GO:0050796,GO:0050806,GO:0050807,GO:0050830,GO:0050890,GO:0050901,GO:0050995,GO:0051000,GO:0051044,GO:0051091,GO:0051092,GO:0051173,GO:0051222,GO:0051384,GO:0051798,GO:0051897,GO:0051966,GO:0055037,GO:0060252,GO:0060557,GO:0060559,GO:0060664,GO:0060693,GO:0061044,GO:0061048,GO:0070374,GO:0070886,GO:0071230,GO:0071316,GO:0071407,GO:0071550,GO:0071677,GO:0071803,GO:0072577,GO:0072659,GO:0097191,GO:0097527,GO:0150078,GO:0150129,GO:1900017,GO:1900222,GO:1901224,GO:1901647,GO:1901671,GO:1902004,GO:1902895,GO:1903078,GO:1903140,GO:1903347,GO:1903721,GO:1903799,GO:1904707,GO:1904996,GO:1904999,GO:2000010,GO:2000272,GO:2000304,GO:2000334,GO:2000343,GO:2000351,GO:2001234,GO:2001238,GO:2001240" "negative regulation of transcription by RNA polymerase II|MAPK cascade|activation of MAPKKK activity|activation of MAPK activity|transcription regulatory region sequence-specific DNA binding|microglial cell activation|positive regulation of cytokine production|phagocytic cup|positive regulation of protein phosphorylation|negative regulation of endothelial cell proliferation|protease binding|chronic inflammatory response to antigenic stimulus|regulation of immunoglobulin production|negative regulation of cytokine production involved in immune response|positive regulation of chronic inflammatory response to antigenic stimulus|positive regulation of humoral immune response mediated by circulating immunoglobulin|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular region|extracellular space|plasma membrane|integral component of plasma membrane|glucose metabolic process|regulation of transcription by RNA polymerase II|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|humoral immune response|I-kappaB kinase/NF-kappaB signaling|JNK cascade|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|response to virus|response to salt stress|external side of plasma membrane|cell surface|vascular endothelial growth factor production|positive regulation of gene expression|negative regulation of gene expression|negative regulation of alkaline phosphatase activity|regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of lipid storage|positive regulation of phosphatidylinositol 3-kinase signaling|cytokine-mediated signaling pathway|extracellular matrix organization|osteoclast differentiation|sequestering of triglyceride|cortical actin cytoskeleton organization|positive regulation of protein-containing complex assembly|positive regulation of fever generation|lipopolysaccharide-mediated signaling pathway|negative regulation of interleukin-6 production|positive regulation of chemokine production|positive regulation of fractalkine production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of peptidyl-serine phosphorylation|tumor necrosis factor-mediated signaling pathway|positive regulation of heterotypic cell-cell adhesion|negative regulation of myosin-light-chain-phosphatase activity|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|positive regulation of apoptotic process|positive regulation of programmed cell death|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of protein-containing complex disassembly|positive regulation of protein-containing complex disassembly|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of MAP kinase activity|protein kinase B signaling|positive regulation of JUN kinase activity|positive regulation of neuron apoptotic process|negative regulation of blood vessel endothelial cell migration|negative regulation of viral genome replication|membrane raft|positive regulation of nitric oxide biosynthetic process|regulation of fat cell differentiation|negative regulation of fat cell differentiation|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|positive regulation of osteoclast differentiation|positive regulation of protein catabolic process|positive regulation of cell adhesion|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|positive regulation of translational initiation by iron|negative regulation of glucose import|positive regulation of JNK cascade|positive regulation of receptor signaling pathway via JAK-STAT|astrocyte activation|embryonic digestive tract development|positive regulation of smooth muscle cell proliferation|positive regulation of inflammatory response|positive regulation of phagocytosis|negative regulation of neurogenesis|regulation of insulin secretion|positive regulation of synaptic transmission|regulation of synapse organization|defense response to Gram-positive bacterium|cognition|leukocyte tethering or rolling|negative regulation of lipid catabolic process|positive regulation of nitric-oxide synthase activity|positive regulation of membrane protein ectodomain proteolysis|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitrogen compound metabolic process|positive regulation of protein transport|response to glucocorticoid|positive regulation of hair follicle development|positive regulation of protein kinase B signaling|regulation of synaptic transmission, glutamatergic|recycling endosome|positive regulation of glial cell proliferation|positive regulation of vitamin D biosynthetic process|positive regulation of calcidiol 1-monooxygenase activity|epithelial cell proliferation involved in salivary gland morphogenesis|regulation of branching involved in salivary gland morphogenesis|negative regulation of vascular wound healing|negative regulation of branching involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of calcineurin-NFAT signaling cascade|cellular response to amino acid stimulus|cellular response to nicotine|cellular response to organic cyclic compound|death-inducing signaling complex assembly|positive regulation of mononuclear cell migration|positive regulation of podosome assembly|endothelial cell apoptotic process|protein localization to plasma membrane|extrinsic apoptotic signaling pathway|necroptotic signaling pathway|positive regulation of neuroinflammatory response|positive regulation of interleukin-33 production|positive regulation of cytokine production involved in inflammatory response|negative regulation of amyloid-beta clearance|positive regulation of NIK/NF-kappaB signaling|positive regulation of synoviocyte proliferation|positive regulation of superoxide dismutase activity|positive regulation of amyloid-beta formation|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of protein localization to plasma membrane|regulation of establishment of endothelial barrier|negative regulation of bicellular tight junction assembly|positive regulation of I-kappaB phosphorylation|negative regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of leukocyte adhesion to arterial endothelial cell|positive regulation of protein localization to cell surface|negative regulation of signaling receptor activity|positive regulation of ceramide biosynthetic process|positive regulation of blood microparticle formation|positive regulation of chemokine (C-X-C motif) ligand 2 production|regulation of endothelial cell apoptotic process|negative regulation of apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa01523,hsa04010,hsa04060,hsa04061,hsa04064,hsa04071,hsa04150,hsa04210,hsa04217,hsa04350,hsa04380,hsa04612,hsa04620,hsa04621,hsa04622,hsa04625,hsa04640,hsa04650,hsa04657,hsa04660,hsa04664,hsa04668,hsa04920,hsa04930,hsa04931,hsa04932,hsa04933,hsa04940,hsa05010,hsa05014,hsa05020,hsa05022,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05143,hsa05144,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05168,hsa05169,hsa05170,hsa05171,hsa05205,hsa05310,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05410,hsa05414,hsa05418" Antifolate resistance|MAPK signaling pathway|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NF-kappa B signaling pathway|Sphingolipid signaling pathway|mTOR signaling pathway|Apoptosis|Necroptosis|TGF-beta signaling pathway|Osteoclast differentiation|Antigen processing and presentation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|Hematopoietic cell lineage|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Type I diabetes mellitus|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|African trypanosomiasis|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|Asthma|Inflammatory bowel disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Hypertrophic cardiomyopathy|Dilated cardiomyopathy|Fluid shear stress and atherosclerosis TNFAIP1 2264.538473 2048.181144 2480.895801 1.211267767 0.276517827 0.38769416 1 28.34239055 35.80903093 7126 TNF alpha induced protein 1 "GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0006915,GO:0006955,GO:0016477,GO:0016567,GO:0031267,GO:0031463,GO:0035024,GO:0042802,GO:0043149,GO:0043161,GO:0045740,GO:0051260" ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|endosome|apoptotic process|immune response|cell migration|protein ubiquitination|small GTPase binding|Cul3-RING ubiquitin ligase complex|negative regulation of Rho protein signal transduction|identical protein binding|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of DNA replication|protein homooligomerization TNFAIP2 2798.150212 3132.154118 2464.146306 0.786725753 -0.346067286 0.277219994 1 36.5597042 30.00143096 7127 TNF alpha induced protein 2 "GO:0000145,GO:0000149,GO:0001525,GO:0005515,GO:0005615,GO:0006887,GO:0030154,GO:0051601" exocyst|SNARE binding|angiogenesis|protein binding|extracellular space|exocytosis|cell differentiation|exocyst localization TNFAIP3 2105.623142 2466.343003 1744.903282 0.707486055 -0.499226383 0.120481472 1 21.01119804 15.50545911 7128 TNF alpha induced protein 3 "GO:0001922,GO:0002020,GO:0002237,GO:0002634,GO:0002677,GO:0003677,GO:0004842,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005829,GO:0006915,GO:0006954,GO:0007010,GO:0008022,GO:0008234,GO:0008270,GO:0010803,GO:0016477,GO:0016579,GO:0018215,GO:0019900,GO:0030177,GO:0031397,GO:0032088,GO:0032480,GO:0032495,GO:0032691,GO:0032703,GO:0032715,GO:0032720,GO:0034136,GO:0034140,GO:0034144,GO:0034148,GO:0035523,GO:0035871,GO:0042802,GO:0043124,GO:0043130,GO:0043621,GO:0045732,GO:0045736,GO:0045779,GO:0045824,GO:0048662,GO:0050691,GO:0050728,GO:0050869,GO:0061043,GO:0061578,GO:0070062,GO:0070301,GO:0070423,GO:0070429,GO:0070433,GO:0070530,GO:0070536,GO:0070936,GO:0071108,GO:0071222,GO:0071947,GO:0072573,GO:0072666,GO:0090291,GO:1902042,GO:1903364,GO:1990168,GO:2000347,GO:2000349,GO:2000352" B-1 B cell homeostasis|protease binding|response to molecule of bacterial origin|regulation of germinal center formation|negative regulation of chronic inflammatory response|DNA binding|ubiquitin-protein transferase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|lysosome|cytosol|apoptotic process|inflammatory response|cytoskeleton organization|protein C-terminus binding|cysteine-type peptidase activity|zinc ion binding|regulation of tumor necrosis factor-mediated signaling pathway|cell migration|protein deubiquitination|protein phosphopantetheinylation|kinase binding|positive regulation of Wnt signaling pathway|negative regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|response to muramyl dipeptide|negative regulation of interleukin-1 beta production|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of toll-like receptor 5 signaling pathway|protein K29-linked deubiquitination|protein K11-linked deubiquitination|identical protein binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|protein self-association|positive regulation of protein catabolic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of bone resorption|negative regulation of innate immune response|negative regulation of smooth muscle cell proliferation|regulation of defense response to virus by host|negative regulation of inflammatory response|negative regulation of B cell activation|regulation of vascular wound healing|Lys63-specific deubiquitinase activity|extracellular exosome|cellular response to hydrogen peroxide|nucleotide-binding oligomerization domain containing signaling pathway|negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein K48-linked ubiquitination|protein K48-linked deubiquitination|cellular response to lipopolysaccharide|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|tolerance induction to lipopolysaccharide|establishment of protein localization to vacuole|negative regulation of osteoclast proliferation|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of cellular protein catabolic process|protein K33-linked deubiquitination|positive regulation of hepatocyte proliferation|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptotic process "hsa04064,hsa04217,hsa04621,hsa04657,hsa04668,hsa05162,hsa05169" NF-kappa B signaling pathway|Necroptosis|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Measles|Epstein-Barr virus infection TNFAIP6 5.508028946 6.08973581 4.926322083 0.808954975 -0.305868687 0.976518791 1 0.216894258 0.183015695 7130 TNF alpha induced protein 6 "GO:0005515,GO:0005540,GO:0005576,GO:0005615,GO:0006954,GO:0007155,GO:0007165,GO:0007267,GO:0030335,GO:0030728,GO:0043312,GO:0050728,GO:1904724,GO:1904813" protein binding|hyaluronic acid binding|extracellular region|extracellular space|inflammatory response|cell adhesion|signal transduction|cell-cell signaling|positive regulation of cell migration|ovulation|neutrophil degranulation|negative regulation of inflammatory response|tertiary granule lumen|ficolin-1-rich granule lumen TNFAIP8 350.6175526 394.8178717 306.4172335 0.776097678 -0.365689856 0.418222389 1 6.079699717 4.921692129 25816 TNF alpha induced protein 8 "GO:0005515,GO:0005654,GO:0005737,GO:0006915,GO:0043027,GO:0043065,GO:0043066,GO:0043154" protein binding|nucleoplasm|cytoplasm|apoptotic process|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TNFAIP8L1 565.1891898 481.089129 649.2892505 1.349623617 0.432557125 0.275576215 1 5.11772048 7.20452182 126282 TNF alpha induced protein 8 like 1 "GO:0005515,GO:0005737,GO:0032007,GO:0042802,GO:0042981" protein binding|cytoplasm|negative regulation of TOR signaling|identical protein binding|regulation of apoptotic process TNFAIP8L3 21.42071737 16.23929549 26.60213925 1.638133825 0.712053221 0.528998684 1 0.331905984 0.567127086 388121 TNF alpha induced protein 8 like 3 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006644,GO:0008526,GO:0015914,GO:0019216,GO:0035091,GO:0042981,GO:0043552,GO:0048017,GO:0051897,GO:0070374,GO:0120009" protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|phospholipid metabolic process|phosphatidylinositol transfer activity|phospholipid transport|regulation of lipid metabolic process|phosphatidylinositol binding|regulation of apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|inositol lipid-mediated signaling|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|intermembrane lipid transfer TNFRSF10A 362.0371681 400.9076075 323.1667286 0.806087793 -0.31099112 0.487618211 1 7.548162083 6.346576095 8797 TNF receptor superfamily member 10a "GO:0002020,GO:0005035,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0006915,GO:0006919,GO:0007165,GO:0007166,GO:0007250,GO:0008134,GO:0008625,GO:0009986,GO:0016021,GO:0036462,GO:0038023,GO:0042802,GO:0042981,GO:0043065,GO:0045121,GO:0045569,GO:0050900,GO:0071260,GO:0097191,GO:1902041,GO:1902042" protease binding|death receptor activity|protein binding|Golgi apparatus|cytosol|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|cell surface receptor signaling pathway|activation of NF-kappaB-inducing kinase activity|transcription factor binding|extrinsic apoptotic signaling pathway via death domain receptors|cell surface|integral component of membrane|TRAIL-activated apoptotic signaling pathway|signaling receptor activity|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|membrane raft|TRAIL binding|leukocyte migration|cellular response to mechanical stimulus|extrinsic apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors "hsa04060,hsa04061,hsa04115,hsa04210,hsa04217,hsa04650,hsa05130,hsa05132,hsa05164" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|p53 signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|Pathogenic Escherichia coli infection|Salmonella infection|Influenza A TNFRSF10B 2439.921974 2520.135669 2359.708278 0.936341764 -0.094892887 0.767110749 1 31.92495777 31.18032631 8795 TNF receptor superfamily member 10b "GO:0005515,GO:0005886,GO:0006915,GO:0006919,GO:0007166,GO:0007250,GO:0008625,GO:0009986,GO:0016021,GO:0034976,GO:0036462,GO:0038023,GO:0042981,GO:0043065,GO:0043123,GO:0045569,GO:0050900,GO:0070059,GO:0071260,GO:1902041,GO:1902042" protein binding|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell surface receptor signaling pathway|activation of NF-kappaB-inducing kinase activity|extrinsic apoptotic signaling pathway via death domain receptors|cell surface|integral component of membrane|response to endoplasmic reticulum stress|TRAIL-activated apoptotic signaling pathway|signaling receptor activity|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|TRAIL binding|leukocyte migration|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to mechanical stimulus|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors "hsa04060,hsa04061,hsa04115,hsa04210,hsa04217,hsa04650,hsa05130,hsa05132,hsa05164" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|p53 signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|Pathogenic Escherichia coli infection|Salmonella infection|Influenza A TNFRSF10C 18.62822766 27.40381115 9.852644165 0.359535545 -1.475793689 0.200532217 1 0.994914953 0.373115869 8794 TNF receptor superfamily member 10c "GO:0004888,GO:0005515,GO:0005886,GO:0009986,GO:0031225,GO:0036462,GO:0042981,GO:0043065,GO:0045569" transmembrane signaling receptor activity|protein binding|plasma membrane|cell surface|anchored component of membrane|TRAIL-activated apoptotic signaling pathway|regulation of apoptotic process|positive regulation of apoptotic process|TRAIL binding "hsa04060,hsa04061" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor TNFRSF10D 457.3660786 620.1380967 294.5940605 0.4750459 -1.073861177 0.010773637 0.442502635 8.884810999 4.40250338 8793 TNF receptor superfamily member 10d "GO:0004888,GO:0005515,GO:0005886,GO:0006915,GO:0007165,GO:0007166,GO:0009986,GO:0016021,GO:0042981,GO:0043066,GO:0045569,GO:0050900" transmembrane signaling receptor activity|protein binding|plasma membrane|apoptotic process|signal transduction|cell surface receptor signaling pathway|cell surface|integral component of membrane|regulation of apoptotic process|negative regulation of apoptotic process|TRAIL binding|leukocyte migration "hsa04060,hsa04061" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor TNFRSF11A 55.78076254 75.10674166 36.45478341 0.485372985 -1.042834281 0.204931712 1 0.711140681 0.360036933 8792 TNF receptor superfamily member 11a "GO:0001503,GO:0002250,GO:0002548,GO:0004888,GO:0005031,GO:0005515,GO:0005829,GO:0005886,GO:0007165,GO:0007267,GO:0008284,GO:0009314,GO:0009897,GO:0016021,GO:0019955,GO:0030316,GO:0032496,GO:0033209,GO:0034097,GO:0034612,GO:0038023,GO:0043507,GO:0045780,GO:0046872,GO:0048535,GO:0051091,GO:0051092,GO:0060086,GO:0060749,GO:0070555,GO:0071812,GO:0071847,GO:0071848,GO:0072674" ossification|adaptive immune response|monocyte chemotaxis|transmembrane signaling receptor activity|tumor necrosis factor-activated receptor activity|protein binding|cytosol|plasma membrane|signal transduction|cell-cell signaling|positive regulation of cell population proliferation|response to radiation|external side of plasma membrane|integral component of membrane|cytokine binding|osteoclast differentiation|response to lipopolysaccharide|tumor necrosis factor-mediated signaling pathway|response to cytokine|response to tumor necrosis factor|signaling receptor activity|positive regulation of JUN kinase activity|positive regulation of bone resorption|metal ion binding|lymph node development|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|circadian temperature homeostasis|mammary gland alveolus development|response to interleukin-1|positive regulation of fever generation by positive regulation of prostaglandin secretion|TNFSF11-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|multinuclear osteoclast differentiation "hsa04060,hsa04064,hsa04380,hsa04917,hsa05323" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Osteoclast differentiation|Prolactin signaling pathway|Rheumatoid arthritis TNFRSF11B 6313.628589 5762.919988 6864.33719 1.191121377 0.252320433 0.438150065 1 139.8522123 173.7565918 4982 TNF receptor superfamily member 11b "GO:0001501,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0006915,GO:0007165,GO:0007584,GO:0030198,GO:0031012,GO:0032026,GO:0033209,GO:0038023,GO:0042489,GO:0042493,GO:0043627,GO:0045779,GO:0046685" skeletal system development|cytokine activity|protein binding|extracellular region|extracellular space|plasma membrane|apoptotic process|signal transduction|response to nutrient|extracellular matrix organization|extracellular matrix|response to magnesium ion|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|negative regulation of odontogenesis of dentin-containing tooth|response to drug|response to estrogen|negative regulation of bone resorption|response to arsenic-containing substance "hsa04060,hsa04380" Cytokine-cytokine receptor interaction|Osteoclast differentiation TNFRSF12A 3508.291046 3082.421276 3934.160815 1.276321587 0.351991882 0.26875534 1 159.7889084 212.7270288 51330 TNF receptor superfamily member 12A "GO:0001525,GO:0005515,GO:0005886,GO:0006915,GO:0007155,GO:0016021,GO:0030154,GO:0033209,GO:0043065,GO:0061041,GO:2001238" angiogenesis|protein binding|plasma membrane|apoptotic process|cell adhesion|integral component of membrane|cell differentiation|tumor necrosis factor-mediated signaling pathway|positive regulation of apoptotic process|regulation of wound healing|positive regulation of extrinsic apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFRSF13C 24.4507395 21.31407534 27.58740366 1.294327961 0.372203218 0.750099954 1 0.275167658 0.371499002 115650 TNF receptor superfamily member 13C "GO:0002250,GO:0005886,GO:0009897,GO:0016021,GO:0030890,GO:0031295,GO:0031296,GO:0033209,GO:0038023,GO:0042102" adaptive immune response|plasma membrane|external side of plasma membrane|integral component of membrane|positive regulation of B cell proliferation|T cell costimulation|B cell costimulation|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|positive regulation of T cell proliferation "hsa04060,hsa04064,hsa04672,hsa05166,hsa05340" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Primary immunodeficiency TNFRSF14 158.4830727 124.8395841 192.1265612 1.538987514 0.621981527 0.285918634 1 2.132439976 3.423165067 8764 TNF receptor superfamily member 14 "GO:0001618,GO:0002250,GO:0002720,GO:0005031,GO:0005515,GO:0005886,GO:0006955,GO:0007166,GO:0009897,GO:0016021,GO:0019955,GO:0031295,GO:0031625,GO:0033209,GO:0045087,GO:0046642,GO:0046718,GO:0050731,GO:0050829,GO:0050830,GO:1905675,GO:2000406" virus receptor activity|adaptive immune response|positive regulation of cytokine production involved in immune response|tumor necrosis factor-activated receptor activity|protein binding|plasma membrane|immune response|cell surface receptor signaling pathway|external side of plasma membrane|integral component of membrane|cytokine binding|T cell costimulation|ubiquitin protein ligase binding|tumor necrosis factor-mediated signaling pathway|innate immune response|negative regulation of alpha-beta T cell proliferation|viral entry into host cell|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|negative regulation of adaptive immune memory response|positive regulation of T cell migration "hsa04060,hsa04061,hsa05168" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Herpes simplex virus 1 infection TNFRSF19 65.85881494 56.83753423 74.88009566 1.31744096 0.39773831 0.618140343 1 0.468754372 0.644158027 55504 TNF receptor superfamily member 19 "GO:0001942,GO:0005031,GO:0005515,GO:0005886,GO:0006915,GO:0007254,GO:0016021,GO:0033209,GO:0038023,GO:0043123,GO:0046330" hair follicle development|tumor necrosis factor-activated receptor activity|protein binding|plasma membrane|apoptotic process|JNK cascade|integral component of membrane|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade hsa04060 Cytokine-cytokine receptor interaction TNFRSF1A 1828.029963 1944.655635 1711.404292 0.880055194 -0.184334088 0.57059682 1 43.02750004 39.49771335 7132 TNF receptor superfamily member 1A "GO:0000139,GO:0002947,GO:0003176,GO:0003177,GO:0003332,GO:0005031,GO:0005515,GO:0005576,GO:0005615,GO:0005739,GO:0005886,GO:0005887,GO:0006693,GO:0006954,GO:0007249,GO:0008625,GO:0008630,GO:0009986,GO:0010614,GO:0010803,GO:0016020,GO:0016032,GO:0019221,GO:0033209,GO:0042531,GO:0042742,GO:0043120,GO:0043123,GO:0043235,GO:0045121,GO:0045944,GO:0050728,GO:0050729,GO:0071260,GO:0071550,GO:0072659,GO:1902339,GO:1903140,GO:2000304" Golgi membrane|tumor necrosis factor receptor superfamily complex|aortic valve development|pulmonary valve development|negative regulation of extracellular matrix constituent secretion|tumor necrosis factor-activated receptor activity|protein binding|extracellular region|extracellular space|mitochondrion|plasma membrane|integral component of plasma membrane|prostaglandin metabolic process|inflammatory response|I-kappaB kinase/NF-kappaB signaling|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|cell surface|negative regulation of cardiac muscle hypertrophy|regulation of tumor necrosis factor-mediated signaling pathway|membrane|viral process|cytokine-mediated signaling pathway|tumor necrosis factor-mediated signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|defense response to bacterium|tumor necrosis factor binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|membrane raft|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|positive regulation of inflammatory response|cellular response to mechanical stimulus|death-inducing signaling complex assembly|protein localization to plasma membrane|positive regulation of apoptotic process involved in morphogenesis|regulation of establishment of endothelial barrier|positive regulation of ceramide biosynthetic process "hsa04010,hsa04060,hsa04061,hsa04064,hsa04071,hsa04150,hsa04210,hsa04215,hsa04217,hsa04380,hsa04668,hsa04920,hsa04931,hsa04932,hsa05010,hsa05014,hsa05022,hsa05130,hsa05131,hsa05132,hsa05142,hsa05145,hsa05152,hsa05160,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05170,hsa05171,hsa05418" MAPK signaling pathway|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NF-kappa B signaling pathway|Sphingolipid signaling pathway|mTOR signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Osteoclast differentiation|TNF signaling pathway|Adipocytokine signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Alzheimer disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Fluid shear stress and atherosclerosis TNFRSF1B 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.040571381 0.041081029 7133 TNF receptor superfamily member 1B "GO:0002718,GO:0002724,GO:0002947,GO:0003176,GO:0003177,GO:0003332,GO:0005031,GO:0005515,GO:0005576,GO:0005634,GO:0005886,GO:0006954,GO:0007568,GO:0008630,GO:0010614,GO:0016020,GO:0016021,GO:0019221,GO:0031625,GO:0031641,GO:0031643,GO:0033209,GO:0035579,GO:0042129,GO:0043025,GO:0043120,GO:0043196,GO:0043312,GO:0045121,GO:0048471,GO:0048714,GO:0050779,GO:0051044,GO:0060548,GO:0071222,GO:0071363,GO:0097191,GO:0150077,GO:0150079,GO:0150098,GO:1901215,GO:1902339,GO:2001141" regulation of cytokine production involved in immune response|regulation of T cell cytokine production|tumor necrosis factor receptor superfamily complex|aortic valve development|pulmonary valve development|negative regulation of extracellular matrix constituent secretion|tumor necrosis factor-activated receptor activity|protein binding|extracellular region|nucleus|plasma membrane|inflammatory response|aging|intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of cardiac muscle hypertrophy|membrane|integral component of membrane|cytokine-mediated signaling pathway|ubiquitin protein ligase binding|regulation of myelination|positive regulation of myelination|tumor necrosis factor-mediated signaling pathway|specific granule membrane|regulation of T cell proliferation|neuronal cell body|tumor necrosis factor binding|varicosity|neutrophil degranulation|membrane raft|perinuclear region of cytoplasm|positive regulation of oligodendrocyte differentiation|RNA destabilization|positive regulation of membrane protein ectodomain proteolysis|negative regulation of cell death|cellular response to lipopolysaccharide|cellular response to growth factor stimulus|extrinsic apoptotic signaling pathway|regulation of neuroinflammatory response|negative regulation of neuroinflammatory response|glial cell-neuron signaling|negative regulation of neuron death|positive regulation of apoptotic process involved in morphogenesis|regulation of RNA biosynthetic process "hsa04060,hsa04061,hsa04668,hsa04920,hsa05014,hsa05022,hsa05170" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|TNF signaling pathway|Adipocytokine signaling pathway|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Human immunodeficiency virus 1 infection TNFRSF21 2939.132098 3138.243854 2740.020342 0.873106256 -0.195770856 0.538636759 1 42.57727837 38.7758143 27242 TNF receptor superfamily member 21 "GO:0001783,GO:0002250,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006915,GO:0006959,GO:0007413,GO:0016032,GO:0019216,GO:0030424,GO:0030889,GO:0031226,GO:0031642,GO:0032693,GO:0032696,GO:0032714,GO:0042130,GO:0042552,GO:0048713,GO:0050852,GO:0051402,GO:0071356,GO:0097252" B cell apoptotic process|adaptive immune response|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|apoptotic process|humoral immune response|axonal fasciculation|viral process|regulation of lipid metabolic process|axon|negative regulation of B cell proliferation|intrinsic component of plasma membrane|negative regulation of myelination|negative regulation of interleukin-10 production|negative regulation of interleukin-13 production|negative regulation of interleukin-5 production|negative regulation of T cell proliferation|myelination|regulation of oligodendrocyte differentiation|T cell receptor signaling pathway|neuron apoptotic process|cellular response to tumor necrosis factor|oligodendrocyte apoptotic process hsa04060 Cytokine-cytokine receptor interaction TNFRSF25 295.1121789 237.4996966 352.7246611 1.485158365 0.570616776 0.230374023 1 5.324710838 8.248685085 8718 TNF receptor superfamily member 25 "GO:0005031,GO:0005576,GO:0005829,GO:0005886,GO:0005887,GO:0006915,GO:0007165,GO:0007166,GO:0033209,GO:0038023,GO:0042981,GO:0097190" tumor necrosis factor-activated receptor activity|extracellular region|cytosol|plasma membrane|integral component of plasma membrane|apoptotic process|signal transduction|cell surface receptor signaling pathway|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|regulation of apoptotic process|apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFRSF4 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.078479297 0.019866284 7293 TNF receptor superfamily member 4 "GO:0001618,GO:0002639,GO:0005031,GO:0005515,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0009897,GO:0009986,GO:0030890,GO:0033209,GO:0042098,GO:0043433,GO:0045892,GO:0046718" "virus receptor activity|positive regulation of immunoglobulin production|tumor necrosis factor-activated receptor activity|protein binding|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|external side of plasma membrane|cell surface|positive regulation of B cell proliferation|tumor necrosis factor-mediated signaling pathway|T cell proliferation|negative regulation of DNA-binding transcription factor activity|negative regulation of transcription, DNA-templated|viral entry into host cell" hsa04060 Cytokine-cytokine receptor interaction TNFRSF6B 3707.165508 3813.189573 3601.141442 0.944390876 -0.082543991 0.795958568 1 169.4075436 166.8785271 8771 TNF receptor superfamily member 6b "GO:0005515,GO:0005576,GO:0005615,GO:0006915,GO:0033209,GO:0038023,GO:0043066" protein binding|extracellular region|extracellular space|apoptotic process|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|negative regulation of apoptotic process hsa04060 Cytokine-cytokine receptor interaction TNFRSF9 156.1129456 265.9184637 46.30742758 0.174141453 -2.521668431 4.82E-05 0.008715627 1.960383127 0.356089402 3604 TNF receptor superfamily member 9 "GO:0005515,GO:0005886,GO:0005887,GO:0006915,GO:0008285,GO:0009897,GO:0019955,GO:0033209,GO:0038023,GO:0042127" protein binding|plasma membrane|integral component of plasma membrane|apoptotic process|negative regulation of cell population proliferation|external side of plasma membrane|cytokine binding|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|regulation of cell population proliferation hsa04060 Cytokine-cytokine receptor interaction TNFSF10 18.1059039 25.37389921 10.83790858 0.427128227 -1.227258852 0.291285665 1 0.430230493 0.191679378 8743 TNF superfamily member 10 "GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005887,GO:0006915,GO:0006919,GO:0006955,GO:0007165,GO:0007166,GO:0007267,GO:0008270,GO:0008584,GO:0032868,GO:0042802,GO:0043065,GO:0043123,GO:0043280,GO:0045569,GO:0070062,GO:0090200,GO:1902041,GO:1902042,GO:2001238" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular region|integral component of plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|immune response|signal transduction|cell surface receptor signaling pathway|cell-cell signaling|zinc ion binding|male gonad development|response to insulin|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|TRAIL binding|extracellular exosome|positive regulation of release of cytochrome c from mitochondria|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of extrinsic apoptotic signaling pathway "hsa04060,hsa04061,hsa04068,hsa04210,hsa04217,hsa04650,hsa05130,hsa05132,hsa05164" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|FoxO signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|Pathogenic Escherichia coli infection|Salmonella infection|Influenza A TNFSF12 149.4226978 111.6451565 187.2002391 1.67674304 0.745661614 0.209515137 1 4.106342278 7.181870809 8742 TNF superfamily member 12 "GO:0001525,GO:0001938,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0005887,GO:0006915,GO:0006955,GO:0007165,GO:0030154,GO:0033209,GO:0043542,GO:0045732,GO:0045766,GO:0048471,GO:0097191,GO:2001238" angiogenesis|positive regulation of endothelial cell proliferation|signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular region|extracellular space|plasma membrane|integral component of plasma membrane|apoptotic process|immune response|signal transduction|cell differentiation|tumor necrosis factor-mediated signaling pathway|endothelial cell migration|positive regulation of protein catabolic process|positive regulation of angiogenesis|perinuclear region of cytoplasm|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFSF13 17.56873436 22.3290313 12.80843742 0.573622619 -0.801826182 0.504377076 1 0.593641293 0.355194555 8741 TNF superfamily member 13 "GO:0005102,GO:0005125,GO:0005164,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006955,GO:0007165,GO:0008284,GO:0033209,GO:0043488,GO:0048298,GO:0070062" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|extracellular region|extracellular space|nucleoplasm|cytoplasm|cytosol|plasma membrane|immune response|signal transduction|positive regulation of cell population proliferation|tumor necrosis factor-mediated signaling pathway|regulation of mRNA stability|positive regulation of isotype switching to IgA isotypes|extracellular exosome "hsa04060,hsa04672,hsa05323" Cytokine-cytokine receptor interaction|Intestinal immune network for IgA production|Rheumatoid arthritis TNFSF13B 4.537610306 7.104691779 1.970528833 0.277355992 -1.850189203 0.383956367 1 0.135019728 0.039061661 10673 TNF superfamily member 13b "GO:0001782,GO:0002636,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0005925,GO:0006955,GO:0007165,GO:0016021,GO:0030890,GO:0031295,GO:0031296,GO:0033209,GO:0042102,GO:0043231,GO:0048471" B cell homeostasis|positive regulation of germinal center formation|signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|plasma membrane|focal adhesion|immune response|signal transduction|integral component of membrane|positive regulation of B cell proliferation|T cell costimulation|B cell costimulation|tumor necrosis factor-mediated signaling pathway|positive regulation of T cell proliferation|intracellular membrane-bounded organelle|perinuclear region of cytoplasm "hsa04060,hsa04064,hsa04672,hsa05323" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Intestinal immune network for IgA production|Rheumatoid arthritis TNFSF14 4.537610306 7.104691779 1.970528833 0.277355992 -1.850189203 0.383956367 1 0.065878355 0.01905883 8740 TNF superfamily member 14 "GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005737,GO:0005886,GO:0006915,GO:0006955,GO:0007165,GO:0016021,GO:0031295,GO:0033209,GO:0042098,GO:0042110,GO:0043027,GO:0043029,GO:0043154,GO:0071260,GO:1901224" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular space|cytoplasm|plasma membrane|apoptotic process|immune response|signal transduction|integral component of membrane|T cell costimulation|tumor necrosis factor-mediated signaling pathway|T cell proliferation|T cell activation|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|T cell homeostasis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to mechanical stimulus|positive regulation of NIK/NF-kappaB signaling "hsa04060,hsa04061,hsa04064,hsa05168" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NF-kappa B signaling pathway|Herpes simplex virus 1 infection TNFSF15 80.36511402 105.5554207 55.17480733 0.522709369 -0.935919077 0.200097462 1 0.810001467 0.44163351 9966 TNF superfamily member 15 "GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006915,GO:0006919,GO:0006955,GO:0007165,GO:0007250,GO:0016021,GO:0033209" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|immune response|signal transduction|activation of NF-kappaB-inducing kinase activity|integral component of membrane|tumor necrosis factor-mediated signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFSF4 17.39058505 10.14955968 24.63161041 2.426864926 1.279093814 0.278569788 1 0.039574978 0.100180275 7292 TNF superfamily member 4 "GO:0001819,GO:0002215,GO:0002526,GO:0002639,GO:0002726,GO:0002819,GO:0002830,GO:0002891,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0008284,GO:0009615,GO:0009986,GO:0032689,GO:0032700,GO:0032729,GO:0032733,GO:0032735,GO:0032736,GO:0032753,GO:0032755,GO:0032813,GO:0033209,GO:0035709,GO:0035712,GO:0035713,GO:0042102,GO:0043372,GO:0043382,GO:0043433,GO:0045590,GO:0045626,GO:0045630,GO:0045892,GO:0046641,GO:0050727,GO:0050729,GO:0050871,GO:0071222,GO:0071380,GO:0071954,GO:1900281,GO:2000572" "positive regulation of cytokine production|defense response to nematode|acute inflammatory response|positive regulation of immunoglobulin production|positive regulation of T cell cytokine production|regulation of adaptive immune response|positive regulation of type 2 immune response|positive regulation of immunoglobulin mediated immune response|signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|positive regulation of cell population proliferation|response to virus|cell surface|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|tumor necrosis factor receptor superfamily binding|tumor necrosis factor-mediated signaling pathway|memory T cell activation|T-helper 2 cell activation|response to nitrogen dioxide|positive regulation of T cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of memory T cell differentiation|negative regulation of DNA-binding transcription factor activity|negative regulation of regulatory T cell differentiation|negative regulation of T-helper 1 cell differentiation|positive regulation of T-helper 2 cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of alpha-beta T cell proliferation|regulation of inflammatory response|positive regulation of inflammatory response|positive regulation of B cell activation|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|positive regulation of CD4-positive, alpha-beta T cell costimulation|positive regulation of interleukin-4-dependent isotype switching to IgE isotypes" hsa04060 Cytokine-cytokine receptor interaction TNFSF8 2.463161041 0 4.926322083 Inf Inf 0.189235799 1 0 0.055561127 944 TNF superfamily member 8 "GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006955,GO:0007267,GO:0033209,GO:0042129,GO:0043374,GO:0045944,GO:0050830" "signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|immune response|cell-cell signaling|tumor necrosis factor-mediated signaling pathway|regulation of T cell proliferation|CD8-positive, alpha-beta T cell differentiation|positive regulation of transcription by RNA polymerase II|defense response to Gram-positive bacterium" hsa04060 Cytokine-cytokine receptor interaction TNFSF9 137.3417034 161.377999 113.3054079 0.702111865 -0.510227186 0.40488301 1 5.001974505 3.663226026 8744 TNF superfamily member 9 "GO:0005102,GO:0005125,GO:0005164,GO:0005615,GO:0005886,GO:0006955,GO:0007267,GO:0016021,GO:0032813,GO:0033209,GO:0042104,GO:0042129,GO:0042981,GO:0045585" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|extracellular space|plasma membrane|immune response|cell-cell signaling|integral component of membrane|tumor necrosis factor receptor superfamily binding|tumor necrosis factor-mediated signaling pathway|positive regulation of activated T cell proliferation|regulation of T cell proliferation|regulation of apoptotic process|positive regulation of cytotoxic T cell differentiation hsa04060 Cytokine-cytokine receptor interaction TNIK 429.8449851 355.2345889 504.4553813 1.420062677 0.505954607 0.234212166 1 1.818780705 2.694038396 23043 TRAF2 and NCK interacting kinase "GO:0000165,GO:0001934,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0007010,GO:0007165,GO:0007256,GO:0016055,GO:0016324,GO:0030033,GO:0031098,GO:0031532,GO:0032147,GO:0035556,GO:0046777,GO:0048812,GO:0048814,GO:0055037,GO:0070062,GO:0072659,GO:0098793,GO:0098978,GO:0099092,GO:0106310,GO:0106311" "MAPK cascade|positive regulation of protein phosphorylation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|cytoskeleton organization|signal transduction|activation of JNKK activity|Wnt signaling pathway|apical plasma membrane|microvillus assembly|stress-activated protein kinase signaling cascade|actin cytoskeleton reorganization|activation of protein kinase activity|intracellular signal transduction|protein autophosphorylation|neuron projection morphogenesis|regulation of dendrite morphogenesis|recycling endosome|extracellular exosome|protein localization to plasma membrane|presynapse|glutamatergic synapse|postsynaptic density, intracellular component|protein serine kinase activity|protein threonine kinase activity" TNIP1 8197.978222 9234.0694 7161.887044 0.775593807 -0.36662681 0.26861909 1 130.4163523 105.5072519 10318 TNFAIP3 interacting protein 1 "GO:0002755,GO:0005515,GO:0005654,GO:0005829,GO:0006412,GO:0006952,GO:0006954,GO:0007159,GO:0009101,GO:0016579,GO:0031593,GO:0042802,GO:0043124,GO:0045071,GO:0045944,GO:0050729,GO:0051019,GO:0070373,GO:0085032,GO:1903003" MyD88-dependent toll-like receptor signaling pathway|protein binding|nucleoplasm|cytosol|translation|defense response|inflammatory response|leukocyte cell-cell adhesion|glycoprotein biosynthetic process|protein deubiquitination|polyubiquitin modification-dependent protein binding|identical protein binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|positive regulation of transcription by RNA polymerase II|positive regulation of inflammatory response|mitogen-activated protein kinase binding|negative regulation of ERK1 and ERK2 cascade|modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|positive regulation of protein deubiquitination hsa05131 Shigellosis TNIP2 493.0840164 502.4032043 483.7648285 0.962901559 -0.054539782 0.898993945 1 12.6528841 12.70829681 79155 TNFAIP3 interacting protein 2 "GO:0005515,GO:0005654,GO:0005829,GO:0006915,GO:0006954,GO:0016579,GO:0019901,GO:0023035,GO:0031593,GO:0034134,GO:0034138,GO:0034162,GO:0043032,GO:0043123,GO:0045944,GO:0046872,GO:0050821,GO:0050871,GO:0051403,GO:0070498,GO:0070530,GO:0071222,GO:2000352" protein binding|nucleoplasm|cytosol|apoptotic process|inflammatory response|protein deubiquitination|protein kinase binding|CD40 signaling pathway|polyubiquitin modification-dependent protein binding|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 9 signaling pathway|positive regulation of macrophage activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription by RNA polymerase II|metal ion binding|protein stabilization|positive regulation of B cell activation|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|cellular response to lipopolysaccharide|negative regulation of endothelial cell apoptotic process TNIP3 5.522874722 7.104691779 3.941057666 0.554711983 -0.850189203 0.698446051 1 0.083680831 0.048418292 79931 TNFAIP3 interacting protein 3 "GO:0002756,GO:0005515,GO:0005829,GO:0006954,GO:0016579,GO:0031593,GO:0034142,GO:0043124,GO:0045944,GO:0071222" MyD88-independent toll-like receptor signaling pathway|protein binding|cytosol|inflammatory response|protein deubiquitination|polyubiquitin modification-dependent protein binding|toll-like receptor 4 signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription by RNA polymerase II|cellular response to lipopolysaccharide TNK1 181.2898904 168.4826908 194.0970901 1.152029857 0.204178107 0.720189185 1 2.816189411 3.384087046 8711 tyrosine kinase non receptor 1 "GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0007169,GO:0016020,GO:0030154,GO:0031234,GO:0038083,GO:0042127,GO:0045087,GO:0046777" protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|cytoplasm|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|membrane|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|innate immune response|protein autophosphorylation TNK2 647.9217092 479.0592171 816.7842013 1.704975444 0.769750961 0.045710535 0.966026298 3.94578945 7.017266419 10188 tyrosine kinase non receptor 2 "GO:0004712,GO:0004713,GO:0004715,GO:0005095,GO:0005102,GO:0005154,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0005905,GO:0005912,GO:0006897,GO:0007166,GO:0007169,GO:0007264,GO:0016020,GO:0016310,GO:0030136,GO:0030154,GO:0030659,GO:0031234,GO:0031625,GO:0034260,GO:0038083,GO:0042127,GO:0042802,GO:0045087,GO:0046872,GO:0048471,GO:0050699,GO:0050731,GO:0070436,GO:0097268,GO:0106310,GO:0106311,GO:2000369" protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|GTPase inhibitor activity|signaling receptor binding|epidermal growth factor receptor binding|protein binding|ATP binding|nucleus|cytoplasm|endosome|cytosol|plasma membrane|clathrin-coated pit|adherens junction|endocytosis|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|small GTPase mediated signal transduction|membrane|phosphorylation|clathrin-coated vesicle|cell differentiation|cytoplasmic vesicle membrane|extrinsic component of cytoplasmic side of plasma membrane|ubiquitin protein ligase binding|negative regulation of GTPase activity|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|identical protein binding|innate immune response|metal ion binding|perinuclear region of cytoplasm|WW domain binding|positive regulation of peptidyl-tyrosine phosphorylation|Grb2-EGFR complex|cytoophidium|protein serine kinase activity|protein threonine kinase activity|regulation of clathrin-dependent endocytosis TNKS 1515.109042 1331.622231 1698.595854 1.275583882 0.351157773 0.289050609 1 4.853336809 6.457514409 8658 tankyrase "GO:0000139,GO:0000209,GO:0000242,GO:0000781,GO:0003950,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006471,GO:0007052,GO:0008270,GO:0015031,GO:0016055,GO:0016604,GO:0018105,GO:0018107,GO:0031670,GO:0031965,GO:0032210,GO:0032212,GO:0042393,GO:0045944,GO:0051028,GO:0051225,GO:0051301,GO:0051973,GO:0070198,GO:0070212,GO:0070213,GO:0090263,GO:0097431,GO:1904355,GO:1904357,GO:1904743,GO:1904908,GO:1990404" "Golgi membrane|protein polyubiquitination|pericentriolar material|chromosome, telomeric region|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|protein ADP-ribosylation|mitotic spindle organization|zinc ion binding|protein transport|Wnt signaling pathway|nuclear body|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cellular response to nutrient|nuclear membrane|regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|histone binding|positive regulation of transcription by RNA polymerase II|mRNA transport|spindle assembly|cell division|positive regulation of telomerase activity|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|positive regulation of canonical Wnt signaling pathway|mitotic spindle pole|positive regulation of telomere capping|negative regulation of telomere maintenance via telomere lengthening|negative regulation of telomeric DNA binding|negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric|protein ADP-ribosylase activity" TNKS1BP1 3053.250065 3059.077289 3047.42284 0.996190208 -0.005506865 0.987344769 1 24.98088889 25.95769265 85456 tankyrase 1 binding protein 1 "GO:0000289,GO:0000792,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0006302,GO:0006977,GO:0007004,GO:0010800,GO:0015629,GO:0019899,GO:0030014,GO:0031954,GO:0033138,GO:0044877,GO:0045296,GO:0071479,GO:0071532" "nuclear-transcribed mRNA poly(A) tail shortening|heterochromatin|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|adherens junction|double-strand break repair|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|telomere maintenance via telomerase|positive regulation of peptidyl-threonine phosphorylation|actin cytoskeleton|enzyme binding|CCR4-NOT complex|positive regulation of protein autophosphorylation|positive regulation of peptidyl-serine phosphorylation|protein-containing complex binding|cadherin binding|cellular response to ionizing radiation|ankyrin repeat binding" TNKS2 4918.585226 4826.11563 5011.054823 1.038320506 0.05425184 0.866246067 1 29.2305347 31.65804707 80351 tankyrase 2 "GO:0000139,GO:0000209,GO:0000242,GO:0000781,GO:0003950,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0006471,GO:0016055,GO:0019899,GO:0032212,GO:0035264,GO:0040014,GO:0046872,GO:0048471,GO:0070198,GO:0070212,GO:0070213,GO:0090263,GO:1904355,GO:1904357,GO:1990404" "Golgi membrane|protein polyubiquitination|pericentriolar material|chromosome, telomeric region|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|nuclear envelope|cytoplasm|cytosol|protein ADP-ribosylation|Wnt signaling pathway|enzyme binding|positive regulation of telomere maintenance via telomerase|multicellular organism growth|regulation of multicellular organism growth|metal ion binding|perinuclear region of cytoplasm|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|positive regulation of canonical Wnt signaling pathway|positive regulation of telomere capping|negative regulation of telomere maintenance via telomere lengthening|protein ADP-ribosylase activity" TNNC1 6.522984915 8.119647747 4.926322083 0.606716232 -0.720906186 0.726457076 1 0.598590268 0.378818513 7134 "troponin C1, slow skeletal and cardiac type" "GO:0002086,GO:0003009,GO:0005509,GO:0005515,GO:0005829,GO:0005861,GO:0006937,GO:0010038,GO:0014883,GO:0030049,GO:0031013,GO:0031014,GO:0032972,GO:0042803,GO:0043462,GO:0048306,GO:0051015,GO:0055010,GO:0060048,GO:1990584" diaphragm contraction|skeletal muscle contraction|calcium ion binding|protein binding|cytosol|troponin complex|regulation of muscle contraction|response to metal ion|transition between fast and slow fiber|muscle filament sliding|troponin I binding|troponin T binding|regulation of muscle filament sliding speed|protein homodimerization activity|regulation of ATPase activity|calcium-dependent protein binding|actin filament binding|ventricular cardiac muscle tissue morphogenesis|cardiac muscle contraction|cardiac Troponin complex "hsa04020,hsa04260,hsa04261,hsa05410,hsa05414" Calcium signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TNNC2 4.537610306 7.104691779 1.970528833 0.277355992 -1.850189203 0.383956367 1 0.473457335 0.136972799 7125 "troponin C2, fast skeletal type" "GO:0003009,GO:0003779,GO:0005509,GO:0005515,GO:0005829,GO:0005861,GO:0006937,GO:0030049,GO:0048306,GO:0051015" skeletal muscle contraction|actin binding|calcium ion binding|protein binding|cytosol|troponin complex|regulation of muscle contraction|muscle filament sliding|calcium-dependent protein binding|actin filament binding hsa04020 Calcium signaling pathway TNNI3 9.060374836 13.19442759 4.926322083 0.373363835 -1.421345905 0.34429886 1 0.792706062 0.308716867 7137 "troponin I3, cardiac type" "GO:0001570,GO:0001980,GO:0003009,GO:0003779,GO:0005515,GO:0005829,GO:0005861,GO:0006874,GO:0006936,GO:0007507,GO:0010882,GO:0019855,GO:0019901,GO:0019904,GO:0030017,GO:0030049,GO:0030172,GO:0031014,GO:0032780,GO:0046872,GO:0048306,GO:0051015,GO:0055010,GO:0060047,GO:0060048,GO:0097512,GO:1990584" vasculogenesis|regulation of systemic arterial blood pressure by ischemic conditions|skeletal muscle contraction|actin binding|protein binding|cytosol|troponin complex|cellular calcium ion homeostasis|muscle contraction|heart development|regulation of cardiac muscle contraction by calcium ion signaling|calcium channel inhibitor activity|protein kinase binding|protein domain specific binding|sarcomere|muscle filament sliding|troponin C binding|troponin T binding|negative regulation of ATPase activity|metal ion binding|calcium-dependent protein binding|actin filament binding|ventricular cardiac muscle tissue morphogenesis|heart contraction|cardiac muscle contraction|cardiac myofibril|cardiac Troponin complex "hsa04024,hsa04260,hsa04261,hsa05410,hsa05414" cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TNNT1 1247.449171 1286.964168 1207.934175 0.938591924 -0.091430048 0.789760632 1 53.646251 52.52089523 7138 "troponin T1, slow skeletal type" "GO:0003009,GO:0005515,GO:0005523,GO:0005829,GO:0005861,GO:0006936,GO:0014883,GO:0030049,GO:0031014,GO:0031444,GO:0045214,GO:0045932" skeletal muscle contraction|protein binding|tropomyosin binding|cytosol|troponin complex|muscle contraction|transition between fast and slow fiber|muscle filament sliding|troponin T binding|slow-twitch skeletal muscle fiber contraction|sarcomere organization|negative regulation of muscle contraction TNPO1 5051.425938 4713.455517 5389.396359 1.143406645 0.19333858 0.54741559 1 24.52937668 29.25520556 3842 transportin 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005929,GO:0006606,GO:0008139,GO:0016032,GO:0035735,GO:0043488,GO:0061608,GO:0070062" RNA binding|protein binding|nucleus|cytoplasm|cytosol|cilium|protein import into nucleus|nuclear localization sequence binding|viral process|intraciliary transport involved in cilium assembly|regulation of mRNA stability|nuclear import signal receptor activity|extracellular exosome TNPO2 2822.301561 2796.203693 2848.399428 1.018666643 0.026682009 0.934326402 1 26.91842856 28.60208663 30000 transportin 2 "GO:0005515,GO:0005634,GO:0005737,GO:0006606,GO:0008139,GO:0061608" protein binding|nucleus|cytoplasm|protein import into nucleus|nuclear localization sequence binding|nuclear import signal receptor activity TNPO3 2496.565275 2452.13362 2540.99693 1.03623918 0.051357037 0.873225716 1 28.05962884 30.32898389 23534 transportin 3 "GO:0005515,GO:0005635,GO:0005642,GO:0005737,GO:0006606,GO:0031267,GO:0042802,GO:0043231,GO:0061608" protein binding|nuclear envelope|annulate lamellae|cytoplasm|protein import into nucleus|small GTPase binding|identical protein binding|intracellular membrane-bounded organelle|nuclear import signal receptor activity TNRC18 4209.341321 3758.381951 4660.30069 1.239975274 0.310311353 0.330993803 1 13.67055351 17.68133506 84629 trinucleotide repeat containing 18 "GO:0003682,GO:0005654,GO:0005739,GO:0005829,GO:0031965" chromatin binding|nucleoplasm|mitochondrion|cytosol|nuclear membrane TNRC6A 1380.643214 1602.615474 1158.670954 0.722987499 -0.467957392 0.16283784 1 10.64203751 8.025488989 27327 trinucleotide repeat containing adaptor 6A "GO:0000932,GO:0003723,GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0007223,GO:0009267,GO:0010628,GO:0010629,GO:0016442,GO:0035194,GO:0035195,GO:0035278,GO:0043231,GO:0045652,GO:0060213,GO:0060964" "P-body|RNA binding|protein binding|nucleoplasm|Golgi apparatus|cytosol|Wnt signaling pathway, calcium modulating pathway|cellular response to starvation|positive regulation of gene expression|negative regulation of gene expression|RISC complex|post-transcriptional gene silencing by RNA|gene silencing by miRNA|miRNA mediated inhibition of translation|intracellular membrane-bounded organelle|regulation of megakaryocyte differentiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of gene silencing by miRNA" TNRC6B 1165.912479 1269.709916 1062.115041 0.836502123 -0.257558893 0.453907045 1 3.44289153 3.004044195 23112 trinucleotide repeat containing adaptor 6B "GO:0000932,GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0007223,GO:0010628,GO:0010629,GO:0031047,GO:0035194,GO:0035195,GO:0035278,GO:0045652,GO:0060213,GO:1900153,GO:1905618" "P-body|RNA binding|protein binding|nucleoplasm|cytosol|Wnt signaling pathway, calcium modulating pathway|positive regulation of gene expression|negative regulation of gene expression|gene silencing by RNA|post-transcriptional gene silencing by RNA|gene silencing by miRNA|miRNA mediated inhibition of translation|regulation of megakaryocyte differentiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of miRNA mediated inhibition of translation" TNRC6C 251.2409424 201.9762377 300.505647 1.487826739 0.573206531 0.252611904 1 0.77430807 1.2016613 57690 trinucleotide repeat containing adaptor 6C "GO:0000932,GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0007223,GO:0010628,GO:0010629,GO:0035194,GO:0035195,GO:0035278,GO:0045652,GO:0060213,GO:1900153" "P-body|RNA binding|protein binding|nucleoplasm|cytosol|Wnt signaling pathway, calcium modulating pathway|positive regulation of gene expression|negative regulation of gene expression|post-transcriptional gene silencing by RNA|gene silencing by miRNA|miRNA mediated inhibition of translation|regulation of megakaryocyte differentiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" TNS1 47.67868217 26.38885518 68.96850916 2.613546844 1.386009018 0.110834422 1 0.091830591 0.250341931 7145 tensin 1 "GO:0003723,GO:0003779,GO:0005515,GO:0005737,GO:0005856,GO:0005925,GO:0009986" RNA binding|actin binding|protein binding|cytoplasm|cytoskeleton|focal adhesion|cell surface TNS2 148.553478 153.2583512 143.8486048 0.938602064 -0.091414462 0.888573233 1 1.154199974 1.130000134 23371 tensin 2 "GO:0001822,GO:0004725,GO:0005515,GO:0005886,GO:0005925,GO:0008285,GO:0014850,GO:0019725,GO:0019900,GO:0032963,GO:0035264,GO:0035335,GO:0035556,GO:0042802,GO:0046627,GO:0046872,GO:0048871" kidney development|protein tyrosine phosphatase activity|protein binding|plasma membrane|focal adhesion|negative regulation of cell population proliferation|response to muscle activity|cellular homeostasis|kinase binding|collagen metabolic process|multicellular organism growth|peptidyl-tyrosine dephosphorylation|intracellular signal transduction|identical protein binding|negative regulation of insulin receptor signaling pathway|metal ion binding|multicellular organismal homeostasis TNS3 3738.908491 3928.894554 3548.922428 0.903287777 -0.146742408 0.64513831 1 15.93917405 15.01785395 64759 tensin 3 "GO:0005515,GO:0005829,GO:0005925" protein binding|cytosol|focal adhesion TNXB 5.537720498 8.119647747 2.95579325 0.364029739 -1.457871781 0.448526494 1 0.02958713 0.011234549 7148 tenascin XB "GO:0005178,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0007155,GO:0008201,GO:0030036,GO:0030199,GO:0031012,GO:0032963,GO:0048251,GO:0062023,GO:0070062,GO:0098633" integrin binding|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|cell adhesion|heparin binding|actin cytoskeleton organization|collagen fibril organization|extracellular matrix|collagen metabolic process|elastic fiber assembly|collagen-containing extracellular matrix|extracellular exosome|collagen fibril binding "hsa04151,hsa04510,hsa04512,hsa05165,hsa05206" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Human papillomavirus infection|MicroRNAs in cancer TOB1 857.1280859 1006.836321 707.4198511 0.702616539 -0.509190558 0.160249475 1 20.22717483 14.82414064 10140 "transducer of ERBB2, 1" "GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0008285,GO:0010468,GO:0017148,GO:0030014,GO:0030514,GO:0030971,GO:0045668,GO:0045892,GO:0046332,GO:0060212,GO:0060213,GO:0060390,GO:1900153" "transcription corepressor activity|protein binding|nucleus|cytoplasm|negative regulation of cell population proliferation|regulation of gene expression|negative regulation of translation|CCR4-NOT complex|negative regulation of BMP signaling pathway|receptor tyrosine kinase binding|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|SMAD binding|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of SMAD protein signal transduction|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" hsa03018 RNA degradation TOB2 2074.486361 2055.285836 2093.686885 1.018684043 0.026706652 0.93531919 1 12.98565082 13.79809573 10766 "transducer of ERBB2, 2" "GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007292,GO:0008285,GO:0010468,GO:0042809,GO:0045671,GO:0045778,GO:0045892" "transcription corepressor activity|protein binding|nucleus|cytoplasm|cytosol|female gamete generation|negative regulation of cell population proliferation|regulation of gene expression|vitamin D receptor binding|negative regulation of osteoclast differentiation|positive regulation of ossification|negative regulation of transcription, DNA-templated" hsa03018 RNA degradation TOE1 496.3961083 526.7621476 466.030069 0.884706829 -0.176728636 0.668624976 1 12.0011896 11.07489471 114034 "target of EGR1, exonuclease" "GO:0000175,GO:0003723,GO:0004535,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0015030,GO:0016604,GO:0016607,GO:0017069,GO:0034472,GO:0046872,GO:0090503" "3'-5'-exoribonuclease activity|RNA binding|poly(A)-specific ribonuclease activity|protein binding|nucleoplasm|nucleolus|cytoplasm|Cajal body|nuclear body|nuclear speck|snRNA binding|snRNA 3'-end processing|metal ion binding|RNA phosphodiester bond hydrolysis, exonucleolytic" TOGARAM1 479.8450515 472.9694813 486.7206218 1.029074055 0.041346806 0.925390869 1 4.124351875 4.427089165 23116 TOG array regulator of axonemal microtubules 1 "GO:0000226,GO:0005815,GO:0005874,GO:0005876,GO:0005881,GO:0005929,GO:0008017,GO:0031110,GO:0031116,GO:0035082,GO:0036064,GO:0072686,GO:0090307,GO:1905515" microtubule cytoskeleton organization|microtubule organizing center|microtubule|spindle microtubule|cytoplasmic microtubule|cilium|microtubule binding|regulation of microtubule polymerization or depolymerization|positive regulation of microtubule polymerization|axoneme assembly|ciliary basal body|mitotic spindle|mitotic spindle assembly|non-motile cilium assembly TOLLIP 1551.164228 1472.70111 1629.627345 1.106556744 0.146077434 0.659117395 1 17.46361879 20.15690559 54472 toll interacting protein "GO:0005150,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006511,GO:0006914,GO:0006954,GO:0007165,GO:0016310,GO:0016604,GO:0019900,GO:0030855,GO:0031624,GO:0031625,GO:0032183,GO:0032991,GO:0033235,GO:0035325,GO:0035578,GO:0035580,GO:0036010,GO:0043130,GO:0043312,GO:0045087,GO:0045321,GO:0048471,GO:0070062,GO:0070498" "interleukin-1, type I receptor binding|protein binding|extracellular region|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|autophagy|inflammatory response|signal transduction|phosphorylation|nuclear body|kinase binding|epithelial cell differentiation|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|SUMO binding|protein-containing complex|positive regulation of protein sumoylation|Toll-like receptor binding|azurophil granule lumen|specific granule lumen|protein localization to endosome|ubiquitin binding|neutrophil degranulation|innate immune response|leukocyte activation|perinuclear region of cytoplasm|extracellular exosome|interleukin-1-mediated signaling pathway" hsa04620 Toll-like receptor signaling pathway TOM1 825.8250328 988.5671132 663.0829523 0.670751579 -0.576149549 0.114829021 1 19.82868785 13.87303908 10043 target of myb1 membrane trafficking protein "GO:0005515,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006886,GO:0006897,GO:0007165,GO:0015031,GO:0016020,GO:0016197,GO:0030276,GO:0035577,GO:0035579,GO:0043312,GO:0070062" protein binding|cytoplasm|endosome|early endosome|cytosol|plasma membrane|intracellular protein transport|endocytosis|signal transduction|protein transport|membrane|endosomal transport|clathrin binding|azurophil granule membrane|specific granule membrane|neutrophil degranulation|extracellular exosome TOM1L1 867.7529564 689.1551025 1046.35081 1.518309603 0.602466005 0.096093652 1 11.42122865 18.08793942 10040 target of myb1 like 1 membrane trafficking protein "GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005795,GO:0005829,GO:0006886,GO:0007165,GO:0010008,GO:0016020,GO:0017124,GO:0019901,GO:0030276,GO:0030295,GO:0031954,GO:0032147,GO:0043130,GO:0043162,GO:0045839,GO:0070062,GO:2000278" protein binding|cytoplasm|lysosome|endosome|Golgi stack|cytosol|intracellular protein transport|signal transduction|endosome membrane|membrane|SH3 domain binding|protein kinase binding|clathrin binding|protein kinase activator activity|positive regulation of protein autophosphorylation|activation of protein kinase activity|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|negative regulation of mitotic nuclear division|extracellular exosome|regulation of DNA biosynthetic process TOM1L2 889.8120422 749.0375047 1030.58658 1.375881145 0.460355849 0.2010115 1 6.512636423 9.346600556 146691 target of myb1 like 2 membrane trafficking protein "GO:0005515,GO:0005768,GO:0006886,GO:0007165,GO:0016020,GO:0019901,GO:0030276,GO:0045839,GO:0070062" protein binding|endosome|intracellular protein transport|signal transduction|membrane|protein kinase binding|clathrin binding|negative regulation of mitotic nuclear division|extracellular exosome TOMM20 4238.834181 4191.768149 4285.900212 1.02245641 0.032039338 0.920747788 1 64.66593637 68.96620077 9804 translocase of outer mitochondrial membrane 20 "GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0014850,GO:0015450,GO:0016031,GO:0016236,GO:0016579,GO:0030150,GO:0030943,GO:0031307,GO:0044233,GO:0051082,GO:1905242" "protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|response to muscle activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|tRNA import into mitochondrion|macroautophagy|protein deubiquitination|protein import into mitochondrial matrix|mitochondrion targeting sequence binding|integral component of mitochondrial outer membrane|mitochondria-associated endoplasmic reticulum membrane|unfolded protein binding|response to 3,3',5-triiodo-L-thyronine" TOMM22 1537.300256 1602.615474 1471.985038 0.918489221 -0.122665304 0.711679488 1 39.96396852 38.28764036 56993 translocase of outer mitochondrial membrane 22 "GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0016020,GO:0016021,GO:0016236,GO:0043065,GO:0045040,GO:0071806" protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|membrane|integral component of membrane|macroautophagy|positive regulation of apoptotic process|protein insertion into mitochondrial outer membrane|protein transmembrane transport TOMM34 2099.956015 2213.618967 1986.293064 0.897305766 -0.156328412 0.627084634 1 44.3832112 41.54082424 10953 translocase of outer mitochondrial membrane 34 "GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006626,GO:0016020,GO:0016021,GO:0031072,GO:0043231" protein binding|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|protein targeting to mitochondrion|membrane|integral component of membrane|heat shock protein binding|intracellular membrane-bounded organelle TOMM40 1474.664458 1564.047147 1385.28177 0.885703332 -0.175104549 0.598913342 1 43.33340831 40.0338223 10452 translocase of outer mitochondrial membrane 40 "GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0005743,GO:0005829,GO:0006626,GO:0008320,GO:0015288,GO:0016021,GO:0016236,GO:0030150,GO:0031307,GO:0044233,GO:0046930" protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|mitochondrial inner membrane|cytosol|protein targeting to mitochondrion|protein transmembrane transporter activity|porin activity|integral component of membrane|macroautophagy|protein import into mitochondrial matrix|integral component of mitochondrial outer membrane|mitochondria-associated endoplasmic reticulum membrane|pore complex "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases TOMM40L 477.0053029 514.582676 439.4279298 0.853950104 -0.227776318 0.58379168 1 8.965186515 7.98560372 84134 translocase of outer mitochondrial membrane 40 like "GO:0003674,GO:0005742,GO:0008150,GO:0008320,GO:0015288,GO:0030150,GO:0030943,GO:0032991,GO:0046930,GO:0070678" molecular_function|mitochondrial outer membrane translocase complex|biological_process|protein transmembrane transporter activity|porin activity|protein import into mitochondrial matrix|mitochondrion targeting sequence binding|protein-containing complex|pore complex|preprotein binding "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases TOMM5 1586.585004 1705.126027 1468.043981 0.860959224 -0.215983184 0.512350187 1 99.83655253 89.65780222 401505 translocase of outer mitochondrial membrane 5 "GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0016021,GO:0016236" mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|integral component of membrane|macroautophagy TOMM6 1300.517116 1311.323111 1289.711121 0.983518944 -0.023975254 0.94582849 1 110.3220756 113.1777571 100188893 translocase of outer mitochondrial membrane 6 "GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0015031,GO:0016236" protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein transport|macroautophagy TOMM7 1782.084278 1902.027485 1662.141071 0.873878576 -0.194495261 0.550420731 1 221.9607884 202.3220799 54543 translocase of outer mitochondrial membrane 7 "GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0016021,GO:0016236,GO:0030150,GO:0031647,GO:0098779,GO:1903955" protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|integral component of membrane|macroautophagy|protein import into mitochondrial matrix|regulation of protein stability|positive regulation of mitophagy in response to mitochondrial depolarization|positive regulation of protein targeting to mitochondrion hsa04137 Mitophagy - animal TOMM70 2044.596378 2099.943899 1989.248857 0.947286667 -0.078127016 0.809299362 1 25.940183 25.63128562 9868 translocase of outer mitochondrial membrane 70 "GO:0002218,GO:0002230,GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0016020,GO:0016021,GO:0016236,GO:0030150,GO:0030943,GO:0032728,GO:0042981,GO:0045039,GO:0070062,GO:0098586" activation of innate immune response|positive regulation of defense response to virus by host|protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|membrane|integral component of membrane|macroautophagy|protein import into mitochondrial matrix|mitochondrion targeting sequence binding|positive regulation of interferon-beta production|regulation of apoptotic process|protein insertion into mitochondrial inner membrane|extracellular exosome|cellular response to virus TONSL 1242.776711 1102.242182 1383.311241 1.254997553 0.327684551 0.335672427 1 12.18081563 15.94539119 4796 "tonsoku like, DNA repair protein" "GO:0000724,GO:0005515,GO:0005654,GO:0005662,GO:0005737,GO:0016604,GO:0031297,GO:0035101,GO:0042393,GO:0042555,GO:0043596" double-strand break repair via homologous recombination|protein binding|nucleoplasm|DNA replication factor A complex|cytoplasm|nuclear body|replication fork processing|FACT complex|histone binding|MCM complex|nuclear replication fork TOP1 3445.566919 3947.163761 2943.970077 0.745844423 -0.423053368 0.183876838 1 53.53773962 41.65088247 7150 DNA topoisomerase I "GO:0000228,GO:0000932,GO:0000978,GO:0001650,GO:0003677,GO:0003682,GO:0003690,GO:0003697,GO:0003723,GO:0003917,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006260,GO:0006265,GO:0006338,GO:0007059,GO:0007623,GO:0012501,GO:0016032,GO:0016310,GO:0018105,GO:0019904,GO:0032922,GO:0032993,GO:0040016,GO:0042493,GO:0043204,GO:0097100" "nuclear chromosome|P-body|RNA polymerase II cis-regulatory region sequence-specific DNA binding|fibrillar center|DNA binding|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|RNA binding|DNA topoisomerase type I (single strand cut, ATP-independent) activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|DNA replication|DNA topological change|chromatin remodeling|chromosome segregation|circadian rhythm|programmed cell death|viral process|phosphorylation|peptidyl-serine phosphorylation|protein domain specific binding|circadian regulation of gene expression|protein-DNA complex|embryonic cleavage|response to drug|perikaryon|supercoiled DNA binding" other TOP1MT 1280.087106 1228.096722 1332.077491 1.084668225 0.117253823 0.730671344 1 23.13081684 26.1700057 116447 DNA topoisomerase I mitochondrial "GO:0003677,GO:0003917,GO:0005654,GO:0005694,GO:0005739,GO:0006260,GO:0006265,GO:0042645" "DNA binding|DNA topoisomerase type I (single strand cut, ATP-independent) activity|nucleoplasm|chromosome|mitochondrion|DNA replication|DNA topological change|mitochondrial nucleoid" TOP2A 9072.130193 7598.975335 10545.28505 1.387724606 0.472721293 0.157320051 1 66.09330125 95.67019589 7153 DNA topoisomerase II alpha "GO:0000228,GO:0000287,GO:0000712,GO:0000775,GO:0000793,GO:0000819,GO:0002244,GO:0003677,GO:0003682,GO:0003723,GO:0003918,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0006265,GO:0006266,GO:0006974,GO:0007059,GO:0007143,GO:0008022,GO:0008094,GO:0008301,GO:0009330,GO:0019899,GO:0030263,GO:0032991,GO:0040016,GO:0042752,GO:0042803,GO:0042826,GO:0043065,GO:0043130,GO:0044774,GO:0045870,GO:0045944,GO:0046982,GO:0048511,GO:1905463,GO:1990904" "nuclear chromosome|magnesium ion binding|resolution of meiotic recombination intermediates|chromosome, centromeric region|condensed chromosome|sister chromatid segregation|hematopoietic progenitor cell differentiation|DNA binding|chromatin binding|RNA binding|DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity|protein kinase C binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centriole|DNA topological change|DNA ligation|cellular response to DNA damage stimulus|chromosome segregation|female meiotic nuclear division|protein C-terminus binding|DNA-dependent ATPase activity|DNA binding, bending|DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex|enzyme binding|apoptotic chromosome condensation|protein-containing complex|embryonic cleavage|regulation of circadian rhythm|protein homodimerization activity|histone deacetylase binding|positive regulation of apoptotic process|ubiquitin binding|mitotic DNA integrity checkpoint|positive regulation of single stranded viral RNA replication via double stranded DNA intermediate|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|rhythmic process|negative regulation of DNA duplex unwinding|ribonucleoprotein complex" hsa01524 Platinum drug resistance TOP2B 5368.783517 4922.536447 5815.030586 1.181307777 0.240384892 0.455804313 1 42.42115116 52.27107626 7155 DNA topoisomerase II beta "GO:0000712,GO:0000792,GO:0000819,GO:0001764,GO:0003677,GO:0003682,GO:0003918,GO:0005080,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006265,GO:0007409,GO:0008022,GO:0019899,GO:0030900,GO:0042826,GO:0044774,GO:0045870,GO:0046872,GO:0046982,GO:1990904" "resolution of meiotic recombination intermediates|heterochromatin|sister chromatid segregation|neuron migration|DNA binding|chromatin binding|DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity|protein kinase C binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA topological change|axonogenesis|protein C-terminus binding|enzyme binding|forebrain development|histone deacetylase binding|mitotic DNA integrity checkpoint|positive regulation of single stranded viral RNA replication via double stranded DNA intermediate|metal ion binding|protein heterodimerization activity|ribonucleoprotein complex" hsa01524 Platinum drug resistance TOP3A 1194.971098 1168.21432 1221.727877 1.045807996 0.064618006 0.852373619 1 7.302633186 7.966129721 7156 DNA topoisomerase III alpha "GO:0003677,GO:0003697,GO:0003916,GO:0003917,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005759,GO:0006260,GO:0006265,GO:0008270,GO:0016605,GO:0032042,GO:0051304,GO:0051321,GO:1901796" "DNA binding|single-stranded DNA binding|DNA topoisomerase activity|DNA topoisomerase type I (single strand cut, ATP-independent) activity|protein binding|nucleus|nucleoplasm|chromosome|mitochondrial matrix|DNA replication|DNA topological change|zinc ion binding|PML body|mitochondrial DNA metabolic process|chromosome separation|meiotic cell cycle|regulation of signal transduction by p53 class mediator" "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway TOP3B 487.8904704 484.1339969 491.6469439 1.015518321 0.022216268 0.962326241 1 7.12988631 7.552422853 8940 DNA topoisomerase III beta "GO:0000793,GO:0003677,GO:0003723,GO:0003916,GO:0003917,GO:0005515,GO:0005634,GO:0006265,GO:0007059" "condensed chromosome|DNA binding|RNA binding|DNA topoisomerase activity|DNA topoisomerase type I (single strand cut, ATP-independent) activity|protein binding|nucleus|DNA topological change|chromosome segregation" "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway TOPBP1 1825.356486 1593.48087 2057.232102 1.29103031 0.368522872 0.256416729 1 14.21098514 19.13711883 11073 DNA topoisomerase II binding protein 1 "GO:0000794,GO:0000922,GO:0001673,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005815,GO:0005886,GO:0006259,GO:0006260,GO:0006270,GO:0006281,GO:0006974,GO:0007095,GO:0008022,GO:0010212,GO:0015629,GO:0016604,GO:0016605,GO:0033314,GO:0042802,GO:0043231,GO:1901796" condensed nuclear chromosome|spindle pole|male germ cell nucleus|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|microtubule organizing center|plasma membrane|DNA metabolic process|DNA replication|DNA replication initiation|DNA repair|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|protein C-terminus binding|response to ionizing radiation|actin cytoskeleton|nuclear body|PML body|mitotic DNA replication checkpoint|identical protein binding|intracellular membrane-bounded organelle|regulation of signal transduction by p53 class mediator hsa03440 Homologous recombination TOPORS 1215.572576 1162.124584 1269.020569 1.09198324 0.126950714 0.711399494 1 14.24776336 16.22850807 10210 "TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase" "GO:0000151,GO:0000209,GO:0000922,GO:0000930,GO:0003677,GO:0003823,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005814,GO:0005868,GO:0006351,GO:0006511,GO:0006513,GO:0006974,GO:0008630,GO:0010842,GO:0016605,GO:0016607,GO:0016925,GO:0019789,GO:0030496,GO:0032391,GO:0034504,GO:0035845,GO:0036064,GO:0042127,GO:0042771,GO:0043066,GO:0043161,GO:0044547,GO:0045893,GO:0046548,GO:0046549,GO:0046872,GO:0051443,GO:0051457,GO:0061630,GO:0070936" "ubiquitin ligase complex|protein polyubiquitination|spindle pole|gamma-tubulin complex|DNA binding|antigen binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|centriole|cytoplasmic dynein complex|transcription, DNA-templated|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|intrinsic apoptotic signaling pathway in response to DNA damage|retina layer formation|PML body|nuclear speck|protein sumoylation|SUMO transferase activity|midbody|photoreceptor connecting cilium|protein localization to nucleus|photoreceptor cell outer segment organization|ciliary basal body|regulation of cell population proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|DNA topoisomerase binding|positive regulation of transcription, DNA-templated|retinal rod cell development|retinal cone cell development|metal ion binding|positive regulation of ubiquitin-protein transferase activity|maintenance of protein location in nucleus|ubiquitin protein ligase activity|protein K48-linked ubiquitination" TOR1A 1609.174578 1666.5577 1551.791456 0.931135751 -0.10293658 0.755454144 1 40.57945589 39.41260593 1861 torsin family 1 member A "GO:0000338,GO:0005515,GO:0005524,GO:0005635,GO:0005783,GO:0005788,GO:0005829,GO:0005856,GO:0006979,GO:0006996,GO:0006998,GO:0007155,GO:0008021,GO:0008092,GO:0016020,GO:0016887,GO:0019894,GO:0030141,GO:0030426,GO:0030659,GO:0031175,GO:0031965,GO:0034504,GO:0042406,GO:0042802,GO:0043231,GO:0044319,GO:0045104,GO:0048489,GO:0051082,GO:0051085,GO:0051584,GO:0051787,GO:0061077,GO:0070062,GO:0071712,GO:0071763,GO:0072321,GO:1900244,GO:2000008" "protein deneddylation|protein binding|ATP binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum lumen|cytosol|cytoskeleton|response to oxidative stress|organelle organization|nuclear envelope organization|cell adhesion|synaptic vesicle|cytoskeletal protein binding|membrane|ATPase activity|kinesin binding|secretory granule|growth cone|cytoplasmic vesicle membrane|neuron projection development|nuclear membrane|protein localization to nucleus|extrinsic component of endoplasmic reticulum membrane|identical protein binding|intracellular membrane-bounded organelle|wound healing, spreading of cells|intermediate filament cytoskeleton organization|synaptic vesicle transport|unfolded protein binding|chaperone cofactor-dependent protein refolding|regulation of dopamine uptake involved in synaptic transmission|misfolded protein binding|chaperone-mediated protein folding|extracellular exosome|ER-associated misfolded protein catabolic process|nuclear membrane organization|chaperone-mediated protein transport|positive regulation of synaptic vesicle endocytosis|regulation of protein localization to cell surface" TOR1AIP1 1335.245584 1429.058003 1241.433165 0.868707332 -0.203057882 0.547092185 1 18.99652138 17.21327461 26092 torsin 1A interacting protein 1 "GO:0001671,GO:0005515,GO:0005634,GO:0005637,GO:0008092,GO:0016021,GO:0031965,GO:0032781,GO:0034504,GO:0051117" ATPase activator activity|protein binding|nucleus|nuclear inner membrane|cytoskeletal protein binding|integral component of membrane|nuclear membrane|positive regulation of ATPase activity|protein localization to nucleus|ATPase binding TOR1AIP2 1782.958941 1793.427196 1772.490685 0.988325977 -0.016941135 0.960316163 1 5.429863741 5.59764138 163590 torsin 1A interacting protein 2 "GO:0001671,GO:0005515,GO:0005783,GO:0005789,GO:0007029,GO:0016021,GO:0031965,GO:0032781,GO:0051117,GO:0090435" ATPase activator activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum organization|integral component of membrane|nuclear membrane|positive regulation of ATPase activity|ATPase binding|protein localization to nuclear envelope TOR1B 1038.269518 1165.169452 911.3695853 0.78217772 -0.354431653 0.311550917 1 21.2731515 17.35614237 27348 torsin family 1 member B "GO:0005515,GO:0005524,GO:0005635,GO:0005783,GO:0005788,GO:0006986,GO:0007029,GO:0016887,GO:0019894,GO:0031965,GO:0034504,GO:0042802,GO:0051085,GO:0070062,GO:0071763" protein binding|ATP binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum lumen|response to unfolded protein|endoplasmic reticulum organization|ATPase activity|kinesin binding|nuclear membrane|protein localization to nucleus|identical protein binding|chaperone cofactor-dependent protein refolding|extracellular exosome|nuclear membrane organization TOR2A 325.5311664 296.3671428 354.69519 1.196810101 0.259194256 0.576636037 1 6.057284205 7.561694485 27433 torsin family 2 member A "GO:0005524,GO:0005635,GO:0005788,GO:0016887,GO:0042802,GO:0051085" ATP binding|nuclear envelope|endoplasmic reticulum lumen|ATPase activity|identical protein binding|chaperone cofactor-dependent protein refolding TOR3A 958.4524604 928.6847111 988.2202098 1.064107332 0.089643676 0.802936431 1 23.15834781 25.7044868 64222 torsin family 3 member A "GO:0005524,GO:0005635,GO:0005783,GO:0005788,GO:0016887,GO:0070062" ATP binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum lumen|ATPase activity|extracellular exosome TOR4A 2021.141789 1944.655635 2097.627943 1.078662929 0.109244107 0.735348261 1 23.61302987 26.5676658 54863 torsin family 4 member A "GO:0002576,GO:0005524,GO:0005576,GO:0005635,GO:0005788,GO:0016021,GO:0016887,GO:0031093" platelet degranulation|ATP binding|extracellular region|nuclear envelope|endoplasmic reticulum lumen|integral component of membrane|ATPase activity|platelet alpha granule lumen TOX2 1312.166099 1434.132783 1190.199415 0.829908799 -0.268975292 0.425816643 1 25.59329322 22.15503656 84969 TOX high mobility group box family member 2 "GO:0003713,GO:0005634,GO:0005654,GO:0006357,GO:0031490,GO:0045944" transcription coactivator activity|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|chromatin DNA binding|positive regulation of transcription by RNA polymerase II TOX4 1556.260534 1585.361223 1527.159846 0.963288255 -0.053960519 0.8718745 1 17.78753946 17.87261381 9878 TOX high mobility group box family member 4 "GO:0000781,GO:0000785,GO:0005515,GO:0005634,GO:0006357,GO:0031490,GO:0072357" "chromosome, telomeric region|chromatin|protein binding|nucleus|regulation of transcription by RNA polymerase II|chromatin DNA binding|PTW/PP1 phosphatase complex" TP53 254.8323824 279.1128913 230.5518735 0.826016571 -0.27575737 0.583134719 1 5.103279167 4.396975201 7157 tumor protein p53 "GO:0000122,GO:0000733,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001046,GO:0001085,GO:0001094,GO:0001216,GO:0001228,GO:0001701,GO:0001756,GO:0001836,GO:0002020,GO:0002039,GO:0002244,GO:0002309,GO:0002326,GO:0002360,GO:0002931,GO:0003677,GO:0003682,GO:0003700,GO:0003730,GO:0005507,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005667,GO:0005669,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0005783,GO:0005813,GO:0005829,GO:0006289,GO:0006302,GO:0006355,GO:0006357,GO:0006606,GO:0006914,GO:0006974,GO:0006977,GO:0006978,GO:0006983,GO:0007050,GO:0007179,GO:0007265,GO:0007369,GO:0007406,GO:0007569,GO:0008104,GO:0008134,GO:0008156,GO:0008270,GO:0008285,GO:0008340,GO:0009299,GO:0009303,GO:0009651,GO:0010165,GO:0010332,GO:0010628,GO:0010666,GO:0016032,GO:0016363,GO:0016579,GO:0016604,GO:0016605,GO:0019221,GO:0019899,GO:0019901,GO:0019903,GO:0021549,GO:0030308,GO:0030330,GO:0030512,GO:0030971,GO:0031065,GO:0031497,GO:0031571,GO:0031625,GO:0032991,GO:0033077,GO:0033209,GO:0034103,GO:0034644,GO:0035033,GO:0035035,GO:0035264,GO:0035690,GO:0035794,GO:0035861,GO:0036003,GO:0042149,GO:0042771,GO:0042802,GO:0042826,GO:0042981,GO:0043065,GO:0043066,GO:0043153,GO:0043504,GO:0043516,GO:0043525,GO:0043621,GO:0045861,GO:0045892,GO:0045893,GO:0045899,GO:0045944,GO:0046677,GO:0046827,GO:0046982,GO:0047485,GO:0048147,GO:0048512,GO:0048539,GO:0048568,GO:0050731,GO:0050821,GO:0051087,GO:0051097,GO:0051262,GO:0051402,GO:0051721,GO:0051974,GO:0060218,GO:0060333,GO:0060411,GO:0061419,GO:0062100,GO:0065003,GO:0070059,GO:0070245,GO:0070266,GO:0071158,GO:0071456,GO:0071479,GO:0071480,GO:0071494,GO:0071850,GO:0072331,GO:0072332,GO:0072717,GO:0090200,GO:0090343,GO:0090399,GO:0090403,GO:0097193,GO:0097252,GO:0097371,GO:0097718,GO:1900119,GO:1900740,GO:1901525,GO:1901796,GO:1902108,GO:1902253,GO:1902749,GO:1902895,GO:1903799,GO:1903800,GO:1904024,GO:1905856,GO:1990144,GO:1990248,GO:1990440,GO:1990841,GO:2000269,GO:2000378,GO:2000379,GO:2000772,GO:2001244" "negative regulation of transcription by RNA polymerase II|DNA strand renaturation|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|core promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|TFIID-class transcription factor complex binding|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|somitogenesis|release of cytochrome c from mitochondria|protease binding|p53 binding|hematopoietic progenitor cell differentiation|T cell proliferation involved in immune response|B cell lineage commitment|T cell lineage commitment|response to ischemia|DNA binding|chromatin binding|DNA-binding transcription factor activity|mRNA 3'-UTR binding|copper ion binding|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|transcription regulator complex|transcription factor TFIID complex|nucleolus|cytoplasm|mitochondrion|mitochondrial matrix|endoplasmic reticulum|centrosome|cytosol|nucleotide-excision repair|double-strand break repair|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|protein import into nucleus|autophagy|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|cell cycle arrest|transforming growth factor beta receptor signaling pathway|Ras protein signal transduction|gastrulation|negative regulation of neuroblast proliferation|cell aging|protein localization|transcription factor binding|negative regulation of DNA replication|zinc ion binding|negative regulation of cell population proliferation|determination of adult lifespan|mRNA transcription|rRNA transcription|response to salt stress|response to X-ray|response to gamma radiation|positive regulation of gene expression|positive regulation of cardiac muscle cell apoptotic process|viral process|nuclear matrix|protein deubiquitination|nuclear body|PML body|cytokine-mediated signaling pathway|enzyme binding|protein kinase binding|protein phosphatase binding|cerebellum development|negative regulation of cell growth|DNA damage response, signal transduction by p53 class mediator|negative regulation of transforming growth factor beta receptor signaling pathway|receptor tyrosine kinase binding|positive regulation of histone deacetylation|chromatin assembly|mitotic G1 DNA damage checkpoint|ubiquitin protein ligase binding|protein-containing complex|T cell differentiation in thymus|tumor necrosis factor-mediated signaling pathway|regulation of tissue remodeling|cellular response to UV|histone deacetylase regulator activity|histone acetyltransferase binding|multicellular organism growth|cellular response to drug|positive regulation of mitochondrial membrane permeability|site of double-strand break|positive regulation of transcription from RNA polymerase II promoter in response to stress|cellular response to glucose starvation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|histone deacetylase binding|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|entrainment of circadian clock by photoperiod|mitochondrial DNA repair|regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of neuron apoptotic process|protein self-association|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of RNA polymerase II transcription preinitiation complex assembly|positive regulation of transcription by RNA polymerase II|response to antibiotic|positive regulation of protein export from nucleus|protein heterodimerization activity|protein N-terminus binding|negative regulation of fibroblast proliferation|circadian behavior|bone marrow development|embryonic organ development|positive regulation of peptidyl-tyrosine phosphorylation|protein stabilization|chaperone binding|negative regulation of helicase activity|protein tetramerization|neuron apoptotic process|protein phosphatase 2A binding|negative regulation of telomerase activity|hematopoietic stem cell differentiation|interferon-gamma-mediated signaling pathway|cardiac septum morphogenesis|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of programmed necrotic cell death|protein-containing complex assembly|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of thymocyte apoptotic process|necroptotic process|positive regulation of cell cycle arrest|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to gamma radiation|cellular response to UV-C|mitotic cell cycle arrest|signal transduction by p53 class mediator|intrinsic apoptotic signaling pathway by p53 class mediator|cellular response to actinomycin D|positive regulation of release of cytochrome c from mitochondria|positive regulation of cell aging|replicative senescence|oxidative stress-induced premature senescence|intrinsic apoptotic signaling pathway|oligodendrocyte apoptotic process|MDM2/MDM4 family protein binding|disordered domain specific binding|positive regulation of execution phase of apoptosis|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|negative regulation of mitophagy|regulation of signal transduction by p53 class mediator|regulation of mitochondrial membrane permeability involved in apoptotic process|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|regulation of cell cycle G2/M phase transition|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of production of miRNAs involved in gene silencing by miRNA|negative regulation of glucose catabolic process to lactate via pyruvate|negative regulation of pentose-phosphate shunt|intrinsic apoptotic signaling pathway in response to hypoxia|regulation of transcription from RNA polymerase II promoter in response to DNA damage|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|promoter-specific chromatin binding|regulation of fibroblast apoptotic process|negative regulation of reactive oxygen species metabolic process|positive regulation of reactive oxygen species metabolic process|regulation of cellular senescence|positive regulation of intrinsic apoptotic signaling pathway" "hsa01522,hsa01524,hsa04010,hsa04071,hsa04110,hsa04115,hsa04137,hsa04151,hsa04210,hsa04211,hsa04216,hsa04218,hsa04310,hsa04722,hsa04919,hsa05012,hsa05014,hsa05016,hsa05131,hsa05160,hsa05161,hsa05162,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05200,hsa05202,hsa05203,hsa05205,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05217,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05418" Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|Sphingolipid signaling pathway|Cell cycle|p53 signaling pathway|Mitophagy - animal|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Ferroptosis|Cellular senescence|Wnt signaling pathway|Neurotrophin signaling pathway|Thyroid hormone signaling pathway|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Shigellosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Fluid shear stress and atherosclerosis P53 TP53BP1 2721.970861 2403.415733 3040.525989 1.265085332 0.3392347 0.287018798 1 10.53435986 13.90093139 7158 tumor protein p53 binding protein 1 "GO:0000077,GO:0000777,GO:0000781,GO:0001102,GO:0002039,GO:0003684,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0006303,GO:0006974,GO:0016604,GO:0035064,GO:0035861,GO:0042162,GO:0042393,GO:0045830,GO:0045893,GO:0045944,GO:0051091,GO:0051260,GO:0061649,GO:0071481,GO:1990391,GO:2000042" "DNA damage checkpoint|condensed chromosome kinetochore|chromosome, telomeric region|RNA polymerase II activating transcription factor binding|p53 binding|damaged DNA binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|replication fork|cytoplasm|double-strand break repair via nonhomologous end joining|cellular response to DNA damage stimulus|nuclear body|methylated histone binding|site of double-strand break|telomeric DNA binding|histone binding|positive regulation of isotype switching|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|protein homooligomerization|ubiquitin modification-dependent histone binding|cellular response to X-ray|DNA repair complex|negative regulation of double-strand break repair via homologous recombination" hsa04621 NOD-like receptor signaling pathway TP53BP2 1762.131808 2188.245068 1336.018549 0.610543384 -0.711834281 0.029335485 0.763169617 22.37119358 14.24694065 7159 tumor protein p53 binding protein 2 "GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0007049,GO:0007165,GO:0017124,GO:0030054,GO:0042802,GO:0042981,GO:0045786,GO:0048471,GO:0051059,GO:0072332,GO:1900119,GO:1900740,GO:1901216,GO:1901796" p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|cell cycle|signal transduction|SH3 domain binding|cell junction|identical protein binding|regulation of apoptotic process|negative regulation of cell cycle|perinuclear region of cytoplasm|NF-kappaB binding|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of execution phase of apoptosis|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of neuron death|regulation of signal transduction by p53 class mediator hsa04390 Hippo signaling pathway TP53I13 953.4682391 722.6486495 1184.287829 1.638815529 0.712653468 0.045455811 0.96408227 18.64472988 31.87147008 90313 tumor protein p53 inducible protein 13 "GO:0003674,GO:0005515,GO:0005737,GO:0005886,GO:0009411,GO:0014070,GO:0016021,GO:0042493,GO:0045786" molecular_function|protein binding|cytoplasm|plasma membrane|response to UV|response to organic cyclic compound|integral component of membrane|response to drug|negative regulation of cell cycle TP53I3 464.9027817 461.8049656 468.0005979 1.013416123 0.019226687 0.968837015 1 18.57727749 19.63748234 9540 tumor protein p53 inducible protein 3 "GO:0003960,GO:0005829,GO:0006739,GO:0042803,GO:0042981,GO:0048038,GO:0055114,GO:0070402" NADPH:quinone reductase activity|cytosol|NADP metabolic process|protein homodimerization activity|regulation of apoptotic process|quinone binding|oxidation-reduction process|NADPH binding hsa04115 p53 signaling pathway TP53INP1 378.0889117 353.204677 402.9731464 1.140905465 0.190179256 0.669455639 1 3.122459567 3.715886273 94241 tumor protein p53 inducible nuclear protein 1 "GO:0000045,GO:0005515,GO:0005634,GO:0005654,GO:0005776,GO:0005829,GO:0006915,GO:0007050,GO:0008285,GO:0009408,GO:0010508,GO:0010629,GO:0016209,GO:0016605,GO:0030336,GO:0031410,GO:0034644,GO:0042981,GO:0043065,GO:0045893,GO:0048102,GO:0048147,GO:0071361,GO:0071447,GO:0072703,GO:0098869,GO:1901796,GO:1904761" "autophagosome assembly|protein binding|nucleus|nucleoplasm|autophagosome|cytosol|apoptotic process|cell cycle arrest|negative regulation of cell population proliferation|response to heat|positive regulation of autophagy|negative regulation of gene expression|antioxidant activity|PML body|negative regulation of cell migration|cytoplasmic vesicle|cellular response to UV|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|autophagic cell death|negative regulation of fibroblast proliferation|cellular response to ethanol|cellular response to hydroperoxide|cellular response to methyl methanesulfonate|cellular oxidant detoxification|regulation of signal transduction by p53 class mediator|negative regulation of myofibroblast differentiation" TP53INP2 1187.54648 1233.171502 1141.921459 0.926003769 -0.110910029 0.747756565 1 14.90591556 14.39750841 58476 tumor protein p53 inducible nuclear protein 2 "GO:0000045,GO:0001649,GO:0001894,GO:0005515,GO:0005634,GO:0005776,GO:0005829,GO:0006511,GO:0010508,GO:0016605,GO:0031410,GO:0043130,GO:0045893,GO:1903828" "autophagosome assembly|osteoblast differentiation|tissue homeostasis|protein binding|nucleus|autophagosome|cytosol|ubiquitin-dependent protein catabolic process|positive regulation of autophagy|PML body|cytoplasmic vesicle|ubiquitin binding|positive regulation of transcription, DNA-templated|negative regulation of cellular protein localization" hsa04140 Autophagy - animal TP53RK 576.1174108 655.6615556 496.5732659 0.757362181 -0.400944712 0.309995185 1 10.44243546 8.249380663 112858 TP53 regulating kinase "GO:0000408,GO:0002039,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0008033,GO:0016787,GO:0070525,GO:0106310,GO:0106311,GO:1901796" EKC/KEOPS complex|p53 binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|tRNA processing|hydrolase activity|tRNA threonylcarbamoyladenosine metabolic process|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator TP73 459.506838 362.3392807 556.6743953 1.536334659 0.619492512 0.138274237 1 3.29405965 5.278775802 7161 tumor protein p73 "GO:0000187,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001822,GO:0002039,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005794,GO:0005829,GO:0006298,GO:0006357,GO:0006974,GO:0007050,GO:0007346,GO:0008134,GO:0008630,GO:0010243,GO:0010468,GO:0016032,GO:0019901,GO:0030054,GO:0042493,GO:0042771,GO:0042802,GO:0042981,GO:0043065,GO:0043231,GO:0045665,GO:0045893,GO:0045944,GO:0046872,GO:0048714,GO:0051262,GO:0060044,GO:0071158,GO:0097371,GO:1900740,GO:1901796,GO:1902036" "activation of MAPK activity|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|kidney development|p53 binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|Golgi apparatus|cytosol|mismatch repair|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|cell cycle arrest|regulation of mitotic cell cycle|transcription factor binding|intrinsic apoptotic signaling pathway in response to DNA damage|response to organonitrogen compound|regulation of gene expression|viral process|protein kinase binding|cell junction|response to drug|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of oligodendrocyte differentiation|protein tetramerization|negative regulation of cardiac muscle cell proliferation|positive regulation of cell cycle arrest|MDM2/MDM4 family protein binding|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of signal transduction by p53 class mediator|regulation of hematopoietic stem cell differentiation" "hsa04115,hsa04390,hsa04722,hsa05162" p53 signaling pathway|Hippo signaling pathway|Neurotrophin signaling pathway|Measles P53 TPBG 1818.300045 2087.764427 1548.835663 0.741863231 -0.430774858 0.184861654 1 28.54695006 22.09019205 7162 trophoblast glycoprotein "GO:0005783,GO:0005887,GO:0007155,GO:0008285,GO:0008355,GO:0009986,GO:0030425,GO:0043679,GO:0050921,GO:0051897,GO:0051932,GO:0051965,GO:0060326,GO:0070374,GO:0072659,GO:0090497,GO:0140059" "endoplasmic reticulum|integral component of plasma membrane|cell adhesion|negative regulation of cell population proliferation|olfactory learning|cell surface|dendrite|axon terminus|positive regulation of chemotaxis|positive regulation of protein kinase B signaling|synaptic transmission, GABAergic|positive regulation of synapse assembly|cell chemotaxis|positive regulation of ERK1 and ERK2 cascade|protein localization to plasma membrane|mesenchymal cell migration|dendrite arborization" TPCN1 8608.797357 8760.084963 8457.509752 0.965459786 -0.050711927 0.879013105 1 70.6927023 71.19093583 53373 two pore segment channel 1 "GO:0005245,GO:0005248,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0010008,GO:0010508,GO:0015280,GO:0016021,GO:0034220,GO:0034765,GO:0035725,GO:0042802,GO:0042803,GO:0051209,GO:0072345,GO:0080025" "voltage-gated calcium channel activity|voltage-gated sodium channel activity|protein binding|lysosome|lysosomal membrane|endosome|endosome membrane|positive regulation of autophagy|ligand-gated sodium channel activity|integral component of membrane|ion transmembrane transport|regulation of ion transmembrane transport|sodium ion transmembrane transport|identical protein binding|protein homodimerization activity|release of sequestered calcium ion into cytosol|NAADP-sensitive calcium-release channel activity|phosphatidylinositol-3,5-bisphosphate binding" hsa04020 Calcium signaling pathway TPCN2 445.5592352 419.1768149 471.9416555 1.125877288 0.171049593 0.687630777 1 4.2724546 5.017466073 219931 two pore segment channel 2 "GO:0005245,GO:0005515,GO:0005764,GO:0005765,GO:0006874,GO:0006939,GO:0007040,GO:0010008,GO:0010506,GO:0016021,GO:0019065,GO:0019722,GO:0019901,GO:0034220,GO:0034765,GO:0042802,GO:0051209,GO:0072345" voltage-gated calcium channel activity|protein binding|lysosome|lysosomal membrane|cellular calcium ion homeostasis|smooth muscle contraction|lysosome organization|endosome membrane|regulation of autophagy|integral component of membrane|receptor-mediated endocytosis of virus by host cell|calcium-mediated signaling|protein kinase binding|ion transmembrane transport|regulation of ion transmembrane transport|identical protein binding|release of sequestered calcium ion into cytosol|NAADP-sensitive calcium-release channel activity "hsa04020,hsa04972" Calcium signaling pathway|Pancreatic secretion TPD52 1534.998915 1815.756227 1254.241602 0.690754399 -0.533755249 0.106777931 1 11.33090775 8.164024384 7163 tumor protein D52 "GO:0005509,GO:0005515,GO:0005737,GO:0005783,GO:0009653,GO:0030183,GO:0042803,GO:0046903,GO:0048471" calcium ion binding|protein binding|cytoplasm|endoplasmic reticulum|anatomical structure morphogenesis|B cell differentiation|protein homodimerization activity|secretion|perinuclear region of cytoplasm TPD52L1 234.9313774 299.4120107 170.4507441 0.569284925 -0.812777198 0.112716433 1 7.964370839 4.729302427 7164 TPD52 like 1 "GO:0000086,GO:0005515,GO:0005737,GO:0042802,GO:0042803,GO:0043406,GO:0046330,GO:0048471,GO:2001235" G2/M transition of mitotic cell cycle|protein binding|cytoplasm|identical protein binding|protein homodimerization activity|positive regulation of MAP kinase activity|positive regulation of JNK cascade|perinuclear region of cytoplasm|positive regulation of apoptotic signaling pathway TPD52L2 8263.624737 7861.848931 8665.400544 1.102208987 0.140397795 0.671899728 1 139.5146859 160.3983155 7165 TPD52 like 2 "GO:0003723,GO:0005515,GO:0005975" RNA binding|protein binding|carbohydrate metabolic process TPGS1 120.6543131 131.9442759 109.3643502 0.828867713 -0.270786228 0.678114585 1 5.998664365 5.186277084 91978 tubulin polyglutamylase complex subunit 1 "GO:0005737,GO:0005813,GO:0005874,GO:0007268,GO:0007275,GO:0007288,GO:0008017,GO:0018095,GO:0018215,GO:0030424,GO:0030425,GO:0030534,GO:0031514,GO:0045202,GO:0051648,GO:0070740" cytoplasm|centrosome|microtubule|chemical synaptic transmission|multicellular organism development|sperm axoneme assembly|microtubule binding|protein polyglutamylation|protein phosphopantetheinylation|axon|dendrite|adult behavior|motile cilium|synapse|vesicle localization|tubulin-glutamic acid ligase activity TPGS2 3456.556499 3182.901917 3730.211081 1.171952884 0.22891457 0.471905116 1 15.5226532 18.97544793 25941 tubulin polyglutamylase complex subunit 2 "GO:0005515,GO:0005737,GO:0005874,GO:0018095" protein binding|cytoplasm|microtubule|protein polyglutamylation TPH1 12.03101386 14.20938356 9.852644165 0.693389979 -0.528261108 0.729410839 1 0.149120421 0.107852598 7166 tryptophan hydroxylase 1 "GO:0004510,GO:0005506,GO:0005515,GO:0005829,GO:0007623,GO:0009072,GO:0030279,GO:0035902,GO:0042427,GO:0043005,GO:0045600,GO:0046219,GO:0046849,GO:0055114,GO:0060749" tryptophan 5-monooxygenase activity|iron ion binding|protein binding|cytosol|circadian rhythm|aromatic amino acid family metabolic process|negative regulation of ossification|response to immobilization stress|serotonin biosynthetic process|neuron projection|positive regulation of fat cell differentiation|indolalkylamine biosynthetic process|bone remodeling|oxidation-reduction process|mammary gland alveolus development "hsa00380,hsa00790,hsa04726" Tryptophan metabolism|Folate biosynthesis|Serotonergic synapse TPI1 20094.37335 24310.22535 15878.52134 0.653162244 -0.614486697 0.092409057 1 659.4682126 449.2942583 7167 triosephosphate isomerase 1 "GO:0004807,GO:0005515,GO:0005615,GO:0005634,GO:0005829,GO:0006094,GO:0006096,GO:0007275,GO:0008929,GO:0019242,GO:0019563,GO:0031625,GO:0042803,GO:0046166,GO:0061621,GO:0070062" triose-phosphate isomerase activity|protein binding|extracellular space|nucleus|cytosol|gluconeogenesis|glycolytic process|multicellular organism development|methylglyoxal synthase activity|methylglyoxal biosynthetic process|glycerol catabolic process|ubiquitin protein ligase binding|protein homodimerization activity|glyceraldehyde-3-phosphate biosynthetic process|canonical glycolysis|extracellular exosome "hsa00010,hsa00051,hsa00562" Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Inositol phosphate metabolism TPK1 91.66596326 103.5255088 79.80641774 0.770886506 -0.37540962 0.59726895 1 0.414154961 0.333019175 27010 thiamin pyrophosphokinase 1 "GO:0004788,GO:0005515,GO:0005524,GO:0005829,GO:0006772,GO:0009229,GO:0016301,GO:0016310,GO:0030975,GO:0042723,GO:0042802" thiamine diphosphokinase activity|protein binding|ATP binding|cytosol|thiamine metabolic process|thiamine diphosphate biosynthetic process|kinase activity|phosphorylation|thiamine binding|thiamine-containing compound metabolic process|identical protein binding hsa00730 Thiamine metabolism TPM1 2333.665834 2665.274373 2002.057294 0.751163676 -0.412800795 0.196794076 1 34.03599205 26.66790637 7168 tropomyosin 1 "GO:0001725,GO:0003065,GO:0003779,GO:0005200,GO:0005515,GO:0005829,GO:0005856,GO:0005862,GO:0005884,GO:0006936,GO:0006937,GO:0007010,GO:0007015,GO:0008016,GO:0008092,GO:0008307,GO:0008360,GO:0015629,GO:0030017,GO:0030049,GO:0030336,GO:0031529,GO:0032059,GO:0032587,GO:0032781,GO:0034614,GO:0042060,GO:0042802,GO:0042803,GO:0045214,GO:0045785,GO:0046982,GO:0051015,GO:0051496,GO:0055010,GO:0060048,GO:1904706,GO:1904753" stress fiber|positive regulation of heart rate by epinephrine|actin binding|structural constituent of cytoskeleton|protein binding|cytosol|cytoskeleton|muscle thin filament tropomyosin|actin filament|muscle contraction|regulation of muscle contraction|cytoskeleton organization|actin filament organization|regulation of heart contraction|cytoskeletal protein binding|structural constituent of muscle|regulation of cell shape|actin cytoskeleton|sarcomere|muscle filament sliding|negative regulation of cell migration|ruffle organization|bleb|ruffle membrane|positive regulation of ATPase activity|cellular response to reactive oxygen species|wound healing|identical protein binding|protein homodimerization activity|sarcomere organization|positive regulation of cell adhesion|protein heterodimerization activity|actin filament binding|positive regulation of stress fiber assembly|ventricular cardiac muscle tissue morphogenesis|cardiac muscle contraction|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of vascular associated smooth muscle cell migration "hsa04260,hsa04261,hsa05206,hsa05410,hsa05414" Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|MicroRNAs in cancer|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TPM2 6530.83288 6702.769215 6358.896544 0.948696925 -0.075980824 0.816039962 1 183.9954552 182.0750838 7169 tropomyosin 2 "GO:0003779,GO:0005829,GO:0005862,GO:0005884,GO:0006936,GO:0007015,GO:0008307,GO:0015629,GO:0030049,GO:0042802,GO:0042803,GO:0043462,GO:0046982,GO:0051015" actin binding|cytosol|muscle thin filament tropomyosin|actin filament|muscle contraction|actin filament organization|structural constituent of muscle|actin cytoskeleton|muscle filament sliding|identical protein binding|protein homodimerization activity|regulation of ATPase activity|protein heterodimerization activity|actin filament binding "hsa04260,hsa04261,hsa05410,hsa05414" Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TPM3 11082.69091 10975.73384 11189.64798 1.019489734 0.027847248 0.934883682 1 56.28616839 59.85500514 7170 tropomyosin 3 "GO:0001725,GO:0003674,GO:0005515,GO:0005829,GO:0005856,GO:0005862,GO:0005884,GO:0006936,GO:0007015,GO:0015629,GO:0030049,GO:0051015,GO:0070062" stress fiber|molecular_function|protein binding|cytosol|cytoskeleton|muscle thin filament tropomyosin|actin filament|muscle contraction|actin filament organization|actin cytoskeleton|muscle filament sliding|actin filament binding|extracellular exosome "hsa04260,hsa04261,hsa05200,hsa05216,hsa05410,hsa05414" Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Pathways in cancer|Thyroid cancer|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TPM4 10342.0529 10826.53531 9857.570488 0.910500931 -0.135267602 0.68859688 1 82.24476076 78.10962733 7171 tropomyosin 4 "GO:0001649,GO:0001725,GO:0005509,GO:0005515,GO:0005829,GO:0005856,GO:0005862,GO:0005884,GO:0005925,GO:0006936,GO:0007015,GO:0008307,GO:0016020,GO:0030049,GO:0042802,GO:0042803,GO:0046982,GO:0051015,GO:0070062" osteoblast differentiation|stress fiber|calcium ion binding|protein binding|cytosol|cytoskeleton|muscle thin filament tropomyosin|actin filament|focal adhesion|muscle contraction|actin filament organization|structural constituent of muscle|membrane|muscle filament sliding|identical protein binding|protein homodimerization activity|protein heterodimerization activity|actin filament binding|extracellular exosome "hsa04260,hsa04261,hsa05410,hsa05414" Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TPMT 223.8262448 281.1428032 166.5096864 0.592260177 -0.755697011 0.146383641 1 3.996320845 2.468816494 7172 thiopurine S-methyltransferase "GO:0005515,GO:0005829,GO:0006139,GO:0008119,GO:0017144,GO:0032259,GO:1904047" protein binding|cytosol|nucleobase-containing compound metabolic process|thiopurine S-methyltransferase activity|drug metabolic process|methylation|S-adenosyl-L-methionine binding hsa00983 Drug metabolism - other enzymes TPP1 4837.352383 6580.974499 3093.730268 0.470102151 -1.088953813 0.000777202 0.079140395 95.44763519 46.80296221 1200 tripeptidyl peptidase 1 "GO:0004175,GO:0004252,GO:0005515,GO:0005764,GO:0005794,GO:0006508,GO:0006629,GO:0007040,GO:0007399,GO:0007417,GO:0008233,GO:0008236,GO:0008240,GO:0030163,GO:0030855,GO:0035727,GO:0036498,GO:0042277,GO:0042470,GO:0043171,GO:0043202,GO:0045121,GO:0045453,GO:0046872,GO:0050885,GO:0055037,GO:0070062,GO:0070198,GO:0120146,GO:1905146" "endopeptidase activity|serine-type endopeptidase activity|protein binding|lysosome|Golgi apparatus|proteolysis|lipid metabolic process|lysosome organization|nervous system development|central nervous system development|peptidase activity|serine-type peptidase activity|tripeptidyl-peptidase activity|protein catabolic process|epithelial cell differentiation|lysophosphatidic acid binding|IRE1-mediated unfolded protein response|peptide binding|melanosome|peptide catabolic process|lysosomal lumen|membrane raft|bone resorption|metal ion binding|neuromuscular process controlling balance|recycling endosome|extracellular exosome|protein localization to chromosome, telomeric region|sulfatide binding|lysosomal protein catabolic process" hsa04142 Lysosome TPP2 1263.773582 1190.543351 1337.003813 1.123019848 0.167383426 0.622862273 1 10.74618085 12.58802239 7174 tripeptidyl peptidase 2 "GO:0000209,GO:0004175,GO:0004177,GO:0004252,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006508,GO:0008240,GO:0016604,GO:0042802" protein polyubiquitination|endopeptidase activity|aminopeptidase activity|serine-type endopeptidase activity|protein binding|nucleoplasm|cytoplasm|cytosol|proteolysis|tripeptidyl-peptidase activity|nuclear body|identical protein binding TPPP 29.52551934 31.46363502 27.58740366 0.876802812 -0.18967567 0.880284265 1 0.186180876 0.170275801 11076 tubulin polymerization promoting protein "GO:0000287,GO:0001578,GO:0003924,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0008017,GO:0014003,GO:0015631,GO:0030953,GO:0031334,GO:0031643,GO:0032273,GO:0032288,GO:0042803,GO:0046785,GO:0048471,GO:0048709,GO:0051301,GO:0051418,GO:0070507,GO:0072686,GO:0097427,GO:0150051,GO:1904428" magnesium ion binding|microtubule bundle formation|GTPase activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|microtubule|microtubule binding|oligodendrocyte development|tubulin binding|astral microtubule organization|positive regulation of protein-containing complex assembly|positive regulation of myelination|positive regulation of protein polymerization|myelin assembly|protein homodimerization activity|microtubule polymerization|perinuclear region of cytoplasm|oligodendrocyte differentiation|cell division|microtubule nucleation by microtubule organizing center|regulation of microtubule cytoskeleton organization|mitotic spindle|microtubule bundle|postsynaptic Golgi apparatus|negative regulation of tubulin deacetylation TPR 5797.304506 5220.933501 6373.675511 1.220792318 0.287817789 0.374049305 1 27.44104021 34.94284709 7175 "translocated promoter region, nuclear basket protein" "GO:0000122,GO:0000776,GO:0003682,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0005868,GO:0006110,GO:0006404,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0006611,GO:0006999,GO:0007094,GO:0010793,GO:0010965,GO:0015631,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0019898,GO:0031072,GO:0031453,GO:0031647,GO:0031965,GO:0031990,GO:0032880,GO:0034399,GO:0034605,GO:0035457,GO:0042306,GO:0042307,GO:0042405,GO:0042803,GO:0043495,GO:0043578,GO:0043657,GO:0044615,GO:0045947,GO:0046825,GO:0046827,GO:0046832,GO:0051019,GO:0051292,GO:0051301,GO:0060964,GO:0070840,GO:0070849,GO:0072686,GO:0075733,GO:0090267,GO:0090316,GO:1900034,GO:1901673" negative regulation of transcription by RNA polymerase II|kinetochore|chromatin binding|RNA binding|mRNA binding|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|cytoplasmic dynein complex|regulation of glycolytic process|RNA import into nucleus|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|protein export from nucleus|nuclear pore organization|mitotic spindle assembly checkpoint|regulation of mRNA export from nucleus|regulation of mitotic sister chromatid separation|tubulin binding|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|extrinsic component of membrane|heat shock protein binding|positive regulation of heterochromatin assembly|regulation of protein stability|nuclear membrane|mRNA export from nucleus in response to heat stress|regulation of protein localization|nuclear periphery|cellular response to heat|cellular response to interferon-alpha|regulation of protein import into nucleus|positive regulation of protein import into nucleus|nuclear inclusion body|protein homodimerization activity|protein-membrane adaptor activity|nuclear matrix organization|host cell|nuclear pore nuclear basket|negative regulation of translational initiation|regulation of protein export from nucleus|positive regulation of protein export from nucleus|negative regulation of RNA export from nucleus|mitogen-activated protein kinase binding|nuclear pore complex assembly|cell division|regulation of gene silencing by miRNA|dynein complex binding|response to epidermal growth factor|mitotic spindle|intracellular transport of virus|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of intracellular protein transport|regulation of cellular response to heat|regulation of mitotic spindle assembly "hsa03013,hsa05014,hsa05200,hsa05216" RNA transport|Amyotrophic lateral sclerosis|Pathways in cancer|Thyroid cancer TPRA1 786.9882442 724.6785614 849.2979271 1.171965023 0.228929514 0.535597904 1 7.118388794 8.70186387 131601 transmembrane protein adipocyte associated 1 "GO:0004930,GO:0005515,GO:0006629,GO:0007186,GO:0007568,GO:0016021,GO:0040016,GO:1901991" G protein-coupled receptor activity|protein binding|lipid metabolic process|G protein-coupled receptor signaling pathway|aging|integral component of membrane|embryonic cleavage|negative regulation of mitotic cell cycle phase transition TPRG1L 755.1304542 735.8430771 774.4178314 1.052422528 0.073714036 0.845890126 1 15.5218059 17.03916521 127262 tumor protein p63 regulated 1 like "GO:0003674,GO:0005737,GO:0008021,GO:0008150,GO:0030672,GO:0042802,GO:0044305,GO:0048786,GO:0051966,GO:0070062" "molecular_function|cytoplasm|synaptic vesicle|biological_process|synaptic vesicle membrane|identical protein binding|calyx of Held|presynaptic active zone|regulation of synaptic transmission, glutamatergic|extracellular exosome" TPRKB 385.6416983 364.3691926 406.914204 1.11676347 0.159323656 0.720014452 1 19.00516394 22.13852844 51002 TP53RK binding protein "GO:0000408,GO:0000722,GO:0002949,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0019901" EKC/KEOPS complex|telomere maintenance via recombination|tRNA threonylcarbamoyladenosine modification|protein binding|nucleus|cytoplasm|cytosol|protein kinase binding TPRN 403.3049506 325.8008658 480.8090353 1.475775806 0.561473569 0.194673019 1 6.205590259 9.552552046 286262 taperin "GO:0003674,GO:0005515,GO:0007605,GO:0019902,GO:0032420,GO:0060088,GO:0120044,GO:0120045" molecular_function|protein binding|sensory perception of sound|phosphatase binding|stereocilium|auditory receptor cell stereocilium organization|stereocilium base|stereocilium maintenance TPST1 550.734109 536.9117073 564.5565107 1.051488547 0.072433135 0.860037175 1 8.431839957 9.247893738 8460 tyrosylprotein sulfotransferase 1 "GO:0000139,GO:0005794,GO:0006478,GO:0006954,GO:0008146,GO:0008476,GO:0016020,GO:0018215,GO:0030173,GO:0042803,GO:0050427" Golgi membrane|Golgi apparatus|peptidyl-tyrosine sulfation|inflammatory response|sulfotransferase activity|protein-tyrosine sulfotransferase activity|membrane|protein phosphopantetheinylation|integral component of Golgi membrane|protein homodimerization activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process TPST2 625.1700691 674.945719 575.3944193 0.852504732 -0.230220253 0.553617787 1 5.748044325 5.111317236 8459 tyrosylprotein sulfotransferase 2 "GO:0000139,GO:0005783,GO:0005794,GO:0006478,GO:0008146,GO:0008476,GO:0016021,GO:0018215,GO:0042803,GO:0050427" Golgi membrane|endoplasmic reticulum|Golgi apparatus|peptidyl-tyrosine sulfation|sulfotransferase activity|protein-tyrosine sulfotransferase activity|integral component of membrane|protein phosphopantetheinylation|protein homodimerization activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process TPT1 30477.9736 28681.64071 32274.30649 1.125260121 0.170258541 0.662625264 1 308.2164055 361.7633851 7178 "tumor protein, translationally-controlled 1" "GO:0000922,GO:0003723,GO:0005509,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005771,GO:0005829,GO:0005881,GO:0006816,GO:0006874,GO:0009615,GO:0042981,GO:0043066,GO:0070062,GO:1902230" spindle pole|RNA binding|calcium ion binding|protein binding|extracellular space|nucleus|cytoplasm|multivesicular body|cytosol|cytoplasmic microtubule|calcium ion transport|cellular calcium ion homeostasis|response to virus|regulation of apoptotic process|negative regulation of apoptotic process|extracellular exosome|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage TPTEP2-CSNK1E 56.49880299 56.83753423 56.16007174 0.98808072 -0.017299189 1 1 0.849150619 0.875171337 102800317 TPTEP2-CSNK1E readthrough "hsa04068,hsa04310,hsa04340,hsa04390,hsa04392,hsa04710,hsa05010,hsa05022" FoxO signaling pathway|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species|Circadian rhythm|Alzheimer disease|Pathways of neurodegeneration - multiple diseases TPX2 7615.139135 6973.762459 8256.515811 1.183939926 0.24359588 0.459717157 1 100.4826363 124.0899522 22974 TPX2 microtubule nucleation factor "GO:0000278,GO:0000922,GO:0005515,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005880,GO:0006915,GO:0007020,GO:0007026,GO:0008017,GO:0010389,GO:0015630,GO:0019901,GO:0030295,GO:0032147,GO:0043203,GO:0045171,GO:0051301,GO:0060236,GO:0061676,GO:0072686,GO:0090307,GO:1901796" mitotic cell cycle|spindle pole|protein binding|nucleus|nucleoplasm|spindle|cytosol|nuclear microtubule|apoptotic process|microtubule nucleation|negative regulation of microtubule depolymerization|microtubule binding|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|protein kinase binding|protein kinase activator activity|activation of protein kinase activity|axon hillock|intercellular bridge|cell division|regulation of mitotic spindle organization|importin-alpha family protein binding|mitotic spindle|mitotic spindle assembly|regulation of signal transduction by p53 class mediator TRA2A 1285.659716 1541.718116 1029.601315 0.667827215 -0.582453209 0.085741268 1 35.70305611 24.87055262 29896 transformer 2 alpha homolog "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0043231,GO:0048026" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|intracellular membrane-bounded organelle|positive regulation of mRNA splicing, via spliceosome" hsa03040 Spliceosome TRA2B 3008.100361 3508.702783 2507.49794 0.714650997 -0.484689229 0.128068661 1 32.66006579 24.34596474 6434 transformer 2 beta homolog "GO:0000302,GO:0000375,GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005637,GO:0005654,GO:0005681,GO:0019904,GO:0021796,GO:0032991,GO:0036002,GO:0042802,GO:0043484,GO:0048026,GO:0048471,GO:0071333,GO:1990403" "response to reactive oxygen species|RNA splicing, via transesterification reactions|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nuclear inner membrane|nucleoplasm|spliceosomal complex|protein domain specific binding|cerebral cortex regionalization|protein-containing complex|pre-mRNA binding|identical protein binding|regulation of RNA splicing|positive regulation of mRNA splicing, via spliceosome|perinuclear region of cytoplasm|cellular response to glucose stimulus|embryonic brain development" hsa03040 Spliceosome TRABD 1157.860379 1157.049804 1158.670954 1.001401106 0.002019955 0.998198115 1 28.32309847 29.58453578 80305 TraB domain containing TRABD2A 199.3485354 224.305269 174.3918017 0.77747528 -0.363131291 0.503626699 1 2.662355419 2.15907909 129293 TraB domain containing 2A "GO:0004175,GO:0004222,GO:0005887,GO:0006508,GO:0016020,GO:0016055,GO:0017147,GO:0030178,GO:0031301,GO:0031334,GO:0046872,GO:0060322,GO:1904808" endopeptidase activity|metalloendopeptidase activity|integral component of plasma membrane|proteolysis|membrane|Wnt signaling pathway|Wnt-protein binding|negative regulation of Wnt signaling pathway|integral component of organelle membrane|positive regulation of protein-containing complex assembly|metal ion binding|head development|positive regulation of protein oxidation TRADD 275.7186518 258.8137719 292.6235317 1.130633542 0.177131403 0.720218786 1 8.022034583 9.460679389 8717 TNFRSF1A associated via death domain "GO:0002947,GO:0005068,GO:0005164,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006915,GO:0006919,GO:0007165,GO:0007169,GO:0007249,GO:0008625,GO:0010803,GO:0019900,GO:0030335,GO:0031264,GO:0033209,GO:0042802,GO:0043065,GO:0043123,GO:0043235,GO:0044877,GO:0045121,GO:0050729,GO:0051092,GO:0051798,GO:0070513,GO:0071356,GO:0071550,GO:0097191,GO:1901224,GO:1902041,GO:1902042" tumor necrosis factor receptor superfamily complex|transmembrane receptor protein tyrosine kinase adaptor activity|tumor necrosis factor receptor binding|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|I-kappaB kinase/NF-kappaB signaling|extrinsic apoptotic signaling pathway via death domain receptors|regulation of tumor necrosis factor-mediated signaling pathway|kinase binding|positive regulation of cell migration|death-inducing signaling complex|tumor necrosis factor-mediated signaling pathway|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|protein-containing complex binding|membrane raft|positive regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|positive regulation of hair follicle development|death domain binding|cellular response to tumor necrosis factor|death-inducing signaling complex assembly|extrinsic apoptotic signaling pathway|positive regulation of NIK/NF-kappaB signaling|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors "hsa04010,hsa04064,hsa04071,hsa04210,hsa04217,hsa04622,hsa04657,hsa04668,hsa04920,hsa05130,hsa05131,hsa05132,hsa05152,hsa05160,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203" MAPK signaling pathway|NF-kappa B signaling pathway|Sphingolipid signaling pathway|Apoptosis|Necroptosis|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Tuberculosis|Hepatitis C|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis TRAF1 157.0469918 161.377999 152.7159846 0.946324688 -0.079592831 0.90218963 1 1.82234701 1.798817809 7185 TNF receptor associated factor 1 "GO:0005164,GO:0005515,GO:0005737,GO:0005829,GO:0006915,GO:0008270,GO:0009898,GO:0010803,GO:0031625,GO:0031996,GO:0033209,GO:0042802,GO:0043122,GO:0046330,GO:0051092,GO:0065003,GO:0070534,GO:0098802,GO:2001236" tumor necrosis factor receptor binding|protein binding|cytoplasm|cytosol|apoptotic process|zinc ion binding|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|ubiquitin protein ligase binding|thioesterase binding|tumor necrosis factor-mediated signaling pathway|identical protein binding|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein-containing complex assembly|protein K63-linked ubiquitination|plasma membrane signaling receptor complex|regulation of extrinsic apoptotic signaling pathway "hsa04064,hsa04210,hsa04668,hsa05200,hsa05202,hsa05203,hsa05222" NF-kappa B signaling pathway|Apoptosis|TNF signaling pathway|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Small cell lung cancer TRAF2 832.2577053 822.1143344 842.4010761 1.024676302 0.035168231 0.926493924 1 12.33694542 13.18591481 7186 TNF receptor associated factor 2 "GO:0000151,GO:0002637,GO:0002726,GO:0002947,GO:0004842,GO:0005164,GO:0005174,GO:0005515,GO:0005654,GO:0005829,GO:0005938,GO:0006919,GO:0007165,GO:0007249,GO:0007250,GO:0008270,GO:0009898,GO:0010803,GO:0012506,GO:0016579,GO:0019899,GO:0019901,GO:0019903,GO:0030163,GO:0030674,GO:0031435,GO:0031625,GO:0031996,GO:0032743,GO:0033209,GO:0034351,GO:0034622,GO:0034976,GO:0035631,GO:0042802,GO:0042981,GO:0043120,GO:0043122,GO:0043123,GO:0043254,GO:0043507,GO:0044877,GO:0045121,GO:0046330,GO:0046625,GO:0051091,GO:0051092,GO:0051865,GO:0065003,GO:0070059,GO:0070534,GO:0071550,GO:0071732,GO:0097057,GO:0097300,GO:0098802,GO:1901215,GO:1902041,GO:1902042,GO:1903265,GO:1903721,GO:1990604,GO:2001238" ubiquitin ligase complex|regulation of immunoglobulin production|positive regulation of T cell cytokine production|tumor necrosis factor receptor superfamily complex|ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|CD40 receptor binding|protein binding|nucleoplasm|cytosol|cell cortex|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|I-kappaB kinase/NF-kappaB signaling|activation of NF-kappaB-inducing kinase activity|zinc ion binding|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|vesicle membrane|protein deubiquitination|enzyme binding|protein kinase binding|protein phosphatase binding|protein catabolic process|protein-macromolecule adaptor activity|mitogen-activated protein kinase kinase kinase binding|ubiquitin protein ligase binding|thioesterase binding|positive regulation of interleukin-2 production|tumor necrosis factor-mediated signaling pathway|negative regulation of glial cell apoptotic process|cellular protein-containing complex assembly|response to endoplasmic reticulum stress|CD40 receptor complex|identical protein binding|regulation of apoptotic process|tumor necrosis factor binding|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of protein-containing complex assembly|positive regulation of JUN kinase activity|protein-containing complex binding|membrane raft|positive regulation of JNK cascade|sphingolipid binding|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|protein-containing complex assembly|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|protein K63-linked ubiquitination|death-inducing signaling complex assembly|cellular response to nitric oxide|TRAF2-GSTP1 complex|programmed necrotic cell death|plasma membrane signaling receptor complex|negative regulation of neuron death|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of I-kappaB phosphorylation|IRE1-TRAF2-ASK1 complex|positive regulation of extrinsic apoptotic signaling pathway "hsa04010,hsa04064,hsa04071,hsa04141,hsa04210,hsa04217,hsa04380,hsa04621,hsa04622,hsa04657,hsa04668,hsa04920,hsa04932,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05130,hsa05131,hsa05132,hsa05135,hsa05160,hsa05163,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05222" MAPK signaling pathway|NF-kappa B signaling pathway|Sphingolipid signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Hepatitis C|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer TRAF3 2241.81504 2448.073796 2035.556285 0.831493024 -0.266223934 0.405809226 1 11.54649855 10.01439795 7187 TNF receptor associated factor 3 "GO:0001817,GO:0002224,GO:0004842,GO:0005164,GO:0005515,GO:0005739,GO:0005768,GO:0005829,GO:0006915,GO:0007165,GO:0008063,GO:0008270,GO:0009898,GO:0016579,GO:0019901,GO:0019903,GO:0030162,GO:0031625,GO:0031996,GO:0032088,GO:0032648,GO:0033209,GO:0035631,GO:0035666,GO:0042802,GO:0042981,GO:0043122,GO:0045087,GO:0046330,GO:0050688,GO:0070534,GO:0098802" regulation of cytokine production|toll-like receptor signaling pathway|ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|protein binding|mitochondrion|endosome|cytosol|apoptotic process|signal transduction|Toll signaling pathway|zinc ion binding|cytoplasmic side of plasma membrane|protein deubiquitination|protein kinase binding|protein phosphatase binding|regulation of proteolysis|ubiquitin protein ligase binding|thioesterase binding|negative regulation of NF-kappaB transcription factor activity|regulation of interferon-beta production|tumor necrosis factor-mediated signaling pathway|CD40 receptor complex|TRIF-dependent toll-like receptor signaling pathway|identical protein binding|regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of JNK cascade|regulation of defense response to virus|protein K63-linked ubiquitination|plasma membrane signaling receptor complex "hsa04064,hsa04620,hsa04621,hsa04622,hsa04657,hsa04668,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200,hsa05203,hsa05222" NF-kappa B signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer TRAF3IP1 435.72688 353.204677 518.2490831 1.467276955 0.553141212 0.191790287 1 3.889665331 5.953060037 26146 TRAF3 interacting protein 1 "GO:0001738,GO:0001822,GO:0001933,GO:0005515,GO:0005813,GO:0005929,GO:0005930,GO:0008017,GO:0030992,GO:0031333,GO:0032480,GO:0035735,GO:0035869,GO:0036064,GO:0042073,GO:0050687,GO:0060271,GO:0070507,GO:0097542,GO:0097546" morphogenesis of a polarized epithelium|kidney development|negative regulation of protein phosphorylation|protein binding|centrosome|cilium|axoneme|microtubule binding|intraciliary transport particle B|negative regulation of protein-containing complex assembly|negative regulation of type I interferon production|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|intraciliary transport|negative regulation of defense response to virus|cilium assembly|regulation of microtubule cytoskeleton organization|ciliary tip|ciliary base TRAF3IP2 348.7415417 333.9205136 363.5625697 1.088769797 0.122698951 0.790715636 1 2.814896141 3.196791929 10758 TRAF3 interacting protein 2 "GO:0001783,GO:0002230,GO:0005102,GO:0005515,GO:0005575,GO:0006954,GO:0006959,GO:0035556,GO:0043123,GO:0061630,GO:0070534,GO:0097400" B cell apoptotic process|positive regulation of defense response to virus by host|signaling receptor binding|protein binding|cellular_component|inflammatory response|humoral immune response|intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin protein ligase activity|protein K63-linked ubiquitination|interleukin-17-mediated signaling pathway "hsa04218,hsa04657" Cellular senescence|IL-17 signaling pathway TRAF4 1453.029219 1432.102871 1473.955567 1.029224643 0.041557906 0.902630765 1 17.71640407 19.01961331 9618 TNF receptor associated factor 4 "GO:0001650,GO:0005164,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005923,GO:0006915,GO:0007250,GO:0007585,GO:0008270,GO:0019901,GO:0030323,GO:0031625,GO:0031996,GO:0033209,GO:0042802,GO:0042981,GO:0043122,GO:0045860,GO:0046330,GO:0048471,GO:0050699,GO:0070534,GO:0098802" fibrillar center|tumor necrosis factor receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|bicellular tight junction|apoptotic process|activation of NF-kappaB-inducing kinase activity|respiratory gaseous exchange by respiratory system|zinc ion binding|protein kinase binding|respiratory tube development|ubiquitin protein ligase binding|thioesterase binding|tumor necrosis factor-mediated signaling pathway|identical protein binding|regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of protein kinase activity|positive regulation of JNK cascade|perinuclear region of cytoplasm|WW domain binding|protein K63-linked ubiquitination|plasma membrane signaling receptor complex "hsa04657,hsa05200,hsa05222" IL-17 signaling pathway|Pathways in cancer|Small cell lung cancer TRAF5 734.7719518 691.1850145 778.3588891 1.126122345 0.171363574 0.64848256 1 4.82044652 5.662246534 7188 TNF receptor associated factor 5 "GO:0004842,GO:0005164,GO:0005515,GO:0005813,GO:0005829,GO:0006915,GO:0007165,GO:0008270,GO:0008284,GO:0009898,GO:0031625,GO:0031996,GO:0033209,GO:0035631,GO:0042802,GO:0042981,GO:0043122,GO:0043123,GO:0046330,GO:0051091,GO:0051092,GO:0070534,GO:0098802" ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|protein binding|centrosome|cytosol|apoptotic process|signal transduction|zinc ion binding|positive regulation of cell population proliferation|cytoplasmic side of plasma membrane|ubiquitin protein ligase binding|thioesterase binding|tumor necrosis factor-mediated signaling pathway|CD40 receptor complex|identical protein binding|regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein K63-linked ubiquitination|plasma membrane signaling receptor complex "hsa04064,hsa04217,hsa04621,hsa04657,hsa04668,hsa05131,hsa05163,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05222" NF-kappa B signaling pathway|Necroptosis|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Shigellosis|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer TRAF6 352.1454298 330.8756457 373.4152139 1.128566634 0.174491603 0.702156129 1 1.757860505 2.069319474 7189 TNF receptor associated factor 6 "GO:0000122,GO:0000187,GO:0000209,GO:0001503,GO:0001701,GO:0001843,GO:0002223,GO:0002224,GO:0002637,GO:0002726,GO:0002755,GO:0004842,GO:0005164,GO:0005515,GO:0005634,GO:0005737,GO:0005811,GO:0005829,GO:0005886,GO:0005938,GO:0006974,GO:0007249,GO:0007250,GO:0007254,GO:0008270,GO:0009898,GO:0010008,GO:0016579,GO:0019886,GO:0019901,GO:0030316,GO:0031293,GO:0031398,GO:0031435,GO:0031624,GO:0031625,GO:0031666,GO:0031996,GO:0032147,GO:0032735,GO:0032743,GO:0032755,GO:0032991,GO:0033209,GO:0034162,GO:0035631,GO:0038095,GO:0042088,GO:0042102,GO:0042475,GO:0042802,GO:0042826,GO:0043011,GO:0043065,GO:0043066,GO:0043122,GO:0043123,GO:0043422,GO:0043507,GO:0045453,GO:0045672,GO:0045892,GO:0045944,GO:0046330,GO:0047485,GO:0048468,GO:0048471,GO:0048661,GO:0050852,GO:0051091,GO:0051092,GO:0051865,GO:0061630,GO:0070423,GO:0070498,GO:0070534,GO:0070555,GO:0071222,GO:0071345,GO:0098802,GO:1901224,GO:1904996,GO:2000679" "negative regulation of transcription by RNA polymerase II|activation of MAPK activity|protein polyubiquitination|ossification|in utero embryonic development|neural tube closure|stimulatory C-type lectin receptor signaling pathway|toll-like receptor signaling pathway|regulation of immunoglobulin production|positive regulation of T cell cytokine production|MyD88-dependent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|protein binding|nucleus|cytoplasm|lipid droplet|cytosol|plasma membrane|cell cortex|cellular response to DNA damage stimulus|I-kappaB kinase/NF-kappaB signaling|activation of NF-kappaB-inducing kinase activity|JNK cascade|zinc ion binding|cytoplasmic side of plasma membrane|endosome membrane|protein deubiquitination|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|osteoclast differentiation|membrane protein intracellular domain proteolysis|positive regulation of protein ubiquitination|mitogen-activated protein kinase kinase kinase binding|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|positive regulation of lipopolysaccharide-mediated signaling pathway|thioesterase binding|activation of protein kinase activity|positive regulation of interleukin-12 production|positive regulation of interleukin-2 production|positive regulation of interleukin-6 production|protein-containing complex|tumor necrosis factor-mediated signaling pathway|toll-like receptor 9 signaling pathway|CD40 receptor complex|Fc-epsilon receptor signaling pathway|T-helper 1 type immune response|positive regulation of T cell proliferation|odontogenesis of dentin-containing tooth|identical protein binding|histone deacetylase binding|myeloid dendritic cell differentiation|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein kinase B binding|positive regulation of JUN kinase activity|bone resorption|positive regulation of osteoclast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|protein N-terminus binding|cell development|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|T cell receptor signaling pathway|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|ubiquitin protein ligase activity|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination|response to interleukin-1|cellular response to lipopolysaccharide|cellular response to cytokine stimulus|plasma membrane signaling receptor complex|positive regulation of NIK/NF-kappaB signaling|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of transcription regulatory region DNA binding" "hsa04010,hsa04064,hsa04120,hsa04140,hsa04144,hsa04380,hsa04620,hsa04621,hsa04622,hsa04657,hsa04722,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05222,hsa05235" MAPK signaling pathway|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Autophagy - animal|Endocytosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|Neurotrophin signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer TRAF7 2480.192367 2410.520425 2549.86431 1.057806556 0.081075823 0.800354074 1 32.91570658 36.31828786 84231 TNF receptor associated factor 7 "GO:0000027,GO:0000151,GO:0000185,GO:0004842,GO:0005515,GO:0005730,GO:0005886,GO:0006915,GO:0007219,GO:0008270,GO:0016567,GO:0031410,GO:0043231,GO:0043410,GO:0070372,GO:2001235" ribosomal large subunit assembly|ubiquitin ligase complex|activation of MAPKKK activity|ubiquitin-protein transferase activity|protein binding|nucleolus|plasma membrane|apoptotic process|Notch signaling pathway|zinc ion binding|protein ubiquitination|cytoplasmic vesicle|intracellular membrane-bounded organelle|positive regulation of MAPK cascade|regulation of ERK1 and ERK2 cascade|positive regulation of apoptotic signaling pathway TRAFD1 611.5626814 586.6445497 636.4808131 1.084951379 0.117630391 0.765524106 1 11.28426771 12.77025551 10906 TRAF-type zinc finger domain containing 1 "GO:0005515,GO:0045824,GO:0046872" protein binding|negative regulation of innate immune response|metal ion binding TRAIP 385.4365791 316.6662621 454.206896 1.434339399 0.52038644 0.235424135 1 7.904400712 11.82597091 10293 TRAF interacting protein "GO:0004842,GO:0005515,GO:0005654,GO:0005730,GO:0006915,GO:0006974,GO:0007165,GO:0010804,GO:0016567,GO:0031297,GO:0032088,GO:0032688,GO:0042802,GO:0046872,GO:0048471,GO:0061630,GO:0090734,GO:0106300" ubiquitin-protein transferase activity|protein binding|nucleoplasm|nucleolus|apoptotic process|cellular response to DNA damage stimulus|signal transduction|negative regulation of tumor necrosis factor-mediated signaling pathway|protein ubiquitination|replication fork processing|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-beta production|identical protein binding|metal ion binding|perinuclear region of cytoplasm|ubiquitin protein ligase activity|site of DNA damage|protein-DNA covalent cross-linking repair TRAK1 1451.940034 1424.99818 1478.881889 1.037813178 0.05354676 0.874081297 1 8.725804704 9.445840312 22906 trafficking kinesin protein 1 "GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005769,GO:0005938,GO:0006357,GO:0006493,GO:0006605,GO:0008333,GO:0017022,GO:0022008,GO:0030425,GO:0031410,GO:0031966,GO:0047496,GO:0048311,GO:0050811,GO:0098957,GO:1904115" signaling receptor binding|protein binding|nucleus|cytoplasm|mitochondrion|early endosome|cell cortex|regulation of transcription by RNA polymerase II|protein O-linked glycosylation|protein targeting|endosome to lysosome transport|myosin binding|neurogenesis|dendrite|cytoplasmic vesicle|mitochondrial membrane|vesicle transport along microtubule|mitochondrion distribution|GABA receptor binding|anterograde axonal transport of mitochondrion|axon cytoplasm TRAK2 1070.849308 1270.724872 870.9737442 0.685414887 -0.544950569 0.118014924 1 9.931748756 7.100602271 66008 trafficking kinesin protein 2 "GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005769,GO:0005886,GO:0006357,GO:0006493,GO:0006605,GO:0008333,GO:0017022,GO:0019894,GO:0019899,GO:0022008,GO:0030425,GO:0030911,GO:0031410,GO:0032839,GO:0043025,GO:0044295,GO:0047496,GO:0048311,GO:0048813,GO:0050771,GO:0050811,GO:0098957,GO:0098972,GO:1904115" signaling receptor binding|protein binding|nucleus|cytoplasm|mitochondrion|early endosome|plasma membrane|regulation of transcription by RNA polymerase II|protein O-linked glycosylation|protein targeting|endosome to lysosome transport|myosin binding|kinesin binding|enzyme binding|neurogenesis|dendrite|TPR domain binding|cytoplasmic vesicle|dendrite cytoplasm|neuronal cell body|axonal growth cone|vesicle transport along microtubule|mitochondrion distribution|dendrite morphogenesis|negative regulation of axonogenesis|GABA receptor binding|anterograde axonal transport of mitochondrion|anterograde dendritic transport of mitochondrion|axon cytoplasm hsa04727 GABAergic synapse TRAM1 4704.191246 5492.941701 3915.440791 0.712813098 -0.488404248 0.127801133 1 76.70199041 57.0293255 23471 translocation associated membrane protein 1 "GO:0005515,GO:0005783,GO:0006613,GO:0006616,GO:0016021,GO:0016032,GO:0030176,GO:0038023,GO:0045048" "protein binding|endoplasmic reticulum|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane, translocation|integral component of membrane|viral process|integral component of endoplasmic reticulum membrane|signaling receptor activity|protein insertion into ER membrane" hsa04141 Protein processing in endoplasmic reticulum TRAM1L1 59.24403377 76.12169763 42.36636991 0.556561023 -0.845388217 0.295007598 1 1.905731806 1.106344804 133022 translocation associated membrane protein 1 like 1 "GO:0005515,GO:0006616,GO:0030176,GO:0045048" "protein binding|SRP-dependent cotranslational protein targeting to membrane, translocation|integral component of endoplasmic reticulum membrane|protein insertion into ER membrane" hsa04141 Protein processing in endoplasmic reticulum TRAM2 2018.683825 2248.12747 1789.24018 0.795880218 -0.329376777 0.30653524 1 15.72213828 13.0519455 9697 translocation associated membrane protein 2 "GO:0005515,GO:0006616,GO:0030176,GO:0032964,GO:0045048" "protein binding|SRP-dependent cotranslational protein targeting to membrane, translocation|integral component of endoplasmic reticulum membrane|collagen biosynthetic process|protein insertion into ER membrane" TRANK1 781.0981845 827.1891142 735.0072547 0.888560115 -0.17045871 0.645935702 1 3.522594004 3.264865814 9881 tetratricopeptide repeat and ankyrin repeat containing 1 TRAP1 1443.134513 1766.023385 1120.245642 0.634332281 -0.656689333 0.049212237 1 39.1092498 25.87689883 10131 TNF receptor associated protein 1 "GO:0003723,GO:0005164,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0006457,GO:0009386,GO:0016020,GO:0019901,GO:0051082,GO:0061077,GO:1901856,GO:1903427,GO:1903751" RNA binding|tumor necrosis factor receptor binding|protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|protein folding|translational attenuation|membrane|protein kinase binding|unfolded protein binding|chaperone-mediated protein folding|negative regulation of cellular respiration|negative regulation of reactive oxygen species biosynthetic process|negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide "hsa05012,hsa05022" Parkinson disease|Pathways of neurodegeneration - multiple diseases TRAPPC1 2229.454944 2074.569999 2384.339888 1.149317636 0.20077757 0.53101053 1 120.9086902 144.9484306 58485 trafficking protein particle complex subunit 1 "GO:0000139,GO:0005515,GO:0005576,GO:0005783,GO:0005829,GO:0006888,GO:0030008,GO:0035578,GO:0043312,GO:0048208" Golgi membrane|protein binding|extracellular region|endoplasmic reticulum|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|TRAPP complex|azurophil granule lumen|neutrophil degranulation|COPII vesicle coating TRAPPC10 1608.692832 1532.583512 1684.802152 1.099321596 0.136613494 0.678738808 1 9.161939125 10.5057749 7109 trafficking protein particle complex subunit 10 "GO:0000139,GO:0005515,GO:0005829,GO:0006891,GO:0030008,GO:0034498,GO:0048208,GO:1990071" Golgi membrane|protein binding|cytosol|intra-Golgi vesicle-mediated transport|TRAPP complex|early endosome to Golgi transport|COPII vesicle coating|TRAPPII protein complex TRAPPC11 804.7620979 794.7105232 814.8136725 1.025296191 0.036040741 0.925196743 1 7.06499639 7.555743705 60684 trafficking protein particle complex subunit 11 "GO:0005515,GO:0005794,GO:0005829,GO:0006888,GO:0007030,GO:0030008,GO:0045054,GO:0061635" protein binding|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|TRAPP complex|constitutive secretory pathway|regulation of protein complex stability TRAPPC12 677.7211335 630.2876564 725.1546106 1.150513743 0.202278217 0.596466653 1 3.387652157 4.065430594 51112 trafficking protein particle complex subunit 12 "GO:0000776,GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005793,GO:0005794,GO:0005829,GO:0006508,GO:0006888,GO:0007030,GO:0030008,GO:0048471,GO:0051310,GO:0090234,GO:1905342" kinetochore|endopeptidase activity|protein binding|nucleus|nucleoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|proteolysis|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|TRAPP complex|perinuclear region of cytoplasm|metaphase plate congression|regulation of kinetochore assembly|positive regulation of protein localization to kinetochore TRAPPC13 315.9605919 315.6513062 316.2698777 1.001959667 0.002824436 1 1 5.488027843 5.735647803 80006 trafficking protein particle complex subunit 13 "GO:0005515,GO:0005829,GO:1990072" protein binding|cytosol|TRAPPIII protein complex TRAPPC14 549.7218746 501.3882484 598.0555008 1.192799199 0.254351193 0.525400423 1 9.938765553 12.36561482 55262 trafficking protein particle complex subunit 14 "GO:0005515,GO:0005886,GO:0030496,GO:0034451,GO:0042127,GO:0043014,GO:0043231,GO:0060271,GO:0072686,GO:1990071" protein binding|plasma membrane|midbody|centriolar satellite|regulation of cell population proliferation|alpha-tubulin binding|intracellular membrane-bounded organelle|cilium assembly|mitotic spindle|TRAPPII protein complex TRAPPC2 309.3067166 264.9035077 353.7099255 1.335240626 0.417099756 0.374133299 1 4.604127709 6.412432831 6399 trafficking protein particle complex subunit 2 "GO:0000139,GO:0001501,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005793,GO:0005829,GO:0006355,GO:0006888,GO:0008134,GO:0030008,GO:0043231,GO:0044325,GO:0048208,GO:0048471" "Golgi membrane|skeletal system development|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|regulation of transcription, DNA-templated|endoplasmic reticulum to Golgi vesicle-mediated transport|transcription factor binding|TRAPP complex|intracellular membrane-bounded organelle|ion channel binding|COPII vesicle coating|perinuclear region of cytoplasm" TRAPPC2B 53.3797062 45.67301858 61.08639383 1.337472226 0.419508933 0.624626108 1 3.109109229 4.337471976 10597 trafficking protein particle complex subunit 2B "GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005793,GO:0006888,GO:0030008,GO:0043231,GO:0048471" nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|endoplasmic reticulum to Golgi vesicle-mediated transport|TRAPP complex|intracellular membrane-bounded organelle|perinuclear region of cytoplasm TRAPPC2L 620.991479 658.7064235 583.2765346 0.88548785 -0.175455584 0.653132107 1 13.34446263 12.32536037 51693 trafficking protein particle complex subunit 2L "GO:0000139,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0006888,GO:0030008,GO:0043231,GO:0048208,GO:0048471" Golgi membrane|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|TRAPP complex|intracellular membrane-bounded organelle|COPII vesicle coating|perinuclear region of cytoplasm TRAPPC3 863.1990165 883.0116925 843.3863406 0.955124771 -0.066238886 0.857624389 1 26.33770739 26.23940644 27095 trafficking protein particle complex subunit 3 "GO:0000139,GO:0005515,GO:0005783,GO:0005794,GO:0005829,GO:0006888,GO:0006891,GO:0030008,GO:0033106,GO:0048208" Golgi membrane|protein binding|endoplasmic reticulum|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|TRAPP complex|cis-Golgi network membrane|COPII vesicle coating TRAPPC4 958.8884311 891.1313402 1026.645522 1.152069819 0.204228151 0.566104897 1 34.8245823 41.84857221 51399 trafficking protein particle complex subunit 4 "GO:0000139,GO:0005515,GO:0005783,GO:0005795,GO:0005829,GO:0006888,GO:0006914,GO:0008021,GO:0016358,GO:0030008,GO:0030425,GO:0045202,GO:0045211,GO:0048208" Golgi membrane|protein binding|endoplasmic reticulum|Golgi stack|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|autophagy|synaptic vesicle|dendrite development|TRAPP complex|dendrite|synapse|postsynaptic membrane|COPII vesicle coating TRAPPC5 577.5656158 653.6316436 501.499588 0.767251085 -0.382229313 0.332901291 1 6.01019188 4.809963476 126003 trafficking protein particle complex subunit 5 "GO:0000139,GO:0005515,GO:0005783,GO:0005829,GO:0006888,GO:0030008,GO:0048208,GO:1990070,GO:1990071,GO:1990072" Golgi membrane|protein binding|endoplasmic reticulum|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|TRAPP complex|COPII vesicle coating|TRAPPI protein complex|TRAPPII protein complex|TRAPPIII protein complex TRAPPC6A 77.00848482 78.15160956 75.86536007 0.970745971 -0.042834281 0.973175478 1 4.947629153 5.009780132 79090 trafficking protein particle complex subunit 6A "GO:0000139,GO:0005515,GO:0005783,GO:0005801,GO:0005802,GO:0005829,GO:0006888,GO:0030008,GO:0043087,GO:0048208,GO:1903232" Golgi membrane|protein binding|endoplasmic reticulum|cis-Golgi network|trans-Golgi network|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|TRAPP complex|regulation of GTPase activity|COPII vesicle coating|melanosome assembly TRAPPC6B 505.1650108 452.6703619 557.6596598 1.231933227 0.300924062 0.461388165 1 6.090902472 7.826809155 122553 trafficking protein particle complex subunit 6B "GO:0000139,GO:0005515,GO:0005783,GO:0005801,GO:0005802,GO:0005829,GO:0006888,GO:0007399,GO:0030008,GO:0043087,GO:0048208" Golgi membrane|protein binding|endoplasmic reticulum|cis-Golgi network|trans-Golgi network|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|nervous system development|TRAPP complex|regulation of GTPase activity|COPII vesicle coating TRAPPC8 1259.299314 1322.487627 1196.111002 0.904440221 -0.144902944 0.670755083 1 10.23835721 9.658864528 22878 trafficking protein particle complex subunit 8 "GO:0000407,GO:0005515,GO:0005829,GO:0006888,GO:0007030,GO:0030008,GO:0030242,GO:0031410,GO:0034497,GO:1990072" phagophore assembly site|protein binding|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|TRAPP complex|autophagy of peroxisome|cytoplasmic vesicle|protein localization to phagophore assembly site|TRAPPIII protein complex TRAPPC9 877.061504 955.0735662 799.0494418 0.836636538 -0.25732709 0.476453514 1 4.143845355 3.616232097 83696 trafficking protein particle complex subunit 9 "GO:0000139,GO:0005515,GO:0005783,GO:0005802,GO:0005829,GO:0021987,GO:0030008,GO:0030182,GO:0048208,GO:0051092" Golgi membrane|protein binding|endoplasmic reticulum|trans-Golgi network|cytosol|cerebral cortex development|TRAPP complex|neuron differentiation|COPII vesicle coating|positive regulation of NF-kappaB transcription factor activity TRDMT1 310.0880996 385.683268 234.4929311 0.607993529 -0.717872126 0.12549269 1 1.26553268 0.802579849 1787 tRNA aspartic acid methyltransferase 1 "GO:0001975,GO:0003723,GO:0005654,GO:0005737,GO:0006400,GO:0008175,GO:0016428,GO:0030488,GO:0036416" response to amphetamine|RNA binding|nucleoplasm|cytoplasm|tRNA modification|tRNA methyltransferase activity|tRNA (cytosine-5-)-methyltransferase activity|tRNA methylation|tRNA stabilization TRERF1 881.1794732 798.7703471 963.5885994 1.206339974 0.270636548 0.453470833 1 3.361996193 4.230413954 55809 transcriptional regulating factor 1 "GO:0000118,GO:0001650,GO:0003677,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0008134,GO:0016575,GO:0030374,GO:0033142,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0050847,GO:0071393" "histone deacetylase complex|fibrillar center|DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|transcription factor binding|histone deacetylation|nuclear receptor coactivator activity|progesterone receptor binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|progesterone receptor signaling pathway|cellular response to progesterone stimulus" TRIAP1 383.0394821 422.2216828 343.8572814 0.814399865 -0.296190773 0.501600562 1 18.57866093 15.78221775 51499 TP53 regulated inhibitor of apoptosis 1 "GO:0002039,GO:0005515,GO:0005654,GO:0005739,GO:0005758,GO:0006915,GO:0006977,GO:0015914,GO:0030330,GO:0032991,GO:0034644,GO:0042981,GO:0043066,GO:0043154,GO:0045944,GO:0090201,GO:0097035,GO:0120009,GO:1902166,GO:1990050,GO:2001140" "p53 binding|protein binding|nucleoplasm|mitochondrion|mitochondrial intermembrane space|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|phospholipid transport|DNA damage response, signal transduction by p53 class mediator|protein-containing complex|cellular response to UV|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of transcription by RNA polymerase II|negative regulation of release of cytochrome c from mitochondria|regulation of membrane lipid distribution|intermembrane lipid transfer|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|phosphatidic acid transfer activity|positive regulation of phospholipid transport" TRIB1 692.9709591 898.236032 487.7058862 0.542959611 -0.881083211 0.020477918 0.616714654 12.25551892 6.940889961 10221 tribbles pseudokinase 1 "GO:0004672,GO:0004860,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0006469,GO:0007254,GO:0008134,GO:0014912,GO:0031434,GO:0031625,GO:0031665,GO:0032436,GO:0032496,GO:0043405,GO:0043433,GO:0045645,GO:0045651,GO:0045659,GO:0048662,GO:0055106" protein kinase activity|protein kinase inhibitor activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|negative regulation of protein kinase activity|JNK cascade|transcription factor binding|negative regulation of smooth muscle cell migration|mitogen-activated protein kinase kinase binding|ubiquitin protein ligase binding|negative regulation of lipopolysaccharide-mediated signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|response to lipopolysaccharide|regulation of MAP kinase activity|negative regulation of DNA-binding transcription factor activity|positive regulation of eosinophil differentiation|positive regulation of macrophage differentiation|negative regulation of neutrophil differentiation|negative regulation of smooth muscle cell proliferation|ubiquitin-protein transferase regulator activity TRIB2 10.06048503 14.20938356 5.911586499 0.416033987 -1.265226703 0.381088004 1 0.165666471 0.071891801 28951 tribbles pseudokinase 2 "GO:0000166,GO:0004672,GO:0004860,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0006468,GO:0006469,GO:0008134,GO:0031434,GO:0031625,GO:0032436,GO:0032693,GO:0043405,GO:0045599,GO:0055106" nucleotide binding|protein kinase activity|protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|cytoskeleton|protein phosphorylation|negative regulation of protein kinase activity|transcription factor binding|mitogen-activated protein kinase kinase binding|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of interleukin-10 production|regulation of MAP kinase activity|negative regulation of fat cell differentiation|ubiquitin-protein transferase regulator activity TRIB3 1451.906384 1287.979124 1615.833643 1.25454956 0.327169464 0.325871925 1 21.12422244 27.64295611 57761 tribbles pseudokinase 3 "GO:0000122,GO:0003714,GO:0004860,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006468,GO:0006469,GO:0010506,GO:0010827,GO:0016301,GO:0019216,GO:0019901,GO:0031434,GO:0031625,GO:0032092,GO:0032436,GO:0032869,GO:0034976,GO:0043405,GO:0045599,GO:0045717,GO:0045892,GO:0051443,GO:0051898,GO:0055106,GO:0070059" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein kinase inhibitor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein phosphorylation|negative regulation of protein kinase activity|regulation of autophagy|regulation of glucose transmembrane transport|kinase activity|regulation of lipid metabolic process|protein kinase binding|mitogen-activated protein kinase kinase binding|ubiquitin protein ligase binding|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to insulin stimulus|response to endoplasmic reticulum stress|regulation of MAP kinase activity|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of transcription, DNA-templated|positive regulation of ubiquitin-protein transferase activity|negative regulation of protein kinase B signaling|ubiquitin-protein transferase regulator activity|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" hsa04931 Insulin resistance TRIM11 559.7944838 550.1061349 569.4828328 1.035223563 0.04994236 0.904409235 1 10.26563562 11.08500576 81559 tripartite motif containing 11 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008134,GO:0008270,GO:0010468,GO:0016567,GO:0019904,GO:0032897,GO:0045087,GO:0045892,GO:0046597,GO:0046598,GO:0050768,GO:0051607,GO:0061630,GO:1902187" "protein binding|nucleoplasm|cytoplasm|cytosol|transcription factor binding|zinc ion binding|regulation of gene expression|protein ubiquitination|protein domain specific binding|negative regulation of viral transcription|innate immune response|negative regulation of transcription, DNA-templated|negative regulation of viral entry into host cell|positive regulation of viral entry into host cell|negative regulation of neurogenesis|defense response to virus|ubiquitin protein ligase activity|negative regulation of viral release from host cell" TRIM13 322.7062635 338.9952934 306.4172335 0.903898194 -0.145767804 0.757278305 1 2.51227915 2.368663362 10206 tripartite motif containing 13 "GO:0003713,GO:0004842,GO:0005515,GO:0005737,GO:0005789,GO:0008270,GO:0009653,GO:0010332,GO:0010942,GO:0016021,GO:0016239,GO:0016567,GO:0030433,GO:0032897,GO:0043123,GO:0043161,GO:0044322,GO:0045087,GO:0045893,GO:0051092,GO:0051865,GO:0061630,GO:0097038,GO:1902187,GO:1904380" "transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|cytoplasm|endoplasmic reticulum membrane|zinc ion binding|anatomical structure morphogenesis|response to gamma radiation|positive regulation of cell death|integral component of membrane|positive regulation of macroautophagy|protein ubiquitination|ubiquitin-dependent ERAD pathway|negative regulation of viral transcription|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|endoplasmic reticulum quality control compartment|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|ubiquitin protein ligase activity|perinuclear endoplasmic reticulum|negative regulation of viral release from host cell|endoplasmic reticulum mannose trimming" TRIM14 924.3299477 886.0565604 962.603335 1.086390393 0.119542627 0.739975114 1 4.421680852 5.010594289 9830 tripartite motif containing 14 "GO:0000209,GO:0003713,GO:0005515,GO:0005654,GO:0005737,GO:0005741,GO:0005829,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032880,GO:0032897,GO:0042803,GO:0043123,GO:0045087,GO:0045335,GO:0045893,GO:0046596,GO:0051091,GO:0051092,GO:0061630" "protein polyubiquitination|transcription coactivator activity|protein binding|nucleoplasm|cytoplasm|mitochondrial outer membrane|cytosol|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|regulation of protein localization|negative regulation of viral transcription|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|phagocytic vesicle|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity" TRIM16 424.7444731 478.0442611 371.444685 0.777008983 -0.363996818 0.394129849 1 7.21002245 5.843574514 10626 tripartite motif containing 16 "GO:0003677,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0008270,GO:0016605,GO:0016740,GO:0019966,GO:0032089,GO:0032526,GO:0032731,GO:0043966,GO:0043967,GO:0045618,GO:0045893,GO:0046683,GO:0048386,GO:0060416" "DNA binding|protein binding|cytoplasm|cytosol|plasma membrane|zinc ion binding|PML body|transferase activity|interleukin-1 binding|NACHT domain binding|response to retinoic acid|positive regulation of interleukin-1 beta production|histone H3 acetylation|histone H4 acetylation|positive regulation of keratinocyte differentiation|positive regulation of transcription, DNA-templated|response to organophosphorus|positive regulation of retinoic acid receptor signaling pathway|response to growth hormone" TRIM16L 271.985435 273.0231555 270.9477146 0.992398297 -0.011008835 0.990550957 1 3.670735242 3.799749806 147166 tripartite motif containing 16 like "GO:0005829,GO:0005886" cytosol|plasma membrane TRIM2 510.3503921 571.4202102 449.2805739 0.786252509 -0.346935379 0.394070055 1 3.116564484 2.555960225 23321 tripartite motif containing 2 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0008270,GO:0043161,GO:0043523,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of neuron apoptotic process|ubiquitin protein ligase activity TRIM21 459.8158777 417.146903 502.4848524 1.204575292 0.268524572 0.521711738 1 10.91835609 13.71851602 6737 tripartite motif containing 21 "GO:0000209,GO:0000932,GO:0003677,GO:0003713,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005776,GO:0005829,GO:0006513,GO:0007049,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0019005,GO:0019901,GO:0031410,GO:0031648,GO:0032088,GO:0032092,GO:0032479,GO:0032880,GO:0032897,GO:0034341,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0045787,GO:0045824,GO:0045893,GO:0046596,GO:0046598,GO:0051091,GO:0051092,GO:0051865,GO:0060333,GO:0061630,GO:0070534,GO:0090086,GO:1902187,GO:1990904" "protein polyubiquitination|P-body|DNA binding|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|autophagosome|cytosol|protein monoubiquitination|cell cycle|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|SCF ubiquitin ligase complex|protein kinase binding|cytoplasmic vesicle|protein destabilization|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein binding|regulation of type I interferon production|regulation of protein localization|negative regulation of viral transcription|response to interferon-gamma|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of cell cycle|negative regulation of innate immune response|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity|protein K63-linked ubiquitination|negative regulation of protein deubiquitination|negative regulation of viral release from host cell|ribonucleoprotein complex" hsa05322 Systemic lupus erythematosus TRIM22 56.365191 47.70293051 65.02745149 1.363175193 0.446970986 0.593731602 1 0.836559953 1.189500625 10346 tripartite motif containing 22 "GO:0000209,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006355,GO:0006955,GO:0008270,GO:0009615,GO:0010468,GO:0010508,GO:0015030,GO:0016032,GO:0016567,GO:0016604,GO:0016607,GO:0019901,GO:0030674,GO:0032880,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0045892,GO:0045893,GO:0046596,GO:0051091,GO:0051092,GO:0051607,GO:0060333,GO:0061630" "protein polyubiquitination|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|regulation of transcription, DNA-templated|immune response|zinc ion binding|response to virus|regulation of gene expression|positive regulation of autophagy|Cajal body|viral process|protein ubiquitination|nuclear body|nuclear speck|protein kinase binding|protein-macromolecule adaptor activity|regulation of protein localization|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|defense response to virus|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity" TRIM23 415.0957104 357.2645009 472.9269199 1.323744505 0.404624696 0.346388712 1 4.683972719 6.46747051 373 tripartite motif containing 23 "GO:0000139,GO:0003924,GO:0004842,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005765,GO:0005886,GO:0006886,GO:0008047,GO:0008270,GO:0016032,GO:0016192,GO:0016567,GO:0019003,GO:0042802,GO:0045087,GO:0050790" Golgi membrane|GTPase activity|ubiquitin-protein transferase activity|protein binding|GTP binding|nucleus|cytoplasm|lysosomal membrane|plasma membrane|intracellular protein transport|enzyme activator activity|zinc ion binding|viral process|vesicle-mediated transport|protein ubiquitination|GDP binding|identical protein binding|innate immune response|regulation of catalytic activity TRIM24 661.5694288 805.8750389 517.2638187 0.641866038 -0.639655866 0.094756741 1 9.188367349 6.151749988 8805 tripartite motif containing 24 "GO:0000791,GO:0002039,GO:0003682,GO:0003713,GO:0004672,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005726,GO:0005829,GO:0006366,GO:0008270,GO:0008285,GO:0016567,GO:0016922,GO:0030163,GO:0031647,GO:0034056,GO:0035064,GO:0042981,GO:0045892,GO:0045893,GO:0046777,GO:0055074,GO:0061630,GO:0070562,GO:0070577,GO:0071391,GO:1901796" "euchromatin|p53 binding|chromatin binding|transcription coactivator activity|protein kinase activity|signaling receptor binding|protein binding|nucleus|nucleoplasm|perichromatin fibrils|cytosol|transcription by RNA polymerase II|zinc ion binding|negative regulation of cell population proliferation|protein ubiquitination|nuclear receptor binding|protein catabolic process|regulation of protein stability|estrogen response element binding|methylated histone binding|regulation of apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein autophosphorylation|calcium ion homeostasis|ubiquitin protein ligase activity|regulation of vitamin D receptor signaling pathway|lysine-acetylated histone binding|cellular response to estrogen stimulus|regulation of signal transduction by p53 class mediator" other TRIM25 2876.722947 3249.889011 2503.556882 0.770351503 -0.376411214 0.23715328 1 28.65020252 23.02144395 7706 tripartite motif containing 25 "GO:0003713,GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0006511,GO:0006513,GO:0010494,GO:0016032,GO:0016604,GO:0016874,GO:0019985,GO:0030433,GO:0032480,GO:0032880,GO:0033280,GO:0039529,GO:0039552,GO:0043123,GO:0043627,GO:0045087,GO:0045296,GO:0045893,GO:0046596,GO:0046597,GO:0046872,GO:0051091,GO:0051092,GO:0060333,GO:0061630,GO:1902186,GO:1902187,GO:1990830" "transcription coactivator activity|RNA binding|protein binding|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cytoplasmic stress granule|viral process|nuclear body|ligase activity|translesion synthesis|ubiquitin-dependent ERAD pathway|negative regulation of type I interferon production|regulation of protein localization|response to vitamin D|RIG-I signaling pathway|RIG-I binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to estrogen|innate immune response|cadherin binding|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|negative regulation of viral entry into host cell|metal ion binding|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity|regulation of viral release from host cell|negative regulation of viral release from host cell|cellular response to leukemia inhibitory factor" "hsa04064,hsa04622,hsa05164" NF-kappa B signaling pathway|RIG-I-like receptor signaling pathway|Influenza A TRIM26 518.9235779 517.6275439 520.2196119 1.005007593 0.007206401 0.991209148 1 7.447729834 7.807449556 7726 tripartite motif containing 26 "GO:0003677,GO:0005515,GO:0005575,GO:0005634,GO:0005737,GO:0005829,GO:0008270,GO:0010468,GO:0016567,GO:0045087,GO:0046597,GO:0046872,GO:0051091,GO:0060333,GO:0061630,GO:1902187" DNA binding|protein binding|cellular_component|nucleus|cytoplasm|cytosol|zinc ion binding|regulation of gene expression|protein ubiquitination|innate immune response|negative regulation of viral entry into host cell|metal ion binding|positive regulation of DNA-binding transcription factor activity|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity|negative regulation of viral release from host cell TRIM27 1307.628489 1427.028092 1188.228886 0.832659773 -0.264200968 0.434328271 1 24.39214937 21.18524955 5987 tripartite motif containing 27 "GO:0000122,GO:0000209,GO:0001650,GO:0002820,GO:0003676,GO:0003677,GO:0003713,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0006469,GO:0007283,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0016605,GO:0019901,GO:0030904,GO:0031965,GO:0032609,GO:0032703,GO:0032720,GO:0032880,GO:0032897,GO:0034314,GO:0042147,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0045814,GO:0045893,GO:0046596,GO:0046872,GO:0051091,GO:0051092,GO:0061630,GO:0070534,GO:0090281" "negative regulation of transcription by RNA polymerase II|protein polyubiquitination|fibrillar center|negative regulation of adaptive immune response|nucleic acid binding|DNA binding|transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endosome|early endosome|cytosol|negative regulation of protein kinase activity|spermatogenesis|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|PML body|protein kinase binding|retromer complex|nuclear membrane|interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of tumor necrosis factor production|regulation of protein localization|negative regulation of viral transcription|Arp2/3 complex-mediated actin nucleation|retrograde transport, endosome to Golgi|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|metal ion binding|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity|protein K63-linked ubiquitination|negative regulation of calcium ion import" TRIM28 5192.047074 5301.115023 5082.979125 0.95885094 -0.060621538 0.850982144 1 77.10590887 77.11781019 10155 tripartite motif containing 28 "GO:0000122,GO:0000785,GO:0000791,GO:0000792,GO:0001837,GO:0003677,GO:0003682,GO:0003713,GO:0003714,GO:0003723,GO:0004672,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006325,GO:0006367,GO:0007265,GO:0007566,GO:0008270,GO:0016032,GO:0016567,GO:0016925,GO:0019789,GO:0031625,GO:0032991,GO:0035851,GO:0042307,GO:0043045,GO:0043388,GO:0045087,GO:0045739,GO:0045869,GO:0045892,GO:0045893,GO:0046777,GO:0060028,GO:0060669,GO:0070087,GO:0090309,GO:0090575,GO:1901536,GO:1902187,GO:1990841,GO:2000653" "negative regulation of transcription by RNA polymerase II|chromatin|euchromatin|heterochromatin|epithelial to mesenchymal transition|DNA binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|RNA binding|protein kinase activity|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|DNA repair|chromatin organization|transcription initiation from RNA polymerase II promoter|Ras protein signal transduction|embryo implantation|zinc ion binding|viral process|protein ubiquitination|protein sumoylation|SUMO transferase activity|ubiquitin protein ligase binding|protein-containing complex|Krueppel-associated box domain binding|positive regulation of protein import into nucleus|DNA methylation involved in embryo development|positive regulation of DNA binding|innate immune response|positive regulation of DNA repair|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein autophosphorylation|convergent extension involved in axis elongation|embryonic placenta morphogenesis|chromo shadow domain binding|positive regulation of DNA methylation-dependent heterochromatin assembly|RNA polymerase II transcription regulator complex|negative regulation of DNA demethylation|negative regulation of viral release from host cell|promoter-specific chromatin binding|regulation of genetic imprinting" other TRIM3 336.56207 309.5615704 363.5625697 1.174443486 0.231977292 0.614216868 1 4.637149208 5.680664273 10612 tripartite motif containing 3 "GO:0000209,GO:0005515,GO:0005737,GO:0005769,GO:0005794,GO:0007399,GO:0008022,GO:0008270,GO:0015031,GO:0030425,GO:0042802,GO:0043161,GO:0061630" protein polyubiquitination|protein binding|cytoplasm|early endosome|Golgi apparatus|nervous system development|protein C-terminus binding|zinc ion binding|protein transport|dendrite|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity TRIM32 876.1410659 892.1462962 860.1358356 0.964119718 -0.052715793 0.886850752 1 11.66642463 11.73234093 22954 tripartite motif containing 32 "GO:0000209,GO:0001894,GO:0003713,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005863,GO:0006511,GO:0007014,GO:0008270,GO:0009411,GO:0016567,GO:0017022,GO:0030307,GO:0030335,GO:0030957,GO:0031369,GO:0032479,GO:0032897,GO:0034612,GO:0042802,GO:0043123,GO:0043130,GO:0043621,GO:0045087,GO:0045444,GO:0045666,GO:0045732,GO:0045787,GO:0045862,GO:0045893,GO:0046716,GO:0048147,GO:0050769,GO:0051091,GO:0051092,GO:0051155,GO:0061564,GO:0061630,GO:0070936,GO:1902187,GO:1902230,GO:1903265,GO:1903883,GO:1903886,GO:2000147" "protein polyubiquitination|tissue homeostasis|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|striated muscle myosin thick filament|ubiquitin-dependent protein catabolic process|actin ubiquitination|zinc ion binding|response to UV|protein ubiquitination|myosin binding|positive regulation of cell growth|positive regulation of cell migration|Tat protein binding|translation initiation factor binding|regulation of type I interferon production|negative regulation of viral transcription|response to tumor necrosis factor|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|protein self-association|innate immune response|fat cell differentiation|positive regulation of neuron differentiation|positive regulation of protein catabolic process|positive regulation of cell cycle|positive regulation of proteolysis|positive regulation of transcription, DNA-templated|muscle cell cellular homeostasis|negative regulation of fibroblast proliferation|positive regulation of neurogenesis|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of striated muscle cell differentiation|axon development|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of viral release from host cell|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of interleukin-17-mediated signaling pathway|positive regulation of chemokine (C-C motif) ligand 20 production|positive regulation of cell motility" hsa04120 Ubiquitin mediated proteolysis TRIM33 1403.350317 1403.684104 1403.016529 0.999524412 -0.000686291 1 1 8.410226899 8.768333269 51592 tripartite motif containing 33 "GO:0000122,GO:0003677,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0008270,GO:0016567,GO:0017015,GO:0030514,GO:0045892,GO:0070410,GO:0070412" "negative regulation of transcription by RNA polymerase II|DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|zinc ion binding|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-templated|co-SMAD binding|R-SMAD binding" TRIM35 413.7635499 400.9076075 426.6194924 1.06413419 0.08968009 0.839498113 1 4.768566464 5.292978954 23087 tripartite motif containing 35 "GO:0003674,GO:0005634,GO:0005737,GO:0006915,GO:0008270,GO:0016567,GO:0043065,GO:0045087,GO:0045930,GO:0061630,GO:1902187" molecular_function|nucleus|cytoplasm|apoptotic process|zinc ion binding|protein ubiquitination|positive regulation of apoptotic process|innate immune response|negative regulation of mitotic cell cycle|ubiquitin protein ligase activity|negative regulation of viral release from host cell TRIM36 364.6569517 310.5765263 418.737377 1.348258292 0.431096907 0.333779159 1 3.093334397 4.350266878 55521 tripartite motif containing 36 "GO:0000209,GO:0000281,GO:0001669,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0007051,GO:0007340,GO:0008270,GO:0043014,GO:0051726,GO:0070507" protein polyubiquitination|mitotic cytokinesis|acrosomal vesicle|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|cytoskeleton|spindle organization|acrosome reaction|zinc ion binding|alpha-tubulin binding|regulation of cell cycle|regulation of microtubule cytoskeleton organization TRIM37 1618.622427 1504.164745 1733.080109 1.152187694 0.204375754 0.534428227 1 9.468137953 11.37899061 4591 tripartite motif containing 37 "GO:0000122,GO:0003682,GO:0003713,GO:0004842,GO:0005164,GO:0005515,GO:0005737,GO:0005777,GO:0005829,GO:0008270,GO:0016235,GO:0031625,GO:0032088,GO:0035098,GO:0035518,GO:0036353,GO:0042803,GO:0045893,GO:0046600,GO:0048471,GO:0051091,GO:0051092,GO:0051865,GO:0061630,GO:0070842" "negative regulation of transcription by RNA polymerase II|chromatin binding|transcription coactivator activity|ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|protein binding|cytoplasm|peroxisome|cytosol|zinc ion binding|aggresome|ubiquitin protein ligase binding|negative regulation of NF-kappaB transcription factor activity|ESC/E(Z) complex|histone H2A monoubiquitination|histone H2A-K119 monoubiquitination|protein homodimerization activity|positive regulation of transcription, DNA-templated|negative regulation of centriole replication|perinuclear region of cytoplasm|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|ubiquitin protein ligase activity|aggresome assembly" hsa04120 Ubiquitin mediated proteolysis TRIM38 676.8924916 539.9565752 813.8284081 1.507210849 0.591881255 0.120140612 1 3.74769024 5.891876418 10475 tripartite motif containing 38 "GO:0000209,GO:0003713,GO:0005515,GO:0005575,GO:0005654,GO:0005737,GO:0005829,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032880,GO:0042803,GO:0043123,GO:0045087,GO:0045893,GO:0046596,GO:0046598,GO:0051091,GO:0051092,GO:0060333,GO:0061630" "protein polyubiquitination|transcription coactivator activity|protein binding|cellular_component|nucleoplasm|cytoplasm|cytosol|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|regulation of protein localization|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity" TRIM39 214.5755965 221.2604011 207.8907919 0.939575228 -0.089919417 0.872672232 1 2.751979066 2.697072456 56658 tripartite motif containing 39 "GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0007095,GO:0008270,GO:0010468,GO:0016567,GO:0032435,GO:0042802,GO:0043124,GO:0045087,GO:0050821,GO:0061630,GO:1902806,GO:2000059,GO:2001235" protein binding|nucleus|cytoplasm|mitochondrion|cytosol|apoptotic process|mitotic G2 DNA damage checkpoint|zinc ion binding|regulation of gene expression|protein ubiquitination|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|protein stabilization|ubiquitin protein ligase activity|regulation of cell cycle G1/S phase transition|negative regulation of ubiquitin-dependent protein catabolic process|positive regulation of apoptotic signaling pathway TRIM4 728.7091859 714.5290017 742.8893701 1.039690997 0.056154813 0.884247476 1 10.66874211 11.5700019 89122 tripartite motif containing 4 "GO:0005737,GO:0005829,GO:0005886,GO:0008270,GO:0010468,GO:0016567,GO:0042802,GO:0045087,GO:0061630" cytoplasm|cytosol|plasma membrane|zinc ion binding|regulation of gene expression|protein ubiquitination|identical protein binding|innate immune response|ubiquitin protein ligase activity TRIM41 816.7661418 773.3964479 860.1358356 1.112153848 0.153356375 0.676920168 1 14.39536998 16.69950622 90933 tripartite motif containing 41 "GO:0005515,GO:0005730,GO:0005737,GO:0008270,GO:0016567,GO:0016604,GO:0042802,GO:0051091,GO:0061630,GO:0071222,GO:0071225" protein binding|nucleolus|cytoplasm|zinc ion binding|protein ubiquitination|nuclear body|identical protein binding|positive regulation of DNA-binding transcription factor activity|ubiquitin protein ligase activity|cellular response to lipopolysaccharide|cellular response to muramyl dipeptide TRIM44 3201.004592 3124.034471 3277.974714 1.049276103 0.069394353 0.828031814 1 12.09920662 13.24227507 54765 tripartite motif containing 44 "GO:0001961,GO:0002230,GO:0005515,GO:0005737,GO:0008270,GO:0010468,GO:0016567,GO:0045893,GO:0050821,GO:0061630,GO:0061944,GO:1901224" "positive regulation of cytokine-mediated signaling pathway|positive regulation of defense response to virus by host|protein binding|cytoplasm|zinc ion binding|regulation of gene expression|protein ubiquitination|positive regulation of transcription, DNA-templated|protein stabilization|ubiquitin protein ligase activity|negative regulation of protein K48-linked ubiquitination|positive regulation of NIK/NF-kappaB signaling" TRIM45 184.0378428 154.2733072 213.8023784 1.385867603 0.470789438 0.396934829 1 1.12828863 1.631014733 80263 tripartite motif containing 45 "GO:0000785,GO:0004842,GO:0005654,GO:0005829,GO:0008270,GO:0016567,GO:0045171,GO:0045893,GO:0060348" "chromatin|ubiquitin-protein transferase activity|nucleoplasm|cytosol|zinc ion binding|protein ubiquitination|intercellular bridge|positive regulation of transcription, DNA-templated|bone development" TRIM46 61.54389128 64.95718198 58.13060058 0.894906442 -0.160191232 0.858527221 1 0.794842259 0.741949785 80128 tripartite motif containing 46 "GO:0001578,GO:0001764,GO:0005856,GO:0007409,GO:0008270,GO:0030517,GO:0043194,GO:0044304,GO:0048490,GO:0099612,GO:1901953,GO:1903827,GO:1904115,GO:1990769" microtubule bundle formation|neuron migration|cytoskeleton|axonogenesis|zinc ion binding|negative regulation of axon extension|axon initial segment|main axon|anterograde synaptic vesicle transport|protein localization to axon|positive regulation of anterograde dense core granule transport|regulation of cellular protein localization|axon cytoplasm|proximal neuron projection TRIM47 331.4966928 367.4140606 295.579325 0.804485611 -0.313861478 0.495355679 1 7.692528321 6.455105048 91107 tripartite motif containing 47 "GO:0004842,GO:0005634,GO:0005829,GO:0008270,GO:0016567" ubiquitin-protein transferase activity|nucleus|cytosol|zinc ion binding|protein ubiquitination TRIM5 578.9626026 547.061267 610.8639383 1.116628018 0.159148661 0.688997491 1 6.243065177 7.271471721 85363 tripartite motif containing 5 "GO:0000209,GO:0000932,GO:0002218,GO:0003713,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006914,GO:0008270,GO:0010468,GO:0010508,GO:0016032,GO:0016567,GO:0019901,GO:0030674,GO:0031664,GO:0032880,GO:0038187,GO:0042802,GO:0042803,GO:0043123,GO:0043410,GO:0045087,GO:0045893,GO:0046596,GO:0046597,GO:0051091,GO:0051092,GO:0051607,GO:0060333,GO:0061630,GO:0070534,GO:1902187,GO:1990462" "protein polyubiquitination|P-body|activation of innate immune response|transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|autophagy|zinc ion binding|regulation of gene expression|positive regulation of autophagy|viral process|protein ubiquitination|protein kinase binding|protein-macromolecule adaptor activity|regulation of lipopolysaccharide-mediated signaling pathway|regulation of protein localization|pattern recognition receptor activity|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|innate immune response|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|negative regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|defense response to virus|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity|protein K63-linked ubiquitination|negative regulation of viral release from host cell|omegasome" hsa05170 Human immunodeficiency virus 1 infection TRIM50 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.068084688 0.022979984 135892 tripartite motif containing 50 "GO:0005515,GO:0005737,GO:0005829,GO:0008270,GO:0016567,GO:0042802,GO:0061630" protein binding|cytoplasm|cytosol|zinc ion binding|protein ubiquitination|identical protein binding|ubiquitin protein ligase activity TRIM52 277.5825386 285.2026271 269.9624501 0.946563687 -0.079228519 0.877099938 1 1.848305429 1.824901837 84851 tripartite motif containing 52 "GO:0003713,GO:0005634,GO:0005737,GO:0005829,GO:0008270,GO:0016567,GO:0016604,GO:0043123,GO:0045893,GO:0051091,GO:0051092,GO:0051607,GO:0051865,GO:0061630" "transcription coactivator activity|nucleus|cytoplasm|cytosol|zinc ion binding|protein ubiquitination|nuclear body|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|defense response to virus|protein autoubiquitination|ubiquitin protein ligase activity" TRIM55 15.64274285 25.37389921 5.911586499 0.232979033 -2.10172797 0.091438017 1 0.303303866 0.073707336 84675 tripartite motif containing 55 "GO:0002523,GO:0005515,GO:0005634,GO:0005737,GO:0005874,GO:0007165,GO:0008270,GO:0016567,GO:0042802,GO:0050904,GO:0061630,GO:1905517" leukocyte migration involved in inflammatory response|protein binding|nucleus|cytoplasm|microtubule|signal transduction|zinc ion binding|protein ubiquitination|identical protein binding|diapedesis|ubiquitin protein ligase activity|macrophage migration TRIM56 2433.561054 2354.697847 2512.424262 1.066983718 0.09353816 0.770382492 1 10.87418064 12.1023655 81844 tripartite motif containing 56 "GO:0000785,GO:0003723,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008270,GO:0032479,GO:0032608,GO:0034340,GO:0045087,GO:0045893,GO:0051607,GO:0070534" "chromatin|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|zinc ion binding|regulation of type I interferon production|interferon-beta production|response to type I interferon|innate immune response|positive regulation of transcription, DNA-templated|defense response to virus|protein K63-linked ubiquitination" TRIM59 224.3715792 183.7070303 265.0361281 1.442710862 0.528782194 0.309286769 1 2.433083945 3.661443394 286827 tripartite motif containing 59 "GO:0005515,GO:0005783,GO:0005789,GO:0008270,GO:0016021,GO:0016567,GO:0030992,GO:0043124,GO:0045087,GO:0061630" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|integral component of membrane|protein ubiquitination|intraciliary transport particle B|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|ubiquitin protein ligase activity TRIM6 36.03365848 38.5683268 33.49899016 0.868562184 -0.203298953 0.854333889 1 0.559218349 0.506638582 117854 tripartite motif containing 6 "GO:0000209,GO:0002230,GO:0002720,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008134,GO:0008270,GO:0010468,GO:0010508,GO:0010629,GO:0010800,GO:0010994,GO:0016032,GO:0016567,GO:0019901,GO:0030674,GO:0032496,GO:0032880,GO:0033138,GO:0035458,GO:0042802,GO:0042803,GO:0043123,GO:0045071,GO:0045087,GO:0045892,GO:0046596,GO:0051092,GO:0060340,GO:0061630,GO:0098586,GO:1901222,GO:1990782,GO:2000679,GO:2000737" "protein polyubiquitination|positive regulation of defense response to virus by host|positive regulation of cytokine production involved in immune response|protein binding|nucleoplasm|cytoplasm|cytosol|transcription factor binding|zinc ion binding|regulation of gene expression|positive regulation of autophagy|negative regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|free ubiquitin chain polymerization|viral process|protein ubiquitination|protein kinase binding|protein-macromolecule adaptor activity|response to lipopolysaccharide|regulation of protein localization|positive regulation of peptidyl-serine phosphorylation|cellular response to interferon-beta|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|innate immune response|negative regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of NF-kappaB transcription factor activity|positive regulation of type I interferon-mediated signaling pathway|ubiquitin protein ligase activity|cellular response to virus|regulation of NIK/NF-kappaB signaling|protein tyrosine kinase binding|positive regulation of transcription regulatory region DNA binding|negative regulation of stem cell differentiation" TRIM62 228.8861789 290.277407 167.4949508 0.577016836 -0.793314682 0.124692556 1 2.060769081 1.240319993 55223 tripartite motif containing 62 "GO:0003713,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0008270,GO:0010719,GO:0016567,GO:0032897,GO:0042802,GO:0043123,GO:0045087,GO:0045893,GO:0046596,GO:0051091,GO:0051092,GO:0060333,GO:0061630,GO:1902186" "transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|zinc ion binding|negative regulation of epithelial to mesenchymal transition|protein ubiquitination|negative regulation of viral transcription|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity|regulation of viral release from host cell" TRIM65 642.9669333 645.5119959 640.4218708 0.992114593 -0.011421329 0.980839788 1 8.251616699 8.539192683 201292 tripartite motif containing 65 "GO:0005654,GO:0005829,GO:0008270,GO:0010508" nucleoplasm|cytosol|zinc ion binding|positive regulation of autophagy TRIM66 623.6597593 706.409354 540.9101647 0.765717727 -0.385115438 0.320570545 1 2.330302984 1.86121705 9866 tripartite motif containing 66 "GO:0005654,GO:0008270,GO:0016235" nucleoplasm|zinc ion binding|aggresome TRIM68 266.6285854 243.5894324 289.6677385 1.189163814 0.249947468 0.614264966 1 3.711475758 4.603670617 55128 tripartite motif containing 68 "GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032880,GO:0035035,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0046596,GO:0048471,GO:0050681,GO:0051092,GO:0051865,GO:0060333,GO:0060765,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|regulation of protein localization|histone acetyltransferase binding|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of viral entry into host cell|perinuclear region of cytoplasm|androgen receptor binding|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|interferon-gamma-mediated signaling pathway|regulation of androgen receptor signaling pathway|ubiquitin protein ligase activity TRIM7 342.8002636 331.8906017 353.7099255 1.065742518 0.091858927 0.845223653 1 3.029210332 3.367422828 81786 tripartite motif containing 7 "GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0008270,GO:0016567,GO:0061630" protein binding|nucleus|cytoplasm|Golgi apparatus|zinc ion binding|protein ubiquitination|ubiquitin protein ligase activity TRIM71 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.01771735 0.017939912 131405 tripartite motif containing 71 "GO:0000082,GO:0000209,GO:0000932,GO:0001843,GO:0004842,GO:0005515,GO:0008270,GO:0008543,GO:0010586,GO:0010608,GO:0017148,GO:0021915,GO:0030371,GO:0035196,GO:0035198,GO:0035278,GO:0043161,GO:0051865,GO:0060964,GO:0061158,GO:0061630,GO:0072089,GO:2000177,GO:2000637" G1/S transition of mitotic cell cycle|protein polyubiquitination|P-body|neural tube closure|ubiquitin-protein transferase activity|protein binding|zinc ion binding|fibroblast growth factor receptor signaling pathway|miRNA metabolic process|posttranscriptional regulation of gene expression|negative regulation of translation|neural tube development|translation repressor activity|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|proteasome-mediated ubiquitin-dependent protein catabolic process|protein autoubiquitination|regulation of gene silencing by miRNA|3'-UTR-mediated mRNA destabilization|ubiquitin protein ligase activity|stem cell proliferation|regulation of neural precursor cell proliferation|positive regulation of gene silencing by miRNA hsa05206 MicroRNAs in cancer TRIM73 2.507698369 3.044867905 1.970528833 0.64716398 -0.627796782 0.981537091 1 0.114230976 0.077110613 375593 tripartite motif containing 73 "GO:0005737,GO:0005829,GO:0008270,GO:0016567,GO:0061630" cytoplasm|cytosol|zinc ion binding|protein ubiquitination|ubiquitin protein ligase activity TRIM74 99.57777014 105.5554207 93.60011957 0.886739108 -0.173418391 0.810334284 1 1.718974174 1.589941496 378108 tripartite motif containing 74 "GO:0005737,GO:0005829,GO:0008270,GO:0016567,GO:0061630" cytoplasm|cytosol|zinc ion binding|protein ubiquitination|ubiquitin protein ligase activity TRIM8 7311.410716 6585.034323 8037.78711 1.220614308 0.287607406 0.381435641 1 120.8365065 153.8482451 81603 tripartite motif containing 8 "GO:0003713,GO:0005515,GO:0005829,GO:0008270,GO:0010508,GO:0016567,GO:0016605,GO:0016740,GO:0019827,GO:0032897,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0045893,GO:0046597,GO:0051091,GO:0051092,GO:0060333,GO:1900182,GO:1902187" "transcription coactivator activity|protein binding|cytosol|zinc ion binding|positive regulation of autophagy|protein ubiquitination|PML body|transferase activity|stem cell population maintenance|negative regulation of viral transcription|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription, DNA-templated|negative regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway|positive regulation of protein localization to nucleus|negative regulation of viral release from host cell" TRIM9 72.91624779 101.4955968 44.33689874 0.436835687 -1.194837375 0.114134107 1 0.591665967 0.269594253 114088 tripartite motif containing 9 "GO:0000149,GO:0005515,GO:0005737,GO:0005856,GO:0008021,GO:0008270,GO:0016079,GO:0016567,GO:0019904,GO:0030425,GO:0035544,GO:0042803,GO:0043161,GO:0045955,GO:0061630,GO:0099523" SNARE binding|protein binding|cytoplasm|cytoskeleton|synaptic vesicle|zinc ion binding|synaptic vesicle exocytosis|protein ubiquitination|protein domain specific binding|dendrite|negative regulation of SNARE complex assembly|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of calcium ion-dependent exocytosis|ubiquitin protein ligase activity|presynaptic cytosol TRIML2 1634.43936 1406.728972 1862.149747 1.323744505 0.404624696 0.217825684 1 31.27561888 43.18431273 205860 tripartite motif family like 2 "GO:0000209,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032526,GO:0032880,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0046596,GO:0051092,GO:0061630" protein polyubiquitination|protein binding|nucleoplasm|cytoplasm|cytosol|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|response to retinoic acid|regulation of protein localization|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of viral entry into host cell|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity TRIO 8002.931741 8057.735433 7948.128048 0.986397247 -0.019759322 0.95271978 1 20.31439463 20.90122142 7204 trio Rho guanine nucleotide exchange factor "GO:0004674,GO:0005085,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007185,GO:0007186,GO:0007411,GO:0007417,GO:0042995,GO:0043065,GO:0045599,GO:0048812,GO:0050790,GO:0051056,GO:0106310,GO:0106311" protein serine/threonine kinase activity|guanyl-nucleotide exchange factor activity|protein binding|ATP binding|cytosol|protein phosphorylation|transmembrane receptor protein tyrosine phosphatase signaling pathway|G protein-coupled receptor signaling pathway|axon guidance|central nervous system development|cell projection|positive regulation of apoptotic process|negative regulation of fat cell differentiation|neuron projection morphogenesis|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|protein serine kinase activity|protein threonine kinase activity TRIOBP 2150.038722 1865.48907 2434.588373 1.30506708 0.384123963 0.231354886 1 8.740096239 11.89775384 11078 TRIO and F-actin binding protein "GO:0005634,GO:0005737,GO:0005815,GO:0005925,GO:0007015,GO:0007049,GO:0007605,GO:0015629,GO:0030047,GO:0030496,GO:0031267,GO:0031625,GO:0045159,GO:0051015,GO:0051016,GO:0051301,GO:0060088,GO:0120044,GO:1900026" nucleus|cytoplasm|microtubule organizing center|focal adhesion|actin filament organization|cell cycle|sensory perception of sound|actin cytoskeleton|actin modification|midbody|small GTPase binding|ubiquitin protein ligase binding|myosin II binding|actin filament binding|barbed-end actin filament capping|cell division|auditory receptor cell stereocilium organization|stereocilium base|positive regulation of substrate adhesion-dependent cell spreading TRIP10 1405.037538 1215.91725 1594.157826 1.311074274 0.390749418 0.242672377 1 26.36212295 36.05152221 9322 thyroid hormone receptor interactor 10 "GO:0001891,GO:0005515,GO:0005654,GO:0005737,GO:0005764,GO:0005794,GO:0005829,GO:0005856,GO:0005938,GO:0006897,GO:0007154,GO:0007165,GO:0008289,GO:0030036,GO:0042802,GO:0042995,GO:0043231,GO:0048471,GO:0051056,GO:0061024,GO:0070062" phagocytic cup|protein binding|nucleoplasm|cytoplasm|lysosome|Golgi apparatus|cytosol|cytoskeleton|cell cortex|endocytosis|cell communication|signal transduction|lipid binding|actin cytoskeleton organization|identical protein binding|cell projection|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|membrane organization|extracellular exosome hsa04910 Insulin signaling pathway TRIP11 993.0000575 1067.733679 918.2664362 0.860014491 -0.217567126 0.538294488 1 5.392595143 4.837483703 9321 thyroid hormone receptor interactor 11 "GO:0000139,GO:0002079,GO:0002081,GO:0003281,GO:0003413,GO:0003713,GO:0005515,GO:0005654,GO:0005793,GO:0005794,GO:0005801,GO:0005856,GO:0005929,GO:0006366,GO:0006486,GO:0016607,GO:0030133,GO:0033116,GO:0035735,GO:0045893,GO:0051216,GO:0060122,GO:0090161,GO:0099041" "Golgi membrane|inner acrosomal membrane|outer acrosomal membrane|ventricular septum development|chondrocyte differentiation involved in endochondral bone morphogenesis|transcription coactivator activity|protein binding|nucleoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|cytoskeleton|cilium|transcription by RNA polymerase II|protein glycosylation|nuclear speck|transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|intraciliary transport involved in cilium assembly|positive regulation of transcription, DNA-templated|cartilage development|inner ear receptor cell stereocilium organization|Golgi ribbon formation|vesicle tethering to Golgi" TRIP12 5396.246465 5351.862821 5440.630108 1.016586241 0.02373261 0.941884104 1 17.166116 18.20254864 9320 thyroid hormone receptor interactor 12 "GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006511,GO:0006974,GO:0016607,GO:0045995,GO:0046966,GO:0061630,GO:1901315,GO:2000779,GO:2000780" protein polyubiquitination|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|nuclear speck|regulation of embryonic development|thyroid hormone receptor binding|ubiquitin protein ligase activity|negative regulation of histone H2A K63-linked ubiquitination|regulation of double-strand break repair|negative regulation of double-strand break repair hsa04120 Ubiquitin mediated proteolysis TRIP13 1648.571793 1463.566506 1833.577079 1.252814321 0.32517261 0.321502245 1 22.94165286 29.97970417 9319 thyroid hormone receptor interactor 13 "GO:0001556,GO:0001673,GO:0003712,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0006302,GO:0006355,GO:0006366,GO:0007094,GO:0007130,GO:0007131,GO:0007141,GO:0007144,GO:0007283,GO:0007286,GO:0016887,GO:0042802,GO:0048477,GO:0051598" "oocyte maturation|male germ cell nucleus|transcription coregulator activity|protein binding|ATP binding|nucleus|chromosome|double-strand break repair|regulation of transcription, DNA-templated|transcription by RNA polymerase II|mitotic spindle assembly checkpoint|synaptonemal complex assembly|reciprocal meiotic recombination|male meiosis I|female meiosis I|spermatogenesis|spermatid development|ATPase activity|identical protein binding|oogenesis|meiotic recombination checkpoint" TRIP4 421.7050484 404.9674314 438.4426654 1.082661546 0.114582308 0.79290818 1 10.1888583 11.50625949 9325 thyroid hormone receptor interactor 4 "GO:0002020,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006355,GO:0008270,GO:0016604,GO:0016922,GO:0019901,GO:0030331,GO:0030520,GO:0031594,GO:0032991,GO:0035035,GO:0044389,GO:0045661,GO:0045893,GO:0099053,GO:1901998" "protease binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|regulation of transcription, DNA-templated|zinc ion binding|nuclear body|nuclear receptor binding|protein kinase binding|estrogen receptor binding|intracellular estrogen receptor signaling pathway|neuromuscular junction|protein-containing complex|histone acetyltransferase binding|ubiquitin-like protein ligase binding|regulation of myoblast differentiation|positive regulation of transcription, DNA-templated|activating signal cointegrator 1 complex|toxin transport" TRIP6 1338.486169 1414.84862 1262.123718 0.892055659 -0.164794367 0.625337405 1 42.3255117 39.38311826 7205 thyroid hormone receptor interactor 6 "GO:0001725,GO:0003723,GO:0005149,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007165,GO:0019900,GO:0030335,GO:0043009,GO:0046872,GO:0046966,GO:0048041,GO:1901224" stress fiber|RNA binding|interleukin-1 receptor binding|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|signal transduction|kinase binding|positive regulation of cell migration|chordate embryonic development|metal ion binding|thyroid hormone receptor binding|focal adhesion assembly|positive regulation of NIK/NF-kappaB signaling hsa04621 NOD-like receptor signaling pathway TRIQK 896.4740823 699.3046622 1093.643502 1.563901346 0.645149507 0.073106523 1 8.175741953 13.33682519 286144 triple QxxK/R motif containing "GO:0005789,GO:0016021" endoplasmic reticulum membrane|integral component of membrane TRIR 1979.973968 1891.877925 2068.07001 1.09313079 0.128466025 0.691171767 1 109.0067608 124.2915178 79002 telomerase RNA component interacting RNase "GO:0003723,GO:0005515,GO:0008408,GO:0008409,GO:0016075,GO:0090503" "RNA binding|protein binding|3'-5' exonuclease activity|5'-3' exonuclease activity|rRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic" TRIT1 466.9920768 469.9246134 464.0595402 0.987519119 -0.018119415 0.970911506 1 4.342277663 4.472795403 54802 tRNA isopentenyltransferase 1 "GO:0003676,GO:0005524,GO:0005575,GO:0005739,GO:0005759,GO:0006400,GO:0008270,GO:0052381,GO:0070900" nucleic acid binding|ATP binding|cellular_component|mitochondrion|mitochondrial matrix|tRNA modification|zinc ion binding|tRNA dimethylallyltransferase activity|mitochondrial tRNA modification TRMO 197.3658824 189.7967661 204.9349986 1.079760224 0.110710977 0.846195817 1 2.288154401 2.57708404 51531 tRNA methyltransferase O "GO:0005515,GO:0016430,GO:0030488" protein binding|tRNA (adenine-N6-)-methyltransferase activity|tRNA methylation TRMT1 552.1526225 532.8518834 571.4533616 1.072443167 0.100901196 0.803839564 1 11.4887476 12.85176882 55621 tRNA methyltransferase 1 "GO:0000049,GO:0002940,GO:0003723,GO:0004809,GO:0005515,GO:0005634,GO:0005654,GO:0006400,GO:0046872" tRNA binding|tRNA N2-guanine methylation|RNA binding|tRNA (guanine-N2-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|tRNA modification|metal ion binding TRMT10A 97.74085329 114.6900244 80.79168216 0.704435129 -0.505461239 0.462786223 1 1.49245764 1.096627036 93587 tRNA methyltransferase 10A "GO:0000049,GO:0002939,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0005829,GO:0009019,GO:0015629,GO:0030488,GO:0052905,GO:0070062,GO:0090646" tRNA binding|tRNA N1-guanine methylation|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|mitochondrion|cytosol|tRNA (guanine-N1-)-methyltransferase activity|actin cytoskeleton|tRNA methylation|tRNA (guanine(9)-N(1))-methyltransferase activity|extracellular exosome|mitochondrial tRNA processing TRMT10B 269.2374826 287.232539 251.2424262 0.874700433 -0.193139087 0.697731722 1 1.79663021 1.639207638 158234 tRNA methyltransferase 10B "GO:0000049,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0009019,GO:0030488,GO:0052905,GO:0090646" tRNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|tRNA (guanine-N1-)-methyltransferase activity|tRNA methylation|tRNA (guanine(9)-N(1))-methyltransferase activity|mitochondrial tRNA processing TRMT10C 489.1996203 539.9565752 438.4426654 0.81199616 -0.300455191 0.46572392 1 15.0837814 12.77556555 54931 "tRNA methyltransferase 10C, mitochondrial RNase P subunit" "GO:0000049,GO:0000964,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0009019,GO:0016429,GO:0030678,GO:0042645,GO:0042802,GO:0052905,GO:0061953,GO:0070131,GO:0070901,GO:0080009,GO:0090646,GO:0097745,GO:1990180" tRNA binding|mitochondrial RNA 5'-end processing|RNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|tRNA (guanine-N1-)-methyltransferase activity|tRNA (adenine-N1-)-methyltransferase activity|mitochondrial ribonuclease P complex|mitochondrial nucleoid|identical protein binding|tRNA (guanine(9)-N(1))-methyltransferase activity|mRNA (adenine-N1-)-methyltransferase activity|positive regulation of mitochondrial translation|mitochondrial tRNA methylation|mRNA methylation|mitochondrial tRNA processing|mitochondrial tRNA 5'-end processing|mitochondrial tRNA 3'-end processing TRMT11 267.4357005 231.4099608 303.4614403 1.311358592 0.391062245 0.426791169 1 4.206783255 5.754234179 60487 tRNA methyltransferase 11 homolog "GO:0000049,GO:0004809,GO:0005515,GO:0005737,GO:0008168,GO:0030488" tRNA binding|tRNA (guanine-N2-)-methyltransferase activity|protein binding|cytoplasm|methyltransferase activity|tRNA methylation TRMT112 2103.790431 2240.007822 1967.57304 0.878377754 -0.187086578 0.560671036 1 114.8264109 105.2056462 51504 tRNA methyltransferase subunit 11-2 "GO:0005515,GO:0005654,GO:0005829,GO:0006415,GO:0008276,GO:0016435,GO:0018364,GO:0030488,GO:0031167,GO:0032259,GO:0032991,GO:0034968,GO:0046982,GO:0048471,GO:0070476,GO:2000234" protein binding|nucleoplasm|cytosol|translational termination|protein methyltransferase activity|rRNA (guanine) methyltransferase activity|peptidyl-glutamine methylation|tRNA methylation|rRNA methylation|methylation|protein-containing complex|histone lysine methylation|protein heterodimerization activity|perinuclear region of cytoplasm|rRNA (guanine-N7)-methylation|positive regulation of rRNA processing TRMT12 497.2653281 485.1489529 509.3817034 1.049949094 0.070319381 0.868055701 1 11.1332501 12.19287546 55039 tRNA methyltransferase 12 homolog "GO:0005515,GO:0005737,GO:0008175,GO:0030488,GO:0102522" protein binding|cytoplasm|tRNA methyltransferase activity|tRNA methylation|tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity TRMT13 376.8161343 400.9076075 352.7246611 0.879815335 -0.184727347 0.678849123 1 4.233643871 3.885275147 54482 tRNA methyltransferase 13 homolog "GO:0008175,GO:0030488,GO:0046872,GO:0106050" tRNA methyltransferase activity|tRNA methylation|metal ion binding|tRNA 2'-O-methyltransferase activity TRMT1L 580.2744741 569.3902983 591.1586499 1.038230985 0.054127449 0.894957202 1 5.117588273 5.542111486 81627 tRNA methyltransferase 1 like "GO:0000049,GO:0002940,GO:0003723,GO:0004809,GO:0005515,GO:0005634,GO:0007610,GO:0046872" tRNA binding|tRNA N2-guanine methylation|RNA binding|tRNA (guanine-N2-)-methyltransferase activity|protein binding|nucleus|behavior|metal ion binding TRMT2A 599.4965328 637.3923481 561.6007174 0.881091088 -0.182636921 0.642559083 1 10.67868801 9.814193951 27037 tRNA methyltransferase 2 homolog A "GO:0001510,GO:0003723,GO:0005515,GO:0006396,GO:0008173" RNA methylation|RNA binding|protein binding|RNA processing|RNA methyltransferase activity TRMT2B 668.9076936 701.3345741 636.4808131 0.907528071 -0.139985827 0.716072567 1 5.726281158 5.420616275 79979 tRNA methyltransferase 2 homolog B "GO:0005515,GO:0030488,GO:0030697" protein binding|tRNA methylation|S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity TRMT44 163.3175985 152.2433953 174.3918017 1.145480245 0.195952578 0.741036877 1 1.112478847 1.329215189 152992 tRNA methyltransferase 44 homolog "GO:0005737,GO:0016300,GO:0030488,GO:0046872" cytoplasm|tRNA (uracil) methyltransferase activity|tRNA methylation|metal ion binding TRMT5 467.7667787 489.2087768 446.3247807 0.912340093 -0.132356377 0.753752891 1 4.106181425 3.907606506 57570 tRNA methyltransferase 5 "GO:0002939,GO:0005634,GO:0005737,GO:0005759,GO:0008175,GO:0009019,GO:0030488,GO:0052906,GO:0070901" tRNA N1-guanine methylation|nucleus|cytoplasm|mitochondrial matrix|tRNA methyltransferase activity|tRNA (guanine-N1-)-methyltransferase activity|tRNA methylation|tRNA (guanine(37)-N(1))-methyltransferase activity|mitochondrial tRNA methylation TRMT6 723.3117584 817.0395545 629.5839622 0.770567298 -0.376007133 0.316327292 1 13.56726921 10.90483118 51605 tRNA methyltransferase 6 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006400,GO:0016429,GO:0030488,GO:0031515,GO:0080009" RNA binding|protein binding|nucleus|nucleoplasm|tRNA modification|tRNA (adenine-N1-)-methyltransferase activity|tRNA methylation|tRNA (m1A) methyltransferase complex|mRNA methylation TRMT61A 524.4558552 592.7342855 456.1774249 0.769615384 -0.377790457 0.349894811 1 9.331644551 7.491139041 115708 tRNA methyltransferase 61A "GO:0005515,GO:0005634,GO:0005654,GO:0006400,GO:0016429,GO:0030488,GO:0031515,GO:0061953,GO:0080009" protein binding|nucleus|nucleoplasm|tRNA modification|tRNA (adenine-N1-)-methyltransferase activity|tRNA methylation|tRNA (m1A) methyltransferase complex|mRNA (adenine-N1-)-methyltransferase activity|mRNA methylation TRMT61B 237.1624492 216.1856213 258.1392771 1.194063119 0.2558791 0.619769801 1 5.047966372 6.28723462 55006 tRNA methyltransferase 61B "GO:0005515,GO:0005739,GO:0005759,GO:0016429,GO:0016433,GO:0030488,GO:0031167,GO:0031515,GO:0051260,GO:0061953,GO:0070901,GO:0080009" protein binding|mitochondrion|mitochondrial matrix|tRNA (adenine-N1-)-methyltransferase activity|rRNA (adenine) methyltransferase activity|tRNA methylation|rRNA methylation|tRNA (m1A) methyltransferase complex|protein homooligomerization|mRNA (adenine-N1-)-methyltransferase activity|mitochondrial tRNA methylation|mRNA methylation TRMU 519.5295331 592.7342855 446.3247807 0.752993022 -0.4092916 0.312186306 1 16.13973146 12.67661164 55687 tRNA mitochondrial 2-thiouridylase "GO:0000049,GO:0002143,GO:0005524,GO:0005739,GO:0016783" tRNA binding|tRNA wobble position uridine thiolation|ATP binding|mitochondrion|sulfurtransferase activity TRNAU1AP 381.2377 366.3991046 396.0762955 1.080996898 0.112362383 0.803068307 1 10.31507619 11.6308865 54952 tRNA selenocysteine 1 associated protein 1 "GO:0000049,GO:0001514,GO:0003723,GO:0005515,GO:0005634,GO:0005737" tRNA binding|selenocysteine incorporation|RNA binding|protein binding|nucleus|cytoplasm TRNP1 156.5543596 161.377999 151.7307201 0.940219368 -0.088930696 0.889448581 1 4.070331843 3.991856679 388610 TMF1 regulated nuclear protein 1 "GO:0000791,GO:0003677,GO:0005634,GO:0007049,GO:0021696,GO:0042127,GO:0051726,GO:0061351" euchromatin|DNA binding|nucleus|cell cycle|cerebellar cortex morphogenesis|regulation of cell population proliferation|regulation of cell cycle|neural precursor cell proliferation TRNT1 667.937275 702.3495301 633.5250198 0.902008178 -0.148787582 0.698905379 1 6.991259033 6.577817171 51095 tRNA nucleotidyl transferase 1 "GO:0000049,GO:0001680,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0034062,GO:0042780,GO:0052927,GO:0052928,GO:0052929,GO:1990180" tRNA binding|tRNA 3'-terminal CCA addition|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|5'-3' RNA polymerase activity|tRNA 3'-end processing|CTP:tRNA cytidylyltransferase activity|CTP:3'-cytidine-tRNA cytidylyltransferase activity|ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity|mitochondrial tRNA 3'-end processing hsa03013 RNA transport TROAP 1156.57424 1001.761541 1311.386938 1.309080939 0.3885543 0.258856409 1 16.60742653 22.67695659 10024 trophinin associated protein "GO:0005515,GO:0005737,GO:0007155" protein binding|cytoplasm|cell adhesion TRPC1 649.9461779 550.1061349 749.786221 1.362984656 0.446769321 0.244722148 1 3.159552628 4.491924935 7220 transient receptor potential cation channel subfamily C member 1 "GO:0005102,GO:0005261,GO:0005262,GO:0005515,GO:0005886,GO:0005887,GO:0006816,GO:0006828,GO:0015279,GO:0034703,GO:0042438,GO:0043235,GO:0051117,GO:0051281,GO:0051480,GO:0051592,GO:0070588,GO:0070679,GO:1903779" "signaling receptor binding|cation channel activity|calcium channel activity|protein binding|plasma membrane|integral component of plasma membrane|calcium ion transport|manganese ion transport|store-operated calcium channel activity|cation channel complex|melanin biosynthetic process|receptor complex|ATPase binding|positive regulation of release of sequestered calcium ion into cytosol|regulation of cytosolic calcium ion concentration|response to calcium ion|calcium ion transmembrane transport|inositol 1,4,5 trisphosphate binding|regulation of cardiac conduction" "hsa04360,hsa04724,hsa04726,hsa04929,hsa04972" Axon guidance|Glutamatergic synapse|Serotonergic synapse|GnRH secretion|Pancreatic secretion TRPC3 35.40741429 29.43372308 41.38110549 1.405907957 0.491502146 0.615508992 1 0.17496646 0.256582849 7222 transient receptor potential cation channel subfamily C member 3 "GO:0005262,GO:0005515,GO:0005886,GO:0005887,GO:0006816,GO:0006828,GO:0007338,GO:0007602,GO:0010524,GO:0015279,GO:0030168,GO:0033198,GO:0034703,GO:0051480,GO:0051592,GO:0070588,GO:0070679,GO:1903244" "calcium channel activity|protein binding|plasma membrane|integral component of plasma membrane|calcium ion transport|manganese ion transport|single fertilization|phototransduction|positive regulation of calcium ion transport into cytosol|store-operated calcium channel activity|platelet activation|response to ATP|cation channel complex|regulation of cytosolic calcium ion concentration|response to calcium ion|calcium ion transmembrane transport|inositol 1,4,5 trisphosphate binding|positive regulation of cardiac muscle hypertrophy in response to stress" "hsa04360,hsa05017,hsa05022" Axon guidance|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases TRPC4AP 4784.940121 4917.461667 4652.418575 0.946101646 -0.079932905 0.803469903 1 71.19842357 70.26258205 26133 transient receptor potential cation channel subfamily C member 4 associated protein "GO:0005515,GO:0005886,GO:0006511,GO:0016567,GO:0019902,GO:0031464,GO:0048820,GO:0070588" protein binding|plasma membrane|ubiquitin-dependent protein catabolic process|protein ubiquitination|phosphatase binding|Cul4A-RING E3 ubiquitin ligase complex|hair follicle maturation|calcium ion transmembrane transport TRPM2 721.3845291 651.6017317 791.1673265 1.214188496 0.279992409 0.456369244 1 5.26588942 6.669200568 7226 transient receptor potential cation channel subfamily M member 2 "GO:0001659,GO:0002407,GO:0005261,GO:0005262,GO:0005272,GO:0005509,GO:0005764,GO:0005765,GO:0005886,GO:0005887,GO:0006816,GO:0014074,GO:0015278,GO:0016787,GO:0030659,GO:0035579,GO:0035584,GO:0035725,GO:0042995,GO:0043204,GO:0043312,GO:0047631,GO:0051209,GO:0051289,GO:0051489,GO:0070301,GO:0070588,GO:0070821,GO:0070838,GO:0071277,GO:0071415,GO:0071502,GO:0071577,GO:0072571,GO:0097028,GO:0097553,GO:0098655,GO:0098703,GO:0099604,GO:0101003,GO:2000249" temperature homeostasis|dendritic cell chemotaxis|cation channel activity|calcium channel activity|sodium channel activity|calcium ion binding|lysosome|lysosomal membrane|plasma membrane|integral component of plasma membrane|calcium ion transport|response to purine-containing compound|calcium-release channel activity|hydrolase activity|cytoplasmic vesicle membrane|specific granule membrane|calcium-mediated signaling using intracellular calcium source|sodium ion transmembrane transport|cell projection|perikaryon|neutrophil degranulation|ADP-ribose diphosphatase activity|release of sequestered calcium ion into cytosol|protein homotetramerization|regulation of filopodium assembly|cellular response to hydrogen peroxide|calcium ion transmembrane transport|tertiary granule membrane|divalent metal ion transport|cellular response to calcium ion|cellular response to purine-containing compound|cellular response to temperature stimulus|zinc ion transmembrane transport|mono-ADP-D-ribose binding|dendritic cell differentiation|calcium ion transmembrane import into cytosol|cation transmembrane transport|calcium ion import across plasma membrane|ligand-gated calcium channel activity|ficolin-1-rich granule membrane|regulation of actin cytoskeleton reorganization "hsa04621,hsa04921" NOD-like receptor signaling pathway|Oxytocin signaling pathway TRPM4 218.7569082 204.0061496 233.5076667 1.14461092 0.194857276 0.715362122 1 2.542995764 3.036123628 54795 transient receptor potential cation channel subfamily M member 4 "GO:0002250,GO:0002407,GO:0002724,GO:0005227,GO:0005261,GO:0005509,GO:0005515,GO:0005516,GO:0005524,GO:0005654,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0007204,GO:0008284,GO:0010460,GO:0016925,GO:0019722,GO:0030502,GO:0034706,GO:0035774,GO:0042310,GO:0043025,GO:0044214,GO:0045600,GO:0045668,GO:0045907,GO:0051289,GO:0070588,GO:0070838,GO:0071318,GO:0086045,GO:0086047,GO:0086048,GO:0086091,GO:0089717,GO:0090263,GO:0098655,GO:0098662,GO:0098719,GO:0098911,GO:0099604,GO:1903949,GO:1904179,GO:1904199" adaptive immune response|dendritic cell chemotaxis|regulation of T cell cytokine production|calcium activated cation channel activity|cation channel activity|calcium ion binding|protein binding|calmodulin binding|ATP binding|nucleoplasm|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|positive regulation of cytosolic calcium ion concentration|positive regulation of cell population proliferation|positive regulation of heart rate|protein sumoylation|calcium-mediated signaling|negative regulation of bone mineralization|sodium channel complex|positive regulation of insulin secretion involved in cellular response to glucose stimulus|vasoconstriction|neuronal cell body|spanning component of plasma membrane|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of vasoconstriction|protein homotetramerization|calcium ion transmembrane transport|divalent metal ion transport|cellular response to ATP|membrane depolarization during AV node cell action potential|membrane depolarization during Purkinje myocyte cell action potential|membrane depolarization during bundle of His cell action potential|regulation of heart rate by cardiac conduction|spanning component of membrane|positive regulation of canonical Wnt signaling pathway|cation transmembrane transport|inorganic cation transmembrane transport|sodium ion import across plasma membrane|regulation of ventricular cardiac muscle cell action potential|ligand-gated calcium channel activity|positive regulation of atrial cardiac muscle cell action potential|positive regulation of adipose tissue development|positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization hsa04911 Insulin secretion TRPM6 10.98636634 10.14955968 11.823173 1.164895165 0.220200125 0.941332157 1 0.060768341 0.073838038 140803 transient receptor potential cation channel subfamily M member 6 "GO:0005261,GO:0005262,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0006468,GO:0009636,GO:0016324,GO:0031526,GO:0046872,GO:0051262,GO:0070588,GO:0070838,GO:0098655,GO:0106310,GO:0106311" cation channel activity|calcium channel activity|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|protein phosphorylation|response to toxic substance|apical plasma membrane|brush border membrane|metal ion binding|protein tetramerization|calcium ion transmembrane transport|divalent metal ion transport|cation transmembrane transport|protein serine kinase activity|protein threonine kinase activity hsa04978 Mineral absorption TRPM7 1336.38079 1237.231325 1435.530255 1.160276357 0.21446847 0.524674593 1 5.897543712 7.137539767 54822 transient receptor potential cation channel subfamily M member 7 "GO:0001726,GO:0003779,GO:0005261,GO:0005262,GO:0005524,GO:0005886,GO:0005887,GO:0006816,GO:0010961,GO:0016340,GO:0017022,GO:0031032,GO:0046777,GO:0046872,GO:0051262,GO:0070266,GO:0070588,GO:0070838,GO:0072507,GO:0098655,GO:0106310,GO:0106311" ruffle|actin binding|cation channel activity|calcium channel activity|ATP binding|plasma membrane|integral component of plasma membrane|calcium ion transport|cellular magnesium ion homeostasis|calcium-dependent cell-matrix adhesion|myosin binding|actomyosin structure organization|protein autophosphorylation|metal ion binding|protein tetramerization|necroptotic process|calcium ion transmembrane transport|divalent metal ion transport|divalent inorganic cation homeostasis|cation transmembrane transport|protein serine kinase activity|protein threonine kinase activity "hsa04217,hsa04218,hsa04621,hsa04978" Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Mineral absorption TRPM8 4.507918754 5.074779842 3.941057666 0.776596776 -0.364762376 0.977905494 1 0.028337342 0.022954648 79054 transient receptor potential cation channel subfamily M member 8 "GO:0005261,GO:0005515,GO:0005789,GO:0005886,GO:0005887,GO:0006874,GO:0009409,GO:0009897,GO:0016048,GO:0019722,GO:0042802,GO:0045121,GO:0050955,GO:0070588,GO:0070838,GO:0098655,GO:0099604,GO:0120162" cation channel activity|protein binding|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|response to cold|external side of plasma membrane|detection of temperature stimulus|calcium-mediated signaling|identical protein binding|membrane raft|thermoception|calcium ion transmembrane transport|divalent metal ion transport|cation transmembrane transport|ligand-gated calcium channel activity|positive regulation of cold-induced thermogenesis hsa04750 Inflammatory mediator regulation of TRP channels TRPS1 645.4422185 680.0204988 610.8639383 0.898302241 -0.154727161 0.68969342 1 3.40861434 3.193862975 7227 transcriptional repressor GATA binding 1 "GO:0000122,GO:0000785,GO:0000977,GO:0001227,GO:0001501,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008270,GO:0019904,GO:0032330,GO:0032991" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|zinc ion binding|protein domain specific binding|regulation of chondrocyte differentiation|protein-containing complex" TRPT1 505.3795327 568.3753423 442.383723 0.778330251 -0.361545663 0.375539477 1 28.13900878 22.84486706 83707 tRNA phosphotransferase 1 "GO:0000215,GO:0003674,GO:0003950,GO:0006388,GO:0008033,GO:0008150,GO:0045859" "tRNA 2'-phosphotransferase activity|molecular_function|NAD+ ADP-ribosyltransferase activity|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA processing|biological_process|regulation of protein kinase activity" TRPV1 78.21915748 59.88240213 96.55591282 1.61242551 0.689232514 0.350789887 1 0.612569666 1.030270055 7442 transient receptor potential cation channel subfamily V member 1 "GO:0004888,GO:0005216,GO:0005230,GO:0005231,GO:0005262,GO:0005515,GO:0005516,GO:0005524,GO:0005886,GO:0005887,GO:0007166,GO:0007635,GO:0015278,GO:0016021,GO:0031226,GO:0032591,GO:0034605,GO:0035091,GO:0045211,GO:0046872,GO:0050955,GO:0051209,GO:0051219,GO:0051289,GO:0060079,GO:0070588,GO:0071312,GO:0071318,GO:0071468,GO:0098703,GO:1901594" transmembrane signaling receptor activity|ion channel activity|extracellular ligand-gated ion channel activity|excitatory extracellular ligand-gated ion channel activity|calcium channel activity|protein binding|calmodulin binding|ATP binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|chemosensory behavior|calcium-release channel activity|integral component of membrane|intrinsic component of plasma membrane|dendritic spine membrane|cellular response to heat|phosphatidylinositol binding|postsynaptic membrane|metal ion binding|thermoception|release of sequestered calcium ion into cytosol|phosphoprotein binding|protein homotetramerization|excitatory postsynaptic potential|calcium ion transmembrane transport|cellular response to alkaloid|cellular response to ATP|cellular response to acidic pH|calcium ion import across plasma membrane|response to capsazepine "hsa04080,hsa04750" Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels TRPV2 1872.804317 1705.126027 2040.482607 1.196675539 0.259032039 0.424076062 1 25.77099909 32.16796584 51393 transient receptor potential cation channel subfamily V member 2 "GO:0005216,GO:0005261,GO:0005262,GO:0005886,GO:0005887,GO:0007600,GO:0009266,GO:0009408,GO:0009986,GO:0015075,GO:0032584,GO:0042470,GO:0044295,GO:0044297,GO:0045773,GO:0070588,GO:0090280,GO:0098703,GO:0120162" ion channel activity|cation channel activity|calcium channel activity|plasma membrane|integral component of plasma membrane|sensory perception|response to temperature stimulus|response to heat|cell surface|ion transmembrane transporter activity|growth cone membrane|melanosome|axonal growth cone|cell body|positive regulation of axon extension|calcium ion transmembrane transport|positive regulation of calcium ion import|calcium ion import across plasma membrane|positive regulation of cold-induced thermogenesis "hsa04621,hsa04750" NOD-like receptor signaling pathway|Inflammatory mediator regulation of TRP channels TRPV3 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.008668455 0.043886732 162514 transient receptor potential cation channel subfamily V member 3 "GO:0005216,GO:0005262,GO:0005886,GO:0005887,GO:0009408,GO:0042636,GO:0043235,GO:0070588,GO:0090280,GO:0098703" ion channel activity|calcium channel activity|plasma membrane|integral component of plasma membrane|response to heat|negative regulation of hair cycle|receptor complex|calcium ion transmembrane transport|positive regulation of calcium ion import|calcium ion import across plasma membrane hsa04750 Inflammatory mediator regulation of TRP channels TRPV4 64.5145303 65.97213794 63.05692266 0.955811417 -0.065202094 0.954818189 1 0.587318694 0.58554728 59341 transient receptor potential cation channel subfamily V member 4 "GO:0003779,GO:0005080,GO:0005216,GO:0005261,GO:0005262,GO:0005515,GO:0005516,GO:0005524,GO:0005783,GO:0005881,GO:0005886,GO:0005887,GO:0005912,GO:0005925,GO:0005929,GO:0006816,GO:0006874,GO:0006884,GO:0007015,GO:0007043,GO:0007204,GO:0007231,GO:0008017,GO:0008289,GO:0009612,GO:0010977,GO:0015275,GO:0016021,GO:0016324,GO:0019901,GO:0030027,GO:0030175,GO:0030426,GO:0030864,GO:0031117,GO:0031532,GO:0032587,GO:0034605,GO:0042169,GO:0042802,GO:0043014,GO:0043117,GO:0043622,GO:0046785,GO:0046872,GO:0048487,GO:0050891,GO:0051015,GO:0060351,GO:0070509,GO:0070588,GO:0071470,GO:0071476,GO:0097497,GO:0098703,GO:1902656" "actin binding|protein kinase C binding|ion channel activity|cation channel activity|calcium channel activity|protein binding|calmodulin binding|ATP binding|endoplasmic reticulum|cytoplasmic microtubule|plasma membrane|integral component of plasma membrane|adherens junction|focal adhesion|cilium|calcium ion transport|cellular calcium ion homeostasis|cell volume homeostasis|actin filament organization|cell-cell junction assembly|positive regulation of cytosolic calcium ion concentration|osmosensory signaling pathway|microtubule binding|lipid binding|response to mechanical stimulus|negative regulation of neuron projection development|stretch-activated, cation-selective, calcium channel activity|integral component of membrane|apical plasma membrane|protein kinase binding|lamellipodium|filopodium|growth cone|cortical actin cytoskeleton|positive regulation of microtubule depolymerization|actin cytoskeleton reorganization|ruffle membrane|cellular response to heat|SH2 domain binding|identical protein binding|alpha-tubulin binding|positive regulation of vascular permeability|cortical microtubule organization|microtubule polymerization|metal ion binding|beta-tubulin binding|multicellular organismal water homeostasis|actin filament binding|cartilage development involved in endochondral bone morphogenesis|calcium ion import|calcium ion transmembrane transport|cellular response to osmotic stress|cellular hypotonic response|blood vessel endothelial cell delamination|calcium ion import across plasma membrane|calcium ion import into cytosol" "hsa04218,hsa04750,hsa05418" Cellular senescence|Inflammatory mediator regulation of TRP channels|Fluid shear stress and atherosclerosis TRRAP 5003.861816 4930.656094 5077.067538 1.02969411 0.042215821 0.89595601 1 19.70180173 21.16070352 8295 transformation/transcription domain associated protein "GO:0000124,GO:0000125,GO:0000812,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0006281,GO:0006355,GO:0016301,GO:0016310,GO:0016573,GO:0016578,GO:0016579,GO:0030914,GO:0033276,GO:0035267,GO:0043967,GO:0043968,GO:1904837" "SAGA complex|PCAF complex|Swr1 complex|transcription coregulator activity|protein binding|nucleus|nucleoplasm|Golgi apparatus|DNA repair|regulation of transcription, DNA-templated|kinase activity|phosphorylation|histone acetylation|histone deubiquitination|protein deubiquitination|STAGA complex|transcription factor TFTC complex|NuA4 histone acetyltransferase complex|histone H4 acetylation|histone H2A acetylation|beta-catenin-TCF complex assembly" hsa05166 Human T-cell leukemia virus 1 infection other TRUB1 407.8965008 403.9524754 411.8405261 1.019527175 0.02790023 0.954522906 1 6.006684622 6.387774348 142940 TruB pseudouridine synthase family member 1 "GO:0003723,GO:0005634,GO:0005739,GO:0005829,GO:0006400,GO:0009982,GO:1990481" RNA binding|nucleus|mitochondrion|cytosol|tRNA modification|pseudouridine synthase activity|mRNA pseudouridine synthesis TRUB2 1237.742263 1330.607275 1144.877252 0.8604171 -0.216891898 0.524682641 1 11.49225177 10.31407047 26995 TruB pseudouridine synthase family member 2 "GO:0001522,GO:0003723,GO:0005759,GO:0006397,GO:0009982,GO:0070131" pseudouridine synthesis|RNA binding|mitochondrial matrix|mRNA processing|pseudouridine synthase activity|positive regulation of mitochondrial translation TSACC 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.180364699 0.0608768 128229 TSSK6 activating cochaperone "GO:0005515,GO:0005737,GO:0051087" protein binding|cytoplasm|chaperone binding TSC1 932.812575 1028.150396 837.4747541 0.81454499 -0.295933709 0.407200963 1 5.790302508 4.91962795 7248 TSC complex subunit 1 "GO:0001822,GO:0001843,GO:0001952,GO:0002250,GO:0005515,GO:0005634,GO:0005737,GO:0005811,GO:0005829,GO:0005884,GO:0005886,GO:0005938,GO:0006407,GO:0006417,GO:0006813,GO:0007160,GO:0008285,GO:0008344,GO:0010977,GO:0014069,GO:0016020,GO:0016239,GO:0016242,GO:0017148,GO:0021766,GO:0021987,GO:0030027,GO:0030030,GO:0030426,GO:0030544,GO:0032007,GO:0032780,GO:0032794,GO:0032868,GO:0032991,GO:0033596,GO:0034260,GO:0042030,GO:0042552,GO:0043379,GO:0043666,GO:0044877,GO:0045792,GO:0045859,GO:0046323,GO:0046627,GO:0047485,GO:0048471,GO:0050808,GO:0050821,GO:0051087,GO:0051492,GO:0051496,GO:0051726,GO:0051879,GO:0051894,GO:0055007,GO:0090630,GO:0090650,GO:0101031,GO:1901214,GO:1903204" kidney development|neural tube closure|regulation of cell-matrix adhesion|adaptive immune response|protein binding|nucleus|cytoplasm|lipid droplet|cytosol|actin filament|plasma membrane|cell cortex|rRNA export from nucleus|regulation of translation|potassium ion transport|cell-matrix adhesion|negative regulation of cell population proliferation|adult locomotory behavior|negative regulation of neuron projection development|postsynaptic density|membrane|positive regulation of macroautophagy|negative regulation of macroautophagy|negative regulation of translation|hippocampus development|cerebral cortex development|lamellipodium|cell projection organization|growth cone|Hsp70 protein binding|negative regulation of TOR signaling|negative regulation of ATPase activity|GTPase activating protein binding|response to insulin|protein-containing complex|TSC1-TSC2 complex|negative regulation of GTPase activity|ATPase inhibitor activity|myelination|memory T cell differentiation|regulation of phosphoprotein phosphatase activity|protein-containing complex binding|negative regulation of cell size|regulation of protein kinase activity|glucose import|negative regulation of insulin receptor signaling pathway|protein N-terminus binding|perinuclear region of cytoplasm|synapse organization|protein stabilization|chaperone binding|regulation of stress fiber assembly|positive regulation of stress fiber assembly|regulation of cell cycle|Hsp90 protein binding|positive regulation of focal adhesion assembly|cardiac muscle cell differentiation|activation of GTPase activity|cellular response to oxygen-glucose deprivation|chaperone complex|regulation of neuron death|negative regulation of oxidative stress-induced neuron death "hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04714,hsa04910,hsa05163,hsa05165,hsa05168,hsa05231" Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Thermogenesis|Insulin signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Choline metabolism in cancer TSC2 1401.571545 1248.395841 1554.747249 1.24539605 0.316604609 0.344002449 1 9.285775485 12.06261849 7249 TSC complex subunit 2 "GO:0001843,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005794,GO:0005829,GO:0006469,GO:0006606,GO:0006897,GO:0007507,GO:0008104,GO:0008285,GO:0014067,GO:0014069,GO:0016020,GO:0016032,GO:0016192,GO:0016239,GO:0019902,GO:0030100,GO:0030178,GO:0031267,GO:0032007,GO:0033596,GO:0042803,GO:0043276,GO:0043491,GO:0043547,GO:0046626,GO:0046627,GO:0048009,GO:0048471,GO:0050918,GO:0051056,GO:0051726,GO:0051879,GO:0051898,GO:1901525" neural tube closure|GTPase activator activity|protein binding|nucleus|cytoplasm|lysosome|Golgi apparatus|cytosol|negative regulation of protein kinase activity|protein import into nucleus|endocytosis|heart development|protein localization|negative regulation of cell population proliferation|negative regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|membrane|viral process|vesicle-mediated transport|positive regulation of macroautophagy|phosphatase binding|regulation of endocytosis|negative regulation of Wnt signaling pathway|small GTPase binding|negative regulation of TOR signaling|TSC1-TSC2 complex|protein homodimerization activity|anoikis|protein kinase B signaling|positive regulation of GTPase activity|regulation of insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|perinuclear region of cytoplasm|positive chemotaxis|regulation of small GTPase mediated signal transduction|regulation of cell cycle|Hsp90 protein binding|negative regulation of protein kinase B signaling|negative regulation of mitophagy "hsa04072,hsa04115,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04714,hsa04910,hsa04919,hsa05163,hsa05165,hsa05168,hsa05231" Phospholipase D signaling pathway|p53 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Thermogenesis|Insulin signaling pathway|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Choline metabolism in cancer TSC22D1 2169.511675 2152.721609 2186.30174 1.01559892 0.022330765 0.945974495 1 9.766886603 10.34652009 8848 TSC22 domain family member 1 "GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0006366" protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II TSC22D2 439.0159613 477.0293051 401.0026175 0.840624702 -0.250466244 0.555349008 1 2.117056734 1.856310299 9819 TSC22 domain family member 2 "GO:0006357,GO:0006970" regulation of transcription by RNA polymerase II|response to osmotic stress TSC22D3 175.3337666 165.4378228 185.2297103 1.119633389 0.163026416 0.779726728 1 2.432880981 2.841270841 1831 TSC22 domain family member 3 "GO:0005515,GO:0005634,GO:0005829,GO:0006357,GO:0006970,GO:0034220,GO:0070236" protein binding|nucleus|cytosol|regulation of transcription by RNA polymerase II|response to osmotic stress|ion transmembrane transport|negative regulation of activation-induced cell death of T cells TSC22D4 934.4040407 732.7982092 1136.009872 1.550235601 0.63248749 0.076628075 1 16.01106304 25.89010451 81628 TSC22 domain family member 4 "GO:0005515,GO:0005634,GO:0006357,GO:0006970,GO:0045892" "protein binding|nucleus|regulation of transcription by RNA polymerase II|response to osmotic stress|negative regulation of transcription, DNA-templated" TSC22 TSEN15 678.9412087 680.0204988 677.8619186 0.996825713 -0.004586812 0.994798729 1 9.569502444 9.950032962 116461 tRNA splicing endonuclease subunit 15 "GO:0003676,GO:0004518,GO:0005515,GO:0005654,GO:0005730,GO:0006388,GO:0006397,GO:0090305" "nucleic acid binding|nuclease activity|protein binding|nucleoplasm|nucleolus|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing|nucleic acid phosphodiester bond hydrolysis" TSEN2 280.731327 298.3970547 263.0655992 0.88159583 -0.181810694 0.711217275 1 3.678860306 3.382974735 80746 tRNA splicing endonuclease subunit 2 "GO:0000213,GO:0000214,GO:0000379,GO:0003676,GO:0005515,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0006388,GO:0006397,GO:0016829,GO:0090502" "tRNA-intron endonuclease activity|tRNA-intron endonuclease complex|tRNA-type intron splice site recognition and cleavage|nucleic acid binding|protein binding|nucleoplasm|nucleolus|centrosome|cytosol|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing|lyase activity|RNA phosphodiester bond hydrolysis, endonucleolytic" TSEN34 847.5914084 792.6806113 902.5022056 1.13854457 0.187190769 0.60767057 1 14.93544515 17.73716219 79042 tRNA splicing endonuclease subunit 34 "GO:0000213,GO:0000214,GO:0000379,GO:0003676,GO:0005654,GO:0005730,GO:0006388,GO:0006397,GO:0016829,GO:0090502" "tRNA-intron endonuclease activity|tRNA-intron endonuclease complex|tRNA-type intron splice site recognition and cleavage|nucleic acid binding|nucleoplasm|nucleolus|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing|lyase activity|RNA phosphodiester bond hydrolysis, endonucleolytic" TSEN54 357.2998817 279.1128913 435.4868721 1.560253524 0.64178047 0.152532542 1 7.297926326 11.87710447 283989 tRNA splicing endonuclease subunit 54 "GO:0000214,GO:0000379,GO:0005515,GO:0005654,GO:0005730,GO:0006388,GO:0006397" "tRNA-intron endonuclease complex|tRNA-type intron splice site recognition and cleavage|protein binding|nucleoplasm|nucleolus|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing" TSFM 596.3950034 593.7492415 599.0407653 1.008912051 0.012800418 0.978692479 1 12.73128893 13.39805061 10102 "Ts translation elongation factor, mitochondrial" "GO:0003723,GO:0003746,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0006414,GO:0032784,GO:0070125,GO:0070129" "RNA binding|translation elongation factor activity|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|translational elongation|regulation of DNA-templated transcription, elongation|mitochondrial translational elongation|regulation of mitochondrial translation" TSG101 1879.290929 1609.720166 2148.861692 1.334928727 0.416762718 0.198278259 1 51.79583713 72.12218332 7251 tumor susceptibility 101 "GO:0000122,GO:0000813,GO:0001558,GO:0003677,GO:0003714,GO:0005515,GO:0005730,GO:0005737,GO:0005768,GO:0005769,GO:0005770,GO:0005771,GO:0005815,GO:0005829,GO:0005886,GO:0006513,GO:0006858,GO:0007050,GO:0007175,GO:0008285,GO:0008333,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0030216,GO:0030374,GO:0031625,GO:0031901,GO:0031902,GO:0036258,GO:0039702,GO:0042059,GO:0042803,GO:0043130,GO:0043162,GO:0043405,GO:0043657,GO:0044877,GO:0045893,GO:0046755,GO:0046790,GO:0048306,GO:0051301,GO:0070062,GO:0075733,GO:0090543,GO:0097352,GO:1902186,GO:1902188,GO:1903543,GO:1903551,GO:1903774,GO:1990182,GO:2000397" "negative regulation of transcription by RNA polymerase II|ESCRT I complex|regulation of cell growth|DNA binding|transcription corepressor activity|protein binding|nucleolus|cytoplasm|endosome|early endosome|late endosome|multivesicular body|microtubule organizing center|cytosol|plasma membrane|protein monoubiquitination|extracellular transport|cell cycle arrest|negative regulation of epidermal growth factor-activated receptor activity|negative regulation of cell population proliferation|endosome to lysosome transport|endosome membrane|protein transport|endosomal transport|macroautophagy|viral life cycle|keratinocyte differentiation|nuclear receptor coactivator activity|ubiquitin protein ligase binding|early endosome membrane|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|negative regulation of epidermal growth factor receptor signaling pathway|protein homodimerization activity|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|regulation of MAP kinase activity|host cell|protein-containing complex binding|positive regulation of transcription, DNA-templated|viral budding|virion binding|calcium-dependent protein binding|cell division|extracellular exosome|intracellular transport of virus|Flemming body|autophagosome maturation|regulation of viral release from host cell|positive regulation of viral release from host cell|positive regulation of exosomal secretion|regulation of extracellular exosome assembly|positive regulation of viral budding via host ESCRT complex|exosomal secretion|positive regulation of ubiquitin-dependent endocytosis" hsa04144 Endocytosis TSGA10 47.82713993 36.53841486 59.11586499 1.617909951 0.694131313 0.424604743 1 0.278067891 0.469268193 80705 testis specific 10 "GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0005814,GO:0007283" molecular_function|protein binding|cellular_component|cytoplasm|centriole|spermatogenesis TSHZ1 473.1384741 519.6574558 426.6194924 0.820962901 -0.284611067 0.493535065 1 4.613289552 3.950482802 10194 teashirt zinc finger homeobox 1 "GO:0000785,GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0009952,GO:0042474,GO:0046872,GO:0060023" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|middle ear morphogenesis|metal ion binding|soft palate development" TSKU 1038.381604 1071.793503 1004.969705 0.937652358 -0.092874964 0.79287316 1 14.3377073 14.0228888 25987 "tsukushi, small leucine rich proteoglycan" "GO:0003431,GO:0005615,GO:0008203,GO:0010468,GO:0010977,GO:0021540,GO:0021670,GO:0021766,GO:0021960,GO:0030178,GO:0032911,GO:0033344,GO:0042060,GO:0042632,GO:0042635,GO:0043010,GO:0050431,GO:0060122,GO:0061073,GO:0097009,GO:0098868,GO:1904761" growth plate cartilage chondrocyte development|extracellular space|cholesterol metabolic process|regulation of gene expression|negative regulation of neuron projection development|corpus callosum morphogenesis|lateral ventricle development|hippocampus development|anterior commissure morphogenesis|negative regulation of Wnt signaling pathway|negative regulation of transforming growth factor beta1 production|cholesterol efflux|wound healing|cholesterol homeostasis|positive regulation of hair cycle|camera-type eye development|transforming growth factor beta binding|inner ear receptor cell stereocilium organization|ciliary body morphogenesis|energy homeostasis|bone growth|negative regulation of myofibroblast differentiation TSLP 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.074336861 0.075270663 85480 thymic stromal lymphopoietin "GO:0001961,GO:0005125,GO:0005139,GO:0005576,GO:0005615,GO:0008284,GO:0032722,GO:0032733,GO:0032736,GO:0032754,GO:0032755,GO:0033005,GO:0038111,GO:0042531,GO:0043066,GO:0050729,GO:0071654,GO:0071657,GO:1904894" positive regulation of cytokine-mediated signaling pathway|cytokine activity|interleukin-7 receptor binding|extracellular region|extracellular space|positive regulation of cell population proliferation|positive regulation of chemokine production|positive regulation of interleukin-10 production|positive regulation of interleukin-13 production|positive regulation of interleukin-5 production|positive regulation of interleukin-6 production|positive regulation of mast cell activation|interleukin-7-mediated signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of apoptotic process|positive regulation of inflammatory response|positive regulation of chemokine (C-C motif) ligand 1 production|positive regulation of granulocyte colony-stimulating factor production|positive regulation of receptor signaling pathway via STAT "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway TSN 1481.014737 1493.000229 1469.029245 0.98394442 -0.02335127 0.946064105 1 22.89981667 23.50274034 7247 translin "GO:0003677,GO:0003697,GO:0003723,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006310,GO:0030422,GO:0042802,GO:0043565,GO:0044877,GO:0090502" "DNA binding|single-stranded DNA binding|RNA binding|endoribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|DNA recombination|production of siRNA involved in RNA interference|identical protein binding|sequence-specific DNA binding|protein-containing complex binding|RNA phosphodiester bond hydrolysis, endonucleolytic" TSNARE1 647.6611662 562.2856065 733.0367259 1.303673289 0.382582364 0.31967264 1 2.304960125 3.134354496 203062 t-SNARE domain containing 1 "GO:0000149,GO:0005484,GO:0006886,GO:0006906,GO:0012505,GO:0016021,GO:0031201,GO:0048278" SNARE binding|SNAP receptor activity|intracellular protein transport|vesicle fusion|endomembrane system|integral component of membrane|SNARE complex|vesicle docking TSNAX 887.323149 881.9967365 892.6495614 1.012078077 0.017320592 0.965040609 1 16.95900653 17.90318729 7257 translin associated factor X "GO:0003677,GO:0003723,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0007275,GO:0007283,GO:0030154,GO:0030422,GO:0043565,GO:0046872,GO:0048471,GO:0090502" "DNA binding|RNA binding|endoribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|multicellular organism development|spermatogenesis|cell differentiation|production of siRNA involved in RNA interference|sequence-specific DNA binding|metal ion binding|perinuclear region of cytoplasm|RNA phosphodiester bond hydrolysis, endonucleolytic" TSNAXIP1 21.0913887 27.40381115 14.77896625 0.539303317 -0.890831188 0.42557567 1 0.451204928 0.253818256 55815 translin associated factor X interacting protein 1 "GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0007275,GO:0007283,GO:0008150,GO:0030154,GO:0048471" molecular_function|protein binding|cellular_component|cytoplasm|multicellular organism development|spermatogenesis|biological_process|cell differentiation|perinuclear region of cytoplasm TSPAN1 11.09028677 17.25425146 4.926322083 0.285513521 -1.808369028 0.192461091 1 0.458241724 0.136470015 10103 tetraspanin 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005765,GO:0005886,GO:0005887,GO:0016020,GO:0030054,GO:0031982,GO:0043231,GO:0048471,GO:0050821,GO:0070062" protein binding|nucleoplasm|cytoplasm|lysosomal membrane|plasma membrane|integral component of plasma membrane|membrane|cell junction|vesicle|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|protein stabilization|extracellular exosome TSPAN10 8.493513748 8.119647747 8.867379749 1.092089217 0.12709072 1 1 0.21792873 0.248249588 83882 tetraspanin 10 "GO:0005887,GO:0019899,GO:0072594" integral component of plasma membrane|enzyme binding|establishment of protein localization to organelle TSPAN12 164.0774547 170.5126027 157.6423066 0.924519972 -0.113223609 0.853370589 1 3.031190521 2.923112037 23554 tetraspanin 12 "GO:0001525,GO:0005515,GO:0005887,GO:0007166,GO:0010842,GO:0016020,GO:0016021,GO:0016055,GO:0042813,GO:0045765,GO:1900746" angiogenesis|protein binding|integral component of plasma membrane|cell surface receptor signaling pathway|retina layer formation|membrane|integral component of membrane|Wnt signaling pathway|Wnt-activated receptor activity|regulation of angiogenesis|regulation of vascular endothelial growth factor signaling pathway TSPAN13 352.2263396 437.4460224 267.0066569 0.610376237 -0.712229299 0.113987677 1 11.82866942 7.530944402 27075 tetraspanin 13 "GO:0005246,GO:0005887,GO:0016020,GO:1903169" calcium channel regulator activity|integral component of plasma membrane|membrane|regulation of calcium ion transmembrane transport TSPAN14 3713.027114 3877.131799 3548.922428 0.915347378 -0.127608738 0.688880331 1 42.63201214 40.70405746 81619 tetraspanin 14 "GO:0005515,GO:0005788,GO:0005886,GO:0005887,GO:0009986,GO:0019899,GO:0035579,GO:0043312,GO:0044267,GO:0045747,GO:0051604,GO:0070821,GO:0072659,GO:0097197" protein binding|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|cell surface|enzyme binding|specific granule membrane|neutrophil degranulation|cellular protein metabolic process|positive regulation of Notch signaling pathway|protein maturation|tertiary granule membrane|protein localization to plasma membrane|tetraspanin-enriched microdomain TSPAN15 576.4615852 645.5119959 507.4111745 0.786060023 -0.347288614 0.379376278 1 3.381558271 2.772608276 23555 tetraspanin 15 "GO:0005515,GO:0005788,GO:0005829,GO:0005886,GO:0005887,GO:0008593,GO:0009986,GO:0016604,GO:0019899,GO:0030054,GO:0031902,GO:0043231,GO:0044267,GO:0045746,GO:0051604,GO:0072659,GO:0097197" protein binding|endoplasmic reticulum lumen|cytosol|plasma membrane|integral component of plasma membrane|regulation of Notch signaling pathway|cell surface|nuclear body|enzyme binding|cell junction|late endosome membrane|intracellular membrane-bounded organelle|cellular protein metabolic process|negative regulation of Notch signaling pathway|protein maturation|protein localization to plasma membrane|tetraspanin-enriched microdomain TSPAN17 1017.162046 968.2679938 1066.056099 1.100992809 0.138805047 0.694384602 1 19.81388204 22.75464086 26262 tetraspanin 17 "GO:0000151,GO:0004842,GO:0005887,GO:0016567,GO:0019899,GO:0051604,GO:0072594,GO:0072659" ubiquitin ligase complex|ubiquitin-protein transferase activity|integral component of plasma membrane|protein ubiquitination|enzyme binding|protein maturation|establishment of protein localization to organelle|protein localization to plasma membrane TSPAN18 22.76228041 40.59823873 4.926322083 0.121343246 -3.042834281 0.009840511 0.418113748 0.429619216 0.054376999 90139 tetraspanin 18 GO:0005887 integral component of plasma membrane TSPAN2 101.3553039 92.36099312 110.3496147 1.194764271 0.256726001 0.712947134 1 1.455432007 1.813802842 10100 tetraspanin 2 "GO:0005515,GO:0005654,GO:0005887,GO:0006954,GO:0007420,GO:0014002,GO:0014005,GO:0016021,GO:0042552,GO:0043209,GO:0048709,GO:0061564" protein binding|nucleoplasm|integral component of plasma membrane|inflammatory response|brain development|astrocyte development|microglia development|integral component of membrane|myelination|myelin sheath|oligodendrocyte differentiation|axon development TSPAN3 4905.026581 4505.389544 5304.663619 1.177403989 0.23560942 0.462816089 1 36.25390631 44.52421185 10099 tetraspanin 3 "GO:0003674,GO:0005887,GO:0008150,GO:0070062" molecular_function|integral component of plasma membrane|biological_process|extracellular exosome TSPAN31 702.418808 735.8430771 668.9945388 0.909153812 -0.137403702 0.718165491 1 21.10297619 20.01229992 6302 tetraspanin 31 "GO:0005515,GO:0005887,GO:0008284,GO:0016020" protein binding|integral component of plasma membrane|positive regulation of cell population proliferation|membrane TSPAN33 216.1007521 190.8117221 241.3897821 1.265067887 0.339214806 0.521532251 1 4.632761543 6.113215536 340348 tetraspanin 33 "GO:0005515,GO:0005788,GO:0005886,GO:0005887,GO:0005912,GO:0009986,GO:0019899,GO:0044267,GO:0046930,GO:0046931,GO:0051604,GO:0072659,GO:0097197" protein binding|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|adherens junction|cell surface|enzyme binding|cellular protein metabolic process|pore complex|pore complex assembly|protein maturation|protein localization to plasma membrane|tetraspanin-enriched microdomain TSPAN4 2438.554924 2258.27703 2618.832819 1.159659681 0.213701487 0.503500565 1 43.87179318 53.06789648 7106 tetraspanin 4 "GO:0003823,GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0005925,GO:0031982,GO:0065003" antigen binding|integrin binding|protein binding|plasma membrane|integral component of plasma membrane|focal adhesion|vesicle|protein-containing complex assembly TSPAN5 381.3888794 343.0551173 419.7226414 1.223484566 0.290995903 0.509812166 1 5.191076028 6.624785402 10098 tetraspanin 5 "GO:0005515,GO:0005788,GO:0005886,GO:0005887,GO:0019899,GO:0044267,GO:0045747,GO:0051604,GO:0072659" protein binding|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|enzyme binding|cellular protein metabolic process|positive regulation of Notch signaling pathway|protein maturation|protein localization to plasma membrane TSPAN6 600.5612232 945.9389625 255.1834839 0.269767389 -1.890212138 2.85E-06 0.000941516 12.58761728 3.542002864 7105 tetraspanin 6 "GO:0005515,GO:0005887,GO:0039532,GO:0043123,GO:0070062,GO:1901223" protein binding|integral component of plasma membrane|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|extracellular exosome|negative regulation of NIK/NF-kappaB signaling TSPAN7 3.970749218 2.029911937 5.911586499 2.912237912 1.542128219 0.515744462 1 0.059017152 0.179275535 7102 tetraspanin 7 "GO:0005515,GO:0005887,GO:0016032" protein binding|integral component of plasma membrane|viral process hsa05202 Transcriptional misregulation in cancer TSPAN9 523.9510988 558.2257826 489.676415 0.877201359 -0.189020048 0.642114597 1 6.186469713 5.660543296 10867 tetraspanin 9 "GO:0003674,GO:0005886,GO:0005887,GO:0005925,GO:0008150,GO:0097197" molecular_function|plasma membrane|integral component of plasma membrane|focal adhesion|biological_process|tetraspanin-enriched microdomain TSPO 1663.713739 1589.421046 1738.006431 1.093483967 0.128932067 0.694871799 1 71.61794383 81.6864829 706 translocator protein "GO:0005497,GO:0005515,GO:0005739,GO:0005741,GO:0005783,GO:0005829,GO:0006626,GO:0006700,GO:0006783,GO:0006820,GO:0006821,GO:0006869,GO:0007568,GO:0008202,GO:0008347,GO:0008503,GO:0010042,GO:0010266,GO:0010940,GO:0014012,GO:0015485,GO:0016021,GO:0030325,GO:0031397,GO:0032374,GO:0032570,GO:0032720,GO:0033574,GO:0042127,GO:0042493,GO:0043065,GO:0043231,GO:0044325,GO:0045019,GO:0048266,GO:0050810,GO:0051901,GO:0051928,GO:0060242,GO:0060252,GO:0060253,GO:0070062,GO:0071222,GO:0071294,GO:0071476,GO:0072656,GO:1903147,GO:1903579,GO:2000379" androgen binding|protein binding|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|cytosol|protein targeting to mitochondrion|C21-steroid hormone biosynthetic process|heme biosynthetic process|anion transport|chloride transport|lipid transport|aging|steroid metabolic process|glial cell migration|benzodiazepine receptor activity|response to manganese ion|response to vitamin B1|positive regulation of necrotic cell death|peripheral nervous system axon regeneration|cholesterol binding|integral component of membrane|adrenal gland development|negative regulation of protein ubiquitination|regulation of cholesterol transport|response to progesterone|negative regulation of tumor necrosis factor production|response to testosterone|regulation of cell population proliferation|response to drug|positive regulation of apoptotic process|intracellular membrane-bounded organelle|ion channel binding|negative regulation of nitric oxide biosynthetic process|behavioral response to pain|regulation of steroid biosynthetic process|positive regulation of mitochondrial depolarization|positive regulation of calcium ion transport|contact inhibition|positive regulation of glial cell proliferation|negative regulation of glial cell proliferation|extracellular exosome|cellular response to lipopolysaccharide|cellular response to zinc ion|cellular hypotonic response|maintenance of protein location in mitochondrion|negative regulation of autophagy of mitochondrion|negative regulation of ATP metabolic process|positive regulation of reactive oxygen species metabolic process "hsa04080,hsa04979,hsa05166" Neuroactive ligand-receptor interaction|Cholesterol metabolism|Human T-cell leukemia virus 1 infection TSPOAP1 7.911806884 2.029911937 13.79370183 6.795221794 2.764520641 0.100891817 1 0.013355141 0.094660339 9256 TSPO associated protein 1 "GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006700,GO:0007269,GO:0007274,GO:0008150,GO:0014047,GO:0030156,GO:0044305,GO:0098978,GO:0099509,GO:0099626" protein binding|cytoplasm|mitochondrion|cytosol|C21-steroid hormone biosynthetic process|neurotransmitter secretion|neuromuscular synaptic transmission|biological_process|glutamate secretion|benzodiazepine receptor binding|calyx of Held|glutamatergic synapse|regulation of presynaptic cytosolic calcium ion concentration|voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels TSPYL1 1597.531038 1476.760934 1718.301142 1.163560806 0.218546606 0.507018732 1 14.74329423 17.89367505 7259 TSPY like 1 "GO:0003682,GO:0005634,GO:0005654,GO:0005730,GO:0006334,GO:0008150,GO:0019899,GO:0042393" chromatin binding|nucleus|nucleoplasm|nucleolus|nucleosome assembly|biological_process|enzyme binding|histone binding TSPYL2 655.0330819 594.7641975 715.3019664 1.202664803 0.266234602 0.488235344 1 7.054498454 8.849661792 64061 TSPY like 2 "GO:0000182,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006334,GO:0007049,GO:0008156,GO:0009966,GO:0030308,GO:0036498,GO:0042393,GO:0045786,GO:0045859" rDNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|nucleosome assembly|cell cycle|negative regulation of DNA replication|regulation of signal transduction|negative regulation of cell growth|IRE1-mediated unfolded protein response|histone binding|negative regulation of cell cycle|regulation of protein kinase activity TSPYL4 525.0214785 429.3263746 620.7165824 1.445791871 0.531859884 0.187897813 1 5.287905229 7.974535052 23270 TSPY like 4 "GO:0003682,GO:0005515,GO:0005634,GO:0006334,GO:0042393" chromatin binding|protein binding|nucleus|nucleosome assembly|histone binding TSR1 2086.101447 2411.535381 1760.667512 0.730102293 -0.453829483 0.158178374 1 28.77167483 21.91113052 55720 TSR1 ribosome maturation factor "GO:0000462,GO:0000479,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005730,GO:0005829,GO:0030688,GO:0034511" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|GTPase activity|protein binding|GTP binding|nucleoplasm|nucleolus|cytosol|preribosome, small subunit precursor|U3 snoRNA binding" TSR2 1562.818654 1528.523688 1597.113619 1.044873319 0.06332804 0.849417478 1 18.99272142 20.69982946 90121 TSR2 ribosome maturation factor "GO:0000462,GO:0005515" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|protein binding" TSR3 692.4825323 662.7662473 722.1988173 1.089673501 0.123895925 0.746063965 1 27.74113416 31.53091198 115939 TSR3 ribosome maturation factor "GO:0000154,GO:0000455,GO:0005829,GO:0016740,GO:0030490,GO:1904047" rRNA modification|enzyme-directed rRNA pseudouridine synthesis|cytosol|transferase activity|maturation of SSU-rRNA|S-adenosyl-L-methionine binding TSSC4 549.0402067 623.1829646 474.8974488 0.762051397 -0.39203979 0.326503247 1 6.115485119 4.861061404 10078 tumor suppressing subtransferable candidate 4 GO:0005515 protein binding TSSK6 35.54102627 38.5683268 32.51372575 0.843016238 -0.246367675 0.817715771 1 1.468683979 1.291457821 83983 testis specific serine kinase 6 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007275,GO:0018105,GO:0035092,GO:0035556,GO:0044877,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|multicellular organism development|peptidyl-serine phosphorylation|sperm chromatin condensation|intracellular signal transduction|protein-containing complex binding|protein serine kinase activity|protein threonine kinase activity TST 264.6526134 310.5765263 218.7287005 0.704266684 -0.505806258 0.304635335 1 13.64232906 10.02170455 7263 thiosulfate sulfurtransferase "GO:0000098,GO:0004792,GO:0005615,GO:0005739,GO:0005759,GO:0008097,GO:0009440,GO:0019346,GO:0030855,GO:0035928,GO:0051029" sulfur amino acid catabolic process|thiosulfate sulfurtransferase activity|extracellular space|mitochondrion|mitochondrial matrix|5S rRNA binding|cyanate catabolic process|transsulfuration|epithelial cell differentiation|rRNA import into mitochondrion|rRNA transport "hsa00270,hsa00920,hsa04122" Cysteine and methionine metabolism|Sulfur metabolism|Sulfur relay system TSTD1 39.95987037 37.55337083 42.36636991 1.128164236 0.173977108 0.87355416 1 2.912627492 3.42746637 100131187 thiosulfate sulfurtransferase like domain containing 1 "GO:0005737,GO:0005829,GO:0036464,GO:0048471,GO:0050337,GO:0070221" "cytoplasm|cytosol|cytoplasmic ribonucleoprotein granule|perinuclear region of cytoplasm|thiosulfate-thiol sulfurtransferase activity|sulfide oxidation, using sulfide:quinone oxidoreductase" TSTD2 680.5918114 759.1870643 601.9965585 0.792948914 -0.334700171 0.378872652 1 9.341629387 7.726517134 158427 thiosulfate sulfurtransferase like domain containing 2 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process TSTD3 65.42556584 60.8973581 69.95377357 1.148716065 0.200022243 0.813393972 1 3.649983852 4.373403696 100130890 thiosulfate sulfurtransferase like domain containing 3 TTBK2 1071.591843 951.0137424 1192.169944 1.253578041 0.326051813 0.349431113 1 3.860342316 5.047695206 146057 tau tubulin kinase 2 "GO:0000226,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005814,GO:0005829,GO:0007026,GO:0007224,GO:0018105,GO:0019894,GO:0021549,GO:0021681,GO:0021935,GO:0030334,GO:0035869,GO:0036064,GO:0048156,GO:0050321,GO:0051010,GO:0060271,GO:0097711,GO:0106310,GO:0106311,GO:1902817,GO:1904527" microtubule cytoskeleton organization|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|extracellular space|nucleus|cytoplasm|centriole|cytosol|negative regulation of microtubule depolymerization|smoothened signaling pathway|peptidyl-serine phosphorylation|kinesin binding|cerebellum development|cerebellar granular layer development|cerebellar granule cell precursor tangential migration|regulation of cell migration|ciliary transition zone|ciliary basal body|tau protein binding|tau-protein kinase activity|microtubule plus-end binding|cilium assembly|ciliary basal body-plasma membrane docking|protein serine kinase activity|protein threonine kinase activity|negative regulation of protein localization to microtubule|negative regulation of microtubule binding TTC1 929.1617519 946.9539185 911.3695853 0.962422318 -0.055257997 0.879785301 1 33.3517909 33.48118145 7265 tetratricopeptide repeat domain 1 "GO:0005515,GO:0005778,GO:0005829,GO:0006457,GO:0051082" protein binding|peroxisomal membrane|cytosol|protein folding|unfolded protein binding TTC12 168.615065 177.6172945 159.6128355 0.898633413 -0.15419539 0.794903913 1 2.369781182 2.221297555 54970 tetratricopeptide repeat domain 12 "GO:0005737,GO:0005813,GO:0007288,GO:0070286" cytoplasm|centrosome|sperm axoneme assembly|axonemal dynein complex assembly TTC13 510.9226964 509.5078961 512.3374966 1.005553595 0.007989978 0.989777602 1 6.290779498 6.598202128 79573 tetratricopeptide repeat domain 13 TTC14 605.9331646 605.9287131 605.9376162 1.000014693 2.12E-05 1 1 6.645333853 6.931689731 151613 tetratricopeptide repeat domain 14 GO:0003676 nucleic acid binding TTC17 2000.127351 1888.833057 2111.421645 1.1178445 0.160719513 0.618558539 1 16.83906547 19.6342949 55761 tetratricopeptide repeat domain 17 "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0015629,GO:0030041,GO:0044782" protein binding|cytoplasm|cytosol|plasma membrane|actin cytoskeleton|actin filament polymerization|cilium organization TTC19 1394.416873 1298.128684 1490.705062 1.148349221 0.199561442 0.551642962 1 15.25420842 18.27172649 54902 tetratricopeptide repeat domain 19 "GO:0000281,GO:0005515,GO:0005739,GO:0005743,GO:0005813,GO:0030496,GO:0034551,GO:0055114,GO:0070469" mitotic cytokinesis|protein binding|mitochondrion|mitochondrial inner membrane|centrosome|midbody|mitochondrial respiratory chain complex III assembly|oxidation-reduction process|respirasome TTC21A 118.7580131 137.0190557 100.4969705 0.733452511 -0.447224536 0.488350307 1 1.557345556 1.191442033 199223 tetratricopeptide repeat domain 21A "GO:0005929,GO:0007286,GO:0030317,GO:0030991,GO:0035721,GO:0061512" cilium|spermatid development|flagellated sperm motility|intraciliary transport particle A|intraciliary retrograde transport|protein localization to cilium TTC21B 559.0400708 464.8498335 653.2303082 1.405250171 0.490826991 0.217188125 1 1.275559635 1.869693181 79809 tetratricopeptide repeat domain 21B "GO:0005737,GO:0005856,GO:0005929,GO:0006357,GO:0030991,GO:0035721,GO:0035735,GO:0061512,GO:0097542,GO:1905799" cytoplasm|cytoskeleton|cilium|regulation of transcription by RNA polymerase II|intraciliary transport particle A|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|protein localization to cilium|ciliary tip|regulation of intraciliary retrograde transport TTC22 5.941278051 2.029911937 9.852644165 4.853729853 2.279093814 0.221443742 1 0.016274795 0.082396175 55001 tetratricopeptide repeat domain 22 TTC23 627.3620468 521.6873677 733.0367259 1.405126463 0.490699981 0.204991487 1 5.555429936 8.142335954 64927 tetratricopeptide repeat domain 23 "GO:0005515,GO:0005929,GO:0045880" protein binding|cilium|positive regulation of smoothened signaling pathway TTC23L 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.023175807 0.023466936 153657 tetratricopeptide repeat domain 23 like "GO:0005515,GO:0005737,GO:0005815,GO:0005819,GO:0030496,GO:0034976" protein binding|cytoplasm|microtubule organizing center|spindle|midbody|response to endoplasmic reticulum stress TTC26 411.1046722 421.2067269 401.0026175 0.952032795 -0.070916823 0.874350652 1 4.405748614 4.375095648 79989 tetratricopeptide repeat domain 26 "GO:0005813,GO:0005929,GO:0007224,GO:0030992,GO:0035082,GO:0035720,GO:0035735,GO:0036064,GO:0042073,GO:0060271,GO:0061512,GO:0097542,GO:0097546,GO:0120170,GO:1905198" centrosome|cilium|smoothened signaling pathway|intraciliary transport particle B|axoneme assembly|intraciliary anterograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|cilium assembly|protein localization to cilium|ciliary tip|ciliary base|intraciliary transport particle B binding|manchette assembly TTC27 315.5421886 320.726086 310.3582912 0.96767399 -0.047407011 0.925838077 1 5.595468413 5.647827788 55622 tetratricopeptide repeat domain 27 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process TTC28 1540.477498 1449.357123 1631.597874 1.125739025 0.170872412 0.605848879 1 4.537043405 5.327538358 23331 tetratricopeptide repeat domain 28 "GO:0000922,GO:0005737,GO:0005815,GO:0007049,GO:0007346,GO:0019900,GO:0030496,GO:0051301" spindle pole|cytoplasm|microtubule organizing center|cell cycle|regulation of mitotic cell cycle|kinase binding|midbody|cell division TTC3 5335.98327 5509.180996 5162.785543 0.937123966 -0.09368819 0.771515525 1 21.65468236 21.1672672 7267 tetratricopeptide repeat domain 3 "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005794,GO:0005829,GO:0006511,GO:0046872,GO:0070936" ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|Golgi apparatus|cytosol|ubiquitin-dependent protein catabolic process|metal ion binding|protein K48-linked ubiquitination TTC30A 225.1205489 335.9504255 114.2906723 0.340201005 -1.555540693 0.003241203 0.198783986 2.962169897 1.051142234 92104 tetratricopeptide repeat domain 30A "GO:0005879,GO:0030992,GO:0036064,GO:0042073,GO:0120170" axonemal microtubule|intraciliary transport particle B|ciliary basal body|intraciliary transport|intraciliary transport particle B binding TTC30B 124.3254252 147.1686154 101.4822349 0.689564379 -0.536242844 0.397078791 1 1.961982414 1.411191198 150737 tetratricopeptide repeat domain 30B "GO:0005515,GO:0005879,GO:0005929,GO:0030992,GO:0035735,GO:0036064,GO:0042073,GO:0097542,GO:0120170" protein binding|axonemal microtubule|cilium|intraciliary transport particle B|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|ciliary tip|intraciliary transport particle B binding TTC31 613.9273652 512.552764 715.3019664 1.395567474 0.480851879 0.21649586 1 7.997224067 11.64142201 64427 tetratricopeptide repeat domain 31 TTC32 68.41105064 62.92727004 73.89483124 1.17428948 0.231788099 0.777056938 1 3.386869536 4.148485418 130502 tetratricopeptide repeat domain 32 GO:0005515 protein binding TTC33 446.2057684 362.3392807 530.0722561 1.462916897 0.548847817 0.192410957 1 3.261277112 4.976491749 23548 tetratricopeptide repeat domain 33 GO:0005515 protein binding TTC34 19.58380052 25.37389921 13.79370183 0.543617743 -0.879335549 0.443480744 1 0.181511085 0.102923064 100287898 tetratricopeptide repeat domain 34 TTC36 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.108447129 0.164714126 143941 tetratricopeptide repeat domain 36 "GO:0006570,GO:0007613,GO:0008542,GO:0010801,GO:0021954,GO:0032091,GO:0032435,GO:0060271,GO:1902915" tyrosine metabolic process|memory|visual learning|negative regulation of peptidyl-threonine phosphorylation|central nervous system neuron development|negative regulation of protein binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|cilium assembly|negative regulation of protein polyubiquitination TTC37 1924.454986 1902.027485 1946.882487 1.023582731 0.033627713 0.918712525 1 16.96864227 18.11698705 9652 tetratricopeptide repeat domain 37 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0034427,GO:0035327,GO:0043928,GO:0055087" "protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|transcriptionally active chromatin|exonucleolytic catabolism of deadenylated mRNA|Ski complex" hsa03018 RNA degradation TTC38 671.2169537 758.1721084 584.261799 0.770618957 -0.375910419 0.324296062 1 9.009559507 7.242010929 55020 tetratricopeptide repeat domain 38 GO:0070062 extracellular exosome TTC39A 36.70444 50.74779842 22.66108158 0.446543146 -1.163128515 0.213998427 1 0.575760968 0.268177031 22996 tetratricopeptide repeat domain 39A "GO:0003674,GO:0005575,GO:0005813,GO:0008150" molecular_function|cellular_component|centrosome|biological_process TTC39B 317.7260015 267.9483757 367.5036274 1.37154639 0.45580342 0.327092923 1 1.119874564 1.602122839 158219 tetratricopeptide repeat domain 39B "GO:0005515,GO:0006629,GO:0010874,GO:0010887,GO:0042632,GO:0090181" protein binding|lipid metabolic process|regulation of cholesterol efflux|negative regulation of cholesterol storage|cholesterol homeostasis|regulation of cholesterol metabolic process TTC39C 338.9334348 336.9653815 340.9014881 1.011681042 0.016754515 0.977869138 1 1.815929754 1.916278319 125488 tetratricopeptide repeat domain 39C "GO:0032474,GO:0060271" otolith morphogenesis|cilium assembly TTC4 661.0579914 669.8709391 652.2450438 0.973687625 -0.038469089 0.923892246 1 14.40008485 14.62516018 7268 tetratricopeptide repeat domain 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0045087,GO:0051607,GO:0051879" protein binding|nucleus|nucleoplasm|cytoplasm|innate immune response|defense response to virus|Hsp90 protein binding TTC5 330.6774535 345.0850292 316.2698777 0.916498402 -0.12579573 0.789023281 1 3.689537544 3.52711464 91875 tetratricopeptide repeat domain 5 "GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0005737,GO:0006281,GO:0045944,GO:1901796" DNA binding|chromatin binding|protein binding|nucleoplasm|cytoplasm|DNA repair|positive regulation of transcription by RNA polymerase II|regulation of signal transduction by p53 class mediator TTC6 9.463932389 7.104691779 11.823173 1.664135949 0.734773297 0.648013687 1 0.036298555 0.063007764 319089 tetratricopeptide repeat domain 6 TTC7A 497.446199 463.8348775 531.0575205 1.144927961 0.195256826 0.635611871 1 3.056812002 3.650587995 57217 tetratricopeptide repeat domain 7A "GO:0005737,GO:0005886,GO:0006879,GO:0030097,GO:0046854,GO:0072659" cytoplasm|plasma membrane|cellular iron ion homeostasis|hemopoiesis|phosphatidylinositol phosphorylation|protein localization to plasma membrane TTC7B 1111.72046 932.7445349 1290.696386 1.383761938 0.468595764 0.176104535 1 2.426557436 3.502417272 145567 tetratricopeptide repeat domain 7B "GO:0005515,GO:0005829,GO:0005886,GO:0046854,GO:0072659" protein binding|cytosol|plasma membrane|phosphatidylinositol phosphorylation|protein localization to plasma membrane TTC8 616.5577892 658.7064235 574.4091548 0.872026041 -0.197556876 0.612940272 1 9.757577237 8.875388693 123016 tetratricopeptide repeat domain 8 "GO:0001103,GO:0005515,GO:0005813,GO:0005829,GO:0005929,GO:0015031,GO:0034464,GO:0036064,GO:0048560,GO:0050893,GO:0060170,GO:0060271,GO:0097730,GO:1905515" RNA polymerase II repressing transcription factor binding|protein binding|centrosome|cytosol|cilium|protein transport|BBSome|ciliary basal body|establishment of anatomical structure orientation|sensory processing|ciliary membrane|cilium assembly|non-motile cilium|non-motile cilium assembly TTC9 15.52397665 17.25425146 13.79370183 0.799437858 -0.3229422 0.834216248 1 0.171548286 0.143049724 23508 tetratricopeptide repeat domain 9 TTC9C 513.035002 418.161859 607.908145 1.453762776 0.539791871 0.183913311 1 20.70227074 31.39261242 283237 tetratricopeptide repeat domain 9C GO:0005515 protein binding TTF1 344.1121351 354.219633 334.0046372 0.9429309 -0.084776044 0.857387201 1 5.583558916 5.491701213 7270 transcription termination factor 1 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006353,GO:0006363,GO:0008156,GO:0044267" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|DNA-templated transcription, termination|termination of RNA polymerase I transcription|negative regulation of DNA replication|cellular protein metabolic process" hsa04918 Thyroid hormone synthesis TTF2 936.5269867 877.9369126 995.1170607 1.133472174 0.180748974 0.613425837 1 4.987594778 5.896821127 8458 transcription termination factor 2 "GO:0003677,GO:0004386,GO:0005515,GO:0005524,GO:0005681,GO:0005829,GO:0006353,GO:0006369,GO:0006397,GO:0008023,GO:0008094,GO:0008270,GO:0008380" "DNA binding|helicase activity|protein binding|ATP binding|spliceosomal complex|cytosol|DNA-templated transcription, termination|termination of RNA polymerase II transcription|mRNA processing|transcription elongation factor complex|DNA-dependent ATPase activity|zinc ion binding|RNA splicing" hsa04918 Thyroid hormone synthesis other TTI1 1608.204159 1667.572656 1548.835663 0.92879651 -0.106565544 0.74706883 1 20.14230198 19.51396884 9675 TELO2 interacting protein 1 "GO:0005515,GO:0005737,GO:0031931,GO:0031932,GO:0032006,GO:0070209" protein binding|cytoplasm|TORC1 complex|TORC2 complex|regulation of TOR signaling|ASTRA complex hsa04150 mTOR signaling pathway TTI2 208.4561691 207.0510175 209.8613207 1.013572999 0.019449997 0.980925922 1 4.194561443 4.434631348 80185 TELO2 interacting protein 2 "GO:0005654,GO:0005813,GO:0005829,GO:0070209" nucleoplasm|centrosome|cytosol|ASTRA complex TTK 960.0397207 868.8023089 1051.277132 1.210030316 0.275043193 0.438870541 1 12.39137482 15.63981728 7272 TTK protein kinase "GO:0000776,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0007051,GO:0007052,GO:0007059,GO:0007094,GO:0008284,GO:0010862,GO:0016020,GO:0016321,GO:0018105,GO:0018107,GO:0018108,GO:0033316,GO:0034501,GO:0043515,GO:0046777,GO:0051304,GO:1903096" kinetochore|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|spindle|spindle organization|mitotic spindle organization|chromosome segregation|mitotic spindle assembly checkpoint|positive regulation of cell population proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|membrane|female meiosis chromosome segregation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|meiotic spindle assembly checkpoint|protein localization to kinetochore|kinetochore binding|protein autophosphorylation|chromosome separation|protein localization to meiotic spindle midzone hsa04110 Cell cycle TTL 1689.609962 1642.198757 1737.021166 1.057741129 0.080986586 0.805792585 1 5.769393292 6.365396581 150465 tubulin tyrosine ligase "GO:0000226,GO:0004835,GO:0005524,GO:0005876,GO:0018166,GO:0018215,GO:0030516,GO:0045931,GO:0090235" microtubule cytoskeleton organization|tubulin-tyrosine ligase activity|ATP binding|spindle microtubule|C-terminal protein-tyrosinylation|protein phosphopantetheinylation|regulation of axon extension|positive regulation of mitotic cell cycle|regulation of metaphase plate congression TTLL1 72.08216274 78.15160956 66.01271591 0.844675065 -0.243531631 0.760162614 1 1.968226416 1.734126041 25809 tubulin tyrosine ligase like 1 "GO:0000226,GO:0002395,GO:0005524,GO:0005576,GO:0005737,GO:0005874,GO:0005929,GO:0007288,GO:0015631,GO:0018095,GO:0018215,GO:0021702,GO:0036064,GO:0070740,GO:0120197,GO:0120222" microtubule cytoskeleton organization|immune response in nasopharyngeal-associated lymphoid tissue|ATP binding|extracellular region|cytoplasm|microtubule|cilium|sperm axoneme assembly|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|cerebellar Purkinje cell differentiation|ciliary basal body|tubulin-glutamic acid ligase activity|mucociliary clearance|regulation of blastocyst development TTLL11 141.1370249 117.7348923 164.5391576 1.397539458 0.482889016 0.426764031 1 0.427108155 0.622612552 158135 tubulin tyrosine ligase like 11 "GO:0000226,GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0015631,GO:0018095,GO:0018215,GO:0036064,GO:0051013,GO:0070740" microtubule cytoskeleton organization|ATP binding|cytosol|microtubule|cilium|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|ciliary basal body|microtubule severing|tubulin-glutamic acid ligase activity TTLL12 1550.996719 1697.006379 1404.987058 0.827920905 -0.272435147 0.409539497 1 25.38316197 21.9205022 23170 tubulin tyrosine ligase like 12 "GO:0004835,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005819,GO:0007346,GO:0015631,GO:0018024,GO:0018215,GO:0030496,GO:0034968,GO:0045087,GO:0060339,GO:0070510,GO:1990889" tubulin-tyrosine ligase activity|protein binding|ATP binding|nucleus|cytoplasm|microtubule organizing center|spindle|regulation of mitotic cell cycle|tubulin binding|histone-lysine N-methyltransferase activity|protein phosphopantetheinylation|midbody|histone lysine methylation|innate immune response|negative regulation of type I interferon-mediated signaling pathway|regulation of histone H4-K20 methylation|H4K20me3 modified histone binding TTLL3 81.21948806 62.92727004 99.51170607 1.5813765 0.661180891 0.364963518 1 0.722194478 1.191256749 26140 tubulin tyrosine ligase like 3 "GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0005930,GO:0015630,GO:0018094,GO:0018215,GO:0035082,GO:0060271,GO:0070735,GO:0070736" "ATP binding|cytosol|microtubule|cilium|axoneme|microtubule cytoskeleton|protein polyglycylation|protein phosphopantetheinylation|axoneme assembly|cilium assembly|protein-glycine ligase activity|protein-glycine ligase activity, initiating" TTLL4 588.2456641 575.4800341 601.0112941 1.044365153 0.062626226 0.877347919 1 3.624227002 3.948059545 9654 tubulin tyrosine ligase like 4 "GO:0000226,GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0015631,GO:0018095,GO:0018200,GO:0018215,GO:0036064,GO:0070739,GO:0070740,GO:0097731,GO:0120222" microtubule cytoskeleton organization|ATP binding|cytosol|microtubule|cilium|tubulin binding|protein polyglutamylation|peptidyl-glutamic acid modification|protein phosphopantetheinylation|ciliary basal body|protein-glutamic acid ligase activity|tubulin-glutamic acid ligase activity|9+0 non-motile cilium|regulation of blastocyst development TTLL5 1178.237933 967.2530379 1389.222827 1.436255843 0.522312762 0.12815801 1 10.38760689 15.56192236 23093 tubulin tyrosine ligase like 5 "GO:0000226,GO:0005524,GO:0005634,GO:0005813,GO:0005829,GO:0005874,GO:0005886,GO:0005929,GO:0015631,GO:0018095,GO:0018215,GO:0060041,GO:0070740" microtubule cytoskeleton organization|ATP binding|nucleus|centrosome|cytosol|microtubule|plasma membrane|cilium|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|retina development in camera-type eye|tubulin-glutamic acid ligase activity TTLL6 11.01605789 12.17947162 9.852644165 0.808954975 -0.305868687 0.884333199 1 0.148673722 0.125451106 284076 tubulin tyrosine ligase like 6 "GO:0000226,GO:0001578,GO:0003353,GO:0005515,GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0015631,GO:0018095,GO:0018215,GO:0036064,GO:0051013,GO:0070739,GO:0070740,GO:0097731" microtubule cytoskeleton organization|microtubule bundle formation|positive regulation of cilium movement|protein binding|ATP binding|cytosol|microtubule|cilium|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|ciliary basal body|microtubule severing|protein-glutamic acid ligase activity|tubulin-glutamic acid ligase activity|9+0 non-motile cilium TTLL7 523.2412232 476.0143492 570.4680972 1.198426262 0.261141144 0.519471449 1 3.02035173 3.775589487 79739 tubulin tyrosine ligase like 7 "GO:0000226,GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0007399,GO:0015631,GO:0018095,GO:0018215,GO:0030154,GO:0030425,GO:0043014,GO:0043204,GO:0048487,GO:0070740" microtubule cytoskeleton organization|ATP binding|cytosol|microtubule|cilium|nervous system development|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|cell differentiation|dendrite|alpha-tubulin binding|perikaryon|beta-tubulin binding|tubulin-glutamic acid ligase activity TTLL9 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.066396202 0.026892102 164395 tubulin tyrosine ligase like 9 "GO:0000226,GO:0005524,GO:0005737,GO:0005874,GO:0005929,GO:0015631,GO:0018095,GO:0018215,GO:0030317,GO:0036064,GO:0070740" microtubule cytoskeleton organization|ATP binding|cytoplasm|microtubule|cilium|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|flagellated sperm motility|ciliary basal body|tubulin-glutamic acid ligase activity TTPA 15.47943932 14.20938356 16.74949508 1.178762964 0.237273638 0.895884728 1 0.231922381 0.285157681 7274 alpha tocopherol transfer protein "GO:0005515,GO:0005546,GO:0005770,GO:0005829,GO:0006629,GO:0007584,GO:0008431,GO:0009268,GO:0032502,GO:0042360,GO:0043325,GO:0051180,GO:0051452,GO:0060548,GO:0120009,GO:0120013,GO:1902936" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|late endosome|cytosol|lipid metabolic process|response to nutrient|vitamin E binding|response to pH|developmental process|vitamin E metabolic process|phosphatidylinositol-3,4-bisphosphate binding|vitamin transport|intracellular pH reduction|negative regulation of cell death|intermembrane lipid transfer|lipid transfer activity|phosphatidylinositol bisphosphate binding" TTPAL 1293.748434 1387.444809 1200.052059 0.86493679 -0.209333391 0.536594189 1 9.586519093 8.648907284 79183 alpha tocopherol transfer protein like "GO:0016020,GO:1902936" membrane|phosphatidylinositol bisphosphate binding TTYH2 3.492962786 3.044867905 3.941057666 1.294327961 0.372203218 1 1 0.03706124 0.050035726 94015 tweety family member 2 "GO:0005229,GO:0005515,GO:0005886,GO:0034707,GO:0072320,GO:1902476" intracellular calcium activated chloride channel activity|protein binding|plasma membrane|chloride channel complex|volume-sensitive chloride channel activity|chloride transmembrane transport TTYH3 2456.66182 2822.592548 2090.731092 0.740713035 -0.43301337 0.17518779 1 76.52802733 59.12708051 80727 tweety family member 3 "GO:0005229,GO:0005254,GO:0005886,GO:0006821,GO:0034220,GO:0034707,GO:0070062,GO:0072320,GO:1902476" intracellular calcium activated chloride channel activity|chloride channel activity|plasma membrane|chloride transport|ion transmembrane transport|chloride channel complex|extracellular exosome|volume-sensitive chloride channel activity|chloride transmembrane transport TUBA1A 5435.928963 4393.744387 6478.113539 1.474394723 0.560122813 0.083075978 1 99.69876927 153.3273024 7846 tubulin alpha 1a "GO:0000086,GO:0000226,GO:0000278,GO:0003924,GO:0005198,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005874,GO:0005881,GO:0007017,GO:0010389,GO:0015630,GO:0019904,GO:0030705,GO:0031594,GO:0036464,GO:0042802,GO:0043209,GO:0045121,GO:0050807,GO:0051301,GO:0055037,GO:0070062,GO:0097711" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|cytosol|microtubule|cytoplasmic microtubule|microtubule-based process|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|protein domain specific binding|cytoskeleton-dependent intracellular transport|neuromuscular junction|cytoplasmic ribonucleoprotein granule|identical protein binding|myelin sheath|membrane raft|regulation of synapse organization|cell division|recycling endosome|extracellular exosome|ciliary basal body-plasma membrane docking "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBA1B 33692.41336 29053.11459 38331.71213 1.319366707 0.399845605 0.314971423 1 904.3870688 1244.617189 10376 tubulin alpha 1b "GO:0000226,GO:0000278,GO:0003725,GO:0003924,GO:0005198,GO:0005200,GO:0005515,GO:0005525,GO:0005737,GO:0005874,GO:0005881,GO:0007017,GO:0015630,GO:0030705,GO:0031625,GO:0045121,GO:0051301,GO:0071353" microtubule cytoskeleton organization|mitotic cell cycle|double-stranded RNA binding|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|cytoplasm|microtubule|cytoplasmic microtubule|microtubule-based process|microtubule cytoskeleton|cytoskeleton-dependent intracellular transport|ubiquitin protein ligase binding|membrane raft|cell division|cellular response to interleukin-4 "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBA1C 13244.20591 12884.86602 13603.5458 1.055777047 0.078305207 0.820862928 1 197.9293323 217.9707937 84790 tubulin alpha 1c "GO:0000226,GO:0000278,GO:0003924,GO:0005198,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007017,GO:0015630,GO:0030705,GO:0031982,GO:0051301" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|microtubule|microtubule-based process|microtubule cytoskeleton|cytoskeleton-dependent intracellular transport|vesicle|cell division "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBA3C 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.102662059 7278 tubulin alpha 3c "GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005525,GO:0005634,GO:0005737,GO:0005874" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|GTP binding|nucleus|cytoplasm|microtubule "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBA4A 517.4347949 651.6017317 383.267858 0.588193431 -0.765637423 0.05934441 1 12.25448533 7.518499511 7277 tubulin alpha 4a "GO:0000086,GO:0000226,GO:0000278,GO:0002576,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005576,GO:0005737,GO:0005829,GO:0005856,GO:0005874,GO:0010389,GO:0015630,GO:0019901,GO:0070062,GO:0097711" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|platelet degranulation|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|extracellular region|cytoplasm|cytosol|cytoskeleton|microtubule|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|protein kinase binding|extracellular exosome|ciliary basal body-plasma membrane docking "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBA8 7.971189988 6.08973581 9.852644165 1.617909951 0.694131313 0.702268135 1 0.156242976 0.263676108 51807 tubulin alpha 8 "GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005737,GO:0005874,GO:0015630" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|cytoplasm|microtubule|microtubule cytoskeleton "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBAL3 23.24006684 39.58328277 6.896850916 0.174236456 -2.520881578 0.025452789 0.708392419 1.118100184 0.203205603 79861 tubulin alpha like 3 "GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB 34286.54414 30872.93065 37700.15763 1.221139582 0.288228117 0.469953278 1 589.5946546 750.9910754 203068 tubulin beta class I "GO:0000086,GO:0000226,GO:0000278,GO:0003924,GO:0005198,GO:0005200,GO:0005515,GO:0005525,GO:0005576,GO:0005634,GO:0005641,GO:0005737,GO:0005856,GO:0005874,GO:0007017,GO:0009987,GO:0010389,GO:0019904,GO:0030705,GO:0031625,GO:0032794,GO:0032991,GO:0035578,GO:0036464,GO:0042267,GO:0042288,GO:0043312,GO:0044297,GO:0044877,GO:0045121,GO:0050807,GO:0051225,GO:0051301,GO:0070062,GO:0097711" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|extracellular region|nucleus|nuclear envelope lumen|cytoplasm|cytoskeleton|microtubule|microtubule-based process|cellular process|regulation of G2/M transition of mitotic cell cycle|protein domain specific binding|cytoskeleton-dependent intracellular transport|ubiquitin protein ligase binding|GTPase activating protein binding|protein-containing complex|azurophil granule lumen|cytoplasmic ribonucleoprotein granule|natural killer cell mediated cytotoxicity|MHC class I protein binding|neutrophil degranulation|cell body|protein-containing complex binding|membrane raft|regulation of synapse organization|spindle assembly|cell division|extracellular exosome|ciliary basal body-plasma membrane docking "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB2A 554.0813356 496.3134685 611.8492027 1.232787828 0.301924522 0.449481213 1 14.38016378 18.4913279 7280 tubulin beta 2A class IIa "GO:0000226,GO:0000278,GO:0001764,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0070062,GO:1903561" microtubule cytoskeleton organization|mitotic cell cycle|neuron migration|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|microtubule|extracellular exosome|extracellular vesicle "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB2B 8.478667972 7.104691779 9.852644165 1.386779958 0.471738892 0.817532793 1 0.187215179 0.270809905 347733 tubulin beta 2B class IIb "GO:0000226,GO:0000278,GO:0001764,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007017,GO:0015630,GO:0046982,GO:0050804,GO:0098685,GO:1902669,GO:1990403" microtubule cytoskeleton organization|mitotic cell cycle|neuron migration|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|microtubule|microtubule-based process|microtubule cytoskeleton|protein heterodimerization activity|modulation of chemical synaptic transmission|Schaffer collateral - CA1 synapse|positive regulation of axon guidance|embryonic brain development "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB3 1777.271525 1606.675298 1947.867752 1.212359307 0.277817334 0.393438548 1 40.14427027 50.76575488 10381 tubulin beta 3 class III "GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007411,GO:0030027,GO:0030175,GO:0030424,GO:0030425,GO:0030426,GO:0038007,GO:0070062,GO:1990791,GO:1990890" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|microtubule|axon guidance|lamellipodium|filopodium|axon|dendrite|growth cone|netrin-activated signaling pathway|extracellular exosome|dorsal root ganglion development|netrin receptor binding "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB4A 53.96141307 51.76275439 56.16007174 1.084951379 0.117630391 0.909246181 1 1.071353045 1.212435975 10382 tubulin beta 4A class IVa "GO:0000086,GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005509,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005874,GO:0005930,GO:0010389,GO:0031115,GO:0033269,GO:0043025,GO:0043209,GO:0070062,GO:0097711" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|calcium ion binding|protein binding|GTP binding|nucleus|cytoplasm|cytosol|microtubule|axoneme|regulation of G2/M transition of mitotic cell cycle|negative regulation of microtubule polymerization|internode region of axon|neuronal cell body|myelin sheath|extracellular exosome|ciliary basal body-plasma membrane docking "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB4B 13749.34716 12527.60152 14971.09281 1.195048612 0.257069306 0.458903197 1 405.9365465 506.0106462 10383 tubulin beta 4B class IVb "GO:0000086,GO:0000226,GO:0000278,GO:0003725,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005874,GO:0010389,GO:0035578,GO:0042267,GO:0042288,GO:0043312,GO:0051082,GO:0070062,GO:0097711,GO:1903561" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|double-stranded RNA binding|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|extracellular region|nucleus|cytoplasm|cytosol|cytoskeleton|microtubule|regulation of G2/M transition of mitotic cell cycle|azurophil granule lumen|natural killer cell mediated cytotoxicity|MHC class I protein binding|neutrophil degranulation|unfolded protein binding|extracellular exosome|ciliary basal body-plasma membrane docking|extracellular vesicle "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB6 10980.4117 9944.538578 12016.28482 1.208330053 0.273014577 0.421120717 1 161.0152803 202.9404407 84617 tubulin beta 6 class V "GO:0000226,GO:0000278,GO:0003674,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0070062" microtubule cytoskeleton organization|mitotic cell cycle|molecular_function|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|microtubule|extracellular exosome "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBD1 261.8034622 284.1876711 239.4192532 0.842468824 -0.247304795 0.620189478 1 5.501950684 4.834888487 51174 tubulin delta 1 "GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005525,GO:0005654,GO:0005737,GO:0005814,GO:0005829,GO:0005874,GO:0005929,GO:0007275,GO:0030030,GO:0045880" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|GTP binding|nucleoplasm|cytoplasm|centriole|cytosol|microtubule|cilium|multicellular organism development|cell projection organization|positive regulation of smoothened signaling pathway TUBE1 155.7202745 138.0340117 173.4065373 1.256259491 0.329134496 0.578282185 1 3.032943921 3.974291025 51175 tubulin epsilon 1 "GO:0000226,GO:0000242,GO:0000278,GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874,GO:0007098" microtubule cytoskeleton organization|pericentriolar material|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule|centrosome cycle TUBG1 3014.896506 2727.186687 3302.606324 1.210993857 0.276191546 0.385440647 1 72.65775106 91.77826026 7283 tubulin gamma 1 "GO:0000070,GO:0000086,GO:0000212,GO:0000226,GO:0000278,GO:0000794,GO:0000930,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005827,GO:0005829,GO:0005874,GO:0007020,GO:0007052,GO:0010389,GO:0031122,GO:0042802,GO:0055037,GO:0097711,GO:1990498" mitotic sister chromatid segregation|G2/M transition of mitotic cell cycle|meiotic spindle organization|microtubule cytoskeleton organization|mitotic cell cycle|condensed nuclear chromosome|gamma-tubulin complex|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|centrosome|spindle|polar microtubule|cytosol|microtubule|microtubule nucleation|mitotic spindle organization|regulation of G2/M transition of mitotic cell cycle|cytoplasmic microtubule organization|identical protein binding|recycling endosome|ciliary basal body-plasma membrane docking|mitotic spindle microtubule hsa05165 Human papillomavirus infection TUBG2 723.5898687 701.3345741 745.8451633 1.063465557 0.088773308 0.815874536 1 16.8023283 18.63840843 27175 tubulin gamma 2 "GO:0000070,GO:0000212,GO:0000226,GO:0000242,GO:0000278,GO:0000930,GO:0003924,GO:0005198,GO:0005200,GO:0005525,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0005876,GO:0005881,GO:0007020,GO:0007052,GO:0015630,GO:0031122" mitotic sister chromatid segregation|meiotic spindle organization|microtubule cytoskeleton organization|pericentriolar material|mitotic cell cycle|gamma-tubulin complex|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|GTP binding|nucleus|cytoplasm|centrosome|spindle|cytosol|microtubule|spindle microtubule|cytoplasmic microtubule|microtubule nucleation|mitotic spindle organization|microtubule cytoskeleton|cytoplasmic microtubule organization hsa05165 Human papillomavirus infection TUBGCP2 1564.493505 1676.70726 1452.27975 0.866149855 -0.207311444 0.530166793 1 21.16105349 19.11816703 10844 tubulin gamma complex associated protein 2 "GO:0000278,GO:0000922,GO:0000923,GO:0000930,GO:0001764,GO:0005515,GO:0005654,GO:0005813,GO:0005815,GO:0005829,GO:0005881,GO:0007020,GO:0007420,GO:0008275,GO:0016020,GO:0031122,GO:0043015,GO:0051011,GO:0051225,GO:0051321,GO:0065003" mitotic cell cycle|spindle pole|equatorial microtubule organizing center|gamma-tubulin complex|neuron migration|protein binding|nucleoplasm|centrosome|microtubule organizing center|cytosol|cytoplasmic microtubule|microtubule nucleation|brain development|gamma-tubulin small complex|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|microtubule minus-end binding|spindle assembly|meiotic cell cycle|protein-containing complex assembly TUBGCP3 735.3591018 630.2876564 840.4305473 1.333407911 0.415118192 0.266922783 1 5.521855436 7.680048978 10426 tubulin gamma complex associated protein 3 "GO:0000278,GO:0000923,GO:0000930,GO:0005198,GO:0005200,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0005827,GO:0005829,GO:0007020,GO:0007338,GO:0008275,GO:0016020,GO:0031122,GO:0043015,GO:0051011,GO:0051225,GO:0051321" mitotic cell cycle|equatorial microtubule organizing center|gamma-tubulin complex|structural molecule activity|structural constituent of cytoskeleton|protein binding|cytoplasm|centrosome|centriole|spindle|polar microtubule|cytosol|microtubule nucleation|single fertilization|gamma-tubulin small complex|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|microtubule minus-end binding|spindle assembly|meiotic cell cycle TUBGCP4 460.3354799 452.6703619 468.0005979 1.033866224 0.048049522 0.91355003 1 3.326970963 3.587808774 27229 tubulin gamma complex associated protein 4 "GO:0000278,GO:0000922,GO:0000923,GO:0000930,GO:0005200,GO:0005515,GO:0005813,GO:0005829,GO:0005874,GO:0007020,GO:0008274,GO:0015630,GO:0016020,GO:0031122,GO:0043015,GO:0051011,GO:0051225,GO:0051321,GO:0055037,GO:0065003" mitotic cell cycle|spindle pole|equatorial microtubule organizing center|gamma-tubulin complex|structural constituent of cytoskeleton|protein binding|centrosome|cytosol|microtubule|microtubule nucleation|gamma-tubulin ring complex|microtubule cytoskeleton|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|microtubule minus-end binding|spindle assembly|meiotic cell cycle|recycling endosome|protein-containing complex assembly TUBGCP5 428.537073 467.8947014 389.1794445 0.831767155 -0.265748379 0.533954689 1 4.115529002 3.570617778 114791 tubulin gamma complex associated protein 5 "GO:0000278,GO:0000922,GO:0000923,GO:0000930,GO:0005515,GO:0005813,GO:0005829,GO:0005874,GO:0007020,GO:0008017,GO:0008274,GO:0031122,GO:0043015,GO:0051011,GO:0051225,GO:0051321" mitotic cell cycle|spindle pole|equatorial microtubule organizing center|gamma-tubulin complex|protein binding|centrosome|cytosol|microtubule|microtubule nucleation|microtubule binding|gamma-tubulin ring complex|cytoplasmic microtubule organization|gamma-tubulin binding|microtubule minus-end binding|spindle assembly|meiotic cell cycle TUBGCP6 1243.36114 1074.838371 1411.883909 1.313577881 0.393501739 0.247563631 1 8.974080393 12.29593935 85378 tubulin gamma complex associated protein 6 "GO:0000278,GO:0000922,GO:0000923,GO:0000930,GO:0005813,GO:0005829,GO:0005874,GO:0007020,GO:0008017,GO:0008274,GO:0008275,GO:0016020,GO:0031122,GO:0043015,GO:0051011,GO:0051225,GO:0051321" mitotic cell cycle|spindle pole|equatorial microtubule organizing center|gamma-tubulin complex|centrosome|cytosol|microtubule|microtubule nucleation|microtubule binding|gamma-tubulin ring complex|gamma-tubulin small complex|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|microtubule minus-end binding|spindle assembly|meiotic cell cycle TUFM 3022.579937 3151.438282 2893.721591 0.918222517 -0.123084284 0.699337979 1 79.36809118 76.01683854 7284 "Tu translation elongation factor, mitochondrial" "GO:0003723,GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0006414,GO:0016020,GO:0016032,GO:0042645,GO:0045202,GO:0045471,GO:0070062,GO:0070125" RNA binding|translation elongation factor activity|GTPase activity|protein binding|GTP binding|mitochondrion|translational elongation|membrane|viral process|mitochondrial nucleoid|synapse|response to ethanol|extracellular exosome|mitochondrial translational elongation TUFT1 268.0592231 274.0381115 262.0803348 0.956364549 -0.064367443 0.902989448 1 3.797281422 3.788019301 7286 tuftelin 1 "GO:0005515,GO:0005576,GO:0005622,GO:0005737,GO:0030282,GO:0030345,GO:0035556,GO:0042476" protein binding|extracellular region|intracellular anatomical structure|cytoplasm|bone mineralization|structural constituent of tooth enamel|intracellular signal transduction|odontogenesis TULP3 740.5202347 680.0204988 801.0199707 1.177935036 0.236259975 0.527801936 1 17.43829838 21.42601347 7289 TUB like protein 3 "GO:0001664,GO:0001843,GO:0005515,GO:0005546,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005886,GO:0005929,GO:0005930,GO:0006355,GO:0007186,GO:0007420,GO:0008277,GO:0009952,GO:0019899,GO:0021914,GO:0021953,GO:0031076,GO:0035091,GO:0042733,GO:0044877,GO:0045879,GO:0048702,GO:0060348,GO:0060434,GO:0060831,GO:0061512,GO:0061548,GO:0097546,GO:0097731,GO:0120160,GO:1901621" "G protein-coupled receptor binding|neural tube closure|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|nucleus|nucleoplasm|nucleolus|plasma membrane|cilium|axoneme|regulation of transcription, DNA-templated|G protein-coupled receptor signaling pathway|brain development|regulation of G protein-coupled receptor signaling pathway|anterior/posterior pattern specification|enzyme binding|negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning|central nervous system neuron differentiation|embryonic camera-type eye development|phosphatidylinositol binding|embryonic digit morphogenesis|protein-containing complex binding|negative regulation of smoothened signaling pathway|embryonic neurocranium morphogenesis|bone development|bronchus morphogenesis|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|protein localization to cilium|ganglion development|ciliary base|9+0 non-motile cilium|intraciliary transport particle A binding|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" TULP4 582.6606847 597.8090654 567.5123039 0.949320338 -0.075033104 0.852685436 1 2.550924275 2.525958909 56995 TUB like protein 4 "GO:0005737,GO:0005829,GO:0016567,GO:0043687" cytoplasm|cytosol|protein ubiquitination|post-translational protein modification TUSC1 555.5565106 529.8070155 581.3060058 1.0972033 0.133830866 0.739824412 1 18.17944193 20.80575988 286319 tumor suppressor candidate 1 TUSC2 664.5009737 736.858033 592.1439143 0.803606513 -0.315438839 0.409520934 1 22.36025158 18.74286872 11334 "tumor suppressor 2, mitochondrial calcium regulator" "GO:0001779,GO:0005515,GO:0005739,GO:0006909,GO:0006954,GO:0007049,GO:0032700,GO:0032733,GO:0048469,GO:0051881,GO:0070945,GO:2000377" natural killer cell differentiation|protein binding|mitochondrion|phagocytosis|inflammatory response|cell cycle|negative regulation of interleukin-17 production|positive regulation of interleukin-10 production|cell maturation|regulation of mitochondrial membrane potential|neutrophil-mediated killing of gram-negative bacterium|regulation of reactive oxygen species metabolic process TUSC3 1760.303302 1726.440102 1794.166503 1.039228931 0.0555135 0.86619995 1 9.325735992 10.10904838 7991 tumor suppressor candidate 3 "GO:0005739,GO:0005789,GO:0005886,GO:0005887,GO:0006487,GO:0008250,GO:0015095,GO:0015693,GO:0018279,GO:0050890,GO:0055085,GO:1903830" mitochondrion|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|protein N-linked glycosylation|oligosaccharyltransferase complex|magnesium ion transmembrane transporter activity|magnesium ion transport|protein N-linked glycosylation via asparagine|cognition|transmembrane transport|magnesium ion transmembrane transport "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum TUT1 497.0196309 569.3902983 424.6489635 0.745795924 -0.423147183 0.3014256 1 10.66085394 8.293310557 64852 "terminal uridylyl transferase 1, U6 snRNA-specific" "GO:0003723,GO:0003730,GO:0004652,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005847,GO:0006378,GO:0006397,GO:0016180,GO:0016607,GO:0016779,GO:0017070,GO:0019899,GO:0034477,GO:0046872,GO:0050265,GO:0071044,GO:0098789" RNA binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|mRNA cleavage and polyadenylation specificity factor complex|mRNA polyadenylation|mRNA processing|snRNA processing|nuclear speck|nucleotidyltransferase activity|U6 snRNA binding|enzyme binding|U6 snRNA 3'-end processing|metal ion binding|RNA uridylyltransferase activity|histone mRNA catabolic process|pre-mRNA cleavage required for polyadenylation TUT4 1826.267522 1588.406091 2064.128953 1.299497002 0.377953306 0.244436521 1 11.20746237 15.19142456 23318 terminal uridylyl transferase 4 "GO:0000289,GO:0001556,GO:0003723,GO:0004652,GO:0005515,GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006378,GO:0006397,GO:0008270,GO:0010526,GO:0010586,GO:0010587,GO:0016779,GO:0019827,GO:0031054,GO:0031123,GO:0035198,GO:0036464,GO:0050265,GO:0070062,GO:0071044,GO:0071076,GO:1990074" "nuclear-transcribed mRNA poly(A) tail shortening|oocyte maturation|RNA binding|polynucleotide adenylyltransferase activity|protein binding|extracellular space|nucleus|nucleolus|cytoplasm|cytosol|mRNA polyadenylation|mRNA processing|zinc ion binding|negative regulation of transposition, RNA-mediated|miRNA metabolic process|miRNA catabolic process|nucleotidyltransferase activity|stem cell population maintenance|pre-miRNA processing|RNA 3'-end processing|miRNA binding|cytoplasmic ribonucleoprotein granule|RNA uridylyltransferase activity|extracellular exosome|histone mRNA catabolic process|RNA 3' uridylation|polyuridylation-dependent mRNA catabolic process" TUT7 821.8503242 851.5480575 792.1525909 0.930250012 -0.104309591 0.777728594 1 3.868667477 3.753850881 79670 terminal uridylyl transferase 7 "GO:0000289,GO:0001556,GO:0003723,GO:0004652,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006378,GO:0006397,GO:0008270,GO:0010526,GO:0010586,GO:0016779,GO:0031054,GO:0031123,GO:0035198,GO:0050265,GO:0070569,GO:0071044,GO:0071076,GO:1990074" "nuclear-transcribed mRNA poly(A) tail shortening|oocyte maturation|RNA binding|polynucleotide adenylyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA polyadenylation|mRNA processing|zinc ion binding|negative regulation of transposition, RNA-mediated|miRNA metabolic process|nucleotidyltransferase activity|pre-miRNA processing|RNA 3'-end processing|miRNA binding|RNA uridylyltransferase activity|uridylyltransferase activity|histone mRNA catabolic process|RNA 3' uridylation|polyuridylation-dependent mRNA catabolic process" TVP23B 545.1315622 591.7193296 498.5437948 0.842534239 -0.24719278 0.538034757 1 9.438896561 8.295159003 51030 trans-golgi network vesicle protein 23 homolog B "GO:0005515,GO:0009306,GO:0016192,GO:0030173" protein binding|protein secretion|vesicle-mediated transport|integral component of Golgi membrane TVP23C 142.5676626 148.1835714 136.9517539 0.924203355 -0.113717767 0.86081654 1 1.48672249 1.433221723 201158 trans-golgi network vesicle protein 23 homolog C "GO:0009306,GO:0016192,GO:0030173" protein secretion|vesicle-mediated transport|integral component of Golgi membrane TWF1 2317.178365 2380.071746 2254.284985 0.947150013 -0.078335152 0.807449155 1 40.07388216 39.59096761 5756 twinfilin actin binding protein 1 "GO:0003779,GO:0003785,GO:0004713,GO:0005515,GO:0005524,GO:0005546,GO:0005730,GO:0005737,GO:0005829,GO:0005884,GO:0005911,GO:0005925,GO:0010591,GO:0010976,GO:0015629,GO:0018108,GO:0030016,GO:0030042,GO:0030175,GO:0030837,GO:0032587,GO:0042989,GO:0043538,GO:0045296,GO:0048471,GO:0051015,GO:0051016" "actin binding|actin monomer binding|protein tyrosine kinase activity|protein binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|nucleolus|cytoplasm|cytosol|actin filament|cell-cell junction|focal adhesion|regulation of lamellipodium assembly|positive regulation of neuron projection development|actin cytoskeleton|peptidyl-tyrosine phosphorylation|myofibril|actin filament depolymerization|filopodium|negative regulation of actin filament polymerization|ruffle membrane|sequestering of actin monomers|regulation of actin phosphorylation|cadherin binding|perinuclear region of cytoplasm|actin filament binding|barbed-end actin filament capping" TWF2 2385.463969 2333.383771 2437.544167 1.044639204 0.063004753 0.844713633 1 73.22035708 79.78368526 11344 twinfilin actin binding protein 2 "GO:0003723,GO:0003785,GO:0005080,GO:0005515,GO:0005524,GO:0005546,GO:0005737,GO:0005884,GO:0010591,GO:0010592,GO:0010976,GO:0030016,GO:0030027,GO:0030030,GO:0030042,GO:0030175,GO:0030426,GO:0030837,GO:0032420,GO:0032532,GO:0032956,GO:0042989,GO:0045296,GO:0045773,GO:0048471,GO:0051015,GO:0051016,GO:0070062,GO:0071300,GO:0071363" "RNA binding|actin monomer binding|protein kinase C binding|protein binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|actin filament|regulation of lamellipodium assembly|positive regulation of lamellipodium assembly|positive regulation of neuron projection development|myofibril|lamellipodium|cell projection organization|actin filament depolymerization|filopodium|growth cone|negative regulation of actin filament polymerization|stereocilium|regulation of microvillus length|regulation of actin cytoskeleton organization|sequestering of actin monomers|cadherin binding|positive regulation of axon extension|perinuclear region of cytoplasm|actin filament binding|barbed-end actin filament capping|extracellular exosome|cellular response to retinoic acid|cellular response to growth factor stimulus" TWNK 543.1583117 625.2128765 461.1037469 0.737514796 -0.439256102 0.272739843 1 17.82929424 13.71578976 56652 twinkle mtDNA helicase "GO:0002020,GO:0003678,GO:0003697,GO:0005524,GO:0005739,GO:0005759,GO:0006264,GO:0006268,GO:0006390,GO:0007005,GO:0034214,GO:0042645,GO:0042802,GO:0043139,GO:0071333" protease binding|DNA helicase activity|single-stranded DNA binding|ATP binding|mitochondrion|mitochondrial matrix|mitochondrial DNA replication|DNA unwinding involved in DNA replication|mitochondrial transcription|mitochondrion organization|protein hexamerization|mitochondrial nucleoid|identical protein binding|5'-3' DNA helicase activity|cellular response to glucose stimulus hsa05017 Spinocerebellar ataxia TWSG1 1866.082647 2121.257974 1610.907321 0.759411321 -0.397046588 0.220556259 1 28.64912881 22.69365338 57045 twisted gastrulation BMP signaling modulator 1 "GO:0001503,GO:0001707,GO:0001818,GO:0005515,GO:0005615,GO:0007179,GO:0007435,GO:0010862,GO:0030097,GO:0030154,GO:0030509,GO:0030510,GO:0030513,GO:0030514,GO:0030900,GO:0043010,GO:0045668,GO:0050431,GO:2000515,GO:2000562" "ossification|mesoderm formation|negative regulation of cytokine production|protein binding|extracellular space|transforming growth factor beta receptor signaling pathway|salivary gland morphogenesis|positive regulation of pathway-restricted SMAD protein phosphorylation|hemopoiesis|cell differentiation|BMP signaling pathway|regulation of BMP signaling pathway|positive regulation of BMP signaling pathway|negative regulation of BMP signaling pathway|forebrain development|camera-type eye development|negative regulation of osteoblast differentiation|transforming growth factor beta binding|negative regulation of CD4-positive, alpha-beta T cell activation|negative regulation of CD4-positive, alpha-beta T cell proliferation" TXK 31.30033148 51.76275439 10.83790858 0.209376582 -2.255828005 0.026574621 0.720384826 0.440235248 0.096145475 7294 TXK tyrosine kinase "GO:0001816,GO:0002250,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0006468,GO:0007202,GO:0007229,GO:0010468,GO:0010543,GO:0032729,GO:0038083,GO:0042246,GO:0045944,GO:0046777,GO:0050852,GO:0060335" cytokine production|adaptive immune response|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|protein phosphorylation|activation of phospholipase C activity|integrin-mediated signaling pathway|regulation of gene expression|regulation of platelet activation|positive regulation of interferon-gamma production|peptidyl-tyrosine autophosphorylation|tissue regeneration|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|T cell receptor signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway hsa04670 Leukocyte transendothelial migration TXLNA 2203.30758 2173.020728 2233.594432 1.027875346 0.039665314 0.902819428 1 21.17680083 22.70475036 200081 taxilin alpha "GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006887,GO:0016020,GO:0019221,GO:0019905,GO:0042113" protein binding|extracellular region|cytoplasm|cytosol|exocytosis|membrane|cytokine-mediated signaling pathway|syntaxin binding|B cell activation TXLNB 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.028104942 0 167838 taxilin beta "GO:0005515,GO:0005737,GO:0019905" protein binding|cytoplasm|syntaxin binding TXLNG 1023.266628 981.4624214 1065.070834 1.085187584 0.117944447 0.738657933 1 5.265636573 5.960348143 55787 taxilin gamma "GO:0005829,GO:0007049,GO:0008134,GO:0010564,GO:0019905,GO:0030500,GO:0031965,GO:0033613,GO:0051726" cytosol|cell cycle|transcription factor binding|regulation of cell cycle process|syntaxin binding|regulation of bone mineralization|nuclear membrane|activating transcription factor binding|regulation of cell cycle TXN 3632.666205 3536.106594 3729.225817 1.054613518 0.076714395 0.810119807 1 243.0004401 267.3106881 7295 thioredoxin "GO:0000122,GO:0003723,GO:0004791,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006662,GO:0009314,GO:0015035,GO:0015037,GO:0032148,GO:0033138,GO:0042803,GO:0043388,GO:0045454,GO:0046826,GO:0047134,GO:0051897,GO:0055114,GO:0070062,GO:0071731,GO:0098869,GO:1903206,GO:2000170" negative regulation of transcription by RNA polymerase II|RNA binding|thioredoxin-disulfide reductase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|glycerol ether metabolic process|response to radiation|protein disulfide oxidoreductase activity|peptide disulfide oxidoreductase activity|activation of protein kinase B activity|positive regulation of peptidyl-serine phosphorylation|protein homodimerization activity|positive regulation of DNA binding|cell redox homeostasis|negative regulation of protein export from nucleus|protein-disulfide reductase activity|positive regulation of protein kinase B signaling|oxidation-reduction process|extracellular exosome|response to nitric oxide|cellular oxidant detoxification|negative regulation of hydrogen peroxide-induced cell death|positive regulation of peptidyl-cysteine S-nitrosylation "hsa04621,hsa05012,hsa05132,hsa05418" NOD-like receptor signaling pathway|Parkinson disease|Salmonella infection|Fluid shear stress and atherosclerosis TXN2 1384.345501 1417.893488 1350.797515 0.952679116 -0.069937731 0.836417803 1 46.50991135 46.21767419 25828 thioredoxin 2 "GO:0000098,GO:0001666,GO:0005515,GO:0005730,GO:0005739,GO:0005759,GO:0006662,GO:0006979,GO:0008113,GO:0009725,GO:0009749,GO:0014070,GO:0015035,GO:0030425,GO:0031669,GO:0033743,GO:0042493,GO:0043025,GO:0044877,GO:0045454,GO:0048678,GO:0055114" sulfur amino acid catabolic process|response to hypoxia|protein binding|nucleolus|mitochondrion|mitochondrial matrix|glycerol ether metabolic process|response to oxidative stress|peptide-methionine (S)-S-oxide reductase activity|response to hormone|response to glucose|response to organic cyclic compound|protein disulfide oxidoreductase activity|dendrite|cellular response to nutrient levels|peptide-methionine (R)-S-oxide reductase activity|response to drug|neuronal cell body|protein-containing complex binding|cell redox homeostasis|response to axon injury|oxidation-reduction process "hsa04621,hsa05012,hsa05132,hsa05418" NOD-like receptor signaling pathway|Parkinson disease|Salmonella infection|Fluid shear stress and atherosclerosis TXNDC11 669.038584 743.9627248 594.1144432 0.798580928 -0.324489477 0.395438407 1 11.34912273 9.453598559 51061 thioredoxin domain containing 11 "GO:0005515,GO:0005789,GO:0016021" protein binding|endoplasmic reticulum membrane|integral component of membrane TXNDC12 1443.23868 1402.669148 1483.808211 1.057846188 0.081129873 0.809211912 1 50.16966387 55.35790504 51060 thioredoxin domain containing 12 "GO:0005515,GO:0005783,GO:0005788,GO:0015037,GO:0019153,GO:0055114,GO:0060548,GO:1902236" protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|peptide disulfide oxidoreductase activity|protein-disulfide reductase (glutathione) activity|oxidation-reduction process|negative regulation of cell death|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway hsa00480 Glutathione metabolism TXNDC15 1028.609869 1178.363879 878.8558596 0.745827223 -0.423086638 0.227757997 1 16.16905269 12.57878624 79770 thioredoxin domain containing 15 "GO:0005515,GO:0005929,GO:0016021,GO:0045880,GO:0060170,GO:0060271" protein binding|cilium|integral component of membrane|positive regulation of smoothened signaling pathway|ciliary membrane|cilium assembly TXNDC16 215.3827116 209.0809295 221.6844937 1.060280793 0.084446383 0.880823678 1 2.244903855 2.482759028 57544 thioredoxin domain containing 16 "GO:0005515,GO:0005788,GO:0008150,GO:0070062" protein binding|endoplasmic reticulum lumen|biological_process|extracellular exosome TXNDC17 563.3062517 689.1551025 437.4574009 0.634773506 -0.655686179 0.098859423 1 18.20723774 12.05532117 84817 thioredoxin domain containing 17 "GO:0004601,GO:0005515,GO:0005829,GO:0033209,GO:0047134,GO:0055114,GO:0070062,GO:0098869" peroxidase activity|protein binding|cytosol|tumor necrosis factor-mediated signaling pathway|protein-disulfide reductase activity|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification TXNDC5 5142.975118 5886.744617 4399.20562 0.747307027 -0.420227006 0.191642587 1 93.08237516 72.55752371 81567 thioredoxin domain containing 5 "GO:0003756,GO:0005515,GO:0005576,GO:0005783,GO:0005788,GO:0018215,GO:0035578,GO:0043066,GO:0043202,GO:0043277,GO:0043312,GO:0070062" protein disulfide isomerase activity|protein binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|protein phosphopantetheinylation|azurophil granule lumen|negative regulation of apoptotic process|lysosomal lumen|apoptotic cell clearance|neutrophil degranulation|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum TXNDC9 511.9079608 509.5078961 514.3080254 1.009421109 0.013528161 0.978796686 1 12.22975237 12.87674145 10190 thioredoxin domain containing 9 "GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0008150,GO:0030496,GO:0045296" protein binding|nucleus|centrosome|cytosol|biological_process|midbody|cadherin binding TXNIP 1868.235777 1527.508732 2208.962822 1.44612124 0.53218851 0.100858443 1 24.38163522 36.77760669 10628 thioredoxin interacting protein "GO:0000122,GO:0004857,GO:0005515,GO:0005634,GO:0005737,GO:0005758,GO:0005829,GO:0006606,GO:0007049,GO:0009612,GO:0009749,GO:0015031,GO:0030216,GO:0031625,GO:0032355,GO:0032570,GO:0042127,GO:0042493,GO:0042542,GO:0043065,GO:0043086,GO:0048008,GO:0051592,GO:0051782,GO:0071228" negative regulation of transcription by RNA polymerase II|enzyme inhibitor activity|protein binding|nucleus|cytoplasm|mitochondrial intermembrane space|cytosol|protein import into nucleus|cell cycle|response to mechanical stimulus|response to glucose|protein transport|keratinocyte differentiation|ubiquitin protein ligase binding|response to estradiol|response to progesterone|regulation of cell population proliferation|response to drug|response to hydrogen peroxide|positive regulation of apoptotic process|negative regulation of catalytic activity|platelet-derived growth factor receptor signaling pathway|response to calcium ion|negative regulation of cell division|cellular response to tumor cell hsa04621 NOD-like receptor signaling pathway TXNL1 1256.409585 1428.043048 1084.776123 0.759624246 -0.396642141 0.243044041 1 9.397783592 7.446294145 9352 thioredoxin like 1 "GO:0000502,GO:0005634,GO:0005737,GO:0005829,GO:0015036,GO:0055114" proteasome complex|nucleus|cytoplasm|cytosol|disulfide oxidoreductase activity|oxidation-reduction process TXNL4A 1371.051113 1519.389085 1222.713141 0.80473998 -0.313405387 0.350326071 1 20.4441278 17.16090134 10907 thioredoxin like 4A "GO:0000245,GO:0000375,GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005829,GO:0007049,GO:0031965,GO:0046540,GO:0051301,GO:0071005" "spliceosomal complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|cytosol|cell cycle|nuclear membrane|U4/U6 x U5 tri-snRNP complex|cell division|U2-type precatalytic spliceosome" hsa03040 Spliceosome TXNL4B 251.2976039 239.5296085 263.0655992 1.098259212 0.135218601 0.79324994 1 3.891988984 4.458537122 54957 thioredoxin like 4B "GO:0000398,GO:0005515,GO:0005654,GO:0005681,GO:0005682,GO:0005829,GO:0007049,GO:0046540" "mRNA splicing, via spliceosome|protein binding|nucleoplasm|spliceosomal complex|U5 snRNP|cytosol|cell cycle|U4/U6 x U5 tri-snRNP complex" TXNRD1 14255.69141 9490.85326 19020.52956 2.004090574 1.002947712 0.004337745 0.243721434 122.0615124 255.1596643 7296 thioredoxin reductase 1 "GO:0001650,GO:0001707,GO:0001887,GO:0004791,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0007165,GO:0008283,GO:0015035,GO:0015949,GO:0019216,GO:0034599,GO:0045454,GO:0050660,GO:0055114,GO:0070062,GO:0098869" fibrillar center|mesoderm formation|selenium compound metabolic process|thioredoxin-disulfide reductase activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|signal transduction|cell population proliferation|protein disulfide oxidoreductase activity|nucleobase-containing small molecule interconversion|regulation of lipid metabolic process|cellular response to oxidative stress|cell redox homeostasis|flavin adenine dinucleotide binding|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification "hsa00450,hsa05200,hsa05225" Selenocompound metabolism|Pathways in cancer|Hepatocellular carcinoma TXNRD2 1149.082074 1163.13954 1135.024608 0.97582841 -0.035300609 0.920883856 1 15.8314739 16.11427374 10587 thioredoxin reductase 2 "GO:0000305,GO:0004791,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0034599,GO:0043231,GO:0045454,GO:0050660,GO:0055114,GO:0098869" response to oxygen radical|thioredoxin-disulfide reductase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|cellular response to oxidative stress|intracellular membrane-bounded organelle|cell redox homeostasis|flavin adenine dinucleotide binding|oxidation-reduction process|cellular oxidant detoxification "hsa00450,hsa05200,hsa05225" Selenocompound metabolism|Pathways in cancer|Hepatocellular carcinoma TXNRD3 124.4617587 122.8096722 126.1138453 1.026904828 0.038302481 0.9654757 1 2.129365508 2.280847982 114112 thioredoxin reductase 3 "GO:0004791,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0007275,GO:0007283,GO:0015035,GO:0030154,GO:0045454,GO:0050660,GO:0055114,GO:0098869" thioredoxin-disulfide reductase activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|multicellular organism development|spermatogenesis|protein disulfide oxidoreductase activity|cell differentiation|cell redox homeostasis|flavin adenine dinucleotide binding|oxidation-reduction process|cellular oxidant detoxification "hsa00450,hsa05200,hsa05225" Selenocompound metabolism|Pathways in cancer|Hepatocellular carcinoma TYK2 1446.291713 1308.278243 1584.305182 1.210984888 0.276180862 0.407249759 1 13.10256628 16.55049619 7297 tyrosine kinase 2 "GO:0004713,GO:0004715,GO:0005131,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0016020,GO:0018108,GO:0019221,GO:0031702,GO:0035556,GO:0035722,GO:0038155,GO:0060337,GO:0070062,GO:0070106" protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|growth hormone receptor binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|membrane|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|type 1 angiotensin receptor binding|intracellular signal transduction|interleukin-12-mediated signaling pathway|interleukin-23-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|interleukin-27-mediated signaling pathway "hsa04217,hsa04380,hsa04621,hsa04630,hsa04658,hsa04659,hsa05145,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171" Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 TYMP 213.2610034 232.4249168 194.0970901 0.835095879 -0.25998625 0.626640924 1 6.650566151 5.793098164 1890 thymidine phosphorylase "GO:0000002,GO:0001525,GO:0004645,GO:0005515,GO:0005829,GO:0006206,GO:0006213,GO:0006935,GO:0007165,GO:0008083,GO:0009032,GO:0016154,GO:0030154,GO:0031641,GO:0042803,GO:0043097,GO:0046074,GO:0046135,GO:0051969,GO:1905333" "mitochondrial genome maintenance|angiogenesis|1,4-alpha-oligoglucan phosphorylase activity|protein binding|cytosol|pyrimidine nucleobase metabolic process|pyrimidine nucleoside metabolic process|chemotaxis|signal transduction|growth factor activity|thymidine phosphorylase activity|pyrimidine-nucleoside phosphorylase activity|cell differentiation|regulation of myelination|protein homodimerization activity|pyrimidine nucleoside salvage|dTMP catabolic process|pyrimidine nucleoside catabolic process|regulation of transmission of nerve impulse|regulation of gastric motility" "hsa00240,hsa00983,hsa05219" Pyrimidine metabolism|Drug metabolism - other enzymes|Bladder cancer TYMS 3977.603269 3475.209236 4479.997302 1.289130236 0.366398021 0.250514933 1 102.3297023 137.5987331 7298 thymidylate synthetase "GO:0000083,GO:0000900,GO:0004799,GO:0005542,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006231,GO:0006235,GO:0007568,GO:0007623,GO:0008144,GO:0009636,GO:0015949,GO:0017148,GO:0019048,GO:0019860,GO:0032259,GO:0032570,GO:0033189,GO:0034097,GO:0035999,GO:0042493,GO:0042803,GO:0045471,GO:0046683,GO:0048589,GO:0051216,GO:0051384,GO:0051593,GO:0060574,GO:0071897,GO:0097421,GO:1990825" "regulation of transcription involved in G1/S transition of mitotic cell cycle|translation repressor activity, mRNA regulatory element binding|thymidylate synthase activity|folic acid binding|nucleus|nucleolus|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|dTMP biosynthetic process|dTTP biosynthetic process|aging|circadian rhythm|drug binding|response to toxic substance|nucleobase-containing small molecule interconversion|negative regulation of translation|modulation by virus of host process|uracil metabolic process|methylation|response to progesterone|response to vitamin A|response to cytokine|tetrahydrofolate interconversion|response to drug|protein homodimerization activity|response to ethanol|response to organophosphorus|developmental growth|cartilage development|response to glucocorticoid|response to folic acid|intestinal epithelial cell maturation|DNA biosynthetic process|liver regeneration|sequence-specific mRNA binding" "hsa00240,hsa00670,hsa01523" Pyrimidine metabolism|One carbon pool by folate|Antifolate resistance TYRO3 592.6699514 507.4779842 677.8619186 1.335746455 0.417646189 0.287061937 1 2.465416751 3.435028166 7301 TYRO3 protein tyrosine kinase "GO:0001618,GO:0001779,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005634,GO:0005635,GO:0005789,GO:0005887,GO:0006909,GO:0007155,GO:0007165,GO:0007169,GO:0007218,GO:0007275,GO:0007283,GO:0007399,GO:0009986,GO:0014065,GO:0016477,GO:0018108,GO:0021885,GO:0030168,GO:0032940,GO:0033674,GO:0034122,GO:0034446,GO:0042698,GO:0043235,GO:0043277,GO:0043491,GO:0043524,GO:0043548,GO:0045824,GO:0046718,GO:0046777,GO:0050728,GO:0051250,GO:0060068,GO:0070050,GO:0070527,GO:1903902" virus receptor activity|natural killer cell differentiation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nuclear envelope|endoplasmic reticulum membrane|integral component of plasma membrane|phagocytosis|cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|neuropeptide signaling pathway|multicellular organism development|spermatogenesis|nervous system development|cell surface|phosphatidylinositol 3-kinase signaling|cell migration|peptidyl-tyrosine phosphorylation|forebrain cell migration|platelet activation|secretion by cell|positive regulation of kinase activity|negative regulation of toll-like receptor signaling pathway|substrate adhesion-dependent cell spreading|ovulation cycle|receptor complex|apoptotic cell clearance|protein kinase B signaling|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|negative regulation of innate immune response|viral entry into host cell|protein autophosphorylation|negative regulation of inflammatory response|negative regulation of lymphocyte activation|vagina development|neuron cellular homeostasis|platelet aggregation|positive regulation of viral life cycle TYSND1 974.8699052 973.3427737 976.3970368 1.003137911 0.004519961 0.993113289 1 13.11771627 13.72570962 219743 trypsin like peroxisomal matrix peptidase 1 "GO:0002020,GO:0004252,GO:0005777,GO:0005782,GO:0005829,GO:0006508,GO:0006625,GO:0016020,GO:0016485,GO:0031998" protease binding|serine-type endopeptidase activity|peroxisome|peroxisomal matrix|cytosol|proteolysis|protein targeting to peroxisome|membrane|protein processing|regulation of fatty acid beta-oxidation TYW1 287.6281779 298.3970547 276.859301 0.927821829 -0.108080306 0.82768789 1 2.241583824 2.169379339 55253 tRNA-yW synthesizing protein 1 homolog "GO:0010181,GO:0031591,GO:0046872,GO:0051539,GO:0055114,GO:0102521" "FMN binding|wybutosine biosynthetic process|metal ion binding|4 iron, 4 sulfur cluster binding|oxidation-reduction process|tRNA-4-demethylwyosine synthase activity" TYW1B 15.04619021 18.26920743 11.823173 0.64716398 -0.627796782 0.633597307 1 0.296846617 0.200383691 441250 tRNA-yW synthesizing protein 1 homolog B "GO:0005515,GO:0010181,GO:0031591,GO:0046872,GO:0051539,GO:0055114,GO:0102521" "protein binding|FMN binding|wybutosine biosynthetic process|metal ion binding|4 iron, 4 sulfur cluster binding|oxidation-reduction process|tRNA-4-demethylwyosine synthase activity" TYW3 145.9270134 142.0938356 149.7601913 1.053952768 0.075810215 0.910516917 1 5.518827833 6.067138714 127253 tRNA-yW synthesizing protein 3 homolog "GO:0005515,GO:0005737,GO:0008175,GO:0030488" protein binding|cytoplasm|tRNA methyltransferase activity|tRNA methylation TYW5 263.8360957 254.7539481 272.9182434 1.07130133 0.099364331 0.846942894 1 2.45806606 2.746762592 129450 tRNA-yW synthesizing protein 5 "GO:0000049,GO:0005506,GO:0005737,GO:0006400,GO:0016706,GO:0031591,GO:0042803,GO:0055114,GO:0102524" tRNA binding|iron ion binding|cytoplasm|tRNA modification|2-oxoglutarate-dependent dioxygenase activity|wybutosine biosynthetic process|protein homodimerization activity|oxidation-reduction process|tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity U2AF1 171.0863908 77.1366536 265.0361281 3.435929817 1.780700568 0.002236121 0.152172743 3.513218869 12.59115066 7307 U2 small nuclear RNA auxiliary factor 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005681,GO:0006397,GO:0006405,GO:0006406,GO:0008380,GO:0015030,GO:0016607,GO:0030628,GO:0031124,GO:0046872,GO:0071013,GO:0089701" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|spliceosomal complex|mRNA processing|RNA export from nucleus|mRNA export from nucleus|RNA splicing|Cajal body|nuclear speck|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|metal ion binding|catalytic step 2 spliceosome|U2AF complex" "hsa03040,hsa05131" Spliceosome|Shigellosis U2AF1L4 63.48472856 62.92727004 64.04218708 1.01771755 0.025337221 0.997280468 1 3.849087238 4.086024325 199746 U2 small nuclear RNA auxiliary factor 1 like 4 "GO:0000398,GO:0005654,GO:0005681,GO:0005737,GO:0006405,GO:0006406,GO:0016607,GO:0030628,GO:0031124,GO:0046872,GO:0089701" "mRNA splicing, via spliceosome|nucleoplasm|spliceosomal complex|cytoplasm|RNA export from nucleus|mRNA export from nucleus|nuclear speck|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|metal ion binding|U2AF complex" "hsa03040,hsa05131" Spliceosome|Shigellosis U2AF1L5 106.0562177 110.6302006 101.4822349 0.917310413 -0.124518079 0.864311287 1 4.813599122 4.605769211 102724594 U2 small nuclear RNA auxiliary factor 1 like 5 "GO:0000398,GO:0005515,GO:0005654,GO:0005681,GO:0016607,GO:0030628,GO:0046872,GO:0089701" "mRNA splicing, via spliceosome|protein binding|nucleoplasm|spliceosomal complex|nuclear speck|pre-mRNA 3'-splice site binding|metal ion binding|U2AF complex" "hsa03040,hsa05131" Spliceosome|Shigellosis U2AF2 3442.846182 3626.437675 3259.25469 0.898748298 -0.154010961 0.62858199 1 57.0924075 53.52200421 11338 U2 small nuclear RNA auxiliary factor 2 "GO:0000243,GO:0000398,GO:0000974,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006397,GO:0006405,GO:0006406,GO:0008187,GO:0016607,GO:0019899,GO:0030628,GO:0031124,GO:0031397,GO:0033120,GO:0048025,GO:0070742,GO:0071004,GO:0089701" "commitment complex|mRNA splicing, via spliceosome|Prp19 complex|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|mRNA processing|RNA export from nucleus|mRNA export from nucleus|poly-pyrimidine tract binding|nuclear speck|enzyme binding|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|negative regulation of protein ubiquitination|positive regulation of RNA splicing|negative regulation of mRNA splicing, via spliceosome|C2H2 zinc finger domain binding|U2-type prespliceosome|U2AF complex" hsa03040 Spliceosome U2SURP 2155.773397 2021.792289 2289.754504 1.132536966 0.17955814 0.57607043 1 14.741815 17.41483134 23350 U2 snRNP associated SURP domain containing "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm" hsa03040 Spliceosome UACA 3178.489247 3167.677577 3189.300916 1.006826244 0.009814727 0.976470124 1 20.51031634 21.539857 55075 uveal autoantigen with coiled-coil domains and ankyrin repeats "GO:0003674,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005856,GO:0008150,GO:0043280,GO:0070062,GO:0097190,GO:1901223" molecular_function|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|cytoskeleton|biological_process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|extracellular exosome|apoptotic signaling pathway|negative regulation of NIK/NF-kappaB signaling UAP1 2250.233333 1912.177044 2588.289622 1.353582624 0.436782954 0.172695254 1 37.26241691 52.61041422 6675 UDP-N-acetylglucosamine pyrophosphorylase 1 "GO:0003977,GO:0005654,GO:0005829,GO:0005886,GO:0006048,GO:0030246,GO:0042802,GO:0052630" UDP-N-acetylglucosamine diphosphorylase activity|nucleoplasm|cytosol|plasma membrane|UDP-N-acetylglucosamine biosynthetic process|carbohydrate binding|identical protein binding|UDP-N-acetylgalactosamine diphosphorylase activity hsa00520 Amino sugar and nucleotide sugar metabolism UAP1L1 611.177929 728.7383853 493.6174727 0.677358957 -0.562007522 0.149066368 1 9.252451336 6.537197673 91373 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 "GO:0003977,GO:0006048" UDP-N-acetylglucosamine diphosphorylase activity|UDP-N-acetylglucosamine biosynthetic process hsa00520 Amino sugar and nucleotide sugar metabolism UBA1 15369.784 15401.95682 15337.61117 0.995822242 -0.006039856 0.986489656 1 98.35516052 102.1632978 7317 ubiquitin like modifier activating enzyme 1 "GO:0000792,GO:0003723,GO:0004839,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005765,GO:0005829,GO:0006511,GO:0006974,GO:0010008,GO:0016567,GO:0018215,GO:0030057,GO:0030867,GO:0032446,GO:0070062" heterochromatin|RNA binding|ubiquitin activating enzyme activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|lysosomal membrane|cytosol|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|endosome membrane|protein ubiquitination|protein phosphopantetheinylation|desmosome|rough endoplasmic reticulum membrane|protein modification by small protein conjugation|extracellular exosome "hsa04120,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBA2 2228.384564 2203.469407 2253.299721 1.022614479 0.032262359 0.921135765 1 37.90691308 40.4339609 10054 ubiquitin like modifier activating enzyme 2 "GO:0000287,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0008134,GO:0016740,GO:0016925,GO:0018215,GO:0019948,GO:0031510,GO:0032183,GO:0032446,GO:0033235,GO:0044388,GO:0044390,GO:0046982" magnesium ion binding|protein binding|ATP binding|nucleoplasm|cytoplasm|transcription factor binding|transferase activity|protein sumoylation|protein phosphopantetheinylation|SUMO activating enzyme activity|SUMO activating enzyme complex|SUMO binding|protein modification by small protein conjugation|positive regulation of protein sumoylation|small protein activating enzyme binding|ubiquitin-like protein conjugating enzyme binding|protein heterodimerization activity hsa04120 Ubiquitin mediated proteolysis UBA3 1247.222525 1136.750685 1357.694366 1.194364239 0.256242875 0.451532982 1 27.27257791 33.97652136 9039 ubiquitin like modifier activating enzyme 3 "GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0007113,GO:0016922,GO:0018215,GO:0019781,GO:0019788,GO:0032446,GO:0032991,GO:0042802,GO:0043687,GO:0044877,GO:0045116,GO:0045892,GO:0046982,GO:0051726" "protein binding|ATP binding|nucleus|cytoplasm|cytosol|cellular protein modification process|proteolysis|endomitotic cell cycle|nuclear receptor binding|protein phosphopantetheinylation|NEDD8 activating enzyme activity|NEDD8 transferase activity|protein modification by small protein conjugation|protein-containing complex|identical protein binding|post-translational protein modification|protein-containing complex binding|protein neddylation|negative regulation of transcription, DNA-templated|protein heterodimerization activity|regulation of cell cycle" hsa04120 Ubiquitin mediated proteolysis UBA5 507.5282108 580.5548139 434.5016077 0.748424778 -0.418070772 0.30472111 1 5.100269428 3.981596131 79876 ubiquitin like modifier activating enzyme 5 "GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005789,GO:0005794,GO:0005829,GO:0008270,GO:0018215,GO:0030218,GO:0030219,GO:0032446,GO:0033146,GO:0034976,GO:0042803,GO:0043231,GO:0050905,GO:0061709,GO:0071566,GO:0071569,GO:1990592" protein binding|ATP binding|nucleus|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|zinc ion binding|protein phosphopantetheinylation|erythrocyte differentiation|megakaryocyte differentiation|protein modification by small protein conjugation|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|protein homodimerization activity|intracellular membrane-bounded organelle|neuromuscular process|reticulophagy|UFM1 activating enzyme activity|protein ufmylation|protein K69-linked ufmylation UBA52 9112.91104 9107.199904 9118.622175 1.001254202 0.001808298 0.996053437 1 116.5944254 121.7693725 7311 ubiquitin A-52 residue ribosomal protein fusion product 1 "GO:0000122,GO:0000184,GO:0000187,GO:0000209,GO:0000715,GO:0000717,GO:0002755,GO:0002756,GO:0003735,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005741,GO:0005765,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0006283,GO:0006294,GO:0006296,GO:0006297,GO:0006413,GO:0006464,GO:0006614,GO:0006625,GO:0007179,GO:0007249,GO:0007254,GO:0010008,GO:0016055,GO:0016197,GO:0016567,GO:0016579,GO:0019058,GO:0019068,GO:0019083,GO:0019221,GO:0019941,GO:0019985,GO:0022627,GO:0030512,GO:0030666,GO:0031145,GO:0031386,GO:0031625,GO:0031982,GO:0033683,GO:0035666,GO:0036297,GO:0042276,GO:0042769,GO:0043065,GO:0043066,GO:0043488,GO:0043657,GO:0044267,GO:0045944,GO:0051092,GO:0051403,GO:0055085,GO:0061024,GO:0061418,GO:0070062,GO:0070423,GO:0070498,GO:0070911,GO:0070987,GO:0075733" "negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|activation of MAPK activity|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|structural constituent of ribosome|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrial outer membrane|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|translational initiation|cellular protein modification process|SRP-dependent cotranslational protein targeting to membrane|protein targeting to peroxisome|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|Wnt signaling pathway|endosomal transport|protein ubiquitination|protein deubiquitination|viral life cycle|virion assembly|viral transcription|cytokine-mediated signaling pathway|modification-dependent protein catabolic process|translesion synthesis|cytosolic small ribosomal subunit|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|anaphase-promoting complex-dependent catabolic process|protein tag|ubiquitin protein ligase binding|vesicle|nucleotide-excision repair, DNA incision|TRIF-dependent toll-like receptor signaling pathway|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of mRNA stability|host cell|cellular protein metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|transmembrane transport|membrane organization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|error-free translesion synthesis|intracellular transport of virus" "hsa03010,hsa04120,hsa04137,hsa05012,hsa05022,hsa05131,hsa05167,hsa05171" Ribosome|Ubiquitin mediated proteolysis|Mitophagy - animal|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection|Coronavirus disease - COVID-19 UBA6 2308.86869 1946.685547 2671.051833 1.37210236 0.456388112 0.153848621 1 10.33467039 14.79105223 55236 ubiquitin like modifier activating enzyme 6 "GO:0004839,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006511,GO:0006974,GO:0007612,GO:0007626,GO:0016567,GO:0018215,GO:0019780,GO:0021764,GO:0021766,GO:0032446,GO:0060996" ubiquitin activating enzyme activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|learning|locomotory behavior|protein ubiquitination|protein phosphopantetheinylation|FAT10 activating enzyme activity|amygdala development|hippocampus development|protein modification by small protein conjugation|dendritic spine development hsa04120 Ubiquitin mediated proteolysis UBA7 591.9397868 491.2386887 692.6408848 1.409988465 0.495683361 0.206495851 1 7.159570244 10.52975931 7318 ubiquitin like modifier activating enzyme 7 "GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006974,GO:0016567,GO:0018215,GO:0019782,GO:0019941,GO:0032020,GO:0032446,GO:0032480" ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|cellular response to DNA damage stimulus|protein ubiquitination|protein phosphopantetheinylation|ISG15 activating enzyme activity|modification-dependent protein catabolic process|ISG15-protein conjugation|protein modification by small protein conjugation|negative regulation of type I interferon production "hsa04120,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBAC1 733.5694439 608.973581 858.1653068 1.409199567 0.494875937 0.18592961 1 16.58191589 24.37379413 10422 UBA domain containing 1 "GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0016567,GO:0070062" protein binding|Golgi apparatus|cytosol|plasma membrane|protein ubiquitination|extracellular exosome UBAC2 1081.760208 1107.316961 1056.203455 0.95384022 -0.068180477 0.846838528 1 8.511412615 8.468240931 337867 UBA domain containing 2 "GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0016055,GO:0070972,GO:0090090,GO:1904153" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|Wnt signaling pathway|protein localization to endoplasmic reticulum|negative regulation of canonical Wnt signaling pathway|negative regulation of retrograde protein transport, ER to cytosol" UBALD1 326.8700078 354.219633 299.5203826 0.845578152 -0.241989994 0.602080839 1 13.05675022 11.5160828 124402 UBA like domain containing 1 GO:0005515 protein binding UBALD2 784.2214867 602.8838452 965.5591282 1.601567426 0.679484537 0.065965066 1 21.11614102 35.27570569 283991 UBA like domain containing 2 UBAP1 1648.6433 1502.134833 1795.151767 1.195066999 0.257091502 0.43327847 1 20.12641008 25.0884887 51271 ubiquitin associated protein 1 "GO:0000813,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0010008,GO:0015031,GO:0016197,GO:0019058,GO:0043130,GO:0043162,GO:0043231,GO:0043657,GO:0075733" ESCRT I complex|protein binding|cytoplasm|cytosol|plasma membrane|endosome membrane|protein transport|endosomal transport|viral life cycle|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|intracellular transport of virus UBAP1L 27.51045318 28.41876711 26.60213925 0.936076472 -0.095301701 0.964026605 1 0.083685697 0.081710618 390595 ubiquitin associated protein 1 like "GO:0000813,GO:0043130,GO:0043162" ESCRT I complex|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway UBAP2 2127.224977 2090.809295 2163.640659 1.034834054 0.049399436 0.879009524 1 22.35425688 24.12941978 55833 ubiquitin associated protein 2 "GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0010629,GO:0043065,GO:0045296,GO:0045893,GO:0045926,GO:0046426" "P-body|RNA binding|protein binding|nucleus|cytoplasm|negative regulation of gene expression|positive regulation of apoptotic process|cadherin binding|positive regulation of transcription, DNA-templated|negative regulation of growth|negative regulation of receptor signaling pathway via JAK-STAT" UBAP2L 4152.574801 4424.193066 3880.956537 0.877212291 -0.189002068 0.553683641 1 41.31079852 37.79934096 9898 ubiquitin associated protein 2 like "GO:0003723,GO:0005515,GO:0005634,GO:0005671,GO:0005737,GO:0007339,GO:0010494,GO:0031519,GO:0034063,GO:0061484" RNA binding|protein binding|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|binding of sperm to zona pellucida|cytoplasmic stress granule|PcG protein complex|stress granule assembly|hematopoietic stem cell homeostasis UBASH3B 927.2830193 919.5501073 935.0159313 1.016818903 0.024062756 0.94948173 1 4.833122557 5.126103244 84959 ubiquitin associated and SH3 domain containing B "GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0006469,GO:0009968,GO:0031625,GO:0035335,GO:0038063,GO:0042802,GO:0043393,GO:0045670,GO:0045671,GO:0045779,GO:0051219,GO:0051279,GO:0070527,GO:0090331" protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|negative regulation of protein kinase activity|negative regulation of signal transduction|ubiquitin protein ligase binding|peptidyl-tyrosine dephosphorylation|collagen-activated tyrosine kinase receptor signaling pathway|identical protein binding|regulation of protein binding|regulation of osteoclast differentiation|negative regulation of osteoclast differentiation|negative regulation of bone resorption|phosphoprotein binding|regulation of release of sequestered calcium ion into cytosol|platelet aggregation|negative regulation of platelet aggregation UBB 17196.05771 17832.77636 16559.33905 0.92859007 -0.106886242 0.764242561 1 595.3640162 576.663611 7314 ubiquitin B "GO:0000122,GO:0000187,GO:0000209,GO:0000715,GO:0000717,GO:0002755,GO:0002756,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005789,GO:0005829,GO:0005886,GO:0006283,GO:0006294,GO:0006296,GO:0006297,GO:0006625,GO:0007141,GO:0007144,GO:0007179,GO:0007249,GO:0007254,GO:0008585,GO:0010008,GO:0016055,GO:0016197,GO:0016567,GO:0016579,GO:0019058,GO:0019068,GO:0019221,GO:0019941,GO:0019985,GO:0021888,GO:0030512,GO:0030666,GO:0031145,GO:0031386,GO:0031398,GO:0031625,GO:0031982,GO:0033683,GO:0035666,GO:0036297,GO:0042276,GO:0042769,GO:0043005,GO:0043025,GO:0043065,GO:0043066,GO:0043488,GO:0043657,GO:0044267,GO:0045944,GO:0047497,GO:0048812,GO:0051092,GO:0051403,GO:0051881,GO:0055085,GO:0060613,GO:0061024,GO:0061136,GO:0061418,GO:0070062,GO:0070423,GO:0070498,GO:0070911,GO:0070987,GO:0072520,GO:0075733,GO:0097009,GO:1901214,GO:1902255,GO:1902527" "negative regulation of transcription by RNA polymerase II|activation of MAPK activity|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|protein targeting to peroxisome|male meiosis I|female meiosis I|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|female gonad development|endosome membrane|Wnt signaling pathway|endosomal transport|protein ubiquitination|protein deubiquitination|viral life cycle|virion assembly|cytokine-mediated signaling pathway|modification-dependent protein catabolic process|translesion synthesis|hypothalamus gonadotrophin-releasing hormone neuron development|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|anaphase-promoting complex-dependent catabolic process|protein tag|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|vesicle|nucleotide-excision repair, DNA incision|TRIF-dependent toll-like receptor signaling pathway|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|neuron projection|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of mRNA stability|host cell|cellular protein metabolic process|positive regulation of transcription by RNA polymerase II|mitochondrion transport along microtubule|neuron projection morphogenesis|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|regulation of mitochondrial membrane potential|transmembrane transport|fat pad development|membrane organization|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|error-free translesion synthesis|seminiferous tubule development|intracellular transport of virus|energy homeostasis|regulation of neuron death|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of protein monoubiquitination" "hsa04120,hsa04137,hsa05012,hsa05022,hsa05131,hsa05167" Ubiquitin mediated proteolysis|Mitophagy - animal|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection UBC 21165.99858 21727.16241 20604.83474 0.948344489 -0.076516877 0.834794759 1 501.7802679 496.3586945 7316 ubiquitin C "GO:0000122,GO:0000187,GO:0000209,GO:0000715,GO:0000717,GO:0002020,GO:0002755,GO:0002756,GO:0003723,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005741,GO:0005789,GO:0005829,GO:0005886,GO:0006283,GO:0006294,GO:0006296,GO:0006297,GO:0006625,GO:0007179,GO:0007249,GO:0007254,GO:0010008,GO:0016055,GO:0016197,GO:0016567,GO:0016579,GO:0019058,GO:0019068,GO:0019221,GO:0019941,GO:0019985,GO:0030512,GO:0030666,GO:0031145,GO:0031386,GO:0031625,GO:0031982,GO:0033683,GO:0035666,GO:0036297,GO:0042276,GO:0042769,GO:0043065,GO:0043066,GO:0043488,GO:0043657,GO:0044267,GO:0045944,GO:0051092,GO:0051403,GO:0055085,GO:0061024,GO:0061418,GO:0070062,GO:0070423,GO:0070498,GO:0070911,GO:0070987,GO:0075733" "negative regulation of transcription by RNA polymerase II|activation of MAPK activity|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|protease binding|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|RNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|protein targeting to peroxisome|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|Wnt signaling pathway|endosomal transport|protein ubiquitination|protein deubiquitination|viral life cycle|virion assembly|cytokine-mediated signaling pathway|modification-dependent protein catabolic process|translesion synthesis|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|anaphase-promoting complex-dependent catabolic process|protein tag|ubiquitin protein ligase binding|vesicle|nucleotide-excision repair, DNA incision|TRIF-dependent toll-like receptor signaling pathway|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of mRNA stability|host cell|cellular protein metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|transmembrane transport|membrane organization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|error-free translesion synthesis|intracellular transport of virus" "hsa03320,hsa04120,hsa04137,hsa05012,hsa05022,hsa05131,hsa05167" PPAR signaling pathway|Ubiquitin mediated proteolysis|Mitophagy - animal|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection UBE2A 1855.389483 1625.959461 2084.819505 1.282208785 0.358631198 0.268710629 1 46.3677425 62.01412635 7319 ubiquitin conjugating enzyme E2 A "GO:0000209,GO:0000785,GO:0001741,GO:0001835,GO:0004842,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006281,GO:0006301,GO:0006511,GO:0008284,GO:0009411,GO:0016567,GO:0016574,GO:0031625,GO:0033503,GO:0033522,GO:0043161,GO:0051865,GO:0060135,GO:0061631,GO:0070936,GO:0070979" protein polyubiquitination|chromatin|XY body|blastocyst hatching|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleoplasm|cytosol|DNA repair|postreplication repair|ubiquitin-dependent protein catabolic process|positive regulation of cell population proliferation|response to UV|protein ubiquitination|histone ubiquitination|ubiquitin protein ligase binding|HULC complex|histone H2A ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|protein autoubiquitination|maternal process involved in female pregnancy|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|protein K11-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2B 775.8534201 704.3794421 847.3273982 1.202941693 0.266566716 0.471596344 1 15.91893522 19.97443587 7320 ubiquitin conjugating enzyme E2 B "GO:0000209,GO:0000785,GO:0001701,GO:0001741,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005886,GO:0006281,GO:0006301,GO:0006511,GO:0006513,GO:0006974,GO:0007283,GO:0007288,GO:0009411,GO:0010845,GO:0016567,GO:0016574,GO:0031625,GO:0033128,GO:0033503,GO:0033522,GO:0042493,GO:0042769,GO:0043066,GO:0043161,GO:0043951,GO:0045141,GO:0050821,GO:0051026,GO:0051865,GO:0061631,GO:0070076,GO:0070193,GO:0070534,GO:0070829,GO:0070936,GO:0070979,GO:0090263" "protein polyubiquitination|chromatin|in utero embryonic development|XY body|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|cytoplasm|plasma membrane|DNA repair|postreplication repair|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|spermatogenesis|sperm axoneme assembly|response to UV|positive regulation of reciprocal meiotic recombination|protein ubiquitination|histone ubiquitination|ubiquitin protein ligase binding|negative regulation of histone phosphorylation|HULC complex|histone H2A ubiquitination|response to drug|DNA damage response, detection of DNA damage|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of cAMP-mediated signaling|meiotic telomere clustering|protein stabilization|chiasma assembly|protein autoubiquitination|ubiquitin conjugating enzyme activity|histone lysine demethylation|synaptonemal complex organization|protein K63-linked ubiquitination|heterochromatin maintenance|protein K48-linked ubiquitination|protein K11-linked ubiquitination|positive regulation of canonical Wnt signaling pathway" hsa04120 Ubiquitin mediated proteolysis UBE2C 5522.46819 5493.956657 5550.979723 1.010379235 0.014896894 0.96378111 1 227.3280418 239.5815403 11065 ubiquitin conjugating enzyme E2 C "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005680,GO:0005829,GO:0005886,GO:0006511,GO:0010458,GO:0010994,GO:0016567,GO:0030071,GO:0031145,GO:0031536,GO:0044389,GO:0051301,GO:0061631,GO:0070936,GO:0070979,GO:1901990,GO:1904668" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|anaphase-promoting complex|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|exit from mitosis|free ubiquitin chain polymerization|protein ubiquitination|regulation of mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent catabolic process|positive regulation of exit from mitosis|ubiquitin-like protein ligase binding|cell division|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition|positive regulation of ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE2D1 435.5581333 409.0272553 462.0890114 1.1297267 0.175973803 0.680907577 1 7.897745908 9.306630682 7321 ubiquitin conjugating enzyme E2 D1 "GO:0000122,GO:0000151,GO:0000209,GO:0002756,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0006625,GO:0016567,GO:0016579,GO:0030509,GO:0031145,GO:0031398,GO:0031625,GO:0032991,GO:0035666,GO:0061630,GO:0061631,GO:0070936,GO:1901990,GO:1902916" negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|protein polyubiquitination|MyD88-independent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein targeting to peroxisome|protein ubiquitination|protein deubiquitination|BMP signaling pathway|anaphase-promoting complex-dependent catabolic process|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein-containing complex|TRIF-dependent toll-like receptor signaling pathway|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|regulation of mitotic cell cycle phase transition|positive regulation of protein polyubiquitination "hsa04120,hsa04141,hsa05131" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Shigellosis UBE2D2 2138.480051 1917.251824 2359.708278 1.230776389 0.299568673 0.350689588 1 31.58817217 40.55268204 7322 ubiquitin conjugating enzyme E2 D2 "GO:0000151,GO:0000209,GO:0002756,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006464,GO:0006511,GO:0006625,GO:0016567,GO:0032991,GO:0035666,GO:0051865,GO:0061630,GO:0061631,GO:0070062,GO:0070936" ubiquitin ligase complex|protein polyubiquitination|MyD88-independent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|protein targeting to peroxisome|protein ubiquitination|protein-containing complex|TRIF-dependent toll-like receptor signaling pathway|protein autoubiquitination|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|extracellular exosome|protein K48-linked ubiquitination "hsa04120,hsa04141,hsa05131" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Shigellosis UBE2D3 3552.475281 3307.741501 3797.209061 1.147976364 0.199092938 0.531665927 1 32.15459463 38.50276467 7323 ubiquitin conjugating enzyme E2 D3 "GO:0000122,GO:0000209,GO:0002756,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006281,GO:0006464,GO:0006513,GO:0006625,GO:0006915,GO:0010008,GO:0016567,GO:0030509,GO:0035666,GO:0043161,GO:0051865,GO:0061630,GO:0061631,GO:0070062,GO:0070936,GO:0070979,GO:0071276,GO:0071288,GO:1903955" negative regulation of transcription by RNA polymerase II|protein polyubiquitination|MyD88-independent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|DNA repair|cellular protein modification process|protein monoubiquitination|protein targeting to peroxisome|apoptotic process|endosome membrane|protein ubiquitination|BMP signaling pathway|TRIF-dependent toll-like receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|protein autoubiquitination|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|extracellular exosome|protein K48-linked ubiquitination|protein K11-linked ubiquitination|cellular response to cadmium ion|cellular response to mercury ion|positive regulation of protein targeting to mitochondrion "hsa04120,hsa04141,hsa05131" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Shigellosis UBE2D4 164.2110667 179.6472064 148.7749269 0.828150517 -0.272035092 0.641492429 1 2.304000316 1.990250499 51619 ubiquitin conjugating enzyme E2 D4 (putative) "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0006511,GO:0016567,GO:0031625,GO:0035519,GO:0044314,GO:0061631,GO:0070534,GO:0070936,GO:0070979,GO:0085020" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin protein ligase binding|protein K29-linked ubiquitination|protein K27-linked ubiquitination|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination "hsa04120,hsa04141,hsa05131" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Shigellosis UBE2E1 2498.508834 2416.610161 2580.407507 1.067779797 0.094614158 0.767630922 1 63.71305536 70.96203501 7324 ubiquitin conjugating enzyme E2 E1 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0010390,GO:0016567,GO:0018215,GO:0031145,GO:0032020,GO:0033523,GO:0042296,GO:0061631,GO:0070936,GO:1901990" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|histone monoubiquitination|protein ubiquitination|protein phosphopantetheinylation|anaphase-promoting complex-dependent catabolic process|ISG15-protein conjugation|histone H2B ubiquitination|ISG15 transferase activity|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|regulation of mitotic cell cycle phase transition hsa04120 Ubiquitin mediated proteolysis UBE2E2 629.1853557 680.0204988 578.3502125 0.85048938 -0.233634873 0.547102706 1 1.591747437 1.412078966 7325 ubiquitin conjugating enzyme E2 E2 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0006974,GO:0018215,GO:0032020,GO:0042296,GO:0061631,GO:0070534,GO:0070936,GO:0070979,GO:1900087" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|cellular response to DNA damage stimulus|protein phosphopantetheinylation|ISG15-protein conjugation|ISG15 transferase activity|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|positive regulation of G1/S transition of mitotic cell cycle hsa04120 Ubiquitin mediated proteolysis UBE2E3 933.1824817 885.0416044 981.3233589 1.108787829 0.148983326 0.677839661 1 5.936984771 6.866419212 10477 ubiquitin conjugating enzyme E2 E3 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0016567,GO:0040008,GO:0061631,GO:0070534,GO:0070936,GO:0070979" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|protein ubiquitination|regulation of growth|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2F 634.6367231 648.5568638 620.7165824 0.957073492 -0.063298384 0.873490439 1 14.54055652 14.51584247 140739 ubiquitin conjugating enzyme E2 F (putative) "GO:0000209,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0018215,GO:0019788,GO:0043687,GO:0045116,GO:0061631,GO:0061654" protein polyubiquitination|protein binding|ATP binding|nucleus|cytosol|protein phosphopantetheinylation|NEDD8 transferase activity|post-translational protein modification|protein neddylation|ubiquitin conjugating enzyme activity|NEDD8 conjugating enzyme activity hsa04120 Ubiquitin mediated proteolysis UBE2G1 1646.516149 1592.465914 1700.566383 1.067882438 0.094752831 0.773923212 1 19.35511895 21.55932795 7326 ubiquitin conjugating enzyme E2 G1 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005829,GO:0006511,GO:0016567,GO:0031625,GO:0043161,GO:0044257,GO:0061631,GO:0070062,GO:0070534,GO:0070936" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process|cellular protein catabolic process|ubiquitin conjugating enzyme activity|extracellular exosome|protein K63-linked ubiquitination|protein K48-linked ubiquitination "hsa04120,hsa04141,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2G2 1970.161655 2130.392578 1809.930733 0.849576154 -0.235184821 0.466238683 1 30.33367121 26.88086371 7327 ubiquitin conjugating enzyme E2 G2 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005783,GO:0005811,GO:0005829,GO:0006511,GO:0016567,GO:0030433,GO:0035458,GO:0042802,GO:0044257,GO:0061631,GO:0070936,GO:1904153" "protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|endoplasmic reticulum|lipid droplet|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin-dependent ERAD pathway|cellular response to interferon-beta|identical protein binding|cellular protein catabolic process|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|negative regulation of retrograde protein transport, ER to cytosol" "hsa04120,hsa04141,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2H 3665.987046 3523.927122 3808.04697 1.080625915 0.111867185 0.725670864 1 34.57467591 38.97170675 7328 ubiquitin conjugating enzyme E2 H "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006511,GO:0016567,GO:0043161,GO:0061631,GO:0070936,GO:0070979" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|protein K11-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2I 2241.643818 2166.930992 2316.356643 1.068957272 0.096204188 0.764710263 1 28.18372119 31.42495105 7329 ubiquitin conjugating enzyme E2 I "GO:0000122,GO:0000795,GO:0001221,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006511,GO:0007049,GO:0007059,GO:0008134,GO:0016032,GO:0016605,GO:0016925,GO:0019789,GO:0019899,GO:0044388,GO:0045892,GO:0051301,GO:0061656,GO:0071535,GO:1903755,GO:1990234,GO:1990356" "negative regulation of transcription by RNA polymerase II|synaptonemal complex|transcription coregulator binding|RNA binding|protein binding|ATP binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|cell cycle|chromosome segregation|transcription factor binding|viral process|PML body|protein sumoylation|SUMO transferase activity|enzyme binding|small protein activating enzyme binding|negative regulation of transcription, DNA-templated|cell division|SUMO conjugating enzyme activity|RING-like zinc finger domain binding|positive regulation of SUMO transferase activity|transferase complex|sumoylated E2 ligase complex" "hsa03013,hsa04064,hsa04120,hsa05206" RNA transport|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|MicroRNAs in cancer other UBE2J1 1551.811998 1584.346267 1519.27773 0.958930357 -0.060502053 0.856287868 1 19.2703048 19.27487547 51465 ubiquitin conjugating enzyme E2 J1 "GO:0000209,GO:0005515,GO:0005524,GO:0005634,GO:0005789,GO:0007286,GO:0016021,GO:0018279,GO:0030433,GO:0031625,GO:0032680,GO:0061631,GO:1904153" "protein polyubiquitination|protein binding|ATP binding|nucleus|endoplasmic reticulum membrane|spermatid development|integral component of membrane|protein N-linked glycosylation via asparagine|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|regulation of tumor necrosis factor production|ubiquitin conjugating enzyme activity|negative regulation of retrograde protein transport, ER to cytosol" "hsa04120,hsa04141,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2J2 1457.46959 1533.598468 1381.340712 0.90071863 -0.150851592 0.651235274 1 17.92140106 16.83747774 118424 ubiquitin conjugating enzyme E2 J2 "GO:0000151,GO:0000209,GO:0005515,GO:0005524,GO:0005634,GO:0005783,GO:0005789,GO:0006986,GO:0016021,GO:0016567,GO:0030433,GO:0031625,GO:0061631,GO:1903955" ubiquitin ligase complex|protein polyubiquitination|protein binding|ATP binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|response to unfolded protein|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|ubiquitin conjugating enzyme activity|positive regulation of protein targeting to mitochondrion "hsa04120,hsa04141,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2K 1430.050933 1477.77589 1382.325976 0.93540975 -0.096329628 0.774206915 1 14.77672962 14.41770547 3093 ubiquitin conjugating enzyme E2 K "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006511,GO:0010800,GO:0010994,GO:0016567,GO:0031625,GO:0032433,GO:0032434,GO:0034450,GO:0035458,GO:0043161,GO:0060340,GO:0061631,GO:0070059,GO:0070936,GO:1903265" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|positive regulation of peptidyl-threonine phosphorylation|free ubiquitin chain polymerization|protein ubiquitination|ubiquitin protein ligase binding|filopodium tip|regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin-ubiquitin ligase activity|cellular response to interferon-beta|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of type I interferon-mediated signaling pathway|ubiquitin conjugating enzyme activity|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|protein K48-linked ubiquitination|positive regulation of tumor necrosis factor-mediated signaling pathway hsa04120 Ubiquitin mediated proteolysis UBE2L3 2790.423482 2873.340346 2707.506617 0.942285386 -0.085764026 0.788419087 1 44.20551398 43.44850421 7332 ubiquitin conjugating enzyme E2 L3 "GO:0000151,GO:0000209,GO:0003713,GO:0003723,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006464,GO:0006511,GO:0008283,GO:0016567,GO:0019899,GO:0031398,GO:0031625,GO:0044770,GO:0045893,GO:0051443,GO:0061631,GO:0070979,GO:0071383,GO:0071385,GO:0097027,GO:1903955" "ubiquitin ligase complex|protein polyubiquitination|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|cellular protein modification process|ubiquitin-dependent protein catabolic process|cell population proliferation|protein ubiquitination|enzyme binding|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|cell cycle phase transition|positive regulation of transcription, DNA-templated|positive regulation of ubiquitin-protein transferase activity|ubiquitin conjugating enzyme activity|protein K11-linked ubiquitination|cellular response to steroid hormone stimulus|cellular response to glucocorticoid stimulus|ubiquitin-protein transferase activator activity|positive regulation of protein targeting to mitochondrion" "hsa04120,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2L6 1326.375483 1462.55155 1190.199415 0.813782882 -0.297284162 0.377918772 1 56.71751643 48.14394622 9246 ubiquitin conjugating enzyme E2 L6 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006464,GO:0006511,GO:0018215,GO:0019985,GO:0031625,GO:0032020,GO:0032480,GO:0042296,GO:0043130,GO:0044267,GO:0061631" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|protein phosphopantetheinylation|translesion synthesis|ubiquitin protein ligase binding|ISG15-protein conjugation|negative regulation of type I interferon production|ISG15 transferase activity|ubiquitin binding|cellular protein metabolic process|ubiquitin conjugating enzyme activity "hsa04120,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2M 1334.203658 1391.504633 1276.902684 0.917641705 -0.123997134 0.713997145 1 60.80655799 58.20221239 9040 ubiquitin conjugating enzyme E2 M "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006464,GO:0018215,GO:0019788,GO:0043525,GO:0043687,GO:0045116,GO:0061631" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|cellular protein modification process|protein phosphopantetheinylation|NEDD8 transferase activity|positive regulation of neuron apoptotic process|post-translational protein modification|protein neddylation|ubiquitin conjugating enzyme activity hsa04120 Ubiquitin mediated proteolysis UBE2N 2237.026535 2221.738615 2252.314456 1.013762124 0.019719168 0.952361535 1 23.07222125 24.39727932 7334 ubiquitin conjugating enzyme E2 N "GO:0000151,GO:0000187,GO:0000209,GO:0000724,GO:0000729,GO:0001650,GO:0003723,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006282,GO:0006301,GO:0006303,GO:0006511,GO:0007254,GO:0016567,GO:0016574,GO:0031058,GO:0031372,GO:0031625,GO:0032991,GO:0033182,GO:0035370,GO:0043123,GO:0043130,GO:0045739,GO:0050852,GO:0051092,GO:0051443,GO:0061631,GO:0070062,GO:0070423,GO:0070498,GO:0070534" ubiquitin ligase complex|activation of MAPK activity|protein polyubiquitination|double-strand break repair via homologous recombination|DNA double-strand break processing|fibrillar center|RNA binding|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA repair|postreplication repair|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|JNK cascade|protein ubiquitination|histone ubiquitination|positive regulation of histone modification|UBC13-MMS2 complex|ubiquitin protein ligase binding|protein-containing complex|regulation of histone ubiquitination|UBC13-UEV1A complex|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|positive regulation of DNA repair|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein transferase activity|ubiquitin conjugating enzyme activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination "hsa04120,hsa05131" Ubiquitin mediated proteolysis|Shigellosis UBE2O 884.3901202 1152.98998 615.7902603 0.53408119 -0.904869021 0.012471719 0.492832901 10.56729551 5.886905504 63893 ubiquitin conjugating enzyme E2 O "GO:0003723,GO:0004842,GO:0004869,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006513,GO:0010951,GO:0016604,GO:0030513,GO:0042147,GO:0043066,GO:0061630,GO:0061631,GO:0070534" "RNA binding|ubiquitin-protein transferase activity|cysteine-type endopeptidase inhibitor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein monoubiquitination|negative regulation of endopeptidase activity|nuclear body|positive regulation of BMP signaling pathway|retrograde transport, endosome to Golgi|negative regulation of apoptotic process|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination" hsa04120 Ubiquitin mediated proteolysis UBE2Q1 1852.494311 1798.501976 1906.486646 1.060041452 0.084120681 0.796487686 1 28.12219214 31.09481299 55585 ubiquitin conjugating enzyme E2 Q1 "GO:0000209,GO:0001967,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0007566,GO:0007617,GO:0009566,GO:0030175,GO:0061458,GO:0061631,GO:0070459" protein polyubiquitination|suckling behavior|protein binding|ATP binding|nucleus|cytosol|embryo implantation|mating behavior|fertilization|filopodium|reproductive system development|ubiquitin conjugating enzyme activity|prolactin secretion hsa04120 Ubiquitin mediated proteolysis UBE2Q2 1277.351278 1276.814608 1277.887948 1.000840639 0.001212276 0.999805735 1 9.595808811 10.01757142 92912 ubiquitin conjugating enzyme E2 Q2 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0016567,GO:0061631,GO:0070936" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|cytosol|protein ubiquitination|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2R2 2600.907301 2715.007215 2486.807387 0.915948721 -0.126661262 0.691711387 1 30.71376759 29.34405879 54926 ubiquitin conjugating enzyme E2 R2 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005829,GO:0006511,GO:0006513,GO:0016567,GO:0061631,GO:0070936" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|cytosol|ubiquitin-dependent protein catabolic process|protein monoubiquitination|protein ubiquitination|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2S 2629.477494 2378.041834 2880.913154 1.211464455 0.276752076 0.385342239 1 35.47553156 44.82863525 27338 ubiquitin conjugating enzyme E2 S "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005680,GO:0005829,GO:0006464,GO:0006511,GO:0010458,GO:0010994,GO:0010997,GO:0016567,GO:0031145,GO:0035519,GO:0044314,GO:0051301,GO:0061631,GO:0070534,GO:0070979,GO:0085020,GO:1904668" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|anaphase-promoting complex|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|exit from mitosis|free ubiquitin chain polymerization|anaphase-promoting complex binding|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|protein K29-linked ubiquitination|protein K27-linked ubiquitination|cell division|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination|positive regulation of ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE2T 1051.022778 925.6398432 1176.405713 1.270910843 0.345862826 0.322450387 1 53.15237256 70.46178964 29089 ubiquitin conjugating enzyme E2 T "GO:0000209,GO:0003682,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006281,GO:0006513,GO:0006974,GO:0016567,GO:0031625,GO:0035519,GO:0036297,GO:0044314,GO:0051865,GO:0061631,GO:0070534,GO:0070936,GO:0070979,GO:0085020" protein polyubiquitination|chromatin binding|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|DNA repair|protein monoubiquitination|cellular response to DNA damage stimulus|protein ubiquitination|ubiquitin protein ligase binding|protein K29-linked ubiquitination|interstrand cross-link repair|protein K27-linked ubiquitination|protein autoubiquitination|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination hsa03460 Fanconi anemia pathway UBE2V1 60.42501488 55.82257826 65.02745149 1.164895165 0.220200125 0.799273737 1 0.663821709 0.806592582 7335 ubiquitin conjugating enzyme E2 V1 "GO:0000151,GO:0000187,GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006282,GO:0006301,GO:0006355,GO:0007254,GO:0030154,GO:0031371,GO:0032991,GO:0035370,GO:0043123,GO:0045893,GO:0051092,GO:0061631,GO:0070062,GO:0070423,GO:0070498,GO:0070534" "ubiquitin ligase complex|activation of MAPK activity|protein polyubiquitination|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA repair|postreplication repair|regulation of transcription, DNA-templated|JNK cascade|cell differentiation|ubiquitin conjugating enzyme complex|protein-containing complex|UBC13-UEV1A complex|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|positive regulation of NF-kappaB transcription factor activity|ubiquitin conjugating enzyme activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination" hsa05131 Shigellosis UBE2V2 2123.749581 2055.285836 2192.213327 1.066622116 0.093049147 0.772921095 1 23.24022705 25.85632993 7336 ubiquitin conjugating enzyme E2 V2 "GO:0000209,GO:0000729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006282,GO:0006301,GO:0006303,GO:0010976,GO:0016567,GO:0031372,GO:0032436,GO:0042275,GO:0043524,GO:0045739,GO:0051965,GO:0061631,GO:0070062,GO:0070534" protein polyubiquitination|DNA double-strand break processing|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of DNA repair|postreplication repair|double-strand break repair via nonhomologous end joining|positive regulation of neuron projection development|protein ubiquitination|UBC13-MMS2 complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|error-free postreplication DNA repair|negative regulation of neuron apoptotic process|positive regulation of DNA repair|positive regulation of synapse assembly|ubiquitin conjugating enzyme activity|extracellular exosome|protein K63-linked ubiquitination hsa05131 Shigellosis UBE2W 1159.891529 1329.592319 990.1907386 0.744732596 -0.425205592 0.216386037 1 7.622725879 5.921429933 55284 ubiquitin conjugating enzyme E2 W "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0006513,GO:0006515,GO:0016567,GO:0031625,GO:0043161,GO:0061631,GO:0070979,GO:0071218" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|protein monoubiquitination|protein quality control for misfolded or incompletely synthesized proteins|protein ubiquitination|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin conjugating enzyme activity|protein K11-linked ubiquitination|cellular response to misfolded protein hsa04120 Ubiquitin mediated proteolysis UBE2Z 5609.394391 5138.722068 6080.066715 1.183186527 0.242677529 0.452646904 1 84.38980039 104.1499594 65264 ubiquitin conjugating enzyme E2 Z "GO:0004869,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006915,GO:0010951,GO:0016567,GO:0043065,GO:0043066,GO:0061631" cysteine-type endopeptidase inhibitor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|negative regulation of endopeptidase activity|protein ubiquitination|positive regulation of apoptotic process|negative regulation of apoptotic process|ubiquitin conjugating enzyme activity hsa04120 Ubiquitin mediated proteolysis UBE3A 1167.008345 1378.310205 955.7064841 0.693389979 -0.528261108 0.124410737 1 6.066969364 4.387986598 7337 ubiquitin protein ligase E3A "GO:0000502,GO:0001541,GO:0003713,GO:0004842,GO:0005515,GO:0005634,GO:0005829,GO:0006508,GO:0006511,GO:0007420,GO:0014068,GO:0016032,GO:0030521,GO:0031398,GO:0032570,GO:0035037,GO:0042220,GO:0042542,GO:0042752,GO:0045944,GO:0046872,GO:0048511,GO:0050847,GO:0051865,GO:0060736,GO:0061002,GO:0061630,GO:0070936,GO:1905528,GO:1990416,GO:2000058" proteasome complex|ovarian follicle development|transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|nucleus|cytosol|proteolysis|ubiquitin-dependent protein catabolic process|brain development|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|androgen receptor signaling pathway|positive regulation of protein ubiquitination|response to progesterone|sperm entry|response to cocaine|response to hydrogen peroxide|regulation of circadian rhythm|positive regulation of transcription by RNA polymerase II|metal ion binding|rhythmic process|progesterone receptor signaling pathway|protein autoubiquitination|prostate gland growth|negative regulation of dendritic spine morphogenesis|ubiquitin protein ligase activity|protein K48-linked ubiquitination|positive regulation of Golgi lumen acidification|cellular response to brain-derived neurotrophic factor stimulus|regulation of ubiquitin-dependent protein catabolic process "hsa04120,hsa05165,hsa05203" Ubiquitin mediated proteolysis|Human papillomavirus infection|Viral carcinogenesis UBE3B 1469.680237 1358.011086 1581.349389 1.164459853 0.2196609 0.509183438 1 10.44154709 12.68251256 89910 ubiquitin protein ligase E3B "GO:0000209,GO:0004842,GO:0006511,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE3C 3947.235254 3891.341183 4003.129324 1.028727407 0.040860746 0.898684939 1 37.72639799 40.48196471 9690 ubiquitin protein ligase E3C "GO:0000209,GO:0000502,GO:0005515,GO:0005634,GO:0006511,GO:0061630" protein polyubiquitination|proteasome complex|protein binding|nucleus|ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE3D 87.60613938 95.40586103 79.80641774 0.836493868 -0.25757313 0.726647104 1 0.644864579 0.562661519 90025 ubiquitin protein ligase E3D "GO:0000151,GO:0000209,GO:0005515,GO:0005634,GO:0005829,GO:0006513,GO:0030332,GO:0031624,GO:0043161,GO:0044390,GO:0051865,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|protein binding|nucleus|cytosol|protein monoubiquitination|cyclin binding|ubiquitin conjugating enzyme binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-like protein conjugating enzyme binding|protein autoubiquitination|ubiquitin protein ligase activity UBE4A 1849.183457 1942.625723 1755.74119 0.903797973 -0.145927774 0.653415231 1 16.1608311 15.23529907 9354 ubiquitination factor E4A "GO:0000151,GO:0000209,GO:0005515,GO:0005634,GO:0005737,GO:0006511,GO:0030433,GO:0034450" ubiquitin ligase complex|protein polyubiquitination|protein binding|nucleus|cytoplasm|ubiquitin-dependent protein catabolic process|ubiquitin-dependent ERAD pathway|ubiquitin-ubiquitin ligase activity hsa04120 Ubiquitin mediated proteolysis UBE4B 2504.773997 2474.462651 2535.085344 1.024499336 0.03491905 0.914055531 1 17.91861651 19.14838214 10277 ubiquitination factor E4B "GO:0000151,GO:0000209,GO:0005634,GO:0005737,GO:0006511,GO:0008626,GO:0009411,GO:0019899,GO:0030433,GO:0034450,GO:0043161,GO:0051117" ubiquitin ligase complex|protein polyubiquitination|nucleus|cytoplasm|ubiquitin-dependent protein catabolic process|granzyme-mediated apoptotic signaling pathway|response to UV|enzyme binding|ubiquitin-dependent ERAD pathway|ubiquitin-ubiquitin ligase activity|proteasome-mediated ubiquitin-dependent protein catabolic process|ATPase binding "hsa04120,hsa04141" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum UBFD1 1208.196455 1365.115777 1051.277132 0.770101078 -0.376880278 0.270146251 1 13.67180112 10.98220114 56061 ubiquitin family domain containing 1 "GO:0003723,GO:0045296" RNA binding|cadherin binding UBIAD1 467.8679776 529.8070155 405.9289396 0.766182643 -0.384239751 0.355719835 1 3.211208268 2.566354888 29914 UbiA prenyltransferase domain containing 1 "GO:0004659,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0006744,GO:0009234,GO:0016020,GO:0016209,GO:0030173,GO:0031966,GO:0032194,GO:0042371,GO:0042373,GO:0098869" "prenyltransferase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|ubiquinone biosynthetic process|menaquinone biosynthetic process|membrane|antioxidant activity|integral component of Golgi membrane|mitochondrial membrane|ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate|vitamin K biosynthetic process|vitamin K metabolic process|cellular oxidant detoxification" UBL3 382.9382833 381.6234441 384.2531225 1.006890767 0.009907181 0.988736962 1 4.4771557 4.702193386 5412 ubiquitin like 3 "GO:0005515,GO:0005886,GO:0070062" protein binding|plasma membrane|extracellular exosome UBL4A 1399.08389 1549.837764 1248.330016 0.80545851 -0.312117819 0.350980732 1 33.73176417 28.33988995 8266 ubiquitin like 4A "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0016020,GO:0018215,GO:0019787,GO:0051087,GO:0071816,GO:0071818" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|membrane|protein phosphopantetheinylation|ubiquitin-like protein transferase activity|chaperone binding|tail-anchored membrane protein insertion into ER membrane|BAT3 complex UBL5 1110.419229 1146.900244 1073.938214 0.936383281 -0.094828919 0.786105404 1 142.7185537 139.3959053 59286 ubiquitin like 5 "GO:0000398,GO:0005515,GO:0005634,GO:0005737,GO:0006464,GO:0031386,GO:1903955" "mRNA splicing, via spliceosome|protein binding|nucleus|cytoplasm|cellular protein modification process|protein tag|positive regulation of protein targeting to mitochondrion" UBL7 1224.288777 1185.468571 1263.108982 1.065493437 0.091521706 0.790175899 1 33.71128638 37.46640588 84993 ubiquitin like 7 "GO:0005515,GO:0005829,GO:0006511,GO:0031593" protein binding|cytosol|ubiquitin-dependent protein catabolic process|polyubiquitin modification-dependent protein binding UBLCP1 856.319733 850.5331015 862.1063645 1.013607069 0.019498492 0.960585175 1 19.7689312 20.90108111 134510 ubiquitin like domain containing CTD phosphatase 1 "GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006470,GO:0106306,GO:0106307" protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|protein dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity UBN1 1237.183567 1225.051854 1249.31528 1.01980604 0.028294788 0.936213106 1 7.699746174 8.19049064 29855 ubinuclein 1 "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005923,GO:0006336,GO:0016032,GO:0016604,GO:0016605,GO:0034451" DNA binding|protein binding|nucleus|nucleoplasm|bicellular tight junction|DNA replication-independent nucleosome assembly|viral process|nuclear body|PML body|centriolar satellite other UBN2 426.3614249 420.1917709 432.5310789 1.029365896 0.041755891 0.927568019 1 1.827813351 1.962535632 254048 ubinuclein 2 "GO:0005615,GO:0005654" extracellular space|nucleoplasm UBOX5 373.4649483 306.5167024 440.4131942 1.436832612 0.522892001 0.237486667 1 3.610230152 5.410744111 22888 U-box domain containing 5 "GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005925,GO:0016604,GO:0031625,GO:0034450,GO:0046872" protein polyubiquitination|protein binding|nucleus|nucleoplasm|focal adhesion|nuclear body|ubiquitin protein ligase binding|ubiquitin-ubiquitin ligase activity|metal ion binding hsa04120 Ubiquitin mediated proteolysis UBP1 3450.386845 3603.093688 3297.680002 0.915235708 -0.127784755 0.688306707 1 43.70873876 41.72699986 7342 upstream binding protein 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0032897,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|negative regulation of viral transcription|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" CP2 UBQLN1 4206.788593 4493.210072 3920.367113 0.872509197 -0.196757756 0.537645942 1 45.39502076 41.31370674 29979 ubiquilin 1 "GO:0000045,GO:0000502,GO:0005515,GO:0005654,GO:0005737,GO:0005776,GO:0005783,GO:0005829,GO:0005886,GO:0006511,GO:0016235,GO:0016236,GO:0016241,GO:0019900,GO:0030433,GO:0031396,GO:0031398,GO:0031410,GO:0031593,GO:0032991,GO:0034976,GO:0035973,GO:0042802,GO:0048471,GO:0071456,GO:0097352,GO:1901340,GO:1902175,GO:1903071" autophagosome assembly|proteasome complex|protein binding|nucleoplasm|cytoplasm|autophagosome|endoplasmic reticulum|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|aggresome|macroautophagy|regulation of macroautophagy|kinase binding|ubiquitin-dependent ERAD pathway|regulation of protein ubiquitination|positive regulation of protein ubiquitination|cytoplasmic vesicle|polyubiquitin modification-dependent protein binding|protein-containing complex|response to endoplasmic reticulum stress|aggrephagy|identical protein binding|perinuclear region of cytoplasm|cellular response to hypoxia|autophagosome maturation|negative regulation of store-operated calcium channel activity|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of ER-associated ubiquitin-dependent protein catabolic process "hsa04141,hsa05014" Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis UBQLN2 1471.30387 1401.654192 1540.953547 1.099382113 0.136692912 0.681912115 1 16.73475721 19.19039935 29978 ubiquilin 2 "GO:0000045,GO:0005515,GO:0005634,GO:0005737,GO:0005776,GO:0005829,GO:0005886,GO:0006511,GO:0016241,GO:0030433,GO:0031410,GO:0031593,GO:0042802,GO:1900186,GO:1903071,GO:1904021,GO:2000785" autophagosome assembly|protein binding|nucleus|cytoplasm|autophagosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|regulation of macroautophagy|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|polyubiquitin modification-dependent protein binding|identical protein binding|negative regulation of clathrin-dependent endocytosis|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of G protein-coupled receptor internalization|regulation of autophagosome assembly "hsa04141,hsa05014" Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis UBQLN4 1285.574846 1300.158595 1270.991097 0.9775662 -0.032733691 0.925284753 1 17.37426021 17.71611245 56893 ubiquilin 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005776,GO:0005789,GO:0005829,GO:0006281,GO:0006511,GO:0006914,GO:0006974,GO:0031410,GO:0031593,GO:0031595,GO:0031597,GO:0032434,GO:0032991,GO:0036435,GO:0042802,GO:0048471,GO:0090734,GO:1901097,GO:2000042" protein binding|nucleus|nucleoplasm|cytoplasm|autophagosome|endoplasmic reticulum membrane|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|autophagy|cellular response to DNA damage stimulus|cytoplasmic vesicle|polyubiquitin modification-dependent protein binding|nuclear proteasome complex|cytosolic proteasome complex|regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|K48-linked polyubiquitin modification-dependent protein binding|identical protein binding|perinuclear region of cytoplasm|site of DNA damage|negative regulation of autophagosome maturation|negative regulation of double-strand break repair via homologous recombination "hsa04141,hsa05014" Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis UBR1 929.6543841 946.9539185 912.3548497 0.963462775 -0.053699169 0.88323621 1 6.230173463 6.261105299 197131 ubiquitin protein ligase E3 component n-recognin 1 "GO:0000151,GO:0000502,GO:0005515,GO:0005737,GO:0005829,GO:0008270,GO:0016567,GO:0032007,GO:0061630,GO:0070728,GO:0071233,GO:0071596" ubiquitin ligase complex|proteasome complex|protein binding|cytoplasm|cytosol|zinc ion binding|protein ubiquitination|negative regulation of TOR signaling|ubiquitin protein ligase activity|leucine binding|cellular response to leucine|ubiquitin-dependent protein catabolic process via the N-end rule pathway UBR2 772.8530896 701.3345741 844.371605 1.203949778 0.267775212 0.469933807 1 3.880708185 4.873436228 23304 ubiquitin protein ligase E3 component n-recognin 2 "GO:0000151,GO:0000209,GO:0000785,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006342,GO:0007131,GO:0007140,GO:0007141,GO:0007283,GO:0008270,GO:0010529,GO:0016567,GO:0032007,GO:0033522,GO:0061630,GO:0070728,GO:0071233,GO:0071596" ubiquitin ligase complex|protein polyubiquitination|chromatin|protein binding|nucleus|cytoplasm|cytosol|chromatin silencing|reciprocal meiotic recombination|male meiotic nuclear division|male meiosis I|spermatogenesis|zinc ion binding|negative regulation of transposition|protein ubiquitination|negative regulation of TOR signaling|histone H2A ubiquitination|ubiquitin protein ligase activity|leucine binding|cellular response to leucine|ubiquitin-dependent protein catabolic process via the N-end rule pathway UBR3 702.1070467 714.5290017 689.6850916 0.965230368 -0.051054788 0.896035085 1 4.144339582 4.172556642 130507 ubiquitin protein ligase E3 component n-recognin 3 "GO:0000151,GO:0001967,GO:0004842,GO:0005737,GO:0006511,GO:0007608,GO:0008270,GO:0009792,GO:0016021,GO:0016567,GO:0061630,GO:0071596" ubiquitin ligase complex|suckling behavior|ubiquitin-protein transferase activity|cytoplasm|ubiquitin-dependent protein catabolic process|sensory perception of smell|zinc ion binding|embryo development ending in birth or egg hatching|integral component of membrane|protein ubiquitination|ubiquitin protein ligase activity|ubiquitin-dependent protein catabolic process via the N-end rule pathway UBR4 7454.404701 6998.121402 7910.688 1.130401653 0.17683548 0.590931549 1 22.13666611 26.10122728 23352 ubiquitin protein ligase E3 component n-recognin 4 "GO:0004842,GO:0005515,GO:0005516,GO:0005654,GO:0005813,GO:0005829,GO:0005886,GO:0006511,GO:0008270,GO:0016020,GO:0016021,GO:0016032,GO:0016567,GO:0035579,GO:0043312,GO:0061630,GO:0070821,GO:0101003" ubiquitin-protein transferase activity|protein binding|calmodulin binding|nucleoplasm|centrosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|zinc ion binding|membrane|integral component of membrane|viral process|protein ubiquitination|specific granule membrane|neutrophil degranulation|ubiquitin protein ligase activity|tertiary granule membrane|ficolin-1-rich granule membrane "hsa05165,hsa05203" Human papillomavirus infection|Viral carcinogenesis UBR5 5994.058498 6143.528477 5844.588519 0.951340674 -0.071966035 0.824747987 1 29.384082 29.15842904 51366 ubiquitin protein ligase E3 component n-recognin 5 "GO:0000209,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0008270,GO:0010628,GO:0016020,GO:0016032,GO:0032991,GO:0034450,GO:0042307,GO:0043130,GO:0048471,GO:0050847,GO:0061630,GO:0070936,GO:0090263,GO:1901315,GO:2000779,GO:2000780" protein polyubiquitination|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|zinc ion binding|positive regulation of gene expression|membrane|viral process|protein-containing complex|ubiquitin-ubiquitin ligase activity|positive regulation of protein import into nucleus|ubiquitin binding|perinuclear region of cytoplasm|progesterone receptor signaling pathway|ubiquitin protein ligase activity|protein K48-linked ubiquitination|positive regulation of canonical Wnt signaling pathway|negative regulation of histone H2A K63-linked ubiquitination|regulation of double-strand break repair|negative regulation of double-strand break repair hsa04120 Ubiquitin mediated proteolysis UBR7 1279.154544 1130.660949 1427.64814 1.262666886 0.336474081 0.320781356 1 16.38923535 21.5855646 55148 ubiquitin protein ligase E3 component n-recognin 7 "GO:0003674,GO:0005737,GO:0008150,GO:0008270,GO:0016567,GO:0061630" molecular_function|cytoplasm|biological_process|zinc ion binding|protein ubiquitination|ubiquitin protein ligase activity UBTD1 1529.138793 1549.837764 1508.439822 0.973288855 -0.039060061 0.907907393 1 47.65866134 48.38374932 80019 ubiquitin domain containing 1 GO:0005515 protein binding UBTD2 1327.318931 1426.013136 1228.624727 0.861580231 -0.214942947 0.524140982 1 22.88419982 20.56588423 92181 ubiquitin domain containing 2 "GO:0005515,GO:0005737" protein binding|cytoplasm UBTF 2390.774797 2561.748864 2219.80073 0.866517699 -0.206698878 0.517826233 1 24.92671329 22.52985443 7343 upstream binding transcription factor "GO:0001164,GO:0001165,GO:0001181,GO:0001188,GO:0001650,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0045943,GO:0097110,GO:1902659" RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I cis-regulatory region sequence-specific DNA binding|RNA polymerase I general transcription initiation factor activity|RNA polymerase I preinitiation complex assembly|fibrillar center|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|positive regulation of transcription by RNA polymerase I|scaffold protein binding|regulation of glucose mediated signaling pathway HMG UBXN1 1705.487515 1717.305498 1693.669532 0.986236598 -0.019994305 0.953103203 1 68.80970349 70.7858955 51035 UBX domain protein 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006457,GO:0016032,GO:0030425,GO:0031397,GO:0031593,GO:0031625,GO:0032435,GO:0034098,GO:0036435,GO:0043025,GO:0043130,GO:0043161,GO:0051117,GO:0071796,GO:1903094,GO:1904293,GO:1904855,GO:2000157" protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|protein folding|viral process|dendrite|negative regulation of protein ubiquitination|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|VCP-NPL4-UFD1 AAA ATPase complex|K48-linked polyubiquitin modification-dependent protein binding|neuronal cell body|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ATPase binding|K6-linked polyubiquitin modification-dependent protein binding|negative regulation of protein K48-linked deubiquitination|negative regulation of ERAD pathway|proteasome regulatory particle binding|negative regulation of ubiquitin-specific protease activity hsa04141 Protein processing in endoplasmic reticulum UBXN11 204.6811366 184.7219862 224.640287 1.216099348 0.282261093 0.601852492 1 4.467773134 5.667298627 91544 UBX domain protein 11 "GO:0005515,GO:0005737,GO:0005856,GO:0043130,GO:0043161" protein binding|cytoplasm|cytoskeleton|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process UBXN2A 466.4158131 396.8477836 535.9838426 1.350603089 0.433603763 0.297563798 1 6.749140445 9.508064828 165324 UBX domain protein 2A "GO:0000045,GO:0005515,GO:0005634,GO:0005783,GO:0005801,GO:0005829,GO:0007030,GO:0010468,GO:0031396,GO:0031468,GO:0033130,GO:0042176,GO:0043130,GO:0043161,GO:0061025,GO:1990830" autophagosome assembly|protein binding|nucleus|endoplasmic reticulum|cis-Golgi network|cytosol|Golgi organization|regulation of gene expression|regulation of protein ubiquitination|nuclear envelope reassembly|acetylcholine receptor binding|regulation of protein catabolic process|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|membrane fusion|cellular response to leukemia inhibitory factor hsa04141 Protein processing in endoplasmic reticulum UBXN2B 1097.942842 1102.242182 1093.643502 0.99219892 -0.011298708 0.976927691 1 10.70053249 11.07439653 137886 UBX domain protein 2B "GO:0000045,GO:0000132,GO:0005515,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0007030,GO:0031468,GO:0031616,GO:0043130,GO:0043161,GO:0046604,GO:0061025,GO:1904780" autophagosome assembly|establishment of mitotic spindle orientation|protein binding|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|Golgi organization|nuclear envelope reassembly|spindle pole centrosome|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of mitotic centrosome separation|membrane fusion|negative regulation of protein localization to centrosome UBXN4 2039.010161 1953.790239 2124.230082 1.087235487 0.120664451 0.708545532 1 26.24040919 29.75843939 23190 UBX domain protein 4 "GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005829,GO:0006986,GO:0030433" protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|response to unfolded protein|ubiquitin-dependent ERAD pathway hsa04141 Protein processing in endoplasmic reticulum UBXN6 1438.941324 1378.310205 1499.572442 1.087978915 0.121650598 0.716338753 1 26.77658209 30.38726051 80700 UBX domain protein 6 "GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005768,GO:0005815,GO:0005829,GO:0016236,GO:0019898,GO:0031901,GO:0031902,GO:0032510,GO:0032991,GO:0036503,GO:0070062" protein binding|nucleus|cytoplasm|lysosomal membrane|endosome|microtubule organizing center|cytosol|macroautophagy|extrinsic component of membrane|early endosome membrane|late endosome membrane|endosome to lysosome transport via multivesicular body sorting pathway|protein-containing complex|ERAD pathway|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum UBXN7 2762.301876 2466.343003 3058.260749 1.239998145 0.310337962 0.329925372 1 11.7619183 15.21300905 26043 UBX domain protein 7 "GO:0005515,GO:0005654,GO:0005829,GO:0008134,GO:0016604,GO:0031625,GO:0034098,GO:0043130,GO:0043687" protein binding|nucleoplasm|cytosol|transcription factor binding|nuclear body|ubiquitin protein ligase binding|VCP-NPL4-UFD1 AAA ATPase complex|ubiquitin binding|post-translational protein modification UBXN8 94.04004964 97.43577296 90.64432632 0.930298222 -0.104234826 0.895068434 1 1.868526379 1.813165112 7993 UBX domain protein 8 "GO:0000151,GO:0005515,GO:0005654,GO:0005730,GO:0005783,GO:0007338,GO:0030176,GO:0030433,GO:0030674" ubiquitin ligase complex|protein binding|nucleoplasm|nucleolus|endoplasmic reticulum|single fertilization|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|protein-macromolecule adaptor activity hsa04141 Protein processing in endoplasmic reticulum UCHL1 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.233018764 0.047189178 7345 ubiquitin C-terminal hydrolase L1 "GO:0004197,GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0008242,GO:0016241,GO:0016579,GO:0016874,GO:0018215,GO:0031625,GO:0031694,GO:0043130,GO:0043161,GO:0043407" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|omega peptidase activity|regulation of macroautophagy|protein deubiquitination|ligase activity|protein phosphopantetheinylation|ubiquitin protein ligase binding|alpha-2A adrenergic receptor binding|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of MAP kinase activity "hsa05012,hsa05022" Parkinson disease|Pathways of neurodegeneration - multiple diseases UCHL3 496.2300832 549.0911789 443.3689874 0.80745968 -0.308537874 0.452060701 1 6.605589343 5.563503247 7347 ubiquitin C-terminal hydrolase L3 "GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0008233,GO:0016567,GO:0016579,GO:0018215,GO:0019784,GO:0030163,GO:0043130,GO:0043687" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|peptidase activity|protein ubiquitination|protein deubiquitination|protein phosphopantetheinylation|NEDD8-specific protease activity|protein catabolic process|ubiquitin binding|post-translational protein modification UCHL5 948.2150639 1070.778547 825.6515811 0.771075946 -0.375055131 0.291839645 1 7.415719391 5.964394665 51377 ubiquitin C-terminal hydrolase L5 "GO:0000502,GO:0003723,GO:0004843,GO:0004866,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006281,GO:0006310,GO:0006511,GO:0008234,GO:0010951,GO:0016579,GO:0018215,GO:0031011,GO:0032435,GO:0045880,GO:0061136,GO:0070628" proteasome complex|RNA binding|thiol-dependent ubiquitin-specific protease activity|endopeptidase inhibitor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|DNA repair|DNA recombination|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|negative regulation of endopeptidase activity|protein deubiquitination|protein phosphopantetheinylation|Ino80 complex|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of smoothened signaling pathway|regulation of proteasomal protein catabolic process|proteasome binding UCK1 874.6483235 891.1313402 858.1653068 0.963006538 -0.054382502 0.883227116 1 20.47761282 20.56953588 83549 uridine-cytidine kinase 1 "GO:0004849,GO:0005524,GO:0005829,GO:0016301,GO:0016310,GO:0043097,GO:0044206,GO:0044211" uridine kinase activity|ATP binding|cytosol|kinase activity|phosphorylation|pyrimidine nucleoside salvage|UMP salvage|CTP salvage "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes UCK2 1284.48294 1326.547451 1242.418429 0.936580466 -0.094525147 0.781757274 1 13.33299238 13.02532763 7371 uridine-cytidine kinase 2 "GO:0004849,GO:0005524,GO:0005575,GO:0005829,GO:0016301,GO:0016310,GO:0042802,GO:0043097,GO:0044206,GO:0044211" uridine kinase activity|ATP binding|cellular_component|cytosol|kinase activity|phosphorylation|identical protein binding|pyrimidine nucleoside salvage|UMP salvage|CTP salvage "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes UCKL1 1597.477098 1405.714016 1789.24018 1.272833706 0.348043945 0.290325226 1 16.30656341 21.64960818 54963 uridine-cytidine kinase 1 like 1 "GO:0004849,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0016032,GO:0016301,GO:0016310,GO:0043097,GO:0044206,GO:0044211" uridine kinase activity|protein binding|ATP binding|nucleus|cytosol|viral process|kinase activity|phosphorylation|pyrimidine nucleoside salvage|UMP salvage|CTP salvage "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes UCN 8.030573092 10.14955968 5.911586499 0.582447582 -0.779799875 0.654071524 1 0.646590431 0.392827651 7349 urocortin "GO:0001964,GO:0005184,GO:0005515,GO:0005576,GO:0006954,GO:0006979,GO:0007186,GO:0007218,GO:0007565,GO:0007605,GO:0008306,GO:0009060,GO:0010629,GO:0010996,GO:0030157,GO:0030307,GO:0030425,GO:0031064,GO:0031175,GO:0032099,GO:0032355,GO:0032755,GO:0032967,GO:0033138,GO:0034199,GO:0035176,GO:0035483,GO:0042756,GO:0043066,GO:0043117,GO:0043196,GO:0043204,GO:0043679,GO:0043950,GO:0045727,GO:0045740,GO:0045776,GO:0045792,GO:0045944,GO:0046811,GO:0046888,GO:0048265,GO:0051384,GO:0051430,GO:0051431,GO:0051461,GO:0051966,GO:0060452,GO:0060455,GO:0060547,GO:0090280,GO:1901215,GO:2000252,GO:2000987" "startle response|neuropeptide hormone activity|protein binding|extracellular region|inflammatory response|response to oxidative stress|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|female pregnancy|sensory perception of sound|associative learning|aerobic respiration|negative regulation of gene expression|response to auditory stimulus|pancreatic juice secretion|positive regulation of cell growth|dendrite|negative regulation of histone deacetylation|neuron projection development|negative regulation of appetite|response to estradiol|positive regulation of interleukin-6 production|positive regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|activation of protein kinase A activity|social behavior|gastric emptying|drinking behavior|negative regulation of apoptotic process|positive regulation of vascular permeability|varicosity|perikaryon|axon terminus|positive regulation of cAMP-mediated signaling|positive regulation of translation|positive regulation of DNA replication|negative regulation of blood pressure|negative regulation of cell size|positive regulation of transcription by RNA polymerase II|histone deacetylase inhibitor activity|negative regulation of hormone secretion|response to pain|response to glucocorticoid|corticotropin-releasing hormone receptor 1 binding|corticotropin-releasing hormone receptor 2 binding|positive regulation of corticotropin secretion|regulation of synaptic transmission, glutamatergic|positive regulation of cardiac muscle contraction|negative regulation of gastric acid secretion|negative regulation of necrotic cell death|positive regulation of calcium ion import|negative regulation of neuron death|negative regulation of feeding behavior|positive regulation of behavioral fear response" hsa04080 Neuroactive ligand-receptor interaction UCN2 133.7272528 183.7070303 83.74747541 0.45587518 -1.133289232 0.067081087 1 6.211023367 2.953418835 90226 urocortin 2 "GO:0005179,GO:0005576,GO:0005615,GO:0007189,GO:0007586,GO:0009755,GO:0031669,GO:0042562,GO:0051429,GO:0051431" hormone activity|extracellular region|extracellular space|adenylate cyclase-activating G protein-coupled receptor signaling pathway|digestion|hormone-mediated signaling pathway|cellular response to nutrient levels|hormone binding|corticotropin-releasing hormone receptor binding|corticotropin-releasing hormone receptor 2 binding hsa04080 Neuroactive ligand-receptor interaction UCP1 7.956344212 5.074779842 10.83790858 2.135641135 1.094669242 0.504649292 1 0.044321382 0.098731902 7350 uncoupling protein 1 "GO:0002024,GO:0005739,GO:0005743,GO:0006357,GO:0009266,GO:0009409,GO:0016021,GO:0017077,GO:0022857,GO:0031667,GO:0032555,GO:0032870,GO:0034614,GO:0036041,GO:0050873,GO:0070417,GO:0071398,GO:0120162,GO:1901612,GO:1902600,GO:1903426,GO:1990542,GO:1990845" diet induced thermogenesis|mitochondrion|mitochondrial inner membrane|regulation of transcription by RNA polymerase II|response to temperature stimulus|response to cold|integral component of membrane|oxidative phosphorylation uncoupler activity|transmembrane transporter activity|response to nutrient levels|purine ribonucleotide binding|cellular response to hormone stimulus|cellular response to reactive oxygen species|long-chain fatty acid binding|brown fat cell differentiation|cellular response to cold|cellular response to fatty acid|positive regulation of cold-induced thermogenesis|cardiolipin binding|proton transmembrane transport|regulation of reactive oxygen species biosynthetic process|mitochondrial transmembrane transport|adaptive thermogenesis "hsa03320,hsa04371,hsa04714,hsa05016" PPAR signaling pathway|Apelin signaling pathway|Thermogenesis|Huntington disease UCP2 624.0106148 797.7553911 450.2658384 0.564415914 -0.825169428 0.033783281 0.826279917 19.71864141 11.60892939 7351 uncoupling protein 2 "GO:0000303,GO:0001666,GO:0005515,GO:0005739,GO:0005743,GO:0007565,GO:0007568,GO:0009409,GO:0010942,GO:0016021,GO:0017077,GO:0032869,GO:0034198,GO:0043066,GO:0051881,GO:0061179,GO:0070542,GO:0071333,GO:0097421,GO:0120162,GO:1902600,GO:1990542,GO:1990845" response to superoxide|response to hypoxia|protein binding|mitochondrion|mitochondrial inner membrane|female pregnancy|aging|response to cold|positive regulation of cell death|integral component of membrane|oxidative phosphorylation uncoupler activity|cellular response to insulin stimulus|cellular response to amino acid starvation|negative regulation of apoptotic process|regulation of mitochondrial membrane potential|negative regulation of insulin secretion involved in cellular response to glucose stimulus|response to fatty acid|cellular response to glucose stimulus|liver regeneration|positive regulation of cold-induced thermogenesis|proton transmembrane transport|mitochondrial transmembrane transport|adaptive thermogenesis UCP3 8.00088154 8.119647747 7.882115332 0.970745971 -0.042834281 1 1 0.122499706 0.124038519 7352 uncoupling protein 3 "GO:0000303,GO:0001666,GO:0005215,GO:0005515,GO:0005739,GO:0005743,GO:0006629,GO:0006631,GO:0007568,GO:0007584,GO:0007585,GO:0009409,GO:0014823,GO:0016021,GO:0017077,GO:0032868,GO:0032870,GO:0051384,GO:1902600,GO:1990542,GO:1990845" response to superoxide|response to hypoxia|transporter activity|protein binding|mitochondrion|mitochondrial inner membrane|lipid metabolic process|fatty acid metabolic process|aging|response to nutrient|respiratory gaseous exchange by respiratory system|response to cold|response to activity|integral component of membrane|oxidative phosphorylation uncoupler activity|response to insulin|cellular response to hormone stimulus|response to glucocorticoid|proton transmembrane transport|mitochondrial transmembrane transport|adaptive thermogenesis UEVLD 767.3720306 730.7682972 803.9757639 1.100178767 0.137737964 0.712211838 1 7.952478784 9.126026125 55293 UEV and lactate/malate dehyrogenase domains "GO:0003674,GO:0005975,GO:0006464,GO:0008150,GO:0015031,GO:0016616,GO:0019752,GO:0055114,GO:0070062" "molecular_function|carbohydrate metabolic process|cellular protein modification process|biological_process|protein transport|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|carboxylic acid metabolic process|oxidation-reduction process|extracellular exosome" UFC1 1227.452411 1199.677955 1255.226867 1.046303186 0.065300961 0.850135104 1 42.10634525 45.95375715 51506 ubiquitin-fold modifier conjugating enzyme 1 "GO:0005515,GO:0007420,GO:0018215,GO:0034976,GO:0061657,GO:0061709,GO:0070062,GO:0071568,GO:0071569,GO:1990592" protein binding|brain development|protein phosphopantetheinylation|response to endoplasmic reticulum stress|UFM1 conjugating enzyme activity|reticulophagy|extracellular exosome|UFM1 transferase activity|protein ufmylation|protein K69-linked ufmylation UFD1 1279.578145 1429.058003 1130.098286 0.790799452 -0.338616224 0.317653947 1 35.32296069 29.13663459 7353 ubiquitin recognition factor in ER associated degradation 1 "GO:0001501,GO:0004843,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0016579,GO:0018215,GO:0030433,GO:0030970,GO:0031593,GO:0032480,GO:0034098,GO:0036435,GO:0036501,GO:0039536,GO:0044877,GO:0051117,GO:0070987,GO:0071712" "skeletal system development|thiol-dependent ubiquitin-specific protease activity|signaling receptor binding|protein binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|polyubiquitin modification-dependent protein binding|negative regulation of type I interferon production|VCP-NPL4-UFD1 AAA ATPase complex|K48-linked polyubiquitin modification-dependent protein binding|UFD1-NPL4 complex|negative regulation of RIG-I signaling pathway|protein-containing complex binding|ATPase binding|error-free translesion synthesis|ER-associated misfolded protein catabolic process" hsa04141 Protein processing in endoplasmic reticulum UFL1 685.4520694 653.6316436 717.2724952 1.09736501 0.134043481 0.726351536 1 7.833444599 8.966435206 23376 UFM1 specific ligase 1 "GO:0001649,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006281,GO:0006974,GO:0008284,GO:0010508,GO:0016020,GO:0016570,GO:0018215,GO:0019901,GO:0030218,GO:0031397,GO:0032088,GO:0032434,GO:0032880,GO:0032991,GO:0033146,GO:0034976,GO:0035861,GO:0043005,GO:0043066,GO:0043122,GO:0050727,GO:0060218,GO:0060252,GO:0061666,GO:0061709,GO:0071568,GO:0071569,GO:1902065,GO:1903895,GO:1990592" osteoblast differentiation|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|DNA repair|cellular response to DNA damage stimulus|positive regulation of cell population proliferation|positive regulation of autophagy|membrane|histone modification|protein phosphopantetheinylation|protein kinase binding|erythrocyte differentiation|negative regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of protein localization|protein-containing complex|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|site of double-strand break|neuron projection|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of inflammatory response|hematopoietic stem cell differentiation|positive regulation of glial cell proliferation|UFM1 ligase activity|reticulophagy|UFM1 transferase activity|protein ufmylation|response to L-glutamate|negative regulation of IRE1-mediated unfolded protein response|protein K69-linked ufmylation UFM1 1025.959156 1098.182358 953.7359552 0.868467744 -0.203455828 0.562889092 1 14.49167855 13.12769006 51569 ubiquitin fold modifier 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0007420,GO:0033146,GO:0034976,GO:0042308,GO:0043066,GO:0061709,GO:0071569,GO:1990592" protein binding|nucleus|cytoplasm|endoplasmic reticulum|brain development|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|negative regulation of protein import into nucleus|negative regulation of apoptotic process|reticulophagy|protein ufmylation|protein K69-linked ufmylation UFSP1 22.49505644 22.3290313 22.66108158 1.014870787 0.021296056 1 1 1.136569511 1.203158056 402682 UFM1 specific peptidase 1 (inactive) "GO:0003674,GO:0005515,GO:0008150" molecular_function|protein binding|biological_process UFSP2 389.3100888 413.0870791 365.5330985 0.884881462 -0.176443889 0.68986662 1 8.861246622 8.178917931 55325 UFM1 specific peptidase 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0006508,GO:0016790,GO:0033146,GO:0071567" protein binding|nucleus|cytoplasm|endoplasmic reticulum|proteolysis|thiolester hydrolase activity|regulation of intracellular estrogen receptor signaling pathway|UFM1 hydrolase activity UGCG 4559.342032 4212.067269 4906.616794 1.164895165 0.220200125 0.491347895 1 42.32665633 51.43002485 7357 UDP-glucose ceramide glucosyltransferase "GO:0000139,GO:0005515,GO:0006497,GO:0006679,GO:0006687,GO:0008120,GO:0008544,GO:0009966,GO:0016020,GO:0016021,GO:0030154,GO:0030216,GO:0033210,GO:0048666,GO:0061436,GO:0098856,GO:0102769,GO:1903575" Golgi membrane|protein binding|protein lipidation|glucosylceramide biosynthetic process|glycosphingolipid metabolic process|ceramide glucosyltransferase activity|epidermis development|regulation of signal transduction|membrane|integral component of membrane|cell differentiation|keratinocyte differentiation|leptin-mediated signaling pathway|neuron development|establishment of skin barrier|intestinal lipid absorption|dihydroceramide glucosyltransferase activity|cornified envelope assembly hsa00600 Sphingolipid metabolism UGDH 739.5646619 682.0504107 797.078913 1.168651027 0.224844188 0.548188899 1 11.17187813 13.61842754 7358 UDP-glucose 6-dehydrogenase "GO:0001702,GO:0003979,GO:0005634,GO:0005654,GO:0005829,GO:0005975,GO:0006024,GO:0006065,GO:0015012,GO:0030206,GO:0034214,GO:0042802,GO:0048666,GO:0051287,GO:0055114,GO:0070062" gastrulation with mouth forming second|UDP-glucose 6-dehydrogenase activity|nucleus|nucleoplasm|cytosol|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|UDP-glucuronate biosynthetic process|heparan sulfate proteoglycan biosynthetic process|chondroitin sulfate biosynthetic process|protein hexamerization|identical protein binding|neuron development|NAD binding|oxidation-reduction process|extracellular exosome "hsa00040,hsa00053,hsa00520" Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Amino sugar and nucleotide sugar metabolism UGGT1 3663.604549 4000.956427 3326.25267 0.831364383 -0.266447154 0.402604092 1 17.04528335 14.78126385 56886 UDP-glucose glycoprotein glucosyltransferase 1 "GO:0003980,GO:0005515,GO:0005783,GO:0005788,GO:0005793,GO:0018279,GO:0032991,GO:0044322,GO:0051082,GO:0051084,GO:0070062,GO:0071712,GO:0097359,GO:1904380" UDP-glucose:glycoprotein glucosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation via asparagine|protein-containing complex|endoplasmic reticulum quality control compartment|unfolded protein binding|'de novo' posttranslational protein folding|extracellular exosome|ER-associated misfolded protein catabolic process|UDP-glucosylation|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum UGGT2 739.2474574 727.7234293 750.7714854 1.03167145 0.044983598 0.907664649 1 5.973520979 6.428175647 55757 UDP-glucose glycoprotein glucosyltransferase 2 "GO:0003980,GO:0005515,GO:0005783,GO:0005788,GO:0005793,GO:0018279,GO:0032991,GO:0044322,GO:0051082,GO:0071712,GO:0097359,GO:1904380" UDP-glucose:glycoprotein glucosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation via asparagine|protein-containing complex|endoplasmic reticulum quality control compartment|unfolded protein binding|ER-associated misfolded protein catabolic process|UDP-glucosylation|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum UGP2 965.8337787 1029.165352 902.5022056 0.87692634 -0.18947243 0.594174892 1 18.44430092 16.87101626 7360 UDP-glucose pyrophosphorylase 2 "GO:0003983,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005977,GO:0005978,GO:0006011,GO:0006065,GO:0007420,GO:0042802,GO:0046872,GO:0070062" UTP:glucose-1-phosphate uridylyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|glycogen metabolic process|glycogen biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|brain development|identical protein binding|metal ion binding|extracellular exosome "hsa00040,hsa00052,hsa00500,hsa00520" Pentose and glucuronate interconversions|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism UGT2B7 6.030352707 8.119647747 3.941057666 0.485372985 -1.042834281 0.589955466 1 0.182932168 0.09261506 7364 UDP glucuronosyltransferase family 2 member B7 "GO:0001972,GO:0005789,GO:0006629,GO:0008194,GO:0008209,GO:0008210,GO:0015020,GO:0016020,GO:0016021,GO:0043231,GO:0052695" retinoic acid binding|endoplasmic reticulum membrane|lipid metabolic process|UDP-glycosyltransferase activity|androgen metabolic process|estrogen metabolic process|glucuronosyltransferase activity|membrane|integral component of membrane|intracellular membrane-bounded organelle|cellular glucuronidation "hsa00040,hsa00053,hsa00140,hsa00830,hsa00860,hsa00980,hsa00982,hsa00983,hsa04976,hsa05204" Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Steroid hormone biosynthesis|Retinol metabolism|Porphyrin and chlorophyll metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Bile secretion|Chemical carcinogenesis UGT8 721.9162554 721.6336935 722.1988173 1.000783117 0.001129357 1 1 3.972198762 4.146549668 7368 UDP glycosyltransferase 8 "GO:0002175,GO:0003851,GO:0005783,GO:0005886,GO:0006682,GO:0006687,GO:0007010,GO:0007417,GO:0007422,GO:0008194,GO:0008489,GO:0016021,GO:0030913,GO:0043231,GO:0047263,GO:0048812" "protein localization to paranode region of axon|2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|endoplasmic reticulum|plasma membrane|galactosylceramide biosynthetic process|glycosphingolipid metabolic process|cytoskeleton organization|central nervous system development|peripheral nervous system development|UDP-glycosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity|integral component of membrane|paranodal junction assembly|intracellular membrane-bounded organelle|N-acylsphingosine galactosyltransferase activity|neuron projection morphogenesis" "hsa00565,hsa00600" Ether lipid metabolism|Sphingolipid metabolism UHMK1 3914.05223 3677.185473 4150.918987 1.128830465 0.174828829 0.583377969 1 21.50536627 25.32162046 127933 U2AF homology motif kinase 1 "GO:0003723,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0007050,GO:0016740,GO:0018105,GO:0030424,GO:0030496,GO:0031175,GO:0032839,GO:0043021,GO:0045948,GO:0046777,GO:0046825,GO:0071598,GO:0106310,GO:0106311" RNA binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|Golgi apparatus|cell cycle arrest|transferase activity|peptidyl-serine phosphorylation|axon|midbody|neuron projection development|dendrite cytoplasm|ribonucleoprotein complex binding|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus|neuronal ribonucleoprotein granule|protein serine kinase activity|protein threonine kinase activity UHRF1 1579.114611 1598.55565 1559.673571 0.975676744 -0.035524854 0.916032824 1 17.24413297 17.54943933 29128 ubiquitin like with PHD and ring finger domains 1 "GO:0000122,GO:0000785,GO:0000791,GO:0000792,GO:0000987,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0006281,GO:0006511,GO:0007049,GO:0008270,GO:0008327,GO:0010216,GO:0010390,GO:0016363,GO:0016567,GO:0016574,GO:0031493,GO:0032270,GO:0035064,GO:0042393,GO:0042802,GO:0044729,GO:0045944,GO:0050678,GO:0051865,GO:0061630,GO:2000373" negative regulation of transcription by RNA polymerase II|chromatin|euchromatin|heterochromatin|cis-regulatory region sequence-specific DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|replication fork|DNA repair|ubiquitin-dependent protein catabolic process|cell cycle|zinc ion binding|methyl-CpG binding|maintenance of DNA methylation|histone monoubiquitination|nuclear matrix|protein ubiquitination|histone ubiquitination|nucleosomal histone binding|positive regulation of cellular protein metabolic process|methylated histone binding|histone binding|identical protein binding|hemi-methylated DNA-binding|positive regulation of transcription by RNA polymerase II|regulation of epithelial cell proliferation|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity UHRF1BP1 962.9146041 762.2319322 1163.597276 1.5265659 0.610289871 0.085791356 1 4.035158187 6.425279904 54887 UHRF1 binding protein 1 "GO:0005515,GO:0042802,GO:0042826" protein binding|identical protein binding|histone deacetylase binding UHRF1BP1L 680.1667271 662.7662473 697.5672069 1.052508648 0.073832087 0.849358948 1 3.958345794 4.345655885 23074 UHRF1 binding protein 1 like "GO:0005515,GO:0005769,GO:0005829,GO:0042803,GO:0062069" protein binding|early endosome|cytosol|protein homodimerization activity|GARP complex binding UHRF2 724.8856567 554.1659587 895.6053546 1.616132028 0.692545062 0.065235169 1 7.286228149 12.28274774 115426 ubiquitin like with PHD and ring finger domains 2 "GO:0000792,GO:0003677,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0007049,GO:0008134,GO:0010216,GO:0016567,GO:0030154,GO:0042393,GO:0046872,GO:0051726,GO:0051865,GO:0061630,GO:0071158" heterochromatin|DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|cell cycle|transcription factor binding|maintenance of DNA methylation|protein ubiquitination|cell differentiation|histone binding|metal ion binding|regulation of cell cycle|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of cell cycle arrest UIMC1 674.4953946 645.5119959 703.4787934 1.089799722 0.124063027 0.747214066 1 10.09663538 11.47728841 51720 ubiquitin interaction motif containing 1 "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006302,GO:0006303,GO:0010212,GO:0016579,GO:0016604,GO:0042393,GO:0045739,GO:0045892,GO:0046872,GO:0070530,GO:0070531,GO:0070537,GO:0072425" "DNA binding|protein binding|nucleus|nucleoplasm|double-strand break repair|double-strand break repair via nonhomologous end joining|response to ionizing radiation|protein deubiquitination|nuclear body|histone binding|positive regulation of DNA repair|negative regulation of transcription, DNA-templated|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|BRCA1-A complex|histone H2A K63-linked deubiquitination|signal transduction involved in G2 DNA damage checkpoint" hsa03440 Homologous recombination ULBP1 47.85683148 38.5683268 57.14533616 1.481664902 0.5672192 0.517224875 1 0.608330642 0.940168326 80329 UL16 binding protein 1 "GO:0005515,GO:0005615,GO:0005783,GO:0005829,GO:0005886,GO:0006955,GO:0009897,GO:0016032,GO:0030101,GO:0042267,GO:0046658,GO:0046703,GO:0050776" protein binding|extracellular space|endoplasmic reticulum|cytosol|plasma membrane|immune response|external side of plasma membrane|viral process|natural killer cell activation|natural killer cell mediated cytotoxicity|anchored component of plasma membrane|natural killer cell lectin-like receptor binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity ULBP2 258.8652363 251.7090802 266.0213925 1.056860532 0.079785005 0.879459351 1 9.09285088 10.02382967 80328 UL16 binding protein 2 "GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0006955,GO:0009897,GO:0009986,GO:0016032,GO:0030101,GO:0042267,GO:0046658,GO:0046703" protein binding|extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|immune response|external side of plasma membrane|cell surface|viral process|natural killer cell activation|natural killer cell mediated cytotoxicity|anchored component of plasma membrane|natural killer cell lectin-like receptor binding hsa04650 Natural killer cell mediated cytotoxicity ULBP3 161.1810445 174.5724266 147.7896625 0.846580788 -0.240280345 0.684131492 1 2.842004999 2.509626987 79465 UL16 binding protein 3 "GO:0005515,GO:0005615,GO:0005886,GO:0006955,GO:0009897,GO:0016032,GO:0030101,GO:0042267,GO:0046658,GO:0046703,GO:0050776" protein binding|extracellular space|plasma membrane|immune response|external side of plasma membrane|viral process|natural killer cell activation|natural killer cell mediated cytotoxicity|anchored component of plasma membrane|natural killer cell lectin-like receptor binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity ULK1 1377.305882 970.2979058 1784.313858 1.838934051 0.878869742 0.009127789 0.401681986 9.115593753 17.48505676 8408 unc-51 like autophagy activating kinase 1 "GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005741,GO:0005776,GO:0005789,GO:0005829,GO:0006468,GO:0006914,GO:0007165,GO:0008104,GO:0010508,GO:0016236,GO:0016241,GO:0016301,GO:0018105,GO:0018107,GO:0030424,GO:0031102,GO:0031175,GO:0031267,GO:0031333,GO:0031669,GO:0032045,GO:0034045,GO:0042594,GO:0042802,GO:0044877,GO:0046777,GO:0048675,GO:0051020,GO:0055037,GO:0075044,GO:0097629,GO:0097632,GO:0097635,GO:0106310,GO:0106311,GO:1990316,GO:2000786" protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|mitochondrial outer membrane|autophagosome|endoplasmic reticulum membrane|cytosol|protein phosphorylation|autophagy|signal transduction|protein localization|positive regulation of autophagy|macroautophagy|regulation of macroautophagy|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|axon|neuron projection regeneration|neuron projection development|small GTPase binding|negative regulation of protein-containing complex assembly|cellular response to nutrient levels|guanyl-nucleotide exchange factor complex|phagophore assembly site membrane|response to starvation|identical protein binding|protein-containing complex binding|protein autophosphorylation|axon extension|GTPase binding|recycling endosome|positive regulation by symbiont of host autophagy|extrinsic component of omegasome membrane|extrinsic component of phagophore assembly site membrane|extrinsic component of autophagosome membrane|protein serine kinase activity|protein threonine kinase activity|Atg1/ULK1 kinase complex|positive regulation of autophagosome assembly "hsa04137,hsa04140,hsa04150,hsa04152,hsa04211,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Mitophagy - animal|Autophagy - animal|mTOR signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ULK2 230.107738 138.0340117 322.1814642 2.334073032 1.222849703 0.018678119 0.589604582 0.756840504 1.842615571 9706 unc-51 like autophagy activating kinase 2 "GO:0004674,GO:0005515,GO:0005524,GO:0006914,GO:0007165,GO:0030659,GO:0034045,GO:0042594,GO:0046777,GO:0048675,GO:0075044,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|autophagy|signal transduction|cytoplasmic vesicle membrane|phagophore assembly site membrane|response to starvation|protein autophosphorylation|axon extension|positive regulation by symbiont of host autophagy|protein serine kinase activity|protein threonine kinase activity "hsa04136,hsa04140,hsa04150,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - other|Autophagy - animal|mTOR signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ULK3 642.2840276 598.8240213 685.7440339 1.145151179 0.19553807 0.613255406 1 11.06873144 13.22137443 25989 unc-51 like kinase 3 "GO:0000407,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006914,GO:0007224,GO:0045879,GO:0045880,GO:0046777,GO:0072537,GO:0090398,GO:0097542,GO:0106310,GO:0106311" phagophore assembly site|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|autophagy|smoothened signaling pathway|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|protein autophosphorylation|fibroblast activation|cellular senescence|ciliary tip|protein serine kinase activity|protein threonine kinase activity ULK4 89.14341911 99.4656849 78.82115332 0.79244569 -0.33561603 0.641682471 1 0.81316966 0.672150621 54986 unc-51 like kinase 4 "GO:0000226,GO:0005524,GO:0006468,GO:0010975,GO:0043408,GO:0046328,GO:0090036,GO:0106310,GO:0106311,GO:1900744,GO:2001222" microtubule cytoskeleton organization|ATP binding|protein phosphorylation|regulation of neuron projection development|regulation of MAPK cascade|regulation of JNK cascade|regulation of protein kinase C signaling|protein serine kinase activity|protein threonine kinase activity|regulation of p38MAPK cascade|regulation of neuron migration UMAD1 334.2622125 320.726086 347.798339 1.084409265 0.116909344 0.803452396 1 6.944696367 7.855293411 729852 UBAP1-MVB12-associated (UMA) domain containing 1 GO:0005515 protein binding UMPS 485.7215033 537.9266632 433.5163433 0.805902315 -0.311323117 0.450458999 1 4.095623542 3.442852079 7372 uridine monophosphate synthetase "GO:0004588,GO:0004590,GO:0005634,GO:0005737,GO:0005829,GO:0006207,GO:0006222,GO:0007565,GO:0007595,GO:0019856,GO:0035690,GO:0044205,GO:0046134" orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity|nucleus|cytoplasm|cytosol|'de novo' pyrimidine nucleobase biosynthetic process|UMP biosynthetic process|female pregnancy|lactation|pyrimidine nucleobase biosynthetic process|cellular response to drug|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes UNC119 569.8225557 595.7791534 543.8659579 0.912865035 -0.131526518 0.742618638 1 17.91811897 17.06140996 9094 unc-119 lipid binding chaperone "GO:0000281,GO:0000922,GO:0005515,GO:0005813,GO:0005829,GO:0006897,GO:0007268,GO:0007399,GO:0007601,GO:0007602,GO:0008289,GO:0042953,GO:0045171,GO:0045202,GO:0051233,GO:0061098,GO:1900186,GO:2001287" mitotic cytokinesis|spindle pole|protein binding|centrosome|cytosol|endocytosis|chemical synaptic transmission|nervous system development|visual perception|phototransduction|lipid binding|lipoprotein transport|intercellular bridge|synapse|spindle midzone|positive regulation of protein tyrosine kinase activity|negative regulation of clathrin-dependent endocytosis|negative regulation of caveolin-mediated endocytosis UNC119B 2033.871792 2175.05064 1892.692944 0.870183392 -0.200608612 0.533500859 1 25.14463406 22.8229637 84747 unc-119 lipid binding chaperone B "GO:0005515,GO:0005829,GO:0005929,GO:0007399,GO:0008289,GO:0035869,GO:0042953,GO:0060271" protein binding|cytosol|cilium|nervous system development|lipid binding|ciliary transition zone|lipoprotein transport|cilium assembly UNC13A 2.970639026 1.014955968 4.926322083 4.853729853 2.279093814 0.420006506 1 0.005143995 0.026043062 23025 unc-13 homolog A "GO:0005509,GO:0005516,GO:0005543,GO:0005886,GO:0007269,GO:0007528,GO:0016081,GO:0016082,GO:0016188,GO:0017075,GO:0019992,GO:0030154,GO:0030672,GO:0031594,GO:0035249,GO:0035556,GO:0042734,GO:0043005,GO:0043195,GO:0048786,GO:0051966,GO:0061789,GO:0098831,GO:0099011,GO:0099525,GO:1903861" "calcium ion binding|calmodulin binding|phospholipid binding|plasma membrane|neurotransmitter secretion|neuromuscular junction development|synaptic vesicle docking|synaptic vesicle priming|synaptic vesicle maturation|syntaxin-1 binding|diacylglycerol binding|cell differentiation|synaptic vesicle membrane|neuromuscular junction|synaptic transmission, glutamatergic|intracellular signal transduction|presynaptic membrane|neuron projection|terminal bouton|presynaptic active zone|regulation of synaptic transmission, glutamatergic|dense core granule priming|presynaptic active zone cytoplasmic component|neuronal dense core vesicle exocytosis|presynaptic dense core vesicle exocytosis|positive regulation of dendrite extension" hsa04721 Synaptic vesicle cycle UNC13B 1284.432959 1390.489677 1178.376242 0.847454147 -0.238792785 0.481088707 1 3.270790803 2.891245079 10497 unc-13 homolog B "GO:0005509,GO:0005515,GO:0005516,GO:0005543,GO:0005794,GO:0005829,GO:0005886,GO:0007268,GO:0007269,GO:0007528,GO:0010808,GO:0014047,GO:0016020,GO:0016081,GO:0016082,GO:0016188,GO:0017075,GO:0019992,GO:0030672,GO:0030742,GO:0031267,GO:0031594,GO:0035249,GO:0035556,GO:0042734,GO:0043065,GO:0043195,GO:0048786,GO:0050714,GO:0060478,GO:0061789,GO:0071333,GO:0097151,GO:0098831,GO:0099011,GO:0099525" "calcium ion binding|protein binding|calmodulin binding|phospholipid binding|Golgi apparatus|cytosol|plasma membrane|chemical synaptic transmission|neurotransmitter secretion|neuromuscular junction development|positive regulation of synaptic vesicle priming|glutamate secretion|membrane|synaptic vesicle docking|synaptic vesicle priming|synaptic vesicle maturation|syntaxin-1 binding|diacylglycerol binding|synaptic vesicle membrane|GTP-dependent protein binding|small GTPase binding|neuromuscular junction|synaptic transmission, glutamatergic|intracellular signal transduction|presynaptic membrane|positive regulation of apoptotic process|terminal bouton|presynaptic active zone|positive regulation of protein secretion|acrosomal vesicle exocytosis|dense core granule priming|cellular response to glucose stimulus|positive regulation of inhibitory postsynaptic potential|presynaptic active zone cytoplasmic component|neuronal dense core vesicle exocytosis|presynaptic dense core vesicle exocytosis" hsa04721 Synaptic vesicle cycle UNC13D 43.97515692 42.62815067 45.32216316 1.063197968 0.088410252 0.947493381 1 0.529158198 0.586834444 201294 unc-13 homolog D "GO:0002432,GO:0002467,GO:0005515,GO:0005576,GO:0005764,GO:0005770,GO:0005829,GO:0006909,GO:0016020,GO:0031267,GO:0033093,GO:0035578,GO:0043231,GO:0043304,GO:0043312,GO:0043320,GO:0045921,GO:0046872,GO:0051607,GO:0055037,GO:0070382,GO:1900026,GO:1903307" granuloma formation|germinal center formation|protein binding|extracellular region|lysosome|late endosome|cytosol|phagocytosis|membrane|small GTPase binding|Weibel-Palade body|azurophil granule lumen|intracellular membrane-bounded organelle|regulation of mast cell degranulation|neutrophil degranulation|natural killer cell degranulation|positive regulation of exocytosis|metal ion binding|defense response to virus|recycling endosome|exocytic vesicle|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of regulated secretory pathway UNC45A 3406.62398 2968.746207 3844.501753 1.294991719 0.372942872 0.241250956 1 35.74810326 48.28763381 55898 unc-45 myosin chaperone A "GO:0005515,GO:0005794,GO:0005829,GO:0007517,GO:0016607,GO:0030154,GO:0045296,GO:0048471,GO:0051879,GO:0061077" protein binding|Golgi apparatus|cytosol|muscle organ development|nuclear speck|cell differentiation|cadherin binding|perinuclear region of cytoplasm|Hsp90 protein binding|chaperone-mediated protein folding UNC50 576.5857946 586.6445497 566.5270395 0.965707497 -0.050341818 0.902785476 1 23.43176411 23.60296264 25972 unc-50 inner nuclear membrane RNA binding protein "GO:0003723,GO:0005515,GO:0005637,GO:0006810,GO:0015031,GO:0030173" RNA binding|protein binding|nuclear inner membrane|transport|protein transport|integral component of Golgi membrane UNC5A 3.522654337 5.074779842 1.970528833 0.388298388 -1.364762376 0.607675962 1 0.036949353 0.014965401 90249 unc-5 netrin receptor A "GO:0005042,GO:0005886,GO:0006915,GO:0007411,GO:0016021,GO:0031175,GO:0031226,GO:0032589,GO:0032809,GO:0033564,GO:0038007,GO:0045121" netrin receptor activity|plasma membrane|apoptotic process|axon guidance|integral component of membrane|neuron projection development|intrinsic component of plasma membrane|neuron projection membrane|neuronal cell body membrane|anterior/posterior axon guidance|netrin-activated signaling pathway|membrane raft hsa04360 Axon guidance UNC5B 2.492852593 2.029911937 2.95579325 1.456118956 0.542128219 1 1 0.021106113 0.032056865 219699 unc-5 netrin receptor B "GO:0001525,GO:0005042,GO:0005515,GO:0005886,GO:0006915,GO:0007411,GO:0014068,GO:0016021,GO:0033564,GO:0038007,GO:0043524,GO:0045121,GO:2001240" angiogenesis|netrin receptor activity|protein binding|plasma membrane|apoptotic process|axon guidance|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|anterior/posterior axon guidance|netrin-activated signaling pathway|negative regulation of neuron apoptotic process|membrane raft|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa04360 Axon guidance UNC79 3.985594994 3.044867905 4.926322083 1.617909951 0.694131313 0.84600796 1 0.009006647 0.015199645 57578 "unc-79 homolog, NALCN channel complex subunit" "GO:0005886,GO:0016021,GO:0034220" plasma membrane|integral component of membrane|ion transmembrane transport UNC80 2.522544145 4.059823873 0.985264417 0.242686493 -2.042834281 0.524611851 1 0.012297593 0.003113018 285175 "unc-80 homolog, NALCN channel complex subunit" "GO:0005261,GO:0005886,GO:0030424,GO:0034220,GO:0034703,GO:0055080,GO:0098655" cation channel activity|plasma membrane|axon|ion transmembrane transport|cation channel complex|cation homeostasis|cation transmembrane transport UNC93B1 687.6992248 739.9029009 635.4955487 0.858890468 -0.219453935 0.564075904 1 16.32831011 14.62833686 81622 "unc-93 homolog B1, TLR signaling regulator" "GO:0000139,GO:0002224,GO:0002250,GO:0005515,GO:0005764,GO:0005768,GO:0005783,GO:0005789,GO:0006886,GO:0016021,GO:0032009,GO:0034138,GO:0034154,GO:0034162,GO:0035325,GO:0045087,GO:0051607" Golgi membrane|toll-like receptor signaling pathway|adaptive immune response|protein binding|lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|intracellular protein transport|integral component of membrane|early phagosome|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway|Toll-like receptor binding|innate immune response|defense response to virus UNG 1154.984258 1095.13749 1214.831026 1.109295442 0.149643654 0.664913555 1 24.03156432 27.8064278 7374 uracil DNA glycosylase "GO:0003684,GO:0004844,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006281,GO:0006284,GO:0016032,GO:0016446,GO:0043024,GO:0043066,GO:0045008,GO:0045190,GO:0097510" "damaged DNA binding|uracil DNA N-glycosylase activity|protein binding|nucleus|nucleoplasm|mitochondrion|DNA repair|base-excision repair|viral process|somatic hypermutation of immunoglobulin genes|ribosomal small subunit binding|negative regulation of apoptotic process|depyrimidination|isotype switching|base-excision repair, AP site formation via deaminated base removal" "hsa03410,hsa05340" Base excision repair|Primary immunodeficiency UNK 694.1858372 644.4970399 743.8746345 1.154194028 0.206885771 0.58604497 1 3.852413717 4.637967202 85451 unk zinc finger "GO:0001701,GO:0001764,GO:0003723,GO:0005737,GO:0005844,GO:0046872,GO:0048667,GO:1905538,GO:1990715,GO:2000766" in utero embryonic development|neuron migration|RNA binding|cytoplasm|polysome|metal ion binding|cell morphogenesis involved in neuron differentiation|polysome binding|mRNA CDS binding|negative regulation of cytoplasmic translation UNKL 275.0424271 313.6213942 236.46346 0.753977453 -0.407406714 0.403152316 1 2.432437554 1.913004485 64718 unk like zinc finger "GO:0000209,GO:0005515,GO:0005634,GO:0005829,GO:0016740,GO:0046872" protein polyubiquitination|protein binding|nucleus|cytosol|transferase activity|metal ion binding UPF1 2320.475612 2403.415733 2237.53549 0.930981461 -0.103175656 0.747737268 1 20.63477338 20.03810583 5976 UPF1 RNA helicase and ATPase "GO:0000184,GO:0000294,GO:0000781,GO:0000785,GO:0000932,GO:0000956,GO:0003682,GO:0003723,GO:0003724,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006260,GO:0006281,GO:0006406,GO:0006449,GO:0008270,GO:0009048,GO:0016032,GO:0032201,GO:0032204,GO:0035145,GO:0042162,GO:0044530,GO:0044770,GO:0061014,GO:0061158,GO:0071044,GO:0071222,GO:0071347" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|chromosome, telomeric region|chromatin|P-body|nuclear-transcribed mRNA catabolic process|chromatin binding|RNA binding|RNA helicase activity|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA replication|DNA repair|mRNA export from nucleus|regulation of translational termination|zinc ion binding|dosage compensation by inactivation of X chromosome|viral process|telomere maintenance via semi-conservative replication|regulation of telomere maintenance|exon-exon junction complex|telomeric DNA binding|supraspliceosomal complex|cell cycle phase transition|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|histone mRNA catabolic process|cellular response to lipopolysaccharide|cellular response to interleukin-1" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway UPF2 1284.156333 1304.218419 1264.094246 0.969235082 -0.04508147 0.896262311 1 10.85166123 10.9708754 26019 UPF2 regulator of nonsense mediated mRNA decay "GO:0000184,GO:0001889,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006406,GO:0031100,GO:0035145,GO:0036464,GO:0042162,GO:0048471" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|liver development|RNA binding|protein binding|nucleus|cytoplasm|cytosol|polysome|mRNA export from nucleus|animal organ regeneration|exon-exon junction complex|cytoplasmic ribonucleoprotein granule|telomeric DNA binding|perinuclear region of cytoplasm" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway UPF3A 580.6928774 564.3155184 597.0702364 1.05804327 0.081398629 0.840080911 1 5.644991156 6.229922221 65110 UPF3A regulator of nonsense mediated mRNA decay "GO:0000184,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006913,GO:0017056,GO:0035145,GO:0042162,GO:0043231,GO:0045727,GO:0051028" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|nucleocytoplasmic transport|structural constituent of nuclear pore|exon-exon junction complex|telomeric DNA binding|intracellular membrane-bounded organelle|positive regulation of translation|mRNA transport" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway UPF3B 570.5109046 575.4800341 565.5417751 0.982730489 -0.02513228 0.954090661 1 9.401946308 9.637582893 65109 UPF3B regulator of nonsense mediated mRNA decay "GO:0000184,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0017056,GO:0031124,GO:0034451,GO:0035145,GO:0045727" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|structural constituent of nuclear pore|mRNA 3'-end processing|centriolar satellite|exon-exon junction complex|positive regulation of translation" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway UPK1A 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.113141466 0.038187574 11045 uroplakin 1A "GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0009986,GO:0016021,GO:0030855,GO:0032991,GO:0070062,GO:0120001" protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cell surface|integral component of membrane|epithelial cell differentiation|protein-containing complex|extracellular exosome|apical plasma membrane urothelial plaque UPK3BL2 18.95755633 16.23929549 21.67581716 1.334775709 0.416597337 0.745397435 1 0.442898777 0.616635757 107983993 uroplakin 3B like 2 GO:0016021 integral component of membrane UPP1 509.896854 641.452172 378.341536 0.589820337 -0.761652529 0.06160782 1 13.52509975 8.321012016 7378 uridine phosphorylase 1 "GO:0004850,GO:0005654,GO:0005829,GO:0006139,GO:0006218,GO:0009032,GO:0042149,GO:0042802,GO:0043097,GO:0044206,GO:0046050,GO:0046074,GO:0046135" uridine phosphorylase activity|nucleoplasm|cytosol|nucleobase-containing compound metabolic process|uridine catabolic process|thymidine phosphorylase activity|cellular response to glucose starvation|identical protein binding|pyrimidine nucleoside salvage|UMP salvage|UMP catabolic process|dTMP catabolic process|pyrimidine nucleoside catabolic process "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes UPRT 303.8053687 360.3093688 247.3013686 0.686358419 -0.542965942 0.249322862 1 4.136083054 2.961120941 139596 uracil phosphoribosyltransferase homolog "GO:0005515,GO:0005525,GO:0005654,GO:0005829,GO:0006222,GO:0007565,GO:0007595,GO:0009116,GO:0016301,GO:0016310,GO:0032868,GO:0043231" protein binding|GTP binding|nucleoplasm|cytosol|UMP biosynthetic process|female pregnancy|lactation|nucleoside metabolic process|kinase activity|phosphorylation|response to insulin|intracellular membrane-bounded organelle hsa00240 Pyrimidine metabolism UQCC1 1750.447937 1759.933649 1740.962224 0.989220375 -0.01563614 0.963623328 1 34.57503129 35.67562287 55245 ubiquinol-cytochrome c reductase complex assembly factor 1 "GO:0005515,GO:0005743,GO:0031410,GO:0034551,GO:0070131" protein binding|mitochondrial inner membrane|cytoplasmic vesicle|mitochondrial respiratory chain complex III assembly|positive regulation of mitochondrial translation UQCC2 466.8908779 429.3263746 504.4553813 1.174992759 0.232651866 0.57787171 1 16.93447531 20.75500609 84300 ubiquinol-cytochrome c reductase complex assembly factor 2 "GO:0002082,GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0016604,GO:0034551,GO:0042645,GO:0050796,GO:0070131,GO:1903364,GO:2001014" regulation of oxidative phosphorylation|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nuclear body|mitochondrial respiratory chain complex III assembly|mitochondrial nucleoid|regulation of insulin secretion|positive regulation of mitochondrial translation|positive regulation of cellular protein catabolic process|regulation of skeletal muscle cell differentiation UQCC3 269.2995873 257.798816 280.8003587 1.089222841 0.123299141 0.807235008 1 6.775610051 7.698056127 790955 ubiquinol-cytochrome c reductase complex assembly factor 3 "GO:0005654,GO:0005739,GO:0005750,GO:0005829,GO:0006122,GO:0006754,GO:0031305,GO:0034551,GO:0042407,GO:0070300,GO:1901612" "nucleoplasm|mitochondrion|mitochondrial respiratory chain complex III|cytosol|mitochondrial electron transport, ubiquinol to cytochrome c|ATP biosynthetic process|integral component of mitochondrial inner membrane|mitochondrial respiratory chain complex III assembly|cristae formation|phosphatidic acid binding|cardiolipin binding" UQCR10 2009.132302 2032.956805 1985.307799 0.976561723 -0.034216864 0.91692669 1 112.4040287 114.4978956 29796 "ubiquinol-cytochrome c reductase, complex III subunit X" "GO:0005743,GO:0005750,GO:0006122,GO:0008121,GO:0009060,GO:0016021" "mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration|integral component of membrane" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCR11 1485.170317 1608.70521 1361.635424 0.846416991 -0.240559506 0.468992541 1 62.72151171 55.3753928 10975 "ubiquinol-cytochrome c reductase, complex III subunit XI" "GO:0005743,GO:0006091,GO:0006122,GO:0008121,GO:0009055,GO:0016021,GO:0070469" "mitochondrial inner membrane|generation of precursor metabolites and energy|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|electron transfer activity|integral component of membrane|respirasome" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRB 4008.008402 4072.003345 3944.013459 0.968568325 -0.046074271 0.885748387 1 23.67768132 23.92133224 7381 ubiquinol-cytochrome c reductase binding protein "GO:0005515,GO:0005743,GO:0005746,GO:0005750,GO:0006119,GO:0006122,GO:0009060,GO:0055114" "protein binding|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial respiratory chain complex III|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|oxidation-reduction process" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRC1 4270.085769 4475.955821 4064.215718 0.908010687 -0.139218818 0.663033396 1 142.1262521 134.6111992 7384 ubiquinol-cytochrome c reductase core protein 1 "GO:0005515,GO:0005739,GO:0005743,GO:0005746,GO:0005750,GO:0006119,GO:0006122,GO:0008121,GO:0009060,GO:0014823,GO:0031625,GO:0043279,GO:0044877,GO:0046872,GO:0055114" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial respiratory chain complex III|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration|response to activity|ubiquitin protein ligase binding|response to alkaloid|protein-containing complex binding|metal ion binding|oxidation-reduction process" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRC2 1910.75704 2009.612817 1811.901262 0.901617091 -0.149413232 0.644727889 1 53.17648888 50.01010008 7385 ubiquinol-cytochrome c reductase core protein 2 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005750,GO:0005751,GO:0006119,GO:0006122,GO:0006508,GO:0009060,GO:0042493,GO:0044877,GO:0046872" "protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial respiratory chain complex IV|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|proteolysis|aerobic respiration|response to drug|protein-containing complex binding|metal ion binding" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRFS1 1134.67153 1222.006986 1047.336075 0.857062265 -0.222528076 0.5196632 1 20.05519859 17.92896712 7386 "ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1" "GO:0005515,GO:0005739,GO:0005743,GO:0005750,GO:0005751,GO:0006122,GO:0008121,GO:0016021,GO:0016491,GO:0022904,GO:0034551,GO:0046872,GO:0051537" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial respiratory chain complex IV|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|integral component of membrane|oxidoreductase activity|respiratory electron transport chain|mitochondrial respiratory chain complex III assembly|metal ion binding|2 iron, 2 sulfur cluster binding" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRH 2721.751888 2893.639466 2549.86431 0.881196272 -0.182464703 0.567051532 1 213.9454464 196.6489484 7388 ubiquinol-cytochrome c reductase hinge protein "GO:0005515,GO:0005739,GO:0005743,GO:0005746,GO:0005750,GO:0006119,GO:0006122,GO:0008121,GO:0009060,GO:0055114" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial respiratory chain complex III|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration|oxidation-reduction process" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRHL 157.7623106 176.6023385 138.9222827 0.786638976 -0.346226425 0.556333762 1 16.62506585 13.64126874 440567 ubiquinol-cytochrome c reductase hinge protein like "GO:0005750,GO:0006122,GO:0008121,GO:0009060" "mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRQ 1515.535364 1596.525738 1434.54499 0.898541725 -0.154342596 0.641994901 1 51.40393925 48.17820112 27089 ubiquinol-cytochrome c reductase complex III subunit VII "GO:0005739,GO:0005743,GO:0005750,GO:0006122,GO:0008121,GO:0016021,GO:0021539,GO:0021548,GO:0021680,GO:0021766,GO:0021794,GO:0021854,GO:0021860,GO:0030901" "mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|integral component of membrane|subthalamus development|pons development|cerebellar Purkinje cell layer development|hippocampus development|thalamus development|hypothalamus development|pyramidal neuron development|midbrain development" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases URB1 1255.886024 1257.530445 1254.241602 0.997384682 -0.003778049 0.993797429 1 5.887361872 6.124904964 9875 URB1 ribosome biogenesis homolog "GO:0000463,GO:0000466,GO:0001650,GO:0003723,GO:0005730,GO:0008150" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|fibrillar center|RNA binding|nucleolus|biological_process" URB2 562.5342714 636.3773922 488.6911506 0.767926637 -0.380959604 0.337567184 1 5.722704174 4.583919247 9816 URB2 ribosome biogenesis homolog "GO:0005730,GO:0016235,GO:0030496,GO:0042254" nucleolus|aggresome|midbody|ribosome biogenesis URGCP 816.9942716 721.6336935 912.3548497 1.264290814 0.338328352 0.355397496 1 8.523367725 11.24020256 55665 upregulator of cell proliferation "GO:0005525,GO:0005634,GO:0005829,GO:0007049" GTP binding|nucleus|cytosol|cell cycle URI1 809.1512504 791.6656553 826.6368455 1.044174191 0.062362405 0.867961275 1 9.532827535 10.38270753 8725 URI1 prefoldin like chaperone "GO:0000122,GO:0000993,GO:0001558,GO:0003682,GO:0003714,GO:0004864,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006357,GO:0009615,GO:0010923,GO:0019212,GO:0030425,GO:0032515,GO:0051219,GO:0071363,GO:0071383,GO:2001243" negative regulation of transcription by RNA polymerase II|RNA polymerase II complex binding|regulation of cell growth|chromatin binding|transcription corepressor activity|protein phosphatase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|response to virus|negative regulation of phosphatase activity|phosphatase inhibitor activity|dendrite|negative regulation of phosphoprotein phosphatase activity|phosphoprotein binding|cellular response to growth factor stimulus|cellular response to steroid hormone stimulus|negative regulation of intrinsic apoptotic signaling pathway URM1 1144.163917 1062.658899 1225.668934 1.153398269 0.205890762 0.550992861 1 20.30940543 24.43387987 81605 ubiquitin related modifier 1 "GO:0002098,GO:0005515,GO:0005634,GO:0005829,GO:0006400,GO:0031386,GO:0032447,GO:0034227,GO:0097163" tRNA wobble uridine modification|protein binding|nucleus|cytosol|tRNA modification|protein tag|protein urmylation|tRNA thio-modification|sulfur carrier activity hsa04122 Sulfur relay system UROD 2254.183547 2350.638023 2157.729072 0.917933366 -0.123538665 0.700239648 1 99.79172112 95.5479996 7389 uroporphyrinogen decarboxylase "GO:0004853,GO:0005515,GO:0005654,GO:0005829,GO:0006782,GO:0006783" uroporphyrinogen decarboxylase activity|protein binding|nucleoplasm|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process hsa00860 Porphyrin and chlorophyll metabolism UROS 590.3443617 651.6017317 529.0869917 0.811979106 -0.30048549 0.444680418 1 5.642217302 4.77870908 7390 uroporphyrinogen III synthase "GO:0004852,GO:0005739,GO:0005829,GO:0006780,GO:0006782,GO:0006783" uroporphyrinogen-III synthase activity|mitochondrion|cytosol|uroporphyrinogen III biosynthetic process|protoporphyrinogen IX biosynthetic process|heme biosynthetic process hsa00860 Porphyrin and chlorophyll metabolism USB1 1439.508185 1383.384985 1495.631384 1.081138946 0.112551947 0.736885971 1 14.38676986 16.22410462 79650 U6 snRNA biogenesis phosphodiesterase 1 "GO:0000175,GO:0005634,GO:0005654,GO:0008380,GO:0034477,GO:0045171,GO:0090503,GO:1990838" "3'-5'-exoribonuclease activity|nucleus|nucleoplasm|RNA splicing|U6 snRNA 3'-end processing|intercellular bridge|RNA phosphodiester bond hydrolysis, exonucleolytic|poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends" USE1 219.365585 245.6193443 193.1118256 0.786224009 -0.346987674 0.509664524 1 14.53242208 11.91791365 55850 unconventional SNARE in the ER 1 "GO:0005484,GO:0005515,GO:0005764,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006888,GO:0006890,GO:0007041,GO:0015031,GO:0016021,GO:0030137,GO:0030163,GO:0031201,GO:0032940,GO:0061025" "SNAP receptor activity|protein binding|lysosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|lysosomal transport|protein transport|integral component of membrane|COPI-coated vesicle|protein catabolic process|SNARE complex|secretion by cell|membrane fusion" hsa04130 SNARE interactions in vesicular transport USF1 906.1119585 954.0586103 858.1653068 0.899489085 -0.152822319 0.671662176 1 25.70196962 24.11449845 7391 upstream transcription factor 1 "GO:0000430,GO:0000432,GO:0000785,GO:0000978,GO:0000981,GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006006,GO:0006357,GO:0009411,GO:0019086,GO:0019899,GO:0019901,GO:0032869,GO:0042593,GO:0042802,GO:0042803,GO:0042826,GO:0043425,GO:0043565,GO:0044877,GO:0045944,GO:0045990,GO:0046982,GO:0051918,GO:0055088,GO:1990837" "regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter by glucose|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|response to hypoxia|protein binding|nucleus|nucleoplasm|transcription regulator complex|glucose metabolic process|regulation of transcription by RNA polymerase II|response to UV|late viral transcription|enzyme binding|protein kinase binding|cellular response to insulin stimulus|glucose homeostasis|identical protein binding|protein homodimerization activity|histone deacetylase binding|bHLH transcription factor binding|sequence-specific DNA binding|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|carbon catabolite regulation of transcription|protein heterodimerization activity|negative regulation of fibrinolysis|lipid homeostasis|sequence-specific double-stranded DNA binding" bHLH USF2 1266.973589 1308.278243 1225.668934 0.936856468 -0.094100059 0.783178257 1 15.26720684 14.91930453 7392 "upstream transcription factor 2, c-fos interacting" "GO:0000430,GO:0000432,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0019086,GO:0042803,GO:0043231,GO:0043425,GO:0043565,GO:0045944,GO:0046982,GO:0055088,GO:1990837" "regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter by glucose|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|late viral transcription|protein homodimerization activity|intracellular membrane-bounded organelle|bHLH transcription factor binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|lipid homeostasis|sequence-specific double-stranded DNA binding" bHLH USF3 546.0656083 487.1788648 604.9523518 1.241745887 0.312369969 0.435495098 1 1.80048824 2.332055861 205717 upstream transcription factor family member 3 "GO:0003677,GO:0005634,GO:0010719,GO:0046983" DNA binding|nucleus|negative regulation of epithelial to mesenchymal transition|protein dimerization activity USO1 1771.40027 1845.189951 1697.61059 0.920019421 -0.120263779 0.712762446 1 22.19243922 21.2969771 8615 USO1 vesicle transport factor "GO:0000139,GO:0001650,GO:0003723,GO:0005515,GO:0005783,GO:0005794,GO:0005795,GO:0005829,GO:0006886,GO:0006888,GO:0007030,GO:0007264,GO:0012507,GO:0016020,GO:0030133,GO:0032252,GO:0045056,GO:0045296,GO:0048208,GO:0048211,GO:0048280,GO:0048471,GO:0061025,GO:1900076" Golgi membrane|fibrillar center|RNA binding|protein binding|endoplasmic reticulum|Golgi apparatus|Golgi stack|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|small GTPase mediated signal transduction|ER to Golgi transport vesicle membrane|membrane|transport vesicle|secretory granule localization|transcytosis|cadherin binding|COPII vesicle coating|Golgi vesicle docking|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|membrane fusion|regulation of cellular response to insulin stimulus USP1 1960.297133 1725.425146 2195.16912 1.272248248 0.347380205 0.281886214 1 23.77869299 31.55555122 7398 ubiquitin specific peptidase 1 "GO:0001501,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006282,GO:0006511,GO:0008233,GO:0009411,GO:0016579,GO:0018215,GO:0035520,GO:0036297,GO:0042769" "skeletal system development|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of DNA repair|ubiquitin-dependent protein catabolic process|peptidase activity|response to UV|protein deubiquitination|protein phosphopantetheinylation|monoubiquitinated protein deubiquitination|interstrand cross-link repair|DNA damage response, detection of DNA damage" hsa03460 Fanconi anemia pathway USP10 1996.371124 2002.508126 1990.234121 0.993870684 -0.008869944 0.979769662 1 21.34707896 22.13014538 9100 ubiquitin specific peptidase 10 "GO:0002039,GO:0003723,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0006511,GO:0006914,GO:0006974,GO:0010506,GO:0016579,GO:0018215,GO:0019985,GO:0030330,GO:0032991,GO:0043124,GO:0044325,GO:0045111,GO:0071347" "p53 binding|RNA binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|early endosome|cytosol|ubiquitin-dependent protein catabolic process|autophagy|cellular response to DNA damage stimulus|regulation of autophagy|protein deubiquitination|protein phosphopantetheinylation|translesion synthesis|DNA damage response, signal transduction by p53 class mediator|protein-containing complex|negative regulation of I-kappaB kinase/NF-kappaB signaling|ion channel binding|intermediate filament cytoskeleton|cellular response to interleukin-1" USP11 2485.896113 2396.311041 2575.481185 1.074769152 0.104026818 0.745181236 1 37.97393635 42.57128314 8237 ubiquitin specific peptidase 11 "GO:0001226,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006511,GO:0016032,GO:0016579,GO:0018215" RNA polymerase II transcription corepressor binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|chromosome|cytosol|ubiquitin-dependent protein catabolic process|viral process|protein deubiquitination|protein phosphopantetheinylation USP12 857.0053603 863.7275291 850.2831915 0.984434515 -0.022632854 0.953643884 1 9.727541094 9.988627925 219333 ubiquitin specific peptidase 12 "GO:0004197,GO:0004843,GO:0005515,GO:0005575,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0016579,GO:0018215,GO:0046872" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|cellular_component|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|metal ion binding USP13 813.9412389 816.0245986 811.8578792 0.99489388 -0.007385445 0.987694956 1 11.75782849 12.20168503 8975 ubiquitin specific peptidase 13 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006511,GO:0006914,GO:0008270,GO:0008283,GO:0010506,GO:0016579,GO:0018215,GO:0030318,GO:0031625,GO:0035523,GO:0043130,GO:0044313,GO:0044389,GO:0050821,GO:0051087,GO:0070536,GO:0070628,GO:0071108,GO:1904288,GO:1904294,GO:1904378,GO:1990380" "cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|autophagy|zinc ion binding|cell population proliferation|regulation of autophagy|protein deubiquitination|protein phosphopantetheinylation|melanocyte differentiation|ubiquitin protein ligase binding|protein K29-linked deubiquitination|ubiquitin binding|protein K6-linked deubiquitination|ubiquitin-like protein ligase binding|protein stabilization|chaperone binding|protein K63-linked deubiquitination|proteasome binding|protein K48-linked deubiquitination|BAT3 complex binding|positive regulation of ERAD pathway|maintenance of unfolded protein involved in ERAD pathway|Lys48-specific deubiquitinase activity" USP14 2774.267818 2913.938585 2634.59705 0.904136094 -0.145388146 0.64842088 1 29.68236315 27.99292051 9097 ubiquitin specific peptidase 14 "GO:0000502,GO:0004197,GO:0004843,GO:0004866,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006511,GO:0009986,GO:0010951,GO:0016579,GO:0018215,GO:0031410,GO:0045087,GO:0050920,GO:0061136,GO:0070062,GO:0070628,GO:1903070" proteasome complex|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|endopeptidase inhibitor activity|protein binding|nucleus|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|cell surface|negative regulation of endopeptidase activity|protein deubiquitination|protein phosphopantetheinylation|cytoplasmic vesicle|innate immune response|regulation of chemotaxis|regulation of proteasomal protein catabolic process|extracellular exosome|proteasome binding|negative regulation of ER-associated ubiquitin-dependent protein catabolic process USP15 1113.048415 1124.571213 1101.525618 0.979507216 -0.029871974 0.933891507 1 3.076849694 3.143618606 9958 ubiquitin specific peptidase 15 "GO:0004197,GO:0004843,GO:0005160,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006511,GO:0007179,GO:0016032,GO:0016579,GO:0018215,GO:0030509,GO:0035520,GO:0035616,GO:0042802,GO:0046332,GO:0060389,GO:0061649,GO:0071108,GO:1900246,GO:1990380" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|transforming growth factor beta receptor binding|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|transforming growth factor beta receptor signaling pathway|viral process|protein deubiquitination|protein phosphopantetheinylation|BMP signaling pathway|monoubiquitinated protein deubiquitination|histone H2B conserved C-terminal lysine deubiquitination|identical protein binding|SMAD binding|pathway-restricted SMAD protein phosphorylation|ubiquitin modification-dependent histone binding|protein K48-linked deubiquitination|positive regulation of RIG-I signaling pathway|Lys48-specific deubiquitinase activity hsa04137 Mitophagy - animal USP16 621.0805537 664.7961593 577.3649481 0.868484181 -0.203428523 0.601683819 1 10.36305947 9.387843316 10600 ubiquitin specific peptidase 16 "GO:0000278,GO:0003713,GO:0004197,GO:0004843,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006511,GO:0006974,GO:0008270,GO:0016578,GO:0016579,GO:0018215,GO:0035522,GO:0042393,GO:0043130,GO:0045893,GO:0045901,GO:0045944,GO:0051289,GO:0051301,GO:0051726,GO:0070537,GO:0140014" "mitotic cell cycle|transcription coactivator activity|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|zinc ion binding|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|monoubiquitinated histone H2A deubiquitination|histone binding|ubiquitin binding|positive regulation of transcription, DNA-templated|positive regulation of translational elongation|positive regulation of transcription by RNA polymerase II|protein homotetramerization|cell division|regulation of cell cycle|histone H2A K63-linked deubiquitination|mitotic nuclear division" USP18 77.49839542 111.6451565 43.35163433 0.388298388 -1.364762376 0.066689032 1 2.602132221 1.053927843 11274 ubiquitin specific peptidase 18 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0016579,GO:0018215,GO:0043231,GO:0050727,GO:0060338" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|intracellular membrane-bounded organelle|regulation of inflammatory response|regulation of type I interferon-mediated signaling pathway USP19 1653.323925 1586.376179 1720.271671 1.084403368 0.116901499 0.722465567 1 15.19946217 17.19234068 10869 ubiquitin specific peptidase 19 "GO:0004843,GO:0005515,GO:0005789,GO:0005829,GO:0008234,GO:0016021,GO:0016579,GO:0018215,GO:0030433,GO:0031625,GO:0031647,GO:0034976,GO:0046872,GO:0048642,GO:0050821,GO:0051879,GO:0071108,GO:0090068,GO:1900037,GO:1901799,GO:1904292,GO:1990380" thiol-dependent ubiquitin-specific protease activity|protein binding|endoplasmic reticulum membrane|cytosol|cysteine-type peptidase activity|integral component of membrane|protein deubiquitination|protein phosphopantetheinylation|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|regulation of protein stability|response to endoplasmic reticulum stress|metal ion binding|negative regulation of skeletal muscle tissue development|protein stabilization|Hsp90 protein binding|protein K48-linked deubiquitination|positive regulation of cell cycle process|regulation of cellular response to hypoxia|negative regulation of proteasomal protein catabolic process|regulation of ERAD pathway|Lys48-specific deubiquitinase activity USP20 776.088231 754.1122845 798.0641774 1.058282956 0.081725416 0.827913119 1 7.081981617 7.817583461 10868 ubiquitin specific peptidase 20 "GO:0001664,GO:0004197,GO:0004843,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0006511,GO:0006897,GO:0008270,GO:0008277,GO:0016579,GO:0018215,GO:0048471,GO:0070536,GO:0071108" G protein-coupled receptor binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|cytoplasm|centrosome|cytosol|ubiquitin-dependent protein catabolic process|endocytosis|zinc ion binding|regulation of G protein-coupled receptor signaling pathway|protein deubiquitination|protein phosphopantetheinylation|perinuclear region of cytoplasm|protein K63-linked deubiquitination|protein K48-linked deubiquitination USP21 645.6609458 560.2556945 731.0661971 1.304879547 0.383916639 0.318321109 1 11.20212178 15.24707875 27005 ubiquitin specific peptidase 21 "GO:0003713,GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006511,GO:0008234,GO:0016578,GO:0016579,GO:0018215,GO:0019784,GO:0031175,GO:0045893,GO:0046872" "transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|NEDD8-specific protease activity|neuron projection development|positive regulation of transcription, DNA-templated|metal ion binding" hsa04217 Necroptosis USP22 8611.393884 9139.678495 8083.109273 0.88439755 -0.177233066 0.593974482 1 87.70224951 80.90478231 23326 ubiquitin specific peptidase 22 "GO:0000124,GO:0003713,GO:0004843,GO:0005515,GO:0005654,GO:0006511,GO:0007049,GO:0008234,GO:0008270,GO:0009792,GO:0010485,GO:0016574,GO:0016578,GO:0016579,GO:0018215,GO:0019899,GO:0030374,GO:0043967,GO:0045893,GO:0045931,GO:0070461" "SAGA complex|transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|ubiquitin-dependent protein catabolic process|cell cycle|cysteine-type peptidase activity|zinc ion binding|embryo development ending in birth or egg hatching|H4 histone acetyltransferase activity|histone ubiquitination|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|enzyme binding|nuclear receptor coactivator activity|histone H4 acetylation|positive regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|SAGA-type complex" USP24 3358.135215 3358.489299 3357.781132 0.999789141 -0.000304237 1 1 15.13710376 15.78581952 23358 ubiquitin specific peptidase 24 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0016032,GO:0016579,GO:0018215" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|viral process|protein deubiquitination|protein phosphopantetheinylation USP25 818.7097007 737.872989 899.5464123 1.219107388 0.285825215 0.43502473 1 5.922450687 7.531116159 29761 ubiquitin specific peptidase 25 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005783,GO:0005829,GO:0006464,GO:0006508,GO:0006511,GO:0008233,GO:0016579,GO:0018215,GO:0019783,GO:0031625,GO:0032183,GO:0043130,GO:0051117,GO:0070536,GO:0071108,GO:1904293" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|endoplasmic reticulum|cytosol|cellular protein modification process|proteolysis|ubiquitin-dependent protein catabolic process|peptidase activity|protein deubiquitination|protein phosphopantetheinylation|ubiquitin-like protein-specific protease activity|ubiquitin protein ligase binding|SUMO binding|ubiquitin binding|ATPase binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|negative regulation of ERAD pathway hsa04657 IL-17 signaling pathway USP27X 193.9944074 161.377999 226.6108158 1.404223731 0.489772814 0.369617991 1 2.657959786 3.893145578 389856 ubiquitin specific peptidase 27 X-linked "GO:0004843,GO:0005634,GO:0005829,GO:0006511,GO:0008234,GO:0016579,GO:0018215,GO:0043065,GO:0050821,GO:0061578,GO:0070536,GO:0071108,GO:1990380" thiol-dependent ubiquitin-specific protease activity|nucleus|cytosol|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|positive regulation of apoptotic process|protein stabilization|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|Lys48-specific deubiquitinase activity USP28 1039.057828 1016.98588 1061.129777 1.043406597 0.06130146 0.863450549 1 9.492581483 10.33127309 57646 ubiquitin specific peptidase 28 "GO:0000077,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006511,GO:0006974,GO:0007265,GO:0008283,GO:0010212,GO:0016579,GO:0016604,GO:0018215,GO:0031647,GO:0032991,GO:0034644,GO:0042771" DNA damage checkpoint|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|Ras protein signal transduction|cell population proliferation|response to ionizing radiation|protein deubiquitination|nuclear body|protein phosphopantetheinylation|regulation of protein stability|protein-containing complex|cellular response to UV|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator USP3 557.9427212 558.2257826 557.6596598 0.998985853 -0.001463847 1 1 3.821595916 3.982172163 9960 ubiquitin specific peptidase 3 "GO:0000122,GO:0000278,GO:0000785,GO:0000978,GO:0004843,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006511,GO:0008234,GO:0008270,GO:0016578,GO:0016579,GO:0018215,GO:0031647,GO:0036464,GO:0042393,GO:0090543,GO:1990841" negative regulation of transcription by RNA polymerase II|mitotic cell cycle|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytoplasm|DNA repair|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|zinc ion binding|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|regulation of protein stability|cytoplasmic ribonucleoprotein granule|histone binding|Flemming body|promoter-specific chromatin binding USP30 270.5520757 276.0680234 265.0361281 0.960039213 -0.05883476 0.911713663 1 2.989495719 2.993662505 84749 ubiquitin specific peptidase 30 "GO:0000422,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006511,GO:0008053,GO:0016021,GO:0016579,GO:0018215,GO:0035871,GO:0044313,GO:1901525" autophagy of mitochondrion|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|ubiquitin-dependent protein catabolic process|mitochondrial fusion|integral component of membrane|protein deubiquitination|protein phosphopantetheinylation|protein K11-linked deubiquitination|protein K6-linked deubiquitination|negative regulation of mitophagy hsa04137 Mitophagy - animal USP31 616.5159734 622.1680086 610.8639383 0.981831161 -0.02645314 0.950154006 1 2.405023261 2.463043161 57478 ubiquitin specific peptidase 31 "GO:0004843,GO:0005634,GO:0006511,GO:0008234,GO:0016579,GO:0018215" thiol-dependent ubiquitin-specific protease activity|nucleus|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation USP32 1911.483245 1890.862969 1932.103521 1.021810439 0.03112758 0.924926156 1 12.74664433 13.58570352 84669 ubiquitin specific peptidase 32 "GO:0004843,GO:0005509,GO:0005515,GO:0005794,GO:0005829,GO:0006511,GO:0008234,GO:0016020,GO:0016579,GO:0018215" thiol-dependent ubiquitin-specific protease activity|calcium ion binding|protein binding|Golgi apparatus|cytosol|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|membrane|protein deubiquitination|protein phosphopantetheinylation USP33 1553.222593 1310.308155 1796.137031 1.370774519 0.454991279 0.168386873 1 13.37144581 19.11878641 23032 ubiquitin specific peptidase 33 "GO:0001664,GO:0004197,GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005925,GO:0006511,GO:0006897,GO:0007411,GO:0008270,GO:0008277,GO:0009267,GO:0010506,GO:0016477,GO:0016579,GO:0018215,GO:0030891,GO:0031267,GO:0032091,GO:0032092,GO:0043130,GO:0044297,GO:0048471,GO:0050821,GO:0051298,GO:0070536,GO:0071108" G protein-coupled receptor binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cytosol|focal adhesion|ubiquitin-dependent protein catabolic process|endocytosis|axon guidance|zinc ion binding|regulation of G protein-coupled receptor signaling pathway|cellular response to starvation|regulation of autophagy|cell migration|protein deubiquitination|protein phosphopantetheinylation|VCB complex|small GTPase binding|negative regulation of protein binding|positive regulation of protein binding|ubiquitin binding|cell body|perinuclear region of cytoplasm|protein stabilization|centrosome duplication|protein K63-linked deubiquitination|protein K48-linked deubiquitination USP34 3618.714397 3828.413913 3409.014881 0.89045097 -0.167391919 0.599124771 1 16.60776521 15.42542496 9736 ubiquitin specific peptidase 34 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0016055,GO:0016579,GO:0018215,GO:0071108,GO:0090263" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|Wnt signaling pathway|protein deubiquitination|protein phosphopantetheinylation|protein K48-linked deubiquitination|positive regulation of canonical Wnt signaling pathway USP35 465.875922 427.2964627 504.4553813 1.180574672 0.239489296 0.566836647 1 4.98871794 6.143252148 57558 ubiquitin specific peptidase 35 "GO:0004197,GO:0004843,GO:0005634,GO:0005829,GO:0006511,GO:0016579,GO:0018215" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation USP36 892.9917598 932.7445349 853.2389847 0.914761709 -0.128532118 0.722735506 1 6.587675383 6.28573543 57602 ubiquitin specific peptidase 36 "GO:0003723,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006511,GO:0007000,GO:0016242,GO:0016578,GO:0016579,GO:0016607,GO:0018215,GO:0031647,GO:0042981,GO:0050821,GO:1903146,GO:1903955,GO:2000232" RNA binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|nucleolus organization|negative regulation of macroautophagy|histone deubiquitination|protein deubiquitination|nuclear speck|protein phosphopantetheinylation|regulation of protein stability|regulation of apoptotic process|protein stabilization|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|regulation of rRNA processing USP37 515.2227743 500.3732924 530.0722561 1.059353615 0.083184245 0.841634973 1 3.111756146 3.438447823 57695 ubiquitin specific peptidase 37 "GO:0000082,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006275,GO:0006511,GO:0016579,GO:0018215,GO:0019901,GO:0035871,GO:0051301,GO:0071108" G1/S transition of mitotic cell cycle|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of DNA replication|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|protein kinase binding|protein K11-linked deubiquitination|cell division|protein K48-linked deubiquitination USP38 393.3523453 453.6853179 333.0193728 0.734031629 -0.446085866 0.306345114 1 2.938682804 2.250004647 84640 ubiquitin specific peptidase 38 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0016579,GO:0018215" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation USP39 1178.182509 1098.182358 1258.18266 1.145695568 0.196223745 0.568128774 1 20.26195347 24.21399656 10713 ubiquitin specific peptidase 39 "GO:0000245,GO:0000398,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006397,GO:0007049,GO:0008270,GO:0008380,GO:0016579,GO:0018215,GO:0046540,GO:0051301" "spliceosomal complex assembly|mRNA splicing, via spliceosome|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|spliceosomal complex|mRNA processing|cell cycle|zinc ion binding|RNA splicing|protein deubiquitination|protein phosphopantetheinylation|U4/U6 x U5 tri-snRNP complex|cell division" hsa03040 Spliceosome USP4 913.6783532 797.7553911 1029.601315 1.290622823 0.368067443 0.304246785 1 8.247294601 11.10265331 7375 ubiquitin specific peptidase 4 "GO:0000244,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005829,GO:0005886,GO:0006511,GO:0008234,GO:0016579,GO:0018215,GO:0031397,GO:0031647,GO:0031685,GO:0034394,GO:0042802,GO:0046872" spliceosomal tri-snRNP complex assembly|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|lysosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|negative regulation of protein ubiquitination|regulation of protein stability|adenosine receptor binding|protein localization to cell surface|identical protein binding|metal ion binding USP40 1047.867063 1181.408747 914.3253786 0.773928059 -0.369728629 0.290361777 1 6.573740418 5.30675543 55230 ubiquitin specific peptidase 40 "GO:0004197,GO:0004843,GO:0005634,GO:0005829,GO:0006511,GO:0016579,GO:0018215,GO:0031647" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|regulation of protein stability USP42 498.2181794 516.6125879 479.8237709 0.928788384 -0.106578165 0.798252749 1 4.01482355 3.889548293 84132 ubiquitin specific peptidase 42 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0007283,GO:0016579,GO:0018215,GO:0030154,GO:0042981" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|spermatogenesis|protein deubiquitination|protein phosphopantetheinylation|cell differentiation|regulation of apoptotic process USP43 175.4349654 206.0360616 144.8338692 0.702953979 -0.508497854 0.367352837 1 1.608353833 1.179300334 124739 ubiquitin specific peptidase 43 "GO:0004843,GO:0005654,GO:0006511,GO:0016579,GO:0018215,GO:0019785,GO:0019985" thiol-dependent ubiquitin-specific protease activity|nucleoplasm|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|ISG15-specific protease activity|translesion synthesis USP45 233.3550035 225.320225 241.3897821 1.071318751 0.099387791 0.853753224 1 0.929743728 1.038957765 85015 ubiquitin specific peptidase 45 "GO:0001917,GO:0003407,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006511,GO:0008234,GO:0008270,GO:0016477,GO:0016579,GO:0018215,GO:0045494,GO:0070911" photoreceptor inner segment|neural retina development|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|zinc ion binding|cell migration|protein deubiquitination|protein phosphopantetheinylation|photoreceptor cell maintenance|global genome nucleotide-excision repair USP46 408.9653966 477.0293051 340.9014881 0.714634268 -0.484723 0.260945574 1 2.897212069 2.159633486 64854 ubiquitin specific peptidase 46 "GO:0001662,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0008343,GO:0016579,GO:0018215,GO:0032228,GO:0046872,GO:0048149,GO:0060013,GO:0098978,GO:0099149" "behavioral fear response|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|adult feeding behavior|protein deubiquitination|protein phosphopantetheinylation|regulation of synaptic transmission, GABAergic|metal ion binding|behavioral response to ethanol|righting reflex|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization" USP47 1471.508989 1449.357123 1493.660855 1.030567851 0.043439493 0.897948203 1 8.684905969 9.335931162 55031 ubiquitin specific peptidase 47 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006284,GO:0006511,GO:0006974,GO:0010972,GO:0016579,GO:0018215,GO:0019005,GO:0030307,GO:0031647,GO:0034644,GO:0035520,GO:0042493,GO:0043066,GO:0043154,GO:0045892,GO:0071987,GO:0090263,GO:0101005,GO:1902230" "cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|base-excision repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|protein phosphopantetheinylation|SCF ubiquitin ligase complex|positive regulation of cell growth|regulation of protein stability|cellular response to UV|monoubiquitinated protein deubiquitination|response to drug|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|WD40-repeat domain binding|positive regulation of canonical Wnt signaling pathway|ubiquitinyl hydrolase activity|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage" USP48 1297.477692 1238.246281 1356.709102 1.095669837 0.13181313 0.697893684 1 11.65448911 13.31952926 84196 ubiquitin specific peptidase 48 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006511,GO:0016579,GO:0018215" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation USP49 259.1972866 207.0510175 311.3435556 1.503704543 0.588521125 0.235387324 1 1.045712366 1.640176878 25862 ubiquitin specific peptidase 49 "GO:0000398,GO:0004197,GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0006511,GO:0008270,GO:0016579,GO:0018215,GO:0035616,GO:0042393" "mRNA splicing, via spliceosome|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|ubiquitin-dependent protein catabolic process|zinc ion binding|protein deubiquitination|protein phosphopantetheinylation|histone H2B conserved C-terminal lysine deubiquitination|histone binding" USP5 2948.257299 3088.511012 2808.003587 0.909177133 -0.137366696 0.666409015 1 49.83185318 47.25757935 8078 ubiquitin specific peptidase 5 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005764,GO:0005829,GO:0006511,GO:0008270,GO:0016567,GO:0016579,GO:0018215,GO:0032436,GO:0043130,GO:0071108" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|lysosome|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|protein ubiquitination|protein deubiquitination|protein phosphopantetheinylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin binding|protein K48-linked deubiquitination USP51 51.48340625 50.74779842 52.21901408 1.028990729 0.041229984 0.986980443 1 0.542808229 0.582604472 158880 ubiquitin specific peptidase 51 "GO:0003682,GO:0004843,GO:0005694,GO:0006281,GO:0006511,GO:0008234,GO:0008270,GO:0010564,GO:0010569,GO:0016578,GO:0016579,GO:0018215,GO:0042393,GO:2001020,GO:2001032" chromatin binding|thiol-dependent ubiquitin-specific protease activity|chromosome|DNA repair|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|zinc ion binding|regulation of cell cycle process|regulation of double-strand break repair via homologous recombination|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|histone binding|regulation of response to DNA damage stimulus|regulation of double-strand break repair via nonhomologous end joining USP53 956.2228724 809.9348628 1102.510882 1.361234011 0.444915104 0.210493382 1 5.607702463 7.962211031 54532 ubiquitin specific peptidase 53 "GO:0001508,GO:0004843,GO:0005515,GO:0005575,GO:0005911,GO:0005923,GO:0007605,GO:0008150,GO:0010996,GO:0016579,GO:0018215,GO:0051402" action potential|thiol-dependent ubiquitin-specific protease activity|protein binding|cellular_component|cell-cell junction|bicellular tight junction|sensory perception of sound|biological_process|response to auditory stimulus|protein deubiquitination|protein phosphopantetheinylation|neuron apoptotic process USP54 1263.859935 1230.126634 1297.593237 1.05484525 0.077031366 0.822317199 1 6.430134624 7.07497235 159195 ubiquitin specific peptidase 54 "GO:0004843,GO:0005515,GO:0016579,GO:0018215" thiol-dependent ubiquitin-specific protease activity|protein binding|protein deubiquitination|protein phosphopantetheinylation USP6 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.012508056 0 9098 ubiquitin specific peptidase 6 "GO:0003676,GO:0004197,GO:0004843,GO:0005096,GO:0005515,GO:0005516,GO:0005737,GO:0005764,GO:0005886,GO:0006464,GO:0006511,GO:0006886,GO:0016579,GO:0018215,GO:0055037,GO:0060627,GO:0090630" nucleic acid binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|GTPase activator activity|protein binding|calmodulin binding|cytoplasm|lysosome|plasma membrane|cellular protein modification process|ubiquitin-dependent protein catabolic process|intracellular protein transport|protein deubiquitination|protein phosphopantetheinylation|recycling endosome|regulation of vesicle-mediated transport|activation of GTPase activity USP6NL 953.488282 1027.13544 879.841124 0.856596988 -0.223311491 0.53056401 1 5.92289497 5.292081258 9712 USP6 N-terminal like "GO:0005096,GO:0005829,GO:0005886,GO:0006886,GO:0007030,GO:0019068,GO:0031267,GO:0031410,GO:0032588,GO:0035526,GO:0043547,GO:0048227,GO:0090630,GO:1902017,GO:1903358" "GTPase activator activity|cytosol|plasma membrane|intracellular protein transport|Golgi organization|virion assembly|small GTPase binding|cytoplasmic vesicle|trans-Golgi network membrane|retrograde transport, plasma membrane to Golgi|positive regulation of GTPase activity|plasma membrane to endosome transport|activation of GTPase activity|regulation of cilium assembly|regulation of Golgi organization" USP7 2015.398703 2259.291986 1771.505421 0.784097599 -0.350894853 0.276076275 1 17.42957635 14.25518589 7874 ubiquitin specific peptidase 7 "GO:0002039,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006111,GO:0006283,GO:0006511,GO:0007275,GO:0008022,GO:0008134,GO:0010216,GO:0016032,GO:0016567,GO:0016579,GO:0016604,GO:0016605,GO:0018215,GO:0031625,GO:0031647,GO:0032088,GO:0032435,GO:0032991,GO:0035520,GO:0035616,GO:0042752,GO:0048511,GO:0050821,GO:0051090,GO:0070536,GO:0071108,GO:0101005,GO:1901537,GO:1904353,GO:1905279,GO:1990380" "p53 binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|chromosome|cytosol|regulation of gluconeogenesis|transcription-coupled nucleotide-excision repair|ubiquitin-dependent protein catabolic process|multicellular organism development|protein C-terminus binding|transcription factor binding|maintenance of DNA methylation|viral process|protein ubiquitination|protein deubiquitination|nuclear body|PML body|protein phosphopantetheinylation|ubiquitin protein ligase binding|regulation of protein stability|negative regulation of NF-kappaB transcription factor activity|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|monoubiquitinated protein deubiquitination|histone H2B conserved C-terminal lysine deubiquitination|regulation of circadian rhythm|rhythmic process|protein stabilization|regulation of DNA-binding transcription factor activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|ubiquitinyl hydrolase activity|positive regulation of DNA demethylation|regulation of telomere capping|regulation of retrograde transport, endosome to Golgi|Lys48-specific deubiquitinase activity" "hsa04068,hsa05169,hsa05203" FoxO signaling pathway|Epstein-Barr virus infection|Viral carcinogenesis USP8 1033.119272 981.4624214 1084.776123 1.105265061 0.144392393 0.681800133 1 10.5558737 12.16960708 9101 ubiquitin specific peptidase 8 "GO:0000281,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0006511,GO:0007032,GO:0007265,GO:0014069,GO:0016579,GO:0017124,GO:0018215,GO:0019897,GO:0030496,GO:0031313,GO:0031647,GO:0032880,GO:0043197,GO:0045296,GO:0070536,GO:0071108,GO:0071549,GO:0090263,GO:0098978,GO:0099576,GO:1990090" "mitotic cytokinesis|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|early endosome|cytosol|ubiquitin-dependent protein catabolic process|endosome organization|Ras protein signal transduction|postsynaptic density|protein deubiquitination|SH3 domain binding|protein phosphopantetheinylation|extrinsic component of plasma membrane|midbody|extrinsic component of endosome membrane|regulation of protein stability|regulation of protein localization|dendritic spine|cadherin binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|cellular response to dexamethasone stimulus|positive regulation of canonical Wnt signaling pathway|glutamatergic synapse|regulation of protein catabolic process at postsynapse, modulating synaptic transmission|cellular response to nerve growth factor stimulus" "hsa04137,hsa04144,hsa04934" Mitophagy - animal|Endocytosis|Cushing syndrome USP9X 6849.862588 7093.527263 6606.197913 0.931299432 -0.102682996 0.753768163 1 35.94058938 34.91326482 8239 ubiquitin specific peptidase 9 X-linked "GO:0000122,GO:0001764,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006625,GO:0007049,GO:0007059,GO:0007179,GO:0007292,GO:0008234,GO:0016020,GO:0016477,GO:0016567,GO:0016579,GO:0018215,GO:0030426,GO:0030509,GO:0042752,GO:0044267,GO:0048511,GO:0048675,GO:0050821,GO:0051301,GO:0070410,GO:0071108,GO:0071947,GO:0101005,GO:1901537,GO:1990380" negative regulation of transcription by RNA polymerase II|neuron migration|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|cytosol|protein targeting to peroxisome|cell cycle|chromosome segregation|transforming growth factor beta receptor signaling pathway|female gamete generation|cysteine-type peptidase activity|membrane|cell migration|protein ubiquitination|protein deubiquitination|protein phosphopantetheinylation|growth cone|BMP signaling pathway|regulation of circadian rhythm|cellular protein metabolic process|rhythmic process|axon extension|protein stabilization|cell division|co-SMAD binding|protein K48-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitinyl hydrolase activity|positive regulation of DNA demethylation|Lys48-specific deubiquitinase activity USPL1 456.3620091 484.1339969 428.5900212 0.885271483 -0.175808147 0.677221366 1 4.773151454 4.407553769 10208 ubiquitin specific peptidase like 1 "GO:0005515,GO:0005615,GO:0008283,GO:0009301,GO:0015030,GO:0016926,GO:0030576,GO:0032183,GO:0043130,GO:0070140" protein binding|extracellular space|cell population proliferation|snRNA transcription|Cajal body|protein desumoylation|Cajal body organization|SUMO binding|ubiquitin binding|SUMO-specific isopeptidase activity UST 202.56215 174.5724266 230.5518735 1.32066603 0.401265684 0.456901157 1 1.269962303 1.749442877 10090 uronyl 2-sulfotransferase "GO:0000139,GO:0006477,GO:0008146,GO:0016021,GO:0030010,GO:0030208,GO:0050770" Golgi membrane|protein sulfation|sulfotransferase activity|integral component of membrane|establishment of cell polarity|dermatan sulfate biosynthetic process|regulation of axonogenesis hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate UTP11 493.8856883 557.2108266 430.56055 0.77270672 -0.372007151 0.364622234 1 13.82692927 11.14439149 51118 UTP11 small subunit processome component "GO:0003723,GO:0005515,GO:0005615,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0007399,GO:0032040,GO:0043065" RNA binding|protein binding|extracellular space|nucleoplasm|nucleolus|cytoplasm|rRNA processing|nervous system development|small-subunit processome|positive regulation of apoptotic process UTP14A 745.7474317 835.308762 656.1861014 0.785561138 -0.348204535 0.35042753 1 15.33917404 12.56891807 10813 UTP14A small subunit processome component "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0032040" RNA binding|protein binding|nucleoplasm|nucleolus|cytosol|rRNA processing|small-subunit processome hsa03008 Ribosome biogenesis in eukaryotes UTP15 444.5806518 520.6724118 368.4888918 0.707717335 -0.498754837 0.236574696 1 4.91981732 3.63182355 84135 UTP15 small subunit processome component "GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0006364,GO:0045943,GO:2000234" fibrillar center|RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|rRNA processing|positive regulation of transcription by RNA polymerase I|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes UTP18 748.8395585 810.9498187 686.7292983 0.846820953 -0.239871128 0.52045127 1 14.45170565 12.76517087 51096 UTP18 small subunit processome component "GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0031965,GO:0032040,GO:0034388" RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|nuclear membrane|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome hsa03008 Ribosome biogenesis in eukaryotes UTP20 1778.908519 1853.309598 1704.507441 0.919710038 -0.120749009 0.711532693 1 10.39348833 9.970758301 27340 UTP20 small subunit processome component "GO:0000447,GO:0000472,GO:0000480,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005886,GO:0006364,GO:0008285,GO:0030686,GO:0030688,GO:0032040" "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|plasma membrane|rRNA processing|negative regulation of cell population proliferation|90S preribosome|preribosome, small subunit precursor|small-subunit processome" UTP23 529.2958242 553.1510028 505.4406457 0.913748042 -0.130131685 0.749928684 1 7.629397301 7.271644194 84294 UTP23 small subunit processome component "GO:0000480,GO:0003723,GO:0003730,GO:0005515,GO:0005730,GO:0032040,GO:0048027,GO:0070181" "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|mRNA 3'-UTR binding|protein binding|nucleolus|small-subunit processome|mRNA 5'-UTR binding|small ribosomal subunit rRNA binding" UTP25 1090.765159 1251.440709 930.0896092 0.743215082 -0.428148316 0.217750219 1 7.44258538 5.769713779 27042 UTP25 small subunit processor component "GO:0000462,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0007275,GO:0019843,GO:0030163,GO:0031648,GO:0032040,GO:0034511,GO:0040019" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|multicellular organism development|rRNA binding|protein catabolic process|protein destabilization|small-subunit processome|U3 snoRNA binding|positive regulation of embryonic development" UTP3 745.8689195 809.9348628 681.8029763 0.841799764 -0.24845099 0.505901986 1 20.30710075 17.83087489 57050 UTP3 small subunit processome component "GO:0000462,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006325,GO:0006364,GO:0007420,GO:0032040" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|chromatin organization|rRNA processing|brain development|small-subunit processome" UTP4 1025.713459 1182.423703 869.0032154 0.734933859 -0.444313675 0.205509663 1 25.54845957 19.58524035 84916 UTP4 small subunit processome component "GO:0000462,GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0006355,GO:0006364,GO:0030490,GO:0030686,GO:0032040,GO:0034455" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|fibrillar center|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|regulation of transcription, DNA-templated|rRNA processing|maturation of SSU-rRNA|90S preribosome|small-subunit processome|t-UTP complex" hsa03008 Ribosome biogenesis in eukaryotes UTP6 1074.848511 1106.302006 1043.395017 0.943137599 -0.084459827 0.810397211 1 12.83920572 12.6307502 55813 UTP6 small subunit processome component "GO:0000462,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0006364,GO:0030515,GO:0032040,GO:0034388" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|protein binding|nucleoplasm|chromosome|nucleolus|rRNA processing|snoRNA binding|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome" hsa03008 Ribosome biogenesis in eukaryotes UTRN 1915.024951 1661.48292 2168.566981 1.305199683 0.384270542 0.234780233 1 5.183776785 7.05730979 7402 utrophin "GO:0001954,GO:0003779,GO:0005178,GO:0005515,GO:0005654,GO:0005737,GO:0005856,GO:0005886,GO:0006936,GO:0007517,GO:0007528,GO:0008270,GO:0014894,GO:0016010,GO:0016020,GO:0017166,GO:0019901,GO:0030175,GO:0030426,GO:0030864,GO:0031527,GO:0031594,GO:0032991,GO:0042383,GO:0045211,GO:0051015,GO:0070062,GO:0070938,GO:2000649" positive regulation of cell-matrix adhesion|actin binding|integrin binding|protein binding|nucleoplasm|cytoplasm|cytoskeleton|plasma membrane|muscle contraction|muscle organ development|neuromuscular junction development|zinc ion binding|response to denervation involved in regulation of muscle adaptation|dystrophin-associated glycoprotein complex|membrane|vinculin binding|protein kinase binding|filopodium|growth cone|cortical actin cytoskeleton|filopodium membrane|neuromuscular junction|protein-containing complex|sarcolemma|postsynaptic membrane|actin filament binding|extracellular exosome|contractile ring|regulation of sodium ion transmembrane transporter activity UVRAG 496.5824224 438.4609783 554.7038665 1.265115698 0.339269329 0.407979539 1 2.619617996 3.456878691 7405 UV radiation resistance associated "GO:0000149,GO:0000323,GO:0000421,GO:0000775,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005783,GO:0005813,GO:0006281,GO:0006890,GO:0006914,GO:0007051,GO:0007059,GO:0007098,GO:0017124,GO:0030496,GO:0032465,GO:0032801,GO:0035493,GO:0045335,GO:0046718,GO:0051684,GO:0070418,GO:0071900,GO:0071985,GO:0097352,GO:0097680,GO:1901098" "SNARE binding|lytic vacuole|autophagosome membrane|chromosome, centromeric region|protein binding|cytoplasm|lysosome|endosome|early endosome|late endosome|endoplasmic reticulum|centrosome|DNA repair|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|autophagy|spindle organization|chromosome segregation|centrosome cycle|SH3 domain binding|midbody|regulation of cytokinesis|receptor catabolic process|SNARE complex assembly|phagocytic vesicle|viral entry into host cell|maintenance of Golgi location|DNA-dependent protein kinase complex|regulation of protein serine/threonine kinase activity|multivesicular body sorting pathway|autophagosome maturation|double-strand break repair via classical nonhomologous end joining|positive regulation of autophagosome maturation" hsa04140 Autophagy - animal UVSSA 335.6752828 383.653356 287.6972096 0.749888422 -0.415252147 0.36394878 1 1.163374987 0.909980949 57654 UV stimulated scaffold protein A "GO:0000993,GO:0005515,GO:0005654,GO:0005694,GO:0006283,GO:0009411,GO:0016567" RNA polymerase II complex binding|protein binding|nucleoplasm|chromosome|transcription-coupled nucleotide-excision repair|response to UV|protein ubiquitination UXS1 1416.764709 1478.790846 1354.738573 0.916112361 -0.12640354 0.706266006 1 19.72492481 18.8486404 80146 UDP-glucuronate decarboxylase 1 "GO:0005737,GO:0016021,GO:0032580,GO:0033320,GO:0042802,GO:0042803,GO:0048040,GO:0070062,GO:0070403,GO:1902494" cytoplasm|integral component of membrane|Golgi cisterna membrane|UDP-D-xylose biosynthetic process|identical protein binding|protein homodimerization activity|UDP-glucuronate decarboxylase activity|extracellular exosome|NAD+ binding|catalytic complex hsa00520 Amino sugar and nucleotide sugar metabolism UXT 1101.423681 1070.778547 1132.068815 1.057238976 0.080301518 0.818952439 1 70.15673468 77.36748202 8409 ubiquitously expressed prefoldin like chaperone "GO:0000122,GO:0000226,GO:0000785,GO:0000922,GO:0000930,GO:0003682,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005856,GO:0006915,GO:0007098,GO:0008017,GO:0016592,GO:0045944,GO:0047497,GO:0048487,GO:0051015,GO:0070317" negative regulation of transcription by RNA polymerase II|microtubule cytoskeleton organization|chromatin|spindle pole|gamma-tubulin complex|chromatin binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytoskeleton|apoptotic process|centrosome cycle|microtubule binding|mediator complex|positive regulation of transcription by RNA polymerase II|mitochondrion transport along microtubule|beta-tubulin binding|actin filament binding|negative regulation of G0 to G1 transition VAC14 1226.583191 1241.291149 1211.875232 0.976302162 -0.03460037 0.921550797 1 3.462221484 3.52577852 55697 VAC14 component of PIKFYVE complex "GO:0000139,GO:0000306,GO:0005515,GO:0005783,GO:0005829,GO:0006661,GO:0007165,GO:0010008,GO:0016032,GO:0031901,GO:0031902,GO:0033674,GO:0038023,GO:0042802,GO:0043231,GO:0070772" Golgi membrane|extrinsic component of vacuolar membrane|protein binding|endoplasmic reticulum|cytosol|phosphatidylinositol biosynthetic process|signal transduction|endosome membrane|viral process|early endosome membrane|late endosome membrane|positive regulation of kinase activity|signaling receptor activity|identical protein binding|intracellular membrane-bounded organelle|PAS complex "hsa05166,hsa05203" Human T-cell leukemia virus 1 infection|Viral carcinogenesis VAMP1 156.8270267 112.6601125 200.993941 1.784073676 0.835175194 0.153401777 1 1.817724516 3.382647785 6843 vesicle associated membrane protein 1 "GO:0005484,GO:0005515,GO:0005741,GO:0005829,GO:0005886,GO:0005887,GO:0006906,GO:0019905,GO:0030285,GO:0030672,GO:0031201,GO:0035493,GO:0035577,GO:0035579,GO:0043005,GO:0070821" SNAP receptor activity|protein binding|mitochondrial outer membrane|cytosol|plasma membrane|integral component of plasma membrane|vesicle fusion|syntaxin binding|integral component of synaptic vesicle membrane|synaptic vesicle membrane|SNARE complex|SNARE complex assembly|azurophil granule membrane|specific granule membrane|neuron projection|tertiary granule membrane hsa04130 SNARE interactions in vesicular transport VAMP2 621.3910772 517.6275439 725.1546106 1.400919675 0.486374238 0.210003608 1 10.23662984 14.95843518 6844 vesicle associated membrane protein 2 "GO:0000149,GO:0005484,GO:0005515,GO:0005516,GO:0005543,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0006887,GO:0006892,GO:0006906,GO:0007269,GO:0008021,GO:0008076,GO:0009749,GO:0014047,GO:0015031,GO:0016020,GO:0016079,GO:0016192,GO:0017075,GO:0017156,GO:0017157,GO:0019905,GO:0030136,GO:0030141,GO:0030665,GO:0030667,GO:0030672,GO:0031201,GO:0031410,GO:0031982,GO:0032869,GO:0035493,GO:0042589,GO:0043001,GO:0043005,GO:0043231,GO:0043308,GO:0043312,GO:0043320,GO:0043621,GO:0044306,GO:0045202,GO:0048306,GO:0048471,GO:0048488,GO:0060203,GO:0060291,GO:0060627,GO:0061024,GO:0061025,GO:0061202,GO:0065003,GO:0070032,GO:0070033,GO:0070044,GO:0070083,GO:0070254,GO:0090316,GO:1902259,GO:1903593" SNARE binding|SNAP receptor activity|protein binding|calmodulin binding|phospholipid binding|trans-Golgi network|cytosol|plasma membrane|integral component of plasma membrane|exocytosis|post-Golgi vesicle-mediated transport|vesicle fusion|neurotransmitter secretion|synaptic vesicle|voltage-gated potassium channel complex|response to glucose|glutamate secretion|protein transport|membrane|synaptic vesicle exocytosis|vesicle-mediated transport|syntaxin-1 binding|calcium-ion regulated exocytosis|regulation of exocytosis|syntaxin binding|clathrin-coated vesicle|secretory granule|clathrin-coated vesicle membrane|secretory granule membrane|synaptic vesicle membrane|SNARE complex|cytoplasmic vesicle|vesicle|cellular response to insulin stimulus|SNARE complex assembly|zymogen granule membrane|Golgi to plasma membrane protein transport|neuron projection|intracellular membrane-bounded organelle|eosinophil degranulation|neutrophil degranulation|natural killer cell degranulation|protein self-association|neuron projection terminus|synapse|calcium-dependent protein binding|perinuclear region of cytoplasm|synaptic vesicle endocytosis|clathrin-sculpted glutamate transport vesicle membrane|long-term synaptic potentiation|regulation of vesicle-mediated transport|membrane organization|membrane fusion|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|protein-containing complex assembly|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex|synaptobrevin 2-SNAP-25-syntaxin-1a complex|clathrin-sculpted monoamine transport vesicle membrane|mucus secretion|positive regulation of intracellular protein transport|regulation of delayed rectifier potassium channel activity|regulation of histamine secretion by mast cell "hsa04130,hsa04721,hsa04911,hsa04962,hsa04970" SNARE interactions in vesicular transport|Synaptic vesicle cycle|Insulin secretion|Vasopressin-regulated water reabsorption|Salivary secretion VAMP3 3602.016612 3192.036521 4011.996704 1.256876818 0.329843263 0.300116504 1 73.51768483 96.38300619 9341 vesicle associated membrane protein 3 "GO:0001921,GO:0002479,GO:0002639,GO:0005484,GO:0005515,GO:0005769,GO:0005829,GO:0005886,GO:0006887,GO:0006904,GO:0006906,GO:0009986,GO:0016021,GO:0016192,GO:0016324,GO:0017075,GO:0017156,GO:0019905,GO:0030133,GO:0030136,GO:0030141,GO:0030285,GO:0030665,GO:0030670,GO:0031201,GO:0032588,GO:0034446,GO:0035493,GO:0042147,GO:0043001,GO:0043005,GO:0043231,GO:0048471,GO:0055037,GO:0055038,GO:0061024,GO:0061025,GO:0065003,GO:0070254,GO:0071346,GO:1903531,GO:1903593" "positive regulation of receptor recycling|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|positive regulation of immunoglobulin production|SNAP receptor activity|protein binding|early endosome|cytosol|plasma membrane|exocytosis|vesicle docking involved in exocytosis|vesicle fusion|cell surface|integral component of membrane|vesicle-mediated transport|apical plasma membrane|syntaxin-1 binding|calcium-ion regulated exocytosis|syntaxin binding|transport vesicle|clathrin-coated vesicle|secretory granule|integral component of synaptic vesicle membrane|clathrin-coated vesicle membrane|phagocytic vesicle membrane|SNARE complex|trans-Golgi network membrane|substrate adhesion-dependent cell spreading|SNARE complex assembly|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport|neuron projection|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|membrane organization|membrane fusion|protein-containing complex assembly|mucus secretion|cellular response to interferon-gamma|negative regulation of secretion by cell|regulation of histamine secretion by mast cell" "hsa04130,hsa04145" SNARE interactions in vesicular transport|Phagosome VAMP4 359.4188683 289.262451 429.5752856 1.485071029 0.570531934 0.202528918 1 2.545191572 3.9426083 8674 vesicle associated membrane protein 4 "GO:0000139,GO:0000226,GO:0005515,GO:0005764,GO:0005768,GO:0005794,GO:0005802,GO:0005886,GO:0006888,GO:0008021,GO:0009986,GO:0016189,GO:0030133,GO:0030285,GO:0030665,GO:0031201,GO:0032588,GO:0035493,GO:0043001,GO:0061024,GO:0090161,GO:1900242" Golgi membrane|microtubule cytoskeleton organization|protein binding|lysosome|endosome|Golgi apparatus|trans-Golgi network|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|synaptic vesicle|cell surface|synaptic vesicle to endosome fusion|transport vesicle|integral component of synaptic vesicle membrane|clathrin-coated vesicle membrane|SNARE complex|trans-Golgi network membrane|SNARE complex assembly|Golgi to plasma membrane protein transport|membrane organization|Golgi ribbon formation|regulation of synaptic vesicle endocytosis hsa04130 SNARE interactions in vesicular transport VAMP5 169.9445038 167.4677348 172.4212729 1.02957906 0.042054616 0.952106334 1 12.85098481 13.8010472 10791 vesicle associated membrane protein 5 "GO:0005515,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0007517,GO:0007519,GO:0009986,GO:0014704,GO:0030154,GO:0030659,GO:0031301,GO:0043001,GO:0048471,GO:0070062" protein binding|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|muscle organ development|skeletal muscle tissue development|cell surface|intercalated disc|cell differentiation|cytoplasmic vesicle membrane|integral component of organelle membrane|Golgi to plasma membrane protein transport|perinuclear region of cytoplasm|extracellular exosome hsa04130 SNARE interactions in vesicular transport VAMP7 31.9144515 26.38885518 37.44004783 1.418782572 0.504653514 0.618219955 1 0.522888271 0.773821291 6845 vesicle associated membrane protein 7 "GO:0000149,GO:0005484,GO:0005515,GO:0005737,GO:0005765,GO:0005789,GO:0005802,GO:0005886,GO:0006887,GO:0006888,GO:0006892,GO:0006906,GO:0006911,GO:0008333,GO:0015031,GO:0016020,GO:0016192,GO:0017156,GO:0019905,GO:0030027,GO:0030141,GO:0030175,GO:0030285,GO:0030665,GO:0030667,GO:0030670,GO:0031091,GO:0031143,GO:0031201,GO:0031902,GO:0034197,GO:0035577,GO:0043005,GO:0043231,GO:0043308,GO:0043312,GO:0043320,GO:0045335,GO:0047496,GO:0048280,GO:0048471,GO:0061024,GO:0070062,GO:0097352,GO:0098686,GO:1903595" "SNARE binding|SNAP receptor activity|protein binding|cytoplasm|lysosomal membrane|endoplasmic reticulum membrane|trans-Golgi network|plasma membrane|exocytosis|endoplasmic reticulum to Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport|vesicle fusion|phagocytosis, engulfment|endosome to lysosome transport|protein transport|membrane|vesicle-mediated transport|calcium-ion regulated exocytosis|syntaxin binding|lamellipodium|secretory granule|filopodium|integral component of synaptic vesicle membrane|clathrin-coated vesicle membrane|secretory granule membrane|phagocytic vesicle membrane|platelet alpha granule|pseudopodium|SNARE complex|late endosome membrane|triglyceride transport|azurophil granule membrane|neuron projection|intracellular membrane-bounded organelle|eosinophil degranulation|neutrophil degranulation|natural killer cell degranulation|phagocytic vesicle|vesicle transport along microtubule|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|membrane organization|extracellular exosome|autophagosome maturation|hippocampal mossy fiber to CA3 synapse|positive regulation of histamine secretion by mast cell" hsa04130 SNARE interactions in vesicular transport VAMP8 1128.060955 1005.821365 1250.300545 1.243064215 0.313900825 0.363687579 1 59.02816199 76.53652751 8673 vesicle associated membrane protein 8 "GO:0002479,GO:0005484,GO:0005515,GO:0005737,GO:0005765,GO:0005769,GO:0005829,GO:0005886,GO:0006892,GO:0006906,GO:0015031,GO:0016020,GO:0016021,GO:0016240,GO:0019869,GO:0019905,GO:0030665,GO:0030667,GO:0030670,GO:0031201,GO:0031901,GO:0031902,GO:0031982,GO:0035493,GO:0035577,GO:0035579,GO:0043308,GO:0043312,GO:0046718,GO:0048471,GO:0051607,GO:0055037,GO:0055038,GO:0061024,GO:0070062,GO:0070254,GO:0070821,GO:0097352,GO:0098594,GO:1903076,GO:1903531,GO:1903595" "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|SNAP receptor activity|protein binding|cytoplasm|lysosomal membrane|early endosome|cytosol|plasma membrane|post-Golgi vesicle-mediated transport|vesicle fusion|protein transport|membrane|integral component of membrane|autophagosome membrane docking|chloride channel inhibitor activity|syntaxin binding|clathrin-coated vesicle membrane|secretory granule membrane|phagocytic vesicle membrane|SNARE complex|early endosome membrane|late endosome membrane|vesicle|SNARE complex assembly|azurophil granule membrane|specific granule membrane|eosinophil degranulation|neutrophil degranulation|viral entry into host cell|perinuclear region of cytoplasm|defense response to virus|recycling endosome|recycling endosome membrane|membrane organization|extracellular exosome|mucus secretion|tertiary granule membrane|autophagosome maturation|mucin granule|regulation of protein localization to plasma membrane|negative regulation of secretion by cell|positive regulation of histamine secretion by mast cell" "hsa04130,hsa04140,hsa04611" SNARE interactions in vesicular transport|Autophagy - animal|Platelet activation VANGL1 2229.737013 2093.854163 2365.619864 1.129792087 0.176057301 0.582908561 1 12.12096544 14.28406019 81839 VANGL planar cell polarity protein 1 "GO:0005515,GO:0005886,GO:0007275,GO:0016021,GO:0016328,GO:0043473,GO:0060071" "protein binding|plasma membrane|multicellular organism development|integral component of membrane|lateral plasma membrane|pigmentation|Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway VAPA 2761.201559 2963.671428 2558.73169 0.863365509 -0.211956636 0.505883826 1 34.36343924 30.94619429 9218 VAMP associated protein A "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005923,GO:0006888,GO:0007029,GO:0008017,GO:0008219,GO:0016021,GO:0016032,GO:0019904,GO:0030148,GO:0031175,GO:0031965,GO:0031982,GO:0033149,GO:0034975,GO:0035577,GO:0043123,GO:0043312,GO:0044791,GO:0044828,GO:0044829,GO:0045296,GO:0046982,GO:0048471,GO:0061025,GO:0070971,GO:0070972,GO:0090114" Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|bicellular tight junction|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|microtubule binding|cell death|integral component of membrane|viral process|protein domain specific binding|sphingolipid biosynthetic process|neuron projection development|nuclear membrane|vesicle|FFAT motif binding|protein folding in endoplasmic reticulum|azurophil granule membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|positive regulation by host of viral release from host cell|negative regulation by host of viral genome replication|positive regulation by host of viral genome replication|cadherin binding|protein heterodimerization activity|perinuclear region of cytoplasm|membrane fusion|endoplasmic reticulum exit site|protein localization to endoplasmic reticulum|COPII-coated vesicle budding hsa04979 Cholesterol metabolism VAPB 3246.732788 3454.910116 3038.555461 0.879489005 -0.185262553 0.560468476 1 22.35010975 20.50340565 9217 VAMP associated protein B and C "GO:0000139,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006874,GO:0006888,GO:0007029,GO:0008017,GO:0016021,GO:0019048,GO:0019899,GO:0030148,GO:0030968,GO:0033149,GO:0036498,GO:0042803,GO:0045070,GO:0045296,GO:0046982,GO:0048487,GO:0061817,GO:0070971,GO:0090114,GO:0090158" Golgi membrane|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|cellular calcium ion homeostasis|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|microtubule binding|integral component of membrane|modulation by virus of host process|enzyme binding|sphingolipid biosynthetic process|endoplasmic reticulum unfolded protein response|FFAT motif binding|IRE1-mediated unfolded protein response|protein homodimerization activity|positive regulation of viral genome replication|cadherin binding|protein heterodimerization activity|beta-tubulin binding|endoplasmic reticulum-plasma membrane tethering|endoplasmic reticulum exit site|COPII-coated vesicle budding|endoplasmic reticulum membrane organization "hsa04979,hsa05014,hsa05022" Cholesterol metabolism|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases VARS1 1982.469296 2230.873218 1734.065373 0.777303416 -0.363450239 0.259819044 1 28.77887378 23.33352219 7407 valyl-tRNA synthetase 1 "GO:0002161,GO:0004832,GO:0005515,GO:0005524,GO:0005829,GO:0006418,GO:0006438,GO:0106074" aminoacyl-tRNA editing activity|valine-tRNA ligase activity|protein binding|ATP binding|cytosol|tRNA aminoacylation for protein translation|valyl-tRNA aminoacylation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis VARS2 861.413318 996.6867609 726.139875 0.728553748 -0.456892686 0.207151601 1 14.10018669 10.715252 57176 "valyl-tRNA synthetase 2, mitochondrial" "GO:0002161,GO:0004832,GO:0005515,GO:0005524,GO:0005739,GO:0005829,GO:0006438,GO:0106074" aminoacyl-tRNA editing activity|valine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|cytosol|valyl-tRNA aminoacylation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis VASH1 1213.253914 1037.285 1389.222827 1.339287494 0.421465685 0.217273707 1 7.843360094 10.95700595 22846 vasohibin 1 "GO:0001525,GO:0001937,GO:0003779,GO:0004181,GO:0005515,GO:0005615,GO:0005737,GO:0005783,GO:0006508,GO:0007050,GO:0009611,GO:0010596,GO:0016525,GO:0043537,GO:0045177,GO:0045765,GO:0060716,GO:1901491,GO:2000772" angiogenesis|negative regulation of endothelial cell proliferation|actin binding|metallocarboxypeptidase activity|protein binding|extracellular space|cytoplasm|endoplasmic reticulum|proteolysis|cell cycle arrest|response to wounding|negative regulation of endothelial cell migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|apical part of cell|regulation of angiogenesis|labyrinthine layer blood vessel development|negative regulation of lymphangiogenesis|regulation of cellular senescence VASH2 45.33428733 34.50850292 56.16007174 1.627427068 0.702592892 0.426853167 1 0.408635477 0.693670992 79805 vasohibin 2 "GO:0000768,GO:0001938,GO:0003779,GO:0004181,GO:0005515,GO:0005576,GO:0005737,GO:0005856,GO:0006508,GO:0008017,GO:0045765,GO:0045766,GO:0060716,GO:0061564,GO:0140253" syncytium formation by plasma membrane fusion|positive regulation of endothelial cell proliferation|actin binding|metallocarboxypeptidase activity|protein binding|extracellular region|cytoplasm|cytoskeleton|proteolysis|microtubule binding|regulation of angiogenesis|positive regulation of angiogenesis|labyrinthine layer blood vessel development|axon development|cell-cell fusion VASN 13.07566138 18.26920743 7.882115332 0.431442654 -1.212759283 0.35226988 1 0.328576316 0.147868363 114990 vasorin "GO:0005515,GO:0005615,GO:0005739,GO:0005765,GO:0005886,GO:0009986,GO:0010719,GO:0016021,GO:0030512,GO:0031012,GO:0045296,GO:0050431,GO:0070062,GO:0071456,GO:0071461" protein binding|extracellular space|mitochondrion|lysosomal membrane|plasma membrane|cell surface|negative regulation of epithelial to mesenchymal transition|integral component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|cadherin binding|transforming growth factor beta binding|extracellular exosome|cellular response to hypoxia|cellular response to redox state VASP 1882.311303 1917.251824 1847.370781 0.963551453 -0.053566387 0.870037127 1 42.92751602 43.14461514 7408 vasodilator stimulated phosphoprotein "GO:0001843,GO:0003779,GO:0005515,GO:0005522,GO:0005829,GO:0005886,GO:0005923,GO:0005925,GO:0007411,GO:0008154,GO:0015629,GO:0017124,GO:0030036,GO:0030838,GO:0031258,GO:0031527,GO:0034329,GO:0045296,GO:0051289,GO:0070062" neural tube closure|actin binding|protein binding|profilin binding|cytosol|plasma membrane|bicellular tight junction|focal adhesion|axon guidance|actin polymerization or depolymerization|actin cytoskeleton|SH3 domain binding|actin cytoskeleton organization|positive regulation of actin filament polymerization|lamellipodium membrane|filopodium membrane|cell junction assembly|cadherin binding|protein homotetramerization|extracellular exosome "hsa04015,hsa04022,hsa04510,hsa04530,hsa04611,hsa04666,hsa04670" Rap1 signaling pathway|cGMP-PKG signaling pathway|Focal adhesion|Tight junction|Platelet activation|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration VAT1 12687.31056 12297.20651 13077.4146 1.063445961 0.088746725 0.796553922 1 230.7558829 255.9670939 10493 vesicle amine transport 1 "GO:0005515,GO:0005576,GO:0005741,GO:0008270,GO:0010637,GO:0016021,GO:0016491,GO:0035578,GO:0043312,GO:0055114,GO:0070062" protein binding|extracellular region|mitochondrial outer membrane|zinc ion binding|negative regulation of mitochondrial fusion|integral component of membrane|oxidoreductase activity|azurophil granule lumen|neutrophil degranulation|oxidation-reduction process|extracellular exosome VAT1L 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.040678401 0.082378787 57687 vesicle amine transport 1 like "GO:0005515,GO:0008270,GO:0016491,GO:0055114" protein binding|zinc ion binding|oxidoreductase activity|oxidation-reduction process VAV2 2921.503981 3111.854999 2731.152963 0.87766074 -0.188264721 0.554372118 1 23.53008028 21.54100743 7410 vav guanine nucleotide exchange factor 2 "GO:0001525,GO:0001784,GO:0005085,GO:0005154,GO:0005515,GO:0005829,GO:0005886,GO:0007165,GO:0007186,GO:0007264,GO:0008361,GO:0016477,GO:0030032,GO:0030168,GO:0038095,GO:0038096,GO:0043065,GO:0043087,GO:0043552,GO:0046872,GO:0048010,GO:0048013,GO:0051056" angiogenesis|phosphotyrosine residue binding|guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|protein binding|cytosol|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|regulation of cell size|cell migration|lamellipodium assembly|platelet activation|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of apoptotic process|regulation of GTPase activity|positive regulation of phosphatidylinositol 3-kinase activity|metal ion binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|regulation of small GTPase mediated signal transduction "hsa04015,hsa04024,hsa04062,hsa04510,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04670,hsa04810,hsa05135,hsa05205" Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Yersinia infection|Proteoglycans in cancer VAX2 114.1934329 94.39090506 133.9959607 1.419585505 0.505469749 0.438726138 1 1.120883083 1.659731363 25806 ventral anterior homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001162,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0007398,GO:0007409,GO:0007417,GO:0007601,GO:0009950,GO:0016055,GO:0030182,GO:0030900,GO:0031490,GO:0048048,GO:0060041,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|ectoderm development|axonogenesis|central nervous system development|visual perception|dorsal/ventral axis specification|Wnt signaling pathway|neuron differentiation|forebrain development|chromatin DNA binding|embryonic eye morphogenesis|retina development in camera-type eye|sequence-specific double-stranded DNA binding" VBP1 1426.348892 1292.038948 1560.658836 1.207903863 0.272505635 0.414386368 1 32.01429289 40.33594291 7411 VHL binding protein 1 "GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006457,GO:0007017,GO:0007021,GO:0015631,GO:0016272,GO:0043231,GO:0051082,GO:1905907" amyloid-beta binding|protein binding|nucleus|cytoplasm|cytosol|polysome|protein folding|microtubule-based process|tubulin complex assembly|tubulin binding|prefoldin complex|intracellular membrane-bounded organelle|unfolded protein binding|negative regulation of amyloid fibril formation VCAN 7528.045916 6812.38446 8243.707373 1.210106009 0.275133438 0.403358374 1 27.94841962 35.27740269 1462 versican "GO:0001501,GO:0001649,GO:0001750,GO:0005509,GO:0005515,GO:0005539,GO:0005540,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0007155,GO:0007275,GO:0007417,GO:0008037,GO:0016020,GO:0030021,GO:0030198,GO:0030206,GO:0030207,GO:0030208,GO:0030246,GO:0031012,GO:0033165,GO:0043202,GO:0043687,GO:0044267,GO:0062023" skeletal system development|osteoblast differentiation|photoreceptor outer segment|calcium ion binding|protein binding|glycosaminoglycan binding|hyaluronic acid binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|cell adhesion|multicellular organism development|central nervous system development|cell recognition|membrane|extracellular matrix structural constituent conferring compression resistance|extracellular matrix organization|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|carbohydrate binding|extracellular matrix|interphotoreceptor matrix|lysosomal lumen|post-translational protein modification|cellular protein metabolic process|collagen-containing extracellular matrix hsa04514 Cell adhesion molecules VCL 10411.57095 10493.62976 10329.51214 0.984360263 -0.022741676 0.946575065 1 96.68279569 99.27027002 7414 vinculin "GO:0002009,GO:0002102,GO:0002162,GO:0002576,GO:0003779,GO:0005198,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0005911,GO:0005912,GO:0005916,GO:0005925,GO:0006936,GO:0007155,GO:0007160,GO:0008013,GO:0030032,GO:0030055,GO:0030336,GO:0031625,GO:0032991,GO:0034333,GO:0034394,GO:0034774,GO:0035580,GO:0035633,GO:0042383,GO:0043034,GO:0043297,GO:0043312,GO:0044291,GO:0045294,GO:0045296,GO:0048675,GO:0051893,GO:0070062,GO:0070527,GO:0090136,GO:1903140,GO:1903561,GO:1904702,GO:1904813" morphogenesis of an epithelium|podosome|dystroglycan binding|platelet degranulation|actin binding|structural molecule activity|protein binding|extracellular region|cytosol|cytoskeleton|cell-cell junction|adherens junction|fascia adherens|focal adhesion|muscle contraction|cell adhesion|cell-matrix adhesion|beta-catenin binding|lamellipodium assembly|cell-substrate junction|negative regulation of cell migration|ubiquitin protein ligase binding|protein-containing complex|adherens junction assembly|protein localization to cell surface|secretory granule lumen|specific granule lumen|maintenance of blood-brain barrier|sarcolemma|costamere|apical junction assembly|neutrophil degranulation|cell-cell contact zone|alpha-catenin binding|cadherin binding|axon extension|regulation of focal adhesion assembly|extracellular exosome|platelet aggregation|epithelial cell-cell adhesion|regulation of establishment of endothelial barrier|extracellular vesicle|regulation of protein localization to adherens junction|ficolin-1-rich granule lumen "hsa04510,hsa04520,hsa04670,hsa04810,hsa05100,hsa05131,hsa05146" Focal adhesion|Adherens junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Amoebiasis VCP 13334.4984 14275.3557 12393.6411 0.868184398 -0.203926598 0.555480013 1 167.1281566 151.348294 7415 valosin containing protein "GO:0000502,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0006281,GO:0006302,GO:0006457,GO:0006734,GO:0006888,GO:0006914,GO:0006919,GO:0006974,GO:0008289,GO:0010494,GO:0010498,GO:0010918,GO:0016236,GO:0016567,GO:0016579,GO:0016887,GO:0019079,GO:0019903,GO:0019904,GO:0019985,GO:0030433,GO:0030968,GO:0030970,GO:0031334,GO:0031593,GO:0031625,GO:0032436,GO:0032510,GO:0032991,GO:0034098,GO:0034605,GO:0034774,GO:0035578,GO:0035617,GO:0035800,GO:0035861,GO:0036297,GO:0036435,GO:0036503,GO:0036513,GO:0042288,GO:0042802,GO:0042981,GO:0043161,GO:0043231,GO:0043312,GO:0043531,GO:0044389,GO:0045184,GO:0045732,GO:0045879,GO:0046034,GO:0048471,GO:0050807,GO:0051228,GO:0055085,GO:0061857,GO:0070062,GO:0070842,GO:0070987,GO:0071712,GO:0072389,GO:0090263,GO:0097352,GO:0098978,GO:0106300,GO:1903006,GO:1903007,GO:1903715,GO:1903843,GO:1903862,GO:1904288,GO:1904813,GO:1904949,GO:1905634,GO:1990381,GO:1990730,GO:2000158,GO:2001171" "proteasome complex|RNA binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cytosol|DNA repair|double-strand break repair|protein folding|NADH metabolic process|endoplasmic reticulum to Golgi vesicle-mediated transport|autophagy|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|lipid binding|cytoplasmic stress granule|proteasomal protein catabolic process|positive regulation of mitochondrial membrane potential|macroautophagy|protein ubiquitination|protein deubiquitination|ATPase activity|viral genome replication|protein phosphatase binding|protein domain specific binding|translesion synthesis|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|positive regulation of protein-containing complex assembly|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|endosome to lysosome transport via multivesicular body sorting pathway|protein-containing complex|VCP-NPL4-UFD1 AAA ATPase complex|cellular response to heat|secretory granule lumen|azurophil granule lumen|stress granule disassembly|deubiquitinase activator activity|site of double-strand break|interstrand cross-link repair|K48-linked polyubiquitin modification-dependent protein binding|ERAD pathway|Derlin-1 retrotranslocation complex|MHC class I protein binding|identical protein binding|regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|neutrophil degranulation|ADP binding|ubiquitin-like protein ligase binding|establishment of protein localization|positive regulation of protein catabolic process|negative regulation of smoothened signaling pathway|ATP metabolic process|perinuclear region of cytoplasm|regulation of synapse organization|mitotic spindle disassembly|transmembrane transport|endoplasmic reticulum stress-induced pre-emptive quality control|extracellular exosome|aggresome assembly|error-free translesion synthesis|ER-associated misfolded protein catabolic process|flavin adenine dinucleotide catabolic process|positive regulation of canonical Wnt signaling pathway|autophagosome maturation|glutamatergic synapse|protein-DNA covalent cross-linking repair|positive regulation of protein K63-linked deubiquitination|positive regulation of Lys63-specific deubiquitinase activity|regulation of aerobic respiration|cellular response to arsenite ion|positive regulation of oxidative phosphorylation|BAT3 complex binding|ficolin-1-rich granule lumen|ATPase complex|regulation of protein localization to chromatin|ubiquitin-specific protease binding|VCP-NSFL1C complex|positive regulation of ubiquitin-specific protease activity|positive regulation of ATP biosynthetic process" "hsa04141,hsa05014,hsa05022,hsa05134" Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Legionellosis VCPIP1 1174.90679 1177.348923 1172.464656 0.99585147 -0.005997513 0.988860101 1 5.989209474 6.221283629 80124 valosin containing protein interacting protein 1 "GO:0000278,GO:0004843,GO:0005634,GO:0005737,GO:0005788,GO:0005795,GO:0006974,GO:0008234,GO:0016320,GO:0016567,GO:0016579,GO:0018215,GO:0035871,GO:0071108,GO:0090168,GO:0106300,GO:1905634" mitotic cell cycle|thiol-dependent ubiquitin-specific protease activity|nucleus|cytoplasm|endoplasmic reticulum lumen|Golgi stack|cellular response to DNA damage stimulus|cysteine-type peptidase activity|endoplasmic reticulum membrane fusion|protein ubiquitination|protein deubiquitination|protein phosphopantetheinylation|protein K11-linked deubiquitination|protein K48-linked deubiquitination|Golgi reassembly|protein-DNA covalent cross-linking repair|regulation of protein localization to chromatin VCPKMT 123.058091 127.884452 118.23173 0.924519972 -0.113223609 0.869786344 1 0.750596401 0.723833543 79609 valosin containing protein lysine methyltransferase "GO:0005515,GO:0005737,GO:0005829,GO:0006479,GO:0016279,GO:0018022,GO:0018023,GO:0032780,GO:0032991,GO:0051117" protein binding|cytoplasm|cytosol|protein methylation|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|peptidyl-lysine trimethylation|negative regulation of ATPase activity|protein-containing complex|ATPase binding VDAC1 4584.591475 4692.141442 4477.041509 0.954157406 -0.067700809 0.8329243 1 102.8746369 102.3868709 7416 voltage dependent anion channel 1 "GO:0001662,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005757,GO:0005886,GO:0006090,GO:0006820,GO:0006851,GO:0006915,GO:0007270,GO:0007612,GO:0008021,GO:0008308,GO:0015288,GO:0015485,GO:0015698,GO:0016020,GO:0016032,GO:0016236,GO:0019901,GO:0030855,GO:0031210,GO:0031966,GO:0042645,GO:0042802,GO:0043066,GO:0044325,GO:0044877,GO:0045121,GO:0046930,GO:0070062,GO:0097001,GO:0098656,GO:0110099,GO:1901526,GO:1903146,GO:2000378" behavioral fear response|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|mitochondrial permeability transition pore complex|plasma membrane|pyruvate metabolic process|anion transport|mitochondrial calcium ion transmembrane transport|apoptotic process|neuron-neuron synaptic transmission|learning|synaptic vesicle|voltage-gated anion channel activity|porin activity|cholesterol binding|inorganic anion transport|membrane|viral process|macroautophagy|protein kinase binding|epithelial cell differentiation|phosphatidylcholine binding|mitochondrial membrane|mitochondrial nucleoid|identical protein binding|negative regulation of apoptotic process|ion channel binding|protein-containing complex binding|membrane raft|pore complex|extracellular exosome|ceramide binding|anion transmembrane transport|negative regulation of calcium import into the mitochondrion|positive regulation of mitophagy|regulation of autophagy of mitochondrion|negative regulation of reactive oxygen species metabolic process "hsa04020,hsa04022,hsa04217,hsa04218,hsa04621,hsa04979,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05131,hsa05164,hsa05166" Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Cholesterol metabolism|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Influenza A|Human T-cell leukemia virus 1 infection VDAC2 3226.943869 3381.833287 3072.054451 0.90839914 -0.138601754 0.663391978 1 85.12819363 80.66145698 7417 voltage dependent anion channel 2 "GO:0000166,GO:0001669,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0006820,GO:0007339,GO:0008021,GO:0008308,GO:0015288,GO:0015485,GO:0015698,GO:0016020,GO:0031210,GO:0031966,GO:0032272,GO:0042645,GO:0046930,GO:0097001,GO:0097345,GO:0098656,GO:2001243" nucleotide binding|acrosomal vesicle|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|anion transport|binding of sperm to zona pellucida|synaptic vesicle|voltage-gated anion channel activity|porin activity|cholesterol binding|inorganic anion transport|membrane|phosphatidylcholine binding|mitochondrial membrane|negative regulation of protein polymerization|mitochondrial nucleoid|pore complex|ceramide binding|mitochondrial outer membrane permeabilization|anion transmembrane transport|negative regulation of intrinsic apoptotic signaling pathway "hsa04020,hsa04022,hsa04216,hsa04217,hsa04218,hsa04621,hsa04979,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05166" Calcium signaling pathway|cGMP-PKG signaling pathway|Ferroptosis|Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Cholesterol metabolism|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Human T-cell leukemia virus 1 infection VDAC3 1245.517737 1356.99613 1134.039343 0.835698289 -0.258945913 0.44683012 1 40.98215073 35.7240089 7419 voltage dependent anion channel 3 "GO:0000166,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0008308,GO:0015288,GO:0015698,GO:0015853,GO:0016020,GO:0046930,GO:0070062,GO:0098656,GO:1902017" nucleotide binding|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|voltage-gated anion channel activity|porin activity|inorganic anion transport|adenine transport|membrane|pore complex|extracellular exosome|anion transmembrane transport|regulation of cilium assembly "hsa04020,hsa04022,hsa04216,hsa04217,hsa04218,hsa04621,hsa04979,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05161,hsa05166,hsa05203" Calcium signaling pathway|cGMP-PKG signaling pathway|Ferroptosis|Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Cholesterol metabolism|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Hepatitis B|Human T-cell leukemia virus 1 infection|Viral carcinogenesis VDR 358.4672548 426.2815067 290.6530029 0.681833479 -0.552508655 0.217419473 1 4.211793696 2.995444946 7421 vitamin D receptor "GO:0000122,GO:0000785,GO:0000902,GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006367,GO:0007275,GO:0008270,GO:0008285,GO:0010628,GO:0010629,GO:0010839,GO:0010980,GO:0030154,GO:0038183,GO:0038186,GO:0042359,GO:0043235,GO:0045618,GO:0045892,GO:0045944,GO:0046697,GO:0046965,GO:0060558,GO:0070561,GO:0070644,GO:0090575,GO:1902098,GO:1902121" "negative regulation of transcription by RNA polymerase II|chromatin|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|transcription initiation from RNA polymerase II promoter|multicellular organism development|zinc ion binding|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|negative regulation of keratinocyte proliferation|positive regulation of vitamin D 24-hydroxylase activity|cell differentiation|bile acid signaling pathway|lithocholic acid receptor activity|vitamin D metabolic process|receptor complex|positive regulation of keratinocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|decidualization|retinoid X receptor binding|regulation of calcidiol 1-monooxygenase activity|vitamin D receptor signaling pathway|vitamin D response element binding|RNA polymerase II transcription regulator complex|calcitriol binding|lithocholic acid binding" "hsa04928,hsa04961,hsa04978,hsa05152" "Parathyroid hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Mineral absorption|Tuberculosis" ThyrH_rcpt VEGFA 6450.575899 8389.626035 4511.525763 0.53775052 -0.89499108 0.00637124 0.31983627 114.0072342 63.94832576 7422 vascular endothelial growth factor A "GO:0000122,GO:0001525,GO:0001541,GO:0001569,GO:0001570,GO:0001666,GO:0001701,GO:0001822,GO:0001934,GO:0001938,GO:0001968,GO:0002040,GO:0002042,GO:0002052,GO:0002053,GO:0002092,GO:0002576,GO:0002687,GO:0003007,GO:0003151,GO:0003169,GO:0005125,GO:0005161,GO:0005172,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005912,GO:0006357,GO:0007399,GO:0007498,GO:0007595,GO:0008083,GO:0008201,GO:0008284,GO:0008360,GO:0009986,GO:0010595,GO:0010628,GO:0010629,GO:0010749,GO:0016020,GO:0019221,GO:0030141,GO:0030224,GO:0030225,GO:0030324,GO:0030335,GO:0030855,GO:0031012,GO:0031077,GO:0031093,GO:0031334,GO:0031954,GO:0032147,GO:0032793,GO:0033138,GO:0035148,GO:0035767,GO:0035924,GO:0036303,GO:0036324,GO:0038033,GO:0038084,GO:0038091,GO:0038190,GO:0042056,GO:0042462,GO:0042531,GO:0042802,GO:0042803,GO:0043066,GO:0043117,GO:0043129,GO:0043154,GO:0043183,GO:0043184,GO:0043406,GO:0043536,GO:0045766,GO:0045785,GO:0045944,GO:0048010,GO:0048018,GO:0048469,GO:0048593,GO:0048739,GO:0048754,GO:0048842,GO:0048844,GO:0050679,GO:0050731,GO:0050840,GO:0050918,GO:0050927,GO:0050930,GO:0051272,GO:0051781,GO:0051894,GO:0060319,GO:0060749,GO:0060754,GO:0060948,GO:0060982,GO:0061042,GO:0061418,GO:0061419,GO:0071456,GO:0071542,GO:0071679,GO:0090037,GO:0090050,GO:0090190,GO:0090259,GO:0097475,GO:0097533,GO:0120162,GO:1900086,GO:1900745,GO:1901165,GO:1901727,GO:1902336,GO:1903141,GO:1903392,GO:1903572,GO:1903589,GO:1903672,GO:1905604,GO:2000048" negative regulation of transcription by RNA polymerase II|angiogenesis|ovarian follicle development|branching involved in blood vessel morphogenesis|vasculogenesis|response to hypoxia|in utero embryonic development|kidney development|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|fibronectin binding|sprouting angiogenesis|cell migration involved in sprouting angiogenesis|positive regulation of neuroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of receptor internalization|platelet degranulation|positive regulation of leukocyte migration|heart morphogenesis|outflow tract morphogenesis|coronary vein morphogenesis|cytokine activity|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|adherens junction|regulation of transcription by RNA polymerase II|nervous system development|mesoderm development|lactation|growth factor activity|heparin binding|positive regulation of cell population proliferation|regulation of cell shape|cell surface|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|regulation of nitric oxide mediated signal transduction|membrane|cytokine-mediated signaling pathway|secretory granule|monocyte differentiation|macrophage differentiation|lung development|positive regulation of cell migration|epithelial cell differentiation|extracellular matrix|post-embryonic camera-type eye development|platelet alpha granule lumen|positive regulation of protein-containing complex assembly|positive regulation of protein autophosphorylation|activation of protein kinase activity|positive regulation of CREB transcription factor activity|positive regulation of peptidyl-serine phosphorylation|tube formation|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|lymph vessel morphogenesis|vascular endothelial growth factor receptor-2 signaling pathway|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|vascular endothelial growth factor signaling pathway|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|VEGF-activated neuropilin signaling pathway|chemoattractant activity|eye photoreceptor cell development|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|positive regulation of vascular permeability|surfactant homeostasis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|positive regulation of MAP kinase activity|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of transcription by RNA polymerase II|vascular endothelial growth factor receptor signaling pathway|receptor ligand activity|cell maturation|camera-type eye morphogenesis|cardiac muscle fiber development|branching morphogenesis of an epithelial tube|positive regulation of axon extension involved in axon guidance|artery morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|extracellular matrix binding|positive chemotaxis|positive regulation of positive chemotaxis|induction of positive chemotaxis|positive regulation of cellular component movement|positive regulation of cell division|positive regulation of focal adhesion assembly|primitive erythrocyte differentiation|mammary gland alveolus development|positive regulation of mast cell chemotaxis|cardiac vascular smooth muscle cell development|coronary artery morphogenesis|vascular wound healing|regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|dopaminergic neuron differentiation|commissural neuron axon guidance|positive regulation of protein kinase C signaling|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of branching involved in ureteric bud morphogenesis|regulation of retinal ganglion cell axon guidance|motor neuron migration|cellular stress response to acid chemical|positive regulation of cold-induced thermogenesis|positive regulation of peptidyl-tyrosine autophosphorylation|positive regulation of p38MAPK cascade|positive regulation of trophoblast cell migration|positive regulation of histone deacetylase activity|positive regulation of retinal ganglion cell axon guidance|negative regulation of establishment of endothelial barrier|negative regulation of adherens junction organization|positive regulation of protein kinase D signaling|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of sprouting angiogenesis|negative regulation of blood-brain barrier permeability|negative regulation of cell-cell adhesion mediated by cadherin "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04066,hsa04151,hsa04370,hsa04510,hsa04926,hsa04933,hsa05163,hsa05165,hsa05167,hsa05200,hsa05205,hsa05206,hsa05211,hsa05212,hsa05219,hsa05323,hsa05418" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|VEGF signaling pathway|Focal adhesion|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Renal cell carcinoma|Pancreatic cancer|Bladder cancer|Rheumatoid arthritis|Fluid shear stress and atherosclerosis VEGFB 1414.648444 1435.147739 1394.149149 0.971432495 -0.041814348 0.902413545 1 40.2687923 40.80347598 7423 vascular endothelial growth factor B "GO:0001666,GO:0001934,GO:0001938,GO:0002040,GO:0002576,GO:0005172,GO:0005515,GO:0005576,GO:0005615,GO:0006493,GO:0008083,GO:0008201,GO:0016020,GO:0031093,GO:0038084,GO:0042056,GO:0042493,GO:0042802,GO:0043183,GO:0045766,GO:0048010,GO:0050918,GO:0050930,GO:0051781,GO:0060048,GO:0060754,GO:0060976" response to hypoxia|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|sprouting angiogenesis|platelet degranulation|vascular endothelial growth factor receptor binding|protein binding|extracellular region|extracellular space|protein O-linked glycosylation|growth factor activity|heparin binding|membrane|platelet alpha granule lumen|vascular endothelial growth factor signaling pathway|chemoattractant activity|response to drug|identical protein binding|vascular endothelial growth factor receptor 1 binding|positive regulation of angiogenesis|vascular endothelial growth factor receptor signaling pathway|positive chemotaxis|induction of positive chemotaxis|positive regulation of cell division|cardiac muscle contraction|positive regulation of mast cell chemotaxis|coronary vasculature development "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04510,hsa04926,hsa04933,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer VEGFC 1274.241584 1333.652142 1214.831026 0.910905465 -0.134626757 0.692510894 1 29.90029932 28.4095774 7424 vascular endothelial growth factor C "GO:0001666,GO:0001934,GO:0001938,GO:0002040,GO:0002052,GO:0002576,GO:0005172,GO:0005515,GO:0005576,GO:0005615,GO:0006929,GO:0007165,GO:0008083,GO:0008284,GO:0009887,GO:0016020,GO:0016331,GO:0030947,GO:0031093,GO:0031954,GO:0038084,GO:0042056,GO:0042493,GO:0043185,GO:0043536,GO:0045668,GO:0045766,GO:0045776,GO:0045860,GO:0048010,GO:0050714,GO:0050918,GO:0050930,GO:0051781,GO:0060754,GO:1901492,GO:1902462,GO:1990830" response to hypoxia|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|sprouting angiogenesis|positive regulation of neuroblast proliferation|platelet degranulation|vascular endothelial growth factor receptor binding|protein binding|extracellular region|extracellular space|substrate-dependent cell migration|signal transduction|growth factor activity|positive regulation of cell population proliferation|animal organ morphogenesis|membrane|morphogenesis of embryonic epithelium|regulation of vascular endothelial growth factor receptor signaling pathway|platelet alpha granule lumen|positive regulation of protein autophosphorylation|vascular endothelial growth factor signaling pathway|chemoattractant activity|response to drug|vascular endothelial growth factor receptor 3 binding|positive regulation of blood vessel endothelial cell migration|negative regulation of osteoblast differentiation|positive regulation of angiogenesis|negative regulation of blood pressure|positive regulation of protein kinase activity|vascular endothelial growth factor receptor signaling pathway|positive regulation of protein secretion|positive chemotaxis|induction of positive chemotaxis|positive regulation of cell division|positive regulation of mast cell chemotaxis|positive regulation of lymphangiogenesis|positive regulation of mesenchymal stem cell proliferation|cellular response to leukemia inhibitory factor "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04510,hsa04668,hsa04926,hsa04933,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|TNF signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer VEPH1 194.2467856 178.6322504 209.8613207 1.174823248 0.23244372 0.674662111 1 1.539930776 1.887077169 79674 ventricular zone expressed PH domain containing 1 "GO:0005515,GO:0005886,GO:0009966,GO:0010314,GO:0030512,GO:0060392" protein binding|plasma membrane|regulation of signal transduction|phosphatidylinositol-5-phosphate binding|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of SMAD protein signal transduction VEZF1 2327.155219 2321.2043 2333.106138 1.005127441 0.007378434 0.983087196 1 24.1546762 25.3243484 7716 vascular endothelial zinc finger 1 "GO:0000977,GO:0000981,GO:0001228,GO:0001525,GO:0001885,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006968,GO:0045603,GO:0045944,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|endothelial cell development|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cellular defense response|positive regulation of endothelial cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 VEZT 1172.328822 1304.218419 1040.439224 0.797749218 -0.325992806 0.342482045 1 10.06461404 8.37489637 55591 "vezatin, adherens junctions transmembrane protein" "GO:0001669,GO:0002142,GO:0005654,GO:0005829,GO:0005912,GO:0016021,GO:0017022,GO:0060171,GO:0098609" acrosomal vesicle|stereocilia ankle link complex|nucleoplasm|cytosol|adherens junction|integral component of membrane|myosin binding|stereocilium membrane|cell-cell adhesion VGF 58.15484892 69.01700585 47.29269199 0.68523245 -0.545334622 0.506457412 1 1.140818495 0.815399431 7425 VGF nerve growth factor inducible "GO:0001541,GO:0002021,GO:0003674,GO:0005179,GO:0005184,GO:0005615,GO:0005788,GO:0005794,GO:0006091,GO:0007165,GO:0008083,GO:0009409,GO:0019953,GO:0030073,GO:0030133,GO:0031410,GO:0032868,GO:0033500,GO:0042593,GO:0042742,GO:0043231,GO:0043687,GO:0044267,GO:0048167,GO:0051591" ovarian follicle development|response to dietary excess|molecular_function|hormone activity|neuropeptide hormone activity|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|generation of precursor metabolites and energy|signal transduction|growth factor activity|response to cold|sexual reproduction|insulin secretion|transport vesicle|cytoplasmic vesicle|response to insulin|carbohydrate homeostasis|glucose homeostasis|defense response to bacterium|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process|regulation of synaptic plasticity|response to cAMP VGLL3 183.0377326 153.2583512 212.817114 1.388616753 0.473648482 0.394901518 1 0.669137485 0.969200635 389136 vestigial like family member 3 "GO:0005634,GO:0006357" nucleus|regulation of transcription by RNA polymerase II VGLL4 1264.235039 1390.489677 1137.980401 0.818402625 -0.289117323 0.394496681 1 13.35293833 11.39881714 9686 vestigial like family member 4 "GO:0001223,GO:0005515,GO:0005634,GO:0030178,GO:0030308,GO:0035331,GO:0045892,GO:0060044,GO:1903364" "transcription coactivator binding|protein binding|nucleus|negative regulation of Wnt signaling pathway|negative regulation of cell growth|negative regulation of hippo signaling|negative regulation of transcription, DNA-templated|negative regulation of cardiac muscle cell proliferation|positive regulation of cellular protein catabolic process" VHL 2903.889471 2917.998409 2889.780534 0.990329715 -0.014019166 0.966028004 1 31.62557786 32.66887731 7428 von Hippel-Lindau tumor suppressor "GO:0000122,GO:0000902,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005783,GO:0005829,GO:0006355,GO:0006508,GO:0008134,GO:0008285,GO:0010629,GO:0016020,GO:0016567,GO:0019899,GO:0043066,GO:0043687,GO:0045597,GO:0045893,GO:0046426,GO:0050821,GO:0061418,GO:0061428,GO:1990756" "negative regulation of transcription by RNA polymerase II|cell morphogenesis|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|mitochondrion|endoplasmic reticulum|cytosol|regulation of transcription, DNA-templated|proteolysis|transcription factor binding|negative regulation of cell population proliferation|negative regulation of gene expression|membrane|protein ubiquitination|enzyme binding|negative regulation of apoptotic process|post-translational protein modification|positive regulation of cell differentiation|positive regulation of transcription, DNA-templated|negative regulation of receptor signaling pathway via JAK-STAT|protein stabilization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|ubiquitin ligase-substrate adaptor activity" "hsa04066,hsa04120,hsa05200,hsa05211" HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Pathways in cancer|Renal cell carcinoma VILL 116.849589 107.5853326 126.1138453 1.172221549 0.229245264 0.73062787 1 1.674498328 2.047436065 50853 villin like "GO:0005200,GO:0005546,GO:0005737,GO:0008154,GO:0015629,GO:0051014,GO:0051015,GO:0051016" "structural constituent of cytoskeleton|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|actin polymerization or depolymerization|actin cytoskeleton|actin filament severing|actin filament binding|barbed-end actin filament capping" VIM 81329.17884 83527.83133 79130.52635 0.947355212 -0.078022628 0.867626415 1 1961.237825 1938.023501 7431 vimentin "GO:0003725,GO:0005200,GO:0005212,GO:0005515,GO:0005737,GO:0005777,GO:0005829,GO:0005844,GO:0005856,GO:0005882,GO:0005886,GO:0005925,GO:0010977,GO:0014002,GO:0016032,GO:0016363,GO:0019221,GO:0019904,GO:0030049,GO:0031252,GO:0032967,GO:0042802,GO:0043005,GO:0043488,GO:0045109,GO:0045111,GO:0045335,GO:0045727,GO:0060020,GO:0060395,GO:0070062,GO:0070307,GO:0071222,GO:0071225,GO:0071346,GO:0097110,GO:1990254,GO:1990904" double-stranded RNA binding|structural constituent of cytoskeleton|structural constituent of eye lens|protein binding|cytoplasm|peroxisome|cytosol|polysome|cytoskeleton|intermediate filament|plasma membrane|focal adhesion|negative regulation of neuron projection development|astrocyte development|viral process|nuclear matrix|cytokine-mediated signaling pathway|protein domain specific binding|muscle filament sliding|cell leading edge|positive regulation of collagen biosynthetic process|identical protein binding|neuron projection|regulation of mRNA stability|intermediate filament organization|intermediate filament cytoskeleton|phagocytic vesicle|positive regulation of translation|Bergmann glial cell differentiation|SMAD protein signal transduction|extracellular exosome|lens fiber cell development|cellular response to lipopolysaccharide|cellular response to muramyl dipeptide|cellular response to interferon-gamma|scaffold protein binding|keratin filament binding|ribonucleoprotein complex "hsa05169,hsa05206" Epstein-Barr virus infection|MicroRNAs in cancer VIPAS39 515.3064057 573.4501221 457.1626893 0.79721439 -0.326960343 0.420892932 1 8.692973863 7.228687207 63894 "VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog" "GO:0005515,GO:0005737,GO:0005769,GO:0005770,GO:0005794,GO:0006886,GO:0007034,GO:0007283,GO:0008333,GO:0017185,GO:0030154,GO:0030897,GO:0032963,GO:0044877,GO:0055037,GO:0097352" protein binding|cytoplasm|early endosome|late endosome|Golgi apparatus|intracellular protein transport|vacuolar transport|spermatogenesis|endosome to lysosome transport|peptidyl-lysine hydroxylation|cell differentiation|HOPS complex|collagen metabolic process|protein-containing complex binding|recycling endosome|autophagosome maturation VIPR1 29.85484801 20.29911937 39.41057666 1.941491941 0.957165719 0.338028427 1 0.158825704 0.321641673 7433 vasoactive intestinal peptide receptor 1 "GO:0004999,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007187,GO:0007188,GO:0008284,GO:0008528,GO:0017046,GO:0043235" "vasoactive intestinal polypeptide receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|positive regulation of cell population proliferation|G protein-coupled peptide receptor activity|peptide hormone binding|receptor complex" hsa04080 Neuroactive ligand-receptor interaction VIRMA 3205.960606 3126.064383 3285.856829 1.051116173 0.071922129 0.821829666 1 23.49022743 25.75454428 25962 vir like m6A methyltransferase associated "GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0006397,GO:0007275,GO:0008380,GO:0016604,GO:0016607,GO:0036396,GO:0080009,GO:0110104" RNA binding|protein binding|nucleoplasm|cytosol|mRNA processing|multicellular organism development|RNA splicing|nuclear body|nuclear speck|RNA N6-methyladenosine methyltransferase complex|mRNA methylation|mRNA alternative polyadenylation VKORC1 1553.625659 2045.136276 1062.115041 0.51933705 -0.945256942 0.004450824 0.246230463 112.0984173 60.72460766 79001 vitamin K epoxide reductase complex subunit 1 "GO:0005515,GO:0005783,GO:0005789,GO:0007596,GO:0010243,GO:0014070,GO:0016021,GO:0017144,GO:0017187,GO:0030193,GO:0042373,GO:0046677,GO:0047057,GO:0047058,GO:0048038,GO:0055114,GO:0060348" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|blood coagulation|response to organonitrogen compound|response to organic cyclic compound|integral component of membrane|drug metabolic process|peptidyl-glutamic acid carboxylation|regulation of blood coagulation|vitamin K metabolic process|response to antibiotic|vitamin-K-epoxide reductase (warfarin-sensitive) activity|vitamin-K-epoxide reductase (warfarin-insensitive) activity|quinone binding|oxidation-reduction process|bone development hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis VKORC1L1 939.3855405 972.3278177 906.4432632 0.932240389 -0.101226076 0.778507434 1 7.931224642 7.712303207 154807 vitamin K epoxide reductase complex subunit 1 like 1 "GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0017187,GO:0034599,GO:0042373,GO:0047057,GO:0048038,GO:0055114" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|peptidyl-glutamic acid carboxylation|cellular response to oxidative stress|vitamin K metabolic process|vitamin-K-epoxide reductase (warfarin-sensitive) activity|quinone binding|oxidation-reduction process hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis VLDLR 411.9075819 644.4970399 179.3181238 0.278229554 -1.845652423 3.14E-05 0.006448055 3.542982896 1.028225203 7436 very low density lipoprotein receptor "GO:0005041,GO:0005509,GO:0005515,GO:0005765,GO:0005886,GO:0005905,GO:0006869,GO:0006898,GO:0007165,GO:0007399,GO:0007411,GO:0007613,GO:0008203,GO:0016020,GO:0016021,GO:0021517,GO:0030229,GO:0032802,GO:0034185,GO:0034189,GO:0034361,GO:0034436,GO:0034447,GO:0038024,GO:0038025,GO:0038026,GO:0043235,GO:0045860,GO:0048306,GO:0048813,GO:1900006" low-density lipoprotein particle receptor activity|calcium ion binding|protein binding|lysosomal membrane|plasma membrane|clathrin-coated pit|lipid transport|receptor-mediated endocytosis|signal transduction|nervous system development|axon guidance|memory|cholesterol metabolic process|membrane|integral component of membrane|ventral spinal cord development|very-low-density lipoprotein particle receptor activity|low-density lipoprotein particle receptor catabolic process|apolipoprotein binding|very-low-density lipoprotein particle binding|very-low-density lipoprotein particle|glycoprotein transport|very-low-density lipoprotein particle clearance|cargo receptor activity|reelin receptor activity|reelin-mediated signaling pathway|receptor complex|positive regulation of protein kinase activity|calcium-dependent protein binding|dendrite morphogenesis|positive regulation of dendrite development hsa05017 Spinocerebellar ataxia VMA21 1277.378248 1312.338067 1242.418429 0.946721322 -0.078988281 0.817507193 1 12.83609375 12.67567129 203547 vacuolar ATPase assembly factor VMA21 "GO:0005515,GO:0005764,GO:0005773,GO:0005789,GO:0012507,GO:0016021,GO:0033116,GO:0043462,GO:0070072" protein binding|lysosome|vacuole|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly VMAC 60.49924376 60.8973581 60.10112941 0.98692507 -0.018987539 1 1 1.37689123 1.417423878 400673 vimentin type intermediate filament associated coiled-coil protein "GO:0005515,GO:0005737,GO:0045098" protein binding|cytoplasm|type III intermediate filament VMO1 49.9609723 47.70293051 52.21901408 1.094670988 0.130497322 0.900779572 1 3.291532895 3.758354464 284013 vitelline membrane outer layer 1 homolog "GO:0003674,GO:0008150,GO:0070062" molecular_function|biological_process|extracellular exosome VMP1 5682.444251 5249.352268 6115.536234 1.16500778 0.22033959 0.495639046 1 71.37212719 86.73080876 81671 vacuole membrane protein 1 "GO:0000045,GO:0000407,GO:0000421,GO:0005515,GO:0005730,GO:0005783,GO:0005886,GO:0006914,GO:0007030,GO:0007566,GO:0012505,GO:0016020,GO:0016021,GO:0033116,GO:0034329,GO:0098609" autophagosome assembly|phagophore assembly site|autophagosome membrane|protein binding|nucleolus|endoplasmic reticulum|plasma membrane|autophagy|Golgi organization|embryo implantation|endomembrane system|membrane|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|cell junction assembly|cell-cell adhesion hsa04140 Autophagy - animal VN1R1 10.00110192 10.14955968 9.852644165 0.970745971 -0.042834281 1 1 0.218647126 0.221393721 57191 vomeronasal 1 receptor 1 "GO:0005886,GO:0007186,GO:0008150,GO:0016021,GO:0016503,GO:0019236" plasma membrane|G protein-coupled receptor signaling pathway|biological_process|integral component of membrane|pheromone receptor activity|response to pheromone VNN1 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.066706384 0.013508867 8876 vanin 1 "GO:0002526,GO:0002544,GO:0005576,GO:0005886,GO:0006954,GO:0006979,GO:0015939,GO:0016021,GO:0017159,GO:0031225,GO:0033089,GO:0035577,GO:0043312,GO:0045087,GO:0098609,GO:1902176" acute inflammatory response|chronic inflammatory response|extracellular region|plasma membrane|inflammatory response|response to oxidative stress|pantothenate metabolic process|integral component of membrane|pantetheine hydrolase activity|anchored component of membrane|positive regulation of T cell differentiation in thymus|azurophil granule membrane|neutrophil degranulation|innate immune response|cell-cell adhesion|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway hsa00770 Pantothenate and CoA biosynthesis VOPP1 2414.506259 2432.849456 2396.163061 0.984920401 -0.021920961 0.946616488 1 21.5035327 22.09158501 81552 VOPP1 WW domain binding protein "GO:0005768,GO:0030659,GO:0031301" endosome|cytoplasmic vesicle membrane|integral component of organelle membrane VPS11 1029.845037 858.6527492 1201.037324 1.398746262 0.484134276 0.167562031 1 12.71199433 18.54678166 55823 VPS11 core subunit of CORVET and HOPS complexes "GO:0000166,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005776,GO:0006886,GO:0006904,GO:0006914,GO:0007032,GO:0007033,GO:0008333,GO:0016567,GO:0019904,GO:0019905,GO:0030136,GO:0030139,GO:0030674,GO:0030897,GO:0031647,GO:0031902,GO:0033147,GO:0034058,GO:0035542,GO:0046872,GO:0061630,GO:1902115,GO:1903364,GO:1903955,GO:2000643" nucleotide binding|protein binding|lysosome|lysosomal membrane|endosome|early endosome|late endosome|autophagosome|intracellular protein transport|vesicle docking involved in exocytosis|autophagy|endosome organization|vacuole organization|endosome to lysosome transport|protein ubiquitination|protein domain specific binding|syntaxin binding|clathrin-coated vesicle|endocytic vesicle|protein-macromolecule adaptor activity|HOPS complex|regulation of protein stability|late endosome membrane|negative regulation of intracellular estrogen receptor signaling pathway|endosomal vesicle fusion|regulation of SNARE complex assembly|metal ion binding|ubiquitin protein ligase activity|regulation of organelle assembly|positive regulation of cellular protein catabolic process|positive regulation of protein targeting to mitochondrion|positive regulation of early endosome to late endosome transport hsa05132 Salmonella infection VPS13A 1809.584091 1693.961511 1925.20667 1.13651146 0.184612231 0.570384628 1 5.18012164 6.140867219 23230 vacuolar protein sorting 13 homolog A "GO:0005515,GO:0005741,GO:0005765,GO:0005789,GO:0005794,GO:0005811,GO:0005829,GO:0006623,GO:0006895,GO:0006914,GO:0007399,GO:0007626,GO:0008104,GO:0010008,GO:0019898,GO:0030317,GO:0030382,GO:0031966,GO:0035176,GO:0045053,GO:0097225,GO:0099013,GO:1905146" protein binding|mitochondrial outer membrane|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|cytosol|protein targeting to vacuole|Golgi to endosome transport|autophagy|nervous system development|locomotory behavior|protein localization|endosome membrane|extrinsic component of membrane|flagellated sperm motility|sperm mitochondrion organization|mitochondrial membrane|social behavior|protein retention in Golgi apparatus|sperm midpiece|neuronal dense core vesicle lumen|lysosomal protein catabolic process VPS13B 3136.190425 3071.25676 3201.124089 1.042284752 0.059749475 0.851811822 1 10.60604938 11.53070758 157680 vacuolar protein sorting 13 homolog B GO:0015031 protein transport VPS13C 1466.454498 1373.235425 1559.673571 1.135765611 0.183665135 0.581370928 1 3.967683827 4.700474508 54832 vacuolar protein sorting 13 homolog C "GO:0005737,GO:0005741,GO:0005829,GO:0006623,GO:0006895,GO:0007005,GO:0019898,GO:0032127,GO:0032868,GO:0045053,GO:0070062,GO:1905090" cytoplasm|mitochondrial outer membrane|cytosol|protein targeting to vacuole|Golgi to endosome transport|mitochondrion organization|extrinsic component of membrane|dense core granule membrane|response to insulin|protein retention in Golgi apparatus|extracellular exosome|negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization VPS13D 2550.420292 2159.826301 2941.014283 1.361690189 0.445398499 0.162862093 1 6.687508878 9.498578356 55187 vacuolar protein sorting 13 homolog D "GO:0006623,GO:0007005,GO:0019898,GO:0045053,GO:0070062,GO:1901526" protein targeting to vacuole|mitochondrion organization|extrinsic component of membrane|protein retention in Golgi apparatus|extracellular exosome|positive regulation of mitophagy VPS16 781.1657324 730.7682972 831.5631676 1.137929999 0.186411811 0.615084727 1 13.66722166 16.22227333 64601 VPS16 core subunit of CORVET and HOPS complexes "GO:0003779,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005776,GO:0006886,GO:0007033,GO:0008333,GO:0016197,GO:0030136,GO:0030424,GO:0030897,GO:0031902,GO:0032889,GO:0035542,GO:0043025,GO:0051015,GO:0055037,GO:0097352" "actin binding|protein binding|lysosome|lysosomal membrane|endosome|early endosome|late endosome|autophagosome|intracellular protein transport|vacuole organization|endosome to lysosome transport|endosomal transport|clathrin-coated vesicle|axon|HOPS complex|late endosome membrane|regulation of vacuole fusion, non-autophagic|regulation of SNARE complex assembly|neuronal cell body|actin filament binding|recycling endosome|autophagosome maturation" hsa05132 Salmonella infection VPS18 736.8624846 867.787353 605.9376162 0.698255874 -0.518172291 0.165643597 1 10.94109237 7.968768529 57617 VPS18 core subunit of CORVET and HOPS complexes "GO:0003779,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005776,GO:0005884,GO:0006886,GO:0006904,GO:0006914,GO:0007032,GO:0007033,GO:0007040,GO:0008333,GO:0016567,GO:0019905,GO:0030123,GO:0030136,GO:0030674,GO:0030897,GO:0031902,GO:0033147,GO:0033263,GO:0035542,GO:0046718,GO:0046872,GO:0061630,GO:0098793,GO:0098978,GO:2000300" actin binding|protein binding|lysosome|lysosomal membrane|endosome|early endosome|late endosome|autophagosome|actin filament|intracellular protein transport|vesicle docking involved in exocytosis|autophagy|endosome organization|vacuole organization|lysosome organization|endosome to lysosome transport|protein ubiquitination|syntaxin binding|AP-3 adaptor complex|clathrin-coated vesicle|protein-macromolecule adaptor activity|HOPS complex|late endosome membrane|negative regulation of intracellular estrogen receptor signaling pathway|CORVET complex|regulation of SNARE complex assembly|viral entry into host cell|metal ion binding|ubiquitin protein ligase activity|presynapse|glutamatergic synapse|regulation of synaptic vesicle exocytosis hsa05132 Salmonella infection VPS25 1733.958985 1676.70726 1791.210709 1.068290662 0.095304232 0.771365305 1 78.05083423 86.97269175 84313 vacuolar protein sorting 25 homolog "GO:0000814,GO:0005198,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007175,GO:0010008,GO:0016197,GO:0016236,GO:0036258,GO:0042803,GO:0043328,GO:0047485,GO:0070062" ESCRT II complex|structural molecule activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|negative regulation of epidermal growth factor-activated receptor activity|endosome membrane|endosomal transport|macroautophagy|multivesicular body assembly|protein homodimerization activity|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein N-terminus binding|extracellular exosome hsa04144 Endocytosis VPS26A 2724.212573 2556.674084 2891.751063 1.131059716 0.1776751 0.577297015 1 30.09215035 35.50215268 9559 "VPS26, retromer complex component A" "GO:0005515,GO:0005764,GO:0005768,GO:0005769,GO:0005829,GO:0006886,GO:0010008,GO:0016055,GO:0016241,GO:0030904,GO:0030906,GO:0031982,GO:0042147,GO:0097422,GO:1990126" "protein binding|lysosome|endosome|early endosome|cytosol|intracellular protein transport|endosome membrane|Wnt signaling pathway|regulation of macroautophagy|retromer complex|retromer, cargo-selective complex|vesicle|retrograde transport, endosome to Golgi|tubular endosome|retrograde transport, endosome to plasma membrane" hsa04144 Endocytosis VPS26B 1126.076818 1173.289099 1078.864536 0.919521486 -0.121044809 0.727663821 1 13.87090424 13.30401068 112936 "VPS26, retromer complex component B" "GO:0005515,GO:0005768,GO:0005769,GO:0005770,GO:0005829,GO:0006886,GO:0016241,GO:0030904,GO:0030906,GO:0042147,GO:0045335,GO:0071346" "protein binding|endosome|early endosome|late endosome|cytosol|intracellular protein transport|regulation of macroautophagy|retromer complex|retromer, cargo-selective complex|retrograde transport, endosome to Golgi|phagocytic vesicle|cellular response to interferon-gamma" hsa04144 Endocytosis VPS26C 1097.336887 1027.13544 1167.538334 1.136693651 0.184843488 0.595194919 1 17.01137558 20.16967021 10311 VPS26 endosomal protein sorting factor C "GO:0003674,GO:0005515,GO:0005634,GO:0005768,GO:0006886,GO:0032456,GO:1990126" "molecular_function|protein binding|nucleus|endosome|intracellular protein transport|endocytic recycling|retrograde transport, endosome to plasma membrane" VPS28 2336.558284 2526.225405 2146.891164 0.84984149 -0.234734315 0.462920423 1 108.2439973 95.95280644 51160 VPS28 subunit of ESCRT-I "GO:0000813,GO:0005515,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0031397,GO:0031902,GO:0036258,GO:0039702,GO:0043130,GO:0043162,GO:0043328,GO:0043657,GO:0044877,GO:0045732,GO:0070062,GO:0075733,GO:2000397" ESCRT I complex|protein binding|cytoplasm|endosome|early endosome|cytosol|plasma membrane|endosome membrane|endosomal transport|macroautophagy|viral life cycle|negative regulation of protein ubiquitination|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|host cell|protein-containing complex binding|positive regulation of protein catabolic process|extracellular exosome|intracellular transport of virus|positive regulation of ubiquitin-dependent endocytosis hsa04144 Endocytosis VPS29 1417.137338 1302.188507 1532.086168 1.176547143 0.234559129 0.48289113 1 36.15748578 44.37347975 51699 VPS29 retromer complex component "GO:0005515,GO:0005768,GO:0005769,GO:0005770,GO:0005829,GO:0006886,GO:0010008,GO:0010506,GO:0016032,GO:0016055,GO:0030904,GO:0030906,GO:0032456,GO:0042147,GO:0043231,GO:0046872,GO:1990126" "protein binding|endosome|early endosome|late endosome|cytosol|intracellular protein transport|endosome membrane|regulation of autophagy|viral process|Wnt signaling pathway|retromer complex|retromer, cargo-selective complex|endocytic recycling|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|metal ion binding|retrograde transport, endosome to plasma membrane" hsa04144 Endocytosis VPS33A 999.7566154 957.1034782 1042.409753 1.089129625 0.12317567 0.728480149 1 8.729320135 9.91689973 65082 VPS33A core subunit of CORVET and HOPS complexes "GO:0005515,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005776,GO:0006886,GO:0006904,GO:0008333,GO:0016192,GO:0030123,GO:0030136,GO:0030220,GO:0030897,GO:0031902,GO:0032400,GO:0032418,GO:0033263,GO:0035751,GO:0048070,GO:0048471,GO:0071439,GO:0097352" protein binding|lysosome|lysosomal membrane|early endosome|late endosome|autophagosome|intracellular protein transport|vesicle docking involved in exocytosis|endosome to lysosome transport|vesicle-mediated transport|AP-3 adaptor complex|clathrin-coated vesicle|platelet formation|HOPS complex|late endosome membrane|melanosome localization|lysosome localization|CORVET complex|regulation of lysosomal lumen pH|regulation of developmental pigmentation|perinuclear region of cytoplasm|clathrin complex|autophagosome maturation hsa05132 Salmonella infection VPS33B 582.5325159 521.6873677 643.377664 1.233262877 0.302480351 0.443137587 1 9.280514497 11.93833172 26276 VPS33B late endosome and lysosome associated "GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005770,GO:0005794,GO:0006886,GO:0006904,GO:0007032,GO:0008333,GO:0015031,GO:0016192,GO:0017185,GO:0030136,GO:0030897,GO:0031091,GO:0031901,GO:0031902,GO:0032400,GO:0032418,GO:0032963,GO:0033263,GO:0044877,GO:0048471,GO:0055037,GO:0061025,GO:0070889,GO:0097352" protein binding|cytoplasm|lysosome|lysosomal membrane|late endosome|Golgi apparatus|intracellular protein transport|vesicle docking involved in exocytosis|endosome organization|endosome to lysosome transport|protein transport|vesicle-mediated transport|peptidyl-lysine hydroxylation|clathrin-coated vesicle|HOPS complex|platelet alpha granule|early endosome membrane|late endosome membrane|melanosome localization|lysosome localization|collagen metabolic process|CORVET complex|protein-containing complex binding|perinuclear region of cytoplasm|recycling endosome|membrane fusion|platelet alpha granule organization|autophagosome maturation VPS35 3319.472617 2971.791075 3667.154158 1.233987876 0.303328221 0.340377592 1 19.78061955 25.46048736 55737 VPS35 retromer complex component "GO:0005515,GO:0005739,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005829,GO:0006886,GO:0010008,GO:0010628,GO:0010821,GO:0016032,GO:0016055,GO:0016241,GO:0030904,GO:0030906,GO:0031647,GO:0031748,GO:0032268,GO:0036010,GO:0042147,GO:0043653,GO:0045056,GO:0050728,GO:0060161,GO:0060548,GO:0070062,GO:0090141,GO:0097422,GO:0099073,GO:0099074,GO:0099639,GO:1901215,GO:1902823,GO:1902950,GO:1903364,GO:1905606,GO:1990126,GO:2000331" "protein binding|mitochondrion|lysosome|lysosomal membrane|endosome|early endosome|late endosome|cytosol|intracellular protein transport|endosome membrane|positive regulation of gene expression|regulation of mitochondrion organization|viral process|Wnt signaling pathway|regulation of macroautophagy|retromer complex|retromer, cargo-selective complex|regulation of protein stability|D1 dopamine receptor binding|regulation of cellular protein metabolic process|protein localization to endosome|retrograde transport, endosome to Golgi|mitochondrial fragmentation involved in apoptotic process|transcytosis|negative regulation of inflammatory response|positive regulation of dopamine receptor signaling pathway|negative regulation of cell death|extracellular exosome|positive regulation of mitochondrial fission|tubular endosome|mitochondrion-derived vesicle|mitochondrion to lysosome transport|neurotransmitter receptor transport, endosome to plasma membrane|negative regulation of neuron death|negative regulation of late endosome to lysosome transport|regulation of dendritic spine maintenance|positive regulation of cellular protein catabolic process|regulation of presynapse assembly|retrograde transport, endosome to plasma membrane|regulation of terminal button organization" hsa04144 Endocytosis VPS35L 901.3192484 963.193214 839.4452829 0.871523253 -0.198388938 0.581682777 1 13.07136612 11.88272065 57020 VPS35 endosomal protein sorting factor like "GO:0005515,GO:0005768,GO:0005886,GO:0006893,GO:0015031,GO:0016021,GO:0032456,GO:0043312,GO:0101003,GO:1990126" "protein binding|endosome|plasma membrane|Golgi to plasma membrane transport|protein transport|integral component of membrane|endocytic recycling|neutrophil degranulation|ficolin-1-rich granule membrane|retrograde transport, endosome to plasma membrane" VPS36 459.3150807 517.6275439 401.0026175 0.774693353 -0.368302734 0.378435721 1 5.531970672 4.470186353 51028 vacuolar protein sorting 36 homolog "GO:0000814,GO:0005515,GO:0005634,GO:0005768,GO:0005829,GO:0008022,GO:0016197,GO:0016236,GO:0031902,GO:0032266,GO:0036258,GO:0043130,GO:0043328,GO:0070062" ESCRT II complex|protein binding|nucleus|endosome|cytosol|protein C-terminus binding|endosomal transport|macroautophagy|late endosome membrane|phosphatidylinositol-3-phosphate binding|multivesicular body assembly|ubiquitin binding|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|extracellular exosome hsa04144 Endocytosis VPS37A 563.5870837 539.9565752 587.2175923 1.087527441 0.121051804 0.763516689 1 2.750366658 3.119943636 137492 VPS37A subunit of ESCRT-I "GO:0000813,GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0006612,GO:0006623,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0036258,GO:0039702,GO:0043162,GO:0043231,GO:0043657,GO:0075733" ESCRT I complex|protein binding|nucleoplasm|centrosome|cytosol|protein targeting to membrane|protein targeting to vacuole|endosome membrane|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|intracellular transport of virus hsa04144 Endocytosis VPS37B 1076.041617 1120.511389 1031.571844 0.920625934 -0.119313011 0.733439819 1 9.214149851 8.8481893 79720 VPS37B subunit of ESCRT-I "GO:0000813,GO:0005515,GO:0005737,GO:0005768,GO:0005886,GO:0006612,GO:0006623,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0030496,GO:0031902,GO:0036258,GO:0039702,GO:0043162,GO:0043231,GO:0043657,GO:0048306,GO:0070062,GO:0075733,GO:1902188,GO:1903774" ESCRT I complex|protein binding|cytoplasm|endosome|plasma membrane|protein targeting to membrane|protein targeting to vacuole|endosome membrane|endosomal transport|macroautophagy|viral life cycle|midbody|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|calcium-dependent protein binding|extracellular exosome|intracellular transport of virus|positive regulation of viral release from host cell|positive regulation of viral budding via host ESCRT complex hsa04144 Endocytosis VPS37C 421.2893666 376.5486643 466.030069 1.237635698 0.307586715 0.473106203 1 6.608060104 8.530662139 55048 VPS37C subunit of ESCRT-I "GO:0000813,GO:0005515,GO:0006612,GO:0006623,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0036258,GO:0039702,GO:0043162,GO:0043231,GO:0043657,GO:0048306,GO:0070062,GO:0075733" ESCRT I complex|protein binding|protein targeting to membrane|protein targeting to vacuole|endosome membrane|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|calcium-dependent protein binding|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis VPS37D 77.8898288 71.04691779 84.73273982 1.192630764 0.254147457 0.741898211 1 1.745888281 2.171892809 155382 VPS37D subunit of ESCRT-I "GO:0000813,GO:0005515,GO:0006612,GO:0006623,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0036258,GO:0039702,GO:0043162,GO:0043231,GO:0043657,GO:0070062,GO:0075733" ESCRT I complex|protein binding|protein targeting to membrane|protein targeting to vacuole|endosome membrane|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis VPS39 1349.590064 1264.635137 1434.54499 1.134354842 0.181872006 0.589322882 1 11.69636748 13.83935543 23339 VPS39 subunit of HOPS complex "GO:0005515,GO:0005737,GO:0005765,GO:0006886,GO:0006914,GO:0008333,GO:0016020,GO:0030123,GO:0030897,GO:0031902,GO:0034058,GO:1902774,GO:1990126" "protein binding|cytoplasm|lysosomal membrane|intracellular protein transport|autophagy|endosome to lysosome transport|membrane|AP-3 adaptor complex|HOPS complex|late endosome membrane|endosomal vesicle fusion|late endosome to lysosome transport|retrograde transport, endosome to plasma membrane" hsa05132 Salmonella infection VPS41 1364.274512 1325.532495 1403.016529 1.058455025 0.081959968 0.808799252 1 11.19265499 12.35723927 27072 VPS41 subunit of HOPS complex "GO:0005515,GO:0005765,GO:0005769,GO:0005770,GO:0005794,GO:0005798,GO:0006623,GO:0008017,GO:0008333,GO:0009267,GO:0010008,GO:0015630,GO:0016236,GO:0030123,GO:0030136,GO:0030897,GO:0031902,GO:0034058,GO:0042802,GO:0043621,GO:0045055,GO:0046872,GO:0071439,GO:1902774" protein binding|lysosomal membrane|early endosome|late endosome|Golgi apparatus|Golgi-associated vesicle|protein targeting to vacuole|microtubule binding|endosome to lysosome transport|cellular response to starvation|endosome membrane|microtubule cytoskeleton|macroautophagy|AP-3 adaptor complex|clathrin-coated vesicle|HOPS complex|late endosome membrane|endosomal vesicle fusion|identical protein binding|protein self-association|regulated exocytosis|metal ion binding|clathrin complex|late endosome to lysosome transport hsa05132 Salmonella infection VPS45 649.8867948 546.046311 753.7272787 1.380335813 0.465019294 0.225986542 1 9.983869789 14.37472662 11311 vacuolar protein sorting 45 homolog "GO:0000139,GO:0003674,GO:0005515,GO:0005575,GO:0005794,GO:0006886,GO:0006904,GO:0007596,GO:0010008,GO:0016021,GO:0016192" Golgi membrane|molecular_function|protein binding|cellular_component|Golgi apparatus|intracellular protein transport|vesicle docking involved in exocytosis|blood coagulation|endosome membrane|integral component of membrane|vesicle-mediated transport hsa04144 Endocytosis VPS4A 1514.637937 1434.132783 1595.14309 1.112270153 0.153507239 0.643843882 1 17.68966541 20.52323564 27183 vacuolar protein sorting 4 homolog A "GO:0000916,GO:0000922,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005774,GO:0005813,GO:0005829,GO:0005886,GO:0006622,GO:0006900,GO:0006997,GO:0006998,GO:0007033,GO:0007080,GO:0008022,GO:0009838,GO:0010008,GO:0016192,GO:0016197,GO:0016236,GO:0016887,GO:0019058,GO:0019076,GO:0019904,GO:0030496,GO:0031468,GO:0031902,GO:0032367,GO:0032466,GO:0032880,GO:0034058,GO:0036258,GO:0039702,GO:0043162,GO:0044877,GO:0044878,GO:0048471,GO:0051301,GO:0061640,GO:0061738,GO:0061952,GO:0070062,GO:0072319,GO:0090543,GO:0090611,GO:1902188,GO:1903076,GO:1903543,GO:1903774,GO:1903902,GO:1904896,GO:1904903" actomyosin contractile ring contraction|spindle pole|protein binding|ATP binding|nucleus|cytoplasm|lysosome|endosome|early endosome|late endosome|vacuolar membrane|centrosome|cytosol|plasma membrane|protein targeting to lysosome|vesicle budding from membrane|nucleus organization|nuclear envelope organization|vacuole organization|mitotic metaphase plate congression|protein C-terminus binding|abscission|endosome membrane|vesicle-mediated transport|endosomal transport|macroautophagy|ATPase activity|viral life cycle|viral release from host cell|protein domain specific binding|midbody|nuclear envelope reassembly|late endosome membrane|intracellular cholesterol transport|negative regulation of cytokinesis|regulation of protein localization|endosomal vesicle fusion|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein-containing complex binding|mitotic cytokinesis checkpoint|perinuclear region of cytoplasm|cell division|cytoskeleton-dependent cytokinesis|late endosomal microautophagy|midbody abscission|extracellular exosome|vesicle uncoating|Flemming body|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|positive regulation of viral release from host cell|regulation of protein localization to plasma membrane|positive regulation of exosomal secretion|positive regulation of viral budding via host ESCRT complex|positive regulation of viral life cycle|ESCRT complex disassembly|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis VPS4B 1632.829089 1566.077059 1699.581119 1.085247439 0.118024019 0.72027481 1 23.39023246 26.47763783 9525 vacuolar protein sorting 4 homolog B "GO:0000922,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005813,GO:0005829,GO:0006813,GO:0006997,GO:0007080,GO:0008022,GO:0008568,GO:0010008,GO:0010824,GO:0010971,GO:0015031,GO:0016197,GO:0016236,GO:0016887,GO:0019058,GO:0019076,GO:0030301,GO:0031122,GO:0031902,GO:0032510,GO:0033993,GO:0036258,GO:0039702,GO:0042802,GO:0042803,GO:0043162,GO:0044877,GO:0048524,GO:0050792,GO:0051013,GO:0051261,GO:0060548,GO:0061738,GO:0061952,GO:0070062,GO:0090543,GO:0090611,GO:1901673,GO:1902188,GO:1903542,GO:1903543,GO:1903724,GO:1903902,GO:1904903" spindle pole|protein binding|ATP binding|nucleus|cytoplasm|endosome|centrosome|cytosol|potassium ion transport|nucleus organization|mitotic metaphase plate congression|protein C-terminus binding|microtubule-severing ATPase activity|endosome membrane|regulation of centrosome duplication|positive regulation of G2/M transition of mitotic cell cycle|protein transport|endosomal transport|macroautophagy|ATPase activity|viral life cycle|viral release from host cell|cholesterol transport|cytoplasmic microtubule organization|late endosome membrane|endosome to lysosome transport via multivesicular body sorting pathway|response to lipid|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein-containing complex binding|positive regulation of viral process|regulation of viral process|microtubule severing|protein depolymerization|negative regulation of cell death|late endosomal microautophagy|midbody abscission|extracellular exosome|Flemming body|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|negative regulation of exosomal secretion|positive regulation of exosomal secretion|positive regulation of centriole elongation|positive regulation of viral life cycle|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis VPS50 538.7206625 490.2237327 587.2175923 1.197856311 0.26045486 0.517525193 1 3.43356419 4.290084299 55610 VPS50 subunit of EARP/GARPII complex "GO:0000149,GO:0005515,GO:0005829,GO:0015031,GO:0016020,GO:0032456,GO:0042147,GO:0055037,GO:0070062,GO:1990745" "SNARE binding|protein binding|cytosol|protein transport|membrane|endocytic recycling|retrograde transport, endosome to Golgi|recycling endosome|extracellular exosome|EARP complex" VPS51 1969.64898 1825.905787 2113.392173 1.157448642 0.21094818 0.513541188 1 34.75223101 41.95660603 738 VPS51 subunit of GARP complex "GO:0000938,GO:0003674,GO:0005515,GO:0005730,GO:0005794,GO:0005829,GO:0006869,GO:0006914,GO:0007030,GO:0007041,GO:0015031,GO:0016020,GO:0016021,GO:0032456,GO:0032588,GO:0042147,GO:0043231,GO:0048193,GO:0048854,GO:0055037,GO:1990745" "GARP complex|molecular_function|protein binding|nucleolus|Golgi apparatus|cytosol|lipid transport|autophagy|Golgi organization|lysosomal transport|protein transport|membrane|integral component of membrane|endocytic recycling|trans-Golgi network membrane|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|Golgi vesicle transport|brain morphogenesis|recycling endosome|EARP complex" VPS52 823.8235746 818.0545105 829.5926387 1.014104351 0.020206113 0.959466768 1 10.86587334 11.49378884 6293 VPS52 subunit of GARP complex "GO:0000938,GO:0005515,GO:0005794,GO:0005829,GO:0006896,GO:0007041,GO:0010008,GO:0010668,GO:0015031,GO:0016020,GO:0019905,GO:0032456,GO:0032588,GO:0042147,GO:0048471,GO:0048611,GO:0055037,GO:1990745" "GARP complex|protein binding|Golgi apparatus|cytosol|Golgi to vacuole transport|lysosomal transport|endosome membrane|ectodermal cell differentiation|protein transport|membrane|syntaxin binding|endocytic recycling|trans-Golgi network membrane|retrograde transport, endosome to Golgi|perinuclear region of cytoplasm|embryonic ectodermal digestive tract development|recycling endosome|EARP complex" VPS53 1094.102983 1142.84042 1045.365546 0.914708237 -0.128616452 0.712539397 1 3.77787583 3.604509705 55275 VPS53 subunit of GARP complex "GO:0000938,GO:0005515,GO:0005794,GO:0005829,GO:0007041,GO:0010008,GO:0015031,GO:0016020,GO:0032456,GO:0032588,GO:0042147,GO:0043231,GO:0048471,GO:0055037,GO:1990745" "GARP complex|protein binding|Golgi apparatus|cytosol|lysosomal transport|endosome membrane|protein transport|membrane|endocytic recycling|trans-Golgi network membrane|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|recycling endosome|EARP complex" VPS54 634.6273205 580.5548139 688.6998272 1.18627873 0.246443027 0.524378225 1 6.839509944 8.46306465 51542 VPS54 subunit of GARP complex "GO:0000938,GO:0005515,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0006896,GO:0007041,GO:0015031,GO:0016020,GO:0019905,GO:0032588,GO:0040008,GO:0042147,GO:0048471,GO:0048873,GO:0050881,GO:0060052" "GARP complex|protein binding|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|Golgi to vacuole transport|lysosomal transport|protein transport|membrane|syntaxin binding|trans-Golgi network membrane|regulation of growth|retrograde transport, endosome to Golgi|perinuclear region of cytoplasm|homeostasis of number of cells within a tissue|musculoskeletal movement|neurofilament cytoskeleton organization" VPS72 955.0391697 863.7275291 1046.35081 1.211436217 0.276718448 0.436509188 1 28.09553777 35.50208276 6944 vacuolar protein sorting 72 homolog "GO:0000122,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0016607,GO:0032991,GO:0035019,GO:0042393,GO:0043486" negative regulation of transcription by RNA polymerase II|DNA binding|protein binding|nucleus|nucleoplasm|nuclear speck|protein-containing complex|somatic stem cell population maintenance|histone binding|histone exchange VPS8 891.388416 823.1292904 959.6475417 1.165852744 0.221385577 0.539273102 1 5.7636658 7.009038083 23355 VPS8 subunit of CORVET complex "GO:0005515,GO:0005769,GO:0015031,GO:0033263,GO:0034058,GO:0046872" protein binding|early endosome|protein transport|CORVET complex|endosomal vesicle fusion|metal ion binding VPS9D1 232.443968 230.3950048 234.4929311 1.017786524 0.025434995 0.969703514 1 3.263057665 3.46415547 9605 VPS9 domain containing 1 "GO:0005096,GO:0005215,GO:0005515,GO:0015986,GO:0042802,GO:0043547" GTPase activator activity|transporter activity|protein binding|ATP synthesis coupled proton transport|identical protein binding|positive regulation of GTPase activity VRK1 586.6935386 570.4052542 602.9818229 1.05711127 0.080127241 0.842203996 1 15.04636138 16.59083031 7443 VRK serine/threonine kinase 1 "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005795,GO:0005819,GO:0005829,GO:0006468,GO:0007077,GO:0007084,GO:0018105,GO:0019901,GO:0031493,GO:0035175,GO:0043987,GO:0046777,GO:0051301,GO:0072354,GO:0072355,GO:0090166,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi stack|spindle|cytosol|protein phosphorylation|mitotic nuclear envelope disassembly|mitotic nuclear envelope reassembly|peptidyl-serine phosphorylation|protein kinase binding|nucleosomal histone binding|histone kinase activity (H3-S10 specific)|histone H3-S10 phosphorylation|protein autophosphorylation|cell division|histone kinase activity (H3-T3 specific)|histone H3-T3 phosphorylation|Golgi disassembly|protein serine kinase activity|protein threonine kinase activity VRK2 481.6225853 459.7750537 503.4701169 1.095035742 0.13097796 0.754411213 1 4.207043266 4.805307706 7444 VRK serine/threonine kinase 2 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005635,GO:0005737,GO:0005783,GO:0005789,GO:0006468,GO:0016021,GO:0016032,GO:0018105,GO:0019901,GO:0019904,GO:0031966,GO:0032991,GO:0034599,GO:0043408,GO:0046777,GO:0106310,GO:0106311,GO:2000659" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|protein phosphorylation|integral component of membrane|viral process|peptidyl-serine phosphorylation|protein kinase binding|protein domain specific binding|mitochondrial membrane|protein-containing complex|cellular response to oxidative stress|regulation of MAPK cascade|protein autophosphorylation|protein serine kinase activity|protein threonine kinase activity|regulation of interleukin-1-mediated signaling pathway VRK3 356.5521497 295.3521868 417.7521126 1.414420246 0.50021083 0.265050135 1 5.683338268 8.384900232 51231 VRK serine/threonine kinase 3 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0018105,GO:0019903,GO:0032516,GO:0043231,GO:0070373" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|peptidyl-serine phosphorylation|protein phosphatase binding|positive regulation of phosphoprotein phosphatase activity|intracellular membrane-bounded organelle|negative regulation of ERK1 and ERK2 cascade VSIG1 120.8473081 145.1387035 96.55591282 0.665266469 -0.587995774 0.357166627 1 2.14245506 1.486699809 340547 V-set and immunoglobulin domain containing 1 "GO:0003382,GO:0005515,GO:0016021,GO:0016323,GO:0030277" epithelial cell morphogenesis|protein binding|integral component of membrane|basolateral plasma membrane|maintenance of gastrointestinal epithelium VSIG10 679.1342038 693.2149264 665.0534812 0.959375593 -0.059832358 0.878548245 1 6.335057832 6.339502527 54621 V-set and immunoglobulin domain containing 10 "GO:0005887,GO:0005911,GO:0050839,GO:0098609" integral component of plasma membrane|cell-cell junction|cell adhesion molecule binding|cell-cell adhesion VSIG10L 65.6361283 41.6131947 89.65906191 2.15458252 1.107408354 0.156771331 1 0.571309707 1.283957549 147645 V-set and immunoglobulin domain containing 10 like "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane VSIG8 5.552566274 9.134603715 1.970528833 0.215721327 -2.212759283 0.247208451 1 0.254474947 0.057260356 391123 V-set and immunoglobulin domain containing 8 "GO:0003723,GO:0005622,GO:0016021" RNA binding|intracellular anatomical structure|integral component of membrane VSIR 420.5740478 361.3243247 479.8237709 1.327958673 0.40921025 0.339155784 1 3.882011534 5.377213879 64115 V-set immunoregulatory receptor "GO:0005515,GO:0005886,GO:0010628,GO:0010950,GO:0016021,GO:0019899,GO:0030335,GO:0031638,GO:0032689,GO:0032693,GO:0032700,GO:0032720,GO:0042802,GO:0045591,GO:0050776,GO:0061133,GO:0120158,GO:2000562,GO:2000565" "protein binding|plasma membrane|positive regulation of gene expression|positive regulation of endopeptidase activity|integral component of membrane|enzyme binding|positive regulation of cell migration|zymogen activation|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of tumor necrosis factor production|identical protein binding|positive regulation of regulatory T cell differentiation|regulation of immune response|endopeptidase activator activity|positive regulation of collagen catabolic process|negative regulation of CD4-positive, alpha-beta T cell proliferation|negative regulation of CD8-positive, alpha-beta T cell proliferation" hsa04514 Cell adhesion molecules VSTM1 76.14198661 86.27125731 66.01271591 0.765176236 -0.386136027 0.610603696 1 2.867017609 2.288272617 284415 V-set and transmembrane domain containing 1 "GO:0002376,GO:0005125,GO:0005615,GO:0007165,GO:0016021" immune system process|cytokine activity|extracellular space|signal transduction|integral component of membrane VSTM5 2.463161041 0 4.926322083 Inf Inf 0.189235799 1 0 0.08515979 387804 V-set and transmembrane domain containing 5 "GO:0005886,GO:0016021,GO:0021517,GO:0030424,GO:0030425,GO:0046847,GO:0051260,GO:1904891" plasma membrane|integral component of membrane|ventral spinal cord development|axon|dendrite|filopodium assembly|protein homooligomerization|positive regulation of excitatory synapse assembly VTA1 763.7791067 855.6078813 671.9503321 0.78534846 -0.348595173 0.34749126 1 6.198472434 5.077652789 51534 vesicle trafficking 1 "GO:0005515,GO:0005654,GO:0005771,GO:0005829,GO:0008022,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0032511,GO:0036258,GO:0043231,GO:0046755,GO:0070062,GO:0071985,GO:1904903" protein binding|nucleoplasm|multivesicular body|cytosol|protein C-terminus binding|endosome membrane|protein transport|endosomal transport|macroautophagy|viral life cycle|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|intracellular membrane-bounded organelle|viral budding|extracellular exosome|multivesicular body sorting pathway|ESCRT III complex disassembly hsa04144 Endocytosis VTI1A 453.3765243 482.104085 424.6489635 0.880824239 -0.183073925 0.665028848 1 3.335638134 3.064672822 143187 vesicle transport through interaction with t-SNAREs 1A "GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005768,GO:0005776,GO:0005789,GO:0005794,GO:0005829,GO:0006623,GO:0006888,GO:0006891,GO:0006896,GO:0006914,GO:0008021,GO:0012507,GO:0016021,GO:0030136,GO:0031201,GO:0031902,GO:0032588,GO:0042147,GO:0043025,GO:0043231,GO:0044306,GO:0048280,GO:0048471,GO:0050882,GO:0090161" "Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|endosome|autophagosome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to vacuole|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi to vacuole transport|autophagy|synaptic vesicle|ER to Golgi transport vesicle membrane|integral component of membrane|clathrin-coated vesicle|SNARE complex|late endosome membrane|trans-Golgi network membrane|retrograde transport, endosome to Golgi|neuronal cell body|intracellular membrane-bounded organelle|neuron projection terminus|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|voluntary musculoskeletal movement|Golgi ribbon formation" hsa04130 SNARE interactions in vesicular transport VTI1B 2092.508633 2007.582905 2177.434361 1.084604952 0.117169662 0.716192779 1 19.77382183 22.37062559 10490 vesicle transport through interaction with t-SNAREs 1B "GO:0000149,GO:0002576,GO:0005484,GO:0005515,GO:0005576,GO:0005765,GO:0005789,GO:0005794,GO:0005829,GO:0006623,GO:0006888,GO:0006891,GO:0006896,GO:0006904,GO:0008021,GO:0012507,GO:0016021,GO:0016192,GO:0019869,GO:0031093,GO:0031201,GO:0031901,GO:0031902,GO:0031982,GO:0042147,GO:0043025,GO:0043231,GO:0048280,GO:0048471,GO:0055037,GO:0055038,GO:0061025,GO:0097352,GO:1903076" "SNARE binding|platelet degranulation|SNAP receptor activity|protein binding|extracellular region|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to vacuole|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi to vacuole transport|vesicle docking involved in exocytosis|synaptic vesicle|ER to Golgi transport vesicle membrane|integral component of membrane|vesicle-mediated transport|chloride channel inhibitor activity|platelet alpha granule lumen|SNARE complex|early endosome membrane|late endosome membrane|vesicle|retrograde transport, endosome to Golgi|neuronal cell body|intracellular membrane-bounded organelle|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|membrane fusion|autophagosome maturation|regulation of protein localization to plasma membrane" hsa04130 SNARE interactions in vesicular transport VTN 4.478227202 3.044867905 5.911586499 1.941491941 0.957165719 0.701636232 1 0.094841216 0.19206518 7448 vitronectin "GO:0005044,GO:0005178,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0006897,GO:0006955,GO:0007155,GO:0007160,GO:0008201,GO:0010951,GO:0014911,GO:0016477,GO:0030195,GO:0030198,GO:0030247,GO:0030449,GO:0030949,GO:0032092,GO:0033627,GO:0035987,GO:0043231,GO:0048260,GO:0050731,GO:0061302,GO:0062023,GO:0070062,GO:0071062,GO:0072562,GO:0090303" scavenger receptor activity|integrin binding|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|endoplasmic reticulum|endocytosis|immune response|cell adhesion|cell-matrix adhesion|heparin binding|negative regulation of endopeptidase activity|positive regulation of smooth muscle cell migration|cell migration|negative regulation of blood coagulation|extracellular matrix organization|polysaccharide binding|regulation of complement activation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of protein binding|cell adhesion mediated by integrin|endodermal cell differentiation|intracellular membrane-bounded organelle|positive regulation of receptor-mediated endocytosis|positive regulation of peptidyl-tyrosine phosphorylation|smooth muscle cell-matrix adhesion|collagen-containing extracellular matrix|extracellular exosome|alphav-beta3 integrin-vitronectin complex|blood microparticle|positive regulation of wound healing "hsa04151,hsa04510,hsa04512,hsa04610,hsa05165,hsa05205" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Complement and coagulation cascades|Human papillomavirus infection|Proteoglycans in cancer VWA1 148.3577613 173.5574706 123.1580521 0.709609628 -0.494902511 0.407109623 1 1.956828498 1.448398923 64856 von Willebrand factor A domain containing 1 "GO:0005201,GO:0005604,GO:0005614,GO:0005615,GO:0005788,GO:0030198,GO:0042802,GO:0043687,GO:0044267,GO:0048266,GO:0062023,GO:0070062" extracellular matrix structural constituent|basement membrane|interstitial matrix|extracellular space|endoplasmic reticulum lumen|extracellular matrix organization|identical protein binding|post-translational protein modification|cellular protein metabolic process|behavioral response to pain|collagen-containing extracellular matrix|extracellular exosome VWA5B2 12.07555119 17.25425146 6.896850916 0.399718929 -1.3229422 0.32338084 1 0.183778542 0.076624111 90113 von Willebrand factor A domain containing 5B2 VWA7 12.9420494 9.134603715 16.74949508 1.833631278 0.874703559 0.515481793 1 0.105866236 0.202481529 80737 von Willebrand factor A domain containing 7 "GO:0003674,GO:0005575,GO:0005576,GO:0008150" molecular_function|cellular_component|extracellular region|biological_process VWA8 547.8443798 642.467128 453.2216316 0.70543941 -0.50340592 0.207786104 1 4.380545711 3.223323278 23078 von Willebrand factor A domain containing 8 "GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005777,GO:0016887" protein binding|ATP binding|cytoplasm|mitochondrion|peroxisome|ATPase activity VWCE 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.042896194 0 220001 von Willebrand factor C and EGF domains "GO:0003674,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0098586" molecular_function|calcium ion binding|protein binding|extracellular region|cytoplasm|cellular response to virus VWDE 117.0425841 120.7797602 113.3054079 0.938115854 -0.092161994 0.899006509 1 0.750560585 0.734443108 221806 von Willebrand factor D and EGF domains "GO:0005102,GO:0005576,GO:0009986,GO:0048856" signaling receptor binding|extracellular region|cell surface|anatomical structure development WAC 3614.378193 3363.564079 3865.192306 1.149135921 0.200549452 0.528727596 1 42.21874961 50.60491468 51322 WW domain containing adaptor with coiled-coil "GO:0000993,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006974,GO:0010390,GO:0016239,GO:0016567,GO:0016607,GO:0032435,GO:0044783,GO:0045893,GO:0071894" "RNA polymerase II complex binding|chromatin binding|protein binding|nucleus|nucleoplasm|cellular response to DNA damage stimulus|histone monoubiquitination|positive regulation of macroautophagy|protein ubiquitination|nuclear speck|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|G1 DNA damage checkpoint|positive regulation of transcription, DNA-templated|histone H2B conserved C-terminal lysine ubiquitination" WAPL 3091.367575 3172.752357 3009.982793 0.948697678 -0.07597968 0.811948501 1 20.16675629 19.95629049 23063 WAPL cohesin release factor "GO:0000278,GO:0000775,GO:0000785,GO:0000795,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0008156,GO:0009636,GO:0016032,GO:0035562,GO:0045132,GO:0045171,GO:0045875,GO:0048146,GO:0051301,GO:0051983,GO:0060623,GO:0071168,GO:0071922,GO:0072686" "mitotic cell cycle|chromosome, centromeric region|chromatin|synaptonemal complex|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|Golgi apparatus|centrosome|cytosol|negative regulation of DNA replication|response to toxic substance|viral process|negative regulation of chromatin binding|meiotic chromosome segregation|intercellular bridge|negative regulation of sister chromatid cohesion|positive regulation of fibroblast proliferation|cell division|regulation of chromosome segregation|regulation of chromosome condensation|protein localization to chromatin|regulation of cohesin loading|mitotic spindle" WARS1 2779.51555 2632.795782 2926.235317 1.111455487 0.15245017 0.632522936 1 45.4626043 52.70627385 7453 tryptophanyl-tRNA synthetase 1 "GO:0001525,GO:0001933,GO:0004830,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006436,GO:0006469,GO:0008285,GO:0010628,GO:0010835,GO:0019210,GO:0019901,GO:0019904,GO:0031334,GO:0032991,GO:0042803,GO:0045765,GO:0070062" angiogenesis|negative regulation of protein phosphorylation|tryptophan-tRNA ligase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|tryptophanyl-tRNA aminoacylation|negative regulation of protein kinase activity|negative regulation of cell population proliferation|positive regulation of gene expression|regulation of protein ADP-ribosylation|kinase inhibitor activity|protein kinase binding|protein domain specific binding|positive regulation of protein-containing complex assembly|protein-containing complex|protein homodimerization activity|regulation of angiogenesis|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis WARS2 314.9780491 282.1577592 347.798339 1.232637869 0.301749019 0.519192744 1 4.374133796 5.623976519 10352 "tryptophanyl tRNA synthetase 2, mitochondrial" "GO:0001570,GO:0004830,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0005886,GO:0006418,GO:0006436,GO:0070183" vasculogenesis|tryptophan-tRNA ligase activity|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|plasma membrane|tRNA aminoacylation for protein translation|tryptophanyl-tRNA aminoacylation|mitochondrial tryptophanyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis WAS 14.55355801 18.26920743 10.83790858 0.593233649 -0.753327664 0.562628766 1 0.390409665 0.241580718 7454 WASP actin nucleation promoting factor "GO:0002625,GO:0003779,GO:0005515,GO:0005634,GO:0005829,GO:0005884,GO:0005886,GO:0005911,GO:0006952,GO:0006955,GO:0007266,GO:0007596,GO:0008064,GO:0008154,GO:0008544,GO:0010591,GO:0012506,GO:0015629,GO:0016197,GO:0017124,GO:0019901,GO:0030041,GO:0030048,GO:0030695,GO:0031267,GO:0032488,GO:0035861,GO:0038096,GO:0042110,GO:0042802,GO:0043274,GO:0045335,GO:0045944,GO:0050790,GO:0050852,GO:0051492,GO:0051497,GO:0065003,GO:0070062,GO:0071346,GO:1905168,GO:2000146,GO:2000601,GO:2001032" regulation of T cell antigen processing and presentation|actin binding|protein binding|nucleus|cytosol|actin filament|plasma membrane|cell-cell junction|defense response|immune response|Rho protein signal transduction|blood coagulation|regulation of actin polymerization or depolymerization|actin polymerization or depolymerization|epidermis development|regulation of lamellipodium assembly|vesicle membrane|actin cytoskeleton|endosomal transport|SH3 domain binding|protein kinase binding|actin filament polymerization|actin filament-based movement|GTPase regulator activity|small GTPase binding|Cdc42 protein signal transduction|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|T cell activation|identical protein binding|phospholipase binding|phagocytic vesicle|positive regulation of transcription by RNA polymerase II|regulation of catalytic activity|T cell receptor signaling pathway|regulation of stress fiber assembly|negative regulation of stress fiber assembly|protein-containing complex assembly|extracellular exosome|cellular response to interferon-gamma|positive regulation of double-strand break repair via homologous recombination|negative regulation of cell motility|positive regulation of Arp2/3 complex-mediated actin nucleation|regulation of double-strand break repair via nonhomologous end joining "hsa04062,hsa04520,hsa04530,hsa04666,hsa05135,hsa05231" Chemokine signaling pathway|Adherens junction|Tight junction|Fc gamma R-mediated phagocytosis|Yersinia infection|Choline metabolism in cancer WASF1 545.6120702 557.2108266 534.0133138 0.958368517 -0.061347579 0.88238123 1 9.778504036 9.775092768 8936 WASP family member 1 "GO:0003779,GO:0005515,GO:0005741,GO:0005856,GO:0005925,GO:0006898,GO:0015629,GO:0016601,GO:0030027,GO:0030036,GO:0030041,GO:0031209,GO:0031267,GO:0032839,GO:0032991,GO:0034237,GO:0051018,GO:0051388,GO:0065003,GO:0070584,GO:0071933,GO:0072673,GO:0097484,GO:0098794,GO:0098885,GO:0098939,GO:1990416,GO:2000601" actin binding|protein binding|mitochondrial outer membrane|cytoskeleton|focal adhesion|receptor-mediated endocytosis|actin cytoskeleton|Rac protein signal transduction|lamellipodium|actin cytoskeleton organization|actin filament polymerization|SCAR complex|small GTPase binding|dendrite cytoplasm|protein-containing complex|protein kinase A regulatory subunit binding|protein kinase A binding|positive regulation of neurotrophin TRK receptor signaling pathway|protein-containing complex assembly|mitochondrion morphogenesis|Arp2/3 complex binding|lamellipodium morphogenesis|dendrite extension|postsynapse|modification of postsynaptic actin cytoskeleton|dendritic transport of mitochondrion|cellular response to brain-derived neurotrophic factor stimulus|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04520,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05231" Adherens junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Choline metabolism in cancer WASF2 2809.743026 2476.492563 3142.993489 1.269131002 0.343840995 0.280308183 1 22.07808692 29.22697188 10163 WASP family member 2 "GO:0001525,GO:0001667,GO:0001726,GO:0003779,GO:0005515,GO:0005769,GO:0005829,GO:0005911,GO:0006897,GO:0007188,GO:0010592,GO:0015629,GO:0016032,GO:0016323,GO:0016601,GO:0017124,GO:0030027,GO:0030032,GO:0030036,GO:0030048,GO:0031209,GO:0032991,GO:0034237,GO:0035855,GO:0038096,GO:0045202,GO:0045296,GO:0048010,GO:0051018,GO:0051497,GO:0070062,GO:0071933,GO:0072673,GO:0098974,GO:2000601" angiogenesis|ameboidal-type cell migration|ruffle|actin binding|protein binding|early endosome|cytosol|cell-cell junction|endocytosis|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|positive regulation of lamellipodium assembly|actin cytoskeleton|viral process|basolateral plasma membrane|Rac protein signal transduction|SH3 domain binding|lamellipodium|lamellipodium assembly|actin cytoskeleton organization|actin filament-based movement|SCAR complex|protein-containing complex|protein kinase A regulatory subunit binding|megakaryocyte development|Fc-gamma receptor signaling pathway involved in phagocytosis|synapse|cadherin binding|vascular endothelial growth factor receptor signaling pathway|protein kinase A binding|negative regulation of stress fiber assembly|extracellular exosome|Arp2/3 complex binding|lamellipodium morphogenesis|postsynaptic actin cytoskeleton organization|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04520,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05135,hsa05231" Adherens junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Yersinia infection|Choline metabolism in cancer WASF3 287.6281779 298.3970547 276.859301 0.927821829 -0.108080306 0.82768789 1 2.789875972 2.700010246 10810 WASP family member 3 "GO:0003779,GO:0005856,GO:0007010,GO:0008360,GO:0014003,GO:0030027,GO:0030032,GO:0030036,GO:0030041,GO:0031209,GO:0031643,GO:0034237,GO:0065003,GO:0070062,GO:0071933,GO:0098794,GO:0098885,GO:0098978,GO:2000601" actin binding|cytoskeleton|cytoskeleton organization|regulation of cell shape|oligodendrocyte development|lamellipodium|lamellipodium assembly|actin cytoskeleton organization|actin filament polymerization|SCAR complex|positive regulation of myelination|protein kinase A regulatory subunit binding|protein-containing complex assembly|extracellular exosome|Arp2/3 complex binding|postsynapse|modification of postsynaptic actin cytoskeleton|glutamatergic synapse|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04520,hsa04666,hsa05130,hsa05132,hsa05231" Adherens junction|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Salmonella infection|Choline metabolism in cancer WASHC1 159.6316406 136.0040998 183.2591815 1.347453362 0.430235339 0.461108303 1 1.24784925 1.753847364 100287171 WASH complex subunit 1 "GO:0000145,GO:0003779,GO:0005515,GO:0005769,GO:0005770,GO:0005776,GO:0005814,GO:0005829,GO:0006887,GO:0010507,GO:0015031,GO:0016197,GO:0022617,GO:0030335,GO:0031274,GO:0031396,GO:0031625,GO:0031901,GO:0034314,GO:0042147,GO:0043014,GO:0043231,GO:0043553,GO:0055037,GO:0055038,GO:0071203,GO:1990126" "exocyst|actin binding|protein binding|early endosome|late endosome|autophagosome|centriole|cytosol|exocytosis|negative regulation of autophagy|protein transport|endosomal transport|extracellular matrix disassembly|positive regulation of cell migration|positive regulation of pseudopodium assembly|regulation of protein ubiquitination|ubiquitin protein ligase binding|early endosome membrane|Arp2/3 complex-mediated actin nucleation|retrograde transport, endosome to Golgi|alpha-tubulin binding|intracellular membrane-bounded organelle|negative regulation of phosphatidylinositol 3-kinase activity|recycling endosome|recycling endosome membrane|WASH complex|retrograde transport, endosome to plasma membrane" hsa04144 Endocytosis WASHC2A 1126.761207 1018.000836 1235.521578 1.213674424 0.279381461 0.419035703 1 10.51777868 13.31503025 387680 WASH complex subunit 2A "GO:0005515,GO:0005730,GO:0005769,GO:0005829,GO:0005886,GO:0008289,GO:0015031,GO:0031901,GO:0036010,GO:0042147,GO:0043231,GO:0071203" "protein binding|nucleolus|early endosome|cytosol|plasma membrane|lipid binding|protein transport|early endosome membrane|protein localization to endosome|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|WASH complex" hsa04144 Endocytosis WASHC2C 1349.447049 1187.498483 1511.395615 1.272755828 0.347955672 0.300826024 1 11.54590304 15.32812135 253725 WASH complex subunit 2C "GO:0005515,GO:0005546,GO:0005547,GO:0005730,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0010314,GO:0015031,GO:0031901,GO:0032266,GO:0036010,GO:0042147,GO:0043231,GO:0043325,GO:0070273,GO:0071203,GO:0080025,GO:1900024,GO:1905394,GO:1990126,GO:2000813" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleolus|endosome|early endosome|cytosol|plasma membrane|phosphatidylinositol-5-phosphate binding|protein transport|early endosome membrane|phosphatidylinositol-3-phosphate binding|protein localization to endosome|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4-phosphate binding|WASH complex|phosphatidylinositol-3,5-bisphosphate binding|regulation of substrate adhesion-dependent cell spreading|retromer complex binding|retrograde transport, endosome to plasma membrane|negative regulation of barbed-end actin filament capping" hsa04144 Endocytosis WASHC3 461.7661176 483.1190409 440.4131942 0.911603884 -0.133521023 0.752466734 1 23.80182401 22.63248996 51019 WASH complex subunit 3 "GO:0005515,GO:0005769,GO:0006887,GO:0008150,GO:0015031,GO:0030041,GO:0071203" protein binding|early endosome|exocytosis|biological_process|protein transport|actin filament polymerization|WASH complex hsa04144 Endocytosis WASHC4 1841.427035 1681.78204 2001.07203 1.189852182 0.250782356 0.439676372 1 13.59124419 16.86817728 23325 WASH complex subunit 4 "GO:0005654,GO:0005768,GO:0005769,GO:0007032,GO:0015031,GO:0016197,GO:0031083,GO:0071203" nucleoplasm|endosome|early endosome|endosome organization|protein transport|endosomal transport|BLOC-1 complex|WASH complex hsa04144 Endocytosis WASHC5 3537.808154 3584.82448 3490.791828 0.973769245 -0.038348159 0.904886884 1 33.49791761 34.02434659 9897 WASH complex subunit 5 "GO:0001556,GO:0005515,GO:0005654,GO:0005768,GO:0005769,GO:0005783,GO:0005829,GO:0007032,GO:0007040,GO:0010976,GO:0015031,GO:0016197,GO:0030041,GO:0034629,GO:0040038,GO:0043005,GO:0043025,GO:0051125,GO:0071203,GO:0090306,GO:0097494,GO:0140285" oocyte maturation|protein binding|nucleoplasm|endosome|early endosome|endoplasmic reticulum|cytosol|endosome organization|lysosome organization|positive regulation of neuron projection development|protein transport|endosomal transport|actin filament polymerization|cellular protein-containing complex localization|polar body extrusion after meiotic divisions|neuron projection|neuronal cell body|regulation of actin nucleation|WASH complex|spindle assembly involved in meiosis|regulation of vesicle size|endosome fission hsa04144 Endocytosis WASL 1204.372926 1204.752734 1203.993117 0.999369483 -0.000909931 1 1 13.98498187 14.57820056 8976 WASP like actin nucleation promoting factor "GO:0003779,GO:0005515,GO:0005634,GO:0005829,GO:0005884,GO:0005886,GO:0006900,GO:0008154,GO:0009617,GO:0015629,GO:0016050,GO:0030027,GO:0030041,GO:0030048,GO:0030050,GO:0030478,GO:0030666,GO:0030695,GO:0031410,GO:0032880,GO:0034629,GO:0038096,GO:0045944,GO:0048013,GO:0050999,GO:0051301,GO:0051491,GO:0051653,GO:0060997,GO:0061024,GO:0065003,GO:0070062,GO:1903526,GO:2000370,GO:2000402,GO:2000601" actin binding|protein binding|nucleus|cytosol|actin filament|plasma membrane|vesicle budding from membrane|actin polymerization or depolymerization|response to bacterium|actin cytoskeleton|vesicle organization|lamellipodium|actin filament polymerization|actin filament-based movement|vesicle transport along actin filament|actin cap|endocytic vesicle membrane|GTPase regulator activity|cytoplasmic vesicle|regulation of protein localization|cellular protein-containing complex localization|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of transcription by RNA polymerase II|ephrin receptor signaling pathway|regulation of nitric-oxide synthase activity|cell division|positive regulation of filopodium assembly|spindle localization|dendritic spine morphogenesis|membrane organization|protein-containing complex assembly|extracellular exosome|negative regulation of membrane tubulation|positive regulation of clathrin-dependent endocytosis|negative regulation of lymphocyte migration|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04144,hsa04520,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Adherens junction|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection WBP1 825.3757001 823.1292904 827.6221099 1.005458219 0.007853132 0.986582382 1 35.47965509 37.20997235 23559 WW domain binding protein 1 "GO:0005515,GO:0005575,GO:0008150,GO:0050699" protein binding|cellular_component|biological_process|WW domain binding WBP11 2657.036444 2544.494613 2769.578275 1.088459084 0.122287176 0.701753473 1 28.13134156 31.93879168 51729 WW domain binding protein 11 "GO:0000398,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0006364,GO:0043231,GO:0045292,GO:0050699" "mRNA splicing, via spliceosome|single-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytosol|rRNA processing|intracellular membrane-bounded organelle|mRNA cis splicing, via spliceosome|WW domain binding" hsa03040 Spliceosome WBP1L 2465.788751 2200.424539 2731.152963 1.241193649 0.31172822 0.328841576 1 18.85680885 24.41314176 54838 WW domain binding protein 1 like "GO:0005515,GO:0016021" protein binding|integral component of membrane WBP2 2252.755877 1916.236868 2589.274887 1.351229031 0.43427223 0.175149962 1 47.71417763 67.25000798 23558 WW domain binding protein 2 "GO:0000785,GO:0000978,GO:0003713,GO:0005515,GO:0005634,GO:0005737,GO:0030331,GO:0031490,GO:0032570,GO:0033148,GO:0043627,GO:0045184,GO:0045815,GO:0045893,GO:0045944,GO:0050847,GO:0071391,GO:0071442" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription coactivator activity|protein binding|nucleus|cytoplasm|estrogen receptor binding|chromatin DNA binding|response to progesterone|positive regulation of intracellular estrogen receptor signaling pathway|response to estrogen|establishment of protein localization|positive regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|progesterone receptor signaling pathway|cellular response to estrogen stimulus|positive regulation of histone H3-K14 acetylation" WBP4 274.0032228 242.5744764 305.4319691 1.259126573 0.332423316 0.496736458 1 4.875214873 6.402934821 11193 WW domain binding protein 4 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0008270,GO:0008380,GO:0016607,GO:0045292,GO:0070064,GO:0071005,GO:0071011" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|zinc ion binding|RNA splicing|nuclear speck|mRNA cis splicing, via spliceosome|proline-rich region binding|U2-type precatalytic spliceosome|precatalytic spliceosome" WDCP 357.8167623 348.1298972 367.5036274 1.055650866 0.078132773 0.867265662 1 4.52207006 4.97935998 80304 WD repeat and coiled coil containing "GO:0019900,GO:0051259" kinase binding|protein complex oligomerization WDFY1 1790.711403 1919.281736 1662.141071 0.86602245 -0.207523671 0.52376488 1 21.09938118 19.0596446 57590 WD repeat and FYVE domain containing 1 "GO:0005515,GO:0005545,GO:0005634,GO:0005769,GO:0005829,GO:0008270,GO:0034141,GO:0034145" protein binding|1-phosphatidylinositol binding|nucleus|early endosome|cytosol|zinc ion binding|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway WDFY2 793.2912641 684.0803227 902.5022056 1.319292743 0.399764726 0.277523251 1 2.363802624 3.252882033 115825 WD repeat and FYVE domain containing 2 "GO:0001934,GO:0005515,GO:0005769,GO:0031982,GO:0043231,GO:0045600,GO:0046872" positive regulation of protein phosphorylation|protein binding|early endosome|vesicle|intracellular membrane-bounded organelle|positive regulation of fat cell differentiation|metal ion binding WDFY3 1735.724394 1629.004329 1842.444459 1.1310249 0.177630692 0.586619969 1 5.623565026 6.634371967 23001 WD repeat and FYVE domain containing 3 "GO:0005515,GO:0005545,GO:0005635,GO:0005654,GO:0005730,GO:0005737,GO:0005776,GO:0005829,GO:0005886,GO:0007275,GO:0016234,GO:0016605,GO:0019898,GO:0030424,GO:0031965,GO:0034274,GO:0035973,GO:0043204,GO:0046872,GO:0097635" protein binding|1-phosphatidylinositol binding|nuclear envelope|nucleoplasm|nucleolus|cytoplasm|autophagosome|cytosol|plasma membrane|multicellular organism development|inclusion body|PML body|extrinsic component of membrane|axon|nuclear membrane|Atg12-Atg5-Atg16 complex|aggrephagy|perikaryon|metal ion binding|extrinsic component of autophagosome membrane WDHD1 782.3736835 745.9926368 818.7547302 1.097537281 0.134269946 0.718126796 1 6.277105059 7.186122369 11169 WD repeat and HMG-box DNA binding protein 1 "GO:0000278,GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0005737,GO:0006261,GO:0006281,GO:0043596" mitotic cell cycle|DNA binding|chromatin binding|protein binding|nucleoplasm|cytoplasm|DNA-dependent DNA replication|DNA repair|nuclear replication fork HMG WDPCP 62.14044392 72.06187375 52.21901408 0.724641358 -0.464660946 0.565126605 1 0.233833911 0.176744758 51057 WD repeat containing planar cell polarity effector "GO:0001822,GO:0002093,GO:0005886,GO:0005930,GO:0005938,GO:0007224,GO:0007399,GO:0010762,GO:0016324,GO:0016476,GO:0032185,GO:0032880,GO:0042733,GO:0043010,GO:0043587,GO:0044782,GO:0045184,GO:0051893,GO:0055123,GO:0060021,GO:0060271,GO:0060541,GO:0072359,GO:0090521,GO:0097541,GO:1900027,GO:2000114" kidney development|auditory receptor cell morphogenesis|plasma membrane|axoneme|cell cortex|smoothened signaling pathway|nervous system development|regulation of fibroblast migration|apical plasma membrane|regulation of embryonic cell shape|septin cytoskeleton organization|regulation of protein localization|embryonic digit morphogenesis|camera-type eye development|tongue morphogenesis|cilium organization|establishment of protein localization|regulation of focal adhesion assembly|digestive system development|roof of mouth development|cilium assembly|respiratory system development|circulatory system development|glomerular visceral epithelial cell migration|axonemal basal plate|regulation of ruffle assembly|regulation of establishment of cell polarity WDR1 6561.577237 6615.483002 6507.671471 0.983703151 -0.023705072 0.94252245 1 111.9448299 114.8640257 9948 WD repeat domain 1 "GO:0002102,GO:0002446,GO:0002576,GO:0005576,GO:0005829,GO:0005886,GO:0005911,GO:0007605,GO:0008360,GO:0030042,GO:0030043,GO:0030054,GO:0030220,GO:0030834,GO:0030836,GO:0030864,GO:0030865,GO:0040011,GO:0042247,GO:0042995,GO:0043297,GO:0045199,GO:0045214,GO:0048713,GO:0051015,GO:0060307,GO:0070062,GO:1990266" podosome|neutrophil mediated immunity|platelet degranulation|extracellular region|cytosol|plasma membrane|cell-cell junction|sensory perception of sound|regulation of cell shape|actin filament depolymerization|actin filament fragmentation|cell junction|platelet formation|regulation of actin filament depolymerization|positive regulation of actin filament depolymerization|cortical actin cytoskeleton|cortical cytoskeleton organization|locomotion|establishment of planar polarity of follicular epithelium|cell projection|apical junction assembly|maintenance of epithelial cell apical/basal polarity|sarcomere organization|regulation of oligodendrocyte differentiation|actin filament binding|regulation of ventricular cardiac muscle cell membrane repolarization|extracellular exosome|neutrophil migration WDR11 1424.791323 1353.951262 1495.631384 1.104641966 0.143578843 0.668072316 1 14.77863253 17.0283167 55717 WD repeat domain 11 "GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005802,GO:0005829,GO:0005930,GO:0006886,GO:0007507,GO:0008589,GO:0015630,GO:0016020,GO:0031410,GO:0035264,GO:0036064,GO:0060271,GO:0060322,GO:0099041" protein binding|nucleus|cytoplasm|lysosomal membrane|trans-Golgi network|cytosol|axoneme|intracellular protein transport|heart development|regulation of smoothened signaling pathway|microtubule cytoskeleton|membrane|cytoplasmic vesicle|multicellular organism growth|ciliary basal body|cilium assembly|head development|vesicle tethering to Golgi WDR12 687.1026722 732.7982092 641.4071352 0.875284802 -0.192175575 0.613996927 1 4.600104628 4.199842721 55759 WD repeat domain 12 "GO:0000463,GO:0000466,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0007219,GO:0030687,GO:0042273,GO:0043021,GO:0051726,GO:0070545" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|protein binding|nucleoplasm|nucleolus|rRNA processing|Notch signaling pathway|preribosome, large subunit precursor|ribosomal large subunit biogenesis|ribonucleoprotein complex binding|regulation of cell cycle|PeBoW complex" WDR13 1368.499123 1142.84042 1594.157826 1.394908508 0.480170499 0.152694183 1 28.17956942 41.00114697 64743 WD repeat domain 13 "GO:0005654,GO:0005886,GO:0034451,GO:1904691,GO:1990841" nucleoplasm|plasma membrane|centriolar satellite|negative regulation of type B pancreatic cell proliferation|promoter-specific chromatin binding WDR18 737.2687637 828.2040702 646.3334573 0.780403623 -0.357707619 0.338559833 1 21.42268357 17.43849816 57418 WD repeat domain 18 "GO:0005515,GO:0005654,GO:0005656,GO:0005730,GO:0005737,GO:0006364,GO:0007275,GO:0030174,GO:0097344" protein binding|nucleoplasm|nuclear pre-replicative complex|nucleolus|cytoplasm|rRNA processing|multicellular organism development|regulation of DNA-dependent DNA replication initiation|Rix1 complex WDR19 815.2343053 702.3495301 928.1190804 1.321448995 0.402120741 0.272083657 1 7.991805428 11.0156781 57728 WD repeat domain 19 "GO:0000902,GO:0001701,GO:0001750,GO:0005515,GO:0005737,GO:0005856,GO:0005929,GO:0008406,GO:0030326,GO:0030991,GO:0031076,GO:0031514,GO:0032391,GO:0035721,GO:0035735,GO:0042471,GO:0048701,GO:0050877,GO:0055123,GO:0060271,GO:0060830,GO:0060831,GO:0061055,GO:0065003,GO:0097542,GO:0097730,GO:1903441" cell morphogenesis|in utero embryonic development|photoreceptor outer segment|protein binding|cytoplasm|cytoskeleton|cilium|gonad development|embryonic limb morphogenesis|intraciliary transport particle A|embryonic camera-type eye development|motile cilium|photoreceptor connecting cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ear morphogenesis|embryonic cranial skeleton morphogenesis|nervous system process|digestive system development|cilium assembly|ciliary receptor clustering involved in smoothened signaling pathway|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|myotome development|protein-containing complex assembly|ciliary tip|non-motile cilium|protein localization to ciliary membrane WDR20 501.5505602 474.9993932 528.1017273 1.11179453 0.15289019 0.711118848 1 2.738111037 3.175349391 91833 WD repeat domain 20 "GO:0005515,GO:0005654,GO:0016579" protein binding|nucleoplasm|protein deubiquitination WDR24 392.1646833 372.4888404 411.8405261 1.105645274 0.144888598 0.743757194 1 5.374713876 6.19850696 84219 WD repeat domain 24 "GO:0005515,GO:0005765,GO:0005829,GO:0006914,GO:0010506,GO:0032008,GO:0034198,GO:0043231,GO:0061700" protein binding|lysosomal membrane|cytosol|autophagy|regulation of autophagy|positive regulation of TOR signaling|cellular response to amino acid starvation|intracellular membrane-bounded organelle|GATOR2 complex hsa04150 mTOR signaling pathway WDR25 160.7950543 148.1835714 173.4065373 1.170214321 0.226772779 0.701943205 1 3.758124752 4.587251283 79446 WD repeat domain 25 GO:0005515 protein binding WDR26 3263.969719 3151.438282 3376.501156 1.071415923 0.099518642 0.754929149 1 21.66543116 24.21259638 80232 WD repeat domain 26 "GO:0000151,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829" ubiquitin ligase complex|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol WDR27 407.1839035 355.2345889 459.1332181 1.292478921 0.370140752 0.39184461 1 0.933017618 1.257851127 253769 WD repeat domain 27 "GO:0005515,GO:0005654" protein binding|nucleoplasm WDR3 812.1055598 993.641893 630.5692266 0.634604107 -0.656071236 0.073707875 1 5.030433479 3.329846539 10885 WD repeat domain 3 "GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0030490,GO:0030515,GO:0031965,GO:0032040,GO:0034388" RNA binding|nucleoplasm|nucleolus|rRNA processing|maturation of SSU-rRNA|snoRNA binding|nuclear membrane|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome hsa03008 Ribosome biogenesis in eukaryotes WDR31 186.9463771 184.7219862 189.170768 1.024083661 0.034333579 0.960850662 1 1.900755169 2.03038103 114987 WD repeat domain 31 WDR33 1254.396003 1223.021942 1285.770064 1.051305802 0.072182379 0.833696 1 3.99830537 4.384508852 55339 WD repeat domain 33 "GO:0000398,GO:0001650,GO:0003723,GO:0005581,GO:0005634,GO:0005654,GO:0005847,GO:0006301,GO:0006369,GO:0006378,GO:0006406,GO:0007283,GO:0031124" "mRNA splicing, via spliceosome|fibrillar center|RNA binding|collagen trimer|nucleus|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|postreplication repair|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA export from nucleus|spermatogenesis|mRNA 3'-end processing" hsa03015 mRNA surveillance pathway WDR35 586.7502001 607.9586251 565.5417751 0.930230696 -0.104339547 0.793981715 1 4.440576811 4.308697284 57539 WD repeat domain 35 "GO:0005515,GO:0005813,GO:0005929,GO:0005930,GO:0009636,GO:0010629,GO:0030991,GO:0032496,GO:0035721,GO:0035735,GO:0036064,GO:0042073,GO:0043065,GO:0043280,GO:0045019,GO:0060271,GO:0061512,GO:0071333,GO:0071356,GO:0090200,GO:0097421,GO:0097542,GO:1905705,GO:1990830" protein binding|centrosome|cilium|axoneme|response to toxic substance|negative regulation of gene expression|intraciliary transport particle A|response to lipopolysaccharide|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of nitric oxide biosynthetic process|cilium assembly|protein localization to cilium|cellular response to glucose stimulus|cellular response to tumor necrosis factor|positive regulation of release of cytochrome c from mitochondria|liver regeneration|ciliary tip|cellular response to paclitaxel|cellular response to leukemia inhibitory factor WDR36 1247.910628 1486.910494 1008.910763 0.678528242 -0.559519231 0.100224028 1 11.73733962 8.307178248 134430 WD repeat domain 36 "GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0007601,GO:0008150,GO:0032040,GO:0034388,GO:0050896" RNA binding|nucleoplasm|nucleolus|rRNA processing|visual perception|biological_process|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome|response to stimulus hsa03008 Ribosome biogenesis in eukaryotes WDR37 500.2535345 453.6853179 546.8217512 1.205288621 0.269378659 0.511113202 1 4.47295325 5.623430671 22884 WD repeat domain 37 "GO:0005634,GO:0005737,GO:0030687" "nucleus|cytoplasm|preribosome, large subunit precursor" WDR4 550.9459092 686.1102346 415.7815838 0.605998224 -0.722614529 0.070603722 1 11.51393735 7.277984786 10785 WD repeat domain 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006400,GO:0006974,GO:0008176,GO:0043527,GO:0106004" protein binding|nucleus|nucleoplasm|chromosome|cytosol|tRNA modification|cellular response to DNA damage stimulus|tRNA (guanine-N7-)-methyltransferase activity|tRNA methyltransferase complex|tRNA (guanine-N7)-methylation WDR41 1195.380099 1095.13749 1295.622708 1.183068537 0.242533653 0.479058767 1 10.71370494 13.22103685 55255 WD repeat domain 41 "GO:0005085,GO:0005515,GO:0005737,GO:0005765,GO:0006914,GO:0010506,GO:0032045,GO:0050790,GO:1990316" guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|lysosomal membrane|autophagy|regulation of autophagy|guanyl-nucleotide exchange factor complex|regulation of catalytic activity|Atg1/ULK1 kinase complex "hsa04140,hsa05014,hsa05022" Autophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases WDR43 903.1452789 1088.032798 718.2577597 0.660143482 -0.599148467 0.095391703 1 15.71734822 10.82264827 23160 WD repeat domain 43 "GO:0000785,GO:0000993,GO:0001650,GO:0003711,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0034243,GO:0045943,GO:2000036,GO:2000234" chromatin|RNA polymerase II complex binding|fibrillar center|transcription elongation regulator activity|RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription by RNA polymerase I|regulation of stem cell population maintenance|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes WDR44 960.2799747 851.5480575 1069.011892 1.255374706 0.328118046 0.35548318 1 10.38726036 13.6016101 54521 WD repeat domain 44 "GO:0005515,GO:0005794,GO:0005829,GO:0010008,GO:0048471" protein binding|Golgi apparatus|cytosol|endosome membrane|perinuclear region of cytoplasm WDR45 1415.675771 1101.227226 1730.124315 1.571087488 0.651763521 0.051531536 1 26.85280408 44.00539695 11152 WD repeat domain 45 "GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005829,GO:0006497,GO:0006914,GO:0009267,GO:0019898,GO:0019901,GO:0032266,GO:0034045,GO:0034497,GO:0044804,GO:0080025,GO:1901981" "autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|cytosol|protein lipidation|autophagy|cellular response to starvation|extrinsic component of membrane|protein kinase binding|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|protein localization to phagophore assembly site|autophagy of nucleus|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol phosphate binding" WDR45B 2085.614258 2344.548287 1826.680228 0.779118195 -0.360085889 0.262646607 1 42.03295563 34.15931912 56270 WD repeat domain 45B "GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005764,GO:0005829,GO:0006497,GO:0009267,GO:0019898,GO:0032266,GO:0034045,GO:0034497,GO:0044804,GO:0062078,GO:0080025" "autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|lysosome|cytosol|protein lipidation|cellular response to starvation|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|protein localization to phagophore assembly site|autophagy of nucleus|TSC1-TSC2 complex binding|phosphatidylinositol-3,5-bisphosphate binding" WDR46 956.3968163 1057.584119 855.2095136 0.808644436 -0.306422611 0.388578858 1 17.195154 14.50372652 9277 WD repeat domain 46 "GO:0000462,GO:0003723,GO:0005575,GO:0005654,GO:0005730,GO:0006364,GO:0032040" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|cellular_component|nucleoplasm|nucleolus|rRNA processing|small-subunit processome" WDR47 577.9179551 543.0014431 612.8344671 1.128605596 0.174541408 0.660431452 1 6.332283559 7.454499384 22911 WD repeat domain 47 "GO:0005515,GO:0005737,GO:0005874,GO:0007275" protein binding|cytoplasm|microtubule|multicellular organism development WDR48 1403.509661 1279.859476 1527.159846 1.193224627 0.254865659 0.446302169 1 13.00047481 16.18070171 57599 WD repeat domain 48 "GO:0000724,GO:0003677,GO:0003690,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005764,GO:0005770,GO:0006974,GO:0007283,GO:0007338,GO:0016032,GO:0016579,GO:0035264,GO:0036297,GO:0042769,GO:0043130,GO:0043231,GO:0043588,GO:0048568,GO:0048705,GO:0048872,GO:0050679,GO:0072520,GO:1902525,GO:1903003,GO:1905168" "double-strand break repair via homologous recombination|DNA binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|lysosome|late endosome|cellular response to DNA damage stimulus|spermatogenesis|single fertilization|viral process|protein deubiquitination|multicellular organism growth|interstrand cross-link repair|DNA damage response, detection of DNA damage|ubiquitin binding|intracellular membrane-bounded organelle|skin development|embryonic organ development|skeletal system morphogenesis|homeostasis of number of cells|positive regulation of epithelial cell proliferation|seminiferous tubule development|regulation of protein monoubiquitination|positive regulation of protein deubiquitination|positive regulation of double-strand break repair via homologous recombination" hsa03460 Fanconi anemia pathway WDR5 1661.176349 1584.346267 1738.006431 1.096986478 0.133545742 0.684515283 1 21.3351633 24.41255166 11091 WD repeat domain 5 "GO:0000123,GO:0001501,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0031175,GO:0035064,GO:0035097,GO:0042393,GO:0042800,GO:0043687,GO:0043966,GO:0043981,GO:0043982,GO:0043984,GO:0044666,GO:0045652,GO:0045722,GO:0048188,GO:0051568,GO:0051571,GO:0051572,GO:0071339" histone acetyltransferase complex|skeletal system development|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|neuron projection development|methylated histone binding|histone methyltransferase complex|histone binding|histone methyltransferase activity (H3-K4 specific)|post-translational protein modification|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|MLL3/4 complex|regulation of megakaryocyte differentiation|positive regulation of gluconeogenesis|Set1C/COMPASS complex|histone H3-K4 methylation|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K4 methylation|MLL1 complex hsa04934 Cushing syndrome other WDR53 246.2673614 232.4249168 260.109806 1.119113259 0.16235605 0.752958547 1 3.716925194 4.338841559 348793 WD repeat domain 53 WDR54 1375.158196 1497.060053 1253.256338 0.837145 -0.256450565 0.444722617 1 63.76855374 55.68307169 84058 WD repeat domain 54 "GO:0002091,GO:0031982,GO:0042058,GO:0042803,GO:0043408" negative regulation of receptor internalization|vesicle|regulation of epidermal growth factor receptor signaling pathway|protein homodimerization activity|regulation of MAPK cascade WDR55 1168.39865 1170.244232 1166.553069 0.996845819 -0.004557713 0.992245394 1 14.13853577 14.70105005 54853 WD repeat domain 55 "GO:0003674,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008150" molecular_function|nucleoplasm|nucleolus|cytoplasm|rRNA processing|biological_process WDR59 858.209352 743.9627248 972.4559791 1.307129977 0.386402605 0.286447768 1 5.982706807 8.15703685 79726 WD repeat domain 59 "GO:0005515,GO:0005765,GO:0032008,GO:0034198,GO:0061700" protein binding|lysosomal membrane|positive regulation of TOR signaling|cellular response to amino acid starvation|GATOR2 complex hsa04150 mTOR signaling pathway WDR5B 189.9142945 219.2304892 160.5980999 0.732553672 -0.448993629 0.414407344 1 2.632973886 2.011879342 54554 WD repeat domain 5B "GO:0042393,GO:0048188,GO:0051568" histone binding|Set1C/COMPASS complex|histone H3-K4 methylation hsa04934 Cushing syndrome WDR6 4355.497702 4017.195723 4693.79968 1.168426934 0.22456752 0.482138675 1 46.89024926 57.14786769 11180 WD repeat domain 6 "GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007050,GO:0008180,GO:0008285,GO:0010507" RNA binding|protein binding|cytoplasm|cytosol|plasma membrane|cell cycle arrest|COP9 signalosome|negative regulation of cell population proliferation|negative regulation of autophagy WDR61 1056.69807 1077.883238 1035.512902 0.960691163 -0.057855378 0.870823529 1 20.95623166 20.99969158 80349 WD repeat domain 61 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006366,GO:0006368,GO:0016055,GO:0016567,GO:0016593,GO:0035327,GO:0043928,GO:0045638,GO:0051571,GO:0055087,GO:0080182,GO:2001162" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|transcriptionally active chromatin|exonucleolytic catabolism of deadenylated mRNA|negative regulation of myeloid cell differentiation|positive regulation of histone H3-K4 methylation|Ski complex|histone H3-K4 trimethylation|positive regulation of histone H3-K79 methylation hsa03018 RNA degradation WDR62 569.0654211 544.016399 594.1144432 1.092089217 0.12709072 0.751265478 1 5.519333221 6.287249042 284403 WD repeat domain 62 "GO:0000922,GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0007052,GO:0007099,GO:0021987,GO:0022008,GO:0034451" spindle pole|protein binding|nucleus|centrosome|centriole|cytosol|mitotic spindle organization|centriole replication|cerebral cortex development|neurogenesis|centriolar satellite WDR7 766.9899998 839.3685858 694.6114137 0.827540398 -0.273098353 0.461777445 1 5.31654049 4.5891712 23335 WD repeat domain 7 GO:0008021 synaptic vesicle WDR70 819.481681 790.6506994 848.3126626 1.072929757 0.101555628 0.78368352 1 18.44480363 20.64245069 55100 WD repeat domain 70 "GO:0005634,GO:0019899,GO:0035861,GO:1903775,GO:2001173" nucleus|enzyme binding|site of double-strand break|regulation of DNA double-strand break processing|regulation of histone H2B conserved C-terminal lysine ubiquitination WDR72 591.1623632 505.4480723 676.8766542 1.33916161 0.421330075 0.283112555 1 3.309951092 4.623496117 256764 WD repeat domain 72 "GO:0005737,GO:0031214,GO:0031410" cytoplasm|biomineral tissue development|cytoplasmic vesicle WDR73 1012.631117 1062.658899 962.603335 0.905844139 -0.142665256 0.686474698 1 10.09565267 9.539021092 84942 WD repeat domain 73 "GO:0000922,GO:0003674,GO:0005829,GO:0006997,GO:0031122,GO:0032154,GO:0043066" spindle pole|molecular_function|cytosol|nucleus organization|cytoplasmic microtubule organization|cleavage furrow|negative regulation of apoptotic process WDR74 687.8652499 717.5738696 658.1566303 0.917197041 -0.124696394 0.744817819 1 16.28252018 15.57758753 54663 WD repeat domain 74 "GO:0000176,GO:0001825,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0016070,GO:0030687,GO:0042273" "nuclear exosome (RNase complex)|blastocyst formation|protein binding|nucleus|nucleoplasm|nucleolus|rRNA processing|RNA metabolic process|preribosome, large subunit precursor|ribosomal large subunit biogenesis" WDR75 951.2087135 972.3278177 930.0896092 0.956559704 -0.064073078 0.859588935 1 11.34676816 11.32140151 84128 WD repeat domain 75 "GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0045943,GO:2000234" RNA binding|nucleoplasm|nucleolus|rRNA processing|positive regulation of transcription by RNA polymerase I|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes WDR76 587.6369873 533.8668394 641.4071352 1.201436553 0.264760463 0.501548386 1 6.788469004 8.507238532 79968 WD repeat domain 76 "GO:0000792,GO:0003677,GO:0005515,GO:0005634,GO:0006974,GO:0019899,GO:0090734,GO:2000001" heterochromatin|DNA binding|protein binding|nucleus|cellular response to DNA damage stimulus|enzyme binding|site of DNA damage|regulation of DNA damage checkpoint WDR77 994.9448541 1200.692911 789.1967977 0.657284465 -0.605410207 0.086462701 1 24.40243183 16.73024905 79084 WD repeat domain 77 "GO:0000387,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006357,GO:0007315,GO:0008284,GO:0008327,GO:0030374,GO:0034709,GO:0045495,GO:0045893,GO:0060528,GO:0060770" "spliceosomal snRNP assembly|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|pole plasm assembly|positive regulation of cell population proliferation|methyl-CpG binding|nuclear receptor coactivator activity|methylosome|pole plasm|positive regulation of transcription, DNA-templated|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|negative regulation of epithelial cell proliferation involved in prostate gland development" WDR81 1035.251621 1194.603175 875.9000663 0.733214246 -0.447693277 0.201381034 1 8.53951115 6.531002263 124997 WD repeat domain 81 "GO:0000421,GO:0005515,GO:0005739,GO:0005765,GO:0005789,GO:0005794,GO:0005829,GO:0006511,GO:0007005,GO:0010923,GO:0031313,GO:0031901,GO:0031902,GO:0035014,GO:0035973,GO:0043551,GO:0045022,GO:0050821,GO:0070530" autophagosome membrane|protein binding|mitochondrion|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|cytosol|ubiquitin-dependent protein catabolic process|mitochondrion organization|negative regulation of phosphatase activity|extrinsic component of endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol 3-kinase regulator activity|aggrephagy|regulation of phosphatidylinositol 3-kinase activity|early endosome to late endosome transport|protein stabilization|K63-linked polyubiquitin modification-dependent protein binding WDR82 4356.876875 4313.562866 4400.190884 1.020082707 0.028686129 0.929143046 1 50.85352463 54.1093571 80335 WD repeat domain 82 "GO:0000781,GO:0000785,GO:0003682,GO:0005515,GO:0005730,GO:0035097,GO:0042800,GO:0048188,GO:0051568,GO:0072357,GO:0080182" "chromosome, telomeric region|chromatin|chromatin binding|protein binding|nucleolus|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|Set1C/COMPASS complex|histone H3-K4 methylation|PTW/PP1 phosphatase complex|histone H3-K4 trimethylation" hsa03015 mRNA surveillance pathway WDR83 173.108138 181.6771183 164.5391576 0.905668028 -0.142945766 0.808556401 1 6.336987001 5.986428264 84292 WD repeat domain 83 "GO:0000165,GO:0000375,GO:0000398,GO:0001666,GO:0005515,GO:0005681,GO:0010008,GO:0032496,GO:0043122,GO:0071013,GO:0090594" "MAPK cascade|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|response to hypoxia|protein binding|spliceosomal complex|endosome membrane|response to lipopolysaccharide|regulation of I-kappaB kinase/NF-kappaB signaling|catalytic step 2 spliceosome|inflammatory response to wounding" WDR83OS 1223.974294 1197.648043 1250.300545 1.043963251 0.062070928 0.85766748 1 62.59716028 68.16411068 51398 WD repeat domain 83 opposite strand "GO:0005515,GO:0016021" protein binding|integral component of membrane WDR89 304.6421753 350.1598091 259.1245416 0.740017943 -0.434367844 0.356771793 1 4.037877742 3.116817294 112840 WD repeat domain 89 WDR90 503.6425769 449.625494 557.6596598 1.24027589 0.310661073 0.447263378 1 3.916069662 5.06622694 197335 WD repeat domain 90 "GO:0005515,GO:0005737,GO:0005814,GO:0060271" protein binding|cytoplasm|centriole|cilium assembly WDR91 271.6857979 286.2175831 257.1540127 0.898456377 -0.154479637 0.756976855 1 3.08883675 2.894728793 29062 WD repeat domain 91 "GO:0005515,GO:0005829,GO:0006511,GO:0031313,GO:0031901,GO:0031902,GO:0035014,GO:0043551,GO:0045022,GO:1903362" protein binding|cytosol|ubiquitin-dependent protein catabolic process|extrinsic component of endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol 3-kinase regulator activity|regulation of phosphatidylinositol 3-kinase activity|early endosome to late endosome transport|regulation of cellular protein catabolic process WDR93 8.015727316 9.134603715 6.896850916 0.755024644 -0.405404361 0.864587159 1 0.094069836 0.074084515 56964 WD repeat domain 93 "GO:0005747,GO:0016651,GO:0022900" "mitochondrial respiratory chain complex I|oxidoreductase activity, acting on NAD(P)H|electron transport chain" WDR97 11.5086901 12.17947162 10.83790858 0.889850473 -0.168365163 0.971008791 1 0.118328654 0.109830482 340390 WD repeat domain 97 WDSUB1 140.6592385 118.7498483 162.5686287 1.369000728 0.453123213 0.456809078 1 1.649550437 2.355511386 151525 "WD repeat, sterile alpha motif and U-box domain containing 1" "GO:0004842,GO:0016567" ubiquitin-protein transferase activity|protein ubiquitination WDTC1 1362.426955 1098.182358 1626.671552 1.481239924 0.56680534 0.0917995 1 10.17732155 15.72442722 23038 WD and tetratricopeptide repeats 1 "GO:0000122,GO:0001701,GO:0004857,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006006,GO:0008361,GO:0016567,GO:0032869,GO:0035264,GO:0042393,GO:0042826,GO:0043086,GO:0043687,GO:0045717,GO:0055082,GO:0080008" negative regulation of transcription by RNA polymerase II|in utero embryonic development|enzyme inhibitor activity|protein binding|nucleoplasm|cytoplasm|cytosol|glucose metabolic process|regulation of cell size|protein ubiquitination|cellular response to insulin stimulus|multicellular organism growth|histone binding|histone deacetylase binding|negative regulation of catalytic activity|post-translational protein modification|negative regulation of fatty acid biosynthetic process|cellular chemical homeostasis|Cul4-RING E3 ubiquitin ligase complex WEE1 789.9616049 692.1999704 887.7232393 1.282466451 0.358921086 0.330074303 1 8.196746918 10.96486953 7465 WEE1 G2 checkpoint kinase "GO:0000086,GO:0000226,GO:0000287,GO:0004672,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0007093,GO:0016301,GO:0018108,GO:0030010,GO:0048812,GO:0051301,GO:2000134" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|magnesium ion binding|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitotic cell cycle checkpoint|kinase activity|peptidyl-tyrosine phosphorylation|establishment of cell polarity|neuron projection morphogenesis|cell division|negative regulation of G1/S transition of mitotic cell cycle "hsa04110,hsa05170" Cell cycle|Human immunodeficiency virus 1 infection WFDC10B 3.537500113 6.08973581 0.985264417 0.161790995 -2.627796782 0.2971307 1 0.291240449 0.049149824 280664 WAP four-disulfide core domain 10B "GO:0004867,GO:0005515,GO:0005615,GO:0010951,GO:0019731,GO:0045087" serine-type endopeptidase inhibitor activity|protein binding|extracellular space|negative regulation of endopeptidase activity|antibacterial humoral response|innate immune response WFDC2 964.9912828 1476.760934 453.2216316 0.306902506 -1.704147668 2.84E-06 0.000941516 131.9095796 42.2272404 10406 WAP four-disulfide core domain 2 "GO:0004866,GO:0004867,GO:0004869,GO:0005515,GO:0005615,GO:0006508,GO:0007283,GO:0010951,GO:0019731,GO:0019828,GO:0045087,GO:0070062" endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|protein binding|extracellular space|proteolysis|spermatogenesis|negative regulation of endopeptidase activity|antibacterial humoral response|aspartic-type endopeptidase inhibitor activity|innate immune response|extracellular exosome WFDC3 28.76294156 46.68797455 10.83790858 0.232134906 -2.106964619 0.041673897 0.936729674 1.903849602 0.46098736 140686 WAP four-disulfide core domain 3 "GO:0004867,GO:0005515,GO:0005615,GO:0010951,GO:0019731,GO:0045087" serine-type endopeptidase inhibitor activity|protein binding|extracellular space|negative regulation of endopeptidase activity|antibacterial humoral response|innate immune response WFIKKN1 4.015286546 5.074779842 2.95579325 0.582447582 -0.779799875 0.804328363 1 0.130070696 0.079022769 117166 "WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1" "GO:0001501,GO:0004867,GO:0005515,GO:0005576,GO:0008191,GO:0010951,GO:0030512,GO:0032091,GO:0043392,GO:0048019,GO:0048747,GO:0050431,GO:0060021,GO:2000272" skeletal system development|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|metalloendopeptidase inhibitor activity|negative regulation of endopeptidase activity|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of protein binding|negative regulation of DNA binding|receptor antagonist activity|muscle fiber development|transforming growth factor beta binding|roof of mouth development|negative regulation of signaling receptor activity WFS1 583.933462 550.1061349 617.7607892 1.12298473 0.16733831 0.673017631 1 7.362826393 8.624508231 7466 wolframin ER transmembrane glycoprotein "GO:0000122,GO:0001822,GO:0003091,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0006983,GO:0007601,GO:0007605,GO:0022417,GO:0030176,GO:0030425,GO:0030433,GO:0030968,GO:0031398,GO:0031625,GO:0032469,GO:0034976,GO:0036498,GO:0042593,GO:0043069,GO:0043433,GO:0043524,GO:0043687,GO:0044267,GO:0045927,GO:0050821,GO:0050877,GO:0051117,GO:0051247,GO:0051928,GO:0055074,GO:1903892,GO:2000675" negative regulation of transcription by RNA polymerase II|kidney development|renal water homeostasis|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER overload response|visual perception|sensory perception of sound|protein maturation by protein folding|integral component of endoplasmic reticulum membrane|dendrite|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|endoplasmic reticulum calcium ion homeostasis|response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|glucose homeostasis|negative regulation of programmed cell death|negative regulation of DNA-binding transcription factor activity|negative regulation of neuron apoptotic process|post-translational protein modification|cellular protein metabolic process|positive regulation of growth|protein stabilization|nervous system process|ATPase binding|positive regulation of protein metabolic process|positive regulation of calcium ion transport|calcium ion homeostasis|negative regulation of ATF6-mediated unfolded protein response|negative regulation of type B pancreatic cell apoptotic process hsa04141 Protein processing in endoplasmic reticulum WHAMM 605.5174829 577.509946 633.5250198 1.096994128 0.133555804 0.734911673 1 5.802190326 6.639145758 123720 "WASP homolog associated with actin, golgi membranes and microtubules" "GO:0000139,GO:0003779,GO:0005737,GO:0005829,GO:0005874,GO:0006888,GO:0007015,GO:0007050,GO:0008017,GO:0030032,GO:0030659,GO:0031267,GO:0033116,GO:0034314,GO:0048041,GO:0051127,GO:0071933,GO:0090527,GO:0097320" Golgi membrane|actin binding|cytoplasm|cytosol|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|actin filament organization|cell cycle arrest|microtubule binding|lamellipodium assembly|cytoplasmic vesicle membrane|small GTPase binding|endoplasmic reticulum-Golgi intermediate compartment membrane|Arp2/3 complex-mediated actin nucleation|focal adhesion assembly|positive regulation of actin nucleation|Arp2/3 complex binding|actin filament reorganization|plasma membrane tubulation hsa04530 Tight junction WHRN 131.029281 133.9741878 128.0843742 0.956037698 -0.064860588 0.929289493 1 1.041172316 1.038277778 25861 whirlin "GO:0001895,GO:0001917,GO:0002141,GO:0002142,GO:0005515,GO:0005737,GO:0005884,GO:0005886,GO:0007605,GO:0010628,GO:0021694,GO:0030426,GO:0032391,GO:0032420,GO:0032426,GO:0036064,GO:0042802,GO:0043025,GO:0045184,GO:0045202,GO:0050910,GO:0050953,GO:0060088,GO:0060122,GO:1990075,GO:1990227,GO:1990696" retina homeostasis|photoreceptor inner segment|stereocilia ankle link|stereocilia ankle link complex|protein binding|cytoplasm|actin filament|plasma membrane|sensory perception of sound|positive regulation of gene expression|cerebellar Purkinje cell layer formation|growth cone|photoreceptor connecting cilium|stereocilium|stereocilium tip|ciliary basal body|identical protein binding|neuronal cell body|establishment of protein localization|synapse|detection of mechanical stimulus involved in sensory perception of sound|sensory perception of light stimulus|auditory receptor cell stereocilium organization|inner ear receptor cell stereocilium organization|periciliary membrane compartment|paranodal junction maintenance|USH2 complex WIPF1 5.059934066 9.134603715 0.985264417 0.107860663 -3.212759283 0.136251646 1 0.078867278 0.00887311 7456 WAS/WASL interacting protein family member 1 "GO:0001726,GO:0003779,GO:0005515,GO:0005522,GO:0005829,GO:0005884,GO:0008154,GO:0015629,GO:0017124,GO:0030048,GO:0031410,GO:0038096,GO:0051707,GO:0065003" ruffle|actin binding|protein binding|profilin binding|cytosol|actin filament|actin polymerization or depolymerization|actin cytoskeleton|SH3 domain binding|actin filament-based movement|cytoplasmic vesicle|Fc-gamma receptor signaling pathway involved in phagocytosis|response to other organism|protein-containing complex assembly "hsa04144,hsa05130,hsa05135" Endocytosis|Pathogenic Escherichia coli infection|Yersinia infection WIPF2 1548.97225 1625.959461 1471.985038 0.905302422 -0.143528281 0.66477757 1 10.76740464 10.16765136 147179 WAS/WASL interacting protein family member 2 "GO:0003779,GO:0005515,GO:0005654,GO:0005829,GO:0005884,GO:0005886,GO:0030048,GO:0038096" actin binding|protein binding|nucleoplasm|cytosol|actin filament|plasma membrane|actin filament-based movement|Fc-gamma receptor signaling pathway involved in phagocytosis "hsa04144,hsa05130,hsa05135" Endocytosis|Pathogenic Escherichia coli infection|Yersinia infection WIPF3 52.96402448 17.25425146 88.67379749 5.139243373 2.361555974 0.007040792 0.341973728 0.193805049 1.038915443 644150 WAS/WASL interacting protein family member 3 "GO:0003779,GO:0005829,GO:0005884,GO:0007275,GO:0007283,GO:0017124,GO:0030048,GO:0030154,GO:0038096" actin binding|cytosol|actin filament|multicellular organism development|spermatogenesis|SH3 domain binding|actin filament-based movement|cell differentiation|Fc-gamma receptor signaling pathway involved in phagocytosis "hsa04144,hsa05130,hsa05135" Endocytosis|Pathogenic Escherichia coli infection|Yersinia infection WIPI1 1076.881145 1076.868282 1076.894007 1.000023889 3.45E-05 1 1 12.68952525 13.23645473 55062 "WD repeat domain, phosphoinositide interacting 1" "GO:0000045,GO:0000139,GO:0000407,GO:0000421,GO:0000422,GO:0005102,GO:0005515,GO:0005737,GO:0005802,GO:0005829,GO:0005856,GO:0006497,GO:0006914,GO:0009267,GO:0010008,GO:0016236,GO:0019898,GO:0030136,GO:0030331,GO:0032266,GO:0034045,GO:0034497,GO:0036498,GO:0044804,GO:0048203,GO:0050681,GO:0080025" "autophagosome assembly|Golgi membrane|phagophore assembly site|autophagosome membrane|autophagy of mitochondrion|signaling receptor binding|protein binding|cytoplasm|trans-Golgi network|cytosol|cytoskeleton|protein lipidation|autophagy|cellular response to starvation|endosome membrane|macroautophagy|extrinsic component of membrane|clathrin-coated vesicle|estrogen receptor binding|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|protein localization to phagophore assembly site|IRE1-mediated unfolded protein response|autophagy of nucleus|vesicle targeting, trans-Golgi to endosome|androgen receptor binding|phosphatidylinositol-3,5-bisphosphate binding" "hsa04136,hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131" Autophagy - other|Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis WIPI2 3270.083949 2862.175831 3677.992067 1.285033584 0.361806065 0.255515314 1 30.8883675 41.40238539 26100 "WD repeat domain, phosphoinositide interacting 2" "GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005654,GO:0005776,GO:0005829,GO:0006497,GO:0009267,GO:0016020,GO:0016236,GO:0019898,GO:0032266,GO:0032991,GO:0034045,GO:0034497,GO:0044804,GO:0061739,GO:0080025,GO:0097352,GO:0098792" "autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|nucleoplasm|autophagosome|cytosol|protein lipidation|cellular response to starvation|membrane|macroautophagy|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|protein-containing complex|phagophore assembly site membrane|protein localization to phagophore assembly site|autophagy of nucleus|protein lipidation involved in autophagosome assembly|phosphatidylinositol-3,5-bisphosphate binding|autophagosome maturation|xenophagy" "hsa04136,hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131" Autophagy - other|Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis WIZ 910.2487329 933.7594909 886.7379749 0.949642797 -0.074543141 0.837808779 1 4.504393191 4.461824682 58525 WIZ zinc finger "GO:0000978,GO:0000981,GO:0001226,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0010571,GO:0030496,GO:0044877,GO:0046872,GO:0050821,GO:0070062,GO:1990226" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription corepressor binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of nuclear cell cycle DNA replication|midbody|protein-containing complex binding|metal ion binding|protein stabilization|extracellular exosome|histone methyltransferase binding" WLS 1864.685907 1857.369422 1872.002391 1.00787833 0.011321489 0.973946828 1 29.50728006 31.02081589 79971 Wnt ligand secretion mediator "GO:0000139,GO:0005515,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0009948,GO:0012505,GO:0016055,GO:0017147,GO:0030177,GO:0030666,GO:0031301,GO:0031410,GO:0031852,GO:0031901,GO:0032590,GO:0032839,GO:0043123,GO:0061355,GO:0061357,GO:0070062,GO:0090263" Golgi membrane|protein binding|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|anterior/posterior axis specification|endomembrane system|Wnt signaling pathway|Wnt-protein binding|positive regulation of Wnt signaling pathway|endocytic vesicle membrane|integral component of organelle membrane|cytoplasmic vesicle|mu-type opioid receptor binding|early endosome membrane|dendrite membrane|dendrite cytoplasm|positive regulation of I-kappaB kinase/NF-kappaB signaling|Wnt protein secretion|positive regulation of Wnt protein secretion|extracellular exosome|positive regulation of canonical Wnt signaling pathway WNK1 7391.836205 7233.591187 7550.081224 1.043752823 0.0617801 0.851226662 1 28.06679499 30.55669754 65125 WNK lysine deficient protein kinase 1 "GO:0002028,GO:0004672,GO:0004674,GO:0004860,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006469,GO:0006811,GO:0007165,GO:0010766,GO:0010820,GO:0010923,GO:0016020,GO:0018105,GO:0018107,GO:0019869,GO:0019870,GO:0019901,GO:0019902,GO:0030295,GO:0032147,GO:0033633,GO:0034115,GO:0034260,GO:0035556,GO:0038116,GO:0048666,GO:0050794,GO:0050801,GO:0050852,GO:0090263,GO:0097022,GO:0106310,GO:0106311,GO:1903038,GO:1903288,GO:1904062,GO:1990869,GO:2000651" regulation of sodium ion transport|protein kinase activity|protein serine/threonine kinase activity|protein kinase inhibitor activity|protein binding|ATP binding|cytoplasm|cytosol|protein phosphorylation|negative regulation of protein kinase activity|ion transport|signal transduction|negative regulation of sodium ion transport|positive regulation of T cell chemotaxis|negative regulation of phosphatase activity|membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|chloride channel inhibitor activity|potassium channel inhibitor activity|protein kinase binding|phosphatase binding|protein kinase activator activity|activation of protein kinase activity|negative regulation of cell-cell adhesion mediated by integrin|negative regulation of heterotypic cell-cell adhesion|negative regulation of GTPase activity|intracellular signal transduction|chemokine (C-C motif) ligand 21 signaling pathway|neuron development|regulation of cellular process|ion homeostasis|T cell receptor signaling pathway|positive regulation of canonical Wnt signaling pathway|lymphocyte migration into lymph node|protein serine kinase activity|protein threonine kinase activity|negative regulation of leukocyte cell-cell adhesion|positive regulation of potassium ion import across plasma membrane|regulation of cation transmembrane transport|cellular response to chemokine|positive regulation of sodium ion transmembrane transporter activity WNK4 861.0166875 733.8131651 988.2202098 1.346691851 0.429419772 0.235857585 1 7.126567225 10.01070234 65266 WNK lysine deficient protein kinase 4 "GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005923,GO:0006468,GO:0006811,GO:0006821,GO:0008104,GO:0010766,GO:0016020,GO:0019869,GO:0019870,GO:0035556,GO:0050794,GO:0050801,GO:0070294,GO:0072156,GO:0090188,GO:0106310,GO:0106311,GO:1903288,GO:2000651" protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|bicellular tight junction|protein phosphorylation|ion transport|chloride transport|protein localization|negative regulation of sodium ion transport|membrane|chloride channel inhibitor activity|potassium channel inhibitor activity|intracellular signal transduction|regulation of cellular process|ion homeostasis|renal sodium ion absorption|distal tubule morphogenesis|negative regulation of pancreatic juice secretion|protein serine kinase activity|protein threonine kinase activity|positive regulation of potassium ion import across plasma membrane|positive regulation of sodium ion transmembrane transporter activity WNT10B 18.64307343 28.41876711 8.867379749 0.312025491 -1.680264202 0.146698393 1 0.456055228 0.1484306 7480 Wnt family member 10B "GO:0000086,GO:0000122,GO:0002062,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0006629,GO:0007050,GO:0007224,GO:0008284,GO:0010971,GO:0014835,GO:0016055,GO:0030182,GO:0030501,GO:0030858,GO:0032434,GO:0043065,GO:0045165,GO:0045599,GO:0045669,GO:0045899,GO:0048018,GO:0048641,GO:0048741,GO:0050680,GO:0050821,GO:0050909,GO:0051091,GO:0051885,GO:0060070,GO:0060346,GO:0061196,GO:0071300,GO:0071320,GO:0071374,GO:0071425,GO:0090263,GO:0120163" G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chondrocyte differentiation|frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|lipid metabolic process|cell cycle arrest|smoothened signaling pathway|positive regulation of cell population proliferation|positive regulation of G2/M transition of mitotic cell cycle|myoblast differentiation involved in skeletal muscle regeneration|Wnt signaling pathway|neuron differentiation|positive regulation of bone mineralization|positive regulation of epithelial cell differentiation|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of apoptotic process|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of RNA polymerase II transcription preinitiation complex assembly|receptor ligand activity|regulation of skeletal muscle tissue development|skeletal muscle fiber development|negative regulation of epithelial cell proliferation|protein stabilization|sensory perception of taste|positive regulation of DNA-binding transcription factor activity|positive regulation of timing of anagen|canonical Wnt signaling pathway|bone trabecula formation|fungiform papilla development|cellular response to retinoic acid|cellular response to cAMP|cellular response to parathyroid hormone stimulus|hematopoietic stem cell proliferation|positive regulation of canonical Wnt signaling pathway|negative regulation of cold-induced thermogenesis "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT11 6.537830691 9.134603715 3.941057666 0.431442654 -1.212759283 0.49852985 1 0.184832382 0.083179646 7481 Wnt family member 11 "GO:0001649,GO:0001837,GO:0003138,GO:0003139,GO:0003151,GO:0003283,GO:0003402,GO:0005096,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0006468,GO:0007223,GO:0010628,GO:0016055,GO:0030182,GO:0030282,GO:0030295,GO:0030308,GO:0030325,GO:0030335,GO:0030336,GO:0031012,GO:0031667,GO:0032147,GO:0032915,GO:0034394,GO:0043065,GO:0043066,GO:0043547,GO:0045165,GO:0045199,GO:0045892,GO:0045893,GO:0048341,GO:0048570,GO:0048706,GO:0048844,GO:0051496,GO:0060028,GO:0060070,GO:0060071,GO:0060197,GO:0060412,GO:0060484,GO:0060548,GO:0060675,GO:0060775,GO:0061037,GO:0061053,GO:0061101,GO:0062009,GO:0070830,GO:0071260,GO:0071300,GO:0072177,GO:0072201,GO:0090037,GO:0090082,GO:0090090,GO:0090272" "osteoblast differentiation|epithelial to mesenchymal transition|primary heart field specification|secondary heart field specification|outflow tract morphogenesis|atrial septum development|planar cell polarity pathway involved in axis elongation|GTPase activator activity|frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|cytoplasm|protein phosphorylation|Wnt signaling pathway, calcium modulating pathway|positive regulation of gene expression|Wnt signaling pathway|neuron differentiation|bone mineralization|protein kinase activator activity|negative regulation of cell growth|adrenal gland development|positive regulation of cell migration|negative regulation of cell migration|extracellular matrix|response to nutrient levels|activation of protein kinase activity|positive regulation of transforming growth factor beta2 production|protein localization to cell surface|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of GTPase activity|cell fate commitment|maintenance of epithelial cell apical/basal polarity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|paraxial mesoderm formation|notochord morphogenesis|embryonic skeletal system development|artery morphogenesis|positive regulation of stress fiber assembly|convergent extension involved in axis elongation|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|cloacal septation|ventricular septum morphogenesis|lung-associated mesenchyme development|negative regulation of cell death|ureteric bud morphogenesis|planar cell polarity pathway involved in gastrula mediolateral intercalation|negative regulation of cartilage development|somite development|neuroendocrine cell differentiation|secondary palate development|bicellular tight junction assembly|cellular response to mechanical stimulus|cellular response to retinoic acid|mesonephric duct development|negative regulation of mesenchymal cell proliferation|positive regulation of protein kinase C signaling|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|negative regulation of fibroblast growth factor production" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT2B 167.006278 134.9891438 199.0234121 1.47436606 0.560094766 0.328443249 1 0.558008808 0.858148226 7482 Wnt family member 2B "GO:0002062,GO:0002088,GO:0005109,GO:0005125,GO:0005576,GO:0005615,GO:0008584,GO:0009267,GO:0016055,GO:0021871,GO:0030182,GO:0043231,GO:0045165,GO:0060070,GO:0060492,GO:0060638,GO:0061072,GO:0061303,GO:0062023,GO:0071425,GO:0090190" chondrocyte differentiation|lens development in camera-type eye|frizzled binding|cytokine activity|extracellular region|extracellular space|male gonad development|cellular response to starvation|Wnt signaling pathway|forebrain regionalization|neuron differentiation|intracellular membrane-bounded organelle|cell fate commitment|canonical Wnt signaling pathway|lung induction|mesenchymal-epithelial cell signaling|iris morphogenesis|cornea development in camera-type eye|collagen-containing extracellular matrix|hematopoietic stem cell proliferation|positive regulation of branching involved in ureteric bud morphogenesis "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT3 355.7774478 276.0680234 435.4868721 1.577462202 0.657605437 0.143216736 1 4.253687702 6.999072516 7473 Wnt family member 3 "GO:0000902,GO:0001707,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0007276,GO:0007411,GO:0009948,GO:0009950,GO:0010628,GO:0016055,GO:0019904,GO:0030177,GO:0030182,GO:0030666,GO:0031012,GO:0035115,GO:0035116,GO:0044338,GO:0044339,GO:0045165,GO:0048018,GO:0048697,GO:0048843,GO:0050767,GO:0060064,GO:0060070,GO:0060174,GO:0060323,GO:0061180,GO:0070062,GO:0071300,GO:0072089,GO:1904954,GO:1905474,GO:1990909" cell morphogenesis|mesoderm formation|frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|gamete generation|axon guidance|anterior/posterior axis specification|dorsal/ventral axis specification|positive regulation of gene expression|Wnt signaling pathway|protein domain specific binding|positive regulation of Wnt signaling pathway|neuron differentiation|endocytic vesicle membrane|extracellular matrix|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt signaling pathway involved in osteoblast differentiation|cell fate commitment|receptor ligand activity|positive regulation of collateral sprouting in absence of injury|negative regulation of axon extension involved in axon guidance|regulation of neurogenesis|Spemann organizer formation at the anterior end of the primitive streak|canonical Wnt signaling pathway|limb bud formation|head morphogenesis|mammary gland epithelium development|extracellular exosome|cellular response to retinoic acid|stem cell proliferation|canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|canonical Wnt signaling pathway involved in stem cell proliferation|Wnt signalosome "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05206,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT5A 104.0263058 106.5703767 101.4822349 0.952255571 -0.070579272 0.930780198 1 0.366647213 0.364181466 7474 Wnt family member 5A "GO:0000187,GO:0001736,GO:0001756,GO:0001822,GO:0001837,GO:0001938,GO:0001947,GO:0002053,GO:0002088,GO:0002720,GO:0003138,GO:0003139,GO:0003283,GO:0003323,GO:0003402,GO:0003408,GO:0005109,GO:0005115,GO:0005125,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0006468,GO:0007223,GO:0007257,GO:0007411,GO:0007442,GO:0007494,GO:0008584,GO:0008595,GO:0009986,GO:0010033,GO:0010595,GO:0010628,GO:0010800,GO:0010820,GO:0010976,GO:0016055,GO:0019904,GO:0021891,GO:0030182,GO:0030216,GO:0030324,GO:0030514,GO:0030665,GO:0030666,GO:0030669,GO:0032092,GO:0032148,GO:0032722,GO:0032729,GO:0032731,GO:0032755,GO:0032757,GO:0032760,GO:0033138,GO:0034613,GO:0035567,GO:0036342,GO:0036517,GO:0036518,GO:0038031,GO:0040037,GO:0042060,GO:0042733,GO:0043032,GO:0043066,GO:0043122,GO:0045165,GO:0045198,GO:0045599,GO:0045732,GO:0045766,GO:0045778,GO:0045807,GO:0045836,GO:0045892,GO:0045893,GO:0045944,GO:0046330,GO:0048018,GO:0048022,GO:0048146,GO:0048341,GO:0048570,GO:0048706,GO:0048806,GO:0048843,GO:0048850,GO:0050680,GO:0050727,GO:0050729,GO:0050807,GO:0051092,GO:0051216,GO:0051885,GO:0051964,GO:0060028,GO:0060029,GO:0060065,GO:0060067,GO:0060068,GO:0060070,GO:0060071,GO:0060157,GO:0060324,GO:0060340,GO:0060599,GO:0060638,GO:0060686,GO:0060744,GO:0060750,GO:0060760,GO:0060762,GO:0060775,GO:0060809,GO:0060907,GO:0061024,GO:0061036,GO:0061347,GO:0061348,GO:0061349,GO:0061350,GO:0061354,GO:0062009,GO:0062023,GO:0070062,GO:0070245,GO:0071222,GO:0071277,GO:0071300,GO:0071346,GO:0071425,GO:0071560,GO:0072201,GO:0090009,GO:0090037,GO:0090082,GO:0090090,GO:0090103,GO:0090179,GO:0090630,GO:0097325,GO:0098794,GO:0098978,GO:0099054,GO:0099068,GO:0099175,GO:0099566,GO:0150012,GO:1900020,GO:1901216,GO:1902379,GO:1902474,GO:1903827,GO:1904861,GO:1904862,GO:1904934,GO:1904938,GO:1904953,GO:1904955,GO:2000049,GO:2000052" "activation of MAPK activity|establishment of planar polarity|somitogenesis|kidney development|epithelial to mesenchymal transition|positive regulation of endothelial cell proliferation|heart looping|positive regulation of mesenchymal cell proliferation|lens development in camera-type eye|positive regulation of cytokine production involved in immune response|primary heart field specification|secondary heart field specification|atrial septum development|type B pancreatic cell development|planar cell polarity pathway involved in axis elongation|optic cup formation involved in camera-type eye development|frizzled binding|receptor tyrosine kinase-like orphan receptor binding|cytokine activity|protein binding|phospholipid binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|protein phosphorylation|Wnt signaling pathway, calcium modulating pathway|activation of JUN kinase activity|axon guidance|hindgut morphogenesis|midgut development|male gonad development|anterior/posterior axis specification, embryo|cell surface|response to organic substance|positive regulation of endothelial cell migration|positive regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|positive regulation of T cell chemotaxis|positive regulation of neuron projection development|Wnt signaling pathway|protein domain specific binding|olfactory bulb interneuron development|neuron differentiation|keratinocyte differentiation|lung development|negative regulation of BMP signaling pathway|clathrin-coated vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|positive regulation of protein binding|activation of protein kinase B activity|positive regulation of chemokine production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of peptidyl-serine phosphorylation|cellular protein localization|non-canonical Wnt signaling pathway|post-anal tail morphogenesis|chemoattraction of serotonergic neuron axon|chemorepulsion of dopaminergic neuron axon|non-canonical Wnt signaling pathway via JNK cascade|negative regulation of fibroblast growth factor receptor signaling pathway|wound healing|embryonic digit morphogenesis|positive regulation of macrophage activation|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|cell fate commitment|establishment of epithelial cell apical/basal polarity|negative regulation of fat cell differentiation|positive regulation of protein catabolic process|positive regulation of angiogenesis|positive regulation of ossification|positive regulation of endocytosis|positive regulation of meiotic nuclear division|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|receptor ligand activity|negative regulation of melanin biosynthetic process|positive regulation of fibroblast proliferation|paraxial mesoderm formation|notochord morphogenesis|embryonic skeletal system development|genitalia development|negative regulation of axon extension involved in axon guidance|hypophysis morphogenesis|negative regulation of epithelial cell proliferation|regulation of inflammatory response|positive regulation of inflammatory response|regulation of synapse organization|positive regulation of NF-kappaB transcription factor activity|cartilage development|positive regulation of timing of anagen|negative regulation of synapse assembly|convergent extension involved in axis elongation|convergent extension involved in organogenesis|uterus development|cervix development|vagina development|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|urinary bladder development|face development|positive regulation of type I interferon-mediated signaling pathway|lateral sprouting involved in mammary gland duct morphogenesis|mesenchymal-epithelial cell signaling|negative regulation of prostatic bud formation|mammary gland branching involved in thelarche|epithelial cell proliferation involved in mammary gland duct elongation|positive regulation of response to cytokine stimulus|regulation of branching involved in mammary gland duct morphogenesis|planar cell polarity pathway involved in gastrula mediolateral intercalation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of macrophage cytokine production|membrane organization|positive regulation of cartilage development|planar cell polarity pathway involved in outflow tract morphogenesis|planar cell polarity pathway involved in ventricular septum morphogenesis|planar cell polarity pathway involved in cardiac right atrium morphogenesis|planar cell polarity pathway involved in cardiac muscle tissue morphogenesis|planar cell polarity pathway involved in pericardium morphogenesis|secondary palate development|collagen-containing extracellular matrix|extracellular exosome|positive regulation of thymocyte apoptotic process|cellular response to lipopolysaccharide|cellular response to calcium ion|cellular response to retinoic acid|cellular response to interferon-gamma|hematopoietic stem cell proliferation|cellular response to transforming growth factor beta stimulus|negative regulation of mesenchymal cell proliferation|primitive streak formation|positive regulation of protein kinase C signaling|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|activation of GTPase activity|melanocyte proliferation|postsynapse|glutamatergic synapse|presynapse assembly|postsynapse assembly|regulation of postsynapse organization|regulation of postsynaptic cytosolic calcium ion concentration|positive regulation of neuron projection arborization|positive regulation of protein kinase C activity|positive regulation of neuron death|chemoattractant activity involved in axon guidance|positive regulation of protein localization to synapse|regulation of cellular protein localization|excitatory synapse assembly|inhibitory synapse assembly|negative regulation of cell proliferation in midbrain|planar cell polarity pathway involved in axon guidance|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of cell-cell adhesion mediated by cadherin|positive regulation of non-canonical Wnt signaling pathway" "hsa04150,hsa04310,hsa04360,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT5B 993.5901752 602.8838452 1384.296505 2.296124728 1.199201013 0.000780452 0.079140395 7.877693476 18.86733166 81029 Wnt family member 5B "GO:0002062,GO:0005102,GO:0005109,GO:0005125,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0016055,GO:0030182,GO:0030335,GO:0030666,GO:0042060,GO:0042692,GO:0045165,GO:0045444,GO:0060070,GO:0062023,GO:0070062,GO:0070307,GO:0071300,GO:1904105,GO:2000052" chondrocyte differentiation|signaling receptor binding|frizzled binding|cytokine activity|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|Wnt signaling pathway|neuron differentiation|positive regulation of cell migration|endocytic vesicle membrane|wound healing|muscle cell differentiation|cell fate commitment|fat cell differentiation|canonical Wnt signaling pathway|collagen-containing extracellular matrix|extracellular exosome|lens fiber cell development|cellular response to retinoic acid|positive regulation of convergent extension involved in gastrulation|positive regulation of non-canonical Wnt signaling pathway "hsa04150,hsa04310,hsa04360,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT7A 72.43573976 136.0040998 8.867379749 0.065199356 -3.93899847 7.91E-06 0.002101887 1.674314015 0.113866547 7476 Wnt family member 7A "GO:0000578,GO:0001502,GO:0001525,GO:0002062,GO:0005102,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0007269,GO:0007409,GO:0007548,GO:0009953,GO:0009986,GO:0010595,GO:0014719,GO:0014834,GO:0016055,GO:0021707,GO:0021846,GO:0022009,GO:0030010,GO:0030182,GO:0030666,GO:0031012,GO:0031133,GO:0032270,GO:0032355,GO:0035019,GO:0035115,GO:0035116,GO:0035313,GO:0036465,GO:0042733,GO:0043066,GO:0043627,GO:0045165,GO:0045167,GO:0045893,GO:0045944,GO:0046330,GO:0048018,GO:0048103,GO:0048864,GO:0050768,GO:0051965,GO:0060054,GO:0060066,GO:0060070,GO:0060071,GO:0060997,GO:0061038,GO:0062009,GO:0070062,GO:0070307,GO:0071560,GO:0098685,GO:0098793,GO:0098978,GO:0099054,GO:0099068,GO:0099175,GO:1904861,GO:1904891,GO:1905386,GO:1905606,GO:2000300,GO:2000463" "embryonic axis specification|cartilage condensation|angiogenesis|chondrocyte differentiation|signaling receptor binding|frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|neurotransmitter secretion|axonogenesis|sex differentiation|dorsal/ventral pattern formation|cell surface|positive regulation of endothelial cell migration|skeletal muscle satellite cell activation|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|Wnt signaling pathway|cerebellar granule cell differentiation|cell proliferation in forebrain|central nervous system vasculogenesis|establishment of cell polarity|neuron differentiation|endocytic vesicle membrane|extracellular matrix|regulation of axon diameter|positive regulation of cellular protein metabolic process|response to estradiol|somatic stem cell population maintenance|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|wound healing, spreading of epidermal cells|synaptic vesicle recycling|embryonic digit morphogenesis|negative regulation of apoptotic process|response to estrogen|cell fate commitment|asymmetric protein localization involved in cell fate determination|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|receptor ligand activity|somatic stem cell division|stem cell development|negative regulation of neurogenesis|positive regulation of synapse assembly|positive regulation of epithelial cell proliferation involved in wound healing|oviduct development|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|dendritic spine morphogenesis|uterus morphogenesis|secondary palate development|extracellular exosome|lens fiber cell development|cellular response to transforming growth factor beta stimulus|Schaffer collateral - CA1 synapse|presynapse|glutamatergic synapse|presynapse assembly|postsynapse assembly|regulation of postsynapse organization|excitatory synapse assembly|positive regulation of excitatory synapse assembly|positive regulation of protein localization to presynapse|regulation of presynapse assembly|regulation of synaptic vesicle exocytosis|positive regulation of excitatory postsynaptic potential" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT7B 288.3001972 479.0592171 97.54117724 0.203609854 -2.296120711 4.98E-06 0.001435401 5.829567353 1.238086667 7477 Wnt family member 7B "GO:0001701,GO:0003338,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0016055,GO:0016332,GO:0021871,GO:0022009,GO:0030182,GO:0030324,GO:0030666,GO:0032364,GO:0042592,GO:0044237,GO:0045165,GO:0045669,GO:0046330,GO:0048018,GO:0048144,GO:0048568,GO:0050808,GO:0060070,GO:0060425,GO:0060428,GO:0060482,GO:0060535,GO:0060560,GO:0060669,GO:0060710,GO:0061180,GO:0070062,GO:0070307,GO:0071300,GO:0072053,GO:0072054,GO:0072060,GO:0072061,GO:0072089,GO:0072205,GO:0072207,GO:0072236" in utero embryonic development|metanephros morphogenesis|frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|Wnt signaling pathway|establishment or maintenance of polarity of embryonic epithelium|forebrain regionalization|central nervous system vasculogenesis|neuron differentiation|lung development|endocytic vesicle membrane|oxygen homeostasis|homeostatic process|cellular metabolic process|cell fate commitment|positive regulation of osteoblast differentiation|positive regulation of JNK cascade|receptor ligand activity|fibroblast proliferation|embryonic organ development|synapse organization|canonical Wnt signaling pathway|lung morphogenesis|lung epithelium development|lobar bronchus development|trachea cartilage morphogenesis|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|chorio-allantoic fusion|mammary gland epithelium development|extracellular exosome|lens fiber cell development|cellular response to retinoic acid|renal inner medulla development|renal outer medulla development|outer medullary collecting duct development|inner medullary collecting duct development|stem cell proliferation|metanephric collecting duct development|metanephric epithelium development|metanephric loop of Henle development "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT9A 99.53323281 102.5105528 96.55591282 0.941911932 -0.08633592 0.913587698 1 1.11149601 1.092028911 7483 Wnt family member 9A "GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0007267,GO:0007275,GO:0008285,GO:0016055,GO:0030182,GO:0032331,GO:0045165,GO:0048018,GO:0060070,GO:0061072,GO:0061303,GO:0071300,GO:0072498" frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|cell-cell signaling|multicellular organism development|negative regulation of cell population proliferation|Wnt signaling pathway|neuron differentiation|negative regulation of chondrocyte differentiation|cell fate commitment|receptor ligand activity|canonical Wnt signaling pathway|iris morphogenesis|cornea development in camera-type eye|cellular response to retinoic acid|embryonic skeletal joint development "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WRAP53 469.200138 486.1639089 452.2363672 0.93021378 -0.104365784 0.805678398 1 8.041308589 7.802349981 55135 WD repeat containing antisense to TP53 "GO:0000781,GO:0003723,GO:0005515,GO:0005654,GO:0005697,GO:0005829,GO:0006281,GO:0007004,GO:0015030,GO:0016032,GO:0016604,GO:0030576,GO:0031625,GO:0032203,GO:0034337,GO:0035861,GO:0042393,GO:0042802,GO:0044877,GO:0045739,GO:0051087,GO:0051973,GO:0070034,GO:0090666,GO:0090671,GO:1904851,GO:1904867,GO:1905168,GO:2000781,GO:2001034" "chromosome, telomeric region|RNA binding|protein binding|nucleoplasm|telomerase holoenzyme complex|cytosol|DNA repair|telomere maintenance via telomerase|Cajal body|viral process|nuclear body|Cajal body organization|ubiquitin protein ligase binding|telomere formation via telomerase|RNA folding|site of double-strand break|histone binding|identical protein binding|protein-containing complex binding|positive regulation of DNA repair|chaperone binding|positive regulation of telomerase activity|telomerase RNA binding|scaRNA localization to Cajal body|telomerase RNA localization to Cajal body|positive regulation of establishment of protein localization to telomere|protein localization to Cajal body|positive regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair|positive regulation of double-strand break repair via nonhomologous end joining" WRAP73 750.0138587 689.1551025 810.8726148 1.176618459 0.234646575 0.529532404 1 20.59190251 25.27249158 49856 "WD repeat containing, antisense to TP73" "GO:0000070,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005815,GO:0030030,GO:0036064,GO:0072686,GO:0090307,GO:1902440,GO:1902857,GO:1990811" mitotic sister chromatid segregation|protein binding|cytoplasm|centrosome|centriole|microtubule organizing center|cell projection organization|ciliary basal body|mitotic spindle|mitotic spindle assembly|protein localization to mitotic spindle pole body|positive regulation of non-motile cilium assembly|MWP complex WRN 516.7088357 399.8926515 633.5250198 1.584237713 0.663788827 0.101903816 1 3.762428398 6.217338615 7486 WRN RecQ like helicase "GO:0000287,GO:0000400,GO:0000403,GO:0000405,GO:0000723,GO:0000724,GO:0000731,GO:0000781,GO:0003677,GO:0003678,GO:0003682,GO:0004386,GO:0004527,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005694,GO:0005730,GO:0005737,GO:0005813,GO:0006259,GO:0006260,GO:0006268,GO:0006281,GO:0006284,GO:0006302,GO:0006310,GO:0006974,GO:0006979,GO:0007420,GO:0007568,GO:0007569,GO:0008408,GO:0009267,GO:0009378,GO:0010225,GO:0010259,GO:0016607,GO:0016887,GO:0030145,GO:0031297,GO:0032405,GO:0032508,GO:0040009,GO:0042803,GO:0042981,GO:0043005,GO:0043138,GO:0044806,GO:0044877,GO:0051345,GO:0051880,GO:0061749,GO:0061820,GO:0061821,GO:0061849,GO:0070337,GO:0071480,GO:0090305,GO:0090399,GO:0090656,GO:0098530,GO:1901796,GO:1902570,GO:1905773" "magnesium ion binding|four-way junction DNA binding|Y-form DNA binding|bubble DNA binding|telomere maintenance|double-strand break repair via homologous recombination|DNA synthesis involved in DNA repair|chromosome, telomeric region|DNA binding|DNA helicase activity|chromatin binding|helicase activity|exonuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|chromosome|nucleolus|cytoplasm|centrosome|DNA metabolic process|DNA replication|DNA unwinding involved in DNA replication|DNA repair|base-excision repair|double-strand break repair|DNA recombination|cellular response to DNA damage stimulus|response to oxidative stress|brain development|aging|cell aging|3'-5' exonuclease activity|cellular response to starvation|four-way junction helicase activity|response to UV-C|multicellular organism aging|nuclear speck|ATPase activity|manganese ion binding|replication fork processing|MutLalpha complex binding|DNA duplex unwinding|regulation of growth rate|protein homodimerization activity|regulation of apoptotic process|neuron projection|3'-5' DNA helicase activity|G-quadruplex DNA unwinding|protein-containing complex binding|positive regulation of hydrolase activity|G-quadruplex DNA binding|forked DNA-dependent helicase activity|telomeric D-loop disassembly|telomeric D-loop binding|telomeric G-quadruplex DNA binding|3'-flap-structured DNA binding|cellular response to gamma radiation|nucleic acid phosphodiester bond hydrolysis|replicative senescence|t-circle formation|positive regulation of strand invasion|regulation of signal transduction by p53 class mediator|protein localization to nucleolus|8-hydroxy-2'-deoxyguanosine DNA binding" WRNIP1 1171.822827 1101.227226 1242.418429 1.128212598 0.174038952 0.613223102 1 13.7237387 16.15025244 56897 WRN helicase interacting protein 1 "GO:0000731,GO:0000781,GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0006261,GO:0006282,GO:0008047,GO:0016020,GO:0016887,GO:0017116,GO:0030174,GO:0032508,GO:0042802,GO:0045087,GO:0046872,GO:0048471,GO:0050790" "DNA synthesis involved in DNA repair|chromosome, telomeric region|DNA binding|protein binding|ATP binding|nucleus|DNA-dependent DNA replication|regulation of DNA repair|enzyme activator activity|membrane|ATPase activity|single-stranded DNA helicase activity|regulation of DNA-dependent DNA replication initiation|DNA duplex unwinding|identical protein binding|innate immune response|metal ion binding|perinuclear region of cytoplasm|regulation of catalytic activity" other WSB1 2991.699246 3263.083438 2720.315054 0.833663958 -0.262462131 0.409523627 1 38.49607843 33.47522047 26118 WD repeat and SOCS box containing 1 "GO:0000209,GO:0005515,GO:0005829,GO:0008150,GO:0035556,GO:0043687" protein polyubiquitination|protein binding|cytosol|biological_process|intracellular signal transduction|post-translational protein modification WSB2 1427.088459 1376.280293 1477.896625 1.073834038 0.102771041 0.759481981 1 23.16508528 25.94699088 55884 WD repeat and SOCS box containing 2 "GO:0005829,GO:0016567,GO:0035556,GO:0043687" cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification WSCD1 3555.559743 4663.722675 2447.396811 0.52477323 -0.930233969 0.0036996 0.21983998 25.18672434 13.78666716 23302 WSC domain containing 1 "GO:0008146,GO:0016021" sulfotransferase activity|integral component of membrane WTAP 1668.680393 1827.935699 1509.425086 0.825753929 -0.276216165 0.399158689 1 23.89122441 20.5780864 9589 WT1 associated protein "GO:0000381,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006397,GO:0007049,GO:0007275,GO:0008380,GO:0016070,GO:0016607,GO:0031965,GO:0036396,GO:0042802,GO:0080009" "regulation of alternative mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA processing|cell cycle|multicellular organism development|RNA splicing|RNA metabolic process|nuclear speck|nuclear membrane|RNA N6-methyladenosine methyltransferase complex|identical protein binding|mRNA methylation" WTIP 281.3778601 241.5595205 321.1961998 1.329677254 0.41107611 0.39549797 1 0.887753976 1.231274245 126374 WT1 interacting protein "GO:0000932,GO:0001666,GO:0003714,GO:0005515,GO:0005634,GO:0005667,GO:0005912,GO:0006355,GO:0007010,GO:0022604,GO:0030030,GO:0035195,GO:0035331,GO:0045892,GO:0046872,GO:2000637" "P-body|response to hypoxia|transcription corepressor activity|protein binding|nucleus|transcription regulator complex|adherens junction|regulation of transcription, DNA-templated|cytoskeleton organization|regulation of cell morphogenesis|cell projection organization|gene silencing by miRNA|negative regulation of hippo signaling|negative regulation of transcription, DNA-templated|metal ion binding|positive regulation of gene silencing by miRNA" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species WWC1 930.7650957 1056.569163 804.9610283 0.761863072 -0.392396366 0.271695724 1 9.887564811 7.857460319 23286 WW and C2 domain containing 1 "GO:0000122,GO:0003713,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007221,GO:0016477,GO:0019900,GO:0030010,GO:0032386,GO:0032587,GO:0032991,GO:0035329,GO:0035330,GO:0035331,GO:0043410,GO:0046621,GO:0048471,GO:0060090" negative regulation of transcription by RNA polymerase II|transcription coactivator activity|protein binding|nucleus|cytoplasm|cytosol|positive regulation of transcription of Notch receptor target|cell migration|kinase binding|establishment of cell polarity|regulation of intracellular transport|ruffle membrane|protein-containing complex|hippo signaling|regulation of hippo signaling|negative regulation of hippo signaling|positive regulation of MAPK cascade|negative regulation of organ growth|perinuclear region of cytoplasm|molecular adaptor activity "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species WWC2 1054.367283 918.5351514 1190.199415 1.295758157 0.373796476 0.284622682 1 6.365704026 8.603721094 80014 WW and C2 domain containing 2 "GO:0000122,GO:0005829,GO:0019900,GO:0035331,GO:0046621,GO:0060090" negative regulation of transcription by RNA polymerase II|cytosol|kinase binding|negative regulation of hippo signaling|negative regulation of organ growth|molecular adaptor activity WWC3 821.4225183 788.6207874 854.2242491 1.083187589 0.115283114 0.754715892 1 5.746059674 6.492167808 55841 WWC family member 3 "GO:0000122,GO:0005829,GO:0019900,GO:0035331,GO:0046621,GO:0060090" negative regulation of transcription by RNA polymerase II|cytosol|kinase binding|negative regulation of hippo signaling|negative regulation of organ growth|molecular adaptor activity WWOX 120.6543131 131.9442759 109.3643502 0.828867713 -0.270786228 0.678114585 1 2.859440352 2.472191986 51741 WW domain containing oxidoreductase "GO:0000122,GO:0001649,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0005886,GO:0005902,GO:0016055,GO:0016491,GO:0019899,GO:0030178,GO:0045944,GO:0048705,GO:0055114,GO:0071560,GO:0072332,GO:0090575,GO:0097191,GO:2001238,GO:2001241" negative regulation of transcription by RNA polymerase II|osteoblast differentiation|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|Golgi apparatus|cytosol|plasma membrane|microvillus|Wnt signaling pathway|oxidoreductase activity|enzyme binding|negative regulation of Wnt signaling pathway|positive regulation of transcription by RNA polymerase II|skeletal system morphogenesis|oxidation-reduction process|cellular response to transforming growth factor beta stimulus|intrinsic apoptotic signaling pathway by p53 class mediator|RNA polymerase II transcription regulator complex|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand WWP1 1431.0889 1380.340117 1481.837682 1.073530838 0.102363634 0.760325005 1 18.13002007 20.30152858 11059 WW domain containing E3 ubiquitin protein ligase 1 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0007417,GO:0016567,GO:0034220,GO:0043161,GO:0045732,GO:0045892,GO:0046718,GO:0061630,GO:0070062" "ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|signal transduction|central nervous system development|protein ubiquitination|ion transmembrane transport|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|viral entry into host cell|ubiquitin protein ligase activity|extracellular exosome" "hsa04120,hsa04144" Ubiquitin mediated proteolysis|Endocytosis WWP2 823.9693108 861.6976171 786.2410044 0.912432608 -0.132210089 0.719415698 1 7.659168905 7.289510642 11060 WW domain containing E3 ubiquitin protein ligase 2 "GO:0000122,GO:0000151,GO:0000209,GO:0001085,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006858,GO:0008134,GO:0010629,GO:0016020,GO:0016567,GO:0032410,GO:0034765,GO:0042391,GO:0043161,GO:0043433,GO:0045732,GO:0045746,GO:0045892,GO:0046718,GO:0051224,GO:0051865,GO:0061630,GO:0070062,GO:0070534,GO:1901016" "negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|protein polyubiquitination|RNA polymerase II transcription factor binding|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|cellular protein modification process|extracellular transport|transcription factor binding|negative regulation of gene expression|membrane|protein ubiquitination|negative regulation of transporter activity|regulation of ion transmembrane transport|regulation of membrane potential|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA-binding transcription factor activity|positive regulation of protein catabolic process|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|viral entry into host cell|negative regulation of protein transport|protein autoubiquitination|ubiquitin protein ligase activity|extracellular exosome|protein K63-linked ubiquitination|regulation of potassium ion transmembrane transporter activity" hsa04120 Ubiquitin mediated proteolysis WWTR1 779.5997528 1263.620181 295.579325 0.233914692 -2.095945618 5.04E-08 2.85E-05 11.0703865 2.701072325 25937 WW domain containing transcription regulator 1 "GO:0000122,GO:0001649,GO:0001894,GO:0001933,GO:0003015,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006367,GO:0006469,GO:0008284,GO:0010718,GO:0016567,GO:0016604,GO:0017145,GO:0031146,GO:0032835,GO:0035264,GO:0035329,GO:0042803,GO:0045599,GO:0045669,GO:0045944,GO:0048762,GO:0060271,GO:0060390,GO:0060993,GO:0072307,GO:0090090,GO:1900182" "negative regulation of transcription by RNA polymerase II|osteoblast differentiation|tissue homeostasis|negative regulation of protein phosphorylation|heart process|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|negative regulation of protein kinase activity|positive regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|protein ubiquitination|nuclear body|stem cell division|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|glomerulus development|multicellular organism growth|hippo signaling|protein homodimerization activity|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|mesenchymal cell differentiation|cilium assembly|regulation of SMAD protein signal transduction|kidney morphogenesis|regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of canonical Wnt signaling pathway|positive regulation of protein localization to nucleus" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species XAB2 1113.398033 1047.434559 1179.361507 1.125952448 0.1711459 0.622092062 1 20.04112781 23.53738098 56949 XPA binding protein 2 "GO:0000349,GO:0000398,GO:0000974,GO:0001824,GO:0005515,GO:0005634,GO:0005654,GO:0006283,GO:0006351,GO:0016020,GO:0021987,GO:0043231,GO:0071007,GO:0071013,GO:0071014" "generation of catalytic spliceosome for first transesterification step|mRNA splicing, via spliceosome|Prp19 complex|blastocyst development|protein binding|nucleus|nucleoplasm|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|membrane|cerebral cortex development|intracellular membrane-bounded organelle|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex" hsa03040 Spliceosome XAF1 28.04762272 31.46363502 24.63161041 0.782859654 -0.353174402 0.750514379 1 0.32192366 0.262877089 54739 XIAP associated factor 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0006915,GO:0008270,GO:0035456,GO:0060337" protein binding|nucleoplasm|mitochondrion|cytosol|apoptotic process|zinc ion binding|response to interferon-beta|type I interferon signaling pathway XBP1 2399.654547 2225.798439 2573.510656 1.156219095 0.209414804 0.51229656 1 62.0411881 74.82318195 7494 X-box binding protein 1 "GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001525,GO:0001889,GO:0002639,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0006366,GO:0006511,GO:0006633,GO:0006914,GO:0006915,GO:0006955,GO:0006990,GO:0007517,GO:0008284,GO:0010832,GO:0015031,GO:0016021,GO:0030335,GO:0030968,GO:0031670,GO:0032755,GO:0032869,GO:0035356,GO:0035470,GO:0036498,GO:0036500,GO:0042149,GO:0042632,GO:0043066,GO:0045348,GO:0045579,GO:0045582,GO:0045600,GO:0045766,GO:0045944,GO:0046982,GO:0048666,GO:0055089,GO:0055092,GO:0060612,GO:0071222,GO:0071230,GO:0071332,GO:0071333,GO:0071353,GO:0071375,GO:1900100,GO:1900103,GO:1902236,GO:1903489,GO:1990418,GO:1990837,GO:2000347" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|angiogenesis|liver development|positive regulation of immunoglobulin production|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|transcription by RNA polymerase II|ubiquitin-dependent protein catabolic process|fatty acid biosynthetic process|autophagy|apoptotic process|immune response|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|muscle organ development|positive regulation of cell population proliferation|negative regulation of myotube differentiation|protein transport|integral component of membrane|positive regulation of cell migration|endoplasmic reticulum unfolded protein response|cellular response to nutrient|positive regulation of interleukin-6 production|cellular response to insulin stimulus|cellular triglyceride homeostasis|positive regulation of vascular wound healing|IRE1-mediated unfolded protein response|ATF6-mediated unfolded protein response|cellular response to glucose starvation|cholesterol homeostasis|negative regulation of apoptotic process|positive regulation of MHC class II biosynthetic process|positive regulation of B cell differentiation|positive regulation of T cell differentiation|positive regulation of fat cell differentiation|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|neuron development|fatty acid homeostasis|sterol homeostasis|adipose tissue development|cellular response to lipopolysaccharide|cellular response to amino acid stimulus|cellular response to fructose stimulus|cellular response to glucose stimulus|cellular response to interleukin-4|cellular response to peptide hormone stimulus|positive regulation of plasma cell differentiation|positive regulation of endoplasmic reticulum unfolded protein response|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of lactation|response to insulin-like growth factor stimulus|sequence-specific double-stranded DNA binding|positive regulation of hepatocyte proliferation" "hsa04141,hsa04932,hsa05010,hsa05012,hsa05014,hsa05017,hsa05022" Protein processing in endoplasmic reticulum|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases TF_bZIP XDH 166.5554615 171.5275587 161.5833643 0.942025676 -0.086161713 0.890379804 1 1.410041508 1.385512879 7498 xanthine dehydrogenase "GO:0001933,GO:0001937,GO:0004854,GO:0004855,GO:0005506,GO:0005515,GO:0005615,GO:0005777,GO:0005829,GO:0006151,GO:0006195,GO:0006919,GO:0007595,GO:0009055,GO:0009115,GO:0010629,GO:0016529,GO:0022900,GO:0042803,GO:0043546,GO:0045602,GO:0046038,GO:0046055,GO:0050660,GO:0051537,GO:0051898,GO:0070674,GO:0070675,GO:0071949,GO:1900745,GO:1900747,GO:2000379,GO:2001213" "negative regulation of protein phosphorylation|negative regulation of endothelial cell proliferation|xanthine dehydrogenase activity|xanthine oxidase activity|iron ion binding|protein binding|extracellular space|peroxisome|cytosol|xanthine oxidation|purine nucleotide catabolic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|lactation|electron transfer activity|xanthine catabolic process|negative regulation of gene expression|sarcoplasmic reticulum|electron transport chain|protein homodimerization activity|molybdopterin cofactor binding|negative regulation of endothelial cell differentiation|GMP catabolic process|dGMP catabolic process|flavin adenine dinucleotide binding|2 iron, 2 sulfur cluster binding|negative regulation of protein kinase B signaling|hypoxanthine dehydrogenase activity|hypoxanthine oxidase activity|FAD binding|positive regulation of p38MAPK cascade|negative regulation of vascular endothelial growth factor signaling pathway|positive regulation of reactive oxygen species metabolic process|negative regulation of vasculogenesis" "hsa00230,hsa00232,hsa00983,hsa04146" Purine metabolism|Caffeine metabolism|Drug metabolism - other enzymes|Peroxisome XIAP 1933.92164 1875.63863 1992.20465 1.062147377 0.086983959 0.788876433 1 10.82311493 11.99093312 331 X-linked inhibitor of apoptosis "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005876,GO:0006974,GO:0016055,GO:0016567,GO:0030510,GO:0031398,GO:0042127,GO:0042802,GO:0043027,GO:0043066,GO:0043154,GO:0045088,GO:0046872,GO:0050727,GO:0051402,GO:0051726,GO:0055070,GO:0061630,GO:0070424,GO:0090263,GO:1902530" ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|spindle microtubule|cellular response to DNA damage stimulus|Wnt signaling pathway|protein ubiquitination|regulation of BMP signaling pathway|positive regulation of protein ubiquitination|regulation of cell population proliferation|identical protein binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of innate immune response|metal ion binding|regulation of inflammatory response|neuron apoptotic process|regulation of cell cycle|copper ion homeostasis|ubiquitin protein ligase activity|regulation of nucleotide-binding oligomerization domain containing signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of protein linear polyubiquitination "hsa01524,hsa04064,hsa04120,hsa04210,hsa04215,hsa04217,hsa04510,hsa04621,hsa05145,hsa05166,hsa05200,hsa05222" Platinum drug resistance|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Apoptosis|Apoptosis - multiple species|Necroptosis|Focal adhesion|NOD-like receptor signaling pathway|Toxoplasmosis|Human T-cell leukemia virus 1 infection|Pathways in cancer|Small cell lung cancer XIRP2 6.060044258 10.14955968 1.970528833 0.194149194 -2.364762376 0.199637567 1 0.039614626 0.008022451 129446 xin actin binding repeat containing 2 "GO:0001725,GO:0005925,GO:0007507,GO:0008150,GO:0030036,GO:0051015" stress fiber|focal adhesion|heart development|biological_process|actin cytoskeleton organization|actin filament binding XKR6 33.61503477 41.6131947 25.61687483 0.615595006 -0.699946568 0.471580782 1 0.268479173 0.172393791 286046 XK related 6 "GO:0005886,GO:0016020,GO:0016021,GO:0043652,GO:0070782,GO:1902742" plasma membrane|membrane|integral component of membrane|engulfment of apoptotic cell|phosphatidylserine exposure on apoptotic cell surface|apoptotic process involved in development XKR8 264.5095988 233.4398727 295.579325 1.266190396 0.340494358 0.491250115 1 4.7538826 6.278608409 55113 XK related 8 "GO:0002513,GO:0005886,GO:0016020,GO:0016021,GO:0043652,GO:0051649,GO:0070782,GO:1902742" tolerance induction to self antigen|plasma membrane|membrane|integral component of membrane|engulfment of apoptotic cell|establishment of localization in cell|phosphatidylserine exposure on apoptotic cell surface|apoptotic process involved in development XKR9 8.015727316 9.134603715 6.896850916 0.755024644 -0.405404361 0.864587159 1 0.093010747 0.073250431 389668 XK related 9 "GO:0005886,GO:0016020,GO:0016021,GO:0043652,GO:0070782,GO:1902742" plasma membrane|membrane|integral component of membrane|engulfment of apoptotic cell|phosphatidylserine exposure on apoptotic cell surface|apoptotic process involved in development XKRX 3.970749218 2.029911937 5.911586499 2.912237912 1.542128219 0.515744462 1 0.019176997 0.058253681 402415 XK related X-linked "GO:0005886,GO:0016021" plasma membrane|integral component of membrane XPA 164.3177087 153.2583512 175.3770661 1.144323065 0.19449441 0.742427972 1 2.822543573 3.369032778 7507 "XPA, DNA damage recognition and repair factor" "GO:0000110,GO:0000715,GO:0000717,GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0005737,GO:0006281,GO:0006283,GO:0006284,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0009650,GO:0010996,GO:0019904,GO:0033683,GO:0034504,GO:0042803,GO:0045171,GO:0046872,GO:0070911,GO:0070914,GO:1901255,GO:1990837" "nucleotide-excision repair factor 1 complex|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|damaged DNA binding|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|cytoplasm|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|UV protection|response to auditory stimulus|protein domain specific binding|nucleotide-excision repair, DNA incision|protein localization to nucleus|protein homodimerization activity|intercellular bridge|metal ion binding|global genome nucleotide-excision repair|UV-damage excision repair|nucleotide-excision repair involved in interstrand cross-link repair|sequence-specific double-stranded DNA binding" "hsa01524,hsa03420" Platinum drug resistance|Nucleotide excision repair XPC 1312.021847 1188.513439 1435.530255 1.207836788 0.27242552 0.419921939 1 15.81971429 19.93071223 7508 "XPC complex subunit, DNA damage recognition and repair factor" "GO:0000109,GO:0000111,GO:0000404,GO:0000405,GO:0000715,GO:0000717,GO:0000720,GO:0003684,GO:0003697,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006281,GO:0006289,GO:0006294,GO:0006298,GO:0010224,GO:0010996,GO:0031573,GO:0042493,GO:0043231,GO:0044877,GO:0045893,GO:0070911,GO:0070914,GO:0071942,GO:0090734,GO:1901990,GO:1990731" "nucleotide-excision repair complex|nucleotide-excision repair factor 2 complex|heteroduplex DNA loop binding|bubble DNA binding|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|pyrimidine dimer repair by nucleotide-excision repair|damaged DNA binding|single-stranded DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|cytosol|plasma membrane|DNA repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|mismatch repair|response to UV-B|response to auditory stimulus|intra-S DNA damage checkpoint|response to drug|intracellular membrane-bounded organelle|protein-containing complex binding|positive regulation of transcription, DNA-templated|global genome nucleotide-excision repair|UV-damage excision repair|XPC complex|site of DNA damage|regulation of mitotic cell cycle phase transition|UV-damage excision repair, DNA incision" hsa03420 Nucleotide excision repair XPNPEP1 990.5099265 1032.21022 948.8096331 0.919201937 -0.121546257 0.732397576 1 17.73933024 17.00842421 7511 X-prolyl aminopeptidase 1 "GO:0004177,GO:0005737,GO:0005829,GO:0006508,GO:0010815,GO:0030145,GO:0042803,GO:0070006,GO:0070062" aminopeptidase activity|cytoplasm|cytosol|proteolysis|bradykinin catabolic process|manganese ion binding|protein homodimerization activity|metalloaminopeptidase activity|extracellular exosome XPNPEP3 642.5930673 653.6316436 631.554491 0.966223862 -0.049570613 0.901454825 1 3.594759135 3.622959544 63929 X-prolyl aminopeptidase 3 "GO:0003094,GO:0004177,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006508,GO:0008233,GO:0016485,GO:0030145,GO:0042803,GO:0070006" glomerular filtration|aminopeptidase activity|protein binding|cytoplasm|mitochondrion|cytosol|proteolysis|peptidase activity|protein processing|manganese ion binding|protein homodimerization activity|metalloaminopeptidase activity XPO1 5216.311499 5410.730267 5021.892731 0.928135849 -0.10759211 0.738385194 1 54.52335856 52.78494547 7514 exportin 1 "GO:0000054,GO:0000055,GO:0000056,GO:0000776,GO:0003723,GO:0005049,GO:0005515,GO:0005634,GO:0005635,GO:0005642,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006611,GO:0006913,GO:0015030,GO:0016020,GO:0016032,GO:0031965,GO:0032434,GO:0032991,GO:0042254,GO:0043231,GO:0043488,GO:0043657,GO:0051028,GO:0075733,GO:1990904" ribosomal subunit export from nucleus|ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|kinetochore|RNA binding|nuclear export signal receptor activity|protein binding|nucleus|nuclear envelope|annulate lamellae|nucleoplasm|nucleolus|cytoplasm|cytosol|protein export from nucleus|nucleocytoplasmic transport|Cajal body|membrane|viral process|nuclear membrane|regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|ribosome biogenesis|intracellular membrane-bounded organelle|regulation of mRNA stability|host cell|mRNA transport|intracellular transport of virus|ribonucleoprotein complex "hsa03008,hsa03013,hsa05164,hsa05166" Ribosome biogenesis in eukaryotes|RNA transport|Influenza A|Human T-cell leukemia virus 1 infection XPO4 851.6160975 865.757441 837.4747541 0.967331858 -0.047917182 0.898064022 1 2.933535839 2.959939396 64328 exportin 4 "GO:0005049,GO:0005515,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006611,GO:0046827" nuclear export signal receptor activity|protein binding|nuclear pore|nucleoplasm|cytoplasm|cytosol|protein export from nucleus|positive regulation of protein export from nucleus XPO5 1439.616064 1525.47882 1353.753308 0.887428452 -0.172297286 0.605956294 1 14.51439427 13.43532556 57510 exportin 5 "GO:0000049,GO:0003723,GO:0003729,GO:0005049,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006611,GO:0010586,GO:0016032,GO:0016442,GO:0031267,GO:0035281,GO:0042565,GO:0070883,GO:1900370,GO:1905172" tRNA binding|RNA binding|mRNA binding|nuclear export signal receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|protein export from nucleus|miRNA metabolic process|viral process|RISC complex|small GTPase binding|pre-miRNA export from nucleus|RNA nuclear export complex|pre-miRNA binding|positive regulation of RNA interference|RISC complex binding hsa03013 RNA transport XPO6 2510.322358 2719.067039 2301.577677 0.846458599 -0.240488588 0.451124837 1 22.79608562 20.12713366 23214 exportin 6 "GO:0005049,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006611,GO:0032991" nuclear export signal receptor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|protein export from nucleus|protein-containing complex XPO7 2568.490815 2620.61631 2516.36532 0.960218903 -0.058564757 0.855293566 1 27.2535875 27.29668195 23039 exportin 7 "GO:0005049,GO:0005515,GO:0005634,GO:0005643,GO:0005737,GO:0006611" nuclear export signal receptor activity|protein binding|nucleus|nuclear pore|cytoplasm|protein export from nucleus XPOT 3821.919121 3811.159661 3832.67858 1.005646292 0.008122966 0.980559343 1 28.97355027 30.39225335 11260 exportin for tRNA "GO:0000049,GO:0005515,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006409,GO:0016363,GO:0071528" tRNA binding|protein binding|nuclear pore|nucleoplasm|cytoplasm|cytosol|tRNA export from nucleus|nuclear matrix|tRNA re-export from nucleus hsa03013 RNA transport XPR1 1258.478591 1502.134833 1014.822349 0.675586723 -0.56578712 0.096078009 1 7.151516271 5.039589549 9213 xenotropic and polytropic retrovirus receptor 1 "GO:0000822,GO:0001618,GO:0004888,GO:0004930,GO:0005737,GO:0005794,GO:0005886,GO:0006817,GO:0007186,GO:0009615,GO:0015114,GO:0015562,GO:0016021,GO:0016036,GO:0030643,GO:0031226,GO:0035435,GO:0038023,GO:0046718" inositol hexakisphosphate binding|virus receptor activity|transmembrane signaling receptor activity|G protein-coupled receptor activity|cytoplasm|Golgi apparatus|plasma membrane|phosphate ion transport|G protein-coupled receptor signaling pathway|response to virus|phosphate ion transmembrane transporter activity|efflux transmembrane transporter activity|integral component of membrane|cellular response to phosphate starvation|cellular phosphate ion homeostasis|intrinsic component of plasma membrane|phosphate ion transmembrane transport|signaling receptor activity|viral entry into host cell XRCC1 1017.998853 958.1184341 1077.879272 1.12499586 0.169919692 0.629867974 1 23.64781611 27.74967451 7515 X-ray repair cross complementing 1 "GO:0000012,GO:0000724,GO:0000781,GO:0000785,GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006283,GO:0006284,GO:0006288,GO:0006297,GO:0006303,GO:0010033,GO:0010836,GO:0019899,GO:0021587,GO:0021766,GO:0032356,GO:0033194,GO:0042493,GO:0050882,GO:0061819,GO:0070522,GO:1903518,GO:1904877,GO:1905765,GO:1990414,GO:1990599" "single strand break repair|double-strand break repair via homologous recombination|chromosome, telomeric region|chromatin|response to hypoxia|protein binding|nucleus|nucleoplasm|nucleolus|transcription-coupled nucleotide-excision repair|base-excision repair|base-excision repair, DNA ligation|nucleotide-excision repair, DNA gap filling|double-strand break repair via nonhomologous end joining|response to organic substance|negative regulation of protein ADP-ribosylation|enzyme binding|cerebellum morphogenesis|hippocampus development|oxidized DNA binding|response to hydroperoxide|response to drug|voluntary musculoskeletal movement|telomeric DNA-containing double minutes formation|ERCC4-ERCC1 complex|positive regulation of single strand break repair|positive regulation of DNA ligase activity|negative regulation of protection from non-homologous end joining at telomere|replication-born double-strand break repair via sister chromatid exchange|3' overhang single-stranded DNA endodeoxyribonuclease activity" hsa03410 Base excision repair XRCC2 538.5101 509.5078961 567.5123039 1.113843982 0.155547166 0.701012681 1 5.408672711 6.283925025 7516 X-ray repair cross complementing 2 "GO:0000278,GO:0000400,GO:0000724,GO:0001701,GO:0001756,GO:0005515,GO:0005524,GO:0005654,GO:0005657,GO:0005737,GO:0005813,GO:0006281,GO:0007098,GO:0008094,GO:0010165,GO:0010332,GO:0033063,GO:0035264,GO:0042148,GO:0043231,GO:0043524,GO:0050769,GO:0051321,GO:2000269" mitotic cell cycle|four-way junction DNA binding|double-strand break repair via homologous recombination|in utero embryonic development|somitogenesis|protein binding|ATP binding|nucleoplasm|replication fork|cytoplasm|centrosome|DNA repair|centrosome cycle|DNA-dependent ATPase activity|response to X-ray|response to gamma radiation|Rad51B-Rad51C-Rad51D-XRCC2 complex|multicellular organism growth|strand invasion|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|positive regulation of neurogenesis|meiotic cell cycle|regulation of fibroblast apoptotic process hsa03440 Homologous recombination XRCC3 732.1779003 648.5568638 815.7989369 1.257868018 0.330980555 0.376738161 1 12.58510237 16.51230711 7517 X-ray repair cross complementing 3 "GO:0000400,GO:0000722,GO:0000724,GO:0000781,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005739,GO:0005829,GO:0006281,GO:0006310,GO:0006974,GO:0008094,GO:0008821,GO:0010033,GO:0010824,GO:0033065,GO:0036297,GO:0045003,GO:0048471,GO:0071140,GO:0090267,GO:0090656,GO:0090657,GO:0090737" "four-way junction DNA binding|telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, telomeric region|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|cytoplasm|mitochondrion|cytosol|DNA repair|DNA recombination|cellular response to DNA damage stimulus|DNA-dependent ATPase activity|crossover junction endodeoxyribonuclease activity|response to organic substance|regulation of centrosome duplication|Rad51C-XRCC3 complex|interstrand cross-link repair|double-strand break repair via synthesis-dependent strand annealing|perinuclear region of cytoplasm|resolution of mitotic recombination intermediates|positive regulation of mitotic cell cycle spindle assembly checkpoint|t-circle formation|telomeric loop disassembly|telomere maintenance via telomere trimming" hsa03440 Homologous recombination XRCC4 183.9433249 215.1706653 152.7159846 0.709743516 -0.494630331 0.373165817 1 3.234679466 2.39468622 7518 X-ray repair cross complementing 4 "GO:0000793,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005958,GO:0006302,GO:0006303,GO:0008022,GO:0010165,GO:0016874,GO:0032807,GO:0033152,GO:0035861,GO:0042802,GO:0051103,GO:0051351,GO:0070419,GO:0071285,GO:0075713,GO:1990166" condensed chromosome|DNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA-dependent protein kinase-DNA ligase 4 complex|double-strand break repair|double-strand break repair via nonhomologous end joining|protein C-terminus binding|response to X-ray|ligase activity|DNA ligase IV complex|immunoglobulin V(D)J recombination|site of double-strand break|identical protein binding|DNA ligation involved in DNA repair|positive regulation of ligase activity|nonhomologous end joining complex|cellular response to lithium ion|establishment of integrated proviral latency|protein localization to site of double-strand break hsa03450 Non-homologous end-joining other XRCC5 7175.045621 7265.054822 7085.036419 0.975221329 -0.036198415 0.912522591 1 108.8929852 110.7692015 7520 X-ray repair cross complementing 5 "GO:0000723,GO:0000781,GO:0000783,GO:0000976,GO:0002218,GO:0003677,GO:0003678,GO:0003684,GO:0003690,GO:0003691,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006302,GO:0006303,GO:0006310,GO:0006974,GO:0007420,GO:0008022,GO:0008047,GO:0008094,GO:0008283,GO:0016020,GO:0031625,GO:0032040,GO:0032204,GO:0032212,GO:0032481,GO:0032508,GO:0032991,GO:0032993,GO:0034462,GO:0034511,GO:0034774,GO:0042162,GO:0042493,GO:0043085,GO:0043312,GO:0043564,GO:0044877,GO:0045027,GO:0045087,GO:0045860,GO:0045892,GO:0048660,GO:0050769,GO:0051575,GO:0051973,GO:0060218,GO:0070198,GO:0070419,GO:0071398,GO:0071475,GO:0071480,GO:0071481,GO:0075713,GO:0090734,GO:1904430,GO:1990830,GO:1990904" "telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|transcription regulatory region sequence-specific DNA binding|activation of innate immune response|DNA binding|DNA helicase activity|damaged DNA binding|double-stranded DNA binding|double-stranded telomeric DNA binding|RNA binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|double-strand break repair|double-strand break repair via nonhomologous end joining|DNA recombination|cellular response to DNA damage stimulus|brain development|protein C-terminus binding|enzyme activator activity|DNA-dependent ATPase activity|cell population proliferation|membrane|ubiquitin protein ligase binding|small-subunit processome|regulation of telomere maintenance|positive regulation of telomere maintenance via telomerase|positive regulation of type I interferon production|DNA duplex unwinding|protein-containing complex|protein-DNA complex|small-subunit processome assembly|U3 snoRNA binding|secretory granule lumen|telomeric DNA binding|response to drug|positive regulation of catalytic activity|neutrophil degranulation|Ku70:Ku80 complex|protein-containing complex binding|DNA end binding|innate immune response|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|regulation of smooth muscle cell proliferation|positive regulation of neurogenesis|5'-deoxyribose-5-phosphate lyase activity|positive regulation of telomerase activity|hematopoietic stem cell differentiation|protein localization to chromosome, telomeric region|nonhomologous end joining complex|cellular response to fatty acid|cellular hyperosmotic salinity response|cellular response to gamma radiation|cellular response to X-ray|establishment of integrated proviral latency|site of DNA damage|negative regulation of t-circle formation|cellular response to leukemia inhibitory factor|ribonucleoprotein complex" hsa03450 Non-homologous end-joining XRCC6 9756.444588 10128.24561 9384.643568 0.926581358 -0.110010438 0.743292379 1 241.7341705 233.6348006 2547 X-ray repair cross complementing 6 "GO:0000723,GO:0000781,GO:0000783,GO:0000976,GO:0002218,GO:0003677,GO:0003678,GO:0003684,GO:0003690,GO:0003691,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0006266,GO:0006303,GO:0006310,GO:0007420,GO:0008022,GO:0008094,GO:0016020,GO:0030332,GO:0032481,GO:0032508,GO:0032991,GO:0032993,GO:0034774,GO:0042162,GO:0043312,GO:0043564,GO:0044877,GO:0045027,GO:0045087,GO:0045621,GO:0045860,GO:0045892,GO:0045893,GO:0045944,GO:0048660,GO:0051575,GO:0070419,GO:0071475,GO:0071480,GO:0071481,GO:0075713,GO:0097680,GO:1904813" "telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|transcription regulatory region sequence-specific DNA binding|activation of innate immune response|DNA binding|DNA helicase activity|damaged DNA binding|double-stranded DNA binding|double-stranded telomeric DNA binding|RNA binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytosol|DNA ligation|double-strand break repair via nonhomologous end joining|DNA recombination|brain development|protein C-terminus binding|DNA-dependent ATPase activity|membrane|cyclin binding|positive regulation of type I interferon production|DNA duplex unwinding|protein-containing complex|protein-DNA complex|secretory granule lumen|telomeric DNA binding|neutrophil degranulation|Ku70:Ku80 complex|protein-containing complex binding|DNA end binding|innate immune response|positive regulation of lymphocyte differentiation|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of smooth muscle cell proliferation|5'-deoxyribose-5-phosphate lyase activity|nonhomologous end joining complex|cellular hyperosmotic salinity response|cellular response to gamma radiation|cellular response to X-ray|establishment of integrated proviral latency|double-strand break repair via classical nonhomologous end joining|ficolin-1-rich granule lumen" hsa03450 Non-homologous end-joining XRN1 888.551389 831.2489381 945.8538399 1.137870735 0.186336673 0.606012331 1 3.908990366 4.639524342 54464 5'-3' exoribonuclease 1 "GO:0000932,GO:0000956,GO:0002151,GO:0003723,GO:0004534,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0016020,GO:0016075,GO:0017148,GO:0030425,GO:0032211,GO:0033574,GO:0043025,GO:0043488,GO:0045202,GO:0051880,GO:0070034,GO:0071028,GO:0071044,GO:0071409,GO:0090503,GO:1905795" "P-body|nuclear-transcribed mRNA catabolic process|G-quadruplex RNA binding|RNA binding|5'-3' exoribonuclease activity|protein binding|nucleus|cytosol|plasma membrane|membrane|rRNA catabolic process|negative regulation of translation|dendrite|negative regulation of telomere maintenance via telomerase|response to testosterone|neuronal cell body|regulation of mRNA stability|synapse|G-quadruplex DNA binding|telomerase RNA binding|nuclear mRNA surveillance|histone mRNA catabolic process|cellular response to cycloheximide|RNA phosphodiester bond hydrolysis, exonucleolytic|cellular response to puromycin" "hsa03008,hsa03018" Ribosome biogenesis in eukaryotes|RNA degradation XRN2 5145.915074 5346.788041 4945.042107 0.924862192 -0.112689681 0.726273403 1 62.20904019 60.01315464 22803 5'-3' exoribonuclease 2 "GO:0000175,GO:0000738,GO:0000956,GO:0001147,GO:0003723,GO:0004518,GO:0004534,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006353,GO:0006364,GO:0006396,GO:0006397,GO:0006401,GO:0007283,GO:0008409,GO:0016020,GO:0016070,GO:0016235,GO:0021766,GO:0030182,GO:0042802,GO:0046872,GO:0060041,GO:0090503" "3'-5'-exoribonuclease activity|DNA catabolic process, exonucleolytic|nuclear-transcribed mRNA catabolic process|transcription termination site sequence-specific DNA binding|RNA binding|nuclease activity|5'-3' exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA-templated transcription, termination|rRNA processing|RNA processing|mRNA processing|RNA catabolic process|spermatogenesis|5'-3' exonuclease activity|membrane|RNA metabolic process|aggresome|hippocampus development|neuron differentiation|identical protein binding|metal ion binding|retina development in camera-type eye|RNA phosphodiester bond hydrolysis, exonucleolytic" "hsa03008,hsa03018" Ribosome biogenesis in eukaryotes|RNA degradation other XRRA1 194.377676 221.2604011 167.4949508 0.757003738 -0.40162767 0.462557037 1 2.062591341 1.628647677 143570 X-ray radiation resistance associated 1 "GO:0003674,GO:0005634,GO:0005654,GO:0005737,GO:0010165,GO:0016604" molecular_function|nucleus|nucleoplasm|cytoplasm|response to X-ray|nuclear body XXYLT1 630.5390429 738.887945 522.1901408 0.706724402 -0.500780372 0.195274018 1 3.095034966 2.28155833 152002 xyloside xylosyltransferase 1 "GO:0000287,GO:0016266,GO:0030145,GO:0030176,GO:0035252,GO:0140560" "magnesium ion binding|O-glycan processing|manganese ion binding|integral component of endoplasmic reticulum membrane|UDP-xylosyltransferase activity|xylosyl alpha-1,3-xylosyltransferase activity" hsa00514 Other types of O-glycan biosynthesis XYLB 180.9429944 212.1257974 149.7601913 0.705997069 -0.5022659 0.36838262 1 0.909380676 0.669675714 9942 xylulokinase "GO:0004856,GO:0005524,GO:0005829,GO:0005975,GO:0005997,GO:0005998,GO:0006091,GO:0016310,GO:0016773,GO:0019640,GO:0042732,GO:0046835" "xylulokinase activity|ATP binding|cytosol|carbohydrate metabolic process|xylulose metabolic process|xylulose catabolic process|generation of precursor metabolites and energy|phosphorylation|phosphotransferase activity, alcohol group as acceptor|glucuronate catabolic process to xylulose 5-phosphate|D-xylose metabolic process|carbohydrate phosphorylation" hsa00040 Pentose and glucuronate interconversions XYLT2 1148.939059 1086.002886 1211.875232 1.115904246 0.158213238 0.647134263 1 15.71042988 18.28651424 64132 xylosyltransferase 2 "GO:0000139,GO:0000287,GO:0005615,GO:0006024,GO:0015012,GO:0016021,GO:0018215,GO:0030145,GO:0030158,GO:0030203,GO:0030206,GO:0030210,GO:0050650" Golgi membrane|magnesium ion binding|extracellular space|glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|protein phosphopantetheinylation|manganese ion binding|protein xylosyltransferase activity|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|heparin biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process "hsa00532,hsa00534" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin YAE1 140.8346662 164.4228669 117.2464656 0.71307883 -0.487866521 0.422130784 1 2.490262607 1.852245808 57002 YAE1 maturation factor of ABCE1 "GO:0005515,GO:0005634,GO:0005737,GO:0106035" protein binding|nucleus|cytoplasm|protein maturation by [4Fe-4S] cluster transfer YAF2 231.1145291 240.5445645 221.6844937 0.921594276 -0.117796339 0.825895522 1 1.294795791 1.244677897 10138 YY1 associated factor 2 "GO:0003677,GO:0003712,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0045892,GO:0045893,GO:0046872,GO:0070317" "DNA binding|transcription coregulator activity|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of G0 to G1 transition" YAP1 3843.481615 3736.05292 3950.91031 1.057509194 0.080670206 0.800595362 1 30.55844644 33.7078733 10413 Yes1 associated transcriptional regulator "GO:0000122,GO:0000902,GO:0000976,GO:0000978,GO:0001570,GO:0001674,GO:0001829,GO:0001894,GO:0003015,GO:0003143,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006367,GO:0006974,GO:0008022,GO:0008283,GO:0010628,GO:0010629,GO:0010837,GO:0016020,GO:0030216,GO:0030857,GO:0030903,GO:0032570,GO:0033148,GO:0035019,GO:0035329,GO:0042060,GO:0045599,GO:0045669,GO:0045747,GO:0045893,GO:0045944,GO:0048339,GO:0048368,GO:0050679,GO:0050767,GO:0050847,GO:0060045,GO:0060242,GO:0060449,GO:0060487,GO:0060576,GO:0061026,GO:0065003,GO:0070064,GO:0070102,GO:0071300,GO:0071480,GO:0072091,GO:0072307,GO:0090263,GO:0140297,GO:0140552,GO:1900182,GO:1902018,GO:1902036,GO:1902459,GO:1904036,GO:2000737,GO:2001237" "negative regulation of transcription by RNA polymerase II|cell morphogenesis|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|vasculogenesis|female germ cell nucleus|trophectodermal cell differentiation|tissue homeostasis|heart process|embryonic heart tube morphogenesis|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription initiation from RNA polymerase II promoter|cellular response to DNA damage stimulus|protein C-terminus binding|cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|regulation of keratinocyte proliferation|membrane|keratinocyte differentiation|negative regulation of epithelial cell differentiation|notochord development|response to progesterone|positive regulation of intracellular estrogen receptor signaling pathway|somatic stem cell population maintenance|hippo signaling|wound healing|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|paraxial mesoderm development|lateral mesoderm development|positive regulation of epithelial cell proliferation|regulation of neurogenesis|progesterone receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|contact inhibition|bud elongation involved in lung branching|lung epithelial cell differentiation|intestinal epithelial cell development|cardiac muscle tissue regeneration|protein-containing complex assembly|proline-rich region binding|interleukin-6-mediated signaling pathway|cellular response to retinoic acid|cellular response to gamma radiation|regulation of stem cell proliferation|regulation of metanephric nephron tubule epithelial cell differentiation|positive regulation of canonical Wnt signaling pathway|DNA-binding transcription factor binding|TEAD-YAP complex|positive regulation of protein localization to nucleus|negative regulation of cilium assembly|regulation of hematopoietic stem cell differentiation|positive regulation of stem cell population maintenance|negative regulation of epithelial cell apoptotic process|negative regulation of stem cell differentiation|negative regulation of extrinsic apoptotic signaling pathway" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species other YARS1 1746.768906 1474.731022 2018.80679 1.368932205 0.453051 0.16482153 1 29.98391157 42.8140349 8565 tyrosyl-tRNA synthetase 1 "GO:0000049,GO:0003723,GO:0004831,GO:0005153,GO:0005515,GO:0005524,GO:0005615,GO:0005737,GO:0005829,GO:0006418,GO:0006437,GO:0006915,GO:0016604" tRNA binding|RNA binding|tyrosine-tRNA ligase activity|interleukin-8 receptor binding|protein binding|ATP binding|extracellular space|cytoplasm|cytosol|tRNA aminoacylation for protein translation|tyrosyl-tRNA aminoacylation|apoptotic process|nuclear body hsa00970 Aminoacyl-tRNA biosynthesis YARS2 762.8262555 824.1442463 701.5082646 0.851195974 -0.232436767 0.531954337 1 19.71657944 17.50560253 51067 tyrosyl-tRNA synthetase 2 "GO:0000049,GO:0003723,GO:0004831,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006412,GO:0006418,GO:0016604,GO:0042803,GO:0043039,GO:0070184,GO:0072545" tRNA binding|RNA binding|tyrosine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|translation|tRNA aminoacylation for protein translation|nuclear body|protein homodimerization activity|tRNA aminoacylation|mitochondrial tyrosyl-tRNA aminoacylation|tyrosine binding hsa00970 Aminoacyl-tRNA biosynthesis YBEY 172.7936551 193.85659 151.7307201 0.782695704 -0.353476569 0.535280791 1 1.683208023 1.374189647 54059 ybeY metalloendoribonuclease "GO:0004222,GO:0004521,GO:0005634,GO:0006364,GO:0006508,GO:0046872,GO:0090502" "metalloendopeptidase activity|endoribonuclease activity|nucleus|rRNA processing|proteolysis|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" YBX1 16627.04078 17426.79398 15827.28759 0.908215683 -0.138893146 0.695477814 1 296.2758096 280.6733125 4904 Y-box binding protein 1 "GO:0000398,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005689,GO:0005737,GO:0005829,GO:0006355,GO:0007219,GO:0008544,GO:0010468,GO:0010494,GO:0017148,GO:0031965,GO:0035198,GO:0043231,GO:0045944,GO:0048255,GO:0048598,GO:0050658,GO:0051020,GO:0051031,GO:0051781,GO:0062153,GO:0070062,GO:0070934,GO:0070937,GO:0071204,GO:1903608,GO:1990124,GO:1990428,GO:1990837,GO:1990904,GO:2000773" "mRNA splicing, via spliceosome|nucleic acid binding|DNA binding|double-stranded DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|U12-type spliceosomal complex|cytoplasm|cytosol|regulation of transcription, DNA-templated|Notch signaling pathway|epidermis development|regulation of gene expression|cytoplasmic stress granule|negative regulation of translation|nuclear membrane|miRNA binding|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|mRNA stabilization|embryonic morphogenesis|RNA transport|GTPase binding|tRNA transport|positive regulation of cell division|C5-methylcytidine-containing RNA binding|extracellular exosome|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|histone pre-mRNA 3'end processing complex|protein localization to cytoplasmic stress granule|messenger ribonucleoprotein complex|miRNA transport|sequence-specific double-stranded DNA binding|ribonucleoprotein complex|negative regulation of cellular senescence" YBX3 3156.897307 2870.295479 3443.499136 1.199701969 0.262676054 0.409013992 1 58.31140802 72.96974515 8531 Y-box binding protein 3 "GO:0000122,GO:0000977,GO:0001227,GO:0001701,GO:0003676,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005923,GO:0007283,GO:0008584,GO:0009566,GO:0010468,GO:0031267,GO:0046622,GO:0048471,GO:0048642,GO:0060546,GO:0070935,GO:0071356,GO:0071474,GO:1902219,GO:1905538,GO:2000767" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|in utero embryonic development|nucleic acid binding|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|bicellular tight junction|spermatogenesis|male gonad development|fertilization|regulation of gene expression|small GTPase binding|positive regulation of organ growth|perinuclear region of cytoplasm|negative regulation of skeletal muscle tissue development|negative regulation of necroptotic process|3'-UTR-mediated mRNA stabilization|cellular response to tumor necrosis factor|cellular hyperosmotic response|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|polysome binding|positive regulation of cytoplasmic translation" hsa04530 Tight junction YDJC 393.8328534 419.1768149 368.4888918 0.879077465 -0.185937793 0.672724265 1 16.21835516 14.87133249 150223 YdjC chitooligosaccharide deacetylase homolog "GO:0000287,GO:0005975,GO:0019213" magnesium ion binding|carbohydrate metabolic process|deacetylase activity YEATS2 3448.948042 3673.12565 3224.770435 0.877936325 -0.187811787 0.555123202 1 25.16991694 23.04945871 55689 YEATS domain containing 2 "GO:0000122,GO:0005515,GO:0005671,GO:0017025,GO:0042393,GO:0043966,GO:0045892,GO:0072686,GO:0140030" "negative regulation of transcription by RNA polymerase II|protein binding|Ada2/Gcn5/Ada3 transcription activator complex|TBP-class protein binding|histone binding|histone H3 acetylation|negative regulation of transcription, DNA-templated|mitotic spindle|modification-dependent protein binding" YEATS4 299.3622762 292.3073189 306.4172335 1.048270822 0.068011487 0.892524402 1 10.08469653 11.02687017 8089 YEATS domain containing 4 "GO:0000278,GO:0005200,GO:0005515,GO:0005634,GO:0005654,GO:0007010,GO:0008022,GO:0016363,GO:0031965,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0045893,GO:0045944,GO:0070577,GO:0140030" "mitotic cell cycle|structural constituent of cytoskeleton|protein binding|nucleus|nucleoplasm|cytoskeleton organization|protein C-terminus binding|nuclear matrix|nuclear membrane|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lysine-acetylated histone binding|modification-dependent protein binding" YES1 1928.166676 1785.307548 2071.025804 1.160038675 0.214172905 0.507804511 1 17.89776903 21.65645153 7525 "YES proto-oncogene 1, Src family tyrosine kinase" "GO:0001784,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0005925,GO:0006464,GO:0007169,GO:0019899,GO:0030154,GO:0031234,GO:0031295,GO:0038083,GO:0038096,GO:0042127,GO:0043114,GO:0044325,GO:0045087,GO:0048013,GO:0050900,GO:0070062" phosphotyrosine residue binding|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|focal adhesion|cellular protein modification process|transmembrane receptor protein tyrosine kinase signaling pathway|enzyme binding|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell population proliferation|regulation of vascular permeability|ion channel binding|innate immune response|ephrin receptor signaling pathway|leukocyte migration|extracellular exosome hsa04520 Adherens junction YIF1A 1281.628346 1367.145689 1196.111002 0.874896517 -0.19281571 0.569902561 1 63.11860179 57.60099521 10897 "Yip1 interacting factor homolog A, membrane trafficking protein" "GO:0005515,GO:0005789,GO:0005793,GO:0005794,GO:0006888,GO:0015031,GO:0030134,GO:0030173,GO:0033116,GO:0036498,GO:0043231" protein binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|IRE1-mediated unfolded protein response|intracellular membrane-bounded organelle YIF1B 843.3101357 937.8193148 748.8009566 0.798449067 -0.324727714 0.372100064 1 14.38003023 11.97630773 90522 "Yip1 interacting factor homolog B, membrane trafficking protein" "GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006612,GO:0006888,GO:0030134,GO:0030173,GO:0033116" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|protein targeting to membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|endoplasmic reticulum-Golgi intermediate compartment membrane YIPF1 349.3084027 338.9952934 359.621512 1.060845147 0.08521408 0.855898378 1 9.428289791 10.43279915 54432 Yip1 domain family member 1 "GO:0000138,GO:0005515,GO:0005654,GO:0005794,GO:0005797,GO:0005802,GO:0005886,GO:0016021,GO:0016192,GO:0030133,GO:0031902" Golgi trans cisterna|protein binding|nucleoplasm|Golgi apparatus|Golgi medial cisterna|trans-Golgi network|plasma membrane|integral component of membrane|vesicle-mediated transport|transport vesicle|late endosome membrane YIPF2 955.2564132 945.9389625 964.5738638 1.019699898 0.028144624 0.939918912 1 22.60900018 24.04748503 78992 Yip1 domain family member 2 "GO:0000138,GO:0005515,GO:0005794,GO:0005797,GO:0005802,GO:0016021,GO:0016192,GO:0030133,GO:0031902" Golgi trans cisterna|protein binding|Golgi apparatus|Golgi medial cisterna|trans-Golgi network|integral component of membrane|vesicle-mediated transport|transport vesicle|late endosome membrane YIPF3 1411.561761 1392.519589 1430.603933 1.027349234 0.038926691 0.909323834 1 46.79907409 50.15004094 25844 Yip1 domain family member 3 "GO:0005515,GO:0005794,GO:0005886,GO:0016021,GO:0030133,GO:0030154,GO:0043231" protein binding|Golgi apparatus|plasma membrane|integral component of membrane|transport vesicle|cell differentiation|intracellular membrane-bounded organelle YIPF4 492.5401659 397.8627396 587.2175923 1.475930098 0.561624395 0.171199562 1 8.319712711 12.80825746 84272 Yip1 domain family member 4 "GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0016021,GO:0016032,GO:0043231" protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of membrane|viral process|intracellular membrane-bounded organelle YIPF5 1763.666613 1855.33951 1671.993715 0.901179383 -0.150113787 0.64558106 1 27.67787951 26.01716622 81555 Yip1 domain family member 5 "GO:0005515,GO:0005654,GO:0005783,GO:0005789,GO:0005794,GO:0015031,GO:0016021,GO:0016192,GO:0030134,GO:0043231,GO:0060628,GO:0070971" protein binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein transport|integral component of membrane|vesicle-mediated transport|COPII-coated ER to Golgi transport vesicle|intracellular membrane-bounded organelle|regulation of ER to Golgi vesicle-mediated transport|endoplasmic reticulum exit site YIPF6 1545.401099 1482.85067 1607.951528 1.084365109 0.116850598 0.724708589 1 9.148636282 10.34779525 286451 Yip1 domain family member 6 "GO:0000138,GO:0000139,GO:0005515,GO:0005783,GO:0005797,GO:0005801,GO:0005802,GO:0016021,GO:0030134,GO:0042802,GO:0060576" Golgi trans cisterna|Golgi membrane|protein binding|endoplasmic reticulum|Golgi medial cisterna|cis-Golgi network|trans-Golgi network|integral component of membrane|COPII-coated ER to Golgi transport vesicle|identical protein binding|intestinal epithelial cell development YJEFN3 17.97229191 16.23929549 19.70528833 1.213432463 0.279093814 0.851268184 1 0.321651556 0.407115086 374887 YjeF N-terminal domain containing 3 "GO:0002040,GO:0005515,GO:0005739,GO:0006869,GO:0008593,GO:0010874,GO:0016020,GO:0016525,GO:0031580,GO:0052856,GO:0052857,GO:0071425" sprouting angiogenesis|protein binding|mitochondrion|lipid transport|regulation of Notch signaling pathway|regulation of cholesterol efflux|membrane|negative regulation of angiogenesis|membrane raft distribution|NADHX epimerase activity|NADPHX epimerase activity|hematopoietic stem cell proliferation YJU2 309.4348854 341.0252054 277.8445655 0.814733225 -0.295600352 0.530135114 1 12.06968804 10.25716643 55702 YJU2 splicing factor homolog "GO:0000349,GO:0005515,GO:0008380,GO:0043518,GO:0046872,GO:0071006" "generation of catalytic spliceosome for first transesterification step|protein binding|RNA splicing|negative regulation of DNA damage response, signal transduction by p53 class mediator|metal ion binding|U2-type catalytic step 1 spliceosome" YKT6 3173.252401 3314.846193 3031.65861 0.914569918 -0.128834628 0.685880169 1 59.57603463 56.83350434 10652 YKT6 v-SNARE homolog "GO:0000139,GO:0005484,GO:0005737,GO:0005739,GO:0005768,GO:0005783,GO:0005794,GO:0005829,GO:0005887,GO:0006888,GO:0006903,GO:0006904,GO:0015031,GO:0018215,GO:0019706,GO:0030133,GO:0030659,GO:0031201,GO:0033116,GO:0042147,GO:0043025,GO:0045296,GO:0061025,GO:0097440,GO:0097441" "Golgi membrane|SNAP receptor activity|cytoplasm|mitochondrion|endosome|endoplasmic reticulum|Golgi apparatus|cytosol|integral component of plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|vesicle targeting|vesicle docking involved in exocytosis|protein transport|protein phosphopantetheinylation|protein-cysteine S-palmitoyltransferase activity|transport vesicle|cytoplasmic vesicle membrane|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|retrograde transport, endosome to Golgi|neuronal cell body|cadherin binding|membrane fusion|apical dendrite|basal dendrite" hsa04130 SNARE interactions in vesicular transport YLPM1 2051.139652 2042.091408 2060.187895 1.008861742 0.012728476 0.970092987 1 12.63897419 13.30023791 56252 YLP motif containing 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0008150,GO:0016607,GO:0032204" RNA binding|protein binding|nucleus|nucleoplasm|cytosol|biological_process|nuclear speck|regulation of telomere maintenance YME1L1 4258.666154 4469.866085 4047.466223 0.905500556 -0.143212568 0.653946815 1 45.01549979 42.51740277 10730 YME1 like 1 ATPase "GO:0004176,GO:0004222,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0006508,GO:0006515,GO:0006851,GO:0007005,GO:0008283,GO:0016020,GO:0016021,GO:0016604,GO:0034214,GO:0034982,GO:0035694,GO:0043066,GO:0046872" ATP-dependent peptidase activity|metalloendopeptidase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|proteolysis|protein quality control for misfolded or incompletely synthesized proteins|mitochondrial calcium ion transmembrane transport|mitochondrion organization|cell population proliferation|membrane|integral component of membrane|nuclear body|protein hexamerization|mitochondrial protein processing|mitochondrial protein catabolic process|negative regulation of apoptotic process|metal ion binding YOD1 421.8562277 381.6234441 462.0890114 1.210850692 0.27602098 0.519984381 1 2.847360218 3.596242233 55432 YOD1 deubiquitinase "GO:0004843,GO:0005515,GO:0005737,GO:0005829,GO:0008234,GO:0016236,GO:0016579,GO:0018215,GO:0030433,GO:0030968,GO:0031625,GO:0035523,GO:0035871,GO:0046872,GO:0061578,GO:0070536,GO:0071108,GO:0101005,GO:1904153,GO:1990167,GO:1990168,GO:1990380" "thiol-dependent ubiquitin-specific protease activity|protein binding|cytoplasm|cytosol|cysteine-type peptidase activity|macroautophagy|protein deubiquitination|protein phosphopantetheinylation|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|ubiquitin protein ligase binding|protein K29-linked deubiquitination|protein K11-linked deubiquitination|metal ion binding|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|ubiquitinyl hydrolase activity|negative regulation of retrograde protein transport, ER to cytosol|protein K27-linked deubiquitination|protein K33-linked deubiquitination|Lys48-specific deubiquitinase activity" hsa04141 Protein processing in endoplasmic reticulum YPEL1 94.0724628 65.97213794 122.1727877 1.851884621 0.888994216 0.199973529 1 0.777578788 1.502014964 29799 yippee like 1 "GO:0005634,GO:0046872" nucleus|metal ion binding YPEL2 220.9973826 188.7818101 253.2129551 1.34129954 0.423631457 0.418505383 1 1.764697804 2.468948611 388403 yippee like 2 "GO:0005515,GO:0005730,GO:0046872" protein binding|nucleolus|metal ion binding YPEL3 352.5868437 226.3351809 478.8385064 2.115616779 1.081078322 0.017065545 0.570200991 7.159949065 15.80021022 83719 yippee like 3 "GO:0005730,GO:0046872,GO:2000774" nucleolus|metal ion binding|positive regulation of cellular senescence YPEL4 24.79491395 11.16451565 38.42531225 3.441735714 1.783136319 0.094858508 1 0.300448104 1.078606209 219539 yippee like 4 "GO:0005730,GO:0046872" nucleolus|metal ion binding YPEL5 860.8736729 656.6765115 1065.070834 1.621910965 0.697694624 0.054567853 1 9.478013307 16.03467839 51646 yippee like 5 "GO:0000151,GO:0005515,GO:0005576,GO:0005634,GO:0005813,GO:0008283,GO:0030496,GO:0043312,GO:0046872,GO:0097431,GO:1904724,GO:1904813" ubiquitin ligase complex|protein binding|extracellular region|nucleus|centrosome|cell population proliferation|midbody|neutrophil degranulation|metal ion binding|mitotic spindle pole|tertiary granule lumen|ficolin-1-rich granule lumen YRDC 309.972055 344.0700733 275.8740366 0.801796082 -0.318692727 0.497843163 1 9.429618726 7.886312683 79693 yrdC N6-threonylcarbamoyltransferase domain containing "GO:0000049,GO:0003725,GO:0005515,GO:0005737,GO:0005739,GO:0006450,GO:0016020,GO:0016779,GO:0051051" tRNA binding|double-stranded RNA binding|protein binding|cytoplasm|mitochondrion|regulation of translational fidelity|membrane|nucleotidyltransferase activity|negative regulation of transport YTHDC1 1204.266284 1231.14159 1177.390978 0.956340837 -0.064403214 0.852671632 1 9.830203107 9.805982679 91746 YTH domain containing 1 "GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006376,GO:0006406,GO:0009048,GO:0010608,GO:0016607,GO:0048024,GO:1990247" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|plasma membrane|mRNA splice site selection|mRNA export from nucleus|dosage compensation by inactivation of X chromosome|posttranscriptional regulation of gene expression|nuclear speck|regulation of mRNA splicing, via spliceosome|N6-methyladenosine-containing RNA binding" YTHDC2 770.981038 775.4263598 766.5357161 0.988534509 -0.016636764 0.967981118 1 4.994608875 5.150023956 64848 YTH domain containing 2 "GO:0003723,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005783,GO:0007286,GO:0008186,GO:0034458,GO:0034612,GO:0035770,GO:0044829,GO:0048599,GO:0051321,GO:0051729,GO:0070063,GO:0070555,GO:1990247" "RNA binding|protein binding|ATP binding|intracellular anatomical structure|nucleus|endoplasmic reticulum|spermatid development|RNA-dependent ATPase activity|3'-5' RNA helicase activity|response to tumor necrosis factor|ribonucleoprotein granule|positive regulation by host of viral genome replication|oocyte development|meiotic cell cycle|germline cell cycle switching, mitotic to meiotic cell cycle|RNA polymerase binding|response to interleukin-1|N6-methyladenosine-containing RNA binding" YTHDF1 1990.184148 2084.719559 1895.648737 0.909306352 -0.137161664 0.671221516 1 31.9273333 30.28229603 54915 YTH N6-methyladenosine RNA binding protein 1 "GO:0002376,GO:0002577,GO:0003723,GO:0003729,GO:0005515,GO:0005737,GO:0007612,GO:0007613,GO:0043022,GO:0045727,GO:0045948,GO:0061157,GO:1900271,GO:1902667,GO:1990247" immune system process|regulation of antigen processing and presentation|RNA binding|mRNA binding|protein binding|cytoplasm|learning|memory|ribosome binding|positive regulation of translation|positive regulation of translational initiation|mRNA destabilization|regulation of long-term synaptic potentiation|regulation of axon guidance|N6-methyladenosine-containing RNA binding YTHDF2 1262.421133 1300.158595 1224.68367 0.941949447 -0.086278461 0.801128467 1 22.47387242 22.0811372 51441 YTH N6-methyladenosine RNA binding protein 2 "GO:0000932,GO:0001556,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006402,GO:0006959,GO:0016032,GO:0034451,GO:0036464,GO:0043488,GO:0045087,GO:0045746,GO:0045948,GO:0048598,GO:0050767,GO:0060339,GO:0061157,GO:0071425,GO:0098508,GO:1902036,GO:1903538,GO:1903679,GO:1990247" P-body|oocyte maturation|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA catabolic process|humoral immune response|viral process|centriolar satellite|cytoplasmic ribonucleoprotein granule|regulation of mRNA stability|innate immune response|negative regulation of Notch signaling pathway|positive regulation of translational initiation|embryonic morphogenesis|regulation of neurogenesis|negative regulation of type I interferon-mediated signaling pathway|mRNA destabilization|hematopoietic stem cell proliferation|endothelial to hematopoietic transition|regulation of hematopoietic stem cell differentiation|regulation of meiotic cell cycle process involved in oocyte maturation|positive regulation of cap-independent translational initiation|N6-methyladenosine-containing RNA binding YTHDF3 3069.586353 3367.623903 2771.548804 0.822998317 -0.281038615 0.377089387 1 32.2233649 27.66213943 253943 YTH N6-methyladenosine RNA binding protein 3 "GO:0003723,GO:0003729,GO:0005515,GO:0005737,GO:0005829,GO:0043022,GO:0045727,GO:0045948,GO:0060339,GO:0061157,GO:1990247" RNA binding|mRNA binding|protein binding|cytoplasm|cytosol|ribosome binding|positive regulation of translation|positive regulation of translational initiation|negative regulation of type I interferon-mediated signaling pathway|mRNA destabilization|N6-methyladenosine-containing RNA binding YWHAB 10563.37887 10094.75206 11032.00567 1.09284563 0.128089627 0.70485886 1 154.2738623 175.8600134 7529 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta "GO:0000165,GO:0004860,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005774,GO:0005829,GO:0005925,GO:0006469,GO:0006605,GO:0008022,GO:0016020,GO:0016032,GO:0017053,GO:0019899,GO:0019904,GO:0035308,GO:0035329,GO:0042470,GO:0042802,GO:0042826,GO:0043085,GO:0043488,GO:0044877,GO:0045296,GO:0045744,GO:0045892,GO:0048471,GO:0050815,GO:0051219,GO:0051220,GO:0061024,GO:0070062,GO:1900740" "MAPK cascade|protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|mitochondrion|vacuolar membrane|cytosol|focal adhesion|negative regulation of protein kinase activity|protein targeting|protein C-terminus binding|membrane|viral process|transcription repressor complex|enzyme binding|protein domain specific binding|negative regulation of protein dephosphorylation|hippo signaling|melanosome|identical protein binding|histone deacetylase binding|positive regulation of catalytic activity|regulation of mRNA stability|protein-containing complex binding|cadherin binding|negative regulation of G protein-coupled receptor signaling pathway|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm|phosphoserine residue binding|phosphoprotein binding|cytoplasmic sequestering of protein|membrane organization|extracellular exosome|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" "hsa04110,hsa04114,hsa04151,hsa04390,hsa05160,hsa05161,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis C|Hepatitis B|Viral carcinogenesis YWHAE 13320.74873 12998.54109 13642.95638 1.04957597 0.069806596 0.840146632 1 309.0752347 338.371687 7531 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon "GO:0000086,GO:0000165,GO:0003064,GO:0003723,GO:0005246,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005871,GO:0005886,GO:0005925,GO:0010389,GO:0015459,GO:0016020,GO:0016032,GO:0019899,GO:0021762,GO:0023026,GO:0031625,GO:0034504,GO:0034605,GO:0035329,GO:0035556,GO:0042470,GO:0042802,GO:0042826,GO:0043154,GO:0044325,GO:0045296,GO:0046827,GO:0046982,GO:0050815,GO:0051219,GO:0051480,GO:0060306,GO:0061024,GO:0070062,GO:0086013,GO:0086091,GO:0090724,GO:0097110,GO:0097711,GO:0098978,GO:0099072,GO:1900034,GO:1900740,GO:1901016,GO:1901020,GO:1902309,GO:1905913" G2/M transition of mitotic cell cycle|MAPK cascade|regulation of heart rate by hormone|RNA binding|calcium channel regulator activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|kinesin complex|plasma membrane|focal adhesion|regulation of G2/M transition of mitotic cell cycle|potassium channel regulator activity|membrane|viral process|enzyme binding|substantia nigra development|MHC class II protein complex binding|ubiquitin protein ligase binding|protein localization to nucleus|cellular response to heat|hippo signaling|intracellular signal transduction|melanosome|identical protein binding|histone deacetylase binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|ion channel binding|cadherin binding|positive regulation of protein export from nucleus|protein heterodimerization activity|phosphoserine residue binding|phosphoprotein binding|regulation of cytosolic calcium ion concentration|regulation of membrane repolarization|membrane organization|extracellular exosome|membrane repolarization during cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|central region of growth cone|scaffold protein binding|ciliary basal body-plasma membrane docking|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels|regulation of cellular response to heat|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of potassium ion transmembrane transporter activity|negative regulation of calcium ion transmembrane transporter activity|negative regulation of peptidyl-serine dephosphorylation|negative regulation of calcium ion export across plasma membrane "hsa04110,hsa04114,hsa04151,hsa04390,hsa04621,hsa04722,hsa05160,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|NOD-like receptor signaling pathway|Neurotrophin signaling pathway|Hepatitis C|Viral carcinogenesis YWHAG 6842.542636 8074.989684 5610.095588 0.694749567 -0.525435064 0.10881213 1 110.3831959 79.99211475 7532 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma "GO:0000086,GO:0003723,GO:0005080,GO:0005159,GO:0005515,GO:0005739,GO:0005829,GO:0005925,GO:0006469,GO:0006605,GO:0008426,GO:0009966,GO:0010389,GO:0016020,GO:0019904,GO:0030971,GO:0032869,GO:0042802,GO:0045664,GO:0048167,GO:0061024,GO:0070062,GO:0071901,GO:0097711,GO:0098793,GO:1900740" G2/M transition of mitotic cell cycle|RNA binding|protein kinase C binding|insulin-like growth factor receptor binding|protein binding|mitochondrion|cytosol|focal adhesion|negative regulation of protein kinase activity|protein targeting|protein kinase C inhibitor activity|regulation of signal transduction|regulation of G2/M transition of mitotic cell cycle|membrane|protein domain specific binding|receptor tyrosine kinase binding|cellular response to insulin stimulus|identical protein binding|regulation of neuron differentiation|regulation of synaptic plasticity|membrane organization|extracellular exosome|negative regulation of protein serine/threonine kinase activity|ciliary basal body-plasma membrane docking|presynapse|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway "hsa04110,hsa04114,hsa04151,hsa04390,hsa05160,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis C|Viral carcinogenesis YWHAH 4172.376091 4161.31947 4183.432713 1.005313998 0.00764618 0.981711719 1 120.3633072 126.2152325 7533 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta "GO:0002028,GO:0003779,GO:0005159,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006713,GO:0006886,GO:0014704,GO:0017080,GO:0019899,GO:0019904,GO:0021762,GO:0035259,GO:0042802,GO:0042921,GO:0044325,GO:0045664,GO:0045893,GO:0046982,GO:0048167,GO:0050774,GO:0061024,GO:0070062,GO:0086010,GO:1900740,GO:2000649" "regulation of sodium ion transport|actin binding|insulin-like growth factor receptor binding|protein binding|cytoplasm|mitochondrion|cytosol|plasma membrane|glucocorticoid catabolic process|intracellular protein transport|intercalated disc|sodium channel regulator activity|enzyme binding|protein domain specific binding|substantia nigra development|glucocorticoid receptor binding|identical protein binding|glucocorticoid receptor signaling pathway|ion channel binding|regulation of neuron differentiation|positive regulation of transcription, DNA-templated|protein heterodimerization activity|regulation of synaptic plasticity|negative regulation of dendrite morphogenesis|membrane organization|extracellular exosome|membrane depolarization during action potential|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of sodium ion transmembrane transporter activity" "hsa04110,hsa04114,hsa04151,hsa04390,hsa05160,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis C|Viral carcinogenesis YWHAQ 5829.456244 5634.02058 6024.891907 1.069376979 0.096770524 0.765328489 1 129.9377353 144.9379297 10971 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta "GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005925,GO:0006605,GO:0007264,GO:0008022,GO:0016020,GO:0019904,GO:0021762,GO:0032991,GO:0034766,GO:0042802,GO:0044325,GO:0045202,GO:0045892,GO:0047485,GO:0061024,GO:0070062,GO:0071889,GO:1900740" "protein binding|cytoplasm|mitochondrion|cytosol|focal adhesion|protein targeting|small GTPase mediated signal transduction|protein C-terminus binding|membrane|protein domain specific binding|substantia nigra development|protein-containing complex|negative regulation of ion transmembrane transport|identical protein binding|ion channel binding|synapse|negative regulation of transcription, DNA-templated|protein N-terminus binding|membrane organization|extracellular exosome|14-3-3 protein binding|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" "hsa04110,hsa04114,hsa04151,hsa04390,hsa05160,hsa05161,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis C|Hepatitis B|Viral carcinogenesis YWHAZ 33275.91969 34325.81085 32226.02854 0.938827889 -0.091067396 0.818369081 1 256.4131601 251.0974042 7534 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta "GO:0003723,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005925,GO:0006468,GO:0007165,GO:0008134,GO:0019221,GO:0019901,GO:0030168,GO:0031625,GO:0031982,GO:0042470,GO:0042802,GO:0043066,GO:0043488,GO:0044325,GO:0045296,GO:0051683,GO:0061024,GO:0070062,GO:0070372,GO:0072562,GO:0090128,GO:0090168,GO:0098978,GO:1900740" RNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|focal adhesion|protein phosphorylation|signal transduction|transcription factor binding|cytokine-mediated signaling pathway|protein kinase binding|platelet activation|ubiquitin protein ligase binding|vesicle|melanosome|identical protein binding|negative regulation of apoptotic process|regulation of mRNA stability|ion channel binding|cadherin binding|establishment of Golgi localization|membrane organization|extracellular exosome|regulation of ERK1 and ERK2 cascade|blood microparticle|regulation of synapse maturation|Golgi reassembly|glutamatergic synapse|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway "hsa04110,hsa04114,hsa04151,hsa04390,hsa05160,hsa05161,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis C|Hepatitis B|Viral carcinogenesis YY1 3268.420976 3118.959691 3417.882261 1.095840472 0.132037792 0.678458336 1 24.17574308 27.63395828 7528 YY1 transcription factor "GO:0000122,GO:0000400,GO:0000724,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001217,GO:0001227,GO:0003677,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005677,GO:0005737,GO:0006357,GO:0006403,GO:0006974,GO:0007283,GO:0009952,GO:0010225,GO:0010629,GO:0016363,GO:0016579,GO:0030183,GO:0031011,GO:0031519,GO:0032688,GO:0034644,GO:0034696,GO:0045944,GO:0046332,GO:0046872,GO:0048468,GO:0048593,GO:0051276,GO:0061052,GO:0071347,GO:0071707,GO:1902894,GO:1990837" "negative regulation of transcription by RNA polymerase II|four-way junction DNA binding|double-strand break repair via homologous recombination|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|chromatin silencing complex|cytoplasm|regulation of transcription by RNA polymerase II|RNA localization|cellular response to DNA damage stimulus|spermatogenesis|anterior/posterior pattern specification|response to UV-C|negative regulation of gene expression|nuclear matrix|protein deubiquitination|B cell differentiation|Ino80 complex|PcG protein complex|negative regulation of interferon-beta production|cellular response to UV|response to prostaglandin F|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|cell development|camera-type eye morphogenesis|chromosome organization|negative regulation of cell growth involved in cardiac muscle cell development|cellular response to interleukin-1|immunoglobulin heavy chain V-D-J recombination|negative regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" chromosome_remodelling_factor YY1AP1 1192.398573 1228.096722 1156.700425 0.941864272 -0.08640892 0.802625899 1 18.53360146 18.20807664 55249 YY1 associated protein 1 "GO:0001650,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006355,GO:0008283,GO:0030154,GO:0031011,GO:0051726" "fibrillar center|transcription coregulator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|regulation of transcription, DNA-templated|cell population proliferation|cell differentiation|Ino80 complex|regulation of cell cycle" YY2 129.8779914 156.3032191 103.4527637 0.661872253 -0.595375304 0.339336867 1 2.874439595 1.984464303 404281 YY2 transcription factor "GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0005634,GO:0005667,GO:0006357,GO:0031519,GO:0043565,GO:0045944,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|PcG protein complex|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZACN 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.104550385 0.105863723 353174 zinc activated ion channel "GO:0004888,GO:0005230,GO:0005886,GO:0005887,GO:0007165,GO:0007268,GO:0008270,GO:0010043,GO:0015276,GO:0030594,GO:0034220,GO:0042391,GO:0043005,GO:0045202,GO:0050877" transmembrane signaling receptor activity|extracellular ligand-gated ion channel activity|plasma membrane|integral component of plasma membrane|signal transduction|chemical synaptic transmission|zinc ion binding|response to zinc ion|ligand-gated ion channel activity|neurotransmitter receptor activity|ion transmembrane transport|regulation of membrane potential|neuron projection|synapse|nervous system process ZADH2 561.522037 600.8539333 522.1901408 0.869080007 -0.202439097 0.612199708 1 3.521714158 3.192491814 284273 zinc binding alcohol dehydrogenase domain containing 2 "GO:0003674,GO:0005777,GO:0006693,GO:0008150,GO:0008270,GO:0036132,GO:0045599,GO:0047522,GO:0055114" molecular_function|peroxisome|prostaglandin metabolic process|biological_process|zinc ion binding|13-prostaglandin reductase activity|negative regulation of fat cell differentiation|15-oxoprostaglandin 13-oxidase activity|oxidation-reduction process ZAR1 10.98636634 10.14955968 11.823173 1.164895165 0.220200125 0.941332157 1 0.352081776 0.427805455 326340 zygote arrest 1 "GO:0005515,GO:0005737,GO:0006412,GO:0007275,GO:0016441,GO:1903231" protein binding|cytoplasm|translation|multicellular organism development|posttranscriptional gene silencing|mRNA binding involved in posttranscriptional gene silencing ZBBX 6.508139139 7.104691779 5.911586499 0.832067975 -0.265226703 0.975312627 1 0.073916922 0.064153242 79740 zinc finger B-box domain containing "GO:0003341,GO:0031514,GO:0046872" cilium movement|motile cilium|metal ion binding ZBED1-2 9.523315492 11.16451565 7.882115332 0.705997069 -0.5022659 0.780585832 1 0.117482512 0.086515128 9189 zinc finger BED-type containing 1 ZBED3 668.7876897 524.7322356 812.8431437 1.549062719 0.631395558 0.098322402 1 4.332545907 7.000484604 84327 zinc finger BED-type containing 3 "GO:0000785,GO:0000981,GO:0001933,GO:0003677,GO:0005615,GO:0005737,GO:0005829,GO:0007015,GO:0009749,GO:0016020,GO:0016055,GO:0032868,GO:0040019,GO:0045944,GO:0046872,GO:0050821,GO:0051293,GO:0051643,GO:0051646,GO:0090263" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|negative regulation of protein phosphorylation|DNA binding|extracellular space|cytoplasm|cytosol|actin filament organization|response to glucose|membrane|Wnt signaling pathway|response to insulin|positive regulation of embryonic development|positive regulation of transcription by RNA polymerase II|metal ion binding|protein stabilization|establishment of spindle localization|endoplasmic reticulum localization|mitochondrion localization|positive regulation of canonical Wnt signaling pathway" ZBED4 1114.965004 1053.524295 1176.405713 1.116638429 0.159162112 0.64678016 1 6.552534562 7.631990478 9889 zinc finger BED-type containing 4 "GO:0000785,GO:0000976,GO:0000981,GO:0001917,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0042802,GO:0045944,GO:0046872,GO:0046983" "chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|photoreceptor inner segment|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|identical protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding|protein dimerization activity" zf-BED ZBED5 645.1507462 592.7342855 697.5672069 1.176863266 0.23494671 0.542538335 1 11.04078725 13.55320408 58486 zinc finger BED-type containing 5 "GO:0000785,GO:0000981,GO:0003677,GO:0006357,GO:0046872" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|regulation of transcription by RNA polymerase II|metal ion binding" ZBED6 1224.226672 1214.902294 1233.55105 1.015350004 0.021977129 0.951151398 1 17.3227802 18.34633417 100381270 zinc finger BED-type containing 6 "GO:0000122,GO:0000785,GO:0000976,GO:0000981,GO:0001835,GO:0003309,GO:0005634,GO:0005730,GO:0005737,GO:0006357,GO:0045787,GO:0045892,GO:0046872,GO:0046983,GO:0051148,GO:0060548,GO:0061178" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|blastocyst hatching|type B pancreatic cell differentiation|nucleus|nucleolus|cytoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|metal ion binding|protein dimerization activity|negative regulation of muscle cell differentiation|negative regulation of cell death|regulation of insulin secretion involved in cellular response to glucose stimulus" ZBED6CL 343.4886125 311.5914823 375.3857427 1.204736856 0.268718061 0.555859913 1 5.492867856 6.902513704 113763 ZBED6 C-terminal like ZBED8 190.7120071 139.0489677 242.3750465 1.743091305 0.801648141 0.143845483 1 2.443559916 4.442823481 63920 zinc finger BED-type containing 8 "GO:0005515,GO:0005654" protein binding|nucleoplasm ZBED9 79.90489497 74.09178569 85.71800424 1.156916431 0.210284656 0.786472447 1 0.425307442 0.513240479 114821 zinc finger BED-type containing 9 "GO:0003676,GO:0005634,GO:0005737,GO:0015074,GO:0045787,GO:0050679" nucleic acid binding|nucleus|cytoplasm|DNA integration|positive regulation of cell cycle|positive regulation of epithelial cell proliferation ZBTB1 954.4911138 994.656849 914.3253786 0.919237001 -0.121491225 0.734275403 1 8.675023328 8.317907339 22890 zinc finger and BTB domain containing 1 "GO:0000122,GO:0000978,GO:0001227,GO:0002711,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0006281,GO:0006338,GO:0006357,GO:0006974,GO:0016604,GO:0019985,GO:0030183,GO:0031965,GO:0032825,GO:0033077,GO:0034644,GO:0042789,GO:0042803,GO:0045087,GO:0045582,GO:0046872,GO:0046982,GO:0048538,GO:0051260,GO:0070530,GO:2000176" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|positive regulation of T cell mediated immunity|protein binding|nucleus|nucleoplasm|centrosome|DNA repair|chromatin remodeling|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|nuclear body|translesion synthesis|B cell differentiation|nuclear membrane|positive regulation of natural killer cell differentiation|T cell differentiation in thymus|cellular response to UV|mRNA transcription by RNA polymerase II|protein homodimerization activity|innate immune response|positive regulation of T cell differentiation|metal ion binding|protein heterodimerization activity|thymus development|protein homooligomerization|K63-linked polyubiquitin modification-dependent protein binding|positive regulation of pro-T cell differentiation" ZBTB10 977.7635938 1002.776497 952.7506908 0.950112706 -0.073829433 0.837117593 1 5.002175906 4.95735495 65986 zinc finger and BTB domain containing 10 "GO:0000977,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0046872" RNA polymerase II transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding ZBTB ZBTB11 853.9523276 958.1184341 749.786221 0.782561105 -0.353724687 0.329647852 1 5.84783305 4.773414568 27107 zinc finger and BTB domain containing 11 "GO:0000978,GO:0000981,GO:0003674,GO:0005654,GO:0005730,GO:0006355,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZBTB12 256.1887912 304.4867905 207.8907919 0.682757999 -0.550553783 0.268734336 1 6.289225846 4.47898819 221527 zinc finger and BTB domain containing 12 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB ZBTB14 545.9413989 546.046311 545.8364868 0.999615739 -0.000554478 1 1 5.951219995 6.205189088 7541 zinc finger and BTB domain containing 14 "GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0001822,GO:0003170,GO:0003279,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0016235,GO:0043565,GO:0045892,GO:0046872,GO:0060976,GO:1990837" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|kidney development|heart valve development|cardiac septum development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|aggresome|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|coronary vasculature development|sequence-specific double-stranded DNA binding" other ZBTB17 439.3925489 435.4161104 443.3689874 1.018265004 0.026113072 0.956523124 1 4.738351942 5.032734995 7709 zinc finger and BTB domain containing 17 "GO:0000122,GO:0000978,GO:0001046,GO:0001223,GO:0001227,GO:0001228,GO:0001702,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0007398,GO:0008134,GO:0008285,GO:0032991,GO:0032993,GO:0036498,GO:0045786,GO:0045944,GO:0046872,GO:0071158" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|core promoter sequence-specific DNA binding|transcription coactivator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|gastrulation with mouth forming second|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|ectoderm development|transcription factor binding|negative regulation of cell population proliferation|protein-containing complex|protein-DNA complex|IRE1-mediated unfolded protein response|negative regulation of cell cycle|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of cell cycle arrest" "hsa04110,hsa05200,hsa05202,hsa05222" Cell cycle|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer ZBTB ZBTB18 488.733958 575.4800341 401.987882 0.698526201 -0.517613864 0.208030778 1 4.267979727 3.109717791 10472 zinc finger and BTB domain containing 18 "GO:0000122,GO:0000792,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007519,GO:0016607,GO:0043565,GO:0045892,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|skeletal muscle tissue development|nuclear speck|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" other ZBTB2 534.6499522 616.0782728 453.2216316 0.735655925 -0.442896937 0.27062927 1 8.134043567 6.24161765 57621 zinc finger and BTB domain containing 2 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0042802,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB ZBTB20 798.0461179 773.3964479 822.6957878 1.063743944 0.089150919 0.811075012 1 1.366563225 1.516291707 26137 zinc finger and BTB domain containing 20 "GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0016604,GO:0045821,GO:0046872,GO:0046889,GO:0055088,GO:0071333,GO:1990837" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|nuclear body|positive regulation of glycolytic process|metal ion binding|positive regulation of lipid biosynthetic process|lipid homeostasis|cellular response to glucose stimulus|sequence-specific double-stranded DNA binding" ZBTB21 743.1924744 862.7125731 623.6723757 0.722920235 -0.468091623 0.209560704 1 5.31161541 4.005280468 49854 zinc finger and BTB domain containing 21 "GO:0000122,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0008327,GO:0031208,GO:0043565,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|methyl-CpG binding|POZ domain binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding" ZBTB22 407.7628888 394.8178717 420.7079059 1.065574626 0.091631633 0.836654402 1 7.338030227 8.156039047 9278 zinc finger and BTB domain containing 22 "GO:0000785,GO:0000977,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB24 228.0399697 232.4249168 223.6550226 0.96226784 -0.055489582 0.923084274 1 2.091967672 2.099746519 9841 zinc finger and BTB domain containing 24 "GO:0000978,GO:0002244,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|hematopoietic progenitor cell differentiation|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZBTB25 380.3954502 443.5357582 317.2551421 0.715286505 -0.483406873 0.272180745 1 1.677383621 1.25149281 7597 zinc finger and BTB domain containing 25 "GO:0000122,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB26 374.3584165 333.9205136 414.7963194 1.242200771 0.312898368 0.480581594 1 3.63150011 4.705370071 57684 zinc finger and BTB domain containing 26 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005575,GO:0005654,GO:0006357,GO:0008150,GO:0042802,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|cellular_component|nucleoplasm|regulation of transcription by RNA polymerase II|biological_process|identical protein binding|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB ZBTB3 90.92095286 86.27125731 95.57064841 1.10779246 0.147687625 0.846624563 1 1.481130453 1.711463519 79842 zinc finger and BTB domain containing 3 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB33 1260.203669 1215.91725 1304.490088 1.072844462 0.101440933 0.766736207 1 11.72319041 13.11893294 10009 zinc finger and BTB domain containing 33 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006357,GO:0008327,GO:0016055,GO:0035556,GO:0043565,GO:0045892,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|methyl-CpG binding|Wnt signaling pathway|intracellular signal transduction|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|sequence-specific double-stranded DNA binding" other ZBTB34 435.3827056 363.3542367 507.4111745 1.396464175 0.481778564 0.255688158 1 2.705868292 3.941416969 403341 zinc finger and BTB domain containing 34 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB37 226.2921275 247.6492563 204.9349986 0.827521155 -0.273131901 0.601602821 1 0.639926591 0.552363778 84614 zinc finger and BTB domain containing 37 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005654,GO:0006357,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB38 2078.700085 2006.567949 2150.832221 1.071896031 0.100164978 0.756290805 1 8.6313562 9.650451492 253461 zinc finger and BTB domain containing 38 "GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006275,GO:0006355,GO:0006974,GO:0008327,GO:0042803,GO:0045892,GO:0045944,GO:0046872,GO:0072562" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of DNA replication|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|methyl-CpG binding|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|blood microparticle" ZBTB39 377.4626675 344.0700733 410.8552617 1.19410345 0.255927829 0.563938797 1 2.780142853 3.462780754 9880 zinc finger and BTB domain containing 39 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB4 2925.515554 2611.481707 3239.549402 1.240502429 0.310924561 0.328670571 1 19.39046118 25.09005927 57659 zinc finger and BTB domain containing 4 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006974,GO:0008327,GO:0010428,GO:0016604,GO:0019901,GO:0042803,GO:0043565,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|methyl-CpG binding|methyl-CpNpG binding|nuclear body|protein kinase binding|protein homodimerization activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding" ZBTB40 1201.047472 977.4025975 1424.692346 1.457631021 0.543625568 0.112302908 1 5.104877127 7.761556535 9923 zinc finger and BTB domain containing 40 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006357,GO:0006974,GO:0030282,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|bone mineralization|metal ion binding" ZBTB41 519.4216533 450.64045 588.2028567 1.305259785 0.384336974 0.342797882 1 2.309354349 3.144151496 360023 zinc finger and BTB domain containing 41 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB42 173.482004 173.5574706 173.4065373 0.999130356 -0.001255177 1 1 2.338407452 2.43701538 100128927 zinc finger and BTB domain containing 42 "GO:0000122,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006357,GO:0007517,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|regulation of transcription by RNA polymerase II|muscle organ development|metal ion binding" ZBTB ZBTB43 403.9257515 401.9225635 405.9289396 1.00996803 0.014309626 0.980003682 1 2.952278454 3.110146693 23099 zinc finger and BTB domain containing 43 "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB44 707.1009167 618.1081847 796.0936486 1.287951961 0.365078784 0.333025021 1 3.615731 4.857487673 29068 zinc finger and BTB domain containing 44 "GO:0003677,GO:0005515,GO:0005634,GO:0046872" DNA binding|protein binding|nucleus|metal ion binding ZBTB45 297.3472101 289.262451 305.4319691 1.055899126 0.078472015 0.87518392 1 4.665644167 5.138661067 84878 zinc finger and BTB domain containing 45 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0007399,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|nervous system development|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB46 393.0339031 330.8756457 455.1921604 1.37571975 0.460186606 0.291454464 1 2.357580782 3.383081687 140685 zinc finger and BTB domain containing 46 "GO:0000785,GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0030853,GO:0045650,GO:0045656,GO:0046872,GO:2001199,GO:2001200" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation|negative regulation of monocyte differentiation|metal ion binding|negative regulation of dendritic cell differentiation|positive regulation of dendritic cell differentiation" ZBTB47 504.2809452 493.2686006 515.2932899 1.044650499 0.063020351 0.881746538 1 4.547199577 4.954855136 92999 zinc finger and BTB domain containing 47 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB48 296.139259 274.0381115 318.2404065 1.161299809 0.215740476 0.653351882 1 4.687289293 5.677825524 3104 zinc finger and BTB domain containing 48 "GO:0000781,GO:0000976,GO:0000978,GO:0003691,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0010833,GO:0042802,GO:0045893,GO:0046872" "chromosome, telomeric region|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|double-stranded telomeric DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|telomere maintenance via telomere lengthening|identical protein binding|positive regulation of transcription, DNA-templated|metal ion binding" ZBTB ZBTB49 66.12603891 75.10674166 57.14533616 0.76085495 -0.394306652 0.620658264 1 1.293840648 1.0268301 166793 zinc finger and BTB domain containing 49 "GO:0000122,GO:0000978,GO:0001223,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007050,GO:0008134,GO:0008285,GO:0015630,GO:0043565,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription coactivator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|cell cycle arrest|transcription factor binding|negative regulation of cell population proliferation|microtubule cytoskeleton|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding" ZBTB5 697.7260589 617.0932288 778.3588891 1.261331113 0.334947048 0.375969966 1 5.225479863 6.87497648 9925 zinc finger and BTB domain containing 5 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB6 356.1013332 331.8906017 380.3120648 1.145895855 0.196475931 0.664855608 1 4.100777783 4.901480896 10773 zinc finger and BTB domain containing 6 "GO:0000122,GO:0000978,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB ZBTB7A 1402.910387 1306.248331 1499.572442 1.147999508 0.199122024 0.55219253 1 8.578432289 10.2722495 51341 zinc finger and BTB domain containing 7A "GO:0000122,GO:0000381,GO:0000978,GO:0000981,GO:0001222,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006110,GO:0006325,GO:0006338,GO:0006351,GO:0006357,GO:0016581,GO:0030183,GO:0030512,GO:0033613,GO:0034504,GO:0035035,GO:0035861,GO:0042981,GO:0043249,GO:0045444,GO:0045746,GO:0045892,GO:0046332,GO:0046872,GO:0050681,GO:0051090,GO:0051092,GO:0060766,GO:0070418,GO:0097680,GO:1990837,GO:2000677" "negative regulation of transcription by RNA polymerase II|regulation of alternative mRNA splicing, via spliceosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription corepressor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of glycolytic process|chromatin organization|chromatin remodeling|transcription, DNA-templated|regulation of transcription by RNA polymerase II|NuRD complex|B cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|activating transcription factor binding|protein localization to nucleus|histone acetyltransferase binding|site of double-strand break|regulation of apoptotic process|erythrocyte maturation|fat cell differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|SMAD binding|metal ion binding|androgen receptor binding|regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|negative regulation of androgen receptor signaling pathway|DNA-dependent protein kinase complex|double-strand break repair via classical nonhomologous end joining|sequence-specific double-stranded DNA binding|regulation of transcription regulatory region DNA binding" ZBTB ZBTB7B 824.7346102 812.9797307 836.4894896 1.028918014 0.04112803 0.913623673 1 8.086126343 8.678351235 51043 zinc finger and BTB domain containing 7B "GO:0000122,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0001865,GO:0005515,GO:0005654,GO:0006357,GO:0006366,GO:0007398,GO:0007595,GO:0010628,GO:0031065,GO:0032620,GO:0032868,GO:0042803,GO:0042826,GO:0043372,GO:0043377,GO:0045944,GO:0046628,GO:0046872,GO:0051141,GO:0090336,GO:0120162,GO:1990837,GO:1990845,GO:2000320,GO:2000640" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|NK T cell differentiation|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|ectoderm development|lactation|positive regulation of gene expression|positive regulation of histone deacetylation|interleukin-17 production|response to insulin|protein homodimerization activity|histone deacetylase binding|positive regulation of CD4-positive, alpha-beta T cell differentiation|negative regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of insulin receptor signaling pathway|metal ion binding|negative regulation of NK T cell proliferation|positive regulation of brown fat cell differentiation|positive regulation of cold-induced thermogenesis|sequence-specific double-stranded DNA binding|adaptive thermogenesis|negative regulation of T-helper 17 cell differentiation|positive regulation of SREBP signaling pathway" ZBTB ZBTB8A 217.0563249 188.7818101 245.3308397 1.299547025 0.37800884 0.473648513 1 1.351014936 1.831336197 653121 zinc finger and BTB domain containing 8A "GO:0000977,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" RNA polymerase II transcription regulatory region sequence-specific DNA binding|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding ZBTB8B 132.7204617 81.19647747 184.2444459 2.269118706 1.182132084 0.057146694 1 0.320498413 0.75857588 728116 zinc finger and BTB domain containing 8B "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB8OS 281.2833423 302.4568786 260.109806 0.859989719 -0.217608682 0.655994818 1 5.228113958 4.689799051 339487 zinc finger and BTB domain containing 8 opposite strand "GO:0005515,GO:0005654,GO:0006388,GO:0046872,GO:0072669" "protein binding|nucleoplasm|tRNA splicing, via endonucleolytic cleavage and ligation|metal ion binding|tRNA-splicing ligase complex" ZBTB9 302.2586864 288.247495 316.2698777 1.097216396 0.133848086 0.781977585 1 5.377060312 6.15393814 221504 zinc finger and BTB domain containing 9 "GO:0000977,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872" RNA polymerase II transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding ZC2HC1A 569.0208838 540.9715311 597.0702364 1.103699921 0.142347979 0.722010552 1 2.647434498 3.047840004 51101 zinc finger C2HC-type containing 1A "GO:0005515,GO:0046872" protein binding|metal ion binding ZC2HC1C 29.03288713 31.46363502 26.60213925 0.845488426 -0.242143089 0.837684616 1 0.692534601 0.610752247 79696 zinc finger C2HC-type containing 1C "GO:0005515,GO:0046872" protein binding|metal ion binding ZC3H10 169.9593496 168.4826908 171.4360085 1.017528909 0.025069783 0.976333089 1 1.121000252 1.189784746 84872 zinc finger CCCH-type containing 10 "GO:0000381,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0010608,GO:0035198,GO:0046872,GO:1903799" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|cytoplasm|posttranscriptional regulation of gene expression|miRNA binding|metal ion binding|negative regulation of production of miRNAs involved in gene silencing by miRNA" ZC3H11A 4348.373959 4237.441168 4459.306749 1.052358386 0.073626106 0.818200808 1 40.32533754 44.26470837 9877 zinc finger CCCH-type containing 11A "GO:0000346,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0006405,GO:0006406,GO:0016973,GO:0031124,GO:0046872" transcription export complex|RNA binding|mRNA binding|protein binding|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|metal ion binding ZC3H11B 112.863994 104.5404647 121.1875232 1.159240334 0.213179697 0.753028484 1 1.11067878 1.343005797 643136 zinc finger CCCH-type containing 11B "GO:0000346,GO:0003729,GO:0016973,GO:0046872" transcription export complex|mRNA binding|poly(A)+ mRNA export from nucleus|metal ion binding ZC3H12A 1450.337682 1854.324554 1046.35081 0.564275983 -0.825527149 0.013578228 0.521357808 33.54107036 19.74169388 80149 zinc finger CCCH-type containing 12A "GO:0000294,GO:0000932,GO:0001525,GO:0001933,GO:0002230,GO:0002757,GO:0003677,GO:0003682,GO:0003723,GO:0003729,GO:0003730,GO:0004521,GO:0004532,GO:0004540,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005791,GO:0005856,GO:0006915,GO:0006954,GO:0006974,GO:0007399,GO:0010468,GO:0010508,GO:0010595,GO:0010628,GO:0010629,GO:0010656,GO:0010884,GO:0010942,GO:0016032,GO:0016579,GO:0018215,GO:0030154,GO:0030867,GO:0032088,GO:0032689,GO:0032691,GO:0032715,GO:0032720,GO:0032991,GO:0034599,GO:0035198,GO:0035613,GO:0035925,GO:0036464,GO:0042149,GO:0042307,GO:0042406,GO:0043022,GO:0043031,GO:0043124,GO:0044828,GO:0045019,GO:0045600,GO:0045766,GO:0045944,GO:0046872,GO:0050852,GO:0051259,GO:0051607,GO:0055118,GO:0061014,GO:0061158,GO:0071222,GO:0071347,GO:0071356,GO:0090501,GO:0090502,GO:0090503,GO:0098586,GO:1900016,GO:1900119,GO:1900745,GO:1901223,GO:1903003,GO:1903799,GO:1903936,GO:1904637,GO:1990869,GO:2000320,GO:2000379,GO:2000627" "nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|P-body|angiogenesis|negative regulation of protein phosphorylation|positive regulation of defense response to virus by host|immune response-activating signal transduction|DNA binding|chromatin binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|endoribonuclease activity|exoribonuclease activity|ribonuclease activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|rough endoplasmic reticulum|cytoskeleton|apoptotic process|inflammatory response|cellular response to DNA damage stimulus|nervous system development|regulation of gene expression|positive regulation of autophagy|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|negative regulation of muscle cell apoptotic process|positive regulation of lipid storage|positive regulation of cell death|viral process|protein deubiquitination|protein phosphopantetheinylation|cell differentiation|rough endoplasmic reticulum membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-gamma production|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|protein-containing complex|cellular response to oxidative stress|miRNA binding|RNA stem-loop binding|mRNA 3'-UTR AU-rich region binding|cytoplasmic ribonucleoprotein granule|cellular response to glucose starvation|positive regulation of protein import into nucleus|extrinsic component of endoplasmic reticulum membrane|ribosome binding|negative regulation of macrophage activation|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation by host of viral genome replication|negative regulation of nitric oxide biosynthetic process|positive regulation of fat cell differentiation|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|metal ion binding|T cell receptor signaling pathway|protein complex oligomerization|defense response to virus|negative regulation of cardiac muscle contraction|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|RNA phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic|RNA phosphodiester bond hydrolysis, exonucleolytic|cellular response to virus|negative regulation of cytokine production involved in inflammatory response|positive regulation of execution phase of apoptosis|positive regulation of p38MAPK cascade|negative regulation of NIK/NF-kappaB signaling|positive regulation of protein deubiquitination|negative regulation of production of miRNAs involved in gene silencing by miRNA|cellular response to sodium arsenite|cellular response to ionomycin|cellular response to chemokine|negative regulation of T-helper 17 cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of miRNA catabolic process" ZC3H12B 102.6671754 114.6900244 90.64432632 0.790341852 -0.339451288 0.620255194 1 0.4529158 0.373377705 340554 zinc finger CCCH-type containing 12B "GO:0003729,GO:0004521,GO:0005634,GO:0036464,GO:0046872,GO:0090502" "mRNA binding|endoribonuclease activity|nucleus|cytoplasmic ribonucleoprotein granule|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" ZC3H12C 1978.833318 2150.691697 1806.97494 0.840183157 -0.25122423 0.436188353 1 7.644928921 6.69982336 85463 zinc finger CCCH-type containing 12C "GO:0003674,GO:0003729,GO:0004521,GO:0005515,GO:0005575,GO:0005634,GO:0008150,GO:0036464,GO:0046872,GO:0090502" "molecular_function|mRNA binding|endoribonuclease activity|protein binding|cellular_component|nucleus|biological_process|cytoplasmic ribonucleoprotein granule|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" ZC3H12D 3.970749218 2.029911937 5.911586499 2.912237912 1.542128219 0.515744462 1 0.017898308 0.054369426 340152 zinc finger CCCH-type containing 12D "GO:0000932,GO:0003729,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0006402,GO:0036464,GO:0046872,GO:0061158,GO:0090502" "P-body|mRNA binding|endoribonuclease activity|protein binding|nucleus|nucleoplasm|mRNA catabolic process|cytoplasmic ribonucleoprotein granule|metal ion binding|3'-UTR-mediated mRNA destabilization|RNA phosphodiester bond hydrolysis, endonucleolytic" ZC3H13 1378.282736 1441.237475 1315.327996 0.912637937 -0.131885469 0.695179404 1 5.572455434 5.304702729 23091 zinc finger CCCH-type containing 13 "GO:0003723,GO:0005515,GO:0005654,GO:0006397,GO:0007275,GO:0008380,GO:0016607,GO:0036396,GO:0046872,GO:0080009,GO:2000036" RNA binding|protein binding|nucleoplasm|mRNA processing|multicellular organism development|RNA splicing|nuclear speck|RNA N6-methyladenosine methyltransferase complex|metal ion binding|mRNA methylation|regulation of stem cell population maintenance ZC3H14 1853.372933 1824.890831 1881.855036 1.03121513 0.044345336 0.89274844 1 3.619088526 3.892820804 79882 zinc finger CCCH-type containing 14 "GO:0003723,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0008143,GO:0016607,GO:0032839,GO:0043488,GO:0046872,GO:1900364,GO:1904115,GO:1990904" RNA binding|protein binding|nucleus|nucleolus|cytoplasm|poly(A) binding|nuclear speck|dendrite cytoplasm|regulation of mRNA stability|metal ion binding|negative regulation of mRNA polyadenylation|axon cytoplasm|ribonucleoprotein complex ZC3H15 938.0506584 1049.464471 826.6368455 0.787674922 -0.344327751 0.334177875 1 26.06751995 21.41719855 55854 zinc finger CCCH-type containing 15 "GO:0002181,GO:0003723,GO:0005515,GO:0005634,GO:0005829,GO:0019221,GO:0043547,GO:0045296,GO:0046872" cytoplasmic translation|RNA binding|protein binding|nucleus|cytosol|cytokine-mediated signaling pathway|positive regulation of GTPase activity|cadherin binding|metal ion binding ZC3H18 1028.412915 1030.180308 1026.645522 0.99656877 -0.004958731 0.991869145 1 13.1921614 13.71321102 124245 zinc finger CCCH-type containing 18 "GO:0003723,GO:0005515,GO:0016607,GO:0032991,GO:0046872" RNA binding|protein binding|nuclear speck|protein-containing complex|metal ion binding ZC3H3 844.7989187 803.845127 885.7527105 1.101894732 0.139986404 0.702044179 1 9.608666482 11.04381583 23144 zinc finger CCCH-type containing 3 "GO:0003674,GO:0003677,GO:0005634,GO:0005847,GO:0031124,GO:0032927,GO:0046872,GO:0051028,GO:0070412,GO:1900363" molecular_function|DNA binding|nucleus|mRNA cleavage and polyadenylation specificity factor complex|mRNA 3'-end processing|positive regulation of activin receptor signaling pathway|metal ion binding|mRNA transport|R-SMAD binding|regulation of mRNA polyadenylation ZC3H4 958.2903947 1086.002886 830.5779031 0.764802666 -0.386840542 0.27601842 1 4.717575692 3.763433099 23211 zinc finger CCCH-type containing 4 "GO:0000785,GO:0000981,GO:0003723,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" ZC3H6 179.5920287 119.7648043 239.4192532 1.999078566 0.999335173 0.07470665 1 0.52552979 1.095829863 376940 zinc finger CCCH-type containing 6 "GO:0000785,GO:0000981,GO:0003674,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZC3H7A 839.1139782 954.0586103 724.1693462 0.759040732 -0.397750788 0.274561821 1 10.24590816 8.112065909 29066 zinc finger CCCH-type containing 7A "GO:0003723,GO:0005634,GO:0010608,GO:0035196,GO:0035198,GO:0046872" RNA binding|nucleus|posttranscriptional regulation of gene expression|production of miRNAs involved in gene silencing by miRNA|miRNA binding|metal ion binding ZC3H7B 4928.109779 5005.762836 4850.456723 0.968974536 -0.045469341 0.887864575 1 42.91202241 43.37178308 23264 zinc finger CCCH-type containing 7B "GO:0003723,GO:0005515,GO:0005634,GO:0010608,GO:0016032,GO:0035196,GO:0035198,GO:0046872" RNA binding|protein binding|nucleus|posttranscriptional regulation of gene expression|viral process|production of miRNAs involved in gene silencing by miRNA|miRNA binding|metal ion binding ZC3H8 147.5682136 153.2583512 141.878076 0.925744502 -0.111314019 0.86206684 1 1.244308244 1.201531192 84524 zinc finger CCCH-type containing 8 "GO:0000785,GO:0000981,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006915,GO:0008023,GO:0015030,GO:0016604,GO:0033085,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0043029,GO:0045892,GO:0045945,GO:0046677,GO:0046872,GO:0070245" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|apoptotic process|transcription elongation factor complex|Cajal body|nuclear body|negative regulation of T cell differentiation in thymus|transcriptionally active chromatin|histone locus body|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III|T cell homeostasis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase III|response to antibiotic|metal ion binding|positive regulation of thymocyte apoptotic process" other ZC3HAV1 1896.649847 2560.733908 1232.565785 0.48133302 -1.054892698 0.001234008 0.104535876 15.74124757 7.903159279 56829 "zinc finger CCCH-type containing, antiviral 1" "GO:0003723,GO:0003950,GO:0005515,GO:0005634,GO:0005829,GO:0006471,GO:0009615,GO:0045071,GO:0045087,GO:0045296,GO:0046872,GO:0051607,GO:0061014,GO:0070212,GO:0070403,GO:1990404" RNA binding|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|cytosol|protein ADP-ribosylation|response to virus|negative regulation of viral genome replication|innate immune response|cadherin binding|metal ion binding|defense response to virus|positive regulation of mRNA catabolic process|protein poly-ADP-ribosylation|NAD+ binding|protein ADP-ribosylase activity ZC3HAV1L 504.8072284 630.2876564 379.3268004 0.601831238 -0.732569104 0.072833911 1 6.716146912 4.216099417 92092 "zinc finger CCCH-type containing, antiviral 1 like" GO:0005829 cytosol ZC3HC1 645.8160845 671.9008511 619.731318 0.92235531 -0.116605481 0.764532338 1 6.014388085 5.786362402 51530 zinc finger C3HC-type containing 1 "GO:0005515,GO:0005634,GO:0005654,GO:0007049,GO:0008270,GO:0016567,GO:0019901,GO:0031965,GO:0051301,GO:2001240" protein binding|nucleus|nucleoplasm|cell cycle|zinc ion binding|protein ubiquitination|protein kinase binding|nuclear membrane|cell division|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ZC4H2 632.9091699 597.8090654 668.0092744 1.117429148 0.160183358 0.680617403 1 10.67216081 12.43908072 55906 zinc finger C4H2-type containing "GO:0005515,GO:0005634,GO:0005737,GO:0007399,GO:0007528,GO:0021522,GO:0045211,GO:0045666,GO:0046872" protein binding|nucleus|cytoplasm|nervous system development|neuromuscular junction development|spinal cord motor neuron differentiation|postsynaptic membrane|positive regulation of neuron differentiation|metal ion binding ZCCHC10 181.9161346 177.6172945 186.2149747 1.048405648 0.068197031 0.912254866 1 4.053938427 4.433252114 54819 zinc finger CCHC-type containing 10 "GO:0003676,GO:0005515,GO:0008270" nucleic acid binding|protein binding|zinc ion binding ZCCHC12 9.912027269 4.059823873 15.76423066 3.882983882 1.957165719 0.180513143 1 0.09358933 0.379059909 170261 zinc finger CCHC-type containing 12 "GO:0003676,GO:0005515,GO:0005634,GO:0008270" nucleic acid binding|protein binding|nucleus|zinc ion binding ZCCHC14 875.8199021 802.830171 948.8096331 1.181831061 0.241023822 0.505121685 1 4.399536458 5.423482596 23174 zinc finger CCHC-type containing 14 "GO:0003676,GO:0005515,GO:0008270,GO:0035091" nucleic acid binding|protein binding|zinc ion binding|phosphatidylinositol binding ZCCHC17 716.9805308 653.6316436 780.3294179 1.193836659 0.255605461 0.497325242 1 12.92120877 16.09029417 51538 zinc finger CCHC-type containing 17 "GO:0003723,GO:0005515,GO:0005730,GO:0008270,GO:0042802,GO:0043489" RNA binding|protein binding|nucleolus|zinc ion binding|identical protein binding|RNA stabilization ZCCHC18 24.92852593 20.29911937 29.5579325 1.456118956 0.542128219 0.621829077 1 0.340649034 0.517392283 644353 zinc finger CCHC-type containing 18 "GO:0005634,GO:0046872" nucleus|metal ion binding ZCCHC2 553.7087074 672.915807 434.5016077 0.645699808 -0.631064496 0.113594566 1 4.754577528 3.202274232 54877 zinc finger CCHC-type containing 2 "GO:0003676,GO:0005737,GO:0008270,GO:0035091" nucleic acid binding|cytoplasm|zinc ion binding|phosphatidylinositol binding ZCCHC24 521.4758136 523.7172797 519.2343475 0.991440168 -0.012402385 0.980832827 1 4.992364512 5.162840725 219654 zinc finger CCHC-type containing 24 "GO:0003723,GO:0008270" RNA binding|zinc ion binding ZCCHC3 736.5737339 747.0075927 726.139875 0.972064919 -0.040875428 0.916517597 1 13.74756515 13.93917229 85364 zinc finger CCHC-type containing 3 "GO:0002218,GO:0003690,GO:0003723,GO:0005515,GO:0005737,GO:0008270,GO:0009597,GO:0032481,GO:0045087,GO:0051607,GO:0071360,GO:1900246" activation of innate immune response|double-stranded DNA binding|RNA binding|protein binding|cytoplasm|zinc ion binding|detection of virus|positive regulation of type I interferon production|innate immune response|defense response to virus|cellular response to exogenous dsRNA|positive regulation of RIG-I signaling pathway ZCCHC4 235.5954779 210.0958855 261.0950704 1.242742426 0.313527311 0.542482897 1 1.590763257 2.062066211 29063 zinc finger CCHC-type containing 4 "GO:0003676,GO:0005730,GO:0005737,GO:0008270,GO:0008988,GO:0031167,GO:0045727,GO:1904047" nucleic acid binding|nucleolus|cytoplasm|zinc ion binding|rRNA (adenine-N6-)-methyltransferase activity|rRNA methylation|positive regulation of translation|S-adenosyl-L-methionine binding ZCCHC7 541.6710125 557.2108266 526.1311984 0.944222857 -0.082800689 0.84021679 1 2.957221277 2.912555844 84186 zinc finger CCHC-type containing 7 "GO:0003723,GO:0005515,GO:0005730,GO:0005829,GO:0008270" RNA binding|protein binding|nucleolus|cytosol|zinc ion binding hsa03018 RNA degradation ZCCHC8 542.4984166 479.0592171 605.9376162 1.264849093 0.33896527 0.397972666 1 5.385717941 7.105558974 55596 zinc finger CCHC-type containing 8 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0008270,GO:0016076,GO:0016604,GO:0031499,GO:0034470,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|zinc ion binding|snRNA catabolic process|nuclear body|TRAMP complex|ncRNA processing|catalytic step 2 spliceosome" ZCCHC9 359.086818 333.9205136 384.2531225 1.150732305 0.202552259 0.654117748 1 11.85967462 14.23518152 84240 zinc finger CCHC-type containing 9 "GO:0003723,GO:0005654,GO:0005730,GO:0008270,GO:0010923" RNA binding|nucleoplasm|nucleolus|zinc ion binding|negative regulation of phosphatase activity ZCRB1 698.4804719 702.3495301 694.6114137 0.988982528 -0.015983062 0.970424759 1 19.53406148 20.15102302 85437 zinc finger CCHC-type and RNA binding motif containing 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005689,GO:0008270,GO:0008380" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|U12-type spliceosomal complex|zinc ion binding|RNA splicing" ZCWPW1 47.39389082 40.59823873 54.18954291 1.334775709 0.416597337 0.641548061 1 0.477620806 0.664978282 55063 zinc finger CW-type and PWWP domain containing 1 "GO:0005634,GO:0005694,GO:0007127,GO:0007129,GO:0007283,GO:0008270,GO:0008327,GO:0030154,GO:0035064,GO:0045911,GO:2000781" nucleus|chromosome|meiosis I|homologous chromosome pairing at meiosis|spermatogenesis|zinc ion binding|methyl-CpG binding|cell differentiation|methylated histone binding|positive regulation of DNA recombination|positive regulation of double-strand break repair ZCWPW2 39.42270083 34.50850292 44.33689874 1.284810843 0.361555974 0.709109327 1 0.249604961 0.334509407 152098 zinc finger CW-type and PWWP domain containing 2 "GO:0005515,GO:0008270,GO:0035064" protein binding|zinc ion binding|methylated histone binding ZDBF2 532.2070801 550.1061349 514.3080254 0.934925086 -0.097077326 0.813114091 1 2.636598379 2.571205115 57683 zinc finger DBF-type containing 2 "GO:0003676,GO:0008270" nucleic acid binding|zinc ion binding ZDHHC1 90.38378332 83.22638941 97.54117724 1.171998184 0.228970334 0.755171631 1 1.584632714 1.937186732 29800 zinc finger DHHC-type containing 1 "GO:0002230,GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006612,GO:0010008,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0032461,GO:0070062,GO:0140374,GO:1905668" positive regulation of defense response to virus by host|DNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein targeting to membrane|endosome membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|positive regulation of protein oligomerization|extracellular exosome|antiviral innate immune response|positive regulation of protein localization to endosome ZDHHC11 33.70410942 47.70293051 19.70528833 0.413083392 -1.275495038 0.184387251 1 0.325560591 0.140276684 79844 zinc finger DHHC-type containing 11 "GO:0002230,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006612,GO:0010008,GO:0016021,GO:0018215,GO:0018230,GO:0019706,GO:0035591,GO:0140374" positive regulation of defense response to virus by host|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein targeting to membrane|endosome membrane|integral component of membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity|signaling adaptor activity|antiviral innate immune response ZDHHC11B 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.013435426 0.004534733 653082 zinc finger DHHC-type containing 11B "GO:0005783,GO:0005794,GO:0006612,GO:0016021,GO:0018215,GO:0018230,GO:0019706" endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|integral component of membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC12 982.4781156 853.5779694 1111.378262 1.302023133 0.380755081 0.281562457 1 32.87506685 44.64792446 84885 zinc finger DHHC-type palmitoyltransferase 12 "GO:0000139,GO:0005783,GO:0005789,GO:0005794,GO:0006612,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0032230,GO:0097116" "Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein targeting to membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|positive regulation of synaptic transmission, GABAergic|gephyrin clustering involved in postsynaptic density assembly" ZDHHC13 459.5486538 398.8776956 520.2196119 1.304208327 0.383174336 0.359389257 1 7.471060697 10.1635438 54503 zinc finger DHHC-type palmitoyltransferase 13 "GO:0000139,GO:0005783,GO:0015095,GO:0016020,GO:0016021,GO:0016409,GO:0018215,GO:0018345,GO:0019706,GO:0030659,GO:0030660,GO:0043123,GO:1903830" Golgi membrane|endoplasmic reticulum|magnesium ion transmembrane transporter activity|membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|cytoplasmic vesicle membrane|Golgi-associated vesicle membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|magnesium ion transmembrane transport ZDHHC14 131.4152712 160.363043 102.4674993 0.638972031 -0.646175311 0.297499124 1 0.875573782 0.583566734 79683 zinc finger DHHC-type palmitoyltransferase 14 "GO:0005783,GO:0005789,GO:0005794,GO:0006612,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0032580" endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein targeting to membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|Golgi cisterna membrane ZDHHC16 3396.220559 3133.169074 3659.272043 1.167914005 0.223934051 0.481572251 1 73.63524847 89.7041536 84287 zinc finger DHHC-type palmitoyltransferase 16 "GO:0001654,GO:0005515,GO:0005789,GO:0005794,GO:0006915,GO:0006974,GO:0007507,GO:0016021,GO:0016409,GO:0018215,GO:0018345,GO:0019706,GO:0021537" eye development|protein binding|endoplasmic reticulum membrane|Golgi apparatus|apoptotic process|cellular response to DNA damage stimulus|heart development|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|telencephalon development ZDHHC17 775.5631856 785.5759195 765.5504517 0.974508552 -0.037253249 0.92325871 1 8.399123702 8.53759525 23390 zinc finger DHHC-type palmitoyltransferase 17 "GO:0000139,GO:0005102,GO:0005515,GO:0005794,GO:0007409,GO:0015095,GO:0016021,GO:0016235,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0030659,GO:0030660,GO:0042734,GO:0042802,GO:0042953,GO:0042995,GO:0043123,GO:0043231,GO:0051386,GO:0070372,GO:1903830" Golgi membrane|signaling receptor binding|protein binding|Golgi apparatus|axonogenesis|magnesium ion transmembrane transporter activity|integral component of membrane|aggresome|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|cytoplasmic vesicle membrane|Golgi-associated vesicle membrane|presynaptic membrane|identical protein binding|lipoprotein transport|cell projection|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|regulation of neurotrophin TRK receptor signaling pathway|regulation of ERK1 and ERK2 cascade|magnesium ion transmembrane transport ZDHHC18 854.9620864 656.6765115 1053.247661 1.603906403 0.681589954 0.060680041 1 6.592338691 11.02895748 84243 zinc finger DHHC-type palmitoyltransferase 18 "GO:0000139,GO:0005783,GO:0005794,GO:0006612,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706" Golgi membrane|endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC2 874.3541296 837.3386739 911.3695853 1.088412149 0.122224965 0.737052086 1 10.54144914 11.96767063 51201 zinc finger DHHC-type palmitoyltransferase 2 "GO:0000139,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0006612,GO:0014069,GO:0016188,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0022407,GO:0042176,GO:0042803,GO:0044267,GO:0048168,GO:0055038,GO:0072659,GO:0098837,GO:1900273,GO:1903076,GO:1903539,GO:1904719,GO:1905751" Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|protein targeting to membrane|postsynaptic density|synaptic vesicle maturation|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|regulation of cell-cell adhesion|regulation of protein catabolic process|protein homodimerization activity|cellular protein metabolic process|regulation of neuronal synaptic plasticity|recycling endosome membrane|protein localization to plasma membrane|postsynaptic recycling endosome|positive regulation of long-term synaptic potentiation|regulation of protein localization to plasma membrane|protein localization to postsynaptic membrane|positive regulation of AMPA glutamate receptor clustering|positive regulation of endosome to plasma membrane protein transport ZDHHC20 2168.670909 2027.882025 2309.459792 1.138853131 0.187581705 0.558963501 1 18.5958846 22.09024293 253832 zinc finger DHHC-type palmitoyltransferase 20 "GO:0005783,GO:0005794,GO:0005886,GO:0006612,GO:0008270,GO:0016020,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0030173,GO:0043231,GO:0048471" endoplasmic reticulum|Golgi apparatus|plasma membrane|protein targeting to membrane|zinc ion binding|membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|integral component of Golgi membrane|intracellular membrane-bounded organelle|perinuclear region of cytoplasm ZDHHC21 446.6011611 456.7301858 436.4721365 0.955645478 -0.065452584 0.881369786 1 2.402552208 2.394890011 340481 zinc finger DHHC-type palmitoyltransferase 21 "GO:0000139,GO:0001942,GO:0003056,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0006612,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0048733,GO:0050999,GO:0071875,GO:1903140,GO:1904997" Golgi membrane|hair follicle development|regulation of vascular associated smooth muscle contraction|protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|protein targeting to membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|sebaceous gland development|regulation of nitric-oxide synthase activity|adrenergic receptor signaling pathway|regulation of establishment of endothelial barrier|regulation of leukocyte adhesion to arterial endothelial cell ZDHHC22 2.463161041 0 4.926322083 Inf Inf 0.189235799 1 0 0.03393953 283576 zinc finger DHHC-type palmitoyltransferase 22 "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006612,GO:0016021,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0072659" Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|protein targeting to membrane|integral component of membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|protein localization to plasma membrane ZDHHC23 161.0622783 166.4527788 155.6717778 0.935230874 -0.096605538 0.877439746 1 1.230872541 1.200736876 254887 zinc finger DHHC-type palmitoyltransferase 23 "GO:0000139,GO:0003674,GO:0005515,GO:0005575,GO:0005783,GO:0005794,GO:0006612,GO:0016021,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0072659" Golgi membrane|molecular_function|protein binding|cellular_component|endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|integral component of membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|protein localization to plasma membrane ZDHHC24 337.0195675 374.5187523 299.5203826 0.799747358 -0.322383774 0.481332545 1 2.228913464 1.859353439 254359 zinc finger DHHC-type containing 24 "GO:0005515,GO:0005783,GO:0005794,GO:0006612,GO:0016021,GO:0018215,GO:0018230,GO:0019706" protein binding|endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|integral component of membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC3 1882.639147 2108.063546 1657.214749 0.786131306 -0.347157792 0.283703421 1 11.67606975 9.574314781 51304 zinc finger DHHC-type palmitoyltransferase 3 "GO:0000139,GO:0005783,GO:0005794,GO:0006612,GO:0008277,GO:0016020,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0032230,GO:0036462,GO:0042803,GO:0044873,GO:0072659,GO:1902685,GO:1903546" "Golgi membrane|endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|regulation of G protein-coupled receptor signaling pathway|membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|positive regulation of synaptic transmission, GABAergic|TRAIL-activated apoptotic signaling pathway|protein homodimerization activity|lipoprotein localization to membrane|protein localization to plasma membrane|positive regulation of receptor localization to synapse|protein localization to photoreceptor outer segment" ZDHHC4 981.820696 1044.389691 919.2517006 0.880180749 -0.184128277 0.603621629 1 26.12081654 23.98140061 55146 zinc finger DHHC-type palmitoyltransferase 4 "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006612,GO:0016021,GO:0018215,GO:0018230,GO:0019706" Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|protein targeting to membrane|integral component of membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC5 3549.249296 3693.424769 3405.073824 0.921928572 -0.117273115 0.712870331 1 38.8976783 37.40562233 25921 zinc finger DHHC-type palmitoyltransferase 5 "GO:0005515,GO:0005886,GO:0016020,GO:0016021,GO:0016409,GO:0018215,GO:0018345,GO:0019706,GO:0030425,GO:0045335,GO:0062208,GO:1903078,GO:1905171" protein binding|plasma membrane|membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|dendrite|phagocytic vesicle|positive regulation of pattern recognition receptor signaling pathway|positive regulation of protein localization to plasma membrane|positive regulation of protein localization to phagocytic vesicle ZDHHC6 649.4899182 653.6316436 645.3481928 0.987327035 -0.018400063 0.966155104 1 8.185988347 8.430398053 64429 zinc finger DHHC-type palmitoyltransferase 6 "GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006612,GO:0010636,GO:0016021,GO:0016409,GO:0016747,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0043543" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein targeting to membrane|positive regulation of mitochondrial fusion|integral component of membrane|palmitoyltransferase activity|transferase activity, transferring acyl groups other than amino-acyl groups|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|protein acylation" ZDHHC7 1190.504995 1199.677955 1181.332035 0.98470763 -0.022232658 0.950834293 1 16.55571013 17.00478114 55625 zinc finger DHHC-type palmitoyltransferase 7 "GO:0000139,GO:0005654,GO:0005783,GO:0005794,GO:0006612,GO:0008277,GO:0009895,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0030859,GO:0044381,GO:0150106,GO:1902044,GO:1903076" Golgi membrane|nucleoplasm|endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|regulation of G protein-coupled receptor signaling pathway|negative regulation of catabolic process|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|polarized epithelial cell differentiation|glucose import in response to insulin stimulus|regulation of protein localization to cell-cell junction|regulation of Fas signaling pathway|regulation of protein localization to plasma membrane ZDHHC8 1832.6757 1723.395234 1941.956165 1.126819969 0.172257036 0.596122826 1 17.28736162 20.31885268 29801 zinc finger DHHC-type palmitoyltransferase 8 "GO:0000139,GO:0005794,GO:0005829,GO:0007626,GO:0010875,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0031966,GO:0034380,GO:1903078" Golgi membrane|Golgi apparatus|cytosol|locomotory behavior|positive regulation of cholesterol efflux|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|mitochondrial membrane|high-density lipoprotein particle assembly|positive regulation of protein localization to plasma membrane ZDHHC9 1414.015519 1324.517539 1503.5135 1.135140499 0.182870874 0.584836737 1 12.49201876 14.79102175 51114 zinc finger DHHC-type palmitoyltransferase 9 "GO:0002178,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006612,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0031228,GO:0043849" palmitoyltransferase complex|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|intrinsic component of Golgi membrane|Ras palmitoyltransferase activity ZEB1 748.8571259 778.4712277 719.2430241 0.923917286 -0.114164395 0.761667539 1 4.808735383 4.634254727 6935 zinc finger E-box binding homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007399,GO:0008270,GO:0019221,GO:0030154,GO:0045602,GO:0045666,GO:0045892,GO:0048856,GO:0070888" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|nervous system development|zinc ion binding|cytokine-mediated signaling pathway|cell differentiation|negative regulation of endothelial cell differentiation|positive regulation of neuron differentiation|negative regulation of transcription, DNA-templated|anatomical structure development|E-box binding" "hsa05202,hsa05206,hsa05215" Transcriptional misregulation in cancer|MicroRNAs in cancer|Prostate cancer Homeobox ZEB2 614.4321216 547.061267 681.8029763 1.246300949 0.317652484 0.414628328 1 2.990472019 3.887573371 9839 zinc finger E-box binding homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0007399,GO:0019208,GO:0043565,GO:0045636,GO:0045944,GO:0046872,GO:0048023,GO:0048066,GO:0048856,GO:0050790,GO:0097324,GO:1903056" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|nervous system development|phosphatase regulator activity|sequence-specific DNA binding|positive regulation of melanocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of melanin biosynthetic process|developmental pigmentation|anatomical structure development|regulation of catalytic activity|melanocyte migration|regulation of melanosome organization" hsa05206 MicroRNAs in cancer ZER1 1415.18586 1067.733679 1762.638041 1.650821807 0.723184402 0.030900671 0.785916967 11.15908875 19.21519777 10444 zyg-11 related cell cycle regulator "GO:0006515,GO:0031462,GO:0032436" protein quality control for misfolded or incompletely synthesized proteins|Cul2-RING ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process ZFAND1 1344.630091 1127.616081 1561.6441 1.384907618 0.469789742 0.162762271 1 25.43865323 36.74775812 79752 zinc finger AN1-type containing 1 "GO:0005515,GO:0008270,GO:0010494,GO:0034599,GO:0034605,GO:0035617,GO:0070628,GO:0071470,GO:0090316,GO:1903843" protein binding|zinc ion binding|cytoplasmic stress granule|cellular response to oxidative stress|cellular response to heat|stress granule disassembly|proteasome binding|cellular response to osmotic stress|positive regulation of intracellular protein transport|cellular response to arsenite ion ZFAND2A 490.4575519 491.2386887 489.676415 0.996819726 -0.004595477 0.996758691 1 5.689345208 5.915546047 90637 zinc finger AN1-type containing 2A "GO:0005515,GO:0005634,GO:0005737,GO:0008270" protein binding|nucleus|cytoplasm|zinc ion binding ZFAND2B 220.8758948 214.1557093 227.5960802 1.062759807 0.087815571 0.874462608 1 9.031000151 10.01121758 130617 zinc finger AN1-type containing 2B "GO:0000502,GO:0005515,GO:0005783,GO:0005789,GO:0006616,GO:0008270,GO:0031225,GO:0036435,GO:0043130,GO:0043161,GO:0043567,GO:0045047" "proteasome complex|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|SRP-dependent cotranslational protein targeting to membrane, translocation|zinc ion binding|anchored component of membrane|K48-linked polyubiquitin modification-dependent protein binding|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of insulin-like growth factor receptor signaling pathway|protein targeting to ER" ZFAND3 1488.107305 1472.70111 1503.5135 1.020922365 0.029873162 0.930330308 1 20.44602956 21.77296788 60685 zinc finger AN1-type containing 3 "GO:0003677,GO:0005515,GO:0008270" DNA binding|protein binding|zinc ion binding ZFAND4 146.3157252 134.9891438 157.6423066 1.167814701 0.223811378 0.715246058 1 1.154852014 1.406747668 93550 zinc finger AN1-type containing 4 GO:0008270 zinc ion binding ZFAND5 2687.248828 2757.635366 2616.86229 0.948951527 -0.0755937 0.813303979 1 16.13872232 15.97456746 7763 zinc finger AN1-type containing 5 "GO:0001701,GO:0001944,GO:0003016,GO:0003674,GO:0003677,GO:0005515,GO:0005575,GO:0005737,GO:0008150,GO:0008270,GO:0010761,GO:0048008,GO:0048705,GO:0048745,GO:0060324" in utero embryonic development|vasculature development|respiratory system process|molecular_function|DNA binding|protein binding|cellular_component|cytoplasm|biological_process|zinc ion binding|fibroblast migration|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|smooth muscle tissue development|face development ZFAND6 1656.787196 1587.391135 1726.183258 1.087434105 0.120927981 0.713191535 1 18.07458655 20.50157617 54469 zinc finger AN1-type containing 6 "GO:0003674,GO:0003677,GO:0005515,GO:0005575,GO:0005829,GO:0006625,GO:0006915,GO:0008270,GO:0031593,GO:0043066,GO:0043122,GO:0071356" molecular_function|DNA binding|protein binding|cellular_component|cytosol|protein targeting to peroxisome|apoptotic process|zinc ion binding|polyubiquitin modification-dependent protein binding|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|cellular response to tumor necrosis factor ZFAT 469.7318644 556.1958707 383.267858 0.689087924 -0.537240019 0.1958433 1 1.423198035 1.022953528 57623 zinc finger and AT-hook domain containing "GO:0000978,GO:0000981,GO:0001228,GO:0002244,GO:0005634,GO:0005829,GO:0006355,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|hematopoietic progenitor cell differentiation|nucleus|cytosol|regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZFC3H1 2070.955787 1780.232769 2361.678806 1.326612367 0.40774688 0.204937515 1 12.81263457 17.7295785 196441 zinc finger C3H1-type containing "GO:0000178,GO:0005515,GO:0005615,GO:0005634,GO:0005730,GO:0006396,GO:0046872" exosome (RNase complex)|protein binding|extracellular space|nucleus|nucleolus|RNA processing|metal ion binding ZFHX2 39.13790949 48.71788648 29.5579325 0.606716232 -0.720906186 0.435826808 1 0.166064685 0.105094219 85446 zinc finger homeobox 2 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0008270,GO:0030534,GO:0045664,GO:0051930" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|zinc ion binding|adult behavior|regulation of neuron differentiation|regulation of sensory perception of pain" ZFHX3 937.5095295 911.4304596 963.5885994 1.057226681 0.080284739 0.824240537 1 2.310000373 2.54739384 463 zinc finger homeobox 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006355,GO:0006357,GO:0007050,GO:0007420,GO:0007517,GO:0008270,GO:0016604,GO:0019899,GO:0032922,GO:0045664,GO:0045785,GO:0045893,GO:0045944,GO:0071559,GO:1904059" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle arrest|brain development|muscle organ development|zinc ion binding|nuclear body|enzyme binding|circadian regulation of gene expression|regulation of neuron differentiation|positive regulation of cell adhesion|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|response to transforming growth factor beta|regulation of locomotor rhythm" hsa04550 Signaling pathways regulating pluripotency of stem cells Homeobox ZFHX4 1502.995635 1412.818708 1593.172562 1.127655341 0.173326186 0.601775666 1 4.965943746 5.841092804 79776 zinc finger homeobox 4 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding" ZFP1 256.2684633 242.5744764 269.9624501 1.112905422 0.154330994 0.76200846 1 2.87784996 3.340737375 162239 ZFP1 zinc finger protein "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZFP14 158.7354509 142.0938356 175.3770661 1.234234163 0.303616133 0.606481357 1 0.916291252 1.179633326 57677 ZFP14 zinc finger protein "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZFP2 2.985484801 2.029911937 3.941057666 1.941491941 0.957165719 0.808083103 1 0.042658871 0.086389483 80108 ZFP2 zinc finger protein "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZFP30 273.8668892 266.9334197 280.8003587 1.051949055 0.073064839 0.88785959 1 2.132035329 2.339402958 22835 ZFP30 zinc finger protein "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZFP36 137.017818 105.5554207 168.4802152 1.596130394 0.674578515 0.270132603 1 3.060108576 5.094729533 7538 ZFP36 ring finger protein "GO:0000122,GO:0000165,GO:0000178,GO:0000288,GO:0000289,GO:0000932,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006402,GO:0009611,GO:0010494,GO:0010837,GO:0016032,GO:0019899,GO:0019901,GO:0019957,GO:0030014,GO:0031072,GO:0031086,GO:0032680,GO:0032703,GO:0032897,GO:0035278,GO:0035925,GO:0038066,GO:0042594,GO:0043488,GO:0044344,GO:0044877,GO:0045600,GO:0045616,GO:0045647,GO:0046872,GO:0051028,GO:0060213,GO:0061158,GO:0070063,GO:0070578,GO:0070935,GO:0071222,GO:0071356,GO:0071364,GO:0071385,GO:0071889,GO:0097011,GO:1900153,GO:1901835,GO:1902172,GO:1904246,GO:1904582,GO:1990904,GO:2000637" "negative regulation of transcription by RNA polymerase II|MAPK cascade|exosome (RNase complex)|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|P-body|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA catabolic process|response to wounding|cytoplasmic stress granule|regulation of keratinocyte proliferation|viral process|enzyme binding|protein kinase binding|C-C chemokine binding|CCR4-NOT complex|heat shock protein binding|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay|regulation of tumor necrosis factor production|negative regulation of interleukin-2 production|negative regulation of viral transcription|miRNA mediated inhibition of translation|mRNA 3'-UTR AU-rich region binding|p38MAPK cascade|response to starvation|regulation of mRNA stability|cellular response to fibroblast growth factor stimulus|protein-containing complex binding|positive regulation of fat cell differentiation|regulation of keratinocyte differentiation|negative regulation of erythrocyte differentiation|metal ion binding|mRNA transport|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|3'-UTR-mediated mRNA destabilization|RNA polymerase binding|RISC-loading complex|3'-UTR-mediated mRNA stabilization|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to glucocorticoid stimulus|14-3-3 protein binding|cellular response to granulocyte macrophage colony-stimulating factor stimulus|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA|regulation of keratinocyte apoptotic process|negative regulation of polynucleotide adenylyltransferase activity|positive regulation of intracellular mRNA localization|ribonucleoprotein complex|positive regulation of gene silencing by miRNA" "hsa05166,hsa05167" Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection ZFP36L1 3900.849392 4121.736188 3679.962596 0.892818567 -0.163561065 0.607886575 1 65.37782565 60.88490258 677 ZFP36 ring finger protein like 1 "GO:0000165,GO:0000288,GO:0000932,GO:0001570,GO:0003342,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006397,GO:0006915,GO:0007507,GO:0008283,GO:0009611,GO:0010468,GO:0010837,GO:0014065,GO:0021915,GO:0031086,GO:0031440,GO:0032869,GO:0033077,GO:0035264,GO:0035925,GO:0038066,GO:0043488,GO:0043491,GO:0044344,GO:0045577,GO:0045600,GO:0045616,GO:0045647,GO:0045657,GO:0045661,GO:0046872,GO:0048382,GO:0051028,GO:0060710,GO:0061158,GO:0070371,GO:0071320,GO:0071356,GO:0071364,GO:0071375,GO:0071385,GO:0071456,GO:0071472,GO:0071560,GO:0071889,GO:0072091,GO:0097403,GO:1900153,GO:1901991,GO:1902172,GO:1904582,GO:1990904" "MAPK cascade|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|P-body|vasculogenesis|proepicardium development|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA processing|apoptotic process|heart development|cell population proliferation|response to wounding|regulation of gene expression|regulation of keratinocyte proliferation|phosphatidylinositol 3-kinase signaling|neural tube development|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay|regulation of mRNA 3'-end processing|cellular response to insulin stimulus|T cell differentiation in thymus|multicellular organism growth|mRNA 3'-UTR AU-rich region binding|p38MAPK cascade|regulation of mRNA stability|protein kinase B signaling|cellular response to fibroblast growth factor stimulus|regulation of B cell differentiation|positive regulation of fat cell differentiation|regulation of keratinocyte differentiation|negative regulation of erythrocyte differentiation|positive regulation of monocyte differentiation|regulation of myoblast differentiation|metal ion binding|mesendoderm development|mRNA transport|chorio-allantoic fusion|3'-UTR-mediated mRNA destabilization|ERK1 and ERK2 cascade|cellular response to cAMP|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to peptide hormone stimulus|cellular response to glucocorticoid stimulus|cellular response to hypoxia|cellular response to salt stress|cellular response to transforming growth factor beta stimulus|14-3-3 protein binding|regulation of stem cell proliferation|cellular response to raffinose|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of mitotic cell cycle phase transition|regulation of keratinocyte apoptotic process|positive regulation of intracellular mRNA localization|ribonucleoprotein complex" hsa04218 Cellular senescence ZFP36L2 870.9408389 772.3814919 969.5001859 1.255208982 0.327927581 0.364448428 1 10.59257995 13.86863501 678 ZFP36 ring finger protein like 2 "GO:0000288,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0006402,GO:0009611,GO:0030097,GO:0033077,GO:0035019,GO:0035925,GO:0043488,GO:0044344,GO:0045577,GO:0045599,GO:0046872,GO:0048103,GO:0060216,GO:0061158,GO:0070371,GO:0071356,GO:0071364,GO:0071385,GO:0071560,GO:0097011,GO:1900153,GO:1901991,GO:2000737" "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|RNA binding|protein binding|nucleus|cytoplasm|mRNA catabolic process|response to wounding|hemopoiesis|T cell differentiation in thymus|somatic stem cell population maintenance|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|cellular response to fibroblast growth factor stimulus|regulation of B cell differentiation|negative regulation of fat cell differentiation|metal ion binding|somatic stem cell division|definitive hemopoiesis|3'-UTR-mediated mRNA destabilization|ERK1 and ERK2 cascade|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to glucocorticoid stimulus|cellular response to transforming growth factor beta stimulus|cellular response to granulocyte macrophage colony-stimulating factor stimulus|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of mitotic cell cycle phase transition|negative regulation of stem cell differentiation" hsa04218 Cellular senescence ZFP37 117.730933 100.4806409 134.9812251 1.343355535 0.425841182 0.511283094 1 0.804965199 1.127934819 7539 ZFP37 zinc finger protein "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection ZFP41 825.0194015 798.7703471 851.2684559 1.065723658 0.091833395 0.804028218 1 6.635214071 7.375907732 286128 ZFP41 zinc finger protein "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0007275,GO:0007283,GO:0030154,GO:0046872,GO:1990837" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|cell differentiation|metal ion binding|sequence-specific double-stranded DNA binding" ZFP62 341.3938743 370.4589285 312.32882 0.843086226 -0.246247905 0.590519076 1 2.707422486 2.380915353 643836 ZFP62 zinc finger protein "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZFP64 1547.378309 1584.346267 1510.410351 0.953333487 -0.068947122 0.836247688 1 15.08583365 15.00134132 55734 ZFP64 zinc finger protein "GO:0003677,GO:0005515,GO:0005634,GO:0010468,GO:0045944,GO:0046872" DNA binding|protein binding|nucleus|regulation of gene expression|positive regulation of transcription by RNA polymerase II|metal ion binding zf-C2H2 ZFP69 128.1949755 108.6002886 147.7896625 1.360858837 0.444517423 0.479670199 1 1.903849602 2.702474751 339559 ZFP69 zinc finger protein "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0006629,GO:0019216,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|lipid metabolic process|regulation of lipid metabolic process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZFP69B 190.0209366 192.841634 187.2002391 0.970745971 -0.042834281 0.947895619 1 4.188142563 4.240753046 65243 ZFP69 zinc finger protein B "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005730,GO:0006357,GO:0007030,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleolus|regulation of transcription by RNA polymerase II|Golgi organization|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZFP82 241.2613672 294.3372308 188.1855036 0.639353381 -0.645314543 0.203550086 1 2.047684393 1.365588704 284406 ZFP82 zinc finger protein "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZFP90 648.9542325 448.610538 849.2979271 1.893174268 0.920807218 0.017065125 0.570200991 4.243657293 8.380054187 146198 ZFP90 zinc finger protein "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0043392,GO:0045893,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|negative regulation of DNA binding|positive regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZFP91 3460.180106 3599.033864 3321.326348 0.922838315 -0.11585019 0.716177577 1 31.5578893 30.37732278 80829 "ZFP91 zinc finger protein, atypical E3 ubiquitin ligase" "GO:0004842,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0007250,GO:0046872,GO:0070534" ubiquitin-protein transferase activity|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|activation of NF-kappaB-inducing kinase activity|metal ion binding|protein K63-linked ubiquitination ZFPL1 646.1157217 658.7064235 633.5250198 0.961771431 -0.056234022 0.887507596 1 24.13976597 24.21702877 7542 zinc finger protein like 1 "GO:0003677,GO:0005515,GO:0005634,GO:0005794,GO:0006355,GO:0008270,GO:0016021,GO:0016192" "DNA binding|protein binding|nucleus|Golgi apparatus|regulation of transcription, DNA-templated|zinc ion binding|integral component of membrane|vesicle-mediated transport" ZFPM1 106.0265262 108.6002886 103.4527637 0.952601186 -0.07005575 0.930685094 1 0.692112936 0.687707901 161882 "zinc finger protein, FOG family member 1" "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001102,GO:0002295,GO:0003151,GO:0003181,GO:0003192,GO:0003195,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0007507,GO:0007596,GO:0008134,GO:0010724,GO:0017053,GO:0030154,GO:0030218,GO:0030219,GO:0030220,GO:0030851,GO:0032091,GO:0032642,GO:0032713,GO:0032729,GO:0035162,GO:0035855,GO:0045599,GO:0045652,GO:0045944,GO:0046872,GO:0055008,GO:0060318,GO:0060319,GO:0060377,GO:0060412,GO:0060413,GO:0071733" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|T-helper cell lineage commitment|outflow tract morphogenesis|atrioventricular valve morphogenesis|mitral valve formation|tricuspid valve formation|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|heart development|blood coagulation|transcription factor binding|regulation of definitive erythrocyte differentiation|transcription repressor complex|cell differentiation|erythrocyte differentiation|megakaryocyte differentiation|platelet formation|granulocyte differentiation|negative regulation of protein binding|regulation of chemokine production|negative regulation of interleukin-4 production|positive regulation of interferon-gamma production|embryonic hemopoiesis|megakaryocyte development|negative regulation of fat cell differentiation|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|cardiac muscle tissue morphogenesis|definitive erythrocyte differentiation|primitive erythrocyte differentiation|negative regulation of mast cell differentiation|ventricular septum morphogenesis|atrial septum morphogenesis|transcriptional activation by promoter-enhancer looping" ZFPM2 35.88520072 28.41876711 43.35163433 1.525457954 0.609242415 0.525589373 1 0.118169975 0.188028342 23414 "zinc finger protein, FOG family member 2" "GO:0000122,GO:0000785,GO:0001085,GO:0001570,GO:0001701,GO:0003148,GO:0003221,GO:0003677,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007506,GO:0007507,GO:0007596,GO:0008134,GO:0008270,GO:0030154,GO:0030324,GO:0045599,GO:0045892,GO:0045944,GO:0048568,GO:0060045,GO:0060412,GO:0060548,GO:2000020,GO:2000195" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription factor binding|vasculogenesis|in utero embryonic development|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|gonadal mesoderm development|heart development|blood coagulation|transcription factor binding|zinc ion binding|cell differentiation|lung development|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic organ development|positive regulation of cardiac muscle cell proliferation|ventricular septum morphogenesis|negative regulation of cell death|positive regulation of male gonad development|negative regulation of female gonad development" hsa05206 MicroRNAs in cancer ZFR 2501.287469 2943.372308 2059.202631 0.699606579 -0.515384239 0.106673028 1 31.60301544 23.06207275 51663 zinc finger RNA binding protein "GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0005515,GO:0005634,GO:0005694,GO:0005737,GO:0007275,GO:0008270" DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|protein binding|nucleus|chromosome|cytoplasm|multicellular organism development|zinc ion binding ZFTA 858.7207893 879.9668246 837.4747541 0.951711736 -0.071403433 0.846540638 1 7.982664397 7.924451756 65998 zinc finger translocation associated ZFX 1141.989506 1183.438659 1100.540353 0.929951329 -0.104772884 0.762920989 1 5.566731045 5.399784003 7543 zinc finger protein X-linked "GO:0001541,GO:0005654,GO:0005694,GO:0005730,GO:0006357,GO:0007283,GO:0009566,GO:0009791,GO:0035264,GO:0043035,GO:0046872,GO:0048599,GO:0048872,GO:0060746" ovarian follicle development|nucleoplasm|chromosome|nucleolus|regulation of transcription by RNA polymerase II|spermatogenesis|fertilization|post-embryonic development|multicellular organism growth|chromatin insulator sequence binding|metal ion binding|oocyte development|homeostasis of number of cells|parental behavior zf-C2H2 ZFYVE1 651.0771785 593.7492415 708.4051155 1.193104877 0.254720865 0.507952768 1 6.232394707 7.756208954 53349 zinc finger FYVE-type containing 1 "GO:0000407,GO:0005515,GO:0005545,GO:0005547,GO:0005739,GO:0005776,GO:0005783,GO:0005789,GO:0005794,GO:0005795,GO:0005811,GO:0008270,GO:0009267,GO:0010923,GO:0016020,GO:0016236,GO:0032266,GO:0043325,GO:0044233,GO:0048471,GO:0097629,GO:0140042,GO:1990462" "phagophore assembly site|protein binding|1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|mitochondrion|autophagosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|Golgi stack|lipid droplet|zinc ion binding|cellular response to starvation|negative regulation of phosphatase activity|membrane|macroautophagy|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-3,4-bisphosphate binding|mitochondria-associated endoplasmic reticulum membrane|perinuclear region of cytoplasm|extrinsic component of omegasome membrane|lipid droplet formation|omegasome" "hsa04140,hsa05022" Autophagy - animal|Pathways of neurodegeneration - multiple diseases ZFYVE16 1201.615571 1150.960068 1252.271073 1.088023041 0.121709109 0.723407658 1 5.682595741 6.449124836 9765 zinc finger FYVE-type containing 16 "GO:0005515,GO:0005545,GO:0005547,GO:0005769,GO:0005829,GO:0006622,GO:0007165,GO:0016050,GO:0016197,GO:0030100,GO:0030509,GO:0031901,GO:0043231,GO:0046872" "protein binding|1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|early endosome|cytosol|protein targeting to lysosome|signal transduction|vesicle organization|endosomal transport|regulation of endocytosis|BMP signaling pathway|early endosome membrane|intracellular membrane-bounded organelle|metal ion binding" "hsa04144,hsa04350" Endocytosis|TGF-beta signaling pathway ZFYVE19 706.9200457 639.4222601 774.4178314 1.211121163 0.276343203 0.464247875 1 13.1058202 16.55646931 84936 zinc finger FYVE-type containing 19 "GO:0005515,GO:0005737,GO:0005813,GO:0009838,GO:0030496,GO:0032154,GO:0032266,GO:0032466,GO:0044878,GO:0046872,GO:0051301,GO:0090543" protein binding|cytoplasm|centrosome|abscission|midbody|cleavage furrow|phosphatidylinositol-3-phosphate binding|negative regulation of cytokinesis|mitotic cytokinesis checkpoint|metal ion binding|cell division|Flemming body ZFYVE21 614.3727385 543.0014431 685.7440339 1.262877001 0.336714133 0.387067956 1 19.13786186 25.209858 79038 zinc finger FYVE-type containing 21 "GO:0005515,GO:0005768,GO:0005925,GO:0046872" protein binding|endosome|focal adhesion|metal ion binding ZFYVE26 1519.904474 1288.99408 1750.814868 1.358279992 0.441780903 0.182193941 1 6.030205325 8.543529688 23503 zinc finger FYVE-type containing 26 "GO:0000281,GO:0000724,GO:0005515,GO:0005765,GO:0005813,GO:0030496,GO:0032266,GO:0032465,GO:0046872" mitotic cytokinesis|double-strand break repair via homologous recombination|protein binding|lysosomal membrane|centrosome|midbody|phosphatidylinositol-3-phosphate binding|regulation of cytokinesis|metal ion binding ZFYVE27 1767.574019 1718.320454 1816.827584 1.057327566 0.080422401 0.80621159 1 14.69800188 16.21002869 118813 zinc finger FYVE-type containing 27 "GO:0005515,GO:0005654,GO:0005783,GO:0005829,GO:0016192,GO:0030176,GO:0030424,GO:0030425,GO:0031175,GO:0032584,GO:0042802,GO:0043231,GO:0043621,GO:0045773,GO:0046872,GO:0048011,GO:0055038,GO:0071782,GO:0071787,GO:0072659" protein binding|nucleoplasm|endoplasmic reticulum|cytosol|vesicle-mediated transport|integral component of endoplasmic reticulum membrane|axon|dendrite|neuron projection development|growth cone membrane|identical protein binding|intracellular membrane-bounded organelle|protein self-association|positive regulation of axon extension|metal ion binding|neurotrophin TRK receptor signaling pathway|recycling endosome membrane|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network formation|protein localization to plasma membrane hsa04144 Endocytosis ZFYVE28 139.6564067 151.2284393 128.0843742 0.846959572 -0.239634989 0.70002056 1 0.56247242 0.49691241 57732 zinc finger FYVE-type containing 28 "GO:0005515,GO:0005829,GO:0007175,GO:0031901,GO:0032266,GO:0042059,GO:0046872" protein binding|cytosol|negative regulation of epidermal growth factor-activated receptor activity|early endosome membrane|phosphatidylinositol-3-phosphate binding|negative regulation of epidermal growth factor receptor signaling pathway|metal ion binding ZFYVE9 902.7283594 891.1313402 914.3253786 1.026027632 0.037069584 0.920843097 1 5.795153911 6.202117093 9372 zinc finger FYVE-type containing 9 "GO:0005515,GO:0005545,GO:0005769,GO:0005829,GO:0006897,GO:0007179,GO:0016197,GO:0019904,GO:0031901,GO:0032991,GO:0043231,GO:0046872" protein binding|1-phosphatidylinositol binding|early endosome|cytosol|endocytosis|transforming growth factor beta receptor signaling pathway|endosomal transport|protein domain specific binding|early endosome membrane|protein-containing complex|intracellular membrane-bounded organelle|metal ion binding "hsa04144,hsa04350" Endocytosis|TGF-beta signaling pathway ZGLP1 26.03255656 28.41876711 23.646346 0.832067975 -0.265226703 0.827971702 1 0.726924393 0.630905015 100125288 zinc finger GATA like protein 1 "GO:0000122,GO:0005634,GO:0006357,GO:0007275,GO:0007283,GO:0008270,GO:0043565,GO:0045944,GO:0048599" negative regulation of transcription by RNA polymerase II|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|zinc ion binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|oocyte development ZGPAT 764.2232422 717.5738696 810.8726148 1.130019708 0.176347934 0.636040255 1 17.77143523 20.94712627 84619 zinc finger CCCH-type and G-patch domain containing "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006357,GO:0007175,GO:0043565,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|plasma membrane|regulation of transcription by RNA polymerase II|negative regulation of epidermal growth factor-activated receptor activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding" ZGRF1 313.3841079 240.5445645 386.2236513 1.605622027 0.683132314 0.143533927 1 1.71226052 2.867669455 55345 zinc finger GRF-type containing 1 "GO:0003723,GO:0004386,GO:0005737,GO:0008270,GO:0016021,GO:0017108,GO:0071932" RNA binding|helicase activity|cytoplasm|zinc ion binding|integral component of membrane|5'-flap endonuclease activity|replication fork reversal ZHX1 847.0972924 994.656849 699.5377357 0.70329555 -0.507797006 0.162342268 1 10.08727682 7.399932165 11244 zinc fingers and homeoboxes 1 "GO:0000122,GO:0000785,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030154,GO:0045892,GO:0046872,GO:0046982" "negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell differentiation|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity" ZHX1-C8orf76 12.98658673 12.17947162 13.79370183 1.132536966 0.17955814 0.952676516 1 0.46589673 0.550374088 100533106 ZHX1-C8orf76 readthrough GO:0005515 protein binding ZHX2 498.7162548 449.625494 547.8070156 1.218362888 0.284943903 0.487140964 1 4.235852881 5.383112541 22882 zinc fingers and homeoboxes 2 "GO:0000122,GO:0000785,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006402,GO:0035019,GO:0042802,GO:0042803,GO:0045665,GO:0045892,GO:0046872,GO:0046982,GO:0060040" "negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|mRNA catabolic process|somatic stem cell population maintenance|identical protein binding|protein homodimerization activity|negative regulation of neuron differentiation|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity|retinal bipolar neuron differentiation" ZHX3 2475.53995 2530.285229 2420.794671 0.956727978 -0.063819306 0.842520031 1 10.06361085 10.0428792 23051 zinc fingers and homeoboxes 3 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030154,GO:0042803,GO:0045669,GO:0045892,GO:0046872,GO:0046982" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell differentiation|protein homodimerization activity|positive regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity" ZIC2 258.072967 264.9035077 251.2424262 0.948429971 -0.076386841 0.885060195 1 4.527987899 4.479468189 7546 Zic family member 2 "GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007417,GO:0007420,GO:0007601,GO:0016604,GO:0030154,GO:0031490,GO:0045892,GO:0045893,GO:0046872,GO:0051091" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|central nervous system development|brain development|visual perception|nuclear body|cell differentiation|chromatin DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|positive regulation of DNA-binding transcription factor activity" ZIC5 48.99055365 48.71788648 49.26322083 1.011193719 0.016059408 1 1 0.548674468 0.578715407 85416 Zic family member 5 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0007417,GO:0030154,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|cell differentiation|metal ion binding|sequence-specific double-stranded DNA binding" ZIK1 159.0202422 127.884452 190.1560324 1.486936288 0.572342833 0.325822771 1 1.130151168 1.752850305 284307 zinc finger protein interacting with K protein 1 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZKSCAN1 1929.919715 2073.555043 1786.284387 0.861459836 -0.21514456 0.505832053 1 9.811121813 8.815960417 7586 zinc finger with KRAB and SCAN domains 1 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZKSCAN2 285.4349624 283.1727152 287.6972096 1.015977862 0.022868966 0.970061723 1 1.902082102 2.015716419 342357 zinc finger with KRAB and SCAN domains 2 "GO:0000978,GO:0000981,GO:0003674,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZKSCAN3 109.3413397 99.4656849 119.2169944 1.198574106 0.261319112 0.699823092 1 0.910461964 1.138263023 80317 zinc finger with KRAB and SCAN domains 3 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006914,GO:0007040,GO:0010507,GO:0043565,GO:0045892,GO:0045893,GO:0046872,GO:2000773" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|autophagy|lysosome organization|negative regulation of autophagy|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of cellular senescence" ZKSCAN4 124.3429925 114.6900244 133.9959607 1.168331434 0.224449598 0.730387692 1 0.915612411 1.115818768 387032 zinc finger with KRAB and SCAN domains 4 "GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0006357,GO:0042802,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding" ZKSCAN5 716.9872117 755.1272405 678.847183 0.898983836 -0.15363292 0.684730788 1 7.681167062 7.202694978 23660 zinc finger with KRAB and SCAN domains 5 "GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" ZKSCAN7 34.07797542 39.58328277 28.57266808 0.721836747 -0.470255505 0.636416315 1 0.505357608 0.38049918 55888 zinc finger with KRAB and SCAN domains 7 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZKSCAN8 1251.074508 1130.660949 1371.488068 1.21299676 0.278575697 0.412760175 1 7.369882667 9.324727398 7745 zinc finger with KRAB and SCAN domains 8 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZMAT2 1395.329146 1461.536594 1329.121698 0.909400218 -0.137012745 0.683354953 1 47.94149774 45.4760339 153527 zinc finger matrin-type 2 "GO:0000398,GO:0003677,GO:0005515,GO:0005634,GO:0008270,GO:0046540,GO:0071005" "mRNA splicing, via spliceosome|DNA binding|protein binding|nucleus|zinc ion binding|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome" hsa03040 Spliceosome ZMAT3 331.4224639 362.3392807 300.505647 0.829348798 -0.269949113 0.558397787 1 1.948524773 1.685617693 64393 zinc finger matrin-type 3 "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005886,GO:0006915,GO:0006974,GO:0008270,GO:0015031,GO:0040008" RNA binding|protein binding|nucleoplasm|nucleolus|plasma membrane|apoptotic process|cellular response to DNA damage stimulus|zinc ion binding|protein transport|regulation of growth hsa04115 p53 signaling pathway ZMAT5 303.5854036 311.5914823 295.579325 0.948611698 -0.076110436 0.878206301 1 14.88774467 14.7310369 55954 zinc finger matrin-type 5 "GO:0000398,GO:0005515,GO:0005654,GO:0005689,GO:0008270,GO:0008380" "mRNA splicing, via spliceosome|protein binding|nucleoplasm|U12-type spliceosomal complex|zinc ion binding|RNA splicing" ZMIZ1 2640.935957 2824.62246 2457.249455 0.869939077 -0.201013725 0.528456744 1 14.87854009 13.50097361 57178 zinc finger MIZ-type containing 1 "GO:0001570,GO:0001701,GO:0003007,GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007179,GO:0007296,GO:0007569,GO:0008270,GO:0021852,GO:0030374,GO:0030521,GO:0033233,GO:0045582,GO:0045747,GO:0045944,GO:0046332,GO:0048096,GO:0048146,GO:0048589,GO:0048844,GO:0060395,GO:1903508" vasculogenesis|in utero embryonic development|heart morphogenesis|transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|vitellogenesis|cell aging|zinc ion binding|pyramidal neuron migration|nuclear receptor coactivator activity|androgen receptor signaling pathway|regulation of protein sumoylation|positive regulation of T cell differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|SMAD binding|chromatin-mediated maintenance of transcription|positive regulation of fibroblast proliferation|developmental growth|artery morphogenesis|SMAD protein signal transduction|positive regulation of nucleic acid-templated transcription zf-MIZ ZMIZ2 1536.506503 1817.786139 1255.226867 0.690525051 -0.534234341 0.106423966 1 13.36010088 9.622880796 83637 zinc finger MIZ-type containing 2 "GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0007179,GO:0008270,GO:0030374,GO:0043596,GO:0045944,GO:0048096,GO:0060395" protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|zinc ion binding|nuclear receptor coactivator activity|nuclear replication fork|positive regulation of transcription by RNA polymerase II|chromatin-mediated maintenance of transcription|SMAD protein signal transduction ZMPSTE24 1646.983049 1725.425146 1568.540951 0.90907505 -0.137528692 0.675864282 1 29.37367957 27.85313097 10269 zinc metallopeptidase STE24 "GO:0001889,GO:0001942,GO:0003007,GO:0003229,GO:0003231,GO:0003417,GO:0003690,GO:0004222,GO:0005515,GO:0005637,GO:0006281,GO:0006508,GO:0006925,GO:0006998,GO:0007628,GO:0008235,GO:0008340,GO:0008360,GO:0010506,GO:0010906,GO:0016020,GO:0019216,GO:0030176,GO:0030282,GO:0030327,GO:0030500,GO:0032006,GO:0032350,GO:0032991,GO:0035264,GO:0040014,GO:0043007,GO:0043516,GO:0043979,GO:0044029,GO:0044255,GO:0046872,GO:0048145,GO:0048538,GO:0048739,GO:0050688,GO:0050905,GO:0060307,GO:0060993,GO:0061337,GO:0061762,GO:0070062,GO:0070302,GO:0071480,GO:0071586,GO:0072423,GO:1903025,GO:1903463,GO:1903799,GO:1990036,GO:1990164,GO:2000618,GO:2000730,GO:2000772" "liver development|hair follicle development|heart morphogenesis|ventricular cardiac muscle tissue development|cardiac ventricle development|growth plate cartilage development|double-stranded DNA binding|metalloendopeptidase activity|protein binding|nuclear inner membrane|DNA repair|proteolysis|inflammatory cell apoptotic process|nuclear envelope organization|adult walking behavior|metalloexopeptidase activity|determination of adult lifespan|regulation of cell shape|regulation of autophagy|regulation of glucose metabolic process|membrane|regulation of lipid metabolic process|integral component of endoplasmic reticulum membrane|bone mineralization|prenylated protein catabolic process|regulation of bone mineralization|regulation of TOR signaling|regulation of hormone metabolic process|protein-containing complex|multicellular organism growth|regulation of multicellular organism growth|maintenance of rDNA|regulation of DNA damage response, signal transduction by p53 class mediator|histone H2B-K5 acetylation|hypomethylation of CpG island|cellular lipid metabolic process|metal ion binding|regulation of fibroblast proliferation|thymus development|cardiac muscle fiber development|regulation of defense response to virus|neuromuscular process|regulation of ventricular cardiac muscle cell membrane repolarization|kidney morphogenesis|cardiac conduction|CAMKK-AMPK signaling cascade|extracellular exosome|regulation of stress-activated protein kinase signaling cascade|cellular response to gamma radiation|CAAX-box protein processing|response to DNA damage checkpoint signaling|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|regulation of mitotic cell cycle DNA replication|negative regulation of production of miRNAs involved in gene silencing by miRNA|calcium ion import into sarcoplasmic reticulum|histone H2A phosphorylation|regulation of histone H4-K16 acetylation|regulation of termination of RNA polymerase I transcription|regulation of cellular senescence" hsa00900 Terpenoid backbone biosynthesis ZMYM1 404.3320307 362.3392807 446.3247807 1.231786904 0.300752695 0.488183742 1 3.471662185 4.460555743 79830 zinc finger MYM-type containing 1 "GO:0005634,GO:0008270,GO:0046983" nucleus|zinc ion binding|protein dimerization activity ZMYM2 1035.493358 975.3726856 1095.614031 1.123277335 0.167714171 0.633342164 1 3.457631806 4.051181217 7750 zinc finger MYM-type containing 2 "GO:0005515,GO:0005829,GO:0008150,GO:0008270,GO:0016605,GO:0031624" protein binding|cytosol|biological_process|zinc ion binding|PML body|ubiquitin conjugating enzyme binding ZMYM3 2179.948747 2125.317798 2234.579697 1.051409676 0.072324917 0.822617409 1 17.90714503 19.63876847 9203 zinc finger MYM-type containing 3 "GO:0003677,GO:0005515,GO:0005654,GO:0007010,GO:0007275,GO:0008270,GO:0022604" DNA binding|protein binding|nucleoplasm|cytoskeleton organization|multicellular organism development|zinc ion binding|regulation of cell morphogenesis other ZMYM4 1989.242183 1919.281736 2059.202631 1.072902738 0.101519298 0.753829129 1 14.06320155 15.73839658 9202 zinc finger MYM-type containing 4 "GO:0003677,GO:0005515,GO:0007010,GO:0007275,GO:0008270,GO:0022604" DNA binding|protein binding|cytoskeleton organization|multicellular organism development|zinc ion binding|regulation of cell morphogenesis ZMYM5 171.3036343 159.348087 183.2591815 1.150055736 0.201703781 0.728915582 1 2.01962424 2.422732094 9205 zinc finger MYM-type containing 5 "GO:0000122,GO:0005515,GO:0005634,GO:0008270" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|zinc ion binding ZMYM6 283.5413841 254.7539481 312.32882 1.226001883 0.293961195 0.544039161 1 2.519013813 3.221347793 9204 zinc finger MYM-type containing 6 "GO:0003677,GO:0005634,GO:0007010,GO:0007275,GO:0008270,GO:0022604" DNA binding|nucleus|cytoskeleton organization|multicellular organism development|zinc ion binding|regulation of cell morphogenesis ZMYND10 20.04674118 23.34398727 16.74949508 0.717507891 -0.478933396 0.69383534 1 0.665704168 0.498223132 51364 zinc finger MYND-type containing 10 "GO:0003341,GO:0005515,GO:0005737,GO:0006457,GO:0016324,GO:0034451,GO:0036158,GO:0036159,GO:0044183,GO:0044458,GO:0046872,GO:0060090,GO:0061512,GO:1905505" cilium movement|protein binding|cytoplasm|protein folding|apical plasma membrane|centriolar satellite|outer dynein arm assembly|inner dynein arm assembly|protein folding chaperone|motile cilium assembly|metal ion binding|molecular adaptor activity|protein localization to cilium|positive regulation of motile cilium assembly ZMYND11 1475.081624 1390.489677 1559.673571 1.121672169 0.165651081 0.618887916 1 13.04861901 15.26674405 10771 zinc finger MYND-type containing 11 "GO:0003690,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006325,GO:0007049,GO:0008270,GO:0016032,GO:0034243,GO:0035064,GO:0043124,GO:0045892,GO:0046329,GO:0051607,GO:2001237" "double-stranded DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|chromosome|chromatin organization|cell cycle|zinc ion binding|viral process|regulation of transcription elongation from RNA polymerase II promoter|methylated histone binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of transcription, DNA-templated|negative regulation of JNK cascade|defense response to virus|negative regulation of extrinsic apoptotic signaling pathway" ZMYND15 3.015176353 4.059823873 1.970528833 0.485372985 -1.042834281 0.770333209 1 0.078270178 0.039626695 84225 zinc finger MYND-type containing 15 "GO:0005634,GO:0005737,GO:0007286,GO:0042826,GO:0045892,GO:0046872" "nucleus|cytoplasm|spermatid development|histone deacetylase binding|negative regulation of transcription, DNA-templated|metal ion binding" ZMYND19 582.5891774 559.2407386 605.9376162 1.083500493 0.11569981 0.772034055 1 11.10292847 12.54823331 116225 zinc finger MYND-type containing 19 "GO:0005515,GO:0005737,GO:0005886,GO:0045202,GO:0046872" protein binding|cytoplasm|plasma membrane|synapse|metal ion binding ZMYND8 2458.484883 3351.384608 1565.585158 0.467145774 -1.098055277 0.00066111 0.071665278 26.52951038 12.92699525 23613 zinc finger MYND-type containing 8 "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0008270,GO:0019904,GO:0030336,GO:0035064,GO:0043197,GO:0043198,GO:0045892,GO:0047485,GO:0051491,GO:0060999,GO:0070491,GO:0070577,GO:0098815,GO:1902897,GO:1902952" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|zinc ion binding|protein domain specific binding|negative regulation of cell migration|methylated histone binding|dendritic spine|dendritic shaft|negative regulation of transcription, DNA-templated|protein N-terminus binding|positive regulation of filopodium assembly|positive regulation of dendritic spine development|repressing transcription factor binding|lysine-acetylated histone binding|modulation of excitatory postsynaptic potential|regulation of postsynaptic density protein 95 clustering|positive regulation of dendritic spine maintenance" ZNF10 188.5430399 192.841634 184.2444459 0.955418403 -0.06579543 0.91435623 1 2.216692796 2.209098301 7556 zinc finger protein 10 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0032991,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|protein-containing complex|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF100 196.113394 171.5275587 220.6992293 1.286669215 0.363641205 0.505452114 1 1.526491958 2.04869525 163227 zinc finger protein 100 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF101 116.0424739 119.7648043 112.3201435 0.937839327 -0.092587316 0.898879115 1 2.38805702 2.336087269 94039 zinc finger protein 101 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF106 1952.597126 1872.593762 2032.600491 1.085446578 0.118288724 0.714941303 1 8.775818258 9.936009644 64397 zinc finger protein 106 "GO:0003723,GO:0005730,GO:0005829,GO:0008286,GO:0016020,GO:0016607,GO:0017124,GO:0046872" RNA binding|nucleolus|cytosol|insulin receptor signaling pathway|membrane|nuclear speck|SH3 domain binding|metal ion binding ZNF107 205.8148588 194.8715459 216.7581716 1.112313091 0.153562932 0.780606953 1 1.51559526 1.758434585 51427 zinc finger protein 107 "GO:0000978,GO:0001228,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF112 129.9549419 127.884452 132.0254318 1.032380635 0.045974986 0.954309609 1 1.672752155 1.801305511 7771 zinc finger protein 112 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF114 26.07709388 31.46363502 20.69055275 0.657602109 -0.604713169 0.571512629 1 0.541094097 0.371152101 163071 zinc finger protein 114 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0042802,GO:0046872,GO:0070062" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|biological_process|identical protein binding|metal ion binding|extracellular exosome" hsa05168 Herpes simplex virus 1 infection ZNF12 880.5505075 823.1292904 937.9717246 1.139519314 0.188425378 0.602581293 1 8.214501425 9.763798985 7559 zinc finger protein 12 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0006357,GO:0045892,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|centrosome|regulation of transcription by RNA polymerase II|negative regulation of transcription, DNA-templated|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF121 325.4366485 357.2645009 293.6087961 0.821824714 -0.283097379 0.541452687 1 2.496438551 2.140011008 7675 zinc finger protein 121 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF124 104.2193009 119.7648043 88.67379749 0.740399469 -0.433624234 0.521145883 1 1.132076303 0.874294463 7678 zinc finger protein 124 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF131 873.7197206 928.6847111 818.7547302 0.881628308 -0.181757548 0.616098209 1 11.27117288 10.36503008 7690 zinc finger protein 131 "GO:0000122,GO:0000978,GO:0001227,GO:0005654,GO:0006357,GO:0045111,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleoplasm|regulation of transcription by RNA polymerase II|intermediate filament cytoskeleton|metal ion binding" ZNF133 646.9431257 580.5548139 713.3314376 1.228706438 0.297140269 0.440163544 1 6.696208893 8.582089848 7692 zinc finger protein 133 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF134 287.7645115 274.0381115 301.4909115 1.100178767 0.137737964 0.779256205 1 2.818656295 3.234605421 7693 zinc finger protein 134 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF136 72.38179986 64.95718198 79.80641774 1.228600369 0.297015722 0.705012662 1 0.886513638 1.136088052 7695 zinc finger protein 136 "GO:0000122,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF138 94.9362394 91.34603715 98.52644165 1.078606634 0.109168812 0.888827019 1 1.427006333 1.605480065 7697 zinc finger protein 138 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF14 97.41424622 92.36099312 102.4674993 1.109423966 0.149810797 0.83958987 1 1.57872375 1.82692036 7561 zinc finger protein 14 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF140 245.8341123 236.4847406 255.1834839 1.079069555 0.109787862 0.834508867 1 3.016906258 3.39568335 7699 zinc finger protein 140 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0043565,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF141 252.2207636 268.9633316 235.4781956 0.87550297 -0.191816023 0.706102167 1 1.237242861 1.129870084 7700 zinc finger protein 141 "GO:0000122,GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006366,GO:0009653,GO:0035108,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|transcription by RNA polymerase II|anatomical structure morphogenesis|limb morphogenesis|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF142 853.3342482 848.5031896 858.1653068 1.011387249 0.016335495 0.967614038 1 2.843491908 2.999752338 7701 zinc finger protein 142 "GO:0000977,GO:0000981,GO:0003674,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZNF143 481.6819684 463.8348775 499.5290592 1.076954501 0.106957301 0.799386283 1 5.095791808 5.724333948 7702 zinc finger protein 143 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005654,GO:0006355,GO:0006357,GO:0006359,GO:0042795,GO:0045944,GO:0045945,GO:0046872,GO:1905382" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|regulation of transcription by RNA polymerase III|snRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase III|metal ion binding|positive regulation of snRNA transcription by RNA polymerase II" zf-C2H2 ZNF146 1376.787272 1473.716066 1279.858477 0.868456622 -0.203474304 0.544527608 1 20.36521686 18.44816184 7705 zinc finger protein 146 "GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005730,GO:0005829,GO:0006355,GO:0006357,GO:0008201,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleolus|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|heparin binding|zinc ion binding" zf-C2H2 ZNF148 923.472852 962.178258 884.7674461 0.919546289 -0.121005895 0.7369038 1 3.860793409 3.703105531 7707 zinc finger protein 148 "GO:0000122,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005654,GO:0005794,GO:0006357,GO:0006968,GO:0007276,GO:0010629,GO:0021762,GO:0043565,GO:0045892,GO:0045944,GO:0046872,GO:0065003" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|Golgi apparatus|regulation of transcription by RNA polymerase II|cellular defense response|gamete generation|negative regulation of gene expression|substantia nigra development|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|protein-containing complex assembly" ZNF155 147.1822234 126.869496 167.4949508 1.32021452 0.40077237 0.504846226 1 1.207345435 1.66261609 7711 zinc finger protein 155 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF157 11.04574944 14.20938356 7.882115332 0.554711983 -0.850189203 0.555975575 1 0.286031458 0.165499726 7712 zinc finger protein 157 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF16 255.5504228 260.8436839 250.2571618 0.959414305 -0.059774144 0.912260935 1 4.587087634 4.590491174 7564 zinc finger protein 16 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0007049,GO:0008284,GO:0033674,GO:0043066,GO:0045648,GO:0045654,GO:0046872,GO:0051301,GO:0051781,GO:0072707,GO:1901989" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|cell cycle|positive regulation of cell population proliferation|positive regulation of kinase activity|negative regulation of apoptotic process|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|metal ion binding|cell division|positive regulation of cell division|cellular response to sodium dodecyl sulfate|positive regulation of cell cycle phase transition" ZNF160 481.1932955 598.8240213 363.5625697 0.607127565 -0.719928419 0.081509231 1 4.621811057 2.926901236 90338 zinc finger protein 160 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0030097,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|hemopoiesis|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF165 28.4957176 28.41876711 28.57266808 1.005415469 0.007791792 1 1 0.671007132 0.703701747 7718 zinc finger protein 165 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF169 137.3741166 129.914364 144.8338692 1.114841076 0.156838064 0.806722273 1 1.272670063 1.479942082 169841 zinc finger protein 169 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF17 103.9669227 102.5105528 105.4232926 1.028414048 0.040421222 0.967592548 1 1.912968999 2.05206854 7565 zinc finger protein 17 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF174 176.1975432 190.8117221 161.5833643 0.846820953 -0.239871128 0.67511632 1 3.725497525 3.290726618 7727 zinc finger protein 174 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0015629,GO:0042803,GO:0043565,GO:0045892,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|actin cytoskeleton|protein homodimerization activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|sequence-specific double-stranded DNA binding" ZNF175 243.5369764 214.1557093 272.9182434 1.27439163 0.349808696 0.491264079 1 2.852019769 3.791153523 7728 zinc finger protein 175 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0045111,GO:0045944,GO:0046872,GO:0051607" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|intermediate filament cytoskeleton|positive regulation of transcription by RNA polymerase II|metal ion binding|defense response to virus" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF18 91.35148036 115.7049804 66.99798033 0.579041456 -0.788261454 0.260168584 1 0.845727966 0.51080634 7566 zinc finger protein 18 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF180 162.1217716 171.5275587 152.7159846 0.890329145 -0.167589312 0.779695236 1 1.895954983 1.760737205 7733 zinc finger protein 180 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF181 90.54708686 94.39090506 86.70326866 0.918555327 -0.122561474 0.875768293 1 0.676846432 0.64850211 339318 zinc finger protein 181 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF182 355.4157059 318.6961741 392.1352378 1.230435975 0.29916959 0.506945923 1 4.486058067 5.757578142 7569 zinc finger protein 182 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF184 158.3318933 148.1835714 168.4802152 1.136969596 0.185193675 0.758116153 1 2.209945563 2.620875293 7738 zinc finger protein 184 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF185 1363.501294 1104.272094 1622.730494 1.469502402 0.555327717 0.098496731 1 10.81142198 16.57177578 7739 zinc finger protein 185 with LIM domain "GO:0005515,GO:0005737,GO:0005925,GO:0008270,GO:0015629,GO:0051015" protein binding|cytoplasm|focal adhesion|zinc ion binding|actin cytoskeleton|actin filament binding ZNF189 457.3499951 450.64045 464.0595402 1.02977782 0.042333102 0.924681476 1 3.172553381 3.407755297 7743 zinc finger protein 189 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF19 30.94403286 27.40381115 34.48425458 1.258374406 0.331561234 0.758436102 1 0.432909033 0.56822777 7567 zinc finger protein 19 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF195 286.1475596 331.8906017 240.4045176 0.724348675 -0.465243769 0.333087909 1 5.02814482 3.79901823 7748 zinc finger protein 195 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection ZNF197 2.015066161 3.044867905 0.985264417 0.32358199 -1.627796782 0.711605054 1 0.020100602 0.006784367 10168 zinc finger protein 197 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF2 93.95097499 91.34603715 96.55591282 1.057034501 0.080022467 0.923610808 1 1.278351625 1.40946865 7549 zinc finger protein 2 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection ZNF20 103.8481565 94.39090506 113.3054079 1.200384802 0.263496959 0.702769815 1 1.59140025 1.992580335 7568 zinc finger protein 20 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF200 173.0190633 175.5873825 170.4507441 0.970745971 -0.042834281 0.950484174 1 2.35137004 2.380907409 7752 zinc finger protein 200 "GO:0003674,GO:0005515,GO:0005634,GO:0008150,GO:0046872" molecular_function|protein binding|nucleus|biological_process|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF202 305.9743358 306.5167024 305.4319691 0.996461096 -0.005114615 0.999313202 1 3.200822609 3.326885721 7753 zinc finger protein 202 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005694,GO:0005730,GO:0006357,GO:0006629,GO:0016604,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|chromosome|nucleolus|regulation of transcription by RNA polymerase II|lipid metabolic process|nuclear body|metal ion binding" ZNF205 243.8784292 237.4996966 250.2571618 1.053715712 0.075485686 0.889035263 1 5.487464318 6.031302273 7755 zinc finger protein 205 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005739,GO:0006355,GO:0006357,GO:0008270,GO:0010729,GO:1901030" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|mitochondrion|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|positive regulation of hydrogen peroxide biosynthetic process|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway" hsa05168 Herpes simplex virus 1 infection ZNF207 5066.080202 5513.24082 4618.919585 0.837786655 -0.255345191 0.426874475 1 20.32213959 17.7590119 7756 zinc finger protein 207 "GO:0000070,GO:0000776,GO:0000777,GO:0001578,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005819,GO:0005874,GO:0007094,GO:0008017,GO:0008608,GO:0046785,GO:0046872,GO:0050821,GO:0051301,GO:0051983,GO:0090307,GO:1990047" mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|microtubule bundle formation|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|spindle|microtubule|mitotic spindle assembly checkpoint|microtubule binding|attachment of spindle microtubules to kinetochore|microtubule polymerization|metal ion binding|protein stabilization|cell division|regulation of chromosome segregation|mitotic spindle assembly|spindle matrix ZNF208 153.5513074 191.826678 115.2759367 0.600937982 -0.734711986 0.211942039 1 0.860678997 0.539494211 7757 zinc finger protein 208 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0008270,GO:0045944" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|positive regulation of transcription by RNA polymerase II" hsa05168 Herpes simplex virus 1 infection ZNF211 200.3810587 193.85659 206.9055275 1.067312324 0.093982408 0.870057695 1 2.543562797 2.831717456 10520 zinc finger protein 211 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF212 375.7323927 326.8158218 424.6489635 1.299352526 0.3777929 0.393140134 1 5.896711235 7.991950502 7988 zinc finger protein 212 "GO:0000978,GO:0003700,GO:0005515,GO:0005654,GO:0006355,GO:0006357,GO:0008270,GO:0042802" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|identical protein binding" hsa05168 Herpes simplex virus 1 infection ZNF213 221.4724474 221.2604011 221.6844937 1.001916713 0.002762585 1 1 3.331170855 3.481324118 7760 zinc finger protein 213 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF214 49.90158919 43.64310664 56.16007174 1.286802798 0.363790978 0.681897351 1 0.258281069 0.346673385 7761 zinc finger protein 214 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF215 125.9841927 125.8545401 126.1138453 1.002060357 0.002969408 1 1 2.44874701 2.559491723 7762 zinc finger protein 215 "GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF217 2036.02047 2187.230112 1884.810829 0.861734126 -0.214685277 0.505075762 1 12.72842572 11.44099812 7764 zinc finger protein 217 "GO:0000118,GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006355,GO:0016607,GO:0045892,GO:0046872" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription, DNA-templated|nuclear speck|negative regulation of transcription, DNA-templated|metal ion binding" zf-C2H2 ZNF219 404.4980558 340.0102494 468.9858623 1.379328603 0.463966197 0.283541324 1 4.815525629 6.928310941 51222 zinc finger protein 219 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001505,GO:0003677,GO:0003700,GO:0004969,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0007186,GO:0016021,GO:0032332,GO:0045892,GO:0045944,GO:0046872,GO:0060174" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|regulation of neurotransmitter levels|DNA binding|DNA-binding transcription factor activity|histamine receptor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|G protein-coupled receptor signaling pathway|integral component of membrane|positive regulation of chondrocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|limb bud formation" ZNF22 750.7803958 808.9199068 692.6408848 0.856253974 -0.223889316 0.548596381 1 19.48118858 17.3993883 7570 zinc finger protein 22 "GO:0000977,GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0008270,GO:0042476" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|odontogenesis" zf-C2H2 ZNF221 42.10854851 49.73284245 34.48425458 0.693389979 -0.528261108 0.564600098 1 0.833485448 0.602825357 7638 zinc finger protein 221 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF222 59.93238267 55.82257826 64.04218708 1.147245238 0.198173818 0.821980609 1 1.223373716 1.463967175 7673 zinc finger protein 222 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF223 100.3255021 89.31612522 111.3348791 1.246526076 0.317913063 0.646387871 1 0.653314075 0.849452917 7766 zinc finger protein 223 "GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF224 303.3060555 258.8137719 347.798339 1.343816971 0.426336655 0.366551877 1 2.253783444 3.159135366 7767 zinc finger protein 224 "GO:0000122,GO:0000978,GO:0001227,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0017053,GO:0031965,GO:0043565,GO:0045892,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription repressor complex|nuclear membrane|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF225 103.0707329 108.6002886 97.54117724 0.898166833 -0.154944648 0.829624831 1 0.983587536 0.921480098 7768 zinc finger protein 225 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF226 273.7184314 256.78386 290.6530029 1.131897475 0.178743288 0.718381687 1 3.616573034 4.269925137 7769 zinc finger protein 226 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF227 238.7294205 222.2753571 255.1834839 1.148051171 0.199186947 0.700549395 1 3.339502431 3.999069386 7770 zinc finger protein 227 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF23 147.7490845 131.9442759 163.5538931 1.239567932 0.309837337 0.608003665 1 1.859352282 2.404074618 7571 zinc finger protein 23 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF230 99.74379528 83.22638941 116.2612012 1.396927128 0.482256763 0.481174077 1 1.027076759 1.496554658 7773 zinc finger protein 230 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF232 240.3706206 233.4398727 247.3013686 1.059379298 0.083219222 0.877488987 1 3.156984253 3.488508836 7775 zinc finger protein 232 "GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0043231,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|intracellular membrane-bounded organelle|metal ion binding" ZNF233 16.07599196 21.31407534 10.83790858 0.508485985 -0.975720085 0.424699787 1 0.269063491 0.14270845 353355 zinc finger protein 233 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF234 139.3001081 126.869496 151.7307201 1.195959036 0.258167975 0.677487575 1 1.647139812 2.05476755 10780 zinc finger protein 234 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF235 58.21423203 73.07682972 43.35163433 0.593233649 -0.753327664 0.354227838 1 1.160214303 0.717926396 9310 zinc finger protein 235 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF236 938.9995503 945.9389625 932.0601381 0.985327992 -0.021324053 0.955476719 1 5.184338424 5.328317484 7776 zinc finger protein 236 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:0071333" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|cellular response to glucose stimulus" zf-C2H2 ZNF239 111.2943011 131.9442759 90.64432632 0.686989456 -0.541640138 0.410055115 1 1.376702122 0.986520202 8187 zinc finger protein 239 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|RNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF24 2206.980176 1986.26883 2427.691522 1.222237134 0.289524219 0.366304501 1 16.0801645 20.50037906 7572 zinc finger protein 24 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0042552,GO:0042802,GO:0043565,GO:0045892,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|myelination|identical protein binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF248 391.9689666 392.7879598 391.1499734 0.995829846 -0.00602884 0.995661652 1 1.74075293 1.808165601 57209 zinc finger protein 248 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF25 103.637594 113.6750685 93.60011957 0.8234006 -0.280333595 0.683940979 1 1.155144702 0.992118389 219749 zinc finger protein 25 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF250 309.351254 267.9483757 350.7541323 1.309036233 0.38850503 0.40800203 1 1.581659669 2.159636396 58500 zinc finger protein 250 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF251 453.5601168 427.2964627 479.8237709 1.122929424 0.167267258 0.692864137 1 4.247509013 4.975110152 90987 zinc finger protein 251 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF253 117.5055247 118.7498483 116.2612012 0.979042945 -0.030555951 0.976783969 1 1.673417054 1.708920511 56242 zinc finger protein 253 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0045892,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|negative regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF254 260.402516 255.768904 265.0361281 1.036232802 0.051348158 0.925278129 1 2.283411368 2.468069723 9534 zinc finger protein 254 "GO:0000122,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF256 48.34946369 38.5683268 58.13060058 1.507210849 0.591881255 0.496904664 1 0.885070091 1.391450004 10172 zinc finger protein 256 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0045892,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|negative regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF257 39.46723816 37.55337083 41.38110549 1.101927858 0.140029776 0.905216405 1 0.467883334 0.537782503 113835 zinc finger protein 257 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF26 284.5239269 288.247495 280.8003587 0.97416409 -0.037763292 0.94512932 1 0.751581484 0.763702335 7574 zinc finger protein 26 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF260 325.6053952 301.4419226 349.7688679 1.160319258 0.214521812 0.645110114 1 2.430272199 2.94136113 339324 zinc finger protein 260 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007275,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding" zf-C2H2 ZNF263 505.444359 505.4480723 505.4406457 0.999985307 -2.12E-05 1 1 5.847227443 6.099012673 10127 zinc finger protein 263 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0043565,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF264 237.0882203 211.1108414 263.0655992 1.246101799 0.317421932 0.53653055 1 1.750494329 2.275255437 9422 zinc finger protein 264 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF266 550.487174 452.6703619 648.3039861 1.432176791 0.518209593 0.194287562 1 5.764686172 8.611686879 10781 zinc finger protein 266 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF267 211.9788235 212.1257974 211.8318496 0.998614276 -0.002000564 1 1 3.142270636 3.273085024 10308 zinc finger protein 267 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0007275,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF268 602.4077887 634.3474802 570.4680972 0.899299067 -0.153127123 0.697547394 1 2.389724935 2.241650944 10795 zinc finger protein 268 "GO:0000122,GO:0000978,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0007346,GO:0008284,GO:0008285,GO:0015629,GO:0030154,GO:0030335,GO:0043065,GO:0043066,GO:0045597,GO:0045944,GO:0046872,GO:0071157" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|regulation of mitotic cell cycle|positive regulation of cell population proliferation|negative regulation of cell population proliferation|actin cytoskeleton|cell differentiation|positive regulation of cell migration|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of cell cycle arrest" hsa05168 Herpes simplex virus 1 infection ZNF273 106.2964717 93.37594909 119.2169944 1.276741983 0.352467 0.602027015 1 0.431571675 0.574740766 10793 zinc finger protein 273 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF274 191.3058381 179.6472064 202.9644698 1.129794745 0.176060696 0.754313182 1 2.522455572 2.972617334 10782 zinc finger protein 274 "GO:0000122,GO:0000978,GO:0000981,GO:0003682,GO:0005515,GO:0005730,GO:0005737,GO:0006355,GO:0006357,GO:0043565,GO:0046872,GO:1900112,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|chromatin binding|protein binding|nucleolus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding|regulation of histone H3-K9 trimethylation|sequence-specific double-stranded DNA binding" hsa04722 Neurotrophin signaling pathway ZNF275 560.5625048 467.8947014 653.2303082 1.396105376 0.481407838 0.225836623 1 3.748373299 5.458545878 10838 zinc finger protein 275 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF276 272.1042012 281.1428032 263.0655992 0.93570099 -0.095880516 0.850850725 1 2.251564069 2.197542728 92822 zinc finger protein 276 "GO:0000776,GO:0000777,GO:0005515,GO:0005634,GO:0005694,GO:0006357,GO:0008270,GO:0043035,GO:1990837" kinetochore|condensed chromosome kinetochore|protein binding|nucleus|chromosome|regulation of transcription by RNA polymerase II|zinc ion binding|chromatin insulator sequence binding|sequence-specific double-stranded DNA binding ZNF277 493.460604 460.7900096 526.1311984 1.141802529 0.191313163 0.643251224 1 11.6454034 13.86952117 11179 zinc finger protein 277 "GO:0000978,GO:0005634,GO:0046872,GO:0070301,GO:2000772" RNA polymerase II cis-regulatory region sequence-specific DNA binding|nucleus|metal ion binding|cellular response to hydrogen peroxide|regulation of cellular senescence ZNF28 251.5027231 287.232539 215.7729072 0.751213313 -0.412705464 0.410768979 1 1.763310886 1.381681982 7576 zinc finger protein 28 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF280C 252.8348836 243.5894324 262.0803348 1.075910117 0.105557559 0.839501801 1 2.659970983 2.985168294 55609 zinc finger protein 280C "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF280D 315.1265069 292.3073189 337.9456949 1.156131486 0.209305483 0.656747359 1 1.462156494 1.763262682 54816 zinc finger protein 280D "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF281 1269.103462 1184.453615 1353.753308 1.142934844 0.192743162 0.57063177 1 12.33314085 14.70317392 23528 zinc finger protein 281 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0010172,GO:0010629,GO:0043565,GO:0045892,GO:0045893,GO:0046872,GO:0048863,GO:1990837" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|embryonic body morphogenesis|negative regulation of gene expression|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|stem cell differentiation|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF282 886.9074672 853.5779694 920.2369651 1.078093622 0.108482468 0.765434398 1 11.65248326 13.10360806 8427 zinc finger protein 282 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006355,GO:0006357,GO:0008270,GO:0045892,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|negative regulation of transcription, DNA-templated|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF283 194.7070046 210.0958855 179.3181238 0.853506119 -0.228526599 0.679695984 1 0.633520804 0.564005644 284349 zinc finger protein 283 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF284 90.80218665 78.15160956 103.4527637 1.323744505 0.404624696 0.569403259 1 1.576305584 2.176509235 342909 zinc finger protein 284 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF285 21.06169715 25.37389921 16.74949508 0.66010726 -0.59922763 0.604238768 1 0.204731318 0.140966112 26974 zinc finger protein 285 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF286A 365.2480611 384.668312 345.8278102 0.89902859 -0.153561099 0.734293577 1 3.587862426 3.364536273 57335 zinc finger protein 286A "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF292 1098.822702 1297.113728 900.5316767 0.694258073 -0.526456047 0.129348173 1 3.219832101 2.331686155 23036 zinc finger protein 292 "GO:0000981,GO:0001228,GO:0003677,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF296 40.52673146 42.62815067 38.42531225 0.901406973 -0.149749485 0.894676394 1 1.321276284 1.242311435 162979 zinc finger protein 296 "GO:0000122,GO:0000978,GO:0003700,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0007283,GO:0008134,GO:0045944,GO:0046872,GO:1990837" negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|spermatogenesis|transcription factor binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding ZNF3 551.96903 587.6595057 516.2785543 0.878533486 -0.186830818 0.641654352 1 7.113499241 6.518648132 7551 zinc finger protein 3 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007275,GO:0008270,GO:0030154,GO:0042802,GO:0045321" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|zinc ion binding|cell differentiation|identical protein binding|leukocyte activation" hsa05168 Herpes simplex virus 1 infection ZNF30 74.02300002 76.12169763 71.92430241 0.944859411 -0.081828413 0.931534061 1 0.98727156 0.97301548 90075 zinc finger protein 30 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF302 309.1406915 287.232539 331.048844 1.152546453 0.204824899 0.665760506 1 4.023040599 4.836473176 55900 zinc finger protein 302 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF304 270.3887722 264.9035077 275.8740366 1.041413302 0.058542739 0.912228399 1 2.877209553 3.125435522 57343 zinc finger protein 304 "GO:0000978,GO:0000981,GO:0001525,GO:0005515,GO:0005634,GO:0006325,GO:0006357,GO:0007229,GO:0007265,GO:0030335,GO:0035562,GO:0045766,GO:0045944,GO:0046872,GO:0050679,GO:0090309,GO:1900114,GO:1902466,GO:1990841,GO:2000811" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|angiogenesis|protein binding|nucleus|chromatin organization|regulation of transcription by RNA polymerase II|integrin-mediated signaling pathway|Ras protein signal transduction|positive regulation of cell migration|negative regulation of chromatin binding|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of epithelial cell proliferation|positive regulation of DNA methylation-dependent heterochromatin assembly|positive regulation of histone H3-K9 trimethylation|positive regulation of histone H3-K27 trimethylation|promoter-specific chromatin binding|negative regulation of anoikis" hsa05168 Herpes simplex virus 1 infection ZNF311 71.33715234 60.8973581 81.77694657 1.342865259 0.425314554 0.582179091 1 0.794292134 1.112573291 282890 zinc finger protein 311 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF316 840.2558652 863.7275291 816.7842013 0.945650305 -0.080621311 0.827337528 1 7.756161755 7.650562272 100131017 zinc finger protein 316 "GO:0000981,GO:0005634,GO:0006357,GO:0043565,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF317 640.2486725 661.7512914 618.7460536 0.93501299 -0.096941687 0.804501682 1 7.817907252 7.624723305 57693 zinc finger protein 317 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF318 898.8088285 993.641893 803.9757639 0.809120237 -0.305573989 0.395299204 1 6.129653657 5.173267428 24149 zinc finger protein 318 "GO:0003676,GO:0005654,GO:0005829,GO:0008270,GO:0042803,GO:0045892,GO:0045893,GO:0051321" "nucleic acid binding|nucleoplasm|cytosol|zinc ion binding|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|meiotic cell cycle" ZNF319 397.4176124 394.8178717 400.0173531 1.013169316 0.018875291 0.971739021 1 3.977746642 4.203732537 57567 zinc finger protein 319 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF32 355.0094268 358.2794568 351.7393967 0.981745925 -0.02657839 0.959585344 1 12.26053416 12.55522293 7580 zinc finger protein 32 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF320 689.7170126 709.4542219 669.9798033 0.944359456 -0.08259199 0.830657248 1 3.342451492 3.292443844 162967 zinc finger protein 320 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF322 243.5693895 182.6920743 304.4467047 1.666447249 0.73677565 0.145614381 1 1.893718597 3.291720443 79692 zinc finger protein 322 "GO:0000978,GO:0000981,GO:0005654,GO:0005813,GO:0005829,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleoplasm|centrosome|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" other ZNF324 210.4591111 175.5873825 245.3308397 1.397200848 0.482539423 0.363933119 1 2.23383107 3.255555454 25799 zinc finger protein 324 "GO:0000082,GO:0000978,GO:0000981,GO:0003674,GO:0005575,GO:0005634,GO:0006357,GO:0008283,GO:0046872" "G1/S transition of mitotic cell cycle|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|cellular_component|nucleus|regulation of transcription by RNA polymerase II|cell population proliferation|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF324B 64.8262916 87.28621328 42.36636991 0.485372985 -1.042834281 0.183481704 1 1.422374123 0.72012083 388569 zinc finger protein 324B "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF326 654.0733036 832.2638941 475.8827132 0.571793053 -0.806435002 0.035992365 0.858303341 5.408163996 3.225556527 284695 zinc finger protein 326 "GO:0000993,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0016363,GO:0032784,GO:0043231,GO:0043484,GO:0044609,GO:0046872" "RNA polymerase II complex binding|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|nuclear matrix|regulation of DNA-templated transcription, elongation|intracellular membrane-bounded organelle|regulation of RNA splicing|DBIRD complex|metal ion binding" ZNF329 187.7534922 172.5425146 202.9644698 1.176315705 0.23427531 0.675815803 1 1.961101812 2.406245674 79673 zinc finger protein 329 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF330 453.9609527 454.7002738 453.2216316 0.996748095 -0.004699152 0.997076456 1 10.18980743 10.59417934 27309 zinc finger protein 330 "GO:0000775,GO:0005515,GO:0005634,GO:0005730,GO:0008150,GO:0008270,GO:0030496,GO:0046872" "chromosome, centromeric region|protein binding|nucleus|nucleolus|biological_process|zinc ion binding|midbody|metal ion binding" ZNF331 300.5999188 309.5615704 291.6382673 0.942101007 -0.086046348 0.861906069 1 1.731823867 1.701833697 55422 zinc finger protein 331 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF333 50.94623671 47.70293051 54.18954291 1.135979327 0.183936581 0.847801031 1 0.203382873 0.240990951 84449 zinc finger protein 333 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF335 984.7359113 1176.333967 793.1378553 0.674245476 -0.568654159 0.107856482 1 12.02607299 8.457807688 63925 zinc finger protein 335 "GO:0000976,GO:0000978,GO:0001701,GO:0002052,GO:0005515,GO:0005634,GO:0005654,GO:0007420,GO:0010468,GO:0021895,GO:0035097,GO:0040029,GO:0045944,GO:0046872,GO:0048812,GO:0048854,GO:0050671,GO:0050769,GO:0051569,GO:0080182" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|in utero embryonic development|positive regulation of neuroblast proliferation|protein binding|nucleus|nucleoplasm|brain development|regulation of gene expression|cerebral cortex neuron differentiation|histone methyltransferase complex|regulation of gene expression, epigenetic|positive regulation of transcription by RNA polymerase II|metal ion binding|neuron projection morphogenesis|brain morphogenesis|positive regulation of lymphocyte proliferation|positive regulation of neurogenesis|regulation of histone H3-K4 methylation|histone H3-K4 trimethylation" zf-C2H2 ZNF337 1359.053996 1271.739828 1446.368163 1.137314513 0.185631272 0.581236225 1 6.794212645 8.060011215 26152 zinc finger protein 337 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF33A 993.557516 1004.806409 982.3086233 0.977609831 -0.032669302 0.929124147 1 7.729328654 7.881761044 7581 zinc finger protein 33A "GO:0000978,GO:0001228,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF33B 711.1552973 693.2149264 729.0956682 1.051759909 0.072805411 0.84990745 1 5.713407731 6.267982285 7582 zinc finger protein 33B "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF34 151.8534457 143.1087915 160.5980999 1.122209881 0.166342521 0.786613659 1 1.629486384 1.9073955 80778 zinc finger protein 34 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF341 144.9714406 144.1237475 145.8191336 1.011763406 0.016871965 0.99061487 1 2.183475732 2.304322533 84905 zinc finger protein 341 "GO:0000978,GO:0000981,GO:0001216,GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0045893,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity|DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of transcription, DNA-templated|metal ion binding" zf-C2H2 ZNF343 680.9414291 682.0504107 679.8324474 0.996748095 -0.004699152 0.99454477 1 8.565198903 8.905099915 79175 zinc finger protein 343 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF345 82.74192201 65.97213794 99.51170607 1.508389893 0.593009388 0.414443883 1 0.848034531 1.334268029 25850 zinc finger protein 345 "GO:0000122,GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006359,GO:0006366,GO:0006383,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of transcription by RNA polymerase III|transcription by RNA polymerase II|transcription by RNA polymerase III|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF346 381.7303322 366.3991046 397.0615599 1.083685945 0.11594672 0.796628192 1 2.483182399 2.806906794 23567 zinc finger protein 346 "GO:0003723,GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0008270,GO:0019899,GO:0035198" RNA binding|double-stranded RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|zinc ion binding|enzyme binding|miRNA binding ZNF347 387.0332419 324.7859099 449.2805739 1.383313008 0.468127638 0.285325209 1 1.97802556 2.854094114 84671 zinc finger protein 347 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF35 185.2133807 200.9612817 169.4654796 0.843274277 -0.245926147 0.661639358 1 3.829187348 3.368149796 7584 zinc finger protein 35 "GO:0000977,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007283,GO:0043565,GO:0046872,GO:0048471,GO:0071300" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spermatogenesis|sequence-specific DNA binding|metal ion binding|perinuclear region of cytoplasm|cellular response to retinoic acid" zf-C2H2 ZNF350 101.8479361 92.36099312 111.3348791 1.20543181 0.269550041 0.698005723 1 1.129620495 1.42033615 59348 zinc finger protein 350 "GO:0000122,GO:0000978,GO:0001162,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0016363,GO:0016604,GO:0017053,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nuclear matrix|nuclear body|transcription repressor complex|negative regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection other ZNF354A 263.4325382 260.8436839 266.0213925 1.019849852 0.028356767 0.962502696 1 4.127089156 4.390318401 6940 zinc finger protein 354A "GO:0000122,GO:0000978,GO:0000981,GO:0001666,GO:0001822,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0007576,GO:0007605,GO:0046872,GO:0051593" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|response to hypoxia|kidney development|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|nucleolar fragmentation|sensory perception of sound|metal ion binding|response to folic acid" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF354B 154.6904728 134.9891438 174.3918017 1.291895013 0.369488833 0.532393684 1 2.446930537 3.297348059 117608 zinc finger protein 354B "GO:0000122,GO:0000978,GO:0000981,GO:0003682,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|chromatin binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF358 920.1513576 869.8172649 970.4854503 1.115734867 0.157994239 0.660212605 1 20.85851133 24.27505623 140467 zinc finger protein 358 "GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0019827,GO:0021915,GO:0035115,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|stem cell population maintenance|neural tube development|embryonic forelimb morphogenesis|metal ion binding ZNF362 297.4511305 296.3671428 298.5351182 1.007315168 0.010515143 0.990359531 1 3.50454127 3.682243312 149076 zinc finger protein 362 "GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF365 6.985925571 6.08973581 7.882115332 1.294327961 0.372203218 0.905012836 1 0.068401782 0.092348039 22891 zinc finger protein 365 "GO:0000723,GO:0005515,GO:0005737,GO:0005813,GO:0010569,GO:0010977,GO:0021687,GO:0034451,GO:0043231,GO:0046872,GO:0048714,GO:0060997,GO:0110026,GO:0140059" telomere maintenance|protein binding|cytoplasm|centrosome|regulation of double-strand break repair via homologous recombination|negative regulation of neuron projection development|cerebellar molecular layer morphogenesis|centriolar satellite|intracellular membrane-bounded organelle|metal ion binding|positive regulation of oligodendrocyte differentiation|dendritic spine morphogenesis|regulation of DNA strand resection involved in replication fork processing|dendrite arborization ZNF367 444.2824985 331.8906017 556.6743953 1.677282793 0.746125951 0.07715591 1 3.465076919 6.062267573 195828 zinc finger protein 367 "GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" ZNF37A 566.8546383 561.2706505 572.438626 1.019897665 0.028424402 0.947529893 1 2.277389714 2.422757139 7587 zinc finger protein 37A "GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF382 1.970528833 0 3.941057666 Inf Inf 0.26888406 1 0 0.024975846 84911 zinc finger protein 382 "GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF383 76.72369347 92.36099312 61.08639383 0.661387365 -0.596432611 0.423414584 1 0.760363861 0.524557729 163087 zinc finger protein 383 "GO:0000978,GO:0003700,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0031965,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|nuclear membrane|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF384 1311.063552 1224.036898 1398.090207 1.142196129 0.191810401 0.570651481 1 14.05103144 16.74036102 171017 zinc finger protein 384 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF385A 17.46481393 15.22433953 19.70528833 1.294327961 0.372203218 0.786584994 1 0.244315301 0.329845778 25946 zinc finger protein 385A "GO:0000785,GO:0002039,GO:0003677,GO:0003723,GO:0003730,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006915,GO:0006974,GO:0006977,GO:0007599,GO:0007611,GO:0007626,GO:0008270,GO:0010609,GO:0030220,GO:0030425,GO:0035855,GO:0043025,GO:0045600,GO:0070889,GO:1901796,GO:1902164,GO:1902166,GO:2000765" "chromatin|p53 binding|DNA binding|RNA binding|mRNA 3'-UTR binding|nucleus|nucleoplasm|nucleolus|cytoplasm|apoptotic process|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|hemostasis|learning or memory|locomotory behavior|zinc ion binding|mRNA localization resulting in posttranscriptional regulation of gene expression|platelet formation|dendrite|megakaryocyte development|neuronal cell body|positive regulation of fat cell differentiation|platelet alpha granule organization|regulation of signal transduction by p53 class mediator|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of cytoplasmic translation" ZNF385B 162.3202099 117.7348923 206.9055275 1.757384947 0.813430241 0.15955371 1 0.679218243 1.245065426 151126 zinc finger protein 385B "GO:0002039,GO:0003676,GO:0005634,GO:0008270,GO:0072332" p53 binding|nucleic acid binding|nucleus|zinc ion binding|intrinsic apoptotic signaling pathway by p53 class mediator ZNF391 131.6879383 111.6451565 151.7307201 1.359044359 0.442592546 0.477545926 1 1.189155272 1.685730433 346157 zinc finger protein 391 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF394 347.0206694 384.668312 309.3730268 0.804259195 -0.314267571 0.488637161 1 7.470127675 6.266715646 84124 zinc finger protein 394 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF395 1619.533216 1869.548894 1369.517539 0.732539033 -0.44902246 0.171940738 1 19.73859831 15.08214145 55893 zinc finger protein 395 "GO:0000978,GO:0000987,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0016607,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nuclear speck|positive regulation of transcription by RNA polymerase II|metal ion binding" other ZNF396 43.07896716 48.71788648 37.44004783 0.768507227 -0.379869269 0.683786898 1 0.535109322 0.428949733 252884 zinc finger protein 396 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0005737,GO:0006357,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF397 173.4941281 208.0659735 138.9222827 0.667683814 -0.582763028 0.302828311 1 0.965000691 0.672069834 84307 zinc finger protein 397 "GO:0000978,GO:0000981,GO:0005515,GO:0005730,GO:0005829,GO:0005886,GO:0006357,GO:0015630,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleolus|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|microtubule cytoskeleton|metal ion binding" ZNF398 414.223769 432.3712425 396.0762955 0.916056057 -0.12649221 0.772482852 1 3.488621654 3.333433935 57541 zinc finger protein 398 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0045893,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF404 27.46591585 25.37389921 29.5579325 1.164895165 0.220200125 0.860398291 1 0.695023516 0.84450509 342908 zinc finger protein 404 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF407 588.0890415 665.8111153 510.3669678 0.766534166 -0.383577998 0.329123198 1 1.642602375 1.313348229 55628 zinc finger protein 407 "GO:0003677,GO:0005634,GO:0008270,GO:0010468,GO:0045944" DNA binding|nucleus|zinc ion binding|regulation of gene expression|positive regulation of transcription by RNA polymerase II ZNF408 259.5926793 301.4419226 217.7434361 0.722339594 -0.469250843 0.344153105 1 6.849246279 5.160599228 79797 zinc finger protein 408 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding" ZNF41 490.8165721 482.104085 499.5290592 1.036143594 0.051223953 0.905592357 1 4.01329243 4.337471976 7592 zinc finger protein 41 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF410 1054.059481 1032.21022 1075.908743 1.042334906 0.059818896 0.86644192 1 17.94022176 19.50522744 57862 zinc finger protein 410 "GO:0003712,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" transcription coregulator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding zf-C2H2 ZNF414 108.8041701 96.420817 121.1875232 1.256860572 0.329824616 0.623535574 1 1.9867267 2.604600747 84330 zinc finger protein 414 "GO:0000785,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF415 68.5595084 73.07682972 64.04218708 0.87636789 -0.19039147 0.819720219 1 1.232872627 1.126991386 55786 zinc finger protein 415 "GO:0000978,GO:0000981,GO:0001650,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0015630,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|microtubule cytoskeleton|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF416 99.95163614 97.43577296 102.4674993 1.051641468 0.072642936 0.92987237 1 1.552793634 1.703324426 55659 zinc finger protein 416 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF417 209.9043742 205.0211056 214.7876428 1.04763674 0.067138561 0.908226177 1 1.767119763 1.931046067 147687 zinc finger protein 417 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF419 93.14658149 70.03196182 116.2612012 1.660116297 0.731284311 0.293513512 1 0.93560322 1.620116148 79744 zinc finger protein 419 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF420 108.2670006 93.37594909 123.1580521 1.31894833 0.399388047 0.550356228 1 0.868852179 1.195334919 147923 zinc finger protein 420 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0042981,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|regulation of apoptotic process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF425 71.18597298 84.24134538 58.13060058 0.69004834 -0.535230663 0.48503438 1 1.334123501 0.960265841 155054 zinc finger protein 425 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|negative regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF426 326.4422019 291.2923629 361.5920409 1.241337182 0.311895045 0.500226719 1 1.955843904 2.532444197 79088 zinc finger protein 426 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF428 297.480822 298.3970547 296.5645894 0.99385897 -0.008886949 0.993124208 1 13.00581595 13.48274421 126299 zinc finger protein 428 "GO:0005515,GO:0046872" protein binding|metal ion binding ZNF429 65.68066563 44.65806261 86.70326866 1.941491941 0.957165719 0.220344218 1 0.274887376 0.556680895 353088 zinc finger protein 429 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF43 90.93579863 87.28621328 94.58538399 1.083623409 0.115863465 0.883321529 1 0.36894832 0.417022844 7594 zinc finger protein 43 "GO:0000978,GO:0001228,GO:0003677,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF430 155.4206374 151.2284393 159.6128355 1.055441928 0.077847201 0.905071724 1 1.970969364 2.169852167 80264 zinc finger protein 430 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0021762,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|substantia nigra development|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF431 303.8998865 299.4120107 308.3877624 1.029977928 0.042613421 0.935174325 1 1.077229671 1.157316526 170959 zinc finger protein 431 "GO:0000122,GO:0000978,GO:0000981,GO:0003682,GO:0005634,GO:0006355,GO:0030154,GO:0043433,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|chromatin binding|nucleus|regulation of transcription, DNA-templated|cell differentiation|negative regulation of DNA-binding transcription factor activity|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF432 150.0165289 152.2433953 147.7896625 0.970745971 -0.042834281 0.954426147 1 1.577130474 1.596942024 9668 zinc finger protein 432 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF433 45.99022308 45.67301858 46.30742758 1.013890236 0.019901474 1 1 0.725133939 0.766875923 163059 zinc finger protein 433 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF436 329.3210447 319.71113 338.9309593 1.060116234 0.084222455 0.860516263 1 3.41969184 3.781432802 80818 zinc finger protein 436 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF438 200.0665758 206.0360616 194.0970901 0.942053971 -0.086118379 0.881793531 1 0.963082572 0.946357522 220929 zinc finger protein 438 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF439 39.90048727 33.49354696 46.30742758 1.382577594 0.467360451 0.620037138 1 0.588390564 0.848537702 90594 zinc finger protein 439 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF44 128.9548317 126.869496 131.0401674 1.032873713 0.04666387 0.953634649 1 0.940499474 1.013261896 51710 zinc finger protein 44 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF440 308.4550642 274.0381115 342.872017 1.251183695 0.323293618 0.492329496 1 3.000878616 3.916385507 126070 zinc finger protein 440 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF441 91.84683417 82.21143344 101.4822349 1.23440537 0.303816243 0.671839482 1 0.936087922 1.205286727 126068 zinc finger protein 441 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF442 19.47988009 18.26920743 20.69055275 1.132536966 0.17955814 0.919067072 1 0.135789684 0.16041135 79973 zinc finger protein 442 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF443 60.99187596 60.8973581 61.08639383 1.00310417 0.004471434 1 1 1.198692715 1.254208764 10224 zinc finger protein 443 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0006915,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|apoptotic process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF444 371.0584488 344.0700733 398.0468243 1.156877204 0.210235738 0.638287016 1 4.022607434 4.854123762 55311 zinc finger protein 444 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF445 951.4274407 852.5630134 1050.291868 1.231922863 0.300911924 0.397669195 1 2.357721359 3.029646255 353274 zinc finger protein 445 "GO:0000978,GO:0001228,GO:0003682,GO:0005634,GO:0006357,GO:0010216,GO:0010385,GO:0045944,GO:0046872,GO:0071517,GO:2000653" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|nucleus|regulation of transcription by RNA polymerase II|maintenance of DNA methylation|double-stranded methylated DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|maintenance of imprinting at mating-type locus|regulation of genetic imprinting" ZNF446 368.8949249 330.8756457 406.914204 1.229810079 0.298435536 0.503194411 1 7.305006188 9.370754626 55663 zinc finger protein 446 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005615,GO:0005634,GO:0006357,GO:0046872" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|extracellular space|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF449 237.263648 256.78386 217.7434361 0.847963871 -0.237925297 0.64500604 1 2.799827046 2.476421029 203523 zinc finger protein 449 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0007284,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|spermatogonial cell division|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF45 357.6534587 336.9653815 378.341536 1.12279052 0.167088788 0.71316125 1 4.075975121 4.77360183 7596 zinc finger protein 45 "GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0007275,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|multicellular organism development|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF451 841.4328869 708.4392659 974.426508 1.37545525 0.459909203 0.20626609 1 2.490279678 3.572814923 26036 zinc finger protein 451 "GO:0003714,GO:0005515,GO:0005634,GO:0010468,GO:0016605,GO:0016925,GO:0030512,GO:0045944,GO:0046872,GO:0060633,GO:0061665,GO:2000616" transcription corepressor activity|protein binding|nucleus|regulation of gene expression|PML body|protein sumoylation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of transcription initiation from RNA polymerase II promoter|SUMO ligase activity|negative regulation of histone H3-K9 acetylation ZNF460 35.84066339 25.37389921 46.30742758 1.825002425 0.867898381 0.35912636 1 0.321837837 0.612655696 10794 zinc finger protein 460 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF461 68.9333744 64.95718198 72.90956682 1.122425028 0.166619084 0.844353558 1 0.661143913 0.774050465 92283 zinc finger protein 461 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF462 1106.675126 1295.083816 918.2664362 0.70904016 -0.49606075 0.152423347 1 4.485497263 3.317396333 58499 zinc finger protein 462 "GO:0003677,GO:0005515,GO:0005634,GO:0006325,GO:0010468,GO:0043392,GO:0045944,GO:0046872" DNA binding|protein binding|nucleus|chromatin organization|regulation of gene expression|negative regulation of DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding ZNF467 9.582698596 15.22433953 3.941057666 0.258865592 -1.949724877 0.186253211 1 0.274495938 0.074118425 168544 zinc finger protein 467 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF468 316.2156917 299.4120107 333.0193728 1.112244536 0.153474011 0.746186431 1 3.18040312 3.689762234 90333 zinc finger protein 468 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF473 325.4839074 326.8158218 324.151993 0.991849144 -0.011807386 0.987092525 1 3.565719181 3.689000293 25888 zinc finger protein 473 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006369,GO:0006398,GO:0008334,GO:0015030,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|termination of RNA polymerase II transcription|mRNA 3'-end processing by stem-loop binding and cleavage|histone mRNA metabolic process|Cajal body|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF474 1.522433953 3.044867905 0 0 #NAME? 0.372134169 1 0.079943918 0 133923 zinc finger protein 474 "GO:0005515,GO:0046872" protein binding|metal ion binding ZNF48 293.3616151 286.2175831 300.505647 1.049920287 0.070279799 0.889544046 1 4.629802257 5.070312178 197407 zinc finger protein 48 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF480 223.8613796 216.1856213 231.5371379 1.071010813 0.098973045 0.85667525 1 2.10235005 2.348631139 147657 zinc finger protein 480 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF483 301.8484478 192.841634 410.8552617 2.130531946 1.091213684 0.021701988 0.640846954 0.58508048 1.300228225 158399 zinc finger protein 483 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF484 143.3896235 137.0190557 149.7601913 1.092988056 0.128277635 0.841180377 1 1.389852153 1.584528116 83744 zinc finger protein 484 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF485 88.35114978 112.6601125 64.04218708 0.568454848 -0.814882335 0.249630989 1 0.976692444 0.579121558 220992 zinc finger protein 485 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF486 271.8100073 227.3501369 316.2698777 1.391113645 0.476240284 0.329847838 1 2.95622141 4.289587176 90649 zinc finger protein 486 "GO:0000978,GO:0000981,GO:0003674,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0046872,GO:0070062" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|biological_process|metal ion binding|extracellular exosome" hsa05168 Herpes simplex virus 1 infection ZNF487 53.29063155 39.58328277 66.99798033 1.692582718 0.759226341 0.364616778 1 0.626094201 1.105364501 642819 zinc finger protein 487 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF488 69.33693195 58.86744617 79.80641774 1.355696959 0.439034727 0.573386617 1 0.735247466 1.039709682 118738 zinc finger protein 488 "GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0014003,GO:0046872" "DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|oligodendrocyte development|metal ion binding" ZNF490 95.41402584 90.33108119 100.4969705 1.112540326 0.15385763 0.836270348 1 0.749009593 0.869198706 57474 zinc finger protein 490 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF491 21.50979203 22.3290313 20.69055275 0.926621154 -0.109948477 0.966121451 1 0.282227767 0.272783364 126069 zinc finger protein 491 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF492 68.94822018 65.97213794 71.92430241 1.090222398 0.124622465 0.888835769 1 0.786918524 0.89487175 57615 zinc finger protein 492 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF493 100.1918902 80.1815215 120.2022588 1.499126689 0.584122308 0.391002021 1 0.638708902 0.998751018 284443 zinc finger protein 493 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF496 1522.421575 1360.040998 1684.802152 1.238787768 0.308929043 0.350717424 1 10.37212447 13.40233774 84838 zinc finger protein 496 "GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0045893,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription, DNA-templated|metal ion binding" ZNF497 29.01804136 30.44867905 27.58740366 0.906029572 -0.142369955 0.921358126 1 0.445055751 0.420603343 162968 zinc finger protein 497 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF500 225.5768086 232.4249168 218.7287005 0.941072513 -0.087622203 0.873700518 1 1.689608452 1.658536722 26048 zinc finger protein 500 "GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" ZNF501 49.91643497 44.65806261 55.17480733 1.235494872 0.305089022 0.735137401 1 0.73914161 0.952542865 115560 zinc finger protein 501 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0005730,GO:0006357,GO:0007030,GO:0046872,GO:1990837" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleolus|regulation of transcription by RNA polymerase II|Golgi organization|metal ion binding|sequence-specific double-stranded DNA binding ZNF503 167.600109 175.5873825 159.6128355 0.909022238 -0.137612506 0.818221766 1 2.774690012 2.630903439 84858 zinc finger protein 503 "GO:0005515,GO:0005634,GO:0008285,GO:0010629,GO:0045892,GO:0046872,GO:0061351,GO:0070315,GO:0070491" "protein binding|nucleus|negative regulation of cell population proliferation|negative regulation of gene expression|negative regulation of transcription, DNA-templated|metal ion binding|neural precursor cell proliferation|G1 to G0 transition involved in cell differentiation|repressing transcription factor binding" ZNF506 89.47274779 88.30116925 90.64432632 1.026535969 0.037784179 0.974774346 1 1.34581484 1.441037936 440515 zinc finger protein 506 "GO:0000978,GO:0000981,GO:0005730,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleolus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF507 501.5505602 474.9993932 528.1017273 1.11179453 0.15289019 0.711118848 1 3.1178128 3.61568426 22847 zinc finger protein 507 "GO:0003677,GO:0005634,GO:0010468,GO:0045944,GO:0046872" DNA binding|nucleus|regulation of gene expression|positive regulation of transcription by RNA polymerase II|metal ion binding ZNF510 420.9573164 421.2067269 420.7079059 0.998815734 -0.001709548 1 1 3.231727736 3.366945372 22869 zinc finger protein 510 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF511 351.4598025 317.6812181 385.2383869 1.212657107 0.278171669 0.538977655 1 14.84265035 18.77437132 118472 zinc finger protein 511 "GO:0000785,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF512 457.1124627 434.4011545 479.8237709 1.104563756 0.143476694 0.735005766 1 6.080952459 7.006132179 84450 zinc finger protein 512 "GO:0003677,GO:0005515,GO:0005634,GO:0046872" DNA binding|protein binding|nucleus|metal ion binding ZNF512B 1673.145012 1998.448302 1347.841722 0.674444128 -0.568229162 0.083058775 1 13.65547172 9.606575816 57473 zinc finger protein 512B "GO:0003677,GO:0005515,GO:0005654,GO:0046872" DNA binding|protein binding|nucleoplasm|metal ion binding ZNF513 283.6128913 293.3222749 273.9035078 0.933797162 -0.098818891 0.843746971 1 6.063566711 5.906043474 130557 zinc finger protein 513 "GO:0000976,GO:0003677,GO:0005515,GO:0005634,GO:0007601,GO:0010468,GO:0045944,GO:0046872,GO:0050896,GO:0060041" transcription regulatory region sequence-specific DNA binding|DNA binding|protein binding|nucleus|visual perception|regulation of gene expression|positive regulation of transcription by RNA polymerase II|metal ion binding|response to stimulus|retina development in camera-type eye zf-C2H2 ZNF514 377.1778761 358.2794568 396.0762955 1.105495411 0.144693037 0.747056883 1 2.697827915 3.110907644 84874 zinc finger protein 514 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF516 1439.339438 1439.207563 1439.471313 1.00018326 0.000264364 1 1 7.114072404 7.421877677 9658 zinc finger protein 516 "GO:0000978,GO:0000981,GO:0000987,GO:0005634,GO:0006355,GO:0006357,GO:0009409,GO:0033613,GO:0045893,GO:0046872,GO:0050873,GO:0060612,GO:0120162" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|response to cold|activating transcription factor binding|positive regulation of transcription, DNA-templated|metal ion binding|brown fat cell differentiation|adipose tissue development|positive regulation of cold-induced thermogenesis" hsa04714 Thermogenesis ZNF517 102.1745432 114.6900244 89.65906191 0.78175118 -0.355218603 0.604091026 1 0.806644235 0.657758561 340385 zinc finger protein 517 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF518A 328.4545465 327.8307778 329.0783151 1.003805431 0.005479657 0.998097248 1 1.296234864 1.357216619 9849 zinc finger protein 518A "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF518B 364.9066083 361.3243247 368.4888918 1.019828632 0.028326748 0.955909406 1 1.772549629 1.885565113 85460 zinc finger protein 518B "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF519 102.7738174 88.30116925 117.2464656 1.32780196 0.409039986 0.547832753 1 0.661559573 0.916258873 162655 zinc finger protein 519 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF521 7.941498436 4.059823873 11.823173 2.912237912 1.542128219 0.334285655 1 0.021944051 0.066659121 25925 zinc finger protein 521 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0019904,GO:0045944,GO:0046872,GO:0048663" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|protein domain specific binding|positive regulation of transcription by RNA polymerase II|metal ion binding|neuron fate commitment" ZNF524 90.44316643 87.28621328 93.60011957 1.072335665 0.100756572 0.901112223 1 2.957015903 3.307503714 147807 zinc finger protein 524 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding ZNF525 189.3325877 213.1407534 165.524422 0.776596776 -0.364762376 0.50905418 1 1.744477576 1.413113042 170958 zinc finger protein 525 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF526 282.9245424 313.6213942 252.2276906 0.804242616 -0.314297309 0.516358503 1 3.988904377 3.346236542 116115 zinc finger protein 526 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF527 64.72237116 80.1815215 49.26322083 0.614396184 -0.70275884 0.371402673 1 0.743212152 0.476296337 84503 zinc finger protein 527 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF528 217.6825691 197.9164138 237.4487244 1.199742456 0.262724741 0.62054295 1 1.998757359 2.501289921 84436 zinc finger protein 528 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF529 230.6988474 212.1257974 249.2718974 1.175113543 0.232800161 0.655487807 1 1.23786419 1.517290577 57711 zinc finger protein 529 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF530 116.2530363 100.4806409 132.0254318 1.31393899 0.393898289 0.546069636 1 1.004736424 1.377029603 348327 zinc finger protein 530 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF532 1872.748893 1836.055347 1909.442439 1.039969978 0.056541882 0.862853027 1 11.44629814 12.41657413 55205 zinc finger protein 532 "GO:0003677,GO:0005634,GO:0046872" DNA binding|nucleus|metal ion binding ZNF540 15.4942851 15.22433953 15.76423066 1.035462369 0.050275123 1 1 0.221377861 0.239102676 163255 zinc finger protein 540 "GO:0000900,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0017148,GO:0043231,GO:0045892,GO:0046872" "translation repressor activity, mRNA regulatory element binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|negative regulation of translation|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF543 66.35144715 56.83753423 75.86536007 1.334775709 0.416597337 0.599749564 1 0.780113983 1.086131194 125919 zinc finger protein 543 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF544 601.6627783 617.0932288 586.2323278 0.949989889 -0.074015936 0.853510973 1 3.221687977 3.192407989 27300 zinc finger protein 544 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF546 25.46569547 23.34398727 27.58740366 1.181777703 0.240958685 0.849568441 1 0.149241429 0.183967506 339327 zinc finger protein 546 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF547 40.88575168 33.49354696 48.27795641 1.441410683 0.527481444 0.569359735 1 0.615951342 0.926083341 284306 zinc finger protein 547 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF548 172.8260682 162.3929549 183.2591815 1.128492191 0.174396435 0.765231345 1 1.563320715 1.840189593 147694 zinc finger protein 548 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF549 148.7491947 132.9592319 164.5391576 1.237515856 0.30744701 0.610011536 1 1.64643424 2.125255217 256051 zinc finger protein 549 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF550 345.4294498 309.5615704 381.2973292 1.231733412 0.300690042 0.508487895 1 2.606950694 3.34938807 162972 zinc finger protein 550 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF551 144.4936541 145.1387035 143.8486048 0.991111271 -0.012881059 0.996068791 1 1.656323414 1.712314309 90233 zinc finger protein 551 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF552 104.1599178 115.7049804 92.61485516 0.80043966 -0.321135444 0.63826754 1 1.625082938 1.356813197 79818 zinc finger protein 552 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF554 35.48164317 34.50850292 36.45478341 1.056400027 0.079156243 0.965636939 1 0.373607083 0.411679683 115196 zinc finger protein 554 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0005730,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF555 115.2826177 101.4955968 129.0696386 1.271677221 0.346732531 0.597694251 1 0.59351044 0.787265437 148254 zinc finger protein 555 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF557 99.74107368 116.7199364 82.76221099 0.709066622 -0.496006909 0.468288475 1 1.028615454 0.760774622 79230 zinc finger protein 557 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF558 313.7943464 335.9504255 291.6382673 0.868099116 -0.204068322 0.665372411 1 2.146153367 1.943327505 148156 zinc finger protein 558 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF559 149.1203391 158.3331311 139.9075471 0.883627742 -0.178489381 0.772014263 1 1.522790452 1.403542014 84527 zinc finger protein 559 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF561 401.9700685 402.9375194 401.0026175 0.99519801 -0.006944494 0.993757363 1 4.147838187 4.305734376 93134 zinc finger protein 561 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF562 557.910308 589.6894176 526.1311984 0.892217467 -0.164532703 0.681661984 1 2.296300838 2.1370537 54811 zinc finger protein 562 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF563 45.1682622 56.83753423 33.49899016 0.589381482 -0.762726362 0.387404199 1 0.910379696 0.559673803 147837 zinc finger protein 563 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF564 125.5360978 128.899408 122.1727877 0.947814963 -0.077322658 0.914780927 1 2.262842386 2.237143258 163050 zinc finger protein 564 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF565 45.46789932 43.64310664 47.29269199 1.083623409 0.115863465 0.919899646 1 0.707771178 0.799994831 147929 zinc finger protein 565 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF566 102.055777 106.5703767 97.54117724 0.915274772 -0.127723179 0.862733939 1 1.021270316 0.975007892 84924 zinc finger protein 566 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF567 116.342111 106.5703767 126.1138453 1.183385564 0.242920201 0.714834614 1 1.206395534 1.489127616 163081 zinc finger protein 567 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF568 81.44217469 78.15160956 84.73273982 1.084209785 0.116643933 0.888418972 1 0.44856112 0.507283667 374900 zinc finger protein 568 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001701,GO:0005634,GO:0006357,GO:0045892,GO:0046872,GO:0060669" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|in utero embryonic development|nucleus|regulation of transcription by RNA polymerase II|negative regulation of transcription, DNA-templated|metal ion binding|embryonic placenta morphogenesis" hsa05168 Herpes simplex virus 1 infection ZNF569 172.5439985 143.1087915 201.9792054 1.411368255 0.497094466 0.381089013 1 1.527815226 2.249194996 148266 zinc finger protein 569 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF57 88.86134937 80.1815215 97.54117724 1.216504444 0.282741591 0.698080032 1 1.834196568 2.327423987 126295 zinc finger protein 57 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF570 101.0556668 105.5554207 96.55591282 0.914741395 -0.128564155 0.862318719 1 0.953622847 0.909894228 148268 zinc finger protein 570 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF571 35.98912115 35.52345889 36.45478341 1.026217169 0.037336067 1 1 0.455247438 0.487307074 51276 zinc finger protein 571 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF572 155.1061545 163.4079109 146.8043981 0.898392234 -0.154582639 0.800638618 1 2.524720628 2.365893805 137209 zinc finger protein 572 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0042802,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding" ZNF573 28.00308539 28.41876711 27.58740366 0.970745971 -0.042834281 1 1 0.532486237 0.539175207 126231 zinc finger protein 573 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF574 389.3573478 382.6384001 396.0762955 1.035119045 0.049796697 0.91518177 1 5.00368838 5.402521252 64763 zinc finger protein 574 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF575 12.47910874 11.16451565 13.79370183 1.235494872 0.305089022 0.870917903 1 0.283999664 0.365994622 284346 zinc finger protein 575 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF576 169.1549561 147.1686154 191.1412968 1.298791161 0.377169471 0.510902702 1 2.690819925 3.645355509 79177 zinc finger protein 576 "GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0043565,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding" ZNF577 47.0348706 49.73284245 44.33689874 0.891501401 -0.165691029 0.870538997 1 0.243314627 0.226259164 84765 zinc finger protein 577 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF579 311.6483899 290.277407 333.0193728 1.147245238 0.198173818 0.675403022 1 5.036494219 6.026990864 163033 zinc finger protein 579 "GO:0003677,GO:0003723,GO:0005634,GO:0046872" DNA binding|RNA binding|nucleus|metal ion binding ZNF580 308.0218151 278.0979353 337.9456949 1.215203897 0.281198402 0.551296841 1 8.797426205 11.15117717 51157 zinc finger protein 580 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001938,GO:0002690,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006935,GO:0006954,GO:0010595,GO:0010628,GO:0032757,GO:0045944,GO:0046872,GO:0070301,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of endothelial cell proliferation|positive regulation of leukocyte chemotaxis|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|chemotaxis|inflammatory response|positive regulation of endothelial cell migration|positive regulation of gene expression|positive regulation of interleukin-8 production|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to hydrogen peroxide|sequence-specific double-stranded DNA binding" ZNF581 664.6536369 511.5378081 817.7694657 1.598649118 0.676853321 0.076918143 1 17.7085341 29.52920087 51545 zinc finger protein 581 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF584 283.6871202 298.3970547 268.9771857 0.901406973 -0.149749485 0.760992418 1 4.00550176 3.766116669 201514 zinc finger protein 584 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF585A 218.6826793 198.9313698 238.4339888 1.198574106 0.261319112 0.621913599 1 1.154218363 1.443008205 199704 zinc finger protein 585A "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF585B 219.3534608 211.1108414 227.5960802 1.078088073 0.108475042 0.843343854 1 1.725354101 1.940208539 92285 zinc finger protein 585B "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF586 106.6824619 119.7648043 93.60011957 0.781532773 -0.355621722 0.598069062 1 2.700652196 2.201566363 54807 zinc finger protein 586 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF587 705.1667603 721.6336935 688.6998272 0.954362072 -0.067391385 0.861538087 1 5.308380654 5.284344943 84914 zinc finger protein 587 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF587B 129.6107675 138.0340117 121.1875232 0.877954076 -0.187782617 0.771857441 1 2.096232605 1.919672754 100293516 zinc finger protein 587B "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF589 582.6997788 667.8410272 497.5585304 0.745025403 -0.424638477 0.280916299 1 10.04567628 7.806676618 51385 zinc finger protein 589 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0005654,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF592 1929.308317 2065.435396 1793.181238 0.868185585 -0.203924625 0.528342487 1 12.96888376 11.74440713 9640 zinc finger protein 592 "GO:0003677,GO:0005515,GO:0005634,GO:0046872" DNA binding|protein binding|nucleus|metal ion binding ZNF593 238.8900024 266.9334197 210.8465851 0.789884554 -0.340286284 0.505964458 1 21.19002511 17.45866463 51042 zinc finger protein 593 "GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0008270,GO:0045944,GO:1903026" DNA binding|protein binding|nucleoplasm|nucleolus|zinc ion binding|positive regulation of transcription by RNA polymerase II|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding ZNF594 187.020606 189.7967661 184.2444459 0.970745971 -0.042834281 0.948335132 1 1.856060367 1.87937577 84622 zinc finger protein 594 "GO:0000978,GO:0001228,GO:0005634,GO:0005654,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF595 94.39906987 88.30116925 100.4969705 1.138115965 0.186647565 0.799210365 1 1.232674398 1.463358792 152687 zinc finger protein 595 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection other ZNF596 23.98779884 23.34398727 24.63161041 1.055158664 0.077459952 0.986031369 1 0.242869886 0.267305175 169270 zinc finger protein 596 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF598 1086.472008 991.6119811 1181.332035 1.191324891 0.25256691 0.467872327 1 14.91584456 18.53505993 90850 "zinc finger protein 598, E3 ubiquitin ligase" "GO:0003723,GO:0005515,GO:0006513,GO:0016567,GO:0043022,GO:0046872,GO:0061630,GO:0072344" RNA binding|protein binding|protein monoubiquitination|protein ubiquitination|ribosome binding|metal ion binding|ubiquitin protein ligase activity|rescue of stalled ribosome ZNF599 29.84000224 19.2841634 40.39584108 2.094767621 1.06679021 0.284848244 1 0.272585779 0.595600394 148103 zinc finger protein 599 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF600 210.5184942 179.6472064 241.3897821 1.343687925 0.426198108 0.423150661 1 1.928464868 2.702875712 162966 zinc finger protein 600 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF605 362.8739747 390.7580478 334.9899016 0.857282156 -0.222157981 0.621379607 1 2.097564029 1.875663557 100289635 zinc finger protein 605 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF606 37.92995843 33.49354696 42.36636991 1.264911416 0.339036354 0.732207608 1 0.4129333 0.544823646 80095 zinc finger protein 606 "GO:0000978,GO:0001228,GO:0005634,GO:0005654,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF607 136.3740064 128.899408 143.8486048 1.115975683 0.158305591 0.805368168 1 1.307490544 1.521980954 84775 zinc finger protein 607 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF608 36.7638231 54.80762229 18.72002391 0.341558767 -1.54979427 0.099955805 1 0.3522158 0.125484534 57507 zinc finger protein 608 "GO:0000122,GO:0005634,GO:0006357,GO:0046872" negative regulation of transcription by RNA polymerase II|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF609 2537.127141 2429.804588 2644.449694 1.088338423 0.122127238 0.702424931 1 13.54253665 15.37375343 23060 zinc finger protein 609 "GO:0005634,GO:0005654,GO:0006357,GO:0007517,GO:0045944,GO:0046872,GO:1990841,GO:2000291,GO:2001224" nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|muscle organ development|positive regulation of transcription by RNA polymerase II|metal ion binding|promoter-specific chromatin binding|regulation of myoblast proliferation|positive regulation of neuron migration ZNF610 19.82405454 8.119647747 31.52846133 3.882983882 1.957165719 0.088927669 1 0.135318037 0.548071484 162963 zinc finger protein 610 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF611 179.556894 184.7219862 174.3918017 0.944077125 -0.083023371 0.891368151 1 1.989265776 1.958917813 81856 zinc finger protein 611 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF613 88.95042403 86.27125731 91.62959074 1.062110297 0.086933594 0.917901756 1 1.402225557 1.553471991 79898 zinc finger protein 613 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF614 236.9667325 236.4847406 237.4487244 1.004076304 0.00586891 1 1 2.587968419 2.710451373 80110 zinc finger protein 614 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF615 132.9998098 133.9741878 132.0254318 0.985454243 -0.02113921 0.986401182 1 1.48313005 1.52451474 284370 zinc finger protein 615 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF616 152.7766054 172.5425146 133.0106962 0.770886506 -0.37540962 0.527362676 1 2.006122514 1.613109412 90317 zinc finger protein 616 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF618 1168.19749 1257.530445 1078.864536 0.857923194 -0.221079599 0.520447446 1 2.565744702 2.296031171 114991 zinc finger protein 618 "GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005721,GO:0006355,GO:0008134,GO:0035563,GO:0042802,GO:0046872" "DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|pericentric heterochromatin|regulation of transcription, DNA-templated|transcription factor binding|positive regulation of chromatin binding|identical protein binding|metal ion binding" ZNF619 90.8318782 80.1815215 101.4822349 1.265656139 0.339885498 0.635085409 1 1.694871119 2.23752728 285267 zinc finger protein 619 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF620 99.71410373 81.19647747 118.23173 1.456118956 0.542128219 0.427312247 1 0.673377295 1.022754158 253639 zinc finger protein 620 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF621 2166.05929 2017.732465 2314.386114 1.147023282 0.197894675 0.537525938 1 10.74450964 12.85507939 285268 zinc finger protein 621 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF622 727.7657372 751.0674166 704.4640578 0.937950499 -0.09241631 0.80803653 1 22.28407443 21.80170448 90441 zinc finger protein 622 "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005794,GO:0005829,GO:0008270,GO:0008631,GO:0030687,GO:0033674,GO:0042273,GO:0043065,GO:0043410,GO:0046330" "RNA binding|protein binding|nucleoplasm|nucleolus|Golgi apparatus|cytosol|zinc ion binding|intrinsic apoptotic signaling pathway in response to oxidative stress|preribosome, large subunit precursor|positive regulation of kinase activity|ribosomal large subunit biogenesis|positive regulation of apoptotic process|positive regulation of MAPK cascade|positive regulation of JNK cascade" ZNF623 1196.484129 1103.257138 1289.711121 1.169003197 0.225278876 0.510947427 1 12.37839654 15.09371063 9831 zinc finger protein 623 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF624 75.91929997 71.04691779 80.79168216 1.137159565 0.185434706 0.817374293 1 0.620713429 0.736255378 57547 zinc finger protein 624 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF625 50.91654516 45.67301858 56.16007174 1.229611563 0.298202637 0.739556573 1 1.359093576 1.743143849 90589 zinc finger protein 625 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF626 143.0602948 148.1835714 137.9370183 0.9308523 -0.103375823 0.874401704 1 1.101566877 1.069565965 199777 zinc finger protein 626 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF627 189.1720057 168.4826908 209.8613207 1.245595733 0.316835908 0.567555079 1 2.791316295 3.626620337 199692 zinc finger protein 627 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF628 139.5673321 145.1387035 133.9959607 0.923226937 -0.115242777 0.860019691 1 1.294148471 1.246259554 89887 zinc finger protein 628 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007283,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spermatogenesis|metal ion binding" ZNF629 944.2106637 931.729579 956.6917485 1.026791217 0.038142861 0.917642416 1 7.733335993 8.282566939 23361 zinc finger protein 629 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF630 92.50276991 93.37594909 91.62959074 0.981297557 -0.027237426 0.986283302 1 1.331408336 1.362786803 57232 zinc finger protein 630 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF638 1700.184606 1758.918693 1641.450518 0.933215688 -0.099717535 0.76148609 1 13.09466805 12.74654413 27332 zinc finger protein 638 "GO:0003690,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0008380,GO:0016607,GO:0043231" double-stranded DNA binding|RNA binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|RNA splicing|nuclear speck|intracellular membrane-bounded organelle ZNF639 708.2291956 695.2448383 721.2135529 1.037351898 0.052905379 0.891905397 1 9.51410386 10.2946106 51193 zinc finger protein 639 "GO:0000976,GO:0000978,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030307,GO:0043621,GO:0043922,GO:0043923,GO:0045892,GO:0045944,GO:0046718,GO:0046872" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell growth|protein self-association|negative regulation by host of viral transcription|positive regulation by host of viral transcription|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|viral entry into host cell|metal ion binding" zf-C2H2 ZNF641 121.5532244 92.36099312 150.7454557 1.632133335 0.706758921 0.26697892 1 0.429349102 0.730940665 121274 zinc finger protein 641 "GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF644 1118.452524 1123.556257 1113.348791 0.990915038 -0.013166731 0.972476353 1 8.087572591 8.359312108 84146 zinc finger protein 644 "GO:0000978,GO:0000981,GO:0001226,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription corepressor binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF646 837.3973114 769.336624 905.4579988 1.176933439 0.235032732 0.519491666 1 5.008893939 6.149073267 9726 zinc finger protein 646 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF649 67.76723907 86.27125731 49.26322083 0.571027041 -0.808369028 0.295604793 1 1.368839234 0.815314281 65251 zinc finger protein 649 "GO:0000978,GO:0003700,GO:0005515,GO:0005615,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|extracellular space|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF652 330.6301945 375.5337083 285.7266808 0.76085495 -0.394306652 0.391037035 1 1.594120989 1.265141436 22834 zinc finger protein 652 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF653 105.1451822 115.7049804 94.58538399 0.817470291 -0.290761795 0.670671037 1 2.720542746 2.319762171 115950 zinc finger protein 653 "GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005576,GO:0005634,GO:0006357,GO:0008134,GO:0045892,GO:0046872,GO:0050682,GO:1900116,GO:1903507" "DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|extracellular region|nucleus|regulation of transcription by RNA polymerase II|transcription factor binding|negative regulation of transcription, DNA-templated|metal ion binding|AF-2 domain binding|extracellular negative regulation of signal transduction|negative regulation of nucleic acid-templated transcription" ZNF654 363.2572433 450.64045 275.8740366 0.612182144 -0.707967131 0.112832182 1 3.213198511 2.051795838 55279 zinc finger protein 654 "GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF655 520.5499323 527.7771036 513.322761 0.97261279 -0.040062532 0.925955226 1 4.477395043 4.542357587 79027 zinc finger protein 655 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0006357,GO:0046872,GO:2000134" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|nucleolus|cytoplasm|regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of G1/S transition of mitotic cell cycle" ZNF658 55.91709612 50.74779842 61.08639383 1.203725003 0.267505839 0.759653359 1 0.37357514 0.469052202 26149 zinc finger protein 658 "GO:0000976,GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0042254,GO:0045892,GO:0045944,GO:0046872,GO:0071294" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|ribosome biogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to zinc ion" hsa05168 Herpes simplex virus 1 infection ZNF66 54.48373683 53.79266632 55.17480733 1.025693856 0.036600186 0.989865176 1 0.600222247 0.642163729 7617 zinc finger protein 66 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF660 34.8999363 28.41876711 41.38110549 1.456118956 0.542128219 0.578634792 1 0.246710713 0.374714754 285349 zinc finger protein 660 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding ZNF664 2722.630756 2549.569393 2895.69212 1.135757328 0.183654614 0.564526577 1 30.29009979 35.88411017 144348 zinc finger protein 664 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZNF665 52.27567558 37.55337083 66.99798033 1.784073676 0.835175194 0.320875229 1 0.409108572 0.761320097 79788 zinc finger protein 665 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF668 236.9491651 268.9633316 204.9349986 0.761944007 -0.392243113 0.44362584 1 3.592311155 2.855044845 79759 zinc finger protein 668 "GO:0000122,GO:0000978,GO:0001227,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF669 168.9147021 164.4228669 173.4065373 1.054637598 0.076747335 0.903045663 1 4.240039795 4.664328316 79862 zinc finger protein 669 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF670 158.6288088 168.4826908 148.7749269 0.883027961 -0.179468973 0.765533974 1 2.033131741 1.872646943 93474 zinc finger protein 670 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF672 812.5551385 788.6207874 836.4894896 1.060699265 0.085015674 0.819168739 1 13.0953642 14.48857852 79894 zinc finger protein 672 "GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0043565,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding" ZNF674 110.9528483 108.6002886 113.3054079 1.043325108 0.061188783 0.939981387 1 1.282401842 1.395596019 641339 zinc finger protein 674 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF675 208.3698161 167.4677348 249.2718974 1.488477155 0.573837079 0.281350663 1 3.670121149 5.698210696 171392 zinc finger protein 675 "GO:0000122,GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0007249,GO:0008270,GO:0010804,GO:0019221,GO:0031625,GO:0032088,GO:0043508,GO:0045453,GO:0045671,GO:0046329,GO:0048471,GO:2000660,GO:2000678" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|I-kappaB kinase/NF-kappaB signaling|zinc ion binding|negative regulation of tumor necrosis factor-mediated signaling pathway|cytokine-mediated signaling pathway|ubiquitin protein ligase binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of JUN kinase activity|bone resorption|negative regulation of osteoclast differentiation|negative regulation of JNK cascade|perinuclear region of cytoplasm|negative regulation of interleukin-1-mediated signaling pathway|negative regulation of transcription regulatory region DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF676 37.51155511 38.5683268 36.45478341 0.945200024 -0.081308429 0.961125245 1 0.663051491 0.653712681 163223 zinc finger protein 676 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF678 190.0654739 195.8865019 184.2444459 0.940567339 -0.088396859 0.880895216 1 1.148791139 1.127059647 339500 zinc finger protein 678 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF680 136.2255486 118.7498483 153.701249 1.294327961 0.372203218 0.54719479 1 1.095693367 1.479276287 340252 zinc finger protein 680 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF681 130.2842706 116.7199364 143.8486048 1.232425319 0.301500227 0.633384365 1 0.909874252 1.169655364 148213 zinc finger protein 681 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF682 49.97581807 48.71788648 51.23374966 1.051641468 0.072642936 0.957167775 1 0.680471341 0.746437538 91120 zinc finger protein 682 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF684 60.48439798 59.88240213 61.08639383 1.020105935 0.02871898 0.99498713 1 1.502145823 1.598355201 127396 zinc finger protein 684 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF687 1052.10652 999.7316288 1104.481411 1.104777901 0.143756367 0.682185687 1 8.094784998 9.32816515 57592 zinc finger protein 687 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0046872" DNA binding|protein binding|nucleoplasm|cytosol|metal ion binding ZNF688 127.7293133 144.1237475 111.3348791 0.772495033 -0.372402438 0.555798138 1 3.106110372 2.502813617 146542 zinc finger protein 688 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF689 359.7845695 381.6234441 337.9456949 0.885547521 -0.175358367 0.698750848 1 5.433759111 5.019126975 115509 zinc finger protein 689 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0035914,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|skeletal muscle cell differentiation|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF69 140.822542 129.914364 151.7307201 1.167928746 0.223952259 0.718855211 1 1.736527903 2.115504938 7620 zinc finger protein 69 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF691 243.5342548 247.6492563 239.4192532 0.966767503 -0.048759115 0.931556437 1 4.077555649 4.111855748 51058 zinc finger protein 691 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF692 330.0539309 302.4568786 357.6509832 1.182485863 0.241822936 0.601262121 1 5.855647514 7.222487739 55657 zinc finger protein 692 "GO:0000122,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005654,GO:0005730,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF695 149.060956 154.2733072 143.8486048 0.932427051 -0.100937236 0.875511428 1 2.099811547 2.042260387 57116 zinc finger protein 695 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF696 422.0437796 461.8049656 382.2825936 0.827800959 -0.272644174 0.525057617 1 5.021209179 4.3356096 79943 zinc finger protein 696 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF697 406.2471358 493.2686006 319.225671 0.64716398 -0.627796782 0.14623085 1 2.884460741 1.947129782 90874 zinc finger protein 697 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZNF699 136.2997775 123.8246281 148.7749269 1.201497062 0.264833121 0.671765347 1 0.927978779 1.162991894 374879 zinc finger protein 699 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF7 640.6846432 624.1979205 657.1713658 1.052825305 0.07426607 0.850658045 1 6.635898958 7.287389944 7553 zinc finger protein 7 "GO:0000978,GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0007275,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF70 135.4008662 163.4079109 107.3938214 0.65721311 -0.605566835 0.324265029 1 1.165146307 0.798734808 7621 zinc finger protein 70 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF700 196.7099466 178.6322504 214.7876428 1.202401259 0.265918425 0.628254125 1 3.172192604 3.978550732 90592 zinc finger protein 700 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF701 186.2755956 172.5425146 200.0086766 1.159184894 0.2131107 0.705347306 1 1.564667802 1.891867812 55762 zinc finger protein 701 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF703 285.3013504 274.0381115 296.5645894 1.082201989 0.113969798 0.818550202 1 4.185483594 4.724652827 80139 zinc finger protein 703 "GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0008284,GO:0010718,GO:0016363,GO:0017015,GO:0030335,GO:0032991,GO:0033601,GO:0034111,GO:0034333,GO:0045892,GO:0046872,GO:0051726,GO:0060644,GO:0060828,GO:0070491,GO:0071392" "protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|positive regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|nuclear matrix|regulation of transforming growth factor beta receptor signaling pathway|positive regulation of cell migration|protein-containing complex|positive regulation of mammary gland epithelial cell proliferation|negative regulation of homotypic cell-cell adhesion|adherens junction assembly|negative regulation of transcription, DNA-templated|metal ion binding|regulation of cell cycle|mammary gland epithelial cell differentiation|regulation of canonical Wnt signaling pathway|repressing transcription factor binding|cellular response to estradiol stimulus" ZNF704 670.5140051 406.9973433 934.0306669 2.294930624 1.198450541 0.001880453 0.135572682 1.323975826 3.169316025 619279 zinc finger protein 704 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding ZNF706 1699.662282 1756.888781 1642.435782 0.934854727 -0.097185902 0.767421489 1 21.3228418 20.79242497 51123 zinc finger protein 706 "GO:0005634,GO:0005737,GO:0006417,GO:0045892,GO:0046872,GO:1902455" "nucleus|cytoplasm|regulation of translation|negative regulation of transcription, DNA-templated|metal ion binding|negative regulation of stem cell population maintenance" other ZNF707 612.0553136 586.6445497 637.4660775 1.08663087 0.119861938 0.761077421 1 9.405342477 10.66037747 286075 zinc finger protein 707 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF708 99.51838704 101.4955968 97.54117724 0.961038511 -0.057333851 0.948405898 1 1.026846569 1.029348124 7562 zinc finger protein 708 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF709 56.94689787 53.79266632 60.10112941 1.117273664 0.159982602 0.863850374 1 0.55634241 0.648362158 163051 zinc finger protein 709 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF710 490.222741 441.5058462 538.9396359 1.220685163 0.287691151 0.484851896 1 5.974008435 7.606509764 374655 zinc finger protein 710 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF711 163.9911016 130.9293199 197.0528833 1.505032512 0.589794653 0.306214835 1 1.195440448 1.876677978 7552 zinc finger protein 711 "GO:0005515,GO:0005634,GO:0010468,GO:0043565,GO:0045893,GO:0046872" "protein binding|nucleus|regulation of gene expression|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|metal ion binding" zf-C2H2 ZNF713 31.58512283 37.55337083 25.61687483 0.682145817 -0.551847929 0.583937646 1 0.436426285 0.310530348 349075 zinc finger protein 713 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF714 581.5620972 522.7023237 640.4218708 1.225213361 0.293033005 0.457779114 1 3.024797613 3.865662867 148206 zinc finger protein 714 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF716 1.477896625 0 2.95579325 Inf Inf 0.393310999 1 0 0.029971016 441234 zinc finger protein 716 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF717 172.8854513 166.4527788 179.3181238 1.07729126 0.107408354 0.858549116 1 1.65072372 1.854912629 100131827 zinc finger protein 717 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF718 61.43997084 57.8524902 65.02745149 1.12402165 0.168669824 0.850056668 1 0.481991205 0.565105742 255403 zinc finger protein 718 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF720 70.32219637 58.86744617 81.77694657 1.389170958 0.474224155 0.539776857 1 1.080619238 1.565828955 124411 zinc finger protein 720 "GO:0005515,GO:0006355" "protein binding|regulation of transcription, DNA-templated" ZNF721 334.7521231 354.219633 315.2846133 0.890082265 -0.167989413 0.717400972 1 3.839070147 3.564282556 170960 zinc finger protein 721 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF724 108.9080905 103.5255088 114.2906723 1.103985614 0.142721372 0.840631511 1 1.820556182 2.096444788 440519 zinc finger protein 724 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF726 80.93469671 77.1366536 84.73273982 1.098475703 0.13550296 0.867715835 1 0.526580318 0.603352349 730087 zinc finger protein 726 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF727 41.97493653 40.59823873 43.35163433 1.067820568 0.094669242 0.943772922 1 0.191841535 0.213676544 442319 zinc finger protein 727 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF730 54.76852817 39.58328277 69.95377357 1.767255485 0.821510619 0.321694839 1 0.591896555 1.091091268 100129543 zinc finger protein 730 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF736 282.4818908 249.6791682 315.2846133 1.262758986 0.336579308 0.486968856 1 1.352879967 1.781950614 728927 zinc finger protein 736 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF737 125.9248096 121.7947162 130.054903 1.067820568 0.094669242 0.892333818 1 0.705371379 0.785655301 100129842 zinc finger protein 737 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF738 212.1003113 186.7518982 237.4487244 1.27146619 0.346493099 0.515122968 1 1.014297568 1.345197743 148203 zinc finger protein 738 "GO:0000209,GO:0003677,GO:0004842,GO:0005634,GO:0006355" "protein polyubiquitination|DNA binding|ubiquitin-protein transferase activity|nucleus|regulation of transcription, DNA-templated" ZNF74 410.0209306 347.1149412 472.9269199 1.362450485 0.446203799 0.300580761 1 4.787621793 6.803877609 7625 zinc finger protein 74 "GO:0000978,GO:0000981,GO:0003723,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0007275,GO:0015629,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|actin cytoskeleton|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF740 1808.19799 1666.5577 1949.83828 1.169979461 0.226483204 0.486070835 1 9.855823009 12.02782397 283337 zinc finger protein 740 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF746 583.1884516 532.8518834 633.5250198 1.188932684 0.249667034 0.527197956 1 6.245560774 7.74541397 155061 zinc finger protein 746 "GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0031625,GO:0045892,GO:0045944,GO:0046872,GO:1901216" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|ubiquitin protein ligase binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of neuron death" hsa05168 Herpes simplex virus 1 infection ZNF747 303.956548 336.9653815 270.9477146 0.804081753 -0.314585904 0.506143727 1 4.951003142 4.152497105 65988 zinc finger protein 747 "GO:0005515,GO:0006355" "protein binding|regulation of transcription, DNA-templated" ZNF749 209.4859709 210.0958855 208.8760563 0.994193941 -0.008400784 0.997689138 1 2.518488858 2.611722771 388567 zinc finger protein 749 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF75A 118.6095553 126.869496 110.3496147 0.86978839 -0.201263644 0.762858262 1 1.299391791 1.178880149 7627 zinc finger protein 75a "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF75D 441.7720785 362.3392807 521.2048764 1.438444309 0.524509367 0.214091319 1 2.405138442 3.608685728 7626 zinc finger protein 75D "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding" ZNF76 413.2681961 434.4011545 392.1352378 0.902703029 -0.147676647 0.734861554 1 6.039222069 5.686457907 7629 zinc finger protein 76 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006359,GO:0043565,GO:0045944,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of transcription by RNA polymerase III|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF761 18.49461567 18.26920743 18.72002391 1.024676302 0.035168231 1 1 0.202112474 0.216020885 388561 zinc finger protein 761 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF763 9.478778165 8.119647747 10.83790858 1.334775709 0.416597337 0.834100552 1 0.142294642 0.198112907 284390 zinc finger protein 763 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF764 195.8434484 186.7518982 204.9349986 1.09736501 0.134043481 0.812625385 1 3.319875332 3.800045648 92595 zinc finger protein 764 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF765 144.4936541 145.1387035 143.8486048 0.991111271 -0.012881059 0.996068791 1 1.607778502 1.662128369 91661 zinc finger protein 765 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF765-ZNF761 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.028781601 0.029143149 110116772 ZNF765-ZNF761 readthrough "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF766 163.854768 155.2882632 172.4212729 1.110330358 0.150988988 0.80147523 1 1.534895141 1.777652449 90321 zinc finger protein 766 "GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0046872" "DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF768 1042.776199 1001.761541 1083.790858 1.081885074 0.113547253 0.747355996 1 13.67170252 15.42835626 79724 zinc finger protein 768 "GO:0000977,GO:0000981,GO:0003723,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF77 67.88872688 60.8973581 74.88009566 1.229611563 0.298202637 0.710551587 1 1.493576927 1.91562927 58492 zinc finger protein 77 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003674,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF770 982.0906416 1029.165352 935.0159313 0.908518665 -0.138411941 0.697027266 1 9.693805914 9.186373602 54989 zinc finger protein 770 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF771 88.42810027 84.24134538 92.61485516 1.099399051 0.136715139 0.860958559 1 2.049244456 2.349984817 51333 zinc finger protein 771 "GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF772 150.1056035 158.3331311 141.878076 0.896073204 -0.158311499 0.79812142 1 1.414537753 1.322129401 400720 zinc finger protein 772 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF773 95.33979696 85.25630134 105.4232926 1.236545462 0.306315282 0.664890965 1 0.558016399 0.719735593 374928 zinc finger protein 773 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF774 82.78373773 102.5105528 63.05692266 0.61512616 -0.701045764 0.333021449 1 1.279713548 0.821094029 342132 zinc finger protein 774 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF775 144.4194253 140.0639236 148.7749269 1.062193055 0.087046001 0.895831264 1 3.137436363 3.476116417 285971 zinc finger protein 775 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF776 101.0556668 105.5554207 96.55591282 0.914741395 -0.128564155 0.862318719 1 3.020344453 2.881845787 284309 zinc finger protein 776 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF777 397.5039655 434.4011545 360.6067765 0.830123891 -0.268601429 0.538311064 1 6.351295034 5.499473706 27153 zinc finger protein 777 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF778 191.0331709 228.3650929 153.701249 0.67305054 -0.571213254 0.297166798 1 1.504212034 1.056021269 197320 zinc finger protein 778 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF780A 300.5999188 309.5615704 291.6382673 0.942101007 -0.086046348 0.861906069 1 1.981572481 1.947257388 284323 zinc finger protein 780A "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF780B 205.8890877 199.9463258 211.8318496 1.059443572 0.083306749 0.884664346 1 1.072503287 1.185202044 163131 zinc finger protein 780B "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF782 77.05302215 81.19647747 72.90956682 0.897940023 -0.155309011 0.848928481 1 0.54626928 0.511646535 158431 zinc finger protein 782 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF783 395.5037451 432.3712425 358.6362476 0.829463693 -0.269749261 0.537155361 1 4.82124133 4.171307263 100289678 zinc finger family member 783 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II hsa05168 Herpes simplex virus 1 infection ZNF784 74.56016955 79.16656553 69.95377357 0.883627742 -0.178489381 0.826110708 1 2.017869784 1.8598521 147808 zinc finger protein 784 "GO:0000978,GO:0001228,GO:0002244,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|hematopoietic progenitor cell differentiation|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF785 289.2396865 307.5316584 270.9477146 0.881040072 -0.182720456 0.706986242 1 2.583841007 2.374528454 146540 zinc finger protein 785 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF786 196.9892948 231.4099608 162.5686287 0.702513531 -0.509402081 0.348011674 1 3.652258694 2.676283737 136051 zinc finger protein 786 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF787 467.5589379 474.9993932 460.1184825 0.968671727 -0.045920261 0.91720747 1 4.526254669 4.573319464 126208 zinc finger protein 787 "GO:0000981,GO:0005634,GO:0006357,GO:0043565,GO:0046872,GO:1990837" "DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding|sequence-specific double-stranded DNA binding" ZNF789 122.5060757 123.8246281 121.1875232 0.978702905 -0.031057113 0.975185842 1 1.594934026 1.628206672 285989 zinc finger protein 789 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" ZNF79 118.1020774 125.8545401 110.3496147 0.876802812 -0.18967567 0.777337288 1 2.914535193 2.665552051 7633 zinc finger protein 79 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003674,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF790 99.20390414 113.6750685 84.73273982 0.745394227 -0.423924449 0.53782547 1 1.337027681 1.039542749 388536 zinc finger protein 790 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF791 463.7839053 452.6703619 474.8974488 1.049102148 0.069155155 0.872935615 1 4.891435226 5.352664371 163049 zinc finger protein 791 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF792 95.44371739 92.36099312 98.52644165 1.066753814 0.093227268 0.90734039 1 1.149891463 1.279490258 126375 zinc finger protein 792 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF793 4.00044077 4.059823873 3.941057666 0.970745971 -0.042834281 1 1 0.028166542 0.028520364 390927 zinc finger protein 793 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF799 65.47010317 63.94222601 66.99798033 1.047789302 0.067348637 0.952045638 1 0.964397907 1.05401344 90576 zinc finger protein 799 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF8 304.7218474 288.247495 321.1961998 1.114306994 0.156146753 0.744867442 1 1.602493825 1.862589503 7554 zinc finger protein 8 "GO:0000122,GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0008270,GO:0030509" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|BMP signaling pathway" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF800 1340.285475 1133.705817 1546.865134 1.364432564 0.448301092 0.183014188 1 2.259580502 3.215850302 168850 zinc finger protein 800 "GO:0003677,GO:0005634,GO:0046872" DNA binding|nucleus|metal ion binding ZNF804A 117.6863956 97.43577296 137.9370183 1.415671207 0.501486235 0.437680554 1 1.090076909 1.609664882 91752 zinc finger protein 804A "GO:0003674,GO:0005634,GO:0005737,GO:0005886,GO:0010628,GO:0010975,GO:0010976,GO:0030426,GO:0043025,GO:0043197,GO:0043198,GO:0046872,GO:0098793,GO:0098794,GO:1901588,GO:1902952" molecular_function|nucleus|cytoplasm|plasma membrane|positive regulation of gene expression|regulation of neuron projection development|positive regulation of neuron projection development|growth cone|neuronal cell body|dendritic spine|dendritic shaft|metal ion binding|presynapse|postsynapse|dendritic microtubule|positive regulation of dendritic spine maintenance ZNF805 149.7789965 136.0040998 163.5538931 1.202565904 0.26611596 0.659587138 1 0.677365312 0.849665078 390980 zinc finger protein 805 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF808 121.2684331 106.5703767 135.9664895 1.275837561 0.351444658 0.585889479 1 1.281437232 1.705330862 388558 zinc finger protein 808 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF81 319.7504702 338.9952934 300.505647 0.886459644 -0.173873141 0.711850585 1 1.781562282 1.647312175 347344 zinc finger protein 81 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF813 132.9701183 131.9442759 133.9959607 1.015549631 0.022260747 0.984939697 1 1.08605755 1.150455756 126017 zinc finger protein 813 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF814 16.49439529 16.23929549 16.74949508 1.031417594 0.04462856 1 1 0.135876925 0.146182766 730051 zinc finger protein 814 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF816 86.45757143 84.24134538 88.67379749 1.052616113 0.073979384 0.934028359 1 1.567999617 1.721598579 125893 zinc finger protein 816 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF816-ZNF321P 57.99154539 57.8524902 58.13060058 1.004807233 0.006918754 1 1 1.105669637 1.158841569 100529240 ZNF816-ZNF321P readthrough ZNF821 138.9410879 136.0040998 141.878076 1.0431897 0.06100153 0.932296161 1 2.601256744 2.830495307 55565 zinc finger protein 821 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding ZNF823 99.84771571 90.33108119 109.3643502 1.210705649 0.275848154 0.69309585 1 1.738863775 2.195937922 55552 zinc finger protein 823 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF827 840.5230892 881.9967365 799.0494418 0.9059551 -0.142488544 0.697200164 1 2.854679397 2.697614856 152485 zinc finger protein 827 "GO:0003677,GO:0005515,GO:0005634,GO:0010468,GO:0045944,GO:0046872" DNA binding|protein binding|nucleus|regulation of gene expression|positive regulation of transcription by RNA polymerase II|metal ion binding ZNF829 66.91830824 61.91231407 71.92430241 1.161712391 0.21625294 0.794903248 1 0.586868855 0.711140829 374899 zinc finger protein 829 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF83 350.5311996 355.2345889 345.8278102 0.97351953 -0.038718173 0.938153849 1 5.256026508 5.337257365 55769 zinc finger protein 83 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF830 262.1030993 270.9932436 253.2129551 0.934388444 -0.097905664 0.849637207 1 6.132641546 5.977106154 91603 zinc finger protein 830 "GO:0001541,GO:0001546,GO:0001832,GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005694,GO:0006283,GO:0006397,GO:0008270,GO:0008380,GO:0016607,GO:0033260,GO:0033314,GO:0043066,GO:0044773,GO:0048478,GO:0051276,GO:0051301,GO:0060729" ovarian follicle development|preantral ovarian follicle growth|blastocyst growth|nucleic acid binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|chromosome|transcription-coupled nucleotide-excision repair|mRNA processing|zinc ion binding|RNA splicing|nuclear speck|nuclear DNA replication|mitotic DNA replication checkpoint|negative regulation of apoptotic process|mitotic DNA damage checkpoint|replication fork protection|chromosome organization|cell division|intestinal epithelial structure maintenance ZNF836 101.3998412 95.40586103 107.3938214 1.125652242 0.170761192 0.812147112 1 1.13346711 1.330849952 162962 zinc finger protein 836 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF837 16.46470374 14.20938356 18.72002391 1.31744096 0.39773831 0.775274639 1 0.258033399 0.354587168 116412 zinc finger protein 837 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding" ZNF839 460.7120675 411.0571672 510.3669678 1.241596081 0.312195909 0.455488114 1 3.096162313 4.009774807 55778 zinc finger protein 839 GO:0046872 metal ion binding ZNF84 544.0923579 520.6724118 567.5123039 1.089960388 0.124275705 0.759403878 1 3.409648414 3.87646836 7637 zinc finger protein 84 "GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF841 201.94803 199.9463258 203.9497342 1.020022416 0.028600857 0.967659264 1 1.864244483 1.983483135 284371 zinc finger protein 841 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF843 3.030022129 5.074779842 0.985264417 0.194149194 -2.364762376 0.392475142 1 0.133655588 0.027066908 283933 zinc finger protein 843 "GO:0005515,GO:0046872" protein binding|metal ion binding ZNF844 188.3945822 182.6920743 194.0970901 1.062427534 0.087364442 0.882850546 1 1.424370238 1.578476563 284391 zinc finger protein 844 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF845 169.6745583 182.6920743 156.6570422 0.857492274 -0.221804422 0.702952027 1 1.422837008 1.272627484 91664 zinc finger protein 845 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF846 48.8420959 38.5683268 59.11586499 1.532756796 0.616128801 0.4772534 1 0.810182369 1.295304779 162993 zinc finger protein 846 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF85 145.7488641 129.914364 161.5833643 1.243768275 0.314717723 0.603929204 1 1.507032575 1.955140826 7639 zinc finger protein 85 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005634,GO:0005654,GO:0006355,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF850 75.44151354 72.06187375 78.82115332 1.093798277 0.129346694 0.878647292 1 0.473246847 0.539934271 342892 zinc finger protein 850 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF852 75.78568799 61.91231407 89.65906191 1.448162022 0.534223021 0.476683042 1 1.438367107 2.17271532 285346 zinc finger protein 852 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF853 230.2359067 214.1557093 246.3161041 1.150172951 0.201850815 0.700235782 1 2.747968376 3.296786402 54753 zinc finger protein 853 "GO:0000978,GO:0000981,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF860 139.2798191 192.841634 85.71800424 0.444499471 -1.169746394 0.05560451 1 2.014177863 0.93386693 344787 zinc finger protein 860 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF862 111.9408343 75.10674166 148.7749269 1.980846507 0.986117092 0.132333116 1 0.387322218 0.800274842 643641 zinc finger protein 862 "GO:0003674,GO:0005575,GO:0005634,GO:0006355,GO:0008150,GO:0046872,GO:0046983" "molecular_function|cellular_component|nucleus|regulation of transcription, DNA-templated|biological_process|metal ion binding|protein dimerization activity" ZNF865 359.0719722 332.9055576 385.2383869 1.157200227 0.210638511 0.641020786 1 4.480598478 5.408296176 100507290 zinc finger protein 865 "GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF875 376.3262237 367.4140606 385.2383869 1.048512913 0.068344629 0.882630242 1 3.538358245 3.86982668 284459 zinc finger protein 875 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006355,GO:0006357,GO:0007275,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF878 9.478778165 8.119647747 10.83790858 1.334775709 0.416597337 0.834100552 1 0.214854501 0.299135998 729747 zinc finger protein 878 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF879 3.000330577 3.044867905 2.95579325 0.970745971 -0.042834281 1 1 0.045012206 0.045577639 345462 zinc finger protein 879 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF880 26.98812942 26.38885518 27.58740366 1.045418737 0.064080923 0.991192066 1 0.244154626 0.266238689 400713 zinc finger protein 880 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF883 247.8613026 274.0381115 221.6844937 0.808954975 -0.305868687 0.545686877 1 5.833990583 4.922729859 169834 zinc finger protein 883 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF888 212.7859386 199.9463258 225.6255514 1.128430595 0.174317687 0.747654023 1 2.219280305 2.612179046 388559 zinc finger protein 888 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF891 305.7664949 292.3073189 319.225671 1.092089217 0.12709072 0.792314432 1 0.824203012 0.938876018 101060200 zinc finger protein 891 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF90 109.4897974 109.6152446 109.3643502 0.997711136 -0.003305917 1 1 1.48280594 1.543139068 7643 zinc finger protein 90 "GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection ZNF91 340.3371026 331.8906017 348.7836035 1.050899308 0.071624443 0.880947788 1 2.467932482 2.705268089 7644 zinc finger protein 91 "GO:0000978,GO:0001228,GO:0003700,GO:0005634,GO:0006357,GO:0008270,GO:0045892,GO:0045944,GO:0070895" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of transposon integration" hsa05168 Herpes simplex virus 1 infection ZNF92 224.0867878 197.9164138 250.2571618 1.264458854 0.338520092 0.517316911 1 3.049518757 4.022091446 168374 zinc finger protein 92 "GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" zf-C2H2 ZNF93 271.3591908 263.8885518 278.8298299 1.056619653 0.079456149 0.877797912 1 4.837142311 5.331181625 81931 zinc finger protein 93 "GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006357,GO:0008270,GO:0045892,GO:0070895" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|negative regulation of transcription, DNA-templated|negative regulation of transposon integration" hsa05168 Herpes simplex virus 1 infection ZNF99 11.91224765 6.08973581 17.7347595 2.912237912 1.542128219 0.252853725 1 0.039234657 0.11918254 7652 zinc finger protein 99 "GO:0000978,GO:0001228,GO:0003677,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNFX1 2752.174835 3087.496056 2416.853614 0.782787596 -0.3533072 0.267416349 1 21.69105052 17.71089264 57169 zinc finger NFX1-type containing 1 "GO:0003700,GO:0003723,GO:0004386,GO:0008270,GO:0031048,GO:0031380" DNA-binding transcription factor activity|RNA binding|helicase activity|zinc ion binding|heterochromatin assembly by small RNA|nuclear RNA-directed RNA polymerase complex ZNHIT1 1016.782737 1043.374735 990.1907386 0.949026946 -0.075479044 0.832237615 1 54.25384964 53.70627518 10467 zinc finger HIT-type containing 1 "GO:0000812,GO:0005515,GO:0005634,GO:0005654,GO:0031063,GO:0031491,GO:0042826,GO:0043486,GO:0046872" Swr1 complex|protein binding|nucleus|nucleoplasm|regulation of histone deacetylation|nucleosome binding|histone deacetylase binding|histone exchange|metal ion binding ZNHIT2 180.7945366 201.9762377 159.6128355 0.790255514 -0.339608899 0.545578344 1 7.874814404 6.491182079 741 zinc finger HIT-type containing 2 "GO:0005515,GO:0046872" protein binding|metal ion binding ZNHIT3 592.6199709 571.4202102 613.8197315 1.074200248 0.10326296 0.795619028 1 11.07979242 12.41460203 9326 zinc finger HIT-type containing 3 "GO:0000463,GO:0000492,GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0046872,GO:0046966,GO:0048254,GO:0070761" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|box C/D snoRNP assembly|protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|metal ion binding|thyroid hormone receptor binding|snoRNA localization|pre-snoRNP complex" ZNHIT6 562.0888981 605.9287131 518.2490831 0.85529712 -0.225502413 0.571728762 1 4.883537831 4.356798713 54680 zinc finger HIT-type containing 6 "GO:0000463,GO:0000492,GO:0001094,GO:0005515,GO:0005634,GO:0019899,GO:0042802,GO:0046872,GO:0048254,GO:0051117,GO:0051259,GO:0070062,GO:0070761" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|box C/D snoRNP assembly|TFIID-class transcription factor complex binding|protein binding|nucleus|enzyme binding|identical protein binding|metal ion binding|snoRNA localization|ATPase binding|protein complex oligomerization|extracellular exosome|pre-snoRNP complex" ZNRD2 390.8028312 414.1020351 367.5036274 0.887471194 -0.172227803 0.696718053 1 27.27283123 25.24645587 10534 zinc ribbon domain containing 2 "GO:0000278,GO:0005515,GO:0051301" mitotic cell cycle|protein binding|cell division ZNRF1 398.8779417 427.2964627 370.4594206 0.866984525 -0.205921853 0.638033015 1 3.93116411 3.555072399 84937 zinc and ring finger 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005764,GO:0005768,GO:0005829,GO:0016020,GO:0030672,GO:0043161,GO:0046872,GO:0061630,GO:0070936" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|lysosome|endosome|cytosol|membrane|synaptic vesicle membrane|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination ZNRF2 249.7185084 198.9313698 300.505647 1.510599597 0.595121307 0.235826048 1 3.181298419 5.012676802 223082 zinc and ring finger 2 "GO:0000209,GO:0001650,GO:0005654,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0010008,GO:0030659,GO:0032991,GO:0042734,GO:0042995,GO:0043231,GO:0046872,GO:0061630" protein polyubiquitination|fibrillar center|nucleoplasm|cytoplasm|lysosomal membrane|cytosol|plasma membrane|endosome membrane|cytoplasmic vesicle membrane|protein-containing complex|presynaptic membrane|cell projection|intracellular membrane-bounded organelle|metal ion binding|ubiquitin protein ligase activity ZNRF3 249.113791 292.3073189 205.9202631 0.704464958 -0.505400151 0.314564217 1 1.717041812 1.261700268 84133 zinc and ring finger 3 "GO:0004842,GO:0005109,GO:0005515,GO:0005886,GO:0005887,GO:0006511,GO:0016055,GO:0016567,GO:0038018,GO:0046872,GO:0060173,GO:0061630,GO:0072089,GO:0090090,GO:2000051,GO:2000095" "ubiquitin-protein transferase activity|frizzled binding|protein binding|plasma membrane|integral component of plasma membrane|ubiquitin-dependent protein catabolic process|Wnt signaling pathway|protein ubiquitination|Wnt receptor catabolic process|metal ion binding|limb development|ubiquitin protein ligase activity|stem cell proliferation|negative regulation of canonical Wnt signaling pathway|negative regulation of non-canonical Wnt signaling pathway|regulation of Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway ZP1 10.10502236 17.25425146 2.95579325 0.171308112 -2.545334622 0.08803035 1 0.357848881 0.063943076 22917 zona pellucida glycoprotein 1 "GO:0005515,GO:0005576,GO:0005886,GO:0007339,GO:0016021,GO:0035805,GO:0062023" protein binding|extracellular region|plasma membrane|binding of sperm to zona pellucida|integral component of membrane|egg coat|collagen-containing extracellular matrix ZP3 39.57115859 44.65806261 34.48425458 0.772184295 -0.372982883 0.698802028 1 1.432408693 1.153729088 7784 zona pellucida glycoprotein 3 "GO:0001809,GO:0001825,GO:0002455,GO:0002687,GO:0002922,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007339,GO:0016021,GO:0030246,GO:0031012,GO:0032190,GO:0032729,GO:0032753,GO:0035803,GO:0035804,GO:0035805,GO:0042102,GO:0042802,GO:0045892,GO:0045893,GO:0048015,GO:0048018,GO:0048599,GO:0050729,GO:0062023,GO:2000344,GO:2000360,GO:2000368,GO:2000386,GO:2000388" "positive regulation of type IV hypersensitivity|blastocyst formation|humoral immune response mediated by circulating immunoglobulin|positive regulation of leukocyte migration|positive regulation of humoral immune response|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|plasma membrane|binding of sperm to zona pellucida|integral component of membrane|carbohydrate binding|extracellular matrix|acrosin binding|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|egg coat formation|structural constituent of egg coat|egg coat|positive regulation of T cell proliferation|identical protein binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|phosphatidylinositol-mediated signaling|receptor ligand activity|oocyte development|positive regulation of inflammatory response|collagen-containing extracellular matrix|positive regulation of acrosome reaction|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosomal vesicle exocytosis|positive regulation of ovarian follicle development|positive regulation of antral ovarian follicle growth" ZP4 3.507808562 4.059823873 2.95579325 0.728059478 -0.457871781 0.979540436 1 0.106647177 0.080990141 57829 zona pellucida glycoprotein 4 "GO:0002922,GO:0005515,GO:0005576,GO:0005886,GO:0007339,GO:0016021,GO:0032190,GO:0035805,GO:0042102,GO:0042802,GO:0060478,GO:2000344,GO:2000360" positive regulation of humoral immune response|protein binding|extracellular region|plasma membrane|binding of sperm to zona pellucida|integral component of membrane|acrosin binding|egg coat|positive regulation of T cell proliferation|identical protein binding|acrosomal vesicle exocytosis|positive regulation of acrosome reaction|negative regulation of binding of sperm to zona pellucida ZPLD1 2.537389921 5.074779842 0 0 #NAME? 0.174564756 1 0.062917918 0 131368 zona pellucida like domain containing 1 "GO:0005201,GO:0005615,GO:0009986,GO:0016021,GO:0030659" extracellular matrix structural constituent|extracellular space|cell surface|integral component of membrane|cytoplasmic vesicle membrane ZPR1 757.9971728 729.7533413 786.2410044 1.077406515 0.107562695 0.774719077 1 5.652153589 6.351985264 8882 ZPR1 zinc finger "GO:0000226,GO:0001833,GO:0001834,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006397,GO:0007165,GO:0008270,GO:0008283,GO:0008380,GO:0010628,GO:0015030,GO:0021510,GO:0030424,GO:0030426,GO:0030576,GO:0030971,GO:0031369,GO:0031641,GO:0033120,GO:0042023,GO:0042307,GO:0043025,GO:0043204,GO:0045927,GO:0048471,GO:0061564,GO:0071364,GO:0071931,GO:0097504,GO:1902742,GO:1990261,GO:2000672" microtubule cytoskeleton organization|inner cell mass cell proliferation|trophectodermal cell proliferation|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mRNA processing|signal transduction|zinc ion binding|cell population proliferation|RNA splicing|positive regulation of gene expression|Cajal body|spinal cord development|axon|growth cone|Cajal body organization|receptor tyrosine kinase binding|translation initiation factor binding|regulation of myelination|positive regulation of RNA splicing|DNA endoreduplication|positive regulation of protein import into nucleus|neuronal cell body|perikaryon|positive regulation of growth|perinuclear region of cytoplasm|axon development|cellular response to epidermal growth factor stimulus|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|Gemini of coiled bodies|apoptotic process involved in development|pre-mRNA catabolic process|negative regulation of motor neuron apoptotic process ZRANB1 844.7543814 800.800259 888.7085037 1.109775495 0.150267852 0.681081068 1 6.00499083 6.95125802 54764 zinc finger RANBP2-type containing 1 "GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007010,GO:0008234,GO:0016055,GO:0016477,GO:0016579,GO:0018215,GO:0022604,GO:0030177,GO:0035523,GO:0043231,GO:0046872,GO:0070530,GO:0070536,GO:0071947,GO:1990168" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton organization|cysteine-type peptidase activity|Wnt signaling pathway|cell migration|protein deubiquitination|protein phosphopantetheinylation|regulation of cell morphogenesis|positive regulation of Wnt signaling pathway|protein K29-linked deubiquitination|intracellular membrane-bounded organelle|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|protein K33-linked deubiquitination ZRANB2 1639.430262 1714.260631 1564.599893 0.912696626 -0.131792697 0.688890219 1 30.03156465 28.59040677 9406 zinc finger RANBP2-type containing 2 "GO:0001530,GO:0003723,GO:0005515,GO:0005654,GO:0006397,GO:0008380,GO:0046872" lipopolysaccharide binding|RNA binding|protein binding|nucleoplasm|mRNA processing|RNA splicing|metal ion binding ZRANB3 157.7029275 172.5425146 142.8633404 0.82798921 -0.272316127 0.645858267 1 1.081518524 0.934059559 84083 zinc finger RANBP2-type containing 3 "GO:0000733,GO:0003678,GO:0004520,GO:0005515,GO:0005524,GO:0005654,GO:0006281,GO:0006974,GO:0009411,GO:0031297,GO:0032508,GO:0036292,GO:0036310,GO:0043596,GO:0045910,GO:0046872,GO:0048478,GO:0070530,GO:0090305" DNA strand renaturation|DNA helicase activity|endodeoxyribonuclease activity|protein binding|ATP binding|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|response to UV|replication fork processing|DNA duplex unwinding|DNA rewinding|annealing helicase activity|nuclear replication fork|negative regulation of DNA recombination|metal ion binding|replication fork protection|K63-linked polyubiquitin modification-dependent protein binding|nucleic acid phosphodiester bond hydrolysis ZRSR2 175.8560903 167.4677348 184.2444459 1.100178767 0.137737964 0.814770014 1 1.979843599 2.27200913 8233 "zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2" "GO:0000245,GO:0000398,GO:0005515,GO:0005654,GO:0005681,GO:0005689,GO:0008380,GO:0030628,GO:0042802,GO:0046872,GO:0089701" "spliceosomal complex assembly|mRNA splicing, via spliceosome|protein binding|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|RNA splicing|pre-mRNA 3'-splice site binding|identical protein binding|metal ion binding|U2AF complex" ZSCAN12 35.51133472 36.53841486 34.48425458 0.943780805 -0.083476266 0.961664406 1 0.156401438 0.153967058 9753 zinc finger and SCAN domain containing 12 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN16 93.17627304 72.06187375 114.2906723 1.586007501 0.665399594 0.339537456 1 1.212518168 2.005900661 80345 zinc finger and SCAN domain containing 16 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZSCAN2 302.7931343 324.7859099 280.8003587 0.86457063 -0.209944267 0.659895547 1 3.557366038 3.208078321 54993 zinc finger and SCAN domain containing 2 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0007275,GO:0007283,GO:0030154,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|cell differentiation|metal ion binding" zf-C2H2 ZSCAN20 185.2282265 201.9762377 168.4802152 0.834158598 -0.261606387 0.640906414 1 0.771970712 0.671684589 7579 zinc finger and SCAN domain containing 20 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN21 200.4552876 198.9313698 201.9792054 1.015321041 0.021935974 0.977835883 1 3.174282323 3.361745766 7589 zinc finger and SCAN domain containing 21 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN22 139.9857354 140.0639236 139.9075471 0.998883535 -0.001611619 1 1 1.206213844 1.256767939 342945 zinc finger and SCAN domain containing 22 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" zf-C2H2 ZSCAN25 412.461081 446.5806261 378.341536 0.847196483 -0.239231494 0.580152021 1 2.512523136 2.220292253 221785 zinc finger and SCAN domain containing 25 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN26 199.5294063 202.9911937 196.0676189 0.965892241 -0.05006585 0.935712816 1 3.416679245 3.44230079 7741 zinc finger and SCAN domain containing 26 "GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN29 433.9439031 433.3861985 434.5016077 1.002573707 0.003708305 0.999275449 1 3.460425991 3.618776871 146050 zinc finger and SCAN domain containing 29 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZSCAN30 381.1459038 393.8029157 368.4888918 0.935719054 -0.095852664 0.832519063 1 4.460909959 4.353964264 100101467 zinc finger and SCAN domain containing 30 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN31 85.45746124 83.22638941 87.68853307 1.053614529 0.075347145 0.932923609 1 0.892089528 0.980406364 64288 zinc finger and SCAN domain containing 31 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" other ZSCAN32 284.2836728 305.5017465 263.0655992 0.861093602 -0.215758026 0.657660767 1 4.938584652 4.435767702 54925 zinc finger and SCAN domain containing 32 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZSCAN5A 55.58776745 61.91231407 49.26322083 0.795693418 -0.329715429 0.701134966 1 0.937691476 0.778254541 79149 zinc finger and SCAN domain containing 5A "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZSCAN9 160.884129 154.2733072 167.4949508 1.08570273 0.118629141 0.847095284 1 2.645023279 2.995410572 7746 zinc finger and SCAN domain containing 9 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZSWIM1 466.5615493 440.4908903 492.6322083 1.118370934 0.161398771 0.701106462 1 10.53817177 12.2932602 90204 zinc finger SWIM-type containing 1 "GO:0005634,GO:0008270" nucleus|zinc ion binding ZSWIM3 213.4567201 212.1257974 214.7876428 1.012548429 0.017990911 0.98277258 1 3.870109259 4.087473591 140831 zinc finger SWIM-type containing 3 "GO:0005515,GO:0008270" protein binding|zinc ion binding ZSWIM4 651.4267962 516.6125879 786.2410044 1.52191608 0.605888809 0.114703215 1 5.221433861 8.288890768 65249 zinc finger SWIM-type containing 4 "GO:0008270,GO:0031462,GO:1902667" zinc ion binding|Cul2-RING ubiquitin ligase complex|regulation of axon guidance ZSWIM5 163.6387624 241.5595205 85.71800424 0.354852519 -1.494708549 0.01057533 0.437006183 2.060312823 0.762600327 57643 zinc finger SWIM-type containing 5 "GO:0005615,GO:0008270,GO:0031462,GO:1902667" extracellular space|zinc ion binding|Cul2-RING ubiquitin ligase complex|regulation of axon guidance ZSWIM6 700.4037418 732.7982092 668.0092744 0.911586936 -0.133547845 0.726033643 1 5.236862444 4.97949372 57688 zinc finger SWIM-type containing 6 "GO:0008270,GO:0021773,GO:0031462,GO:1902667" zinc ion binding|striatal medium spiny neuron differentiation|Cul2-RING ubiquitin ligase complex|regulation of axon guidance ZSWIM7 307.1350279 352.189721 262.0803348 0.744145326 -0.426343698 0.364545955 1 8.830280653 6.854064627 125150 zinc finger SWIM-type containing 7 "GO:0000724,GO:0005515,GO:0005634,GO:0008270,GO:0050821,GO:0097196" double-strand break repair via homologous recombination|protein binding|nucleus|zinc ion binding|protein stabilization|Shu complex ZSWIM8 3463.508528 3422.431525 3504.58553 1.024004572 0.034222157 0.915196498 1 29.00018122 30.97551511 23053 zinc finger SWIM-type containing 8 "GO:0008270,GO:0031462,GO:1902667" zinc ion binding|Cul2-RING ubiquitin ligase complex|regulation of axon guidance ZSWIM9 223.6535387 201.9762377 245.3308397 1.214651993 0.28054303 0.59310163 1 2.277751928 2.885853098 374920 zinc finger SWIM-type containing 9 GO:0005515 protein binding ZUP1 227.4164471 189.7967661 265.0361281 1.396420674 0.481733621 0.352461206 1 3.714272272 5.410108013 221302 zinc finger containing ubiquitin peptidase 1 "GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0006508,GO:0010468,GO:0018215,GO:0046872" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|proteolysis|regulation of gene expression|protein phosphopantetheinylation|metal ion binding ZW10 936.9817625 976.3876416 897.5758835 0.919282307 -0.121420121 0.73531945 1 17.09318685 16.39033655 9183 zw10 kinetochore protein "GO:0000070,GO:0000132,GO:0000776,GO:0000777,GO:0000922,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005811,GO:0005828,GO:0005829,GO:0006888,GO:0006890,GO:0007030,GO:0007080,GO:0007094,GO:0007096,GO:0015031,GO:0016020,GO:0019237,GO:0034501,GO:0051301,GO:0051321,GO:0065003,GO:0070939,GO:0072413,GO:1990423" "mitotic sister chromatid segregation|establishment of mitotic spindle orientation|kinetochore|condensed chromosome kinetochore|spindle pole|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|kinetochore microtubule|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|mitotic metaphase plate congression|mitotic spindle assembly checkpoint|regulation of exit from mitosis|protein transport|membrane|centromeric DNA binding|protein localization to kinetochore|cell division|meiotic cell cycle|protein-containing complex assembly|Dsl1/NZR complex|signal transduction involved in mitotic cell cycle checkpoint|RZZ complex" ZWILCH 872.7453426 794.7105232 950.780162 1.196385519 0.258682354 0.474571611 1 10.90766516 13.61190392 55055 zwilch kinetochore protein "GO:0000776,GO:0000777,GO:0005515,GO:0005829,GO:0034501,GO:0051301,GO:0072413,GO:1990423" kinetochore|condensed chromosome kinetochore|protein binding|cytosol|protein localization to kinetochore|cell division|signal transduction involved in mitotic cell cycle checkpoint|RZZ complex ZWINT 2749.309846 2521.150625 2977.469067 1.180996104 0.240004206 0.451245006 1 59.55568335 73.36477786 11130 ZW10 interacting kinetochore protein "GO:0000070,GO:0000776,GO:0000777,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007093,GO:0007094,GO:0016604,GO:0030425,GO:0047485,GO:0051301,GO:0051649" mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|protein binding|nucleoplasm|cytoplasm|cytosol|mitotic cell cycle checkpoint|mitotic spindle assembly checkpoint|nuclear body|dendrite|protein N-terminus binding|cell division|establishment of localization in cell ZXDA 120.7312635 103.5255088 137.9370183 1.33239643 0.414023394 0.51972038 1 1.042593319 1.448986462 7789 zinc finger X-linked duplicated A "GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0006357,GO:0045893,GO:0046872,GO:0070742" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription, DNA-templated|metal ion binding|C2H2 zinc finger domain binding" ZXDB 349.7443734 301.4419226 398.0468243 1.320476 0.401058081 0.374765769 1 2.792568128 3.846362564 158586 zinc finger X-linked duplicated B "GO:0003674,GO:0003712,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" molecular_function|transcription coregulator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding ZXDC 516.2201628 534.8817953 497.5585304 0.930221471 -0.104353855 0.80060862 1 4.384184493 4.253937558 79364 ZXD family zinc finger C "GO:0003712,GO:0003713,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0030275,GO:0045893,GO:0046872,GO:0070742" "transcription coregulator activity|transcription coactivator activity|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|LRR domain binding|positive regulation of transcription, DNA-templated|metal ion binding|C2H2 zinc finger domain binding" zf-C2H2 ZYG11B 1123.319463 1119.496433 1127.142493 1.00682991 0.00981998 0.980205796 1 7.130995471 7.488971863 79699 "zyg-11 family member B, cell cycle regulator" "GO:0005515,GO:0006515,GO:0031462,GO:0032436" protein binding|protein quality control for misfolded or incompletely synthesized proteins|Cul2-RING ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process ZYX 4069.862571 4360.25084 3779.474302 0.866802035 -0.206225554 0.517904305 1 99.11639273 89.61513015 7791 zyxin "GO:0001725,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005925,GO:0007160,GO:0007165,GO:0007179,GO:0007229,GO:0007267,GO:0015629,GO:0016032,GO:0043149,GO:0045335,GO:0046872,GO:0050727,GO:0071346" stress fiber|RNA binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|adherens junction|focal adhesion|cell-matrix adhesion|signal transduction|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|cell-cell signaling|actin cytoskeleton|viral process|stress fiber assembly|phagocytic vesicle|metal ion binding|regulation of inflammatory response|cellular response to interferon-gamma hsa04510 Focal adhesion ZZEF1 1886.323868 1955.820151 1816.827584 0.928933871 -0.106352197 0.743508791 1 7.411551884 7.181412636 23140 zinc finger ZZ-type and EF-hand domain containing 1 "GO:0005509,GO:0008270" calcium ion binding|zinc ion binding ZZZ3 1325.964007 1198.662999 1453.265014 1.212405001 0.277871708 0.40995706 1 8.160781322 10.3203729 26009 zinc finger ZZ-type containing 3 "GO:0003677,GO:0005515,GO:0005654,GO:0005671,GO:0005730,GO:0008270,GO:0043967" DNA binding|protein binding|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|nucleolus|zinc ion binding|histone H4 acetylation MYB